locus-tag	class	description
GTW28_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GTW28_00010	COG0592	DNA-directed DNA polymerase activity
GTW28_00015	COG2501	S4 domain
GTW28_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GTW28_00030	COG0187	DNA topoisomerase II activity
GTW28_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GTW28_00070	COG0516	GMP reductase activity
GTW28_00070	COG0517	IMP dehydrogenase activity
GTW28_00075	COG1686	Belongs to the peptidase S11 family
GTW28_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GTW28_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GTW28_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GTW28_00100	COG1428	Deoxynucleoside kinase
GTW28_00105	COG1428	Deoxynucleoside kinase
GTW28_00110	COG3858	chitin binding
GTW28_00110	COG1388	LysM domain
GTW28_00115	COG1335	isochorismatase
GTW28_00120	COG0590	tRNA wobble adenosine to inosine editing
GTW28_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GTW28_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GTW28_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GTW28_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
GTW28_00190	COG3853	Toxic anion resistance protein (TelA)
GTW28_00195	COG1982	Orn Lys Arg decarboxylase major
GTW28_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GTW28_00205	COG3870	Protein conserved in bacteria
GTW28_00210	COG1728	Protein conserved in bacteria
GTW28_00215	COG0470	DNA polymerase III
GTW28_00220	COG1774	PSP1 C-terminal conserved region
GTW28_00225	COG4467	Involved in initiation control of chromosome replication
GTW28_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GTW28_00235	COG2827	Endonuclease containing a URI domain
GTW28_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GTW28_00245	COG2002	toxin-antitoxin pair type II binding
GTW28_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTW28_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTW28_00255	COG0084	hydrolase, TatD family'
GTW28_00260	COG3584	3D domain protein
GTW28_00260	COG3583	domain protein
GTW28_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GTW28_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GTW28_00280	COG4466	Protein conserved in bacteria
GTW28_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GTW28_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GTW28_00300	COG0251	oxidation-reduction process
GTW28_00305	COG2088	sporulation resulting in formation of a cellular spore
GTW28_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GTW28_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GTW28_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GTW28_00325	COG0193	aminoacyl-tRNA hydrolase activity
GTW28_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GTW28_00340	COG2002	toxin-antitoxin pair type II binding
GTW28_00345	COG2244	polysaccharide biosynthetic process
GTW28_00350	COG3956	TIGRFAM MazG family protein
GTW28_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GTW28_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GTW28_00375	COG1098	S1 RNA binding domain
GTW28_00390	COG2208	phosphoserine phosphatase activity
GTW28_00395	COG2304	oxidoreductase activity
GTW28_00400	COG0515	serine threonine protein kinase
GTW28_00405	COG0037	tRNA processing
GTW28_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GTW28_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GTW28_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GTW28_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GTW28_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GTW28_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GTW28_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
GTW28_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GTW28_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GTW28_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GTW28_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GTW28_00470	COG1396	sequence-specific DNA binding
GTW28_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GTW28_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GTW28_00560	COG4463	regulation of RNA biosynthetic process
GTW28_00565	COG3880	PFAM UvrB UvrC protein
GTW28_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GTW28_00575	COG0542	response to heat
GTW28_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GTW28_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GTW28_00590	COG4956	integral membrane protein (PIN domain superfamily)
GTW28_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GTW28_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GTW28_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GTW28_00610	COG1045	serine acetyltransferase
GTW28_00615	COG0215	cysteine-tRNA ligase activity
GTW28_00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GTW28_00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GTW28_00630	COG3688	RNA-binding protein containing a PIN domain
GTW28_00635	COG1595	DNA-templated transcription, initiation
GTW28_00640	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GTW28_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GTW28_00650	COG0250	Participates in transcription elongation, termination and antitermination
GTW28_00655	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GTW28_00660	COG0081	regulation of translation
GTW28_00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GTW28_00670	COG0222	ribosome binding
GTW28_00675	COG2813	Specifically methylates the guanine in position
GTW28_00680	COG0085	RNA polymerase activity
GTW28_00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GTW28_00690	COG1358	cellular component organization or biogenesis
GTW28_00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GTW28_00700	COG0049	tRNA binding
GTW28_00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GTW28_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GTW28_00715	COG0596	Alpha beta hydrolase
GTW28_00720	COG0051	transcription antitermination factor activity, RNA binding
GTW28_00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GTW28_00730	COG0088	Forms part of the polypeptide exit tunnel
GTW28_00735	COG0089	rRNA binding
GTW28_00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GTW28_00745	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GTW28_00750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GTW28_00755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GTW28_00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GTW28_00765	COG0255	Belongs to the universal ribosomal protein uL29 family
GTW28_00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GTW28_00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GTW28_00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GTW28_00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GTW28_00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GTW28_00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GTW28_00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GTW28_00815	COG1841	ribosomal large subunit assembly
GTW28_00820	COG0200	Binds to the 23S rRNA
GTW28_00825	COG0201	protein transport
GTW28_00830	COG0563	adenylate kinase activity
GTW28_00835	COG0024	Methionine aminopeptidase
GTW28_00840	COG2163	COG2163 Ribosomal protein L14E L6E L27E
GTW28_00845	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GTW28_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GTW28_00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GTW28_00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GTW28_00865	COG0202	RNA polymerase activity
GTW28_00870	COG0203	ribosomal protein L17
GTW28_00875	COG1122	ATPase activity
GTW28_00880	COG1122	ATPase activity
GTW28_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GTW28_00890	COG0101	tRNA pseudouridine synthase activity
GTW28_00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GTW28_00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GTW28_00905	COG2226	methyltransferase
GTW28_00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
GTW28_00920	COG0489	protein tyrosine kinase activity
GTW28_00930	COG2194	sulfuric ester hydrolase activity
GTW28_00935	COG0726	polysaccharide deacetylase
GTW28_01020	COG0659	secondary active sulfate transmembrane transporter activity
GTW28_01025	COG0385	Bile acid
GTW28_01030	COG2819	hydrolase of the alpha beta superfamily
GTW28_01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTW28_01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTW28_01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GTW28_01050	COG2207	Transcriptional regulator
GTW28_01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GTW28_01055	COG3876	Protein conserved in bacteria
GTW28_01060	COG1472	Belongs to the glycosyl hydrolase 3 family
GTW28_01065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GTW28_01070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTW28_01070	COG1263	PTS System
GTW28_01075	COG1737	Transcriptional regulator
GTW28_01080	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GTW28_01085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTW28_01090	COG1683	Conserved Protein
GTW28_01120	COG1595	DNA-templated transcription, initiation
GTW28_01125	COG5662	AntiSigma factor
GTW28_01130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GTW28_01135	COG4856	YbbR-like protein
GTW28_01140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GTW28_01150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GTW28_01160	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GTW28_01165	COG2169	Transcriptional regulator
GTW28_01170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GTW28_01175	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GTW28_01180	COG3002	Belongs to the UPF0753 family
GTW28_01185	COG0288	reversible hydration of carbon dioxide
GTW28_01195	COG5609	conserved protein (DUF2294)
GTW28_01200	COG0640	Transcriptional regulator
GTW28_01205	COG2814	Major facilitator Superfamily
GTW28_01220	COG0596	Alpha beta hydrolase
GTW28_01225	COG0745	RESPONSE REGULATOR receiver
GTW28_01230	COG0642	Histidine kinase
GTW28_01240	COG0515	serine threonine protein kinase
GTW28_01255	COG1113	amino acid transport
GTW28_01270	COG2602	Beta-lactamase
GTW28_01275	COG2124	cytochrome p450
GTW28_01285	COG0531	amino acid
GTW28_01290	COG0584	glycerophosphoryl diester phosphodiesterase
GTW28_01295	COG2271	Major facilitator Superfamily
GTW28_01305	COG1846	Transcriptional regulator
GTW28_01305	COG0456	acetyltransferase
GTW28_01310	COG2271	Major facilitator Superfamily
GTW28_01325	COG3409	Peptidoglycan-binding domain 1 protein
GTW28_01330	COG0697	spore germination
GTW28_01335	COG1917	Cupin 2, conserved barrel domain protein
GTW28_01335	COG2207	Transcriptional regulator
GTW28_01340	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GTW28_01345	COG3591	Belongs to the peptidase S1B family
GTW28_01355	COG0596	Alpha beta hydrolase
GTW28_01360	COG1183	phosphatidylcholine synthase activity
GTW28_01365	COG0586	Pfam SNARE associated Golgi protein
GTW28_01370	COG0688	phosphatidylethanolamine metabolic process
GTW28_01380	COG2312	Erythromycin esterase
GTW28_01390	COG1301	dicarboxylic acid transport
GTW28_01395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTW28_01395	COG2190	(PTS) system
GTW28_01395	COG1263	PTS System
GTW28_01400	COG0363	glucosamine-6-phosphate deaminase activity
GTW28_01415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GTW28_01420	COG0833	amino acid
GTW28_01425	COG2040	homocysteine
GTW28_01435	COG1115	amino acid carrier protein
GTW28_01440	COG2066	Belongs to the glutaminase family
GTW28_01445	COG4191	Histidine kinase
GTW28_01450	COG0784	Response regulator, receiver
GTW28_01455	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GTW28_01460	COG1012	belongs to the aldehyde dehydrogenase family
GTW28_01465	COG2271	Major facilitator Superfamily
GTW28_01470	COG4948	Mandelate Racemase Muconate Lactonizing
GTW28_01475	COG2186	Transcriptional regulator
GTW28_01480	COG2721	sulfolactate sulfo-lyase activity
GTW28_01485	COG3173	Aminoglycoside phosphotransferase
GTW28_01495	COG0697	spore germination
GTW28_01500	COG0745	RESPONSE REGULATOR receiver
GTW28_01505	COG2205	protein histidine kinase activity
GTW28_01510	COG1131	(ABC) transporter
GTW28_01530	COG3773	Cell wall hydrolase
GTW28_01535	COG2304	oxidoreductase activity
GTW28_01545	COG3540	Alkaline phosphatase
GTW28_01550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GTW28_01555	COG0805	protein transport
GTW28_01560	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GTW28_01565	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GTW28_01570	COG0477	Major facilitator Superfamily
GTW28_01575	COG1309	transcriptional regulator
GTW28_01580	COG0252	asparaginase activity
GTW28_01585	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GTW28_01590	COG1714	RDD family
GTW28_01595	COG1405	negative regulation of cell septum assembly
GTW28_01595	COG3012	SEC-C Motif Domain Protein
GTW28_01600	COG3290	protein histidine kinase activity
GTW28_01605	COG3279	Response regulator of the LytR AlgR family
GTW28_01610	COG4555	ABC transporter
GTW28_01615	COG1668	transmembrane transport
GTW28_01635	COG1595	DNA-templated transcription, initiation
GTW28_01640	COG1595	DNA-templated transcription, initiation
GTW28_01645	COG1876	peptidase activity
GTW28_01650	COG0457	Tetratricopeptide repeat
GTW28_01655	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_01660	COG0366	Alpha amylase catalytic
GTW28_01665	COG0803	Belongs to the bacterial solute-binding protein 9 family
GTW28_01670	COG1121	(ABC) transporter
GTW28_01675	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GTW28_01680	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GTW28_01685	COG2310	stress, protein
GTW28_01690	COG2310	stress, protein
GTW28_01695	COG2310	stress, protein
GTW28_01700	COG0861	Integral membrane protein TerC family
GTW28_01710	COG3853	Toxic anion resistance protein (TelA)
GTW28_01715	COG0477	Major facilitator Superfamily
GTW28_01720	COG2814	Major facilitator Superfamily
GTW28_01725	COG0640	Transcriptional regulator
GTW28_01730	COG4175	Glycine betaine
GTW28_01730	COG0517	IMP dehydrogenase activity
GTW28_01735	COG4176	ABC-type proline glycine betaine transport system permease component
GTW28_01740	COG2113	Glycine betaine
GTW28_01745	COG1473	amidohydrolase
GTW28_01750	COG1288	antiporter activity
GTW28_01760	COG0366	Alpha amylase catalytic
GTW28_01765	COG0039	L-malate dehydrogenase activity
GTW28_01770	COG1620	l-lactate permease
GTW28_01775	COG2814	Major facilitator Superfamily
GTW28_01780	COG1846	Transcriptional regulator
GTW28_01785	COG1280	lysine exporter protein (LysE YggA)
GTW28_01790	COG3403	YqcI/YcgG family
GTW28_01795	COG1113	amino acid transport
GTW28_01800	COG3665	Urea carboxylase-associated protein
GTW28_01805	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GTW28_01810	COG1660	Displays ATPase and GTPase activities
GTW28_01815	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GTW28_01820	COG2226	methyltransferase
GTW28_01825	COG0583	DNA-binding transcription factor activity
GTW28_01830	COG3458	cephalosporin-C deacetylase activity
GTW28_01835	COG3541	Predicted nucleotidyltransferase
GTW28_01840	COG0506	proline dehydrogenase activity
GTW28_01845	COG1012	belongs to the aldehyde dehydrogenase family
GTW28_01850	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GTW28_01855	COG2508	Transcriptional regulator
GTW28_01860	COG3689	TIGRFAM TIGR03943 family protein
GTW28_01865	COG0701	Predicted permease
GTW28_01870	COG2267	carboxylic ester hydrolase activity
GTW28_01875	COG0492	ferredoxin-NADP+ reductase activity
GTW28_01880	COG1587	Uroporphyrinogen-III synthase
GTW28_01880	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GTW28_01885	COG2146	nitrite reductase [NAD(P)H] activity
GTW28_01890	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GTW28_01895	COG0243	molybdopterin cofactor binding
GTW28_01900	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GTW28_01905	COG2223	nitrite transmembrane transporter activity
GTW28_01910	COG1469	GTP cyclohydrolase I activity
GTW28_01915	COG1376	ErfK ybiS ycfS ynhG family protein
GTW28_01925	COG0523	cobalamin synthesis protein
GTW28_01930	COG0765	amino acid transport
GTW28_01935	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTW28_01945	COG1714	RDD family
GTW28_01955	COG1846	Transcriptional regulator
GTW28_01965	COG3842	ATPase activity
GTW28_01970	COG2723	6-phospho-beta-galactosidase activity
GTW28_01980	COG3209	COG3209 Rhs family protein
GTW28_01985	COG0840	transmembrane signaling receptor activity
GTW28_01985	COG3290	protein histidine kinase activity
GTW28_01990	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GTW28_01995	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GTW28_02000	COG1733	regulation of RNA biosynthetic process
GTW28_02005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GTW28_02010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GTW28_02015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GTW28_02020	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
GTW28_02025	COG2814	Major facilitator Superfamily
GTW28_02035	COG0697	spore germination
GTW28_02040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GTW28_02050	COG2364	Membrane
GTW28_02055	COG1126	abc transporter atp-binding protein
GTW28_02060	COG0765	amino acid transport
GTW28_02065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTW28_02070	COG0583	DNA-binding transcription factor activity
GTW28_02075	COG0163	prenyltransferase activity
GTW28_02080	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GTW28_02095	COG0596	Alpha beta hydrolase
GTW28_02100	COG3104	oligopeptide transport
GTW28_02105	COG5434	Belongs to the glycosyl hydrolase 28 family
GTW28_02115	COG0697	spore germination
GTW28_02125	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GTW28_02130	COG1136	(ABC) transporter
GTW28_02135	COG0577	efflux transmembrane transporter activity
GTW28_02140	COG0745	RESPONSE REGULATOR receiver
GTW28_02145	COG5002	protein histidine kinase activity
GTW28_02145	COG3850	Histidine kinase
GTW28_02150	COG0457	Tetratricopeptide repeat
GTW28_02170	COG0527	aspartate kinase activity
GTW28_02175	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTW28_02180	COG4605	iron ion homeostasis
GTW28_02185	COG4604	ABC transporter, ATP-binding protein
GTW28_02190	COG4607	ABC-type enterochelin transport system periplasmic component
GTW28_02195	COG2814	Major facilitator Superfamily
GTW28_02200	COG1309	transcriptional regulator
GTW28_02205	COG0778	Nitroreductase
GTW28_02210	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GTW28_02215	COG0640	Transcriptional regulator
GTW28_02220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GTW28_02225	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GTW28_02230	COG1012	belongs to the aldehyde dehydrogenase family
GTW28_02235	COG4975	Glucose uptake
GTW28_02240	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_02245	COG4549	nuclear export factor GLE1
GTW28_02250	COG1276	copper resistance
GTW28_02250	COG2372	response to copper ion
GTW28_02255	COG1349	DNA-binding transcription factor activity
GTW28_02265	COG2213	PTS system mannitol-specific
GTW28_02270	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTW28_02275	COG0246	Mannitol dehydrogenase
GTW28_02280	COG0473	3-isopropylmalate dehydrogenase activity
GTW28_02285	COG0681	Belongs to the peptidase S26 family
GTW28_02290	COG0412	Dienelactone hydrolase
GTW28_02295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GTW28_02305	COG0561	phosphatase activity
GTW28_02310	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GTW28_02315	COG1914	H( )-stimulated, divalent metal cation uptake system
GTW28_02320	COG4336	lyase activity
GTW28_02325	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GTW28_02330	COG1984	allophanate hydrolase subunit 2
GTW28_02335	COG1414	Transcriptional regulator
GTW28_02340	COG2755	lipolytic protein G-D-S-L family
GTW28_02350	COG2329	Antibiotic biosynthesis monooxygenase
GTW28_02355	COG0768	penicillin binding
GTW28_02360	COG4989	oxidoreductase activity
GTW28_02365	COG3711	transcriptional antiterminator
GTW28_02370	COG0318	PFAM AMP-dependent synthetase and ligase
GTW28_02375	COG2226	methyltransferase
GTW28_02380	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_02385	COG1917	Cupin 2, conserved barrel domain protein
GTW28_02390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTW28_02395	COG3871	stress protein (general stress protein 26)
GTW28_02405	COG2814	Major facilitator Superfamily
GTW28_02410	COG1522	sequence-specific DNA binding
GTW28_02415	COG0551	DNA topoisomerase type I activity
GTW28_02415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GTW28_02420	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GTW28_02425	COG3706	GGDEF domain
GTW28_02430	COG5298	Protein conserved in bacteria
GTW28_02435	COG1215	transferase activity, transferring glycosyl groups
GTW28_02445	COG0531	amino acid
GTW28_02450	COG0494	nUDIX hydrolase
GTW28_02455	COG0028	Belongs to the TPP enzyme family
GTW28_02470	COG1914	H( )-stimulated, divalent metal cation uptake system
GTW28_02475	COG2261	transglycosylase associated protein
GTW28_02480	COG4876	unkown
GTW28_02485	COG2217	Heavy metal translocating P-type atpase
GTW28_02490	COG3729	General stress protein
GTW28_02495	COG0662	Cupin 2, conserved barrel domain protein
GTW28_02500	COG2329	Antibiotic biosynthesis monooxygenase
GTW28_02505	COG3546	catalase activity
GTW28_02510	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GTW28_02515	COG3290	protein histidine kinase activity
GTW28_02520	COG4565	transcriptional regulatory protein
GTW28_02525	COG1301	dicarboxylic acid transport
GTW28_02530	COG0628	permease
GTW28_02535	COG1131	(ABC) transporter
GTW28_02540	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GTW28_02550	COG1960	acyl-CoA dehydrogenase activity
GTW28_02565	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GTW28_02570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GTW28_02575	COG1181	Belongs to the D-alanine--D-alanine ligase family
GTW28_02580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GTW28_02585	COG0513	Belongs to the DEAD box helicase family
GTW28_02590	COG3402	PFAM membrane-flanked domain
GTW28_02595	COG3428	Bacterial PH domain
GTW28_02600	COG0705	Rhomboid family
GTW28_02605	COG0736	holo-[acyl-carrier-protein] synthase activity
GTW28_02610	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GTW28_02615	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GTW28_02620	COG0864	Transcriptional regulator
GTW28_02625	COG2337	Toxic component of a toxin-antitoxin (TA) module
GTW28_02630	COG1366	Belongs to the anti-sigma-factor antagonist family
GTW28_02635	COG1366	Belongs to the anti-sigma-factor antagonist family
GTW28_02640	COG2172	sigma factor antagonist activity
GTW28_02645	COG2208	phosphoserine phosphatase activity
GTW28_02650	COG1366	Belongs to the anti-sigma-factor antagonist family
GTW28_02655	COG2172	sigma factor antagonist activity
GTW28_02660	COG1191	sigma factor activity
GTW28_02665	COG2208	phosphoserine phosphatase activity
GTW28_02680	COG1673	EVE domain
GTW28_02685	COG1846	Transcriptional regulator
GTW28_02690	COG2183	response to ionizing radiation
GTW28_02700	COG3091	SprT-like family
GTW28_02740	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTW28_02750	COG5444	nuclease activity
GTW28_02755	COG1476	TRANSCRIPTIONal
GTW28_02775	COG0693	protein deglycase activity
GTW28_02780	COG1278	Cold shock
GTW28_02785	COG1329	Transcriptional regulator
GTW28_02790	COG0697	spore germination
GTW28_02795	COG2207	Transcriptional regulator
GTW28_02795	COG1917	Cupin 2, conserved barrel domain protein
GTW28_02800	COG0697	spore germination
GTW28_02805	COG3708	Transcriptional regulator
GTW28_02805	COG2207	Transcriptional regulator
GTW28_02810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GTW28_02815	COG0477	Major facilitator Superfamily
GTW28_02825	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
GTW28_02840	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTW28_02845	COG1309	transcriptional regulator
GTW28_02850	COG0697	spore germination
GTW28_02855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GTW28_02860	COG2030	dehydratase
GTW28_02865	COG3545	Serine hydrolase
GTW28_02870	COG1733	regulation of RNA biosynthetic process
GTW28_02875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GTW28_02880	COG1733	regulation of RNA biosynthetic process
GTW28_02890	COG2814	Major facilitator Superfamily
GTW28_02895	COG1309	transcriptional regulator
GTW28_02900	COG0640	Transcriptional regulator
GTW28_02905	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GTW28_02915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTW28_02920	COG0697	spore germination
GTW28_02925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GTW28_02930	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GTW28_02935	COG0640	Transcriptional regulator
GTW28_02940	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GTW28_02955	COG4585	Histidine kinase
GTW28_02960	COG2197	response regulator
GTW28_02965	COG2409	Drug exporters of the RND superfamily
GTW28_02970	COG0596	Alpha beta hydrolase
GTW28_02975	COG1811	Na channel or pump
GTW28_02980	COG0789	Transcriptional regulator
GTW28_02980	COG4978	Transcriptional regulator
GTW28_02985	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GTW28_02990	COG0778	Nitroreductase
GTW28_02995	COG0346	lactoylglutathione lyase activity
GTW28_03000	COG2259	Doxx family
GTW28_03005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GTW28_03020	COG2323	membrane
GTW28_03025	COG2323	membrane
GTW28_03030	COG0071	Belongs to the small heat shock protein (HSP20) family
GTW28_03045	COG1309	transcriptional regulator
GTW28_03055	COG0456	acetyltransferase
GTW28_03065	COG0673	inositol 2-dehydrogenase activity
GTW28_03070	COG1609	Transcriptional regulator
GTW28_03075	COG2814	Major facilitator Superfamily
GTW28_03090	COG1113	amino acid transport
GTW28_03095	COG2318	DinB family
GTW28_03100	COG1846	Transcriptional regulator
GTW28_03105	COG2409	Drug exporters of the RND superfamily
GTW28_03105	COG1033	growth of symbiont in host cell
GTW28_03110	COG0778	Nitroreductase
GTW28_03115	COG1846	Transcriptional regulator
GTW28_03120	COG2814	Major facilitator Superfamily
GTW28_03125	COG0730	response to heat
GTW28_03130	COG1802	Transcriptional regulator
GTW28_03135	COG3858	chitin binding
GTW28_03135	COG1388	LysM domain
GTW28_03140	COG1819	glycosyl
GTW28_03150	COG1785	Belongs to the alkaline phosphatase family
GTW28_03155	COG5646	InterPro IPR014922
GTW28_03165	COG0454	-acetyltransferase
GTW28_03170	COG1078	dGTPase activity
GTW28_03175	COG1388	LysM domain
GTW28_03180	COG2814	Major facilitator Superfamily
GTW28_03185	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTW28_03190	COG1447	Phosphotransferase system cellobiose-specific component IIA
GTW28_03195	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTW28_03200	COG2723	6-phospho-beta-galactosidase activity
GTW28_03205	COG2188	Transcriptional regulator
GTW28_03210	COG1940	carbohydrate kinase activity
GTW28_03215	COG1482	cell wall glycoprotein biosynthetic process
GTW28_03220	COG4124	Belongs to the glycosyl hydrolase 26 family
GTW28_03265	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GTW28_03270	COG0802	atpase or kinase
GTW28_03275	COG1214	PFAM Peptidase M22, glycoprotease
GTW28_03280	COG0456	acetyltransferase
GTW28_03285	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GTW28_03290	COG0488	(ABC) transporter
GTW28_03295	COG0315	cyclic pyranopterin monophosphate synthase activity
GTW28_03300	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GTW28_03305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GTW28_03310	COG0805	protein transport
GTW28_03320	COG1266	CAAX protease self-immunity
GTW28_03325	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GTW28_03330	COG0459	protein refolding
GTW28_03335	COG4974	Belongs to the 'phage' integrase family
GTW28_03340	COG2856	Zn peptidase
GTW28_03355	COG1396	sequence-specific DNA binding
GTW28_03400	COG5377	YqaJ viral recombinase family
GTW28_03405	COG3723	Recombinational DNA repair protein, rece pathway
GTW28_03410	COG3935	DnaD domain protein
GTW28_03415	COG1484	DNA-dependent DNA replication
GTW28_03480	COG3677	Transposase
GTW28_03495	COG5484	DNA packaging
GTW28_03500	COG1783	phage Terminase large subunit
GTW28_03630	COG3409	Peptidoglycan-binding domain 1 protein
GTW28_03630	COG5632	N-Acetylmuramoyl-L-alanine amidase
GTW28_03630	COG1388	LysM domain
GTW28_03670	COG3378	Phage plasmid primase P4 family
GTW28_03685	COG0270	DNA (cytosine-5-)-methyltransferase activity
GTW28_03690	COG0270	DNA (cytosine-5-)-methyltransferase activity
GTW28_03710	COG1401	restriction endodeoxyribonuclease activity
GTW28_03725	COG1073	alpha beta
GTW28_03730	COG0457	Tetratricopeptide repeat
GTW28_03735	COG1063	alcohol dehydrogenase
GTW28_03740	COG2211	Major facilitator Superfamily
GTW28_03745	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTW28_03750	COG1842	Phage shock protein A
GTW28_03755	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GTW28_03760	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GTW28_03765	COG4260	virion core protein, lumpy skin disease virus
GTW28_03775	COG2814	Major facilitator Superfamily
GTW28_03780	COG1063	alcohol dehydrogenase
GTW28_03785	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GTW28_03790	COG0823	Involved in the tonB-independent uptake of proteins
GTW28_03805	COG2267	carboxylic ester hydrolase activity
GTW28_03815	COG2132	Multicopper oxidase
GTW28_03820	COG1113	amino acid transport
GTW28_03830	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GTW28_03835	COG0714	Associated with various cellular activities
GTW28_03840	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
GTW28_03845	COG1305	Transglutaminase-like
GTW28_03850	COG0519	Catalyzes the synthesis of GMP from XMP
GTW28_03850	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GTW28_03865	COG2252	PERMEase
GTW28_03870	COG3064	Membrane
GTW28_03880	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
GTW28_03890	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GTW28_03895	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GTW28_03900	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GTW28_03905	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GTW28_03910	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GTW28_03915	COG0047	phosphoribosylformylglycinamidine synthase activity
GTW28_03920	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GTW28_03925	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GTW28_03930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GTW28_03935	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GTW28_03940	COG0138	bifunctional purine biosynthesis protein purh
GTW28_03945	COG0151	Belongs to the GarS family
GTW28_03950	COG1522	sequence-specific DNA binding
GTW28_03955	COG0531	amino acid
GTW28_03965	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GTW28_03970	COG1470	cell adhesion involved in biofilm formation
GTW28_03975	COG4496	protein, YerC YecD
GTW28_03980	COG0069	glutamate synthase activity
GTW28_03985	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GTW28_03990	COG0210	DNA helicase
GTW28_03995	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GTW28_04000	COG4851	CamS sex pheromone cAM373 precursor
GTW28_04005	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GTW28_04010	COG1285	pathogenesis
GTW28_04015	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GTW28_04020	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GTW28_04025	COG0154	amidase activity
GTW28_04030	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GTW28_04035	COG1309	transcriptional regulator
GTW28_04040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GTW28_04045	COG1597	lipid kinase activity
GTW28_04050	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GTW28_04080	COG0457	Tetratricopeptide repeat
GTW28_04100	COG5444	nuclease activity
GTW28_04110	COG3586	endonuclease activity
GTW28_04125	COG0457	Tetratricopeptide repeat
GTW28_04135	COG0217	transcriptional regulatory protein
GTW28_04145	COG1309	transcriptional regulator
GTW28_04150	COG3631	Ketosteroid isomerase-related protein
GTW28_04155	COG0702	epimerase
GTW28_04170	COG3546	catalase activity
GTW28_04175	COG0454	-acetyltransferase
GTW28_04185	COG5578	integral membrane protein
GTW28_04190	COG2972	Histidine kinase
GTW28_04195	COG2207	Transcriptional regulator
GTW28_04195	COG4753	response regulator
GTW28_04200	COG1653	transport
GTW28_04205	COG1175	transmembrane transport
GTW28_04210	COG0395	ABC-type sugar transport system, permease component
GTW28_04215	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GTW28_04220	COG2207	Transcriptional regulator
GTW28_04225	COG2755	lipolytic protein G-D-S-L family
GTW28_04235	COG5578	integral membrane protein
GTW28_04240	COG3401	FG-GAP repeat protein
GTW28_04245	COG3401	FG-GAP repeat protein
GTW28_04250	COG2755	lipolytic protein G-D-S-L family
GTW28_04255	COG1874	Beta-galactosidase
GTW28_04265	COG1653	transport
GTW28_04270	COG4209	transmembrane transport
GTW28_04275	COG0395	ABC-type sugar transport system, permease component
GTW28_04280	COG1486	melibiose metabolic process
GTW28_04285	COG2323	membrane
GTW28_04290	COG2329	Antibiotic biosynthesis monooxygenase
GTW28_04295	COG0346	lactoylglutathione lyase activity
GTW28_04310	COG5583	Uncharacterized small protein (DUF2292)
GTW28_04315	COG0670	Belongs to the BI1 family
GTW28_04320	COG0697	spore germination
GTW28_04325	COG1846	Transcriptional regulator
GTW28_04330	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GTW28_04340	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GTW28_04340	COG2124	cytochrome p450
GTW28_04345	COG1368	sulfuric ester hydrolase activity
GTW28_04350	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GTW28_04355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GTW28_04360	COG1442	glycosyl transferase family 8
GTW28_04365	COG1216	Glycosyl transferase, family 2
GTW28_04370	COG1442	glycosyl transferase family 8
GTW28_04375	COG2223	nitrite transmembrane transporter activity
GTW28_04380	COG1011	Hydrolase
GTW28_04385	COG0531	amino acid
GTW28_04390	COG1012	belongs to the aldehyde dehydrogenase family
GTW28_04395	COG0840	transmembrane signaling receptor activity
GTW28_04400	COG0488	(ABC) transporter
GTW28_04410	COG0789	Transcriptional regulator
GTW28_04415	COG2814	Major facilitator Superfamily
GTW28_04425	COG0488	(ABC) transporter
GTW28_04430	COG0513	Belongs to the DEAD box helicase family
GTW28_04435	COG0456	acetyltransferase
GTW28_04440	COG2130	NADP-dependent
GTW28_04445	COG1120	ATPase activity
GTW28_04450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTW28_04455	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTW28_04460	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GTW28_04475	COG3866	Pectate lyase
GTW28_04480	COG0471	metal ion transport
GTW28_04485	COG3290	protein histidine kinase activity
GTW28_04490	COG4565	transcriptional regulatory protein
GTW28_04495	COG3181	Tripartite tricarboxylate transporter family receptor
GTW28_04500	COG2851	Citrate transporter
GTW28_04505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GTW28_04510	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
GTW28_04515	COG1254	Belongs to the acylphosphatase family
GTW28_04520	COG2258	MOSC domain
GTW28_04540	COG0024	Methionine aminopeptidase
GTW28_04545	COG1263	PTS System
GTW28_04545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTW28_04550	COG1368	sulfuric ester hydrolase activity
GTW28_04565	COG1115	amino acid carrier protein
GTW28_04580	COG0697	spore germination
GTW28_04585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTW28_04585	COG1263	PTS System
GTW28_04590	COG0366	Alpha amylase catalytic
GTW28_04595	COG2188	Transcriptional regulator
GTW28_04600	COG0778	Nitroreductase
GTW28_04605	COG0737	Belongs to the 5'-nucleotidase family
GTW28_04610	COG0693	protein deglycase activity
GTW28_04615	COG2814	Major facilitator Superfamily
GTW28_04620	COG4840	Belongs to the UPF0435 family
GTW28_04625	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GTW28_04630	COG4980	gas vesicle protein
GTW28_04635	COG1295	ribonuclease BN
GTW28_04640	COG0477	Major facilitator Superfamily
GTW28_04645	COG0387	Pfam Sodium calcium exchanger
GTW28_04655	COG0668	transmembrane transport
GTW28_04660	COG0535	radical SAM domain protein
GTW28_04670	COG0726	polysaccharide deacetylase
GTW28_04675	COG2084	Dehydrogenase
GTW28_04680	COG0598	Magnesium transport protein CorA
GTW28_04685	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GTW28_04690	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GTW28_04700	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GTW28_04705	COG4637	Psort location Cytoplasmic, score
GTW28_04710	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GTW28_04715	COG0022	dehydrogenase e1 component
GTW28_04720	COG0508	dehydrogenase complex catalyzes the overall conversion of
GTW28_04725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GTW28_04730	COG3284	Transcriptional regulator
GTW28_04740	COG1742	UPF0060 membrane protein
GTW28_04765	COG4842	Belongs to the WXG100 family
GTW28_04770	COG1486	melibiose metabolic process
GTW28_04775	COG1737	Transcriptional regulator
GTW28_04780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTW28_04780	COG1263	PTS System
GTW28_04785	COG1132	(ABC) transporter
GTW28_04790	COG1132	(ABC) transporter
GTW28_04795	COG2259	Doxx family
GTW28_04800	COG2514	catechol 2,3-dioxygenase activity
GTW28_04805	COG1917	Cupin 2, conserved barrel domain protein
GTW28_04805	COG4977	sequence-specific DNA binding
GTW28_04810	COG2814	Major facilitator Superfamily
GTW28_04815	COG1082	Xylose isomerase domain protein TIM barrel
GTW28_04820	COG0673	inositol 2-dehydrogenase activity
GTW28_04825	COG4585	Histidine kinase
GTW28_04830	COG2197	response regulator
GTW28_04835	COG1131	(ABC) transporter
GTW28_04840	COG1511	domain protein
GTW28_04840	COG0842	Transport permease protein
GTW28_04845	COG0842	Transport permease protein
GTW28_04850	COG1695	Transcriptional regulator
GTW28_04855	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GTW28_04860	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
GTW28_04865	COG1309	transcriptional regulator
GTW28_04870	COG2814	Major facilitator Superfamily
GTW28_04880	COG2814	Major facilitator Superfamily
GTW28_04885	COG1846	Transcriptional regulator
GTW28_04890	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GTW28_04890	COG0392	lysyltransferase activity
GTW28_04895	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GTW28_04900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTW28_04905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTW28_04910	COG0384	phenazine biosynthesis protein PhzF
GTW28_04915	COG0778	Nitroreductase
GTW28_04930	COG1090	epimerase
GTW28_04935	COG2137	regulation of response to DNA damage stimulus
GTW28_04945	COG2814	Major facilitator Superfamily
GTW28_04960	COG3103	Sh3 type 3 domain protein
GTW28_04965	COG5658	integral membrane protein
GTW28_04970	COG0596	Alpha beta hydrolase
GTW28_04975	COG0463	Glycosyl transferase, family 2
GTW28_04980	COG4485	Bacterial membrane protein, YfhO
GTW28_04985	COG1988	membrane-bound metal-dependent
GTW28_04990	COG1194	a g-specific adenine glycosylase
GTW28_05000	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_05015	COG3557	Belongs to the UPF0374 family
GTW28_05020	COG1132	(ABC) transporter
GTW28_05025	COG4129	membrane
GTW28_05030	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GTW28_05035	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GTW28_05040	COG0735	belongs to the Fur family
GTW28_05150	COG4326	sporulation control protein
GTW28_05160	COG5577	PFAM Coat F domain
GTW28_05165	COG3340	Belongs to the peptidase S51 family
GTW28_05170	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GTW28_05175	COG0277	FAD linked oxidase domain protein
GTW28_05185	COG0753	catalase activity
GTW28_05190	COG1116	anion transmembrane transporter activity
GTW28_05195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GTW28_05200	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GTW28_05205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GTW28_05215	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GTW28_05225	COG1476	TRANSCRIPTIONal
GTW28_05235	COG3382	B3 4 domain protein
GTW28_05240	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GTW28_05250	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GTW28_05255	COG0789	Transcriptional regulator
GTW28_05260	COG1664	Polymer-forming cytoskeletal
GTW28_05265	COG1664	Polymer-forming cytoskeletal
GTW28_05270	COG2766	serine protein kinase
GTW28_05275	COG2718	Belongs to the UPF0229 family
GTW28_05280	COG1846	Transcriptional regulator
GTW28_05285	COG1566	PFAM secretion protein HlyD family protein
GTW28_05290	COG2814	Major facilitator Superfamily
GTW28_05295	COG0655	NAD(P)H dehydrogenase (quinone) activity
GTW28_05315	COG1725	Transcriptional regulator
GTW28_05320	COG1131	(ABC) transporter
GTW28_05325	COG1131	(ABC) transporter
GTW28_05330	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GTW28_05335	COG1278	Cold shock
GTW28_05340	COG1464	Belongs to the NlpA lipoprotein family
GTW28_05345	COG3706	GGDEF domain
GTW28_05350	COG1823	symporter activity
GTW28_05380	COG5577	PFAM Coat F domain
GTW28_05385	COG1525	nuclease
GTW28_05385	COG4085	toxin activity
GTW28_05385	COG0737	Belongs to the 5'-nucleotidase family
GTW28_05390	COG3764	Sortase (surface protein transpeptidase)
GTW28_05395	COG0564	pseudouridine synthase activity
GTW28_05405	COG0517	IMP dehydrogenase activity
GTW28_05410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GTW28_05415	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GTW28_05415	COG3153	acetyltransferase
GTW28_05420	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GTW28_05425	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GTW28_05430	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GTW28_05435	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GTW28_05440	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GTW28_05445	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GTW28_05450	COG2203	Gaf domain
GTW28_05450	COG4585	Histidine kinase
GTW28_05455	COG2197	response regulator
GTW28_05460	COG0431	NADPH-dependent FMN reductase
GTW28_05475	COG0791	NLP P60 protein
GTW28_05475	COG1388	LysM domain
GTW28_05480	COG1959	2 iron, 2 sulfur cluster binding
GTW28_05485	COG0668	transmembrane transport
GTW28_05490	COG2719	SpoVR family
GTW28_05495	COG1785	Belongs to the alkaline phosphatase family
GTW28_05500	COG1388	LysM domain
GTW28_05500	COG0791	NLP P60 protein
GTW28_05505	COG0583	DNA-binding transcription factor activity
GTW28_05510	COG0372	Belongs to the citrate synthase family
GTW28_05515	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_05520	COG0531	amino acid
GTW28_05525	COG0733	neurotransmitter:sodium symporter activity
GTW28_05530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GTW28_05535	COG0456	acetyltransferase
GTW28_05550	COG1595	DNA-templated transcription, initiation
GTW28_05555	COG0667	Aldo Keto reductase
GTW28_05560	COG0204	Acyl-transferase
GTW28_05565	COG1253	flavin adenine dinucleotide binding
GTW28_05570	COG0789	Transcriptional regulator
GTW28_05575	COG0436	Aminotransferase
GTW28_05580	COG1253	flavin adenine dinucleotide binding
GTW28_05585	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GTW28_05590	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GTW28_05595	COG0584	glycerophosphoryl diester phosphodiesterase
GTW28_05605	COG0668	transmembrane transport
GTW28_05610	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GTW28_05615	COG0726	polysaccharide deacetylase
GTW28_05620	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GTW28_05625	COG1757	Na H antiporter
GTW28_05630	COG0589	response to stress
GTW28_05640	COG1132	(ABC) transporter
GTW28_05645	COG1132	(ABC) transporter
GTW28_05650	COG0702	epimerase
GTW28_05670	COG0189	ligase activity
GTW28_05675	COG0189	ligase activity
GTW28_05680	COG4399	Belongs to the UPF0754 family
GTW28_05685	COG3679	Belongs to the UPF0342 family
GTW28_05690	COG4335	DNA alkylation repair
GTW28_05695	COG0561	phosphatase activity
GTW28_05700	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GTW28_05705	COG0475	glutathione-regulated potassium exporter activity
GTW28_05710	COG0490	domain, Protein
GTW28_05720	COG1024	Enoyl-CoA hydratase
GTW28_05730	COG4152	abc transporter atp-binding protein
GTW28_05735	COG1668	transmembrane transport
GTW28_05740	COG0420	3'-5' exonuclease activity
GTW28_05745	COG4717	serine-type aminopeptidase activity
GTW28_05750	COG3481	metal-dependent phosphohydrolase, HD sub domain
GTW28_05760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GTW28_05790	COG1846	Transcriptional regulator
GTW28_05795	COG4980	gas vesicle protein
GTW28_05810	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GTW28_05815	COG0537	adenosine 5'-monophosphoramidase activity
GTW28_05820	COG1131	(ABC) transporter
GTW28_05825	COG4473	ABC transporter
GTW28_05835	COG1473	amidohydrolase
GTW28_05840	COG3069	C4-dicarboxylate transmembrane transporter activity
GTW28_05850	COG2329	Antibiotic biosynthesis monooxygenase
GTW28_05855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GTW28_05860	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GTW28_05875	COG1309	transcriptional regulator
GTW28_05880	COG1511	domain protein
GTW28_05885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GTW28_05890	COG4377	Putative membrane peptidase family (DUF2324)
GTW28_05900	COG1363	Peptidase, m42
GTW28_05905	COG4405	Protein conserved in bacteria
GTW28_05910	COG1301	dicarboxylic acid transport
GTW28_05920	COG1234	tRNA 3'-trailer cleavage
GTW28_05925	COG0095	Lipoate-protein ligase
GTW28_05930	COG0702	epimerase
GTW28_05935	COG0318	PFAM AMP-dependent synthetase and ligase
GTW28_05945	COG0501	Belongs to the peptidase M48B family
GTW28_05950	COG1404	Belongs to the peptidase S8 family
GTW28_05955	COG0456	acetyltransferase
GTW28_05960	COG0604	alcohol dehydrogenase
GTW28_05965	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GTW28_05970	COG0406	alpha-ribazole phosphatase activity
GTW28_05975	COG0183	Belongs to the thiolase family
GTW28_05980	COG0318	PFAM AMP-dependent synthetase and ligase
GTW28_05985	COG1268	BioY protein
GTW28_05990	COG0840	transmembrane signaling receptor activity
GTW28_05995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GTW28_05995	COG0723	plastoquinol--plastocyanin reductase activity
GTW28_06000	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_06010	COG4903	ComK protein
GTW28_06015	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_06025	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GTW28_06040	COG0398	Pfam SNARE associated Golgi protein
GTW28_06045	COG0681	Belongs to the peptidase S26 family
GTW28_06050	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GTW28_06055	COG1846	Transcriptional regulator
GTW28_06060	COG0738	Major facilitator superfamily
GTW28_06065	COG0673	inositol 2-dehydrogenase activity
GTW28_06070	COG0561	phosphatase activity
GTW28_06075	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GTW28_06080	COG1609	Transcriptional regulator
GTW28_06085	COG3180	Ammonia monooxygenase
GTW28_06090	COG0477	Major facilitator Superfamily
GTW28_06090	COG2814	Major facilitator Superfamily
GTW28_06095	COG4533	DNA binding
GTW28_06105	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
GTW28_06110	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GTW28_06115	COG1074	ATP-dependent DNA helicase activity
GTW28_06120	COG0420	3'-5' exonuclease activity
GTW28_06125	COG0419	ATPase involved in DNA repair
GTW28_06130	COG1403	HNH endonuclease
GTW28_06170	COG5337	Spore coat protein CotH
GTW28_06175	COG0179	Fumarylacetoacetate (FAA) hydrolase
GTW28_06185	COG1404	Belongs to the peptidase S8 family
GTW28_06195	COG0367	asparagine synthase
GTW28_06200	COG2318	DinB family
GTW28_06205	COG1562	ergosterol biosynthetic process
GTW28_06210	COG0534	Mate efflux family protein
GTW28_06215	COG1917	Cupin 2, conserved barrel domain protein
GTW28_06215	COG2207	Transcriptional regulator
GTW28_06220	COG1609	Transcriptional regulator
GTW28_06225	COG0673	inositol 2-dehydrogenase activity
GTW28_06230	COG2318	DinB family
GTW28_06235	COG1279	arginine transmembrane transporter activity
GTW28_06240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GTW28_06245	COG1357	PFAM Pentapeptide repeats (8 copies)
GTW28_06250	COG2267	carboxylic ester hydrolase activity
GTW28_06255	COG0529	Catalyzes the synthesis of activated sulfate
GTW28_06260	COG2046	Belongs to the sulfate adenylyltransferase family
GTW28_06265	COG0175	sulfate reduction
GTW28_06270	COG2045	Belongs to the ComB family
GTW28_06275	COG1809	phosphosulfolactate synthase activity
GTW28_06280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GTW28_06285	COG4948	Mandelate Racemase Muconate Lactonizing
GTW28_06290	COG2814	Major facilitator Superfamily
GTW28_06295	COG0454	-acetyltransferase
GTW28_06300	COG2153	protein acetylation
GTW28_06305	COG0646	methionine synthase
GTW28_06305	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GTW28_06310	COG1666	GTP binding
GTW28_06315	COG2996	Protein conserved in bacteria
GTW28_06335	COG1695	Transcriptional regulator
GTW28_06350	COG3227	Zinc metalloprotease (Elastase)
GTW28_06355	COG1307	EDD domain protein, DegV family
GTW28_06360	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GTW28_06375	COG0561	phosphatase activity
GTW28_06380	COG1073	alpha beta
GTW28_06385	COG2151	metal-sulfur cluster biosynthetic enzyme
GTW28_06395	COG0277	FAD linked oxidase domain protein
GTW28_06400	COG2271	Major facilitator Superfamily
GTW28_06405	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GTW28_06420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GTW28_06425	COG0505	Belongs to the CarA family
GTW28_06430	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GTW28_06435	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GTW28_06450	COG2267	carboxylic ester hydrolase activity
GTW28_06460	COG1744	ABC transporter substrate-binding protein PnrA-like
GTW28_06475	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GTW28_06480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GTW28_06485	COG5504	Zn-dependent protease
GTW28_06490	COG0444	Belongs to the ABC transporter superfamily
GTW28_06495	COG4608	Belongs to the ABC transporter superfamily
GTW28_06505	COG0601	transmembrane transport
GTW28_06510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GTW28_06520	COG0180	Tryptophanyl-tRNA synthetase
GTW28_06525	COG4166	transmembrane transport
GTW28_06530	COG0601	transmembrane transport
GTW28_06535	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GTW28_06540	COG0444	Belongs to the ABC transporter superfamily
GTW28_06545	COG4608	Belongs to the ABC transporter superfamily
GTW28_06550	COG2814	Major facilitator Superfamily
GTW28_06555	COG0456	acetyltransferase
GTW28_06560	COG1393	Belongs to the ArsC family
GTW28_06565	COG0861	Integral membrane protein TerC family
GTW28_06575	COG4862	establishment of competence for transformation
GTW28_06585	COG4469	Competence protein
GTW28_06590	COG1164	Oligoendopeptidase f
GTW28_06605	COG2346	COG2346, Truncated hemoglobins
GTW28_06610	COG0741	lytic transglycosylase activity
GTW28_06615	COG4116	CYTH
GTW28_06625	COG2357	RelA SpoT domain protein
GTW28_06630	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GTW28_06635	COG0564	pseudouridine synthase activity
GTW28_06640	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GTW28_06645	COG0475	glutathione-regulated potassium exporter activity
GTW28_06645	COG0569	domain protein
GTW28_06650	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GTW28_06655	COG0352	thiamine-phosphate diphosphorylase activity
GTW28_06660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GTW28_06665	COG2104	thiamine diphosphate biosynthetic process
GTW28_06670	COG2022	thiamine diphosphate biosynthetic process
GTW28_06675	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GTW28_06680	COG0351	phosphomethylpyrimidine kinase
GTW28_06685	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GTW28_06740	COG0210	DNA helicase
GTW28_06750	COG2153	protein acetylation
GTW28_06755	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GTW28_06760	COG2382	esterase
GTW28_06765	COG0626	cystathionine gamma-synthase activity
GTW28_06770	COG0626	cystathionine gamma-synthase activity
GTW28_06775	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTW28_06780	COG5505	Protein of unknown function (DUF819)
GTW28_06810	COG3677	Transposase
GTW28_06825	COG5484	DNA packaging
GTW28_06830	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GTW28_06835	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_06845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTW28_06845	COG3711	transcriptional antiterminator
GTW28_06850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTW28_06850	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTW28_06850	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTW28_06855	COG1482	cell wall glycoprotein biosynthetic process
GTW28_06865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTW28_06875	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GTW28_06890	COG0109	protoheme IX farnesyltransferase activity
GTW28_06900	COG0726	polysaccharide deacetylase
GTW28_06915	COG5504	Zn-dependent protease
GTW28_06920	COG2205	protein histidine kinase activity
GTW28_06930	COG3383	formate dehydrogenase (NAD+) activity
GTW28_06935	COG2427	Protein of unknown function (DUF1641)
GTW28_06945	COG1051	belongs to the nudix hydrolase family
GTW28_06955	COG2124	cytochrome p450
GTW28_06960	COG1819	glycosyl
GTW28_06970	COG1587	Uroporphyrinogen-III synthase
GTW28_06975	COG0390	transport system, permease component
GTW28_06980	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GTW28_06985	COG0697	spore germination
GTW28_06990	COG4297	protein containing double-stranded beta helix domain
GTW28_07000	COG1252	NADH dehydrogenase
GTW28_07005	COG1904	glucuronate isomerase
GTW28_07010	COG2211	Major facilitator Superfamily
GTW28_07015	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GTW28_07020	COG1063	alcohol dehydrogenase
GTW28_07025	COG1312	Catalyzes the dehydration of D-mannonate
GTW28_07030	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_07035	COG2271	Major facilitator Superfamily
GTW28_07040	COG1609	Transcriptional regulator
GTW28_07045	COG0246	Mannitol dehydrogenase
GTW28_07050	COG2721	sulfolactate sulfo-lyase activity
GTW28_07055	COG0730	response to heat
GTW28_07060	COG2318	DinB family
GTW28_07065	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GTW28_07070	COG0457	Tetratricopeptide repeat
GTW28_07080	COG2350	Protein conserved in bacteria
GTW28_07085	COG1388	LysM domain
GTW28_07085	COG3409	Peptidoglycan-binding domain 1 protein
GTW28_07085	COG5632	N-Acetylmuramoyl-L-alanine amidase
GTW28_07095	COG4195	phage-related replication protein
GTW28_07100	COG3546	catalase activity
GTW28_07105	COG2856	Zn peptidase
GTW28_07110	COG1396	sequence-specific DNA binding
GTW28_07120	COG1522	sequence-specific DNA binding
GTW28_07125	COG1484	DNA-dependent DNA replication
GTW28_07145	COG1595	DNA-templated transcription, initiation
GTW28_07150	COG5484	DNA packaging
GTW28_07150	COG3728	DNA packaging
GTW28_07155	COG1783	phage Terminase large subunit
GTW28_07160	COG5518	Phage portal protein
GTW28_07165	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GTW28_07170	COG4653	Phage capsid family
GTW28_07220	COG5412	phage tail tape measure protein
GTW28_07220	COG3953	SLT domain
GTW28_07225	COG1652	LysM domain
GTW28_07230	COG4193	domain, Protein
GTW28_07240	COG3628	GPW Gp25 family protein
GTW28_07245	COG3299	homolog of phage Mu protein gp47
GTW28_07250	COG3778	Protein conserved in bacteria
GTW28_07290	COG3409	Peptidoglycan-binding domain 1 protein
GTW28_07290	COG5632	N-Acetylmuramoyl-L-alanine amidase
GTW28_07310	COG0306	phosphate transporter
GTW28_07315	COG1392	Phosphate transport regulator
GTW28_07320	COG0531	amino acid
GTW28_07325	COG0346	lactoylglutathione lyase activity
GTW28_07330	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GTW28_07335	COG0463	Glycosyl transferase, family 2
GTW28_07340	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GTW28_07345	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GTW28_07350	COG2362	D-Aminopeptidase
GTW28_07355	COG0601	transmembrane transport
GTW28_07360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GTW28_07365	COG0444	Belongs to the ABC transporter superfamily
GTW28_07370	COG4166	transmembrane transport
GTW28_07375	COG1619	proteins homologs of microcin C7 resistance protein MccF
GTW28_07380	COG4948	Mandelate Racemase Muconate Lactonizing
GTW28_07385	COG0791	NLP P60 protein
GTW28_07390	COG4608	Belongs to the ABC transporter superfamily
GTW28_07395	COG2706	6-phosphogluconolactonase activity
GTW28_07400	COG1834	amidinotransferase
GTW28_07405	COG1607	acyl-coa hydrolase
GTW28_07410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GTW28_07410	COG1017	nitric oxide dioxygenase activity
GTW28_07420	COG2323	membrane
GTW28_07425	COG2318	DinB family
GTW28_07430	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTW28_07435	COG2076	Multidrug Resistance protein
GTW28_07440	COG2076	Multidrug Resistance protein
GTW28_07445	COG0788	formyltetrahydrofolate deformylase activity
GTW28_07450	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GTW28_07455	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GTW28_07460	COG1764	response to oxidative stress
GTW28_07465	COG1846	Transcriptional regulator
GTW28_07470	COG1764	response to oxidative stress
GTW28_07480	COG0590	tRNA wobble adenosine to inosine editing
GTW28_07485	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GTW28_07490	COG1404	Belongs to the peptidase S8 family
GTW28_07495	COG1366	Belongs to the anti-sigma-factor antagonist family
GTW28_07500	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GTW28_07505	COG1122	ATPase activity
GTW28_07510	COG4721	ABC-type cobalt transport system, permease component
GTW28_07520	COG0745	RESPONSE REGULATOR receiver
GTW28_07525	COG5002	protein histidine kinase activity
GTW28_07525	COG3850	Histidine kinase
GTW28_07530	COG3212	peptidase
GTW28_07535	COG3212	peptidase
GTW28_07545	COG2239	Acts as a magnesium transporter
GTW28_07550	COG0789	Transcriptional regulator
GTW28_07565	COG1846	Transcriptional regulator
GTW28_07570	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GTW28_07575	COG0726	polysaccharide deacetylase
GTW28_07580	COG1408	metallophosphoesterase
GTW28_07590	COG0463	Glycosyl transferase, family 2
GTW28_07595	COG3285	dna ligase
GTW28_07595	COG1793	dna ligase
GTW28_07600	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GTW28_07610	COG0586	Pfam SNARE associated Golgi protein
GTW28_07615	COG0861	Integral membrane protein TerC family
GTW28_07620	COG1191	sigma factor activity
GTW28_07640	COG0501	Belongs to the peptidase M48B family
GTW28_07645	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GTW28_07660	COG3594	Acyltransferase
GTW28_07665	COG5002	protein histidine kinase activity
GTW28_07670	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GTW28_07680	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GTW28_07685	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
GTW28_07690	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GTW28_07695	COG0436	Aminotransferase
GTW28_07700	COG1850	ribulose-bisphosphate carboxylase activity
GTW28_07705	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
GTW28_07710	COG0235	Class ii aldolase
GTW28_07715	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GTW28_07720	COG3339	Conserved Protein
GTW28_07735	COG3852	Histidine kinase
GTW28_07740	COG1846	Transcriptional regulator
GTW28_07745	COG1360	Flagellar Motor Protein
GTW28_07750	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GTW28_07755	COG0542	response to heat
GTW28_07760	COG3949	Membrane
GTW28_07765	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GTW28_07770	COG0720	synthase
GTW28_07775	COG0602	queuosine metabolic process
GTW28_07780	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GTW28_07785	COG1733	regulation of RNA biosynthetic process
GTW28_07790	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_07795	COG4641	Protein conserved in bacteria
GTW28_07795	COG1388	LysM domain
GTW28_07800	COG1388	LysM domain
GTW28_07805	COG3858	chitin binding
GTW28_07815	COG4873	Protein conserved in bacteria
GTW28_07825	COG3773	Cell wall hydrolase
GTW28_07830	COG2244	polysaccharide biosynthetic process
GTW28_07835	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GTW28_07840	COG2217	Heavy metal translocating P-type atpase
GTW28_07850	COG0006	proline dipeptidase activity
GTW28_07855	COG1609	Transcriptional regulator
GTW28_07860	COG3711	transcriptional antiterminator
GTW28_07865	COG2190	(PTS) system
GTW28_07865	COG1263	PTS System
GTW28_07865	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTW28_07870	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTW28_07875	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GTW28_07885	COG1533	DNA photolyase activity
GTW28_07890	COG0456	acetyltransferase
GTW28_07895	COG0840	transmembrane signaling receptor activity
GTW28_07900	COG2084	Dehydrogenase
GTW28_07905	COG2340	Cysteine-rich secretory protein family
GTW28_07910	COG0768	penicillin binding
GTW28_07915	COG4191	Histidine kinase
GTW28_07920	COG0436	Aminotransferase
GTW28_07930	COG0835	chemotaxis
GTW28_07930	COG0784	Response regulator, receiver
GTW28_07940	COG2814	Major facilitator Superfamily
GTW28_07945	COG1376	ErfK ybiS ycfS ynhG family protein
GTW28_07950	COG1408	metallophosphoesterase
GTW28_07955	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_07960	COG2200	EAL domain
GTW28_07965	COG4703	Protein of unknown function (DUF1797)
GTW28_07970	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
GTW28_07980	COG0517	IMP dehydrogenase activity
GTW28_07985	COG0583	DNA-binding transcription factor activity
GTW28_07990	COG0716	FMN binding
GTW28_08000	COG0716	FMN binding
GTW28_08005	COG2171	N-acyltransferase activity
GTW28_08010	COG1473	amidohydrolase
GTW28_08020	COG0668	transmembrane transport
GTW28_08025	COG0450	alkyl hydroperoxide reductase
GTW28_08030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GTW28_08045	COG0746	molybdenum cofactor guanylyltransferase activity
GTW28_08050	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GTW28_08055	COG0303	'Molybdopterin
GTW28_08060	COG1763	Mo-molybdopterin cofactor biosynthetic process
GTW28_08065	COG0314	molybdopterin synthase activity
GTW28_08070	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GTW28_08075	COG1132	(ABC) transporter
GTW28_08080	COG1132	(ABC) transporter
GTW28_08090	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTW28_08095	COG1136	(ABC) transporter
GTW28_08100	COG0577	efflux transmembrane transporter activity
GTW28_08105	COG1349	DNA-binding transcription factor activity
GTW28_08110	COG1105	Belongs to the carbohydrate kinase PfkB family
GTW28_08115	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTW28_08115	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTW28_08115	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GTW28_08120	COG0681	Belongs to the peptidase S26 family
GTW28_08130	COG0488	(ABC) transporter
GTW28_08135	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GTW28_08140	COG2309	aminopeptidase activity
GTW28_08150	COG1077	Cell shape determining protein MreB Mrl
GTW28_08155	COG2002	toxin-antitoxin pair type II binding
GTW28_08160	COG3852	Histidine kinase
GTW28_08165	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
GTW28_08165	COG2105	PFAM AIG2 family protein
GTW28_08170	COG0569	domain protein
GTW28_08175	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GTW28_08180	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GTW28_08190	COG0561	phosphatase activity
GTW28_08195	COG0242	peptide deformylase activity
GTW28_08205	COG0497	DNA recombination
GTW28_08210	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GTW28_08215	COG0022	dehydrogenase e1 component
GTW28_08220	COG0508	dehydrogenase complex catalyzes the overall conversion of
GTW28_08225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GTW28_08230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GTW28_08240	COG1982	Orn Lys Arg decarboxylase major
GTW28_08245	COG4476	Belongs to the UPF0223 family
GTW28_08250	COG4493	Belongs to the UPF0637 family
GTW28_08260	COG0483	inositol monophosphate 1-phosphatase activity
GTW28_08270	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GTW28_08290	COG1595	DNA-templated transcription, initiation
GTW28_08320	COG4896	Protein conserved in bacteria
GTW28_08330	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GTW28_08335	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GTW28_08340	COG2066	Belongs to the glutaminase family
GTW28_08345	COG4838	Belongs to the UPF0358 family
GTW28_08350	COG0772	Belongs to the SEDS family
GTW28_08355	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GTW28_08360	COG1612	heme a metabolic process
GTW28_08365	COG0109	protoheme IX farnesyltransferase activity
GTW28_08370	COG2010	Cytochrome c
GTW28_08370	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GTW28_08375	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GTW28_08380	COG1845	cytochrome c oxidase, subunit III
GTW28_08385	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GTW28_08390	COG3336	cytochrome c oxidase
GTW28_08400	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GTW28_08405	COG2340	Cysteine-rich secretory protein family
GTW28_08420	COG3679	Belongs to the UPF0342 family
GTW28_08425	COG4471	UPF0298 protein
GTW28_08430	COG0742	ribosomal rna small subunit methyltransferase
GTW28_08435	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GTW28_08440	COG3314	Sporulation integral membrane protein YlbJ
GTW28_08445	COG1752	Esterase of the alpha-beta hydrolase superfamily
GTW28_08450	COG3480	Lon protease (S16) C-terminal proteolytic domain
GTW28_08455	COG1323	Belongs to the UPF0348 family
GTW28_08465	COG1399	metal-binding, possibly nucleic acid-binding protein
GTW28_08470	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GTW28_08480	COG0454	-acetyltransferase
GTW28_08485	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GTW28_08490	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GTW28_08495	COG2001	Belongs to the MraZ family
GTW28_08500	COG0275	rRNA processing
GTW28_08505	COG4839	cell division protein FtsL
GTW28_08515	COG0768	penicillin binding
GTW28_08520	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GTW28_08525	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GTW28_08530	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GTW28_08535	COG0772	Belongs to the SEDS family
GTW28_08540	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GTW28_08545	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GTW28_08550	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GTW28_08555	COG3879	Bacterial protein of unknown function (DUF881)
GTW28_08560	COG3879	Bacterial protein of unknown function (DUF881)
GTW28_08565	COG3856	small basic protein
GTW28_08570	COG0849	cell division
GTW28_08575	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GTW28_08580	COG1404	Belongs to the peptidase S8 family
GTW28_08580	COG4412	M6 family metalloprotease domain protein
GTW28_08590	COG1191	sigma factor activity
GTW28_08595	COG1191	sigma factor activity
GTW28_08600	COG1119	ATPase activity
GTW28_08605	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GTW28_08610	COG1873	PFAM PRC-barrel domain
GTW28_08620	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GTW28_08625	COG1799	cell septum assembly
GTW28_08630	COG0762	integral membrane protein
GTW28_08635	COG2302	S4 RNA-binding domain
GTW28_08640	COG3599	regulation of cell shape
GTW28_08645	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GTW28_08650	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GTW28_08655	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GTW28_08660	COG0564	pseudouridine synthase activity
GTW28_08665	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GTW28_08670	COG2233	PERMEase
GTW28_08675	COG0540	Belongs to the ATCase OTCase family
GTW28_08680	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GTW28_08685	COG0505	Belongs to the CarA family
GTW28_08690	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GTW28_08695	COG0543	2 iron, 2 sulfur cluster binding
GTW28_08700	COG0167	dihydroorotate dehydrogenase activity
GTW28_08705	COG0284	orotidine-5'-phosphate decarboxylase activity
GTW28_08710	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GTW28_08715	COG0175	sulfate reduction
GTW28_08720	COG0306	phosphate transporter
GTW28_08725	COG2046	Belongs to the sulfate adenylyltransferase family
GTW28_08730	COG0529	Catalyzes the synthesis of activated sulfate
GTW28_08735	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GTW28_08740	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
GTW28_08745	COG1648	precorrin-2 dehydrogenase activity
GTW28_08755	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GTW28_08760	COG1561	YicC-like family, N-terminal region
GTW28_08765	COG2052	Domain of unknown function (DUF370)
GTW28_08770	COG0194	GDP metabolic process
GTW28_08775	COG1758	RNA polymerase activity
GTW28_08780	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GTW28_08785	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GTW28_08790	COG0242	peptide deformylase activity
GTW28_08795	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GTW28_08800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GTW28_08800	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GTW28_08805	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GTW28_08810	COG0631	protein serine/threonine phosphatase activity
GTW28_08815	COG0515	serine threonine protein kinase
GTW28_08815	COG2815	serine threonine protein kinase
GTW28_08820	COG1162	GTPase activity
GTW28_08825	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GTW28_08830	COG1564	THIamine pyrophosphokinase
GTW28_08840	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GTW28_08845	COG1302	Protein conserved in bacteria
GTW28_08850	COG1461	Dihydroxyacetone kinase
GTW28_08855	COG1760	l-serine dehydratase
GTW28_08860	COG1760	l-serine dehydratase
GTW28_08865	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GTW28_08870	COG1349	DNA-binding transcription factor activity
GTW28_08870	COG2050	protein possibly involved in aromatic compounds catabolism
GTW28_08875	COG0416	fatty acid biosynthetic process
GTW28_08880	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GTW28_08885	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_08890	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GTW28_08895	COG0571	ribonuclease III activity
GTW28_08900	COG1196	nuclear chromosome segregation
GTW28_08905	COG0552	protein localization to endoplasmic reticulum
GTW28_08915	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GTW28_08920	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GTW28_08925	COG0228	four-way junction DNA binding
GTW28_08930	COG1837	Belongs to the UPF0109 family
GTW28_08940	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GTW28_08945	COG0336	Belongs to the RNA methyltransferase TrmD family
GTW28_08950	COG0335	large ribosomal subunit rRNA binding
GTW28_08955	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GTW28_08960	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GTW28_08970	COG2257	FlhB HrpN YscU SpaS Family
GTW28_08975	COG0045	succinate-CoA ligase (ADP-forming) activity
GTW28_08980	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GTW28_08985	COG0758	DNA mediated transformation
GTW28_08990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GTW28_08995	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GTW28_09000	COG4974	Belongs to the 'phage' integrase family
GTW28_09005	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GTW28_09010	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GTW28_09015	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GTW28_09020	COG1815	bacterial-type flagellum-dependent cell motility
GTW28_09025	COG1558	bacterial-type flagellum-dependent cell motility
GTW28_09030	COG1677	Flagellar hook-basal body complex protein FliE
GTW28_09035	COG1766	The M ring may be actively involved in energy transduction
GTW28_09040	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GTW28_09045	COG1317	bacterial-type flagellum organization
GTW28_09050	COG1157	protein secretion by the type III secretion system
GTW28_09055	COG2882	bacterial-type flagellum organization
GTW28_09060	COG3334	PFAM MgtE intracellular
GTW28_09065	COG3144	bacterial-type flagellum assembly
GTW28_09070	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GTW28_09075	COG4786	Flagellar basal body rod
GTW28_09080	COG1582	Flagellar protein (FlbD)
GTW28_09085	COG1580	Controls the rotational direction of flagella during chemotaxis
GTW28_09090	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GTW28_09095	COG1776	CheC inhibitor of MCP methylation
GTW28_09095	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GTW28_09100	COG2201	protein-glutamate methylesterase activity
GTW28_09105	COG3190	flagellar
GTW28_09110	COG1338	Plays a role in the flagellum-specific transport system
GTW28_09115	COG1987	bacterial-type flagellum assembly
GTW28_09120	COG1684	flagellar biosynthetic protein fliR
GTW28_09125	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GTW28_09130	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GTW28_09135	COG1419	protein localization to endoplasmic reticulum
GTW28_09140	COG0455	bacterial-type flagellum organization
GTW28_09145	COG2201	protein-glutamate methylesterase activity
GTW28_09150	COG2198	Histidine kinase
GTW28_09150	COG0643	Histidine kinase
GTW28_09155	COG0835	chemotaxis
GTW28_09160	COG1776	CheC inhibitor of MCP methylation
GTW28_09165	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GTW28_09170	COG1191	sigma factor activity
GTW28_09180	COG0052	Belongs to the universal ribosomal protein uS2 family
GTW28_09185	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GTW28_09190	COG0528	UMP kinase activity
GTW28_09195	COG0233	cytoplasmic translational termination
GTW28_09200	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GTW28_09205	COG4589	Belongs to the CDS family
GTW28_09210	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GTW28_09215	COG0750	zinc metalloprotease
GTW28_09220	COG0442	prolyl-tRNA aminoacylation
GTW28_09225	COG2176	DNA-directed DNA polymerase activity
GTW28_09230	COG0779	Required for maturation of 30S ribosomal subunits
GTW28_09235	COG0195	Participates in both transcription termination and antitermination
GTW28_09240	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GTW28_09245	COG1358	cellular component organization or biogenesis
GTW28_09250	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GTW28_09255	COG1550	Protein conserved in bacteria
GTW28_09260	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GTW28_09265	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GTW28_09270	COG0196	riboflavin kinase activity
GTW28_09275	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GTW28_09280	COG1185	polyribonucleotide nucleotidyltransferase activity
GTW28_09285	COG0726	polysaccharide deacetylase
GTW28_09290	COG0612	Peptidase, M16
GTW28_09295	COG1873	PFAM PRC-barrel domain
GTW28_09300	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GTW28_09305	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GTW28_09310	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GTW28_09315	COG0527	aspartate kinase activity
GTW28_09320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GTW28_09325	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GTW28_09330	COG0740	serine-type endopeptidase activity
GTW28_09340	COG1674	ftsk spoiiie
GTW28_09340	COG4980	gas vesicle protein
GTW28_09345	COG2188	Transcriptional regulator
GTW28_09350	COG2814	Major facilitator Superfamily
GTW28_09355	COG0612	Peptidase, M16
GTW28_09360	COG0612	Peptidase, M16
GTW28_09365	COG0300	oxidoreductase activity
GTW28_09380	COG1426	Protein conserved in bacteria
GTW28_09385	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GTW28_09390	COG1546	Belongs to the CinA family
GTW28_09390	COG1058	Belongs to the CinA family
GTW28_09395	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GTW28_09400	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GTW28_09405	COG1418	mRNA catabolic process
GTW28_09410	COG1692	metallophosphoesterase
GTW28_09415	COG2359	stage V sporulation protein S
GTW28_09420	COG1063	alcohol dehydrogenase
GTW28_09425	COG0156	8-amino-7-oxononanoate synthase activity
GTW28_09430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GTW28_09435	COG4550	Control of competence regulator ComK, YlbF/YmcA
GTW28_09445	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GTW28_09450	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GTW28_09465	COG3226	Transcriptional regulator
GTW28_09470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GTW28_09480	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GTW28_09485	COG3321	synthase
GTW28_09490	COG2070	2-Nitropropane dioxygenase
GTW28_09490	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GTW28_09495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GTW28_09500	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GTW28_09505	COG3425	synthase
GTW28_09510	COG1024	Enoyl-CoA hydratase
GTW28_09515	COG1024	Enoyl-CoA hydratase
GTW28_09520	COG0318	PFAM AMP-dependent synthetase and ligase
GTW28_09520	COG0300	oxidoreductase activity
GTW28_09520	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_09520	COG3321	synthase
GTW28_09520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GTW28_09525	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GTW28_09525	COG4221	oxidoreductase activity
GTW28_09525	COG0300	oxidoreductase activity
GTW28_09525	COG3321	synthase
GTW28_09530	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_09530	COG3321	synthase
GTW28_09530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GTW28_09530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GTW28_09530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GTW28_09535	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_09535	COG3321	synthase
GTW28_09535	COG4221	oxidoreductase activity
GTW28_09535	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GTW28_09540	COG3321	synthase
GTW28_09540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GTW28_09540	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GTW28_09540	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GTW28_09545	COG2124	cytochrome p450
GTW28_09555	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GTW28_09560	COG1404	Belongs to the peptidase S8 family
GTW28_09570	COG4195	phage-related replication protein
GTW28_09575	COG1764	response to oxidative stress
GTW28_09580	COG2076	Multidrug Resistance protein
GTW28_09585	COG2076	Multidrug Resistance protein
GTW28_09600	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GTW28_09605	COG1923	regulation of RNA biosynthetic process
GTW28_09620	COG1780	Probably involved in ribonucleotide reductase function
GTW28_09625	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GTW28_09630	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GTW28_09635	COG4112	unkown
GTW28_09640	COG0860	N-Acetylmuramoyl-L-alanine amidase
GTW28_09645	COG0464	growth
GTW28_09650	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GTW28_09655	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GTW28_09660	COG0789	Transcriptional regulator
GTW28_09665	COG0174	glutamine synthetase
GTW28_09685	COG4282	regulation of fungal-type cell wall biogenesis
GTW28_09700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTW28_09715	COG3655	Transcriptional regulator
GTW28_09740	COG0135	phosphoribosylanthranilate isomerase activity
GTW28_09745	COG2211	Major facilitator Superfamily
GTW28_09750	COG3507	Belongs to the glycosyl hydrolase 43 family
GTW28_09755	COG1940	carbohydrate kinase activity
GTW28_09760	COG2115	Belongs to the xylose isomerase family
GTW28_09765	COG1070	Carbohydrate kinase
GTW28_09775	COG1525	nuclease
GTW28_09780	COG2814	Major facilitator Superfamily
GTW28_09785	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GTW28_09800	COG0756	dUTP diphosphatase activity
GTW28_09840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GTW28_09850	COG3832	glyoxalase III activity
GTW28_09890	COG4195	phage-related replication protein
GTW28_09900	COG0346	lactoylglutathione lyase activity
GTW28_09905	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GTW28_09910	COG1388	LysM domain
GTW28_09915	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GTW28_09920	COG4224	UPF0291 protein
GTW28_09925	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GTW28_09935	COG3763	UPF0154 protein
GTW28_09945	COG0785	Cytochrome C biogenesis protein
GTW28_09950	COG2201	protein-glutamate methylesterase activity
GTW28_09955	COG4846	Membrane protein involved in cytochrome C biogenesis
GTW28_09965	COG0071	Belongs to the small heat shock protein (HSP20) family
GTW28_09980	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GTW28_09985	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GTW28_10005	COG0824	Thioesterase
GTW28_10015	COG4841	protein insertion into membrane
GTW28_10020	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GTW28_10025	COG1832	CoA-binding protein
GTW28_10030	COG0187	DNA topoisomerase II activity
GTW28_10035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GTW28_10045	COG1115	amino acid carrier protein
GTW28_10050	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GTW28_10060	COG5520	Belongs to the glycosyl hydrolase 30 family
GTW28_10065	COG3507	Belongs to the glycosyl hydrolase 43 family
GTW28_10070	COG2246	polysaccharide biosynthetic process
GTW28_10075	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GTW28_10080	COG0586	Pfam SNARE associated Golgi protein
GTW28_10085	COG2404	hydrolase activity, acting on ester bonds
GTW28_10090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GTW28_10095	COG1024	Enoyl-CoA hydratase
GTW28_10100	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GTW28_10105	COG0511	ligase activity, forming carbon-carbon bonds
GTW28_10110	COG0439	Biotin carboxylase
GTW28_10115	COG0318	PFAM AMP-dependent synthetase and ligase
GTW28_10120	COG1960	acyl-CoA dehydrogenase activity
GTW28_10135	COG1649	PFAM Uncharacterised BCR, COG1649
GTW28_10145	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GTW28_10145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GTW28_10150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GTW28_10155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GTW28_10160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GTW28_10165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GTW28_10170	COG2027	D-alanyl-D-alanine carboxypeptidase
GTW28_10175	COG2017	converts alpha-aldose to the beta-anomer
GTW28_10180	COG0534	Mate efflux family protein
GTW28_10195	COG0582	viral genome integration into host DNA
GTW28_10200	COG0166	Belongs to the GPI family
GTW28_10205	COG0405	Gamma-glutamyltransferase
GTW28_10210	COG0583	DNA-binding transcription factor activity
GTW28_10215	COG0604	alcohol dehydrogenase
GTW28_10220	COG0493	'glutamate synthase
GTW28_10225	COG0069	glutamate synthase activity
GTW28_10225	COG0070	glutamate synthase
GTW28_10225	COG0067	glutamate synthase
GTW28_10230	COG0583	DNA-binding transcription factor activity
GTW28_10235	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GTW28_10240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GTW28_10250	COG0300	oxidoreductase activity
GTW28_10255	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GTW28_10265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GTW28_10280	COG1131	(ABC) transporter
GTW28_10290	COG2814	Major facilitator Superfamily
GTW28_10295	COG1070	Carbohydrate kinase
GTW28_10300	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GTW28_10305	COG0243	molybdopterin cofactor binding
GTW28_10315	COG2814	Major facilitator Superfamily
GTW28_10320	COG0673	inositol 2-dehydrogenase activity
GTW28_10325	COG1082	Xylose isomerase domain protein TIM barrel
GTW28_10330	COG1609	Transcriptional regulator
GTW28_10350	COG0840	transmembrane signaling receptor activity
GTW28_10350	COG5278	phosphoserine phosphatase activity
GTW28_10355	COG2368	4-hydroxyphenylacetate
GTW28_10360	COG4305	rare lipoprotein A
GTW28_10365	COG3619	membrane
GTW28_10370	COG3866	Pectate lyase
GTW28_10375	COG2135	peptidase activity
GTW28_10385	COG2140	Oxalate decarboxylase
GTW28_10395	COG0456	acetyltransferase
GTW28_10415	COG2720	vancomycin resistance protein
GTW28_10430	COG3739	integral membrane protein
GTW28_10435	COG0583	DNA-binding transcription factor activity
GTW28_10440	COG0697	spore germination
GTW28_10450	COG0693	protein deglycase activity
GTW28_10455	COG2367	Beta-lactamase
GTW28_10475	COG3848	Pyruvate phosphate dikinase
GTW28_10475	COG0574	Belongs to the PEP-utilizing enzyme family
GTW28_10480	COG0726	polysaccharide deacetylase
GTW28_10510	COG2205	protein histidine kinase activity
GTW28_10525	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
GTW28_10545	COG5444	nuclease activity
GTW28_10550	COG4282	regulation of fungal-type cell wall biogenesis
GTW28_10555	COG1231	oxidoreductase activity
GTW28_10560	COG5434	Belongs to the glycosyl hydrolase 28 family
GTW28_10565	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTW28_10570	COG2207	Transcriptional regulator
GTW28_10570	COG0662	Cupin 2, conserved barrel domain protein
GTW28_10575	COG0456	acetyltransferase
GTW28_10580	COG1309	transcriptional regulator
GTW28_10585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GTW28_10590	COG3708	Transcriptional regulator
GTW28_10595	COG2378	regulation of single-species biofilm formation
GTW28_10605	COG0640	Transcriptional regulator
GTW28_10610	COG0741	lytic transglycosylase activity
GTW28_10615	COG2322	membrane
GTW28_10630	COG1619	proteins homologs of microcin C7 resistance protein MccF
GTW28_10635	COG3239	Fatty acid desaturase
GTW28_10640	COG4585	Histidine kinase
GTW28_10645	COG2197	response regulator
GTW28_10650	COG1388	LysM domain
GTW28_10650	COG3584	3D domain protein
GTW28_10655	COG0514	ATP-dependent DNA helicase (RecQ)
GTW28_10665	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GTW28_10670	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GTW28_10685	COG0071	Belongs to the small heat shock protein (HSP20) family
GTW28_10710	COG1012	belongs to the aldehyde dehydrogenase family
GTW28_10715	COG1657	PFAM Prenyltransferase squalene oxidase
GTW28_10720	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GTW28_10725	COG0733	neurotransmitter:sodium symporter activity
GTW28_10730	COG0385	Bile acid
GTW28_10735	COG0508	dehydrogenase complex catalyzes the overall conversion of
GTW28_10740	COG0567	Dehydrogenase, E1 component
GTW28_10745	COG4548	von Willebrand factor, type A
GTW28_10750	COG0714	Associated with various cellular activities
GTW28_10755	COG2032	superoxide dismutase activity
GTW28_10760	COG1388	LysM domain
GTW28_10760	COG0791	NLP P60 protein
GTW28_10765	COG1819	glycosyl
GTW28_10770	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GTW28_10775	COG0534	Mate efflux family protein
GTW28_10780	COG1366	Belongs to the anti-sigma-factor antagonist family
GTW28_10785	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GTW28_10790	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GTW28_10800	COG2962	Rard protein
GTW28_10815	COG2610	gluconate transmembrane transporter activity
GTW28_10820	COG1942	4-Oxalocrotonate Tautomerase
GTW28_10825	COG1733	regulation of RNA biosynthetic process
GTW28_10830	COG0778	Nitroreductase
GTW28_10835	COG0400	carboxylic ester hydrolase activity
GTW28_10840	COG0346	lactoylglutathione lyase activity
GTW28_10850	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GTW28_10855	COG0793	Belongs to the peptidase S41A family
GTW28_10855	COG3409	Peptidoglycan-binding domain 1 protein
GTW28_10860	COG2226	methyltransferase
GTW28_10870	COG1876	peptidase activity
GTW28_10875	COG0813	purine-nucleoside phosphorylase activity
GTW28_10890	COG0671	phosphoesterase, PA-phosphatase related
GTW28_10910	COG4479	Belongs to the UPF0346 family
GTW28_10920	COG1509	lysine 2,3-aminomutase activity
GTW28_10925	COG0456	acetyltransferase
GTW28_10930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GTW28_10935	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GTW28_10940	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GTW28_10945	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GTW28_10960	COG0456	acetyltransferase
GTW28_10965	COG0463	Glycosyl transferase, family 2
GTW28_10980	COG4641	Protein conserved in bacteria
GTW28_10985	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
GTW28_10990	COG1086	Polysaccharide biosynthesis protein
GTW28_10995	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GTW28_11000	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GTW28_11005	COG1846	Transcriptional regulator
GTW28_11010	COG0534	Mate efflux family protein
GTW28_11020	COG4698	Protein conserved in bacteria
GTW28_11025	COG2755	lipolytic protein G-D-S-L family
GTW28_11030	COG1999	signal sequence binding
GTW28_11040	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GTW28_11045	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GTW28_11050	COG1272	protein, Hemolysin III
GTW28_11055	COG0204	Acyl-transferase
GTW28_11060	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GTW28_11065	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GTW28_11070	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GTW28_11080	COG2521	methyltransferase
GTW28_11080	COG2136	Putative SAM-dependent methyltransferase
GTW28_11090	COG0129	dihydroxy-acid dehydratase activity
GTW28_11095	COG1413	lyase activity
GTW28_11100	COG1418	mRNA catabolic process
GTW28_11105	COG0386	Belongs to the glutathione peroxidase family
GTW28_11110	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GTW28_11115	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GTW28_11125	COG1278	Cold shock
GTW28_11145	COG0328	RNA-DNA hybrid ribonuclease activity
GTW28_11150	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GTW28_11155	COG0328	RNA-DNA hybrid ribonuclease activity
GTW28_11165	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GTW28_11180	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GTW28_11190	COG1755	Isoprenylcysteine carboxyl methyltransferase
GTW28_11195	COG3424	synthase
GTW28_11200	COG2233	PERMEase
GTW28_11205	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GTW28_11210	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GTW28_11220	COG0800	Aldolase
GTW28_11225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTW28_11230	COG1609	Transcriptional regulator
GTW28_11235	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GTW28_11240	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_11245	COG1199	ATP-dependent helicase activity
GTW28_11260	COG0116	Belongs to the methyltransferase superfamily
GTW28_11275	COG4474	Belongs to the UPF0398 family
GTW28_11290	COG3359	exonuclease
GTW28_11295	COG1205	dead DEAH box helicase
GTW28_11295	COG1111	helicase
GTW28_11300	COG2190	(PTS) system
GTW28_11305	COG0071	Belongs to the small heat shock protein (HSP20) family
GTW28_11340	COG3331	DNA recombination
GTW28_11345	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GTW28_11345	COG4499	WXG100 protein secretion system (Wss), protein YukC
GTW28_11355	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GTW28_11360	COG3935	DnaD domain protein
GTW28_11365	COG0017	Asparaginyl-tRNA synthetase
GTW28_11370	COG0436	Aminotransferase
GTW28_11375	COG5353	protein conserved in bacteria
GTW28_11385	COG1199	ATP-dependent helicase activity
GTW28_11385	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GTW28_11390	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GTW28_11395	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GTW28_11400	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GTW28_11405	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GTW28_11405	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GTW28_11410	COG0617	tRNA 3'-terminal CCA addition
GTW28_11415	COG0438	transferase activity, transferring glycosyl groups
GTW28_11420	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GTW28_11425	COG1803	Methylglyoxal synthase
GTW28_11430	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GTW28_11435	COG1694	Mazg nucleotide pyrophosphohydrolase
GTW28_11440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GTW28_11450	COG4347	Protein of unknown function (DUF1405)
GTW28_11455	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GTW28_11455	COG2010	Cytochrome c
GTW28_11460	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GTW28_11465	COG0723	plastoquinol--plastocyanin reductase activity
GTW28_11475	COG5582	Belongs to the UPF0302 family
GTW28_11480	COG0457	Tetratricopeptide repeat
GTW28_11485	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GTW28_11490	COG0287	Prephenate dehydrogenase
GTW28_11495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GTW28_11500	COG0159	tryptophan synthase activity
GTW28_11505	COG0133	tryptophan synthase activity
GTW28_11510	COG0135	phosphoribosylanthranilate isomerase activity
GTW28_11520	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GTW28_11525	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GTW28_11530	COG4401	Chorismate mutase type I
GTW28_11535	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GTW28_11540	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GTW28_11545	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GTW28_11550	COG0105	UTP biosynthetic process
GTW28_11555	COG0142	geranyltranstransferase activity
GTW28_11560	COG2226	methyltransferase
GTW28_11565	COG0142	geranyltranstransferase activity
GTW28_11575	COG0302	gtp cyclohydrolase
GTW28_11580	COG0776	regulation of translation
GTW28_11585	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GTW28_11600	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GTW28_11605	COG1160	GTP binding
GTW28_11630	COG1304	FMN binding
GTW28_11635	COG0539	negative regulation of cytoplasmic translation
GTW28_11640	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GTW28_11650	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
GTW28_11655	COG2959	enzyme of heme biosynthesis
GTW28_11660	COG3409	Peptidoglycan-binding domain 1 protein
GTW28_11660	COG3773	Cell wall hydrolase
GTW28_11665	COG2339	peptidase activity
GTW28_11670	COG0492	ferredoxin-NADP+ reductase activity
GTW28_11675	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GTW28_11680	COG4862	establishment of competence for transformation
GTW28_11685	COG1408	metallophosphoesterase
GTW28_11695	COG1388	LysM domain
GTW28_11700	COG1266	CAAX protease self-immunity
GTW28_11705	COG0514	ATP-dependent DNA helicase (RecQ)
GTW28_11710	COG4955	Helix-turn-helix domain
GTW28_11715	COG1141	Ferredoxin
GTW28_11720	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GTW28_11725	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GTW28_11730	COG0710	3-dehydroquinate dehydratase activity
GTW28_11740	COG1595	DNA-templated transcription, initiation
GTW28_11745	COG5002	protein histidine kinase activity
GTW28_11750	COG0745	RESPONSE REGULATOR receiver
GTW28_11755	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GTW28_11760	COG1333	cytochrome c biogenesis protein
GTW28_11765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GTW28_11770	COG1187	pseudouridine synthase activity
GTW28_11775	COG0700	Nucleoside recognition
GTW28_11780	COG2715	membrane protein required for spore maturation
GTW28_11785	COG1686	Belongs to the peptidase S11 family
GTW28_11795	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GTW28_11800	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GTW28_11805	COG1547	Domain of unknown function (DUF309)
GTW28_11810	COG0456	acetyltransferase
GTW28_11815	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GTW28_11820	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GTW28_11820	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GTW28_11825	COG0307	riboflavin synthase, alpha
GTW28_11830	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GTW28_11830	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GTW28_11840	COG0681	Belongs to the peptidase S26 family
GTW28_11850	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
GTW28_11900	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GTW28_11905	COG4086	secreted protein
GTW28_11910	COG0019	diaminopimelate decarboxylase activity
GTW28_11915	COG0697	spore germination
GTW28_11930	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GTW28_11950	COG1191	sigma factor activity
GTW28_11955	COG2172	sigma factor antagonist activity
GTW28_11960	COG1366	Belongs to the anti-sigma-factor antagonist family
GTW28_11965	COG1686	Belongs to the peptidase S11 family
GTW28_11970	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GTW28_11975	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GTW28_11980	COG4974	Belongs to the 'phage' integrase family
GTW28_11990	COG0735	belongs to the Fur family
GTW28_11995	COG1300	Membrane
GTW28_12005	COG0281	malic enzyme
GTW28_12010	COG1757	Na H antiporter
GTW28_12015	COG1027	Aspartate ammonia-lyase
GTW28_12020	COG0252	asparaginase activity
GTW28_12025	COG1396	sequence-specific DNA binding
GTW28_12030	COG1379	DNA repair
GTW28_12035	COG0494	nUDIX hydrolase
GTW28_12045	COG0667	Aldo Keto reductase
GTW28_12055	COG1073	alpha beta
GTW28_12065	COG4918	Iron-sulphur cluster biosynthesis
GTW28_12070	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GTW28_12070	COG0456	acetyltransferase
GTW28_12075	COG2329	Antibiotic biosynthesis monooxygenase
GTW28_12080	COG0456	acetyltransferase
GTW28_12090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GTW28_12100	COG2211	Major facilitator Superfamily
GTW28_12105	COG0346	lactoylglutathione lyase activity
GTW28_12110	COG1072	(Pantothenic acid kinase))
GTW28_12115	COG3048	D-serine ammonia-lyase activity
GTW28_12120	COG0300	oxidoreductase activity
GTW28_12125	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GTW28_12130	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GTW28_12135	COG4187	Peptidase family M20/M25/M40
GTW28_12140	COG1902	pentaerythritol trinitrate reductase activity
GTW28_12145	COG0596	Alpha beta hydrolase
GTW28_12155	COG1234	tRNA 3'-trailer cleavage
GTW28_12160	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GTW28_12165	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GTW28_12170	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GTW28_12180	COG0706	membrane insertase activity
GTW28_12185	COG3361	conserved protein (COG2071)
GTW28_12190	COG2195	Cleaves the N-terminal amino acid of tripeptides
GTW28_12195	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GTW28_12200	COG0346	lactoylglutathione lyase activity
GTW28_12210	COG1376	ErfK ybiS ycfS ynhG family protein
GTW28_12215	COG4129	membrane
GTW28_12220	COG1126	abc transporter atp-binding protein
GTW28_12225	COG0765	amino acid transport
GTW28_12230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTW28_12240	COG1597	lipid kinase activity
GTW28_12245	COG2814	Major facilitator Superfamily
GTW28_12250	COG4978	Transcriptional regulator
GTW28_12250	COG0789	Transcriptional regulator
GTW28_12255	COG0508	dehydrogenase complex catalyzes the overall conversion of
GTW28_12260	COG0022	dehydrogenase e1 component
GTW28_12265	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GTW28_12270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GTW28_12275	COG3426	butyrate kinase activity
GTW28_12280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GTW28_12285	COG0280	phosphate acetyltransferase
GTW28_12290	COG3829	transcription factor binding
GTW28_12290	COG3290	protein histidine kinase activity
GTW28_12300	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GTW28_12305	COG2079	MmgE PrpD family protein
GTW28_12310	COG0372	Belongs to the citrate synthase family
GTW28_12315	COG1960	acyl-CoA dehydrogenase activity
GTW28_12320	COG1250	3-hydroxyacyl-CoA dehydrogenase
GTW28_12325	COG0183	Belongs to the thiolase family
GTW28_12330	COG0584	glycerophosphoryl diester phosphodiesterase
GTW28_12335	COG0860	N-Acetylmuramoyl-L-alanine amidase
GTW28_12350	COG1902	pentaerythritol trinitrate reductase activity
GTW28_12355	COG0745	RESPONSE REGULATOR receiver
GTW28_12360	COG0750	zinc metalloprotease
GTW28_12365	COG0497	DNA recombination
GTW28_12370	COG1438	arginine binding
GTW28_12375	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GTW28_12380	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GTW28_12385	COG0142	geranyltranstransferase activity
GTW28_12390	COG1722	exodeoxyribonuclease VII activity
GTW28_12395	COG1570	exodeoxyribonuclease VII activity
GTW28_12400	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GTW28_12405	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GTW28_12410	COG1302	Protein conserved in bacteria
GTW28_12415	COG0439	Biotin carboxylase
GTW28_12420	COG0511	ligase activity, forming carbon-carbon bonds
GTW28_12460	COG3854	ATPases associated with a variety of cellular activities
GTW28_12470	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GTW28_12475	COG0006	proline dipeptidase activity
GTW28_12480	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GTW28_12490	COG3872	metal-dependent enzyme
GTW28_12500	COG1752	Esterase of the alpha-beta hydrolase superfamily
GTW28_12505	COG1321	iron dependent repressor
GTW28_12510	COG0095	Lipoate-protein ligase
GTW28_12515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GTW28_12520	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GTW28_12525	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GTW28_12530	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GTW28_12535	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GTW28_12550	COG1396	sequence-specific DNA binding
GTW28_12560	COG0681	Belongs to the peptidase S26 family
GTW28_12585	COG4940	Competence protein ComGF
GTW28_12595	COG4970	Tfp pilus assembly protein FimT
GTW28_12600	COG4537	Required for transformation and DNA binding
GTW28_12605	COG1459	type II secretion system
GTW28_12610	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GTW28_12615	COG0517	IMP dehydrogenase activity
GTW28_12620	COG0598	Magnesium transport protein CorA
GTW28_12625	COG1253	flavin adenine dinucleotide binding
GTW28_12630	COG1366	Belongs to the anti-sigma-factor antagonist family
GTW28_12640	COG1393	Belongs to the ArsC family
GTW28_12650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GTW28_12660	COG0011	TIGRFAM Protein of
GTW28_12670	COG2866	Carboxypeptidase
GTW28_12675	COG1368	sulfuric ester hydrolase activity
GTW28_12680	COG1940	carbohydrate kinase activity
GTW28_12685	COG4483	Protein conserved in bacteria
GTW28_12690	COG0705	Rhomboid family
GTW28_12690	COG0457	Tetratricopeptide repeat
GTW28_12700	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GTW28_12705	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GTW28_12710	COG0438	transferase activity, transferring glycosyl groups
GTW28_12725	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GTW28_12730	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GTW28_12735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GTW28_12740	COG0581	inorganic phosphate transmembrane transporter activity
GTW28_12745	COG0573	inorganic phosphate transmembrane transporter activity
GTW28_12750	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GTW28_12760	COG0477	Major facilitator Superfamily
GTW28_12765	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GTW28_12770	COG2839	Protein conserved in bacteria
GTW28_12775	COG5521	maltodextrose utilization protein MalA
GTW28_12780	COG1388	LysM domain
GTW28_12785	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GTW28_12790	COG4709	membrane
GTW28_12795	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
GTW28_12800	COG0735	belongs to the Fur family
GTW28_12805	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GTW28_12815	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GTW28_12820	COG0513	Belongs to the DEAD box helicase family
GTW28_12830	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GTW28_12835	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GTW28_12840	COG2384	SAM-dependent methyltransferase
GTW28_12845	COG2010	Cytochrome c
GTW28_12850	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GTW28_12855	COG0358	DNA primase activity
GTW28_12860	COG1671	Belongs to the UPF0178 family
GTW28_12865	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GTW28_12870	COG0517	IMP dehydrogenase activity
GTW28_12875	COG0751	glycine-tRNA ligase activity
GTW28_12880	COG0752	glycyl-tRNA synthetase alpha subunit
GTW28_12885	COG1381	Involved in DNA repair and RecF pathway recombination
GTW28_12895	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GTW28_12900	COG0295	cytidine deaminase activity
GTW28_12905	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GTW28_12910	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GTW28_12915	COG1480	7TM receptor with intracellular HD hydrolase
GTW28_12920	COG1702	phosphate starvation-inducible protein PhoH
GTW28_12925	COG0561	phosphatase activity
GTW28_12940	COG4864	UPF0365 protein
GTW28_12945	COG1030	water channel activity
GTW28_12950	COG1610	YqeY-like protein
GTW28_12955	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GTW28_12960	COG1283	sodium-dependent phosphate transmembrane transporter activity
GTW28_12965	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GTW28_12970	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GTW28_12975	COG2264	protein methyltransferase activity
GTW28_12980	COG0484	heat shock protein binding
GTW28_12985	COG0443	Heat shock 70 kDa protein
GTW28_12990	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GTW28_12995	COG1420	regulation of RNA biosynthetic process
GTW28_13000	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GTW28_13005	COG0481	GTPase activity
GTW28_13015	COG0860	N-Acetylmuramoyl-L-alanine amidase
GTW28_13020	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GTW28_13025	COG0268	Binds directly to 16S ribosomal RNA
GTW28_13030	COG1466	dna polymerase III delta subunit
GTW28_13045	COG0658	competence protein
GTW28_13045	COG2333	competence protein COMEC
GTW28_13050	COG2131	deaminase
GTW28_13055	COG1596	polysaccharide export
GTW28_13055	COG1555	photosystem II stabilization
GTW28_13060	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GTW28_13065	COG2226	methyltransferase
GTW28_13070	COG0799	negative regulation of ribosome biogenesis
GTW28_13075	COG1713	HD superfamily hydrolase involved in NAD metabolism
GTW28_13080	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GTW28_13085	COG1534	Rna-binding protein
GTW28_13090	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GTW28_13095	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GTW28_13100	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GTW28_13110	COG2755	lipolytic protein G-D-S-L family
GTW28_13115	COG3409	Peptidoglycan-binding domain 1 protein
GTW28_13115	COG5632	N-Acetylmuramoyl-L-alanine amidase
GTW28_13120	COG0398	Pfam SNARE associated Golgi protein
GTW28_13125	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GTW28_13135	COG3209	COG3209 Rhs family protein
GTW28_13145	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GTW28_13150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GTW28_13155	COG0798	PFAM Bile acid sodium symporter
GTW28_13160	COG0346	lactoylglutathione lyase activity
GTW28_13165	COG0640	Transcriptional regulator
GTW28_13170	COG3403	YqcI/YcgG family
GTW28_13175	COG0457	Tetratricopeptide repeat
GTW28_13190	COG5444	nuclease activity
GTW28_13210	COG3409	Peptidoglycan-binding domain 1 protein
GTW28_13210	COG5632	N-Acetylmuramoyl-L-alanine amidase
GTW28_13215	COG4824	toxin secretion phage lysis holin
GTW28_13245	COG3778	Protein conserved in bacteria
GTW28_13250	COG3299	homolog of phage Mu protein gp47
GTW28_13255	COG3628	GPW Gp25 family protein
GTW28_13265	COG4193	domain, Protein
GTW28_13270	COG1652	LysM domain
GTW28_13275	COG3953	SLT domain
GTW28_13275	COG5280	Phage tail tape measure protein TP901
GTW28_13340	COG4653	Phage capsid family
GTW28_13345	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GTW28_13355	COG2369	cell adhesion
GTW28_13360	COG5518	Phage portal protein
GTW28_13365	COG1783	phage Terminase large subunit
GTW28_13370	COG5484	DNA packaging
GTW28_13380	COG3677	Transposase
GTW28_13395	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
GTW28_13405	COG1484	DNA-dependent DNA replication
GTW28_13410	COG3935	DnaD domain protein
GTW28_13415	COG3723	Recombinational DNA repair protein, rece pathway
GTW28_13420	COG5377	YqaJ viral recombinase family
GTW28_13450	COG1476	TRANSCRIPTIONal
GTW28_13455	COG3620	sequence-specific DNA binding
GTW28_13465	COG0563	adenylate kinase activity
GTW28_13470	COG2856	Zn peptidase
GTW28_13490	COG4124	Belongs to the glycosyl hydrolase 26 family
GTW28_13495	COG0730	response to heat
GTW28_13500	COG0425	Belongs to the sulfur carrier protein TusA family
GTW28_13505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GTW28_13505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GTW28_13515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GTW28_13515	COG0425	Belongs to the sulfur carrier protein TusA family
GTW28_13525	COG2210	Belongs to the sulfur carrier protein TusA family
GTW28_13530	COG1937	Protein conserved in bacteria
GTW28_13535	COG0662	Cupin 2, conserved barrel domain protein
GTW28_13545	COG4978	Transcriptional regulator
GTW28_13545	COG0789	Transcriptional regulator
GTW28_13550	COG2814	Major facilitator Superfamily
GTW28_13555	COG0456	acetyltransferase
GTW28_13560	COG1253	flavin adenine dinucleotide binding
GTW28_13570	COG0697	spore germination
GTW28_13575	COG0583	DNA-binding transcription factor activity
GTW28_13580	COG2072	flavoprotein involved in K transport
GTW28_13585	COG1230	cation diffusion facilitator family transporter
GTW28_13590	COG1942	4-Oxalocrotonate Tautomerase
GTW28_13595	COG0583	DNA-binding transcription factor activity
GTW28_13605	COG1114	Component of the transport system for branched-chain amino acids
GTW28_13610	COG1687	branched-chain amino acid
GTW28_13615	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GTW28_13620	COG1522	sequence-specific DNA binding
GTW28_13625	COG2732	(Barnase) inhibitor
GTW28_13635	COG1335	isochorismatase
GTW28_13650	COG2318	DinB family
GTW28_13660	COG2070	2-Nitropropane dioxygenase
GTW28_13665	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GTW28_13685	COG3443	Belongs to the bacterial solute-binding protein 9 family
GTW28_13690	COG1595	DNA-templated transcription, initiation
GTW28_13695	COG0667	Aldo Keto reductase
GTW28_13700	COG2851	Citrate transporter
GTW28_13705	COG0583	DNA-binding transcription factor activity
GTW28_13710	COG2828	Protein conserved in bacteria
GTW28_13715	COG3409	Peptidoglycan-binding domain 1 protein
GTW28_13720	COG5566	PFAM Mor transcription activator
GTW28_13725	COG0596	Alpha beta hydrolase
GTW28_13730	COG4991	sh3 domain protein
GTW28_13735	COG4991	sh3 domain protein
GTW28_13745	COG0346	lactoylglutathione lyase activity
GTW28_13755	COG5577	PFAM Coat F domain
GTW28_13760	COG1063	alcohol dehydrogenase
GTW28_13770	COG5577	PFAM Coat F domain
GTW28_13775	COG0789	Transcriptional regulator
GTW28_13785	COG1064	alcohol dehydrogenase
GTW28_13790	COG0693	protein deglycase activity
GTW28_13795	COG1621	beta-fructofuranosidase activity
GTW28_13800	COG3716	PTS system mannose fructose sorbose family IID component
GTW28_13805	COG3715	PTS system
GTW28_13810	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTW28_13815	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTW28_13820	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GTW28_13820	COG3933	PFAM sigma-54 factor interaction domain-containing protein
GTW28_13830	COG1113	amino acid transport
GTW28_13835	COG1280	lysine exporter protein (LysE YggA)
GTW28_13840	COG1378	Sugar-specific transcriptional regulator TrmB
GTW28_13845	COG1595	DNA-templated transcription, initiation
GTW28_13855	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GTW28_13855	COG2755	lipolytic protein G-D-S-L family
GTW28_13880	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GTW28_13885	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GTW28_13890	COG2986	histidine ammonia-lyase
GTW28_13895	COG2084	Dehydrogenase
GTW28_13915	COG1131	(ABC) transporter
GTW28_13920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GTW28_13930	COG2124	cytochrome p450
GTW28_13930	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GTW28_13935	COG1309	transcriptional regulator
GTW28_13940	COG2226	methyltransferase
GTW28_13955	COG2116	formate transmembrane transporter activity
GTW28_13960	COG5609	conserved protein (DUF2294)
GTW28_13965	COG3383	formate dehydrogenase (NAD+) activity
GTW28_13970	COG2427	Protein of unknown function (DUF1641)
GTW28_13980	COG0626	cystathionine gamma-synthase activity
GTW28_13985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GTW28_13990	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GTW28_13995	COG2226	methyltransferase
GTW28_14010	COG0768	penicillin binding
GTW28_14015	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GTW28_14020	COG0572	uridine kinase
GTW28_14040	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GTW28_14045	COG3906	Belongs to the UPF0473 family
GTW28_14050	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GTW28_14055	COG4472	Bacterial protein of unknown function (DUF965)
GTW28_14060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GTW28_14065	COG0628	permease
GTW28_14070	COG1126	abc transporter atp-binding protein
GTW28_14075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTW28_14080	COG0765	amino acid transport
GTW28_14085	COG0765	amino acid transport
GTW28_14100	COG3881	PFAM PRC-barrel domain
GTW28_14105	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GTW28_14110	COG0457	Tetratricopeptide repeat
GTW28_14115	COG0482	sulfurtransferase activity
GTW28_14120	COG1104	cysteine desulfurase activity
GTW28_14125	COG1959	2 iron, 2 sulfur cluster binding
GTW28_14130	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GTW28_14135	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GTW28_14145	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GTW28_14150	COG0124	histidyl-tRNA synthetase
GTW28_14160	COG0860	N-Acetylmuramoyl-L-alanine amidase
GTW28_14160	COG3103	Sh3 type 3 domain protein
GTW28_14160	COG4991	sh3 domain protein
GTW28_14165	COG1490	D-aminoacyl-tRNA deacylase activity
GTW28_14170	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GTW28_14175	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GTW28_14180	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GTW28_14180	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GTW28_14185	COG5416	Lipopolysaccharide assembly protein A domain
GTW28_14190	COG0490	domain, Protein
GTW28_14195	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GTW28_14195	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GTW28_14205	COG2244	polysaccharide biosynthetic process
GTW28_14210	COG2323	membrane
GTW28_14220	COG1862	Preprotein translocase
GTW28_14225	COG0343	queuine tRNA-ribosyltransferase activity
GTW28_14230	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GTW28_14240	COG2255	four-way junction helicase activity
GTW28_14245	COG0632	four-way junction helicase activity
GTW28_14255	COG2814	Major facilitator Superfamily
GTW28_14260	COG0673	inositol 2-dehydrogenase activity
GTW28_14265	COG2112	serine threonine protein kinase
GTW28_14285	COG1115	amino acid carrier protein
GTW28_14290	COG0217	transcriptional regulatory protein
GTW28_14300	COG1388	LysM domain
GTW28_14305	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GTW28_14310	COG0157	Belongs to the NadC ModD family
GTW28_14315	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GTW28_14320	COG1104	cysteine desulfurase activity
GTW28_14325	COG1827	regulation of RNA biosynthetic process
GTW28_14330	COG0077	Prephenate dehydratase
GTW28_14335	COG4492	Belongs to the UPF0735 family
GTW28_14340	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GTW28_14345	COG3290	protein histidine kinase activity
GTW28_14355	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GTW28_14360	COG2868	ribosomal protein
GTW28_14365	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GTW28_14370	COG1994	Peptidase M50
GTW28_14375	COG0739	heme binding
GTW28_14380	COG2894	cell division
GTW28_14385	COG0850	regulation of cytokinetic process
GTW28_14390	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GTW28_14395	COG1792	Involved in formation and maintenance of cell shape
GTW28_14400	COG1077	Cell shape determining protein MreB Mrl
GTW28_14405	COG2003	Belongs to the UPF0758 family
GTW28_14410	COG0424	maF-like protein
GTW28_14420	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GTW28_14425	COG0285	dihydrofolate synthase activity
GTW28_14430	COG0525	valine-tRNA ligase activity
GTW28_14440	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GTW28_14445	COG1388	LysM domain
GTW28_14450	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GTW28_14455	COG0113	porphobilinogen synthase activity
GTW28_14460	COG1587	Uroporphyrinogen-III synthase
GTW28_14465	COG0181	hydroxymethylbilane synthase activity
GTW28_14470	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GTW28_14475	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GTW28_14485	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GTW28_14490	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GTW28_14495	COG0470	DNA polymerase III
GTW28_14495	COG1067	ATP-dependent peptidase activity
GTW28_14500	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GTW28_14505	COG0544	peptidyl-prolyl cis-trans isomerase activity
GTW28_14510	COG1477	protein flavinylation
GTW28_14510	COG0457	Tetratricopeptide repeat
GTW28_14515	COG0066	3-isopropylmalate dehydratase activity
GTW28_14520	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GTW28_14525	COG0473	3-isopropylmalate dehydrogenase activity
GTW28_14530	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GTW28_14535	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GTW28_14540	COG0440	acetolactate synthase activity
GTW28_14545	COG0028	Belongs to the TPP enzyme family
GTW28_14555	COG0454	-acetyltransferase
GTW28_14560	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
GTW28_14570	COG0622	Phosphoesterase
GTW28_14575	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GTW28_14580	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GTW28_14585	COG5401	PFAM Sporulation and spore germination
GTW28_14590	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GTW28_14595	COG1846	Transcriptional regulator
GTW28_14600	COG2197	response regulator
GTW28_14605	COG0824	Thioesterase
GTW28_14610	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GTW28_14615	COG1053	succinate dehydrogenase
GTW28_14620	COG2009	succinate dehydrogenase
GTW28_14625	COG1719	4-vinyl reductase, 4VR
GTW28_14630	COG0527	aspartate kinase activity
GTW28_14635	COG0322	excinuclease ABC activity
GTW28_14640	COG3118	belongs to the thioredoxin family
GTW28_14645	COG3534	alpha-L-arabinofuranosidase
GTW28_14650	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GTW28_14655	COG2086	electron transfer activity
GTW28_14660	COG1024	Enoyl-CoA hydratase
GTW28_14665	COG1309	transcriptional regulator
GTW28_14670	COG0318	PFAM AMP-dependent synthetase and ligase
GTW28_14675	COG3766	membrane
GTW28_14680	COG1193	negative regulation of DNA recombination
GTW28_14685	COG1796	DNA polymerase
GTW28_14685	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GTW28_14690	COG1286	toxin biosynthetic process
GTW28_14695	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GTW28_14700	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GTW28_14705	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTW28_14705	COG0072	phenylalanine-tRNA ligase activity
GTW28_14710	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GTW28_14720	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GTW28_14730	COG3835	regulator
GTW28_14735	COG0277	FAD linked oxidase domain protein
GTW28_14740	COG0247	lactate metabolic process
GTW28_14745	COG0346	lactoylglutathione lyase activity
GTW28_14755	COG1966	Carbon starvation protein
GTW28_14760	COG3534	alpha-L-arabinofuranosidase
GTW28_14765	COG0395	ABC-type sugar transport system, permease component
GTW28_14770	COG1175	transmembrane transport
GTW28_14775	COG1653	transport
GTW28_14780	COG0371	Dehydrogenase
GTW28_14785	COG0647	UMP catabolic process
GTW28_14790	COG0235	Class ii aldolase
GTW28_14795	COG1069	ribulokinase activity
GTW28_14800	COG2160	L-arabinose isomerase activity
GTW28_14805	COG3507	Belongs to the glycosyl hydrolase 43 family
GTW28_14810	COG1363	Peptidase, m42
GTW28_14820	COG3326	Membrane
GTW28_14825	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GTW28_14830	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GTW28_14835	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GTW28_14845	COG1346	cytolysis
GTW28_14850	COG1380	Effector of murein hydrolase LrgA
GTW28_14855	COG3279	Response regulator of the LytR AlgR family
GTW28_14860	COG3275	phosphorelay sensor kinase activity
GTW28_14870	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GTW28_14880	COG0398	Pfam SNARE associated Golgi protein
GTW28_14885	COG1484	DNA-dependent DNA replication
GTW28_14890	COG3611	Membrane attachment protein
GTW28_14895	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GTW28_14900	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GTW28_14905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GTW28_14910	COG1733	regulation of RNA biosynthetic process
GTW28_14915	COG2814	Major facilitator Superfamily
GTW28_14920	COG0656	L-ascorbic acid biosynthetic process
GTW28_14925	COG0237	dephospho-CoA kinase activity
GTW28_14930	COG1971	Probably functions as a manganese efflux pump
GTW28_14935	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GTW28_14940	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GTW28_14940	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GTW28_14945	COG5002	protein histidine kinase activity
GTW28_14950	COG0745	RESPONSE REGULATOR receiver
GTW28_14955	COG0039	L-malate dehydrogenase activity
GTW28_14960	COG0538	isocitrate dehydrogenase activity
GTW28_14965	COG0372	Belongs to the citrate synthase family
GTW28_14970	COG2707	UPF0756 membrane protein
GTW28_14975	COG0628	permease
GTW28_14980	COG3030	protein affecting phage T7 exclusion by the F plasmid
GTW28_14985	COG0469	pyruvate kinase activity
GTW28_14990	COG0205	6-phosphofructokinase activity
GTW28_14995	COG0825	malonyl-CoA metabolic process
GTW28_15000	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GTW28_15005	COG0281	malic enzyme
GTW28_15010	COG0587	DNA-directed DNA polymerase activity
GTW28_15030	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GTW28_15040	COG4109	DRTGG domain
GTW28_15045	COG0730	response to heat
GTW28_15050	COG1473	amidohydrolase
GTW28_15055	COG0196	riboflavin kinase activity
GTW28_15060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GTW28_15065	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GTW28_15070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GTW28_15075	COG1126	abc transporter atp-binding protein
GTW28_15080	COG0765	amino acid transport
GTW28_15085	COG0765	amino acid transport
GTW28_15090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTW28_15095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTW28_15100	COG0454	-acetyltransferase
GTW28_15105	COG0583	DNA-binding transcription factor activity
GTW28_15110	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GTW28_15115	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_15125	COG0165	Argininosuccinate lyase
GTW28_15130	COG0137	argininosuccinate synthase activity
GTW28_15135	COG0521	Mo-molybdopterin cofactor biosynthetic process
GTW28_15140	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GTW28_15150	COG0827	DNA restriction-modification system
GTW28_15155	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GTW28_15160	COG3874	Sporulation protein YtfJ
GTW28_15170	COG1714	RDD family
GTW28_15175	COG0616	signal peptide processing
GTW28_15180	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GTW28_15185	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GTW28_15190	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GTW28_15200	COG0301	tRNA thio-modification
GTW28_15205	COG1104	cysteine desulfurase activity
GTW28_15210	COG1114	Component of the transport system for branched-chain amino acids
GTW28_15215	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GTW28_15220	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GTW28_15225	COG1309	transcriptional regulator
GTW28_15230	COG1956	GAF domain-containing protein
GTW28_15235	COG2203	Gaf domain
GTW28_15235	COG2199	diguanylate cyclase activity
GTW28_15245	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GTW28_15250	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GTW28_15255	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GTW28_15260	COG0454	-acetyltransferase
GTW28_15265	COG0517	IMP dehydrogenase activity
GTW28_15270	COG0123	including yeast histone deacetylase and acetoin utilization protein
GTW28_15275	COG1360	Flagellar Motor Protein
GTW28_15280	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GTW28_15285	COG1609	Transcriptional regulator
GTW28_15290	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GTW28_15290	COG1605	Chorismate mutase
GTW28_15295	COG3118	belongs to the thioredoxin family
GTW28_15300	COG4980	gas vesicle protein
GTW28_15305	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GTW28_15310	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GTW28_15315	COG1674	ftsk spoiiie
GTW28_15320	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GTW28_15325	COG4848	Belongs to the UPF0354 family
GTW28_15330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GTW28_15345	COG1363	Peptidase, m42
GTW28_15350	COG5584	Small secreted protein
GTW28_15355	COG0281	malic enzyme
GTW28_15360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GTW28_15365	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GTW28_15375	COG0510	thiamine kinase activity
GTW28_15380	COG1523	belongs to the glycosyl hydrolase 13 family
GTW28_15385	COG1597	lipid kinase activity
GTW28_15395	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GTW28_15400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GTW28_15405	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GTW28_15410	COG2252	PERMEase
GTW28_15415	COG4473	ABC transporter
GTW28_15420	COG1131	(ABC) transporter
GTW28_15425	COG1349	DNA-binding transcription factor activity
GTW28_15430	COG1187	pseudouridine synthase activity
GTW28_15435	COG2244	polysaccharide biosynthetic process
GTW28_15440	COG2081	HI0933 family
GTW28_15445	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GTW28_15455	COG5578	integral membrane protein
GTW28_15460	COG0673	inositol 2-dehydrogenase activity
GTW28_15465	COG1653	transport
GTW28_15470	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GTW28_15475	COG4209	transmembrane transport
GTW28_15480	COG2207	Transcriptional regulator
GTW28_15485	COG1653	transport
GTW28_15490	COG0395	ABC-type sugar transport system, permease component
GTW28_15495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GTW28_15500	COG2124	cytochrome p450
GTW28_15505	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GTW28_15515	COG0156	8-amino-7-oxononanoate synthase activity
GTW28_15520	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GTW28_15530	COG1073	alpha beta
GTW28_15555	COG1486	melibiose metabolic process
GTW28_15560	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GTW28_15565	COG0495	leucyl-tRNA aminoacylation
GTW28_15575	COG2202	Pas domain
GTW28_15575	COG1366	Belongs to the anti-sigma-factor antagonist family
GTW28_15580	COG2814	Major facilitator Superfamily
GTW28_15585	COG2433	Pfam Transposase IS66
GTW28_15590	COG0577	efflux transmembrane transporter activity
GTW28_15595	COG1136	(ABC) transporter
GTW28_15600	COG2205	protein histidine kinase activity
GTW28_15605	COG0745	RESPONSE REGULATOR receiver
GTW28_15610	COG0577	efflux transmembrane transporter activity
GTW28_15615	COG1136	(ABC) transporter
GTW28_15630	COG1131	(ABC) transporter
GTW28_15635	COG1725	Transcriptional regulator
GTW28_15650	COG1242	4 iron, 4 sulfur cluster binding
GTW28_15655	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GTW28_15665	COG2267	carboxylic ester hydrolase activity
GTW28_15670	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GTW28_15675	COG1113	amino acid transport
GTW28_15680	COG0367	asparagine synthase
GTW28_15685	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GTW28_15690	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GTW28_15700	COG1506	peptidase
GTW28_15705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GTW28_15710	COG1116	anion transmembrane transporter activity
GTW28_15715	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GTW28_15720	COG0494	nUDIX hydrolase
GTW28_15725	COG4824	toxin secretion phage lysis holin
GTW28_15730	COG0783	Belongs to the Dps family
GTW28_15745	COG1854	S-ribosylhomocysteine lyase activity
GTW28_15750	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GTW28_15755	COG0288	reversible hydration of carbon dioxide
GTW28_15760	COG0254	rRNA binding
GTW28_15765	COG1271	oxidase subunit
GTW28_15770	COG1294	oxidase, subunit
GTW28_15780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GTW28_15785	COG1321	iron dependent repressor
GTW28_15785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GTW28_15790	COG1121	(ABC) transporter
GTW28_15795	COG0803	Belongs to the bacterial solute-binding protein 9 family
GTW28_15800	COG4948	Mandelate Racemase Muconate Lactonizing
GTW28_15805	COG0318	PFAM AMP-dependent synthetase and ligase
GTW28_15810	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GTW28_15815	COG0596	Alpha beta hydrolase
GTW28_15820	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GTW28_15825	COG1169	isochorismate synthase
GTW28_15830	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GTW28_15835	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GTW28_15840	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GTW28_15845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GTW28_15850	COG0438	transferase activity, transferring glycosyl groups
GTW28_15860	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GTW28_15865	COG0438	transferase activity, transferring glycosyl groups
GTW28_15870	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GTW28_15875	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GTW28_15880	COG0058	SHG alpha-glucan phosphorylase activity
GTW28_15885	COG0297	glycogen (starch) synthase activity
GTW28_15890	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GTW28_15895	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GTW28_15900	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GTW28_16025	COG3859	Proton-coupled thiamine transporter YuaJ
GTW28_16030	COG1247	-acetyltransferase
GTW28_16035	COG2268	Band 7 protein
GTW28_16040	COG1585	Membrane protein implicated in regulation of membrane protease activity
GTW28_16045	COG2318	DinB family
GTW28_16055	COG1454	alcohol dehydrogenase
GTW28_16065	COG1510	regulation of RNA biosynthetic process
GTW28_16075	COG0569	domain protein
GTW28_16080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GTW28_16085	COG4682	membrane
GTW28_16090	COG1705	Flagellar rod assembly protein muramidase FlgJ
GTW28_16095	COG0477	Major facilitator Superfamily
GTW28_16100	COG5553	Cysteine dioxygenase type I
GTW28_16110	COG1968	undecaprenyl-diphosphatase activity
GTW28_16115	COG0628	permease
GTW28_16120	COG0673	inositol 2-dehydrogenase activity
GTW28_16125	COG4806	L-rhamnose isomerase
GTW28_16130	COG3254	rhamnose metabolic process
GTW28_16135	COG1070	Carbohydrate kinase
GTW28_16140	COG1349	DNA-binding transcription factor activity
GTW28_16145	COG3347	Dehydrogenase
GTW28_16145	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_16150	COG0840	transmembrane signaling receptor activity
GTW28_16155	COG0840	transmembrane signaling receptor activity
GTW28_16160	COG0840	transmembrane signaling receptor activity
GTW28_16165	COG0840	transmembrane signaling receptor activity
GTW28_16180	COG0432	Pfam Uncharacterised protein family UPF0047
GTW28_16190	COG0366	Alpha amylase catalytic
GTW28_16195	COG1253	flavin adenine dinucleotide binding
GTW28_16200	COG2738	Putative neutral zinc metallopeptidase
GTW28_16215	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GTW28_16230	COG0166	Belongs to the GPI family
GTW28_16235	COG1979	alcohol dehydrogenase
GTW28_16240	COG1979	alcohol dehydrogenase
GTW28_16245	COG2155	Conserved Protein
GTW28_16250	COG1098	S1 RNA binding domain
GTW28_16255	COG0436	Aminotransferase
GTW28_16260	COG1522	sequence-specific DNA binding
GTW28_16265	COG2267	carboxylic ester hydrolase activity
GTW28_16275	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GTW28_16280	COG2205	protein histidine kinase activity
GTW28_16290	COG5018	Exonuclease
GTW28_16300	COG2814	Major facilitator Superfamily
GTW28_16305	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GTW28_16310	COG3011	Protein conserved in bacteria
GTW28_16320	COG3290	protein histidine kinase activity
GTW28_16325	COG4565	transcriptional regulatory protein
GTW28_16350	COG3493	citrate carrier protein
GTW28_16360	COG2111	Na H antiporter
GTW28_16360	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GTW28_16365	COG2111	Na H antiporter
GTW28_16370	COG1006	Multisubunit Na H antiporter MnhC subunit
GTW28_16375	COG0651	ATP synthesis coupled electron transport
GTW28_16380	COG1863	multisubunit Na H antiporter MnhE subunit
GTW28_16385	COG2212	antiporter activity
GTW28_16390	COG1320	monovalent cation:proton antiporter activity
GTW28_16395	COG2050	protein possibly involved in aromatic compounds catabolism
GTW28_16400	COG2197	response regulator
GTW28_16415	COG0142	geranyltranstransferase activity
GTW28_16435	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GTW28_16440	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GTW28_16445	COG1335	isochorismatase
GTW28_16450	COG5506	Protein of unknown function (DUF1694)
GTW28_16465	COG0628	permease
GTW28_16480	COG1418	mRNA catabolic process
GTW28_16485	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_16495	COG1511	domain protein
GTW28_16500	COG1674	ftsk spoiiie
GTW28_16500	COG0433	COG0433 Predicted ATPase
GTW28_16505	COG4499	WXG100 protein secretion system (Wss), protein YukC
GTW28_16510	COG5417	Belongs to the EsaB family
GTW28_16515	COG4842	Belongs to the WXG100 family
GTW28_16520	COG2508	Transcriptional regulator
GTW28_16520	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GTW28_16525	COG0686	Belongs to the AlaDH PNT family
GTW28_16530	COG5634	Uncharacterized conserved protein (DUF2278)
GTW28_16535	COG3251	PFAM MbtH domain protein
GTW28_16540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GTW28_16545	COG3433	isochorismatase activity
GTW28_16545	COG1535	isochorismatase
GTW28_16550	COG1021	2,3-dihydroxybenzoate-AMP ligase
GTW28_16555	COG1169	isochorismate synthase
GTW28_16560	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_16565	COG2819	hydrolase of the alpha beta superfamily
GTW28_16570	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GTW28_16575	COG1268	BioY protein
GTW28_16580	COG2056	Na+-H+ antiporter family
GTW28_16585	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GTW28_16590	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GTW28_16595	COG3584	3D domain protein
GTW28_16610	COG1252	NADH dehydrogenase
GTW28_16615	COG0492	ferredoxin-NADP+ reductase activity
GTW28_16625	COG0516	GMP reductase activity
GTW28_16630	COG2808	Putative FMN-binding domain
GTW28_16635	COG0456	acetyltransferase
GTW28_16640	COG0316	Belongs to the HesB IscA family
GTW28_16645	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GTW28_16650	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GTW28_16655	COG4844	belongs to the
GTW28_16660	COG1252	NADH dehydrogenase
GTW28_16665	COG4837	Protein of unknown function (DUF1462)
GTW28_16670	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GTW28_16675	COG0823	Involved in the tonB-independent uptake of proteins
GTW28_16675	COG1506	peptidase
GTW28_16675	COG4946	Tricorn protease homolog
GTW28_16680	COG0083	homoserine kinase activity
GTW28_16685	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GTW28_16690	COG0460	homoserine dehydrogenase
GTW28_16695	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GTW28_16700	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GTW28_16705	COG0647	UMP catabolic process
GTW28_16710	COG2445	Protein of unknown function DUF86
GTW28_16715	COG4470	Protein conserved in bacteria
GTW28_16725	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GTW28_16730	COG0739	heme binding
GTW28_16740	COG3377	Domain of unknown function (DUF1805)
GTW28_16745	COG0737	Belongs to the 5'-nucleotidase family
GTW28_16750	COG0730	response to heat
GTW28_16755	COG1801	Protein of unknown function DUF72
GTW28_16765	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GTW28_16770	COG2508	Transcriptional regulator
GTW28_16775	COG2233	PERMEase
GTW28_16780	COG2233	PERMEase
GTW28_16785	COG3195	allantoin biosynthetic process
GTW28_16785	COG3648	Uricase
GTW28_16790	COG2351	hydroxyisourate hydrolase activity
GTW28_16800	COG2080	2 iron, 2 sulfur cluster binding
GTW28_16805	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GTW28_16810	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GTW28_16815	COG2068	MobA-Related Protein
GTW28_16820	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GTW28_16825	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GTW28_16830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GTW28_16840	COG2356	endonuclease I
GTW28_16845	COG3842	ATPase activity
GTW28_16850	COG2188	Transcriptional regulator
GTW28_16855	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTW28_16860	COG0395	ABC-type sugar transport system, permease component
GTW28_16865	COG1175	transmembrane transport
GTW28_16870	COG1653	transport
GTW28_16875	COG2222	sugar isomerase
GTW28_16880	COG0322	excinuclease ABC activity
GTW28_16885	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GTW28_16900	COG0346	lactoylglutathione lyase activity
GTW28_16905	COG0640	Transcriptional regulator
GTW28_16910	COG0719	Fe-S assembly protein
GTW28_16915	COG0822	iron-sulfur transferase activity
GTW28_16920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GTW28_16925	COG0719	Fe-S assembly protein
GTW28_16930	COG0396	ATPase activity
GTW28_16940	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GTW28_16945	COG1464	Belongs to the NlpA lipoprotein family
GTW28_16950	COG2011	ABC-type metal ion transport system permease component
GTW28_16955	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GTW28_16965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GTW28_16970	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GTW28_16980	COG0509	glycine decarboxylation via glycine cleavage system
GTW28_16985	COG1393	Belongs to the ArsC family
GTW28_16990	COG1960	acyl-CoA dehydrogenase activity
GTW28_16995	COG0183	Belongs to the thiolase family
GTW28_17000	COG1024	Enoyl-CoA hydratase
GTW28_17000	COG1250	3-hydroxyacyl-CoA dehydrogenase
GTW28_17010	COG0506	proline dehydrogenase activity
GTW28_17020	COG5577	PFAM Coat F domain
GTW28_17025	COG1846	Transcriptional regulator
GTW28_17030	COG0477	Major facilitator Superfamily
GTW28_17035	COG1942	4-Oxalocrotonate Tautomerase
GTW28_17040	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_17045	COG0583	DNA-binding transcription factor activity
GTW28_17055	COG1120	ATPase activity
GTW28_17070	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_17075	COG0783	Belongs to the Dps family
GTW28_17080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GTW28_17085	COG0745	RESPONSE REGULATOR receiver
GTW28_17090	COG2770	Histidine kinase
GTW28_17090	COG2205	protein histidine kinase activity
GTW28_17100	COG1309	transcriptional regulator
GTW28_17105	COG0114	fumarate hydratase activity
GTW28_17115	COG0697	spore germination
GTW28_17120	COG0814	amino acid
GTW28_17130	COG2197	response regulator
GTW28_17135	COG4585	Histidine kinase
GTW28_17140	COG4758	membrane
GTW28_17145	COG3595	metallopeptidase activity
GTW28_17150	COG1842	Phage shock protein A
GTW28_17155	COG4758	membrane
GTW28_17160	COG2814	Major facilitator Superfamily
GTW28_17165	COG2096	Adenosyltransferase
GTW28_17170	COG1120	ATPase activity
GTW28_17175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTW28_17180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GTW28_17185	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_17190	COG3386	PFAM SMP-30 Gluconolaconase
GTW28_17195	COG2205	protein histidine kinase activity
GTW28_17200	COG0745	RESPONSE REGULATOR receiver
GTW28_17210	COG1191	sigma factor activity
GTW28_17220	COG2140	Oxalate decarboxylase
GTW28_17230	COG0577	efflux transmembrane transporter activity
GTW28_17235	COG1136	(ABC) transporter
GTW28_17240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GTW28_17245	COG1120	ATPase activity
GTW28_17250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTW28_17255	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GTW28_17260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GTW28_17265	COG0531	amino acid
GTW28_17275	COG1988	membrane-bound metal-dependent
GTW28_17280	COG1368	sulfuric ester hydrolase activity
GTW28_17285	COG1910	domain protein
GTW28_17290	COG0725	ABC transporter, periplasmic molybdate-binding protein
GTW28_17295	COG4149	molybdate abc transporter
GTW28_17300	COG0656	L-ascorbic acid biosynthetic process
GTW28_17310	COG0025	NhaP-type Na H and K H
GTW28_17315	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GTW28_17320	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GTW28_17325	COG3973	AAA domain
GTW28_17330	COG2860	membrane
GTW28_17335	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GTW28_17340	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GTW28_17345	COG2217	Heavy metal translocating P-type atpase
GTW28_17350	COG2217	Heavy metal translocating P-type atpase
GTW28_17355	COG2608	mercury ion transmembrane transporter activity
GTW28_17360	COG1937	Protein conserved in bacteria
GTW28_17365	COG0673	inositol 2-dehydrogenase activity
GTW28_17370	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GTW28_17375	COG1289	transmembrane transporter activity
GTW28_17385	COG2076	Multidrug Resistance protein
GTW28_17390	COG1309	transcriptional regulator
GTW28_17395	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_17405	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GTW28_17410	COG0557	exoribonuclease II activity
GTW28_17415	COG1647	Serine aminopeptidase, S33
GTW28_17420	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GTW28_17425	COG0596	Alpha beta hydrolase
GTW28_17430	COG1476	TRANSCRIPTIONal
GTW28_17435	COG1396	sequence-specific DNA binding
GTW28_17440	COG1396	sequence-specific DNA binding
GTW28_17445	COG1733	regulation of RNA biosynthetic process
GTW28_17450	COG0840	transmembrane signaling receptor activity
GTW28_17455	COG1174	glycine betaine transport
GTW28_17460	COG1732	Glycine betaine
GTW28_17465	COG1174	glycine betaine transport
GTW28_17470	COG1125	glycine betaine transport
GTW28_17470	COG0517	IMP dehydrogenase activity
GTW28_17475	COG1510	regulation of RNA biosynthetic process
GTW28_17480	COG1174	glycine betaine transport
GTW28_17485	COG1732	Glycine betaine
GTW28_17490	COG1174	glycine betaine transport
GTW28_17495	COG0517	IMP dehydrogenase activity
GTW28_17495	COG1125	glycine betaine transport
GTW28_17500	COG1510	regulation of RNA biosynthetic process
GTW28_17505	COG2095	MarC family integral membrane protein
GTW28_17515	COG3064	Membrane
GTW28_17520	COG4640	response to antibiotic
GTW28_17525	COG0456	acetyltransferase
GTW28_17530	COG0148	phosphopyruvate hydratase activity
GTW28_17535	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GTW28_17540	COG0149	triose-phosphate isomerase activity
GTW28_17545	COG0126	phosphoglycerate kinase activity
GTW28_17550	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GTW28_17555	COG2390	Transcriptional regulator
GTW28_17560	COG2814	Major facilitator Superfamily
GTW28_17565	COG1609	Transcriptional regulator
GTW28_17570	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GTW28_17575	COG0583	DNA-binding transcription factor activity
GTW28_17580	COG0697	spore germination
GTW28_17585	COG1113	amino acid transport
GTW28_17590	COG3858	chitin binding
GTW28_17595	COG1556	Lactate utilization protein
GTW28_17600	COG1139	Iron-sulfur cluster binding protein
GTW28_17605	COG0247	lactate metabolic process
GTW28_17610	COG2197	response regulator
GTW28_17615	COG4585	Histidine kinase
GTW28_17620	COG0842	Transport permease protein
GTW28_17625	COG1131	(ABC) transporter
GTW28_17630	COG3867	Arabinogalactan endo-beta-1,4-galactanase
GTW28_17635	COG1874	Beta-galactosidase
GTW28_17640	COG3833	ABC-type maltose transport systems, permease component
GTW28_17645	COG1175	transmembrane transport
GTW28_17650	COG2182	Extracellular solute-binding protein
GTW28_17655	COG1609	Transcriptional regulator
GTW28_17660	COG2186	Transcriptional regulator
GTW28_17665	COG1620	l-lactate permease
GTW28_17670	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GTW28_17680	COG5039	Polysaccharide pyruvyl transferase
GTW28_17685	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GTW28_17690	COG0110	maltose O-acetyltransferase activity
GTW28_17695	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GTW28_17700	COG2244	polysaccharide biosynthetic process
GTW28_17705	COG1216	Glycosyl transferase, family 2
GTW28_17710	COG5039	Polysaccharide pyruvyl transferase
GTW28_17715	COG1216	Glycosyl transferase, family 2
GTW28_17725	COG0438	transferase activity, transferring glycosyl groups
GTW28_17730	COG1215	transferase activity, transferring glycosyl groups
GTW28_17735	COG0438	transferase activity, transferring glycosyl groups
GTW28_17740	COG1086	Polysaccharide biosynthesis protein
GTW28_17745	COG0489	protein tyrosine kinase activity
GTW28_17750	COG3944	biosynthesis protein
GTW28_17755	COG1396	sequence-specific DNA binding
GTW28_17760	COG2272	Belongs to the type-B carboxylesterase lipase family
GTW28_17770	COG3479	Phenolic acid decarboxylase
GTW28_17785	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GTW28_17790	COG1621	beta-fructofuranosidase activity
GTW28_17795	COG1621	beta-fructofuranosidase activity
GTW28_17800	COG0531	amino acid
GTW28_17805	COG1309	transcriptional regulator
GTW28_17810	COG2076	Multidrug Resistance protein
GTW28_17815	COG2076	Multidrug Resistance protein
GTW28_17825	COG0277	FAD linked oxidase domain protein
GTW28_17830	COG3621	Patatin-like phospholipase
GTW28_17840	COG0740	serine-type endopeptidase activity
GTW28_17845	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GTW28_17850	COG0366	Alpha amylase catalytic
GTW28_17855	COG1554	hydrolase, family 65, central catalytic
GTW28_17860	COG5521	maltodextrose utilization protein MalA
GTW28_17865	COG3833	ABC-type maltose transport systems, permease component
GTW28_17870	COG1175	transmembrane transport
GTW28_17875	COG2182	Extracellular solute-binding protein
GTW28_17880	COG0366	Alpha amylase catalytic
GTW28_17885	COG1609	Transcriptional regulator
GTW28_17890	COG1611	Belongs to the LOG family
GTW28_17895	COG1694	Mazg nucleotide pyrophosphohydrolase
GTW28_17900	COG0659	secondary active sulfate transmembrane transporter activity
GTW28_17905	COG0288	reversible hydration of carbon dioxide
GTW28_17910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GTW28_17915	COG0577	efflux transmembrane transporter activity
GTW28_17920	COG1136	(ABC) transporter
GTW28_17925	COG5002	protein histidine kinase activity
GTW28_17930	COG0745	RESPONSE REGULATOR receiver
GTW28_17940	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GTW28_17945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTW28_17950	COG1481	regulation of sporulation
GTW28_17955	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GTW28_17960	COG1660	Displays ATPase and GTPase activities
GTW28_17965	COG1051	belongs to the nudix hydrolase family
GTW28_17970	COG0492	ferredoxin-NADP+ reductase activity
GTW28_17975	COG0791	NLP P60 protein
GTW28_17975	COG3883	PFAM NLP P60 protein
GTW28_17980	COG0457	Tetratricopeptide repeat
GTW28_17985	COG1132	(ABC) transporter
GTW28_18005	COG0140	phosphoribosyl-ATP diphosphatase activity
GTW28_18005	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GTW28_18010	COG0107	imidazoleglycerol-phosphate synthase activity
GTW28_18015	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GTW28_18020	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GTW28_18025	COG0131	Imidazoleglycerol-phosphate dehydratase
GTW28_18030	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GTW28_18035	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GTW28_18040	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GTW28_18045	COG4990	cell redox homeostasis
GTW28_18050	COG5297	Belongs to the glycosyl hydrolase family 6
GTW28_18055	COG0110	maltose O-acetyltransferase activity
GTW28_18060	COG0546	phosphoglycolate phosphatase activity
GTW28_18065	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GTW28_18070	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GTW28_18075	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GTW28_18080	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GTW28_18085	COG0363	glucosamine-6-phosphate deaminase activity
GTW28_18095	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GTW28_18100	COG1846	Transcriptional regulator
GTW28_18105	COG2124	cytochrome p450
GTW28_18115	COG1846	Transcriptional regulator
GTW28_18120	COG2814	Major facilitator Superfamily
GTW28_18125	COG1950	PFAM Membrane protein of
GTW28_18130	COG1983	PspC domain protein
GTW28_18135	COG3595	metallopeptidase activity
GTW28_18155	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GTW28_18160	COG0556	nucleotide-excision repair
GTW28_18165	COG4897	Protein conserved in bacteria
GTW28_18170	COG3848	Pyruvate phosphate dikinase
GTW28_18170	COG0574	Belongs to the PEP-utilizing enzyme family
GTW28_18175	COG1309	transcriptional regulator
GTW28_18180	COG2814	Major facilitator Superfamily
GTW28_18185	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GTW28_18195	COG3409	Peptidoglycan-binding domain 1 protein
GTW28_18195	COG0793	Belongs to the peptidase S41A family
GTW28_18200	COG2177	Part of the ABC transporter FtsEX involved in
GTW28_18205	COG2884	Cell division ATP-binding protein ftsE
GTW28_18210	COG2010	Cytochrome c
GTW28_18215	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GTW28_18225	COG0653	protein targeting
GTW28_18230	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GTW28_18245	COG1516	flagellar protein fliS
GTW28_18250	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GTW28_18255	COG1334	flagellar protein FlaG
GTW28_18260	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GTW28_18265	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GTW28_18270	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GTW28_18280	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GTW28_18285	COG4786	Flagellar basal body rod
GTW28_18285	COG1256	bacterial-type flagellum assembly
GTW28_18290	COG3418	PFAM FlgN family protein
GTW28_18295	COG2747	anti-sigma28 factor FlgM
GTW28_18305	COG1040	competence protein
GTW28_18315	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GTW28_18320	COG1307	EDD domain protein, DegV family
GTW28_18325	COG2197	response regulator
GTW28_18330	COG4585	Histidine kinase
GTW28_18335	COG1739	Uncharacterized protein family UPF0029
GTW28_18340	COG1316	TRANSCRIPTIONal
GTW28_18345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GTW28_18350	COG0438	transferase activity, transferring glycosyl groups
GTW28_18355	COG1215	transferase activity, transferring glycosyl groups
GTW28_18360	COG3206	protein involved in exopolysaccharide biosynthesis
GTW28_18365	COG3307	-O-antigen
GTW28_18370	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GTW28_18375	COG0297	glycogen (starch) synthase activity
GTW28_18375	COG0438	transferase activity, transferring glycosyl groups
GTW28_18380	COG2244	polysaccharide biosynthetic process
GTW28_18390	COG0860	N-Acetylmuramoyl-L-alanine amidase
GTW28_18390	COG2247	cell wall binding repeat
GTW28_18395	COG2385	sporulation resulting in formation of a cellular spore
GTW28_18395	COG2247	cell wall binding repeat
GTW28_18405	COG1316	TRANSCRIPTIONal
GTW28_18410	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GTW28_18415	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GTW28_18425	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GTW28_18425	COG1215	transferase activity, transferring glycosyl groups
GTW28_18430	COG0463	Glycosyl transferase, family 2
GTW28_18450	COG1134	teichoic acid transport
GTW28_18455	COG1682	transport, permease protein
GTW28_18460	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GTW28_18465	COG0438	transferase activity, transferring glycosyl groups
GTW28_18470	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GTW28_18475	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GTW28_18480	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GTW28_18490	COG4193	domain, Protein
GTW28_18495	COG1482	cell wall glycoprotein biosynthetic process
GTW28_18500	COG0697	spore germination
GTW28_18505	COG0814	amino acid
GTW28_18515	COG2814	Major facilitator Superfamily
GTW28_18520	COG1316	TRANSCRIPTIONal
GTW28_18525	COG0561	phosphatase activity
GTW28_18530	COG0791	NLP P60 protein
GTW28_18540	COG2843	Capsule synthesis protein
GTW28_18550	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GTW28_18555	COG1609	Transcriptional regulator
GTW28_18560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTW28_18565	COG1869	D-ribose catabolic process
GTW28_18570	COG1129	ABC transporter
GTW28_18575	COG1172	Belongs to the binding-protein-dependent transport system permease family
GTW28_18580	COG1879	ABC-type sugar transport system periplasmic component
GTW28_18585	COG3103	Sh3 type 3 domain protein
GTW28_18595	COG2249	NAD(P)H dehydrogenase (quinone) activity
GTW28_18600	COG3527	Alpha-acetolactate decarboxylase
GTW28_18605	COG0028	Belongs to the TPP enzyme family
GTW28_18610	COG0583	DNA-binding transcription factor activity
GTW28_18615	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GTW28_18630	COG5337	Spore coat protein CotH
GTW28_18640	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GTW28_18650	COG0405	Gamma-glutamyltransferase
GTW28_18655	COG1522	sequence-specific DNA binding
GTW28_18660	COG2059	Chromate
GTW28_18665	COG2059	Chromate
GTW28_18675	COG0655	NAD(P)H dehydrogenase (quinone) activity
GTW28_18680	COG0583	DNA-binding transcription factor activity
GTW28_18710	COG5444	nuclease activity
GTW28_18730	COG3878	Protein conserved in bacteria
GTW28_18735	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GTW28_18740	COG4464	protein tyrosine phosphatase activity
GTW28_18745	COG0489	protein tyrosine kinase activity
GTW28_18750	COG3944	biosynthesis protein
GTW28_18760	COG4715	Zinc finger, swim domain protein
GTW28_18765	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GTW28_18770	COG0561	phosphatase activity
GTW28_18775	COG1349	DNA-binding transcription factor activity
GTW28_18780	COG0629	single-stranded DNA binding
GTW28_18795	COG3764	Sortase (surface protein transpeptidase)
GTW28_18805	COG2972	Histidine kinase
GTW28_18805	COG0745	RESPONSE REGULATOR receiver
GTW28_18810	COG1970	mechanosensitive ion channel activity
GTW28_18815	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GTW28_18820	COG0457	Tetratricopeptide repeat
GTW28_18825	COG4786	Flagellar basal body rod
GTW28_18830	COG4786	Flagellar basal body rod
GTW28_18835	COG1077	Cell shape determining protein MreB Mrl
GTW28_18840	COG1609	Transcriptional regulator
GTW28_18850	COG1846	Transcriptional regulator
GTW28_18855	COG2814	Major facilitator Superfamily
GTW28_18860	COG3420	alginic acid biosynthetic process
GTW28_18865	COG1953	Uracil, thiamine, allantoin
GTW28_18870	COG0477	Major facilitator Superfamily
GTW28_18875	COG1335	isochorismatase
GTW28_18885	COG0004	ammonium transporteR
GTW28_18890	COG0347	Belongs to the P(II) protein family
GTW28_18895	COG0671	phosphoesterase, PA-phosphatase related
GTW28_18905	COG0739	heme binding
GTW28_18910	COG1247	-acetyltransferase
GTW28_18930	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GTW28_18935	COG0789	Transcriptional regulator
GTW28_18945	COG2910	NAD(P)H-binding
GTW28_18950	COG1959	2 iron, 2 sulfur cluster binding
GTW28_18955	COG0804	urea catabolic process
GTW28_18960	COG0832	Belongs to the urease beta subunit family
GTW28_18965	COG0831	urea catabolic process
GTW28_18980	COG3237	CsbD-like
GTW28_18985	COG1994	Peptidase M50
GTW28_18990	COG0457	Tetratricopeptide repeat
GTW28_18995	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GTW28_19000	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GTW28_19010	COG2304	oxidoreductase activity
GTW28_19020	COG2304	oxidoreductase activity
GTW28_19025	COG2385	sporulation resulting in formation of a cellular spore
GTW28_19030	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GTW28_19040	COG4836	Membrane
GTW28_19050	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GTW28_19055	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GTW28_19060	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GTW28_19065	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GTW28_19070	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GTW28_19075	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GTW28_19080	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GTW28_19085	COG0356	it plays a direct role in the translocation of protons across the membrane
GTW28_19095	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GTW28_19100	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GTW28_19105	COG4475	Protein of unknown function (DUF436)
GTW28_19110	COG0698	ribose 5-phosphate isomerase
GTW28_19115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GTW28_19120	COG1971	Probably functions as a manganese efflux pump
GTW28_19125	COG0009	L-threonylcarbamoyladenylate synthase
GTW28_19130	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GTW28_19150	COG2890	protein-(glutamine-N5) methyltransferase activity
GTW28_19155	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GTW28_19160	COG0346	lactoylglutathione lyase activity
GTW28_19165	COG0789	Transcriptional regulator
GTW28_19170	COG0679	Auxin Efflux Carrier
GTW28_19175	COG0281	malic enzyme
GTW28_19180	COG1435	thymidine kinase activity
GTW28_19185	COG0254	rRNA binding
GTW28_19190	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GTW28_19200	COG1494	fructose-1,6-bisphosphatase
GTW28_19205	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GTW28_19210	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GTW28_19215	COG0191	fructose-bisphosphate aldolase activity
GTW28_19220	COG2204	response regulator
GTW28_19225	COG4821	SIS domain
GTW28_19230	COG0504	CTP synthase activity
GTW28_19235	COG3343	RNA polymerase activity
GTW28_19240	COG1960	acyl-CoA dehydrogenase activity
GTW28_19245	COG2181	nitrate reductase activity
GTW28_19245	COG0247	lactate metabolic process
GTW28_19250	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GTW28_19255	COG4294	response to UV
GTW28_19265	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GTW28_19270	COG1132	(ABC) transporter
GTW28_19275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GTW28_19285	COG2181	nitrate reductase activity
GTW28_19290	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GTW28_19295	COG1140	nitrate reductase beta subunit
GTW28_19300	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GTW28_19305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GTW28_19315	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GTW28_19320	COG2223	nitrite transmembrane transporter activity
GTW28_19325	COG0018	arginyl-trna synthetase
GTW28_19330	COG4506	Protein conserved in bacteria
GTW28_19345	COG0535	radical SAM domain protein
GTW28_19355	COG1131	(ABC) transporter
GTW28_19360	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GTW28_19365	COG0612	Peptidase, M16
GTW28_19370	COG0612	Peptidase, M16
GTW28_19380	COG3391	amine dehydrogenase activity
GTW28_19385	COG3391	amine dehydrogenase activity
GTW28_19395	COG0457	Tetratricopeptide repeat
GTW28_19410	COG0010	Belongs to the arginase family
GTW28_19415	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GTW28_19420	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GTW28_19435	COG1994	Peptidase M50
GTW28_19440	COG1942	4-Oxalocrotonate Tautomerase
GTW28_19445	COG1846	Transcriptional regulator
GTW28_19450	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GTW28_19455	COG0477	Major facilitator Superfamily
GTW28_19460	COG1959	2 iron, 2 sulfur cluster binding
GTW28_19465	COG3465	dGTPase activity
GTW28_19470	COG1078	dGTPase activity
GTW28_19475	COG4844	belongs to the
GTW28_19485	COG0697	spore germination
GTW28_19490	COG0095	Lipoate-protein ligase
GTW28_19495	COG0583	DNA-binding transcription factor activity
GTW28_19500	COG0280	phosphate acetyltransferase
GTW28_19510	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_19515	COG0436	Aminotransferase
GTW28_19520	COG2814	Major facilitator Superfamily
GTW28_19525	COG0151	Belongs to the GarS family
GTW28_19530	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_19535	COG1917	Cupin 2, conserved barrel domain protein
GTW28_19540	COG0077	Prephenate dehydratase
GTW28_19545	COG2814	Major facilitator Superfamily
GTW28_19550	COG0833	amino acid
GTW28_19555	COG4187	Peptidase family M20/M25/M40
GTW28_19560	COG1012	belongs to the aldehyde dehydrogenase family
GTW28_19565	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GTW28_19575	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GTW28_19580	COG1091	dTDP-4-dehydrorhamnose reductase activity
GTW28_19585	COG1088	dTDP-glucose 4,6-dehydratase activity
GTW28_19590	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GTW28_19595	COG3980	spore coat polysaccharide biosynthesis protein
GTW28_19600	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
GTW28_19605	COG2089	acid synthase
GTW28_19610	COG0456	acetyltransferase
GTW28_19615	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GTW28_19620	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GTW28_19625	COG0463	Glycosyl transferase, family 2
GTW28_19635	COG2363	Small membrane protein
GTW28_19640	COG2233	PERMEase
GTW28_19650	COG1012	belongs to the aldehyde dehydrogenase family
GTW28_19655	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GTW28_19660	COG1216	Glycosyl transferase, family 2
GTW28_19665	COG0351	phosphomethylpyrimidine kinase
GTW28_19675	COG1621	beta-fructofuranosidase activity
GTW28_19680	COG1263	PTS System
GTW28_19680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTW28_19685	COG2116	formate transmembrane transporter activity
GTW28_19690	COG3711	transcriptional antiterminator
GTW28_19700	COG1404	Belongs to the peptidase S8 family
GTW28_19705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GTW28_19710	COG0778	Nitroreductase
GTW28_19715	COG0772	Belongs to the SEDS family
GTW28_19725	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GTW28_19730	COG1845	cytochrome c oxidase, subunit III
GTW28_19735	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GTW28_19740	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GTW28_19745	COG2261	transglycosylase associated protein
GTW28_19750	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GTW28_19755	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GTW28_19760	COG2246	polysaccharide biosynthetic process
GTW28_19765	COG1309	transcriptional regulator
GTW28_19775	COG3162	membrane
GTW28_19780	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GTW28_19785	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GTW28_19790	COG2837	iron assimilation
GTW28_19795	COG2822	iron ion transport
GTW28_19800	COG0672	)-iron permease
GTW28_19805	COG0352	thiamine-phosphate diphosphorylase activity
GTW28_19810	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GTW28_19815	COG0583	DNA-binding transcription factor activity
GTW28_19820	COG1380	Effector of murein hydrolase LrgA
GTW28_19825	COG1346	cytolysis
GTW28_19830	COG2814	Major facilitator Superfamily
GTW28_19835	COG4895	conserved protein (DUF2196)
GTW28_19840	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GTW28_19845	COG0346	lactoylglutathione lyase activity
GTW28_19860	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTW28_19865	COG1404	Belongs to the peptidase S8 family
GTW28_19870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTW28_19870	COG1263	PTS System
GTW28_19875	COG3711	transcriptional antiterminator
GTW28_19880	COG1442	glycosyl transferase family 8
GTW28_19885	COG5522	Integral membrane protein (intg_mem_TP0381)
GTW28_19890	COG1846	Transcriptional regulator
GTW28_19895	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GTW28_19900	COG2234	aminopeptidase activity
GTW28_19915	COG2814	Major facilitator Superfamily
GTW28_19920	COG2357	RelA SpoT domain protein
GTW28_19925	COG1575	Belongs to the MenA family. Type 1 subfamily
GTW28_19940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GTW28_19945	COG1696	Membrane protein involved in D-alanine export
GTW28_19950	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GTW28_19955	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GTW28_19960	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GTW28_19965	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GTW28_19970	COG1486	melibiose metabolic process
GTW28_19975	COG1447	Phosphotransferase system cellobiose-specific component IIA
GTW28_19980	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTW28_19985	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GTW28_19990	COG3711	transcriptional antiterminator
GTW28_19990	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GTW28_20000	COG2094	Belongs to the DNA glycosylase MPG family
GTW28_20005	COG0753	catalase activity
GTW28_20010	COG2814	Major facilitator Superfamily
GTW28_20015	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GTW28_20020	COG1131	(ABC) transporter
GTW28_20040	COG1595	DNA-templated transcription, initiation
GTW28_20045	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GTW28_20050	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GTW28_20055	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GTW28_20060	COG4988	ABC transporter
GTW28_20065	COG1294	oxidase, subunit
GTW28_20070	COG1271	oxidase subunit
GTW28_20075	COG3493	citrate carrier protein
GTW28_20080	COG0501	Belongs to the peptidase M48B family
GTW28_20090	COG0726	polysaccharide deacetylase
GTW28_20095	COG3842	ATPase activity
GTW28_20100	COG2508	Transcriptional regulator
GTW28_20105	COG1012	belongs to the aldehyde dehydrogenase family
GTW28_20110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GTW28_20120	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GTW28_20130	COG4585	Histidine kinase
GTW28_20135	COG2197	response regulator
GTW28_20140	COG2195	Cleaves the N-terminal amino acid of tripeptides
GTW28_20150	COG4894	glucomannan catabolic process
GTW28_20155	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GTW28_20160	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GTW28_20165	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_20170	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GTW28_20175	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GTW28_20180	COG2610	gluconate transmembrane transporter activity
GTW28_20185	COG0500	methyltransferase
GTW28_20190	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GTW28_20205	COG0693	protein deglycase activity
GTW28_20205	COG0753	catalase activity
GTW28_20210	COG2851	Citrate transporter
GTW28_20215	COG2273	Hydrolase Family 16
GTW28_20220	COG3711	transcriptional antiterminator
GTW28_20230	COG2270	Major facilitator Superfamily
GTW28_20235	COG0513	Belongs to the DEAD box helicase family
GTW28_20240	COG3401	FG-GAP repeat protein
GTW28_20240	COG2755	lipolytic protein G-D-S-L family
GTW28_20295	COG3209	COG3209 Rhs family protein
GTW28_20300	COG0697	spore germination
GTW28_20305	COG0589	response to stress
GTW28_20310	COG2723	6-phospho-beta-galactosidase activity
GTW28_20315	COG1263	PTS System
GTW28_20315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GTW28_20315	COG2190	(PTS) system
GTW28_20330	COG5444	nuclease activity
GTW28_20345	COG3507	Belongs to the glycosyl hydrolase 43 family
GTW28_20360	COG2986	histidine ammonia-lyase
GTW28_20365	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GTW28_20370	COG1228	amidohydrolase
GTW28_20375	COG0010	Belongs to the arginase family
GTW28_20380	COG0833	amino acid
GTW28_20385	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GTW28_20390	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GTW28_20395	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GTW28_20400	COG2390	Transcriptional regulator
GTW28_20410	COG3192	ethanolamine utilization protein
GTW28_20415	COG2079	MmgE PrpD family protein
GTW28_20425	COG1126	abc transporter atp-binding protein
GTW28_20430	COG0765	amino acid transport
GTW28_20435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GTW28_20455	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GTW28_20460	COG0561	phosphatase activity
GTW28_20490	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GTW28_20495	COG5294	Protein conserved in bacteria
GTW28_20500	COG0577	efflux transmembrane transporter activity
GTW28_20505	COG1136	(ABC) transporter
GTW28_20510	COG2205	protein histidine kinase activity
GTW28_20515	COG0745	RESPONSE REGULATOR receiver
GTW28_20520	COG0191	fructose-bisphosphate aldolase activity
GTW28_20525	COG1082	Xylose isomerase domain protein TIM barrel
GTW28_20530	COG1082	Xylose isomerase domain protein TIM barrel
GTW28_20535	COG0673	inositol 2-dehydrogenase activity
GTW28_20540	COG2814	Major facilitator Superfamily
GTW28_20545	COG1082	Xylose isomerase domain protein TIM barrel
GTW28_20550	COG3962	Belongs to the TPP enzyme family
GTW28_20555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GTW28_20565	COG1012	belongs to the aldehyde dehydrogenase family
GTW28_20570	COG1349	DNA-binding transcription factor activity
GTW28_20575	COG0667	Aldo Keto reductase
GTW28_20590	COG2814	Major facilitator Superfamily
GTW28_20595	COG0326	Molecular chaperone. Has ATPase activity
GTW28_20605	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_20610	COG1309	transcriptional regulator
GTW28_20615	COG1012	belongs to the aldehyde dehydrogenase family
GTW28_20620	COG0456	acetyltransferase
GTW28_20625	COG2850	peptidyl-arginine hydroxylation
GTW28_20630	COG2226	methyltransferase
GTW28_20645	COG0367	asparagine synthase
GTW28_20650	COG2814	Major facilitator Superfamily
GTW28_20655	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GTW28_20665	COG1714	RDD family
GTW28_20670	COG2311	Membrane
GTW28_20675	COG1917	Cupin 2, conserved barrel domain protein
GTW28_20680	COG1309	transcriptional regulator
GTW28_20685	COG1028	Short-chain dehydrogenase reductase Sdr
GTW28_20690	COG1846	Transcriptional regulator
GTW28_20695	COG1380	Effector of murein hydrolase LrgA
GTW28_20700	COG1346	cytolysis
GTW28_20705	COG5039	Polysaccharide pyruvyl transferase
GTW28_20710	COG1929	Belongs to the glycerate kinase type-1 family
GTW28_20715	COG1802	Transcriptional regulator
GTW28_20720	COG1070	Carbohydrate kinase
GTW28_20725	COG2610	gluconate transmembrane transporter activity
GTW28_20730	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GTW28_20735	COG0450	alkyl hydroperoxide reductase
GTW28_20740	COG3634	alkyl hydroperoxide reductase activity
GTW28_20745	COG2723	6-phospho-beta-galactosidase activity
GTW28_20750	COG2190	(PTS) system
GTW28_20755	COG2188	Transcriptional regulator
GTW28_20765	COG1131	(ABC) transporter
GTW28_20770	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GTW28_20785	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GTW28_20800	COG1063	alcohol dehydrogenase
GTW28_20820	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
GTW28_20825	COG0456	acetyltransferase
GTW28_20830	COG0457	Tetratricopeptide repeat
GTW28_20840	COG0010	Belongs to the arginase family
GTW28_20845	COG0833	amino acid
GTW28_20850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GTW28_20870	COG5658	integral membrane protein
GTW28_20875	COG0640	Transcriptional regulator
GTW28_20880	COG3829	transcription factor binding
GTW28_20885	COG5002	protein histidine kinase activity
GTW28_20910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GTW28_20915	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GTW28_20920	COG4853	Protein conserved in bacteria
GTW28_20925	COG4863	YycH protein
GTW28_20930	COG5002	protein histidine kinase activity
GTW28_20935	COG0745	RESPONSE REGULATOR receiver
GTW28_20965	COG0346	lactoylglutathione lyase activity
GTW28_20970	COG0305	Participates in initiation and elongation during chromosome replication
GTW28_20985	COG3093	addiction module antidote protein HigA
GTW28_20990	COG2807	transmembrane transport
GTW28_20995	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GTW28_21000	COG0359	binds to the 23S rRNA
GTW28_21005	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GTW28_21010	COG4241	membrane
GTW28_21020	COG5577	PFAM Coat F domain
GTW28_21025	COG1733	regulation of RNA biosynthetic process
GTW28_21030	COG1227	inorganic diphosphatase activity
GTW28_21040	COG2271	Major facilitator Superfamily
GTW28_21045	COG0789	Transcriptional regulator
GTW28_21045	COG4978	Transcriptional regulator
GTW28_21055	COG4319	ketosteroid isomerase
GTW28_21060	COG1357	PFAM Pentapeptide repeats (8 copies)
GTW28_21065	COG2814	Major facilitator Superfamily
GTW28_21070	COG0583	DNA-binding transcription factor activity
GTW28_21075	COG2153	protein acetylation
GTW28_21085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GTW28_21090	COG1846	Transcriptional regulator
GTW28_21095	COG2153	protein acetylation
GTW28_21100	COG2364	Membrane
GTW28_21105	COG0456	acetyltransferase
GTW28_21110	COG2315	Protein conserved in bacteria
GTW28_21115	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GTW28_21125	COG2814	Major facilitator Superfamily
GTW28_21135	COG1331	Highly conserved protein containing a thioredoxin domain
GTW28_21140	COG1266	CAAX protease self-immunity
GTW28_21145	COG2814	Major facilitator Superfamily
GTW28_21145	COG0477	Major facilitator Superfamily
GTW28_21150	COG0110	maltose O-acetyltransferase activity
GTW28_21155	COG0346	lactoylglutathione lyase activity
GTW28_21160	COG1609	Transcriptional regulator
GTW28_21165	COG0708	Exodeoxyribonuclease III
GTW28_21170	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GTW28_21175	COG0629	single-stranded DNA binding
GTW28_21180	COG0360	Binds together with S18 to 16S ribosomal RNA
GTW28_21185	COG0012	GTP binding
GTW28_21190	COG0243	molybdopterin cofactor binding
GTW28_21195	COG4481	Protein conserved in bacteria
GTW28_21200	COG3949	Membrane
GTW28_21210	COG1475	DNA binding
GTW28_21215	COG1192	Involved in chromosome partitioning
GTW28_21225	COG1475	DNA binding
GTW28_21230	COG0357	Ribosomal RNA small subunit methyltransferase G
GTW28_21235	COG0445	tRNA wobble uridine modification
GTW28_21240	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GTW28_21245	COG1847	R3H domain protein
GTW28_21250	COG0706	membrane insertase activity
GTW28_21255	COG0594	ribonuclease P activity
GTW28_21260	COG0230	Belongs to the bacterial ribosomal protein bL34 family