locus-tag class description B7470_00025 ENOG4106U2H Protein of unknown function (DUF1360) B7470_00035 ENOG4105CEY Amp-dependent synthetase and ligase B7470_00040 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family B7470_00045 ENOG4108N2V aldose 1-epimerase B7470_00050 ENOG4107QJQ Mate efflux family protein B7470_00080 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) B7470_00085 ENOG4105SKE transcriptional Regulator LysR family B7470_00090 ENOG4105CB2 alcohol dehydrogenase B7470_00095 ENOG4105BZ8 glutamate synthase B7470_00100 ENOG4105CBC glutamate synthase B7470_00105 ENOG4105C5Q Transcriptional regulator B7470_00145 ENOG4108UB7 B7470_00150 ENOG41068WN B7470_00165 ENOG4105CJ1 ABC, transporter B7470_00175 ENOG4105IE8 Alpha-ketoglutarate permease B7470_00275 ENOG4105D06 uba thif-type nad fad binding protein B7470_00280 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) B7470_00315 ENOG4105UA4 acetyltransferase B7470_00330 ENOG4106ANW SMI1_KNR4 B7470_00335 ENOG4106BHF B7470_00350 ENOG4108Z7R Chaperone CsaA B7470_00355 ENOG4105FTV AraC Family Transcriptional Regulator B7470_00360 ENOG4108HJF gCN5-related N-acetyltransferase B7470_00370 ENOG4108W8B Beta-lactamase domain protein B7470_00380 ENOG4105D29 Helix-turn-helix type 11 domain protein B7470_00390 ENOG4105KTU Transcriptional regulator, arsr family B7470_00400 ENOG4108SJC Membrane B7470_00420 ENOG4105ECK Fatty Acid Desaturase B7470_00425 ENOG4108ZGX Histidine kinase B7470_00430 ENOG4108S01 response regulator B7470_00435 ENOG41069ER domain protein B7470_00440 ENOG4105C9U ATP-dependent DNA helicase RecQ B7470_00455 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) B7470_00460 ENOG4105SCY DNAK suppressor B7470_00500 ENOG4105C26 Dehydrogenase B7470_00505 ENOG4105EWU Squalene--hopene cyclase B7470_00510 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) B7470_00515 ENOG4105C8J )-transporter B7470_00520 ENOG4105C09 Bile acid B7470_00525 ENOG4105C7S Dehydrogenase B7470_00535 ENOG4107T89 von Willebrand factor, type A B7470_00540 ENOG4105GMT ATPase associated with various cellular activities aaa_5 B7470_00550 ENOG4105K4H Nlp p60 protein B7470_00555 ENOG41087PP glycosyltransferase MGT family B7470_00565 ENOG4107QMU Mate efflux family protein B7470_00570 ENOG4106SCS STAS domain B7470_00590 ENOG4105FR1 rard protein B7470_00610 ENOG41090U3 tautomerase B7470_00630 ENOG4105FBA Phospholipase Carboxylesterase B7470_00645 ENOG4105E1V na solute symporter B7470_00665 ENOG4108VXD carboxy-peptidase B7470_00670 ENOG4105D3A purine nucleoside phosphorylase DeoD-type B7470_00680 ENOG4106Z5R B7470_00685 ENOG410841Q phosphoesterase PA-phosphatase related protein B7470_00720 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein B7470_00725 ENOG4108TSC N-acetyltransferase B7470_00730 ENOG4107S4Y M20 DapE family protein YgeY B7470_00745 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) B7470_00780 ENOG4107T32 3-phytase (EC 3.1.3.8) B7470_00785 ENOG4105C5E polysaccharide biosynthesis protein B7470_00790 ENOG4105E0X reductase B7470_00795 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) B7470_00815 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) B7470_00825 ENOG4108KF3 Electron transport protein SCO1 SenC B7470_00835 ENOG4105C7B Threonine dehydratase B7470_00845 ENOG4108UT2 hemolysin iii B7470_00855 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) B7470_00870 ENOG4107YX5 Pfam:DUF548 B7470_00875 ENOG4108Y6J UPF0403 protein B7470_00880 ENOG4105C01 Dihydroxy-acid dehydratase B7470_00895 ENOG4108V06 Glutathione peroxidase B7470_00900 ENOG4105CVG Homoserine O-transsuccinylase B7470_00940 ENOG41081VK Ribonuclease B7470_00965 ENOG410890F Dynamin family B7470_00980 ENOG41065KQ synthase B7470_00985 ENOG4105C2W permease B7470_00990 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) B7470_00995 ENOG4105CTD carboxy-peptidase B7470_01000 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) B7470_01005 ENOG4108UHU Aldolase B7470_01010 ENOG4105D7K pfkb domain protein B7470_01015 ENOG4108M60 Transcriptional regulator B7470_01025 ENOG4105CHR reductase B7470_01030 ENOG4105DVT helicase B7470_01045 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) B7470_01060 ENOG4108UKS UPF0398 protein B7470_01070 ENOG4107X2U Inherit from COG: Exonuclease-like protein B7470_01075 ENOG4108I5C dEAD DEAH box helicase B7470_01125 ENOG4105BZ4 penicillin-binding protein B7470_01135 ENOG4105CSM endonuclease III B7470_01145 ENOG4105C5S asparaginyl-tRNA synthetase B7470_01150 ENOG4105CHM Aminotransferase B7470_01160 ENOG4105YAC B7470_01165 ENOG4105DVT helicase B7470_01170 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) B7470_01175 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) B7470_01180 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) B7470_01185 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase B7470_01190 ENOG4105DJ0 Poly(A) Polymerase B7470_01195 ENOG4105CPK Glycosyl transferase (Group 1 B7470_01200 ENOG4105FJR Lmbe family B7470_01205 ENOG4108Z5K methylglyoxal synthase B7470_01210 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) B7470_01215 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase B7470_01220 ENOG4108JYZ YitT family B7470_01240 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) B7470_01260 ENOG41068YB TPR repeat-containing protein B7470_01265 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase B7470_01285 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) B7470_01290 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase B7470_01300 ENOG4108I0Q anthranilate phosphoribosyltransferase B7470_01305 ENOG4105CRQ synthase (Component I) B7470_01310 ENOG4105KHN chorismate mutase B7470_01315 ENOG4105D49 3-dehydroquinate synthase B7470_01320 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase B7470_01325 ENOG4105BZU Histidine kinase B7470_01330 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) B7470_01335 ENOG4105EAH synthase B7470_01340 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) B7470_01345 ENOG4105XXQ heptaprenyl diphosphate synthase component I B7470_01355 ENOG4105EUJ GTP cyclohydrolase i B7470_01360 ENOG4105K70 DNA-binding protein B7470_01365 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) B7470_01380 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase B7470_01385 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) B7470_01390 ENOG41065D1 B7470_01395 ENOG4105S2F B7470_01410 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) B7470_01415 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) B7470_01420 ENOG4105CAT Cytidine monophosphate kinase B7470_01435 ENOG4105MSI germination protein ypeb B7470_01445 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) B7470_01450 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase B7470_01465 ENOG4107RGJ metallophosphoesterase B7470_01480 ENOG4105I7S Abortive infection protein B7470_01485 ENOG4105C9U ATP-dependent DNA helicase RecQ B7470_01490 ENOG4105T7X B7470_01500 ENOG4108SAX Membrane B7470_01505 ENOG4108JQ1 Dehydrogenase B7470_01510 ENOG4105FF2 Type I DHQase B7470_01525 ENOG4105BZU Histidine kinase B7470_01530 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7470_01535 ENOG4105CRE cytochrome C B7470_01540 ENOG4107TWT Cytochrome c biogenesis protein B7470_01550 ENOG4105FE9 pseudouridine synthase B7470_01560 ENOG4108JIC nucleoside recognition domain protein B7470_01565 ENOG4105DZ1 carboxypeptidase B7470_01575 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) B7470_01580 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) B7470_01595 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) B7470_01600 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) B7470_01605 ENOG4108R6K riboflavin synthase, subunit alpha B7470_01610 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) B7470_01620 ENOG4105C3F Signal peptidase i B7470_01630 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) B7470_01640 ENOG4107ZE5 PPIases accelerate the folding of proteins B7470_01730 ENOG4107ZE5 PPIases accelerate the folding of proteins B7470_01745 ENOG4105PTM secreted protein B7470_01750 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) B7470_01760 ENOG4105G6R Stage v sporulation protein ae B7470_01770 ENOG4105CZ3 stage V sporulation protein ad B7470_01775 ENOG41090VF Stage v sporulation protein ac B7470_01790 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B7470_01795 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) B7470_01800 ENOG41082AN stage II sporulation protein B7470_01805 ENOG4105DZ1 carboxypeptidase B7470_01810 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) B7470_01815 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) B7470_01820 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B7470_01830 ENOG4105I3K Ferric uptake regulator, Fur family B7470_01835 ENOG4105MZ9 stage II sporulation protein m B7470_01850 ENOG4105DFD Na H antiporter B7470_01855 ENOG4108IJ0 Aspartate ammonia-lyase B7470_01860 ENOG4105HDK L-asparaginase B7470_01865 ENOG4108IMY Transcriptional regulator B7470_01875 ENOG4108YZ4 nudix hydrolase B7470_01885 ENOG4105CPC Aldo Keto reductase B7470_01905 ENOG4106HZJ B7470_01910 ENOG4105RHY Pfam:UPF0157 B7470_01915 ENOG4105KAC Antibiotic biosynthesis monooxygenase B7470_01920 ENOG4108XET gCN5-related N-acetyltransferase B7470_01930 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) B7470_01940 ENOG4105E5W Transporter B7470_01950 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase B7470_01965 ENOG4108IXY short-chain dehydrogenase reductase B7470_01970 ENOG41069FQ Metallo-beta-lactamase superfamily B7470_01975 ENOG4105II7 pyrroline-5-carboxylate reductase B7470_01985 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase B7470_02005 ENOG410861F 50S ribosomal protein L33 B7470_02010 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) B7470_02015 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase B7470_02020 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) B7470_02025 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) B7470_02035 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) B7470_02040 ENOG4108NA0 Uncharacterized conserved protein (COG2071) B7470_02045 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) B7470_02055 ENOG4108ZVT methylmalonyl-coA epimerase B7470_02060 ENOG4108VZI ErfK ybiS ycfS ynhG family protein B7470_02065 ENOG4108QEG Membrane B7470_02070 ENOG4105CDA abc transporter atp-binding protein B7470_02075 ENOG4105E5Q amino acid AbC transporter B7470_02080 ENOG4108HW3 (ABC) transporter B7470_02085 ENOG4108Y6J UPF0403 protein B7470_02090 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) B7470_02105 ENOG4105C7S Dehydrogenase B7470_02110 ENOG4105CPP Dehydrogenase, E1 component B7470_02120 ENOG4105CKM Branched-chain carboxylic acid kinase B7470_02125 ENOG4107RDP Dehydrogenase B7470_02135 ENOG4108JUB Transcriptional regulator B7470_02140 ENOG4106CCJ Protein of unknown function (DUF2627) B7470_02145 ENOG4105CR4 methylisocitrate lyase B7470_02150 ENOG4105DXD 2-methylcitrate dehydratase B7470_02160 ENOG4105C1G acyl-Coa dehydrogenase B7470_02165 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase B7470_02175 ENOG4108QXE glycerophosphoryl diester phosphodiesterase B7470_02180 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase B7470_02190 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase B7470_02195 ENOG4107QQR Sporulation B7470_02205 ENOG4105S1Z Stage IV sporulation protein B B7470_02210 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) B7470_02215 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) B7470_02220 ENOG4105DX0 Hemolysin A B7470_02230 ENOG4105CTB Polyprenyl synthetase B7470_02235 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) B7470_02240 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) B7470_02245 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) B7470_02250 ENOG4105M7K Involved in the transcription termination process (By similarity) B7470_02255 ENOG4108ZSR alkaline shock protein B7470_02260 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase B7470_02285 ENOG410644B Stage III sporulation protein af B7470_02295 ENOG4105KQ4 Stage iii sporulation protein ad B7470_02300 ENOG4108CQH stage III sporulation protein AC B7470_02305 ENOG4105KR5 Stage iii sporulation protein B7470_02310 ENOG4105CD2 stage iii sporulation protein aa B7470_02320 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) B7470_02325 ENOG4105DC7 peptidase M24 B7470_02330 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) B7470_02340 ENOG4105CBJ Metal-dependent enzyme B7470_02355 ENOG4105KST dependent repressor B7470_02360 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) B7470_02365 ENOG4105WZW rhodanese family B7470_02370 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor B7470_02375 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor B7470_02380 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) B7470_02385 ENOG4105C0D helicase B7470_02400 ENOG4108IMY Transcriptional regulator B7470_02410 ENOG4105VFR signal peptidase B7470_02465 ENOG41080XP Cbs domain B7470_02475 ENOG4105C37 (CBS) domain B7470_02500 ENOG4105C5X domain protein B7470_02525 ENOG4105E0M Sulfatase B7470_02540 ENOG4107ZXI Rhomboid family B7470_02550 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase B7470_02555 ENOG4105WDJ 50S ribosomal protein L33 B7470_02575 ENOG41068DG YceG-like family B7470_02580 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) B7470_02585 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) B7470_02590 ENOG4105E2Z phosphate ABC transporter (Permease B7470_02595 ENOG4105C8U phosphate abc transporter B7470_02600 ENOG4105CVA phosphate B7470_02605 ENOG4107RF6 penicillin-binding protein B7470_02615 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) B7470_02620 ENOG4105SXS Protein of unknown function (DUF456) B7470_02635 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) B7470_02640 ENOG41063Y9 B7470_02645 ENOG4108U5J '-nucleotidase B7470_02650 ENOG4105N80 Ferric uptake regulator, Fur family B7470_02655 ENOG4108JYZ YitT family B7470_02660 ENOG41069ZM Protein of unknown function (DUF2624) B7470_02665 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) B7470_02680 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) B7470_02685 ENOG4105EGD dinuclear metal center protein, YbgI family B7470_02705 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B7470_02710 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) B7470_02715 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 B7470_02720 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) B7470_02730 ENOG4105C38 Glycyl-tRNA synthetase beta subunit B7470_02735 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit B7470_02740 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) B7470_02750 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) B7470_02755 ENOG4105KG3 cytidine deaminase B7470_02760 ENOG4107YR5 Diacylglycerol kinase B7470_02765 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) B7470_02770 ENOG4105CTJ Metal Dependent Phosphohydrolase B7470_02775 ENOG4105C9A Phoh family B7470_02780 ENOG4105EI1 sporulation protein yqfd B7470_02785 ENOG41068P3 sporulation protein YqfC B7470_02795 ENOG4105DI5 UPF0365 protein B7470_02800 ENOG4105F7J membrane-bound serine protease B7470_02805 ENOG4105KTH gatB Yqey B7470_02820 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) B7470_02825 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) B7470_02830 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) B7470_02840 ENOG4105CFG Acts as a chaperone (By similarity) B7470_02845 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ B7470_02850 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) B7470_02855 ENOG4105CSA Coproporphyrinogen iii oxidase B7470_02860 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) B7470_02870 ENOG4108ZRV stage ii sporulation protein p B7470_02875 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) B7470_02880 ENOG41082YS Binds directly to 16S ribosomal RNA B7470_02885 ENOG4105TQK DNA polymerase iii, delta' subunit B7470_02895 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 B7470_02900 ENOG4108UK2 deaminase B7470_02905 ENOG4105KQC Competence protein B7470_02915 ENOG4108D32 Methyltransferase B7470_02925 ENOG4108WF2 Metal Dependent Phosphohydrolase B7470_02930 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) B7470_02935 ENOG410812S Rna-binding protein B7470_02940 ENOG4105E2X shikimate dehydrogenase B7470_02945 ENOG4105CQW ribosome biogenesis GTPase YqeH B7470_02950 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase B7470_02965 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B7470_02970 ENOG41080BT SNARE associated Golgi B7470_02985 ENOG4105WFK nuclease B7470_02990 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B7470_03000 ENOG4105C9Q fumarate hydratase class II B7470_03005 ENOG4107RSM transcriptional regulator B7470_03075 ENOG4106QJ6 Integrase catalytic subunit B7470_03080 ENOG4105EN2 IstB domain-containing protein ATP-binding protein B7470_03140 ENOG41090E6 transcriptional regulator MERR family B7470_03155 ENOG4105C37 (CBS) domain B7470_03170 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family B7470_03175 ENOG4105H3G oxidoreductase B7470_03180 ENOG4105PGM cation diffusion facilitator family transporter B7470_03195 ENOG4105KMT branched-chain amino acid B7470_03205 ENOG4108ZRZ Transcriptional regulator (AsnC family) B7470_03210 ENOG41067XF inhibitor B7470_03230 ENOG41064BW Protein of unknown function (DUF2568) B7470_03240 ENOG41075D4 Aminoglycoside 6-adenylyltransferase B7470_03245 ENOG4105EA8 2-Nitropropane dioxygenase B7470_03260 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) B7470_03275 ENOG4108MEK Metal-binding protein YodA B7470_03280 ENOG410904A RNA polymerase B7470_03285 ENOG4105CPC Aldo Keto reductase B7470_03290 ENOG41083Q9 chitosanase B7470_03295 ENOG4105X5K response regulator receiver protein B7470_03300 ENOG4108VQT Alpha beta hydrolase fold protein B7470_03305 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein B7470_03310 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein B7470_03315 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase B7470_03325 ENOG4105PGS Spore coat protein B7470_03330 ENOG4105E2A Dehydrogenase B7470_03345 ENOG4105VUF Transcriptional regulator B7470_03355 ENOG4105DQ4 alcohol dehydrogenase B7470_03360 ENOG4108Z0Z intracellular protease Pfpi family B7470_03365 ENOG4108HKT sucrose-6-phosphate hydrolase B7470_03370 ENOG4105F3R pts system mannose fructose sorbose family iid B7470_03375 ENOG4105ETZ PTS System B7470_03380 ENOG4108IQ3 PTS system B7470_03385 ENOG4105YHU PTS system B7470_03390 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family B7470_03395 ENOG4105C85 amino acid B7470_03400 ENOG4105N14 lysine exporter protein LysE YggA B7470_03405 ENOG4108NGU Transcriptional regulator B7470_03410 ENOG4105JVQ RNA Polymerase B7470_03415 ENOG4108P49 AntiSigma factor B7470_03425 ENOG4105WDR B7470_03435 ENOG41082JN Transcriptional regulator B7470_03450 ENOG4105TMB Formate nitrite transporter B7470_03455 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) B7470_03460 ENOG4108JB9 formate dehydrogenase B7470_03480 ENOG4105C28 cystathionine B7470_03495 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) B7470_03510 ENOG4107XRG penicillin-binding protein B7470_03515 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) B7470_03520 ENOG4105DBI uridine monophosphokinase B7470_03525 ENOG4105CFP Peptidase U32 B7470_03530 ENOG4105XYU peptidase (U32 family) B7470_03535 ENOG4108VQJ O-methyltransferase B7470_03540 ENOG4105HHA aminodeoxychorismate lyase B7470_03545 ENOG4105VPH UPF0473 protein B7470_03550 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) B7470_03555 ENOG4105VBH UPF0297 protein B7470_03560 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) B7470_03565 ENOG4105C02 permease B7470_03570 ENOG4105CDA abc transporter atp-binding protein B7470_03575 ENOG4105CT1 (ABC) transporter B7470_03580 ENOG4105EAD ABC transporter B7470_03585 ENOG4105DRP amino acid AbC transporter B7470_03595 ENOG41060CR B7470_03605 ENOG4105C7H Helicase, RecD TraA family B7470_03615 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) B7470_03620 ENOG4105C3J Cysteine desulfurase B7470_03630 ENOG4105D1H recombination factor protein RarA B7470_03635 ENOG4105CUZ uba thif-type nad fad binding protein B7470_03645 ENOG4105C9M aspartyl-trna synthetase B7470_03650 ENOG4105CUT histidyl-tRNA synthetase B7470_03660 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase B7470_03670 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) B7470_03675 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) B7470_03680 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) B7470_03685 ENOG41067VP Protein of unknown function (DUF1049) B7470_03690 ENOG4105NCW Trka-c domain protein B7470_03695 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) B7470_03705 ENOG4105CKP Polysaccharide Biosynthesis Protein B7470_03710 ENOG4108QG2 Membrane B7470_03715 ENOG4105NAP B7470_03720 ENOG4105VIE preprotein translocase, subunit YajC B7470_03725 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) B7470_03730 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) B7470_03735 ENOG41061AI Protein of unknown function (DUF2905) B7470_03740 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) B7470_03745 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) B7470_03755 ENOG4105IE8 Alpha-ketoglutarate permease B7470_03760 ENOG4105CK5 oxidoreductase B7470_03780 ENOG4105BZG amino acid carrier protein B7470_03785 ENOG4105CDY transcriptional regulatory protein B7470_03795 ENOG4106678 morphogenetic protein associated with SpoVID B7470_03800 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) B7470_03805 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase B7470_03810 ENOG4108IYU L-aspartate oxidase B7470_03825 ENOG4105CQC Prephenate dehydratase B7470_03830 ENOG41090I5 UPF0735 ACT domain-containing protein B7470_03835 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control B7470_03845 ENOG4105K46 50S ribosomal protein l27 B7470_03850 ENOG4105X36 (ribosomal) protein B7470_03855 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) B7470_03870 ENOG4107QMS site-determining protein B7470_03875 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) B7470_03880 ENOG4105YHC Rod shape-determining protein MreD B7470_03885 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) B7470_03890 ENOG4105DFF Rod shape-determining protein mreb B7470_03895 ENOG4105W5Q DNA repair protein (RadC B7470_03900 ENOG4108Z03 MAF-like protein B7470_03910 ENOG4106A3R peptidase B7470_03915 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase B7470_03920 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) B7470_03930 ENOG4106AR7 Spore coat protein B7470_03935 ENOG41068KH stage VI sporulation protein D B7470_03940 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase B7470_03945 ENOG4105D52 delta-aminolevulinic acid dehydratase B7470_03955 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) B7470_03965 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) B7470_03975 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) B7470_03980 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) B7470_03985 ENOG4108IUQ atp-dependent protease B7470_03990 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) B7470_03995 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation B7470_04005 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) B7470_04010 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) B7470_04015 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) B7470_04020 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) B7470_04025 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase B7470_04030 ENOG4108ZP8 Acetolactate synthase small subunit B7470_04035 ENOG4105C7K acetolactate synthase B7470_04045 ENOG4105I4A GCN5-related N-acetyltransferase B7470_04050 ENOG4107KM7 Heat induced stress protein YflT B7470_04080 ENOG4107SCJ type I restriction enzyme EcoKI subunit R B7470_04105 ENOG4105M59 Phosphodiesterase, mj0936 family B7470_04110 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) B7470_04115 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) B7470_04120 ENOG4108XJQ germination protein B7470_04125 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) B7470_04130 ENOG41067TZ transcriptional regulator, MarR family B7470_04135 ENOG4105PFC Transcriptional regulator B7470_04145 ENOG4105E33 succinate dehydrogenase B7470_04155 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit B7470_04165 ENOG4105CFH Aspartokinase B7470_04175 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) B7470_04180 ENOG4105K63 Thioredoxin B7470_04185 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) B7470_04190 ENOG4105C10 Electron transfer flavoprotein B7470_04195 ENOG4105BZJ Electron transfer flavoprotein B7470_04200 ENOG41060WC Enoyl-CoA hydratase B7470_04205 ENOG4107Z3H Transcriptional regulator, TetR family B7470_04210 ENOG4105CEY Amp-dependent synthetase and ligase B7470_04220 ENOG4105C98 muts2 protein B7470_04225 ENOG4105DCG PHP domain protein B7470_04240 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) B7470_04245 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) B7470_04250 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) B7470_04260 ENOG4108RWN rrna methyltransferase B7470_04265 ENOG41067MF small acid-soluble spore protein B7470_04275 ENOG4105CQB FAD linked oxidase domain protein B7470_04280 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) B7470_04295 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) B7470_04300 ENOG4105DRS transport system, permease B7470_04315 ENOG4108MDK Dehydrogenase B7470_04325 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase B7470_04330 ENOG4105EF1 ribulokinase B7470_04345 ENOG4105CN9 Peptidase m42 family protein B7470_04355 ENOG410696E Membrane B7470_04360 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) B7470_04365 ENOG4105VJV 50s ribosomal protein L35 B7470_04370 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) B7470_04380 ENOG41067MG lrgb family B7470_04390 ENOG4105DY9 regulatoR B7470_04395 ENOG4108HRK Histidine kinase B7470_04400 ENOG4105U0R haloacid dehalogenase-like hydrolase B7470_04405 ENOG4105C22 threonyL-tRNA synthetase B7470_04410 ENOG4108TDW sporulation protein YtxC B7470_04430 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) B7470_04435 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) B7470_04440 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase B7470_04445 ENOG4105KVH Transcriptional regulator B7470_04450 ENOG4105F27 Major Facilitator B7470_04455 ENOG4105CV8 reductase B7470_04460 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) B7470_04470 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) B7470_04475 ENOG4105C2M dna polymerase I B7470_04480 ENOG4105BZU Histidine kinase B7470_04485 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B7470_04490 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) B7470_04495 ENOG4108HMX isocitrate dehydrogenase (NADP) B7470_04500 ENOG4105BZN citrate synthase B7470_04510 ENOG4108REF Sporulation integral membrane protein ytvi B7470_04515 ENOG4105FS0 cytoplasmic membrane protein B7470_04520 ENOG4105CA9 Pyruvate kinase B7470_04525 ENOG4105CTQ phosphohexokinase B7470_04535 ENOG4108IEY Carboxyl transferase domain B7470_04540 ENOG4105C6K Malic enzyme B7470_04545 ENOG4105C0B DNA polymerase III (alpha subunit) B7470_04550 ENOG4105VV2 B7470_04560 ENOG4106EVM B7470_04565 ENOG4105SFS phosphoesterase RecJ domain protein B7470_04585 ENOG4105E8R UPF0173 metal-dependent hydrolase B7470_04600 ENOG4105CH7 arginosuccinase B7470_04605 ENOG4105CDH Citrulline--aspartate ligase B7470_04610 ENOG4105EPU Molybdenum cofactor synthesis domain protein B7470_04615 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) B7470_04630 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) B7470_04635 ENOG4105KBJ sporulation protein ytfj B7470_04645 ENOG4105VK3 rdd domain containing protein B7470_04650 ENOG4105D07 Signal peptide peptidase, SppA B7470_04655 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) B7470_04660 ENOG4105EFZ amidohydrolase B7470_04665 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) B7470_04700 ENOG4105U5Y Transcriptional regulator B7470_04710 ENOG4105BZU Histidine kinase B7470_04720 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) B7470_04725 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) B7470_04740 ENOG4105F1V Acetoin utilization protein B7470_04745 ENOG4105W87 Cbs domain B7470_04750 ENOG4105DGU Histone deacetylase B7470_04755 ENOG4105ER2 Ompa motb domain protein B7470_04760 ENOG4107R0U MotA TolQ exbB proton channel B7470_04765 ENOG4105ETE Transcriptional regulator (LacI family B7470_04770 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase B7470_04790 ENOG4105DFU Cell wall formation (By similarity) B7470_04800 ENOG4108VDD TRNA binding domain protein B7470_04815 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ B7470_04830 ENOG4105C6K Malic enzyme B7470_04835 ENOG4105C8F Beta-lactamase domain protein B7470_04840 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) B7470_04850 ENOG4108V15 phosphotransferase enzyme family B7470_04855 ENOG4108IUM Glycogen debranching enzyme B7470_04870 ENOG4107F58 2'-5' rna ligase B7470_04875 ENOG4105C6T cysteine synthase B7470_04880 ENOG4107QSE Dipeptidase B7470_04885 ENOG4105C7N Xanthine uracil vitamin C permease B7470_04900 ENOG4105YW5 deoR family transcriptional regulator B7470_04915 ENOG4105CBX hi0933 family B7470_04920 ENOG4105C94 Transporter B7470_04945 ENOG4105F5H Glycosyl Hydrolase Family 88 B7470_04965 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component B7470_04975 ENOG4106A3M Cytochrome p-450 B7470_04995 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) B7470_05000 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) B7470_05005 ENOG4105NTD Inherit from COG: Hydrolase B7470_05020 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component B7470_05025 ENOG4105I1K ABC transporter B7470_05035 ENOG41085GJ domain protein B7470_05040 ENOG4105C8T Leucyl-tRNA synthetase B7470_05050 ENOG4105BZU Histidine kinase B7470_05055 ENOG410605W Major Facilitator B7470_05060 ENOG4106UBQ B7470_05070 ENOG4105C19 ABC transporter B7470_05075 ENOG4105EWM Histidine kinase B7470_05085 ENOG4107R34 abc transporter permease protein B7470_05090 ENOG4105C19 ABC transporter B7470_05105 ENOG4105DVE abc transporter atp-binding protein B7470_05110 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family B7470_05120 ENOG4105N5T Radical SAM Protein B7470_05135 ENOG4105E8V Alpha Beta Hydrolase Fold protein B7470_05140 ENOG4108Z0R Transferase B7470_05145 ENOG4105C85 amino acid B7470_05150 ENOG4105CAQ asparagine synthetase B7470_05155 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP B7470_05160 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase B7470_05175 ENOG4105D2X ABC transporter substrate-binding protein B7470_05185 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component B7470_05200 ENOG4108RMU ferritin dps family protein B7470_05215 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) B7470_05220 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) B7470_05225 ENOG4108V2W Carbonate dehydratase B7470_05250 ENOG4105CC5 ABC transporter B7470_05255 ENOG4105CC5 ABC transporter B7470_05260 ENOG4105DIK (ABC) transporter B7470_05265 ENOG4105DSE periplasmic solute binding protein B7470_05270 ENOG4105DTQ mandelate racemase muconate lactonizing B7470_05275 ENOG4105CEY Amp-dependent synthetase and ligase B7470_05280 ENOG4108IPT Naphthoate synthase B7470_05285 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) B7470_05290 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) B7470_05295 ENOG4105E4F Isochorismate synthase B7470_05320 ENOG4108IAJ Nad-dependent epimerase dehydratase B7470_05325 ENOG4107SBE Glycosyl transferase (Group 1 B7470_05340 ENOG4107SBE Glycosyl transferase (Group 1 B7470_05345 ENOG4108KS4 Spore coat protein B7470_05360 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) B7470_05370 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) B7470_05500 ENOG4105N67 Proton-coupled thiamine transporter YuaJ B7470_05505 ENOG4105VRR gCN5-related N-acetyltransferase B7470_05510 ENOG4105DZ6 Band 7 protein B7470_05520 ENOG4106DF1 B7470_05525 ENOG4108VNY MOSC domain protein B7470_05530 ENOG4108JB8 alcohol dehydrogenase B7470_05535 ENOG4105C26 Dehydrogenase B7470_05540 ENOG4105TRT Transcriptional regulator B7470_05555 ENOG4105CZN Potassium uptake protein B7470_05560 ENOG4107I77 yiaA/B two helix domain B7470_05565 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj B7470_05585 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) B7470_05595 ENOG4105EE0 oxidoreductase B7470_05600 ENOG4105DKG l-rhamnose isomerase B7470_05605 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) B7470_05610 ENOG4105DET Rhamnulokinase B7470_05615 ENOG4105E98 transcriptional regulator DeoR family B7470_05635 ENOG4105C8Q Methyl-accepting chemotaxis B7470_05645 ENOG4105C8Q Methyl-accepting chemotaxis B7470_05660 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme B7470_05670 ENOG4105C37 (CBS) domain B7470_05685 ENOG4107PBV potassium channel B7470_05690 ENOG4107PBV potassium channel B7470_05705 ENOG4107QYV phosphohexose isomerase B7470_05715 ENOG4107QW4 alcohol dehydrogenase B7470_05720 ENOG4105WG9 Conserved Protein B7470_05730 ENOG4105CHM Aminotransferase B7470_05735 ENOG4108ZB6 transcriptional regulator AsnC family B7470_05740 ENOG4108MUZ hydrolase B7470_05750 ENOG4105C87 Aminotransferase class I and II B7470_05755 ENOG4108HGU Histidine kinase B7470_05760 ENOG4105Y38 Kinase-associated protein B B7470_05780 ENOG4105BZ4 penicillin-binding protein B7470_05785 ENOG4105KIR Thiol-disulfide oxidoreductase dcc B7470_05800 ENOG4108MRH transcriptional regulatory protein B7470_05805 ENOG4105DIH basic membrane B7470_05810 ENOG4108JQ9 ABC transporter B7470_05815 ENOG4105UIB (ABC) transporter B7470_05835 ENOG4105D65 subunit l B7470_05840 ENOG4105HC0 Na H antiporter B7470_05845 ENOG4108ZE9 Monovalent cation H antiporter subunit C B7470_05850 ENOG4108JPZ Monovalent cation H antiporter subunit D B7470_05855 ENOG4105SC1 monovalent cation H antiporter subunit E B7470_05865 ENOG4105KJM monovalent cation h antiporter subunit g B7470_05870 ENOG4105KA0 thioesterase Superfamily protein B7470_05880 ENOG4105BZU Histidine kinase B7470_05905 ENOG4105D58 Diguanylate phosphodiesterase B7470_05910 ENOG4105DAP Nicotinate phosphoribosyltransferase B7470_05935 ENOG4105C02 permease B7470_05955 ENOG410904N short-chain dehydrogenase reductase B7470_05995 ENOG4108K8K Transcriptional regulator B7470_06000 ENOG4105DCF alanine dehydrogenase B7470_06010 ENOG4105WQT MbtH domain protein B7470_06015 ENOG4105CEY Amp-dependent synthetase and ligase B7470_06020 ENOG4105WQI isochorismatase B7470_06025 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase B7470_06030 ENOG4105E4F Isochorismate synthase B7470_06035 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase B7470_06040 ENOG4105NIV Esterase B7470_06060 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) B7470_06070 ENOG41069ER domain protein B7470_06085 ENOG4105CEP NADH dehydrogenase B7470_06090 ENOG4105CAY ferredoxin--nadp reductase B7470_06110 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 B7470_06215 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B7470_06220 ENOG4108YX9 iron--sulfur cluster insertion protein erpA B7470_06235 ENOG4105ZKE UPF0349 protein B7470_06250 ENOG41083MR nifu domain-containing protein B7470_06255 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein B7470_06260 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) B7470_06265 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) B7470_06270 ENOG4105D6E homoserine dehydrogenase B7470_06280 ENOG4108W5N phosphatidylglycerophosphatase a B7470_06285 ENOG4105D4U had-superfamily hydrolase, subfamily iia B7470_06295 ENOG4105MMD transcriptional regulator B7470_06300 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) B7470_06305 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) B7470_06310 ENOG4105FAA peptidase M23 B7470_06315 ENOG4108YTE sporulation protein YunB B7470_06320 ENOG4105KZD Domain of unknown function (DUF1805) B7470_06325 ENOG4107R8B 5'-nucleotidase B7470_06335 ENOG4105I3N Conserved Protein B7470_06345 ENOG4105CD3 dihydroorotase B7470_06350 ENOG4105G9B Transcriptional regulator B7470_06365 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) B7470_06370 ENOG4105VT2 5-hydroxyisourate hydrolase B7470_06380 ENOG4107YV9 domain protein B7470_06385 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding B7470_06400 ENOG4105XRQ Xanthine dehydrogenase accessory factor B7470_06405 ENOG4105C5R Aminotransferase B7470_06415 ENOG4108K8S endonuclease I B7470_06420 ENOG4108IJ9 (ABC) transporter B7470_06425 ENOG4105FDP GntR family transcriptional regulator B7470_06430 ENOG4108KPW sugar kinase B7470_06440 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component B7470_06445 ENOG4105XN3 extracellular solute-binding protein family 1 B7470_06450 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine B7470_06455 ENOG4105PKS Excinuclease abc c subunit domain protein B7470_06460 ENOG4107VFR oxidoreductase B7470_06475 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase B7470_06480 ENOG4105NPE arsR family transcriptional regulator B7470_06485 ENOG4105DIW FeS assembly protein SUFB B7470_06490 ENOG4108UNV SUF system FeS assembly protein, NifU family B7470_06495 ENOG4105C9B Cysteine desulfurase B7470_06500 ENOG4105JRK feS assembly protein SufD B7470_06505 ENOG4105C3K feS assembly ATPase SufC B7470_06525 ENOG4105D01 (LipO)protein B7470_06530 ENOG4108UMI ABC transporter, permease B7470_06535 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) B7470_06560 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) B7470_06565 ENOG41080E8 Transcriptional regulator, Spx MgsR family B7470_06570 ENOG4105C1G acyl-Coa dehydrogenase B7470_06575 ENOG4105CHU acetyl-coa acetyltransferase B7470_06605 ENOG41067TZ transcriptional regulator, MarR family B7470_06610 ENOG4105C0R drug resistance transporter emrb qaca subfamily B7470_06615 ENOG4105MDS 4-oxalocrotonate tautomerase B7470_06625 ENOG4105EGI Transcriptional regulator B7470_06635 ENOG4105E0A ABC, transporter B7470_06705 ENOG4105HUF DNA protection during starvation protein B7470_06710 ENOG4105C0H protease B7470_06720 ENOG4105F3H Histidine kinase B7470_06730 ENOG41067SE Tetr family transcriptional regulator B7470_06735 ENOG4105C9Q fumarate hydratase class II B7470_06760 ENOG4105WH1 Two component transcriptional regulator luxr family B7470_06765 ENOG4105ENE Histidine kinase B7470_06780 ENOG41087YS Phage shock protein A B7470_06795 ENOG4108WBT adenosyltransferase B7470_06800 ENOG4105E0A ABC, transporter B7470_06805 ENOG4105EHG Permease protein B7470_06810 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) B7470_06815 ENOG4105EWI Short-chain dehydrogenase reductase Sdr B7470_06820 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein B7470_06830 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B7470_06850 ENOG4105F0F Oxalate decarboxylase B7470_06860 ENOG4107RBB ABC transporter, permease B7470_06865 ENOG4105C19 ABC transporter B7470_06870 ENOG4108WMK Efflux transporter RND family MFP subunit B7470_06875 ENOG4105E0A ABC, transporter B7470_06880 ENOG4105EHG Permease protein B7470_06885 ENOG4105DQ5 transport system permease protein B7470_06900 ENOG4105D5Q Arginine ornithine antiporter B7470_06915 ENOG4107K5X Membrane-bound metal-dependent hydrolase B7470_06920 ENOG4107QZ2 Sulfatase B7470_06925 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family B7470_06930 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein B7470_06935 ENOG4105E0C molybdate abc transporter B7470_06950 ENOG4105EEQ Na H antiporter B7470_06955 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) B7470_06960 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) B7470_06965 ENOG4105EEM helicase B7470_06975 ENOG4105EN6 Membrane B7470_06985 ENOG4107ZQN disulfide bond B7470_06990 ENOG4105C59 p-type ATPase B7470_06995 ENOG4105C59 p-type ATPase B7470_07000 ENOG410681U heavy metal transport detoxification protein B7470_07005 ENOG4105VPX protein, conserved in bacteria B7470_07010 ENOG4105D9R oxidoreductase B7470_07020 ENOG4105ME7 Membrane B7470_07030 ENOG4105KPY Small multidrug resistance protein B7470_07035 ENOG4105KBX Transcriptional regulator, TetR family B7470_07040 ENOG4105EWI Short-chain dehydrogenase reductase Sdr B7470_07065 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B7470_07085 ENOG41068G1 B7470_07095 ENOG4108S4A n-acetylmuramoyl-l-alanine amidase B7470_07320 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) B7470_07325 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) B7470_07335 ENOG4105XZU Preprotein translocase, subunit SecG B7470_07360 ENOG4105KVH Transcriptional regulator B7470_07365 ENOG4105C8Q Methyl-accepting chemotaxis B7470_07370 ENOG4105R40 Glycine betaine carnitine choline B7470_07375 ENOG4108HQR Glycine betaine B7470_07380 ENOG4105E90 ABC transporter B7470_07385 ENOG4108IJ8 ABC transporter B7470_07390 ENOG4107HG4 Transcriptional regulator B7470_07395 ENOG4105R40 Glycine betaine carnitine choline B7470_07400 ENOG4108HQR Glycine betaine B7470_07405 ENOG4105E90 ABC transporter B7470_07410 ENOG4108IJ8 ABC transporter B7470_07415 ENOG4107HG4 Transcriptional regulator B7470_07420 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein B7470_07425 ENOG4108QCI YvbH-like oligomerisation region B7470_07435 ENOG4105T65 Membrane-associated protein B7470_07440 ENOG4108W0I acetyltransferase B7470_07445 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) B7470_07450 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) B7470_07455 ENOG4105CP7 Triose-phosphate isomerase B7470_07460 ENOG4105BZA Phosphoglycerate kinase B7470_07465 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase B7470_07480 ENOG4105CMD Transcriptional regulator, GntR family B7470_07485 ENOG4105DEN Luciferase family B7470_07495 ENOG4105GZI Transcriptional regulator B7470_07500 ENOG4107RT3 EamA-like transporter family B7470_07515 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) B7470_07520 ENOG4107QR9 Iron-sulfur cluster binding protein B7470_07525 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) B7470_07535 ENOG4105BZU Histidine kinase B7470_07540 ENOG4105KCT ABC transporter B7470_07545 ENOG4108M15 ABC transporter B7470_07565 ENOG4107R6F Alpha Beta Hydrolase Fold protein B7470_07570 ENOG4108MJI response regulator B7470_07585 ENOG4105EG2 ABC transporter, permease B7470_07595 ENOG4107FKK extracellular solute-binding protein family 1 B7470_07605 ENOG4105JXH GntR family transcriptional regulator B7470_07610 ENOG4105DAA L-lactate B7470_07615 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B7470_07625 ENOG4108ZPC Polysaccharide pyruvyl transferase B7470_07630 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase B7470_07635 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family B7470_07640 ENOG4105D3Q Sugar transferase B7470_07650 ENOG4105K64 Glycosyl transferase, family 2 B7470_07660 ENOG4107QRS glycosyltransferase group 2 family protein B7470_07665 ENOG41068W6 Capsular polysaccharide biosynthesis protein B7470_07670 ENOG4108KMV Glycosyl transferase (Group 1 B7470_07675 ENOG4105K64 Glycosyl transferase, family 2 B7470_07680 ENOG4108PQP glycosyl transferase group 1 B7470_07690 ENOG4108QV3 biosynthesis protein B7470_07695 ENOG4105HTX biosynthesis protein B7470_07705 ENOG4105EBR Carboxylesterase B7470_07715 ENOG4105PY6 Phenolic acid decarboxylase B7470_07720 ENOG4105NI3 Protein of unknown function (DUF3237) B7470_07725 ENOG4105NI3 Protein of unknown function (DUF3237) B7470_07740 ENOG4105EDQ levansucrase EC 2.4.1.10 B7470_07745 ENOG4108HKT sucrose-6-phosphate hydrolase B7470_07750 ENOG4107QTZ amino acid B7470_07785 ENOG4105EC2 ftsk spoIIIe B7470_07805 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase B7470_07840 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj B7470_08020 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B7470_08030 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) B7470_08035 ENOG4107URF beta-phospho-glucomutase B7470_08040 ENOG4105CG3 alpha amylase, catalytic region B7470_08055 ENOG4105EG2 ABC transporter, permease B7470_08060 ENOG4105D56 permease protein B7470_08065 ENOG4107FKK extracellular solute-binding protein family 1 B7470_08070 ENOG4108IUK alpha amylase, catalytic B7470_08075 ENOG4105FKQ transcriptional regulator B7470_08080 ENOG4108URH decarboxylase B7470_08090 ENOG4105CHH sulfate transporter B7470_08095 ENOG4108V2W Carbonate dehydratase B7470_08100 ENOG4105C5I Dehydrogenase B7470_08110 ENOG4105C19 ABC transporter B7470_08115 ENOG4105EWM Histidine kinase B7470_08130 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase B7470_08135 ENOG4105KRI phosphocarrier protein (HPr B7470_08140 ENOG4105CIE May be required for sporulation (By similarity) B7470_08145 ENOG4105CHW UPF0052 protein B7470_08150 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) B7470_08155 ENOG4108Z4K mutator MutT protein B7470_08160 ENOG4105C3M thioredoxin reductase B7470_08175 ENOG4105BZ1 (ABC) transporter B7470_08185 ENOG4106FGC B7470_08195 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase B7470_08200 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) B7470_08205 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase B7470_08210 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) B7470_08215 ENOG4105ECC imidazole-glycerol-phosphate dehydratase B7470_08220 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) B7470_08225 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) B7470_08230 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) B7470_08240 ENOG4108E16 pectate lyase B7470_08255 ENOG4107XGZ Hydrolase B7470_08260 ENOG4105HKU nucleoside recognition domain-containing protein B7470_08265 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) B7470_08270 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) B7470_08275 ENOG4105CE4 GlcNAc 6-P deacetylase B7470_08280 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) B7470_08285 ENOG4105FDP GntR family transcriptional regulator B7470_08290 ENOG41088CQ domain protein B7470_08305 ENOG41086DT Membrane protein of unknown function B7470_08310 ENOG41067S9 phage shock protein C, PspC B7470_08315 ENOG4108PY7 B7470_08330 ENOG4105I03 Flagellin B7470_08335 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) B7470_08340 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) B7470_08355 ENOG4105MKU Transcriptional regulator B7470_08375 ENOG4105CN1 protease B7470_08380 ENOG4105CRP Part of the ABC transporter FtsEX involved in B7470_08385 ENOG4105CAK Cell division ATP-binding protein ftsE B7470_08410 ENOG4105MS2 ribosomal subunit Interface protein B7470_08425 ENOG4105MQ3 flagellar protein FliS B7470_08430 ENOG4107RT6 flagellar hook-associated B7470_08435 ENOG41083S7 flagellar protein FlaG B7470_08440 ENOG4105I03 Flagellin B7470_08445 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) B7470_08450 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) B7470_08455 ENOG4105MKD B7470_08460 ENOG4105DTJ flagellar hook-associated protein B7470_08465 ENOG4105E1Q flagellar hook-associated protein B7470_08480 ENOG4105RU3 B7470_08485 ENOG41081UC Inherit from COG: Competence protein B7470_08505 ENOG4105WH1 Two component transcriptional regulator luxr family B7470_08510 ENOG4105BZU Histidine kinase B7470_08515 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein B7470_08520 ENOG4108KGH TRANSCRIPTIONal B7470_08555 ENOG4108RDQ ABC transporter B7470_08565 ENOG4105ESV Glycosyl transferase, family 4 B7470_08570 ENOG4107EF8 Glycosyl transferase (Group 1 B7470_08585 ENOG4105QZI O-Antigen Polymerase B7470_08595 ENOG4105C6Y Udp-glucose 6-dehydrogenase B7470_08600 ENOG4107RA4 Glycosyl transferase (Group 1 B7470_08605 ENOG4105PSV Polysaccharide Biosynthesis Protein B7470_08610 ENOG4105D3Q Sugar transferase B7470_08620 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase B7470_08625 ENOG4105JFG SpoIID LytB domain protein B7470_08655 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase B7470_08660 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase B7470_08670 ENOG4105EY8 ABC transporter B7470_08690 ENOG4107SJB teichoic acid biosynthesis B7470_08695 ENOG4107SJB teichoic acid biosynthesis B7470_08700 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase B7470_08710 ENOG4107RZX Teichoic acid biosynthesis protein B7470_08720 ENOG4105DG6 mannose-6-phosphate isomerase B7470_08735 ENOG4108NHD germination protein B7470_08745 ENOG4108KGH TRANSCRIPTIONal B7470_08750 ENOG4105J7I hydrolase B7470_08755 ENOG4105K4H Nlp p60 protein B7470_08765 ENOG4105PNM synthesis protein B7470_08775 ENOG4105N98 Capsule biosynthesis protein capB B7470_08785 ENOG4105ETE Transcriptional regulator (LacI family B7470_08790 ENOG4108RVA ribokinase B7470_08795 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) B7470_08800 ENOG4105C2J ABC transporter B7470_08805 ENOG4105CNN ABC, transporter B7470_08810 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator B7470_08825 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein B7470_08830 ENOG4107FQX Alpha-acetolactate decarboxylase B7470_08840 ENOG4107RSM transcriptional regulator B7470_08855 ENOG4106UIA B7470_08870 ENOG4107XC4 flavin reductase domain protein, FMN-binding B7470_08880 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) B7470_08890 ENOG4105CAH Chromate B7470_08895 ENOG4105FGV Chromate B7470_08905 ENOG4108WS4 fmn reductase B7470_08910 ENOG4107V2S Transcriptional regulator B7470_08960 ENOG4105C6Y Udp-glucose 6-dehydrogenase B7470_08965 ENOG4108RB3 Capsular polysaccharide biosynthesis protein B7470_08970 ENOG4107YJ4 chain length determinant protein B7470_08975 ENOG4105HTX biosynthesis protein B7470_08985 ENOG4105KBK Zinc finger, swim domain protein B7470_08990 ENOG4105C0D helicase B7470_09000 ENOG410667J hydrolase B7470_09005 ENOG4105E98 transcriptional regulator DeoR family B7470_09010 ENOG4105Z8H single-stranded DNA-binding protein B7470_09035 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) B7470_09040 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) B7470_09050 ENOG4105CGA flagellar basal-body rod protein FlgG B7470_09060 ENOG4105DFF Rod shape-determining protein mreb B7470_09065 ENOG4105MT0 Sporulation transcriptional regulator spoiiid B7470_09075 ENOG4107MII Sugar-specific transcriptional regulator TrmB B7470_09080 ENOG4105CZM Major Facilitator B7470_09085 ENOG4108M26 parallel beta-helix repeat protein B7470_09090 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease B7470_09095 ENOG41080V3 Major Facilitator superfamily B7470_09100 ENOG4105D3W isochorismatase B7470_09105 ENOG4107P26 B7470_09110 ENOG4105BZU Histidine kinase B7470_09120 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase B7470_09130 ENOG4105FRN stage II sporulation protein B7470_09135 ENOG4107TCE N-acetyltransferase B7470_09155 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) B7470_09160 ENOG4107TXC Transcriptional regulator B7470_09165 ENOG4106BRK B7470_09170 ENOG4108RYK Nad-dependent epimerase dehydratase B7470_09175 ENOG4108Z40 Transcriptional regulator B7470_09180 ENOG4105CQM Urea amidohydrolase subunit alpha B7470_09185 ENOG4105KI2 Urea amidohydrolase subunit beta B7470_09190 ENOG4108YZ9 Urea amidohydrolase subunit gamma B7470_09230 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) B7470_09240 ENOG4108TF4 von Willebrand factor, type A B7470_09255 ENOG4105JFG SpoIID LytB domain protein B7470_09260 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) B7470_09270 ENOG4106778 Protein of unknown function (DUF1146) B7470_09280 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) B7470_09285 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) B7470_09290 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) B7470_09295 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) B7470_09315 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) B7470_09325 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) B7470_09330 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) B7470_09335 ENOG4108UIC UPF0340 protein B7470_09340 ENOG4108YZG isomerase B7470_09345 ENOG4107WAU Protein tyrosine phosphatase B7470_09350 ENOG410815N Probably functions as a manganese efflux pump (By similarity) B7470_09355 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) B7470_09365 ENOG4108ZXQ stage ii sporulation protein r B7470_09380 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) B7470_09385 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) B7470_09390 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase B7470_09400 ENOG4107TT2 Auxin Efflux Carrier B7470_09405 ENOG4105C6K Malic enzyme B7470_09410 ENOG4107104 thymidine kinase B7470_09415 ENOG41082DI 50s ribosomal protein l31 B7470_09420 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) B7470_09425 ENOG4105CBT Fructose-1,6-bisphosphatase B7470_09430 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) B7470_09435 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway B7470_09440 ENOG4105D2N Aldolase B7470_09445 ENOG410812K response regulator receiver protein B7470_09455 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) B7470_09465 ENOG4105C1G acyl-Coa dehydrogenase B7470_09470 ENOG4105DF6 Fe-S oxidoreductase B7470_09480 ENOG4105E5J UV damage endonuclease B7470_09490 ENOG4105NAE bifunctional deaminase-reductase domain protein B7470_09500 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) B7470_09515 ENOG4105R3A Nitrate reductase B7470_09520 ENOG4108IUE nitrate reductase beta subunit B7470_09540 ENOG4107V6Q Cyclic nucleotide-binding domain B7470_09550 ENOG4105C75 arginyL-tRNA synthetase B7470_09555 ENOG410684U Domain of unknown function (DUF1934) B7470_09570 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E B7470_09620 ENOG4107JM4 Tetratricopeptide repeat B7470_09635 ENOG4105CYW agmatinase B7470_09640 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) B7470_09645 ENOG4105BZ4 penicillin-binding protein B7470_09655 ENOG4108XFG YwhD family B7470_09660 ENOG4108Z4T Peptidase M50 B7470_09665 ENOG41069HH 4-oxalocrotonate tautomerase B7470_09670 ENOG41067TZ transcriptional regulator, MarR family B7470_09675 ENOG4105C22 threonyL-tRNA synthetase B7470_09680 ENOG4105C57 major facilitator superfamily B7470_09685 ENOG41062ES Transcriptional regulator B7470_09695 ENOG4105DCI Phosphohydrolase B7470_09705 ENOG4108VCI transcription factor, rsfa family B7470_09710 ENOG4108RNG Permease of the drug metabolite transporter B7470_09715 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) B7470_09720 ENOG4105DUM transcriptional regulator, lysR family B7470_09725 ENOG4108IJ2 phosphate acetyltransferase B7470_09740 ENOG4105CHM Aminotransferase B7470_09750 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase B7470_09755 ENOG4105CHR reductase B7470_09760 ENOG4106CHD Bacilysin biosynthesis protein bacB B7470_09765 ENOG41061WN bacilysin biosynthesis protein B7470_09770 ENOG4105FCW Major Facilitator superfamily B7470_09785 ENOG4105C26 Dehydrogenase B7470_09790 ENOG4105D82 Glutamate dehydrogenase B7470_09800 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase B7470_09805 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase B7470_09810 ENOG4105C1B dTDP-glucose 4-6-dehydratase B7470_09815 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) B7470_09820 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG B7470_09825 ENOG4107TY6 Acylneuraminate cytidylyltransferase B7470_09835 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD B7470_09840 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase B7470_09880 ENOG4105C26 Dehydrogenase B7470_09885 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) B7470_09890 ENOG4108RJ9 Glycosyl transferase, family 2 B7470_09895 ENOG4105DWF phosphomethylpyrimidine kinase B7470_09910 ENOG4105C5Y PTS System B7470_09915 ENOG4108QTI )-transporter B7470_09930 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin B7470_09935 ENOG4105DEN Luciferase family B7470_09940 ENOG4108DBC nitroreductase B7470_09960 ENOG41060D1 Quinol oxidase B7470_09965 ENOG4105CCU oxidase (Subunit III) B7470_09970 ENOG4105BZ9 Cytochrome C oxidase, subunit I B7470_09975 ENOG4105E2S oxidase) subunit II B7470_09980 ENOG4107BMA Transglycosylase associated protein B7470_09990 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) B7470_09995 ENOG4105WH5 Teichoic acid glycosylation protein B7470_10020 ENOG4107ZXU DSBA oxidoreductase B7470_10025 ENOG4105DBE peroxidase B7470_10030 ENOG410650H (LipO)protein B7470_10035 ENOG4107SJW iron permease, FTR1 B7470_10040 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) B7470_10050 ENOG4105CMU LysR family (Transcriptional regulator B7470_10055 ENOG4105VAW lrga family B7470_10060 ENOG41067MG lrgb family B7470_10065 ENOG4105D8G Major Facilitator superfamily B7470_10085 ENOG4108YV3 Protein of unknown function (DUF2711) B7470_10090 ENOG4105CK1 PTS System B7470_10110 ENOG4105X1N Glycosyl transferase family 8 B7470_10120 ENOG4105GVJ transcriptional regulator B7470_10125 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) B7470_10130 ENOG4105IIU Aminopeptidase B7470_10145 ENOG4105DQ6 Transposase B7470_10150 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase B7470_10165 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) B7470_10170 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein B7470_10180 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD B7470_10190 ENOG4105CM2 brancheD-chain amino acid aminotransferase B7470_10195 ENOG4105F8D glycoside hydrolase family 4 B7470_10200 ENOG4105VCP PTS System B7470_10205 ENOG4105CK1 PTS System B7470_10210 ENOG4105VZJ PTS System B7470_10215 ENOG4105EMD TRANSCRIPTIONal B7470_10225 ENOG4108VX5 3-methyladenine DNA glycosylase B7470_10230 ENOG4105CH6 catalase B7470_10245 ENOG4105DA5 (ABC) transporter B7470_10250 ENOG41069JR B7470_10270 ENOG4105ETS cytosine purines uracil thiamine allantoin B7470_10275 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) B7470_10280 ENOG4108JJ8 (ABC) transporter B7470_10285 ENOG4108JJ9 ABC, transporter B7470_10290 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii B7470_10295 ENOG4105C4M (Ubiquinol oxidase) subunit I B7470_10300 ENOG4105D2K citrate carrier protein B7470_10315 ENOG4107BJW polysaccharide deacetylase B7470_10335 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) B7470_10345 ENOG4105CMR udp-glucose 4-epimerase B7470_10355 ENOG4105BZU Histidine kinase B7470_10360 ENOG4105WH1 Two component transcriptional regulator luxr family B7470_10365 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) B7470_10390 ENOG4105DTD Dehydrogenase B7470_10395 ENOG4108IIH CoA-transferase subunit B B7470_10400 ENOG4105D6N CoA-transferase, subunit a B7470_10405 ENOG4105CY2 Citrate transporter B7470_10410 ENOG4105DHI Methyltransferase B7470_10430 ENOG4105CH6 catalase B7470_10435 ENOG4105D4T Citrate transporter B7470_10440 ENOG4108RZ2 Glycoside hydrolase family 16 B7470_10445 ENOG4105CID antiterminator B7470_10460 ENOG4105DEU major facilitator superfamily B7470_10465 ENOG4105C1J atp-dependent rna helicase B7470_10470 ENOG4107TDE lipolytic protein G-D-S-L family B7470_10600 ENOG4107YZX Universal stress protein B7470_10610 ENOG4105C5Y PTS System B7470_10620 ENOG4107EV6 Inherit from COG: YD repeat protein B7470_10630 ENOG4107EV6 Inherit from COG: YD repeat protein B7470_10645 ENOG4108F3G Type I restriction-modification system, R subunit B7470_10650 ENOG4105M6F mutator MutT protein B7470_10660 ENOG4106Z5D Glycoside Hydrolase Family 43 B7470_10665 ENOG4105CGP Urocanate hydratase B7470_10675 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) B7470_10680 ENOG4105D9N nucleoside B7470_10690 ENOG4107RHR regulatoR B7470_10695 ENOG4108TM9 integral membrane protein B7470_10700 ENOG4105ENY Ethanolamine utilization protein eutH B7470_10705 ENOG4108PGP mmge prpd family protein B7470_10710 ENOG4105CH2 amidohydrolase B7470_10720 ENOG4108HW4 amino acid AbC transporter B7470_10725 ENOG4105EAB amino acid AbC transporter B7470_10730 ENOG4108XSB acetyltransferase, (GNAT) family B7470_10735 ENOG4105CPU Monooxygenase B7470_10740 ENOG4107QHE Choloylglycine hydrolase B7470_10745 ENOG410667J hydrolase B7470_10775 ENOG4108V5C ABC transporter B7470_10805 ENOG4105D2N Aldolase B7470_10810 ENOG4107TRN Xylose isomerase domain protein TIM barrel B7470_10815 ENOG4105F0H myo-inositol catabolism protein B7470_10820 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) B7470_10830 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) B7470_10835 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) B7470_10840 ENOG4105D7K pfkb domain protein B7470_10865 ENOG4105CPC Aldo Keto reductase B7470_10895 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) B7470_10960 ENOG4105J7D transcriptional regulator B7470_10965 ENOG4107JEE Short-chain dehydrogenase reductase Sdr B7470_10970 ENOG41061AU MarR family Transcriptional regulator B7470_10980 ENOG41067MG lrgb family B7470_10990 ENOG4105BZW Glycerate kinase B7470_10995 ENOG4105G3Z GntR family transcriptional regulator B7470_11000 ENOG4105CMG Carbohydrate kinase B7470_11005 ENOG4105C6Z Gluconate B7470_11010 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) B7470_11015 ENOG4105D3R alkyl hydroperoxide reductase B7470_11020 ENOG4108JU3 Alkyl hydroperoxide reductase B7470_11025 ENOG4105CS2 ec 3.2.1.21 B7470_11040 ENOG4108S3Y transcriptional regulator B7470_11045 ENOG4106KKU B7470_11050 ENOG4108Z15 abc transporter atp-binding protein B7470_11055 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 B7470_11070 ENOG4105VN1 Heat shock protein B7470_11080 ENOG4108VKI Cell wall hydrolase B7470_11085 ENOG4105EN2 IstB domain-containing protein ATP-binding protein B7470_11090 ENOG4106QJ6 Integrase catalytic subunit B7470_11105 ENOG4105ENA helicase B7470_11170 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) B7470_11185 ENOG4105E2A Dehydrogenase B7470_11205 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) B7470_11210 ENOG4105WQG acetyltransferase B7470_11215 ENOG410780I phosphoprotein phosphatase activity B7470_11225 ENOG41066UZ arginase EC 3.5.3.1 B7470_11230 ENOG4108IQI permease B7470_11235 ENOG4105C8Y Acetylornithine aminotransferase B7470_11260 ENOG41082BM Transcriptional regulator, arsr family B7470_11265 ENOG4108JUB Transcriptional regulator B7470_11270 ENOG4105BZU Histidine kinase B7470_11275 ENOG4105C0H protease B7470_11280 ENOG4105Q2H domain protein B7470_11295 ENOG4105BZU Histidine kinase B7470_11300 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7470_11325 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis B7470_11330 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase B7470_11335 ENOG4105CDU Replicative dna helicase B7470_11355 ENOG4105DJ2 Major Facilitator Superfamily B7470_11360 ENOG4105EDW glycosyl transferase, family 39 B7470_11365 ENOG4105K9Q Binds to the 23S rRNA (By similarity) B7470_11370 ENOG4105BZR domain protein B7470_11375 ENOG4108XMW Membrane B7470_11390 ENOG4105KVH Transcriptional regulator B7470_11395 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase B7470_11415 ENOG41090E6 transcriptional regulator MERR family B7470_11425 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein B7470_11430 ENOG4105DDN Pentapeptide repeat-containing protein B7470_11445 ENOG4108U05 Transcriptional regulator B7470_11450 ENOG41082BV acetyltransferase B7470_11460 ENOG4108U7W acetyltransferase B7470_11465 ENOG4105UNS Pfam:DUF419 B7470_11470 ENOG4105NAE bifunctional deaminase-reductase domain protein B7470_11475 ENOG4105C7Z Conserved Protein B7470_11480 ENOG4105FTQ Dna gyrase B7470_11485 ENOG4105C7Z Conserved Protein B7470_11490 ENOG4107FCW Abortive infection protein B7470_11500 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase B7470_11505 ENOG4105D06 uba thif-type nad fad binding protein B7470_11510 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit B7470_11525 ENOG4105CGK Exodeoxyribonuclease III B7470_11530 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) B7470_11535 ENOG4108UUM single-stranded DNA-binding protein B7470_11540 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) B7470_11545 ENOG4105C3G gtp-binding protein B7470_11550 ENOG4108J2R molybdopterin oxidoreductase B7470_11555 ENOG4105VDK protein, conserved in bacteria B7470_11565 ENOG4108ZDA Sporulation protein YyaC B7470_11570 ENOG4105FA0 parb-like partition protein B7470_11575 ENOG4107QJE Chromosome Partitioning Protein B7470_11590 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) B7470_11595 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) B7470_11600 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) B7470_11615 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) B7470_11625 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) B7470_11630 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) B7470_11635 ENOG410848D S4 domain protein YaaA B7470_11650 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) B7470_11655 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) B7470_11690 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) B7470_11700 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) B7470_11705 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) B7470_11710 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) B7470_11720 ENOG4105ZMH deoxynucleoside kinase B7470_11730 ENOG4105VRS hydrolase family 18 B7470_11735 ENOG4105GTG Isochorismatase B7470_11740 ENOG4108Z6B deaminase B7470_11750 ENOG4105C6E dna polymerase iii B7470_11755 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) B7470_11760 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) B7470_11770 ENOG41067KS pro-sigma K processing B7470_11810 ENOG4105CDW Resistance protein B7470_11815 ENOG4105CXN decarboxylase B7470_11820 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) B7470_11825 ENOG4105X0R protein from nitrogen regulatory protein P-II B7470_11830 ENOG4105XVJ Protein of unknown function (DUF327) B7470_11835 ENOG4105FA2 dna polymerase iii B7470_11840 ENOG4105MA4 psp1 domain protein B7470_11845 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) B7470_11850 ENOG41060K3 Methyltransferase B7470_11855 ENOG4105VC4 domain protein B7470_11860 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) B7470_11865 ENOG4105KRN Transcriptional regulator, abrb family B7470_11870 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) B7470_11875 ENOG4105F8V Hydrolase, tatD family B7470_11880 ENOG41069ER domain protein B7470_11890 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) B7470_11895 ENOG4105XFA sporulation peptidase YabG B7470_11900 ENOG4105W42 Veg protein B7470_11905 ENOG4105XEW small acid-soluble spore protein B7470_11910 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) B7470_11915 ENOG4105DFT pur operon repressor B7470_11920 ENOG4105KME endoribonuclease L-psp B7470_11925 ENOG4105K4W Could be involved in septation (By similarity) B7470_11930 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) B7470_11935 ENOG4105C5T Phosphoribosyl pyrophosphate synthase B7470_11940 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) B7470_11945 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) B7470_11955 ENOG4108JA2 transcriptioN-repair coupling factor B7470_11960 ENOG4108M14 stage v sporulation protein t B7470_11970 ENOG4108IY2 MazG family B7470_11975 ENOG41082I2 s4 domain protein B7470_11980 ENOG4105VYY sporulation protein yabp B7470_11995 ENOG41060GV RNA binding s1 domain protein B7470_12025 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) B7470_12030 ENOG4108UGV hypoxanthine phosphoribosyltransferase B7470_12035 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) B7470_12045 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) B7470_12050 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase B7470_12055 ENOG4105C6T cysteine synthase B7470_12060 ENOG4105CRQ synthase (Component I) B7470_12065 ENOG4105DDQ anthranilate synthase B7470_12070 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 B7470_12075 ENOG4105EEI dihydropteroate synthase B7470_12080 ENOG4105KRF dihydroneopterin aldolase B7470_12085 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase B7470_12095 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) B7470_12100 ENOG4105CRK lysyL-tRNA synthetase B7470_12185 ENOG4108Z0C Uvrb UvrC protein B7470_12190 ENOG41066A3 ATP guanido phosphotransferase B7470_12200 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) B7470_12205 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) B7470_12210 ENOG4105CTP PilT protein domain protein B7470_12215 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) B7470_12220 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) B7470_12225 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) B7470_12235 ENOG4105D7W serine acetyltransferase B7470_12240 ENOG4105C8N cysteinyl-tRNA synthetase B7470_12245 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) B7470_12250 ENOG4105C2N RNA methyltransferase TrmH family group 3 B7470_12255 ENOG4105M0M Tetracycline resistance protein B7470_12275 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) B7470_12280 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) B7470_12290 ENOG4108VZM 50s ribosomal protein L10 B7470_12295 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) B7470_12300 ENOG4107Y49 methyltransferase B7470_12305 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) B7470_12310 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) B7470_12315 ENOG4105XPM ribosomal protein B7470_12320 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) B7470_12325 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) B7470_12330 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) B7470_12335 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) B7470_12340 ENOG4107SKW Inherit from COG: Alpha beta hydrolase B7470_12345 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) B7470_12350 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) B7470_12355 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) B7470_12360 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) B7470_12365 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity B7470_12370 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) B7470_12375 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) B7470_12385 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) B7470_12390 ENOG41082SA 50s ribosomal protein l29 B7470_12395 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal B7470_12400 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) B7470_12410 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits B7470_12420 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) B7470_12425 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) B7470_12430 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) B7470_12435 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) B7470_12440 ENOG4105VPB 50S ribosomal protein L30 B7470_12445 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) B7470_12450 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) B7470_12460 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) B7470_12470 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) B7470_12480 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits B7470_12485 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) B7470_12490 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) B7470_12495 ENOG4108ZT0 50S ribosomal protein l17 B7470_12500 ENOG4108JJB ABC transporter B7470_12505 ENOG4108JJB ABC transporter B7470_12510 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) B7470_12515 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) B7470_12520 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) B7470_12525 ENOG4108UJD 30S ribosomal protein S9 B7470_12535 ENOG4108I0C methyltransferase B7470_12550 ENOG4105D1F ATP-binding protein B7470_12565 ENOG4108NMV polysaccharide deacetylase B7470_12645 ENOG4105CHH sulfate transporter B7470_12655 ENOG4108SA1 esterase B7470_12675 ENOG410874W AraC family transcriptional regulator B7470_12680 ENOG4105EHZ conserved protein UCP016719 B7470_12685 ENOG4105D17 glycoside hydrolase, family 3 domain protein B7470_12705 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate B7470_12715 ENOG4105EWC Purine nucleoside phosphorylase B7470_12745 ENOG4105EMN RNA polymerase sigma factor B7470_12755 ENOG4105C8B TIGR00159 family B7470_12760 ENOG4107U5W ybbr family B7470_12765 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) B7470_12775 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) B7470_12790 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) B7470_12795 ENOG4108TWJ NADH dehydrogenase subunit 5 B7470_12815 ENOG4105GPN Uncharacterized conserved protein (DUF2294) B7470_12835 ENOG4105G0J serine threonine protein kinase B7470_12845 ENOG4106K80 B7470_12855 ENOG4106DDH Sporulation-specific SASP protein B7470_12865 ENOG4108HWY Beta-lactamase B7470_12870 ENOG4107E6A Cytochrome p-450 B7470_12880 ENOG4107QTZ amino acid B7470_12885 ENOG4107VXM glycerophosphoryl diester phosphodiesterase B7470_12890 ENOG4105CXY transporter B7470_12905 ENOG410645S MarR family Transcriptional regulator B7470_12930 ENOG410631K Membrane B7470_12935 ENOG4106AXJ AraC family transcriptional regulator B7470_12955 ENOG4105GIG B7470_12960 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR B7470_12965 ENOG4108TCS Glutamyl endopeptidase B7470_12975 ENOG4108WC5 Alpha Beta Hydrolase Fold protein B7470_12980 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase B7470_12985 ENOG4107ZTW SNARE associated Golgi B7470_13010 ENOG4105C72 UPF0176 protein B7470_13020 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane B7470_13025 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) B7470_13030 ENOG4108X79 transcriptional regulator B7470_13040 ENOG4105CM2 brancheD-chain amino acid aminotransferase B7470_13045 ENOG4108IQI permease B7470_13050 ENOG4108J5H Homocysteine s-methyltransferase B7470_13065 ENOG4105CSV Glutaminase B7470_13085 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase B7470_13090 ENOG4105C26 Dehydrogenase B7470_13095 ENOG4105DJB Major Facilitator Superfamily B7470_13100 ENOG4105EQX glucarate dehydratase B7470_13105 ENOG41073TP transcriptional regulator B7470_13110 ENOG4105CTX dehydratase B7470_13125 ENOG4106UX7 integral membrane protein B7470_13130 ENOG4105DPZ Two component transcriptional regulator (Winged helix family B7470_13160 ENOG4105MUA Resistance protein B7470_13170 ENOG4105DGI Alkaline phosphatase B7470_13175 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) B7470_13180 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) B7470_13185 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) B7470_13190 ENOG4107EPV Aminotransferase class V B7470_13195 ENOG4105C0R drug resistance transporter emrb qaca subfamily B7470_13200 ENOG4105J7D transcriptional regulator B7470_13205 ENOG4107RB3 L-asparaginase B7470_13210 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold B7470_13220 ENOG41060AI SEC-C motif B7470_13230 ENOG4107Y7X LytTR B7470_13240 ENOG4108SDH ABC, transporter B7470_13245 ENOG4107SET aldo keto reductase B7470_13280 ENOG4105H9W Short-chain dehydrogenase reductase Sdr B7470_13290 ENOG4105DSE periplasmic solute binding protein B7470_13295 ENOG4105DIK (ABC) transporter B7470_13310 ENOG4108N0M stress protein B7470_13315 ENOG4106FN3 tellurium resistance protein B7470_13320 ENOG4106FN3 tellurium resistance protein B7470_13325 ENOG4107TS3 membrane protein, TerC B7470_13330 ENOG4108TTB tellurium resistance protein B7470_13345 ENOG41079KZ Major Facilitator Superfamily B7470_13350 ENOG4107XZQ multidrug resistance protein B7470_13355 ENOG4108A65 Transcriptional regulator B7470_13360 ENOG4108IJ7 Glycine betaine B7470_13365 ENOG4107SQ8 Glycine betaine B7470_13395 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) B7470_13425 ENOG4107RA1 nh(3)-dependent nad( ) synthetase B7470_13430 ENOG4105I1F Resistance protein B7470_13440 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) B7470_13455 ENOG41089UC methyltransferase, type 11 B7470_13460 ENOG4105C5Q Transcriptional regulator B7470_13465 ENOG4105I82 acetyl xylan esterase B7470_13470 ENOG410756H nucleotidyltransferase B7470_13480 ENOG4105C26 Dehydrogenase B7470_13485 ENOG4105CK7 Sodium proline symporter B7470_13490 ENOG4107YHD transcriptional regulator B7470_13500 ENOG4108PJD permease B7470_13505 ENOG4105U6C Alpha beta hydrolase fold protein B7470_13515 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) B7470_13520 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit B7470_13525 ENOG4108IFG nitrite reductase, (NAD(P)H) B7470_13530 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) B7470_13550 ENOG4105S7A ErfK ybiS ycfS ynhG family protein B7470_13565 ENOG4105E5Q amino acid AbC transporter B7470_13570 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein B7470_13580 ENOG4105HHM rdd domain containing protein B7470_13590 ENOG4105K56 Transcriptional regulator B7470_13605 ENOG4105CS2 ec 3.2.1.21 B7470_13625 ENOG41080HJ 6-phospho 3-hexuloisomerase B7470_13630 ENOG4108VA3 3-hexulose-6-phosphate synthase B7470_13635 ENOG4105KVH Transcriptional regulator B7470_13640 ENOG4105CEY Amp-dependent synthetase and ligase B7470_13670 ENOG4105SX7 Transporter B7470_13680 ENOG4105W8Z 4'-phosphopantetheinyl transferase B7470_13695 ENOG4105CDA abc transporter atp-binding protein B7470_13700 ENOG4105DRP amino acid AbC transporter B7470_13710 ENOG4106P55 Transcriptional regulator B7470_13715 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase B7470_13720 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) B7470_13725 ENOG41069ZX B7470_13740 ENOG4105DUX Transporter B7470_13755 ENOG4105E1K spore germination protein B7470_13775 ENOG4107WD8 ABC transporter, permease B7470_13780 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7470_13785 ENOG4105BZU Histidine kinase B7470_13810 ENOG4105CFH Aspartokinase B7470_13815 ENOG4105DHS permease protein B7470_13820 ENOG4105CM4 permease protein B7470_13825 ENOG4108IPW abc transporter atp-binding protein B7470_13845 ENOG4105R8C Transcriptional regulator B7470_13850 ENOG4108DBC nitroreductase B7470_13855 ENOG41067V3 Antibiotic biosynthesis monooxygenase B7470_13860 ENOG4105YVS arsR family transcriptional regulator B7470_13870 ENOG4108JPW Aminotransferase B7470_13875 ENOG4105C26 Dehydrogenase B7470_13885 ENOG4105H9W Short-chain dehydrogenase reductase Sdr B7470_13890 ENOG4105KTB nuclear export factor GLE1 B7470_13895 ENOG4108T5E Copper resistance protein B7470_13900 ENOG4108ZYE Transcriptional regulator B7470_13925 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) B7470_13930 ENOG4108ZX0 Signal peptidase I B7470_13955 ENOG4105E7W lamb ycsf family protein B7470_13960 ENOG4105C5A transporter B7470_13965 ENOG4105CFM UPF0317 protein B7470_13970 ENOG4105P4J Allophanate hydrolase, subunit 1 B7470_13980 ENOG4107258 Transcriptional regulator B7470_13985 ENOG4105XJB lipolytic protein G-D-S-L family B7470_13995 ENOG41061CK Antibiotic biosynthesis monooxygenase B7470_14000 ENOG4107RVG penicillin-binding protein B7470_14005 ENOG4107QM2 Aldo Keto reductase B7470_14010 ENOG4105ETD TRANSCRIPTIONal B7470_14020 ENOG4105HMZ Methyltransferase B7470_14025 ENOG4105CYX Short-chain dehydrogenase reductase Sdr B7470_14040 ENOG410606W general stress protein B7470_14050 ENOG4105VCH membrane B7470_14060 ENOG4105C9U ATP-dependent DNA helicase RecQ B7470_14100 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) B7470_14110 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) B7470_14115 ENOG4105EU9 B7470_14120 ENOG4105QVS general stress protein B7470_14125 ENOG41082W1 Cupin 2, conserved barrel domain protein B7470_14140 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit B7470_14145 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism B7470_14150 ENOG4108MRH transcriptional regulatory protein B7470_14155 ENOG4107QJT sodium dicarboxylate symporter B7470_14160 ENOG4106F5Q Membrane B7470_14165 ENOG4105CJ1 ABC, transporter B7470_14180 ENOG4105FDT acyl-CoA dehydrogenase B7470_14200 ENOG4105SZ6 Thioredoxin B7470_14205 ENOG4105CPF Cell wall formation (By similarity) B7470_14210 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) B7470_14220 ENOG4105C1J atp-dependent rna helicase B7470_14225 ENOG410905X membrane-flanked domain protein B7470_14230 ENOG4105CKV Membrane B7470_14240 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) B7470_14245 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein B7470_14250 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) B7470_14260 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) B7470_14265 ENOG4107MMM Anti-sigma-factor antagonist B7470_14270 ENOG4105FUA antagonist B7470_14275 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase B7470_14280 ENOG4107SGM protein serine threonine phosphatase B7470_14285 ENOG4105WN5 stage II sporulation protein B7470_14290 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) B7470_14300 ENOG41064BQ Phosphatase B7470_14315 ENOG4105M5P UPF0310 protein B7470_14320 ENOG4105RV9 Transcriptional regulator B7470_14370 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) B7470_14375 ENOG41068WC Domain of unknown function (DUF955) B7470_14380 ENOG4108IMY Transcriptional regulator B7470_14400 ENOG4108RYM conjugative transposon protein B7470_14405 ENOG4106BHR ftsk SpoIIIE family protein B7470_14410 ENOG4106128 DNA-binding helix-turn-helix protein B7470_14455 ENOG4105P1M Domain of unknown function (DUF1874) B7470_14470 ENOG4105K4H Nlp p60 protein B7470_14515 ENOG4107V2S Transcriptional regulator B7470_14530 ENOG4106BHF B7470_14535 ENOG4105VZ8 Transcriptional regulator B7470_14560 ENOG4108V4B ThiJ pfpI B7470_14565 ENOG4105VEQ Cold shock protein B7470_14570 ENOG4108VJ1 Transcriptional regulator (CarD family B7470_14585 ENOG4108MCI Transcriptional regulator, ARAC family B7470_14595 ENOG41086D8 Transcriptional regulator B7470_14600 ENOG4107U9B transcriptional regulator B7470_14615 ENOG4105CZ9 Domain of unknown function (DU1801) B7470_14620 ENOG4105GIG B7470_14630 ENOG4105KRI phosphocarrier protein (HPr B7470_14635 ENOG4105ST3 Transcriptional regulator B7470_14640 ENOG4105T38 integral membrane protein B7470_14645 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B7470_14650 ENOG4108ZMQ domain protein B7470_14655 ENOG4105MJ9 esterase B7470_14670 ENOG41082YX Transcriptional regulator, arsr family B7470_14675 ENOG4107R5R arsenical pump membrane protein B7470_14685 ENOG4105Z7P Acetyltransferase (GNAT) family B7470_14690 ENOG4107Y9U Membrane B7470_14700 ENOG4105DY8 decarboxylase B7470_14705 ENOG4108SQ9 flavin reductase domain protein, FMN-binding B7470_14710 ENOG4108ZHR arsR family transcriptional regulator B7470_14715 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) B7470_14730 ENOG4105ENE Histidine kinase B7470_14735 ENOG4108VB1 regulatoR B7470_14740 ENOG4105EYF MMPL domain protein B7470_14745 ENOG4108WC5 Alpha Beta Hydrolase Fold protein B7470_14750 ENOG4108UQV Membrane B7470_14755 ENOG4108Z5V transcriptional regulator, merr family B7470_14760 ENOG41076HS cation diffusion facilitator family transporter B7470_14765 ENOG4108TVJ Nitroreductase B7470_14770 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase B7470_14775 ENOG4108VGI doxx family B7470_14780 ENOG4105XXY Thioredoxin B7470_14805 ENOG4108QY0 Membrane B7470_14825 ENOG4105PF9 Transcriptional regulator B7470_14835 ENOG4105WQG acetyltransferase B7470_14845 ENOG4105C85 amino acid B7470_14855 ENOG41062A4 Transcriptional regulator B7470_14860 ENOG4105EYF MMPL domain protein B7470_14865 ENOG4108TVJ Nitroreductase B7470_14870 ENOG4105FS7 Transcriptional regulator B7470_14875 ENOG4105C2C drug resistance transporter, Bcr CflA B7470_14885 ENOG4105DRR Transcriptional regulator, GntR family B7470_14890 ENOG4105VRS hydrolase family 18 B7470_14905 ENOG4105G6Z alkaline phosphatase B7470_14910 ENOG4108ZMX Domain of unknown function (DU1801) B7470_14920 ENOG4108YM7 Gcn5-related n-acetyltransferase B7470_14925 ENOG4107TVP HD domain protein B7470_14930 ENOG41090UD (LipO)protein B7470_14935 ENOG4105F27 Major Facilitator B7470_14940 ENOG4105VZJ PTS System B7470_14955 ENOG4105CS2 ec 3.2.1.21 B7470_14960 ENOG4108TZY GntR Family Transcriptional Regulator B7470_14965 ENOG4105EVU fructokinase B7470_14975 ENOG4105D3P Mannan endo-1,4-beta-mannosidase B7470_15020 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) B7470_15025 ENOG4105K8N protein family UPF0079, ATPase B7470_15030 ENOG41072GX Peptidase M22 Glycoprotease B7470_15035 ENOG410801F ribosomal-protein-alanine acetyltransferase B7470_15040 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) B7470_15045 ENOG4105C5H ABC transporter B7470_15050 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) B7470_15055 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) B7470_15060 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) B7470_15065 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) B7470_15080 ENOG4108TYN CAAX amino terminal protease family protein B7470_15085 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) B7470_15090 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) B7470_15105 ENOG4105PGZ NB-ARC domain B7470_15110 ENOG4105CPQ Dehydrogenase B7470_15115 ENOG4105CT4 transporter B7470_15130 ENOG4105DQX Zinc finger domain B7470_15135 ENOG4108WV1 Pfam:DUF477 B7470_15145 ENOG4108ZMR Ion transport 2 domain-containing protein B7470_15150 ENOG4107QNK )-transporter B7470_15185 ENOG4107YUH hydrolase B7470_15195 ENOG4107STQ Multicopper oxidase B7470_15200 ENOG4105C85 amino acid B7470_15215 ENOG4105C7R Atpase associated with various cellular activities aaa_3 B7470_15240 ENOG4105C7N Xanthine uracil vitamin C permease B7470_15265 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) B7470_15270 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit B7470_15275 ENOG4105C83 adenylosuccinate lyase B7470_15280 ENOG4105C8V SAICAR synthetase B7470_15285 ENOG4105VR9 phosphoribosylformylglycinamidine synthase B7470_15290 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I B7470_15295 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii B7470_15305 ENOG4105CXB phosphoribosylaminoimidazole synthetase B7470_15310 ENOG4108V3E phosphoribosylglycinamide formyltransferase B7470_15315 ENOG4105DC1 bifunctional purine biosynthesis protein purh B7470_15320 ENOG4105C12 Phosphoribosylglycinamide synthetase B7470_15330 ENOG4105DVH amino acid B7470_15345 ENOG4108R5T secreted protein B7470_15350 ENOG4105KGF protein, YerC YecD B7470_15355 ENOG4105CBC glutamate synthase B7470_15360 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) B7470_15365 ENOG4105C4R Atp-dependent dna helicase B7470_15370 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) B7470_15385 ENOG4105CRN Aminoglycoside phosphotransferase B7470_15390 ENOG4105KT7 mgtC SapB transporter B7470_15395 ENOG4105CK7 Sodium proline symporter B7470_15400 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) B7470_15405 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) B7470_15410 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) B7470_15425 ENOG4105CBD Diacylglycerol kinase B7470_15430 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) B7470_15480 ENOG4105CDY transcriptional regulatory protein B7470_15490 ENOG4105M4P Tetr family transcriptional regulator B7470_15505 ENOG4105WEF catalase B7470_15510 ENOG4105M18 -acetyltransferase B7470_15525 ENOG4105C2F Histidine kinase B7470_15535 ENOG410769Z extracellular solute-binding protein family 1 B7470_15540 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component B7470_15545 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component B7470_15550 ENOG4105F5H Glycosyl Hydrolase Family 88 B7470_15555 ENOG41075H3 AraC family transcriptional regulator B7470_15560 ENOG4107TDE lipolytic protein G-D-S-L family B7470_15575 ENOG4105CX8 fg-gap repeat protein B7470_15580 ENOG4105CX8 fg-gap repeat protein B7470_15585 ENOG4107TDE lipolytic protein G-D-S-L family B7470_15600 ENOG4105E0S extracellular solute-binding protein family 1 B7470_15610 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component B7470_15615 ENOG4105F8D glycoside hydrolase family 4 B7470_15620 ENOG4105H67 Protein of unknown function (DUF421) B7470_15625 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) B7470_15630 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily B7470_15650 ENOG4106I4J membrane B7470_15655 ENOG41061H0 Monooxygenase B7470_15670 ENOG4108R1P B7470_15675 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) B7470_15685 ENOG4105E0M Sulfatase B7470_15690 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase B7470_15700 ENOG41090R9 glycosyltransferase B7470_15705 ENOG4107R51 Glycosyl transferase, family 2 B7470_15710 ENOG41090R9 glycosyltransferase B7470_15715 ENOG4105EU0 Major facilitator Superfamily B7470_15725 ENOG4105CUB amino acid B7470_15730 ENOG4105C26 Dehydrogenase B7470_15735 ENOG4105FKZ Methyl-accepting chemotaxis B7470_15740 ENOG4105C5H ABC transporter B7470_15750 ENOG4107SWG transcriptional regulator MERR family B7470_15755 ENOG4105DXB Major Facilitator superfamily B7470_15770 ENOG4105C5H ABC transporter B7470_15775 ENOG4105FDU atp-dependent rna helicase B7470_15785 ENOG4108J20 pectate lyase B7470_15790 ENOG4107QPK )-transporter B7470_15800 ENOG4108MRH transcriptional regulatory protein B7470_15825 ENOG410855V Acylphosphatase B7470_15830 ENOG4108RPX mosc domain containing protein B7470_15850 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) B7470_15885 ENOG4105E1K spore germination protein B7470_15890 ENOG4105C5Y PTS System B7470_15895 ENOG4105CG3 alpha amylase, catalytic region B7470_15900 ENOG4107414 GntR family transcriptional regulator B7470_15905 ENOG4108RCM Nitroreductase B7470_15910 ENOG4105CGH 5'-nucleotidase B7470_15915 ENOG4107RKG DJ-1/PfpI family B7470_15935 ENOG4105KJF protein tyrosine phosphatase B7470_15945 ENOG4107U9T Pfam:Ribonuclease_BN B7470_15950 ENOG4108ISG Major Facilitator B7470_15955 ENOG4105UPD Calcium Proton B7470_15965 ENOG4105D8X mechanosensitive ion channel B7470_15985 ENOG4106KE4 Dehydrogenase B7470_15990 ENOG4105D7N magnesium and cobalt transport protein CorA B7470_16000 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) B7470_16025 ENOG4107RUY (E1 component), alpha subunit B7470_16035 ENOG4107QKR Dehydrogenase B7470_16045 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family B7470_16050 ENOG41069DP small acid-soluble spore protein B7470_16055 ENOG4105KK4 UPF0060 membrane protein B7470_16085 ENOG4105F8D glycoside hydrolase family 4 B7470_16090 ENOG4108Q3X Transcriptional regulator B7470_16095 ENOG4105CI1 PTS System B7470_16105 ENOG4105BZ1 (ABC) transporter B7470_16110 ENOG4105BZ1 (ABC) transporter B7470_16120 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase B7470_16125 ENOG4105ID8 Transcriptional regulator, ARAC family B7470_16130 ENOG4107QNK )-transporter B7470_16135 ENOG4107QP6 Xylose isomerase domain protein TIM barrel B7470_16145 ENOG4105BZU Histidine kinase B7470_16150 ENOG4105WH1 Two component transcriptional regulator luxr family B7470_16155 ENOG4105CJ1 ABC, transporter B7470_16160 ENOG41090VJ ABC-2 type transporter B7470_16165 ENOG4108KYE ABC-2 type transporter B7470_16170 ENOG4105U3E Transcriptional regulator B7470_16175 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold B7470_16180 ENOG4105H93 Acyltransferase family B7470_16185 ENOG4105YA8 Transcriptional regulator B7470_16190 ENOG4107Y80 Major Facilitator superfamily B7470_16195 ENOG4108YYS metal-dependent hydrolase (By similarity) B7470_16205 ENOG410834F Transcriptional regulator B7470_16215 ENOG4108MES Periplasmic binding protein B7470_16220 ENOG4105DQ5 transport system permease protein B7470_16225 ENOG4108IHU transport system permease protein B7470_16230 ENOG4105JAB phenazine biosynthesis protein, phzf family B7470_16235 ENOG4107Y03 Nitroreductase B7470_16250 ENOG4105ECP epimerase B7470_16265 ENOG4105F27 Major Facilitator B7470_16285 ENOG4106AKJ B7470_16290 ENOG4105D74 hydrolase B7470_16295 ENOG4105CKK Glycosyl transferase, family 2 B7470_16300 ENOG4105EJV Membrane B7470_16305 ENOG41067AE Membrane-bound metal-dependent hydrolase B7470_16310 ENOG4105CEN a g-specific adenine glycosylase B7470_16315 ENOG4106BXE B7470_16320 ENOG4105CAN Short-chain dehydrogenase reductase Sdr B7470_16335 ENOG4105EVI UPF0374 protein B7470_16340 ENOG4105BZ1 (ABC) transporter B7470_16345 ENOG4107NBY Membrane B7470_16355 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B7470_16360 ENOG4105G5W regulator Fur family B7470_16470 ENOG4108N23 SpoOM-related protein B7470_16485 ENOG4105EC3 peptidase S51, dipeptidase E B7470_16490 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) B7470_16510 ENOG4105E2Y ABC, transporter B7470_16515 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein B7470_16520 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component B7470_16525 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) B7470_16535 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) B7470_16540 ENOG4107D63 B7470_16545 ENOG4105VZ8 Transcriptional regulator B7470_16560 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) B7470_16570 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) B7470_16590 ENOG4105CYN Serine protein kinase B7470_16595 ENOG4106AKX UPF0229 protein B7470_16600 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes B7470_16605 ENOG4105CW7 secretion protein, HlyD family B7470_16610 ENOG4105C0R drug resistance transporter emrb qaca subfamily B7470_16615 ENOG4105CS1 NAD(P)H quinone oxidoreductase B7470_16635 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family B7470_16640 ENOG4105CZV ABC transporter B7470_16645 ENOG4105CJ1 ABC, transporter B7470_16650 ENOG4108TU7 Inherit from COG: (ABC) transporter B7470_16655 ENOG4105VEQ Cold shock protein B7470_16670 ENOG4105BZU Histidine kinase B7470_16705 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) B7470_16710 ENOG4106128 DNA-binding helix-turn-helix protein B7470_16755 ENOG4105P1M Domain of unknown function (DUF1874) B7470_16765 ENOG4105K4H Nlp p60 protein B7470_16825 ENOG4108YBP pseudouridine synthase B7470_16835 ENOG41080XP Cbs domain B7470_16840 ENOG4107YBY Hydrolase B7470_16845 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase B7470_16850 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) B7470_16855 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator B7470_16865 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) B7470_16870 ENOG4105C6V Glycerol-3-phosphate dehydrogenase B7470_16880 ENOG4105BZU Histidine kinase B7470_16885 ENOG4105WH1 Two component transcriptional regulator luxr family B7470_16920 ENOG4105ED1 spovr family B7470_16925 ENOG4105G6Z alkaline phosphatase B7470_16940 ENOG4105BZN citrate synthase B7470_16945 ENOG4105CYX Short-chain dehydrogenase reductase Sdr B7470_16950 ENOG4105CUB amino acid B7470_16955 ENOG4105C8J )-transporter B7470_16960 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B7470_16975 ENOG4105J37 B7470_16980 ENOG4108AEY RNA polymerase sigma factor B7470_16985 ENOG4108FN7 Aldo keto reductase B7470_16990 ENOG4105F6E Acyl-transferase B7470_16995 ENOG4105C37 (CBS) domain B7470_17010 ENOG4105C37 (CBS) domain B7470_17020 ENOG4105WMR Protein CrcB homolog B7470_17025 ENOG4108QXE glycerophosphoryl diester phosphodiesterase B7470_17035 ENOG4105D64 Mechanosensitive ion channel B7470_17040 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) B7470_17045 ENOG4107VMI polysaccharide deacetylase B7470_17050 ENOG4105F0I Aminotransferase B7470_17070 ENOG4105BZ1 (ABC) transporter B7470_17075 ENOG4105BZ1 (ABC) transporter B7470_17105 ENOG410839P B7470_17115 ENOG4106MP8 UPF0754 membrane protein B7470_17120 ENOG4105WZB UPF0342 protein B7470_17135 ENOG4105D4P Coproporphyrinogen iii oxidase B7470_17140 ENOG4107S91 Sodium hydrogen exchanger B7470_17145 ENOG4105NCW Trka-c domain protein B7470_17155 ENOG4105CGU Enoyl-CoA hydratase B7470_17165 ENOG4108IUX (ABC) transporter B7470_17170 ENOG4105RHA ABC transporter, permease B7470_17175 ENOG4107VRP DNA repair exonuclease B7470_17180 ENOG4106D4I domain protein B7470_17185 ENOG4105EQI Metal Dependent Phosphohydrolase B7470_17195 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) B7470_17240 ENOG4105NBU tryptophan transport protein B7470_17245 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) B7470_17250 ENOG4105K59 histidine triad (HIT) protein B7470_17285 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation B7470_17290 ENOG4105BZ4 penicillin-binding protein B7470_17295 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) B7470_17300 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) B7470_17305 ENOG4105C1Q protoporphyrinogen oxidase B7470_17315 ENOG4105ECB domain protein B7470_17325 ENOG41090T1 Membrane B7470_17335 ENOG4105DER m42 family B7470_17350 ENOG4106AXD B7470_17355 ENOG4108RQ5 Beta-lactamase domain-containing protein B7470_17360 ENOG4105DF9 Lipoate-protein, ligase B7470_17370 ENOG4105CEY Amp-dependent synthetase and ligase B7470_17380 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 B7470_17390 ENOG4105KD7 acetyltransferase B7470_17400 ENOG4108HUF Transporter B7470_17405 ENOG4107TB6 phosphoglycerate mutase B7470_17415 ENOG4107F3J Amp-dependent synthetase and ligase B7470_17420 ENOG4107ZYJ bioY protein B7470_17425 ENOG4106YBV Methyl-accepting chemotaxis B7470_17445 ENOG4105XVF Competence transcription factor B7470_17450 ENOG4105CYX Short-chain dehydrogenase reductase Sdr B7470_17455 ENOG4105X3H Excalibur domain protein B7470_17460 ENOG4105E1V na solute symporter B7470_17465 ENOG4106CAD Protein of unknown function (DUF3311) B7470_17470 ENOG41060YP B7470_17485 ENOG4107SCK Monooxygenase B7470_17490 ENOG4108INS Transcriptional regulator B7470_17515 ENOG4105TRI Hydrolase B7470_17530 ENOG4108KK1 membrane protein AbrB duplication B7470_17535 ENOG4106K7D Major facilitator family transporter B7470_17540 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) B7470_17555 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding B7470_17570 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation B7470_17580 ENOG4105EYH Exonuclease B7470_17630 ENOG4105ERH Fumarylacetoacetate hydrolase B7470_17640 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin B7470_17650 ENOG4105CAQ asparagine synthetase B7470_17660 ENOG4105UQX Mate efflux family protein B7470_17665 ENOG4106HBX Transcriptional Regulator AraC Family B7470_17670 ENOG4105ETE Transcriptional regulator (LacI family B7470_17675 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) B7470_17680 ENOG4105SF0 DinB family B7470_17685 ENOG4108ZUB Lysine exporter protein (Lyse ygga) B7470_17690 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family B7470_17695 ENOG4105MYW Pentapeptide repeat protein B7470_17700 ENOG4107S9D Alpha beta hydrolase B7470_17710 ENOG4105MA6 gCN5-related N-acetyltransferase B7470_17720 ENOG4108VPT UPF0234 protein B7470_17725 ENOG4105QNR S1 RNA binding domain protein B7470_17730 ENOG410751J B7470_17735 ENOG4105EPR degv family B7470_17740 ENOG4107AYK membrAne B7470_17750 ENOG41073B9 B7470_17755 ENOG4108KP7 hydrolase B7470_17760 ENOG4108MXZ Esterase B7470_17765 ENOG4105VG1 fes assembly suf system protein B7470_17785 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase B7470_17800 ENOG4105C8Y Acetylornithine aminotransferase B7470_17805 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain B7470_17815 ENOG4105DBV ornithine carbamoyltransferase B7470_17845 ENOG4107RMD Basic membrane lipoprotein B7470_17860 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) B7470_17865 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) B7470_17875 ENOG4105C3U ABC transporter B7470_17880 ENOG4108JQ7 (ABC) transporter B7470_17895 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B7470_17905 ENOG4105C31 Tryptophanyl-tRNA synthetase B7470_17910 ENOG4108J59 Extracellular solute-binding protein, family 5 B7470_17915 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B7470_17920 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B7470_17930 ENOG4108JQ7 (ABC) transporter B7470_17945 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) B7470_17950 ENOG4108ZCF integral membrane protein B7470_17955 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis B7470_17965 ENOG4105DPN Oligoendopeptidase f B7470_17980 ENOG4105T58 Dithiol-disulfide isomerase B7470_17985 ENOG4108Z18 K06886 hemoglobin B7470_17990 ENOG4105E4C Lytic transglycosylase catalytic B7470_17995 ENOG4105MIX Adenylate cyclase B7470_18010 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) B7470_18015 ENOG4105EMS pseudouridine synthase B7470_18030 ENOG4105ETU transcriptional activator (TenA B7470_18035 ENOG4108VEU Thiamine monophosphate synthase B7470_18050 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) B7470_18055 ENOG4105D06 uba thif-type nad fad binding protein B7470_18060 ENOG4105DWF phosphomethylpyrimidine kinase B7470_18065 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH B7470_18070 ENOG4107A88 B7470_18120 ENOG4105ENA helicase B7470_18135 ENOG4108ZMI UPF0477 protein B7470_18145 ENOG4105C28 cystathionine B7470_18150 ENOG4105C28 cystathionine B7470_18155 ENOG4105D9U N-acetyltransferase B7470_18160 ENOG4105JHY Membrane B7470_18235 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) B7470_18270 ENOG410780I phosphoprotein phosphatase activity B7470_18275 ENOG4106BHF B7470_18280 ENOG4106ANW SMI1_KNR4 B7470_18360 ENOG4105DM4 PTS System B7470_18365 ENOG4105DG6 mannose-6-phosphate isomerase B7470_18370 ENOG4105G7B Protein of unknown function (DUF2992) B7470_18380 ENOG4105VMI -acetyltransferase B7470_18390 ENOG4108Z66 YbaK ebsC protein B7470_18410 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) B7470_18420 ENOG4108ZJ4 polysaccharide deacetylase B7470_18425 ENOG4107CUJ Protein of unknown function (DUF2690) B7470_18475 ENOG4106A3M Cytochrome p-450 B7470_18480 ENOG41087PP glycosyltransferase MGT family B7470_18490 ENOG4105EXQ uroporphyrinogen iii synthase hem4 B7470_18495 ENOG4105C4B ABC transporter, permease B7470_18500 ENOG4108IXI (ABC) transporter B7470_18525 ENOG4105D2H Uronic isomerase B7470_18530 ENOG4105CT4 transporter B7470_18535 ENOG4105DG4 malate L-lactate dehydrogenase B7470_18540 ENOG4105CPQ Dehydrogenase B7470_18545 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) B7470_18550 ENOG4105DMW Dehydrogenase reductase B7470_18555 ENOG4108I5G Major Facilitator superfamily B7470_18560 ENOG4107KJX Transcriptional regulator B7470_18565 ENOG4107QZW Altronate oxidoreductase B7470_18570 ENOG4105CTX dehydratase B7470_18575 ENOG4107TSN permease B7470_18595 ENOG4105JD4 ATPase yjob B7470_18615 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase B7470_18620 ENOG4105KWG Pfam:DUF1696 B7470_18625 ENOG4105K7W phage-related replication protein B7470_18630 ENOG4105WEF catalase B7470_18635 ENOG410635T phage-like element pbsx protein B7470_18680 ENOG4108TFU terminase (Small subunit) B7470_18685 ENOG4105IG6 Phage terminase, large subunit B7470_18690 ENOG4108MDF Phage Portal Protein B7470_18715 ENOG41060SN B7470_18730 ENOG4105PQS phage protein B7470_18735 ENOG4105FR7 XkdM protein, phage-like element PBSX B7470_18740 ENOG4105MTC XkdN-like protein B7470_18750 ENOG4108FKH Transglycosylase SLT domain B7470_18750 ENOG4108FKH Transglycosylase SLT domain B7470_18750 ENOG4108FKH Transglycosylase SLT domain B7470_18755 ENOG4108WZM domain protein B7470_18760 ENOG4105X7F B7470_18770 ENOG4105MFU Protein of unknown function (DUF2634) B7470_18775 ENOG41066EA baseplate J family protein B7470_18780 ENOG410906S phage-like element pbsx protein xkdt B7470_18790 ENOG41068G1 B7470_18820 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase B7470_18835 ENOG4105CJ3 phosphate transporter B7470_18840 ENOG4107GRR phosphate transport regulator B7470_18845 ENOG4107R7I amino acid B7470_18855 ENOG4105EDW glycosyl transferase, family 39 B7470_18860 ENOG4105CKK Glycosyl transferase, family 2 B7470_18865 ENOG4105C0H protease B7470_18875 ENOG4108ME1 Peptidase M55 D-aminopeptidase B7470_18880 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component B7470_18885 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component B7470_18890 ENOG4105C3U ABC transporter B7470_18900 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A B7470_18905 ENOG4105DTQ mandelate racemase muconate lactonizing B7470_18910 ENOG4107SN7 NLP P60 protein B7470_18915 ENOG4108JQ7 (ABC) transporter B7470_18920 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) B7470_18930 ENOG4108S4H thioesterase Superfamily protein B7470_18935 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) B7470_18955 ENOG4108428 Inherit from COG: -acetyltransferase B7470_18965 ENOG41080TC multidrug resistance protein B7470_18970 ENOG4105CIY formyltetrahydrofolate deformylase B7470_18975 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) B7470_18990 ENOG4105K56 Transcriptional regulator B7470_18995 ENOG4108ZHJ Organic hydroperoxide resistance protein B7470_19005 ENOG4107Y2X deaminase B7470_19010 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) B7470_19015 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin B7470_19025 ENOG4108W7F transporter, permease B7470_19030 ENOG4108JJB ABC transporter B7470_19035 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein B7470_19040 ENOG4108X43 YKOF domain protein B7470_19045 ENOG4105CK6 Two component transcriptional regulator (Winged helix family B7470_19050 ENOG41062D9 Histidine kinase B7470_19060 ENOG4106849 propeptide, pepSY amd peptidase M4 B7470_19075 ENOG4105CJW magnesium transporter B7470_19080 ENOG4105V75 Transcriptional regulator B7470_19125 ENOG4105DQE DNA ligase B7470_19130 ENOG4105FDF Could be involved in DNA repair (By similarity) B7470_19135 ENOG4105BZU Histidine kinase B7470_19140 ENOG4107T5V SNARE associated Golgi B7470_19145 ENOG4107TS3 membrane protein, TerC B7470_19150 ENOG4108WZW RNA polymerase sigma B7470_19160 ENOG410681C small acid-soluble spore protein B7470_19170 ENOG4105D0M Protease HtpX homolog B7470_19195 ENOG4108TGC Acyltransferase B7470_19200 ENOG4105BZU Histidine kinase B7470_19205 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) B7470_19210 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) B7470_19215 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) B7470_19220 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase B7470_19230 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit B7470_19235 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) B7470_19240 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) B7470_19245 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) B7470_19265 ENOG4105BZU Histidine kinase B7470_19270 ENOG41090MY MarR family Transcriptional regulator B7470_19275 ENOG4105ER2 Ompa motb domain protein B7470_19280 ENOG4105E14 MotA TolQ exbB proton channel B7470_19290 ENOG4108K88 Membrane B7470_19295 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) B7470_19300 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase B7470_19305 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) B7470_19310 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) B7470_19330 ENOG4105F0V Cell wall hydrolase B7470_19345 ENOG4105C59 p-type ATPase B7470_19355 ENOG4105DC7 peptidase M24 B7470_19365 ENOG4105CID antiterminator B7470_19375 ENOG4105KRI phosphocarrier protein (HPr B7470_19380 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) B7470_19390 ENOG4105F6S Spore photoproduct lyase B7470_19400 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer B7470_19405 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase B7470_19415 ENOG4105K4I Scp-like extracellular B7470_19425 ENOG4105BZU Histidine kinase B7470_19430 ENOG4105CHM Aminotransferase B7470_19440 ENOG4107R88 Chemotaxis protein (CheV) B7470_19445 ENOG4105UIN B7470_19455 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein B7470_19465 ENOG4105K6S Short-chain dehydrogenase reductase Sdr B7470_19470 ENOG4105EPM Diguanylate phosphodiesterase B7470_19475 ENOG4107IN1 Protein of unknown function (DUF1797) B7470_19480 ENOG4108XRC Protein of unknown function (DUF458) B7470_19510 ENOG4105NQC Flavodoxin B7470_19520 ENOG4105CH2 amidohydrolase B7470_19530 ENOG4105D8X mechanosensitive ion channel B7470_19535 ENOG4105D3R alkyl hydroperoxide reductase B7470_19540 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B7470_19560 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) B7470_19565 ENOG4105D06 uba thif-type nad fad binding protein B7470_19570 ENOG4105CVM Molybdenum cofactor synthesis domain protein B7470_19575 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein B7470_19580 ENOG4108ZAF Molybdopterin B7470_19585 ENOG41067WU Molybdopterin converting factor (Subunit 1) B7470_19595 ENOG4105BZ1 (ABC) transporter B7470_19605 ENOG4107X8C Efflux transporter RND family MFP subunit B7470_19610 ENOG4105C19 ABC transporter B7470_19615 ENOG4107RBB ABC transporter, permease B7470_19620 ENOG4105E98 transcriptional regulator DeoR family B7470_19625 ENOG4105DE4 1-phosphofructokinase B7470_19630 ENOG4105DM4 PTS System B7470_19635 ENOG4105C3F Signal peptidase i B7470_19645 ENOG4105C5H ABC transporter B7470_19650 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) B7470_19675 ENOG4105BZU Histidine kinase B7470_19685 ENOG4107ZYR domain protein B7470_19695 ENOG4105CN5 Metallo-Beta-Lactamase B7470_19705 ENOG4108X4Q Hydrolase B7470_19710 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) B7470_19730 ENOG4105CPP Dehydrogenase, E1 component B7470_19735 ENOG4105C7S Dehydrogenase B7470_19740 ENOG4107QN2 dihydrolipoyl dehydrogenase B7470_19755 ENOG4105CXN decarboxylase B7470_19760 ENOG4105WBI UPF0223 protein B7470_19775 ENOG4105ECY inositol monophosphatase B7470_19790 ENOG4105JQZ Methyltransferase B7470_19835 ENOG4105CI3 gtp-binding protein typa B7470_19840 ENOG4105QA2 B7470_19855 ENOG4108IAB Phoh family B7470_19865 ENOG4105CSV Glutaminase B7470_19870 ENOG4105ZPI UPF0358 protein B7470_19875 ENOG4105CNI cell division protein FtsW B7470_19880 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) B7470_19890 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) B7470_19900 ENOG4105BZ9 Cytochrome C oxidase, subunit I B7470_19905 ENOG4105CCU oxidase (Subunit III) B7470_19910 ENOG41064X9 cytochrome C oxidase subunit IV B7470_19925 ENOG41080XQ Signal transduction protein with cbs domains B7470_19930 ENOG4106UY4 Inherit from COG: Scp-like extracellular B7470_19950 ENOG4105WUC UPF0298 protein B7470_19955 ENOG4106H78 methyltransferase B7470_19960 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) B7470_19965 ENOG4105H20 Sporulation integral membrane protein YlbJ B7470_19970 ENOG4105D78 K07001 NTE family protein B7470_19975 ENOG41063PX domain protein B7470_19980 ENOG4105CDE UPF0348 protein B7470_19990 ENOG4105KNH Nucleic acid-binding protein B7470_19995 ENOG41067VY 50S ribosomal protein L32 B7470_20020 ENOG4108V6E Cell division protein mraZ B7470_20025 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) B7470_20035 ENOG4105CJN penicillin-binding protein B7470_20040 ENOG4105CJN penicillin-binding protein B7470_20045 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) B7470_20050 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) B7470_20055 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) B7470_20060 ENOG4105CNI cell division protein FtsW B7470_20065 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) B7470_20070 ENOG4105D4A Cell wall formation (By similarity) B7470_20075 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) B7470_20080 ENOG4108R2U division initiation protein B7470_20090 ENOG4105K67 small basic protein B7470_20095 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) B7470_20100 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) B7470_20110 ENOG4105FFI sigma-e processing peptidase spoiiga B7470_20115 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B7470_20125 ENOG4105DKW ABC transporter B7470_20135 ENOG4105WR5 sporulation protein, YlmC YmxH family B7470_20140 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase B7470_20145 ENOG4105DFA alanine racemase domain protein B7470_20150 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) B7470_20155 ENOG41067XK integral membrane protein B7470_20160 ENOG4105DBK s4 domain protein B7470_20170 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) B7470_20180 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) B7470_20185 ENOG4105C34 Pseudouridine synthase B7470_20190 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) B7470_20200 ENOG4105CXT aspartate transcarbamylase B7470_20210 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain B7470_20215 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain B7470_20220 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) B7470_20225 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) B7470_20230 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) B7470_20235 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) B7470_20240 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) B7470_20250 ENOG4107S4M Sulfate adenylate transferase B7470_20255 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) B7470_20260 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) B7470_20265 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein B7470_20270 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein B7470_20275 ENOG4105F23 Fibronectin-binding protein B7470_20285 ENOG4105DSJ YicC domain protein B7470_20290 ENOG4105KC4 UPF0296 protein B7470_20295 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) B7470_20305 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase B7470_20310 ENOG4105C25 Primosomal protein n' B7470_20315 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) B7470_20320 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) B7470_20325 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B B7470_20330 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs B7470_20335 ENOG4108ZF3 Phosphatase B7470_20340 ENOG4105D9P serine threonine protein kinase B7470_20345 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) B7470_20350 ENOG4105DJV ribulose-phosphate 3-epimerase B7470_20355 ENOG4105FJ0 thiamine B7470_20365 ENOG4105VB9 50S ribosomal protein l28 B7470_20370 ENOG4108ZAA Alkaline-shock protein B7470_20375 ENOG4105DP4 dak2 domain fusion protein ylov B7470_20385 ENOG4105EJQ L-serine dehydratase B7470_20390 ENOG4105CB5 ATP-dependent DNA helicase recG B7470_20395 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) B7470_20405 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase B7470_20410 ENOG4105CHR reductase B7470_20415 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) B7470_20420 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) B7470_20425 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) B7470_20430 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) B7470_20440 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) B7470_20450 ENOG4105K5M 30s ribosomal protein S16 B7470_20455 ENOG4108BW8 UPF0109 protein B7470_20465 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) B7470_20470 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) B7470_20475 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) B7470_20480 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) B7470_20485 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) B7470_20495 ENOG4105VM1 flagellar B7470_20500 ENOG4105CMV Succinyl-CoA synthetase subunit beta B7470_20505 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha B7470_20510 ENOG4105C79 DNA protecting protein DprA B7470_20515 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) B7470_20520 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) B7470_20525 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B7470_20530 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) B7470_20535 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) B7470_20545 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) B7470_20550 ENOG4108ZC9 flagellar basal-body rod protein flgc B7470_20555 ENOG4105VQ0 flagellar hook-basal body complex protein fliE B7470_20565 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) B7470_20580 ENOG4106YF4 Flagellar biosynthesis chaperone B7470_20590 ENOG410696Y Flagellar hook-length control protein B7470_20595 ENOG410822I Flagellar hook capping protein B7470_20600 ENOG4108JQA flagellar B7470_20605 ENOG41068WV flagellar FlbD family protein B7470_20615 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) B7470_20620 ENOG4105DD5 Flagellar motor switch protein B7470_20625 ENOG4107YTP response regulator receiver protein B7470_20635 ENOG4105CN7 Flagellar biosynthetic protein FliP B7470_20640 ENOG4105VS8 Flagellar biosynthetic protein fliq B7470_20650 ENOG4105D00 flagellar biosynthetic protein flhB B7470_20655 ENOG4105D7B Flagellar biosynthesis protein flha B7470_20660 ENOG4105FZW flagellar biosynthesis regulator FlhF B7470_20670 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) B7470_20675 ENOG4105CBS Chea signal transduction histidine kinase B7470_20680 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis B7470_20695 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) B7470_20705 ENOG4105CE9 30S ribosomal protein S2 B7470_20710 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) B7470_20720 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) B7470_20725 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) B7470_20730 ENOG4105KNE Phosphatidate cytidylyltransferase B7470_20740 ENOG4105DZP Membrane-associated zinc metalloprotease B7470_20745 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) B7470_20750 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) B7470_20755 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) B7470_20760 ENOG4105CHV Transcription elongation factor NusA B7470_20765 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination B7470_20770 ENOG4105VHM ribosomal protein B7470_20775 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) B7470_20780 ENOG4105W7A Protein of unknown function (DUF503) B7470_20785 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) B7470_20790 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) B7470_20795 ENOG4105DTN riboflavin biosynthesis protein ribF B7470_20800 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) B7470_20805 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) B7470_20815 ENOG4105C1V Peptidase, M16 B7470_20825 ENOG4105E35 Dipicolinate synthase subunit A B7470_20830 ENOG4108S0H Dipicolinic acid synthetase, b subunit B7470_20835 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) B7470_20845 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) B7470_20855 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit B7470_20865 ENOG4105CNU cell division protein FtsK B7470_20870 ENOG4105FDP GntR family transcriptional regulator B7470_20890 ENOG4108RKS Short-chain dehydrogenase reductase Sdr B7470_20895 ENOG4105XZV Protein of unknown function (DUF3243) B7470_20910 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase B7470_20915 ENOG4105CEV competence damage-inducible protein B7470_20925 ENOG4108A04 Beta-lactamase B7470_20930 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) B7470_20935 ENOG4105D48 metallophosphoesterase B7470_20940 ENOG4105MCT stage V sporulation protein S B7470_20950 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) B7470_20955 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) B7470_20970 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) B7470_20975 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) B7470_21070 ENOG4105IIP Membrane B7470_21075 ENOG4105W1N transcriptional regulator B7470_21090 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin B7470_21100 ENOG4105K7W phage-related replication protein B7470_21105 ENOG4108X3M OsmC Ohr family protein B7470_21110 ENOG410814C multidrug resistance protein B7470_21130 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) B7470_21135 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) B7470_21150 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) B7470_21155 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B7470_21160 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) B7470_21165 ENOG4105U6W MutT NUDIX family protein B7470_21170 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase B7470_21180 ENOG4106F1P AAA ATPase, central domain protein B7470_21185 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) B7470_21190 ENOG4105CXI aluminum resistance protein B7470_21195 ENOG4105KV4 Transcriptional regulator B7470_21200 ENOG4105C5F glutamine synthetase B7470_21205 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) B7470_21225 ENOG4108ZUE Phage regulatory protein rha B7470_21370 ENOG4108FKH Transglycosylase SLT domain B7470_21390 ENOG41068G1 B7470_21415 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase B7470_21420 ENOG4106ANW SMI1_KNR4 B7470_21425 ENOG4106BHF B7470_21445 ENOG41079P0 B7470_21475 ENOG4105EN2 IstB domain-containing protein ATP-binding protein B7470_21480 ENOG4106QJ6 Integrase catalytic subunit B7470_21500 ENOG4107NTZ B7470_21525 ENOG410907G B7470_21530 ENOG4105CT4 transporter B7470_21545 ENOG4105DSG hydrolase family 43 B7470_21550 ENOG4105E2R ROK family B7470_21555 ENOG4105C93 Xylose Isomerase B7470_21560 ENOG4105CMG Carbohydrate kinase B7470_21575 ENOG4107Y9E nuclease B7470_21580 ENOG4105C54 Major Facilitator superfamily B7470_21585 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) B7470_21600 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) B7470_21690 ENOG4105FVX B7470_21700 ENOG4105K7W phage-related replication protein B7470_21710 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) B7470_21720 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) B7470_21730 ENOG4108SVB resolvase B7470_21735 ENOG4105VPS UPF0291 protein B7470_21740 ENOG4105CV1 Transketolase (EC 2.2.1.1) B7470_21760 ENOG4107QIV Cytochrome c biogenesis protein B7470_21785 ENOG4107DZX Small, acid-soluble spore protein P B7470_21795 ENOG4108I0Z Aconitate hydratase B7470_21800 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen B7470_21815 ENOG41067CD Small, acid-soluble spore protein Tlp B7470_21825 ENOG4105MI2 B7470_21830 ENOG4105W8X HesB YadR YfhF-family protein B7470_21835 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) B7470_21840 ENOG4105K4P CoA-binding domain protein B7470_21845 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) B7470_21865 ENOG4107QWR cellulase (EC 3.2.1.4) B7470_21875 ENOG4108MYR Secreted protein B7470_21890 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase B7470_21895 ENOG4107T5V SNARE associated Golgi B7470_21905 ENOG4107QX3 carboxylase B7470_21910 ENOG4105E39 Enoyl-CoA hydratase B7470_21915 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase B7470_21920 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit B7470_21925 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase B7470_21930 ENOG4105CEY Amp-dependent synthetase and ligase B7470_21935 ENOG4105C1G acyl-Coa dehydrogenase B7470_21945 ENOG4105F32 YngK protein B7470_21950 ENOG4106U2H Protein of unknown function (DUF1360) B7470_21960 ENOG4105CEY Amp-dependent synthetase and ligase