locus-tag	class	description
KO64_00010	COG0230	Belongs to the bacterial ribosomal protein bL34 family
KO64_00020	COG0592	DNA-directed DNA polymerase activity
KO64_00025	COG2501	S4 domain
KO64_00040	COG0187	DNA topoisomerase II activity
KO64_00045	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KO64_00080	COG0516	GMP reductase activity
KO64_00080	COG0517	IMP dehydrogenase activity
KO64_00085	COG1686	Belongs to the peptidase S11 family
KO64_00105	COG1929	Belongs to the glycerate kinase type-1 family
KO64_00115	COG1428	Deoxynucleoside kinase
KO64_00120	COG1428	Deoxynucleoside kinase
KO64_00125	COG3858	chitin binding
KO64_00125	COG1388	LysM domain
KO64_00130	COG1335	isochorismatase
KO64_00135	COG0590	tRNA wobble adenosine to inosine editing
KO64_00140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
KO64_00145	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
KO64_00195	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
KO64_00200	COG3853	Toxic anion resistance protein (TelA)
KO64_00205	COG1982	Orn Lys Arg decarboxylase major
KO64_00215	COG3870	Protein conserved in bacteria
KO64_00220	COG1728	Protein conserved in bacteria
KO64_00225	COG0470	DNA polymerase III
KO64_00230	COG1774	PSP1 C-terminal conserved region
KO64_00240	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
KO64_00250	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
KO64_00255	COG2002	toxin-antitoxin pair type II binding
KO64_00260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KO64_00260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KO64_00265	COG0084	hydrolase, TatD family'
KO64_00270	COG3583	domain protein
KO64_00270	COG3584	3D domain protein
KO64_00275	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KO64_00280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
KO64_00290	COG4466	Protein conserved in bacteria
KO64_00305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
KO64_00310	COG0251	oxidation-reduction process
KO64_00325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
KO64_00345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
KO64_00350	COG2002	toxin-antitoxin pair type II binding
KO64_00355	COG2244	polysaccharide biosynthetic process
KO64_00360	COG3956	TIGRFAM MazG family protein
KO64_00365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
KO64_00380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
KO64_00385	COG1098	S1 RNA binding domain
KO64_00400	COG2208	phosphoserine phosphatase activity
KO64_00405	COG2304	oxidoreductase activity
KO64_00410	COG0515	serine threonine protein kinase
KO64_00415	COG0037	tRNA processing
KO64_00425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
KO64_00440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KO64_00445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KO64_00450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KO64_00455	COG0512	Glutamine amidotransferase of anthranilate synthase
KO64_00460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KO64_00465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
KO64_00470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
KO64_00475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
KO64_00480	COG1396	sequence-specific DNA binding
KO64_00485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KO64_00490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
KO64_00575	COG4463	regulation of RNA biosynthetic process
KO64_00580	COG3880	PFAM UvrB UvrC protein
KO64_00590	COG0542	response to heat
KO64_00595	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
KO64_00600	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
KO64_00605	COG4956	integral membrane protein (PIN domain superfamily)
KO64_00630	COG1045	serine acetyltransferase
KO64_00640	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
KO64_00645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KO64_00650	COG3688	RNA-binding protein containing a PIN domain
KO64_00655	COG1595	DNA-templated transcription, initiation
KO64_00660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KO64_00665	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KO64_00670	COG0250	Participates in transcription elongation, termination and antitermination
KO64_00675	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
KO64_00690	COG0222	ribosome binding
KO64_00695	COG2813	Specifically methylates the guanine in position
KO64_00710	COG1358	cellular component organization or biogenesis
KO64_00735	COG0596	Alpha beta hydrolase
KO64_00740	COG0051	transcription antitermination factor activity, RNA binding
KO64_00755	COG0089	rRNA binding
KO64_00765	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
KO64_00770	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
KO64_00780	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
KO64_00785	COG0255	Belongs to the universal ribosomal protein uL29 family
KO64_00835	COG1841	ribosomal large subunit assembly
KO64_00845	COG0201	protein transport
KO64_00855	COG0024	Methionine aminopeptidase
KO64_00865	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
KO64_00870	COG0257	Belongs to the bacterial ribosomal protein bL36 family
KO64_00895	COG1122	ATPase activity
KO64_00900	COG1122	ATPase activity
KO64_00905	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KO64_00925	COG2226	methyltransferase
KO64_00930	COG2318	DinB family
KO64_00940	COG0860	N-Acetylmuramoyl-L-alanine amidase
KO64_00945	COG0489	protein tyrosine kinase activity
KO64_00955	COG2194	sulfuric ester hydrolase activity
KO64_00960	COG0726	polysaccharide deacetylase
KO64_01020	COG0738	Major facilitator superfamily
KO64_01025	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KO64_01040	COG0659	secondary active sulfate transmembrane transporter activity
KO64_01045	COG0385	Bile acid
KO64_01050	COG2819	hydrolase of the alpha beta superfamily
KO64_01055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KO64_01060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KO64_01065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KO64_01070	COG2207	Transcriptional regulator
KO64_01070	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KO64_01075	COG3876	Protein conserved in bacteria
KO64_01080	COG1472	Belongs to the glycosyl hydrolase 3 family
KO64_01085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KO64_01090	COG1263	PTS System
KO64_01090	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KO64_01100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KO64_01105	COG1683	Conserved Protein
KO64_01135	COG1595	DNA-templated transcription, initiation
KO64_01140	COG5662	AntiSigma factor
KO64_01145	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KO64_01150	COG4856	YbbR-like protein
KO64_01200	COG2205	protein histidine kinase activity
KO64_01205	COG1136	(ABC) transporter
KO64_01210	COG0577	efflux transmembrane transporter activity
KO64_01215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KO64_01230	COG1346	cytolysis
KO64_01235	COG1380	Effector of murein hydrolase LrgA
KO64_01240	COG1846	Transcriptional regulator
KO64_01245	COG1113	amino acid transport
KO64_01250	COG1011	Hydrolase
KO64_01255	COG4585	Histidine kinase
KO64_01260	COG2197	response regulator
KO64_01265	COG1131	(ABC) transporter
KO64_01305	COG0531	amino acid
KO64_01310	COG0584	glycerophosphoryl diester phosphodiesterase
KO64_01315	COG2271	Major facilitator Superfamily
KO64_01325	COG2368	4-hydroxyphenylacetate
KO64_01335	COG3409	Peptidoglycan-binding domain 1 protein
KO64_01350	COG0371	Dehydrogenase
KO64_01360	COG1183	phosphatidylcholine synthase activity
KO64_01365	COG0586	Pfam SNARE associated Golgi protein
KO64_01370	COG0688	phosphatidylethanolamine metabolic process
KO64_01385	COG1301	dicarboxylic acid transport
KO64_01390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KO64_01395	COG0833	amino acid
KO64_01400	COG2040	homocysteine
KO64_01405	COG1115	amino acid carrier protein
KO64_01410	COG2066	Belongs to the glutaminase family
KO64_01415	COG4191	Histidine kinase
KO64_01420	COG0784	Response regulator, receiver
KO64_01435	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KO64_01440	COG0778	Nitroreductase
KO64_01445	COG0346	lactoylglutathione lyase activity
KO64_01450	COG2259	Doxx family
KO64_01455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KO64_01465	COG3773	Cell wall hydrolase
KO64_01470	COG3540	Alkaline phosphatase
KO64_01475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KO64_01480	COG0805	protein transport
KO64_01490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KO64_01495	COG0477	Major facilitator Superfamily
KO64_01500	COG1309	transcriptional regulator
KO64_01505	COG0252	asparaginase activity
KO64_01510	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
KO64_01515	COG1405	negative regulation of cell septum assembly
KO64_01515	COG3012	SEC-C Motif Domain Protein
KO64_01520	COG0667	Aldo Keto reductase
KO64_01530	COG1595	DNA-templated transcription, initiation
KO64_01535	COG1595	DNA-templated transcription, initiation
KO64_01540	COG1876	peptidase activity
KO64_01545	COG0457	Tetratricopeptide repeat
KO64_01550	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_01555	COG0366	Alpha amylase catalytic
KO64_01560	COG0803	Belongs to the bacterial solute-binding protein 9 family
KO64_01565	COG1121	(ABC) transporter
KO64_01570	COG1108	ABC-type Mn2 Zn2 transport systems permease components
KO64_01575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KO64_01580	COG2310	stress, protein
KO64_01585	COG2310	stress, protein
KO64_01590	COG2310	stress, protein
KO64_01595	COG0861	Integral membrane protein TerC family
KO64_01605	COG3853	Toxic anion resistance protein (TelA)
KO64_01610	COG0477	Major facilitator Superfamily
KO64_01615	COG0517	IMP dehydrogenase activity
KO64_01615	COG4175	Glycine betaine
KO64_01620	COG4176	ABC-type proline glycine betaine transport system permease component
KO64_01625	COG2113	Glycine betaine
KO64_01630	COG1473	amidohydrolase
KO64_01635	COG1288	antiporter activity
KO64_01645	COG0366	Alpha amylase catalytic
KO64_01655	COG2814	Major facilitator Superfamily
KO64_01660	COG1846	Transcriptional regulator
KO64_01665	COG1280	lysine exporter protein (LysE YggA)
KO64_01670	COG3403	YqcI/YcgG family
KO64_01675	COG1113	amino acid transport
KO64_01680	COG3665	Urea carboxylase-associated protein
KO64_01695	COG1660	Displays ATPase and GTPase activities
KO64_01700	COG1082	Xylose isomerase domain protein TIM barrel
KO64_01705	COG2271	Major facilitator Superfamily
KO64_01710	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
KO64_01720	COG2801	Transposase and inactivated derivatives
KO64_01725	COG3458	cephalosporin-C deacetylase activity
KO64_01730	COG3541	Predicted nucleotidyltransferase
KO64_01735	COG0506	proline dehydrogenase activity
KO64_01740	COG1012	belongs to the aldehyde dehydrogenase family
KO64_01745	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KO64_01750	COG2508	Transcriptional regulator
KO64_01760	COG1587	Uroporphyrinogen-III synthase
KO64_01760	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KO64_01765	COG2146	nitrite reductase [NAD(P)H] activity
KO64_01770	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KO64_01775	COG0243	molybdopterin cofactor binding
KO64_01780	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
KO64_01785	COG2223	nitrite transmembrane transporter activity
KO64_01790	COG0523	cobalamin synthesis protein
KO64_01795	COG1063	alcohol dehydrogenase
KO64_01800	COG1714	RDD family
KO64_01810	COG2723	6-phospho-beta-galactosidase activity
KO64_01820	COG3209	COG3209 Rhs family protein
KO64_01825	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
KO64_01830	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
KO64_01835	COG1733	regulation of RNA biosynthetic process
KO64_01845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KO64_01850	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KO64_01855	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KO64_01860	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
KO64_01875	COG0697	spore germination
KO64_01880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KO64_01890	COG2364	Membrane
KO64_01895	COG1126	abc transporter atp-binding protein
KO64_01900	COG0765	amino acid transport
KO64_01905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KO64_01910	COG0583	DNA-binding transcription factor activity
KO64_01915	COG0163	prenyltransferase activity
KO64_01920	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
KO64_01935	COG3104	oligopeptide transport
KO64_01940	COG5434	Belongs to the glycosyl hydrolase 28 family
KO64_01950	COG0697	spore germination
KO64_01960	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KO64_01975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KO64_01980	COG0765	amino acid transport
KO64_01985	COG1126	abc transporter atp-binding protein
KO64_01995	COG2079	MmgE PrpD family protein
KO64_02000	COG1136	(ABC) transporter
KO64_02005	COG0577	efflux transmembrane transporter activity
KO64_02010	COG0745	RESPONSE REGULATOR receiver
KO64_02015	COG5002	protein histidine kinase activity
KO64_02015	COG3850	Histidine kinase
KO64_02020	COG0457	Tetratricopeptide repeat
KO64_02035	COG0527	aspartate kinase activity
KO64_02040	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KO64_02045	COG4605	iron ion homeostasis
KO64_02050	COG4604	ABC transporter, ATP-binding protein
KO64_02055	COG4607	ABC-type enterochelin transport system periplasmic component
KO64_02060	COG2814	Major facilitator Superfamily
KO64_02065	COG1309	transcriptional regulator
KO64_02070	COG0778	Nitroreductase
KO64_02075	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
KO64_02080	COG0640	Transcriptional regulator
KO64_02085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KO64_02090	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
KO64_02095	COG1012	belongs to the aldehyde dehydrogenase family
KO64_02100	COG4975	Glucose uptake
KO64_02105	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_02110	COG4549	nuclear export factor GLE1
KO64_02115	COG1276	copper resistance
KO64_02115	COG2372	response to copper ion
KO64_02120	COG1349	DNA-binding transcription factor activity
KO64_02130	COG2213	PTS system mannitol-specific
KO64_02135	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
KO64_02145	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
KO64_02155	COG0561	phosphatase activity
KO64_02165	COG1914	H( )-stimulated, divalent metal cation uptake system
KO64_02175	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
KO64_02180	COG1984	allophanate hydrolase subunit 2
KO64_02185	COG1414	Transcriptional regulator
KO64_02190	COG2755	lipolytic protein G-D-S-L family
KO64_02200	COG2329	Antibiotic biosynthesis monooxygenase
KO64_02205	COG0768	penicillin binding
KO64_02210	COG4989	oxidoreductase activity
KO64_02215	COG3711	transcriptional antiterminator
KO64_02220	COG0318	PFAM AMP-dependent synthetase and ligase
KO64_02225	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_02230	COG1917	Cupin 2, conserved barrel domain protein
KO64_02235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KO64_02240	COG3871	stress protein (general stress protein 26)
KO64_02255	COG2801	Transposase and inactivated derivatives
KO64_02260	COG2814	Major facilitator Superfamily
KO64_02265	COG1522	sequence-specific DNA binding
KO64_02270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KO64_02270	COG0551	DNA topoisomerase type I activity
KO64_02275	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
KO64_02280	COG3706	GGDEF domain
KO64_02285	COG5298	Protein conserved in bacteria
KO64_02290	COG1215	transferase activity, transferring glycosyl groups
KO64_02300	COG0531	amino acid
KO64_02305	COG0494	nUDIX hydrolase
KO64_02310	COG0028	Belongs to the TPP enzyme family
KO64_02335	COG1794	racemase activity, acting on amino acids and derivatives
KO64_02365	COG1914	H( )-stimulated, divalent metal cation uptake system
KO64_02380	COG4876	unkown
KO64_02390	COG2076	Multidrug Resistance protein
KO64_02395	COG2217	Heavy metal translocating P-type atpase
KO64_02400	COG3729	General stress protein
KO64_02405	COG0662	Cupin 2, conserved barrel domain protein
KO64_02410	COG2329	Antibiotic biosynthesis monooxygenase
KO64_02415	COG3546	catalase activity
KO64_02420	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
KO64_02425	COG3290	protein histidine kinase activity
KO64_02430	COG4565	transcriptional regulatory protein
KO64_02435	COG1301	dicarboxylic acid transport
KO64_02440	COG0628	permease
KO64_02445	COG1131	(ABC) transporter
KO64_02450	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KO64_02460	COG1960	acyl-CoA dehydrogenase activity
KO64_02475	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KO64_02480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KO64_02490	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
KO64_02495	COG0513	Belongs to the DEAD box helicase family
KO64_02500	COG3402	PFAM membrane-flanked domain
KO64_02505	COG3428	Bacterial PH domain
KO64_02510	COG0705	Rhomboid family
KO64_02520	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
KO64_02525	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KO64_02530	COG0864	Transcriptional regulator
KO64_02535	COG2337	Toxic component of a toxin-antitoxin (TA) module
KO64_02540	COG1366	Belongs to the anti-sigma-factor antagonist family
KO64_02545	COG1366	Belongs to the anti-sigma-factor antagonist family
KO64_02550	COG2172	sigma factor antagonist activity
KO64_02555	COG2208	phosphoserine phosphatase activity
KO64_02560	COG1366	Belongs to the anti-sigma-factor antagonist family
KO64_02570	COG1191	sigma factor activity
KO64_02575	COG2208	phosphoserine phosphatase activity
KO64_02580	COG2183	response to ionizing radiation
KO64_02650	COG1959	2 iron, 2 sulfur cluster binding
KO64_02655	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KO64_02660	COG2249	NAD(P)H dehydrogenase (quinone) activity
KO64_02670	COG0477	Major facilitator Superfamily
KO64_02685	COG2030	dehydratase
KO64_02695	COG1959	2 iron, 2 sulfur cluster binding
KO64_02700	COG2910	NAD(P)H-binding
KO64_02705	COG1309	transcriptional regulator
KO64_02710	COG0300	oxidoreductase activity
KO64_02720	COG3239	Fatty acid desaturase
KO64_02725	COG1278	Cold shock
KO64_02730	COG1329	Transcriptional regulator
KO64_02735	COG1794	racemase activity, acting on amino acids and derivatives
KO64_02750	COG1846	Transcriptional regulator
KO64_02750	COG0456	acetyltransferase
KO64_02755	COG2271	Major facilitator Superfamily
KO64_02760	COG3621	Patatin-like phospholipase
KO64_02770	COG0662	Cupin 2, conserved barrel domain protein
KO64_02785	COG0277	FAD linked oxidase domain protein
KO64_02810	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
KO64_02845	COG0351	phosphomethylpyrimidine kinase
KO64_02855	COG2801	Transposase and inactivated derivatives
KO64_02870	COG1064	alcohol dehydrogenase
KO64_02875	COG0789	Transcriptional regulator
KO64_02885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KO64_02900	COG2814	Major facilitator Superfamily
KO64_02905	COG1309	transcriptional regulator
KO64_02910	COG0697	spore germination
KO64_02915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KO64_02920	COG5577	PFAM Coat F domain
KO64_02930	COG1063	alcohol dehydrogenase
KO64_02935	COG5577	PFAM Coat F domain
KO64_02950	COG4585	Histidine kinase
KO64_02955	COG2197	response regulator
KO64_02960	COG2409	Drug exporters of the RND superfamily
KO64_02965	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
KO64_02975	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KO64_02980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KO64_02990	COG2814	Major facilitator Superfamily
KO64_02995	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KO64_03005	COG0730	response to heat
KO64_03010	COG0456	acetyltransferase
KO64_03015	COG0789	Transcriptional regulator
KO64_03015	COG4978	Transcriptional regulator
KO64_03020	COG0697	spore germination
KO64_03025	COG1051	belongs to the nudix hydrolase family
KO64_03030	COG2226	methyltransferase
KO64_03035	COG0473	3-isopropylmalate dehydrogenase activity
KO64_03040	COG1802	Transcriptional regulator
KO64_03045	COG1819	glycosyl
KO64_03060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KO64_03065	COG1388	LysM domain
KO64_03070	COG2814	Major facilitator Superfamily
KO64_03075	COG2188	Transcriptional regulator
KO64_03080	COG2186	Transcriptional regulator
KO64_03085	COG2807	transmembrane transport
KO64_03090	COG2076	Multidrug Resistance protein
KO64_03095	COG2076	Multidrug Resistance protein
KO64_03100	COG1309	transcriptional regulator
KO64_03105	COG0531	amino acid
KO64_03115	COG3832	glyoxalase III activity
KO64_03120	COG0604	alcohol dehydrogenase
KO64_03125	COG2814	Major facilitator Superfamily
KO64_03165	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
KO64_03170	COG0802	atpase or kinase
KO64_03175	COG1214	PFAM Peptidase M22, glycoprotease
KO64_03180	COG0456	acetyltransferase
KO64_03185	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
KO64_03190	COG0488	(ABC) transporter
KO64_03205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
KO64_03210	COG0805	protein transport
KO64_03220	COG1266	CAAX protease self-immunity
KO64_03225	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
KO64_03235	COG3409	Peptidoglycan-binding domain 1 protein
KO64_03255	COG1063	alcohol dehydrogenase
KO64_03260	COG2211	Major facilitator Superfamily
KO64_03265	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KO64_03275	COG1842	Phage shock protein A
KO64_03280	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KO64_03285	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
KO64_03290	COG4260	virion core protein, lumpy skin disease virus
KO64_03295	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
KO64_03295	COG2755	lipolytic protein G-D-S-L family
KO64_03305	COG1595	DNA-templated transcription, initiation
KO64_03310	COG1063	alcohol dehydrogenase
KO64_03315	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
KO64_03320	COG0823	Involved in the tonB-independent uptake of proteins
KO64_03335	COG2132	Multicopper oxidase
KO64_03340	COG1113	amino acid transport
KO64_03345	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KO64_03350	COG0714	Associated with various cellular activities
KO64_03355	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
KO64_03360	COG1305	Transglutaminase-like
KO64_03385	COG2252	PERMEase
KO64_03390	COG3064	Membrane
KO64_03410	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
KO64_03415	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
KO64_03420	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
KO64_03425	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
KO64_03430	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
KO64_03445	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
KO64_03455	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
KO64_03460	COG0138	bifunctional purine biosynthesis protein purh
KO64_03465	COG0151	Belongs to the GarS family
KO64_03475	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
KO64_03480	COG1470	cell adhesion involved in biofilm formation
KO64_03485	COG4496	protein, YerC YecD
KO64_03490	COG0069	glutamate synthase activity
KO64_03505	COG0210	DNA helicase
KO64_03515	COG4851	CamS sex pheromone cAM373 precursor
KO64_03520	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KO64_03525	COG1285	pathogenesis
KO64_03530	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KO64_03550	COG1309	transcriptional regulator
KO64_03555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
KO64_03560	COG1597	lipid kinase activity
KO64_03565	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KO64_03570	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
KO64_03580	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
KO64_03615	COG5444	nuclease activity
KO64_03645	COG3546	catalase activity
KO64_03650	COG0454	-acetyltransferase
KO64_03660	COG2323	membrane
KO64_03665	COG2329	Antibiotic biosynthesis monooxygenase
KO64_03670	COG0346	lactoylglutathione lyase activity
KO64_03675	COG1366	Belongs to the anti-sigma-factor antagonist family
KO64_03680	COG5583	Uncharacterized small protein (DUF2292)
KO64_03685	COG0196	riboflavin kinase activity
KO64_03690	COG0670	Belongs to the BI1 family
KO64_03695	COG1846	Transcriptional regulator
KO64_03700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KO64_03710	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KO64_03710	COG2124	cytochrome p450
KO64_03715	COG1368	sulfuric ester hydrolase activity
KO64_03720	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
KO64_03725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KO64_03730	COG1442	glycosyl transferase family 8
KO64_03735	COG1216	Glycosyl transferase, family 2
KO64_03740	COG1442	glycosyl transferase family 8
KO64_03745	COG2223	nitrite transmembrane transporter activity
KO64_03750	COG0531	amino acid
KO64_03755	COG1012	belongs to the aldehyde dehydrogenase family
KO64_03760	COG0840	transmembrane signaling receptor activity
KO64_03765	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_03770	COG0457	Tetratricopeptide repeat
KO64_03770	COG0463	Glycosyl transferase, family 2
KO64_03775	COG0488	(ABC) transporter
KO64_03780	COG0789	Transcriptional regulator
KO64_03785	COG2814	Major facilitator Superfamily
KO64_03790	COG0488	(ABC) transporter
KO64_03795	COG0513	Belongs to the DEAD box helicase family
KO64_03800	COG0456	acetyltransferase
KO64_03805	COG2130	NADP-dependent
KO64_03820	COG3866	Pectate lyase
KO64_03825	COG0471	metal ion transport
KO64_03850	COG3290	protein histidine kinase activity
KO64_03855	COG4565	transcriptional regulatory protein
KO64_03860	COG3181	Tripartite tricarboxylate transporter family receptor
KO64_03865	COG2851	Citrate transporter
KO64_03870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KO64_03875	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
KO64_03885	COG2258	MOSC domain
KO64_03905	COG0024	Methionine aminopeptidase
KO64_03910	COG1263	PTS System
KO64_03910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KO64_03920	COG1368	sulfuric ester hydrolase activity
KO64_03930	COG0071	Belongs to the small heat shock protein (HSP20) family
KO64_03945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KO64_03945	COG1263	PTS System
KO64_03950	COG0366	Alpha amylase catalytic
KO64_03955	COG2188	Transcriptional regulator
KO64_03960	COG0778	Nitroreductase
KO64_03975	COG0737	Belongs to the 5'-nucleotidase family
KO64_03980	COG0693	protein deglycase activity
KO64_03985	COG1609	Transcriptional regulator
KO64_03990	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KO64_04000	COG2814	Major facilitator Superfamily
KO64_04010	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KO64_04015	COG4980	gas vesicle protein
KO64_04020	COG1295	ribonuclease BN
KO64_04030	COG0477	Major facilitator Superfamily
KO64_04035	COG0387	Pfam Sodium calcium exchanger
KO64_04045	COG0668	transmembrane transport
KO64_04050	COG0535	radical SAM domain protein
KO64_04060	COG0726	polysaccharide deacetylase
KO64_04065	COG2084	Dehydrogenase
KO64_04075	COG0598	Magnesium transport protein CorA
KO64_04080	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
KO64_04085	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
KO64_04095	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
KO64_04100	COG4637	Psort location Cytoplasmic, score
KO64_04105	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KO64_04110	COG0022	dehydrogenase e1 component
KO64_04115	COG0508	dehydrogenase complex catalyzes the overall conversion of
KO64_04120	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KO64_04125	COG3284	Transcriptional regulator
KO64_04135	COG1486	melibiose metabolic process
KO64_04140	COG1737	Transcriptional regulator
KO64_04145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KO64_04145	COG1263	PTS System
KO64_04150	COG1132	(ABC) transporter
KO64_04155	COG1132	(ABC) transporter
KO64_04160	COG2259	Doxx family
KO64_04165	COG2514	catechol 2,3-dioxygenase activity
KO64_04180	COG1695	Transcriptional regulator
KO64_04185	COG2249	NAD(P)H dehydrogenase (quinone) activity
KO64_04190	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
KO64_04195	COG3848	Pyruvate phosphate dikinase
KO64_04195	COG0574	Belongs to the PEP-utilizing enzyme family
KO64_04200	COG2732	(Barnase) inhibitor
KO64_04205	COG2318	DinB family
KO64_04210	COG2814	Major facilitator Superfamily
KO64_04215	COG1846	Transcriptional regulator
KO64_04220	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
KO64_04220	COG0392	lysyltransferase activity
KO64_04225	COG0384	phenazine biosynthesis protein PhzF
KO64_04230	COG0778	Nitroreductase
KO64_04245	COG1090	epimerase
KO64_04260	COG2814	Major facilitator Superfamily
KO64_04270	COG3591	Belongs to the peptidase S1B family
KO64_04285	COG3103	Sh3 type 3 domain protein
KO64_04290	COG5658	integral membrane protein
KO64_04295	COG0596	Alpha beta hydrolase
KO64_04300	COG0463	Glycosyl transferase, family 2
KO64_04305	COG4485	Bacterial membrane protein, YfhO
KO64_04310	COG1988	membrane-bound metal-dependent
KO64_04315	COG1194	a g-specific adenine glycosylase
KO64_04325	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_04345	COG1132	(ABC) transporter
KO64_04350	COG4129	membrane
KO64_04365	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
KO64_04370	COG0735	belongs to the Fur family
KO64_04480	COG1757	Na H antiporter
KO64_04495	COG0277	FAD linked oxidase domain protein
KO64_04505	COG0747	negative chemotaxis
KO64_04510	COG0601	transmembrane transport
KO64_04515	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KO64_04520	COG0444	Belongs to the ABC transporter superfamily
KO64_04525	COG4608	Belongs to the ABC transporter superfamily
KO64_04530	COG0753	catalase activity
KO64_04540	COG1116	anion transmembrane transporter activity
KO64_04545	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KO64_04550	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KO64_04570	COG1476	TRANSCRIPTIONal
KO64_04580	COG3382	B3 4 domain protein
KO64_04585	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
KO64_04595	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
KO64_04600	COG0789	Transcriptional regulator
KO64_04605	COG1664	Polymer-forming cytoskeletal
KO64_04610	COG1664	Polymer-forming cytoskeletal
KO64_04615	COG2766	serine protein kinase
KO64_04625	COG1846	Transcriptional regulator
KO64_04630	COG1566	PFAM secretion protein HlyD family protein
KO64_04635	COG2814	Major facilitator Superfamily
KO64_04640	COG0655	NAD(P)H dehydrogenase (quinone) activity
KO64_04655	COG1725	Transcriptional regulator
KO64_04660	COG1131	(ABC) transporter
KO64_04665	COG1131	(ABC) transporter
KO64_04670	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KO64_04675	COG1278	Cold shock
KO64_04680	COG1464	Belongs to the NlpA lipoprotein family
KO64_04685	COG3706	GGDEF domain
KO64_04690	COG1823	symporter activity
KO64_04710	COG5577	PFAM Coat F domain
KO64_04720	COG3764	Sortase (surface protein transpeptidase)
KO64_04725	COG0564	pseudouridine synthase activity
KO64_04735	COG0517	IMP dehydrogenase activity
KO64_04740	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
KO64_04745	COG3153	acetyltransferase
KO64_04745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KO64_04750	COG2801	Transposase and inactivated derivatives
KO64_04760	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KO64_04765	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
KO64_04770	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
KO64_04780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
KO64_04785	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
KO64_04790	COG4585	Histidine kinase
KO64_04790	COG2203	Gaf domain
KO64_04795	COG2197	response regulator
KO64_04800	COG0431	NADPH-dependent FMN reductase
KO64_04815	COG0791	NLP P60 protein
KO64_04815	COG1388	LysM domain
KO64_04820	COG1959	2 iron, 2 sulfur cluster binding
KO64_04825	COG0668	transmembrane transport
KO64_04830	COG2719	SpoVR family
KO64_04835	COG1785	Belongs to the alkaline phosphatase family
KO64_04840	COG0791	NLP P60 protein
KO64_04840	COG1388	LysM domain
KO64_04845	COG0583	DNA-binding transcription factor activity
KO64_04850	COG0372	Belongs to the citrate synthase family
KO64_04855	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_04860	COG0531	amino acid
KO64_04865	COG0733	neurotransmitter:sodium symporter activity
KO64_04880	COG1595	DNA-templated transcription, initiation
KO64_04885	COG0204	Acyl-transferase
KO64_04890	COG1253	flavin adenine dinucleotide binding
KO64_04895	COG0789	Transcriptional regulator
KO64_04900	COG0436	Aminotransferase
KO64_04905	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KO64_04910	COG1253	flavin adenine dinucleotide binding
KO64_04915	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KO64_04920	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
KO64_04925	COG0584	glycerophosphoryl diester phosphodiesterase
KO64_04935	COG0668	transmembrane transport
KO64_04940	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
KO64_04945	COG0726	polysaccharide deacetylase
KO64_04950	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KO64_04955	COG3226	Transcriptional regulator
KO64_04965	COG0589	response to stress
KO64_04970	COG1132	(ABC) transporter
KO64_04975	COG1132	(ABC) transporter
KO64_04980	COG0702	epimerase
KO64_04995	COG0189	ligase activity
KO64_05000	COG0189	ligase activity
KO64_05015	COG4335	DNA alkylation repair
KO64_05020	COG0561	phosphatase activity
KO64_05025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KO64_05035	COG0475	glutathione-regulated potassium exporter activity
KO64_05040	COG0490	domain, Protein
KO64_05050	COG1024	Enoyl-CoA hydratase
KO64_05060	COG4152	abc transporter atp-binding protein
KO64_05065	COG1668	transmembrane transport
KO64_05070	COG0420	3'-5' exonuclease activity
KO64_05075	COG4717	serine-type aminopeptidase activity
KO64_05090	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
KO64_05125	COG4980	gas vesicle protein
KO64_05140	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
KO64_05145	COG0537	adenosine 5'-monophosphoramidase activity
KO64_05150	COG1131	(ABC) transporter
KO64_05155	COG4473	ABC transporter
KO64_05165	COG1473	amidohydrolase
KO64_05170	COG3069	C4-dicarboxylate transmembrane transporter activity
KO64_05175	COG2329	Antibiotic biosynthesis monooxygenase
KO64_05180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KO64_05200	COG1309	transcriptional regulator
KO64_05205	COG1511	domain protein
KO64_05210	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KO64_05220	COG1363	Peptidase, m42
KO64_05225	COG1301	dicarboxylic acid transport
KO64_05235	COG1234	tRNA 3'-trailer cleavage
KO64_05240	COG0095	Lipoate-protein ligase
KO64_05245	COG0702	epimerase
KO64_05250	COG0318	PFAM AMP-dependent synthetase and ligase
KO64_05260	COG0501	Belongs to the peptidase M48B family
KO64_05265	COG1404	Belongs to the peptidase S8 family
KO64_05275	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
KO64_05280	COG0406	alpha-ribazole phosphatase activity
KO64_05285	COG0183	Belongs to the thiolase family
KO64_05290	COG0318	PFAM AMP-dependent synthetase and ligase
KO64_05295	COG1268	BioY protein
KO64_05300	COG0840	transmembrane signaling receptor activity
KO64_05305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KO64_05305	COG0723	plastoquinol--plastocyanin reductase activity
KO64_05310	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_05320	COG4903	ComK protein
KO64_05330	COG5646	InterPro IPR014922
KO64_05355	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KO64_05370	COG0398	Pfam SNARE associated Golgi protein
KO64_05375	COG0681	Belongs to the peptidase S26 family
KO64_05380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
KO64_05385	COG1846	Transcriptional regulator
KO64_05390	COG3180	Ammonia monooxygenase
KO64_05395	COG2814	Major facilitator Superfamily
KO64_05405	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
KO64_05410	COG2323	membrane
KO64_05425	COG0420	3'-5' exonuclease activity
KO64_05430	COG0419	ATPase involved in DNA repair
KO64_05435	COG1403	HNH endonuclease
KO64_05475	COG0179	Fumarylacetoacetate (FAA) hydrolase
KO64_05495	COG0367	asparagine synthase
KO64_05500	COG1562	ergosterol biosynthetic process
KO64_05505	COG0534	Mate efflux family protein
KO64_05510	COG2207	Transcriptional regulator
KO64_05510	COG1917	Cupin 2, conserved barrel domain protein
KO64_05515	COG2318	DinB family
KO64_05520	COG1357	PFAM Pentapeptide repeats (8 copies)
KO64_05525	COG2153	protein acetylation
KO64_05530	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
KO64_05530	COG0646	methionine synthase
KO64_05540	COG2996	Protein conserved in bacteria
KO64_05550	COG0840	transmembrane signaling receptor activity
KO64_05555	COG2124	cytochrome p450
KO64_05560	COG1307	EDD domain protein, DegV family
KO64_05565	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KO64_05585	COG0561	phosphatase activity
KO64_05590	COG1073	alpha beta
KO64_05595	COG2151	metal-sulfur cluster biosynthetic enzyme
KO64_05605	COG0277	FAD linked oxidase domain protein
KO64_05610	COG2271	Major facilitator Superfamily
KO64_05630	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KO64_05635	COG0505	Belongs to the CarA family
KO64_05640	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KO64_05645	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
KO64_05660	COG2267	carboxylic ester hydrolase activity
KO64_05670	COG1744	ABC transporter substrate-binding protein PnrA-like
KO64_05685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KO64_05690	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
KO64_05695	COG5504	Zn-dependent protease
KO64_05700	COG0444	Belongs to the ABC transporter superfamily
KO64_05705	COG4608	Belongs to the ABC transporter superfamily
KO64_05715	COG0601	transmembrane transport
KO64_05720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KO64_05730	COG0180	Tryptophanyl-tRNA synthetase
KO64_05735	COG4166	transmembrane transport
KO64_05740	COG0601	transmembrane transport
KO64_05745	COG0861	Integral membrane protein TerC family
KO64_05750	COG4862	establishment of competence for transformation
KO64_05755	COG4469	Competence protein
KO64_05760	COG1164	Oligoendopeptidase f
KO64_05780	COG2346	COG2346, Truncated hemoglobins
KO64_05785	COG0741	lytic transglycosylase activity
KO64_05790	COG4116	CYTH
KO64_05800	COG2357	RelA SpoT domain protein
KO64_05805	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KO64_05810	COG0564	pseudouridine synthase activity
KO64_05820	COG0475	glutathione-regulated potassium exporter activity
KO64_05820	COG0569	domain protein
KO64_05825	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
KO64_05830	COG0352	thiamine-phosphate diphosphorylase activity
KO64_05835	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KO64_05840	COG2104	thiamine diphosphate biosynthetic process
KO64_05850	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KO64_05855	COG0351	phosphomethylpyrimidine kinase
KO64_05860	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
KO64_05920	COG0210	DNA helicase
KO64_05940	COG1131	(ABC) transporter
KO64_05950	COG2153	protein acetylation
KO64_05960	COG2382	esterase
KO64_05965	COG0626	cystathionine gamma-synthase activity
KO64_05970	COG0626	cystathionine gamma-synthase activity
KO64_05985	COG5444	nuclease activity
KO64_06005	COG0346	lactoylglutathione lyase activity
KO64_06010	COG2367	Beta-lactamase
KO64_06015	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
KO64_06025	COG1846	Transcriptional regulator
KO64_06035	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
KO64_06040	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KO64_06045	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KO64_06050	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KO64_06050	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KO64_06055	COG1447	Phosphotransferase system cellobiose-specific component IIA
KO64_06090	COG1285	pathogenesis
KO64_06105	COG2205	protein histidine kinase activity
KO64_06115	COG3383	formate dehydrogenase (NAD+) activity
KO64_06120	COG2427	Protein of unknown function (DUF1641)
KO64_06125	COG2124	cytochrome p450
KO64_06130	COG1819	glycosyl
KO64_06140	COG1587	Uroporphyrinogen-III synthase
KO64_06145	COG0390	transport system, permease component
KO64_06150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KO64_06155	COG0697	spore germination
KO64_06160	COG4297	protein containing double-stranded beta helix domain
KO64_06170	COG1252	NADH dehydrogenase
KO64_06180	COG2211	Major facilitator Superfamily
KO64_06185	COG1609	Transcriptional regulator
KO64_06190	COG0246	Mannitol dehydrogenase
KO64_06195	COG2721	sulfolactate sulfo-lyase activity
KO64_06200	COG0730	response to heat
KO64_06205	COG2318	DinB family
KO64_06210	COG0457	Tetratricopeptide repeat
KO64_06220	COG5632	N-Acetylmuramoyl-L-alanine amidase
KO64_06220	COG3409	Peptidoglycan-binding domain 1 protein
KO64_06220	COG1388	LysM domain
KO64_06230	COG4195	phage-related replication protein
KO64_06235	COG2856	Zn peptidase
KO64_06240	COG1396	sequence-specific DNA binding
KO64_06250	COG1522	sequence-specific DNA binding
KO64_06255	COG1484	DNA-dependent DNA replication
KO64_06275	COG1595	DNA-templated transcription, initiation
KO64_06280	COG3728	DNA packaging
KO64_06280	COG5484	DNA packaging
KO64_06285	COG1783	phage Terminase large subunit
KO64_06290	COG5518	Phage portal protein
KO64_06295	COG0338	D12 class N6 adenine-specific DNA methyltransferase
KO64_06300	COG4653	Phage capsid family
KO64_06350	COG5412	phage tail tape measure protein
KO64_06350	COG5412	phage tail tape measure protein
KO64_06350	COG5412	phage tail tape measure protein
KO64_06350	COG3953	SLT domain
KO64_06350	COG3953	SLT domain
KO64_06350	COG3953	SLT domain
KO64_06355	COG1652	LysM domain
KO64_06360	COG4193	domain, Protein
KO64_06370	COG3628	GPW Gp25 family protein
KO64_06375	COG3299	homolog of phage Mu protein gp47
KO64_06380	COG3778	Protein conserved in bacteria
KO64_06420	COG5632	N-Acetylmuramoyl-L-alanine amidase
KO64_06420	COG3409	Peptidoglycan-binding domain 1 protein
KO64_06435	COG0306	phosphate transporter
KO64_06440	COG1392	Phosphate transport regulator
KO64_06445	COG0531	amino acid
KO64_06450	COG0346	lactoylglutathione lyase activity
KO64_06455	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KO64_06460	COG0463	Glycosyl transferase, family 2
KO64_06465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KO64_06470	COG0477	Major facilitator Superfamily
KO64_06475	COG2362	D-Aminopeptidase
KO64_06480	COG0601	transmembrane transport
KO64_06485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
KO64_06490	COG0444	Belongs to the ABC transporter superfamily
KO64_06495	COG4166	transmembrane transport
KO64_06500	COG1619	proteins homologs of microcin C7 resistance protein MccF
KO64_06505	COG4948	Mandelate Racemase Muconate Lactonizing
KO64_06510	COG0791	NLP P60 protein
KO64_06515	COG4608	Belongs to the ABC transporter superfamily
KO64_06520	COG2706	6-phosphogluconolactonase activity
KO64_06525	COG1834	amidinotransferase
KO64_06530	COG1607	acyl-coa hydrolase
KO64_06535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KO64_06540	COG2076	Multidrug Resistance protein
KO64_06545	COG2076	Multidrug Resistance protein
KO64_06550	COG0788	formyltetrahydrofolate deformylase activity
KO64_06555	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KO64_06565	COG1764	response to oxidative stress
KO64_06570	COG1846	Transcriptional regulator
KO64_06575	COG1764	response to oxidative stress
KO64_06590	COG0463	Glycosyl transferase, family 2
KO64_06590	COG0457	Tetratricopeptide repeat
KO64_06600	COG2814	Major facilitator Superfamily
KO64_06605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KO64_06615	COG1404	Belongs to the peptidase S8 family
KO64_06620	COG1366	Belongs to the anti-sigma-factor antagonist family
KO64_06625	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
KO64_06630	COG1122	ATPase activity
KO64_06635	COG4721	ABC-type cobalt transport system, permease component
KO64_06640	COG1388	LysM domain
KO64_06640	COG3858	chitin binding
KO64_06655	COG2239	Acts as a magnesium transporter
KO64_06660	COG0789	Transcriptional regulator
KO64_06675	COG1846	Transcriptional regulator
KO64_06680	COG0726	polysaccharide deacetylase
KO64_06685	COG1793	dna ligase
KO64_06685	COG3285	dna ligase
KO64_06690	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
KO64_06695	COG0586	Pfam SNARE associated Golgi protein
KO64_06700	COG0861	Integral membrane protein TerC family
KO64_06705	COG1191	sigma factor activity
KO64_06730	COG2801	Transposase and inactivated derivatives
KO64_06740	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
KO64_06760	COG3594	Acyltransferase
KO64_06765	COG5002	protein histidine kinase activity
KO64_06770	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KO64_06785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
KO64_06790	COG0436	Aminotransferase
KO64_06820	COG3852	Histidine kinase
KO64_06825	COG1846	Transcriptional regulator
KO64_06830	COG1360	Flagellar Motor Protein
KO64_06835	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KO64_06840	COG0542	response to heat
KO64_06850	COG3949	Membrane
KO64_06865	COG0720	synthase
KO64_06870	COG0602	queuosine metabolic process
KO64_06880	COG1733	regulation of RNA biosynthetic process
KO64_06885	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_06895	COG1388	LysM domain
KO64_06895	COG4641	Protein conserved in bacteria
KO64_06900	COG1388	LysM domain
KO64_06905	COG3858	chitin binding
KO64_06915	COG4873	Protein conserved in bacteria
KO64_06925	COG3773	Cell wall hydrolase
KO64_06930	COG2244	polysaccharide biosynthetic process
KO64_06935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KO64_06940	COG2217	Heavy metal translocating P-type atpase
KO64_06945	COG0006	proline dipeptidase activity
KO64_06955	COG1609	Transcriptional regulator
KO64_06960	COG3711	transcriptional antiterminator
KO64_06965	COG1263	PTS System
KO64_06965	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KO64_06965	COG2190	(PTS) system
KO64_06970	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KO64_06975	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
KO64_06985	COG1533	DNA photolyase activity
KO64_06990	COG0840	transmembrane signaling receptor activity
KO64_06995	COG2084	Dehydrogenase
KO64_07000	COG2340	Cysteine-rich secretory protein family
KO64_07005	COG0768	penicillin binding
KO64_07010	COG4191	Histidine kinase
KO64_07015	COG0436	Aminotransferase
KO64_07025	COG0835	chemotaxis
KO64_07025	COG0784	Response regulator, receiver
KO64_07035	COG2814	Major facilitator Superfamily
KO64_07040	COG1376	ErfK ybiS ycfS ynhG family protein
KO64_07045	COG1408	metallophosphoesterase
KO64_07050	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_07060	COG2200	EAL domain
KO64_07065	COG4703	Protein of unknown function (DUF1797)
KO64_07070	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
KO64_07080	COG0517	IMP dehydrogenase activity
KO64_07085	COG0583	DNA-binding transcription factor activity
KO64_07090	COG0716	FMN binding
KO64_07100	COG0716	FMN binding
KO64_07120	COG0668	transmembrane transport
KO64_07125	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KO64_07145	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KO64_07150	COG0303	'Molybdopterin
KO64_07155	COG1763	Mo-molybdopterin cofactor biosynthetic process
KO64_07160	COG0314	molybdopterin synthase activity
KO64_07165	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
KO64_07175	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
KO64_07180	COG1136	(ABC) transporter
KO64_07185	COG0577	efflux transmembrane transporter activity
KO64_07190	COG1349	DNA-binding transcription factor activity
KO64_07195	COG1105	Belongs to the carbohydrate kinase PfkB family
KO64_07200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KO64_07200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KO64_07200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KO64_07205	COG0681	Belongs to the peptidase S26 family
KO64_07215	COG0488	(ABC) transporter
KO64_07220	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KO64_07225	COG2309	aminopeptidase activity
KO64_07235	COG1077	Cell shape determining protein MreB Mrl
KO64_07245	COG2002	toxin-antitoxin pair type II binding
KO64_07250	COG3852	Histidine kinase
KO64_07255	COG2105	PFAM AIG2 family protein
KO64_07255	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
KO64_07260	COG0569	domain protein
KO64_07270	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KO64_07280	COG0561	phosphatase activity
KO64_07285	COG0242	peptide deformylase activity
KO64_07295	COG0497	DNA recombination
KO64_07310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KO64_07310	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_07310	COG3321	synthase
KO64_07310	COG4221	oxidoreductase activity
KO64_07315	COG4221	oxidoreductase activity
KO64_07315	COG3321	synthase
KO64_07315	COG0300	oxidoreductase activity
KO64_07315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KO64_07320	COG4221	oxidoreductase activity
KO64_07320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KO64_07320	COG3321	synthase
KO64_07320	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_07325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KO64_07325	COG0300	oxidoreductase activity
KO64_07325	COG0318	PFAM AMP-dependent synthetase and ligase
KO64_07325	COG3321	synthase
KO64_07325	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_07330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KO64_07330	COG0300	oxidoreductase activity
KO64_07330	COG3321	synthase
KO64_07330	COG4221	oxidoreductase activity
KO64_07335	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KO64_07335	COG4221	oxidoreductase activity
KO64_07335	COG3321	synthase
KO64_07335	COG0300	oxidoreductase activity
KO64_07340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KO64_07340	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_07340	COG3321	synthase
KO64_07340	COG4221	oxidoreductase activity
KO64_07345	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KO64_07350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KO64_07355	COG0022	dehydrogenase e1 component
KO64_07360	COG0508	dehydrogenase complex catalyzes the overall conversion of
KO64_07365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KO64_07370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KO64_07380	COG1982	Orn Lys Arg decarboxylase major
KO64_07400	COG0483	inositol monophosphate 1-phosphatase activity
KO64_07410	COG3227	Zinc metalloprotease (Elastase)
KO64_07440	COG4896	Protein conserved in bacteria
KO64_07450	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
KO64_07455	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KO64_07460	COG2066	Belongs to the glutaminase family
KO64_07470	COG0772	Belongs to the SEDS family
KO64_07475	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
KO64_07490	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KO64_07490	COG2010	Cytochrome c
KO64_07495	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KO64_07500	COG1845	cytochrome c oxidase, subunit III
KO64_07505	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
KO64_07510	COG3336	cytochrome c oxidase
KO64_07520	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
KO64_07525	COG2340	Cysteine-rich secretory protein family
KO64_07540	COG3679	Belongs to the UPF0342 family
KO64_07555	COG0742	ribosomal rna small subunit methyltransferase
KO64_07565	COG3314	Sporulation integral membrane protein YlbJ
KO64_07570	COG1752	Esterase of the alpha-beta hydrolase superfamily
KO64_07575	COG3480	Lon protease (S16) C-terminal proteolytic domain
KO64_07585	COG1399	metal-binding, possibly nucleic acid-binding protein
KO64_07590	COG0333	Belongs to the bacterial ribosomal protein bL32 family
KO64_07605	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
KO64_07625	COG4839	cell division protein FtsL
KO64_07635	COG0768	penicillin binding
KO64_07660	COG0772	Belongs to the SEDS family
KO64_07675	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
KO64_07685	COG0849	cell division
KO64_07690	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
KO64_07695	COG1404	Belongs to the peptidase S8 family
KO64_07695	COG4412	M6 family metalloprotease domain protein
KO64_07705	COG1191	sigma factor activity
KO64_07710	COG1191	sigma factor activity
KO64_07715	COG1119	ATPase activity
KO64_07720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KO64_07725	COG1873	PFAM PRC-barrel domain
KO64_07735	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
KO64_07745	COG0762	integral membrane protein
KO64_07750	COG2302	S4 RNA-binding domain
KO64_07755	COG3599	regulation of cell shape
KO64_07765	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
KO64_07770	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KO64_07780	COG0564	pseudouridine synthase activity
KO64_07790	COG2233	PERMEase
KO64_07800	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
KO64_07805	COG0505	Belongs to the CarA family
KO64_07810	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
KO64_07825	COG0284	orotidine-5'-phosphate decarboxylase activity
KO64_07830	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
KO64_07845	COG0306	phosphate transporter
KO64_07860	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
KO64_07865	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
KO64_07870	COG1648	precorrin-2 dehydrogenase activity
KO64_07880	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
KO64_07885	COG1561	YicC-like family, N-terminal region
KO64_07890	COG2052	Domain of unknown function (DUF370)
KO64_07895	COG0194	GDP metabolic process
KO64_07905	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KO64_07910	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
KO64_07915	COG0242	peptide deformylase activity
KO64_07925	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
KO64_07925	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
KO64_07935	COG0631	protein serine/threonine phosphatase activity
KO64_07940	COG0515	serine threonine protein kinase
KO64_07940	COG2815	serine threonine protein kinase
KO64_07950	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
KO64_07955	COG1564	THIamine pyrophosphokinase
KO64_07970	COG1302	Protein conserved in bacteria
KO64_07975	COG1461	Dihydroxyacetone kinase
KO64_07980	COG1760	l-serine dehydratase
KO64_07985	COG1760	l-serine dehydratase
KO64_07990	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
KO64_08005	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KO64_08010	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_08015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KO64_08025	COG1196	nuclear chromosome segregation
KO64_08030	COG0552	protein localization to endoplasmic reticulum
KO64_08045	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
KO64_08055	COG1837	Belongs to the UPF0109 family
KO64_08080	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KO64_08095	COG2257	FlhB HrpN YscU SpaS Family
KO64_08105	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
KO64_08110	COG0758	DNA mediated transformation
KO64_08115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
KO64_08125	COG4974	Belongs to the 'phage' integrase family
KO64_08145	COG1815	bacterial-type flagellum-dependent cell motility
KO64_08150	COG1558	bacterial-type flagellum-dependent cell motility
KO64_08155	COG1677	Flagellar hook-basal body complex protein FliE
KO64_08160	COG1766	The M ring may be actively involved in energy transduction
KO64_08165	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KO64_08170	COG1317	bacterial-type flagellum organization
KO64_08175	COG1157	protein secretion by the type III secretion system
KO64_08180	COG2882	bacterial-type flagellum organization
KO64_08185	COG3334	PFAM MgtE intracellular
KO64_08190	COG3144	bacterial-type flagellum assembly
KO64_08195	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
KO64_08200	COG4786	Flagellar basal body rod
KO64_08205	COG1582	Flagellar protein (FlbD)
KO64_08210	COG1580	Controls the rotational direction of flagella during chemotaxis
KO64_08215	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KO64_08220	COG1776	CheC inhibitor of MCP methylation
KO64_08220	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
KO64_08225	COG2201	protein-glutamate methylesterase activity
KO64_08230	COG3190	flagellar
KO64_08235	COG1338	Plays a role in the flagellum-specific transport system
KO64_08240	COG1987	bacterial-type flagellum assembly
KO64_08245	COG1684	flagellar biosynthetic protein fliR
KO64_08250	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KO64_08255	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
KO64_08260	COG1419	protein localization to endoplasmic reticulum
KO64_08265	COG0455	bacterial-type flagellum organization
KO64_08270	COG2201	protein-glutamate methylesterase activity
KO64_08275	COG2198	Histidine kinase
KO64_08275	COG0643	Histidine kinase
KO64_08280	COG0835	chemotaxis
KO64_08285	COG1776	CheC inhibitor of MCP methylation
KO64_08295	COG1191	sigma factor activity
KO64_08325	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
KO64_08330	COG4589	Belongs to the CDS family
KO64_08340	COG0750	zinc metalloprotease
KO64_08350	COG2176	DNA-directed DNA polymerase activity
KO64_08360	COG0195	Participates in both transcription termination and antitermination
KO64_08365	COG2740	Nucleic-acid-binding protein implicated in transcription termination
KO64_08370	COG1358	cellular component organization or biogenesis
KO64_08380	COG1550	Protein conserved in bacteria
KO64_08395	COG0196	riboflavin kinase activity
KO64_08410	COG0726	polysaccharide deacetylase
KO64_08415	COG0612	Peptidase, M16
KO64_08420	COG1873	PFAM PRC-barrel domain
KO64_08425	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KO64_08430	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
KO64_08435	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
KO64_08440	COG0527	aspartate kinase activity
KO64_08450	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
KO64_08455	COG0740	serine-type endopeptidase activity
KO64_08465	COG1674	ftsk spoiiie
KO64_08465	COG4980	gas vesicle protein
KO64_08470	COG2188	Transcriptional regulator
KO64_08475	COG2814	Major facilitator Superfamily
KO64_08480	COG1846	Transcriptional regulator
KO64_08485	COG1033	growth of symbiont in host cell
KO64_08485	COG2409	Drug exporters of the RND superfamily
KO64_08490	COG0612	Peptidase, M16
KO64_08495	COG0612	Peptidase, M16
KO64_08500	COG0300	oxidoreductase activity
KO64_08515	COG1426	Protein conserved in bacteria
KO64_08520	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
KO64_08535	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
KO64_08545	COG1692	metallophosphoesterase
KO64_08550	COG2359	stage V sporulation protein S
KO64_08570	COG4550	Control of competence regulator ComK, YlbF/YmcA
KO64_08625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KO64_08630	COG3425	synthase
KO64_08635	COG1024	Enoyl-CoA hydratase
KO64_08640	COG1024	Enoyl-CoA hydratase
KO64_08645	COG3321	synthase
KO64_08645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KO64_08645	COG0318	PFAM AMP-dependent synthetase and ligase
KO64_08645	COG0300	oxidoreductase activity
KO64_08645	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_08650	COG0300	oxidoreductase activity
KO64_08650	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KO64_08650	COG4221	oxidoreductase activity
KO64_08650	COG3321	synthase
KO64_08655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KO64_08655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KO64_08655	COG3321	synthase
KO64_08655	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KO64_08655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KO64_08655	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_08655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KO64_08655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KO64_08655	COG3321	synthase
KO64_08655	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_08660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KO64_08660	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_08660	COG3321	synthase
KO64_08660	COG4221	oxidoreductase activity
KO64_08665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KO64_08665	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
KO64_08665	COG3321	synthase
KO64_08665	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
KO64_08670	COG2124	cytochrome p450
KO64_08675	COG3209	COG3209 Rhs family protein
KO64_08680	COG3619	membrane
KO64_08690	COG2801	Transposase and inactivated derivatives
KO64_08700	COG1404	Belongs to the peptidase S8 family
KO64_08710	COG4195	phage-related replication protein
KO64_08715	COG1764	response to oxidative stress
KO64_08725	COG2076	Multidrug Resistance protein
KO64_08765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KO64_08770	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
KO64_08775	COG4112	unkown
KO64_08780	COG0860	N-Acetylmuramoyl-L-alanine amidase
KO64_08790	COG0464	growth
KO64_08795	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
KO64_08800	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
KO64_08805	COG0789	Transcriptional regulator
KO64_08810	COG0174	glutamine synthetase
KO64_08825	COG2211	Major facilitator Superfamily
KO64_08830	COG3507	Belongs to the glycosyl hydrolase 43 family
KO64_08845	COG1070	Carbohydrate kinase
KO64_08850	COG0574	Belongs to the PEP-utilizing enzyme family
KO64_08850	COG3848	Pyruvate phosphate dikinase
KO64_08870	COG1064	alcohol dehydrogenase
KO64_08900	COG0456	acetyltransferase
KO64_08940	COG3397	chitin binding
KO64_08950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KO64_08960	COG5434	Belongs to the glycosyl hydrolase 28 family
KO64_08965	COG0756	dUTP diphosphatase activity
KO64_08975	COG4195	phage-related replication protein
KO64_09005	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KO64_09015	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
KO64_09035	COG0785	Cytochrome C biogenesis protein
KO64_09040	COG2201	protein-glutamate methylesterase activity
KO64_09045	COG4846	Membrane protein involved in cytochrome C biogenesis
KO64_09055	COG0071	Belongs to the small heat shock protein (HSP20) family
KO64_09070	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
KO64_09075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KO64_09095	COG0824	Thioesterase
KO64_09105	COG4841	protein insertion into membrane
KO64_09115	COG1832	CoA-binding protein
KO64_09120	COG0187	DNA topoisomerase II activity
KO64_09125	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
KO64_09140	COG1115	amino acid carrier protein
KO64_09150	COG2801	Transposase and inactivated derivatives
KO64_09160	COG1063	alcohol dehydrogenase
KO64_09165	COG0800	Aldolase
KO64_09170	COG1312	Catalyzes the dehydration of D-mannonate
KO64_09175	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_09180	COG1609	Transcriptional regulator
KO64_09185	COG2271	Major facilitator Superfamily
KO64_09230	COG2205	protein histidine kinase activity
KO64_09235	COG0745	RESPONSE REGULATOR receiver
KO64_09245	COG3507	Belongs to the glycosyl hydrolase 43 family
KO64_09270	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_09275	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KO64_09280	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KO64_09285	COG2610	gluconate transmembrane transporter activity
KO64_09290	COG2124	cytochrome p450
KO64_09295	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
KO64_09310	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KO64_09320	COG2246	polysaccharide biosynthetic process
KO64_09325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KO64_09330	COG0586	Pfam SNARE associated Golgi protein
KO64_09335	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KO64_09340	COG1024	Enoyl-CoA hydratase
KO64_09345	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
KO64_09350	COG0511	ligase activity, forming carbon-carbon bonds
KO64_09355	COG0439	Biotin carboxylase
KO64_09360	COG0318	PFAM AMP-dependent synthetase and ligase
KO64_09365	COG1960	acyl-CoA dehydrogenase activity
KO64_09370	COG1649	PFAM Uncharacterised BCR, COG1649
KO64_09380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KO64_09380	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
KO64_09385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KO64_09390	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KO64_09395	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KO64_09400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KO64_09405	COG2027	D-alanyl-D-alanine carboxypeptidase
KO64_09410	COG2017	converts alpha-aldose to the beta-anomer
KO64_09415	COG0534	Mate efflux family protein
KO64_09430	COG0582	viral genome integration into host DNA
KO64_09435	COG0166	Belongs to the GPI family
KO64_09440	COG0405	Gamma-glutamyltransferase
KO64_09445	COG2814	Major facilitator Superfamily
KO64_09450	COG0640	Transcriptional regulator
KO64_09455	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
KO64_09465	COG0604	alcohol dehydrogenase
KO64_09470	COG0493	'glutamate synthase
KO64_09475	COG0067	glutamate synthase
KO64_09475	COG0069	glutamate synthase activity
KO64_09475	COG0070	glutamate synthase
KO64_09480	COG0583	DNA-binding transcription factor activity
KO64_09485	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
KO64_09500	COG0300	oxidoreductase activity
KO64_09505	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
KO64_09515	COG2814	Major facilitator Superfamily
KO64_09520	COG1070	Carbohydrate kinase
KO64_09525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KO64_09530	COG0243	molybdopterin cofactor binding
KO64_09535	COG2801	Transposase and inactivated derivatives
KO64_09570	COG5444	nuclease activity
KO64_09575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KO64_09580	COG0662	Cupin 2, conserved barrel domain protein
KO64_09580	COG2207	Transcriptional regulator
KO64_09585	COG1309	transcriptional regulator
KO64_09590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KO64_09600	COG0640	Transcriptional regulator
KO64_09605	COG0741	lytic transglycosylase activity
KO64_09610	COG2322	membrane
KO64_09625	COG1619	proteins homologs of microcin C7 resistance protein MccF
KO64_09635	COG1388	LysM domain
KO64_09635	COG3584	3D domain protein
KO64_09640	COG0514	ATP-dependent DNA helicase (RecQ)
KO64_09645	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
KO64_09650	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KO64_09665	COG0071	Belongs to the small heat shock protein (HSP20) family
KO64_09690	COG1012	belongs to the aldehyde dehydrogenase family
KO64_09695	COG1657	PFAM Prenyltransferase squalene oxidase
KO64_09700	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KO64_09705	COG0733	neurotransmitter:sodium symporter activity
KO64_09710	COG0385	Bile acid
KO64_09715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KO64_09720	COG0508	dehydrogenase complex catalyzes the overall conversion of
KO64_09730	COG4548	von Willebrand factor, type A
KO64_09735	COG0714	Associated with various cellular activities
KO64_09740	COG2032	superoxide dismutase activity
KO64_09745	COG1388	LysM domain
KO64_09745	COG0791	NLP P60 protein
KO64_09750	COG1819	glycosyl
KO64_09755	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
KO64_09760	COG0534	Mate efflux family protein
KO64_09765	COG1366	Belongs to the anti-sigma-factor antagonist family
KO64_09770	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KO64_09775	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KO64_09785	COG2962	Rard protein
KO64_09800	COG1942	4-Oxalocrotonate Tautomerase
KO64_09810	COG1733	regulation of RNA biosynthetic process
KO64_09815	COG0778	Nitroreductase
KO64_09820	COG0400	carboxylic ester hydrolase activity
KO64_09825	COG0346	lactoylglutathione lyase activity
KO64_09835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
KO64_09845	COG2723	6-phospho-beta-galactosidase activity
KO64_09850	COG2188	Transcriptional regulator
KO64_09855	COG3409	Peptidoglycan-binding domain 1 protein
KO64_09855	COG0793	Belongs to the peptidase S41A family
KO64_09860	COG2226	methyltransferase
KO64_09870	COG1876	peptidase activity
KO64_09890	COG0671	phosphoesterase, PA-phosphatase related
KO64_09920	COG1509	lysine 2,3-aminomutase activity
KO64_09925	COG0456	acetyltransferase
KO64_09930	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KO64_09935	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
KO64_09940	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
KO64_09945	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
KO64_09960	COG0456	acetyltransferase
KO64_09965	COG0463	Glycosyl transferase, family 2
KO64_09980	COG4641	Protein conserved in bacteria
KO64_09990	COG1086	Polysaccharide biosynthesis protein
KO64_10000	COG3331	DNA recombination
KO64_10025	COG1388	LysM domain
KO64_10035	COG0457	Tetratricopeptide repeat
KO64_10055	COG5444	nuclease activity
KO64_10060	COG4282	regulation of fungal-type cell wall biogenesis
KO64_10065	COG1525	nuclease
KO64_10070	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
KO64_10090	COG1846	Transcriptional regulator
KO64_10095	COG4698	Protein conserved in bacteria
KO64_10100	COG2755	lipolytic protein G-D-S-L family
KO64_10105	COG1999	signal sequence binding
KO64_10115	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
KO64_10120	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
KO64_10125	COG1272	protein, Hemolysin III
KO64_10130	COG0204	Acyl-transferase
KO64_10135	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KO64_10150	COG2136	Putative SAM-dependent methyltransferase
KO64_10150	COG2521	methyltransferase
KO64_10165	COG1413	lyase activity
KO64_10170	COG1418	mRNA catabolic process
KO64_10175	COG0386	Belongs to the glutathione peroxidase family
KO64_10185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
KO64_10190	COG1278	Cold shock
KO64_10210	COG0328	RNA-DNA hybrid ribonuclease activity
KO64_10215	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
KO64_10220	COG0328	RNA-DNA hybrid ribonuclease activity
KO64_10230	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KO64_10245	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KO64_10250	COG1755	Isoprenylcysteine carboxyl methyltransferase
KO64_10255	COG3424	synthase
KO64_10275	COG2323	membrane
KO64_10280	COG1335	isochorismatase
KO64_10290	COG2233	PERMEase
KO64_10300	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
KO64_10305	COG1199	ATP-dependent helicase activity
KO64_10315	COG0116	Belongs to the methyltransferase superfamily
KO64_10335	COG3359	exonuclease
KO64_10340	COG1205	dead DEAH box helicase
KO64_10340	COG1111	helicase
KO64_10345	COG2190	(PTS) system
KO64_10350	COG0071	Belongs to the small heat shock protein (HSP20) family
KO64_10390	COG4499	WXG100 protein secretion system (Wss), protein YukC
KO64_10390	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KO64_10400	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
KO64_10405	COG3935	DnaD domain protein
KO64_10415	COG0436	Aminotransferase
KO64_10420	COG5353	protein conserved in bacteria
KO64_10430	COG1199	ATP-dependent helicase activity
KO64_10430	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
KO64_10460	COG0438	transferase activity, transferring glycosyl groups
KO64_10465	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KO64_10480	COG1694	Mazg nucleotide pyrophosphohydrolase
KO64_10485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KO64_10490	COG2140	Oxalate decarboxylase
KO64_10500	COG4347	Protein of unknown function (DUF1405)
KO64_10505	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KO64_10505	COG2010	Cytochrome c
KO64_10510	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
KO64_10515	COG0723	plastoquinol--plastocyanin reductase activity
KO64_10530	COG0457	Tetratricopeptide repeat
KO64_10540	COG0287	Prephenate dehydrogenase
KO64_10575	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KO64_10580	COG4401	Chorismate mutase type I
KO64_10595	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
KO64_10600	COG0105	UTP biosynthetic process
KO64_10605	COG0142	geranyltranstransferase activity
KO64_10615	COG0142	geranyltranstransferase activity
KO64_10630	COG0776	regulation of translation
KO64_10635	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
KO64_10675	COG0539	negative regulation of cytoplasmic translation
KO64_10690	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
KO64_10695	COG2959	enzyme of heme biosynthesis
KO64_10700	COG3773	Cell wall hydrolase
KO64_10700	COG3409	Peptidoglycan-binding domain 1 protein
KO64_10705	COG2339	peptidase activity
KO64_10710	COG0492	ferredoxin-NADP+ reductase activity
KO64_10715	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KO64_10720	COG4862	establishment of competence for transformation
KO64_10725	COG1408	metallophosphoesterase
KO64_10735	COG1388	LysM domain
KO64_10740	COG1266	CAAX protease self-immunity
KO64_10745	COG0514	ATP-dependent DNA helicase (RecQ)
KO64_10750	COG4955	Helix-turn-helix domain
KO64_10755	COG1141	Ferredoxin
KO64_10760	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
KO64_10765	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
KO64_10775	COG1595	DNA-templated transcription, initiation
KO64_10780	COG5002	protein histidine kinase activity
KO64_10785	COG0745	RESPONSE REGULATOR receiver
KO64_10790	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KO64_10795	COG1333	cytochrome c biogenesis protein
KO64_10800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KO64_10805	COG1187	pseudouridine synthase activity
KO64_10810	COG0700	Nucleoside recognition
KO64_10815	COG2715	membrane protein required for spore maturation
KO64_10820	COG1686	Belongs to the peptidase S11 family
KO64_10840	COG1547	Domain of unknown function (DUF309)
KO64_10845	COG0456	acetyltransferase
KO64_10860	COG0307	riboflavin synthase, alpha
KO64_10865	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KO64_10865	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
KO64_10875	COG0681	Belongs to the peptidase S26 family
KO64_10885	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
KO64_10890	COG4086	secreted protein
KO64_10895	COG0019	diaminopimelate decarboxylase activity
KO64_10900	COG0697	spore germination
KO64_10915	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
KO64_10935	COG1191	sigma factor activity
KO64_10945	COG1366	Belongs to the anti-sigma-factor antagonist family
KO64_10950	COG1686	Belongs to the peptidase S11 family
KO64_10955	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
KO64_10960	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
KO64_10965	COG4974	Belongs to the 'phage' integrase family
KO64_10975	COG0735	belongs to the Fur family
KO64_10980	COG1300	Membrane
KO64_10995	COG0281	malic enzyme
KO64_11000	COG1757	Na H antiporter
KO64_11005	COG1027	Aspartate ammonia-lyase
KO64_11010	COG0252	asparaginase activity
KO64_11015	COG1396	sequence-specific DNA binding
KO64_11020	COG1379	DNA repair
KO64_11025	COG0494	nUDIX hydrolase
KO64_11035	COG0667	Aldo Keto reductase
KO64_11045	COG1073	alpha beta
KO64_11055	COG4918	Iron-sulphur cluster biosynthesis
KO64_11060	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
KO64_11060	COG0456	acetyltransferase
KO64_11065	COG2329	Antibiotic biosynthesis monooxygenase
KO64_11070	COG0456	acetyltransferase
KO64_11075	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
KO64_11090	COG0628	permease
KO64_11095	COG0346	lactoylglutathione lyase activity
KO64_11105	COG3048	D-serine ammonia-lyase activity
KO64_11110	COG0300	oxidoreductase activity
KO64_11115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KO64_11120	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KO64_11125	COG1024	Enoyl-CoA hydratase
KO64_11130	COG3425	synthase
KO64_11135	COG2124	cytochrome p450
KO64_11140	COG3321	synthase
KO64_11140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KO64_11140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KO64_11140	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_11140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KO64_11145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KO64_11145	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KO64_11145	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_11145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KO64_11145	COG3321	synthase
KO64_11150	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_11150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KO64_11150	COG3321	synthase
KO64_11150	COG0300	oxidoreductase activity
KO64_11150	COG0318	PFAM AMP-dependent synthetase and ligase
KO64_11155	COG0318	PFAM AMP-dependent synthetase and ligase
KO64_11155	COG0300	oxidoreductase activity
KO64_11155	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_11155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KO64_11155	COG3321	synthase
KO64_11160	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_11160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KO64_11160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KO64_11160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KO64_11160	COG3321	synthase
KO64_11165	COG0300	oxidoreductase activity
KO64_11165	COG0318	PFAM AMP-dependent synthetase and ligase
KO64_11165	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KO64_11165	COG3321	synthase
KO64_11165	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_11170	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KO64_11170	COG3321	synthase
KO64_11170	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
KO64_11170	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_11170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KO64_11175	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_11180	COG0318	PFAM AMP-dependent synthetase and ligase
KO64_11195	COG2070	2-Nitropropane dioxygenase
KO64_11195	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
KO64_11200	COG0250	Participates in transcription elongation, termination and antitermination
KO64_11220	COG0596	Alpha beta hydrolase
KO64_11235	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
KO64_11240	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
KO64_11255	COG0706	membrane insertase activity
KO64_11260	COG2195	Cleaves the N-terminal amino acid of tripeptides
KO64_11265	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
KO64_11270	COG0346	lactoylglutathione lyase activity
KO64_11280	COG1376	ErfK ybiS ycfS ynhG family protein
KO64_11285	COG4129	membrane
KO64_11290	COG1126	abc transporter atp-binding protein
KO64_11295	COG0765	amino acid transport
KO64_11300	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KO64_11310	COG1597	lipid kinase activity
KO64_11315	COG0508	dehydrogenase complex catalyzes the overall conversion of
KO64_11320	COG0022	dehydrogenase e1 component
KO64_11325	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
KO64_11330	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
KO64_11335	COG3426	butyrate kinase activity
KO64_11340	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KO64_11345	COG0280	phosphate acetyltransferase
KO64_11350	COG3829	transcription factor binding
KO64_11350	COG3290	protein histidine kinase activity
KO64_11360	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
KO64_11365	COG2079	MmgE PrpD family protein
KO64_11370	COG0372	Belongs to the citrate synthase family
KO64_11375	COG1960	acyl-CoA dehydrogenase activity
KO64_11380	COG1250	3-hydroxyacyl-CoA dehydrogenase
KO64_11385	COG0183	Belongs to the thiolase family
KO64_11390	COG0584	glycerophosphoryl diester phosphodiesterase
KO64_11395	COG0860	N-Acetylmuramoyl-L-alanine amidase
KO64_11420	COG1902	pentaerythritol trinitrate reductase activity
KO64_11435	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
KO64_11440	COG0745	RESPONSE REGULATOR receiver
KO64_11445	COG0750	zinc metalloprotease
KO64_11450	COG0497	DNA recombination
KO64_11460	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
KO64_11470	COG0142	geranyltranstransferase activity
KO64_11480	COG1570	exodeoxyribonuclease VII activity
KO64_11495	COG1302	Protein conserved in bacteria
KO64_11500	COG0439	Biotin carboxylase
KO64_11505	COG0511	ligase activity, forming carbon-carbon bonds
KO64_11545	COG3854	ATPases associated with a variety of cellular activities
KO64_11560	COG0006	proline dipeptidase activity
KO64_11570	COG3872	metal-dependent enzyme
KO64_11580	COG1752	Esterase of the alpha-beta hydrolase superfamily
KO64_11595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KO64_11615	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KO64_11630	COG1396	sequence-specific DNA binding
KO64_11640	COG0681	Belongs to the peptidase S26 family
KO64_11665	COG4940	Competence protein ComGF
KO64_11675	COG4970	Tfp pilus assembly protein FimT
KO64_11680	COG4537	Required for transformation and DNA binding
KO64_11685	COG1459	type II secretion system
KO64_11690	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
KO64_11695	COG0598	Magnesium transport protein CorA
KO64_11700	COG1253	flavin adenine dinucleotide binding
KO64_11705	COG1366	Belongs to the anti-sigma-factor antagonist family
KO64_11715	COG1393	Belongs to the ArsC family
KO64_11725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KO64_11735	COG0011	TIGRFAM Protein of
KO64_11745	COG2866	Carboxypeptidase
KO64_11750	COG1940	carbohydrate kinase activity
KO64_11755	COG4483	Protein conserved in bacteria
KO64_11760	COG1757	Na H antiporter
KO64_11770	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
KO64_11775	COG0267	Belongs to the bacterial ribosomal protein bL33 family
KO64_11785	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KO64_11790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KO64_11795	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
KO64_11800	COG0581	inorganic phosphate transmembrane transporter activity
KO64_11805	COG0573	inorganic phosphate transmembrane transporter activity
KO64_11810	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
KO64_11820	COG0477	Major facilitator Superfamily
KO64_11825	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
KO64_11830	COG2839	Protein conserved in bacteria
KO64_11835	COG5521	maltodextrose utilization protein MalA
KO64_11840	COG1388	LysM domain
KO64_11850	COG4709	membrane
KO64_11855	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
KO64_11860	COG0735	belongs to the Fur family
KO64_11865	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KO64_11880	COG0513	Belongs to the DEAD box helicase family
KO64_11895	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
KO64_11900	COG2384	SAM-dependent methyltransferase
KO64_11905	COG2010	Cytochrome c
KO64_11910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
KO64_11915	COG0358	DNA primase activity
KO64_11930	COG0517	IMP dehydrogenase activity
KO64_11935	COG0751	glycine-tRNA ligase activity
KO64_11955	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
KO64_11960	COG0295	cytidine deaminase activity
KO64_11965	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
KO64_11975	COG1480	7TM receptor with intracellular HD hydrolase
KO64_11980	COG1702	phosphate starvation-inducible protein PhoH
KO64_11985	COG0561	phosphatase activity
KO64_12000	COG4864	UPF0365 protein
KO64_12005	COG1030	water channel activity
KO64_12010	COG1610	YqeY-like protein
KO64_12015	COG0828	Belongs to the bacterial ribosomal protein bS21 family
KO64_12020	COG1283	sodium-dependent phosphate transmembrane transporter activity
KO64_12025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
KO64_12030	COG1385	rRNA (uridine-N3-)-methyltransferase activity
KO64_12060	COG0635	Involved in the biosynthesis of porphyrin-containing compound
KO64_12075	COG0860	N-Acetylmuramoyl-L-alanine amidase
KO64_12090	COG1466	dna polymerase III delta subunit
KO64_12100	COG2333	competence protein COMEC
KO64_12100	COG0658	competence protein
KO64_12105	COG2131	deaminase
KO64_12110	COG1555	photosystem II stabilization
KO64_12110	COG1596	polysaccharide export
KO64_12115	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
KO64_12120	COG2226	methyltransferase
KO64_12125	COG0799	negative regulation of ribosome biogenesis
KO64_12130	COG1713	HD superfamily hydrolase involved in NAD metabolism
KO64_12140	COG1534	Rna-binding protein
KO64_12145	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
KO64_12150	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
KO64_12155	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
KO64_12165	COG2755	lipolytic protein G-D-S-L family
KO64_12170	COG0726	polysaccharide deacetylase
KO64_12175	COG0398	Pfam SNARE associated Golgi protein
KO64_12205	COG3708	Transcriptional regulator
KO64_12205	COG2207	Transcriptional regulator
KO64_12215	COG0563	adenylate kinase activity
KO64_12220	COG2814	Major facilitator Superfamily
KO64_12225	COG0456	acetyltransferase
KO64_12230	COG2318	DinB family
KO64_12240	COG0561	phosphatase activity
KO64_12245	COG0561	phosphatase activity
KO64_12255	COG1482	cell wall glycoprotein biosynthetic process
KO64_12260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KO64_12260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KO64_12260	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
KO64_12265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KO64_12265	COG3711	transcriptional antiterminator
KO64_12275	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
KO64_12280	COG0583	DNA-binding transcription factor activity
KO64_12285	COG2814	Major facilitator Superfamily
KO64_12290	COG2124	cytochrome p450
KO64_12290	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KO64_12295	COG1309	transcriptional regulator
KO64_12300	COG2226	methyltransferase
KO64_12310	COG2116	formate transmembrane transporter activity
KO64_12315	COG5609	conserved protein (DUF2294)
KO64_12320	COG3383	formate dehydrogenase (NAD+) activity
KO64_12325	COG2427	Protein of unknown function (DUF1641)
KO64_12335	COG0626	cystathionine gamma-synthase activity
KO64_12340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KO64_12365	COG0768	penicillin binding
KO64_12395	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
KO64_12410	COG4472	Bacterial protein of unknown function (DUF965)
KO64_12420	COG0628	permease
KO64_12425	COG1126	abc transporter atp-binding protein
KO64_12430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KO64_12435	COG0765	amino acid transport
KO64_12440	COG0765	amino acid transport
KO64_12455	COG3881	PFAM PRC-barrel domain
KO64_12460	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
KO64_12465	COG0457	Tetratricopeptide repeat
KO64_12475	COG1104	cysteine desulfurase activity
KO64_12480	COG1959	2 iron, 2 sulfur cluster binding
KO64_12485	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
KO64_12490	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
KO64_12515	COG0860	N-Acetylmuramoyl-L-alanine amidase
KO64_12515	COG4991	sh3 domain protein
KO64_12515	COG3103	Sh3 type 3 domain protein
KO64_12525	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
KO64_12535	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
KO64_12535	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
KO64_12540	COG5416	Lipopolysaccharide assembly protein A domain
KO64_12545	COG0490	domain, Protein
KO64_12550	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KO64_12550	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
KO64_12560	COG2244	polysaccharide biosynthetic process
KO64_12565	COG2323	membrane
KO64_12575	COG1862	Preprotein translocase
KO64_12620	COG1388	LysM domain
KO64_12630	COG0157	Belongs to the NadC ModD family
KO64_12635	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
KO64_12640	COG1104	cysteine desulfurase activity
KO64_12645	COG1827	regulation of RNA biosynthetic process
KO64_12650	COG0077	Prephenate dehydratase
KO64_12665	COG3290	protein histidine kinase activity
KO64_12670	COG0211	Belongs to the bacterial ribosomal protein bL27 family
KO64_12675	COG2868	ribosomal protein
KO64_12685	COG1994	Peptidase M50
KO64_12690	COG0739	heme binding
KO64_12695	COG2894	cell division
KO64_12705	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
KO64_12710	COG1792	Involved in formation and maintenance of cell shape
KO64_12715	COG1077	Cell shape determining protein MreB Mrl
KO64_12735	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
KO64_12740	COG0285	dihydrofolate synthase activity
KO64_12745	COG0525	valine-tRNA ligase activity
KO64_12755	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KO64_12760	COG1388	LysM domain
KO64_12770	COG0113	porphobilinogen synthase activity
KO64_12775	COG1587	Uroporphyrinogen-III synthase
KO64_12785	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
KO64_12805	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
KO64_12810	COG0470	DNA polymerase III
KO64_12810	COG1067	ATP-dependent peptidase activity
KO64_12825	COG1477	protein flavinylation
KO64_12825	COG0457	Tetratricopeptide repeat
KO64_12840	COG0473	3-isopropylmalate dehydrogenase activity
KO64_12855	COG0440	acetolactate synthase activity
KO64_12860	COG0028	Belongs to the TPP enzyme family
KO64_12885	COG0622	Phosphoesterase
KO64_12890	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
KO64_12900	COG5401	PFAM Sporulation and spore germination
KO64_12910	COG1846	Transcriptional regulator
KO64_12915	COG2197	response regulator
KO64_12920	COG0824	Thioesterase
KO64_12925	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
KO64_12930	COG1053	succinate dehydrogenase
KO64_12935	COG2009	succinate dehydrogenase
KO64_12945	COG1719	4-vinyl reductase, 4VR
KO64_12950	COG0527	aspartate kinase activity
KO64_12960	COG3118	belongs to the thioredoxin family
KO64_12965	COG3534	alpha-L-arabinofuranosidase
KO64_12970	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
KO64_12975	COG2086	electron transfer activity
KO64_12980	COG1024	Enoyl-CoA hydratase
KO64_12985	COG1309	transcriptional regulator
KO64_12990	COG0318	PFAM AMP-dependent synthetase and ligase
KO64_13000	COG3766	membrane
KO64_13010	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KO64_13010	COG1796	DNA polymerase
KO64_13015	COG1286	toxin biosynthetic process
KO64_13030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KO64_13030	COG0072	phenylalanine-tRNA ligase activity
KO64_13035	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
KO64_13040	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
KO64_13050	COG3835	regulator
KO64_13055	COG0277	FAD linked oxidase domain protein
KO64_13060	COG0247	lactate metabolic process
KO64_13065	COG1966	Carbon starvation protein
KO64_13070	COG3534	alpha-L-arabinofuranosidase
KO64_13075	COG0395	ABC-type sugar transport system, permease component
KO64_13080	COG1175	transmembrane transport
KO64_13085	COG1653	transport
KO64_13095	COG0647	UMP catabolic process
KO64_13100	COG0235	Class ii aldolase
KO64_13105	COG1069	ribulokinase activity
KO64_13110	COG2160	L-arabinose isomerase activity
KO64_13115	COG3507	Belongs to the glycosyl hydrolase 43 family
KO64_13120	COG1363	Peptidase, m42
KO64_13130	COG3326	Membrane
KO64_13135	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
KO64_13145	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
KO64_13150	COG1346	cytolysis
KO64_13155	COG1380	Effector of murein hydrolase LrgA
KO64_13160	COG3279	Response regulator of the LytR AlgR family
KO64_13165	COG3275	phosphorelay sensor kinase activity
KO64_13185	COG0398	Pfam SNARE associated Golgi protein
KO64_13190	COG1484	DNA-dependent DNA replication
KO64_13195	COG3611	Membrane attachment protein
KO64_13210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KO64_13215	COG1733	regulation of RNA biosynthetic process
KO64_13220	COG2814	Major facilitator Superfamily
KO64_13225	COG0656	L-ascorbic acid biosynthetic process
KO64_13230	COG0237	dephospho-CoA kinase activity
KO64_13235	COG1971	Probably functions as a manganese efflux pump
KO64_13240	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
KO64_13245	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KO64_13245	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
KO64_13250	COG5002	protein histidine kinase activity
KO64_13255	COG0745	RESPONSE REGULATOR receiver
KO64_13265	COG0538	isocitrate dehydrogenase activity
KO64_13270	COG0372	Belongs to the citrate synthase family
KO64_13285	COG0628	permease
KO64_13290	COG3030	protein affecting phage T7 exclusion by the F plasmid
KO64_13295	COG0469	pyruvate kinase activity
KO64_13320	COG0281	malic enzyme
KO64_13325	COG0587	DNA-directed DNA polymerase activity
KO64_13345	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
KO64_13355	COG4109	DRTGG domain
KO64_13365	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_13385	COG0521	Mo-molybdopterin cofactor biosynthetic process
KO64_13395	COG0827	DNA restriction-modification system
KO64_13400	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
KO64_13405	COG3874	Sporulation protein YtfJ
KO64_13415	COG1714	RDD family
KO64_13420	COG0616	signal peptide processing
KO64_13425	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
KO64_13430	COG1574	metal-dependent hydrolase with the TIM-barrel fold
KO64_13435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KO64_13450	COG1104	cysteine desulfurase activity
KO64_13455	COG1114	Component of the transport system for branched-chain amino acids
KO64_13465	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
KO64_13470	COG1309	transcriptional regulator
KO64_13475	COG1956	GAF domain-containing protein
KO64_13480	COG2203	Gaf domain
KO64_13480	COG2199	diguanylate cyclase activity
KO64_13490	COG1012	belongs to the aldehyde dehydrogenase family
KO64_13520	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KO64_13520	COG1017	nitric oxide dioxygenase activity
KO64_13530	COG0693	protein deglycase activity
KO64_13545	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
KO64_13550	COG1378	Sugar-specific transcriptional regulator TrmB
KO64_13570	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
KO64_13575	COG0454	-acetyltransferase
KO64_13580	COG0517	IMP dehydrogenase activity
KO64_13585	COG0123	including yeast histone deacetylase and acetoin utilization protein
KO64_13590	COG1360	Flagellar Motor Protein
KO64_13595	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
KO64_13600	COG1609	Transcriptional regulator
KO64_13605	COG1605	Chorismate mutase
KO64_13605	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
KO64_13610	COG3118	belongs to the thioredoxin family
KO64_13615	COG4980	gas vesicle protein
KO64_13620	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
KO64_13630	COG1674	ftsk spoiiie
KO64_13635	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
KO64_13645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KO64_13655	COG1363	Peptidase, m42
KO64_13660	COG5584	Small secreted protein
KO64_13665	COG0281	malic enzyme
KO64_13670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
KO64_13685	COG0510	thiamine kinase activity
KO64_13690	COG1597	lipid kinase activity
KO64_13700	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
KO64_13705	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
KO64_13710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KO64_13715	COG2252	PERMEase
KO64_13720	COG4473	ABC transporter
KO64_13725	COG1131	(ABC) transporter
KO64_13730	COG1349	DNA-binding transcription factor activity
KO64_13735	COG1187	pseudouridine synthase activity
KO64_13740	COG2244	polysaccharide biosynthetic process
KO64_13745	COG2081	HI0933 family
KO64_13750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
KO64_13780	COG1486	melibiose metabolic process
KO64_13790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
KO64_13805	COG1366	Belongs to the anti-sigma-factor antagonist family
KO64_13805	COG2202	Pas domain
KO64_13810	COG2814	Major facilitator Superfamily
KO64_13815	COG5522	Integral membrane protein (intg_mem_TP0381)
KO64_13820	COG0577	efflux transmembrane transporter activity
KO64_13825	COG1136	(ABC) transporter
KO64_13830	COG2205	protein histidine kinase activity
KO64_13835	COG0745	RESPONSE REGULATOR receiver
KO64_13840	COG0577	efflux transmembrane transporter activity
KO64_13845	COG1136	(ABC) transporter
KO64_13865	COG1131	(ABC) transporter
KO64_13870	COG1725	Transcriptional regulator
KO64_13885	COG0477	Major facilitator Superfamily
KO64_13890	COG1242	4 iron, 4 sulfur cluster binding
KO64_13895	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
KO64_13905	COG0584	glycerophosphoryl diester phosphodiesterase
KO64_13915	COG2267	carboxylic ester hydrolase activity
KO64_13920	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
KO64_13925	COG1113	amino acid transport
KO64_13930	COG0367	asparagine synthase
KO64_13950	COG1506	peptidase
KO64_13955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
KO64_13960	COG1116	anion transmembrane transporter activity
KO64_13965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
KO64_13970	COG0494	nUDIX hydrolase
KO64_13975	COG4824	toxin secretion phage lysis holin
KO64_13980	COG0783	Belongs to the Dps family
KO64_14005	COG0288	reversible hydration of carbon dioxide
KO64_14015	COG1271	oxidase subunit
KO64_14020	COG1294	oxidase, subunit
KO64_14035	COG4948	Mandelate Racemase Muconate Lactonizing
KO64_14045	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
KO64_14050	COG0596	Alpha beta hydrolase
KO64_14060	COG1169	isochorismate synthase
KO64_14065	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
KO64_14070	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
KO64_14075	COG2801	Transposase and inactivated derivatives
KO64_14205	COG3859	Proton-coupled thiamine transporter YuaJ
KO64_14210	COG2268	Band 7 protein
KO64_14215	COG1585	Membrane protein implicated in regulation of membrane protease activity
KO64_14220	COG2318	DinB family
KO64_14230	COG1454	alcohol dehydrogenase
KO64_14240	COG1510	regulation of RNA biosynthetic process
KO64_14250	COG0569	domain protein
KO64_14255	COG1705	Flagellar rod assembly protein muramidase FlgJ
KO64_14260	COG1017	nitric oxide dioxygenase activity
KO64_14260	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
KO64_14305	COG1196	nuclear chromosome segregation
KO64_14305	COG0741	lytic transglycosylase activity
KO64_14305	COG0739	heme binding
KO64_14310	COG0739	heme binding
KO64_14310	COG0741	lytic transglycosylase activity
KO64_14310	COG1196	nuclear chromosome segregation
KO64_14330	COG5444	nuclease activity
KO64_14340	COG1388	LysM domain
KO64_14340	COG5632	N-Acetylmuramoyl-L-alanine amidase
KO64_14340	COG3409	Peptidoglycan-binding domain 1 protein
KO64_14345	COG4824	toxin secretion phage lysis holin
KO64_14445	COG5484	DNA packaging
KO64_14450	COG3677	Transposase
KO64_14500	COG3935	DnaD domain protein
KO64_14555	COG3620	sequence-specific DNA binding
KO64_14565	COG2856	Zn peptidase
KO64_14570	COG0582	viral genome integration into host DNA
KO64_14585	COG0628	permease
KO64_14590	COG0673	inositol 2-dehydrogenase activity
KO64_14595	COG0693	protein deglycase activity
KO64_14600	COG0840	transmembrane signaling receptor activity
KO64_14605	COG0840	transmembrane signaling receptor activity
KO64_14610	COG0840	transmembrane signaling receptor activity
KO64_14615	COG0840	transmembrane signaling receptor activity
KO64_14630	COG2070	2-Nitropropane dioxygenase
KO64_14635	COG0432	Pfam Uncharacterised protein family UPF0047
KO64_14640	COG0366	Alpha amylase catalytic
KO64_14645	COG1253	flavin adenine dinucleotide binding
KO64_14650	COG2738	Putative neutral zinc metallopeptidase
KO64_14665	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
KO64_14695	COG1335	isochorismatase
KO64_14700	COG1979	alcohol dehydrogenase
KO64_14705	COG1979	alcohol dehydrogenase
KO64_14710	COG2155	Conserved Protein
KO64_14715	COG1098	S1 RNA binding domain
KO64_14720	COG0436	Aminotransferase
KO64_14725	COG1522	sequence-specific DNA binding
KO64_14730	COG2267	carboxylic ester hydrolase activity
KO64_14740	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
KO64_14745	COG2205	protein histidine kinase activity
KO64_14755	COG5018	Exonuclease
KO64_14765	COG2814	Major facilitator Superfamily
KO64_14770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KO64_14775	COG3011	Protein conserved in bacteria
KO64_14785	COG3290	protein histidine kinase activity
KO64_14790	COG4565	transcriptional regulatory protein
KO64_14820	COG2111	Na H antiporter
KO64_14820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
KO64_14825	COG2111	Na H antiporter
KO64_14830	COG1006	Multisubunit Na H antiporter MnhC subunit
KO64_14835	COG0651	ATP synthesis coupled electron transport
KO64_14840	COG1863	multisubunit Na H antiporter MnhE subunit
KO64_14845	COG2212	antiporter activity
KO64_14850	COG1320	monovalent cation:proton antiporter activity
KO64_14855	COG2050	protein possibly involved in aromatic compounds catabolism
KO64_14860	COG2197	response regulator
KO64_14875	COG0142	geranyltranstransferase activity
KO64_14895	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
KO64_14900	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
KO64_14905	COG1335	isochorismatase
KO64_14910	COG5506	Protein of unknown function (DUF1694)
KO64_14925	COG0628	permease
KO64_14935	COG1418	mRNA catabolic process
KO64_14940	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_14950	COG1511	domain protein
KO64_14955	COG0433	COG0433 Predicted ATPase
KO64_14955	COG1674	ftsk spoiiie
KO64_14960	COG4499	WXG100 protein secretion system (Wss), protein YukC
KO64_14965	COG5417	Belongs to the EsaB family
KO64_14970	COG4842	Belongs to the WXG100 family
KO64_14975	COG2508	Transcriptional regulator
KO64_14975	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
KO64_14980	COG0686	Belongs to the AlaDH PNT family
KO64_14985	COG5634	Uncharacterized conserved protein (DUF2278)
KO64_14990	COG3251	PFAM MbtH domain protein
KO64_14995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
KO64_15000	COG1535	isochorismatase
KO64_15000	COG3433	isochorismatase activity
KO64_15005	COG1021	2,3-dihydroxybenzoate-AMP ligase
KO64_15010	COG1169	isochorismate synthase
KO64_15015	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_15020	COG2819	hydrolase of the alpha beta superfamily
KO64_15025	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
KO64_15030	COG1268	BioY protein
KO64_15035	COG2056	Na+-H+ antiporter family
KO64_15045	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
KO64_15050	COG3584	3D domain protein
KO64_15060	COG1252	NADH dehydrogenase
KO64_15090	COG1131	(ABC) transporter
KO64_15110	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
KO64_15115	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
KO64_15120	COG0316	Belongs to the HesB IscA family
KO64_15130	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KO64_15140	COG1252	NADH dehydrogenase
KO64_15145	COG4837	Protein of unknown function (DUF1462)
KO64_15150	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
KO64_15155	COG1506	peptidase
KO64_15155	COG4946	Tricorn protease homolog
KO64_15155	COG0823	Involved in the tonB-independent uptake of proteins
KO64_15165	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
KO64_15170	COG0460	homoserine dehydrogenase
KO64_15175	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
KO64_15180	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
KO64_15185	COG0647	UMP catabolic process
KO64_15190	COG2445	Protein of unknown function DUF86
KO64_15195	COG4470	Protein conserved in bacteria
KO64_15205	COG0739	heme binding
KO64_15215	COG0737	Belongs to the 5'-nucleotidase family
KO64_15220	COG0730	response to heat
KO64_15225	COG1801	Protein of unknown function DUF72
KO64_15240	COG2508	Transcriptional regulator
KO64_15250	COG2801	Transposase and inactivated derivatives
KO64_15270	COG2814	Major facilitator Superfamily
KO64_15275	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
KO64_15280	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
KO64_15285	COG2356	endonuclease I
KO64_15290	COG3842	ATPase activity
KO64_15295	COG2188	Transcriptional regulator
KO64_15300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KO64_15305	COG0395	ABC-type sugar transport system, permease component
KO64_15310	COG1175	transmembrane transport
KO64_15315	COG1653	transport
KO64_15320	COG2222	sugar isomerase
KO64_15325	COG0789	Transcriptional regulator
KO64_15350	COG0322	excinuclease ABC activity
KO64_15355	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
KO64_15360	COG2226	methyltransferase
KO64_15370	COG3409	Peptidoglycan-binding domain 1 protein
KO64_15375	COG0719	Fe-S assembly protein
KO64_15380	COG0822	iron-sulfur transferase activity
KO64_15385	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
KO64_15390	COG0719	Fe-S assembly protein
KO64_15395	COG0396	ATPase activity
KO64_15405	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KO64_15410	COG1464	Belongs to the NlpA lipoprotein family
KO64_15415	COG2011	ABC-type metal ion transport system permease component
KO64_15420	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
KO64_15430	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
KO64_15435	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
KO64_15450	COG1393	Belongs to the ArsC family
KO64_15455	COG1960	acyl-CoA dehydrogenase activity
KO64_15460	COG0183	Belongs to the thiolase family
KO64_15465	COG1250	3-hydroxyacyl-CoA dehydrogenase
KO64_15465	COG1024	Enoyl-CoA hydratase
KO64_15485	COG5577	PFAM Coat F domain
KO64_15490	COG1846	Transcriptional regulator
KO64_15495	COG0477	Major facilitator Superfamily
KO64_15500	COG0583	DNA-binding transcription factor activity
KO64_15520	COG1120	ATPase activity
KO64_15535	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_15540	COG0783	Belongs to the Dps family
KO64_15545	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KO64_15550	COG0745	RESPONSE REGULATOR receiver
KO64_15555	COG2770	Histidine kinase
KO64_15555	COG2205	protein histidine kinase activity
KO64_15565	COG1309	transcriptional regulator
KO64_15570	COG0114	fumarate hydratase activity
KO64_15580	COG0697	spore germination
KO64_15585	COG0814	amino acid
KO64_15595	COG2197	response regulator
KO64_15600	COG4585	Histidine kinase
KO64_15605	COG4758	membrane
KO64_15610	COG3595	metallopeptidase activity
KO64_15615	COG1842	Phage shock protein A
KO64_15620	COG4758	membrane
KO64_15625	COG2814	Major facilitator Superfamily
KO64_15630	COG2096	Adenosyltransferase
KO64_15635	COG1120	ATPase activity
KO64_15640	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KO64_15645	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KO64_15650	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_15655	COG3386	PFAM SMP-30 Gluconolaconase
KO64_15660	COG2205	protein histidine kinase activity
KO64_15665	COG0745	RESPONSE REGULATOR receiver
KO64_15675	COG1191	sigma factor activity
KO64_15685	COG2140	Oxalate decarboxylase
KO64_15695	COG1120	ATPase activity
KO64_15700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KO64_15705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KO64_15710	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KO64_15715	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
KO64_15720	COG0531	amino acid
KO64_15735	COG1988	membrane-bound metal-dependent
KO64_15740	COG1368	sulfuric ester hydrolase activity
KO64_15745	COG1910	domain protein
KO64_15750	COG0725	ABC transporter, periplasmic molybdate-binding protein
KO64_15755	COG4149	molybdate abc transporter
KO64_15760	COG2197	response regulator
KO64_15765	COG3850	Histidine kinase
KO64_15770	COG1131	(ABC) transporter
KO64_15780	COG0842	Transport permease protein
KO64_15785	COG0656	L-ascorbic acid biosynthetic process
KO64_15810	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
KO64_15815	COG3973	AAA domain
KO64_15820	COG2860	membrane
KO64_15830	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
KO64_15835	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
KO64_15840	COG2217	Heavy metal translocating P-type atpase
KO64_15845	COG2217	Heavy metal translocating P-type atpase
KO64_15850	COG2608	mercury ion transmembrane transporter activity
KO64_15855	COG1937	Protein conserved in bacteria
KO64_15860	COG0673	inositol 2-dehydrogenase activity
KO64_15875	COG2814	Major facilitator Superfamily
KO64_15890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KO64_15895	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
KO64_15900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KO64_15905	COG1126	abc transporter atp-binding protein
KO64_15910	COG0765	amino acid transport
KO64_15915	COG0765	amino acid transport
KO64_15920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KO64_15925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
KO64_15930	COG0454	-acetyltransferase
KO64_15935	COG0583	DNA-binding transcription factor activity
KO64_15940	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_15945	COG2732	(Barnase) inhibitor
KO64_15965	COG0557	exoribonuclease II activity
KO64_15970	COG1647	Serine aminopeptidase, S33
KO64_15975	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
KO64_15980	COG1476	TRANSCRIPTIONal
KO64_15985	COG1396	sequence-specific DNA binding
KO64_15990	COG1396	sequence-specific DNA binding
KO64_15995	COG1733	regulation of RNA biosynthetic process
KO64_16025	COG1174	glycine betaine transport
KO64_16030	COG1732	Glycine betaine
KO64_16035	COG1174	glycine betaine transport
KO64_16040	COG1125	glycine betaine transport
KO64_16040	COG0517	IMP dehydrogenase activity
KO64_16045	COG1510	regulation of RNA biosynthetic process
KO64_16050	COG1174	glycine betaine transport
KO64_16055	COG1732	Glycine betaine
KO64_16060	COG1174	glycine betaine transport
KO64_16065	COG1125	glycine betaine transport
KO64_16065	COG0517	IMP dehydrogenase activity
KO64_16090	COG1174	glycine betaine transport
KO64_16095	COG0517	IMP dehydrogenase activity
KO64_16095	COG1125	glycine betaine transport
KO64_16100	COG1510	regulation of RNA biosynthetic process
KO64_16105	COG1174	glycine betaine transport
KO64_16110	COG1732	Glycine betaine
KO64_16115	COG1174	glycine betaine transport
KO64_16120	COG0517	IMP dehydrogenase activity
KO64_16120	COG1125	glycine betaine transport
KO64_16125	COG1510	regulation of RNA biosynthetic process
KO64_16130	COG2095	MarC family integral membrane protein
KO64_16135	COG3064	Membrane
KO64_16140	COG4640	response to antibiotic
KO64_16145	COG0456	acetyltransferase
KO64_16160	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
KO64_16180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
KO64_16185	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KO64_16195	COG2234	aminopeptidase activity
KO64_16215	COG0126	phosphoglycerate kinase activity
KO64_16225	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
KO64_16230	COG2390	Transcriptional regulator
KO64_16235	COG2814	Major facilitator Superfamily
KO64_16240	COG1609	Transcriptional regulator
KO64_16245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KO64_16255	COG0583	DNA-binding transcription factor activity
KO64_16260	COG0697	spore germination
KO64_16265	COG2801	Transposase and inactivated derivatives
KO64_16275	COG1113	amino acid transport
KO64_16285	COG1609	Transcriptional regulator
KO64_16295	COG0561	phosphatase activity
KO64_16300	COG1737	Transcriptional regulator
KO64_16305	COG1070	Carbohydrate kinase
KO64_16335	COG2186	Transcriptional regulator
KO64_16340	COG1620	l-lactate permease
KO64_16345	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
KO64_16355	COG5039	Polysaccharide pyruvyl transferase
KO64_16360	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KO64_16365	COG0110	maltose O-acetyltransferase activity
KO64_16370	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
KO64_16375	COG2244	polysaccharide biosynthetic process
KO64_16380	COG1216	Glycosyl transferase, family 2
KO64_16385	COG5039	Polysaccharide pyruvyl transferase
KO64_16390	COG1216	Glycosyl transferase, family 2
KO64_16400	COG0438	transferase activity, transferring glycosyl groups
KO64_16405	COG1215	transferase activity, transferring glycosyl groups
KO64_16410	COG0438	transferase activity, transferring glycosyl groups
KO64_16415	COG1086	Polysaccharide biosynthesis protein
KO64_16420	COG0489	protein tyrosine kinase activity
KO64_16425	COG3944	biosynthesis protein
KO64_16430	COG1396	sequence-specific DNA binding
KO64_16435	COG2272	Belongs to the type-B carboxylesterase lipase family
KO64_16440	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
KO64_16445	COG2364	Membrane
KO64_16450	COG0456	acetyltransferase
KO64_16455	COG3479	Phenolic acid decarboxylase
KO64_16500	COG2223	nitrite transmembrane transporter activity
KO64_16505	COG1609	Transcriptional regulator
KO64_16515	COG0583	DNA-binding transcription factor activity
KO64_16520	COG2828	Protein conserved in bacteria
KO64_16525	COG0477	Major facilitator Superfamily
KO64_16525	COG2814	Major facilitator Superfamily
KO64_16530	COG1611	Belongs to the LOG family
KO64_16535	COG1694	Mazg nucleotide pyrophosphohydrolase
KO64_16540	COG0659	secondary active sulfate transmembrane transporter activity
KO64_16545	COG0288	reversible hydration of carbon dioxide
KO64_16555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
KO64_16560	COG4290	ribonuclease
KO64_16565	COG2162	N-hydroxyarylamine O-acetyltransferase activity
KO64_16570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
KO64_16580	COG0391	Required for morphogenesis under gluconeogenic growth conditions
KO64_16590	COG1051	belongs to the nudix hydrolase family
KO64_16595	COG0492	ferredoxin-NADP+ reductase activity
KO64_16600	COG3883	PFAM NLP P60 protein
KO64_16600	COG0791	NLP P60 protein
KO64_16605	COG0457	Tetratricopeptide repeat
KO64_16610	COG5002	protein histidine kinase activity
KO64_16615	COG0745	RESPONSE REGULATOR receiver
KO64_16620	COG1132	(ABC) transporter
KO64_16625	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
KO64_16625	COG0140	phosphoribosyl-ATP diphosphatase activity
KO64_16650	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
KO64_16665	COG4990	cell redox homeostasis
KO64_16670	COG0110	maltose O-acetyltransferase activity
KO64_16690	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
KO64_16705	COG1309	transcriptional regulator
KO64_16710	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
KO64_16715	COG1950	PFAM Membrane protein of
KO64_16720	COG1983	PspC domain protein
KO64_16725	COG3595	metallopeptidase activity
KO64_16740	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
KO64_16750	COG4897	Protein conserved in bacteria
KO64_16755	COG3848	Pyruvate phosphate dikinase
KO64_16755	COG0574	Belongs to the PEP-utilizing enzyme family
KO64_16760	COG1309	transcriptional regulator
KO64_16765	COG2814	Major facilitator Superfamily
KO64_16780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KO64_16790	COG3409	Peptidoglycan-binding domain 1 protein
KO64_16790	COG0793	Belongs to the peptidase S41A family
KO64_16795	COG3420	alginic acid biosynthetic process
KO64_16800	COG2177	Part of the ABC transporter FtsEX involved in
KO64_16805	COG2884	Cell division ATP-binding protein ftsE
KO64_16810	COG2010	Cytochrome c
KO64_16815	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KO64_16820	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
KO64_16830	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
KO64_16845	COG1516	flagellar protein fliS
KO64_16850	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
KO64_16855	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KO64_16875	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
KO64_16880	COG4786	Flagellar basal body rod
KO64_16880	COG1256	bacterial-type flagellum assembly
KO64_16885	COG3418	PFAM FlgN family protein
KO64_16890	COG2747	anti-sigma28 factor FlgM
KO64_16900	COG1040	competence protein
KO64_16910	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
KO64_16915	COG1307	EDD domain protein, DegV family
KO64_16920	COG2197	response regulator
KO64_16925	COG4585	Histidine kinase
KO64_16930	COG1739	Uncharacterized protein family UPF0029
KO64_16935	COG1316	TRANSCRIPTIONal
KO64_16940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
KO64_16945	COG0438	transferase activity, transferring glycosyl groups
KO64_16950	COG1215	transferase activity, transferring glycosyl groups
KO64_16955	COG3206	protein involved in exopolysaccharide biosynthesis
KO64_16960	COG3307	-O-antigen
KO64_16965	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KO64_16970	COG0297	glycogen (starch) synthase activity
KO64_16970	COG0438	transferase activity, transferring glycosyl groups
KO64_16975	COG2244	polysaccharide biosynthetic process
KO64_16985	COG0860	N-Acetylmuramoyl-L-alanine amidase
KO64_16985	COG2247	cell wall binding repeat
KO64_16990	COG2385	sporulation resulting in formation of a cellular spore
KO64_16990	COG2247	cell wall binding repeat
KO64_17000	COG1316	TRANSCRIPTIONal
KO64_17005	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
KO64_17010	COG1210	Utp--glucose-1-phosphate uridylyltransferase
KO64_17015	COG1134	teichoic acid transport
KO64_17020	COG1682	transport, permease protein
KO64_17025	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KO64_17035	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
KO64_17040	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
KO64_17045	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KO64_17050	COG4193	domain, Protein
KO64_17055	COG1482	cell wall glycoprotein biosynthetic process
KO64_17060	COG0697	spore germination
KO64_17065	COG0814	amino acid
KO64_17075	COG1215	transferase activity, transferring glycosyl groups
KO64_17080	COG2814	Major facilitator Superfamily
KO64_17085	COG1316	TRANSCRIPTIONal
KO64_17090	COG0561	phosphatase activity
KO64_17095	COG2433	Pfam Transposase IS66
KO64_17100	COG0791	NLP P60 protein
KO64_17120	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
KO64_17125	COG0697	spore germination
KO64_17130	COG0814	amino acid
KO64_17140	COG1609	Transcriptional regulator
KO64_17145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
KO64_17155	COG1129	ABC transporter
KO64_17160	COG1172	Belongs to the binding-protein-dependent transport system permease family
KO64_17165	COG1879	ABC-type sugar transport system periplasmic component
KO64_17170	COG3103	Sh3 type 3 domain protein
KO64_17175	COG2249	NAD(P)H dehydrogenase (quinone) activity
KO64_17180	COG3527	Alpha-acetolactate decarboxylase
KO64_17185	COG0028	Belongs to the TPP enzyme family
KO64_17190	COG0583	DNA-binding transcription factor activity
KO64_17195	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KO64_17210	COG5337	Spore coat protein CotH
KO64_17220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
KO64_17230	COG0405	Gamma-glutamyltransferase
KO64_17235	COG1522	sequence-specific DNA binding
KO64_17240	COG2059	Chromate
KO64_17245	COG2059	Chromate
KO64_17260	COG5444	nuclease activity
KO64_17275	COG3878	Protein conserved in bacteria
KO64_17280	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
KO64_17285	COG4464	protein tyrosine phosphatase activity
KO64_17290	COG0489	protein tyrosine kinase activity
KO64_17295	COG3944	biosynthesis protein
KO64_17305	COG4715	Zinc finger, swim domain protein
KO64_17310	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
KO64_17315	COG0561	phosphatase activity
KO64_17320	COG1349	DNA-binding transcription factor activity
KO64_17325	COG0629	single-stranded DNA binding
KO64_17350	COG0457	Tetratricopeptide repeat
KO64_17355	COG4786	Flagellar basal body rod
KO64_17360	COG4786	Flagellar basal body rod
KO64_17365	COG1077	Cell shape determining protein MreB Mrl
KO64_17370	COG1609	Transcriptional regulator
KO64_17375	COG1846	Transcriptional regulator
KO64_17380	COG2814	Major facilitator Superfamily
KO64_17385	COG1953	Uracil, thiamine, allantoin
KO64_17390	COG0477	Major facilitator Superfamily
KO64_17395	COG1335	isochorismatase
KO64_17400	COG0004	ammonium transporteR
KO64_17405	COG0347	Belongs to the P(II) protein family
KO64_17410	COG0772	Belongs to the SEDS family
KO64_17415	COG0671	phosphoesterase, PA-phosphatase related
KO64_17425	COG0739	heme binding
KO64_17430	COG1247	-acetyltransferase
KO64_17445	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KO64_17460	COG0726	polysaccharide deacetylase
KO64_17470	COG1959	2 iron, 2 sulfur cluster binding
KO64_17485	COG0831	urea catabolic process
KO64_17490	COG3237	CsbD-like
KO64_17495	COG1994	Peptidase M50
KO64_17500	COG0457	Tetratricopeptide repeat
KO64_17510	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
KO64_17520	COG2304	oxidoreductase activity
KO64_17525	COG2304	oxidoreductase activity
KO64_17530	COG2385	sporulation resulting in formation of a cellular spore
KO64_17535	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KO64_17545	COG4836	Membrane
KO64_17585	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
KO64_17615	COG0698	ribose 5-phosphate isomerase
KO64_17620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
KO64_17630	COG0009	L-threonylcarbamoyladenylate synthase
KO64_17635	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
KO64_17655	COG2890	protein-(glutamine-N5) methyltransferase activity
KO64_17660	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
KO64_17665	COG0346	lactoylglutathione lyase activity
KO64_17670	COG0789	Transcriptional regulator
KO64_17675	COG0679	Auxin Efflux Carrier
KO64_17680	COG0281	malic enzyme
KO64_17690	COG0254	rRNA binding
KO64_17695	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
KO64_17700	COG1494	fructose-1,6-bisphosphatase
KO64_17705	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
KO64_17720	COG0191	fructose-bisphosphate aldolase activity
KO64_17725	COG2204	response regulator
KO64_17730	COG4821	SIS domain
KO64_17745	COG0247	lactate metabolic process
KO64_17745	COG2181	nitrate reductase activity
KO64_17750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KO64_17765	COG1132	(ABC) transporter
KO64_17770	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
KO64_17780	COG2181	nitrate reductase activity
KO64_17785	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
KO64_17790	COG1140	nitrate reductase beta subunit
KO64_17795	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
KO64_17800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KO64_17810	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
KO64_17815	COG2223	nitrite transmembrane transporter activity
KO64_17825	COG4506	Protein conserved in bacteria
KO64_17835	COG3391	amine dehydrogenase activity
KO64_17840	COG3391	amine dehydrogenase activity
KO64_17850	COG0457	Tetratricopeptide repeat
KO64_17895	COG0010	Belongs to the arginase family
KO64_17900	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
KO64_17905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
KO64_17920	COG1994	Peptidase M50
KO64_17925	COG1942	4-Oxalocrotonate Tautomerase
KO64_17930	COG1846	Transcriptional regulator
KO64_17935	COG0531	amino acid
KO64_17940	COG3465	dGTPase activity
KO64_17945	COG1078	dGTPase activity
KO64_17960	COG1695	Transcriptional regulator
KO64_17970	COG1131	(ABC) transporter
KO64_17975	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
KO64_18005	COG0583	DNA-binding transcription factor activity
KO64_18010	COG2855	membrane
KO64_18015	COG0280	phosphate acetyltransferase
KO64_18025	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_18030	COG0436	Aminotransferase
KO64_18060	COG2814	Major facilitator Superfamily
KO64_18065	COG2814	Major facilitator Superfamily
KO64_18070	COG0833	amino acid
KO64_18075	COG4187	Peptidase family M20/M25/M40
KO64_18080	COG1012	belongs to the aldehyde dehydrogenase family
KO64_18085	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
KO64_18095	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
KO64_18100	COG1091	dTDP-4-dehydrorhamnose reductase activity
KO64_18105	COG1088	dTDP-glucose 4,6-dehydratase activity
KO64_18110	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
KO64_18115	COG3980	spore coat polysaccharide biosynthesis protein
KO64_18120	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
KO64_18125	COG2089	acid synthase
KO64_18130	COG0456	acetyltransferase
KO64_18135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
KO64_18140	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
KO64_18145	COG0463	Glycosyl transferase, family 2
KO64_18155	COG2363	Small membrane protein
KO64_18160	COG2233	PERMEase
KO64_18175	COG1216	Glycosyl transferase, family 2
KO64_18190	COG1695	Transcriptional regulator
KO64_18195	COG0351	phosphomethylpyrimidine kinase
KO64_18205	COG1621	beta-fructofuranosidase activity
KO64_18210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KO64_18210	COG1263	PTS System
KO64_18215	COG3711	transcriptional antiterminator
KO64_18225	COG1404	Belongs to the peptidase S8 family
KO64_18230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
KO64_18235	COG0778	Nitroreductase
KO64_18240	COG0772	Belongs to the SEDS family
KO64_18245	COG0454	-acetyltransferase
KO64_18265	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
KO64_18270	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
KO64_18275	COG2261	transglycosylase associated protein
KO64_18280	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
KO64_18285	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
KO64_18290	COG2246	polysaccharide biosynthetic process
KO64_18295	COG1309	transcriptional regulator
KO64_18315	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
KO64_18320	COG2837	iron assimilation
KO64_18325	COG2822	iron ion transport
KO64_18340	COG0583	DNA-binding transcription factor activity
KO64_18350	COG1346	cytolysis
KO64_18355	COG4895	conserved protein (DUF2196)
KO64_18360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
KO64_18365	COG0346	lactoylglutathione lyase activity
KO64_18370	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KO64_18375	COG1404	Belongs to the peptidase S8 family
KO64_18380	COG1442	glycosyl transferase family 8
KO64_18390	COG2357	RelA SpoT domain protein
KO64_18395	COG1575	Belongs to the MenA family. Type 1 subfamily
KO64_18410	COG1696	Membrane protein involved in D-alanine export
KO64_18420	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
KO64_18425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
KO64_18430	COG1486	melibiose metabolic process
KO64_18435	COG1447	Phosphotransferase system cellobiose-specific component IIA
KO64_18440	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KO64_18445	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KO64_18450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
KO64_18450	COG3711	transcriptional antiterminator
KO64_18460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KO64_18465	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
KO64_18475	COG0640	Transcriptional regulator
KO64_18480	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
KO64_18490	COG1447	Phosphotransferase system cellobiose-specific component IIA
KO64_18495	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
KO64_18500	COG2723	6-phospho-beta-galactosidase activity
KO64_18505	COG1940	carbohydrate kinase activity
KO64_18510	COG1482	cell wall glycoprotein biosynthetic process
KO64_18520	COG0753	catalase activity
KO64_18525	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
KO64_18530	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
KO64_18535	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
KO64_18540	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
KO64_18545	COG4988	ABC transporter
KO64_18550	COG1294	oxidase, subunit
KO64_18555	COG1271	oxidase subunit
KO64_18560	COG3493	citrate carrier protein
KO64_18565	COG0726	polysaccharide deacetylase
KO64_18570	COG3842	ATPase activity
KO64_18575	COG2508	Transcriptional regulator
KO64_18580	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KO64_18590	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
KO64_18605	COG4894	glucomannan catabolic process
KO64_18610	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
KO64_18615	COG0500	methyltransferase
KO64_18620	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KO64_18635	COG0693	protein deglycase activity
KO64_18635	COG0753	catalase activity
KO64_18640	COG2851	Citrate transporter
KO64_18645	COG2273	Hydrolase Family 16
KO64_18650	COG3711	transcriptional antiterminator
KO64_18655	COG2270	Major facilitator Superfamily
KO64_18660	COG0513	Belongs to the DEAD box helicase family
KO64_18730	COG0697	spore germination
KO64_18735	COG0589	response to stress
KO64_18740	COG2723	6-phospho-beta-galactosidase activity
KO64_18745	COG1263	PTS System
KO64_18745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
KO64_18745	COG2190	(PTS) system
KO64_18760	COG0494	nUDIX hydrolase
KO64_18765	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
KO64_18770	COG3507	Belongs to the glycosyl hydrolase 43 family
KO64_18795	COG0010	Belongs to the arginase family
KO64_18800	COG0833	amino acid
KO64_18805	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
KO64_18810	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
KO64_18820	COG2390	Transcriptional regulator
KO64_18825	COG0561	phosphatase activity
KO64_18855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
KO64_18860	COG5294	Protein conserved in bacteria
KO64_18865	COG0577	efflux transmembrane transporter activity
KO64_18870	COG1136	(ABC) transporter
KO64_18875	COG2205	protein histidine kinase activity
KO64_18880	COG0745	RESPONSE REGULATOR receiver
KO64_18895	COG1082	Xylose isomerase domain protein TIM barrel
KO64_18905	COG2814	Major facilitator Superfamily
KO64_18935	COG1349	DNA-binding transcription factor activity
KO64_18940	COG0667	Aldo Keto reductase
KO64_18945	COG2814	Major facilitator Superfamily
KO64_18960	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_18965	COG2197	response regulator
KO64_18970	COG4585	Histidine kinase
KO64_18975	COG3239	Fatty acid desaturase
KO64_18980	COG1309	transcriptional regulator
KO64_18985	COG1012	belongs to the aldehyde dehydrogenase family
KO64_18990	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
KO64_19000	COG0640	Transcriptional regulator
KO64_19005	COG2814	Major facilitator Superfamily
KO64_19010	COG1714	RDD family
KO64_19020	COG0450	alkyl hydroperoxide reductase
KO64_19025	COG3634	alkyl hydroperoxide reductase activity
KO64_19030	COG3177	Filamentation induced by cAMP protein fic
KO64_19035	COG1113	amino acid transport
KO64_19045	COG2080	2 iron, 2 sulfur cluster binding
KO64_19060	COG2068	MobA-Related Protein
KO64_19065	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
KO64_19075	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
KO64_19095	COG0232	Belongs to the dGTPase family. Type 2 subfamily
KO64_19115	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
KO64_19120	COG0667	Aldo Keto reductase
KO64_19125	COG0456	acetyltransferase
KO64_19130	COG0457	Tetratricopeptide repeat
KO64_19135	COG0010	Belongs to the arginase family
KO64_19140	COG0833	amino acid
KO64_19145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
KO64_19150	COG3829	transcription factor binding
KO64_19160	COG0488	(ABC) transporter
KO64_19175	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
KO64_19180	COG5002	protein histidine kinase activity
KO64_19180	COG3850	Histidine kinase
KO64_19185	COG0745	RESPONSE REGULATOR receiver
KO64_19190	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
KO64_19195	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
KO64_19200	COG4853	Protein conserved in bacteria
KO64_19205	COG4863	YycH protein
KO64_19210	COG5002	protein histidine kinase activity
KO64_19215	COG0745	RESPONSE REGULATOR receiver
KO64_19250	COG0346	lactoylglutathione lyase activity
KO64_19255	COG0305	Participates in initiation and elongation during chromosome replication
KO64_19275	COG3093	addiction module antidote protein HigA
KO64_19280	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
KO64_19295	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
KO64_19300	COG0438	transferase activity, transferring glycosyl groups
KO64_19320	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
KO64_19325	COG4241	membrane
KO64_19335	COG5577	PFAM Coat F domain
KO64_19340	COG1733	regulation of RNA biosynthetic process
KO64_19355	COG2801	Transposase and inactivated derivatives
KO64_19360	COG0697	spore germination
KO64_19365	COG1621	beta-fructofuranosidase activity
KO64_19370	COG1621	beta-fructofuranosidase activity
KO64_19375	COG1802	Transcriptional regulator
KO64_19380	COG2318	DinB family
KO64_19385	COG2211	Major facilitator Superfamily
KO64_19390	COG2197	response regulator
KO64_19395	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
KO64_19395	COG0512	Glutamine amidotransferase of anthranilate synthase
KO64_19400	COG0697	spore germination
KO64_19410	COG0583	DNA-binding transcription factor activity
KO64_19425	COG0778	Nitroreductase
KO64_19430	COG1846	Transcriptional regulator
KO64_19435	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
KO64_19440	COG1846	Transcriptional regulator
KO64_19445	COG2153	protein acetylation
KO64_19455	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
KO64_19460	COG0583	DNA-binding transcription factor activity
KO64_19465	COG1028	Short-chain dehydrogenase reductase Sdr
KO64_19470	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
KO64_19475	COG0697	spore germination
KO64_19480	COG1331	Highly conserved protein containing a thioredoxin domain
KO64_19485	COG1266	CAAX protease self-immunity
KO64_19490	COG2814	Major facilitator Superfamily
KO64_19490	COG0477	Major facilitator Superfamily
KO64_19495	COG0346	lactoylglutathione lyase activity
KO64_19500	COG1609	Transcriptional regulator
KO64_19505	COG0708	Exodeoxyribonuclease III
KO64_19510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
KO64_19515	COG2169	Transcriptional regulator
KO64_19525	COG0629	single-stranded DNA binding
KO64_19535	COG0012	GTP binding
KO64_19540	COG0243	molybdopterin cofactor binding
KO64_19545	COG4481	Protein conserved in bacteria
KO64_19550	COG3949	Membrane
KO64_19565	COG1475	DNA binding
KO64_19570	COG1192	Involved in chromosome partitioning
KO64_19595	COG1847	R3H domain protein
KO64_19600	COG0706	membrane insertase activity