locus-tag	class	description
IHV08_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
IHV08_00010	COG0592	DNA-directed DNA polymerase activity
IHV08_00015	COG2501	S4 domain
IHV08_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
IHV08_00030	COG0187	DNA topoisomerase II activity
IHV08_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IHV08_00070	COG0516	GMP reductase activity
IHV08_00070	COG0517	IMP dehydrogenase activity
IHV08_00075	COG1686	Belongs to the peptidase S11 family
IHV08_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
IHV08_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
IHV08_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IHV08_00100	COG1428	Deoxynucleoside kinase
IHV08_00105	COG1428	Deoxynucleoside kinase
IHV08_00110	COG1388	LysM domain
IHV08_00110	COG3858	chitin binding
IHV08_00115	COG1335	isochorismatase
IHV08_00120	COG0590	tRNA wobble adenosine to inosine editing
IHV08_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IHV08_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IHV08_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IHV08_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
IHV08_00190	COG3853	Toxic anion resistance protein (TelA)
IHV08_00195	COG1982	Orn Lys Arg decarboxylase major
IHV08_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IHV08_00205	COG3870	Protein conserved in bacteria
IHV08_00210	COG1728	Protein conserved in bacteria
IHV08_00215	COG0470	DNA polymerase III
IHV08_00220	COG1774	PSP1 C-terminal conserved region
IHV08_00225	COG4467	Involved in initiation control of chromosome replication
IHV08_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
IHV08_00235	COG2827	Endonuclease containing a URI domain
IHV08_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IHV08_00245	COG2002	toxin-antitoxin pair type II binding
IHV08_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IHV08_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IHV08_00255	COG0084	hydrolase, TatD family'
IHV08_00260	COG3584	3D domain protein
IHV08_00260	COG3583	domain protein
IHV08_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
IHV08_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
IHV08_00280	COG4466	Protein conserved in bacteria
IHV08_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
IHV08_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IHV08_00300	COG0251	oxidation-reduction process
IHV08_00305	COG2088	sporulation resulting in formation of a cellular spore
IHV08_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IHV08_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IHV08_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IHV08_00325	COG0193	aminoacyl-tRNA hydrolase activity
IHV08_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IHV08_00340	COG2002	toxin-antitoxin pair type II binding
IHV08_00345	COG2244	polysaccharide biosynthetic process
IHV08_00350	COG3956	TIGRFAM MazG family protein
IHV08_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IHV08_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
IHV08_00375	COG1098	S1 RNA binding domain
IHV08_00390	COG2208	phosphoserine phosphatase activity
IHV08_00395	COG2304	oxidoreductase activity
IHV08_00400	COG0515	serine threonine protein kinase
IHV08_00405	COG0037	tRNA processing
IHV08_00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
IHV08_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IHV08_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IHV08_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
IHV08_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IHV08_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IHV08_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IHV08_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
IHV08_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IHV08_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IHV08_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
IHV08_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IHV08_00470	COG1396	sequence-specific DNA binding
IHV08_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IHV08_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
IHV08_00560	COG4463	regulation of RNA biosynthetic process
IHV08_00565	COG3880	PFAM UvrB UvrC protein
IHV08_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
IHV08_00575	COG0542	response to heat
IHV08_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IHV08_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
IHV08_00590	COG4956	integral membrane protein (PIN domain superfamily)
IHV08_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IHV08_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IHV08_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IHV08_00610	COG1045	serine acetyltransferase
IHV08_00615	COG0215	cysteine-tRNA ligase activity
IHV08_00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
IHV08_00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IHV08_00630	COG3688	RNA-binding protein containing a PIN domain
IHV08_00635	COG1595	DNA-templated transcription, initiation
IHV08_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IHV08_00650	COG0250	Participates in transcription elongation, termination and antitermination
IHV08_00660	COG0081	regulation of translation
IHV08_00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IHV08_00675	COG2813	Specifically methylates the guanine in position
IHV08_00680	COG0085	RNA polymerase activity
IHV08_00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IHV08_00690	COG1358	cellular component organization or biogenesis
IHV08_00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IHV08_00700	COG0049	tRNA binding
IHV08_00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IHV08_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IHV08_00715	COG0596	Alpha beta hydrolase
IHV08_00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IHV08_00730	COG0088	Forms part of the polypeptide exit tunnel
IHV08_00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IHV08_00755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IHV08_00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IHV08_00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IHV08_00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IHV08_00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IHV08_00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IHV08_00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IHV08_00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IHV08_00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IHV08_00820	COG0200	Binds to the 23S rRNA
IHV08_00825	COG0201	protein transport
IHV08_00830	COG0563	adenylate kinase activity
IHV08_00835	COG0024	Methionine aminopeptidase
IHV08_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IHV08_00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IHV08_00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IHV08_00865	COG0202	RNA polymerase activity
IHV08_00870	COG0203	ribosomal protein L17
IHV08_00875	COG1122	ATPase activity
IHV08_00880	COG1122	ATPase activity
IHV08_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IHV08_00890	COG0101	tRNA pseudouridine synthase activity
IHV08_00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IHV08_00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IHV08_00905	COG2226	methyltransferase
IHV08_00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
IHV08_00920	COG0489	protein tyrosine kinase activity
IHV08_00930	COG2194	sulfuric ester hydrolase activity
IHV08_00935	COG0726	polysaccharide deacetylase
IHV08_01025	COG0659	secondary active sulfate transmembrane transporter activity
IHV08_01030	COG0385	Bile acid
IHV08_01035	COG2819	hydrolase of the alpha beta superfamily
IHV08_01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IHV08_01045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IHV08_01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IHV08_01055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IHV08_01055	COG2207	Transcriptional regulator
IHV08_01060	COG3876	Protein conserved in bacteria
IHV08_01065	COG1472	Belongs to the glycosyl hydrolase 3 family
IHV08_01070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IHV08_01075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IHV08_01075	COG1263	PTS System
IHV08_01080	COG1737	Transcriptional regulator
IHV08_01085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
IHV08_01090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IHV08_01095	COG1683	Conserved Protein
IHV08_01125	COG1595	DNA-templated transcription, initiation
IHV08_01130	COG5662	AntiSigma factor
IHV08_01135	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IHV08_01140	COG4856	YbbR-like protein
IHV08_01145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IHV08_01150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IHV08_01160	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IHV08_01165	COG2169	Transcriptional regulator
IHV08_01170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IHV08_01175	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IHV08_01180	COG3002	Belongs to the UPF0753 family
IHV08_01185	COG0288	reversible hydration of carbon dioxide
IHV08_01195	COG5609	conserved protein (DUF2294)
IHV08_01200	COG0640	Transcriptional regulator
IHV08_01205	COG2814	Major facilitator Superfamily
IHV08_01220	COG0596	Alpha beta hydrolase
IHV08_01225	COG0745	RESPONSE REGULATOR receiver
IHV08_01230	COG0642	Histidine kinase
IHV08_01240	COG0515	serine threonine protein kinase
IHV08_01255	COG1113	amino acid transport
IHV08_01270	COG2602	Beta-lactamase
IHV08_01275	COG2124	cytochrome p450
IHV08_01285	COG0531	amino acid
IHV08_01290	COG0584	glycerophosphoryl diester phosphodiesterase
IHV08_01295	COG2271	Major facilitator Superfamily
IHV08_01305	COG1846	Transcriptional regulator
IHV08_01305	COG0456	acetyltransferase
IHV08_01310	COG2271	Major facilitator Superfamily
IHV08_01315	COG0697	spore germination
IHV08_01320	COG1917	Cupin 2, conserved barrel domain protein
IHV08_01320	COG2207	Transcriptional regulator
IHV08_01325	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
IHV08_01330	COG3591	Belongs to the peptidase S1B family
IHV08_01340	COG0596	Alpha beta hydrolase
IHV08_01345	COG1183	phosphatidylcholine synthase activity
IHV08_01350	COG0586	Pfam SNARE associated Golgi protein
IHV08_01355	COG0688	phosphatidylethanolamine metabolic process
IHV08_01365	COG2312	Erythromycin esterase
IHV08_01370	COG2207	Transcriptional regulator
IHV08_01375	COG1054	Belongs to the UPF0176 family
IHV08_01380	COG1301	dicarboxylic acid transport
IHV08_01385	COG2190	(PTS) system
IHV08_01385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IHV08_01385	COG1263	PTS System
IHV08_01390	COG0363	glucosamine-6-phosphate deaminase activity
IHV08_01395	COG2188	Transcriptional regulator
IHV08_01405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IHV08_01410	COG0833	amino acid
IHV08_01415	COG2040	homocysteine
IHV08_01420	COG1115	amino acid carrier protein
IHV08_01425	COG2066	Belongs to the glutaminase family
IHV08_01430	COG4191	Histidine kinase
IHV08_01435	COG0784	Response regulator, receiver
IHV08_01440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IHV08_01445	COG1012	belongs to the aldehyde dehydrogenase family
IHV08_01450	COG2271	Major facilitator Superfamily
IHV08_01455	COG4948	Mandelate Racemase Muconate Lactonizing
IHV08_01460	COG2186	Transcriptional regulator
IHV08_01465	COG2721	sulfolactate sulfo-lyase activity
IHV08_01470	COG3173	Aminoglycoside phosphotransferase
IHV08_01480	COG0697	spore germination
IHV08_01485	COG0745	RESPONSE REGULATOR receiver
IHV08_01490	COG2205	protein histidine kinase activity
IHV08_01495	COG1131	(ABC) transporter
IHV08_01515	COG3773	Cell wall hydrolase
IHV08_01520	COG2304	oxidoreductase activity
IHV08_01530	COG3540	Alkaline phosphatase
IHV08_01535	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IHV08_01540	COG0805	protein transport
IHV08_01545	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
IHV08_01550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IHV08_01555	COG0477	Major facilitator Superfamily
IHV08_01560	COG1309	transcriptional regulator
IHV08_01565	COG0252	asparaginase activity
IHV08_01570	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
IHV08_01575	COG1714	RDD family
IHV08_01580	COG1405	negative regulation of cell septum assembly
IHV08_01580	COG3012	SEC-C Motif Domain Protein
IHV08_01585	COG3290	protein histidine kinase activity
IHV08_01590	COG3279	Response regulator of the LytR AlgR family
IHV08_01595	COG4555	ABC transporter
IHV08_01600	COG1668	transmembrane transport
IHV08_01605	COG0667	Aldo Keto reductase
IHV08_01620	COG1595	DNA-templated transcription, initiation
IHV08_01625	COG1595	DNA-templated transcription, initiation
IHV08_01630	COG1876	peptidase activity
IHV08_01635	COG0457	Tetratricopeptide repeat
IHV08_01640	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_01645	COG0366	Alpha amylase catalytic
IHV08_01650	COG0803	Belongs to the bacterial solute-binding protein 9 family
IHV08_01655	COG1121	(ABC) transporter
IHV08_01660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IHV08_01665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IHV08_01670	COG2310	stress, protein
IHV08_01675	COG2310	stress, protein
IHV08_01680	COG2310	stress, protein
IHV08_01685	COG0861	Integral membrane protein TerC family
IHV08_01695	COG3853	Toxic anion resistance protein (TelA)
IHV08_01700	COG0477	Major facilitator Superfamily
IHV08_01705	COG2814	Major facilitator Superfamily
IHV08_01710	COG0640	Transcriptional regulator
IHV08_01715	COG4175	Glycine betaine
IHV08_01715	COG0517	IMP dehydrogenase activity
IHV08_01720	COG4176	ABC-type proline glycine betaine transport system permease component
IHV08_01725	COG2113	Glycine betaine
IHV08_01730	COG1473	amidohydrolase
IHV08_01735	COG1288	antiporter activity
IHV08_01745	COG0366	Alpha amylase catalytic
IHV08_01750	COG0039	L-malate dehydrogenase activity
IHV08_01760	COG2814	Major facilitator Superfamily
IHV08_01765	COG1846	Transcriptional regulator
IHV08_01770	COG1280	lysine exporter protein (LysE YggA)
IHV08_01775	COG3403	YqcI/YcgG family
IHV08_01780	COG1113	amino acid transport
IHV08_01785	COG3665	Urea carboxylase-associated protein
IHV08_01790	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IHV08_01795	COG1660	Displays ATPase and GTPase activities
IHV08_01800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IHV08_01805	COG2226	methyltransferase
IHV08_01810	COG0583	DNA-binding transcription factor activity
IHV08_01815	COG3458	cephalosporin-C deacetylase activity
IHV08_01820	COG3541	Predicted nucleotidyltransferase
IHV08_01825	COG0506	proline dehydrogenase activity
IHV08_01830	COG1012	belongs to the aldehyde dehydrogenase family
IHV08_01835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IHV08_01840	COG2508	Transcriptional regulator
IHV08_01845	COG3689	TIGRFAM TIGR03943 family protein
IHV08_01850	COG0701	Predicted permease
IHV08_01855	COG2267	carboxylic ester hydrolase activity
IHV08_01860	COG0492	ferredoxin-NADP+ reductase activity
IHV08_01865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IHV08_01865	COG1587	Uroporphyrinogen-III synthase
IHV08_01870	COG2146	nitrite reductase [NAD(P)H] activity
IHV08_01875	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IHV08_01880	COG0243	molybdopterin cofactor binding
IHV08_01885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IHV08_01890	COG2223	nitrite transmembrane transporter activity
IHV08_01895	COG1469	GTP cyclohydrolase I activity
IHV08_01900	COG1376	ErfK ybiS ycfS ynhG family protein
IHV08_01910	COG0523	cobalamin synthesis protein
IHV08_01915	COG0765	amino acid transport
IHV08_01920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IHV08_01940	COG1846	Transcriptional regulator
IHV08_01955	COG2723	6-phospho-beta-galactosidase activity
IHV08_01965	COG3209	COG3209 Rhs family protein
IHV08_01970	COG3290	protein histidine kinase activity
IHV08_01970	COG0840	transmembrane signaling receptor activity
IHV08_01975	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IHV08_01980	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
IHV08_01985	COG1733	regulation of RNA biosynthetic process
IHV08_01990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IHV08_01995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IHV08_02000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IHV08_02005	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
IHV08_02010	COG2814	Major facilitator Superfamily
IHV08_02020	COG0697	spore germination
IHV08_02035	COG2364	Membrane
IHV08_02040	COG1126	abc transporter atp-binding protein
IHV08_02045	COG0765	amino acid transport
IHV08_02050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IHV08_02055	COG0583	DNA-binding transcription factor activity
IHV08_02060	COG0163	prenyltransferase activity
IHV08_02065	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IHV08_02080	COG0596	Alpha beta hydrolase
IHV08_02085	COG3104	oligopeptide transport
IHV08_02090	COG5434	Belongs to the glycosyl hydrolase 28 family
IHV08_02100	COG0697	spore germination
IHV08_02110	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IHV08_02115	COG1136	(ABC) transporter
IHV08_02120	COG0577	efflux transmembrane transporter activity
IHV08_02125	COG0745	RESPONSE REGULATOR receiver
IHV08_02130	COG3850	Histidine kinase
IHV08_02130	COG5002	protein histidine kinase activity
IHV08_02135	COG0457	Tetratricopeptide repeat
IHV08_02155	COG0527	aspartate kinase activity
IHV08_02160	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IHV08_02165	COG4605	iron ion homeostasis
IHV08_02170	COG4604	ABC transporter, ATP-binding protein
IHV08_02175	COG4607	ABC-type enterochelin transport system periplasmic component
IHV08_02180	COG2814	Major facilitator Superfamily
IHV08_02185	COG1309	transcriptional regulator
IHV08_02190	COG0778	Nitroreductase
IHV08_02195	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IHV08_02200	COG0640	Transcriptional regulator
IHV08_02205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IHV08_02210	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
IHV08_02215	COG1012	belongs to the aldehyde dehydrogenase family
IHV08_02220	COG4975	Glucose uptake
IHV08_02225	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_02230	COG4549	nuclear export factor GLE1
IHV08_02235	COG1276	copper resistance
IHV08_02235	COG2372	response to copper ion
IHV08_02240	COG1349	DNA-binding transcription factor activity
IHV08_02250	COG2213	PTS system mannitol-specific
IHV08_02255	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
IHV08_02260	COG0246	Mannitol dehydrogenase
IHV08_02265	COG0473	3-isopropylmalate dehydrogenase activity
IHV08_02270	COG0681	Belongs to the peptidase S26 family
IHV08_02275	COG0412	Dienelactone hydrolase
IHV08_02280	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IHV08_02290	COG0561	phosphatase activity
IHV08_02295	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IHV08_02300	COG1914	H( )-stimulated, divalent metal cation uptake system
IHV08_02305	COG4336	lyase activity
IHV08_02310	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IHV08_02315	COG1984	allophanate hydrolase subunit 2
IHV08_02320	COG1414	Transcriptional regulator
IHV08_02325	COG2755	lipolytic protein G-D-S-L family
IHV08_02335	COG2329	Antibiotic biosynthesis monooxygenase
IHV08_02340	COG0768	penicillin binding
IHV08_02345	COG4989	oxidoreductase activity
IHV08_02350	COG3711	transcriptional antiterminator
IHV08_02355	COG0318	PFAM AMP-dependent synthetase and ligase
IHV08_02360	COG2226	methyltransferase
IHV08_02365	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_02370	COG1917	Cupin 2, conserved barrel domain protein
IHV08_02375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IHV08_02380	COG3871	stress protein (general stress protein 26)
IHV08_02390	COG2814	Major facilitator Superfamily
IHV08_02395	COG1522	sequence-specific DNA binding
IHV08_02400	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IHV08_02400	COG0551	DNA topoisomerase type I activity
IHV08_02405	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
IHV08_02410	COG3706	GGDEF domain
IHV08_02415	COG5298	Protein conserved in bacteria
IHV08_02420	COG1215	transferase activity, transferring glycosyl groups
IHV08_02430	COG0531	amino acid
IHV08_02435	COG0494	nUDIX hydrolase
IHV08_02440	COG0028	Belongs to the TPP enzyme family
IHV08_02455	COG1914	H( )-stimulated, divalent metal cation uptake system
IHV08_02460	COG2261	transglycosylase associated protein
IHV08_02465	COG4876	unkown
IHV08_02470	COG2217	Heavy metal translocating P-type atpase
IHV08_02475	COG3729	General stress protein
IHV08_02480	COG0662	Cupin 2, conserved barrel domain protein
IHV08_02485	COG2329	Antibiotic biosynthesis monooxygenase
IHV08_02490	COG3546	catalase activity
IHV08_02495	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
IHV08_02500	COG3290	protein histidine kinase activity
IHV08_02505	COG4565	transcriptional regulatory protein
IHV08_02510	COG1301	dicarboxylic acid transport
IHV08_02515	COG0628	permease
IHV08_02520	COG1131	(ABC) transporter
IHV08_02525	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
IHV08_02535	COG1960	acyl-CoA dehydrogenase activity
IHV08_02550	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IHV08_02555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IHV08_02560	COG1181	Belongs to the D-alanine--D-alanine ligase family
IHV08_02565	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IHV08_02570	COG0513	Belongs to the DEAD box helicase family
IHV08_02575	COG3402	PFAM membrane-flanked domain
IHV08_02580	COG3428	Bacterial PH domain
IHV08_02585	COG0705	Rhomboid family
IHV08_02590	COG0736	holo-[acyl-carrier-protein] synthase activity
IHV08_02595	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IHV08_02600	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IHV08_02605	COG0864	Transcriptional regulator
IHV08_02610	COG2337	Toxic component of a toxin-antitoxin (TA) module
IHV08_02615	COG1366	Belongs to the anti-sigma-factor antagonist family
IHV08_02620	COG1366	Belongs to the anti-sigma-factor antagonist family
IHV08_02625	COG2172	sigma factor antagonist activity
IHV08_02630	COG2208	phosphoserine phosphatase activity
IHV08_02635	COG1366	Belongs to the anti-sigma-factor antagonist family
IHV08_02640	COG2172	sigma factor antagonist activity
IHV08_02645	COG1191	sigma factor activity
IHV08_02650	COG2208	phosphoserine phosphatase activity
IHV08_02665	COG1673	EVE domain
IHV08_02670	COG1846	Transcriptional regulator
IHV08_02675	COG2183	response to ionizing radiation
IHV08_02685	COG3091	SprT-like family
IHV08_02725	COG1476	TRANSCRIPTIONal
IHV08_02730	COG3239	Fatty acid desaturase
IHV08_02740	COG1278	Cold shock
IHV08_02745	COG1329	Transcriptional regulator
IHV08_02750	COG0697	spore germination
IHV08_02755	COG1917	Cupin 2, conserved barrel domain protein
IHV08_02755	COG2207	Transcriptional regulator
IHV08_02760	COG0697	spore germination
IHV08_02765	COG2207	Transcriptional regulator
IHV08_02765	COG3708	Transcriptional regulator
IHV08_02770	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IHV08_02775	COG0477	Major facilitator Superfamily
IHV08_02785	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
IHV08_02795	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IHV08_02800	COG1309	transcriptional regulator
IHV08_02805	COG0697	spore germination
IHV08_02810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IHV08_02815	COG2030	dehydratase
IHV08_02820	COG3545	Serine hydrolase
IHV08_02825	COG1733	regulation of RNA biosynthetic process
IHV08_02830	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IHV08_02835	COG1733	regulation of RNA biosynthetic process
IHV08_02840	COG2249	NAD(P)H dehydrogenase (quinone) activity
IHV08_02845	COG2814	Major facilitator Superfamily
IHV08_02850	COG1309	transcriptional regulator
IHV08_02855	COG0640	Transcriptional regulator
IHV08_02860	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IHV08_02870	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IHV08_02875	COG0697	spore germination
IHV08_02880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IHV08_02885	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IHV08_02890	COG0640	Transcriptional regulator
IHV08_02895	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IHV08_02910	COG4585	Histidine kinase
IHV08_02915	COG2197	response regulator
IHV08_02920	COG2409	Drug exporters of the RND superfamily
IHV08_02925	COG0596	Alpha beta hydrolase
IHV08_02930	COG1811	Na channel or pump
IHV08_02935	COG0789	Transcriptional regulator
IHV08_02935	COG4978	Transcriptional regulator
IHV08_02940	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IHV08_02945	COG0778	Nitroreductase
IHV08_02950	COG0346	lactoylglutathione lyase activity
IHV08_02955	COG2259	Doxx family
IHV08_02960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IHV08_02975	COG2323	membrane
IHV08_02980	COG2323	membrane
IHV08_02985	COG0071	Belongs to the small heat shock protein (HSP20) family
IHV08_03000	COG1309	transcriptional regulator
IHV08_03010	COG0456	acetyltransferase
IHV08_03015	COG0488	(ABC) transporter
IHV08_03020	COG1113	amino acid transport
IHV08_03025	COG2318	DinB family
IHV08_03030	COG1846	Transcriptional regulator
IHV08_03035	COG2409	Drug exporters of the RND superfamily
IHV08_03035	COG1033	growth of symbiont in host cell
IHV08_03040	COG0778	Nitroreductase
IHV08_03045	COG1846	Transcriptional regulator
IHV08_03050	COG2814	Major facilitator Superfamily
IHV08_03055	COG0730	response to heat
IHV08_03060	COG1802	Transcriptional regulator
IHV08_03065	COG3858	chitin binding
IHV08_03065	COG1388	LysM domain
IHV08_03070	COG1819	glycosyl
IHV08_03080	COG1785	Belongs to the alkaline phosphatase family
IHV08_03085	COG5646	InterPro IPR014922
IHV08_03095	COG0454	-acetyltransferase
IHV08_03100	COG1078	dGTPase activity
IHV08_03105	COG1388	LysM domain
IHV08_03110	COG2814	Major facilitator Superfamily
IHV08_03115	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IHV08_03120	COG1447	Phosphotransferase system cellobiose-specific component IIA
IHV08_03125	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IHV08_03130	COG2723	6-phospho-beta-galactosidase activity
IHV08_03135	COG2188	Transcriptional regulator
IHV08_03140	COG1940	carbohydrate kinase activity
IHV08_03145	COG1482	cell wall glycoprotein biosynthetic process
IHV08_03150	COG4124	Belongs to the glycosyl hydrolase 26 family
IHV08_03195	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IHV08_03200	COG0802	atpase or kinase
IHV08_03205	COG1214	PFAM Peptidase M22, glycoprotease
IHV08_03210	COG0456	acetyltransferase
IHV08_03215	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IHV08_03220	COG0488	(ABC) transporter
IHV08_03225	COG0315	cyclic pyranopterin monophosphate synthase activity
IHV08_03230	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
IHV08_03235	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IHV08_03240	COG0805	protein transport
IHV08_03250	COG1266	CAAX protease self-immunity
IHV08_03260	COG0459	protein refolding
IHV08_03265	COG4974	Belongs to the 'phage' integrase family
IHV08_03270	COG2856	Zn peptidase
IHV08_03285	COG1396	sequence-specific DNA binding
IHV08_03330	COG5377	YqaJ viral recombinase family
IHV08_03335	COG3723	Recombinational DNA repair protein, rece pathway
IHV08_03340	COG3935	DnaD domain protein
IHV08_03345	COG1484	DNA-dependent DNA replication
IHV08_03355	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
IHV08_03420	COG3677	Transposase
IHV08_03440	COG5484	DNA packaging
IHV08_03445	COG1783	phage Terminase large subunit
IHV08_03565	COG5632	N-Acetylmuramoyl-L-alanine amidase
IHV08_03565	COG1388	LysM domain
IHV08_03565	COG3409	Peptidoglycan-binding domain 1 protein
IHV08_03595	COG3409	Peptidoglycan-binding domain 1 protein
IHV08_03605	COG0457	Tetratricopeptide repeat
IHV08_03610	COG1063	alcohol dehydrogenase
IHV08_03615	COG2211	Major facilitator Superfamily
IHV08_03620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IHV08_03625	COG1842	Phage shock protein A
IHV08_03630	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IHV08_03635	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
IHV08_03640	COG4260	virion core protein, lumpy skin disease virus
IHV08_03650	COG2814	Major facilitator Superfamily
IHV08_03655	COG1063	alcohol dehydrogenase
IHV08_03660	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IHV08_03665	COG0823	Involved in the tonB-independent uptake of proteins
IHV08_03680	COG2267	carboxylic ester hydrolase activity
IHV08_03690	COG2132	Multicopper oxidase
IHV08_03695	COG1113	amino acid transport
IHV08_03705	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IHV08_03710	COG0714	Associated with various cellular activities
IHV08_03715	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
IHV08_03720	COG1305	Transglutaminase-like
IHV08_03725	COG0519	Catalyzes the synthesis of GMP from XMP
IHV08_03725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IHV08_03740	COG2252	PERMEase
IHV08_03745	COG3064	Membrane
IHV08_03755	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
IHV08_03765	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IHV08_03770	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
IHV08_03775	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IHV08_03780	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IHV08_03785	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IHV08_03790	COG0047	phosphoribosylformylglycinamidine synthase activity
IHV08_03795	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IHV08_03800	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IHV08_03805	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IHV08_03810	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IHV08_03815	COG0138	bifunctional purine biosynthesis protein purh
IHV08_03820	COG0151	Belongs to the GarS family
IHV08_03825	COG1522	sequence-specific DNA binding
IHV08_03830	COG0531	amino acid
IHV08_03840	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IHV08_03845	COG1470	cell adhesion involved in biofilm formation
IHV08_03850	COG4496	protein, YerC YecD
IHV08_03855	COG0069	glutamate synthase activity
IHV08_03860	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
IHV08_03865	COG0210	DNA helicase
IHV08_03870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IHV08_03875	COG4851	CamS sex pheromone cAM373 precursor
IHV08_03880	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IHV08_03885	COG1285	pathogenesis
IHV08_03890	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IHV08_03895	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IHV08_03900	COG0154	amidase activity
IHV08_03905	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IHV08_03910	COG1309	transcriptional regulator
IHV08_03915	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
IHV08_03920	COG1597	lipid kinase activity
IHV08_03925	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IHV08_03940	COG5444	nuclease activity
IHV08_03945	COG3391	amine dehydrogenase activity
IHV08_03960	COG0457	Tetratricopeptide repeat
IHV08_03970	COG0217	transcriptional regulatory protein
IHV08_03980	COG1309	transcriptional regulator
IHV08_03985	COG3631	Ketosteroid isomerase-related protein
IHV08_03990	COG0702	epimerase
IHV08_04005	COG3546	catalase activity
IHV08_04010	COG0454	-acetyltransferase
IHV08_04020	COG5578	integral membrane protein
IHV08_04025	COG2972	Histidine kinase
IHV08_04030	COG4753	response regulator
IHV08_04030	COG2207	Transcriptional regulator
IHV08_04035	COG1653	transport
IHV08_04040	COG1175	transmembrane transport
IHV08_04045	COG0395	ABC-type sugar transport system, permease component
IHV08_04050	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IHV08_04055	COG2207	Transcriptional regulator
IHV08_04060	COG2755	lipolytic protein G-D-S-L family
IHV08_04070	COG5578	integral membrane protein
IHV08_04075	COG3401	FG-GAP repeat protein
IHV08_04080	COG3401	FG-GAP repeat protein
IHV08_04085	COG2755	lipolytic protein G-D-S-L family
IHV08_04090	COG1874	Beta-galactosidase
IHV08_04100	COG1653	transport
IHV08_04105	COG4209	transmembrane transport
IHV08_04110	COG0395	ABC-type sugar transport system, permease component
IHV08_04115	COG1486	melibiose metabolic process
IHV08_04120	COG2323	membrane
IHV08_04125	COG2329	Antibiotic biosynthesis monooxygenase
IHV08_04130	COG0346	lactoylglutathione lyase activity
IHV08_04145	COG5583	Uncharacterized small protein (DUF2292)
IHV08_04150	COG0670	Belongs to the BI1 family
IHV08_04155	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IHV08_04170	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IHV08_04170	COG2124	cytochrome p450
IHV08_04175	COG1368	sulfuric ester hydrolase activity
IHV08_04180	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
IHV08_04185	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IHV08_04190	COG1442	glycosyl transferase family 8
IHV08_04195	COG1216	Glycosyl transferase, family 2
IHV08_04200	COG1442	glycosyl transferase family 8
IHV08_04205	COG2223	nitrite transmembrane transporter activity
IHV08_04210	COG1011	Hydrolase
IHV08_04215	COG0531	amino acid
IHV08_04220	COG1012	belongs to the aldehyde dehydrogenase family
IHV08_04225	COG0840	transmembrane signaling receptor activity
IHV08_04230	COG0488	(ABC) transporter
IHV08_04240	COG0789	Transcriptional regulator
IHV08_04245	COG2814	Major facilitator Superfamily
IHV08_04255	COG0488	(ABC) transporter
IHV08_04260	COG0513	Belongs to the DEAD box helicase family
IHV08_04265	COG0456	acetyltransferase
IHV08_04270	COG2130	NADP-dependent
IHV08_04275	COG2211	Major facilitator Superfamily
IHV08_04280	COG1262	PFAM Formylglycine-generating sulfatase enzyme
IHV08_04285	COG1120	ATPase activity
IHV08_04290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IHV08_04295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IHV08_04300	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
IHV08_04315	COG3866	Pectate lyase
IHV08_04320	COG0471	metal ion transport
IHV08_04325	COG3290	protein histidine kinase activity
IHV08_04330	COG4565	transcriptional regulatory protein
IHV08_04335	COG3181	Tripartite tricarboxylate transporter family receptor
IHV08_04340	COG2851	Citrate transporter
IHV08_04345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IHV08_04350	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
IHV08_04355	COG1254	Belongs to the acylphosphatase family
IHV08_04360	COG2258	MOSC domain
IHV08_04380	COG0024	Methionine aminopeptidase
IHV08_04385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IHV08_04385	COG1263	PTS System
IHV08_04390	COG1368	sulfuric ester hydrolase activity
IHV08_04405	COG1115	amino acid carrier protein
IHV08_04410	COG0531	amino acid
IHV08_04425	COG0697	spore germination
IHV08_04430	COG1263	PTS System
IHV08_04430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IHV08_04435	COG0366	Alpha amylase catalytic
IHV08_04440	COG2188	Transcriptional regulator
IHV08_04445	COG0778	Nitroreductase
IHV08_04450	COG0737	Belongs to the 5'-nucleotidase family
IHV08_04455	COG0693	protein deglycase activity
IHV08_04460	COG2814	Major facilitator Superfamily
IHV08_04465	COG4840	Belongs to the UPF0435 family
IHV08_04470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IHV08_04475	COG4980	gas vesicle protein
IHV08_04480	COG1295	ribonuclease BN
IHV08_04485	COG0477	Major facilitator Superfamily
IHV08_04490	COG0387	Pfam Sodium calcium exchanger
IHV08_04500	COG0668	transmembrane transport
IHV08_04505	COG0535	radical SAM domain protein
IHV08_04515	COG0726	polysaccharide deacetylase
IHV08_04520	COG2084	Dehydrogenase
IHV08_04525	COG0598	Magnesium transport protein CorA
IHV08_04530	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
IHV08_04535	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IHV08_04545	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IHV08_04550	COG4637	Psort location Cytoplasmic, score
IHV08_04560	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IHV08_04565	COG0022	dehydrogenase e1 component
IHV08_04570	COG0508	dehydrogenase complex catalyzes the overall conversion of
IHV08_04575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IHV08_04580	COG3284	Transcriptional regulator
IHV08_04590	COG1742	UPF0060 membrane protein
IHV08_04610	COG4842	Belongs to the WXG100 family
IHV08_04615	COG1486	melibiose metabolic process
IHV08_04620	COG1737	Transcriptional regulator
IHV08_04625	COG1263	PTS System
IHV08_04625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IHV08_04630	COG5434	Belongs to the glycosyl hydrolase 28 family
IHV08_04635	COG1132	(ABC) transporter
IHV08_04640	COG1132	(ABC) transporter
IHV08_04645	COG2259	Doxx family
IHV08_04650	COG2514	catechol 2,3-dioxygenase activity
IHV08_04655	COG4585	Histidine kinase
IHV08_04660	COG2197	response regulator
IHV08_04665	COG1131	(ABC) transporter
IHV08_04670	COG0842	Transport permease protein
IHV08_04670	COG1511	domain protein
IHV08_04675	COG0842	Transport permease protein
IHV08_04680	COG1695	Transcriptional regulator
IHV08_04685	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
IHV08_04690	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
IHV08_04695	COG2318	DinB family
IHV08_04700	COG2814	Major facilitator Superfamily
IHV08_04705	COG1846	Transcriptional regulator
IHV08_04710	COG0392	lysyltransferase activity
IHV08_04710	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
IHV08_04715	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IHV08_04720	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IHV08_04725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IHV08_04730	COG0384	phenazine biosynthesis protein PhzF
IHV08_04735	COG0778	Nitroreductase
IHV08_04750	COG1090	epimerase
IHV08_04755	COG2137	regulation of response to DNA damage stimulus
IHV08_04765	COG2814	Major facilitator Superfamily
IHV08_04780	COG3103	Sh3 type 3 domain protein
IHV08_04785	COG5658	integral membrane protein
IHV08_04790	COG0596	Alpha beta hydrolase
IHV08_04795	COG0463	Glycosyl transferase, family 2
IHV08_04800	COG4485	Bacterial membrane protein, YfhO
IHV08_04805	COG1988	membrane-bound metal-dependent
IHV08_04810	COG1194	a g-specific adenine glycosylase
IHV08_04820	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_04835	COG3557	Belongs to the UPF0374 family
IHV08_04840	COG1132	(ABC) transporter
IHV08_04845	COG4129	membrane
IHV08_04850	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IHV08_04855	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IHV08_04860	COG0735	belongs to the Fur family
IHV08_04970	COG4326	sporulation control protein
IHV08_04980	COG5577	PFAM Coat F domain
IHV08_04985	COG3340	Belongs to the peptidase S51 family
IHV08_04990	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IHV08_04995	COG0277	FAD linked oxidase domain protein
IHV08_05005	COG0753	catalase activity
IHV08_05010	COG1116	anion transmembrane transporter activity
IHV08_05015	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IHV08_05020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IHV08_05025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IHV08_05035	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IHV08_05045	COG1476	TRANSCRIPTIONal
IHV08_05055	COG3382	B3 4 domain protein
IHV08_05060	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IHV08_05070	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IHV08_05075	COG0789	Transcriptional regulator
IHV08_05080	COG1664	Polymer-forming cytoskeletal
IHV08_05085	COG1664	Polymer-forming cytoskeletal
IHV08_05090	COG2766	serine protein kinase
IHV08_05095	COG2718	Belongs to the UPF0229 family
IHV08_05100	COG1846	Transcriptional regulator
IHV08_05105	COG1566	PFAM secretion protein HlyD family protein
IHV08_05110	COG2814	Major facilitator Superfamily
IHV08_05115	COG0655	NAD(P)H dehydrogenase (quinone) activity
IHV08_05135	COG1725	Transcriptional regulator
IHV08_05140	COG1131	(ABC) transporter
IHV08_05145	COG1131	(ABC) transporter
IHV08_05150	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
IHV08_05155	COG1278	Cold shock
IHV08_05160	COG1464	Belongs to the NlpA lipoprotein family
IHV08_05165	COG3706	GGDEF domain
IHV08_05170	COG1823	symporter activity
IHV08_05190	COG5577	PFAM Coat F domain
IHV08_05200	COG3764	Sortase (surface protein transpeptidase)
IHV08_05205	COG0564	pseudouridine synthase activity
IHV08_05215	COG0517	IMP dehydrogenase activity
IHV08_05220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IHV08_05225	COG3153	acetyltransferase
IHV08_05225	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IHV08_05230	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IHV08_05235	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
IHV08_05240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
IHV08_05245	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
IHV08_05250	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
IHV08_05255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IHV08_05260	COG4585	Histidine kinase
IHV08_05260	COG2203	Gaf domain
IHV08_05265	COG2197	response regulator
IHV08_05270	COG0431	NADPH-dependent FMN reductase
IHV08_05285	COG0791	NLP P60 protein
IHV08_05285	COG1388	LysM domain
IHV08_05290	COG1959	2 iron, 2 sulfur cluster binding
IHV08_05295	COG0668	transmembrane transport
IHV08_05300	COG2719	SpoVR family
IHV08_05305	COG1785	Belongs to the alkaline phosphatase family
IHV08_05310	COG0791	NLP P60 protein
IHV08_05310	COG1388	LysM domain
IHV08_05315	COG0583	DNA-binding transcription factor activity
IHV08_05320	COG0372	Belongs to the citrate synthase family
IHV08_05325	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_05330	COG0531	amino acid
IHV08_05335	COG0733	neurotransmitter:sodium symporter activity
IHV08_05340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IHV08_05345	COG0456	acetyltransferase
IHV08_05360	COG1595	DNA-templated transcription, initiation
IHV08_05365	COG0667	Aldo Keto reductase
IHV08_05370	COG0204	Acyl-transferase
IHV08_05375	COG1253	flavin adenine dinucleotide binding
IHV08_05380	COG0789	Transcriptional regulator
IHV08_05385	COG0436	Aminotransferase
IHV08_05390	COG1253	flavin adenine dinucleotide binding
IHV08_05395	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IHV08_05400	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IHV08_05405	COG0584	glycerophosphoryl diester phosphodiesterase
IHV08_05415	COG0668	transmembrane transport
IHV08_05420	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
IHV08_05425	COG0726	polysaccharide deacetylase
IHV08_05430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IHV08_05435	COG1757	Na H antiporter
IHV08_05440	COG0589	response to stress
IHV08_05450	COG1132	(ABC) transporter
IHV08_05455	COG1132	(ABC) transporter
IHV08_05460	COG0702	epimerase
IHV08_05480	COG0189	ligase activity
IHV08_05485	COG0189	ligase activity
IHV08_05490	COG4399	Belongs to the UPF0754 family
IHV08_05495	COG3679	Belongs to the UPF0342 family
IHV08_05500	COG4335	DNA alkylation repair
IHV08_05505	COG0561	phosphatase activity
IHV08_05510	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IHV08_05515	COG0475	glutathione-regulated potassium exporter activity
IHV08_05520	COG0490	domain, Protein
IHV08_05530	COG1024	Enoyl-CoA hydratase
IHV08_05540	COG4152	abc transporter atp-binding protein
IHV08_05545	COG1668	transmembrane transport
IHV08_05550	COG0420	3'-5' exonuclease activity
IHV08_05555	COG4717	serine-type aminopeptidase activity
IHV08_05560	COG3481	metal-dependent phosphohydrolase, HD sub domain
IHV08_05570	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IHV08_05600	COG1846	Transcriptional regulator
IHV08_05605	COG4980	gas vesicle protein
IHV08_05620	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IHV08_05625	COG0537	adenosine 5'-monophosphoramidase activity
IHV08_05630	COG1131	(ABC) transporter
IHV08_05635	COG4473	ABC transporter
IHV08_05645	COG1473	amidohydrolase
IHV08_05650	COG3069	C4-dicarboxylate transmembrane transporter activity
IHV08_05660	COG2329	Antibiotic biosynthesis monooxygenase
IHV08_05665	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IHV08_05670	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IHV08_05675	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IHV08_05680	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
IHV08_05685	COG1309	transcriptional regulator
IHV08_05690	COG1511	domain protein
IHV08_05695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IHV08_05700	COG4377	Putative membrane peptidase family (DUF2324)
IHV08_05710	COG1363	Peptidase, m42
IHV08_05715	COG4405	Protein conserved in bacteria
IHV08_05720	COG1301	dicarboxylic acid transport
IHV08_05730	COG1234	tRNA 3'-trailer cleavage
IHV08_05735	COG0095	Lipoate-protein ligase
IHV08_05740	COG0702	epimerase
IHV08_05745	COG0318	PFAM AMP-dependent synthetase and ligase
IHV08_05755	COG0501	Belongs to the peptidase M48B family
IHV08_05765	COG0456	acetyltransferase
IHV08_05770	COG0604	alcohol dehydrogenase
IHV08_05775	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
IHV08_05780	COG0406	alpha-ribazole phosphatase activity
IHV08_05785	COG0183	Belongs to the thiolase family
IHV08_05790	COG0318	PFAM AMP-dependent synthetase and ligase
IHV08_05795	COG1268	BioY protein
IHV08_05800	COG0840	transmembrane signaling receptor activity
IHV08_05805	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IHV08_05805	COG0723	plastoquinol--plastocyanin reductase activity
IHV08_05810	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_05820	COG4903	ComK protein
IHV08_05825	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_05835	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IHV08_05850	COG0398	Pfam SNARE associated Golgi protein
IHV08_05855	COG0681	Belongs to the peptidase S26 family
IHV08_05860	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
IHV08_05865	COG1846	Transcriptional regulator
IHV08_05870	COG0738	Major facilitator superfamily
IHV08_05875	COG0673	inositol 2-dehydrogenase activity
IHV08_05880	COG0561	phosphatase activity
IHV08_05885	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IHV08_05890	COG1609	Transcriptional regulator
IHV08_05895	COG3180	Ammonia monooxygenase
IHV08_05900	COG0477	Major facilitator Superfamily
IHV08_05900	COG2814	Major facilitator Superfamily
IHV08_05905	COG4533	DNA binding
IHV08_05915	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
IHV08_05920	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
IHV08_05925	COG1074	ATP-dependent DNA helicase activity
IHV08_05930	COG0420	3'-5' exonuclease activity
IHV08_05935	COG0419	ATPase involved in DNA repair
IHV08_05940	COG1403	HNH endonuclease
IHV08_05980	COG5337	Spore coat protein CotH
IHV08_05985	COG0179	Fumarylacetoacetate (FAA) hydrolase
IHV08_05995	COG1404	Belongs to the peptidase S8 family
IHV08_06005	COG0367	asparagine synthase
IHV08_06010	COG2318	DinB family
IHV08_06015	COG1562	ergosterol biosynthetic process
IHV08_06020	COG0534	Mate efflux family protein
IHV08_06025	COG1917	Cupin 2, conserved barrel domain protein
IHV08_06025	COG2207	Transcriptional regulator
IHV08_06030	COG1609	Transcriptional regulator
IHV08_06035	COG0673	inositol 2-dehydrogenase activity
IHV08_06040	COG2318	DinB family
IHV08_06045	COG1279	arginine transmembrane transporter activity
IHV08_06050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
IHV08_06055	COG1357	PFAM Pentapeptide repeats (8 copies)
IHV08_06060	COG2267	carboxylic ester hydrolase activity
IHV08_06065	COG0529	Catalyzes the synthesis of activated sulfate
IHV08_06070	COG2046	Belongs to the sulfate adenylyltransferase family
IHV08_06075	COG0175	sulfate reduction
IHV08_06080	COG2045	Belongs to the ComB family
IHV08_06085	COG1809	phosphosulfolactate synthase activity
IHV08_06090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IHV08_06095	COG4948	Mandelate Racemase Muconate Lactonizing
IHV08_06100	COG2814	Major facilitator Superfamily
IHV08_06105	COG0454	-acetyltransferase
IHV08_06110	COG2153	protein acetylation
IHV08_06115	COG0646	methionine synthase
IHV08_06115	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IHV08_06120	COG1666	GTP binding
IHV08_06125	COG2996	Protein conserved in bacteria
IHV08_06145	COG1695	Transcriptional regulator
IHV08_06160	COG3227	Zinc metalloprotease (Elastase)
IHV08_06165	COG1307	EDD domain protein, DegV family
IHV08_06170	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IHV08_06190	COG0561	phosphatase activity
IHV08_06195	COG1073	alpha beta
IHV08_06200	COG2151	metal-sulfur cluster biosynthetic enzyme
IHV08_06210	COG0277	FAD linked oxidase domain protein
IHV08_06215	COG2271	Major facilitator Superfamily
IHV08_06220	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
IHV08_06225	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
IHV08_06235	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IHV08_06240	COG0505	Belongs to the CarA family
IHV08_06245	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IHV08_06250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IHV08_06265	COG2267	carboxylic ester hydrolase activity
IHV08_06275	COG1744	ABC transporter substrate-binding protein PnrA-like
IHV08_06290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IHV08_06295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IHV08_06300	COG5504	Zn-dependent protease
IHV08_06305	COG0444	Belongs to the ABC transporter superfamily
IHV08_06310	COG4608	Belongs to the ABC transporter superfamily
IHV08_06320	COG0601	transmembrane transport
IHV08_06325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IHV08_06335	COG0180	Tryptophanyl-tRNA synthetase
IHV08_06340	COG4166	transmembrane transport
IHV08_06345	COG0601	transmembrane transport
IHV08_06350	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IHV08_06355	COG0444	Belongs to the ABC transporter superfamily
IHV08_06360	COG4608	Belongs to the ABC transporter superfamily
IHV08_06365	COG2814	Major facilitator Superfamily
IHV08_06370	COG0456	acetyltransferase
IHV08_06375	COG1393	Belongs to the ArsC family
IHV08_06380	COG0861	Integral membrane protein TerC family
IHV08_06390	COG4862	establishment of competence for transformation
IHV08_06400	COG4469	Competence protein
IHV08_06405	COG1164	Oligoendopeptidase f
IHV08_06415	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IHV08_06420	COG2346	COG2346, Truncated hemoglobins
IHV08_06425	COG0741	lytic transglycosylase activity
IHV08_06430	COG4116	CYTH
IHV08_06440	COG2357	RelA SpoT domain protein
IHV08_06445	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IHV08_06450	COG0564	pseudouridine synthase activity
IHV08_06455	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
IHV08_06460	COG0475	glutathione-regulated potassium exporter activity
IHV08_06460	COG0569	domain protein
IHV08_06465	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IHV08_06470	COG0352	thiamine-phosphate diphosphorylase activity
IHV08_06475	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IHV08_06480	COG2104	thiamine diphosphate biosynthetic process
IHV08_06485	COG2022	thiamine diphosphate biosynthetic process
IHV08_06490	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IHV08_06495	COG0351	phosphomethylpyrimidine kinase
IHV08_06500	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IHV08_06555	COG0210	DNA helicase
IHV08_06565	COG2153	protein acetylation
IHV08_06570	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IHV08_06575	COG2382	esterase
IHV08_06580	COG0626	cystathionine gamma-synthase activity
IHV08_06585	COG0626	cystathionine gamma-synthase activity
IHV08_06590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IHV08_06595	COG5505	Protein of unknown function (DUF819)
IHV08_06615	COG5444	nuclease activity
IHV08_06640	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
IHV08_06645	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_06655	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IHV08_06655	COG3711	transcriptional antiterminator
IHV08_06660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IHV08_06660	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IHV08_06660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IHV08_06665	COG1482	cell wall glycoprotein biosynthetic process
IHV08_06675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IHV08_06685	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
IHV08_06700	COG0109	protoheme IX farnesyltransferase activity
IHV08_06710	COG0726	polysaccharide deacetylase
IHV08_06725	COG5504	Zn-dependent protease
IHV08_06730	COG2205	protein histidine kinase activity
IHV08_06740	COG3383	formate dehydrogenase (NAD+) activity
IHV08_06745	COG2427	Protein of unknown function (DUF1641)
IHV08_06755	COG1051	belongs to the nudix hydrolase family
IHV08_06770	COG1819	glycosyl
IHV08_06780	COG1587	Uroporphyrinogen-III synthase
IHV08_06785	COG0390	transport system, permease component
IHV08_06790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IHV08_06795	COG0697	spore germination
IHV08_06800	COG4297	protein containing double-stranded beta helix domain
IHV08_06810	COG1252	NADH dehydrogenase
IHV08_06815	COG1904	glucuronate isomerase
IHV08_06820	COG2211	Major facilitator Superfamily
IHV08_06825	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
IHV08_06830	COG1063	alcohol dehydrogenase
IHV08_06835	COG1312	Catalyzes the dehydration of D-mannonate
IHV08_06840	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_06845	COG2271	Major facilitator Superfamily
IHV08_06850	COG1609	Transcriptional regulator
IHV08_06855	COG0246	Mannitol dehydrogenase
IHV08_06860	COG2721	sulfolactate sulfo-lyase activity
IHV08_06865	COG0730	response to heat
IHV08_06870	COG2318	DinB family
IHV08_06875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IHV08_06880	COG0457	Tetratricopeptide repeat
IHV08_06890	COG2350	Protein conserved in bacteria
IHV08_06895	COG1388	LysM domain
IHV08_06895	COG5632	N-Acetylmuramoyl-L-alanine amidase
IHV08_06895	COG3409	Peptidoglycan-binding domain 1 protein
IHV08_06905	COG4195	phage-related replication protein
IHV08_06910	COG3546	catalase activity
IHV08_06915	COG2856	Zn peptidase
IHV08_06920	COG1396	sequence-specific DNA binding
IHV08_06930	COG1522	sequence-specific DNA binding
IHV08_06935	COG1484	DNA-dependent DNA replication
IHV08_06955	COG1595	DNA-templated transcription, initiation
IHV08_06960	COG3728	DNA packaging
IHV08_06960	COG5484	DNA packaging
IHV08_06965	COG1783	phage Terminase large subunit
IHV08_06970	COG5518	Phage portal protein
IHV08_06975	COG0338	D12 class N6 adenine-specific DNA methyltransferase
IHV08_06980	COG4653	Phage capsid family
IHV08_07030	COG3953	SLT domain
IHV08_07030	COG5412	phage tail tape measure protein
IHV08_07035	COG1652	LysM domain
IHV08_07040	COG4193	domain, Protein
IHV08_07050	COG3628	GPW Gp25 family protein
IHV08_07055	COG3299	homolog of phage Mu protein gp47
IHV08_07060	COG3778	Protein conserved in bacteria
IHV08_07100	COG3409	Peptidoglycan-binding domain 1 protein
IHV08_07100	COG5632	N-Acetylmuramoyl-L-alanine amidase
IHV08_07105	COG3594	Acyltransferase
IHV08_07125	COG0306	phosphate transporter
IHV08_07130	COG1392	Phosphate transport regulator
IHV08_07135	COG0531	amino acid
IHV08_07140	COG0346	lactoylglutathione lyase activity
IHV08_07150	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IHV08_07155	COG0463	Glycosyl transferase, family 2
IHV08_07160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IHV08_07165	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IHV08_07170	COG2362	D-Aminopeptidase
IHV08_07175	COG0601	transmembrane transport
IHV08_07180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IHV08_07185	COG0444	Belongs to the ABC transporter superfamily
IHV08_07190	COG4166	transmembrane transport
IHV08_07195	COG1619	proteins homologs of microcin C7 resistance protein MccF
IHV08_07200	COG4948	Mandelate Racemase Muconate Lactonizing
IHV08_07205	COG0791	NLP P60 protein
IHV08_07210	COG4608	Belongs to the ABC transporter superfamily
IHV08_07215	COG2706	6-phosphogluconolactonase activity
IHV08_07220	COG1834	amidinotransferase
IHV08_07225	COG1607	acyl-coa hydrolase
IHV08_07230	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
IHV08_07230	COG1017	nitric oxide dioxygenase activity
IHV08_07240	COG2323	membrane
IHV08_07245	COG2318	DinB family
IHV08_07250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IHV08_07255	COG2076	Multidrug Resistance protein
IHV08_07260	COG2076	Multidrug Resistance protein
IHV08_07265	COG0788	formyltetrahydrofolate deformylase activity
IHV08_07270	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IHV08_07275	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IHV08_07280	COG1764	response to oxidative stress
IHV08_07285	COG1846	Transcriptional regulator
IHV08_07290	COG1764	response to oxidative stress
IHV08_07300	COG0590	tRNA wobble adenosine to inosine editing
IHV08_07305	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IHV08_07310	COG1404	Belongs to the peptidase S8 family
IHV08_07315	COG1366	Belongs to the anti-sigma-factor antagonist family
IHV08_07320	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
IHV08_07325	COG1122	ATPase activity
IHV08_07330	COG4721	ABC-type cobalt transport system, permease component
IHV08_07340	COG0745	RESPONSE REGULATOR receiver
IHV08_07345	COG5002	protein histidine kinase activity
IHV08_07345	COG3850	Histidine kinase
IHV08_07350	COG3212	peptidase
IHV08_07355	COG3212	peptidase
IHV08_07365	COG2239	Acts as a magnesium transporter
IHV08_07370	COG0789	Transcriptional regulator
IHV08_07385	COG1846	Transcriptional regulator
IHV08_07390	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IHV08_07395	COG0726	polysaccharide deacetylase
IHV08_07400	COG1408	metallophosphoesterase
IHV08_07410	COG0463	Glycosyl transferase, family 2
IHV08_07415	COG3285	dna ligase
IHV08_07415	COG1793	dna ligase
IHV08_07420	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
IHV08_07425	COG3300	MHYT domain
IHV08_07425	COG5001	Diguanylate cyclase
IHV08_07430	COG0586	Pfam SNARE associated Golgi protein
IHV08_07435	COG0861	Integral membrane protein TerC family
IHV08_07440	COG1191	sigma factor activity
IHV08_07460	COG0501	Belongs to the peptidase M48B family
IHV08_07465	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IHV08_07480	COG3594	Acyltransferase
IHV08_07485	COG5002	protein histidine kinase activity
IHV08_07490	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IHV08_07500	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
IHV08_07505	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
IHV08_07510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
IHV08_07515	COG0436	Aminotransferase
IHV08_07520	COG1850	ribulose-bisphosphate carboxylase activity
IHV08_07525	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
IHV08_07530	COG0235	Class ii aldolase
IHV08_07535	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
IHV08_07540	COG3339	Conserved Protein
IHV08_07555	COG3852	Histidine kinase
IHV08_07560	COG1846	Transcriptional regulator
IHV08_07565	COG1360	Flagellar Motor Protein
IHV08_07570	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IHV08_07575	COG0542	response to heat
IHV08_07580	COG3949	Membrane
IHV08_07585	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IHV08_07590	COG0720	synthase
IHV08_07595	COG0602	queuosine metabolic process
IHV08_07600	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IHV08_07605	COG1733	regulation of RNA biosynthetic process
IHV08_07610	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_07615	COG1388	LysM domain
IHV08_07615	COG4641	Protein conserved in bacteria
IHV08_07620	COG1388	LysM domain
IHV08_07625	COG3858	chitin binding
IHV08_07635	COG4873	Protein conserved in bacteria
IHV08_07645	COG3773	Cell wall hydrolase
IHV08_07650	COG2244	polysaccharide biosynthetic process
IHV08_07655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IHV08_07660	COG2217	Heavy metal translocating P-type atpase
IHV08_07670	COG0006	proline dipeptidase activity
IHV08_07675	COG1609	Transcriptional regulator
IHV08_07680	COG3711	transcriptional antiterminator
IHV08_07685	COG2190	(PTS) system
IHV08_07685	COG1263	PTS System
IHV08_07685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IHV08_07690	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IHV08_07695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
IHV08_07705	COG1533	DNA photolyase activity
IHV08_07710	COG0456	acetyltransferase
IHV08_07715	COG0840	transmembrane signaling receptor activity
IHV08_07720	COG2084	Dehydrogenase
IHV08_07725	COG2340	Cysteine-rich secretory protein family
IHV08_07730	COG0768	penicillin binding
IHV08_07735	COG4191	Histidine kinase
IHV08_07740	COG0436	Aminotransferase
IHV08_07750	COG0835	chemotaxis
IHV08_07750	COG0784	Response regulator, receiver
IHV08_07760	COG2814	Major facilitator Superfamily
IHV08_07765	COG1376	ErfK ybiS ycfS ynhG family protein
IHV08_07770	COG1408	metallophosphoesterase
IHV08_07775	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_07780	COG2200	EAL domain
IHV08_07785	COG4703	Protein of unknown function (DUF1797)
IHV08_07790	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
IHV08_07800	COG0517	IMP dehydrogenase activity
IHV08_07805	COG0583	DNA-binding transcription factor activity
IHV08_07810	COG0716	FMN binding
IHV08_07820	COG0716	FMN binding
IHV08_07825	COG2171	N-acyltransferase activity
IHV08_07830	COG1473	amidohydrolase
IHV08_07840	COG0668	transmembrane transport
IHV08_07845	COG0450	alkyl hydroperoxide reductase
IHV08_07850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IHV08_07865	COG0746	molybdenum cofactor guanylyltransferase activity
IHV08_07870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
IHV08_07875	COG0303	'Molybdopterin
IHV08_07880	COG1763	Mo-molybdopterin cofactor biosynthetic process
IHV08_07885	COG0314	molybdopterin synthase activity
IHV08_07890	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
IHV08_07895	COG1132	(ABC) transporter
IHV08_07900	COG1132	(ABC) transporter
IHV08_07910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IHV08_07915	COG1136	(ABC) transporter
IHV08_07920	COG0577	efflux transmembrane transporter activity
IHV08_07925	COG1349	DNA-binding transcription factor activity
IHV08_07930	COG1105	Belongs to the carbohydrate kinase PfkB family
IHV08_07935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IHV08_07935	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IHV08_07935	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
IHV08_07940	COG0681	Belongs to the peptidase S26 family
IHV08_07950	COG0488	(ABC) transporter
IHV08_07955	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IHV08_07960	COG2309	aminopeptidase activity
IHV08_07970	COG1077	Cell shape determining protein MreB Mrl
IHV08_07975	COG2002	toxin-antitoxin pair type II binding
IHV08_07980	COG3852	Histidine kinase
IHV08_07985	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
IHV08_07985	COG2105	PFAM AIG2 family protein
IHV08_07990	COG0569	domain protein
IHV08_07995	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
IHV08_08000	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IHV08_08005	COG5503	Protein of unknown function (DUF1447)
IHV08_08010	COG0561	phosphatase activity
IHV08_08015	COG0242	peptide deformylase activity
IHV08_08025	COG0497	DNA recombination
IHV08_08030	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IHV08_08035	COG0022	dehydrogenase e1 component
IHV08_08040	COG0508	dehydrogenase complex catalyzes the overall conversion of
IHV08_08045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IHV08_08050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IHV08_08060	COG1982	Orn Lys Arg decarboxylase major
IHV08_08065	COG4476	Belongs to the UPF0223 family
IHV08_08070	COG4493	Belongs to the UPF0637 family
IHV08_08080	COG0483	inositol monophosphate 1-phosphatase activity
IHV08_08090	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
IHV08_08110	COG1595	DNA-templated transcription, initiation
IHV08_08130	COG1217	gtp-binding protein TYPA
IHV08_08140	COG4896	Protein conserved in bacteria
IHV08_08150	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
IHV08_08155	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IHV08_08160	COG2066	Belongs to the glutaminase family
IHV08_08165	COG4838	Belongs to the UPF0358 family
IHV08_08170	COG0772	Belongs to the SEDS family
IHV08_08175	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
IHV08_08180	COG1612	heme a metabolic process
IHV08_08185	COG0109	protoheme IX farnesyltransferase activity
IHV08_08190	COG2010	Cytochrome c
IHV08_08190	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IHV08_08195	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IHV08_08200	COG1845	cytochrome c oxidase, subunit III
IHV08_08205	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IHV08_08210	COG3336	cytochrome c oxidase
IHV08_08220	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
IHV08_08225	COG2340	Cysteine-rich secretory protein family
IHV08_08240	COG3679	Belongs to the UPF0342 family
IHV08_08245	COG4471	UPF0298 protein
IHV08_08250	COG0742	ribosomal rna small subunit methyltransferase
IHV08_08255	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IHV08_08260	COG3314	Sporulation integral membrane protein YlbJ
IHV08_08265	COG1752	Esterase of the alpha-beta hydrolase superfamily
IHV08_08270	COG3480	Lon protease (S16) C-terminal proteolytic domain
IHV08_08275	COG1323	Belongs to the UPF0348 family
IHV08_08285	COG1399	metal-binding, possibly nucleic acid-binding protein
IHV08_08300	COG0454	-acetyltransferase
IHV08_08305	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
IHV08_08310	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
IHV08_08315	COG2001	Belongs to the MraZ family
IHV08_08320	COG0275	rRNA processing
IHV08_08325	COG4839	cell division protein FtsL
IHV08_08330	COG0768	penicillin binding
IHV08_08335	COG0768	penicillin binding
IHV08_08340	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IHV08_08345	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IHV08_08350	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IHV08_08355	COG0772	Belongs to the SEDS family
IHV08_08360	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IHV08_08365	COG0812	UDP-N-acetylmuramate dehydrogenase activity
IHV08_08370	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
IHV08_08375	COG3879	Bacterial protein of unknown function (DUF881)
IHV08_08380	COG3879	Bacterial protein of unknown function (DUF881)
IHV08_08385	COG3856	small basic protein
IHV08_08390	COG0849	cell division
IHV08_08395	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IHV08_08410	COG1404	Belongs to the peptidase S8 family
IHV08_08410	COG4412	M6 family metalloprotease domain protein
IHV08_08420	COG1191	sigma factor activity
IHV08_08425	COG1191	sigma factor activity
IHV08_08430	COG1119	ATPase activity
IHV08_08435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IHV08_08440	COG1873	PFAM PRC-barrel domain
IHV08_08445	COG1496	oxidoreductase activity
IHV08_08450	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IHV08_08455	COG1799	cell septum assembly
IHV08_08460	COG0762	integral membrane protein
IHV08_08465	COG2302	S4 RNA-binding domain
IHV08_08470	COG3599	regulation of cell shape
IHV08_08475	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IHV08_08480	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IHV08_08485	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IHV08_08490	COG0564	pseudouridine synthase activity
IHV08_08495	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
IHV08_08500	COG2233	PERMEase
IHV08_08505	COG0540	Belongs to the ATCase OTCase family
IHV08_08510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IHV08_08515	COG0505	Belongs to the CarA family
IHV08_08520	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IHV08_08525	COG0543	2 iron, 2 sulfur cluster binding
IHV08_08530	COG0167	dihydroorotate dehydrogenase activity
IHV08_08535	COG0284	orotidine-5'-phosphate decarboxylase activity
IHV08_08540	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IHV08_08545	COG0175	sulfate reduction
IHV08_08550	COG0306	phosphate transporter
IHV08_08555	COG2046	Belongs to the sulfate adenylyltransferase family
IHV08_08560	COG0529	Catalyzes the synthesis of activated sulfate
IHV08_08565	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
IHV08_08570	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
IHV08_08575	COG1648	precorrin-2 dehydrogenase activity
IHV08_08580	COG1293	RNA-binding protein homologous to eukaryotic snRNP
IHV08_08585	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IHV08_08590	COG1561	YicC-like family, N-terminal region
IHV08_08600	COG0194	GDP metabolic process
IHV08_08605	COG1758	RNA polymerase activity
IHV08_08610	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IHV08_08615	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IHV08_08620	COG0242	peptide deformylase activity
IHV08_08625	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IHV08_08630	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IHV08_08630	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
IHV08_08635	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IHV08_08640	COG0631	protein serine/threonine phosphatase activity
IHV08_08645	COG0515	serine threonine protein kinase
IHV08_08645	COG2815	serine threonine protein kinase
IHV08_08650	COG1162	GTPase activity
IHV08_08655	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IHV08_08660	COG1564	THIamine pyrophosphokinase
IHV08_08670	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IHV08_08675	COG1302	Protein conserved in bacteria
IHV08_08680	COG1461	Dihydroxyacetone kinase
IHV08_08685	COG1760	l-serine dehydratase
IHV08_08690	COG1760	l-serine dehydratase
IHV08_08695	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IHV08_08700	COG2050	protein possibly involved in aromatic compounds catabolism
IHV08_08700	COG1349	DNA-binding transcription factor activity
IHV08_08705	COG0416	fatty acid biosynthetic process
IHV08_08710	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IHV08_08715	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_08725	COG0571	ribonuclease III activity
IHV08_08730	COG1196	nuclear chromosome segregation
IHV08_08735	COG0552	protein localization to endoplasmic reticulum
IHV08_08745	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
IHV08_08750	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IHV08_08755	COG0228	four-way junction DNA binding
IHV08_08760	COG1837	Belongs to the UPF0109 family
IHV08_08770	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IHV08_08775	COG0336	Belongs to the RNA methyltransferase TrmD family
IHV08_08780	COG0335	large ribosomal subunit rRNA binding
IHV08_08785	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IHV08_08790	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IHV08_08800	COG2257	FlhB HrpN YscU SpaS Family
IHV08_08805	COG0045	succinate-CoA ligase (ADP-forming) activity
IHV08_08810	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IHV08_08815	COG0758	DNA mediated transformation
IHV08_08820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IHV08_08825	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
IHV08_08830	COG4974	Belongs to the 'phage' integrase family
IHV08_08835	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IHV08_08840	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IHV08_08845	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
IHV08_08850	COG1815	bacterial-type flagellum-dependent cell motility
IHV08_08855	COG1558	bacterial-type flagellum-dependent cell motility
IHV08_08860	COG1677	Flagellar hook-basal body complex protein FliE
IHV08_08865	COG1766	The M ring may be actively involved in energy transduction
IHV08_08870	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IHV08_08875	COG1317	bacterial-type flagellum organization
IHV08_08880	COG1157	protein secretion by the type III secretion system
IHV08_08885	COG2882	bacterial-type flagellum organization
IHV08_08890	COG3334	PFAM MgtE intracellular
IHV08_08895	COG3144	bacterial-type flagellum assembly
IHV08_08900	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IHV08_08905	COG4786	Flagellar basal body rod
IHV08_08910	COG1582	Flagellar protein (FlbD)
IHV08_08915	COG1580	Controls the rotational direction of flagella during chemotaxis
IHV08_08920	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IHV08_08925	COG1776	CheC inhibitor of MCP methylation
IHV08_08925	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IHV08_08930	COG2201	protein-glutamate methylesterase activity
IHV08_08935	COG3190	flagellar
IHV08_08940	COG1338	Plays a role in the flagellum-specific transport system
IHV08_08945	COG1987	bacterial-type flagellum assembly
IHV08_08950	COG1684	flagellar biosynthetic protein fliR
IHV08_08955	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IHV08_08960	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IHV08_08965	COG1419	protein localization to endoplasmic reticulum
IHV08_08970	COG0455	bacterial-type flagellum organization
IHV08_08975	COG2201	protein-glutamate methylesterase activity
IHV08_08980	COG0643	Histidine kinase
IHV08_08980	COG2198	Histidine kinase
IHV08_08985	COG0835	chemotaxis
IHV08_08990	COG1776	CheC inhibitor of MCP methylation
IHV08_08995	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
IHV08_09000	COG1191	sigma factor activity
IHV08_09010	COG0052	Belongs to the universal ribosomal protein uS2 family
IHV08_09015	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IHV08_09020	COG0528	UMP kinase activity
IHV08_09025	COG0233	cytoplasmic translational termination
IHV08_09030	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
IHV08_09035	COG4589	Belongs to the CDS family
IHV08_09040	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IHV08_09045	COG0750	zinc metalloprotease
IHV08_09050	COG0442	prolyl-tRNA aminoacylation
IHV08_09055	COG2176	DNA-directed DNA polymerase activity
IHV08_09060	COG0779	Required for maturation of 30S ribosomal subunits
IHV08_09065	COG0195	Participates in both transcription termination and antitermination
IHV08_09070	COG2740	Nucleic-acid-binding protein implicated in transcription termination
IHV08_09075	COG1358	cellular component organization or biogenesis
IHV08_09080	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IHV08_09085	COG1550	Protein conserved in bacteria
IHV08_09090	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
IHV08_09095	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
IHV08_09100	COG0196	riboflavin kinase activity
IHV08_09105	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IHV08_09110	COG1185	polyribonucleotide nucleotidyltransferase activity
IHV08_09115	COG0726	polysaccharide deacetylase
IHV08_09120	COG0612	Peptidase, M16
IHV08_09125	COG1873	PFAM PRC-barrel domain
IHV08_09130	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IHV08_09135	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
IHV08_09140	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IHV08_09145	COG0527	aspartate kinase activity
IHV08_09150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IHV08_09155	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IHV08_09160	COG0740	serine-type endopeptidase activity
IHV08_09170	COG1674	ftsk spoiiie
IHV08_09170	COG4980	gas vesicle protein
IHV08_09175	COG2188	Transcriptional regulator
IHV08_09180	COG2814	Major facilitator Superfamily
IHV08_09185	COG0612	Peptidase, M16
IHV08_09190	COG0612	Peptidase, M16
IHV08_09195	COG0300	oxidoreductase activity
IHV08_09210	COG1426	Protein conserved in bacteria
IHV08_09215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
IHV08_09220	COG1546	Belongs to the CinA family
IHV08_09220	COG1058	Belongs to the CinA family
IHV08_09225	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IHV08_09230	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IHV08_09235	COG1418	mRNA catabolic process
IHV08_09240	COG1692	metallophosphoesterase
IHV08_09245	COG2359	stage V sporulation protein S
IHV08_09250	COG1063	alcohol dehydrogenase
IHV08_09255	COG0156	8-amino-7-oxononanoate synthase activity
IHV08_09260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IHV08_09265	COG4550	Control of competence regulator ComK, YlbF/YmcA
IHV08_09275	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
IHV08_09280	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
IHV08_09295	COG3226	Transcriptional regulator
IHV08_09300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IHV08_09310	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IHV08_09315	COG3321	synthase
IHV08_09320	COG2070	2-Nitropropane dioxygenase
IHV08_09320	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IHV08_09325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IHV08_09330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IHV08_09335	COG3425	synthase
IHV08_09340	COG1024	Enoyl-CoA hydratase
IHV08_09345	COG1024	Enoyl-CoA hydratase
IHV08_09350	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_09350	COG3321	synthase
IHV08_09350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IHV08_09350	COG0318	PFAM AMP-dependent synthetase and ligase
IHV08_09350	COG0300	oxidoreductase activity
IHV08_09355	COG4221	oxidoreductase activity
IHV08_09355	COG3321	synthase
IHV08_09355	COG0300	oxidoreductase activity
IHV08_09355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IHV08_09360	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_09360	COG3321	synthase
IHV08_09360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IHV08_09360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IHV08_09360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IHV08_09365	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_09365	COG4221	oxidoreductase activity
IHV08_09365	COG3321	synthase
IHV08_09365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IHV08_09370	COG3321	synthase
IHV08_09370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IHV08_09370	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
IHV08_09370	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
IHV08_09375	COG2124	cytochrome p450
IHV08_09385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IHV08_09390	COG1404	Belongs to the peptidase S8 family
IHV08_09400	COG4195	phage-related replication protein
IHV08_09405	COG1764	response to oxidative stress
IHV08_09410	COG2076	Multidrug Resistance protein
IHV08_09415	COG2076	Multidrug Resistance protein
IHV08_09430	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IHV08_09435	COG1923	regulation of RNA biosynthetic process
IHV08_09450	COG1780	Probably involved in ribonucleotide reductase function
IHV08_09455	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IHV08_09460	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IHV08_09465	COG4112	unkown
IHV08_09470	COG0860	N-Acetylmuramoyl-L-alanine amidase
IHV08_09475	COG0464	growth
IHV08_09480	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
IHV08_09485	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
IHV08_09490	COG0789	Transcriptional regulator
IHV08_09495	COG0174	glutamine synthetase
IHV08_09515	COG4282	regulation of fungal-type cell wall biogenesis
IHV08_09530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IHV08_09550	COG3655	Transcriptional regulator
IHV08_09580	COG2211	Major facilitator Superfamily
IHV08_09585	COG3507	Belongs to the glycosyl hydrolase 43 family
IHV08_09590	COG1940	carbohydrate kinase activity
IHV08_09595	COG2115	Belongs to the xylose isomerase family
IHV08_09600	COG1070	Carbohydrate kinase
IHV08_09610	COG1525	nuclease
IHV08_09615	COG2814	Major facilitator Superfamily
IHV08_09620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IHV08_09630	COG0756	dUTP diphosphatase activity
IHV08_09670	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IHV08_09685	COG3832	glyoxalase III activity
IHV08_09725	COG4195	phage-related replication protein
IHV08_09735	COG0346	lactoylglutathione lyase activity
IHV08_09740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
IHV08_09745	COG1388	LysM domain
IHV08_09750	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IHV08_09755	COG4224	UPF0291 protein
IHV08_09760	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IHV08_09770	COG3763	UPF0154 protein
IHV08_09780	COG0785	Cytochrome C biogenesis protein
IHV08_09785	COG2201	protein-glutamate methylesterase activity
IHV08_09790	COG4846	Membrane protein involved in cytochrome C biogenesis
IHV08_09800	COG0071	Belongs to the small heat shock protein (HSP20) family
IHV08_09815	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
IHV08_09820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IHV08_09840	COG0824	Thioesterase
IHV08_09850	COG4841	protein insertion into membrane
IHV08_09855	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IHV08_09860	COG1832	CoA-binding protein
IHV08_09865	COG0187	DNA topoisomerase II activity
IHV08_09870	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IHV08_09880	COG1115	amino acid carrier protein
IHV08_09885	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
IHV08_09895	COG5520	Belongs to the glycosyl hydrolase 30 family
IHV08_09900	COG3507	Belongs to the glycosyl hydrolase 43 family
IHV08_09905	COG2246	polysaccharide biosynthetic process
IHV08_09910	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IHV08_09915	COG0586	Pfam SNARE associated Golgi protein
IHV08_09920	COG2404	hydrolase activity, acting on ester bonds
IHV08_09925	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IHV08_09930	COG1024	Enoyl-CoA hydratase
IHV08_09935	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IHV08_09940	COG0511	ligase activity, forming carbon-carbon bonds
IHV08_09945	COG0439	Biotin carboxylase
IHV08_09950	COG0318	PFAM AMP-dependent synthetase and ligase
IHV08_09955	COG1960	acyl-CoA dehydrogenase activity
IHV08_09970	COG1649	PFAM Uncharacterised BCR, COG1649
IHV08_09980	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
IHV08_09980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IHV08_09985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IHV08_09990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IHV08_09995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IHV08_10000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IHV08_10010	COG2027	D-alanyl-D-alanine carboxypeptidase
IHV08_10015	COG2017	converts alpha-aldose to the beta-anomer
IHV08_10020	COG0534	Mate efflux family protein
IHV08_10035	COG0582	viral genome integration into host DNA
IHV08_10040	COG0166	Belongs to the GPI family
IHV08_10045	COG0405	Gamma-glutamyltransferase
IHV08_10050	COG0583	DNA-binding transcription factor activity
IHV08_10055	COG0604	alcohol dehydrogenase
IHV08_10060	COG0493	'glutamate synthase
IHV08_10065	COG0070	glutamate synthase
IHV08_10065	COG0067	glutamate synthase
IHV08_10065	COG0069	glutamate synthase activity
IHV08_10070	COG0583	DNA-binding transcription factor activity
IHV08_10075	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
IHV08_10080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IHV08_10090	COG0300	oxidoreductase activity
IHV08_10095	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
IHV08_10105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IHV08_10120	COG1131	(ABC) transporter
IHV08_10130	COG2814	Major facilitator Superfamily
IHV08_10135	COG1070	Carbohydrate kinase
IHV08_10140	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IHV08_10145	COG0243	molybdopterin cofactor binding
IHV08_10175	COG5278	phosphoserine phosphatase activity
IHV08_10175	COG0840	transmembrane signaling receptor activity
IHV08_10180	COG2368	4-hydroxyphenylacetate
IHV08_10185	COG4305	rare lipoprotein A
IHV08_10190	COG3619	membrane
IHV08_10195	COG3866	Pectate lyase
IHV08_10200	COG2135	peptidase activity
IHV08_10225	COG0456	acetyltransferase
IHV08_10245	COG2720	vancomycin resistance protein
IHV08_10260	COG3739	integral membrane protein
IHV08_10265	COG0583	DNA-binding transcription factor activity
IHV08_10270	COG0697	spore germination
IHV08_10280	COG0693	protein deglycase activity
IHV08_10285	COG2367	Beta-lactamase
IHV08_10305	COG0574	Belongs to the PEP-utilizing enzyme family
IHV08_10305	COG3848	Pyruvate phosphate dikinase
IHV08_10310	COG0726	polysaccharide deacetylase
IHV08_10315	COG1793	dna ligase
IHV08_10350	COG5444	nuclease activity
IHV08_10355	COG4282	regulation of fungal-type cell wall biogenesis
IHV08_10360	COG1231	oxidoreductase activity
IHV08_10365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IHV08_10370	COG2207	Transcriptional regulator
IHV08_10370	COG0662	Cupin 2, conserved barrel domain protein
IHV08_10375	COG0456	acetyltransferase
IHV08_10380	COG1309	transcriptional regulator
IHV08_10385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IHV08_10390	COG3708	Transcriptional regulator
IHV08_10395	COG2378	regulation of single-species biofilm formation
IHV08_10405	COG0640	Transcriptional regulator
IHV08_10410	COG0741	lytic transglycosylase activity
IHV08_10415	COG2322	membrane
IHV08_10430	COG1619	proteins homologs of microcin C7 resistance protein MccF
IHV08_10435	COG3239	Fatty acid desaturase
IHV08_10440	COG4585	Histidine kinase
IHV08_10445	COG2197	response regulator
IHV08_10450	COG1388	LysM domain
IHV08_10450	COG3584	3D domain protein
IHV08_10455	COG0514	ATP-dependent DNA helicase (RecQ)
IHV08_10465	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IHV08_10470	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IHV08_10485	COG0071	Belongs to the small heat shock protein (HSP20) family
IHV08_10510	COG1012	belongs to the aldehyde dehydrogenase family
IHV08_10515	COG1657	PFAM Prenyltransferase squalene oxidase
IHV08_10520	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IHV08_10525	COG0733	neurotransmitter:sodium symporter activity
IHV08_10530	COG0385	Bile acid
IHV08_10535	COG0508	dehydrogenase complex catalyzes the overall conversion of
IHV08_10540	COG0567	Dehydrogenase, E1 component
IHV08_10545	COG4548	von Willebrand factor, type A
IHV08_10550	COG0714	Associated with various cellular activities
IHV08_10555	COG2032	superoxide dismutase activity
IHV08_10560	COG1388	LysM domain
IHV08_10560	COG0791	NLP P60 protein
IHV08_10565	COG1819	glycosyl
IHV08_10570	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
IHV08_10575	COG0534	Mate efflux family protein
IHV08_10580	COG1366	Belongs to the anti-sigma-factor antagonist family
IHV08_10585	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IHV08_10590	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IHV08_10600	COG2962	Rard protein
IHV08_10620	COG1942	4-Oxalocrotonate Tautomerase
IHV08_10625	COG1733	regulation of RNA biosynthetic process
IHV08_10630	COG0778	Nitroreductase
IHV08_10635	COG0400	carboxylic ester hydrolase activity
IHV08_10640	COG0346	lactoylglutathione lyase activity
IHV08_10650	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IHV08_10655	COG3409	Peptidoglycan-binding domain 1 protein
IHV08_10655	COG0793	Belongs to the peptidase S41A family
IHV08_10660	COG2226	methyltransferase
IHV08_10670	COG1876	peptidase activity
IHV08_10675	COG0813	purine-nucleoside phosphorylase activity
IHV08_10690	COG0671	phosphoesterase, PA-phosphatase related
IHV08_10710	COG4479	Belongs to the UPF0346 family
IHV08_10720	COG1509	lysine 2,3-aminomutase activity
IHV08_10725	COG0456	acetyltransferase
IHV08_10730	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IHV08_10735	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IHV08_10740	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IHV08_10745	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IHV08_10760	COG0456	acetyltransferase
IHV08_10765	COG0463	Glycosyl transferase, family 2
IHV08_10780	COG4641	Protein conserved in bacteria
IHV08_10785	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
IHV08_10790	COG1086	Polysaccharide biosynthesis protein
IHV08_10800	COG3331	DNA recombination
IHV08_10825	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IHV08_10880	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
IHV08_10885	COG0756	dUTP diphosphatase activity
IHV08_10895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IHV08_10900	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IHV08_10905	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IHV08_10910	COG1780	Probably involved in ribonucleotide reductase function
IHV08_10995	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IHV08_11010	COG3584	3D domain protein
IHV08_11100	COG1395	domain, Protein
IHV08_11120	COG0776	regulation of translation
IHV08_11155	COG4373	Mu-like prophage FluMu protein gp28
IHV08_11245	COG0582	viral genome integration into host DNA
IHV08_11275	COG0741	lytic transglycosylase activity
IHV08_11275	COG0739	heme binding
IHV08_11275	COG1196	nuclear chromosome segregation
IHV08_11285	COG2433	Pfam Transposase IS66
IHV08_11310	COG5632	N-Acetylmuramoyl-L-alanine amidase
IHV08_11325	COG0457	Tetratricopeptide repeat
IHV08_11345	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IHV08_11375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IHV08_11395	COG5444	nuclease activity
IHV08_11400	COG4282	regulation of fungal-type cell wall biogenesis
IHV08_11415	COG1525	nuclease
IHV08_11430	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IHV08_11435	COG1086	Polysaccharide biosynthesis protein
IHV08_11440	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IHV08_11445	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IHV08_11450	COG1846	Transcriptional regulator
IHV08_11455	COG0534	Mate efflux family protein
IHV08_11465	COG4698	Protein conserved in bacteria
IHV08_11470	COG2755	lipolytic protein G-D-S-L family
IHV08_11475	COG1999	signal sequence binding
IHV08_11485	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IHV08_11490	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IHV08_11495	COG1272	protein, Hemolysin III
IHV08_11500	COG0204	Acyl-transferase
IHV08_11505	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IHV08_11510	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
IHV08_11515	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IHV08_11525	COG2521	methyltransferase
IHV08_11525	COG2136	Putative SAM-dependent methyltransferase
IHV08_11535	COG0129	dihydroxy-acid dehydratase activity
IHV08_11540	COG1413	lyase activity
IHV08_11545	COG1418	mRNA catabolic process
IHV08_11550	COG0386	Belongs to the glutathione peroxidase family
IHV08_11555	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IHV08_11560	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IHV08_11570	COG1278	Cold shock
IHV08_11590	COG0328	RNA-DNA hybrid ribonuclease activity
IHV08_11595	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
IHV08_11600	COG0328	RNA-DNA hybrid ribonuclease activity
IHV08_11610	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IHV08_11625	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IHV08_11635	COG1755	Isoprenylcysteine carboxyl methyltransferase
IHV08_11640	COG3424	synthase
IHV08_11645	COG2233	PERMEase
IHV08_11650	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IHV08_11655	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
IHV08_11665	COG0800	Aldolase
IHV08_11670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IHV08_11675	COG1609	Transcriptional regulator
IHV08_11680	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
IHV08_11685	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_11690	COG1199	ATP-dependent helicase activity
IHV08_11705	COG0116	Belongs to the methyltransferase superfamily
IHV08_11720	COG4474	Belongs to the UPF0398 family
IHV08_11735	COG3359	exonuclease
IHV08_11740	COG1205	dead DEAH box helicase
IHV08_11740	COG1111	helicase
IHV08_11745	COG2190	(PTS) system
IHV08_11750	COG0071	Belongs to the small heat shock protein (HSP20) family
IHV08_11785	COG3331	DNA recombination
IHV08_11790	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IHV08_11790	COG4499	WXG100 protein secretion system (Wss), protein YukC
IHV08_11800	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IHV08_11805	COG3935	DnaD domain protein
IHV08_11810	COG0017	Asparaginyl-tRNA synthetase
IHV08_11815	COG0436	Aminotransferase
IHV08_11820	COG5353	protein conserved in bacteria
IHV08_11830	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
IHV08_11830	COG1199	ATP-dependent helicase activity
IHV08_11835	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IHV08_11840	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IHV08_11845	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IHV08_11850	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IHV08_11850	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IHV08_11855	COG0617	tRNA 3'-terminal CCA addition
IHV08_11860	COG0438	transferase activity, transferring glycosyl groups
IHV08_11865	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
IHV08_11870	COG1803	Methylglyoxal synthase
IHV08_11875	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IHV08_11880	COG1694	Mazg nucleotide pyrophosphohydrolase
IHV08_11885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IHV08_11895	COG4347	Protein of unknown function (DUF1405)
IHV08_11900	COG2010	Cytochrome c
IHV08_11900	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IHV08_11905	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IHV08_11910	COG0723	plastoquinol--plastocyanin reductase activity
IHV08_11920	COG5582	Belongs to the UPF0302 family
IHV08_11925	COG0457	Tetratricopeptide repeat
IHV08_11930	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IHV08_11935	COG0287	Prephenate dehydrogenase
IHV08_11940	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IHV08_11945	COG0159	tryptophan synthase activity
IHV08_11950	COG0133	tryptophan synthase activity
IHV08_11955	COG0135	phosphoribosylanthranilate isomerase activity
IHV08_11965	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IHV08_11970	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IHV08_11975	COG4401	Chorismate mutase type I
IHV08_11980	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IHV08_11985	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IHV08_11990	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IHV08_11995	COG0105	UTP biosynthetic process
IHV08_12000	COG0142	geranyltranstransferase activity
IHV08_12005	COG2226	methyltransferase
IHV08_12010	COG0142	geranyltranstransferase activity
IHV08_12020	COG0302	gtp cyclohydrolase
IHV08_12025	COG0776	regulation of translation
IHV08_12030	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
IHV08_12045	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IHV08_12050	COG1160	GTP binding
IHV08_12075	COG1304	FMN binding
IHV08_12080	COG0539	negative regulation of cytoplasmic translation
IHV08_12085	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
IHV08_12095	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
IHV08_12100	COG2959	enzyme of heme biosynthesis
IHV08_12105	COG3409	Peptidoglycan-binding domain 1 protein
IHV08_12105	COG3773	Cell wall hydrolase
IHV08_12110	COG2339	peptidase activity
IHV08_12115	COG0492	ferredoxin-NADP+ reductase activity
IHV08_12120	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IHV08_12125	COG4862	establishment of competence for transformation
IHV08_12130	COG1408	metallophosphoesterase
IHV08_12140	COG1388	LysM domain
IHV08_12145	COG1266	CAAX protease self-immunity
IHV08_12150	COG0514	ATP-dependent DNA helicase (RecQ)
IHV08_12155	COG4955	Helix-turn-helix domain
IHV08_12160	COG1141	Ferredoxin
IHV08_12165	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
IHV08_12170	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IHV08_12175	COG0710	3-dehydroquinate dehydratase activity
IHV08_12185	COG1595	DNA-templated transcription, initiation
IHV08_12190	COG5002	protein histidine kinase activity
IHV08_12195	COG0745	RESPONSE REGULATOR receiver
IHV08_12200	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IHV08_12205	COG1333	cytochrome c biogenesis protein
IHV08_12210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IHV08_12215	COG1187	pseudouridine synthase activity
IHV08_12220	COG0700	Nucleoside recognition
IHV08_12225	COG2715	membrane protein required for spore maturation
IHV08_12230	COG1686	Belongs to the peptidase S11 family
IHV08_12240	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
IHV08_12245	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
IHV08_12250	COG1547	Domain of unknown function (DUF309)
IHV08_12255	COG0456	acetyltransferase
IHV08_12260	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IHV08_12265	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IHV08_12265	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IHV08_12270	COG0307	riboflavin synthase, alpha
IHV08_12275	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IHV08_12275	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IHV08_12285	COG0681	Belongs to the peptidase S26 family
IHV08_12295	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
IHV08_12320	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IHV08_12325	COG4086	secreted protein
IHV08_12330	COG0019	diaminopimelate decarboxylase activity
IHV08_12335	COG0697	spore germination
IHV08_12350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IHV08_12370	COG1191	sigma factor activity
IHV08_12375	COG2172	sigma factor antagonist activity
IHV08_12380	COG1366	Belongs to the anti-sigma-factor antagonist family
IHV08_12385	COG1686	Belongs to the peptidase S11 family
IHV08_12390	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
IHV08_12395	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
IHV08_12400	COG4974	Belongs to the 'phage' integrase family
IHV08_12410	COG0735	belongs to the Fur family
IHV08_12415	COG1300	Membrane
IHV08_12425	COG0281	malic enzyme
IHV08_12430	COG1757	Na H antiporter
IHV08_12435	COG1027	Aspartate ammonia-lyase
IHV08_12440	COG0252	asparaginase activity
IHV08_12445	COG1396	sequence-specific DNA binding
IHV08_12450	COG1379	DNA repair
IHV08_12455	COG0494	nUDIX hydrolase
IHV08_12465	COG0667	Aldo Keto reductase
IHV08_12475	COG1073	alpha beta
IHV08_12485	COG4918	Iron-sulphur cluster biosynthesis
IHV08_12490	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
IHV08_12490	COG0456	acetyltransferase
IHV08_12495	COG2329	Antibiotic biosynthesis monooxygenase
IHV08_12500	COG0456	acetyltransferase
IHV08_12510	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IHV08_12520	COG2211	Major facilitator Superfamily
IHV08_12530	COG0346	lactoylglutathione lyase activity
IHV08_12535	COG1072	(Pantothenic acid kinase))
IHV08_12540	COG3048	D-serine ammonia-lyase activity
IHV08_12545	COG0300	oxidoreductase activity
IHV08_12550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IHV08_12555	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IHV08_12560	COG4187	Peptidase family M20/M25/M40
IHV08_12565	COG1902	pentaerythritol trinitrate reductase activity
IHV08_12570	COG0596	Alpha beta hydrolase
IHV08_12580	COG1234	tRNA 3'-trailer cleavage
IHV08_12585	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
IHV08_12590	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IHV08_12595	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
IHV08_12605	COG0706	membrane insertase activity
IHV08_12610	COG3361	conserved protein (COG2071)
IHV08_12615	COG2195	Cleaves the N-terminal amino acid of tripeptides
IHV08_12620	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
IHV08_12625	COG0346	lactoylglutathione lyase activity
IHV08_12635	COG1376	ErfK ybiS ycfS ynhG family protein
IHV08_12640	COG4129	membrane
IHV08_12645	COG1126	abc transporter atp-binding protein
IHV08_12650	COG0765	amino acid transport
IHV08_12655	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IHV08_12665	COG1597	lipid kinase activity
IHV08_12670	COG2814	Major facilitator Superfamily
IHV08_12675	COG0789	Transcriptional regulator
IHV08_12675	COG4978	Transcriptional regulator
IHV08_12680	COG0508	dehydrogenase complex catalyzes the overall conversion of
IHV08_12685	COG0022	dehydrogenase e1 component
IHV08_12690	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
IHV08_12695	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
IHV08_12700	COG3426	butyrate kinase activity
IHV08_12705	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IHV08_12710	COG0280	phosphate acetyltransferase
IHV08_12715	COG3290	protein histidine kinase activity
IHV08_12715	COG3829	transcription factor binding
IHV08_12725	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
IHV08_12730	COG2079	MmgE PrpD family protein
IHV08_12735	COG0372	Belongs to the citrate synthase family
IHV08_12740	COG1960	acyl-CoA dehydrogenase activity
IHV08_12745	COG1250	3-hydroxyacyl-CoA dehydrogenase
IHV08_12750	COG0183	Belongs to the thiolase family
IHV08_12755	COG0584	glycerophosphoryl diester phosphodiesterase
IHV08_12760	COG0860	N-Acetylmuramoyl-L-alanine amidase
IHV08_12775	COG1902	pentaerythritol trinitrate reductase activity
IHV08_12780	COG0745	RESPONSE REGULATOR receiver
IHV08_12785	COG0750	zinc metalloprotease
IHV08_12790	COG0497	DNA recombination
IHV08_12795	COG1438	arginine binding
IHV08_12800	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
IHV08_12805	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IHV08_12810	COG0142	geranyltranstransferase activity
IHV08_12815	COG1722	exodeoxyribonuclease VII activity
IHV08_12820	COG1570	exodeoxyribonuclease VII activity
IHV08_12825	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IHV08_12830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IHV08_12835	COG1302	Protein conserved in bacteria
IHV08_12840	COG0439	Biotin carboxylase
IHV08_12845	COG0511	ligase activity, forming carbon-carbon bonds
IHV08_12885	COG3854	ATPases associated with a variety of cellular activities
IHV08_12895	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IHV08_12900	COG0006	proline dipeptidase activity
IHV08_12905	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IHV08_12915	COG3872	metal-dependent enzyme
IHV08_12925	COG1752	Esterase of the alpha-beta hydrolase superfamily
IHV08_12930	COG1321	iron dependent repressor
IHV08_12935	COG0095	Lipoate-protein ligase
IHV08_12940	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IHV08_12945	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IHV08_12950	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
IHV08_12955	COG0404	The glycine cleavage system catalyzes the degradation of glycine
IHV08_12960	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IHV08_12975	COG1396	sequence-specific DNA binding
IHV08_12985	COG0681	Belongs to the peptidase S26 family
IHV08_13010	COG4940	Competence protein ComGF
IHV08_13020	COG4970	Tfp pilus assembly protein FimT
IHV08_13025	COG4537	Required for transformation and DNA binding
IHV08_13030	COG1459	type II secretion system
IHV08_13035	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IHV08_13040	COG0598	Magnesium transport protein CorA
IHV08_13045	COG1253	flavin adenine dinucleotide binding
IHV08_13050	COG1366	Belongs to the anti-sigma-factor antagonist family
IHV08_13060	COG1393	Belongs to the ArsC family
IHV08_13070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IHV08_13080	COG0011	TIGRFAM Protein of
IHV08_13090	COG2866	Carboxypeptidase
IHV08_13095	COG1368	sulfuric ester hydrolase activity
IHV08_13100	COG1940	carbohydrate kinase activity
IHV08_13105	COG4483	Protein conserved in bacteria
IHV08_13110	COG0705	Rhomboid family
IHV08_13110	COG0457	Tetratricopeptide repeat
IHV08_13120	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
IHV08_13130	COG0438	transferase activity, transferring glycosyl groups
IHV08_13145	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IHV08_13150	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IHV08_13155	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
IHV08_13160	COG0581	inorganic phosphate transmembrane transporter activity
IHV08_13165	COG0573	inorganic phosphate transmembrane transporter activity
IHV08_13170	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IHV08_13175	COG0768	penicillin binding
IHV08_13180	COG0477	Major facilitator Superfamily
IHV08_13185	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IHV08_13190	COG2839	Protein conserved in bacteria
IHV08_13195	COG5521	maltodextrose utilization protein MalA
IHV08_13200	COG1388	LysM domain
IHV08_13205	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IHV08_13210	COG4709	membrane
IHV08_13215	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
IHV08_13220	COG0735	belongs to the Fur family
IHV08_13225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IHV08_13235	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
IHV08_13240	COG0513	Belongs to the DEAD box helicase family
IHV08_13250	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IHV08_13255	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IHV08_13260	COG2384	SAM-dependent methyltransferase
IHV08_13265	COG2010	Cytochrome c
IHV08_13270	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IHV08_13275	COG0358	DNA primase activity
IHV08_13280	COG1671	Belongs to the UPF0178 family
IHV08_13285	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
IHV08_13290	COG0517	IMP dehydrogenase activity
IHV08_13295	COG0751	glycine-tRNA ligase activity
IHV08_13300	COG0752	glycyl-tRNA synthetase alpha subunit
IHV08_13305	COG1381	Involved in DNA repair and RecF pathway recombination
IHV08_13315	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IHV08_13320	COG0295	cytidine deaminase activity
IHV08_13325	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IHV08_13330	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IHV08_13335	COG1480	7TM receptor with intracellular HD hydrolase
IHV08_13340	COG1702	phosphate starvation-inducible protein PhoH
IHV08_13345	COG0561	phosphatase activity
IHV08_13360	COG4864	UPF0365 protein
IHV08_13365	COG1030	water channel activity
IHV08_13370	COG1610	YqeY-like protein
IHV08_13380	COG1283	sodium-dependent phosphate transmembrane transporter activity
IHV08_13385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IHV08_13390	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IHV08_13395	COG2264	protein methyltransferase activity
IHV08_13400	COG0484	heat shock protein binding
IHV08_13405	COG0443	Heat shock 70 kDa protein
IHV08_13410	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
IHV08_13415	COG1420	regulation of RNA biosynthetic process
IHV08_13420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IHV08_13425	COG0481	GTPase activity
IHV08_13435	COG0860	N-Acetylmuramoyl-L-alanine amidase
IHV08_13440	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IHV08_13445	COG0268	Binds directly to 16S ribosomal RNA
IHV08_13450	COG1466	dna polymerase III delta subunit
IHV08_13465	COG2333	competence protein COMEC
IHV08_13465	COG0658	competence protein
IHV08_13470	COG2131	deaminase
IHV08_13475	COG1596	polysaccharide export
IHV08_13475	COG1555	photosystem II stabilization
IHV08_13480	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IHV08_13485	COG2226	methyltransferase
IHV08_13490	COG0799	negative regulation of ribosome biogenesis
IHV08_13495	COG1713	HD superfamily hydrolase involved in NAD metabolism
IHV08_13500	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IHV08_13505	COG1534	Rna-binding protein
IHV08_13510	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IHV08_13515	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
IHV08_13520	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
IHV08_13530	COG2755	lipolytic protein G-D-S-L family
IHV08_13535	COG3409	Peptidoglycan-binding domain 1 protein
IHV08_13535	COG5632	N-Acetylmuramoyl-L-alanine amidase
IHV08_13540	COG0398	Pfam SNARE associated Golgi protein
IHV08_13545	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
IHV08_13555	COG3209	COG3209 Rhs family protein
IHV08_13565	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
IHV08_13580	COG1802	Transcriptional regulator
IHV08_13585	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IHV08_13585	COG0473	3-isopropylmalate dehydrogenase activity
IHV08_13590	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IHV08_13590	COG0473	3-isopropylmalate dehydrogenase activity
IHV08_13595	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
IHV08_13605	COG4124	Belongs to the glycosyl hydrolase 26 family
IHV08_13610	COG0457	Tetratricopeptide repeat
IHV08_13625	COG5444	nuclease activity
IHV08_13655	COG5484	DNA packaging
IHV08_13720	COG0563	adenylate kinase activity
IHV08_13725	COG2856	Zn peptidase
IHV08_13745	COG4124	Belongs to the glycosyl hydrolase 26 family
IHV08_13750	COG0730	response to heat
IHV08_13755	COG0425	Belongs to the sulfur carrier protein TusA family
IHV08_13760	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IHV08_13760	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IHV08_13770	COG0425	Belongs to the sulfur carrier protein TusA family
IHV08_13770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IHV08_13775	COG2210	Belongs to the sulfur carrier protein TusA family
IHV08_13780	COG1937	Protein conserved in bacteria
IHV08_13785	COG0662	Cupin 2, conserved barrel domain protein
IHV08_13800	COG4978	Transcriptional regulator
IHV08_13800	COG0789	Transcriptional regulator
IHV08_13805	COG2814	Major facilitator Superfamily
IHV08_13810	COG0456	acetyltransferase
IHV08_13815	COG1253	flavin adenine dinucleotide binding
IHV08_13825	COG0697	spore germination
IHV08_13830	COG0583	DNA-binding transcription factor activity
IHV08_13835	COG2072	flavoprotein involved in K transport
IHV08_13840	COG1230	cation diffusion facilitator family transporter
IHV08_13845	COG1942	4-Oxalocrotonate Tautomerase
IHV08_13850	COG0583	DNA-binding transcription factor activity
IHV08_13860	COG1114	Component of the transport system for branched-chain amino acids
IHV08_13865	COG1687	branched-chain amino acid
IHV08_13870	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
IHV08_13875	COG1522	sequence-specific DNA binding
IHV08_13885	COG2124	cytochrome p450
IHV08_13895	COG1335	isochorismatase
IHV08_13915	COG2318	DinB family
IHV08_13925	COG2070	2-Nitropropane dioxygenase
IHV08_13930	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IHV08_13950	COG3443	Belongs to the bacterial solute-binding protein 9 family
IHV08_13955	COG1595	DNA-templated transcription, initiation
IHV08_13960	COG0667	Aldo Keto reductase
IHV08_13965	COG2851	Citrate transporter
IHV08_13970	COG0583	DNA-binding transcription factor activity
IHV08_13975	COG2828	Protein conserved in bacteria
IHV08_13980	COG3409	Peptidoglycan-binding domain 1 protein
IHV08_13985	COG5566	PFAM Mor transcription activator
IHV08_13990	COG0596	Alpha beta hydrolase
IHV08_13995	COG4991	sh3 domain protein
IHV08_14000	COG4991	sh3 domain protein
IHV08_14010	COG0346	lactoylglutathione lyase activity
IHV08_14020	COG5577	PFAM Coat F domain
IHV08_14025	COG1063	alcohol dehydrogenase
IHV08_14035	COG5577	PFAM Coat F domain
IHV08_14040	COG0789	Transcriptional regulator
IHV08_14050	COG1064	alcohol dehydrogenase
IHV08_14055	COG0693	protein deglycase activity
IHV08_14060	COG1621	beta-fructofuranosidase activity
IHV08_14065	COG3716	PTS system mannose fructose sorbose family IID component
IHV08_14070	COG3715	PTS system
IHV08_14075	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IHV08_14080	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
IHV08_14085	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
IHV08_14085	COG3933	PFAM sigma-54 factor interaction domain-containing protein
IHV08_14095	COG1113	amino acid transport
IHV08_14100	COG1280	lysine exporter protein (LysE YggA)
IHV08_14105	COG1378	Sugar-specific transcriptional regulator TrmB
IHV08_14110	COG1595	DNA-templated transcription, initiation
IHV08_14120	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
IHV08_14120	COG2755	lipolytic protein G-D-S-L family
IHV08_14130	COG2124	cytochrome p450
IHV08_14130	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IHV08_14135	COG1309	transcriptional regulator
IHV08_14140	COG2226	methyltransferase
IHV08_14155	COG2116	formate transmembrane transporter activity
IHV08_14160	COG5609	conserved protein (DUF2294)
IHV08_14165	COG3383	formate dehydrogenase (NAD+) activity
IHV08_14170	COG2427	Protein of unknown function (DUF1641)
IHV08_14180	COG0626	cystathionine gamma-synthase activity
IHV08_14185	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IHV08_14190	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IHV08_14195	COG2226	methyltransferase
IHV08_14210	COG0768	penicillin binding
IHV08_14215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IHV08_14220	COG0572	uridine kinase
IHV08_14225	COG0826	peptidase U32
IHV08_14230	COG0826	peptidase U32
IHV08_14235	COG4122	O-methyltransferase activity
IHV08_14240	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
IHV08_14245	COG3906	Belongs to the UPF0473 family
IHV08_14250	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IHV08_14255	COG4472	Bacterial protein of unknown function (DUF965)
IHV08_14260	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IHV08_14265	COG0628	permease
IHV08_14270	COG1126	abc transporter atp-binding protein
IHV08_14275	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IHV08_14280	COG0765	amino acid transport
IHV08_14285	COG0765	amino acid transport
IHV08_14300	COG3881	PFAM PRC-barrel domain
IHV08_14305	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IHV08_14310	COG0457	Tetratricopeptide repeat
IHV08_14315	COG0482	sulfurtransferase activity
IHV08_14320	COG1104	cysteine desulfurase activity
IHV08_14325	COG1959	2 iron, 2 sulfur cluster binding
IHV08_14330	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IHV08_14335	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
IHV08_14345	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IHV08_14350	COG0124	histidyl-tRNA synthetase
IHV08_14360	COG4991	sh3 domain protein
IHV08_14360	COG3103	Sh3 type 3 domain protein
IHV08_14360	COG0860	N-Acetylmuramoyl-L-alanine amidase
IHV08_14365	COG1490	D-aminoacyl-tRNA deacylase activity
IHV08_14370	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IHV08_14375	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IHV08_14380	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
IHV08_14380	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
IHV08_14385	COG5416	Lipopolysaccharide assembly protein A domain
IHV08_14390	COG0490	domain, Protein
IHV08_14395	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IHV08_14395	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IHV08_14405	COG2244	polysaccharide biosynthetic process
IHV08_14410	COG2323	membrane
IHV08_14420	COG1862	Preprotein translocase
IHV08_14425	COG0343	queuine tRNA-ribosyltransferase activity
IHV08_14430	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IHV08_14440	COG2255	four-way junction helicase activity
IHV08_14445	COG0632	four-way junction helicase activity
IHV08_14455	COG2814	Major facilitator Superfamily
IHV08_14460	COG0673	inositol 2-dehydrogenase activity
IHV08_14465	COG2112	serine threonine protein kinase
IHV08_14485	COG1115	amino acid carrier protein
IHV08_14490	COG0217	transcriptional regulatory protein
IHV08_14500	COG1388	LysM domain
IHV08_14505	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
IHV08_14510	COG0157	Belongs to the NadC ModD family
IHV08_14515	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
IHV08_14520	COG1104	cysteine desulfurase activity
IHV08_14525	COG1827	regulation of RNA biosynthetic process
IHV08_14530	COG0077	Prephenate dehydratase
IHV08_14535	COG4492	Belongs to the UPF0735 family
IHV08_14540	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IHV08_14545	COG3290	protein histidine kinase activity
IHV08_14555	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IHV08_14560	COG2868	ribosomal protein
IHV08_14565	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IHV08_14570	COG1994	Peptidase M50
IHV08_14575	COG0739	heme binding
IHV08_14580	COG2894	cell division
IHV08_14585	COG0850	regulation of cytokinetic process
IHV08_14590	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
IHV08_14600	COG1077	Cell shape determining protein MreB Mrl
IHV08_14605	COG2003	Belongs to the UPF0758 family
IHV08_14610	COG0424	maF-like protein
IHV08_14620	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
IHV08_14625	COG0285	dihydrofolate synthase activity
IHV08_14630	COG0525	valine-tRNA ligase activity
IHV08_14640	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IHV08_14645	COG1388	LysM domain
IHV08_14650	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IHV08_14655	COG0113	porphobilinogen synthase activity
IHV08_14660	COG1587	Uroporphyrinogen-III synthase
IHV08_14665	COG0181	hydroxymethylbilane synthase activity
IHV08_14670	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IHV08_14675	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IHV08_14685	COG0218	Necessary for normal cell division and for the maintenance of normal septation
IHV08_14690	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IHV08_14695	COG0470	DNA polymerase III
IHV08_14695	COG1067	ATP-dependent peptidase activity
IHV08_14700	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IHV08_14705	COG0544	peptidyl-prolyl cis-trans isomerase activity
IHV08_14710	COG1477	protein flavinylation
IHV08_14710	COG0457	Tetratricopeptide repeat
IHV08_14715	COG0066	3-isopropylmalate dehydratase activity
IHV08_14720	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IHV08_14725	COG0473	3-isopropylmalate dehydrogenase activity
IHV08_14730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IHV08_14735	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IHV08_14740	COG0440	acetolactate synthase activity
IHV08_14745	COG0028	Belongs to the TPP enzyme family
IHV08_14755	COG0454	-acetyltransferase
IHV08_14765	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
IHV08_14775	COG0622	Phosphoesterase
IHV08_14780	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IHV08_14785	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
IHV08_14790	COG5401	PFAM Sporulation and spore germination
IHV08_14795	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IHV08_14800	COG1846	Transcriptional regulator
IHV08_14805	COG2197	response regulator
IHV08_14810	COG0824	Thioesterase
IHV08_14815	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IHV08_14820	COG1053	succinate dehydrogenase
IHV08_14825	COG2009	succinate dehydrogenase
IHV08_14830	COG1719	4-vinyl reductase, 4VR
IHV08_14835	COG0527	aspartate kinase activity
IHV08_14840	COG0322	excinuclease ABC activity
IHV08_14845	COG3118	belongs to the thioredoxin family
IHV08_14850	COG3534	alpha-L-arabinofuranosidase
IHV08_14855	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
IHV08_14860	COG2086	electron transfer activity
IHV08_14865	COG1024	Enoyl-CoA hydratase
IHV08_14870	COG1309	transcriptional regulator
IHV08_14875	COG0318	PFAM AMP-dependent synthetase and ligase
IHV08_14880	COG3766	membrane
IHV08_14885	COG1193	negative regulation of DNA recombination
IHV08_14890	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IHV08_14890	COG1796	DNA polymerase
IHV08_14895	COG1286	toxin biosynthetic process
IHV08_14900	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
IHV08_14905	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IHV08_14910	COG0072	phenylalanine-tRNA ligase activity
IHV08_14910	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IHV08_14915	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IHV08_14925	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IHV08_14935	COG3835	regulator
IHV08_14940	COG0277	FAD linked oxidase domain protein
IHV08_14945	COG0247	lactate metabolic process
IHV08_14950	COG0346	lactoylglutathione lyase activity
IHV08_14955	COG1966	Carbon starvation protein
IHV08_14960	COG3534	alpha-L-arabinofuranosidase
IHV08_14965	COG0395	ABC-type sugar transport system, permease component
IHV08_14970	COG1175	transmembrane transport
IHV08_14975	COG1653	transport
IHV08_14980	COG0371	Dehydrogenase
IHV08_14985	COG0647	UMP catabolic process
IHV08_14990	COG0235	Class ii aldolase
IHV08_14995	COG1069	ribulokinase activity
IHV08_15000	COG2160	L-arabinose isomerase activity
IHV08_15005	COG3507	Belongs to the glycosyl hydrolase 43 family
IHV08_15010	COG1363	Peptidase, m42
IHV08_15020	COG3326	Membrane
IHV08_15025	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IHV08_15030	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IHV08_15035	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IHV08_15045	COG1346	cytolysis
IHV08_15050	COG1380	Effector of murein hydrolase LrgA
IHV08_15055	COG3279	Response regulator of the LytR AlgR family
IHV08_15060	COG3275	phosphorelay sensor kinase activity
IHV08_15065	COG1011	Hydrolase
IHV08_15070	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IHV08_15080	COG0398	Pfam SNARE associated Golgi protein
IHV08_15085	COG1484	DNA-dependent DNA replication
IHV08_15090	COG3611	Membrane attachment protein
IHV08_15095	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
IHV08_15100	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
IHV08_15105	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IHV08_15110	COG1733	regulation of RNA biosynthetic process
IHV08_15115	COG2814	Major facilitator Superfamily
IHV08_15120	COG0656	L-ascorbic acid biosynthetic process
IHV08_15125	COG0237	dephospho-CoA kinase activity
IHV08_15130	COG1971	Probably functions as a manganese efflux pump
IHV08_15135	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
IHV08_15140	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IHV08_15140	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
IHV08_15145	COG5002	protein histidine kinase activity
IHV08_15150	COG0745	RESPONSE REGULATOR receiver
IHV08_15155	COG0039	L-malate dehydrogenase activity
IHV08_15160	COG0538	isocitrate dehydrogenase activity
IHV08_15165	COG0372	Belongs to the citrate synthase family
IHV08_15170	COG2707	UPF0756 membrane protein
IHV08_15175	COG0628	permease
IHV08_15180	COG3030	protein affecting phage T7 exclusion by the F plasmid
IHV08_15185	COG0469	pyruvate kinase activity
IHV08_15190	COG0205	6-phosphofructokinase activity
IHV08_15195	COG0825	malonyl-CoA metabolic process
IHV08_15200	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IHV08_15205	COG0281	malic enzyme
IHV08_15210	COG0587	DNA-directed DNA polymerase activity
IHV08_15230	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
IHV08_15240	COG4109	DRTGG domain
IHV08_15245	COG0730	response to heat
IHV08_15250	COG1473	amidohydrolase
IHV08_15255	COG0196	riboflavin kinase activity
IHV08_15260	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IHV08_15265	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
IHV08_15270	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IHV08_15275	COG1126	abc transporter atp-binding protein
IHV08_15280	COG0765	amino acid transport
IHV08_15285	COG0765	amino acid transport
IHV08_15290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IHV08_15295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IHV08_15300	COG0454	-acetyltransferase
IHV08_15305	COG0583	DNA-binding transcription factor activity
IHV08_15310	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
IHV08_15315	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_15320	COG0165	Argininosuccinate lyase
IHV08_15325	COG0137	argininosuccinate synthase activity
IHV08_15330	COG0521	Mo-molybdopterin cofactor biosynthetic process
IHV08_15335	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
IHV08_15345	COG0827	DNA restriction-modification system
IHV08_15350	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IHV08_15355	COG3874	Sporulation protein YtfJ
IHV08_15365	COG1714	RDD family
IHV08_15370	COG0616	signal peptide processing
IHV08_15375	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IHV08_15380	COG1574	metal-dependent hydrolase with the TIM-barrel fold
IHV08_15385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IHV08_15395	COG0301	tRNA thio-modification
IHV08_15400	COG1104	cysteine desulfurase activity
IHV08_15405	COG1114	Component of the transport system for branched-chain amino acids
IHV08_15410	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
IHV08_15415	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
IHV08_15420	COG1309	transcriptional regulator
IHV08_15425	COG1956	GAF domain-containing protein
IHV08_15430	COG2203	Gaf domain
IHV08_15430	COG2199	diguanylate cyclase activity
IHV08_15435	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IHV08_15440	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IHV08_15445	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
IHV08_15450	COG0454	-acetyltransferase
IHV08_15455	COG0517	IMP dehydrogenase activity
IHV08_15460	COG0123	including yeast histone deacetylase and acetoin utilization protein
IHV08_15465	COG1360	Flagellar Motor Protein
IHV08_15470	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IHV08_15475	COG1609	Transcriptional regulator
IHV08_15480	COG1605	Chorismate mutase
IHV08_15480	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
IHV08_15485	COG3118	belongs to the thioredoxin family
IHV08_15490	COG4980	gas vesicle protein
IHV08_15495	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
IHV08_15500	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IHV08_15505	COG1674	ftsk spoiiie
IHV08_15510	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IHV08_15515	COG4848	Belongs to the UPF0354 family
IHV08_15520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IHV08_15535	COG1363	Peptidase, m42
IHV08_15540	COG5584	Small secreted protein
IHV08_15545	COG0281	malic enzyme
IHV08_15550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IHV08_15555	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IHV08_15565	COG0510	thiamine kinase activity
IHV08_15570	COG1523	belongs to the glycosyl hydrolase 13 family
IHV08_15575	COG1597	lipid kinase activity
IHV08_15585	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
IHV08_15590	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IHV08_15595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IHV08_15600	COG2252	PERMEase
IHV08_15605	COG4473	ABC transporter
IHV08_15610	COG1131	(ABC) transporter
IHV08_15615	COG1349	DNA-binding transcription factor activity
IHV08_15620	COG1187	pseudouridine synthase activity
IHV08_15625	COG2244	polysaccharide biosynthetic process
IHV08_15630	COG2081	HI0933 family
IHV08_15635	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
IHV08_15645	COG5578	integral membrane protein
IHV08_15650	COG0673	inositol 2-dehydrogenase activity
IHV08_15655	COG1653	transport
IHV08_15660	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
IHV08_15665	COG4209	transmembrane transport
IHV08_15670	COG2207	Transcriptional regulator
IHV08_15675	COG1653	transport
IHV08_15680	COG0395	ABC-type sugar transport system, permease component
IHV08_15685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IHV08_15690	COG2124	cytochrome p450
IHV08_15695	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IHV08_15705	COG0156	8-amino-7-oxononanoate synthase activity
IHV08_15710	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IHV08_15715	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
IHV08_15720	COG1073	alpha beta
IHV08_15725	COG1609	Transcriptional regulator
IHV08_15730	COG1653	transport
IHV08_15735	COG1175	transmembrane transport
IHV08_15740	COG0395	ABC-type sugar transport system, permease component
IHV08_15745	COG1486	melibiose metabolic process
IHV08_15750	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IHV08_15755	COG0495	leucyl-tRNA aminoacylation
IHV08_15765	COG1366	Belongs to the anti-sigma-factor antagonist family
IHV08_15765	COG2202	Pas domain
IHV08_15770	COG2814	Major facilitator Superfamily
IHV08_15775	COG2433	Pfam Transposase IS66
IHV08_15780	COG0577	efflux transmembrane transporter activity
IHV08_15785	COG1136	(ABC) transporter
IHV08_15790	COG2205	protein histidine kinase activity
IHV08_15795	COG0745	RESPONSE REGULATOR receiver
IHV08_15800	COG0577	efflux transmembrane transporter activity
IHV08_15805	COG1136	(ABC) transporter
IHV08_15820	COG1131	(ABC) transporter
IHV08_15825	COG1725	Transcriptional regulator
IHV08_15840	COG1242	4 iron, 4 sulfur cluster binding
IHV08_15845	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
IHV08_15855	COG2267	carboxylic ester hydrolase activity
IHV08_15860	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
IHV08_15865	COG1113	amino acid transport
IHV08_15870	COG0367	asparagine synthase
IHV08_15875	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IHV08_15880	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IHV08_15890	COG1506	peptidase
IHV08_15895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
IHV08_15900	COG1116	anion transmembrane transporter activity
IHV08_15905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
IHV08_15910	COG0494	nUDIX hydrolase
IHV08_15915	COG4824	toxin secretion phage lysis holin
IHV08_15920	COG0783	Belongs to the Dps family
IHV08_15935	COG1854	S-ribosylhomocysteine lyase activity
IHV08_15940	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IHV08_15945	COG0288	reversible hydration of carbon dioxide
IHV08_15950	COG0254	rRNA binding
IHV08_15955	COG1271	oxidase subunit
IHV08_15960	COG1294	oxidase, subunit
IHV08_15970	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IHV08_15975	COG1321	iron dependent repressor
IHV08_15975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IHV08_15980	COG1121	(ABC) transporter
IHV08_15985	COG0803	Belongs to the bacterial solute-binding protein 9 family
IHV08_15990	COG4948	Mandelate Racemase Muconate Lactonizing
IHV08_15995	COG0318	PFAM AMP-dependent synthetase and ligase
IHV08_16000	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
IHV08_16005	COG0596	Alpha beta hydrolase
IHV08_16010	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
IHV08_16015	COG1169	isochorismate synthase
IHV08_16020	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IHV08_16025	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IHV08_16030	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IHV08_16035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IHV08_16040	COG0438	transferase activity, transferring glycosyl groups
IHV08_16050	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IHV08_16055	COG0438	transferase activity, transferring glycosyl groups
IHV08_16060	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IHV08_16065	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
IHV08_16070	COG0058	SHG alpha-glucan phosphorylase activity
IHV08_16075	COG0297	glycogen (starch) synthase activity
IHV08_16080	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IHV08_16085	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
IHV08_16090	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
IHV08_16215	COG3859	Proton-coupled thiamine transporter YuaJ
IHV08_16220	COG1247	-acetyltransferase
IHV08_16225	COG2268	Band 7 protein
IHV08_16230	COG1585	Membrane protein implicated in regulation of membrane protease activity
IHV08_16235	COG2318	DinB family
IHV08_16245	COG1454	alcohol dehydrogenase
IHV08_16250	COG1012	belongs to the aldehyde dehydrogenase family
IHV08_16255	COG1510	regulation of RNA biosynthetic process
IHV08_16265	COG0569	domain protein
IHV08_16270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IHV08_16275	COG4682	membrane
IHV08_16280	COG1705	Flagellar rod assembly protein muramidase FlgJ
IHV08_16285	COG0477	Major facilitator Superfamily
IHV08_16290	COG5553	Cysteine dioxygenase type I
IHV08_16300	COG1968	undecaprenyl-diphosphatase activity
IHV08_16305	COG0628	permease
IHV08_16310	COG0673	inositol 2-dehydrogenase activity
IHV08_16315	COG4806	L-rhamnose isomerase
IHV08_16320	COG3254	rhamnose metabolic process
IHV08_16325	COG1070	Carbohydrate kinase
IHV08_16330	COG1349	DNA-binding transcription factor activity
IHV08_16335	COG3347	Dehydrogenase
IHV08_16335	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_16340	COG0840	transmembrane signaling receptor activity
IHV08_16345	COG0840	transmembrane signaling receptor activity
IHV08_16350	COG0840	transmembrane signaling receptor activity
IHV08_16355	COG0840	transmembrane signaling receptor activity
IHV08_16370	COG0432	Pfam Uncharacterised protein family UPF0047
IHV08_16380	COG0366	Alpha amylase catalytic
IHV08_16385	COG1253	flavin adenine dinucleotide binding
IHV08_16390	COG2738	Putative neutral zinc metallopeptidase
IHV08_16405	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IHV08_16420	COG0166	Belongs to the GPI family
IHV08_16425	COG1979	alcohol dehydrogenase
IHV08_16430	COG1979	alcohol dehydrogenase
IHV08_16435	COG2155	Conserved Protein
IHV08_16440	COG1098	S1 RNA binding domain
IHV08_16445	COG0436	Aminotransferase
IHV08_16450	COG1522	sequence-specific DNA binding
IHV08_16455	COG2267	carboxylic ester hydrolase activity
IHV08_16465	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
IHV08_16470	COG2205	protein histidine kinase activity
IHV08_16480	COG5018	Exonuclease
IHV08_16485	COG2814	Major facilitator Superfamily
IHV08_16490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IHV08_16495	COG3011	Protein conserved in bacteria
IHV08_16505	COG3290	protein histidine kinase activity
IHV08_16510	COG4565	transcriptional regulatory protein
IHV08_16515	COG1744	ABC transporter substrate-binding protein PnrA-like
IHV08_16520	COG3845	ABC transporter
IHV08_16525	COG4603	Belongs to the binding-protein-dependent transport system permease family
IHV08_16530	COG1079	Belongs to the binding-protein-dependent transport system permease family
IHV08_16535	COG3493	citrate carrier protein
IHV08_16545	COG2111	Na H antiporter
IHV08_16545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IHV08_16550	COG2111	Na H antiporter
IHV08_16555	COG1006	Multisubunit Na H antiporter MnhC subunit
IHV08_16560	COG0651	ATP synthesis coupled electron transport
IHV08_16565	COG1863	multisubunit Na H antiporter MnhE subunit
IHV08_16570	COG2212	antiporter activity
IHV08_16575	COG1320	monovalent cation:proton antiporter activity
IHV08_16580	COG2050	protein possibly involved in aromatic compounds catabolism
IHV08_16585	COG2197	response regulator
IHV08_16590	COG4585	Histidine kinase
IHV08_16600	COG0142	geranyltranstransferase activity
IHV08_16615	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
IHV08_16620	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
IHV08_16625	COG1335	isochorismatase
IHV08_16630	COG5506	Protein of unknown function (DUF1694)
IHV08_16645	COG0628	permease
IHV08_16660	COG1418	mRNA catabolic process
IHV08_16665	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_16675	COG1511	domain protein
IHV08_16680	COG0433	COG0433 Predicted ATPase
IHV08_16680	COG1674	ftsk spoiiie
IHV08_16685	COG4499	WXG100 protein secretion system (Wss), protein YukC
IHV08_16690	COG5417	Belongs to the EsaB family
IHV08_16695	COG4842	Belongs to the WXG100 family
IHV08_16700	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
IHV08_16700	COG2508	Transcriptional regulator
IHV08_16705	COG0686	Belongs to the AlaDH PNT family
IHV08_16710	COG5634	Uncharacterized conserved protein (DUF2278)
IHV08_16715	COG3251	PFAM MbtH domain protein
IHV08_16720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IHV08_16725	COG3433	isochorismatase activity
IHV08_16725	COG1535	isochorismatase
IHV08_16730	COG1021	2,3-dihydroxybenzoate-AMP ligase
IHV08_16735	COG1169	isochorismate synthase
IHV08_16740	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_16745	COG2819	hydrolase of the alpha beta superfamily
IHV08_16750	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IHV08_16755	COG1268	BioY protein
IHV08_16760	COG2056	Na+-H+ antiporter family
IHV08_16765	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IHV08_16770	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
IHV08_16775	COG3584	3D domain protein
IHV08_16790	COG1252	NADH dehydrogenase
IHV08_16795	COG0492	ferredoxin-NADP+ reductase activity
IHV08_16805	COG0516	GMP reductase activity
IHV08_16810	COG2808	Putative FMN-binding domain
IHV08_16815	COG0456	acetyltransferase
IHV08_16820	COG0316	Belongs to the HesB IscA family
IHV08_16825	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IHV08_16830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IHV08_16835	COG4844	belongs to the
IHV08_16840	COG1252	NADH dehydrogenase
IHV08_16845	COG4837	Protein of unknown function (DUF1462)
IHV08_16850	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
IHV08_16855	COG0823	Involved in the tonB-independent uptake of proteins
IHV08_16855	COG4946	Tricorn protease homolog
IHV08_16855	COG1506	peptidase
IHV08_16860	COG0083	homoserine kinase activity
IHV08_16865	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IHV08_16870	COG0460	homoserine dehydrogenase
IHV08_16875	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
IHV08_16880	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IHV08_16885	COG0647	UMP catabolic process
IHV08_16890	COG2445	Protein of unknown function DUF86
IHV08_16895	COG4470	Protein conserved in bacteria
IHV08_16905	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
IHV08_16910	COG0739	heme binding
IHV08_16920	COG3377	Domain of unknown function (DUF1805)
IHV08_16925	COG0737	Belongs to the 5'-nucleotidase family
IHV08_16930	COG0730	response to heat
IHV08_16935	COG1801	Protein of unknown function DUF72
IHV08_16945	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IHV08_16950	COG2508	Transcriptional regulator
IHV08_16955	COG2233	PERMEase
IHV08_16960	COG2233	PERMEase
IHV08_16965	COG3648	Uricase
IHV08_16965	COG3195	allantoin biosynthetic process
IHV08_16970	COG2351	hydroxyisourate hydrolase activity
IHV08_16980	COG2080	2 iron, 2 sulfur cluster binding
IHV08_16985	COG1529	Aldehyde oxidase and xanthine dehydrogenase
IHV08_16990	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
IHV08_16995	COG2068	MobA-Related Protein
IHV08_17000	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
IHV08_17005	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
IHV08_17010	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IHV08_17020	COG2356	endonuclease I
IHV08_17025	COG3842	ATPase activity
IHV08_17030	COG2188	Transcriptional regulator
IHV08_17035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IHV08_17040	COG0395	ABC-type sugar transport system, permease component
IHV08_17045	COG1175	transmembrane transport
IHV08_17050	COG1653	transport
IHV08_17055	COG2222	sugar isomerase
IHV08_17060	COG0322	excinuclease ABC activity
IHV08_17065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IHV08_17100	COG0457	Tetratricopeptide repeat
IHV08_17105	COG5444	nuclease activity
IHV08_17115	COG3409	Peptidoglycan-binding domain 1 protein
IHV08_17115	COG5632	N-Acetylmuramoyl-L-alanine amidase
IHV08_17115	COG1388	LysM domain
IHV08_17120	COG4824	toxin secretion phage lysis holin
IHV08_17155	COG3953	SLT domain
IHV08_17155	COG5412	phage tail tape measure protein
IHV08_17250	COG0305	Participates in initiation and elongation during chromosome replication
IHV08_17275	COG3645	SOS response
IHV08_17275	COG3646	Phage regulatory protein
IHV08_17305	COG1396	sequence-specific DNA binding
IHV08_17315	COG4974	Belongs to the 'phage' integrase family
IHV08_17320	COG0719	Fe-S assembly protein
IHV08_17325	COG0822	iron-sulfur transferase activity
IHV08_17330	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IHV08_17335	COG0719	Fe-S assembly protein
IHV08_17340	COG0396	ATPase activity
IHV08_17350	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
IHV08_17355	COG1464	Belongs to the NlpA lipoprotein family
IHV08_17360	COG2011	ABC-type metal ion transport system permease component
IHV08_17365	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IHV08_17375	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
IHV08_17380	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
IHV08_17390	COG0509	glycine decarboxylation via glycine cleavage system
IHV08_17395	COG1393	Belongs to the ArsC family
IHV08_17400	COG1960	acyl-CoA dehydrogenase activity
IHV08_17405	COG0183	Belongs to the thiolase family
IHV08_17410	COG1024	Enoyl-CoA hydratase
IHV08_17410	COG1250	3-hydroxyacyl-CoA dehydrogenase
IHV08_17420	COG0506	proline dehydrogenase activity
IHV08_17430	COG5577	PFAM Coat F domain
IHV08_17435	COG1846	Transcriptional regulator
IHV08_17440	COG0477	Major facilitator Superfamily
IHV08_17445	COG1942	4-Oxalocrotonate Tautomerase
IHV08_17450	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_17455	COG0583	DNA-binding transcription factor activity
IHV08_17465	COG1120	ATPase activity
IHV08_17480	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_17485	COG0783	Belongs to the Dps family
IHV08_17490	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IHV08_17495	COG0745	RESPONSE REGULATOR receiver
IHV08_17500	COG2770	Histidine kinase
IHV08_17500	COG2205	protein histidine kinase activity
IHV08_17510	COG1309	transcriptional regulator
IHV08_17515	COG0114	fumarate hydratase activity
IHV08_17525	COG0697	spore germination
IHV08_17530	COG0814	amino acid
IHV08_17540	COG2197	response regulator
IHV08_17545	COG4585	Histidine kinase
IHV08_17550	COG4758	membrane
IHV08_17555	COG3595	metallopeptidase activity
IHV08_17560	COG1842	Phage shock protein A
IHV08_17565	COG4758	membrane
IHV08_17570	COG2814	Major facilitator Superfamily
IHV08_17575	COG2096	Adenosyltransferase
IHV08_17580	COG1120	ATPase activity
IHV08_17585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IHV08_17590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IHV08_17595	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_17600	COG3386	PFAM SMP-30 Gluconolaconase
IHV08_17605	COG2205	protein histidine kinase activity
IHV08_17610	COG0745	RESPONSE REGULATOR receiver
IHV08_17620	COG1191	sigma factor activity
IHV08_17630	COG2140	Oxalate decarboxylase
IHV08_17640	COG0577	efflux transmembrane transporter activity
IHV08_17645	COG1136	(ABC) transporter
IHV08_17650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IHV08_17655	COG1120	ATPase activity
IHV08_17660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IHV08_17665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IHV08_17670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IHV08_17675	COG0531	amino acid
IHV08_17685	COG1988	membrane-bound metal-dependent
IHV08_17690	COG1368	sulfuric ester hydrolase activity
IHV08_17695	COG1910	domain protein
IHV08_17700	COG0725	ABC transporter, periplasmic molybdate-binding protein
IHV08_17705	COG4149	molybdate abc transporter
IHV08_17710	COG0656	L-ascorbic acid biosynthetic process
IHV08_17720	COG0025	NhaP-type Na H and K H
IHV08_17725	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
IHV08_17730	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
IHV08_17735	COG3973	AAA domain
IHV08_17745	COG2860	membrane
IHV08_17750	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IHV08_17755	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
IHV08_17760	COG2217	Heavy metal translocating P-type atpase
IHV08_17765	COG2217	Heavy metal translocating P-type atpase
IHV08_17770	COG2608	mercury ion transmembrane transporter activity
IHV08_17775	COG1937	Protein conserved in bacteria
IHV08_17780	COG0673	inositol 2-dehydrogenase activity
IHV08_17785	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
IHV08_17790	COG1289	transmembrane transporter activity
IHV08_17800	COG2076	Multidrug Resistance protein
IHV08_17805	COG1309	transcriptional regulator
IHV08_17810	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_17820	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IHV08_17825	COG0557	exoribonuclease II activity
IHV08_17830	COG1647	Serine aminopeptidase, S33
IHV08_17835	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IHV08_17840	COG0596	Alpha beta hydrolase
IHV08_17845	COG1476	TRANSCRIPTIONal
IHV08_17850	COG1396	sequence-specific DNA binding
IHV08_17855	COG1396	sequence-specific DNA binding
IHV08_17860	COG1733	regulation of RNA biosynthetic process
IHV08_17865	COG0840	transmembrane signaling receptor activity
IHV08_17870	COG1174	glycine betaine transport
IHV08_17875	COG1732	Glycine betaine
IHV08_17880	COG1174	glycine betaine transport
IHV08_17885	COG0517	IMP dehydrogenase activity
IHV08_17885	COG1125	glycine betaine transport
IHV08_17890	COG1510	regulation of RNA biosynthetic process
IHV08_17895	COG1174	glycine betaine transport
IHV08_17900	COG1732	Glycine betaine
IHV08_17905	COG1174	glycine betaine transport
IHV08_17910	COG0517	IMP dehydrogenase activity
IHV08_17910	COG1125	glycine betaine transport
IHV08_17915	COG1510	regulation of RNA biosynthetic process
IHV08_17920	COG2095	MarC family integral membrane protein
IHV08_17930	COG3064	Membrane
IHV08_17935	COG4640	response to antibiotic
IHV08_17940	COG0456	acetyltransferase
IHV08_17945	COG0148	phosphopyruvate hydratase activity
IHV08_17950	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IHV08_17955	COG0149	triose-phosphate isomerase activity
IHV08_17960	COG0126	phosphoglycerate kinase activity
IHV08_17965	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IHV08_17970	COG2390	Transcriptional regulator
IHV08_17975	COG2814	Major facilitator Superfamily
IHV08_17980	COG1609	Transcriptional regulator
IHV08_17985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IHV08_17990	COG0583	DNA-binding transcription factor activity
IHV08_17995	COG0697	spore germination
IHV08_18000	COG1113	amino acid transport
IHV08_18005	COG3858	chitin binding
IHV08_18010	COG1556	Lactate utilization protein
IHV08_18015	COG1139	Iron-sulfur cluster binding protein
IHV08_18020	COG0247	lactate metabolic process
IHV08_18025	COG2197	response regulator
IHV08_18030	COG4585	Histidine kinase
IHV08_18035	COG0842	Transport permease protein
IHV08_18040	COG1131	(ABC) transporter
IHV08_18045	COG0596	Alpha beta hydrolase
IHV08_18050	COG2208	phosphoserine phosphatase activity
IHV08_18055	COG3867	Arabinogalactan endo-beta-1,4-galactanase
IHV08_18060	COG1874	Beta-galactosidase
IHV08_18065	COG3833	ABC-type maltose transport systems, permease component
IHV08_18070	COG1175	transmembrane transport
IHV08_18075	COG2182	Extracellular solute-binding protein
IHV08_18080	COG1609	Transcriptional regulator
IHV08_18085	COG2186	Transcriptional regulator
IHV08_18090	COG1620	l-lactate permease
IHV08_18095	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IHV08_18105	COG5039	Polysaccharide pyruvyl transferase
IHV08_18110	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IHV08_18115	COG0110	maltose O-acetyltransferase activity
IHV08_18120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IHV08_18125	COG2244	polysaccharide biosynthetic process
IHV08_18130	COG1216	Glycosyl transferase, family 2
IHV08_18135	COG5039	Polysaccharide pyruvyl transferase
IHV08_18140	COG1216	Glycosyl transferase, family 2
IHV08_18150	COG0438	transferase activity, transferring glycosyl groups
IHV08_18155	COG1215	transferase activity, transferring glycosyl groups
IHV08_18160	COG0438	transferase activity, transferring glycosyl groups
IHV08_18165	COG1086	Polysaccharide biosynthesis protein
IHV08_18170	COG0489	protein tyrosine kinase activity
IHV08_18175	COG3944	biosynthesis protein
IHV08_18180	COG1396	sequence-specific DNA binding
IHV08_18185	COG2272	Belongs to the type-B carboxylesterase lipase family
IHV08_18195	COG3479	Phenolic acid decarboxylase
IHV08_18205	COG1794	racemase activity, acting on amino acids and derivatives
IHV08_18210	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
IHV08_18215	COG1621	beta-fructofuranosidase activity
IHV08_18220	COG1621	beta-fructofuranosidase activity
IHV08_18225	COG0531	amino acid
IHV08_18230	COG1309	transcriptional regulator
IHV08_18235	COG2076	Multidrug Resistance protein
IHV08_18240	COG2076	Multidrug Resistance protein
IHV08_18250	COG0277	FAD linked oxidase domain protein
IHV08_18255	COG3621	Patatin-like phospholipase
IHV08_18265	COG0740	serine-type endopeptidase activity
IHV08_18270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
IHV08_18275	COG0366	Alpha amylase catalytic
IHV08_18280	COG1554	hydrolase, family 65, central catalytic
IHV08_18285	COG5521	maltodextrose utilization protein MalA
IHV08_18290	COG3833	ABC-type maltose transport systems, permease component
IHV08_18295	COG1175	transmembrane transport
IHV08_18300	COG2182	Extracellular solute-binding protein
IHV08_18310	COG1609	Transcriptional regulator
IHV08_18315	COG1611	Belongs to the LOG family
IHV08_18320	COG1694	Mazg nucleotide pyrophosphohydrolase
IHV08_18325	COG0659	secondary active sulfate transmembrane transporter activity
IHV08_18330	COG0288	reversible hydration of carbon dioxide
IHV08_18335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IHV08_18340	COG0577	efflux transmembrane transporter activity
IHV08_18345	COG1136	(ABC) transporter
IHV08_18350	COG5002	protein histidine kinase activity
IHV08_18355	COG0745	RESPONSE REGULATOR receiver
IHV08_18365	COG2162	N-hydroxyarylamine O-acetyltransferase activity
IHV08_18370	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
IHV08_18375	COG1481	regulation of sporulation
IHV08_18380	COG0391	Required for morphogenesis under gluconeogenic growth conditions
IHV08_18385	COG1660	Displays ATPase and GTPase activities
IHV08_18390	COG1051	belongs to the nudix hydrolase family
IHV08_18395	COG0492	ferredoxin-NADP+ reductase activity
IHV08_18400	COG3883	PFAM NLP P60 protein
IHV08_18400	COG0791	NLP P60 protein
IHV08_18405	COG0457	Tetratricopeptide repeat
IHV08_18410	COG1132	(ABC) transporter
IHV08_18445	COG0140	phosphoribosyl-ATP diphosphatase activity
IHV08_18445	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IHV08_18450	COG0107	imidazoleglycerol-phosphate synthase activity
IHV08_18455	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IHV08_18460	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IHV08_18465	COG0131	Imidazoleglycerol-phosphate dehydratase
IHV08_18470	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
IHV08_18475	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IHV08_18480	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
IHV08_18485	COG4990	cell redox homeostasis
IHV08_18490	COG5297	Belongs to the glycosyl hydrolase family 6
IHV08_18495	COG0110	maltose O-acetyltransferase activity
IHV08_18500	COG0546	phosphoglycolate phosphatase activity
IHV08_18505	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
IHV08_18510	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
IHV08_18515	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
IHV08_18520	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
IHV08_18525	COG0363	glucosamine-6-phosphate deaminase activity
IHV08_18530	COG2188	Transcriptional regulator
IHV08_18535	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
IHV08_18540	COG1846	Transcriptional regulator
IHV08_18545	COG2124	cytochrome p450
IHV08_18555	COG1846	Transcriptional regulator
IHV08_18560	COG2814	Major facilitator Superfamily
IHV08_18565	COG1950	PFAM Membrane protein of
IHV08_18570	COG1983	PspC domain protein
IHV08_18575	COG3595	metallopeptidase activity
IHV08_18590	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IHV08_18595	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IHV08_18600	COG0556	nucleotide-excision repair
IHV08_18605	COG4897	Protein conserved in bacteria
IHV08_18610	COG3848	Pyruvate phosphate dikinase
IHV08_18610	COG0574	Belongs to the PEP-utilizing enzyme family
IHV08_18615	COG1309	transcriptional regulator
IHV08_18620	COG2814	Major facilitator Superfamily
IHV08_18625	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IHV08_18635	COG3409	Peptidoglycan-binding domain 1 protein
IHV08_18635	COG0793	Belongs to the peptidase S41A family
IHV08_18640	COG2177	Part of the ABC transporter FtsEX involved in
IHV08_18645	COG2884	Cell division ATP-binding protein ftsE
IHV08_18650	COG2010	Cytochrome c
IHV08_18655	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IHV08_18665	COG0653	protein targeting
IHV08_18670	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
IHV08_18685	COG1516	flagellar protein fliS
IHV08_18690	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IHV08_18695	COG1334	flagellar protein FlaG
IHV08_18700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IHV08_18705	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
IHV08_18710	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
IHV08_18720	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IHV08_18725	COG4786	Flagellar basal body rod
IHV08_18725	COG1256	bacterial-type flagellum assembly
IHV08_18730	COG3418	PFAM FlgN family protein
IHV08_18735	COG2747	anti-sigma28 factor FlgM
IHV08_18745	COG1040	competence protein
IHV08_18755	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
IHV08_18760	COG1307	EDD domain protein, DegV family
IHV08_18765	COG2197	response regulator
IHV08_18770	COG4585	Histidine kinase
IHV08_18775	COG1739	Uncharacterized protein family UPF0029
IHV08_18780	COG1316	TRANSCRIPTIONal
IHV08_18785	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IHV08_18790	COG0438	transferase activity, transferring glycosyl groups
IHV08_18795	COG1215	transferase activity, transferring glycosyl groups
IHV08_18800	COG3206	protein involved in exopolysaccharide biosynthesis
IHV08_18805	COG3307	-O-antigen
IHV08_18810	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IHV08_18815	COG0297	glycogen (starch) synthase activity
IHV08_18815	COG0438	transferase activity, transferring glycosyl groups
IHV08_18820	COG2244	polysaccharide biosynthetic process
IHV08_18835	COG0860	N-Acetylmuramoyl-L-alanine amidase
IHV08_18835	COG2247	cell wall binding repeat
IHV08_18840	COG2247	cell wall binding repeat
IHV08_18840	COG2385	sporulation resulting in formation of a cellular spore
IHV08_18850	COG1316	TRANSCRIPTIONal
IHV08_18855	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
IHV08_18875	COG1210	Utp--glucose-1-phosphate uridylyltransferase
IHV08_18880	COG1134	teichoic acid transport
IHV08_18885	COG1682	transport, permease protein
IHV08_18890	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IHV08_18890	COG1215	transferase activity, transferring glycosyl groups
IHV08_18895	COG0463	Glycosyl transferase, family 2
IHV08_18940	COG4193	domain, Protein
IHV08_18945	COG1482	cell wall glycoprotein biosynthetic process
IHV08_18950	COG0697	spore germination
IHV08_18955	COG0814	amino acid
IHV08_18965	COG2814	Major facilitator Superfamily
IHV08_18970	COG1316	TRANSCRIPTIONal
IHV08_18975	COG0561	phosphatase activity
IHV08_18980	COG0791	NLP P60 protein
IHV08_18990	COG2843	Capsule synthesis protein
IHV08_19000	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IHV08_19005	COG1609	Transcriptional regulator
IHV08_19010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IHV08_19015	COG1869	D-ribose catabolic process
IHV08_19020	COG1129	ABC transporter
IHV08_19025	COG1172	Belongs to the binding-protein-dependent transport system permease family
IHV08_19030	COG1879	ABC-type sugar transport system periplasmic component
IHV08_19035	COG3103	Sh3 type 3 domain protein
IHV08_19045	COG2249	NAD(P)H dehydrogenase (quinone) activity
IHV08_19050	COG3527	Alpha-acetolactate decarboxylase
IHV08_19055	COG0028	Belongs to the TPP enzyme family
IHV08_19060	COG0583	DNA-binding transcription factor activity
IHV08_19065	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IHV08_19080	COG5337	Spore coat protein CotH
IHV08_19090	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
IHV08_19100	COG0405	Gamma-glutamyltransferase
IHV08_19105	COG1522	sequence-specific DNA binding
IHV08_19110	COG2059	Chromate
IHV08_19115	COG2059	Chromate
IHV08_19125	COG0655	NAD(P)H dehydrogenase (quinone) activity
IHV08_19130	COG0583	DNA-binding transcription factor activity
IHV08_19145	COG5444	nuclease activity
IHV08_19165	COG3878	Protein conserved in bacteria
IHV08_19170	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
IHV08_19175	COG4464	protein tyrosine phosphatase activity
IHV08_19180	COG0489	protein tyrosine kinase activity
IHV08_19185	COG3944	biosynthesis protein
IHV08_19195	COG4715	Zinc finger, swim domain protein
IHV08_19200	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
IHV08_19205	COG0561	phosphatase activity
IHV08_19210	COG1349	DNA-binding transcription factor activity
IHV08_19215	COG0629	single-stranded DNA binding
IHV08_19230	COG3764	Sortase (surface protein transpeptidase)
IHV08_19240	COG3279	Response regulator of the LytR AlgR family
IHV08_19245	COG2972	Histidine kinase
IHV08_19245	COG0745	RESPONSE REGULATOR receiver
IHV08_19250	COG1970	mechanosensitive ion channel activity
IHV08_19255	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IHV08_19260	COG0457	Tetratricopeptide repeat
IHV08_19265	COG4786	Flagellar basal body rod
IHV08_19270	COG4786	Flagellar basal body rod
IHV08_19275	COG1077	Cell shape determining protein MreB Mrl
IHV08_19280	COG1609	Transcriptional regulator
IHV08_19290	COG1846	Transcriptional regulator
IHV08_19295	COG2814	Major facilitator Superfamily
IHV08_19300	COG3420	alginic acid biosynthetic process
IHV08_19305	COG1953	Uracil, thiamine, allantoin
IHV08_19310	COG0477	Major facilitator Superfamily
IHV08_19315	COG1335	isochorismatase
IHV08_19325	COG0004	ammonium transporteR
IHV08_19330	COG0347	Belongs to the P(II) protein family
IHV08_19335	COG0671	phosphoesterase, PA-phosphatase related
IHV08_19345	COG0739	heme binding
IHV08_19350	COG1247	-acetyltransferase
IHV08_19370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IHV08_19375	COG0789	Transcriptional regulator
IHV08_19385	COG2910	NAD(P)H-binding
IHV08_19390	COG1959	2 iron, 2 sulfur cluster binding
IHV08_19395	COG0804	urea catabolic process
IHV08_19400	COG0832	Belongs to the urease beta subunit family
IHV08_19405	COG0831	urea catabolic process
IHV08_19420	COG3237	CsbD-like
IHV08_19425	COG1994	Peptidase M50
IHV08_19430	COG0457	Tetratricopeptide repeat
IHV08_19435	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IHV08_19440	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IHV08_19450	COG2304	oxidoreductase activity
IHV08_19460	COG2304	oxidoreductase activity
IHV08_19465	COG2385	sporulation resulting in formation of a cellular spore
IHV08_19470	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IHV08_19480	COG4836	Membrane
IHV08_19490	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IHV08_19495	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IHV08_19500	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IHV08_19505	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IHV08_19510	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IHV08_19515	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IHV08_19525	COG0356	it plays a direct role in the translocation of protons across the membrane
IHV08_19535	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IHV08_19540	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
IHV08_19545	COG4475	Protein of unknown function (DUF436)
IHV08_19550	COG0698	ribose 5-phosphate isomerase
IHV08_19555	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IHV08_19560	COG1971	Probably functions as a manganese efflux pump
IHV08_19565	COG0009	L-threonylcarbamoyladenylate synthase
IHV08_19570	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
IHV08_19590	COG2890	protein-(glutamine-N5) methyltransferase activity
IHV08_19595	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IHV08_19600	COG0346	lactoylglutathione lyase activity
IHV08_19605	COG0789	Transcriptional regulator
IHV08_19610	COG0679	Auxin Efflux Carrier
IHV08_19615	COG0281	malic enzyme
IHV08_19620	COG1435	thymidine kinase activity
IHV08_19630	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IHV08_19640	COG1494	fructose-1,6-bisphosphatase
IHV08_19645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IHV08_19650	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IHV08_19655	COG0191	fructose-bisphosphate aldolase activity
IHV08_19660	COG2204	response regulator
IHV08_19665	COG4821	SIS domain
IHV08_19670	COG0504	CTP synthase activity
IHV08_19675	COG3343	RNA polymerase activity
IHV08_19680	COG1960	acyl-CoA dehydrogenase activity
IHV08_19685	COG2181	nitrate reductase activity
IHV08_19685	COG0247	lactate metabolic process
IHV08_19690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IHV08_19695	COG4294	response to UV
IHV08_19705	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IHV08_19710	COG1132	(ABC) transporter
IHV08_19715	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
IHV08_19720	COG2181	nitrate reductase activity
IHV08_19725	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
IHV08_19730	COG1140	nitrate reductase beta subunit
IHV08_19735	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
IHV08_19740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IHV08_19750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
IHV08_19755	COG2223	nitrite transmembrane transporter activity
IHV08_19760	COG0018	arginyl-trna synthetase
IHV08_19765	COG4506	Protein conserved in bacteria
IHV08_19780	COG0535	radical SAM domain protein
IHV08_19790	COG1131	(ABC) transporter
IHV08_19795	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
IHV08_19800	COG0612	Peptidase, M16
IHV08_19805	COG0612	Peptidase, M16
IHV08_19815	COG3391	amine dehydrogenase activity
IHV08_19820	COG3391	amine dehydrogenase activity
IHV08_19825	COG0457	Tetratricopeptide repeat
IHV08_19855	COG1131	(ABC) transporter
IHV08_19865	COG0010	Belongs to the arginase family
IHV08_19870	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
IHV08_19875	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
IHV08_19885	COG1994	Peptidase M50
IHV08_19890	COG1942	4-Oxalocrotonate Tautomerase
IHV08_19895	COG1846	Transcriptional regulator
IHV08_19900	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IHV08_19905	COG0477	Major facilitator Superfamily
IHV08_19910	COG1959	2 iron, 2 sulfur cluster binding
IHV08_19915	COG3465	dGTPase activity
IHV08_19920	COG1078	dGTPase activity
IHV08_19925	COG4844	belongs to the
IHV08_19935	COG0697	spore germination
IHV08_19940	COG0095	Lipoate-protein ligase
IHV08_19945	COG0583	DNA-binding transcription factor activity
IHV08_19950	COG0280	phosphate acetyltransferase
IHV08_19955	COG3253	May function as heme-dependent peroxidase
IHV08_19960	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_19965	COG0436	Aminotransferase
IHV08_19970	COG2814	Major facilitator Superfamily
IHV08_19975	COG0151	Belongs to the GarS family
IHV08_19980	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_19985	COG1917	Cupin 2, conserved barrel domain protein
IHV08_19990	COG0077	Prephenate dehydratase
IHV08_19995	COG2814	Major facilitator Superfamily
IHV08_20000	COG0833	amino acid
IHV08_20005	COG4187	Peptidase family M20/M25/M40
IHV08_20010	COG1012	belongs to the aldehyde dehydrogenase family
IHV08_20015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
IHV08_20025	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
IHV08_20030	COG1091	dTDP-4-dehydrorhamnose reductase activity
IHV08_20035	COG1088	dTDP-glucose 4,6-dehydratase activity
IHV08_20040	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
IHV08_20045	COG3980	spore coat polysaccharide biosynthesis protein
IHV08_20050	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
IHV08_20055	COG2089	acid synthase
IHV08_20060	COG0456	acetyltransferase
IHV08_20065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IHV08_20070	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
IHV08_20075	COG0463	Glycosyl transferase, family 2
IHV08_20085	COG2363	Small membrane protein
IHV08_20090	COG2233	PERMEase
IHV08_20100	COG1012	belongs to the aldehyde dehydrogenase family
IHV08_20105	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IHV08_20110	COG1216	Glycosyl transferase, family 2
IHV08_20125	COG1695	Transcriptional regulator
IHV08_20130	COG0351	phosphomethylpyrimidine kinase
IHV08_20140	COG1621	beta-fructofuranosidase activity
IHV08_20145	COG1263	PTS System
IHV08_20145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IHV08_20150	COG2116	formate transmembrane transporter activity
IHV08_20155	COG3711	transcriptional antiterminator
IHV08_20165	COG1404	Belongs to the peptidase S8 family
IHV08_20170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IHV08_20175	COG0778	Nitroreductase
IHV08_20180	COG0772	Belongs to the SEDS family
IHV08_20190	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
IHV08_20195	COG1845	cytochrome c oxidase, subunit III
IHV08_20200	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
IHV08_20205	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
IHV08_20210	COG2261	transglycosylase associated protein
IHV08_20215	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
IHV08_20220	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
IHV08_20225	COG2246	polysaccharide biosynthetic process
IHV08_20230	COG1309	transcriptional regulator
IHV08_20240	COG3162	membrane
IHV08_20245	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IHV08_20250	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IHV08_20255	COG2837	iron assimilation
IHV08_20260	COG2822	iron ion transport
IHV08_20265	COG0672	)-iron permease
IHV08_20270	COG0352	thiamine-phosphate diphosphorylase activity
IHV08_20275	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
IHV08_20280	COG0583	DNA-binding transcription factor activity
IHV08_20285	COG1380	Effector of murein hydrolase LrgA
IHV08_20290	COG1346	cytolysis
IHV08_20295	COG2814	Major facilitator Superfamily
IHV08_20300	COG4895	conserved protein (DUF2196)
IHV08_20305	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
IHV08_20310	COG0346	lactoylglutathione lyase activity
IHV08_20320	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IHV08_20325	COG1404	Belongs to the peptidase S8 family
IHV08_20330	COG1263	PTS System
IHV08_20330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IHV08_20335	COG3711	transcriptional antiterminator
IHV08_20340	COG1442	glycosyl transferase family 8
IHV08_20345	COG5522	Integral membrane protein (intg_mem_TP0381)
IHV08_20350	COG1846	Transcriptional regulator
IHV08_20355	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IHV08_20360	COG2234	aminopeptidase activity
IHV08_20375	COG2814	Major facilitator Superfamily
IHV08_20380	COG2357	RelA SpoT domain protein
IHV08_20385	COG1575	Belongs to the MenA family. Type 1 subfamily
IHV08_20400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
IHV08_20405	COG1696	Membrane protein involved in D-alanine export
IHV08_20410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IHV08_20415	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
IHV08_20420	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
IHV08_20425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
IHV08_20430	COG1486	melibiose metabolic process
IHV08_20435	COG1447	Phosphotransferase system cellobiose-specific component IIA
IHV08_20440	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IHV08_20445	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
IHV08_20450	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
IHV08_20450	COG3711	transcriptional antiterminator
IHV08_20460	COG2094	Belongs to the DNA glycosylase MPG family
IHV08_20465	COG0753	catalase activity
IHV08_20470	COG2814	Major facilitator Superfamily
IHV08_20475	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
IHV08_20480	COG1131	(ABC) transporter
IHV08_20500	COG1595	DNA-templated transcription, initiation
IHV08_20505	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
IHV08_20510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IHV08_20515	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
IHV08_20520	COG4988	ABC transporter
IHV08_20525	COG1294	oxidase, subunit
IHV08_20530	COG1271	oxidase subunit
IHV08_20535	COG3493	citrate carrier protein
IHV08_20540	COG0501	Belongs to the peptidase M48B family
IHV08_20550	COG0726	polysaccharide deacetylase
IHV08_20555	COG3842	ATPase activity
IHV08_20560	COG2508	Transcriptional regulator
IHV08_20565	COG1012	belongs to the aldehyde dehydrogenase family
IHV08_20570	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
IHV08_20580	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IHV08_20590	COG4585	Histidine kinase
IHV08_20595	COG2197	response regulator
IHV08_20600	COG2195	Cleaves the N-terminal amino acid of tripeptides
IHV08_20615	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IHV08_20620	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IHV08_20625	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_20630	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
IHV08_20635	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
IHV08_20640	COG2610	gluconate transmembrane transporter activity
IHV08_20645	COG0500	methyltransferase
IHV08_20650	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IHV08_20665	COG0753	catalase activity
IHV08_20665	COG0693	protein deglycase activity
IHV08_20670	COG2851	Citrate transporter
IHV08_20675	COG2273	Hydrolase Family 16
IHV08_20680	COG3711	transcriptional antiterminator
IHV08_20690	COG2270	Major facilitator Superfamily
IHV08_20695	COG0513	Belongs to the DEAD box helicase family
IHV08_20700	COG2755	lipolytic protein G-D-S-L family
IHV08_20700	COG3401	FG-GAP repeat protein
IHV08_20750	COG3209	COG3209 Rhs family protein
IHV08_20755	COG0697	spore germination
IHV08_20760	COG0589	response to stress
IHV08_20765	COG2723	6-phospho-beta-galactosidase activity
IHV08_20770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
IHV08_20770	COG1263	PTS System
IHV08_20770	COG2190	(PTS) system
IHV08_20805	COG5444	nuclease activity
IHV08_20820	COG3507	Belongs to the glycosyl hydrolase 43 family
IHV08_20830	COG2986	histidine ammonia-lyase
IHV08_20835	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
IHV08_20840	COG1228	amidohydrolase
IHV08_20845	COG0010	Belongs to the arginase family
IHV08_20850	COG0833	amino acid
IHV08_20855	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
IHV08_20860	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
IHV08_20865	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
IHV08_20870	COG2390	Transcriptional regulator
IHV08_20880	COG3192	ethanolamine utilization protein
IHV08_20885	COG2079	MmgE PrpD family protein
IHV08_20890	COG1473	amidohydrolase
IHV08_20895	COG1126	abc transporter atp-binding protein
IHV08_20900	COG0765	amino acid transport
IHV08_20905	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IHV08_20910	COG0456	acetyltransferase
IHV08_20915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
IHV08_20920	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
IHV08_20925	COG0561	phosphatase activity
IHV08_20955	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IHV08_20960	COG5294	Protein conserved in bacteria
IHV08_20965	COG0577	efflux transmembrane transporter activity
IHV08_20970	COG1136	(ABC) transporter
IHV08_20975	COG2205	protein histidine kinase activity
IHV08_20980	COG0745	RESPONSE REGULATOR receiver
IHV08_20985	COG0191	fructose-bisphosphate aldolase activity
IHV08_20990	COG1082	Xylose isomerase domain protein TIM barrel
IHV08_20995	COG1082	Xylose isomerase domain protein TIM barrel
IHV08_21000	COG0673	inositol 2-dehydrogenase activity
IHV08_21005	COG2814	Major facilitator Superfamily
IHV08_21010	COG1082	Xylose isomerase domain protein TIM barrel
IHV08_21015	COG3962	Belongs to the TPP enzyme family
IHV08_21020	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
IHV08_21025	COG3718	enzyme involved in inositol metabolism
IHV08_21030	COG1012	belongs to the aldehyde dehydrogenase family
IHV08_21035	COG1349	DNA-binding transcription factor activity
IHV08_21040	COG0667	Aldo Keto reductase
IHV08_21055	COG2814	Major facilitator Superfamily
IHV08_21060	COG0326	Molecular chaperone. Has ATPase activity
IHV08_21070	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_21075	COG1309	transcriptional regulator
IHV08_21080	COG1012	belongs to the aldehyde dehydrogenase family
IHV08_21090	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IHV08_21100	COG1714	RDD family
IHV08_21105	COG2311	Membrane
IHV08_21110	COG1917	Cupin 2, conserved barrel domain protein
IHV08_21115	COG1309	transcriptional regulator
IHV08_21120	COG1028	Short-chain dehydrogenase reductase Sdr
IHV08_21125	COG1846	Transcriptional regulator
IHV08_21130	COG1380	Effector of murein hydrolase LrgA
IHV08_21135	COG1346	cytolysis
IHV08_21140	COG5039	Polysaccharide pyruvyl transferase
IHV08_21145	COG1929	Belongs to the glycerate kinase type-1 family
IHV08_21150	COG1802	Transcriptional regulator
IHV08_21155	COG1070	Carbohydrate kinase
IHV08_21160	COG2610	gluconate transmembrane transporter activity
IHV08_21165	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
IHV08_21170	COG0450	alkyl hydroperoxide reductase
IHV08_21175	COG3634	alkyl hydroperoxide reductase activity
IHV08_21185	COG2723	6-phospho-beta-galactosidase activity
IHV08_21195	COG2188	Transcriptional regulator
IHV08_21215	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
IHV08_21255	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
IHV08_21270	COG1063	alcohol dehydrogenase
IHV08_21290	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
IHV08_21295	COG0456	acetyltransferase
IHV08_21300	COG0457	Tetratricopeptide repeat
IHV08_21310	COG0010	Belongs to the arginase family
IHV08_21315	COG0833	amino acid
IHV08_21320	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IHV08_21325	COG3829	transcription factor binding
IHV08_21330	COG5002	protein histidine kinase activity
IHV08_21335	COG0745	RESPONSE REGULATOR receiver
IHV08_21355	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IHV08_21360	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
IHV08_21365	COG4853	Protein conserved in bacteria
IHV08_21370	COG4863	YycH protein
IHV08_21375	COG5002	protein histidine kinase activity
IHV08_21380	COG0745	RESPONSE REGULATOR receiver
IHV08_21410	COG0346	lactoylglutathione lyase activity
IHV08_21415	COG0305	Participates in initiation and elongation during chromosome replication
IHV08_21430	COG3093	addiction module antidote protein HigA
IHV08_21435	COG2807	transmembrane transport
IHV08_21440	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
IHV08_21445	COG0359	binds to the 23S rRNA
IHV08_21450	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
IHV08_21455	COG4241	membrane
IHV08_21465	COG5577	PFAM Coat F domain
IHV08_21470	COG1733	regulation of RNA biosynthetic process
IHV08_21475	COG1227	inorganic diphosphatase activity
IHV08_21490	COG2271	Major facilitator Superfamily
IHV08_21495	COG4978	Transcriptional regulator
IHV08_21495	COG0789	Transcriptional regulator
IHV08_21505	COG4319	ketosteroid isomerase
IHV08_21510	COG1357	PFAM Pentapeptide repeats (8 copies)
IHV08_21515	COG2814	Major facilitator Superfamily
IHV08_21520	COG0583	DNA-binding transcription factor activity
IHV08_21525	COG2153	protein acetylation
IHV08_21535	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IHV08_21540	COG1846	Transcriptional regulator
IHV08_21545	COG2153	protein acetylation
IHV08_21550	COG2364	Membrane
IHV08_21555	COG0456	acetyltransferase
IHV08_21560	COG2315	Protein conserved in bacteria
IHV08_21565	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
IHV08_21575	COG2814	Major facilitator Superfamily
IHV08_21585	COG1331	Highly conserved protein containing a thioredoxin domain
IHV08_21590	COG0789	Transcriptional regulator
IHV08_21595	COG0697	spore germination
IHV08_21600	COG1331	Highly conserved protein containing a thioredoxin domain
IHV08_21605	COG1266	CAAX protease self-immunity
IHV08_21610	COG0477	Major facilitator Superfamily
IHV08_21610	COG2814	Major facilitator Superfamily
IHV08_21615	COG0110	maltose O-acetyltransferase activity
IHV08_21620	COG0346	lactoylglutathione lyase activity
IHV08_21625	COG1609	Transcriptional regulator
IHV08_21630	COG0708	Exodeoxyribonuclease III
IHV08_21635	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IHV08_21640	COG0629	single-stranded DNA binding
IHV08_21645	COG0360	Binds together with S18 to 16S ribosomal RNA
IHV08_21650	COG0012	GTP binding
IHV08_21655	COG0243	molybdopterin cofactor binding
IHV08_21660	COG4481	Protein conserved in bacteria
IHV08_21665	COG3949	Membrane
IHV08_21675	COG1475	DNA binding
IHV08_21680	COG1192	Involved in chromosome partitioning
IHV08_21690	COG1475	DNA binding
IHV08_21695	COG0357	Ribosomal RNA small subunit methyltransferase G
IHV08_21700	COG0445	tRNA wobble uridine modification
IHV08_21705	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IHV08_21710	COG1847	R3H domain protein
IHV08_21715	COG0706	membrane insertase activity
IHV08_21720	COG0594	ribonuclease P activity