locus-tag	class	description
K8U58_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K8U58_00010	COG0592	DNA-directed DNA polymerase activity
K8U58_00015	COG2501	S4 domain
K8U58_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
K8U58_00030	COG0187	DNA topoisomerase II activity
K8U58_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K8U58_00070	COG0516	GMP reductase activity
K8U58_00070	COG0517	IMP dehydrogenase activity
K8U58_00075	COG1686	Belongs to the peptidase S11 family
K8U58_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
K8U58_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
K8U58_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K8U58_00100	COG1428	Deoxynucleoside kinase
K8U58_00105	COG1428	Deoxynucleoside kinase
K8U58_00110	COG1388	LysM domain
K8U58_00110	COG3858	chitin binding
K8U58_00115	COG1335	isochorismatase
K8U58_00120	COG0590	tRNA wobble adenosine to inosine editing
K8U58_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K8U58_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
K8U58_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
K8U58_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
K8U58_00190	COG3853	Toxic anion resistance protein (TelA)
K8U58_00195	COG1982	Orn Lys Arg decarboxylase major
K8U58_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K8U58_00205	COG3870	Protein conserved in bacteria
K8U58_00210	COG1728	Protein conserved in bacteria
K8U58_00215	COG0470	DNA polymerase III
K8U58_00220	COG1774	PSP1 C-terminal conserved region
K8U58_00225	COG4467	Involved in initiation control of chromosome replication
K8U58_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K8U58_00235	COG2827	Endonuclease containing a URI domain
K8U58_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
K8U58_00245	COG2002	toxin-antitoxin pair type II binding
K8U58_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K8U58_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K8U58_00255	COG0084	hydrolase, TatD family'
K8U58_00260	COG3584	3D domain protein
K8U58_00260	COG3583	domain protein
K8U58_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K8U58_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K8U58_00280	COG4466	Protein conserved in bacteria
K8U58_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K8U58_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K8U58_00300	COG0251	oxidation-reduction process
K8U58_00305	COG2088	sporulation resulting in formation of a cellular spore
K8U58_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K8U58_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K8U58_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
K8U58_00325	COG0193	aminoacyl-tRNA hydrolase activity
K8U58_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K8U58_00340	COG2002	toxin-antitoxin pair type II binding
K8U58_00345	COG2244	polysaccharide biosynthetic process
K8U58_00350	COG3956	TIGRFAM MazG family protein
K8U58_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
K8U58_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K8U58_00375	COG1098	S1 RNA binding domain
K8U58_00390	COG2208	phosphoserine phosphatase activity
K8U58_00395	COG2304	oxidoreductase activity
K8U58_00400	COG0515	serine threonine protein kinase
K8U58_00405	COG0037	tRNA processing
K8U58_00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K8U58_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K8U58_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K8U58_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K8U58_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K8U58_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K8U58_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K8U58_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
K8U58_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K8U58_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
K8U58_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
K8U58_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K8U58_00470	COG1396	sequence-specific DNA binding
K8U58_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K8U58_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K8U58_00560	COG4463	regulation of RNA biosynthetic process
K8U58_00565	COG3880	PFAM UvrB UvrC protein
K8U58_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
K8U58_00575	COG0542	response to heat
K8U58_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
K8U58_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
K8U58_00590	COG4956	integral membrane protein (PIN domain superfamily)
K8U58_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K8U58_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
K8U58_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K8U58_00610	COG1045	serine acetyltransferase
K8U58_00615	COG0215	cysteine-tRNA ligase activity
K8U58_00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
K8U58_00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K8U58_00630	COG3688	RNA-binding protein containing a PIN domain
K8U58_00635	COG1595	DNA-templated transcription, initiation
K8U58_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K8U58_00650	COG0250	Participates in transcription elongation, termination and antitermination
K8U58_00660	COG0081	regulation of translation
K8U58_00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K8U58_00675	COG2813	Specifically methylates the guanine in position
K8U58_00680	COG0085	RNA polymerase activity
K8U58_00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K8U58_00690	COG1358	cellular component organization or biogenesis
K8U58_00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
K8U58_00700	COG0049	tRNA binding
K8U58_00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
K8U58_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K8U58_00715	COG0596	Alpha beta hydrolase
K8U58_00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
K8U58_00730	COG0088	Forms part of the polypeptide exit tunnel
K8U58_00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
K8U58_00755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
K8U58_00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
K8U58_00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
K8U58_00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
K8U58_00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
K8U58_00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
K8U58_00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
K8U58_00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
K8U58_00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K8U58_00820	COG0200	Binds to the 23S rRNA
K8U58_00825	COG0201	protein transport
K8U58_00830	COG0563	adenylate kinase activity
K8U58_00835	COG0024	Methionine aminopeptidase
K8U58_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
K8U58_00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K8U58_00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
K8U58_00865	COG0202	RNA polymerase activity
K8U58_00870	COG0203	ribosomal protein L17
K8U58_00875	COG1122	ATPase activity
K8U58_00880	COG1122	ATPase activity
K8U58_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K8U58_00890	COG0101	tRNA pseudouridine synthase activity
K8U58_00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K8U58_00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
K8U58_00905	COG2226	methyltransferase
K8U58_00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
K8U58_00920	COG0489	protein tyrosine kinase activity
K8U58_00930	COG2194	sulfuric ester hydrolase activity
K8U58_00935	COG0726	polysaccharide deacetylase
K8U58_01015	COG0659	secondary active sulfate transmembrane transporter activity
K8U58_01020	COG0385	Bile acid
K8U58_01025	COG2819	hydrolase of the alpha beta superfamily
K8U58_01030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K8U58_01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K8U58_01040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K8U58_01045	COG2207	Transcriptional regulator
K8U58_01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K8U58_01050	COG3876	Protein conserved in bacteria
K8U58_01055	COG1472	Belongs to the glycosyl hydrolase 3 family
K8U58_01060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K8U58_01065	COG1263	PTS System
K8U58_01065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K8U58_01070	COG1737	Transcriptional regulator
K8U58_01075	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
K8U58_01080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K8U58_01085	COG1683	Conserved Protein
K8U58_01115	COG1595	DNA-templated transcription, initiation
K8U58_01120	COG5662	AntiSigma factor
K8U58_01125	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
K8U58_01130	COG4856	YbbR-like protein
K8U58_01135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K8U58_01140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K8U58_01150	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K8U58_01155	COG2169	Transcriptional regulator
K8U58_01160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K8U58_01165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K8U58_01170	COG3002	Belongs to the UPF0753 family
K8U58_01175	COG0288	reversible hydration of carbon dioxide
K8U58_01185	COG5609	conserved protein (DUF2294)
K8U58_01190	COG0640	Transcriptional regulator
K8U58_01195	COG2814	Major facilitator Superfamily
K8U58_01210	COG0535	radical SAM domain protein
K8U58_01215	COG1266	CAAX protease self-immunity
K8U58_01220	COG1131	(ABC) transporter
K8U58_01230	COG1413	lyase activity
K8U58_01235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8U58_01240	COG0596	Alpha beta hydrolase
K8U58_01245	COG0745	RESPONSE REGULATOR receiver
K8U58_01250	COG0642	Histidine kinase
K8U58_01260	COG0515	serine threonine protein kinase
K8U58_01275	COG1113	amino acid transport
K8U58_01290	COG2602	Beta-lactamase
K8U58_01295	COG2124	cytochrome p450
K8U58_01305	COG0531	amino acid
K8U58_01310	COG0584	glycerophosphoryl diester phosphodiesterase
K8U58_01315	COG2271	Major facilitator Superfamily
K8U58_01325	COG1846	Transcriptional regulator
K8U58_01325	COG0456	acetyltransferase
K8U58_01330	COG2271	Major facilitator Superfamily
K8U58_01340	COG3409	Peptidoglycan-binding domain 1 protein
K8U58_01345	COG0697	spore germination
K8U58_01350	COG1917	Cupin 2, conserved barrel domain protein
K8U58_01350	COG2207	Transcriptional regulator
K8U58_01355	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
K8U58_01360	COG3591	Belongs to the peptidase S1B family
K8U58_01370	COG0596	Alpha beta hydrolase
K8U58_01375	COG1183	phosphatidylcholine synthase activity
K8U58_01380	COG0586	Pfam SNARE associated Golgi protein
K8U58_01385	COG0688	phosphatidylethanolamine metabolic process
K8U58_01395	COG2312	Erythromycin esterase
K8U58_01400	COG2207	Transcriptional regulator
K8U58_01405	COG1054	Belongs to the UPF0176 family
K8U58_01410	COG1301	dicarboxylic acid transport
K8U58_01415	COG1263	PTS System
K8U58_01415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K8U58_01415	COG2190	(PTS) system
K8U58_01420	COG0363	glucosamine-6-phosphate deaminase activity
K8U58_01425	COG2188	Transcriptional regulator
K8U58_01435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K8U58_01440	COG0833	amino acid
K8U58_01445	COG2040	homocysteine
K8U58_01450	COG1115	amino acid carrier protein
K8U58_01455	COG2066	Belongs to the glutaminase family
K8U58_01460	COG4191	Histidine kinase
K8U58_01465	COG0784	Response regulator, receiver
K8U58_01470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K8U58_01475	COG1012	belongs to the aldehyde dehydrogenase family
K8U58_01480	COG2271	Major facilitator Superfamily
K8U58_01485	COG4948	Mandelate Racemase Muconate Lactonizing
K8U58_01490	COG2186	Transcriptional regulator
K8U58_01495	COG2721	sulfolactate sulfo-lyase activity
K8U58_01500	COG3173	Aminoglycoside phosphotransferase
K8U58_01510	COG0697	spore germination
K8U58_01515	COG0745	RESPONSE REGULATOR receiver
K8U58_01520	COG2205	protein histidine kinase activity
K8U58_01525	COG1131	(ABC) transporter
K8U58_01545	COG3773	Cell wall hydrolase
K8U58_01550	COG2304	oxidoreductase activity
K8U58_01560	COG3540	Alkaline phosphatase
K8U58_01565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K8U58_01570	COG0805	protein transport
K8U58_01575	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
K8U58_01580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K8U58_01585	COG0477	Major facilitator Superfamily
K8U58_01590	COG1309	transcriptional regulator
K8U58_01595	COG0252	asparaginase activity
K8U58_01600	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K8U58_01605	COG1714	RDD family
K8U58_01610	COG1405	negative regulation of cell septum assembly
K8U58_01610	COG3012	SEC-C Motif Domain Protein
K8U58_01615	COG3290	protein histidine kinase activity
K8U58_01620	COG3279	Response regulator of the LytR AlgR family
K8U58_01625	COG4555	ABC transporter
K8U58_01630	COG1668	transmembrane transport
K8U58_01635	COG0667	Aldo Keto reductase
K8U58_01650	COG1595	DNA-templated transcription, initiation
K8U58_01655	COG1595	DNA-templated transcription, initiation
K8U58_01660	COG1876	peptidase activity
K8U58_01665	COG0457	Tetratricopeptide repeat
K8U58_01670	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_01675	COG0366	Alpha amylase catalytic
K8U58_01680	COG0803	Belongs to the bacterial solute-binding protein 9 family
K8U58_01685	COG1121	(ABC) transporter
K8U58_01690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K8U58_01695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K8U58_01705	COG2310	stress, protein
K8U58_01710	COG2310	stress, protein
K8U58_01715	COG0861	Integral membrane protein TerC family
K8U58_01725	COG3853	Toxic anion resistance protein (TelA)
K8U58_01730	COG0477	Major facilitator Superfamily
K8U58_01735	COG2814	Major facilitator Superfamily
K8U58_01740	COG0640	Transcriptional regulator
K8U58_01745	COG0517	IMP dehydrogenase activity
K8U58_01745	COG4175	Glycine betaine
K8U58_01750	COG4176	ABC-type proline glycine betaine transport system permease component
K8U58_01755	COG2113	Glycine betaine
K8U58_01760	COG1473	amidohydrolase
K8U58_01765	COG1288	antiporter activity
K8U58_01775	COG0366	Alpha amylase catalytic
K8U58_01780	COG0039	L-malate dehydrogenase activity
K8U58_01785	COG1620	l-lactate permease
K8U58_01790	COG2814	Major facilitator Superfamily
K8U58_01795	COG1846	Transcriptional regulator
K8U58_01800	COG1280	lysine exporter protein (LysE YggA)
K8U58_01805	COG3403	YqcI/YcgG family
K8U58_01810	COG1113	amino acid transport
K8U58_01815	COG3665	Urea carboxylase-associated protein
K8U58_01820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K8U58_01825	COG1660	Displays ATPase and GTPase activities
K8U58_01830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
K8U58_01835	COG2226	methyltransferase
K8U58_01840	COG0583	DNA-binding transcription factor activity
K8U58_01845	COG3458	cephalosporin-C deacetylase activity
K8U58_01850	COG3541	Predicted nucleotidyltransferase
K8U58_01855	COG0506	proline dehydrogenase activity
K8U58_01860	COG1012	belongs to the aldehyde dehydrogenase family
K8U58_01865	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K8U58_01870	COG2508	Transcriptional regulator
K8U58_01875	COG3689	TIGRFAM TIGR03943 family protein
K8U58_01880	COG0701	Predicted permease
K8U58_01885	COG2267	carboxylic ester hydrolase activity
K8U58_01890	COG0492	ferredoxin-NADP+ reductase activity
K8U58_01895	COG1587	Uroporphyrinogen-III synthase
K8U58_01895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K8U58_01900	COG2146	nitrite reductase [NAD(P)H] activity
K8U58_01905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K8U58_01910	COG0243	molybdopterin cofactor binding
K8U58_01915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K8U58_01920	COG2223	nitrite transmembrane transporter activity
K8U58_01925	COG1469	GTP cyclohydrolase I activity
K8U58_01930	COG1376	ErfK ybiS ycfS ynhG family protein
K8U58_01940	COG0523	cobalamin synthesis protein
K8U58_01945	COG0765	amino acid transport
K8U58_01950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K8U58_01960	COG1714	RDD family
K8U58_01970	COG2723	6-phospho-beta-galactosidase activity
K8U58_01980	COG3209	COG3209 Rhs family protein
K8U58_01985	COG0840	transmembrane signaling receptor activity
K8U58_01985	COG3290	protein histidine kinase activity
K8U58_01990	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
K8U58_01995	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
K8U58_02000	COG1733	regulation of RNA biosynthetic process
K8U58_02005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K8U58_02010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K8U58_02015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K8U58_02020	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
K8U58_02025	COG2814	Major facilitator Superfamily
K8U58_02035	COG0697	spore germination
K8U58_02040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K8U58_02050	COG2364	Membrane
K8U58_02055	COG1126	abc transporter atp-binding protein
K8U58_02060	COG0765	amino acid transport
K8U58_02065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K8U58_02070	COG0583	DNA-binding transcription factor activity
K8U58_02075	COG0163	prenyltransferase activity
K8U58_02080	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K8U58_02095	COG0596	Alpha beta hydrolase
K8U58_02100	COG3104	oligopeptide transport
K8U58_02105	COG5434	Belongs to the glycosyl hydrolase 28 family
K8U58_02115	COG0697	spore germination
K8U58_02125	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K8U58_02130	COG1136	(ABC) transporter
K8U58_02135	COG0577	efflux transmembrane transporter activity
K8U58_02140	COG0745	RESPONSE REGULATOR receiver
K8U58_02145	COG3850	Histidine kinase
K8U58_02145	COG5002	protein histidine kinase activity
K8U58_02150	COG0457	Tetratricopeptide repeat
K8U58_02170	COG0527	aspartate kinase activity
K8U58_02175	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K8U58_02180	COG4605	iron ion homeostasis
K8U58_02185	COG4604	ABC transporter, ATP-binding protein
K8U58_02190	COG4607	ABC-type enterochelin transport system periplasmic component
K8U58_02195	COG2814	Major facilitator Superfamily
K8U58_02200	COG1309	transcriptional regulator
K8U58_02205	COG0778	Nitroreductase
K8U58_02210	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K8U58_02215	COG0640	Transcriptional regulator
K8U58_02220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K8U58_02225	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K8U58_02230	COG1012	belongs to the aldehyde dehydrogenase family
K8U58_02235	COG4975	Glucose uptake
K8U58_02240	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_02245	COG4549	nuclear export factor GLE1
K8U58_02250	COG1276	copper resistance
K8U58_02250	COG2372	response to copper ion
K8U58_02255	COG1349	DNA-binding transcription factor activity
K8U58_02265	COG2213	PTS system mannitol-specific
K8U58_02270	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8U58_02275	COG0246	Mannitol dehydrogenase
K8U58_02280	COG0473	3-isopropylmalate dehydrogenase activity
K8U58_02285	COG0681	Belongs to the peptidase S26 family
K8U58_02290	COG0412	Dienelactone hydrolase
K8U58_02295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K8U58_02305	COG0561	phosphatase activity
K8U58_02310	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K8U58_02315	COG1914	H( )-stimulated, divalent metal cation uptake system
K8U58_02320	COG4336	lyase activity
K8U58_02325	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K8U58_02330	COG1984	allophanate hydrolase subunit 2
K8U58_02335	COG1414	Transcriptional regulator
K8U58_02340	COG2755	lipolytic protein G-D-S-L family
K8U58_02350	COG2329	Antibiotic biosynthesis monooxygenase
K8U58_02355	COG0768	penicillin binding
K8U58_02360	COG4989	oxidoreductase activity
K8U58_02365	COG3711	transcriptional antiterminator
K8U58_02370	COG0318	PFAM AMP-dependent synthetase and ligase
K8U58_02375	COG2226	methyltransferase
K8U58_02380	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_02385	COG1917	Cupin 2, conserved barrel domain protein
K8U58_02390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K8U58_02395	COG3871	stress protein (general stress protein 26)
K8U58_02405	COG2814	Major facilitator Superfamily
K8U58_02410	COG1522	sequence-specific DNA binding
K8U58_02415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K8U58_02415	COG0551	DNA topoisomerase type I activity
K8U58_02420	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K8U58_02425	COG3706	GGDEF domain
K8U58_02430	COG5298	Protein conserved in bacteria
K8U58_02435	COG1215	transferase activity, transferring glycosyl groups
K8U58_02445	COG0531	amino acid
K8U58_02450	COG0494	nUDIX hydrolase
K8U58_02455	COG0028	Belongs to the TPP enzyme family
K8U58_02470	COG1914	H( )-stimulated, divalent metal cation uptake system
K8U58_02475	COG2261	transglycosylase associated protein
K8U58_02480	COG4876	unkown
K8U58_02485	COG2217	Heavy metal translocating P-type atpase
K8U58_02490	COG3729	General stress protein
K8U58_02495	COG0662	Cupin 2, conserved barrel domain protein
K8U58_02500	COG2329	Antibiotic biosynthesis monooxygenase
K8U58_02505	COG3546	catalase activity
K8U58_02510	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K8U58_02515	COG3290	protein histidine kinase activity
K8U58_02520	COG4565	transcriptional regulatory protein
K8U58_02525	COG1301	dicarboxylic acid transport
K8U58_02530	COG0628	permease
K8U58_02535	COG1131	(ABC) transporter
K8U58_02540	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K8U58_02550	COG1960	acyl-CoA dehydrogenase activity
K8U58_02565	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K8U58_02570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8U58_02575	COG1181	Belongs to the D-alanine--D-alanine ligase family
K8U58_02580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K8U58_02585	COG0513	Belongs to the DEAD box helicase family
K8U58_02590	COG3402	PFAM membrane-flanked domain
K8U58_02595	COG3428	Bacterial PH domain
K8U58_02600	COG0705	Rhomboid family
K8U58_02605	COG0736	holo-[acyl-carrier-protein] synthase activity
K8U58_02610	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K8U58_02615	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K8U58_02620	COG0864	Transcriptional regulator
K8U58_02625	COG2337	Toxic component of a toxin-antitoxin (TA) module
K8U58_02630	COG1366	Belongs to the anti-sigma-factor antagonist family
K8U58_02635	COG1366	Belongs to the anti-sigma-factor antagonist family
K8U58_02640	COG2172	sigma factor antagonist activity
K8U58_02645	COG2208	phosphoserine phosphatase activity
K8U58_02650	COG1366	Belongs to the anti-sigma-factor antagonist family
K8U58_02655	COG2172	sigma factor antagonist activity
K8U58_02660	COG1191	sigma factor activity
K8U58_02665	COG2208	phosphoserine phosphatase activity
K8U58_02680	COG1673	EVE domain
K8U58_02685	COG1846	Transcriptional regulator
K8U58_02690	COG2183	response to ionizing radiation
K8U58_02700	COG3091	SprT-like family
K8U58_02740	COG0582	viral genome integration into host DNA
K8U58_02745	COG2856	Zn peptidase
K8U58_02750	COG1396	sequence-specific DNA binding
K8U58_02780	COG1674	ftsk spoiiie
K8U58_02785	COG2946	Replication initiation factor
K8U58_02820	COG0433	COG0433 Predicted ATPase
K8U58_02830	COG5644	endopeptidase inhibitor activity
K8U58_02835	COG0741	lytic transglycosylase activity
K8U58_02835	COG0791	NLP P60 protein
K8U58_02855	COG0457	Tetratricopeptide repeat
K8U58_02870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K8U58_02875	COG1522	sequence-specific DNA binding
K8U58_02880	COG1522	sequence-specific DNA binding
K8U58_02885	COG1335	isochorismatase
K8U58_02890	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K8U58_02895	COG2814	Major facilitator Superfamily
K8U58_02915	COG0693	protein deglycase activity
K8U58_02920	COG1278	Cold shock
K8U58_02925	COG1329	Transcriptional regulator
K8U58_02935	COG1917	Cupin 2, conserved barrel domain protein
K8U58_02935	COG2207	Transcriptional regulator
K8U58_02940	COG0697	spore germination
K8U58_02945	COG2207	Transcriptional regulator
K8U58_02945	COG3708	Transcriptional regulator
K8U58_02950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K8U58_02955	COG0477	Major facilitator Superfamily
K8U58_02965	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
K8U58_02975	COG0697	spore germination
K8U58_02980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K8U58_02985	COG2030	dehydratase
K8U58_02990	COG3545	Serine hydrolase
K8U58_02995	COG1733	regulation of RNA biosynthetic process
K8U58_03000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K8U58_03005	COG1733	regulation of RNA biosynthetic process
K8U58_03010	COG2249	NAD(P)H dehydrogenase (quinone) activity
K8U58_03015	COG2814	Major facilitator Superfamily
K8U58_03020	COG1309	transcriptional regulator
K8U58_03025	COG0640	Transcriptional regulator
K8U58_03030	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K8U58_03040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K8U58_03045	COG0697	spore germination
K8U58_03050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K8U58_03055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K8U58_03060	COG0640	Transcriptional regulator
K8U58_03065	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K8U58_03080	COG4585	Histidine kinase
K8U58_03085	COG2197	response regulator
K8U58_03090	COG2409	Drug exporters of the RND superfamily
K8U58_03095	COG0596	Alpha beta hydrolase
K8U58_03100	COG1811	Na channel or pump
K8U58_03105	COG0789	Transcriptional regulator
K8U58_03105	COG4978	Transcriptional regulator
K8U58_03110	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K8U58_03115	COG0778	Nitroreductase
K8U58_03120	COG0346	lactoylglutathione lyase activity
K8U58_03125	COG2259	Doxx family
K8U58_03130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8U58_03145	COG2323	membrane
K8U58_03150	COG2323	membrane
K8U58_03155	COG0071	Belongs to the small heat shock protein (HSP20) family
K8U58_03170	COG1309	transcriptional regulator
K8U58_03180	COG0456	acetyltransferase
K8U58_03185	COG0488	(ABC) transporter
K8U58_03190	COG1113	amino acid transport
K8U58_03195	COG2318	DinB family
K8U58_03200	COG1846	Transcriptional regulator
K8U58_03205	COG1033	growth of symbiont in host cell
K8U58_03205	COG2409	Drug exporters of the RND superfamily
K8U58_03210	COG0778	Nitroreductase
K8U58_03215	COG1846	Transcriptional regulator
K8U58_03220	COG2814	Major facilitator Superfamily
K8U58_03225	COG0730	response to heat
K8U58_03230	COG1802	Transcriptional regulator
K8U58_03235	COG1388	LysM domain
K8U58_03235	COG3858	chitin binding
K8U58_03240	COG1819	glycosyl
K8U58_03250	COG1785	Belongs to the alkaline phosphatase family
K8U58_03255	COG5646	InterPro IPR014922
K8U58_03265	COG0454	-acetyltransferase
K8U58_03270	COG1078	dGTPase activity
K8U58_03275	COG1388	LysM domain
K8U58_03280	COG2814	Major facilitator Superfamily
K8U58_03285	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K8U58_03290	COG1447	Phosphotransferase system cellobiose-specific component IIA
K8U58_03295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K8U58_03300	COG2723	6-phospho-beta-galactosidase activity
K8U58_03305	COG2188	Transcriptional regulator
K8U58_03310	COG1940	carbohydrate kinase activity
K8U58_03315	COG1482	cell wall glycoprotein biosynthetic process
K8U58_03320	COG4124	Belongs to the glycosyl hydrolase 26 family
K8U58_03365	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
K8U58_03370	COG0802	atpase or kinase
K8U58_03375	COG1214	PFAM Peptidase M22, glycoprotease
K8U58_03380	COG0456	acetyltransferase
K8U58_03385	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K8U58_03390	COG0488	(ABC) transporter
K8U58_03395	COG0315	cyclic pyranopterin monophosphate synthase activity
K8U58_03400	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
K8U58_03405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K8U58_03410	COG0805	protein transport
K8U58_03420	COG1266	CAAX protease self-immunity
K8U58_03430	COG0459	protein refolding
K8U58_03440	COG3378	Phage plasmid primase P4 family
K8U58_03455	COG0270	DNA (cytosine-5-)-methyltransferase activity
K8U58_03460	COG0270	DNA (cytosine-5-)-methyltransferase activity
K8U58_03480	COG1401	restriction endodeoxyribonuclease activity
K8U58_03500	COG0457	Tetratricopeptide repeat
K8U58_03505	COG1063	alcohol dehydrogenase
K8U58_03510	COG2211	Major facilitator Superfamily
K8U58_03515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K8U58_03520	COG1842	Phage shock protein A
K8U58_03525	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K8U58_03530	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
K8U58_03535	COG4260	virion core protein, lumpy skin disease virus
K8U58_03545	COG2814	Major facilitator Superfamily
K8U58_03550	COG1063	alcohol dehydrogenase
K8U58_03555	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
K8U58_03560	COG0823	Involved in the tonB-independent uptake of proteins
K8U58_03575	COG2267	carboxylic ester hydrolase activity
K8U58_03585	COG2132	Multicopper oxidase
K8U58_03590	COG1113	amino acid transport
K8U58_03600	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
K8U58_03605	COG0714	Associated with various cellular activities
K8U58_03610	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
K8U58_03615	COG1305	Transglutaminase-like
K8U58_03620	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K8U58_03620	COG0519	Catalyzes the synthesis of GMP from XMP
K8U58_03625	COG2252	PERMEase
K8U58_03630	COG3064	Membrane
K8U58_03640	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
K8U58_03650	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K8U58_03655	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K8U58_03660	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
K8U58_03665	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K8U58_03670	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K8U58_03675	COG0047	phosphoribosylformylglycinamidine synthase activity
K8U58_03680	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K8U58_03685	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
K8U58_03690	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K8U58_03695	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K8U58_03700	COG0138	bifunctional purine biosynthesis protein purh
K8U58_03705	COG0151	Belongs to the GarS family
K8U58_03710	COG1522	sequence-specific DNA binding
K8U58_03715	COG0531	amino acid
K8U58_03725	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K8U58_03730	COG1470	cell adhesion involved in biofilm formation
K8U58_03735	COG4496	protein, YerC YecD
K8U58_03740	COG0069	glutamate synthase activity
K8U58_03745	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
K8U58_03750	COG0210	DNA helicase
K8U58_03755	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K8U58_03760	COG4851	CamS sex pheromone cAM373 precursor
K8U58_03765	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K8U58_03770	COG1285	pathogenesis
K8U58_03775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K8U58_03780	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K8U58_03785	COG0154	amidase activity
K8U58_03790	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K8U58_03795	COG1309	transcriptional regulator
K8U58_03800	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K8U58_03805	COG1597	lipid kinase activity
K8U58_03810	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K8U58_03815	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K8U58_03820	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K8U58_03825	COG1002	Type II restriction enzyme, methylase subunits
K8U58_03830	COG1061	Type III restriction enzyme res subunit
K8U58_03835	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K8U58_03855	COG5444	nuclease activity
K8U58_03860	COG3391	amine dehydrogenase activity
K8U58_03865	COG0457	Tetratricopeptide repeat
K8U58_03875	COG0217	transcriptional regulatory protein
K8U58_03885	COG1309	transcriptional regulator
K8U58_03890	COG3631	Ketosteroid isomerase-related protein
K8U58_03895	COG0702	epimerase
K8U58_03910	COG3546	catalase activity
K8U58_03915	COG0454	-acetyltransferase
K8U58_03925	COG5578	integral membrane protein
K8U58_03930	COG2972	Histidine kinase
K8U58_03935	COG2207	Transcriptional regulator
K8U58_03935	COG4753	response regulator
K8U58_03940	COG1653	transport
K8U58_03945	COG1175	transmembrane transport
K8U58_03950	COG0395	ABC-type sugar transport system, permease component
K8U58_03955	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K8U58_03960	COG2207	Transcriptional regulator
K8U58_03965	COG2755	lipolytic protein G-D-S-L family
K8U58_03975	COG5578	integral membrane protein
K8U58_03980	COG3401	FG-GAP repeat protein
K8U58_03985	COG3401	FG-GAP repeat protein
K8U58_03990	COG2755	lipolytic protein G-D-S-L family
K8U58_03995	COG1874	Beta-galactosidase
K8U58_04005	COG1653	transport
K8U58_04010	COG4209	transmembrane transport
K8U58_04015	COG0395	ABC-type sugar transport system, permease component
K8U58_04020	COG1486	melibiose metabolic process
K8U58_04025	COG2323	membrane
K8U58_04030	COG2329	Antibiotic biosynthesis monooxygenase
K8U58_04035	COG0346	lactoylglutathione lyase activity
K8U58_04050	COG5583	Uncharacterized small protein (DUF2292)
K8U58_04055	COG0670	Belongs to the BI1 family
K8U58_04060	COG0697	spore germination
K8U58_04065	COG1846	Transcriptional regulator
K8U58_04070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K8U58_04080	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K8U58_04080	COG2124	cytochrome p450
K8U58_04085	COG1368	sulfuric ester hydrolase activity
K8U58_04090	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
K8U58_04095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K8U58_04100	COG1442	glycosyl transferase family 8
K8U58_04105	COG1216	Glycosyl transferase, family 2
K8U58_04110	COG1442	glycosyl transferase family 8
K8U58_04115	COG2223	nitrite transmembrane transporter activity
K8U58_04120	COG1011	Hydrolase
K8U58_04125	COG0531	amino acid
K8U58_04130	COG1012	belongs to the aldehyde dehydrogenase family
K8U58_04135	COG0840	transmembrane signaling receptor activity
K8U58_04140	COG0488	(ABC) transporter
K8U58_04150	COG0789	Transcriptional regulator
K8U58_04155	COG2814	Major facilitator Superfamily
K8U58_04165	COG0488	(ABC) transporter
K8U58_04170	COG0513	Belongs to the DEAD box helicase family
K8U58_04175	COG0456	acetyltransferase
K8U58_04180	COG2130	NADP-dependent
K8U58_04185	COG2211	Major facilitator Superfamily
K8U58_04190	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K8U58_04195	COG1120	ATPase activity
K8U58_04200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K8U58_04205	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K8U58_04210	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K8U58_04225	COG3866	Pectate lyase
K8U58_04230	COG0471	metal ion transport
K8U58_04235	COG3290	protein histidine kinase activity
K8U58_04240	COG4565	transcriptional regulatory protein
K8U58_04245	COG3181	Tripartite tricarboxylate transporter family receptor
K8U58_04250	COG2851	Citrate transporter
K8U58_04255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8U58_04260	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
K8U58_04265	COG1254	Belongs to the acylphosphatase family
K8U58_04270	COG2258	MOSC domain
K8U58_04290	COG0024	Methionine aminopeptidase
K8U58_04295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K8U58_04295	COG1263	PTS System
K8U58_04300	COG1368	sulfuric ester hydrolase activity
K8U58_04315	COG1115	amino acid carrier protein
K8U58_04320	COG0531	amino acid
K8U58_04335	COG0697	spore germination
K8U58_04340	COG1263	PTS System
K8U58_04340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K8U58_04345	COG0366	Alpha amylase catalytic
K8U58_04350	COG2188	Transcriptional regulator
K8U58_04355	COG0778	Nitroreductase
K8U58_04360	COG0737	Belongs to the 5'-nucleotidase family
K8U58_04365	COG0693	protein deglycase activity
K8U58_04370	COG2814	Major facilitator Superfamily
K8U58_04375	COG4840	Belongs to the UPF0435 family
K8U58_04380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K8U58_04385	COG4980	gas vesicle protein
K8U58_04390	COG1295	ribonuclease BN
K8U58_04395	COG0477	Major facilitator Superfamily
K8U58_04400	COG0387	Pfam Sodium calcium exchanger
K8U58_04410	COG0668	transmembrane transport
K8U58_04415	COG0535	radical SAM domain protein
K8U58_04425	COG0726	polysaccharide deacetylase
K8U58_04430	COG2084	Dehydrogenase
K8U58_04435	COG0598	Magnesium transport protein CorA
K8U58_04440	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
K8U58_04445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
K8U58_04455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K8U58_04460	COG4637	Psort location Cytoplasmic, score
K8U58_04470	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K8U58_04475	COG0022	dehydrogenase e1 component
K8U58_04480	COG0508	dehydrogenase complex catalyzes the overall conversion of
K8U58_04485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K8U58_04490	COG3284	Transcriptional regulator
K8U58_04500	COG1742	UPF0060 membrane protein
K8U58_04525	COG4842	Belongs to the WXG100 family
K8U58_04530	COG1486	melibiose metabolic process
K8U58_04535	COG1737	Transcriptional regulator
K8U58_04540	COG1263	PTS System
K8U58_04540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K8U58_04545	COG1132	(ABC) transporter
K8U58_04550	COG1132	(ABC) transporter
K8U58_04555	COG2259	Doxx family
K8U58_04560	COG2514	catechol 2,3-dioxygenase activity
K8U58_04565	COG1917	Cupin 2, conserved barrel domain protein
K8U58_04565	COG4977	sequence-specific DNA binding
K8U58_04570	COG2814	Major facilitator Superfamily
K8U58_04575	COG1082	Xylose isomerase domain protein TIM barrel
K8U58_04580	COG0673	inositol 2-dehydrogenase activity
K8U58_04585	COG4585	Histidine kinase
K8U58_04590	COG2197	response regulator
K8U58_04595	COG1131	(ABC) transporter
K8U58_04600	COG1511	domain protein
K8U58_04600	COG0842	Transport permease protein
K8U58_04605	COG0842	Transport permease protein
K8U58_04610	COG1695	Transcriptional regulator
K8U58_04615	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K8U58_04620	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
K8U58_04625	COG1309	transcriptional regulator
K8U58_04630	COG2814	Major facilitator Superfamily
K8U58_04635	COG2318	DinB family
K8U58_04640	COG2814	Major facilitator Superfamily
K8U58_04645	COG1846	Transcriptional regulator
K8U58_04650	COG0392	lysyltransferase activity
K8U58_04650	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K8U58_04655	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K8U58_04660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K8U58_04665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K8U58_04670	COG0384	phenazine biosynthesis protein PhzF
K8U58_04675	COG0778	Nitroreductase
K8U58_04690	COG1090	epimerase
K8U58_04695	COG2137	regulation of response to DNA damage stimulus
K8U58_04705	COG2814	Major facilitator Superfamily
K8U58_04720	COG3103	Sh3 type 3 domain protein
K8U58_04725	COG5658	integral membrane protein
K8U58_04730	COG0596	Alpha beta hydrolase
K8U58_04735	COG0463	Glycosyl transferase, family 2
K8U58_04740	COG4485	Bacterial membrane protein, YfhO
K8U58_04745	COG1988	membrane-bound metal-dependent
K8U58_04750	COG1194	a g-specific adenine glycosylase
K8U58_04760	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_04775	COG3557	Belongs to the UPF0374 family
K8U58_04780	COG1132	(ABC) transporter
K8U58_04785	COG4129	membrane
K8U58_04790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K8U58_04795	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K8U58_04800	COG0735	belongs to the Fur family
K8U58_04910	COG4326	sporulation control protein
K8U58_04920	COG5577	PFAM Coat F domain
K8U58_04925	COG3340	Belongs to the peptidase S51 family
K8U58_04930	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K8U58_04935	COG0277	FAD linked oxidase domain protein
K8U58_04945	COG0753	catalase activity
K8U58_04950	COG1116	anion transmembrane transporter activity
K8U58_04955	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K8U58_04960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K8U58_04965	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K8U58_04975	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
K8U58_04985	COG1476	TRANSCRIPTIONal
K8U58_04995	COG3382	B3 4 domain protein
K8U58_05000	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K8U58_05010	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
K8U58_05015	COG0789	Transcriptional regulator
K8U58_05020	COG1664	Polymer-forming cytoskeletal
K8U58_05025	COG1664	Polymer-forming cytoskeletal
K8U58_05030	COG2766	serine protein kinase
K8U58_05035	COG2718	Belongs to the UPF0229 family
K8U58_05040	COG1846	Transcriptional regulator
K8U58_05045	COG1566	PFAM secretion protein HlyD family protein
K8U58_05050	COG2814	Major facilitator Superfamily
K8U58_05055	COG0655	NAD(P)H dehydrogenase (quinone) activity
K8U58_05075	COG1725	Transcriptional regulator
K8U58_05080	COG1131	(ABC) transporter
K8U58_05085	COG1131	(ABC) transporter
K8U58_05090	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K8U58_05095	COG1278	Cold shock
K8U58_05100	COG1464	Belongs to the NlpA lipoprotein family
K8U58_05105	COG3706	GGDEF domain
K8U58_05110	COG1823	symporter activity
K8U58_05130	COG5577	PFAM Coat F domain
K8U58_05135	COG4085	toxin activity
K8U58_05135	COG0737	Belongs to the 5'-nucleotidase family
K8U58_05135	COG1525	nuclease
K8U58_05140	COG3764	Sortase (surface protein transpeptidase)
K8U58_05145	COG0564	pseudouridine synthase activity
K8U58_05155	COG0517	IMP dehydrogenase activity
K8U58_05160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K8U58_05165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K8U58_05165	COG3153	acetyltransferase
K8U58_05170	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K8U58_05175	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
K8U58_05180	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K8U58_05185	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K8U58_05190	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K8U58_05195	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K8U58_05200	COG2203	Gaf domain
K8U58_05200	COG4585	Histidine kinase
K8U58_05205	COG2197	response regulator
K8U58_05210	COG0431	NADPH-dependent FMN reductase
K8U58_05225	COG0791	NLP P60 protein
K8U58_05225	COG1388	LysM domain
K8U58_05230	COG1959	2 iron, 2 sulfur cluster binding
K8U58_05235	COG0668	transmembrane transport
K8U58_05240	COG2719	SpoVR family
K8U58_05245	COG1785	Belongs to the alkaline phosphatase family
K8U58_05250	COG1388	LysM domain
K8U58_05250	COG0791	NLP P60 protein
K8U58_05255	COG0583	DNA-binding transcription factor activity
K8U58_05260	COG0372	Belongs to the citrate synthase family
K8U58_05265	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_05270	COG0531	amino acid
K8U58_05275	COG0733	neurotransmitter:sodium symporter activity
K8U58_05280	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K8U58_05285	COG0456	acetyltransferase
K8U58_05300	COG1595	DNA-templated transcription, initiation
K8U58_05305	COG0667	Aldo Keto reductase
K8U58_05310	COG0204	Acyl-transferase
K8U58_05315	COG1253	flavin adenine dinucleotide binding
K8U58_05320	COG0789	Transcriptional regulator
K8U58_05325	COG0436	Aminotransferase
K8U58_05330	COG1253	flavin adenine dinucleotide binding
K8U58_05335	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K8U58_05340	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K8U58_05345	COG0584	glycerophosphoryl diester phosphodiesterase
K8U58_05355	COG0668	transmembrane transport
K8U58_05360	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K8U58_05365	COG0726	polysaccharide deacetylase
K8U58_05370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K8U58_05375	COG1757	Na H antiporter
K8U58_05380	COG0589	response to stress
K8U58_05390	COG1132	(ABC) transporter
K8U58_05395	COG1132	(ABC) transporter
K8U58_05400	COG0702	epimerase
K8U58_05420	COG0189	ligase activity
K8U58_05425	COG0189	ligase activity
K8U58_05430	COG4399	Belongs to the UPF0754 family
K8U58_05435	COG3679	Belongs to the UPF0342 family
K8U58_05440	COG4335	DNA alkylation repair
K8U58_05445	COG0561	phosphatase activity
K8U58_05450	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K8U58_05455	COG0475	glutathione-regulated potassium exporter activity
K8U58_05460	COG0490	domain, Protein
K8U58_05470	COG1024	Enoyl-CoA hydratase
K8U58_05480	COG4152	abc transporter atp-binding protein
K8U58_05485	COG1668	transmembrane transport
K8U58_05490	COG0420	3'-5' exonuclease activity
K8U58_05495	COG4717	serine-type aminopeptidase activity
K8U58_05500	COG3481	metal-dependent phosphohydrolase, HD sub domain
K8U58_05510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K8U58_05540	COG1846	Transcriptional regulator
K8U58_05545	COG4980	gas vesicle protein
K8U58_05560	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K8U58_05565	COG0537	adenosine 5'-monophosphoramidase activity
K8U58_05570	COG1131	(ABC) transporter
K8U58_05575	COG4473	ABC transporter
K8U58_05585	COG1473	amidohydrolase
K8U58_05590	COG3069	C4-dicarboxylate transmembrane transporter activity
K8U58_05600	COG2329	Antibiotic biosynthesis monooxygenase
K8U58_05605	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K8U58_05610	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K8U58_05615	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
K8U58_05620	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K8U58_05625	COG1309	transcriptional regulator
K8U58_05630	COG1511	domain protein
K8U58_05635	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K8U58_05640	COG4377	Putative membrane peptidase family (DUF2324)
K8U58_05650	COG1363	Peptidase, m42
K8U58_05655	COG4405	Protein conserved in bacteria
K8U58_05660	COG1301	dicarboxylic acid transport
K8U58_05670	COG1234	tRNA 3'-trailer cleavage
K8U58_05675	COG0095	Lipoate-protein ligase
K8U58_05680	COG0702	epimerase
K8U58_05685	COG0318	PFAM AMP-dependent synthetase and ligase
K8U58_05695	COG0501	Belongs to the peptidase M48B family
K8U58_05700	COG1404	Belongs to the peptidase S8 family
K8U58_05705	COG0456	acetyltransferase
K8U58_05710	COG0604	alcohol dehydrogenase
K8U58_05715	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
K8U58_05720	COG0406	alpha-ribazole phosphatase activity
K8U58_05725	COG0183	Belongs to the thiolase family
K8U58_05730	COG0318	PFAM AMP-dependent synthetase and ligase
K8U58_05735	COG1268	BioY protein
K8U58_05740	COG0840	transmembrane signaling receptor activity
K8U58_05745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K8U58_05745	COG0723	plastoquinol--plastocyanin reductase activity
K8U58_05750	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_05760	COG4903	ComK protein
K8U58_05765	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_05775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K8U58_05790	COG0398	Pfam SNARE associated Golgi protein
K8U58_05795	COG0681	Belongs to the peptidase S26 family
K8U58_05800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K8U58_05805	COG1846	Transcriptional regulator
K8U58_05810	COG0738	Major facilitator superfamily
K8U58_05815	COG0673	inositol 2-dehydrogenase activity
K8U58_05820	COG0561	phosphatase activity
K8U58_05825	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K8U58_05830	COG1609	Transcriptional regulator
K8U58_05835	COG3180	Ammonia monooxygenase
K8U58_05840	COG0477	Major facilitator Superfamily
K8U58_05840	COG2814	Major facilitator Superfamily
K8U58_05845	COG4533	DNA binding
K8U58_05855	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
K8U58_05860	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
K8U58_05865	COG1074	ATP-dependent DNA helicase activity
K8U58_05870	COG0420	3'-5' exonuclease activity
K8U58_05875	COG0419	ATPase involved in DNA repair
K8U58_05880	COG1403	HNH endonuclease
K8U58_05920	COG5337	Spore coat protein CotH
K8U58_05925	COG0179	Fumarylacetoacetate (FAA) hydrolase
K8U58_05935	COG1404	Belongs to the peptidase S8 family
K8U58_05945	COG0367	asparagine synthase
K8U58_05950	COG2318	DinB family
K8U58_05955	COG1562	ergosterol biosynthetic process
K8U58_05960	COG0534	Mate efflux family protein
K8U58_05965	COG2207	Transcriptional regulator
K8U58_05965	COG1917	Cupin 2, conserved barrel domain protein
K8U58_05970	COG1609	Transcriptional regulator
K8U58_05975	COG0673	inositol 2-dehydrogenase activity
K8U58_05980	COG2318	DinB family
K8U58_05985	COG1279	arginine transmembrane transporter activity
K8U58_05990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K8U58_05995	COG1357	PFAM Pentapeptide repeats (8 copies)
K8U58_06000	COG2267	carboxylic ester hydrolase activity
K8U58_06005	COG0529	Catalyzes the synthesis of activated sulfate
K8U58_06010	COG2046	Belongs to the sulfate adenylyltransferase family
K8U58_06015	COG0175	sulfate reduction
K8U58_06020	COG2045	Belongs to the ComB family
K8U58_06025	COG1809	phosphosulfolactate synthase activity
K8U58_06030	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K8U58_06035	COG4948	Mandelate Racemase Muconate Lactonizing
K8U58_06040	COG2814	Major facilitator Superfamily
K8U58_06045	COG0454	-acetyltransferase
K8U58_06050	COG2153	protein acetylation
K8U58_06055	COG0646	methionine synthase
K8U58_06055	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K8U58_06060	COG1666	GTP binding
K8U58_06065	COG2996	Protein conserved in bacteria
K8U58_06085	COG1695	Transcriptional regulator
K8U58_06100	COG3227	Zinc metalloprotease (Elastase)
K8U58_06105	COG1307	EDD domain protein, DegV family
K8U58_06110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K8U58_06130	COG0561	phosphatase activity
K8U58_06135	COG1073	alpha beta
K8U58_06140	COG2151	metal-sulfur cluster biosynthetic enzyme
K8U58_06150	COG0277	FAD linked oxidase domain protein
K8U58_06155	COG2271	Major facilitator Superfamily
K8U58_06160	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K8U58_06165	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
K8U58_06175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K8U58_06180	COG0505	Belongs to the CarA family
K8U58_06185	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K8U58_06190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
K8U58_06205	COG2267	carboxylic ester hydrolase activity
K8U58_06215	COG1744	ABC transporter substrate-binding protein PnrA-like
K8U58_06230	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K8U58_06235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K8U58_06240	COG5504	Zn-dependent protease
K8U58_06245	COG0444	Belongs to the ABC transporter superfamily
K8U58_06250	COG4608	Belongs to the ABC transporter superfamily
K8U58_06260	COG0601	transmembrane transport
K8U58_06265	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K8U58_06275	COG0180	Tryptophanyl-tRNA synthetase
K8U58_06280	COG4166	transmembrane transport
K8U58_06285	COG0601	transmembrane transport
K8U58_06290	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K8U58_06295	COG0444	Belongs to the ABC transporter superfamily
K8U58_06300	COG4608	Belongs to the ABC transporter superfamily
K8U58_06305	COG2814	Major facilitator Superfamily
K8U58_06310	COG0456	acetyltransferase
K8U58_06315	COG1393	Belongs to the ArsC family
K8U58_06320	COG0861	Integral membrane protein TerC family
K8U58_06330	COG4862	establishment of competence for transformation
K8U58_06340	COG4469	Competence protein
K8U58_06345	COG1164	Oligoendopeptidase f
K8U58_06355	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K8U58_06360	COG2346	COG2346, Truncated hemoglobins
K8U58_06365	COG0741	lytic transglycosylase activity
K8U58_06370	COG4116	CYTH
K8U58_06380	COG2357	RelA SpoT domain protein
K8U58_06385	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K8U58_06390	COG0564	pseudouridine synthase activity
K8U58_06395	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K8U58_06400	COG0475	glutathione-regulated potassium exporter activity
K8U58_06400	COG0569	domain protein
K8U58_06405	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
K8U58_06410	COG0352	thiamine-phosphate diphosphorylase activity
K8U58_06415	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K8U58_06420	COG2104	thiamine diphosphate biosynthetic process
K8U58_06425	COG2022	thiamine diphosphate biosynthetic process
K8U58_06430	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K8U58_06435	COG0351	phosphomethylpyrimidine kinase
K8U58_06440	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K8U58_06495	COG0210	DNA helicase
K8U58_06505	COG2153	protein acetylation
K8U58_06510	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
K8U58_06515	COG2382	esterase
K8U58_06520	COG0626	cystathionine gamma-synthase activity
K8U58_06525	COG0626	cystathionine gamma-synthase activity
K8U58_06530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K8U58_06535	COG5505	Protein of unknown function (DUF819)
K8U58_06570	COG3677	Transposase
K8U58_06585	COG5484	DNA packaging
K8U58_06590	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K8U58_06595	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_06605	COG3711	transcriptional antiterminator
K8U58_06605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8U58_06610	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K8U58_06610	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K8U58_06610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8U58_06615	COG1482	cell wall glycoprotein biosynthetic process
K8U58_06625	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K8U58_06635	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K8U58_06650	COG0109	protoheme IX farnesyltransferase activity
K8U58_06660	COG0726	polysaccharide deacetylase
K8U58_06675	COG5504	Zn-dependent protease
K8U58_06680	COG2205	protein histidine kinase activity
K8U58_06690	COG3383	formate dehydrogenase (NAD+) activity
K8U58_06695	COG2427	Protein of unknown function (DUF1641)
K8U58_06705	COG1051	belongs to the nudix hydrolase family
K8U58_06715	COG2124	cytochrome p450
K8U58_06720	COG1819	glycosyl
K8U58_06730	COG1587	Uroporphyrinogen-III synthase
K8U58_06735	COG0390	transport system, permease component
K8U58_06740	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K8U58_06745	COG0697	spore germination
K8U58_06750	COG4297	protein containing double-stranded beta helix domain
K8U58_06760	COG1252	NADH dehydrogenase
K8U58_06765	COG1904	glucuronate isomerase
K8U58_06770	COG2211	Major facilitator Superfamily
K8U58_06775	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
K8U58_06780	COG1063	alcohol dehydrogenase
K8U58_06785	COG1312	Catalyzes the dehydration of D-mannonate
K8U58_06790	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_06795	COG2271	Major facilitator Superfamily
K8U58_06800	COG1609	Transcriptional regulator
K8U58_06805	COG0246	Mannitol dehydrogenase
K8U58_06810	COG2721	sulfolactate sulfo-lyase activity
K8U58_06815	COG0730	response to heat
K8U58_06820	COG2318	DinB family
K8U58_06825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K8U58_06830	COG0457	Tetratricopeptide repeat
K8U58_06840	COG2350	Protein conserved in bacteria
K8U58_06845	COG1388	LysM domain
K8U58_06845	COG5632	N-Acetylmuramoyl-L-alanine amidase
K8U58_06845	COG3409	Peptidoglycan-binding domain 1 protein
K8U58_06855	COG4195	phage-related replication protein
K8U58_06860	COG3546	catalase activity
K8U58_06865	COG2856	Zn peptidase
K8U58_06870	COG1396	sequence-specific DNA binding
K8U58_06880	COG1522	sequence-specific DNA binding
K8U58_06885	COG1484	DNA-dependent DNA replication
K8U58_06905	COG1595	DNA-templated transcription, initiation
K8U58_06910	COG3728	DNA packaging
K8U58_06910	COG5484	DNA packaging
K8U58_06915	COG1783	phage Terminase large subunit
K8U58_06920	COG5518	Phage portal protein
K8U58_06925	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K8U58_06930	COG4653	Phage capsid family
K8U58_06980	COG3953	SLT domain
K8U58_06980	COG5412	phage tail tape measure protein
K8U58_06985	COG1652	LysM domain
K8U58_06990	COG4193	domain, Protein
K8U58_07000	COG3628	GPW Gp25 family protein
K8U58_07005	COG3299	homolog of phage Mu protein gp47
K8U58_07010	COG3778	Protein conserved in bacteria
K8U58_07050	COG3409	Peptidoglycan-binding domain 1 protein
K8U58_07050	COG5632	N-Acetylmuramoyl-L-alanine amidase
K8U58_07070	COG0306	phosphate transporter
K8U58_07075	COG1392	Phosphate transport regulator
K8U58_07080	COG0531	amino acid
K8U58_07085	COG0346	lactoylglutathione lyase activity
K8U58_07095	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K8U58_07100	COG0463	Glycosyl transferase, family 2
K8U58_07110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K8U58_07115	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K8U58_07120	COG2362	D-Aminopeptidase
K8U58_07125	COG0601	transmembrane transport
K8U58_07130	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K8U58_07135	COG0444	Belongs to the ABC transporter superfamily
K8U58_07140	COG4166	transmembrane transport
K8U58_07145	COG1619	proteins homologs of microcin C7 resistance protein MccF
K8U58_07150	COG4948	Mandelate Racemase Muconate Lactonizing
K8U58_07155	COG0791	NLP P60 protein
K8U58_07160	COG4608	Belongs to the ABC transporter superfamily
K8U58_07165	COG2706	6-phosphogluconolactonase activity
K8U58_07170	COG1834	amidinotransferase
K8U58_07175	COG1607	acyl-coa hydrolase
K8U58_07180	COG1017	nitric oxide dioxygenase activity
K8U58_07180	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K8U58_07190	COG2323	membrane
K8U58_07195	COG2318	DinB family
K8U58_07200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K8U58_07205	COG2076	Multidrug Resistance protein
K8U58_07210	COG2076	Multidrug Resistance protein
K8U58_07215	COG0788	formyltetrahydrofolate deformylase activity
K8U58_07220	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K8U58_07225	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K8U58_07230	COG1764	response to oxidative stress
K8U58_07235	COG1846	Transcriptional regulator
K8U58_07240	COG1764	response to oxidative stress
K8U58_07250	COG0590	tRNA wobble adenosine to inosine editing
K8U58_07255	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K8U58_07260	COG1404	Belongs to the peptidase S8 family
K8U58_07265	COG1366	Belongs to the anti-sigma-factor antagonist family
K8U58_07270	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
K8U58_07275	COG1122	ATPase activity
K8U58_07280	COG4721	ABC-type cobalt transport system, permease component
K8U58_07290	COG0745	RESPONSE REGULATOR receiver
K8U58_07295	COG3850	Histidine kinase
K8U58_07295	COG5002	protein histidine kinase activity
K8U58_07300	COG3212	peptidase
K8U58_07305	COG3212	peptidase
K8U58_07315	COG2239	Acts as a magnesium transporter
K8U58_07320	COG0789	Transcriptional regulator
K8U58_07335	COG1846	Transcriptional regulator
K8U58_07340	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K8U58_07345	COG0726	polysaccharide deacetylase
K8U58_07350	COG1408	metallophosphoesterase
K8U58_07360	COG0463	Glycosyl transferase, family 2
K8U58_07365	COG1793	dna ligase
K8U58_07365	COG3285	dna ligase
K8U58_07370	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
K8U58_07375	COG5001	Diguanylate cyclase
K8U58_07375	COG3300	MHYT domain
K8U58_07380	COG0586	Pfam SNARE associated Golgi protein
K8U58_07385	COG0861	Integral membrane protein TerC family
K8U58_07390	COG1191	sigma factor activity
K8U58_07410	COG0501	Belongs to the peptidase M48B family
K8U58_07415	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K8U58_07430	COG3594	Acyltransferase
K8U58_07435	COG5002	protein histidine kinase activity
K8U58_07440	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K8U58_07450	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
K8U58_07455	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
K8U58_07460	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K8U58_07465	COG0436	Aminotransferase
K8U58_07470	COG1850	ribulose-bisphosphate carboxylase activity
K8U58_07475	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
K8U58_07480	COG0235	Class ii aldolase
K8U58_07485	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
K8U58_07490	COG3339	Conserved Protein
K8U58_07505	COG3852	Histidine kinase
K8U58_07510	COG1846	Transcriptional regulator
K8U58_07515	COG1360	Flagellar Motor Protein
K8U58_07520	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K8U58_07525	COG0542	response to heat
K8U58_07530	COG3949	Membrane
K8U58_07535	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K8U58_07540	COG0720	synthase
K8U58_07545	COG0602	queuosine metabolic process
K8U58_07550	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K8U58_07555	COG1733	regulation of RNA biosynthetic process
K8U58_07560	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_07565	COG1388	LysM domain
K8U58_07565	COG4641	Protein conserved in bacteria
K8U58_07570	COG1388	LysM domain
K8U58_07585	COG4873	Protein conserved in bacteria
K8U58_07595	COG3773	Cell wall hydrolase
K8U58_07600	COG2244	polysaccharide biosynthetic process
K8U58_07605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8U58_07610	COG2217	Heavy metal translocating P-type atpase
K8U58_07620	COG0006	proline dipeptidase activity
K8U58_07625	COG1609	Transcriptional regulator
K8U58_07630	COG3711	transcriptional antiterminator
K8U58_07635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K8U58_07635	COG2190	(PTS) system
K8U58_07635	COG1263	PTS System
K8U58_07640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8U58_07645	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K8U58_07655	COG1533	DNA photolyase activity
K8U58_07660	COG0456	acetyltransferase
K8U58_07665	COG0840	transmembrane signaling receptor activity
K8U58_07670	COG2084	Dehydrogenase
K8U58_07675	COG2340	Cysteine-rich secretory protein family
K8U58_07680	COG0768	penicillin binding
K8U58_07685	COG4191	Histidine kinase
K8U58_07690	COG0436	Aminotransferase
K8U58_07700	COG0835	chemotaxis
K8U58_07700	COG0784	Response regulator, receiver
K8U58_07710	COG2814	Major facilitator Superfamily
K8U58_07715	COG1376	ErfK ybiS ycfS ynhG family protein
K8U58_07720	COG1408	metallophosphoesterase
K8U58_07725	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_07730	COG3409	Peptidoglycan-binding domain 1 protein
K8U58_07735	COG3409	Peptidoglycan-binding domain 1 protein
K8U58_07745	COG2200	EAL domain
K8U58_07750	COG4703	Protein of unknown function (DUF1797)
K8U58_07755	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
K8U58_07765	COG0517	IMP dehydrogenase activity
K8U58_07770	COG0583	DNA-binding transcription factor activity
K8U58_07775	COG0716	FMN binding
K8U58_07785	COG0716	FMN binding
K8U58_07790	COG2171	N-acyltransferase activity
K8U58_07795	COG1473	amidohydrolase
K8U58_07805	COG0668	transmembrane transport
K8U58_07810	COG0450	alkyl hydroperoxide reductase
K8U58_07815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8U58_07830	COG0746	molybdenum cofactor guanylyltransferase activity
K8U58_07835	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K8U58_07840	COG0303	'Molybdopterin
K8U58_07845	COG1763	Mo-molybdopterin cofactor biosynthetic process
K8U58_07850	COG0314	molybdopterin synthase activity
K8U58_07855	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K8U58_07860	COG1132	(ABC) transporter
K8U58_07865	COG1132	(ABC) transporter
K8U58_07875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8U58_07880	COG1136	(ABC) transporter
K8U58_07885	COG0577	efflux transmembrane transporter activity
K8U58_07890	COG1349	DNA-binding transcription factor activity
K8U58_07895	COG1105	Belongs to the carbohydrate kinase PfkB family
K8U58_07900	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8U58_07900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K8U58_07900	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
K8U58_07905	COG0681	Belongs to the peptidase S26 family
K8U58_07915	COG0488	(ABC) transporter
K8U58_07920	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K8U58_07925	COG2309	aminopeptidase activity
K8U58_07935	COG1077	Cell shape determining protein MreB Mrl
K8U58_07940	COG2002	toxin-antitoxin pair type II binding
K8U58_07945	COG3852	Histidine kinase
K8U58_07950	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
K8U58_07950	COG2105	PFAM AIG2 family protein
K8U58_07955	COG0569	domain protein
K8U58_07960	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
K8U58_07965	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K8U58_07970	COG5503	Protein of unknown function (DUF1447)
K8U58_07975	COG0561	phosphatase activity
K8U58_07980	COG0242	peptide deformylase activity
K8U58_07990	COG0497	DNA recombination
K8U58_07995	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K8U58_08000	COG0022	dehydrogenase e1 component
K8U58_08005	COG0508	dehydrogenase complex catalyzes the overall conversion of
K8U58_08010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K8U58_08015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8U58_08025	COG1982	Orn Lys Arg decarboxylase major
K8U58_08030	COG4476	Belongs to the UPF0223 family
K8U58_08035	COG4493	Belongs to the UPF0637 family
K8U58_08045	COG0483	inositol monophosphate 1-phosphatase activity
K8U58_08055	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K8U58_08075	COG1595	DNA-templated transcription, initiation
K8U58_08095	COG1217	gtp-binding protein TYPA
K8U58_08105	COG4896	Protein conserved in bacteria
K8U58_08115	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K8U58_08120	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K8U58_08125	COG2066	Belongs to the glutaminase family
K8U58_08130	COG4838	Belongs to the UPF0358 family
K8U58_08135	COG0772	Belongs to the SEDS family
K8U58_08140	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
K8U58_08145	COG1612	heme a metabolic process
K8U58_08150	COG0109	protoheme IX farnesyltransferase activity
K8U58_08155	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K8U58_08155	COG2010	Cytochrome c
K8U58_08160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K8U58_08165	COG1845	cytochrome c oxidase, subunit III
K8U58_08170	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K8U58_08175	COG3336	cytochrome c oxidase
K8U58_08185	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
K8U58_08190	COG2340	Cysteine-rich secretory protein family
K8U58_08205	COG3679	Belongs to the UPF0342 family
K8U58_08210	COG4471	UPF0298 protein
K8U58_08215	COG0742	ribosomal rna small subunit methyltransferase
K8U58_08220	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
K8U58_08225	COG3314	Sporulation integral membrane protein YlbJ
K8U58_08230	COG1752	Esterase of the alpha-beta hydrolase superfamily
K8U58_08235	COG3480	Lon protease (S16) C-terminal proteolytic domain
K8U58_08240	COG1323	Belongs to the UPF0348 family
K8U58_08250	COG1399	metal-binding, possibly nucleic acid-binding protein
K8U58_08265	COG0454	-acetyltransferase
K8U58_08270	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K8U58_08275	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
K8U58_08280	COG2001	Belongs to the MraZ family
K8U58_08285	COG0275	rRNA processing
K8U58_08290	COG4839	cell division protein FtsL
K8U58_08295	COG0768	penicillin binding
K8U58_08300	COG0768	penicillin binding
K8U58_08305	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K8U58_08310	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K8U58_08315	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K8U58_08320	COG0772	Belongs to the SEDS family
K8U58_08325	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K8U58_08330	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K8U58_08335	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K8U58_08340	COG3879	Bacterial protein of unknown function (DUF881)
K8U58_08345	COG3879	Bacterial protein of unknown function (DUF881)
K8U58_08350	COG3856	small basic protein
K8U58_08355	COG0849	cell division
K8U58_08360	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
K8U58_08365	COG1404	Belongs to the peptidase S8 family
K8U58_08365	COG4412	M6 family metalloprotease domain protein
K8U58_08375	COG1191	sigma factor activity
K8U58_08380	COG1191	sigma factor activity
K8U58_08385	COG1119	ATPase activity
K8U58_08390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K8U58_08395	COG1873	PFAM PRC-barrel domain
K8U58_08400	COG1496	oxidoreductase activity
K8U58_08405	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
K8U58_08410	COG1799	cell septum assembly
K8U58_08415	COG0762	integral membrane protein
K8U58_08420	COG2302	S4 RNA-binding domain
K8U58_08425	COG3599	regulation of cell shape
K8U58_08430	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K8U58_08435	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K8U58_08440	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K8U58_08445	COG0564	pseudouridine synthase activity
K8U58_08450	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
K8U58_08455	COG2233	PERMEase
K8U58_08460	COG0540	Belongs to the ATCase OTCase family
K8U58_08465	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K8U58_08470	COG0505	Belongs to the CarA family
K8U58_08475	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K8U58_08480	COG0543	2 iron, 2 sulfur cluster binding
K8U58_08485	COG0167	dihydroorotate dehydrogenase activity
K8U58_08490	COG0284	orotidine-5'-phosphate decarboxylase activity
K8U58_08495	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K8U58_08500	COG0175	sulfate reduction
K8U58_08505	COG0306	phosphate transporter
K8U58_08510	COG2046	Belongs to the sulfate adenylyltransferase family
K8U58_08515	COG0529	Catalyzes the synthesis of activated sulfate
K8U58_08520	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K8U58_08525	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
K8U58_08530	COG1648	precorrin-2 dehydrogenase activity
K8U58_08535	COG1293	RNA-binding protein homologous to eukaryotic snRNP
K8U58_08540	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K8U58_08545	COG1561	YicC-like family, N-terminal region
K8U58_08555	COG0194	GDP metabolic process
K8U58_08560	COG1758	RNA polymerase activity
K8U58_08565	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K8U58_08570	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K8U58_08575	COG0242	peptide deformylase activity
K8U58_08580	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K8U58_08585	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K8U58_08585	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K8U58_08590	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K8U58_08595	COG0631	protein serine/threonine phosphatase activity
K8U58_08600	COG2815	serine threonine protein kinase
K8U58_08600	COG0515	serine threonine protein kinase
K8U58_08605	COG1162	GTPase activity
K8U58_08610	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K8U58_08615	COG1564	THIamine pyrophosphokinase
K8U58_08625	COG0227	Belongs to the bacterial ribosomal protein bL28 family
K8U58_08630	COG1302	Protein conserved in bacteria
K8U58_08635	COG1461	Dihydroxyacetone kinase
K8U58_08640	COG1760	l-serine dehydratase
K8U58_08645	COG1760	l-serine dehydratase
K8U58_08650	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K8U58_08655	COG1349	DNA-binding transcription factor activity
K8U58_08655	COG2050	protein possibly involved in aromatic compounds catabolism
K8U58_08660	COG0416	fatty acid biosynthetic process
K8U58_08665	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K8U58_08670	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_08680	COG0571	ribonuclease III activity
K8U58_08685	COG1196	nuclear chromosome segregation
K8U58_08690	COG0552	protein localization to endoplasmic reticulum
K8U58_08700	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
K8U58_08705	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K8U58_08710	COG0228	four-way junction DNA binding
K8U58_08715	COG1837	Belongs to the UPF0109 family
K8U58_08725	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
K8U58_08730	COG0336	Belongs to the RNA methyltransferase TrmD family
K8U58_08735	COG0335	large ribosomal subunit rRNA binding
K8U58_08740	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K8U58_08745	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K8U58_08755	COG2257	FlhB HrpN YscU SpaS Family
K8U58_08760	COG0045	succinate-CoA ligase (ADP-forming) activity
K8U58_08765	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K8U58_08770	COG0758	DNA mediated transformation
K8U58_08775	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
K8U58_08780	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
K8U58_08785	COG4974	Belongs to the 'phage' integrase family
K8U58_08790	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K8U58_08795	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K8U58_08800	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
K8U58_08805	COG1815	bacterial-type flagellum-dependent cell motility
K8U58_08810	COG1558	bacterial-type flagellum-dependent cell motility
K8U58_08815	COG1677	Flagellar hook-basal body complex protein FliE
K8U58_08820	COG1766	The M ring may be actively involved in energy transduction
K8U58_08825	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K8U58_08830	COG1317	bacterial-type flagellum organization
K8U58_08835	COG1157	protein secretion by the type III secretion system
K8U58_08840	COG2882	bacterial-type flagellum organization
K8U58_08845	COG3334	PFAM MgtE intracellular
K8U58_08850	COG3144	bacterial-type flagellum assembly
K8U58_08855	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K8U58_08860	COG4786	Flagellar basal body rod
K8U58_08865	COG1582	Flagellar protein (FlbD)
K8U58_08870	COG1580	Controls the rotational direction of flagella during chemotaxis
K8U58_08875	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K8U58_08880	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K8U58_08880	COG1776	CheC inhibitor of MCP methylation
K8U58_08885	COG2201	protein-glutamate methylesterase activity
K8U58_08890	COG3190	flagellar
K8U58_08895	COG1338	Plays a role in the flagellum-specific transport system
K8U58_08900	COG1987	bacterial-type flagellum assembly
K8U58_08905	COG1684	flagellar biosynthetic protein fliR
K8U58_08910	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K8U58_08915	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K8U58_08920	COG1419	protein localization to endoplasmic reticulum
K8U58_08925	COG0455	bacterial-type flagellum organization
K8U58_08930	COG2201	protein-glutamate methylesterase activity
K8U58_08935	COG0643	Histidine kinase
K8U58_08935	COG2198	Histidine kinase
K8U58_08940	COG0835	chemotaxis
K8U58_08945	COG1776	CheC inhibitor of MCP methylation
K8U58_08950	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
K8U58_08955	COG1191	sigma factor activity
K8U58_08965	COG0052	Belongs to the universal ribosomal protein uS2 family
K8U58_08970	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K8U58_08975	COG0528	UMP kinase activity
K8U58_08980	COG0233	cytoplasmic translational termination
K8U58_08985	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K8U58_08990	COG4589	Belongs to the CDS family
K8U58_08995	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
K8U58_09000	COG0750	zinc metalloprotease
K8U58_09005	COG0442	prolyl-tRNA aminoacylation
K8U58_09010	COG2176	DNA-directed DNA polymerase activity
K8U58_09015	COG0779	Required for maturation of 30S ribosomal subunits
K8U58_09020	COG0195	Participates in both transcription termination and antitermination
K8U58_09025	COG2740	Nucleic-acid-binding protein implicated in transcription termination
K8U58_09030	COG1358	cellular component organization or biogenesis
K8U58_09035	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K8U58_09040	COG1550	Protein conserved in bacteria
K8U58_09045	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K8U58_09050	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
K8U58_09055	COG0196	riboflavin kinase activity
K8U58_09060	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
K8U58_09065	COG1185	polyribonucleotide nucleotidyltransferase activity
K8U58_09070	COG0726	polysaccharide deacetylase
K8U58_09075	COG0612	Peptidase, M16
K8U58_09080	COG1873	PFAM PRC-barrel domain
K8U58_09085	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K8U58_09090	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K8U58_09095	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
K8U58_09100	COG0527	aspartate kinase activity
K8U58_09105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K8U58_09110	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
K8U58_09115	COG0740	serine-type endopeptidase activity
K8U58_09125	COG4980	gas vesicle protein
K8U58_09125	COG1674	ftsk spoiiie
K8U58_09130	COG2188	Transcriptional regulator
K8U58_09135	COG2814	Major facilitator Superfamily
K8U58_09140	COG0612	Peptidase, M16
K8U58_09145	COG0612	Peptidase, M16
K8U58_09150	COG0300	oxidoreductase activity
K8U58_09165	COG1426	Protein conserved in bacteria
K8U58_09170	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K8U58_09175	COG1546	Belongs to the CinA family
K8U58_09175	COG1058	Belongs to the CinA family
K8U58_09180	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K8U58_09185	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K8U58_09190	COG1418	mRNA catabolic process
K8U58_09195	COG1692	metallophosphoesterase
K8U58_09200	COG2359	stage V sporulation protein S
K8U58_09205	COG1063	alcohol dehydrogenase
K8U58_09210	COG0156	8-amino-7-oxononanoate synthase activity
K8U58_09215	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K8U58_09220	COG4550	Control of competence regulator ComK, YlbF/YmcA
K8U58_09230	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K8U58_09235	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K8U58_09250	COG3226	Transcriptional regulator
K8U58_09255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8U58_09265	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K8U58_09270	COG3321	synthase
K8U58_09275	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
K8U58_09275	COG2070	2-Nitropropane dioxygenase
K8U58_09280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K8U58_09285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K8U58_09290	COG3425	synthase
K8U58_09295	COG1024	Enoyl-CoA hydratase
K8U58_09300	COG1024	Enoyl-CoA hydratase
K8U58_09305	COG3321	synthase
K8U58_09305	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_09305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K8U58_09305	COG0318	PFAM AMP-dependent synthetase and ligase
K8U58_09305	COG0300	oxidoreductase activity
K8U58_09310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K8U58_09310	COG0300	oxidoreductase activity
K8U58_09310	COG3321	synthase
K8U58_09310	COG4221	oxidoreductase activity
K8U58_09315	COG3321	synthase
K8U58_09315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K8U58_09315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K8U58_09315	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_09315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K8U58_09320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K8U58_09320	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_09320	COG3321	synthase
K8U58_09320	COG4221	oxidoreductase activity
K8U58_09325	COG3321	synthase
K8U58_09325	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K8U58_09325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K8U58_09325	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
K8U58_09330	COG2124	cytochrome p450
K8U58_09340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8U58_09345	COG1404	Belongs to the peptidase S8 family
K8U58_09350	COG4195	phage-related replication protein
K8U58_09355	COG1764	response to oxidative stress
K8U58_09360	COG2076	Multidrug Resistance protein
K8U58_09365	COG2076	Multidrug Resistance protein
K8U58_09380	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K8U58_09385	COG1923	regulation of RNA biosynthetic process
K8U58_09400	COG1780	Probably involved in ribonucleotide reductase function
K8U58_09405	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K8U58_09410	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K8U58_09415	COG4112	unkown
K8U58_09420	COG0860	N-Acetylmuramoyl-L-alanine amidase
K8U58_09425	COG0464	growth
K8U58_09430	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K8U58_09435	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
K8U58_09440	COG0789	Transcriptional regulator
K8U58_09445	COG0174	glutamine synthetase
K8U58_09465	COG4282	regulation of fungal-type cell wall biogenesis
K8U58_09475	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K8U58_09505	COG0135	phosphoribosylanthranilate isomerase activity
K8U58_09510	COG2211	Major facilitator Superfamily
K8U58_09515	COG3507	Belongs to the glycosyl hydrolase 43 family
K8U58_09520	COG1940	carbohydrate kinase activity
K8U58_09525	COG2115	Belongs to the xylose isomerase family
K8U58_09530	COG1070	Carbohydrate kinase
K8U58_09540	COG1525	nuclease
K8U58_09545	COG2814	Major facilitator Superfamily
K8U58_09550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K8U58_09560	COG0756	dUTP diphosphatase activity
K8U58_09575	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K8U58_09600	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
K8U58_09615	COG3832	glyoxalase III activity
K8U58_09625	COG0697	spore germination
K8U58_09630	COG0531	amino acid
K8U58_09660	COG4195	phage-related replication protein
K8U58_09670	COG0346	lactoylglutathione lyase activity
K8U58_09675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K8U58_09680	COG1388	LysM domain
K8U58_09685	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K8U58_09690	COG4224	UPF0291 protein
K8U58_09695	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K8U58_09705	COG3763	UPF0154 protein
K8U58_09715	COG0785	Cytochrome C biogenesis protein
K8U58_09720	COG2201	protein-glutamate methylesterase activity
K8U58_09725	COG4846	Membrane protein involved in cytochrome C biogenesis
K8U58_09735	COG0071	Belongs to the small heat shock protein (HSP20) family
K8U58_09750	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K8U58_09755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8U58_09775	COG0824	Thioesterase
K8U58_09785	COG4841	protein insertion into membrane
K8U58_09790	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K8U58_09795	COG1832	CoA-binding protein
K8U58_09800	COG0187	DNA topoisomerase II activity
K8U58_09805	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K8U58_09815	COG1115	amino acid carrier protein
K8U58_09820	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
K8U58_09830	COG5520	Belongs to the glycosyl hydrolase 30 family
K8U58_09835	COG3507	Belongs to the glycosyl hydrolase 43 family
K8U58_09840	COG2246	polysaccharide biosynthetic process
K8U58_09845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K8U58_09850	COG0586	Pfam SNARE associated Golgi protein
K8U58_09855	COG2404	hydrolase activity, acting on ester bonds
K8U58_09860	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K8U58_09865	COG1024	Enoyl-CoA hydratase
K8U58_09870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K8U58_09875	COG0511	ligase activity, forming carbon-carbon bonds
K8U58_09880	COG0439	Biotin carboxylase
K8U58_09885	COG0318	PFAM AMP-dependent synthetase and ligase
K8U58_09890	COG1960	acyl-CoA dehydrogenase activity
K8U58_09905	COG1649	PFAM Uncharacterised BCR, COG1649
K8U58_09915	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
K8U58_09915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K8U58_09920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K8U58_09925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K8U58_09930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K8U58_09935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K8U58_09940	COG2027	D-alanyl-D-alanine carboxypeptidase
K8U58_09945	COG2017	converts alpha-aldose to the beta-anomer
K8U58_09950	COG0534	Mate efflux family protein
K8U58_09965	COG0582	viral genome integration into host DNA
K8U58_09970	COG0166	Belongs to the GPI family
K8U58_09975	COG0405	Gamma-glutamyltransferase
K8U58_09980	COG0583	DNA-binding transcription factor activity
K8U58_09985	COG0604	alcohol dehydrogenase
K8U58_09990	COG0493	'glutamate synthase
K8U58_09995	COG0069	glutamate synthase activity
K8U58_09995	COG0070	glutamate synthase
K8U58_09995	COG0067	glutamate synthase
K8U58_10000	COG0583	DNA-binding transcription factor activity
K8U58_10005	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
K8U58_10010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K8U58_10020	COG0300	oxidoreductase activity
K8U58_10025	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
K8U58_10035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K8U58_10040	COG2814	Major facilitator Superfamily
K8U58_10045	COG1070	Carbohydrate kinase
K8U58_10050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K8U58_10055	COG0243	molybdopterin cofactor binding
K8U58_10085	COG0840	transmembrane signaling receptor activity
K8U58_10085	COG5278	phosphoserine phosphatase activity
K8U58_10090	COG2368	4-hydroxyphenylacetate
K8U58_10095	COG4305	rare lipoprotein A
K8U58_10100	COG3619	membrane
K8U58_10105	COG3866	Pectate lyase
K8U58_10110	COG2135	peptidase activity
K8U58_10120	COG2140	Oxalate decarboxylase
K8U58_10135	COG0456	acetyltransferase
K8U58_10155	COG2720	vancomycin resistance protein
K8U58_10165	COG3655	Transcriptional regulator
K8U58_10170	COG3739	integral membrane protein
K8U58_10175	COG0583	DNA-binding transcription factor activity
K8U58_10180	COG0697	spore germination
K8U58_10190	COG0693	protein deglycase activity
K8U58_10195	COG2367	Beta-lactamase
K8U58_10210	COG0574	Belongs to the PEP-utilizing enzyme family
K8U58_10210	COG3848	Pyruvate phosphate dikinase
K8U58_10215	COG0726	polysaccharide deacetylase
K8U58_10220	COG2314	TM2 domain
K8U58_10225	COG1396	sequence-specific DNA binding
K8U58_10245	COG2135	peptidase activity
K8U58_10285	COG0457	Tetratricopeptide repeat
K8U58_10310	COG5290	Psort location Cytoplasmic, score
K8U58_10335	COG5444	nuclease activity
K8U58_10340	COG4282	regulation of fungal-type cell wall biogenesis
K8U58_10345	COG1231	oxidoreductase activity
K8U58_10350	COG5434	Belongs to the glycosyl hydrolase 28 family
K8U58_10355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K8U58_10360	COG2207	Transcriptional regulator
K8U58_10360	COG0662	Cupin 2, conserved barrel domain protein
K8U58_10365	COG0456	acetyltransferase
K8U58_10370	COG1309	transcriptional regulator
K8U58_10375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8U58_10380	COG3708	Transcriptional regulator
K8U58_10385	COG2378	regulation of single-species biofilm formation
K8U58_10395	COG0640	Transcriptional regulator
K8U58_10400	COG0741	lytic transglycosylase activity
K8U58_10405	COG2322	membrane
K8U58_10420	COG1619	proteins homologs of microcin C7 resistance protein MccF
K8U58_10425	COG3239	Fatty acid desaturase
K8U58_10430	COG4585	Histidine kinase
K8U58_10435	COG2197	response regulator
K8U58_10440	COG3584	3D domain protein
K8U58_10440	COG1388	LysM domain
K8U58_10445	COG0514	ATP-dependent DNA helicase (RecQ)
K8U58_10455	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K8U58_10460	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K8U58_10475	COG0071	Belongs to the small heat shock protein (HSP20) family
K8U58_10500	COG1012	belongs to the aldehyde dehydrogenase family
K8U58_10505	COG1657	PFAM Prenyltransferase squalene oxidase
K8U58_10510	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K8U58_10515	COG0733	neurotransmitter:sodium symporter activity
K8U58_10520	COG0385	Bile acid
K8U58_10525	COG0508	dehydrogenase complex catalyzes the overall conversion of
K8U58_10530	COG0567	Dehydrogenase, E1 component
K8U58_10535	COG4548	von Willebrand factor, type A
K8U58_10540	COG0714	Associated with various cellular activities
K8U58_10545	COG2032	superoxide dismutase activity
K8U58_10550	COG1388	LysM domain
K8U58_10550	COG0791	NLP P60 protein
K8U58_10555	COG1819	glycosyl
K8U58_10560	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
K8U58_10565	COG0534	Mate efflux family protein
K8U58_10570	COG1366	Belongs to the anti-sigma-factor antagonist family
K8U58_10575	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K8U58_10580	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K8U58_10590	COG2962	Rard protein
K8U58_10605	COG2610	gluconate transmembrane transporter activity
K8U58_10610	COG1942	4-Oxalocrotonate Tautomerase
K8U58_10615	COG1733	regulation of RNA biosynthetic process
K8U58_10620	COG0778	Nitroreductase
K8U58_10625	COG0400	carboxylic ester hydrolase activity
K8U58_10630	COG0346	lactoylglutathione lyase activity
K8U58_10640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K8U58_10645	COG3409	Peptidoglycan-binding domain 1 protein
K8U58_10645	COG0793	Belongs to the peptidase S41A family
K8U58_10650	COG2226	methyltransferase
K8U58_10660	COG1876	peptidase activity
K8U58_10665	COG0813	purine-nucleoside phosphorylase activity
K8U58_10680	COG0671	phosphoesterase, PA-phosphatase related
K8U58_10700	COG4479	Belongs to the UPF0346 family
K8U58_10710	COG1509	lysine 2,3-aminomutase activity
K8U58_10715	COG0456	acetyltransferase
K8U58_10720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K8U58_10725	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K8U58_10730	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K8U58_10735	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K8U58_10750	COG0456	acetyltransferase
K8U58_10755	COG0463	Glycosyl transferase, family 2
K8U58_10770	COG4641	Protein conserved in bacteria
K8U58_10775	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
K8U58_10780	COG1086	Polysaccharide biosynthesis protein
K8U58_10790	COG3331	DNA recombination
K8U58_10845	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K8U58_10880	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
K8U58_10885	COG0756	dUTP diphosphatase activity
K8U58_10890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8U58_10915	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K8U58_10915	COG1372	Participates in initiation and elongation during chromosome replication
K8U58_10920	COG1780	Probably involved in ribonucleotide reductase function
K8U58_11010	COG0270	DNA (cytosine-5-)-methyltransferase activity
K8U58_11020	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
K8U58_11025	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K8U58_11050	COG3584	3D domain protein
K8U58_11055	COG0587	DNA-directed DNA polymerase activity
K8U58_11060	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K8U58_11065	COG0358	DNA primase activity
K8U58_11070	COG0305	Participates in initiation and elongation during chromosome replication
K8U58_11080	COG2887	Belongs to the helicase family. UvrD subfamily
K8U58_11110	COG5434	Belongs to the glycosyl hydrolase 28 family
K8U58_11110	COG3420	alginic acid biosynthetic process
K8U58_11115	COG4195	phage-related replication protein
K8U58_11130	COG2135	peptidase activity
K8U58_11135	COG1793	dna ligase
K8U58_11190	COG4474	Belongs to the UPF0398 family
K8U58_11200	COG1388	LysM domain
K8U58_11220	COG3645	SOS response
K8U58_11220	COG3646	Phage regulatory protein
K8U58_11275	COG3655	Transcriptional regulator
K8U58_11290	COG0582	viral genome integration into host DNA
K8U58_11370	COG3655	Transcriptional regulator
K8U58_11410	COG1395	domain, Protein
K8U58_11425	COG0776	regulation of translation
K8U58_11460	COG4373	Mu-like prophage FluMu protein gp28
K8U58_11560	COG0582	viral genome integration into host DNA
K8U58_11590	COG0739	heme binding
K8U58_11590	COG0741	lytic transglycosylase activity
K8U58_11590	COG1196	nuclear chromosome segregation
K8U58_11600	COG2433	Pfam Transposase IS66
K8U58_11610	COG5434	Belongs to the glycosyl hydrolase 28 family
K8U58_11610	COG4632	Exopolysaccharide biosynthesis protein
K8U58_11625	COG5632	N-Acetylmuramoyl-L-alanine amidase
K8U58_11640	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K8U58_11645	COG0463	Glycosyl transferase, family 2
K8U58_11650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8U58_11655	COG2274	protein secretion by the type I secretion system
K8U58_11655	COG3271	cysteine-type peptidase activity
K8U58_11670	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K8U58_11700	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K8U58_11715	COG5444	nuclease activity
K8U58_11720	COG4282	regulation of fungal-type cell wall biogenesis
K8U58_11735	COG1525	nuclease
K8U58_11745	COG2746	aminoglycoside 3-N-acetyltransferase activity
K8U58_11770	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K8U58_11775	COG1086	Polysaccharide biosynthesis protein
K8U58_11780	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K8U58_11785	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K8U58_11790	COG1846	Transcriptional regulator
K8U58_11795	COG0534	Mate efflux family protein
K8U58_11805	COG4698	Protein conserved in bacteria
K8U58_11810	COG2755	lipolytic protein G-D-S-L family
K8U58_11815	COG1999	signal sequence binding
K8U58_11825	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K8U58_11830	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K8U58_11835	COG1272	protein, Hemolysin III
K8U58_11840	COG0204	Acyl-transferase
K8U58_11845	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K8U58_11850	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K8U58_11855	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K8U58_11865	COG2521	methyltransferase
K8U58_11865	COG2136	Putative SAM-dependent methyltransferase
K8U58_11875	COG0129	dihydroxy-acid dehydratase activity
K8U58_11880	COG1413	lyase activity
K8U58_11885	COG1418	mRNA catabolic process
K8U58_11890	COG0386	Belongs to the glutathione peroxidase family
K8U58_11895	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
K8U58_11900	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K8U58_11910	COG1278	Cold shock
K8U58_11930	COG0328	RNA-DNA hybrid ribonuclease activity
K8U58_11935	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
K8U58_11940	COG0328	RNA-DNA hybrid ribonuclease activity
K8U58_11950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K8U58_11965	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K8U58_11975	COG1755	Isoprenylcysteine carboxyl methyltransferase
K8U58_11980	COG3424	synthase
K8U58_11985	COG2233	PERMEase
K8U58_11990	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K8U58_11995	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
K8U58_12005	COG0800	Aldolase
K8U58_12010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K8U58_12015	COG1609	Transcriptional regulator
K8U58_12020	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
K8U58_12025	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_12030	COG1199	ATP-dependent helicase activity
K8U58_12045	COG0116	Belongs to the methyltransferase superfamily
K8U58_12060	COG4474	Belongs to the UPF0398 family
K8U58_12075	COG3359	exonuclease
K8U58_12080	COG1205	dead DEAH box helicase
K8U58_12080	COG1111	helicase
K8U58_12085	COG2190	(PTS) system
K8U58_12090	COG0071	Belongs to the small heat shock protein (HSP20) family
K8U58_12125	COG3331	DNA recombination
K8U58_12130	COG4499	WXG100 protein secretion system (Wss), protein YukC
K8U58_12130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K8U58_12140	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K8U58_12145	COG3935	DnaD domain protein
K8U58_12150	COG0017	Asparaginyl-tRNA synthetase
K8U58_12155	COG0436	Aminotransferase
K8U58_12160	COG5353	protein conserved in bacteria
K8U58_12170	COG1199	ATP-dependent helicase activity
K8U58_12170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K8U58_12175	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K8U58_12180	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K8U58_12185	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
K8U58_12190	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K8U58_12190	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K8U58_12195	COG0617	tRNA 3'-terminal CCA addition
K8U58_12200	COG0438	transferase activity, transferring glycosyl groups
K8U58_12205	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
K8U58_12210	COG1803	Methylglyoxal synthase
K8U58_12215	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K8U58_12220	COG1694	Mazg nucleotide pyrophosphohydrolase
K8U58_12225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K8U58_12235	COG4347	Protein of unknown function (DUF1405)
K8U58_12240	COG2010	Cytochrome c
K8U58_12240	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K8U58_12245	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K8U58_12250	COG0723	plastoquinol--plastocyanin reductase activity
K8U58_12260	COG5582	Belongs to the UPF0302 family
K8U58_12265	COG0457	Tetratricopeptide repeat
K8U58_12270	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K8U58_12275	COG0287	Prephenate dehydrogenase
K8U58_12280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
K8U58_12285	COG0159	tryptophan synthase activity
K8U58_12290	COG0133	tryptophan synthase activity
K8U58_12295	COG0135	phosphoribosylanthranilate isomerase activity
K8U58_12305	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K8U58_12310	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K8U58_12315	COG4401	Chorismate mutase type I
K8U58_12320	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K8U58_12325	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K8U58_12330	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K8U58_12335	COG0105	UTP biosynthetic process
K8U58_12340	COG0142	geranyltranstransferase activity
K8U58_12345	COG2226	methyltransferase
K8U58_12350	COG0142	geranyltranstransferase activity
K8U58_12360	COG0302	gtp cyclohydrolase
K8U58_12365	COG0776	regulation of translation
K8U58_12370	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
K8U58_12385	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K8U58_12390	COG1160	GTP binding
K8U58_12415	COG1304	FMN binding
K8U58_12420	COG0539	negative regulation of cytoplasmic translation
K8U58_12425	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K8U58_12435	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
K8U58_12440	COG2959	enzyme of heme biosynthesis
K8U58_12445	COG3773	Cell wall hydrolase
K8U58_12445	COG3409	Peptidoglycan-binding domain 1 protein
K8U58_12450	COG2339	peptidase activity
K8U58_12455	COG0492	ferredoxin-NADP+ reductase activity
K8U58_12460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K8U58_12465	COG4862	establishment of competence for transformation
K8U58_12470	COG1408	metallophosphoesterase
K8U58_12480	COG1388	LysM domain
K8U58_12485	COG1266	CAAX protease self-immunity
K8U58_12490	COG0514	ATP-dependent DNA helicase (RecQ)
K8U58_12495	COG4955	Helix-turn-helix domain
K8U58_12500	COG1141	Ferredoxin
K8U58_12505	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
K8U58_12510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K8U58_12515	COG0710	3-dehydroquinate dehydratase activity
K8U58_12525	COG1595	DNA-templated transcription, initiation
K8U58_12530	COG5002	protein histidine kinase activity
K8U58_12535	COG0745	RESPONSE REGULATOR receiver
K8U58_12540	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K8U58_12545	COG1333	cytochrome c biogenesis protein
K8U58_12550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8U58_12555	COG1187	pseudouridine synthase activity
K8U58_12560	COG0700	Nucleoside recognition
K8U58_12565	COG2715	membrane protein required for spore maturation
K8U58_12570	COG1686	Belongs to the peptidase S11 family
K8U58_12580	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K8U58_12585	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K8U58_12590	COG1547	Domain of unknown function (DUF309)
K8U58_12595	COG0456	acetyltransferase
K8U58_12600	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
K8U58_12605	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K8U58_12605	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K8U58_12610	COG0307	riboflavin synthase, alpha
K8U58_12615	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K8U58_12615	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K8U58_12625	COG0681	Belongs to the peptidase S26 family
K8U58_12635	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
K8U58_12650	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K8U58_12655	COG4086	secreted protein
K8U58_12660	COG0019	diaminopimelate decarboxylase activity
K8U58_12665	COG0697	spore germination
K8U58_12680	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K8U58_12700	COG1191	sigma factor activity
K8U58_12705	COG2172	sigma factor antagonist activity
K8U58_12710	COG1366	Belongs to the anti-sigma-factor antagonist family
K8U58_12715	COG1686	Belongs to the peptidase S11 family
K8U58_12720	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
K8U58_12725	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
K8U58_12730	COG4974	Belongs to the 'phage' integrase family
K8U58_12740	COG0735	belongs to the Fur family
K8U58_12745	COG1300	Membrane
K8U58_12755	COG0281	malic enzyme
K8U58_12760	COG1757	Na H antiporter
K8U58_12765	COG1027	Aspartate ammonia-lyase
K8U58_12770	COG0252	asparaginase activity
K8U58_12775	COG1396	sequence-specific DNA binding
K8U58_12780	COG1379	DNA repair
K8U58_12785	COG0494	nUDIX hydrolase
K8U58_12795	COG0667	Aldo Keto reductase
K8U58_12805	COG1073	alpha beta
K8U58_12815	COG4918	Iron-sulphur cluster biosynthesis
K8U58_12820	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
K8U58_12820	COG0456	acetyltransferase
K8U58_12825	COG2329	Antibiotic biosynthesis monooxygenase
K8U58_12830	COG0456	acetyltransferase
K8U58_12840	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K8U58_12850	COG2211	Major facilitator Superfamily
K8U58_12860	COG0346	lactoylglutathione lyase activity
K8U58_12865	COG1072	(Pantothenic acid kinase))
K8U58_12870	COG3048	D-serine ammonia-lyase activity
K8U58_12875	COG0300	oxidoreductase activity
K8U58_12880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8U58_12885	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K8U58_12890	COG4187	Peptidase family M20/M25/M40
K8U58_12895	COG1902	pentaerythritol trinitrate reductase activity
K8U58_12900	COG0596	Alpha beta hydrolase
K8U58_12910	COG1234	tRNA 3'-trailer cleavage
K8U58_12915	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K8U58_12920	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K8U58_12925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K8U58_12935	COG0706	membrane insertase activity
K8U58_12940	COG3361	conserved protein (COG2071)
K8U58_12945	COG2195	Cleaves the N-terminal amino acid of tripeptides
K8U58_12950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K8U58_12955	COG0346	lactoylglutathione lyase activity
K8U58_12965	COG1376	ErfK ybiS ycfS ynhG family protein
K8U58_12970	COG4129	membrane
K8U58_12975	COG1126	abc transporter atp-binding protein
K8U58_12980	COG0765	amino acid transport
K8U58_12985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K8U58_12995	COG1597	lipid kinase activity
K8U58_13000	COG2814	Major facilitator Superfamily
K8U58_13005	COG0789	Transcriptional regulator
K8U58_13005	COG4978	Transcriptional regulator
K8U58_13010	COG0508	dehydrogenase complex catalyzes the overall conversion of
K8U58_13015	COG0022	dehydrogenase e1 component
K8U58_13020	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K8U58_13025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K8U58_13030	COG3426	butyrate kinase activity
K8U58_13035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K8U58_13040	COG0280	phosphate acetyltransferase
K8U58_13045	COG3290	protein histidine kinase activity
K8U58_13045	COG3829	transcription factor binding
K8U58_13055	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
K8U58_13060	COG2079	MmgE PrpD family protein
K8U58_13065	COG0372	Belongs to the citrate synthase family
K8U58_13070	COG1960	acyl-CoA dehydrogenase activity
K8U58_13075	COG1250	3-hydroxyacyl-CoA dehydrogenase
K8U58_13080	COG0183	Belongs to the thiolase family
K8U58_13085	COG0584	glycerophosphoryl diester phosphodiesterase
K8U58_13090	COG0860	N-Acetylmuramoyl-L-alanine amidase
K8U58_13105	COG1902	pentaerythritol trinitrate reductase activity
K8U58_13110	COG0745	RESPONSE REGULATOR receiver
K8U58_13115	COG0750	zinc metalloprotease
K8U58_13120	COG0497	DNA recombination
K8U58_13125	COG1438	arginine binding
K8U58_13130	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
K8U58_13135	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K8U58_13140	COG0142	geranyltranstransferase activity
K8U58_13145	COG1722	exodeoxyribonuclease VII activity
K8U58_13150	COG1570	exodeoxyribonuclease VII activity
K8U58_13155	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K8U58_13160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K8U58_13165	COG1302	Protein conserved in bacteria
K8U58_13170	COG0439	Biotin carboxylase
K8U58_13175	COG0511	ligase activity, forming carbon-carbon bonds
K8U58_13215	COG3854	ATPases associated with a variety of cellular activities
K8U58_13225	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K8U58_13230	COG0006	proline dipeptidase activity
K8U58_13235	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K8U58_13245	COG3872	metal-dependent enzyme
K8U58_13255	COG1752	Esterase of the alpha-beta hydrolase superfamily
K8U58_13260	COG1321	iron dependent repressor
K8U58_13265	COG0095	Lipoate-protein ligase
K8U58_13270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K8U58_13275	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K8U58_13280	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K8U58_13285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K8U58_13290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K8U58_13305	COG1396	sequence-specific DNA binding
K8U58_13315	COG0681	Belongs to the peptidase S26 family
K8U58_13340	COG4940	Competence protein ComGF
K8U58_13350	COG4970	Tfp pilus assembly protein FimT
K8U58_13355	COG4537	Required for transformation and DNA binding
K8U58_13360	COG1459	type II secretion system
K8U58_13365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
K8U58_13370	COG0598	Magnesium transport protein CorA
K8U58_13375	COG1253	flavin adenine dinucleotide binding
K8U58_13380	COG1366	Belongs to the anti-sigma-factor antagonist family
K8U58_13390	COG1393	Belongs to the ArsC family
K8U58_13400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8U58_13410	COG0011	TIGRFAM Protein of
K8U58_13420	COG2866	Carboxypeptidase
K8U58_13425	COG1368	sulfuric ester hydrolase activity
K8U58_13430	COG1940	carbohydrate kinase activity
K8U58_13435	COG4483	Protein conserved in bacteria
K8U58_13440	COG0705	Rhomboid family
K8U58_13440	COG0457	Tetratricopeptide repeat
K8U58_13450	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K8U58_13460	COG0438	transferase activity, transferring glycosyl groups
K8U58_13475	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K8U58_13480	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K8U58_13485	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
K8U58_13490	COG0581	inorganic phosphate transmembrane transporter activity
K8U58_13495	COG0573	inorganic phosphate transmembrane transporter activity
K8U58_13500	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K8U58_13505	COG0768	penicillin binding
K8U58_13510	COG0477	Major facilitator Superfamily
K8U58_13515	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K8U58_13520	COG2839	Protein conserved in bacteria
K8U58_13525	COG5521	maltodextrose utilization protein MalA
K8U58_13535	COG1388	LysM domain
K8U58_13540	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K8U58_13545	COG4709	membrane
K8U58_13550	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
K8U58_13555	COG0735	belongs to the Fur family
K8U58_13560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K8U58_13570	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
K8U58_13575	COG0513	Belongs to the DEAD box helicase family
K8U58_13585	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K8U58_13590	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K8U58_13595	COG2384	SAM-dependent methyltransferase
K8U58_13600	COG2010	Cytochrome c
K8U58_13605	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K8U58_13610	COG0358	DNA primase activity
K8U58_13615	COG1671	Belongs to the UPF0178 family
K8U58_13620	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K8U58_13625	COG0517	IMP dehydrogenase activity
K8U58_13630	COG0751	glycine-tRNA ligase activity
K8U58_13635	COG0752	glycyl-tRNA synthetase alpha subunit
K8U58_13640	COG1381	Involved in DNA repair and RecF pathway recombination
K8U58_13650	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K8U58_13655	COG0295	cytidine deaminase activity
K8U58_13660	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
K8U58_13665	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
K8U58_13670	COG1480	7TM receptor with intracellular HD hydrolase
K8U58_13675	COG1702	phosphate starvation-inducible protein PhoH
K8U58_13680	COG0561	phosphatase activity
K8U58_13695	COG4864	UPF0365 protein
K8U58_13700	COG1030	water channel activity
K8U58_13705	COG1610	YqeY-like protein
K8U58_13715	COG1283	sodium-dependent phosphate transmembrane transporter activity
K8U58_13720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K8U58_13725	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K8U58_13730	COG2264	protein methyltransferase activity
K8U58_13735	COG0484	heat shock protein binding
K8U58_13740	COG0443	Heat shock 70 kDa protein
K8U58_13745	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K8U58_13750	COG1420	regulation of RNA biosynthetic process
K8U58_13755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K8U58_13760	COG0481	GTPase activity
K8U58_13770	COG0860	N-Acetylmuramoyl-L-alanine amidase
K8U58_13775	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
K8U58_13780	COG0268	Binds directly to 16S ribosomal RNA
K8U58_13785	COG1466	dna polymerase III delta subunit
K8U58_13800	COG2333	competence protein COMEC
K8U58_13800	COG0658	competence protein
K8U58_13805	COG2131	deaminase
K8U58_13810	COG1555	photosystem II stabilization
K8U58_13810	COG1596	polysaccharide export
K8U58_13815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
K8U58_13820	COG2226	methyltransferase
K8U58_13825	COG0799	negative regulation of ribosome biogenesis
K8U58_13830	COG1713	HD superfamily hydrolase involved in NAD metabolism
K8U58_13835	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K8U58_13840	COG1534	Rna-binding protein
K8U58_13845	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K8U58_13850	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
K8U58_13855	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
K8U58_13865	COG2755	lipolytic protein G-D-S-L family
K8U58_13870	COG5632	N-Acetylmuramoyl-L-alanine amidase
K8U58_13870	COG3409	Peptidoglycan-binding domain 1 protein
K8U58_13875	COG0398	Pfam SNARE associated Golgi protein
K8U58_13880	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
K8U58_13890	COG3209	COG3209 Rhs family protein
K8U58_13900	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
K8U58_13905	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K8U58_13910	COG0798	PFAM Bile acid sodium symporter
K8U58_13915	COG0346	lactoylglutathione lyase activity
K8U58_13920	COG0640	Transcriptional regulator
K8U58_13925	COG3403	YqcI/YcgG family
K8U58_13930	COG0457	Tetratricopeptide repeat
K8U58_13945	COG5444	nuclease activity
K8U58_13970	COG5632	N-Acetylmuramoyl-L-alanine amidase
K8U58_13970	COG3409	Peptidoglycan-binding domain 1 protein
K8U58_13975	COG4824	toxin secretion phage lysis holin
K8U58_14005	COG3778	Protein conserved in bacteria
K8U58_14010	COG3299	homolog of phage Mu protein gp47
K8U58_14015	COG3628	GPW Gp25 family protein
K8U58_14025	COG4193	domain, Protein
K8U58_14030	COG1652	LysM domain
K8U58_14035	COG5280	Phage tail tape measure protein TP901
K8U58_14035	COG3953	SLT domain
K8U58_14100	COG4653	Phage capsid family
K8U58_14105	COG0338	D12 class N6 adenine-specific DNA methyltransferase
K8U58_14115	COG2369	cell adhesion
K8U58_14120	COG5518	Phage portal protein
K8U58_14125	COG1783	phage Terminase large subunit
K8U58_14130	COG5484	DNA packaging
K8U58_14140	COG3677	Transposase
K8U58_14155	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
K8U58_14165	COG1484	DNA-dependent DNA replication
K8U58_14170	COG3935	DnaD domain protein
K8U58_14175	COG3723	Recombinational DNA repair protein, rece pathway
K8U58_14180	COG5377	YqaJ viral recombinase family
K8U58_14210	COG1476	TRANSCRIPTIONal
K8U58_14215	COG3620	sequence-specific DNA binding
K8U58_14225	COG0563	adenylate kinase activity
K8U58_14230	COG2856	Zn peptidase
K8U58_14255	COG3223	Belongs to the PsiE family
K8U58_14260	COG5002	protein histidine kinase activity
K8U58_14260	COG0642	Histidine kinase
K8U58_14265	COG0745	RESPONSE REGULATOR receiver
K8U58_14270	COG2311	Membrane
K8U58_14280	COG0454	-acetyltransferase
K8U58_14285	COG2249	NAD(P)H dehydrogenase (quinone) activity
K8U58_14295	COG0730	response to heat
K8U58_14300	COG0425	Belongs to the sulfur carrier protein TusA family
K8U58_14305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K8U58_14305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8U58_14315	COG0425	Belongs to the sulfur carrier protein TusA family
K8U58_14315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K8U58_14320	COG2210	Belongs to the sulfur carrier protein TusA family
K8U58_14325	COG1937	Protein conserved in bacteria
K8U58_14330	COG0662	Cupin 2, conserved barrel domain protein
K8U58_14340	COG0789	Transcriptional regulator
K8U58_14340	COG4978	Transcriptional regulator
K8U58_14345	COG2814	Major facilitator Superfamily
K8U58_14350	COG0456	acetyltransferase
K8U58_14355	COG1253	flavin adenine dinucleotide binding
K8U58_14365	COG0697	spore germination
K8U58_14370	COG0583	DNA-binding transcription factor activity
K8U58_14375	COG2072	flavoprotein involved in K transport
K8U58_14380	COG1230	cation diffusion facilitator family transporter
K8U58_14385	COG1942	4-Oxalocrotonate Tautomerase
K8U58_14390	COG0583	DNA-binding transcription factor activity
K8U58_14400	COG1114	Component of the transport system for branched-chain amino acids
K8U58_14405	COG1687	branched-chain amino acid
K8U58_14410	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
K8U58_14415	COG1522	sequence-specific DNA binding
K8U58_14420	COG2732	(Barnase) inhibitor
K8U58_14425	COG2124	cytochrome p450
K8U58_14435	COG1335	isochorismatase
K8U58_14450	COG2318	DinB family
K8U58_14460	COG2070	2-Nitropropane dioxygenase
K8U58_14465	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K8U58_14485	COG3443	Belongs to the bacterial solute-binding protein 9 family
K8U58_14490	COG1595	DNA-templated transcription, initiation
K8U58_14495	COG0667	Aldo Keto reductase
K8U58_14500	COG2851	Citrate transporter
K8U58_14505	COG0583	DNA-binding transcription factor activity
K8U58_14510	COG2828	Protein conserved in bacteria
K8U58_14515	COG3409	Peptidoglycan-binding domain 1 protein
K8U58_14520	COG5566	PFAM Mor transcription activator
K8U58_14525	COG0596	Alpha beta hydrolase
K8U58_14530	COG4991	sh3 domain protein
K8U58_14535	COG4991	sh3 domain protein
K8U58_14545	COG0346	lactoylglutathione lyase activity
K8U58_14555	COG5577	PFAM Coat F domain
K8U58_14560	COG1063	alcohol dehydrogenase
K8U58_14570	COG5577	PFAM Coat F domain
K8U58_14575	COG0789	Transcriptional regulator
K8U58_14585	COG1064	alcohol dehydrogenase
K8U58_14590	COG0693	protein deglycase activity
K8U58_14595	COG1621	beta-fructofuranosidase activity
K8U58_14600	COG3716	PTS system mannose fructose sorbose family IID component
K8U58_14605	COG3715	PTS system
K8U58_14610	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K8U58_14615	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8U58_14620	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
K8U58_14620	COG3933	PFAM sigma-54 factor interaction domain-containing protein
K8U58_14630	COG1113	amino acid transport
K8U58_14635	COG1280	lysine exporter protein (LysE YggA)
K8U58_14640	COG1378	Sugar-specific transcriptional regulator TrmB
K8U58_14645	COG1595	DNA-templated transcription, initiation
K8U58_14655	COG2755	lipolytic protein G-D-S-L family
K8U58_14655	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K8U58_14665	COG2124	cytochrome p450
K8U58_14665	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K8U58_14670	COG1309	transcriptional regulator
K8U58_14675	COG2226	methyltransferase
K8U58_14690	COG2116	formate transmembrane transporter activity
K8U58_14695	COG5609	conserved protein (DUF2294)
K8U58_14700	COG3383	formate dehydrogenase (NAD+) activity
K8U58_14705	COG2427	Protein of unknown function (DUF1641)
K8U58_14715	COG0626	cystathionine gamma-synthase activity
K8U58_14720	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K8U58_14725	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K8U58_14730	COG2226	methyltransferase
K8U58_14745	COG0768	penicillin binding
K8U58_14750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K8U58_14755	COG0572	uridine kinase
K8U58_14760	COG0826	peptidase U32
K8U58_14765	COG0826	peptidase U32
K8U58_14770	COG4122	O-methyltransferase activity
K8U58_14775	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K8U58_14780	COG3906	Belongs to the UPF0473 family
K8U58_14785	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
K8U58_14790	COG4472	Bacterial protein of unknown function (DUF965)
K8U58_14795	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K8U58_14800	COG0628	permease
K8U58_14805	COG1126	abc transporter atp-binding protein
K8U58_14810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K8U58_14815	COG0765	amino acid transport
K8U58_14820	COG0765	amino acid transport
K8U58_14835	COG3881	PFAM PRC-barrel domain
K8U58_14840	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K8U58_14845	COG0457	Tetratricopeptide repeat
K8U58_14850	COG0482	sulfurtransferase activity
K8U58_14855	COG1104	cysteine desulfurase activity
K8U58_14860	COG1959	2 iron, 2 sulfur cluster binding
K8U58_14865	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K8U58_14870	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K8U58_14880	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K8U58_14885	COG0124	histidyl-tRNA synthetase
K8U58_14895	COG0860	N-Acetylmuramoyl-L-alanine amidase
K8U58_14895	COG3103	Sh3 type 3 domain protein
K8U58_14895	COG4991	sh3 domain protein
K8U58_14900	COG1490	D-aminoacyl-tRNA deacylase activity
K8U58_14905	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K8U58_14910	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
K8U58_14915	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
K8U58_14915	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K8U58_14920	COG5416	Lipopolysaccharide assembly protein A domain
K8U58_14925	COG0490	domain, Protein
K8U58_14930	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K8U58_14930	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K8U58_14940	COG2244	polysaccharide biosynthetic process
K8U58_14945	COG2323	membrane
K8U58_14955	COG1862	Preprotein translocase
K8U58_14960	COG0343	queuine tRNA-ribosyltransferase activity
K8U58_14965	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K8U58_14975	COG2255	four-way junction helicase activity
K8U58_14980	COG0632	four-way junction helicase activity
K8U58_14990	COG2814	Major facilitator Superfamily
K8U58_14995	COG0673	inositol 2-dehydrogenase activity
K8U58_15000	COG2112	serine threonine protein kinase
K8U58_15020	COG1115	amino acid carrier protein
K8U58_15025	COG0217	transcriptional regulatory protein
K8U58_15035	COG1388	LysM domain
K8U58_15040	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
K8U58_15045	COG0157	Belongs to the NadC ModD family
K8U58_15050	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K8U58_15055	COG1104	cysteine desulfurase activity
K8U58_15060	COG1827	regulation of RNA biosynthetic process
K8U58_15065	COG0077	Prephenate dehydratase
K8U58_15070	COG4492	Belongs to the UPF0735 family
K8U58_15075	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K8U58_15080	COG3290	protein histidine kinase activity
K8U58_15090	COG0211	Belongs to the bacterial ribosomal protein bL27 family
K8U58_15095	COG2868	ribosomal protein
K8U58_15100	COG0261	This protein binds to 23S rRNA in the presence of protein L20
K8U58_15105	COG1994	Peptidase M50
K8U58_15110	COG0739	heme binding
K8U58_15115	COG2894	cell division
K8U58_15120	COG0850	regulation of cytokinetic process
K8U58_15125	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
K8U58_15135	COG1077	Cell shape determining protein MreB Mrl
K8U58_15140	COG2003	Belongs to the UPF0758 family
K8U58_15145	COG0424	maF-like protein
K8U58_15155	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K8U58_15160	COG0285	dihydrofolate synthase activity
K8U58_15165	COG0525	valine-tRNA ligase activity
K8U58_15175	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K8U58_15180	COG1388	LysM domain
K8U58_15185	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K8U58_15190	COG0113	porphobilinogen synthase activity
K8U58_15195	COG1587	Uroporphyrinogen-III synthase
K8U58_15200	COG0181	hydroxymethylbilane synthase activity
K8U58_15205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K8U58_15210	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K8U58_15220	COG0218	Necessary for normal cell division and for the maintenance of normal septation
K8U58_15225	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K8U58_15230	COG0470	DNA polymerase III
K8U58_15230	COG1067	ATP-dependent peptidase activity
K8U58_15235	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
K8U58_15240	COG0544	peptidyl-prolyl cis-trans isomerase activity
K8U58_15245	COG1477	protein flavinylation
K8U58_15245	COG0457	Tetratricopeptide repeat
K8U58_15250	COG0066	3-isopropylmalate dehydratase activity
K8U58_15255	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
K8U58_15260	COG0473	3-isopropylmalate dehydrogenase activity
K8U58_15265	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K8U58_15270	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K8U58_15275	COG0440	acetolactate synthase activity
K8U58_15280	COG0028	Belongs to the TPP enzyme family
K8U58_15290	COG0454	-acetyltransferase
K8U58_15295	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
K8U58_15305	COG0622	Phosphoesterase
K8U58_15310	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K8U58_15315	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K8U58_15320	COG5401	PFAM Sporulation and spore germination
K8U58_15325	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K8U58_15330	COG1846	Transcriptional regulator
K8U58_15335	COG2197	response regulator
K8U58_15340	COG0824	Thioesterase
K8U58_15345	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K8U58_15350	COG1053	succinate dehydrogenase
K8U58_15355	COG2009	succinate dehydrogenase
K8U58_15360	COG1719	4-vinyl reductase, 4VR
K8U58_15365	COG0527	aspartate kinase activity
K8U58_15370	COG0322	excinuclease ABC activity
K8U58_15375	COG3118	belongs to the thioredoxin family
K8U58_15380	COG3534	alpha-L-arabinofuranosidase
K8U58_15385	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K8U58_15390	COG2086	electron transfer activity
K8U58_15395	COG1024	Enoyl-CoA hydratase
K8U58_15400	COG1309	transcriptional regulator
K8U58_15405	COG0318	PFAM AMP-dependent synthetase and ligase
K8U58_15410	COG3766	membrane
K8U58_15415	COG1193	negative regulation of DNA recombination
K8U58_15420	COG1796	DNA polymerase
K8U58_15420	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K8U58_15425	COG1286	toxin biosynthetic process
K8U58_15430	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
K8U58_15435	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K8U58_15440	COG0072	phenylalanine-tRNA ligase activity
K8U58_15440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K8U58_15445	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K8U58_15455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K8U58_15465	COG3835	regulator
K8U58_15470	COG0277	FAD linked oxidase domain protein
K8U58_15475	COG0247	lactate metabolic process
K8U58_15480	COG0346	lactoylglutathione lyase activity
K8U58_15490	COG1966	Carbon starvation protein
K8U58_15495	COG3534	alpha-L-arabinofuranosidase
K8U58_15500	COG0395	ABC-type sugar transport system, permease component
K8U58_15505	COG1175	transmembrane transport
K8U58_15510	COG1653	transport
K8U58_15515	COG0371	Dehydrogenase
K8U58_15520	COG0647	UMP catabolic process
K8U58_15525	COG0235	Class ii aldolase
K8U58_15530	COG1069	ribulokinase activity
K8U58_15535	COG2160	L-arabinose isomerase activity
K8U58_15540	COG3507	Belongs to the glycosyl hydrolase 43 family
K8U58_15545	COG1363	Peptidase, m42
K8U58_15555	COG3326	Membrane
K8U58_15560	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
K8U58_15565	COG0291	Belongs to the bacterial ribosomal protein bL35 family
K8U58_15570	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K8U58_15580	COG1346	cytolysis
K8U58_15585	COG1380	Effector of murein hydrolase LrgA
K8U58_15590	COG3279	Response regulator of the LytR AlgR family
K8U58_15595	COG3275	phosphorelay sensor kinase activity
K8U58_15600	COG1011	Hydrolase
K8U58_15605	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K8U58_15615	COG0398	Pfam SNARE associated Golgi protein
K8U58_15620	COG1484	DNA-dependent DNA replication
K8U58_15625	COG3611	Membrane attachment protein
K8U58_15630	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K8U58_15635	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K8U58_15640	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K8U58_15645	COG1733	regulation of RNA biosynthetic process
K8U58_15650	COG2814	Major facilitator Superfamily
K8U58_15655	COG0656	L-ascorbic acid biosynthetic process
K8U58_15660	COG0237	dephospho-CoA kinase activity
K8U58_15665	COG1971	Probably functions as a manganese efflux pump
K8U58_15670	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K8U58_15675	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K8U58_15675	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
K8U58_15680	COG5002	protein histidine kinase activity
K8U58_15685	COG0745	RESPONSE REGULATOR receiver
K8U58_15690	COG0039	L-malate dehydrogenase activity
K8U58_15695	COG0538	isocitrate dehydrogenase activity
K8U58_15700	COG0372	Belongs to the citrate synthase family
K8U58_15705	COG2707	UPF0756 membrane protein
K8U58_15710	COG0628	permease
K8U58_15715	COG3030	protein affecting phage T7 exclusion by the F plasmid
K8U58_15720	COG0469	pyruvate kinase activity
K8U58_15725	COG0205	6-phosphofructokinase activity
K8U58_15730	COG0825	malonyl-CoA metabolic process
K8U58_15735	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K8U58_15740	COG0281	malic enzyme
K8U58_15745	COG0587	DNA-directed DNA polymerase activity
K8U58_15765	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
K8U58_15775	COG4109	DRTGG domain
K8U58_15780	COG0730	response to heat
K8U58_15785	COG1473	amidohydrolase
K8U58_15790	COG0196	riboflavin kinase activity
K8U58_15795	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K8U58_15800	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
K8U58_15805	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K8U58_15810	COG1126	abc transporter atp-binding protein
K8U58_15815	COG0765	amino acid transport
K8U58_15820	COG0765	amino acid transport
K8U58_15825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K8U58_15830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K8U58_15835	COG0454	-acetyltransferase
K8U58_15840	COG0583	DNA-binding transcription factor activity
K8U58_15845	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
K8U58_15850	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_15855	COG0165	Argininosuccinate lyase
K8U58_15860	COG0137	argininosuccinate synthase activity
K8U58_15865	COG0521	Mo-molybdopterin cofactor biosynthetic process
K8U58_15870	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K8U58_15880	COG0827	DNA restriction-modification system
K8U58_15885	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
K8U58_15890	COG3874	Sporulation protein YtfJ
K8U58_15900	COG1714	RDD family
K8U58_15905	COG0616	signal peptide processing
K8U58_15910	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K8U58_15915	COG1574	metal-dependent hydrolase with the TIM-barrel fold
K8U58_15920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K8U58_15930	COG0301	tRNA thio-modification
K8U58_15935	COG1104	cysteine desulfurase activity
K8U58_15940	COG1114	Component of the transport system for branched-chain amino acids
K8U58_15945	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
K8U58_15950	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K8U58_15955	COG1309	transcriptional regulator
K8U58_15960	COG1956	GAF domain-containing protein
K8U58_15965	COG2203	Gaf domain
K8U58_15965	COG2199	diguanylate cyclase activity
K8U58_15970	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
K8U58_15975	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K8U58_15980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K8U58_15985	COG0454	-acetyltransferase
K8U58_15990	COG0517	IMP dehydrogenase activity
K8U58_15995	COG0123	including yeast histone deacetylase and acetoin utilization protein
K8U58_16000	COG1360	Flagellar Motor Protein
K8U58_16005	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K8U58_16010	COG1609	Transcriptional regulator
K8U58_16015	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
K8U58_16015	COG1605	Chorismate mutase
K8U58_16020	COG3118	belongs to the thioredoxin family
K8U58_16025	COG4980	gas vesicle protein
K8U58_16030	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
K8U58_16035	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K8U58_16040	COG1674	ftsk spoiiie
K8U58_16045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K8U58_16050	COG4848	Belongs to the UPF0354 family
K8U58_16055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8U58_16070	COG1363	Peptidase, m42
K8U58_16075	COG5584	Small secreted protein
K8U58_16080	COG0281	malic enzyme
K8U58_16085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8U58_16090	COG0220	tRNA (guanine-N7-)-methyltransferase activity
K8U58_16100	COG0510	thiamine kinase activity
K8U58_16105	COG1523	belongs to the glycosyl hydrolase 13 family
K8U58_16110	COG1597	lipid kinase activity
K8U58_16120	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
K8U58_16125	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
K8U58_16130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K8U58_16135	COG2252	PERMEase
K8U58_16140	COG4473	ABC transporter
K8U58_16145	COG1131	(ABC) transporter
K8U58_16150	COG1349	DNA-binding transcription factor activity
K8U58_16155	COG1187	pseudouridine synthase activity
K8U58_16160	COG2244	polysaccharide biosynthetic process
K8U58_16165	COG2081	HI0933 family
K8U58_16170	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K8U58_16180	COG5578	integral membrane protein
K8U58_16185	COG0673	inositol 2-dehydrogenase activity
K8U58_16190	COG1653	transport
K8U58_16195	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
K8U58_16200	COG4209	transmembrane transport
K8U58_16205	COG2207	Transcriptional regulator
K8U58_16210	COG1653	transport
K8U58_16215	COG0395	ABC-type sugar transport system, permease component
K8U58_16220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K8U58_16225	COG2124	cytochrome p450
K8U58_16230	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K8U58_16235	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K8U58_16240	COG0156	8-amino-7-oxononanoate synthase activity
K8U58_16245	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K8U58_16250	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
K8U58_16255	COG1073	alpha beta
K8U58_16260	COG1609	Transcriptional regulator
K8U58_16265	COG1653	transport
K8U58_16270	COG1175	transmembrane transport
K8U58_16275	COG0395	ABC-type sugar transport system, permease component
K8U58_16280	COG1486	melibiose metabolic process
K8U58_16285	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K8U58_16290	COG0495	leucyl-tRNA aminoacylation
K8U58_16300	COG2202	Pas domain
K8U58_16300	COG1366	Belongs to the anti-sigma-factor antagonist family
K8U58_16305	COG2814	Major facilitator Superfamily
K8U58_16310	COG2433	Pfam Transposase IS66
K8U58_16315	COG0577	efflux transmembrane transporter activity
K8U58_16320	COG1136	(ABC) transporter
K8U58_16325	COG2205	protein histidine kinase activity
K8U58_16330	COG0745	RESPONSE REGULATOR receiver
K8U58_16335	COG0577	efflux transmembrane transporter activity
K8U58_16340	COG1136	(ABC) transporter
K8U58_16355	COG1131	(ABC) transporter
K8U58_16360	COG1725	Transcriptional regulator
K8U58_16375	COG1242	4 iron, 4 sulfur cluster binding
K8U58_16380	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
K8U58_16390	COG2267	carboxylic ester hydrolase activity
K8U58_16395	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
K8U58_16400	COG1113	amino acid transport
K8U58_16405	COG0367	asparagine synthase
K8U58_16410	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K8U58_16415	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
K8U58_16425	COG1506	peptidase
K8U58_16430	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K8U58_16435	COG1116	anion transmembrane transporter activity
K8U58_16440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K8U58_16445	COG0494	nUDIX hydrolase
K8U58_16450	COG4824	toxin secretion phage lysis holin
K8U58_16455	COG0783	Belongs to the Dps family
K8U58_16470	COG1854	S-ribosylhomocysteine lyase activity
K8U58_16475	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K8U58_16480	COG0288	reversible hydration of carbon dioxide
K8U58_16485	COG0254	rRNA binding
K8U58_16490	COG1271	oxidase subunit
K8U58_16495	COG1294	oxidase, subunit
K8U58_16505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K8U58_16510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K8U58_16510	COG1321	iron dependent repressor
K8U58_16515	COG1121	(ABC) transporter
K8U58_16520	COG0803	Belongs to the bacterial solute-binding protein 9 family
K8U58_16525	COG4948	Mandelate Racemase Muconate Lactonizing
K8U58_16530	COG0318	PFAM AMP-dependent synthetase and ligase
K8U58_16535	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
K8U58_16540	COG0596	Alpha beta hydrolase
K8U58_16545	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
K8U58_16550	COG1169	isochorismate synthase
K8U58_16555	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
K8U58_16560	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K8U58_16565	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K8U58_16570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K8U58_16575	COG0438	transferase activity, transferring glycosyl groups
K8U58_16585	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K8U58_16590	COG0438	transferase activity, transferring glycosyl groups
K8U58_16595	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K8U58_16600	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
K8U58_16605	COG0058	SHG alpha-glucan phosphorylase activity
K8U58_16610	COG0297	glycogen (starch) synthase activity
K8U58_16615	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K8U58_16620	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
K8U58_16625	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K8U58_16750	COG3859	Proton-coupled thiamine transporter YuaJ
K8U58_16755	COG1247	-acetyltransferase
K8U58_16760	COG2268	Band 7 protein
K8U58_16765	COG1585	Membrane protein implicated in regulation of membrane protease activity
K8U58_16770	COG2318	DinB family
K8U58_16780	COG1454	alcohol dehydrogenase
K8U58_16785	COG1012	belongs to the aldehyde dehydrogenase family
K8U58_16790	COG1510	regulation of RNA biosynthetic process
K8U58_16800	COG0569	domain protein
K8U58_16805	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
K8U58_16810	COG4682	membrane
K8U58_16815	COG1705	Flagellar rod assembly protein muramidase FlgJ
K8U58_16820	COG0477	Major facilitator Superfamily
K8U58_16825	COG5553	Cysteine dioxygenase type I
K8U58_16835	COG1968	undecaprenyl-diphosphatase activity
K8U58_16840	COG0628	permease
K8U58_16845	COG0673	inositol 2-dehydrogenase activity
K8U58_16850	COG4806	L-rhamnose isomerase
K8U58_16855	COG3254	rhamnose metabolic process
K8U58_16860	COG1070	Carbohydrate kinase
K8U58_16865	COG1349	DNA-binding transcription factor activity
K8U58_16870	COG3347	Dehydrogenase
K8U58_16870	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_16875	COG0840	transmembrane signaling receptor activity
K8U58_16880	COG0840	transmembrane signaling receptor activity
K8U58_16885	COG0840	transmembrane signaling receptor activity
K8U58_16890	COG0840	transmembrane signaling receptor activity
K8U58_16905	COG0432	Pfam Uncharacterised protein family UPF0047
K8U58_16915	COG0366	Alpha amylase catalytic
K8U58_16920	COG1253	flavin adenine dinucleotide binding
K8U58_16925	COG2738	Putative neutral zinc metallopeptidase
K8U58_16940	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K8U58_16955	COG0166	Belongs to the GPI family
K8U58_16960	COG1979	alcohol dehydrogenase
K8U58_16965	COG1979	alcohol dehydrogenase
K8U58_16970	COG2155	Conserved Protein
K8U58_16975	COG1098	S1 RNA binding domain
K8U58_16980	COG0436	Aminotransferase
K8U58_16985	COG1522	sequence-specific DNA binding
K8U58_16990	COG2267	carboxylic ester hydrolase activity
K8U58_17000	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
K8U58_17005	COG2205	protein histidine kinase activity
K8U58_17015	COG5018	Exonuclease
K8U58_17020	COG2814	Major facilitator Superfamily
K8U58_17025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K8U58_17030	COG3011	Protein conserved in bacteria
K8U58_17040	COG3290	protein histidine kinase activity
K8U58_17045	COG4565	transcriptional regulatory protein
K8U58_17050	COG1744	ABC transporter substrate-binding protein PnrA-like
K8U58_17055	COG3845	ABC transporter
K8U58_17060	COG4603	Belongs to the binding-protein-dependent transport system permease family
K8U58_17065	COG1079	Belongs to the binding-protein-dependent transport system permease family
K8U58_17070	COG3493	citrate carrier protein
K8U58_17080	COG2111	Na H antiporter
K8U58_17080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
K8U58_17085	COG2111	Na H antiporter
K8U58_17090	COG1006	Multisubunit Na H antiporter MnhC subunit
K8U58_17095	COG0651	ATP synthesis coupled electron transport
K8U58_17100	COG1863	multisubunit Na H antiporter MnhE subunit
K8U58_17105	COG2212	antiporter activity
K8U58_17110	COG1320	monovalent cation:proton antiporter activity
K8U58_17115	COG2050	protein possibly involved in aromatic compounds catabolism
K8U58_17120	COG2197	response regulator
K8U58_17125	COG4585	Histidine kinase
K8U58_17135	COG0142	geranyltranstransferase activity
K8U58_17155	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
K8U58_17160	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
K8U58_17165	COG1335	isochorismatase
K8U58_17170	COG5506	Protein of unknown function (DUF1694)
K8U58_17185	COG0628	permease
K8U58_17200	COG1418	mRNA catabolic process
K8U58_17205	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_17215	COG1511	domain protein
K8U58_17220	COG1674	ftsk spoiiie
K8U58_17220	COG0433	COG0433 Predicted ATPase
K8U58_17225	COG4499	WXG100 protein secretion system (Wss), protein YukC
K8U58_17230	COG5417	Belongs to the EsaB family
K8U58_17235	COG4842	Belongs to the WXG100 family
K8U58_17240	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
K8U58_17240	COG2508	Transcriptional regulator
K8U58_17245	COG0686	Belongs to the AlaDH PNT family
K8U58_17250	COG5634	Uncharacterized conserved protein (DUF2278)
K8U58_17255	COG3251	PFAM MbtH domain protein
K8U58_17260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K8U58_17265	COG3433	isochorismatase activity
K8U58_17265	COG1535	isochorismatase
K8U58_17270	COG1021	2,3-dihydroxybenzoate-AMP ligase
K8U58_17275	COG1169	isochorismate synthase
K8U58_17280	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_17285	COG2819	hydrolase of the alpha beta superfamily
K8U58_17290	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K8U58_17295	COG1268	BioY protein
K8U58_17300	COG2056	Na+-H+ antiporter family
K8U58_17305	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K8U58_17310	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
K8U58_17315	COG3584	3D domain protein
K8U58_17330	COG1252	NADH dehydrogenase
K8U58_17335	COG0492	ferredoxin-NADP+ reductase activity
K8U58_17345	COG0516	GMP reductase activity
K8U58_17350	COG2808	Putative FMN-binding domain
K8U58_17355	COG0456	acetyltransferase
K8U58_17360	COG0316	Belongs to the HesB IscA family
K8U58_17365	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K8U58_17370	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K8U58_17375	COG4844	belongs to the
K8U58_17380	COG1252	NADH dehydrogenase
K8U58_17385	COG4837	Protein of unknown function (DUF1462)
K8U58_17390	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
K8U58_17395	COG4946	Tricorn protease homolog
K8U58_17395	COG1506	peptidase
K8U58_17395	COG0823	Involved in the tonB-independent uptake of proteins
K8U58_17400	COG0083	homoserine kinase activity
K8U58_17405	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
K8U58_17410	COG0460	homoserine dehydrogenase
K8U58_17415	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K8U58_17420	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K8U58_17425	COG0647	UMP catabolic process
K8U58_17430	COG2445	Protein of unknown function DUF86
K8U58_17435	COG4470	Protein conserved in bacteria
K8U58_17445	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K8U58_17450	COG0739	heme binding
K8U58_17460	COG3377	Domain of unknown function (DUF1805)
K8U58_17465	COG0737	Belongs to the 5'-nucleotidase family
K8U58_17470	COG0730	response to heat
K8U58_17475	COG1801	Protein of unknown function DUF72
K8U58_17485	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K8U58_17490	COG2508	Transcriptional regulator
K8U58_17495	COG2233	PERMEase
K8U58_17500	COG2233	PERMEase
K8U58_17505	COG3195	allantoin biosynthetic process
K8U58_17505	COG3648	Uricase
K8U58_17510	COG2351	hydroxyisourate hydrolase activity
K8U58_17520	COG2080	2 iron, 2 sulfur cluster binding
K8U58_17525	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K8U58_17530	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K8U58_17535	COG2068	MobA-Related Protein
K8U58_17540	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
K8U58_17545	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K8U58_17550	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K8U58_17560	COG2356	endonuclease I
K8U58_17565	COG3842	ATPase activity
K8U58_17570	COG2188	Transcriptional regulator
K8U58_17575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K8U58_17580	COG0395	ABC-type sugar transport system, permease component
K8U58_17585	COG1175	transmembrane transport
K8U58_17590	COG1653	transport
K8U58_17595	COG2222	sugar isomerase
K8U58_17600	COG0322	excinuclease ABC activity
K8U58_17605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K8U58_17620	COG0346	lactoylglutathione lyase activity
K8U58_17625	COG0640	Transcriptional regulator
K8U58_17630	COG0719	Fe-S assembly protein
K8U58_17635	COG0822	iron-sulfur transferase activity
K8U58_17640	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K8U58_17645	COG0719	Fe-S assembly protein
K8U58_17650	COG0396	ATPase activity
K8U58_17660	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K8U58_17665	COG1464	Belongs to the NlpA lipoprotein family
K8U58_17670	COG2011	ABC-type metal ion transport system permease component
K8U58_17675	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
K8U58_17685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K8U58_17690	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
K8U58_17700	COG0509	glycine decarboxylation via glycine cleavage system
K8U58_17705	COG1393	Belongs to the ArsC family
K8U58_17710	COG1960	acyl-CoA dehydrogenase activity
K8U58_17715	COG0183	Belongs to the thiolase family
K8U58_17720	COG1250	3-hydroxyacyl-CoA dehydrogenase
K8U58_17720	COG1024	Enoyl-CoA hydratase
K8U58_17730	COG0506	proline dehydrogenase activity
K8U58_17740	COG5577	PFAM Coat F domain
K8U58_17745	COG1846	Transcriptional regulator
K8U58_17750	COG0477	Major facilitator Superfamily
K8U58_17755	COG1942	4-Oxalocrotonate Tautomerase
K8U58_17765	COG0583	DNA-binding transcription factor activity
K8U58_17775	COG1120	ATPase activity
K8U58_17790	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_17795	COG0783	Belongs to the Dps family
K8U58_17800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K8U58_17805	COG0745	RESPONSE REGULATOR receiver
K8U58_17810	COG2770	Histidine kinase
K8U58_17810	COG2205	protein histidine kinase activity
K8U58_17820	COG1309	transcriptional regulator
K8U58_17825	COG0114	fumarate hydratase activity
K8U58_17835	COG0697	spore germination
K8U58_17840	COG0814	amino acid
K8U58_17850	COG2197	response regulator
K8U58_17855	COG4585	Histidine kinase
K8U58_17860	COG4758	membrane
K8U58_17865	COG3595	metallopeptidase activity
K8U58_17870	COG1842	Phage shock protein A
K8U58_17875	COG4758	membrane
K8U58_17880	COG2814	Major facilitator Superfamily
K8U58_17885	COG2096	Adenosyltransferase
K8U58_17890	COG1120	ATPase activity
K8U58_17895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K8U58_17900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K8U58_17905	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_17910	COG3386	PFAM SMP-30 Gluconolaconase
K8U58_17915	COG2205	protein histidine kinase activity
K8U58_17920	COG0745	RESPONSE REGULATOR receiver
K8U58_17930	COG1191	sigma factor activity
K8U58_17940	COG2140	Oxalate decarboxylase
K8U58_17950	COG0577	efflux transmembrane transporter activity
K8U58_17955	COG1136	(ABC) transporter
K8U58_17960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K8U58_17965	COG1120	ATPase activity
K8U58_17970	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K8U58_17975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K8U58_17980	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K8U58_17985	COG0531	amino acid
K8U58_17995	COG1988	membrane-bound metal-dependent
K8U58_18000	COG1368	sulfuric ester hydrolase activity
K8U58_18005	COG1910	domain protein
K8U58_18010	COG0725	ABC transporter, periplasmic molybdate-binding protein
K8U58_18015	COG4149	molybdate abc transporter
K8U58_18020	COG0656	L-ascorbic acid biosynthetic process
K8U58_18030	COG0025	NhaP-type Na H and K H
K8U58_18035	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K8U58_18040	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
K8U58_18045	COG3973	AAA domain
K8U58_18050	COG2860	membrane
K8U58_18055	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
K8U58_18060	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K8U58_18065	COG2217	Heavy metal translocating P-type atpase
K8U58_18070	COG2217	Heavy metal translocating P-type atpase
K8U58_18075	COG2608	mercury ion transmembrane transporter activity
K8U58_18080	COG1937	Protein conserved in bacteria
K8U58_18085	COG0673	inositol 2-dehydrogenase activity
K8U58_18090	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
K8U58_18095	COG1289	transmembrane transporter activity
K8U58_18105	COG2076	Multidrug Resistance protein
K8U58_18110	COG1309	transcriptional regulator
K8U58_18115	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_18125	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
K8U58_18130	COG0557	exoribonuclease II activity
K8U58_18135	COG1647	Serine aminopeptidase, S33
K8U58_18140	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K8U58_18145	COG0596	Alpha beta hydrolase
K8U58_18150	COG1476	TRANSCRIPTIONal
K8U58_18155	COG1396	sequence-specific DNA binding
K8U58_18160	COG1396	sequence-specific DNA binding
K8U58_18165	COG1733	regulation of RNA biosynthetic process
K8U58_18170	COG0840	transmembrane signaling receptor activity
K8U58_18175	COG1174	glycine betaine transport
K8U58_18180	COG1732	Glycine betaine
K8U58_18185	COG1174	glycine betaine transport
K8U58_18190	COG1125	glycine betaine transport
K8U58_18190	COG0517	IMP dehydrogenase activity
K8U58_18195	COG1510	regulation of RNA biosynthetic process
K8U58_18215	COG5658	integral membrane protein
K8U58_18220	COG0640	Transcriptional regulator
K8U58_18225	COG1174	glycine betaine transport
K8U58_18230	COG1732	Glycine betaine
K8U58_18235	COG1174	glycine betaine transport
K8U58_18240	COG0517	IMP dehydrogenase activity
K8U58_18240	COG1125	glycine betaine transport
K8U58_18245	COG1510	regulation of RNA biosynthetic process
K8U58_18250	COG2095	MarC family integral membrane protein
K8U58_18260	COG3064	Membrane
K8U58_18265	COG4640	response to antibiotic
K8U58_18270	COG0456	acetyltransferase
K8U58_18275	COG0148	phosphopyruvate hydratase activity
K8U58_18280	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
K8U58_18285	COG0149	triose-phosphate isomerase activity
K8U58_18290	COG0126	phosphoglycerate kinase activity
K8U58_18295	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K8U58_18300	COG2390	Transcriptional regulator
K8U58_18305	COG2814	Major facilitator Superfamily
K8U58_18310	COG1609	Transcriptional regulator
K8U58_18315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K8U58_18320	COG0583	DNA-binding transcription factor activity
K8U58_18325	COG0697	spore germination
K8U58_18330	COG1113	amino acid transport
K8U58_18335	COG3858	chitin binding
K8U58_18340	COG1556	Lactate utilization protein
K8U58_18345	COG1139	Iron-sulfur cluster binding protein
K8U58_18350	COG0247	lactate metabolic process
K8U58_18355	COG2197	response regulator
K8U58_18360	COG4585	Histidine kinase
K8U58_18365	COG0842	Transport permease protein
K8U58_18370	COG1131	(ABC) transporter
K8U58_18375	COG0596	Alpha beta hydrolase
K8U58_18380	COG2208	phosphoserine phosphatase activity
K8U58_18385	COG3867	Arabinogalactan endo-beta-1,4-galactanase
K8U58_18390	COG1874	Beta-galactosidase
K8U58_18395	COG3833	ABC-type maltose transport systems, permease component
K8U58_18400	COG1175	transmembrane transport
K8U58_18405	COG2182	Extracellular solute-binding protein
K8U58_18410	COG1609	Transcriptional regulator
K8U58_18415	COG2186	Transcriptional regulator
K8U58_18420	COG1620	l-lactate permease
K8U58_18425	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
K8U58_18435	COG5039	Polysaccharide pyruvyl transferase
K8U58_18440	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K8U58_18445	COG0110	maltose O-acetyltransferase activity
K8U58_18450	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K8U58_18455	COG2244	polysaccharide biosynthetic process
K8U58_18460	COG1216	Glycosyl transferase, family 2
K8U58_18465	COG5039	Polysaccharide pyruvyl transferase
K8U58_18470	COG1216	Glycosyl transferase, family 2
K8U58_18480	COG0438	transferase activity, transferring glycosyl groups
K8U58_18485	COG1215	transferase activity, transferring glycosyl groups
K8U58_18490	COG0438	transferase activity, transferring glycosyl groups
K8U58_18495	COG1086	Polysaccharide biosynthesis protein
K8U58_18500	COG0489	protein tyrosine kinase activity
K8U58_18505	COG3944	biosynthesis protein
K8U58_18510	COG1396	sequence-specific DNA binding
K8U58_18515	COG2272	Belongs to the type-B carboxylesterase lipase family
K8U58_18525	COG3479	Phenolic acid decarboxylase
K8U58_18535	COG1794	racemase activity, acting on amino acids and derivatives
K8U58_18540	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K8U58_18545	COG1621	beta-fructofuranosidase activity
K8U58_18550	COG1621	beta-fructofuranosidase activity
K8U58_18555	COG0531	amino acid
K8U58_18560	COG1309	transcriptional regulator
K8U58_18565	COG2076	Multidrug Resistance protein
K8U58_18570	COG2076	Multidrug Resistance protein
K8U58_18580	COG0277	FAD linked oxidase domain protein
K8U58_18585	COG3621	Patatin-like phospholipase
K8U58_18595	COG0740	serine-type endopeptidase activity
K8U58_18600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K8U58_18605	COG0366	Alpha amylase catalytic
K8U58_18610	COG1554	hydrolase, family 65, central catalytic
K8U58_18615	COG5521	maltodextrose utilization protein MalA
K8U58_18620	COG3833	ABC-type maltose transport systems, permease component
K8U58_18625	COG1175	transmembrane transport
K8U58_18630	COG2182	Extracellular solute-binding protein
K8U58_18635	COG0366	Alpha amylase catalytic
K8U58_18640	COG1609	Transcriptional regulator
K8U58_18645	COG1611	Belongs to the LOG family
K8U58_18650	COG1694	Mazg nucleotide pyrophosphohydrolase
K8U58_18655	COG0659	secondary active sulfate transmembrane transporter activity
K8U58_18660	COG0288	reversible hydration of carbon dioxide
K8U58_18665	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K8U58_18670	COG0577	efflux transmembrane transporter activity
K8U58_18675	COG1136	(ABC) transporter
K8U58_18680	COG5002	protein histidine kinase activity
K8U58_18685	COG0745	RESPONSE REGULATOR receiver
K8U58_18695	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K8U58_18700	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8U58_18705	COG1481	regulation of sporulation
K8U58_18710	COG0391	Required for morphogenesis under gluconeogenic growth conditions
K8U58_18715	COG1660	Displays ATPase and GTPase activities
K8U58_18720	COG1051	belongs to the nudix hydrolase family
K8U58_18725	COG0492	ferredoxin-NADP+ reductase activity
K8U58_18730	COG3883	PFAM NLP P60 protein
K8U58_18730	COG0791	NLP P60 protein
K8U58_18735	COG0457	Tetratricopeptide repeat
K8U58_18740	COG1132	(ABC) transporter
K8U58_18760	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K8U58_18760	COG0140	phosphoribosyl-ATP diphosphatase activity
K8U58_18765	COG0107	imidazoleglycerol-phosphate synthase activity
K8U58_18770	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
K8U58_18775	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
K8U58_18780	COG0131	Imidazoleglycerol-phosphate dehydratase
K8U58_18785	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
K8U58_18790	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
K8U58_18795	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
K8U58_18800	COG4990	cell redox homeostasis
K8U58_18805	COG5297	Belongs to the glycosyl hydrolase family 6
K8U58_18810	COG0110	maltose O-acetyltransferase activity
K8U58_18815	COG0546	phosphoglycolate phosphatase activity
K8U58_18820	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
K8U58_18825	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K8U58_18830	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
K8U58_18835	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K8U58_18840	COG0363	glucosamine-6-phosphate deaminase activity
K8U58_18845	COG2188	Transcriptional regulator
K8U58_18850	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K8U58_18855	COG1846	Transcriptional regulator
K8U58_18860	COG2124	cytochrome p450
K8U58_18870	COG1846	Transcriptional regulator
K8U58_18875	COG2814	Major facilitator Superfamily
K8U58_18880	COG1950	PFAM Membrane protein of
K8U58_18885	COG1983	PspC domain protein
K8U58_18890	COG3595	metallopeptidase activity
K8U58_18910	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K8U58_18915	COG0556	nucleotide-excision repair
K8U58_18920	COG4897	Protein conserved in bacteria
K8U58_18925	COG3848	Pyruvate phosphate dikinase
K8U58_18925	COG0574	Belongs to the PEP-utilizing enzyme family
K8U58_18930	COG1309	transcriptional regulator
K8U58_18935	COG2814	Major facilitator Superfamily
K8U58_18940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K8U58_18950	COG3409	Peptidoglycan-binding domain 1 protein
K8U58_18950	COG0793	Belongs to the peptidase S41A family
K8U58_18955	COG2177	Part of the ABC transporter FtsEX involved in
K8U58_18960	COG2884	Cell division ATP-binding protein ftsE
K8U58_18965	COG2010	Cytochrome c
K8U58_18970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K8U58_18980	COG0653	protein targeting
K8U58_18985	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K8U58_19000	COG1516	flagellar protein fliS
K8U58_19005	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K8U58_19010	COG1334	flagellar protein FlaG
K8U58_19015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K8U58_19020	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
K8U58_19025	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
K8U58_19035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K8U58_19040	COG4786	Flagellar basal body rod
K8U58_19040	COG1256	bacterial-type flagellum assembly
K8U58_19045	COG3418	PFAM FlgN family protein
K8U58_19050	COG2747	anti-sigma28 factor FlgM
K8U58_19060	COG1040	competence protein
K8U58_19070	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
K8U58_19075	COG1307	EDD domain protein, DegV family
K8U58_19080	COG2197	response regulator
K8U58_19085	COG4585	Histidine kinase
K8U58_19090	COG1739	Uncharacterized protein family UPF0029
K8U58_19095	COG1316	TRANSCRIPTIONal
K8U58_19100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K8U58_19105	COG0438	transferase activity, transferring glycosyl groups
K8U58_19110	COG1215	transferase activity, transferring glycosyl groups
K8U58_19115	COG3206	protein involved in exopolysaccharide biosynthesis
K8U58_19120	COG3307	-O-antigen
K8U58_19125	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K8U58_19130	COG0297	glycogen (starch) synthase activity
K8U58_19130	COG0438	transferase activity, transferring glycosyl groups
K8U58_19135	COG2244	polysaccharide biosynthetic process
K8U58_19145	COG0860	N-Acetylmuramoyl-L-alanine amidase
K8U58_19145	COG2247	cell wall binding repeat
K8U58_19150	COG2247	cell wall binding repeat
K8U58_19150	COG2385	sporulation resulting in formation of a cellular spore
K8U58_19160	COG1316	TRANSCRIPTIONal
K8U58_19165	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
K8U58_19170	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K8U58_19180	COG1215	transferase activity, transferring glycosyl groups
K8U58_19180	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K8U58_19185	COG0463	Glycosyl transferase, family 2
K8U58_19195	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K8U58_19205	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K8U58_19210	COG1134	teichoic acid transport
K8U58_19215	COG1682	transport, permease protein
K8U58_19220	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K8U58_19225	COG0438	transferase activity, transferring glycosyl groups
K8U58_19230	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K8U58_19235	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
K8U58_19240	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K8U58_19250	COG4193	domain, Protein
K8U58_19255	COG1482	cell wall glycoprotein biosynthetic process
K8U58_19260	COG0697	spore germination
K8U58_19265	COG0814	amino acid
K8U58_19275	COG2814	Major facilitator Superfamily
K8U58_19280	COG1316	TRANSCRIPTIONal
K8U58_19285	COG0561	phosphatase activity
K8U58_19290	COG0791	NLP P60 protein
K8U58_19300	COG2843	Capsule synthesis protein
K8U58_19310	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
K8U58_19315	COG1609	Transcriptional regulator
K8U58_19320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K8U58_19325	COG1869	D-ribose catabolic process
K8U58_19330	COG1129	ABC transporter
K8U58_19335	COG1172	Belongs to the binding-protein-dependent transport system permease family
K8U58_19340	COG1879	ABC-type sugar transport system periplasmic component
K8U58_19345	COG3103	Sh3 type 3 domain protein
K8U58_19355	COG2249	NAD(P)H dehydrogenase (quinone) activity
K8U58_19360	COG3527	Alpha-acetolactate decarboxylase
K8U58_19365	COG0028	Belongs to the TPP enzyme family
K8U58_19370	COG0583	DNA-binding transcription factor activity
K8U58_19375	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K8U58_19390	COG5337	Spore coat protein CotH
K8U58_19400	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K8U58_19410	COG0405	Gamma-glutamyltransferase
K8U58_19415	COG1522	sequence-specific DNA binding
K8U58_19420	COG2059	Chromate
K8U58_19425	COG2059	Chromate
K8U58_19435	COG0655	NAD(P)H dehydrogenase (quinone) activity
K8U58_19440	COG0583	DNA-binding transcription factor activity
K8U58_19445	COG1515	deoxyribonuclease V activity
K8U58_19450	COG2849	repeat protein
K8U58_19455	COG5444	nuclease activity
K8U58_19475	COG3878	Protein conserved in bacteria
K8U58_19480	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K8U58_19485	COG4464	protein tyrosine phosphatase activity
K8U58_19490	COG0489	protein tyrosine kinase activity
K8U58_19495	COG3944	biosynthesis protein
K8U58_19505	COG4715	Zinc finger, swim domain protein
K8U58_19510	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K8U58_19515	COG0561	phosphatase activity
K8U58_19520	COG1349	DNA-binding transcription factor activity
K8U58_19525	COG0629	single-stranded DNA binding
K8U58_19550	COG2972	Histidine kinase
K8U58_19550	COG0745	RESPONSE REGULATOR receiver
K8U58_19555	COG1970	mechanosensitive ion channel activity
K8U58_19560	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K8U58_19565	COG0457	Tetratricopeptide repeat
K8U58_19570	COG4786	Flagellar basal body rod
K8U58_19575	COG4786	Flagellar basal body rod
K8U58_19580	COG1077	Cell shape determining protein MreB Mrl
K8U58_19585	COG1609	Transcriptional regulator
K8U58_19595	COG1846	Transcriptional regulator
K8U58_19600	COG2814	Major facilitator Superfamily
K8U58_19605	COG3420	alginic acid biosynthetic process
K8U58_19610	COG1953	Uracil, thiamine, allantoin
K8U58_19615	COG0477	Major facilitator Superfamily
K8U58_19620	COG1335	isochorismatase
K8U58_19630	COG0004	ammonium transporteR
K8U58_19635	COG0347	Belongs to the P(II) protein family
K8U58_19640	COG0671	phosphoesterase, PA-phosphatase related
K8U58_19650	COG0739	heme binding
K8U58_19655	COG1247	-acetyltransferase
K8U58_19675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K8U58_19680	COG0789	Transcriptional regulator
K8U58_19690	COG2910	NAD(P)H-binding
K8U58_19695	COG1959	2 iron, 2 sulfur cluster binding
K8U58_19700	COG0804	urea catabolic process
K8U58_19705	COG0832	Belongs to the urease beta subunit family
K8U58_19710	COG0831	urea catabolic process
K8U58_19725	COG3237	CsbD-like
K8U58_19730	COG1994	Peptidase M50
K8U58_19735	COG0457	Tetratricopeptide repeat
K8U58_19740	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K8U58_19745	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K8U58_19755	COG2304	oxidoreductase activity
K8U58_19765	COG2304	oxidoreductase activity
K8U58_19770	COG2385	sporulation resulting in formation of a cellular spore
K8U58_19775	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K8U58_19785	COG4836	Membrane
K8U58_19795	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K8U58_19800	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K8U58_19805	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K8U58_19810	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K8U58_19815	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K8U58_19820	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
K8U58_19830	COG0356	it plays a direct role in the translocation of protons across the membrane
K8U58_19840	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K8U58_19845	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
K8U58_19850	COG4475	Protein of unknown function (DUF436)
K8U58_19855	COG0698	ribose 5-phosphate isomerase
K8U58_19860	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K8U58_19865	COG1971	Probably functions as a manganese efflux pump
K8U58_19870	COG0009	L-threonylcarbamoyladenylate synthase
K8U58_19875	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K8U58_19895	COG2890	protein-(glutamine-N5) methyltransferase activity
K8U58_19900	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K8U58_19905	COG0346	lactoylglutathione lyase activity
K8U58_19910	COG0789	Transcriptional regulator
K8U58_19915	COG0679	Auxin Efflux Carrier
K8U58_19920	COG0281	malic enzyme
K8U58_19925	COG1435	thymidine kinase activity
K8U58_19935	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K8U58_19945	COG1494	fructose-1,6-bisphosphatase
K8U58_19950	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K8U58_19955	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K8U58_19960	COG0191	fructose-bisphosphate aldolase activity
K8U58_19965	COG2204	response regulator
K8U58_19970	COG4821	SIS domain
K8U58_19975	COG0504	CTP synthase activity
K8U58_19980	COG3343	RNA polymerase activity
K8U58_19985	COG1960	acyl-CoA dehydrogenase activity
K8U58_19990	COG0247	lactate metabolic process
K8U58_19990	COG2181	nitrate reductase activity
K8U58_19995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K8U58_20000	COG4294	response to UV
K8U58_20010	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K8U58_20015	COG1132	(ABC) transporter
K8U58_20020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K8U58_20025	COG2181	nitrate reductase activity
K8U58_20030	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
K8U58_20035	COG1140	nitrate reductase beta subunit
K8U58_20040	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
K8U58_20045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K8U58_20055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K8U58_20060	COG2223	nitrite transmembrane transporter activity
K8U58_20065	COG0018	arginyl-trna synthetase
K8U58_20070	COG4506	Protein conserved in bacteria
K8U58_20085	COG0535	radical SAM domain protein
K8U58_20095	COG1131	(ABC) transporter
K8U58_20100	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
K8U58_20105	COG0612	Peptidase, M16
K8U58_20110	COG0612	Peptidase, M16
K8U58_20120	COG3391	amine dehydrogenase activity
K8U58_20125	COG3391	amine dehydrogenase activity
K8U58_20130	COG0457	Tetratricopeptide repeat
K8U58_20140	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K8U58_20145	COG0010	Belongs to the arginase family
K8U58_20150	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K8U58_20155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K8U58_20165	COG1994	Peptidase M50
K8U58_20170	COG1942	4-Oxalocrotonate Tautomerase
K8U58_20175	COG1846	Transcriptional regulator
K8U58_20180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K8U58_20185	COG0477	Major facilitator Superfamily
K8U58_20190	COG1959	2 iron, 2 sulfur cluster binding
K8U58_20195	COG3465	dGTPase activity
K8U58_20200	COG1078	dGTPase activity
K8U58_20205	COG4844	belongs to the
K8U58_20215	COG0697	spore germination
K8U58_20220	COG0095	Lipoate-protein ligase
K8U58_20225	COG0583	DNA-binding transcription factor activity
K8U58_20230	COG0280	phosphate acetyltransferase
K8U58_20235	COG3253	May function as heme-dependent peroxidase
K8U58_20240	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_20245	COG0436	Aminotransferase
K8U58_20250	COG2814	Major facilitator Superfamily
K8U58_20255	COG0151	Belongs to the GarS family
K8U58_20260	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_20265	COG1917	Cupin 2, conserved barrel domain protein
K8U58_20270	COG0077	Prephenate dehydratase
K8U58_20275	COG2814	Major facilitator Superfamily
K8U58_20280	COG0833	amino acid
K8U58_20285	COG4187	Peptidase family M20/M25/M40
K8U58_20290	COG1012	belongs to the aldehyde dehydrogenase family
K8U58_20295	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K8U58_20305	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
K8U58_20310	COG1091	dTDP-4-dehydrorhamnose reductase activity
K8U58_20315	COG1088	dTDP-glucose 4,6-dehydratase activity
K8U58_20320	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
K8U58_20325	COG3980	spore coat polysaccharide biosynthesis protein
K8U58_20330	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
K8U58_20335	COG2089	acid synthase
K8U58_20340	COG0456	acetyltransferase
K8U58_20345	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K8U58_20350	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
K8U58_20355	COG0463	Glycosyl transferase, family 2
K8U58_20365	COG2363	Small membrane protein
K8U58_20370	COG2233	PERMEase
K8U58_20380	COG1012	belongs to the aldehyde dehydrogenase family
K8U58_20385	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K8U58_20390	COG1216	Glycosyl transferase, family 2
K8U58_20405	COG1695	Transcriptional regulator
K8U58_20410	COG0351	phosphomethylpyrimidine kinase
K8U58_20420	COG1621	beta-fructofuranosidase activity
K8U58_20425	COG1263	PTS System
K8U58_20425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K8U58_20430	COG2116	formate transmembrane transporter activity
K8U58_20435	COG3711	transcriptional antiterminator
K8U58_20445	COG1404	Belongs to the peptidase S8 family
K8U58_20450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K8U58_20455	COG0778	Nitroreductase
K8U58_20460	COG0772	Belongs to the SEDS family
K8U58_20470	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
K8U58_20475	COG1845	cytochrome c oxidase, subunit III
K8U58_20480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K8U58_20485	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
K8U58_20490	COG2261	transglycosylase associated protein
K8U58_20495	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
K8U58_20500	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
K8U58_20505	COG2246	polysaccharide biosynthetic process
K8U58_20510	COG1309	transcriptional regulator
K8U58_20520	COG3162	membrane
K8U58_20525	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K8U58_20530	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K8U58_20535	COG2837	iron assimilation
K8U58_20540	COG2822	iron ion transport
K8U58_20545	COG0672	)-iron permease
K8U58_20550	COG0352	thiamine-phosphate diphosphorylase activity
K8U58_20555	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
K8U58_20560	COG0583	DNA-binding transcription factor activity
K8U58_20565	COG1380	Effector of murein hydrolase LrgA
K8U58_20570	COG1346	cytolysis
K8U58_20575	COG2814	Major facilitator Superfamily
K8U58_20580	COG4895	conserved protein (DUF2196)
K8U58_20585	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
K8U58_20590	COG0346	lactoylglutathione lyase activity
K8U58_20600	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K8U58_20605	COG1404	Belongs to the peptidase S8 family
K8U58_20610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K8U58_20610	COG1263	PTS System
K8U58_20615	COG3711	transcriptional antiterminator
K8U58_20620	COG1442	glycosyl transferase family 8
K8U58_20625	COG5522	Integral membrane protein (intg_mem_TP0381)
K8U58_20630	COG1846	Transcriptional regulator
K8U58_20635	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
K8U58_20640	COG2234	aminopeptidase activity
K8U58_20645	COG2357	RelA SpoT domain protein
K8U58_20650	COG1575	Belongs to the MenA family. Type 1 subfamily
K8U58_20665	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K8U58_20670	COG1696	Membrane protein involved in D-alanine export
K8U58_20675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K8U58_20680	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
K8U58_20685	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
K8U58_20690	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
K8U58_20695	COG1486	melibiose metabolic process
K8U58_20700	COG1447	Phosphotransferase system cellobiose-specific component IIA
K8U58_20705	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K8U58_20710	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
K8U58_20715	COG3711	transcriptional antiterminator
K8U58_20715	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
K8U58_20725	COG2094	Belongs to the DNA glycosylase MPG family
K8U58_20730	COG0753	catalase activity
K8U58_20735	COG2814	Major facilitator Superfamily
K8U58_20740	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
K8U58_20745	COG1131	(ABC) transporter
K8U58_20765	COG1595	DNA-templated transcription, initiation
K8U58_20770	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K8U58_20775	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
K8U58_20780	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
K8U58_20785	COG4988	ABC transporter
K8U58_20790	COG1294	oxidase, subunit
K8U58_20795	COG1271	oxidase subunit
K8U58_20800	COG3493	citrate carrier protein
K8U58_20805	COG0501	Belongs to the peptidase M48B family
K8U58_20815	COG0726	polysaccharide deacetylase
K8U58_20820	COG3842	ATPase activity
K8U58_20825	COG2508	Transcriptional regulator
K8U58_20830	COG1012	belongs to the aldehyde dehydrogenase family
K8U58_20835	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
K8U58_20845	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K8U58_20850	COG1881	PFAM PEBP family protein
K8U58_20855	COG0583	DNA-binding transcription factor activity
K8U58_20865	COG4585	Histidine kinase
K8U58_20870	COG2197	response regulator
K8U58_20875	COG2195	Cleaves the N-terminal amino acid of tripeptides
K8U58_20885	COG4894	glucomannan catabolic process
K8U58_20890	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K8U58_20895	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K8U58_20900	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_20905	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K8U58_20910	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
K8U58_20915	COG2610	gluconate transmembrane transporter activity
K8U58_20920	COG0500	methyltransferase
K8U58_20925	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K8U58_20940	COG0753	catalase activity
K8U58_20940	COG0693	protein deglycase activity
K8U58_20945	COG2851	Citrate transporter
K8U58_20950	COG2273	Hydrolase Family 16
K8U58_20955	COG3711	transcriptional antiterminator
K8U58_20965	COG2270	Major facilitator Superfamily
K8U58_20970	COG0513	Belongs to the DEAD box helicase family
K8U58_20975	COG2755	lipolytic protein G-D-S-L family
K8U58_20975	COG3401	FG-GAP repeat protein
K8U58_21030	COG3209	COG3209 Rhs family protein
K8U58_21035	COG0697	spore germination
K8U58_21040	COG0589	response to stress
K8U58_21045	COG2723	6-phospho-beta-galactosidase activity
K8U58_21050	COG1263	PTS System
K8U58_21050	COG2190	(PTS) system
K8U58_21050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K8U58_21065	COG5444	nuclease activity
K8U58_21080	COG3507	Belongs to the glycosyl hydrolase 43 family
K8U58_21095	COG2986	histidine ammonia-lyase
K8U58_21100	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K8U58_21105	COG1228	amidohydrolase
K8U58_21110	COG0010	Belongs to the arginase family
K8U58_21115	COG0833	amino acid
K8U58_21120	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K8U58_21125	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K8U58_21130	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K8U58_21135	COG2390	Transcriptional regulator
K8U58_21145	COG3192	ethanolamine utilization protein
K8U58_21150	COG2079	MmgE PrpD family protein
K8U58_21155	COG1473	amidohydrolase
K8U58_21160	COG1126	abc transporter atp-binding protein
K8U58_21165	COG0765	amino acid transport
K8U58_21170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K8U58_21175	COG0456	acetyltransferase
K8U58_21180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K8U58_21190	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
K8U58_21195	COG0561	phosphatase activity
K8U58_21225	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K8U58_21230	COG5294	Protein conserved in bacteria
K8U58_21235	COG0577	efflux transmembrane transporter activity
K8U58_21240	COG1136	(ABC) transporter
K8U58_21245	COG2205	protein histidine kinase activity
K8U58_21250	COG0745	RESPONSE REGULATOR receiver
K8U58_21255	COG0191	fructose-bisphosphate aldolase activity
K8U58_21260	COG1082	Xylose isomerase domain protein TIM barrel
K8U58_21265	COG1082	Xylose isomerase domain protein TIM barrel
K8U58_21270	COG0673	inositol 2-dehydrogenase activity
K8U58_21275	COG2814	Major facilitator Superfamily
K8U58_21280	COG1082	Xylose isomerase domain protein TIM barrel
K8U58_21285	COG3962	Belongs to the TPP enzyme family
K8U58_21290	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K8U58_21295	COG3718	enzyme involved in inositol metabolism
K8U58_21300	COG1012	belongs to the aldehyde dehydrogenase family
K8U58_21305	COG1349	DNA-binding transcription factor activity
K8U58_21310	COG0667	Aldo Keto reductase
K8U58_21325	COG2814	Major facilitator Superfamily
K8U58_21330	COG0326	Molecular chaperone. Has ATPase activity
K8U58_21340	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_21345	COG1309	transcriptional regulator
K8U58_21350	COG1012	belongs to the aldehyde dehydrogenase family
K8U58_21355	COG0456	acetyltransferase
K8U58_21360	COG2850	peptidyl-arginine hydroxylation
K8U58_21365	COG2226	methyltransferase
K8U58_21380	COG0367	asparagine synthase
K8U58_21385	COG2814	Major facilitator Superfamily
K8U58_21390	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K8U58_21400	COG1714	RDD family
K8U58_21405	COG2311	Membrane
K8U58_21410	COG1917	Cupin 2, conserved barrel domain protein
K8U58_21415	COG1309	transcriptional regulator
K8U58_21420	COG1028	Short-chain dehydrogenase reductase Sdr
K8U58_21425	COG1846	Transcriptional regulator
K8U58_21430	COG1380	Effector of murein hydrolase LrgA
K8U58_21435	COG1346	cytolysis
K8U58_21440	COG5039	Polysaccharide pyruvyl transferase
K8U58_21445	COG1929	Belongs to the glycerate kinase type-1 family
K8U58_21450	COG1802	Transcriptional regulator
K8U58_21455	COG1070	Carbohydrate kinase
K8U58_21460	COG2610	gluconate transmembrane transporter activity
K8U58_21465	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K8U58_21470	COG0450	alkyl hydroperoxide reductase
K8U58_21475	COG3634	alkyl hydroperoxide reductase activity
K8U58_21480	COG2723	6-phospho-beta-galactosidase activity
K8U58_21490	COG2188	Transcriptional regulator
K8U58_21505	COG1131	(ABC) transporter
K8U58_21510	COG1994	Peptidase M50
K8U58_21515	COG0535	radical SAM domain protein
K8U58_21525	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
K8U58_21530	COG5293	efflux transmembrane transporter activity
K8U58_21540	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K8U58_21545	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K8U58_21560	COG1063	alcohol dehydrogenase
K8U58_21580	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
K8U58_21585	COG0456	acetyltransferase
K8U58_21590	COG0457	Tetratricopeptide repeat
K8U58_21600	COG0010	Belongs to the arginase family
K8U58_21605	COG0833	amino acid
K8U58_21610	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K8U58_21615	COG3829	transcription factor binding
K8U58_21630	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K8U58_21635	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K8U58_21640	COG4853	Protein conserved in bacteria
K8U58_21645	COG4863	YycH protein
K8U58_21650	COG5002	protein histidine kinase activity
K8U58_21655	COG0745	RESPONSE REGULATOR receiver
K8U58_21685	COG0346	lactoylglutathione lyase activity
K8U58_21690	COG0305	Participates in initiation and elongation during chromosome replication
K8U58_21705	COG3093	addiction module antidote protein HigA
K8U58_21710	COG2807	transmembrane transport
K8U58_21715	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K8U58_21720	COG0359	binds to the 23S rRNA
K8U58_21725	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
K8U58_21730	COG4241	membrane
K8U58_21740	COG5577	PFAM Coat F domain
K8U58_21745	COG1733	regulation of RNA biosynthetic process
K8U58_21750	COG1227	inorganic diphosphatase activity
K8U58_21765	COG2271	Major facilitator Superfamily
K8U58_21800	COG1131	(ABC) transporter
K8U58_21815	COG4319	ketosteroid isomerase
K8U58_21820	COG1357	PFAM Pentapeptide repeats (8 copies)
K8U58_21825	COG2814	Major facilitator Superfamily
K8U58_21830	COG0583	DNA-binding transcription factor activity
K8U58_21835	COG2153	protein acetylation
K8U58_21845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K8U58_21850	COG1846	Transcriptional regulator
K8U58_21855	COG2153	protein acetylation
K8U58_21860	COG2364	Membrane
K8U58_21865	COG0456	acetyltransferase
K8U58_21870	COG2315	Protein conserved in bacteria
K8U58_21875	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K8U58_21885	COG2814	Major facilitator Superfamily
K8U58_21895	COG1331	Highly conserved protein containing a thioredoxin domain
K8U58_21900	COG0789	Transcriptional regulator
K8U58_21905	COG0697	spore germination
K8U58_21910	COG1331	Highly conserved protein containing a thioredoxin domain
K8U58_21915	COG1266	CAAX protease self-immunity
K8U58_21920	COG2814	Major facilitator Superfamily
K8U58_21920	COG0477	Major facilitator Superfamily
K8U58_21925	COG0110	maltose O-acetyltransferase activity
K8U58_21930	COG0346	lactoylglutathione lyase activity
K8U58_21935	COG1609	Transcriptional regulator
K8U58_21940	COG0708	Exodeoxyribonuclease III
K8U58_21945	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
K8U58_21950	COG0629	single-stranded DNA binding
K8U58_21955	COG0360	Binds together with S18 to 16S ribosomal RNA
K8U58_21960	COG0012	GTP binding
K8U58_21965	COG0243	molybdopterin cofactor binding
K8U58_21970	COG4481	Protein conserved in bacteria
K8U58_21975	COG3949	Membrane
K8U58_21985	COG1475	DNA binding
K8U58_21990	COG1192	Involved in chromosome partitioning
K8U58_22000	COG1475	DNA binding
K8U58_22005	COG0357	Ribosomal RNA small subunit methyltransferase G
K8U58_22010	COG0445	tRNA wobble uridine modification
K8U58_22015	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
K8U58_22020	COG1847	R3H domain protein
K8U58_22025	COG0706	membrane insertase activity
K8U58_22030	COG0594	ribonuclease P activity
K8U58_22135	COG0457	Tetratricopeptide repeat
K8U58_22155	COG3584	3D domain protein
K8U58_22155	COG1388	LysM domain
K8U58_22165	COG0582	viral genome integration into host DNA
K8U58_22235	COG2887	Belongs to the helicase family. UvrD subfamily
K8U58_22240	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K8U58_22245	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K8U58_22250	COG0716	FMN binding
K8U58_22290	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K8U58_22330	COG0328	RNA-DNA hybrid ribonuclease activity
K8U58_22350	COG0587	DNA-directed DNA polymerase activity
K8U58_22370	COG0194	GDP metabolic process
K8U58_22420	COG0187	DNA topoisomerase II activity
K8U58_22425	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
K8U58_22490	COG5444	nuclease activity
K8U58_22545	COG3953	SLT domain
K8U58_22545	COG5280	Phage tail tape measure protein TP901