locus-tag class description GSY53_00030 ENOG4108SWU Histidine kinase GSY53_00035 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GSY53_00040 ENOG4105DHF Membrane GSY53_00050 ENOG4108UYN gCN5-related N-acetyltransferase GSY53_00055 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GSY53_00060 ENOG41068VA GSY53_00065 ENOG41087NI Sulfite exporter TauE/SafE GSY53_00070 ENOG4105VFE sira family GSY53_00075 ENOG4107TPS domain protein GSY53_00085 ENOG4105VFE sira family GSY53_00095 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase GSY53_00100 ENOG4105XTG Pfam:DUF156 GSY53_00105 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein GSY53_00115 ENOG41090E6 transcriptional regulator MERR family GSY53_00130 ENOG4105C37 (CBS) domain GSY53_00145 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family GSY53_00150 ENOG4105H3G oxidoreductase GSY53_00155 ENOG4105PGM cation diffusion facilitator family transporter GSY53_00160 ENOG41090U3 tautomerase GSY53_00180 ENOG4105KMT branched-chain amino acid GSY53_00185 ENOG4108UMN azlc family GSY53_00190 ENOG4108ZRZ Transcriptional regulator (AsnC family) GSY53_00195 ENOG41067XF inhibitor GSY53_00210 ENOG41064BW Protein of unknown function (DUF2568) GSY53_00225 ENOG41075D4 Aminoglycoside 6-adenylyltransferase GSY53_00230 ENOG4105EA8 2-Nitropropane dioxygenase GSY53_00235 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GSY53_00255 ENOG4108MEK Metal-binding protein YodA GSY53_00260 ENOG410904A RNA polymerase GSY53_00265 ENOG4105CPC Aldo Keto reductase GSY53_00275 ENOG4108KAM Transcriptional regulator GSY53_00280 ENOG4105C7F AcnD-accessory protein PrpF GSY53_00285 ENOG41083Q9 chitosanase GSY53_00290 ENOG4105X5K response regulator receiver protein GSY53_00295 ENOG4108VQT Alpha beta hydrolase fold protein GSY53_00300 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein GSY53_00305 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein GSY53_00315 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase GSY53_00325 ENOG4105PGS Spore coat protein GSY53_00330 ENOG4105E2A Dehydrogenase GSY53_00345 ENOG4105VUF Transcriptional regulator GSY53_00355 ENOG4105DQ4 alcohol dehydrogenase GSY53_00360 ENOG4108Z0Z intracellular protease Pfpi family GSY53_00365 ENOG4108HKT sucrose-6-phosphate hydrolase GSY53_00370 ENOG4105F3R pts system mannose fructose sorbose family iid GSY53_00375 ENOG4105ETZ PTS System GSY53_00380 ENOG4108IQ3 PTS system GSY53_00385 ENOG4105YHU PTS system GSY53_00390 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family GSY53_00400 ENOG4105C85 amino acid GSY53_00405 ENOG4105N14 lysine exporter protein LysE YggA GSY53_00410 ENOG4108NGU Transcriptional regulator GSY53_00415 ENOG4105JVQ RNA Polymerase GSY53_00420 ENOG4108P49 AntiSigma factor GSY53_00425 ENOG4105EXC Acyl-transferase GSY53_00430 ENOG4105WDR GSY53_00435 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GSY53_00440 ENOG41082JN Transcriptional regulator GSY53_00460 ENOG4105TMB Formate nitrite transporter GSY53_00465 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) GSY53_00470 ENOG4108JB9 formate dehydrogenase GSY53_00485 ENOG4105C28 cystathionine GSY53_00500 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) GSY53_00515 ENOG4107XRG penicillin-binding protein GSY53_00520 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) GSY53_00525 ENOG4105DBI uridine monophosphokinase GSY53_00530 ENOG4105CFP Peptidase U32 GSY53_00535 ENOG4105XYU peptidase (U32 family) GSY53_00540 ENOG4108VQJ O-methyltransferase GSY53_00545 ENOG4105HHA aminodeoxychorismate lyase GSY53_00550 ENOG4105VPH UPF0473 protein GSY53_00555 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) GSY53_00560 ENOG4105VBH UPF0297 protein GSY53_00565 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) GSY53_00570 ENOG4105C02 permease GSY53_00575 ENOG4105CDA abc transporter atp-binding protein GSY53_00580 ENOG4105CT1 (ABC) transporter GSY53_00585 ENOG4105EAD ABC transporter GSY53_00590 ENOG4105DRP amino acid AbC transporter GSY53_00600 ENOG41060CR GSY53_00610 ENOG4105C7H Helicase, RecD TraA family GSY53_00620 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) GSY53_00625 ENOG4105C3J Cysteine desulfurase GSY53_00635 ENOG4105D1H recombination factor protein RarA GSY53_00640 ENOG4105CUZ uba thif-type nad fad binding protein GSY53_00650 ENOG4105C9M aspartyl-trna synthetase GSY53_00655 ENOG4105CUT histidyl-tRNA synthetase GSY53_00665 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GSY53_00675 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) GSY53_00680 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) GSY53_00685 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) GSY53_00690 ENOG41067VP Protein of unknown function (DUF1049) GSY53_00695 ENOG4105NCW Trka-c domain protein GSY53_00700 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) GSY53_00710 ENOG4105CKP Polysaccharide Biosynthesis Protein GSY53_00715 ENOG4108QG2 Membrane GSY53_00720 ENOG4105NAP GSY53_00725 ENOG4105VIE preprotein translocase, subunit YajC GSY53_00730 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) GSY53_00735 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) GSY53_00740 ENOG41061AI Protein of unknown function (DUF2905) GSY53_00745 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) GSY53_00750 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) GSY53_00760 ENOG4105IE8 Alpha-ketoglutarate permease GSY53_00765 ENOG4105CK5 oxidoreductase GSY53_00790 ENOG4105BZG amino acid carrier protein GSY53_00795 ENOG4105CDY transcriptional regulatory protein GSY53_00805 ENOG4106678 morphogenetic protein associated with SpoVID GSY53_00810 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) GSY53_00815 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase GSY53_00820 ENOG4108IYU L-aspartate oxidase GSY53_00835 ENOG4105CQC Prephenate dehydratase GSY53_00840 ENOG41090I5 UPF0735 ACT domain-containing protein GSY53_00845 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control GSY53_00860 ENOG4105K46 50S ribosomal protein l27 GSY53_00865 ENOG4105X36 (ribosomal) protein GSY53_00870 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) GSY53_00885 ENOG4107QMS site-determining protein GSY53_00890 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) GSY53_00895 ENOG4105YHC Rod shape-determining protein MreD GSY53_00900 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) GSY53_00905 ENOG4105DFF Rod shape-determining protein mreb GSY53_00910 ENOG4105W5Q DNA repair protein (RadC GSY53_00915 ENOG4108Z03 MAF-like protein GSY53_00925 ENOG4106A3R peptidase GSY53_00930 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase GSY53_00935 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) GSY53_00945 ENOG4106AR7 Spore coat protein GSY53_00950 ENOG41068KH stage VI sporulation protein D GSY53_00955 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase GSY53_00960 ENOG4105D52 delta-aminolevulinic acid dehydratase GSY53_00970 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) GSY53_00980 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) GSY53_00990 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) GSY53_00995 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) GSY53_01000 ENOG4108IUQ atp-dependent protease GSY53_01005 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) GSY53_01010 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation GSY53_01020 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GSY53_01025 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) GSY53_01030 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GSY53_01035 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) GSY53_01040 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase GSY53_01045 ENOG4108ZP8 Acetolactate synthase small subunit GSY53_01050 ENOG4105C7K acetolactate synthase GSY53_01060 ENOG4105I4A GCN5-related N-acetyltransferase GSY53_01065 ENOG4107KM7 Heat induced stress protein YflT GSY53_01075 ENOG4105M59 Phosphodiesterase, mj0936 family GSY53_01080 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) GSY53_01085 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) GSY53_01090 ENOG4108XJQ germination protein GSY53_01095 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) GSY53_01100 ENOG41067TZ transcriptional regulator, MarR family GSY53_01105 ENOG4105PFC Transcriptional regulator GSY53_01115 ENOG4105E33 succinate dehydrogenase GSY53_01125 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit GSY53_01135 ENOG4105CFH Aspartokinase GSY53_01140 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) GSY53_01145 ENOG4105K63 Thioredoxin GSY53_01150 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) GSY53_01155 ENOG4105C10 Electron transfer flavoprotein GSY53_01160 ENOG4105BZJ Electron transfer flavoprotein GSY53_01165 ENOG41060WC Enoyl-CoA hydratase GSY53_01170 ENOG4107Z3H Transcriptional regulator, TetR family GSY53_01175 ENOG4105CEY Amp-dependent synthetase and ligase GSY53_01185 ENOG4105C98 muts2 protein GSY53_01190 ENOG4105DCG PHP domain protein GSY53_01205 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GSY53_01210 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) GSY53_01215 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) GSY53_01225 ENOG4108RWN rrna methyltransferase GSY53_01230 ENOG41067MF small acid-soluble spore protein GSY53_01240 ENOG4105CQB FAD linked oxidase domain protein GSY53_01245 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GSY53_01265 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) GSY53_01270 ENOG4105DRS transport system, permease GSY53_01285 ENOG4108MDK Dehydrogenase GSY53_01295 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase GSY53_01300 ENOG4105EF1 ribulokinase GSY53_01310 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase GSY53_01315 ENOG4105CN9 Peptidase m42 family protein GSY53_01325 ENOG410696E Membrane GSY53_01330 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) GSY53_01335 ENOG4105VJV 50s ribosomal protein L35 GSY53_01340 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) GSY53_01350 ENOG41067MG lrgb family GSY53_01360 ENOG4105DY9 regulatoR GSY53_01365 ENOG4108HRK Histidine kinase GSY53_01370 ENOG4105U0R haloacid dehalogenase-like hydrolase GSY53_01375 ENOG4105C22 threonyL-tRNA synthetase GSY53_01380 ENOG4108TDW sporulation protein YtxC GSY53_01400 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) GSY53_01405 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) GSY53_01410 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GSY53_01415 ENOG4105KVH Transcriptional regulator GSY53_01420 ENOG4105F27 Major Facilitator GSY53_01425 ENOG4105CV8 reductase GSY53_01430 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) GSY53_01440 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) GSY53_01445 ENOG4105C2M dna polymerase I GSY53_01450 ENOG4105BZU Histidine kinase GSY53_01455 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GSY53_01460 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GSY53_01465 ENOG4108HMX isocitrate dehydrogenase (NADP) GSY53_01470 ENOG4105BZN citrate synthase GSY53_01480 ENOG4108REF Sporulation integral membrane protein ytvi GSY53_01485 ENOG4105FS0 cytoplasmic membrane protein GSY53_01490 ENOG4105CA9 Pyruvate kinase GSY53_01495 ENOG4105CTQ phosphohexokinase GSY53_01505 ENOG4108IEY Carboxyl transferase domain GSY53_01510 ENOG4105C6K Malic enzyme GSY53_01515 ENOG4105C0B DNA polymerase III (alpha subunit) GSY53_01520 ENOG4105VV2 GSY53_01530 ENOG4106EVM GSY53_01535 ENOG4105SFS phosphoesterase RecJ domain protein GSY53_01550 ENOG410635A Membrane GSY53_01555 ENOG4105CH2 amidohydrolase GSY53_01575 ENOG4105DEN Luciferase family GSY53_01580 ENOG4105CDA abc transporter atp-binding protein GSY53_01605 ENOG4108XSB acetyltransferase, (GNAT) family GSY53_01610 ENOG4108KSA LysR family transcriptional regulator GSY53_01615 ENOG4105E8R UPF0173 metal-dependent hydrolase GSY53_01630 ENOG4105CH7 arginosuccinase GSY53_01635 ENOG4105CDH Citrulline--aspartate ligase GSY53_01640 ENOG4105EPU Molybdenum cofactor synthesis domain protein GSY53_01645 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) GSY53_01660 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) GSY53_01665 ENOG4105KBJ sporulation protein ytfj GSY53_01675 ENOG4105VK3 rdd domain containing protein GSY53_01680 ENOG4105D07 Signal peptide peptidase, SppA GSY53_01685 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GSY53_01690 ENOG4105EFZ amidohydrolase GSY53_01695 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) GSY53_01730 ENOG4105U5Y Transcriptional regulator GSY53_01740 ENOG4105BZU Histidine kinase GSY53_01750 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) GSY53_01755 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GSY53_01765 ENOG4105F1V Acetoin utilization protein GSY53_01770 ENOG4105W87 Cbs domain GSY53_01775 ENOG4105DGU Histone deacetylase GSY53_01780 ENOG4105ER2 Ompa motb domain protein GSY53_01785 ENOG4107R0U MotA TolQ exbB proton channel GSY53_01790 ENOG4105ETE Transcriptional regulator (LacI family GSY53_01795 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase GSY53_01815 ENOG4105DFU Cell wall formation (By similarity) GSY53_01825 ENOG4108VDD TRNA binding domain protein GSY53_01845 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ GSY53_01860 ENOG4105C6K Malic enzyme GSY53_01865 ENOG4105C8F Beta-lactamase domain protein GSY53_01870 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) GSY53_01880 ENOG4108V15 phosphotransferase enzyme family GSY53_01885 ENOG4108IUM Glycogen debranching enzyme GSY53_01900 ENOG4107F58 2'-5' rna ligase GSY53_01905 ENOG4105C6T cysteine synthase GSY53_01910 ENOG4107QSE Dipeptidase GSY53_01915 ENOG4105C7N Xanthine uracil vitamin C permease GSY53_01930 ENOG4105YW5 deoR family transcriptional regulator GSY53_01945 ENOG4105CBX hi0933 family GSY53_01950 ENOG4105C94 Transporter GSY53_01960 ENOG4105MU9 integral membrane protein GSY53_01965 ENOG4105DDC Oxidoreductase domain protein GSY53_01975 ENOG4105F5H Glycosyl Hydrolase Family 88 GSY53_01985 ENOG41075H3 AraC family transcriptional regulator GSY53_01995 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component GSY53_02005 ENOG4106A3M Cytochrome p-450 GSY53_02010 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) GSY53_02020 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GSY53_02025 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GSY53_02035 ENOG4105NTD Inherit from COG: Hydrolase GSY53_02050 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component GSY53_02055 ENOG4105I1K ABC transporter GSY53_02065 ENOG41085GJ domain protein GSY53_02070 ENOG4105C8T Leucyl-tRNA synthetase GSY53_02080 ENOG4105BZU Histidine kinase GSY53_02085 ENOG410605W Major Facilitator GSY53_02090 ENOG4106UBQ GSY53_02100 ENOG4105C19 ABC transporter GSY53_02105 ENOG4105EWM Histidine kinase GSY53_02115 ENOG4107R34 abc transporter permease protein GSY53_02120 ENOG4105C19 ABC transporter GSY53_02135 ENOG4105DVE abc transporter atp-binding protein GSY53_02140 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family GSY53_02155 ENOG4105N5T Radical SAM Protein GSY53_02170 ENOG4105E8V Alpha Beta Hydrolase Fold protein GSY53_02175 ENOG4108Z0R Transferase GSY53_02180 ENOG4105C85 amino acid GSY53_02185 ENOG4105CAQ asparagine synthetase GSY53_02190 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP GSY53_02195 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase GSY53_02210 ENOG4105D2X ABC transporter substrate-binding protein GSY53_02220 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component GSY53_02235 ENOG4108RMU ferritin dps family protein GSY53_02250 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) GSY53_02255 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) GSY53_02260 ENOG4108V2W Carbonate dehydratase GSY53_02285 ENOG4105CC5 ABC transporter GSY53_02290 ENOG4105CC5 ABC transporter GSY53_02295 ENOG4105DIK (ABC) transporter GSY53_02300 ENOG4105DSE periplasmic solute binding protein GSY53_02305 ENOG4105DTQ mandelate racemase muconate lactonizing GSY53_02310 ENOG4105CEY Amp-dependent synthetase and ligase GSY53_02315 ENOG4108IPT Naphthoate synthase GSY53_02320 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) GSY53_02325 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) GSY53_02330 ENOG4105E4F Isochorismate synthase GSY53_02350 ENOG4108IAJ Nad-dependent epimerase dehydratase GSY53_02355 ENOG4107SBE Glycosyl transferase (Group 1 GSY53_02370 ENOG4107SBE Glycosyl transferase (Group 1 GSY53_02375 ENOG4108KS4 Spore coat protein GSY53_02390 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) GSY53_02400 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) GSY53_02530 ENOG4105N67 Proton-coupled thiamine transporter YuaJ GSY53_02535 ENOG4105VRR gCN5-related N-acetyltransferase GSY53_02540 ENOG4105DZ6 Band 7 protein GSY53_02550 ENOG4106DF1 GSY53_02555 ENOG4108VNY MOSC domain protein GSY53_02560 ENOG4108JB8 alcohol dehydrogenase GSY53_02565 ENOG4105C26 Dehydrogenase GSY53_02570 ENOG4105TRT Transcriptional regulator GSY53_02585 ENOG4105CZN Potassium uptake protein GSY53_02590 ENOG4107I77 yiaA/B two helix domain GSY53_02595 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GSY53_02615 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) GSY53_02625 ENOG4105EE0 oxidoreductase GSY53_02630 ENOG4105DKG l-rhamnose isomerase GSY53_02635 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) GSY53_02640 ENOG4105DET Rhamnulokinase GSY53_02645 ENOG4105E98 transcriptional regulator DeoR family GSY53_02655 ENOG4105C8Q Methyl-accepting chemotaxis GSY53_02660 ENOG4105C8Q Methyl-accepting chemotaxis GSY53_02665 ENOG4105C8Q Methyl-accepting chemotaxis GSY53_02670 ENOG4105C8Q Methyl-accepting chemotaxis GSY53_02685 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme GSY53_02700 ENOG4105C37 (CBS) domain GSY53_02715 ENOG4107PBV potassium channel GSY53_02720 ENOG4107PBV potassium channel GSY53_02735 ENOG4107QYV phosphohexose isomerase GSY53_02745 ENOG4107QW4 alcohol dehydrogenase GSY53_02750 ENOG4105WG9 Conserved Protein GSY53_02760 ENOG4105CHM Aminotransferase GSY53_02765 ENOG4108ZB6 transcriptional regulator AsnC family GSY53_02770 ENOG4108MUZ hydrolase GSY53_02780 ENOG4105C87 Aminotransferase class I and II GSY53_02785 ENOG4108HGU Histidine kinase GSY53_02790 ENOG4105Y38 Kinase-associated protein B GSY53_02810 ENOG4105BZ4 penicillin-binding protein GSY53_02815 ENOG4105KIR Thiol-disulfide oxidoreductase dcc GSY53_02830 ENOG4108MRH transcriptional regulatory protein GSY53_02835 ENOG4105DIH basic membrane GSY53_02840 ENOG4108JQ9 ABC transporter GSY53_02845 ENOG4105UIB (ABC) transporter GSY53_02865 ENOG4105D65 subunit l GSY53_02870 ENOG4105HC0 Na H antiporter GSY53_02875 ENOG4108ZE9 Monovalent cation H antiporter subunit C GSY53_02880 ENOG4108JPZ Monovalent cation H antiporter subunit D GSY53_02885 ENOG4105SC1 monovalent cation H antiporter subunit E GSY53_02895 ENOG4105KJM monovalent cation h antiporter subunit g GSY53_02900 ENOG4105KA0 thioesterase Superfamily protein GSY53_02910 ENOG4105BZU Histidine kinase GSY53_02940 ENOG4105D58 Diguanylate phosphodiesterase GSY53_02945 ENOG4105DAP Nicotinate phosphoribosyltransferase GSY53_02970 ENOG4105C02 permease GSY53_02990 ENOG410904N short-chain dehydrogenase reductase GSY53_03025 ENOG4108K8K Transcriptional regulator GSY53_03030 ENOG4105DCF alanine dehydrogenase GSY53_03040 ENOG4105WQT MbtH domain protein GSY53_03045 ENOG4105CEY Amp-dependent synthetase and ligase GSY53_03050 ENOG4105WQI isochorismatase GSY53_03055 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase GSY53_03060 ENOG4105E4F Isochorismate synthase GSY53_03065 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase GSY53_03070 ENOG4105NIV Esterase GSY53_03090 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) GSY53_03100 ENOG41069ER domain protein GSY53_03115 ENOG4105CEP NADH dehydrogenase GSY53_03120 ENOG4105CAY ferredoxin--nadp reductase GSY53_03140 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 GSY53_03145 ENOG4108YX9 iron--sulfur cluster insertion protein erpA GSY53_03160 ENOG4105ZKE UPF0349 protein GSY53_03175 ENOG41083MR nifu domain-containing protein GSY53_03180 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein GSY53_03185 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) GSY53_03190 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) GSY53_03195 ENOG4105D6E homoserine dehydrogenase GSY53_03205 ENOG4108W5N phosphatidylglycerophosphatase a GSY53_03210 ENOG4105D4U had-superfamily hydrolase, subfamily iia GSY53_03220 ENOG4105MMD transcriptional regulator GSY53_03225 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) GSY53_03230 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) GSY53_03235 ENOG4105FAA peptidase M23 GSY53_03240 ENOG4108YTE sporulation protein YunB GSY53_03245 ENOG4105KZD Domain of unknown function (DUF1805) GSY53_03250 ENOG4107R8B 5'-nucleotidase GSY53_03260 ENOG4105I3N Conserved Protein GSY53_03270 ENOG4105CD3 dihydroorotase GSY53_03275 ENOG4105G9B Transcriptional regulator GSY53_03290 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) GSY53_03295 ENOG4105VT2 5-hydroxyisourate hydrolase GSY53_03305 ENOG4107YV9 domain protein GSY53_03310 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding GSY53_03325 ENOG4105XRQ Xanthine dehydrogenase accessory factor GSY53_03330 ENOG4105C5R Aminotransferase GSY53_03345 ENOG4108K8S endonuclease I GSY53_03350 ENOG4108IJ9 (ABC) transporter GSY53_03355 ENOG4105FDP GntR family transcriptional regulator GSY53_03360 ENOG4108KPW sugar kinase GSY53_03365 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component GSY53_03370 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component GSY53_03375 ENOG4105XN3 extracellular solute-binding protein family 1 GSY53_03380 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine GSY53_03385 ENOG4105PKS Excinuclease abc c subunit domain protein GSY53_03390 ENOG4107VFR oxidoreductase GSY53_03405 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase GSY53_03410 ENOG4105NPE arsR family transcriptional regulator GSY53_03415 ENOG4105DIW FeS assembly protein SUFB GSY53_03420 ENOG4108UNV SUF system FeS assembly protein, NifU family GSY53_03425 ENOG4105C9B Cysteine desulfurase GSY53_03430 ENOG4105JRK feS assembly protein SufD GSY53_03435 ENOG4105C3K feS assembly ATPase SufC GSY53_03450 ENOG4105D01 (LipO)protein GSY53_03455 ENOG4108UMI ABC transporter, permease GSY53_03460 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) GSY53_03485 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) GSY53_03490 ENOG41080E8 Transcriptional regulator, Spx MgsR family GSY53_03495 ENOG4105C1G acyl-Coa dehydrogenase GSY53_03500 ENOG4105CHU acetyl-coa acetyltransferase GSY53_03530 ENOG41067TZ transcriptional regulator, MarR family GSY53_03535 ENOG4105C0R drug resistance transporter emrb qaca subfamily GSY53_03540 ENOG4105MDS 4-oxalocrotonate tautomerase GSY53_03550 ENOG4105EGI Transcriptional regulator GSY53_03560 ENOG4105E0A ABC, transporter GSY53_03575 ENOG4105E1F short-chain dehydrogenase reductase GSY53_03580 ENOG4105HUF DNA protection during starvation protein GSY53_03585 ENOG4105C0H protease GSY53_03595 ENOG4105F3H Histidine kinase GSY53_03605 ENOG41067SE Tetr family transcriptional regulator GSY53_03610 ENOG4105C9Q fumarate hydratase class II GSY53_03635 ENOG4105WH1 Two component transcriptional regulator luxr family GSY53_03640 ENOG4105ENE Histidine kinase GSY53_03655 ENOG41087YS Phage shock protein A GSY53_03670 ENOG4108WBT adenosyltransferase GSY53_03675 ENOG4105E0A ABC, transporter GSY53_03680 ENOG4105EHG Permease protein GSY53_03685 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) GSY53_03690 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GSY53_03695 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein GSY53_03705 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GSY53_03715 ENOG4106DF4 Sigma-70, region 4 GSY53_03725 ENOG4105F0F Oxalate decarboxylase GSY53_03735 ENOG4107RBB ABC transporter, permease GSY53_03740 ENOG4105C19 ABC transporter GSY53_03745 ENOG4108WMK Efflux transporter RND family MFP subunit GSY53_03750 ENOG4105E0A ABC, transporter GSY53_03755 ENOG4105EHG Permease protein GSY53_03760 ENOG4105DQ5 transport system permease protein GSY53_03770 ENOG4105D5Q Arginine ornithine antiporter GSY53_03780 ENOG4107K5X Membrane-bound metal-dependent hydrolase GSY53_03785 ENOG4107QZ2 Sulfatase GSY53_03790 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family GSY53_03795 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein GSY53_03800 ENOG4105E0C molybdate abc transporter GSY53_03815 ENOG4105EEQ Na H antiporter GSY53_03820 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) GSY53_03825 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GSY53_03830 ENOG4105EEM helicase GSY53_03835 ENOG4105EN6 Membrane GSY53_03845 ENOG4107ZQN disulfide bond GSY53_03850 ENOG4105C59 p-type ATPase GSY53_03855 ENOG4105C59 p-type ATPase GSY53_03860 ENOG410681U heavy metal transport detoxification protein GSY53_03865 ENOG4105VPX protein, conserved in bacteria GSY53_03870 ENOG4105D9R oxidoreductase GSY53_03875 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GSY53_03880 ENOG4105ME7 Membrane GSY53_03885 ENOG4105RXJ GSY53_03890 ENOG4105KPY Small multidrug resistance protein GSY53_03895 ENOG4105KBX Transcriptional regulator, TetR family GSY53_03900 ENOG4105EWI Short-chain dehydrogenase reductase Sdr GSY53_03910 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) GSY53_03915 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) GSY53_03925 ENOG4105XZU Preprotein translocase, subunit SecG GSY53_03950 ENOG4105KVH Transcriptional regulator GSY53_03955 ENOG4105C8Q Methyl-accepting chemotaxis GSY53_03960 ENOG4105R40 Glycine betaine carnitine choline GSY53_03965 ENOG4108HQR Glycine betaine GSY53_03970 ENOG4105E90 ABC transporter GSY53_03975 ENOG4108IJ8 ABC transporter GSY53_03980 ENOG4107HG4 Transcriptional regulator GSY53_03990 ENOG4105H5S GSY53_04005 ENOG41082BM Transcriptional regulator, arsr family GSY53_04010 ENOG4105R40 Glycine betaine carnitine choline GSY53_04015 ENOG4108HQR Glycine betaine GSY53_04020 ENOG4105E90 ABC transporter GSY53_04025 ENOG4108IJ8 ABC transporter GSY53_04030 ENOG4107HG4 Transcriptional regulator GSY53_04035 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein GSY53_04040 ENOG4108QCI YvbH-like oligomerisation region GSY53_04050 ENOG4105T65 Membrane-associated protein GSY53_04055 ENOG4108W0I acetyltransferase GSY53_04060 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) GSY53_04065 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) GSY53_04070 ENOG4105CP7 Triose-phosphate isomerase GSY53_04075 ENOG4105BZA Phosphoglycerate kinase GSY53_04080 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase GSY53_04095 ENOG4105CMD Transcriptional regulator, GntR family GSY53_04100 ENOG4105DEN Luciferase family GSY53_04105 ENOG4105GZI Transcriptional regulator GSY53_04110 ENOG4107RT3 EamA-like transporter family GSY53_04120 ENOG4105VRS hydrolase family 18 GSY53_04125 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) GSY53_04130 ENOG4107QR9 Iron-sulfur cluster binding protein GSY53_04135 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) GSY53_04145 ENOG4105BZU Histidine kinase GSY53_04150 ENOG4105KCT ABC transporter GSY53_04155 ENOG4108M15 ABC transporter GSY53_04160 ENOG4107R6F Alpha Beta Hydrolase Fold protein GSY53_04165 ENOG4108MJI response regulator GSY53_04180 ENOG4105EG2 ABC transporter, permease GSY53_04190 ENOG4107FKK extracellular solute-binding protein family 1 GSY53_04200 ENOG4105JXH GntR family transcriptional regulator GSY53_04205 ENOG4105DAA L-lactate GSY53_04210 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GSY53_04220 ENOG4108ZPC Polysaccharide pyruvyl transferase GSY53_04225 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GSY53_04230 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family GSY53_04235 ENOG4105D3Q Sugar transferase GSY53_04245 ENOG4105K64 Glycosyl transferase, family 2 GSY53_04255 ENOG4107QRS glycosyltransferase group 2 family protein GSY53_04260 ENOG41068W6 Capsular polysaccharide biosynthesis protein GSY53_04265 ENOG4108KMV Glycosyl transferase (Group 1 GSY53_04270 ENOG4105K64 Glycosyl transferase, family 2 GSY53_04275 ENOG4108PQP glycosyl transferase group 1 GSY53_04285 ENOG4108QV3 biosynthesis protein GSY53_04290 ENOG4105HTX biosynthesis protein GSY53_04300 ENOG4105EBR Carboxylesterase GSY53_04310 ENOG4105PY6 Phenolic acid decarboxylase GSY53_04315 ENOG4105NI3 Protein of unknown function (DUF3237) GSY53_04325 ENOG4105FQP Beta-lactamase GSY53_04330 ENOG4105EDQ levansucrase EC 2.4.1.10 GSY53_04335 ENOG4108HKT sucrose-6-phosphate hydrolase GSY53_04340 ENOG4107QTZ amino acid GSY53_04365 ENOG4105DNP FAD linked oxidase domain protein GSY53_04370 ENOG4105IRW patatin-like phospholipase family protein GSY53_04380 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) GSY53_04385 ENOG4107URF beta-phospho-glucomutase GSY53_04390 ENOG4105CG3 alpha amylase, catalytic region GSY53_04405 ENOG4105EG2 ABC transporter, permease GSY53_04410 ENOG4105D56 permease protein GSY53_04415 ENOG4107FKK extracellular solute-binding protein family 1 GSY53_04420 ENOG4108IUK alpha amylase, catalytic GSY53_04425 ENOG4105FKQ transcriptional regulator GSY53_04430 ENOG4108URH decarboxylase GSY53_04435 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain GSY53_04440 ENOG4105CHH sulfate transporter GSY53_04445 ENOG4108V2W Carbonate dehydratase GSY53_04450 ENOG4105C5I Dehydrogenase GSY53_04460 ENOG4105C19 ABC transporter GSY53_04465 ENOG4105EWM Histidine kinase GSY53_04475 ENOG4107A6P GSY53_04480 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase GSY53_04485 ENOG4105KRI phosphocarrier protein (HPr GSY53_04490 ENOG4105CIE May be required for sporulation (By similarity) GSY53_04495 ENOG4105CHW UPF0052 protein GSY53_04500 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) GSY53_04505 ENOG4108Z4K mutator MutT protein GSY53_04510 ENOG4105C3M thioredoxin reductase GSY53_04525 ENOG4105BZ1 (ABC) transporter GSY53_04535 ENOG4106FGC GSY53_04545 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase GSY53_04550 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) GSY53_04555 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase GSY53_04560 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) GSY53_04565 ENOG4105ECC imidazole-glycerol-phosphate dehydratase GSY53_04570 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) GSY53_04575 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) GSY53_04580 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) GSY53_04590 ENOG4108E16 pectate lyase GSY53_04595 ENOG4108S4C acetyltransferase GSY53_04600 ENOG4107XGZ Hydrolase GSY53_04605 ENOG4105HKU nucleoside recognition domain-containing protein GSY53_04610 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) GSY53_04615 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) GSY53_04620 ENOG4105CE4 GlcNAc 6-P deacetylase GSY53_04625 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GSY53_04630 ENOG4105FDP GntR family transcriptional regulator GSY53_04635 ENOG41088CQ domain protein GSY53_04645 ENOG4106A3M Cytochrome p-450 GSY53_04650 ENOG410625E GSY53_04665 ENOG41086DT Membrane protein of unknown function GSY53_04670 ENOG41067S9 phage shock protein C, PspC GSY53_04675 ENOG4108PY7 GSY53_04695 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) GSY53_04700 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) GSY53_04715 ENOG4105MKU Transcriptional regulator GSY53_04735 ENOG4105CN1 protease GSY53_04740 ENOG4105CRP Part of the ABC transporter FtsEX involved in GSY53_04745 ENOG4105CAK Cell division ATP-binding protein ftsE GSY53_04770 ENOG4105MS2 ribosomal subunit Interface protein GSY53_04785 ENOG4105MQ3 flagellar protein FliS GSY53_04790 ENOG4107RT6 flagellar hook-associated GSY53_04795 ENOG41083S7 flagellar protein FlaG GSY53_04800 ENOG4105I03 Flagellin GSY53_04805 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) GSY53_04810 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) GSY53_04815 ENOG4105MKD GSY53_04820 ENOG4105DTJ flagellar hook-associated protein GSY53_04825 ENOG4105E1Q flagellar hook-associated protein GSY53_04840 ENOG4105RU3 GSY53_04845 ENOG41081UC Inherit from COG: Competence protein GSY53_04865 ENOG4105WH1 Two component transcriptional regulator luxr family GSY53_04870 ENOG4105BZU Histidine kinase GSY53_04875 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein GSY53_04880 ENOG4108KGH TRANSCRIPTIONal GSY53_04885 ENOG4105ESV Glycosyl transferase, family 4 GSY53_04890 ENOG4107EF8 Glycosyl transferase (Group 1 GSY53_04905 ENOG4105QZI O-Antigen Polymerase GSY53_04910 ENOG4105C6Y Udp-glucose 6-dehydrogenase GSY53_04915 ENOG4107RA4 Glycosyl transferase (Group 1 GSY53_04920 ENOG4105PSV Polysaccharide Biosynthesis Protein GSY53_04925 ENOG4105D3Q Sugar transferase GSY53_04930 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GSY53_04935 ENOG4105JFG SpoIID LytB domain protein GSY53_04950 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase GSY53_04955 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GSY53_04965 ENOG4107VDP teichoic acid biosynthesis GSY53_04970 ENOG41088M2 Glycosyl transferase family 2 GSY53_04980 ENOG4107SJB teichoic acid biosynthesis GSY53_04990 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GSY53_04995 ENOG4105EY8 ABC transporter GSY53_05005 ENOG4107SJB teichoic acid biosynthesis GSY53_05010 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) GSY53_05015 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase GSY53_05025 ENOG4107RZX Teichoic acid biosynthesis protein GSY53_05040 ENOG4105DG6 mannose-6-phosphate isomerase GSY53_05055 ENOG4108NHD germination protein GSY53_05060 ENOG4105C54 Major Facilitator superfamily GSY53_05065 ENOG4108KGH TRANSCRIPTIONal GSY53_05070 ENOG4105J7I hydrolase GSY53_05075 ENOG4105K4H Nlp p60 protein GSY53_05085 ENOG4105PNM synthesis protein GSY53_05095 ENOG4105N98 Capsule biosynthesis protein capB GSY53_05100 ENOG4105ETE Transcriptional regulator (LacI family GSY53_05105 ENOG4108RVA ribokinase GSY53_05110 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) GSY53_05115 ENOG4105C2J ABC transporter GSY53_05120 ENOG4105CNN ABC, transporter GSY53_05125 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator GSY53_05140 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GSY53_05145 ENOG4107FQX Alpha-acetolactate decarboxylase GSY53_05155 ENOG4107RSM transcriptional regulator GSY53_05170 ENOG4106UIA GSY53_05185 ENOG4107XC4 flavin reductase domain protein, FMN-binding GSY53_05195 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GSY53_05205 ENOG4105CAH Chromate GSY53_05210 ENOG4105FGV Chromate GSY53_05220 ENOG4108WS4 fmn reductase GSY53_05225 ENOG4107V2S Transcriptional regulator GSY53_05230 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) GSY53_05260 ENOG4108XI2 Domain of unknown function (DUF1963) GSY53_05265 ENOG4105C6Y Udp-glucose 6-dehydrogenase GSY53_05270 ENOG4108RB3 Capsular polysaccharide biosynthesis protein GSY53_05275 ENOG4107YJ4 chain length determinant protein GSY53_05280 ENOG4105HTX biosynthesis protein GSY53_05290 ENOG4105KBK Zinc finger, swim domain protein GSY53_05295 ENOG4105C0D helicase GSY53_05300 ENOG410667J hydrolase GSY53_05305 ENOG4105E98 transcriptional regulator DeoR family GSY53_05310 ENOG4105Z8H single-stranded DNA-binding protein GSY53_05340 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) GSY53_05345 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) GSY53_05355 ENOG4105CGA flagellar basal-body rod protein FlgG GSY53_05365 ENOG4105DFF Rod shape-determining protein mreb GSY53_05370 ENOG4105MT0 Sporulation transcriptional regulator spoiiid GSY53_05380 ENOG4107MII Sugar-specific transcriptional regulator TrmB GSY53_05385 ENOG4105CZM Major Facilitator GSY53_05390 ENOG4108M26 parallel beta-helix repeat protein GSY53_05395 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease GSY53_05400 ENOG41080V3 Major Facilitator superfamily GSY53_05405 ENOG4105D3W isochorismatase GSY53_05410 ENOG4107P26 GSY53_05415 ENOG4105BZU Histidine kinase GSY53_05425 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase GSY53_05435 ENOG4105FRN stage II sporulation protein GSY53_05440 ENOG4107TCE N-acetyltransferase GSY53_05460 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GSY53_05465 ENOG4107TXC Transcriptional regulator GSY53_05470 ENOG4106BRK GSY53_05475 ENOG4108RYK Nad-dependent epimerase dehydratase GSY53_05480 ENOG4108Z40 Transcriptional regulator GSY53_05485 ENOG4105CQM Urea amidohydrolase subunit alpha GSY53_05490 ENOG4105KI2 Urea amidohydrolase subunit beta GSY53_05495 ENOG4108YZ9 Urea amidohydrolase subunit gamma GSY53_05530 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) GSY53_05540 ENOG4108TF4 von Willebrand factor, type A GSY53_05555 ENOG4105JFG SpoIID LytB domain protein GSY53_05560 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GSY53_05570 ENOG4106778 Protein of unknown function (DUF1146) GSY53_05580 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) GSY53_05585 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) GSY53_05590 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) GSY53_05595 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) GSY53_05615 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) GSY53_05625 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) GSY53_05630 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) GSY53_05635 ENOG4108UIC UPF0340 protein GSY53_05640 ENOG4108YZG isomerase GSY53_05645 ENOG4107WAU Protein tyrosine phosphatase GSY53_05650 ENOG410815N Probably functions as a manganese efflux pump (By similarity) GSY53_05655 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GSY53_05665 ENOG4108ZXQ stage ii sporulation protein r GSY53_05680 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) GSY53_05685 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) GSY53_05690 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase GSY53_05700 ENOG4107TT2 Auxin Efflux Carrier GSY53_05705 ENOG4105C6K Malic enzyme GSY53_05710 ENOG4107104 thymidine kinase GSY53_05715 ENOG41082DI 50s ribosomal protein l31 GSY53_05720 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) GSY53_05730 ENOG4105CBT Fructose-1,6-bisphosphatase GSY53_05735 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) GSY53_05740 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway GSY53_05745 ENOG4105D2N Aldolase GSY53_05750 ENOG410812K response regulator receiver protein GSY53_05760 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) GSY53_05770 ENOG4105C1G acyl-Coa dehydrogenase GSY53_05775 ENOG4105DF6 Fe-S oxidoreductase GSY53_05785 ENOG4105E5J UV damage endonuclease GSY53_05795 ENOG4105NAE bifunctional deaminase-reductase domain protein GSY53_05800 ENOG4105BZ1 (ABC) transporter GSY53_05805 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) GSY53_05820 ENOG4105R3A Nitrate reductase GSY53_05825 ENOG4108IUE nitrate reductase beta subunit GSY53_05845 ENOG4107V6Q Cyclic nucleotide-binding domain GSY53_05855 ENOG4105C75 arginyL-tRNA synthetase GSY53_05860 ENOG410684U Domain of unknown function (DUF1934) GSY53_05875 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E GSY53_05925 ENOG4107JM4 Tetratricopeptide repeat GSY53_05935 ENOG4108UIN ybak prolyl-trna synthetase associated region GSY53_05940 ENOG4105CYW agmatinase GSY53_05945 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) GSY53_05950 ENOG4105BZ4 penicillin-binding protein GSY53_05955 ENOG4108XFG YwhD family GSY53_05960 ENOG4108Z4T Peptidase M50 GSY53_05965 ENOG41069HH 4-oxalocrotonate tautomerase GSY53_05970 ENOG41067TZ transcriptional regulator, MarR family GSY53_05975 ENOG4105C22 threonyL-tRNA synthetase GSY53_05980 ENOG4105C57 major facilitator superfamily GSY53_05985 ENOG41062ES Transcriptional regulator GSY53_05995 ENOG4105DCI Phosphohydrolase GSY53_06005 ENOG4108VCI transcription factor, rsfa family GSY53_06010 ENOG4108RNG Permease of the drug metabolite transporter GSY53_06015 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) GSY53_06020 ENOG4105DUM transcriptional regulator, lysR family GSY53_06025 ENOG4108IJ2 phosphate acetyltransferase GSY53_06040 ENOG4105CHM Aminotransferase GSY53_06050 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase GSY53_06055 ENOG4105CHR reductase GSY53_06060 ENOG4106CHD Bacilysin biosynthesis protein bacB GSY53_06065 ENOG41061WN bacilysin biosynthesis protein GSY53_06070 ENOG4105FCW Major Facilitator superfamily GSY53_06085 ENOG4105C26 Dehydrogenase GSY53_06090 ENOG4105D82 Glutamate dehydrogenase GSY53_06100 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase GSY53_06105 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase GSY53_06110 ENOG4105C1B dTDP-glucose 4-6-dehydratase GSY53_06115 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) GSY53_06120 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG GSY53_06125 ENOG4107TY6 Acylneuraminate cytidylyltransferase GSY53_06135 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD GSY53_06140 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase GSY53_06175 ENOG4105C26 Dehydrogenase GSY53_06180 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) GSY53_06185 ENOG4108RJ9 Glycosyl transferase, family 2 GSY53_06205 ENOG4105DWF phosphomethylpyrimidine kinase GSY53_06220 ENOG4105C5Y PTS System GSY53_06225 ENOG4108QTI )-transporter GSY53_06240 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin GSY53_06245 ENOG4105DEN Luciferase family GSY53_06250 ENOG4108DBC nitroreductase GSY53_06265 ENOG41060D1 Quinol oxidase GSY53_06270 ENOG4105CCU oxidase (Subunit III) GSY53_06275 ENOG4105BZ9 Cytochrome C oxidase, subunit I GSY53_06280 ENOG4105E2S oxidase) subunit II GSY53_06285 ENOG4107BMA Transglycosylase associated protein GSY53_06295 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) GSY53_06300 ENOG4105WH5 Teichoic acid glycosylation protein GSY53_06325 ENOG4107ZXU DSBA oxidoreductase GSY53_06330 ENOG4105DBE peroxidase GSY53_06335 ENOG410650H (LipO)protein GSY53_06340 ENOG4107SJW iron permease, FTR1 GSY53_06345 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) GSY53_06355 ENOG4105CMU LysR family (Transcriptional regulator GSY53_06360 ENOG4105VAW lrga family GSY53_06365 ENOG41067MG lrgb family GSY53_06370 ENOG4105D8G Major Facilitator superfamily GSY53_06380 ENOG4105DR4 Methyltransferase GSY53_06395 ENOG4108YV3 Protein of unknown function (DUF2711) GSY53_06400 ENOG4105CK1 PTS System GSY53_06405 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin GSY53_06420 ENOG4105X1N Glycosyl transferase family 8 GSY53_06430 ENOG4105GVJ transcriptional regulator GSY53_06435 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) GSY53_06440 ENOG4105IIU Aminopeptidase GSY53_06450 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase GSY53_06465 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) GSY53_06470 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein GSY53_06480 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD GSY53_06485 ENOG4108VHC Short-chain dehydrogenase reductase Sdr GSY53_06490 ENOG4105CM2 brancheD-chain amino acid aminotransferase GSY53_06495 ENOG4105F8D glycoside hydrolase family 4 GSY53_06500 ENOG4105VCP PTS System GSY53_06505 ENOG4105CK1 PTS System GSY53_06510 ENOG4105VZJ PTS System GSY53_06515 ENOG4105EMD TRANSCRIPTIONal GSY53_06525 ENOG4108VX5 3-methyladenine DNA glycosylase GSY53_06530 ENOG4105CH6 catalase GSY53_06545 ENOG4105DA5 (ABC) transporter GSY53_06550 ENOG41069JR GSY53_06570 ENOG4105ETS cytosine purines uracil thiamine allantoin GSY53_06575 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) GSY53_06580 ENOG4108JJ8 (ABC) transporter GSY53_06585 ENOG4108JJ9 ABC, transporter GSY53_06590 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii GSY53_06595 ENOG4105C4M (Ubiquinol oxidase) subunit I GSY53_06600 ENOG4105D2K citrate carrier protein GSY53_06615 ENOG4107BJW polysaccharide deacetylase GSY53_06635 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) GSY53_06645 ENOG4105CMR udp-glucose 4-epimerase GSY53_06655 ENOG4105BZU Histidine kinase GSY53_06660 ENOG4105WH1 Two component transcriptional regulator luxr family GSY53_06665 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GSY53_06690 ENOG4105DTD Dehydrogenase GSY53_06695 ENOG4108IIH CoA-transferase subunit B GSY53_06700 ENOG4105D6N CoA-transferase, subunit a GSY53_06705 ENOG4105CY2 Citrate transporter GSY53_06710 ENOG4105DHI Methyltransferase GSY53_06730 ENOG4105CH6 catalase GSY53_06735 ENOG4105D4T Citrate transporter GSY53_06740 ENOG4108RZ2 Glycoside hydrolase family 16 GSY53_06745 ENOG4105CID antiterminator GSY53_06755 ENOG4105DEU major facilitator superfamily GSY53_06760 ENOG4105C1J atp-dependent rna helicase GSY53_06765 ENOG4107TDE lipolytic protein G-D-S-L family GSY53_06820 ENOG4105CNA YD repeat protein GSY53_06830 ENOG4107YZX Universal stress protein GSY53_06835 ENOG4105CS2 ec 3.2.1.21 GSY53_06840 ENOG4105C5Y PTS System GSY53_06855 ENOG4107EV6 Inherit from COG: YD repeat protein GSY53_06870 ENOG4106Z5D Glycoside Hydrolase Family 43 GSY53_06880 ENOG4105C84 Histidine ammonia-lyase GSY53_06885 ENOG4105CGP Urocanate hydratase GSY53_06890 ENOG4105CI2 imidazolone-5-propionate hydrolase GSY53_06895 ENOG4107W25 arginase agmatinase formiminoglutamase GSY53_06905 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) GSY53_06910 ENOG4105D9N nucleoside GSY53_06920 ENOG4107RHR regulatoR GSY53_06925 ENOG4108TM9 integral membrane protein GSY53_06930 ENOG4105ENY Ethanolamine utilization protein eutH GSY53_06935 ENOG4108PGP mmge prpd family protein GSY53_06940 ENOG4105CH2 amidohydrolase GSY53_06950 ENOG4108HW4 amino acid AbC transporter GSY53_06955 ENOG4105EAB amino acid AbC transporter GSY53_06960 ENOG4108XSB acetyltransferase, (GNAT) family GSY53_06965 ENOG4105CPU Monooxygenase GSY53_06975 ENOG4107QHE Choloylglycine hydrolase GSY53_06980 ENOG410667J hydrolase GSY53_07010 ENOG4108V5C ABC transporter GSY53_07040 ENOG4105D2N Aldolase GSY53_07045 ENOG4107TRN Xylose isomerase domain protein TIM barrel GSY53_07050 ENOG4105F0H myo-inositol catabolism protein GSY53_07055 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GSY53_07065 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) GSY53_07070 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) GSY53_07075 ENOG4105D7K pfkb domain protein GSY53_07080 ENOG4105DH8 myo-inositol catabolism GSY53_07085 ENOG4105C26 Dehydrogenase GSY53_07095 ENOG4105CPC Aldo Keto reductase GSY53_07110 ENOG4107QNK )-transporter GSY53_07115 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) GSY53_07125 ENOG41061TZ Short-chain dehydrogenase reductase Sdr GSY53_07130 ENOG4105ST3 Transcriptional regulator GSY53_07135 ENOG4105C26 Dehydrogenase GSY53_07140 ENOG4108YM7 Gcn5-related n-acetyltransferase GSY53_07145 ENOG4105N1N Cupin superfamily protein GSY53_07150 ENOG4107Y1Y Methyltransferase GSY53_07165 ENOG4105CAQ asparagine synthetase GSY53_07170 ENOG4105F22 Major Facilitator Superfamily GSY53_07175 ENOG4108ITS PQQ enzyme repeat GSY53_07185 ENOG41085PJ rdd domain containing protein GSY53_07200 ENOG4105J7D transcriptional regulator GSY53_07205 ENOG4107JEE Short-chain dehydrogenase reductase Sdr GSY53_07210 ENOG41061AU MarR family Transcriptional regulator GSY53_07220 ENOG41067MG lrgb family GSY53_07230 ENOG4105BZW Glycerate kinase GSY53_07235 ENOG4105G3Z GntR family transcriptional regulator GSY53_07240 ENOG4105CMG Carbohydrate kinase GSY53_07245 ENOG4105C6Z Gluconate GSY53_07250 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GSY53_07255 ENOG4105D3R alkyl hydroperoxide reductase GSY53_07260 ENOG4108JU3 Alkyl hydroperoxide reductase GSY53_07265 ENOG4105CS2 ec 3.2.1.21 GSY53_07280 ENOG4108S3Y transcriptional regulator GSY53_07290 ENOG4106KKU GSY53_07295 ENOG4108Z15 abc transporter atp-binding protein GSY53_07305 ENOG4105Y2Z radical SAM domain protein GSY53_07315 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 GSY53_07330 ENOG41069I7 GSY53_07335 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) GSY53_07350 ENOG4105E2A Dehydrogenase GSY53_07370 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) GSY53_07375 ENOG4105WQG acetyltransferase GSY53_07380 ENOG410780I phosphoprotein phosphatase activity GSY53_07390 ENOG41066UZ arginase EC 3.5.3.1 GSY53_07395 ENOG4108IQI permease GSY53_07400 ENOG4105C8Y Acetylornithine aminotransferase GSY53_07405 ENOG4108JUB Transcriptional regulator GSY53_07410 ENOG4105BZU Histidine kinase GSY53_07435 ENOG4105C0H protease GSY53_07440 ENOG4105Q2H domain protein GSY53_07455 ENOG4105BZU Histidine kinase GSY53_07460 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GSY53_07485 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis GSY53_07490 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase GSY53_07495 ENOG4105CDU Replicative dna helicase GSY53_07515 ENOG4105DJ2 Major Facilitator Superfamily GSY53_07520 ENOG4105EDW glycosyl transferase, family 39 GSY53_07525 ENOG4105K9Q Binds to the 23S rRNA (By similarity) GSY53_07530 ENOG4105BZR domain protein GSY53_07535 ENOG4108XMW Membrane GSY53_07550 ENOG4105KVH Transcriptional regulator GSY53_07555 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase GSY53_07570 ENOG41090E6 transcriptional regulator MERR family GSY53_07580 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein GSY53_07585 ENOG4105DDN Pentapeptide repeat-containing protein GSY53_07590 ENOG4105D94 Major Facilitator Superfamily GSY53_07595 ENOG4107RSM transcriptional regulator GSY53_07600 ENOG41082BV acetyltransferase GSY53_07605 ENOG41081I9 integral membrane protein GSY53_07615 ENOG4108U05 Transcriptional regulator GSY53_07620 ENOG41082BV acetyltransferase GSY53_07630 ENOG4108U7W acetyltransferase GSY53_07635 ENOG4105UNS Pfam:DUF419 GSY53_07640 ENOG4105NAE bifunctional deaminase-reductase domain protein GSY53_07650 ENOG4108J8C transporter major facilitator family protein GSY53_07670 ENOG4108IPJ Membrane GSY53_07675 ENOG4105C7Z Conserved Protein GSY53_07680 ENOG4107FCW Abortive infection protein GSY53_07690 ENOG4108UW5 maltose o-acetyltransferase GSY53_07695 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase GSY53_07705 ENOG4105CGK Exodeoxyribonuclease III GSY53_07710 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) GSY53_07715 ENOG4108UUM single-stranded DNA-binding protein GSY53_07720 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) GSY53_07725 ENOG4105C3G gtp-binding protein GSY53_07730 ENOG4108J2R molybdopterin oxidoreductase GSY53_07735 ENOG4105VDK protein, conserved in bacteria GSY53_07745 ENOG4108ZDA Sporulation protein YyaC GSY53_07750 ENOG4105FA0 parb-like partition protein GSY53_07755 ENOG4107QJE Chromosome Partitioning Protein GSY53_07770 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) GSY53_07775 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) GSY53_07780 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) GSY53_07795 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) GSY53_07805 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) GSY53_07810 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) GSY53_07815 ENOG410848D S4 domain protein YaaA GSY53_07830 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GSY53_07835 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GSY53_07870 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) GSY53_07880 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) GSY53_07885 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) GSY53_07890 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) GSY53_07900 ENOG4105ZMH deoxynucleoside kinase GSY53_07910 ENOG4105VRS hydrolase family 18 GSY53_07915 ENOG4105GTG Isochorismatase GSY53_07920 ENOG4108Z6B deaminase GSY53_07930 ENOG4105C6E dna polymerase iii GSY53_07935 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) GSY53_07940 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) GSY53_07950 ENOG41067KS pro-sigma K processing GSY53_07990 ENOG4105CDW Resistance protein GSY53_07995 ENOG4105CXN decarboxylase GSY53_08000 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) GSY53_08005 ENOG4105X0R protein from nitrogen regulatory protein P-II GSY53_08010 ENOG4105XVJ Protein of unknown function (DUF327) GSY53_08015 ENOG4105FA2 dna polymerase iii GSY53_08020 ENOG4105MA4 psp1 domain protein GSY53_08025 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) GSY53_08030 ENOG41060K3 Methyltransferase GSY53_08035 ENOG4105VC4 domain protein GSY53_08040 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) GSY53_08045 ENOG4105KRN Transcriptional regulator, abrb family GSY53_08050 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) GSY53_08055 ENOG4105F8V Hydrolase, tatD family GSY53_08060 ENOG41069ER domain protein GSY53_08070 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) GSY53_08075 ENOG4105XFA sporulation peptidase YabG GSY53_08080 ENOG4105W42 Veg protein GSY53_08085 ENOG4105XEW small acid-soluble spore protein GSY53_08090 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) GSY53_08095 ENOG4105DFT pur operon repressor GSY53_08100 ENOG4105KME endoribonuclease L-psp GSY53_08105 ENOG4105K4W Could be involved in septation (By similarity) GSY53_08110 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) GSY53_08115 ENOG4105C5T Phosphoribosyl pyrophosphate synthase GSY53_08120 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) GSY53_08125 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) GSY53_08135 ENOG4108JA2 transcriptioN-repair coupling factor GSY53_08140 ENOG4108M14 stage v sporulation protein t GSY53_08150 ENOG4108IY2 MazG family GSY53_08155 ENOG41082I2 s4 domain protein GSY53_08160 ENOG4105VYY sporulation protein yabp GSY53_08175 ENOG41060GV RNA binding s1 domain protein GSY53_08205 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) GSY53_08210 ENOG4108UGV hypoxanthine phosphoribosyltransferase GSY53_08215 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) GSY53_08225 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) GSY53_08230 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase GSY53_08235 ENOG4105C6T cysteine synthase GSY53_08240 ENOG4105CRQ synthase (Component I) GSY53_08245 ENOG4105DDQ anthranilate synthase GSY53_08250 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 GSY53_08255 ENOG4105EEI dihydropteroate synthase GSY53_08260 ENOG4105KRF dihydroneopterin aldolase GSY53_08265 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase GSY53_08275 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) GSY53_08280 ENOG4105CRK lysyL-tRNA synthetase GSY53_08365 ENOG4108Z0C Uvrb UvrC protein GSY53_08370 ENOG41066A3 ATP guanido phosphotransferase GSY53_08380 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) GSY53_08385 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) GSY53_08390 ENOG4105CTP PilT protein domain protein GSY53_08395 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) GSY53_08400 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) GSY53_08405 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) GSY53_08410 ENOG4105D7W serine acetyltransferase GSY53_08415 ENOG4105C8N cysteinyl-tRNA synthetase GSY53_08420 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) GSY53_08425 ENOG4105C2N RNA methyltransferase TrmH family group 3 GSY53_08430 ENOG4105M0M Tetracycline resistance protein GSY53_08450 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) GSY53_08455 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) GSY53_08465 ENOG4108VZM 50s ribosomal protein L10 GSY53_08470 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) GSY53_08475 ENOG4107Y49 methyltransferase GSY53_08480 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GSY53_08485 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GSY53_08490 ENOG4105XPM ribosomal protein GSY53_08495 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) GSY53_08500 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) GSY53_08505 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) GSY53_08510 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) GSY53_08515 ENOG4107SKW Inherit from COG: Alpha beta hydrolase GSY53_08520 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) GSY53_08525 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) GSY53_08530 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) GSY53_08535 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) GSY53_08540 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity GSY53_08545 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) GSY53_08550 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) GSY53_08555 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) GSY53_08560 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) GSY53_08565 ENOG41082SA 50s ribosomal protein l29 GSY53_08570 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal GSY53_08575 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) GSY53_08585 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits GSY53_08595 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) GSY53_08600 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) GSY53_08605 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) GSY53_08610 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) GSY53_08615 ENOG4105VPB 50S ribosomal protein L30 GSY53_08620 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) GSY53_08625 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) GSY53_08635 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) GSY53_08645 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) GSY53_08655 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits GSY53_08660 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) GSY53_08665 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) GSY53_08670 ENOG4108ZT0 50S ribosomal protein l17 GSY53_08675 ENOG4108JJB ABC transporter GSY53_08680 ENOG4108JJB ABC transporter GSY53_08685 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) GSY53_08690 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) GSY53_08695 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) GSY53_08700 ENOG4108UJD 30S ribosomal protein S9 GSY53_08705 ENOG4108I0C methyltransferase GSY53_08720 ENOG4105D1F ATP-binding protein GSY53_08735 ENOG4108NMV polysaccharide deacetylase GSY53_08815 ENOG4105CHH sulfate transporter GSY53_08825 ENOG4108SA1 esterase GSY53_08845 ENOG410874W AraC family transcriptional regulator GSY53_08850 ENOG4105EHZ conserved protein UCP016719 GSY53_08855 ENOG4105D17 glycoside hydrolase, family 3 domain protein GSY53_08875 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate GSY53_08885 ENOG4105EWC Purine nucleoside phosphorylase GSY53_08915 ENOG4105EMN RNA polymerase sigma factor GSY53_08925 ENOG4105C8B TIGR00159 family GSY53_08930 ENOG4107U5W ybbr family GSY53_08935 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) GSY53_08940 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) GSY53_08950 ENOG4105D03 DNA-3-methyladenine glycosylase II GSY53_08960 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GSY53_08965 ENOG4108TWJ NADH dehydrogenase subunit 5 GSY53_08985 ENOG4105GPN Uncharacterized conserved protein (DUF2294) GSY53_08990 ENOG4105WAB arsR family transcriptional regulator GSY53_08995 ENOG4108RWP Major Facilitator Superfamily protein GSY53_09010 ENOG4107ZBH radical SAM domain protein GSY53_09015 ENOG41066N6 Abortive infection protein GSY53_09020 ENOG4108WUZ (ABC) transporter GSY53_09060 ENOG4105G0J serine threonine protein kinase GSY53_09070 ENOG4106K80 GSY53_09080 ENOG4106DDH Sporulation-specific SASP protein GSY53_09090 ENOG4108HWY Beta-lactamase GSY53_09095 ENOG4107E6A Cytochrome p-450 GSY53_09105 ENOG4107QTZ amino acid GSY53_09110 ENOG4107VXM glycerophosphoryl diester phosphodiesterase GSY53_09115 ENOG4105CXY transporter GSY53_09125 ENOG410645S MarR family Transcriptional regulator GSY53_09130 ENOG4105DCM major facilitator superfamily GSY53_09150 ENOG410631K Membrane GSY53_09155 ENOG4106AXJ AraC family transcriptional regulator GSY53_09160 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR GSY53_09165 ENOG4108TCS Glutamyl endopeptidase GSY53_09175 ENOG4108WC5 Alpha Beta Hydrolase Fold protein GSY53_09180 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase GSY53_09185 ENOG4107ZTW SNARE associated Golgi GSY53_09210 ENOG4105C72 UPF0176 protein GSY53_09220 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane GSY53_09225 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) GSY53_09230 ENOG4108X79 transcriptional regulator GSY53_09240 ENOG4105CM2 brancheD-chain amino acid aminotransferase GSY53_09245 ENOG4108IQI permease GSY53_09250 ENOG4108J5H Homocysteine s-methyltransferase GSY53_09265 ENOG4105CSV Glutaminase GSY53_09280 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase GSY53_09285 ENOG4105C26 Dehydrogenase GSY53_09290 ENOG4105DJB Major Facilitator Superfamily GSY53_09295 ENOG4105EQX glucarate dehydratase GSY53_09300 ENOG41073TP transcriptional regulator GSY53_09305 ENOG4105CTX dehydratase GSY53_09320 ENOG4106UX7 integral membrane protein GSY53_09325 ENOG4105DPZ Two component transcriptional regulator (Winged helix family GSY53_09360 ENOG4105MUA Resistance protein GSY53_09370 ENOG4105DGI Alkaline phosphatase GSY53_09375 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GSY53_09380 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GSY53_09385 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) GSY53_09390 ENOG4107EPV Aminotransferase class V GSY53_09395 ENOG4105C0R drug resistance transporter emrb qaca subfamily GSY53_09400 ENOG4105J7D transcriptional regulator GSY53_09405 ENOG4107RB3 L-asparaginase GSY53_09410 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold GSY53_09420 ENOG41060AI SEC-C motif GSY53_09430 ENOG4107Y7X LytTR GSY53_09435 ENOG4108IUW ABC transporter GSY53_09440 ENOG4108SDH ABC, transporter GSY53_09445 ENOG4107SET aldo keto reductase GSY53_09480 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GSY53_09490 ENOG4105DSE periplasmic solute binding protein GSY53_09495 ENOG4105DIK (ABC) transporter GSY53_09505 ENOG4105DEN Luciferase family GSY53_09510 ENOG4108N0M stress protein GSY53_09515 ENOG4106FN3 tellurium resistance protein GSY53_09520 ENOG4106FN3 tellurium resistance protein GSY53_09525 ENOG4107TS3 membrane protein, TerC GSY53_09530 ENOG4108TTB tellurium resistance protein GSY53_09540 ENOG41079KZ Major Facilitator Superfamily GSY53_09545 ENOG4107XZQ multidrug resistance protein GSY53_09550 ENOG4108A65 Transcriptional regulator GSY53_09555 ENOG4108IJ7 Glycine betaine GSY53_09560 ENOG4107SQ8 Glycine betaine GSY53_09590 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) GSY53_09625 ENOG4105EIG urea carboxylase-associated protein 1 GSY53_09630 ENOG4107RA1 nh(3)-dependent nad( ) synthetase GSY53_09635 ENOG4105I1F Resistance protein GSY53_09640 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) GSY53_09645 ENOG41089UC methyltransferase, type 11 GSY53_09650 ENOG4105C5Q Transcriptional regulator GSY53_09655 ENOG4105I82 acetyl xylan esterase GSY53_09660 ENOG410756H nucleotidyltransferase GSY53_09670 ENOG4105C26 Dehydrogenase GSY53_09675 ENOG4105CK7 Sodium proline symporter GSY53_09680 ENOG4107YHD transcriptional regulator GSY53_09690 ENOG4108PJD permease GSY53_09695 ENOG4105U6C Alpha beta hydrolase fold protein GSY53_09705 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GSY53_09710 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit GSY53_09715 ENOG4108IFG nitrite reductase, (NAD(P)H) GSY53_09720 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) GSY53_09740 ENOG4105S7A ErfK ybiS ycfS ynhG family protein GSY53_09750 ENOG4105CKI cobalamin synthesis protein GSY53_09755 ENOG4105E5Q amino acid AbC transporter GSY53_09760 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein GSY53_09780 ENOG4105CS2 ec 3.2.1.21 GSY53_09795 ENOG4105C8Q Methyl-accepting chemotaxis GSY53_09800 ENOG41080HJ 6-phospho 3-hexuloisomerase GSY53_09805 ENOG4108VA3 3-hexulose-6-phosphate synthase GSY53_09810 ENOG4105KVH Transcriptional regulator GSY53_09815 ENOG4105CEY Amp-dependent synthetase and ligase GSY53_09845 ENOG4105SX7 Transporter GSY53_09855 ENOG4105W8Z 4'-phosphopantetheinyl transferase GSY53_09865 ENOG4105CDA abc transporter atp-binding protein GSY53_09870 ENOG4105DRP amino acid AbC transporter GSY53_09880 ENOG4106P55 Transcriptional regulator GSY53_09885 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase GSY53_09890 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) GSY53_09895 ENOG41069ZX GSY53_09900 ENOG41069ZX GSY53_09910 ENOG4105DUX Transporter GSY53_09925 ENOG4105E1K spore germination protein GSY53_09945 ENOG4107WD8 ABC transporter, permease GSY53_09950 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GSY53_09955 ENOG4105BZU Histidine kinase GSY53_09980 ENOG4105CFH Aspartokinase GSY53_09985 ENOG4105DHS permease protein GSY53_09990 ENOG4105CM4 permease protein GSY53_09995 ENOG4108IPW abc transporter atp-binding protein GSY53_10010 ENOG4105R8C Transcriptional regulator GSY53_10015 ENOG4108DBC nitroreductase GSY53_10020 ENOG41067V3 Antibiotic biosynthesis monooxygenase GSY53_10025 ENOG4105YVS arsR family transcriptional regulator GSY53_10035 ENOG4108JPW Aminotransferase GSY53_10040 ENOG4105C26 Dehydrogenase GSY53_10050 ENOG4105H9W Short-chain dehydrogenase reductase Sdr GSY53_10055 ENOG4105KTB nuclear export factor GLE1 GSY53_10060 ENOG4108T5E Copper resistance protein GSY53_10065 ENOG4108ZYE Transcriptional regulator GSY53_10090 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) GSY53_10095 ENOG4108ZX0 Signal peptidase I GSY53_10120 ENOG4105E7W lamb ycsf family protein GSY53_10125 ENOG4105C5A transporter GSY53_10130 ENOG4105CFM UPF0317 protein GSY53_10135 ENOG4105P4J Allophanate hydrolase, subunit 1 GSY53_10145 ENOG4107258 Transcriptional regulator GSY53_10150 ENOG4105XJB lipolytic protein G-D-S-L family GSY53_10160 ENOG41061CK Antibiotic biosynthesis monooxygenase GSY53_10165 ENOG4107RVG penicillin-binding protein GSY53_10170 ENOG4107QM2 Aldo Keto reductase GSY53_10175 ENOG4105ETD TRANSCRIPTIONal GSY53_10185 ENOG4105HMZ Methyltransferase GSY53_10190 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GSY53_10205 ENOG410606W general stress protein GSY53_10215 ENOG4105VCH membrane GSY53_10225 ENOG4105C9U ATP-dependent DNA helicase RecQ GSY53_10240 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) GSY53_10245 ENOG4107R8N Glycosyl transferase, family 2 GSY53_10255 ENOG4105C0X amino acid GSY53_10280 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) GSY53_10290 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) GSY53_10295 ENOG4105EU9 GSY53_10300 ENOG4105QVS general stress protein GSY53_10305 ENOG41082W1 Cupin 2, conserved barrel domain protein GSY53_10320 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit GSY53_10325 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism GSY53_10330 ENOG4108MRH transcriptional regulatory protein GSY53_10335 ENOG4107QJT sodium dicarboxylate symporter GSY53_10340 ENOG4106F5Q Membrane GSY53_10345 ENOG4105CJ1 ABC, transporter GSY53_10360 ENOG4105FDT acyl-CoA dehydrogenase GSY53_10380 ENOG4105SZ6 Thioredoxin GSY53_10385 ENOG4105CPF Cell wall formation (By similarity) GSY53_10390 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) GSY53_10395 ENOG4105C1J atp-dependent rna helicase GSY53_10400 ENOG410905X membrane-flanked domain protein GSY53_10405 ENOG4105CKV Membrane GSY53_10415 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) GSY53_10420 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein GSY53_10425 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GSY53_10435 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) GSY53_10440 ENOG4107MMM Anti-sigma-factor antagonist GSY53_10445 ENOG4105FUA antagonist GSY53_10450 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase GSY53_10455 ENOG4107SGM protein serine threonine phosphatase GSY53_10460 ENOG4105WN5 stage II sporulation protein GSY53_10465 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GSY53_10475 ENOG41064BQ Phosphatase GSY53_10490 ENOG4105M5P UPF0310 protein GSY53_10495 ENOG4105RV9 Transcriptional regulator GSY53_10550 ENOG4105DEN Luciferase family GSY53_10565 ENOG4108W2Y isochorismatase GSY53_10570 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein GSY53_10575 ENOG4108HH4 Major Facilitator Superfamily GSY53_10595 ENOG4108V4B ThiJ pfpI GSY53_10600 ENOG4105VEQ Cold shock protein GSY53_10605 ENOG4108VJ1 Transcriptional regulator (CarD family GSY53_10615 ENOG4108MCI Transcriptional regulator, ARAC family GSY53_10620 ENOG4108UZ3 Transporter GSY53_10625 ENOG41086D8 Transcriptional regulator GSY53_10630 ENOG4107U9B transcriptional regulator GSY53_10635 ENOG4105DXI Major Facilitator superfamily GSY53_10645 ENOG4105CZ9 Domain of unknown function (DU1801) GSY53_10650 ENOG4105GIG GSY53_10655 ENOG4105T38 integral membrane protein GSY53_10660 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GSY53_10665 ENOG4108ZMQ domain protein GSY53_10670 ENOG4105MJ9 esterase GSY53_10675 ENOG4107Z6X Transcriptional regulator GSY53_10685 ENOG4105KVH Transcriptional regulator GSY53_10690 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein GSY53_10695 ENOG4105EQ0 Major Facilitator superfamily GSY53_10700 ENOG4108JGH Tetr family transcriptional regulator GSY53_10710 ENOG41082YX Transcriptional regulator, arsr family GSY53_10715 ENOG4107R5R arsenical pump membrane protein GSY53_10725 ENOG4105Z7P Acetyltransferase (GNAT) family GSY53_10730 ENOG4107Y9U Membrane GSY53_10740 ENOG4108SQ9 flavin reductase domain protein, FMN-binding GSY53_10745 ENOG4108ZHR arsR family transcriptional regulator GSY53_10750 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) GSY53_10765 ENOG4105ENE Histidine kinase GSY53_10770 ENOG4108VB1 regulatoR GSY53_10775 ENOG4105EYF MMPL domain protein GSY53_10780 ENOG4108WC5 Alpha Beta Hydrolase Fold protein GSY53_10785 ENOG4108UQV Membrane GSY53_10790 ENOG4108Z5V transcriptional regulator, merr family GSY53_10795 ENOG41076HS cation diffusion facilitator family transporter GSY53_10800 ENOG4108TVJ Nitroreductase GSY53_10805 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase GSY53_10810 ENOG4108VGI doxx family GSY53_10815 ENOG4105XXY Thioredoxin GSY53_10830 ENOG410900G Protein of unknown function (DUF421) GSY53_10835 ENOG4108QY0 Membrane GSY53_10855 ENOG4105PF9 Transcriptional regulator GSY53_10865 ENOG4105WQG acetyltransferase GSY53_10875 ENOG4105C85 amino acid GSY53_10885 ENOG41062A4 Transcriptional regulator GSY53_10890 ENOG4105EYF MMPL domain protein GSY53_10895 ENOG4108TVJ Nitroreductase GSY53_10900 ENOG4105FS7 Transcriptional regulator GSY53_10905 ENOG4105C2C drug resistance transporter, Bcr CflA GSY53_10915 ENOG4105DRR Transcriptional regulator, GntR family GSY53_10920 ENOG4105VRS hydrolase family 18 GSY53_10935 ENOG4105G6Z alkaline phosphatase GSY53_10940 ENOG4108ZMX Domain of unknown function (DU1801) GSY53_10950 ENOG4108YM7 Gcn5-related n-acetyltransferase GSY53_10955 ENOG4107TVP HD domain protein GSY53_10960 ENOG41090UD (LipO)protein GSY53_10965 ENOG4105F27 Major Facilitator GSY53_10970 ENOG4105VZJ PTS System GSY53_10975 ENOG4105VCP PTS System GSY53_10980 ENOG4105CK1 PTS System GSY53_10985 ENOG4105CS2 ec 3.2.1.21 GSY53_10990 ENOG4108TZY GntR Family Transcriptional Regulator GSY53_10995 ENOG4105EVU fructokinase GSY53_11000 ENOG4105DG6 mannose-6-phosphate isomerase GSY53_11005 ENOG4105D3P Mannan endo-1,4-beta-mannosidase GSY53_11050 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) GSY53_11055 ENOG4105K8N protein family UPF0079, ATPase GSY53_11060 ENOG41072GX Peptidase M22 Glycoprotease GSY53_11065 ENOG410801F ribosomal-protein-alanine acetyltransferase GSY53_11070 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) GSY53_11075 ENOG4105C5H ABC transporter GSY53_11080 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) GSY53_11085 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) GSY53_11090 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) GSY53_11095 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) GSY53_11105 ENOG4108TYN CAAX amino terminal protease family protein GSY53_11110 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) GSY53_11115 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) GSY53_11140 ENOG4105DVF Cytosine-specific methyltransferase GSY53_11145 ENOG4107RHI Cytosine-specific methyltransferase GSY53_11185 ENOG4105PGZ NB-ARC domain GSY53_11190 ENOG4105CPQ Dehydrogenase GSY53_11195 ENOG4105CT4 transporter GSY53_11205 ENOG41087YS Phage shock protein A GSY53_11210 ENOG4105DQX Zinc finger domain GSY53_11215 ENOG4108WV1 Pfam:DUF477 GSY53_11225 ENOG4108ZMR Ion transport 2 domain-containing protein GSY53_11230 ENOG4107QNK )-transporter GSY53_11260 ENOG4107YUH hydrolase GSY53_11270 ENOG4107STQ Multicopper oxidase GSY53_11275 ENOG4105C85 amino acid GSY53_11290 ENOG4105C7R Atpase associated with various cellular activities aaa_3 GSY53_11310 ENOG4105C7N Xanthine uracil vitamin C permease GSY53_11335 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) GSY53_11340 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit GSY53_11345 ENOG4105C83 adenylosuccinate lyase GSY53_11350 ENOG4105C8V SAICAR synthetase GSY53_11355 ENOG4105VR9 phosphoribosylformylglycinamidine synthase GSY53_11360 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I GSY53_11365 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii GSY53_11375 ENOG4105CXB phosphoribosylaminoimidazole synthetase GSY53_11380 ENOG4108V3E phosphoribosylglycinamide formyltransferase GSY53_11385 ENOG4105DC1 bifunctional purine biosynthesis protein purh GSY53_11390 ENOG4105C12 Phosphoribosylglycinamide synthetase GSY53_11400 ENOG4105DVH amino acid GSY53_11415 ENOG4108R5T secreted protein GSY53_11420 ENOG4105KGF protein, YerC YecD GSY53_11425 ENOG4105CBC glutamate synthase GSY53_11430 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) GSY53_11435 ENOG4105C4R Atp-dependent dna helicase GSY53_11440 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) GSY53_11450 ENOG4105CRN Aminoglycoside phosphotransferase GSY53_11455 ENOG4105KT7 mgtC SapB transporter GSY53_11460 ENOG4105CK7 Sodium proline symporter GSY53_11465 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GSY53_11470 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) GSY53_11475 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) GSY53_11480 ENOG4108IG5 Transcriptional regulator GSY53_11490 ENOG4105CBD Diacylglycerol kinase GSY53_11495 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GSY53_11510 ENOG4105D85 methylase GSY53_11515 ENOG4105F6A helicase GSY53_11520 ENOG4105ECI YeeC-like protein GSY53_11570 ENOG4105CDY transcriptional regulatory protein GSY53_11580 ENOG4105M4P Tetr family transcriptional regulator GSY53_11585 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein GSY53_11590 ENOG4107S9F NmrA family GSY53_11605 ENOG4105WEF catalase GSY53_11610 ENOG4105M18 -acetyltransferase GSY53_11625 ENOG4105C2F Histidine kinase GSY53_11630 ENOG4105EQD regulatoR GSY53_11635 ENOG410769Z extracellular solute-binding protein family 1 GSY53_11640 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component GSY53_11645 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component GSY53_11650 ENOG4105F5H Glycosyl Hydrolase Family 88 GSY53_11655 ENOG41075H3 AraC family transcriptional regulator GSY53_11660 ENOG4107TDE lipolytic protein G-D-S-L family GSY53_11675 ENOG4105CX8 fg-gap repeat protein GSY53_11680 ENOG4105CX8 fg-gap repeat protein GSY53_11685 ENOG4107TDE lipolytic protein G-D-S-L family GSY53_11695 ENOG4105EKC GSY53_11700 ENOG4105E0S extracellular solute-binding protein family 1 GSY53_11710 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component GSY53_11715 ENOG4105F8D glycoside hydrolase family 4 GSY53_11720 ENOG4105H67 Protein of unknown function (DUF421) GSY53_11725 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) GSY53_11730 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily GSY53_11750 ENOG4106I4J membrane GSY53_11755 ENOG4108PCN EamA-like transporter family GSY53_11760 ENOG41082F9 transcriptional regulator GSY53_11765 ENOG41061H0 Monooxygenase GSY53_11770 ENOG4108R1P GSY53_11775 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) GSY53_11780 ENOG4105E0M Sulfatase GSY53_11785 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase GSY53_11795 ENOG41090R9 glycosyltransferase GSY53_11800 ENOG4107R51 Glycosyl transferase, family 2 GSY53_11805 ENOG41090R9 glycosyltransferase GSY53_11820 ENOG4105CUB amino acid GSY53_11825 ENOG4105C26 Dehydrogenase GSY53_11830 ENOG4105FKZ Methyl-accepting chemotaxis GSY53_11835 ENOG4105C5H ABC transporter GSY53_11845 ENOG4107SWG transcriptional regulator MERR family GSY53_11850 ENOG4105DXB Major Facilitator superfamily GSY53_11860 ENOG4105C5H ABC transporter GSY53_11865 ENOG4105FDU atp-dependent rna helicase GSY53_11875 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein GSY53_11885 ENOG4105E6M Sulphatase-modifying factor protein GSY53_11890 ENOG4105E0A ABC, transporter GSY53_11895 ENOG4108U1V ABC transporter, permease GSY53_11900 ENOG4105DQ5 transport system permease protein GSY53_11905 ENOG4108HUF Transporter GSY53_11920 ENOG4108J20 pectate lyase GSY53_11925 ENOG4107QPK )-transporter GSY53_11935 ENOG4108MRH transcriptional regulatory protein GSY53_11960 ENOG410855V Acylphosphatase GSY53_11965 ENOG4108RPX mosc domain containing protein GSY53_11985 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) GSY53_12015 ENOG4105GEU Spore germination protein GSY53_12025 ENOG4108Q5U germination protein, ger(x)c family GSY53_12030 ENOG4105E1K spore germination protein GSY53_12035 ENOG4105C5Y PTS System GSY53_12040 ENOG4105CG3 alpha amylase, catalytic region GSY53_12045 ENOG4107414 GntR family transcriptional regulator GSY53_12050 ENOG4108RCM Nitroreductase GSY53_12055 ENOG4105CGH 5'-nucleotidase GSY53_12060 ENOG4107RKG DJ-1/PfpI family GSY53_12075 ENOG4105KJF protein tyrosine phosphatase GSY53_12085 ENOG4107U9T Pfam:Ribonuclease_BN GSY53_12090 ENOG4108ISG Major Facilitator GSY53_12095 ENOG4105UPD Calcium Proton GSY53_12105 ENOG4105D8X mechanosensitive ion channel GSY53_12125 ENOG4106KE4 Dehydrogenase GSY53_12130 ENOG4105D7N magnesium and cobalt transport protein CorA GSY53_12140 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) GSY53_12165 ENOG4107RUY (E1 component), alpha subunit GSY53_12175 ENOG4107QKR Dehydrogenase GSY53_12185 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family GSY53_12190 ENOG41069DP small acid-soluble spore protein GSY53_12195 ENOG4105KK4 UPF0060 membrane protein GSY53_12225 ENOG4105F8D glycoside hydrolase family 4 GSY53_12230 ENOG4108Q3X Transcriptional regulator GSY53_12235 ENOG4105CI1 PTS System GSY53_12240 ENOG4105BZ1 (ABC) transporter GSY53_12245 ENOG4105BZ1 (ABC) transporter GSY53_12255 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase GSY53_12260 ENOG4105ID8 Transcriptional regulator, ARAC family GSY53_12265 ENOG4107QNK )-transporter GSY53_12270 ENOG4107QP6 Xylose isomerase domain protein TIM barrel GSY53_12275 ENOG4105CIB oxidoreductase Domain protein GSY53_12280 ENOG4105BZU Histidine kinase GSY53_12285 ENOG4105WH1 Two component transcriptional regulator luxr family GSY53_12290 ENOG4105CJ1 ABC, transporter GSY53_12295 ENOG41090VJ ABC-2 type transporter GSY53_12300 ENOG4108KYE ABC-2 type transporter GSY53_12305 ENOG4105U3E Transcriptional regulator GSY53_12310 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold GSY53_12315 ENOG4105H93 Acyltransferase family GSY53_12320 ENOG4105YA8 Transcriptional regulator GSY53_12325 ENOG4107Y80 Major Facilitator superfamily GSY53_12330 ENOG4108YYS metal-dependent hydrolase (By similarity) GSY53_12335 ENOG4105C0R drug resistance transporter emrb qaca subfamily GSY53_12340 ENOG410834F Transcriptional regulator GSY53_12350 ENOG4108MES Periplasmic binding protein GSY53_12355 ENOG4105DQ5 transport system permease protein GSY53_12360 ENOG4108IHU transport system permease protein GSY53_12365 ENOG4105JAB phenazine biosynthesis protein, phzf family GSY53_12370 ENOG4107Y03 Nitroreductase GSY53_12385 ENOG4105ECP epimerase GSY53_12400 ENOG4105F27 Major Facilitator GSY53_12420 ENOG4106AKJ GSY53_12425 ENOG4105D74 hydrolase GSY53_12430 ENOG4105CKK Glycosyl transferase, family 2 GSY53_12435 ENOG4105EJV Membrane GSY53_12440 ENOG41067AE Membrane-bound metal-dependent hydrolase GSY53_12445 ENOG4105CEN a g-specific adenine glycosylase GSY53_12450 ENOG4106BXE GSY53_12455 ENOG4105CAN Short-chain dehydrogenase reductase Sdr GSY53_12470 ENOG4105EVI UPF0374 protein GSY53_12475 ENOG4105BZ1 (ABC) transporter GSY53_12480 ENOG4107NBY Membrane GSY53_12490 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GSY53_12495 ENOG4105G5W regulator Fur family GSY53_12605 ENOG4108N23 SpoOM-related protein GSY53_12620 ENOG4105EC3 peptidase S51, dipeptidase E GSY53_12625 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) GSY53_12630 ENOG4105DNP FAD linked oxidase domain protein GSY53_12645 ENOG4105E2Y ABC, transporter GSY53_12650 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein GSY53_12655 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component GSY53_12660 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) GSY53_12670 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) GSY53_12675 ENOG4107D63 GSY53_12680 ENOG4105VZ8 Transcriptional regulator GSY53_12695 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) GSY53_12705 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) GSY53_12725 ENOG4105CYN Serine protein kinase GSY53_12730 ENOG4106AKX UPF0229 protein GSY53_12735 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes GSY53_12740 ENOG4105CW7 secretion protein, HlyD family GSY53_12745 ENOG4105C0R drug resistance transporter emrb qaca subfamily GSY53_12750 ENOG4105CS1 NAD(P)H quinone oxidoreductase GSY53_12770 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family GSY53_12775 ENOG4105CZV ABC transporter GSY53_12780 ENOG4105CJ1 ABC, transporter GSY53_12785 ENOG4108TU7 Inherit from COG: (ABC) transporter GSY53_12790 ENOG4105VEQ Cold shock protein GSY53_12800 ENOG4105BZU Histidine kinase GSY53_12840 ENOG4108YBP pseudouridine synthase GSY53_12850 ENOG41080XP Cbs domain GSY53_12855 ENOG4107YBY Hydrolase GSY53_12860 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GSY53_12865 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GSY53_12870 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator GSY53_12880 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) GSY53_12885 ENOG4105C6V Glycerol-3-phosphate dehydrogenase GSY53_12895 ENOG4105BZU Histidine kinase GSY53_12900 ENOG4105WH1 Two component transcriptional regulator luxr family GSY53_12935 ENOG4105ED1 spovr family GSY53_12940 ENOG4105G6Z alkaline phosphatase GSY53_12955 ENOG4105BZN citrate synthase GSY53_12960 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GSY53_12965 ENOG4105CUB amino acid GSY53_12970 ENOG4105C8J )-transporter GSY53_12975 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GSY53_12990 ENOG4105J37 GSY53_12995 ENOG4108AEY RNA polymerase sigma factor GSY53_13000 ENOG4108FN7 Aldo keto reductase GSY53_13005 ENOG4105F6E Acyl-transferase GSY53_13010 ENOG4105C37 (CBS) domain GSY53_13020 ENOG4105CHM Aminotransferase GSY53_13025 ENOG4105C37 (CBS) domain GSY53_13035 ENOG4105WMR Protein CrcB homolog GSY53_13040 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GSY53_13050 ENOG4105D64 Mechanosensitive ion channel GSY53_13055 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) GSY53_13060 ENOG4107VMI polysaccharide deacetylase GSY53_13065 ENOG4105F0I Aminotransferase GSY53_13085 ENOG4105BZ1 (ABC) transporter GSY53_13090 ENOG4105BZ1 (ABC) transporter GSY53_13115 ENOG410839P GSY53_13125 ENOG4106MP8 UPF0754 membrane protein GSY53_13130 ENOG4105WZB UPF0342 protein GSY53_13135 ENOG4105F1N DNA alkylation repair GSY53_13145 ENOG4105D4P Coproporphyrinogen iii oxidase GSY53_13150 ENOG4107S91 Sodium hydrogen exchanger GSY53_13155 ENOG4105NCW Trka-c domain protein GSY53_13165 ENOG4105CGU Enoyl-CoA hydratase GSY53_13175 ENOG4108IUX (ABC) transporter GSY53_13180 ENOG4105RHA ABC transporter, permease GSY53_13185 ENOG4107VRP DNA repair exonuclease GSY53_13190 ENOG4106D4I domain protein GSY53_13195 ENOG4105EQI Metal Dependent Phosphohydrolase GSY53_13205 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) GSY53_13250 ENOG4105NBU tryptophan transport protein GSY53_13255 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) GSY53_13260 ENOG4105K59 histidine triad (HIT) protein GSY53_13295 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation GSY53_13300 ENOG4105BZ4 penicillin-binding protein GSY53_13305 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) GSY53_13310 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) GSY53_13315 ENOG4105C1Q protoporphyrinogen oxidase GSY53_13325 ENOG4105ECB domain protein GSY53_13335 ENOG41090T1 Membrane GSY53_13345 ENOG4105DER m42 family GSY53_13360 ENOG4106AXD GSY53_13365 ENOG4108RQ5 Beta-lactamase domain-containing protein GSY53_13370 ENOG4105DF9 Lipoate-protein, ligase GSY53_13380 ENOG4105CEY Amp-dependent synthetase and ligase GSY53_13390 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 GSY53_13400 ENOG4105KD7 acetyltransferase GSY53_13410 ENOG4108HUF Transporter GSY53_13415 ENOG4107TB6 phosphoglycerate mutase GSY53_13425 ENOG4107F3J Amp-dependent synthetase and ligase GSY53_13430 ENOG4107ZYJ bioY protein GSY53_13435 ENOG4106YBV Methyl-accepting chemotaxis GSY53_13455 ENOG4105XVF Competence transcription factor GSY53_13460 ENOG4105CYX Short-chain dehydrogenase reductase Sdr GSY53_13465 ENOG4105X3H Excalibur domain protein GSY53_13470 ENOG4105E1V na solute symporter GSY53_13475 ENOG4106CAD Protein of unknown function (DUF3311) GSY53_13480 ENOG41060YP GSY53_13495 ENOG4107SCK Monooxygenase GSY53_13500 ENOG4108INS Transcriptional regulator GSY53_13515 ENOG4105TRI Hydrolase GSY53_13530 ENOG4108KK1 membrane protein AbrB duplication GSY53_13535 ENOG4106K7D Major facilitator family transporter GSY53_13545 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding GSY53_13560 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation GSY53_13570 ENOG4105EYH Exonuclease GSY53_13620 ENOG4105ERH Fumarylacetoacetate hydrolase GSY53_13630 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GSY53_13640 ENOG4105CAQ asparagine synthetase GSY53_13655 ENOG4105UQX Mate efflux family protein GSY53_13660 ENOG4106HBX Transcriptional Regulator AraC Family GSY53_13665 ENOG4105ETE Transcriptional regulator (LacI family GSY53_13670 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) GSY53_13675 ENOG4105SF0 DinB family GSY53_13680 ENOG4108ZUB Lysine exporter protein (Lyse ygga) GSY53_13685 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family GSY53_13690 ENOG4105MYW Pentapeptide repeat protein GSY53_13695 ENOG4107S9D Alpha beta hydrolase GSY53_13700 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) GSY53_13705 ENOG4107RIQ Sulfate adenylate transferase GSY53_13710 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GSY53_13715 ENOG4108N5B 2-phosphosulfolactate phosphatase GSY53_13720 ENOG41061P3 phosphosulfolactate synthase GSY53_13730 ENOG4105DIA mandelate racemase muconate lactonizing GSY53_13735 ENOG4107RCC Major Facilitator Superfamily GSY53_13740 ENOG4108SZE gCN5-related N-acetyltransferase GSY53_13745 ENOG4105MA6 gCN5-related N-acetyltransferase GSY53_13755 ENOG4108VPT UPF0234 protein GSY53_13760 ENOG4105QNR S1 RNA binding domain protein GSY53_13780 ENOG4105K7K Transcriptional regulator GSY53_13790 ENOG410751J GSY53_13795 ENOG4105D4Y metalloprotease GSY53_13800 ENOG4105EPR degv family GSY53_13805 ENOG4107AYK membrAne GSY53_13815 ENOG41073B9 GSY53_13820 ENOG4108KP7 hydrolase GSY53_13825 ENOG4108MXZ Esterase GSY53_13830 ENOG4105VG1 fes assembly suf system protein GSY53_13840 ENOG4105IQ5 FAD linked oxidase domain protein GSY53_13850 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase GSY53_13865 ENOG4105C8Y Acetylornithine aminotransferase GSY53_13870 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GSY53_13880 ENOG4105DBV ornithine carbamoyltransferase GSY53_13905 ENOG4107RMD Basic membrane lipoprotein GSY53_13920 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) GSY53_13925 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) GSY53_13935 ENOG4105C3U ABC transporter GSY53_13940 ENOG4108JQ7 (ABC) transporter GSY53_13955 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GSY53_13965 ENOG4105C31 Tryptophanyl-tRNA synthetase GSY53_13970 ENOG4108J59 Extracellular solute-binding protein, family 5 GSY53_13975 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GSY53_13980 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GSY53_13990 ENOG4108JQ7 (ABC) transporter GSY53_14005 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) GSY53_14010 ENOG4108ZCF integral membrane protein GSY53_14020 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis GSY53_14035 ENOG4105DPN Oligoendopeptidase f GSY53_14045 ENOG4105T58 Dithiol-disulfide isomerase GSY53_14050 ENOG4108Z18 K06886 hemoglobin GSY53_14055 ENOG4105E4C Lytic transglycosylase catalytic GSY53_14060 ENOG4105MIX Adenylate cyclase GSY53_14075 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) GSY53_14080 ENOG4105EMS pseudouridine synthase GSY53_14095 ENOG4105ETU transcriptional activator (TenA GSY53_14100 ENOG4108VEU Thiamine monophosphate synthase GSY53_14115 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) GSY53_14120 ENOG4105D06 uba thif-type nad fad binding protein GSY53_14125 ENOG4105DWF phosphomethylpyrimidine kinase GSY53_14130 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH GSY53_14135 ENOG4107A88 GSY53_14185 ENOG4105ENA helicase GSY53_14200 ENOG4108ZMI UPF0477 protein GSY53_14210 ENOG4105C28 cystathionine GSY53_14215 ENOG4105C28 cystathionine GSY53_14220 ENOG4105D9U N-acetyltransferase GSY53_14225 ENOG4105JHY Membrane GSY53_14250 ENOG4106BHF GSY53_14300 ENOG4108PSK reductase GSY53_14315 ENOG4105DM4 PTS System GSY53_14320 ENOG4105DG6 mannose-6-phosphate isomerase GSY53_14325 ENOG4105G7B Protein of unknown function (DUF2992) GSY53_14330 ENOG4105VMI -acetyltransferase GSY53_14340 ENOG4108Z66 YbaK ebsC protein GSY53_14355 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GSY53_14365 ENOG4108ZJ4 polysaccharide deacetylase GSY53_14370 ENOG4107CUJ Protein of unknown function (DUF2690) GSY53_14395 ENOG4108IEG Formate dehydrogenase Alpha subunit GSY53_14420 ENOG4106A3M Cytochrome p-450 GSY53_14425 ENOG41087PP glycosyltransferase MGT family GSY53_14435 ENOG4105EXQ uroporphyrinogen iii synthase hem4 GSY53_14440 ENOG4105C4B ABC transporter, permease GSY53_14445 ENOG4108IXI (ABC) transporter GSY53_14455 ENOG4105Q95 Cupin 2, conserved barrel domain protein GSY53_14470 ENOG4105D2H Uronic isomerase GSY53_14475 ENOG4105CT4 transporter GSY53_14480 ENOG4105DG4 malate L-lactate dehydrogenase GSY53_14485 ENOG4105CPQ Dehydrogenase GSY53_14490 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) GSY53_14495 ENOG4105DMW Dehydrogenase reductase GSY53_14500 ENOG4108I5G Major Facilitator superfamily GSY53_14505 ENOG4107KJX Transcriptional regulator GSY53_14510 ENOG4107QZW Altronate oxidoreductase GSY53_14515 ENOG4105CTX dehydratase GSY53_14520 ENOG4107TSN permease GSY53_14530 ENOG4105JD4 ATPase yjob GSY53_14545 ENOG41068K0 YCII-related domain GSY53_14550 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase GSY53_14555 ENOG4105KWG Pfam:DUF1696 GSY53_14560 ENOG4105K7W phage-related replication protein GSY53_14565 ENOG4105WEF catalase GSY53_14570 ENOG410635T phage-like element pbsx protein GSY53_14615 ENOG4108TFU terminase (Small subunit) GSY53_14620 ENOG4105IG6 Phage terminase, large subunit GSY53_14625 ENOG4108MDF Phage Portal Protein GSY53_14650 ENOG41060SN GSY53_14665 ENOG4105PQS phage protein GSY53_14670 ENOG4105FR7 XkdM protein, phage-like element PBSX GSY53_14675 ENOG4105MTC XkdN-like protein GSY53_14685 ENOG4108FKH Transglycosylase SLT domain GSY53_14690 ENOG4108WZM domain protein GSY53_14695 ENOG4105X7F GSY53_14705 ENOG4105MFU Protein of unknown function (DUF2634) GSY53_14710 ENOG41066EA baseplate J family protein GSY53_14715 ENOG410906S phage-like element pbsx protein xkdt GSY53_14725 ENOG41068G1 GSY53_14755 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GSY53_14775 ENOG4105CJ3 phosphate transporter GSY53_14780 ENOG4107GRR phosphate transport regulator GSY53_14785 ENOG4107R7I amino acid GSY53_14795 ENOG4105EDW glycosyl transferase, family 39 GSY53_14800 ENOG4105CKK Glycosyl transferase, family 2 GSY53_14805 ENOG4105C0H protease GSY53_14815 ENOG4108ME1 Peptidase M55 D-aminopeptidase GSY53_14820 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component GSY53_14825 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component GSY53_14830 ENOG4105C3U ABC transporter GSY53_14840 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A GSY53_14845 ENOG4105DTQ mandelate racemase muconate lactonizing GSY53_14850 ENOG4107SN7 NLP P60 protein GSY53_14855 ENOG4108JQ7 (ABC) transporter GSY53_14860 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) GSY53_14865 ENOG4107TUM Amidinotransferase GSY53_14870 ENOG4108S4H thioesterase Superfamily protein GSY53_14875 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) GSY53_14895 ENOG4108428 Inherit from COG: -acetyltransferase GSY53_14905 ENOG41080TC multidrug resistance protein GSY53_14910 ENOG4105CIY formyltetrahydrofolate deformylase GSY53_14915 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GSY53_14930 ENOG4105K56 Transcriptional regulator GSY53_14935 ENOG4108ZHJ Organic hydroperoxide resistance protein GSY53_14945 ENOG4107Y2X deaminase GSY53_14950 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) GSY53_14955 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GSY53_14965 ENOG4108W7F transporter, permease GSY53_14970 ENOG4108JJB ABC transporter GSY53_14975 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein GSY53_14980 ENOG4108X43 YKOF domain protein GSY53_14985 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GSY53_14990 ENOG41062D9 Histidine kinase GSY53_15000 ENOG4106849 propeptide, pepSY amd peptidase M4 GSY53_15010 ENOG4105CJW magnesium transporter GSY53_15015 ENOG4105V75 Transcriptional regulator GSY53_15060 ENOG4105DQE DNA ligase GSY53_15065 ENOG4105FDF Could be involved in DNA repair (By similarity) GSY53_15070 ENOG4105BZU Histidine kinase GSY53_15075 ENOG4107T5V SNARE associated Golgi GSY53_15080 ENOG4107TS3 membrane protein, TerC GSY53_15085 ENOG4108WZW RNA polymerase sigma GSY53_15095 ENOG410681C small acid-soluble spore protein GSY53_15105 ENOG4105D0M Protease HtpX homolog GSY53_15125 ENOG4108TGC Acyltransferase GSY53_15130 ENOG4105BZU Histidine kinase GSY53_15135 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) GSY53_15145 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) GSY53_15150 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) GSY53_15155 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase GSY53_15165 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit GSY53_15170 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) GSY53_15175 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) GSY53_15180 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) GSY53_15200 ENOG4105BZU Histidine kinase GSY53_15205 ENOG41090MY MarR family Transcriptional regulator GSY53_15210 ENOG4105ER2 Ompa motb domain protein GSY53_15215 ENOG4105E14 MotA TolQ exbB proton channel GSY53_15225 ENOG4108K88 Membrane GSY53_15230 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) GSY53_15235 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase GSY53_15240 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) GSY53_15245 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) GSY53_15255 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr GSY53_15260 ENOG4105FEA Spore maturation protein GSY53_15290 ENOG4105F0V Cell wall hydrolase GSY53_15305 ENOG4105C59 p-type ATPase GSY53_15315 ENOG4105DC7 peptidase M24 GSY53_15325 ENOG4105CID antiterminator GSY53_15335 ENOG4105KRI phosphocarrier protein (HPr GSY53_15340 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) GSY53_15350 ENOG4105F6S Spore photoproduct lyase GSY53_15360 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer GSY53_15365 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase GSY53_15370 ENOG4105K4I Scp-like extracellular GSY53_15380 ENOG4105BZU Histidine kinase GSY53_15385 ENOG4105CHM Aminotransferase GSY53_15395 ENOG4107R88 Chemotaxis protein (CheV) GSY53_15400 ENOG4105UIN GSY53_15410 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein GSY53_15420 ENOG4105K6S Short-chain dehydrogenase reductase Sdr GSY53_15425 ENOG4105ESF Peptidoglycan binding domain protein GSY53_15430 ENOG4105ESF Peptidoglycan binding domain protein GSY53_15440 ENOG4105EPM Diguanylate phosphodiesterase GSY53_15450 ENOG4107IN1 Protein of unknown function (DUF1797) GSY53_15455 ENOG4108XRC Protein of unknown function (DUF458) GSY53_15485 ENOG4105NQC Flavodoxin GSY53_15495 ENOG4105CH2 amidohydrolase GSY53_15505 ENOG4105D8X mechanosensitive ion channel GSY53_15510 ENOG4105D3R alkyl hydroperoxide reductase GSY53_15515 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GSY53_15530 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) GSY53_15535 ENOG4105D06 uba thif-type nad fad binding protein GSY53_15540 ENOG4105CVM Molybdenum cofactor synthesis domain protein GSY53_15545 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein GSY53_15550 ENOG4108ZAF Molybdopterin GSY53_15555 ENOG41067WU Molybdopterin converting factor (Subunit 1) GSY53_15560 ENOG4105BZ1 (ABC) transporter GSY53_15565 ENOG4105BZ1 (ABC) transporter GSY53_15575 ENOG4107X8C Efflux transporter RND family MFP subunit GSY53_15580 ENOG4105C19 ABC transporter GSY53_15585 ENOG4107RBB ABC transporter, permease GSY53_15590 ENOG4105E98 transcriptional regulator DeoR family GSY53_15595 ENOG4105DE4 1-phosphofructokinase GSY53_15600 ENOG4105DM4 PTS System GSY53_15605 ENOG4105C3F Signal peptidase i GSY53_15615 ENOG4105C5H ABC transporter GSY53_15620 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) GSY53_15645 ENOG4105BZU Histidine kinase GSY53_15655 ENOG4107ZYR domain protein GSY53_15665 ENOG4105CN5 Metallo-Beta-Lactamase GSY53_15675 ENOG4108X4Q Hydrolase GSY53_15680 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GSY53_15700 ENOG4105CPP Dehydrogenase, E1 component GSY53_15705 ENOG4105C7S Dehydrogenase GSY53_15710 ENOG4107QN2 dihydrolipoyl dehydrogenase GSY53_15725 ENOG4105CXN decarboxylase GSY53_15730 ENOG4105WBI UPF0223 protein GSY53_15745 ENOG4105ECY inositol monophosphatase GSY53_15755 ENOG4105JQZ Methyltransferase GSY53_15795 ENOG4105CI3 gtp-binding protein typa GSY53_15800 ENOG4105QA2 GSY53_15815 ENOG4108IAB Phoh family GSY53_15825 ENOG4105CSV Glutaminase GSY53_15830 ENOG4105ZPI UPF0358 protein GSY53_15835 ENOG4105CNI cell division protein FtsW GSY53_15840 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) GSY53_15850 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) GSY53_15860 ENOG4105BZ9 Cytochrome C oxidase, subunit I GSY53_15865 ENOG4105CCU oxidase (Subunit III) GSY53_15870 ENOG41064X9 cytochrome C oxidase subunit IV GSY53_15885 ENOG41080XQ Signal transduction protein with cbs domains GSY53_15890 ENOG4106UY4 Inherit from COG: Scp-like extracellular GSY53_15910 ENOG4105WUC UPF0298 protein GSY53_15915 ENOG4106H78 methyltransferase GSY53_15920 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) GSY53_15925 ENOG4105H20 Sporulation integral membrane protein YlbJ GSY53_15930 ENOG4105D78 K07001 NTE family protein GSY53_15935 ENOG41063PX domain protein GSY53_15940 ENOG4105CDE UPF0348 protein GSY53_15950 ENOG4105KNH Nucleic acid-binding protein GSY53_15955 ENOG41067VY 50S ribosomal protein L32 GSY53_15980 ENOG4108V6E Cell division protein mraZ GSY53_15985 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) GSY53_15995 ENOG4105CJN penicillin-binding protein GSY53_16000 ENOG4105CJN penicillin-binding protein GSY53_16005 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) GSY53_16010 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) GSY53_16015 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) GSY53_16020 ENOG4105CNI cell division protein FtsW GSY53_16025 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) GSY53_16030 ENOG4105D4A Cell wall formation (By similarity) GSY53_16035 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) GSY53_16040 ENOG4108R2U division initiation protein GSY53_16050 ENOG4105K67 small basic protein GSY53_16055 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) GSY53_16060 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) GSY53_16070 ENOG4105FFI sigma-e processing peptidase spoiiga GSY53_16075 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GSY53_16085 ENOG4105DKW ABC transporter GSY53_16095 ENOG4105WR5 sporulation protein, YlmC YmxH family GSY53_16100 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase GSY53_16105 ENOG4105DFA alanine racemase domain protein GSY53_16110 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) GSY53_16115 ENOG41067XK integral membrane protein GSY53_16120 ENOG4105DBK s4 domain protein GSY53_16130 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) GSY53_16140 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) GSY53_16145 ENOG4105C34 Pseudouridine synthase GSY53_16150 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) GSY53_16160 ENOG4105CXT aspartate transcarbamylase GSY53_16170 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain GSY53_16175 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain GSY53_16180 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) GSY53_16185 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) GSY53_16190 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) GSY53_16195 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) GSY53_16200 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) GSY53_16210 ENOG4107S4M Sulfate adenylate transferase GSY53_16215 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) GSY53_16220 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) GSY53_16225 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein GSY53_16230 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein GSY53_16235 ENOG4105F23 Fibronectin-binding protein GSY53_16245 ENOG4105DSJ YicC domain protein GSY53_16250 ENOG4105KC4 UPF0296 protein GSY53_16255 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) GSY53_16265 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase GSY53_16270 ENOG4105C25 Primosomal protein n' GSY53_16275 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) GSY53_16280 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) GSY53_16285 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B GSY53_16290 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs GSY53_16295 ENOG4108ZF3 Phosphatase GSY53_16300 ENOG4105D9P serine threonine protein kinase GSY53_16305 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) GSY53_16310 ENOG4105DJV ribulose-phosphate 3-epimerase GSY53_16315 ENOG4105FJ0 thiamine GSY53_16325 ENOG4105VB9 50S ribosomal protein l28 GSY53_16330 ENOG4108ZAA Alkaline-shock protein GSY53_16335 ENOG4105DP4 dak2 domain fusion protein ylov GSY53_16345 ENOG4105EJQ L-serine dehydratase GSY53_16350 ENOG4105CB5 ATP-dependent DNA helicase recG GSY53_16355 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) GSY53_16365 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GSY53_16370 ENOG4105CHR reductase GSY53_16375 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) GSY53_16380 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) GSY53_16385 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) GSY53_16390 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) GSY53_16400 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) GSY53_16410 ENOG4105K5M 30s ribosomal protein S16 GSY53_16415 ENOG4108BW8 UPF0109 protein GSY53_16425 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) GSY53_16430 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) GSY53_16435 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) GSY53_16440 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) GSY53_16445 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) GSY53_16455 ENOG4105VM1 flagellar GSY53_16460 ENOG4105CMV Succinyl-CoA synthetase subunit beta GSY53_16465 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha GSY53_16470 ENOG4105C79 DNA protecting protein DprA GSY53_16475 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) GSY53_16480 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) GSY53_16485 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GSY53_16490 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) GSY53_16495 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) GSY53_16505 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) GSY53_16510 ENOG4108ZC9 flagellar basal-body rod protein flgc GSY53_16515 ENOG4105VQ0 flagellar hook-basal body complex protein fliE GSY53_16520 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) GSY53_16525 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GSY53_16540 ENOG4106YF4 Flagellar biosynthesis chaperone GSY53_16550 ENOG410696Y Flagellar hook-length control protein GSY53_16555 ENOG410822I Flagellar hook capping protein GSY53_16560 ENOG4108JQA flagellar GSY53_16565 ENOG41068WV flagellar FlbD family protein GSY53_16575 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) GSY53_16580 ENOG4105DD5 Flagellar motor switch protein GSY53_16585 ENOG4107YTP response regulator receiver protein GSY53_16595 ENOG4105CN7 Flagellar biosynthetic protein FliP GSY53_16600 ENOG4105VS8 Flagellar biosynthetic protein fliq GSY53_16605 ENOG4105D19 Role in flagellar biosynthesis (By similarity) GSY53_16610 ENOG4105D00 flagellar biosynthetic protein flhB GSY53_16615 ENOG4105D7B Flagellar biosynthesis protein flha GSY53_16620 ENOG4105FZW flagellar biosynthesis regulator FlhF GSY53_16630 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) GSY53_16635 ENOG4105CBS Chea signal transduction histidine kinase GSY53_16640 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis GSY53_16655 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GSY53_16665 ENOG4105CE9 30S ribosomal protein S2 GSY53_16670 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) GSY53_16680 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) GSY53_16685 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) GSY53_16690 ENOG4105KNE Phosphatidate cytidylyltransferase GSY53_16700 ENOG4105DZP Membrane-associated zinc metalloprotease GSY53_16705 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) GSY53_16710 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) GSY53_16715 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) GSY53_16720 ENOG4105CHV Transcription elongation factor NusA GSY53_16725 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination GSY53_16730 ENOG4105VHM ribosomal protein GSY53_16735 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) GSY53_16740 ENOG4105W7A Protein of unknown function (DUF503) GSY53_16745 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) GSY53_16750 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) GSY53_16755 ENOG4105DTN riboflavin biosynthesis protein ribF GSY53_16760 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) GSY53_16765 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) GSY53_16775 ENOG4105C1V Peptidase, M16 GSY53_16785 ENOG4105E35 Dipicolinate synthase subunit A GSY53_16790 ENOG4108S0H Dipicolinic acid synthetase, b subunit GSY53_16795 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) GSY53_16805 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) GSY53_16815 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit GSY53_16825 ENOG4105CNU cell division protein FtsK GSY53_16830 ENOG4105FDP GntR family transcriptional regulator GSY53_16850 ENOG4108RKS Short-chain dehydrogenase reductase Sdr GSY53_16855 ENOG4105XZV Protein of unknown function (DUF3243) GSY53_16870 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase GSY53_16875 ENOG4105CEV competence damage-inducible protein GSY53_16885 ENOG4108A04 Beta-lactamase GSY53_16890 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) GSY53_16895 ENOG4105D48 metallophosphoesterase GSY53_16900 ENOG4105MCT stage V sporulation protein S GSY53_16910 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) GSY53_16915 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GSY53_16930 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) GSY53_16935 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) GSY53_16945 ENOG4105IIP Membrane GSY53_16950 ENOG4105W1N transcriptional regulator GSY53_16955 ENOG4108151 Beta-lactamase domain protein GSY53_16965 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase GSY53_16975 ENOG4107QKG PfaD family GSY53_16980 ENOG41062T2 Acyl carrier protein GSY53_16985 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase GSY53_16990 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase GSY53_16995 ENOG4108MGH Enoyl-CoA hydratase GSY53_17000 ENOG4108KQ6 Enoyl-CoA hydratase GSY53_17005 ENOG4105C0W non-ribosomal peptide synthetase GSY53_17010 ENOG4107SQU synthase GSY53_17020 ENOG4105C0W non-ribosomal peptide synthetase GSY53_17030 ENOG4106A3M Cytochrome p-450 GSY53_17045 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin GSY53_17055 ENOG4105K7W phage-related replication protein GSY53_17060 ENOG4108X3M OsmC Ohr family protein GSY53_17065 ENOG410814C multidrug resistance protein GSY53_17085 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) GSY53_17090 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) GSY53_17105 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) GSY53_17110 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GSY53_17115 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) GSY53_17120 ENOG4105U6W MutT NUDIX family protein GSY53_17125 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GSY53_17130 ENOG4106F1P AAA ATPase, central domain protein GSY53_17135 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) GSY53_17140 ENOG4105CXI aluminum resistance protein GSY53_17145 ENOG4105KV4 Transcriptional regulator GSY53_17150 ENOG4105C5F glutamine synthetase GSY53_17325 ENOG4108FKH Transglycosylase SLT domain GSY53_17335 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj GSY53_17370 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase GSY53_17375 ENOG4106ANW SMI1_KNR4 GSY53_17380 ENOG4106BHF GSY53_17385 ENOG410780I phosphoprotein phosphatase activity GSY53_17390 ENOG41079P0 GSY53_17410 ENOG4107AUC GSY53_17445 ENOG410907G GSY53_17450 ENOG4105CT4 transporter GSY53_17455 ENOG4105DSG hydrolase family 43 GSY53_17460 ENOG4105E2R ROK family GSY53_17465 ENOG4105C93 Xylose Isomerase GSY53_17470 ENOG4105CMG Carbohydrate kinase GSY53_17480 ENOG4107Y9E nuclease GSY53_17485 ENOG4105C54 Major Facilitator superfamily GSY53_17490 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) GSY53_17500 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) GSY53_17570 ENOG4108Q8B Spore germination protein GSY53_17575 ENOG4108NHD germination protein GSY53_17590 ENOG4105FVX GSY53_17600 ENOG4105K7W phage-related replication protein GSY53_17610 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) GSY53_17615 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) GSY53_17625 ENOG4108SVB resolvase GSY53_17630 ENOG4105VPS UPF0291 protein GSY53_17635 ENOG4105CV1 Transketolase (EC 2.2.1.1) GSY53_17655 ENOG4107QIV Cytochrome c biogenesis protein GSY53_17680 ENOG4107DZX Small, acid-soluble spore protein P GSY53_17690 ENOG4108I0Z Aconitate hydratase GSY53_17695 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen GSY53_17710 ENOG41067CD Small, acid-soluble spore protein Tlp GSY53_17720 ENOG4105MI2 GSY53_17725 ENOG4105W8X HesB YadR YfhF-family protein GSY53_17730 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) GSY53_17735 ENOG4105K4P CoA-binding domain protein GSY53_17740 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) GSY53_17760 ENOG4107QWR cellulase (EC 3.2.1.4) GSY53_17770 ENOG4108MYR Secreted protein GSY53_17775 ENOG4107SYN Glycosyl hydrolases family 43 GSY53_17785 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase GSY53_17790 ENOG4107T5V SNARE associated Golgi GSY53_17800 ENOG4107QX3 carboxylase GSY53_17805 ENOG4105E39 Enoyl-CoA hydratase GSY53_17810 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase GSY53_17815 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit GSY53_17820 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GSY53_17825 ENOG4105CEY Amp-dependent synthetase and ligase GSY53_17830 ENOG4105C1G acyl-Coa dehydrogenase GSY53_17845 ENOG4105F32 YngK protein GSY53_17850 ENOG4106U2H Protein of unknown function (DUF1360) GSY53_17860 ENOG4105CEY Amp-dependent synthetase and ligase GSY53_17865 ENOG4105C0W non-ribosomal peptide synthetase GSY53_17875 ENOG4105C0W non-ribosomal peptide synthetase GSY53_17880 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family GSY53_17885 ENOG4108N2V aldose 1-epimerase GSY53_17890 ENOG4107QJQ Mate efflux family protein GSY53_17915 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) GSY53_17920 ENOG4105SKE transcriptional Regulator LysR family GSY53_17925 ENOG4105CB2 alcohol dehydrogenase GSY53_17930 ENOG4105BZ8 glutamate synthase GSY53_17935 ENOG4105CBC glutamate synthase GSY53_17940 ENOG4105C5Q Transcriptional regulator GSY53_17945 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) GSY53_17950 ENOG4105II7 pyrroline-5-carboxylate reductase GSY53_17970 ENOG4108UB7 GSY53_17975 ENOG41068WN GSY53_17980 ENOG4105IE8 Alpha-ketoglutarate permease GSY53_17985 ENOG4107U6E carbohydrate kinase FGGY GSY53_17990 ENOG4108M3J Dehydrogenase GSY53_17995 ENOG4108J2R molybdopterin oxidoreductase GSY53_18025 ENOG4105EC8 Methyl-accepting chemotaxis GSY53_18035 ENOG4108YQE rare lipoprotein a GSY53_18040 ENOG4105XPP Protein of unknown function (DUF1275) GSY53_18045 ENOG4108NR7 pectate lyase GSY53_18050 ENOG4108RAV Conserved protein GSY53_18060 ENOG4105F0F Oxalate decarboxylase GSY53_18075 ENOG4105EPI acetyltransferase, (GNAT) family GSY53_18095 ENOG41073R8 VanW family GSY53_18105 ENOG4105VMP Transcriptional regulator GSY53_18110 ENOG4105NX3 Membrane GSY53_18120 ENOG4108Q5Y Membrane GSY53_18130 ENOG4108V4B ThiJ pfpI GSY53_18135 ENOG4108J4B Beta-lactamase GSY53_18160 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) GSY53_18165 ENOG4107T94 Endo-14-beta-xylanase GSY53_18170 ENOG4105YB8 TM2 domain containing protein GSY53_18175 ENOG4108IMY Transcriptional regulator GSY53_18190 ENOG4108RAV Conserved protein GSY53_18195 ENOG41079CX GSY53_18225 ENOG410780I phosphoprotein phosphatase activity GSY53_18250 ENOG4105DB4 GSY53_18270 ENOG4106ANW SMI1_KNR4 GSY53_18275 ENOG4106BHF GSY53_18295 ENOG4108Z7R Chaperone CsaA GSY53_18300 ENOG4105FTV AraC Family Transcriptional Regulator GSY53_18305 ENOG4108HJF gCN5-related N-acetyltransferase GSY53_18315 ENOG4108W8B Beta-lactamase domain protein GSY53_18325 ENOG4105D29 Helix-turn-helix type 11 domain protein GSY53_18335 ENOG4105KTU Transcriptional regulator, arsr family GSY53_18345 ENOG4108SJC Membrane GSY53_18365 ENOG4105ECK Fatty Acid Desaturase GSY53_18370 ENOG4108ZGX Histidine kinase GSY53_18375 ENOG4108S01 response regulator GSY53_18380 ENOG41069ER domain protein GSY53_18385 ENOG4105C9U ATP-dependent DNA helicase RecQ GSY53_18395 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) GSY53_18400 ENOG4105SCY DNAK suppressor GSY53_18440 ENOG4105C26 Dehydrogenase GSY53_18445 ENOG4105EWU Squalene--hopene cyclase GSY53_18450 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GSY53_18455 ENOG4105C8J )-transporter GSY53_18460 ENOG4105C09 Bile acid GSY53_18465 ENOG4105C7S Dehydrogenase GSY53_18475 ENOG4107T89 von Willebrand factor, type A GSY53_18480 ENOG4105GMT ATPase associated with various cellular activities aaa_5 GSY53_18490 ENOG4105K4H Nlp p60 protein GSY53_18495 ENOG41087PP glycosyltransferase MGT family GSY53_18505 ENOG4107QMU Mate efflux family protein GSY53_18510 ENOG4106SCS STAS domain GSY53_18530 ENOG4105FR1 rard protein GSY53_18545 ENOG4105C6Z Gluconate GSY53_18550 ENOG41090U3 tautomerase GSY53_18565 ENOG4105FBA Phospholipase Carboxylesterase GSY53_18580 ENOG4105E1V na solute symporter GSY53_18600 ENOG4108VXD carboxy-peptidase GSY53_18605 ENOG4105D3A purine nucleoside phosphorylase DeoD-type GSY53_18615 ENOG4106Z5R GSY53_18620 ENOG410841Q phosphoesterase PA-phosphatase related protein GSY53_18650 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein GSY53_18655 ENOG4108TSC N-acetyltransferase GSY53_18660 ENOG4107S4Y M20 DapE family protein YgeY GSY53_18675 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) GSY53_18715 ENOG4107T32 3-phytase (EC 3.1.3.8) GSY53_18720 ENOG4105C5E polysaccharide biosynthesis protein GSY53_18725 ENOG4105E0X reductase GSY53_18730 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) GSY53_18750 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) GSY53_18755 ENOG41090WU lipolytic protein G-D-S-L family GSY53_18760 ENOG4108KF3 Electron transport protein SCO1 SenC GSY53_18770 ENOG4105C7B Threonine dehydratase GSY53_18780 ENOG4108UT2 hemolysin iii GSY53_18790 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) GSY53_18795 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) GSY53_18810 ENOG4107YX5 Pfam:DUF548 GSY53_18815 ENOG4108Y6J UPF0403 protein GSY53_18820 ENOG4105C01 Dihydroxy-acid dehydratase GSY53_18835 ENOG4108V06 Glutathione peroxidase GSY53_18840 ENOG4105CVG Homoserine O-transsuccinylase GSY53_18885 ENOG41081VK Ribonuclease GSY53_18910 ENOG410890F Dynamin family GSY53_18925 ENOG41065KQ synthase GSY53_18930 ENOG4105C2W permease GSY53_18935 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) GSY53_18940 ENOG4105CTD carboxy-peptidase GSY53_18945 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) GSY53_18950 ENOG4108UHU Aldolase GSY53_18955 ENOG4105D7K pfkb domain protein GSY53_18960 ENOG4108M60 Transcriptional regulator GSY53_18970 ENOG4105CHR reductase GSY53_18975 ENOG4105DVT helicase GSY53_18990 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) GSY53_19005 ENOG4108UKS UPF0398 protein GSY53_19020 ENOG4107X2U Inherit from COG: Exonuclease-like protein GSY53_19025 ENOG4108I5C dEAD DEAH box helicase GSY53_19075 ENOG4105BZ4 penicillin-binding protein GSY53_19085 ENOG4105CSM endonuclease III GSY53_19095 ENOG4105C5S asparaginyl-tRNA synthetase GSY53_19100 ENOG4105CHM Aminotransferase GSY53_19110 ENOG4105YAC GSY53_19115 ENOG4105DVT helicase GSY53_19120 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) GSY53_19125 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) GSY53_19130 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) GSY53_19135 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase GSY53_19140 ENOG4105DJ0 Poly(A) Polymerase GSY53_19145 ENOG4105CPK Glycosyl transferase (Group 1 GSY53_19150 ENOG4105FJR Lmbe family GSY53_19155 ENOG4108Z5K methylglyoxal synthase GSY53_19160 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) GSY53_19165 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase GSY53_19170 ENOG4108JYZ YitT family GSY53_19190 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) GSY53_19210 ENOG41068YB TPR repeat-containing protein GSY53_19215 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase GSY53_19225 ENOG4105CIH Imidazole acetol-phosphate transaminase GSY53_19235 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) GSY53_19240 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase GSY53_19250 ENOG4108I0Q anthranilate phosphoribosyltransferase GSY53_19255 ENOG4105CRQ synthase (Component I) GSY53_19260 ENOG4105KHN chorismate mutase GSY53_19265 ENOG4105D49 3-dehydroquinate synthase GSY53_19270 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase GSY53_19275 ENOG4105BZU Histidine kinase GSY53_19280 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) GSY53_19285 ENOG4105EAH synthase GSY53_19290 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) GSY53_19295 ENOG4105XXQ heptaprenyl diphosphate synthase component I GSY53_19305 ENOG4105EUJ GTP cyclohydrolase i GSY53_19310 ENOG4105K70 DNA-binding protein GSY53_19315 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) GSY53_19330 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase GSY53_19335 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) GSY53_19340 ENOG41065D1 GSY53_19345 ENOG4105S2F GSY53_19360 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) GSY53_19365 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) GSY53_19370 ENOG4105CAT Cytidine monophosphate kinase GSY53_19385 ENOG4105MSI germination protein ypeb GSY53_19395 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) GSY53_19400 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase GSY53_19415 ENOG4107RGJ metallophosphoesterase GSY53_19430 ENOG4105I7S Abortive infection protein GSY53_19435 ENOG4105C9U ATP-dependent DNA helicase RecQ GSY53_19440 ENOG4105T7X GSY53_19450 ENOG4108SAX Membrane GSY53_19455 ENOG4108JQ1 Dehydrogenase GSY53_19460 ENOG4105FF2 Type I DHQase GSY53_19475 ENOG4105BZU Histidine kinase GSY53_19480 ENOG4105CK6 Two component transcriptional regulator (Winged helix family GSY53_19485 ENOG4105CRE cytochrome C GSY53_19490 ENOG4107TWT Cytochrome c biogenesis protein GSY53_19500 ENOG4105FE9 pseudouridine synthase GSY53_19510 ENOG4108JIC nucleoside recognition domain protein GSY53_19515 ENOG4105DZ1 carboxypeptidase GSY53_19525 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) GSY53_19530 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) GSY53_19545 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) GSY53_19550 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) GSY53_19555 ENOG4108R6K riboflavin synthase, subunit alpha GSY53_19560 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) GSY53_19570 ENOG4105C3F Signal peptidase i GSY53_19580 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) GSY53_19600 ENOG4107ZE5 PPIases accelerate the folding of proteins GSY53_19605 ENOG4105PTM secreted protein GSY53_19610 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) GSY53_19620 ENOG4105G6R Stage v sporulation protein ae GSY53_19630 ENOG4105CZ3 stage V sporulation protein ad GSY53_19635 ENOG41090VF Stage v sporulation protein ac GSY53_19650 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GSY53_19655 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) GSY53_19660 ENOG41082AN stage II sporulation protein GSY53_19665 ENOG4105DZ1 carboxypeptidase GSY53_19670 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) GSY53_19675 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) GSY53_19680 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) GSY53_19690 ENOG4105I3K Ferric uptake regulator, Fur family GSY53_19695 ENOG4105MZ9 stage II sporulation protein m GSY53_19710 ENOG4105DFD Na H antiporter GSY53_19715 ENOG4108IJ0 Aspartate ammonia-lyase GSY53_19720 ENOG4105HDK L-asparaginase GSY53_19725 ENOG4108IMY Transcriptional regulator GSY53_19735 ENOG4108YZ4 nudix hydrolase GSY53_19745 ENOG4105CPC Aldo Keto reductase GSY53_19765 ENOG4106HZJ GSY53_19770 ENOG4105RHY Pfam:UPF0157 GSY53_19775 ENOG4105KAC Antibiotic biosynthesis monooxygenase GSY53_19780 ENOG4108XET gCN5-related N-acetyltransferase GSY53_19790 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GSY53_19800 ENOG4105E5W Transporter GSY53_19805 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase GSY53_19820 ENOG4108IXY short-chain dehydrogenase reductase GSY53_19825 ENOG41069FQ Metallo-beta-lactamase superfamily GSY53_19830 ENOG4105II7 pyrroline-5-carboxylate reductase GSY53_19840 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GSY53_19850 ENOG410861F 50S ribosomal protein L33 GSY53_19855 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) GSY53_19860 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase GSY53_19865 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) GSY53_19870 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) GSY53_19880 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) GSY53_19885 ENOG4108NA0 Uncharacterized conserved protein (COG2071) GSY53_19890 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) GSY53_19895 ENOG4108HNZ carboxyl transferase GSY53_19900 ENOG4108ZVT methylmalonyl-coA epimerase GSY53_19910 ENOG4108VZI ErfK ybiS ycfS ynhG family protein GSY53_19915 ENOG4108QEG Membrane GSY53_19920 ENOG4105CDA abc transporter atp-binding protein GSY53_19925 ENOG4105E5Q amino acid AbC transporter GSY53_19930 ENOG4108HW3 (ABC) transporter GSY53_19935 ENOG4108Y6J UPF0403 protein GSY53_19940 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) GSY53_19955 ENOG4105C7S Dehydrogenase GSY53_19960 ENOG4105CPP Dehydrogenase, E1 component GSY53_19975 ENOG4105CKM Branched-chain carboxylic acid kinase GSY53_19980 ENOG4107RDP Dehydrogenase GSY53_19990 ENOG4108JUB Transcriptional regulator GSY53_19995 ENOG4106CCJ Protein of unknown function (DUF2627) GSY53_20000 ENOG4105CR4 methylisocitrate lyase GSY53_20005 ENOG4105DXD 2-methylcitrate dehydratase GSY53_20015 ENOG4105C1G acyl-Coa dehydrogenase GSY53_20020 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase GSY53_20030 ENOG4108QXE glycerophosphoryl diester phosphodiesterase GSY53_20035 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase GSY53_20050 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase GSY53_20055 ENOG4107QQR Sporulation GSY53_20060 ENOG4105S1Z Stage IV sporulation protein B GSY53_20065 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) GSY53_20070 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) GSY53_20075 ENOG4105DX0 Hemolysin A GSY53_20085 ENOG4105CTB Polyprenyl synthetase GSY53_20090 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GSY53_20095 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) GSY53_20100 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) GSY53_20105 ENOG4105M7K Involved in the transcription termination process (By similarity) GSY53_20110 ENOG4108ZSR alkaline shock protein GSY53_20115 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase GSY53_20135 ENOG410644B Stage III sporulation protein af GSY53_20145 ENOG4105KQ4 Stage iii sporulation protein ad GSY53_20150 ENOG4108CQH stage III sporulation protein AC GSY53_20155 ENOG4105KR5 Stage iii sporulation protein GSY53_20160 ENOG4105CD2 stage iii sporulation protein aa GSY53_20170 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) GSY53_20175 ENOG4105DC7 peptidase M24 GSY53_20180 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) GSY53_20190 ENOG4105CBJ Metal-dependent enzyme GSY53_20205 ENOG4105KST dependent repressor GSY53_20210 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) GSY53_20215 ENOG4105WZW rhodanese family GSY53_20220 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GSY53_20225 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor GSY53_20230 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) GSY53_20235 ENOG4105C0D helicase GSY53_20250 ENOG4108IMY Transcriptional regulator GSY53_20260 ENOG4105VFR signal peptidase GSY53_20325 ENOG4105C37 (CBS) domain GSY53_20350 ENOG4105C5X domain protein GSY53_20375 ENOG4105E0M Sulfatase GSY53_20390 ENOG4107ZXI Rhomboid family GSY53_20400 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase GSY53_20405 ENOG4105WDJ 50S ribosomal protein L33 GSY53_20425 ENOG41068DG YceG-like family GSY53_20430 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GSY53_20435 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) GSY53_20440 ENOG4105E2Z phosphate ABC transporter (Permease GSY53_20445 ENOG4105C8U phosphate abc transporter GSY53_20450 ENOG4105CVA phosphate GSY53_20455 ENOG4107RF6 penicillin-binding protein GSY53_20465 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) GSY53_20470 ENOG4105SXS Protein of unknown function (DUF456) GSY53_20490 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) GSY53_20495 ENOG41063Y9 GSY53_20500 ENOG4108U5J '-nucleotidase GSY53_20505 ENOG4105N80 Ferric uptake regulator, Fur family GSY53_20510 ENOG4108JYZ YitT family GSY53_20515 ENOG41069ZM Protein of unknown function (DUF2624) GSY53_20520 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) GSY53_20535 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) GSY53_20540 ENOG4105EGD dinuclear metal center protein, YbgI family GSY53_20555 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) GSY53_20560 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) GSY53_20565 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 GSY53_20570 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) GSY53_20580 ENOG4105C38 Glycyl-tRNA synthetase beta subunit GSY53_20585 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit GSY53_20590 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) GSY53_20600 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) GSY53_20605 ENOG4105KG3 cytidine deaminase GSY53_20610 ENOG4107YR5 Diacylglycerol kinase GSY53_20615 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) GSY53_20620 ENOG4105CTJ Metal Dependent Phosphohydrolase GSY53_20625 ENOG4105C9A Phoh family GSY53_20630 ENOG4105EI1 sporulation protein yqfd GSY53_20635 ENOG41068P3 sporulation protein YqfC GSY53_20645 ENOG4105DI5 UPF0365 protein GSY53_20650 ENOG4105F7J membrane-bound serine protease GSY53_20655 ENOG4105KTH gatB Yqey GSY53_20670 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) GSY53_20675 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) GSY53_20680 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) GSY53_20690 ENOG4105CFG Acts as a chaperone (By similarity) GSY53_20695 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ GSY53_20700 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) GSY53_20705 ENOG4105CSA Coproporphyrinogen iii oxidase GSY53_20710 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) GSY53_20720 ENOG4108ZRV stage ii sporulation protein p GSY53_20725 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) GSY53_20730 ENOG41082YS Binds directly to 16S ribosomal RNA GSY53_20735 ENOG4105TQK DNA polymerase iii, delta' subunit GSY53_20750 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 GSY53_20755 ENOG4108UK2 deaminase GSY53_20760 ENOG4105KQC Competence protein GSY53_20770 ENOG4108D32 Methyltransferase GSY53_20780 ENOG4108WF2 Metal Dependent Phosphohydrolase GSY53_20785 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) GSY53_20790 ENOG410812S Rna-binding protein GSY53_20795 ENOG4105E2X shikimate dehydrogenase GSY53_20800 ENOG4105CQW ribosome biogenesis GTPase YqeH GSY53_20805 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase GSY53_20820 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase GSY53_20825 ENOG41080BT SNARE associated Golgi GSY53_20840 ENOG4105WFK nuclease GSY53_20850 ENOG4107Y5K Resolvase GSY53_20855 ENOG4108UXE Protein tyrosine phosphatase GSY53_20860 ENOG4105D6J arsenicaL-resistance protein GSY53_20865 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase GSY53_20870 ENOG41085FC arsR family transcriptional regulator GSY53_20900 ENOG41064HX Suppressor of fused protein (SUFU) GSY53_20920 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase GSY53_20955 ENOG410906S phage-like element pbsx protein xkdt GSY53_20960 ENOG41066EA baseplate J family protein GSY53_20965 ENOG4105MFU Protein of unknown function (DUF2634) GSY53_20975 ENOG4105X7F GSY53_20980 ENOG4108WZM domain protein GSY53_20985 ENOG4108FKH Transglycosylase SLT domain GSY53_20995 ENOG4105MTC XkdN-like protein GSY53_21010 ENOG4105FR7 XkdM protein, phage-like element PBSX GSY53_21015 ENOG4105PQS phage protein GSY53_21030 ENOG41060SN GSY53_21065 ENOG4106CGH Phage Mu protein F like protein GSY53_21070 ENOG4108MDF Phage Portal Protein GSY53_21075 ENOG4105IG6 Phage terminase, large subunit GSY53_21095 ENOG4106129 GSY53_21105 ENOG4105QBX endodeoxyribonuclease RusA GSY53_21125 ENOG4108PNI recT protein GSY53_21130 ENOG4108NF7 phage-type endonuclease GSY53_21160 ENOG4106A7E Transcriptional regulator GSY53_21165 ENOG41067QW Transcriptional regulator GSY53_21175 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) GSY53_21185 ENOG4107Y5K Resolvase GSY53_21190 ENOG4108UXE Protein tyrosine phosphatase GSY53_21195 ENOG4105D6J arsenicaL-resistance protein GSY53_21200 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase GSY53_21205 ENOG41085FC arsR family transcriptional regulator