locus-tag class description C3496_00010 ENOG41076HS cation diffusion facilitator family transporter C3496_00015 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C3496_00025 ENOG4105CKP Polysaccharide Biosynthesis Protein C3496_00030 ENOG4108QG2 Membrane C3496_00040 ENOG4105VIE preprotein translocase, subunit YajC C3496_00055 ENOG41061AI Protein of unknown function (DUF2905) C3496_00070 ENOG4108HUF Transporter C3496_00080 ENOG4108IPJ Membrane C3496_00085 ENOG41082BM Transcriptional regulator, arsr family C3496_00110 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase C3496_00115 ENOG4108IYU L-aspartate oxidase C3496_00130 ENOG4108RPX mosc domain containing protein C3496_00135 ENOG4105CQC Prephenate dehydratase C3496_00155 ENOG4105EWM Histidine kinase C3496_00180 ENOG4105X36 (ribosomal) protein C3496_00190 ENOG4105C03 ribonuclease C3496_00205 ENOG4107QMS site-determining protein C3496_00220 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) C3496_00225 ENOG4105DFF Rod shape-determining protein mreb C3496_00250 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase C3496_00255 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) C3496_00265 ENOG41068KH stage VI sporulation protein D C3496_00275 ENOG4105D52 delta-aminolevulinic acid dehydratase C3496_00300 ENOG4105K56 Transcriptional regulator C3496_00320 ENOG4108IUQ atp-dependent protease C3496_00350 ENOG4108QCI YvbH-like oligomerisation region C3496_00370 ENOG4105M59 Phosphodiesterase, mj0936 family C3496_00385 ENOG4108XJQ germination protein C3496_00395 ENOG4108PCX Major Facilitator C3496_00405 ENOG4105KBX Transcriptional regulator, TetR family C3496_00420 ENOG4105PFC Transcriptional regulator C3496_00455 ENOG41082YX Transcriptional regulator, arsr family C3496_00465 ENOG4105D6J arsenicaL-resistance protein C3496_00480 ENOG4105DSE periplasmic solute binding protein C3496_00485 ENOG4105CC5 ABC transporter C3496_00490 ENOG4105DIK (ABC) transporter C3496_00505 ENOG4108KF3 Electron transport protein SCO1 SenC C3496_00510 ENOG4107ZQN disulfide bond C3496_00545 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) C3496_00560 ENOG4105PFC Transcriptional regulator C3496_00570 ENOG4105DZC cytosine deaminase C3496_00580 ENOG4108JCI Transcriptional regulator C3496_00590 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) C3496_00595 ENOG4108Z40 Transcriptional regulator C3496_00600 ENOG4105RHA ABC transporter, permease C3496_00605 ENOG4108IUX (ABC) transporter C3496_00610 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family C3496_00615 ENOG4105ER2 Ompa motb domain protein C3496_00620 ENOG4105E14 MotA TolQ exbB proton channel C3496_00625 ENOG4108VXD carboxy-peptidase C3496_00635 ENOG4105E33 succinate dehydrogenase C3496_00645 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit C3496_00660 ENOG4105K63 Thioredoxin C3496_00665 ENOG4105C10 Electron transfer flavoprotein C3496_00670 ENOG4105BZJ Electron transfer flavoprotein C3496_00675 ENOG41060WC Enoyl-CoA hydratase C3496_00680 ENOG4107Z3H Transcriptional regulator, TetR family C3496_00685 ENOG4105CEY Amp-dependent synthetase and ligase C3496_00730 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C3496_00745 ENOG4105DR4 Methyltransferase C3496_00760 ENOG4105KFN sortase, SrtB family C3496_00765 ENOG4105E0A ABC, transporter C3496_00780 ENOG4106ST0 Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity) C3496_00785 ENOG4105SGM Involved in heme (porphyrin) scavenging. Binds hemoglobin and almost exclusively free-base protoporphyrin IX. Probably has a role as the central conduit of the isd heme uptake system, i.e. mediates the transfer of the iron-containing nutrient from IsdABH to the membrane translocation system IsdDEF. Hemin- free IsdC (apo-IsdC) acquires hemin from hemin-containing IsdA (holo-IsdA) probably through the activated holo-IsdA-apo-IsdC complex and due to the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity) C3496_00795 ENOG4105FE9 pseudouridine synthase C3496_00810 ENOG4105DCG PHP domain protein C3496_00845 ENOG4105C5S asparaginyl-tRNA synthetase C3496_00855 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) C3496_00865 ENOG4108RWN rrna methyltransferase C3496_00885 ENOG4105C0R drug resistance transporter emrb qaca subfamily C3496_00890 ENOG4105CW7 secretion protein, HlyD family C3496_00895 ENOG4108JGH Tetr family transcriptional regulator C3496_00900 ENOG4105CN9 Peptidase m42 family protein C3496_00920 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) C3496_00925 ENOG4105C22 threonyL-tRNA synthetase C3496_00930 ENOG4108TDW sporulation protein YtxC C3496_00950 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) C3496_00960 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C3496_00965 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) C3496_00975 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) C3496_00980 ENOG4105C2M dna polymerase I C3496_00985 ENOG4105BZU Histidine kinase C3496_00990 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C3496_01015 ENOG4108HMX isocitrate dehydrogenase (NADP) C3496_01020 ENOG4105BZN citrate synthase C3496_01035 ENOG4108REF Sporulation integral membrane protein ytvi C3496_01040 ENOG4105FS0 cytoplasmic membrane protein C3496_01065 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family C3496_01070 ENOG4105C6K Malic enzyme C3496_01075 ENOG4105C0B DNA polymerase III (alpha subunit) C3496_01080 ENOG4105VV2 C3496_01090 ENOG4105SFS phosphoesterase RecJ domain protein C3496_01130 ENOG4105DC7 peptidase M24 C3496_01175 ENOG41082W1 Cupin 2, conserved barrel domain protein C3496_01185 ENOG4105VZ8 Transcriptional regulator C3496_01205 ENOG4107YZX Universal stress protein C3496_01260 ENOG4108JYZ YitT family C3496_01275 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) C3496_01285 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) C3496_01290 ENOG4105KBJ sporulation protein ytfj C3496_01305 ENOG4105EFZ amidohydrolase C3496_01315 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C3496_01340 ENOG4106KR7 LysR family Transcriptional regulator C3496_01350 ENOG4105U5Y Transcriptional regulator C3496_01360 ENOG4105C28 cystathionine C3496_01385 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C3496_01395 ENOG4105EMN RNA polymerase sigma factor C3496_01410 ENOG4105F1V Acetoin utilization protein C3496_01415 ENOG4105W87 Cbs domain C3496_01420 ENOG4105DGU Histone deacetylase C3496_01435 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C3496_01445 ENOG4107SNB ankyrin repeat protein YahD C3496_01450 ENOG4105EP9 oxidoreductase C3496_01480 ENOG4105ETE Transcriptional regulator (LacI family C3496_01510 ENOG4105C88 aminopeptidase C3496_01570 ENOG4108VDD TRNA binding domain protein C3496_01600 ENOG4105C8F Beta-lactamase domain protein C3496_01615 ENOG4108V15 phosphotransferase enzyme family C3496_01620 ENOG4108IUM Glycogen debranching enzyme C3496_01635 ENOG4107QSE Dipeptidase C3496_01640 ENOG4105YW5 deoR family transcriptional regulator C3496_01655 ENOG4105CBX hi0933 family C3496_01695 ENOG4108VJ1 Transcriptional regulator (CarD family C3496_01700 ENOG4107EXU Short-chain dehydrogenase reductase Sdr C3496_01720 ENOG4108ZAF Molybdopterin C3496_01725 ENOG4105D7V transposase C3496_01735 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein C3496_01740 ENOG4105CVM Molybdenum cofactor synthesis domain protein C3496_01750 ENOG4105D06 uba thif-type nad fad binding protein C3496_01755 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C3496_01775 ENOG41085GJ domain protein C3496_01785 ENOG4105DWV Homoserine O-trans-acetylase C3496_01795 ENOG4108B31 Spore germination protein C3496_01825 ENOG410605W Major Facilitator C3496_01830 ENOG4107S91 Sodium hydrogen exchanger C3496_01835 ENOG4105NCW Trka-c domain protein C3496_01850 ENOG4105C19 ABC transporter C3496_01870 ENOG4105N5T Radical SAM Protein C3496_01880 ENOG4105CIG ABC transporter C3496_01915 ENOG4105E8V Alpha Beta Hydrolase Fold protein C3496_01920 ENOG4108Z0R Transferase C3496_01925 ENOG4105YVM Phosphoesterase, PA-phosphatase related C3496_01930 ENOG4105BZF Glycosyl transferase (Group 1 C3496_01940 ENOG4108RIR Molybdenum cofactor biosynthesis protein C3496_01955 ENOG4108MK9 spermidine N(1)-acetyltransferase C3496_02005 ENOG4105EGD dinuclear metal center protein, YbgI family C3496_02010 ENOG4105BZU Histidine kinase C3496_02015 ENOG4105BZU Histidine kinase C3496_02020 ENOG4107S9D Alpha beta hydrolase C3496_02045 ENOG4105D2X ABC transporter substrate-binding protein C3496_02055 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component C3496_02105 ENOG4108V2W Carbonate dehydratase C3496_02110 ENOG4105C4M (Ubiquinol oxidase) subunit I C3496_02115 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C3496_02165 ENOG41087YS Phage shock protein A C3496_02210 ENOG4105BZU Histidine kinase C3496_02215 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3496_02240 ENOG4108UGV hypoxanthine phosphoribosyltransferase C3496_02245 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) C3496_02265 ENOG4105C19 ABC transporter C3496_02290 ENOG4107ZTW SNARE associated Golgi C3496_02315 ENOG4105C19 ABC transporter C3496_02320 ENOG41086D8 Transcriptional regulator C3496_02330 ENOG4105CJ1 ABC, transporter C3496_02340 ENOG41082BM Transcriptional regulator, arsr family C3496_02380 ENOG4105C6Z Gluconate C3496_02385 ENOG4105FDP GntR family transcriptional regulator C3496_02405 ENOG41069H0 dihydroorotase EC 3.5.2.3 C3496_02425 ENOG4105DTQ mandelate racemase muconate lactonizing C3496_02440 ENOG4108IPT Naphthoate synthase C3496_02445 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) C3496_02455 ENOG4105E4F Isochorismate synthase C3496_02460 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase C3496_02470 ENOG4105VEQ Cold shock protein C3496_02505 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) C3496_02530 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C3496_02635 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation C3496_02675 ENOG4105KT7 mgtC SapB transporter C3496_02680 ENOG4107PBV potassium channel C3496_02700 ENOG4105WG9 Conserved Protein C3496_02710 ENOG4105CHM Aminotransferase C3496_02715 ENOG4108ZB6 transcriptional regulator AsnC family C3496_02720 ENOG4105C5I Dehydrogenase C3496_02725 ENOG4108MUZ hydrolase C3496_02735 ENOG4105C87 Aminotransferase class I and II C3496_02745 ENOG4105Y38 Kinase-associated protein B C3496_02755 ENOG4107R3E Citrate transporter C3496_02775 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) C3496_02780 ENOG4105KA0 thioesterase Superfamily protein C3496_02800 ENOG4107QPH glycogen) synthase C3496_02820 ENOG4105EJV Membrane C3496_02825 ENOG4105WH5 Teichoic acid glycosylation protein C3496_02835 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C3496_02860 ENOG41069ER domain protein C3496_02875 ENOG4105CEP NADH dehydrogenase C3496_02905 ENOG4105EWC Purine nucleoside phosphorylase C3496_02920 ENOG4108YX9 iron--sulfur cluster insertion protein erpA C3496_02945 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C3496_02950 ENOG4105C4B ABC transporter, permease C3496_02955 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA C3496_02980 ENOG41083MR nifu domain-containing protein C3496_02995 ENOG4108W5N phosphatidylglycerophosphatase a C3496_03010 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C3496_03015 ENOG4105DYS nad(p)h dehydrogenase (quinone) C3496_03025 ENOG4105D4U had-superfamily hydrolase, subfamily iia C3496_03040 ENOG4105CBT Fructose-1,6-bisphosphatase C3496_03060 ENOG4105MMD transcriptional regulator C3496_03065 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) C3496_03070 ENOG4107TXC Transcriptional regulator C3496_03075 ENOG41090T1 Membrane C3496_03100 ENOG4105FAA peptidase M23 C3496_03110 ENOG4105KZD Domain of unknown function (DUF1805) C3496_03115 ENOG4107R8B 5'-nucleotidase C3496_03125 ENOG4105DIW FeS assembly protein SUFB C3496_03130 ENOG4108UNV SUF system FeS assembly protein, NifU family C3496_03135 ENOG4105C9B Cysteine desulfurase C3496_03140 ENOG4105JRK feS assembly protein SufD C3496_03145 ENOG4105C3K feS assembly ATPase SufC C3496_03150 ENOG4105D01 (LipO)protein C3496_03155 ENOG4105D01 (LipO)protein C3496_03160 ENOG4108UMI ABC transporter, permease C3496_03200 ENOG41080E8 Transcriptional regulator, Spx MgsR family C3496_03265 ENOG4108W8B Beta-lactamase domain protein C3496_03270 ENOG4105C1G acyl-Coa dehydrogenase C3496_03280 ENOG4105CHU acetyl-coa acetyltransferase C3496_03300 ENOG4105DZ1 carboxypeptidase C3496_03320 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer C3496_03335 ENOG4108SUT Major Facilitator Superfamily C3496_03340 ENOG4107R7I amino acid C3496_03355 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins C3496_03365 ENOG4107AYK membrAne C3496_03410 ENOG4107ZTW SNARE associated Golgi C3496_03420 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein C3496_03425 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3496_03430 ENOG4105BZU Histidine kinase C3496_03455 ENOG4105C8Q Methyl-accepting chemotaxis C3496_03460 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer C3496_03465 ENOG4105VG1 fes assembly suf system protein C3496_03470 ENOG4105D4Y metalloprotease C3496_03490 ENOG4107T5V SNARE associated Golgi C3496_03495 ENOG4107S91 Sodium hydrogen exchanger C3496_03500 ENOG4105NCW Trka-c domain protein C3496_03515 ENOG4108RMU ferritin dps family protein C3496_03530 ENOG4108URH decarboxylase C3496_03550 ENOG4105D9N nucleoside C3496_03555 ENOG4105D9N nucleoside C3496_03570 ENOG4108RYK Nad-dependent epimerase dehydratase C3496_03590 ENOG4105CV8 reductase C3496_03595 ENOG4105F27 Major Facilitator C3496_03600 ENOG4105KVH Transcriptional regulator C3496_03615 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C3496_03620 ENOG4105D4A Cell wall formation (By similarity) C3496_03630 ENOG4105C8Q Methyl-accepting chemotaxis C3496_03640 ENOG4105WMR Protein CrcB homolog C3496_03660 ENOG4108MK9 spermidine N(1)-acetyltransferase C3496_03665 ENOG4108VY7 phosphate-starvation-inducible protein PsiE C3496_03680 ENOG4108IPW abc transporter atp-binding protein C3496_03685 ENOG4105CM4 permease protein C3496_03720 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) C3496_03730 ENOG4105XZU Preprotein translocase, subunit SecG C3496_03735 ENOG41067MG lrgb family C3496_03755 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) C3496_03785 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3496_03805 ENOG41090VF Stage v sporulation protein ac C3496_03810 ENOG4105CZ3 stage V sporulation protein ad C3496_03825 ENOG4108QY0 Membrane C3496_03830 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C3496_03835 ENOG4105KRI phosphocarrier protein (HPr C3496_03845 ENOG4105CHW UPF0052 protein C3496_03855 ENOG4108Z4K mutator MutT protein C3496_03865 ENOG4105C3M thioredoxin reductase C3496_03875 ENOG4108S4C acetyltransferase C3496_03895 ENOG41086DT Membrane protein of unknown function C3496_03905 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) C3496_03925 ENOG4107TXC Transcriptional regulator C3496_03955 ENOG4105DUM transcriptional regulator, lysR family C3496_03965 ENOG4108WS4 fmn reductase C3496_03980 ENOG4105BZ1 (ABC) transporter C3496_03990 ENOG4105CN1 protease C3496_03995 ENOG4105CRP Part of the ABC transporter FtsEX involved in C3496_04000 ENOG4105CAK Cell division ATP-binding protein ftsE C3496_04020 ENOG4105MS2 ribosomal subunit Interface protein C3496_04025 ENOG4105VEQ Cold shock protein C3496_04030 ENOG41081UC Inherit from COG: Competence protein C3496_04045 ENOG4105KVH Transcriptional regulator C3496_04060 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein C3496_04065 ENOG4108KGH TRANSCRIPTIONal C3496_04070 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase C3496_04075 ENOG4105C6Y Udp-glucose 6-dehydrogenase C3496_04080 ENOG4105ESV Glycosyl transferase, family 4 C3496_04090 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C3496_04110 ENOG4105F8D glycoside hydrolase family 4 C3496_04115 ENOG4105VCP PTS System C3496_04120 ENOG4105CK1 PTS System C3496_04130 ENOG4108JPV Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) C3496_04140 ENOG4105VCP PTS System C3496_04150 ENOG4105VZJ PTS System C3496_04165 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily C3496_04170 ENOG4105ECB domain protein C3496_04175 ENOG4107RSM transcriptional regulator C3496_04210 ENOG4105DAA L-lactate C3496_04220 ENOG4105HYT Uncharacterized metal-binding protein (DUF2227) C3496_04235 ENOG4105E0M Sulfatase C3496_04265 ENOG4107R8N Glycosyl transferase, family 2 C3496_04275 ENOG4105C94 Transporter C3496_04285 ENOG41069ER domain protein C3496_04295 ENOG4105KBK Zinc finger, swim domain protein C3496_04300 ENOG4105C0D helicase C3496_04330 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3496_04340 ENOG4107RBB ABC transporter, permease C3496_04345 ENOG4105C19 ABC transporter C3496_04365 ENOG4105CXY transporter C3496_04380 ENOG4105BZU Histidine kinase C3496_04385 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3496_04390 ENOG4105CMR udp-glucose 4-epimerase C3496_04410 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase C3496_04425 ENOG4105EY8 ABC transporter C3496_04480 ENOG4105MT0 Sporulation transcriptional regulator spoiiid C3496_04495 ENOG4105FRN stage II sporulation protein C3496_04510 ENOG4105DY9 regulatoR C3496_04530 ENOG4106778 Protein of unknown function (DUF1146) C3496_04535 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) C3496_04540 ENOG4105C8S subunit m C3496_04545 ENOG4105D65 subunit l C3496_04575 ENOG4105CYU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain C3496_04585 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain C3496_04590 ENOG4105BZU Histidine kinase C3496_04640 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) C3496_04645 ENOG41062M3 atp synthase C3496_04675 ENOG4108YZG isomerase C3496_04695 ENOG4108VGI doxx family C3496_04700 ENOG4107XC4 flavin reductase domain protein, FMN-binding C3496_04720 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C3496_04730 ENOG4108ZXQ stage ii sporulation protein r C3496_04735 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) C3496_04740 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) C3496_04760 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) C3496_04765 ENOG4105CBT Fructose-1,6-bisphosphatase C3496_04775 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C3496_04810 ENOG4105C1G acyl-Coa dehydrogenase C3496_04815 ENOG4105C1G acyl-Coa dehydrogenase C3496_04820 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C3496_04830 ENOG4105DF6 Fe-S oxidoreductase C3496_04845 ENOG4105BZU Histidine kinase C3496_04870 ENOG4105BZU Histidine kinase C3496_04875 ENOG4105KCT ABC transporter C3496_04880 ENOG4108M15 ABC transporter C3496_04885 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) C3496_04895 ENOG4105IIU Aminopeptidase C3496_04915 ENOG4105EMN RNA polymerase sigma factor C3496_04925 ENOG410684U Domain of unknown function (DUF1934) C3496_04950 ENOG4105CYW agmatinase C3496_04960 ENOG4105DXB Major Facilitator superfamily C3496_04965 ENOG4107SWG transcriptional regulator MERR family C3496_04970 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C3496_04975 ENOG4105BZ4 penicillin-binding protein C3496_04980 ENOG4108XFG YwhD family C3496_04985 ENOG4108Z4T Peptidase M50 C3496_04990 ENOG41069HH 4-oxalocrotonate tautomerase C3496_04995 ENOG4105DCI Phosphohydrolase C3496_05000 ENOG4108MES Periplasmic binding protein C3496_05005 ENOG4105E0A ABC, transporter C3496_05010 ENOG4105EHG Permease protein C3496_05015 ENOG4105DQ5 transport system permease protein C3496_05025 ENOG4108VCI transcription factor, rsfa family C3496_05040 ENOG4108IJ2 phosphate acetyltransferase C3496_05055 ENOG4108VKI Cell wall hydrolase C3496_05075 ENOG4107SVH Potassium channel protein C3496_05085 ENOG410667J hydrolase C3496_05090 ENOG4105VCH membrane C3496_05100 ENOG4108TU7 Inherit from COG: (ABC) transporter C3496_05105 ENOG4105CJ1 ABC, transporter C3496_05110 ENOG41090WU lipolytic protein G-D-S-L family C3496_05125 ENOG4105D6E homoserine dehydrogenase C3496_05150 ENOG4108Y4K DNA-binding transcriptional activator C3496_05160 ENOG4105WH1 Two component transcriptional regulator luxr family C3496_05165 ENOG4105BZU Histidine kinase C3496_05170 ENOG4105DWF phosphomethylpyrimidine kinase C3496_05175 ENOG4105BZU Histidine kinase C3496_05180 ENOG4105VCD cytoplasmic protein C3496_05185 ENOG4105D22 carbon starvation protein C3496_05190 ENOG4105DY9 regulatoR C3496_05195 ENOG41079KZ Major Facilitator Superfamily C3496_05215 ENOG4105EN6 Membrane C3496_05220 ENOG4106YBV Methyl-accepting chemotaxis C3496_05230 ENOG4108S4H thioesterase Superfamily protein C3496_05240 ENOG4105JEU Glycosyl transferase, family 2 C3496_05245 ENOG4105C5H ABC transporter C3496_05255 ENOG41067SE Tetr family transcriptional regulator C3496_05265 ENOG4105E0X reductase C3496_05270 ENOG4106F5Q Membrane C3496_05285 ENOG4105DY9 regulatoR C3496_05290 ENOG4108HRK Histidine kinase C3496_05295 ENOG4107RGD Major Facilitator superfamily C3496_05315 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C3496_05325 ENOG4105IW1 AmiS UreI transporter C3496_05335 ENOG4105CMR udp-glucose 4-epimerase C3496_05340 ENOG4108UT2 hemolysin iii C3496_05350 ENOG4105C1J atp-dependent rna helicase C3496_05360 ENOG4105DPN Oligoendopeptidase f C3496_05380 ENOG4105C0H protease C3496_05385 ENOG4105Q2H domain protein C3496_05400 ENOG4105BZU Histidine kinase C3496_05405 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3496_05435 ENOG4105CDU Replicative dna helicase C3496_05445 ENOG4105BZR domain protein C3496_05450 ENOG4108XMW Membrane C3496_05460 ENOG4108UUM single-stranded DNA-binding protein C3496_05470 ENOG4105C3G gtp-binding protein C3496_05475 ENOG4105VDK protein, conserved in bacteria C3496_05480 ENOG4105D8X mechanosensitive ion channel C3496_05485 ENOG4108ZDA Sporulation protein YyaC C3496_05490 ENOG4105FA0 parb-like partition protein C3496_05495 ENOG4107QJE Chromosome Partitioning Protein C3496_05525 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins C3496_05545 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) C3496_05550 ENOG410848D S4 domain protein YaaA C3496_05565 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C3496_05600 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C3496_05635 ENOG4105ZMH deoxynucleoside kinase C3496_05645 ENOG4105GTG Isochorismatase C3496_05655 ENOG4108Z6B deaminase C3496_05665 ENOG4105C6E dna polymerase iii C3496_05685 ENOG41067KS pro-sigma K processing C3496_05720 ENOG4105CXN decarboxylase C3496_05730 ENOG4105FA2 dna polymerase iii C3496_05735 ENOG4105MA4 psp1 domain protein C3496_05745 ENOG41060K3 Methyltransferase C3496_05760 ENOG4105KRN Transcriptional regulator, abrb family C3496_05770 ENOG4105F8V Hydrolase, tatD family C3496_05775 ENOG4105HVR Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity) C3496_05785 ENOG4105XFA sporulation peptidase YabG C3496_05790 ENOG4105W42 Veg protein C3496_05805 ENOG4105DFT pur operon repressor C3496_05815 ENOG4105KME endoribonuclease L-psp C3496_05830 ENOG4105C5T Phosphoribosyl pyrophosphate synthase C3496_05845 ENOG4108JA2 transcriptioN-repair coupling factor C3496_05850 ENOG4108M14 stage v sporulation protein t C3496_05860 ENOG4108IY2 MazG family C3496_05865 ENOG41082I2 s4 domain protein C3496_05870 ENOG4105VYY sporulation protein yabp C3496_05885 ENOG41060GV RNA binding s1 domain protein C3496_05910 ENOG4108UGV hypoxanthine phosphoribosyltransferase C3496_05915 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C3496_05930 ENOG4105C6T cysteine synthase C3496_05935 ENOG4105CRQ synthase (Component I) C3496_05940 ENOG4105DDQ anthranilate synthase C3496_05945 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 C3496_05950 ENOG4105EEI dihydropteroate synthase C3496_05955 ENOG4105KRF dihydroneopterin aldolase C3496_05960 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase C3496_05970 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) C3496_06060 ENOG4108Z0C Uvrb UvrC protein C3496_06075 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) C3496_06085 ENOG4105CTP PilT protein domain protein C3496_06105 ENOG4105D7W serine acetyltransferase C3496_06120 ENOG4105C2N RNA methyltransferase TrmH family group 3 C3496_06125 ENOG4105M0M Tetracycline resistance protein C3496_06130 ENOG4105QIV RNA polymerase C3496_06145 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) C3496_06170 ENOG4107Y49 methyltransferase C3496_06185 ENOG4105XPM ribosomal protein C3496_06290 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) C3496_06315 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) C3496_06325 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) C3496_06335 ENOG41067V7 50S ribosomal protein L36 C3496_06365 ENOG4108JJB ABC transporter C3496_06370 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) C3496_06375 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) C3496_06400 ENOG4105D1F ATP-binding protein C3496_06415 ENOG4108NMV polysaccharide deacetylase C3496_06495 ENOG4105C8B TIGR00159 family C3496_06500 ENOG4107U5W ybbr family C3496_06600 ENOG4108VQT Alpha beta hydrolase fold protein C3496_06610 ENOG4105CMG Carbohydrate kinase C3496_06620 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) C3496_06625 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein C3496_06655 ENOG4108PSK reductase C3496_06660 ENOG4108UMI ABC transporter, permease C3496_06670 ENOG4105D01 (LipO)protein C3496_06675 ENOG4105EE1 crotonyl-CoA reductase C3496_06685 ENOG4105IQ5 FAD linked oxidase domain protein C3496_06700 ENOG4105C2C drug resistance transporter, Bcr CflA C3496_06715 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C3496_06720 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C3496_06725 ENOG4105C3U ABC transporter C3496_06730 ENOG4108JQ7 (ABC) transporter C3496_06755 ENOG4105U5Y Transcriptional regulator C3496_06765 ENOG4108J59 Extracellular solute-binding protein, family 5 C3496_06770 ENOG4108J59 Extracellular solute-binding protein, family 5 C3496_06780 ENOG4105II7 pyrroline-5-carboxylate reductase C3496_06785 ENOG4107XDY Nicotinamide Mononucleotide Transporter C3496_06795 ENOG4105E0C molybdate abc transporter C3496_06800 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein C3496_06805 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family C3496_06840 ENOG4105F6E Acyl-transferase C3496_06865 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) C3496_06890 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) C3496_06915 ENOG4105C5H ABC transporter C3496_06920 ENOG4105BZU Histidine kinase C3496_06925 ENOG4105WH1 Two component transcriptional regulator luxr family C3496_06930 ENOG4105CJ1 ABC, transporter C3496_06935 ENOG41090VJ ABC-2 type transporter C3496_06940 ENOG4108KYE ABC-2 type transporter C3496_06955 ENOG4105DEF Extracellular solute-binding protein, family 5 C3496_06965 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C3496_06970 ENOG4105C3U ABC transporter C3496_06975 ENOG4108JQ7 (ABC) transporter C3496_06980 ENOG410667J hydrolase C3496_07015 ENOG4105E6K 4-Hydroxyphenylpyruvate dioxygenase C3496_07020 ENOG4105ERH Fumarylacetoacetate hydrolase C3496_07035 ENOG4105CUB amino acid C3496_07045 ENOG4105CPF Cell wall formation (By similarity) C3496_07050 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) C3496_07075 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein C3496_07080 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C3496_07090 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) C3496_07190 ENOG4105K8N protein family UPF0079, ATPase C3496_07195 ENOG41072GX Peptidase M22 Glycoprotease C3496_07200 ENOG410801F ribosomal-protein-alanine acetyltransferase C3496_07205 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C3496_07210 ENOG4105C5H ABC transporter C3496_07225 ENOG4108TYN CAAX amino terminal protease family protein C3496_07245 ENOG4105C7N Xanthine uracil vitamin C permease C3496_07255 ENOG4105BZU Histidine kinase C3496_07280 ENOG4107ZXU DSBA oxidoreductase C3496_07360 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C3496_07380 ENOG4105SX7 Transporter C3496_07410 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) C3496_07415 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit C3496_07420 ENOG4105C83 adenylosuccinate lyase C3496_07430 ENOG4105VR9 phosphoribosylformylglycinamidine synthase C3496_07455 ENOG4108V3E phosphoribosylglycinamide formyltransferase C3496_07465 ENOG4105C12 Phosphoribosylglycinamide synthetase C3496_07495 ENOG4105C4R Atp-dependent dna helicase C3496_07525 ENOG4108W2Y isochorismatase C3496_07540 ENOG4108UMI ABC transporter, permease C3496_07545 ENOG4105D01 (LipO)protein C3496_07565 ENOG410834F Transcriptional regulator C3496_07570 ENOG4107I77 yiaA/B two helix domain C3496_07590 ENOG4105CBD Diacylglycerol kinase C3496_07595 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) C3496_07600 ENOG4108JPW Aminotransferase C3496_07610 ENOG4105C26 Dehydrogenase C3496_07615 ENOG4105KPY Small multidrug resistance protein C3496_07635 ENOG4105D9N nucleoside C3496_07640 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C3496_07655 ENOG4105BZU Histidine kinase C3496_07660 ENOG4108W15 Protein of unknown function (DUF1456) C3496_07675 ENOG4105DTQ mandelate racemase muconate lactonizing C3496_07685 ENOG4105DFD Na H antiporter C3496_07705 ENOG4105D3R alkyl hydroperoxide reductase C3496_07710 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) C3496_07720 ENOG4107W7X Aldolase C3496_07725 ENOG4105EHG Permease protein C3496_07730 ENOG4105DQ5 transport system permease protein C3496_07735 ENOG4108V5C ABC transporter C3496_07765 ENOG4106UIA C3496_07770 ENOG4106UIA C3496_07795 ENOG4105BZU Histidine kinase C3496_07815 ENOG410756H nucleotidyltransferase C3496_07820 ENOG4105D2S major facilitator superfamily C3496_07835 ENOG4105E5Q amino acid AbC transporter C3496_07840 ENOG4105EAB amino acid AbC transporter C3496_07850 ENOG4105C8Q Methyl-accepting chemotaxis C3496_07860 ENOG4105CI1 PTS System C3496_07895 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter C3496_07910 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component C3496_07925 ENOG4105C5H ABC transporter C3496_07950 ENOG41062JF Transcriptional regulator C3496_07970 ENOG4105DEU major facilitator superfamily C3496_08005 ENOG4108N0M stress protein C3496_08010 ENOG4106FN3 tellurium resistance protein C3496_08015 ENOG4106FN3 tellurium resistance protein C3496_08020 ENOG4107TS3 membrane protein, TerC C3496_08025 ENOG4108TTB tellurium resistance protein C3496_08040 ENOG41068PA UPF0435 protein C3496_08045 ENOG4105KJF protein tyrosine phosphatase C3496_08055 ENOG4107U9T Pfam:Ribonuclease_BN C3496_08065 ENOG4105C59 p-type ATPase C3496_08070 ENOG4108IPJ Membrane C3496_08080 ENOG4105C3F Signal peptidase i C3496_08090 ENOG4107ZTW SNARE associated Golgi C3496_08105 ENOG410606W general stress protein C3496_08110 ENOG4105UPD Calcium Proton C3496_08150 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) C3496_08160 ENOG4108JUB Transcriptional regulator C3496_08170 ENOG4108IQI permease C3496_08205 ENOG4105CSV Glutaminase C3496_08220 ENOG4108A04 Beta-lactamase C3496_08240 ENOG4105CKK Glycosyl transferase, family 2 C3496_08245 ENOG4107QQG Dehydrogenase C3496_08265 ENOG4105F1A Pyruvate formate-lyase C3496_08285 ENOG4105CI2 imidazolone-5-propionate hydrolase C3496_08290 ENOG4105ECP epimerase C3496_08320 ENOG41067AE Membrane-bound metal-dependent hydrolase C3496_08325 ENOG4105CEN a g-specific adenine glycosylase C3496_08330 ENOG4106BXE C3496_08350 ENOG4105BZ1 (ABC) transporter C3496_08355 ENOG4107NBY Membrane C3496_08360 ENOG4105CBC glutamate synthase C3496_08370 ENOG4108IUW ABC transporter C3496_08390 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C3496_08395 ENOG4105G5W regulator Fur family C3496_08515 ENOG4108JQC penicillin-binding protein 1A C3496_08520 ENOG4107ZQN disulfide bond C3496_08530 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) C3496_08540 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) C3496_08545 ENOG4105BZU Histidine kinase C3496_08555 ENOG4105CYN Serine protein kinase C3496_08585 ENOG4105C94 Transporter C3496_08600 ENOG4105DZ6 Band 7 protein C3496_08610 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism C3496_08615 ENOG4108V9W transcriptional regulatory protein C3496_08620 ENOG4105D4T Citrate transporter C3496_08650 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator C3496_08655 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C3496_08660 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component C3496_08665 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component C3496_08670 ENOG4105BZ7 extracellular solute-binding protein family 1 C3496_08675 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) C3496_08680 ENOG4108STX response regulator C3496_08685 ENOG4105US7 Histidine kinase C3496_08710 ENOG4108MRH transcriptional regulatory protein C3496_08720 ENOG4105C6K Malic enzyme C3496_08730 ENOG4108UZ3 Transporter C3496_08735 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C3496_08745 ENOG4105BZU Histidine kinase C3496_08750 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3496_08760 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) C3496_08765 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) C3496_08770 ENOG4108JB9 formate dehydrogenase C3496_08790 ENOG4105CUB amino acid C3496_08805 ENOG4105C59 p-type ATPase C3496_08810 ENOG4105DAP Nicotinate phosphoribosyltransferase C3496_08840 ENOG41073R8 VanW family C3496_08845 ENOG4108KGH TRANSCRIPTIONal C3496_08850 ENOG4105D9N nucleoside C3496_08855 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase C3496_08860 ENOG4105C37 (CBS) domain C3496_08865 ENOG4108IJ0 Aspartate ammonia-lyase C3496_08870 ENOG4105DAA L-lactate C3496_08885 ENOG4105DUX Transporter C3496_08890 ENOG4108MES Periplasmic binding protein C3496_08895 ENOG4105DQ5 transport system permease protein C3496_08900 ENOG4108IHU transport system permease protein C3496_08905 ENOG4105E0A ABC, transporter C3496_08910 ENOG4105DMQ Methyltransferase C3496_08920 ENOG4105EXW epimerase dehydratase C3496_08925 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) C3496_08935 ENOG4107T89 von Willebrand factor, type A C3496_08940 ENOG4105GMT ATPase associated with various cellular activities aaa_5 C3496_08945 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C3496_08960 ENOG4105BZU Histidine kinase C3496_08965 ENOG4105D5Q Arginine ornithine antiporter C3496_08970 ENOG4107414 GntR family transcriptional regulator C3496_08975 ENOG4105C5Y PTS System C3496_08980 ENOG4105CG3 alpha amylase, catalytic region C3496_08995 ENOG4105E1K spore germination protein C3496_09005 ENOG4105CRN Aminoglycoside phosphotransferase C3496_09010 ENOG4105BZG amino acid carrier protein C3496_09020 ENOG4105CDA abc transporter atp-binding protein C3496_09025 ENOG4105CT1 (ABC) transporter C3496_09030 ENOG4105EAD ABC transporter C3496_09035 ENOG4105DRP amino acid AbC transporter C3496_09040 ENOG4108IQI permease C3496_09065 ENOG4105D29 Helix-turn-helix type 11 domain protein C3496_09070 ENOG4105NAE bifunctional deaminase-reductase domain protein C3496_09075 ENOG4105BZU Histidine kinase C3496_09090 ENOG4105CHH sulfate transporter C3496_09095 ENOG41068KF Universal stress protein C3496_09105 ENOG4105DEF Extracellular solute-binding protein, family 5 C3496_09115 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C3496_09120 ENOG4108JQ7 (ABC) transporter C3496_09130 ENOG4105CXY transporter C3496_09135 ENOG41067TZ transcriptional regulator, MarR family C3496_09140 ENOG4105C0R drug resistance transporter emrb qaca subfamily C3496_09145 ENOG4105ETE Transcriptional regulator (LacI family C3496_09150 ENOG4108RVA ribokinase C3496_09160 ENOG4105C2J ABC transporter C3496_09165 ENOG4105CNN ABC, transporter C3496_09170 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator C3496_09175 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) C3496_09185 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C3496_09240 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer C3496_09245 ENOG41069ER domain protein C3496_09250 ENOG4105VZ8 Transcriptional regulator C3496_09255 ENOG4107D63 C3496_09265 ENOG4105DUX Transporter C3496_09285 ENOG4105C85 amino acid C3496_09290 ENOG4105C7N Xanthine uracil vitamin C permease C3496_09305 ENOG4105MA6 gCN5-related N-acetyltransferase C3496_09330 ENOG4105BZ9 Cytochrome C oxidase, subunit I C3496_09335 ENOG4105E2S oxidase) subunit II C3496_09340 ENOG4108IQI permease C3496_09355 ENOG4106CAD Protein of unknown function (DUF3311) C3496_09360 ENOG4105E1V na solute symporter C3496_09375 ENOG4108NHD germination protein C3496_09385 ENOG4105CE1 Ferrous iron transport protein b C3496_09390 ENOG4105CE1 Ferrous iron transport protein b C3496_09395 ENOG4105CE1 Ferrous iron transport protein b C3496_09400 ENOG4105CVA phosphate C3496_09405 ENOG4105C8U phosphate abc transporter C3496_09410 ENOG4105E2Z phosphate ABC transporter (Permease C3496_09540 ENOG41080XQ Signal transduction protein with cbs domains C3496_09565 ENOG4105ETU transcriptional activator (TenA C3496_09575 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component C3496_09585 ENOG4108VEU Thiamine monophosphate synthase C3496_09590 ENOG41080HI glycine oxidase C3496_09605 ENOG4105D06 uba thif-type nad fad binding protein C3496_09610 ENOG4105DWF phosphomethylpyrimidine kinase C3496_09665 ENOG4108INS Transcriptional regulator C3496_09680 ENOG4105C7N Xanthine uracil vitamin C permease C3496_09690 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein C3496_09725 ENOG4108B31 Spore germination protein C3496_09745 ENOG4107Y03 Nitroreductase C3496_09750 ENOG4105ED1 spovr family C3496_09760 ENOG4105J4Q Transcriptional regulator C3496_09780 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase C3496_09785 ENOG4105XTG Pfam:DUF156 C3496_09790 ENOG4105VFE sira family C3496_09795 ENOG4107TPS domain protein C3496_09800 ENOG4105VFE sira family C3496_09805 ENOG4105VFE sira family C3496_09815 ENOG4105VFE sira family C3496_09825 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase C3496_09830 ENOG41087NI Sulfite exporter TauE/SafE C3496_09840 ENOG4108KGH TRANSCRIPTIONal C3496_09865 ENOG4105EMD TRANSCRIPTIONal C3496_09870 ENOG4105VCP PTS System C3496_09875 ENOG4105VZJ PTS System C3496_09895 ENOG41069ER domain protein C3496_09900 ENOG4107RBB ABC transporter, permease C3496_09905 ENOG4105C19 ABC transporter C3496_09940 ENOG4105WEF catalase C3496_09975 ENOG4107T5V SNARE associated Golgi C3496_10010 ENOG4105CUB amino acid C3496_10015 ENOG4107RWR Sodium hydrogen exchanger C3496_10025 ENOG4106KNT transcriptional regulator C3496_10065 ENOG4108YXU transcriptional regulator AsnC family C3496_10075 ENOG4105KPY Small multidrug resistance protein C3496_10105 ENOG4105NF4 modulator of drug activity C3496_10110 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) C3496_10115 ENOG4105E5W Transporter C3496_10125 ENOG4107RKG DJ-1/PfpI family C3496_10130 ENOG4105CH6 catalase C3496_10140 ENOG4105D5Q Arginine ornithine antiporter C3496_10145 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) C3496_10155 ENOG4105C26 Dehydrogenase C3496_10175 ENOG4105BZ1 (ABC) transporter C3496_10180 ENOG4105BZ1 (ABC) transporter C3496_10195 ENOG4105DRP amino acid AbC transporter C3496_10200 ENOG4105CDA abc transporter atp-binding protein C3496_10215 ENOG410839P C3496_10250 ENOG4107FQX Alpha-acetolactate decarboxylase C3496_10285 ENOG4105D4P Coproporphyrinogen iii oxidase C3496_10305 ENOG4105CHH sulfate transporter C3496_10315 ENOG4105CGU Enoyl-CoA hydratase C3496_10330 ENOG4105DER m42 family C3496_10350 ENOG4105CTU Proline racemase C3496_10380 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C3496_10390 ENOG4108JQ7 (ABC) transporter C3496_10400 ENOG4105CSH Transporter C3496_10410 ENOG4108MRH transcriptional regulatory protein C3496_10500 ENOG4105CVR type I restriction-modification system C3496_10510 ENOG4105DZR Type I site-specific deoxyribonuclease C3496_10540 ENOG4105CDU Replicative dna helicase C3496_10565 ENOG4105C0R drug resistance transporter emrb qaca subfamily C3496_10620 ENOG4107P5I polyketide synthase C3496_10625 ENOG4108IG5 Transcriptional regulator C3496_10635 ENOG4105CID antiterminator C3496_10640 ENOG4105C5Y PTS System C3496_10645 ENOG4105CS2 ec 3.2.1.21 C3496_10655 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase C3496_10700 ENOG4105CMT Dihydroxyacetone kinase C3496_10715 ENOG4105CMT Dihydroxyacetone kinase C3496_10765 ENOG4105DW3 Response regulator receiver modulated metal dependent phosphohydrolase C3496_10845 ENOG4105WN5 stage II sporulation protein C3496_10855 ENOG4108N6D Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3496_10865 ENOG4108MJI response regulator C3496_10870 ENOG4105BZU Histidine kinase C3496_10875 ENOG4105BZU Histidine kinase C3496_10900 ENOG4105K8R UPF0145 protein C3496_10910 ENOG4105D7V transposase C3496_10925 ENOG4105ENE Histidine kinase C3496_10930 ENOG4108VB1 regulatoR C3496_10960 ENOG4107VRP DNA repair exonuclease C3496_10965 ENOG4106D4I domain protein C3496_11020 ENOG4108MUZ hydrolase C3496_11050 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator C3496_11065 ENOG4105C6V Glycerol-3-phosphate dehydrogenase C3496_11075 ENOG4105EMN RNA polymerase sigma factor C3496_11085 ENOG4105CNI cell division protein FtsW C3496_11100 ENOG4105C57 major facilitator superfamily C3496_11105 ENOG4105C0R drug resistance transporter emrb qaca subfamily C3496_11115 ENOG4105EEM helicase C3496_11120 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C3496_11150 ENOG4105K59 histidine triad (HIT) protein C3496_11255 ENOG410905X membrane-flanked domain protein C3496_11260 ENOG4105CKV Membrane C3496_11280 ENOG410905X membrane-flanked domain protein C3496_11285 ENOG4105CKV Membrane C3496_11290 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation C3496_11295 ENOG4105BZ4 penicillin-binding protein C3496_11310 ENOG4105C1Q protoporphyrinogen oxidase C3496_11335 ENOG4105NA0 Transcriptional regulator C3496_11350 ENOG4105ECB domain protein C3496_11365 ENOG4108MK9 spermidine N(1)-acetyltransferase C3496_11375 ENOG4105D29 Helix-turn-helix type 11 domain protein C3496_11390 ENOG4106AXD C3496_11395 ENOG4108RQ5 Beta-lactamase domain-containing protein C3496_11400 ENOG4105DF9 Lipoate-protein, ligase C3496_11410 ENOG4105CEY Amp-dependent synthetase and ligase C3496_11425 ENOG4106XHW Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity) C3496_11430 ENOG4107RN3 metallophosphoesterase C3496_11440 ENOG4107TVP HD domain protein C3496_11445 ENOG4107YPT transcriptional regulator C3496_11450 ENOG4105C57 major facilitator superfamily C3496_11460 ENOG4108AEY RNA polymerase sigma factor C3496_11470 ENOG41086D8 Transcriptional regulator C3496_11490 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C3496_11515 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 C3496_11520 ENOG4105C8Q Methyl-accepting chemotaxis C3496_11535 ENOG4107QP3 malate synthase g C3496_11555 ENOG4105VEQ Cold shock protein C3496_11570 ENOG4105XVF Competence transcription factor C3496_11590 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation C3496_11635 ENOG4105ERH Fumarylacetoacetate hydrolase C3496_11660 ENOG4105CAQ asparagine synthetase C3496_11670 ENOG4105CH6 catalase C3496_11675 ENOG4105BZU Histidine kinase C3496_11700 ENOG4105QNR S1 RNA binding domain protein C3496_11705 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C3496_11715 ENOG4107AYK membrAne C3496_11720 ENOG41073B9 C3496_11730 ENOG4108KP7 hydrolase C3496_11745 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit C3496_11775 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C3496_11780 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C3496_11800 ENOG4105C31 Tryptophanyl-tRNA synthetase C3496_11820 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C3496_11825 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C3496_11835 ENOG4108JQ7 (ABC) transporter C3496_11840 ENOG4105UQX Mate efflux family protein C3496_11865 ENOG4108ZCF integral membrane protein C3496_11875 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C3496_11885 ENOG4105DPN Oligoendopeptidase f C3496_11900 ENOG4108Z18 K06886 hemoglobin C3496_11905 ENOG4105MIX Adenylate cyclase C3496_11920 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C3496_11925 ENOG4105EMS pseudouridine synthase C3496_11945 ENOG4105K64 Glycosyl transferase, family 2 C3496_11965 ENOG4107TVC Glycosyl transferase, family 2 C3496_11985 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) C3496_11990 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase C3496_12000 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase C3496_12075 ENOG4105CK7 Sodium proline symporter C3496_12085 ENOG4105CRQ synthase (Component I) C3496_12090 ENOG4105DDQ anthranilate synthase C3496_12195 ENOG4105C7S Dehydrogenase C3496_12205 ENOG4105VZ8 Transcriptional regulator C3496_12305 ENOG4108NE4 C3496_12335 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C3496_12345 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) C3496_12360 ENOG4105DZ1 carboxypeptidase C3496_12365 ENOG4105VFR signal peptidase C3496_12400 ENOG4105C26 Dehydrogenase C3496_12410 ENOG4105F38 ABC transporter, permease C3496_12415 ENOG4105D38 putrescine abc transporter C3496_12420 ENOG4107RUE extracellular solute-binding protein family 1 C3496_12430 ENOG4105EYF MMPL domain protein C3496_12440 ENOG4108YBP pseudouridine synthase C3496_12450 ENOG4105K4I Scp-like extracellular C3496_12455 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C3496_12460 ENOG4105CQB FAD linked oxidase domain protein C3496_12475 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3496_12480 ENOG4105BZU Histidine kinase C3496_12485 ENOG4105JXH GntR family transcriptional regulator C3496_12505 ENOG4106A3R peptidase C3496_12515 ENOG4108QTI )-transporter C3496_12520 ENOG4107TS3 membrane protein, TerC C3496_12525 ENOG4105CZN Potassium uptake protein C3496_12530 ENOG410681C small acid-soluble spore protein C3496_12535 ENOG4108Z7G MaoC domain protein dehydratase C3496_12555 ENOG4105CHR reductase C3496_12590 ENOG4105C4Y ABC transporter C3496_12595 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C3496_12600 ENOG4107RCV ABC transporter, permease C3496_12620 ENOG4105E98 transcriptional regulator DeoR family C3496_12635 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) C3496_12645 ENOG4105PXI polysaccharide deacetylase C3496_12655 ENOG4105BZU Histidine kinase C3496_12660 ENOG41090MY MarR family Transcriptional regulator C3496_12670 ENOG4106DF1 C3496_12680 ENOG4105BZU Histidine kinase C3496_12690 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase C3496_12695 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) C3496_12740 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) C3496_12755 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C3496_12760 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family C3496_12765 ENOG4105CZV ABC transporter C3496_12775 ENOG4105CJ1 ABC, transporter C3496_12815 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A C3496_12820 ENOG4105EA8 2-Nitropropane dioxygenase C3496_12825 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD C3496_12835 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein C3496_12860 ENOG4105NQC Flavodoxin C3496_12905 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) C3496_12935 ENOG4105CZN Potassium uptake protein C3496_12940 ENOG41063Y9 C3496_12945 ENOG4105KBJ sporulation protein ytfj C3496_12975 ENOG4105CM2 brancheD-chain amino acid aminotransferase C3496_12980 ENOG4105C7K acetolactate synthase C3496_12985 ENOG4108ZP8 Acetolactate synthase small subunit C3496_13060 ENOG4107RVV histidinol phosphate phosphatase, hisj family C3496_13075 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase C3496_13080 ENOG4105E0M Sulfatase C3496_13090 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) C3496_13110 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) C3496_13115 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) C3496_13125 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C3496_13130 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein C3496_13135 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein C3496_13145 ENOG4105C8J )-transporter C3496_13165 ENOG4105DFD Na H antiporter C3496_13185 ENOG4105ENE Histidine kinase C3496_13190 ENOG4105WH1 Two component transcriptional regulator luxr family C3496_13210 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) C3496_13260 ENOG4105CJ3 phosphate transporter C3496_13265 ENOG4107GRR phosphate transport regulator C3496_13270 ENOG4105BZ4 penicillin-binding protein C3496_13285 ENOG4105BZU Histidine kinase C3496_13290 ENOG4105I3N Conserved Protein C3496_13305 ENOG4105BZU Histidine kinase C3496_13335 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C3496_13340 ENOG4105DZ1 carboxypeptidase C3496_13345 ENOG4108JIC nucleoside recognition domain protein C3496_13355 ENOG4105FE9 pseudouridine synthase C3496_13365 ENOG4107TWT Cytochrome c biogenesis protein C3496_13370 ENOG4105CRE cytochrome C C3496_13375 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3496_13380 ENOG4105BZU Histidine kinase C3496_13385 ENOG4108WBT adenosyltransferase C3496_13390 ENOG41063SB peptidase C3496_13400 ENOG4108SAX Membrane C3496_13415 ENOG4105C9U ATP-dependent DNA helicase RecQ C3496_13420 ENOG4105I7S Abortive infection protein C3496_13430 ENOG4107RGJ metallophosphoesterase C3496_13435 ENOG4107X2D transcriptional regulator, merr family C3496_13440 ENOG4108S6Z Negative regulator of genetic competence C3496_13465 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase C3496_13470 ENOG4105HDK L-asparaginase C3496_13505 ENOG4105S2F C3496_13510 ENOG41065D1 C3496_13540 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) C3496_13555 ENOG4105XXQ heptaprenyl diphosphate synthase component I C3496_13565 ENOG4105EAH synthase C3496_13590 ENOG41068YB TPR repeat-containing protein C3496_13605 ENOG4105DQV Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity) C3496_13610 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) C3496_13615 ENOG4105PE6 Menaquinol-cytochrome c reductase, cytochrome b c subunit C3496_13650 ENOG4108JYZ YitT family C3496_13660 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase C3496_13675 ENOG4105FJR Lmbe family C3496_13680 ENOG4105CPK Glycosyl transferase (Group 1 C3496_13720 ENOG4105DVT helicase C3496_13725 ENOG4105YAC C3496_13745 ENOG4105CSM endonuclease III C3496_13755 ENOG4105BZ4 penicillin-binding protein C3496_13815 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) C3496_13825 ENOG4105DVT helicase C3496_13830 ENOG4105CTD carboxy-peptidase C3496_13845 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) C3496_13855 ENOG4105C2W permease C3496_13860 ENOG4105DHF Membrane C3496_13870 ENOG410890F Dynamin family C3496_13880 ENOG4108W0I acetyltransferase C3496_13890 ENOG4105KHC sulfurtransferase C3496_13915 ENOG4106032 Glutathionylspermidine synthase C3496_13975 ENOG4105CPK Glycosyl transferase (Group 1 C3496_14010 ENOG41081VK Ribonuclease C3496_14075 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C3496_14085 ENOG4107RWR Sodium hydrogen exchanger C3496_14090 ENOG4105CN5 Metallo-Beta-Lactamase C3496_14095 ENOG4108Z5V transcriptional regulator, merr family C3496_14105 ENOG4105H67 Protein of unknown function (DUF421) C3496_14110 ENOG41080C8 DUF218 domain C3496_14165 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) C3496_14175 ENOG4107R0U MotA TolQ exbB proton channel C3496_14180 ENOG4105ER2 Ompa motb domain protein C3496_14185 ENOG4107YTP response regulator receiver protein C3496_14190 ENOG4105CBS Chea signal transduction histidine kinase C3496_14195 ENOG4105DD5 Flagellar motor switch protein C3496_14210 ENOG4105BZU Histidine kinase C3496_14230 ENOG4105E1Q flagellar hook-associated protein C3496_14235 ENOG4105DTJ flagellar hook-associated protein C3496_14255 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) C3496_14260 ENOG4108ZC9 flagellar basal-body rod protein flgc C3496_14265 ENOG41075Z6 flagellar hook-basal body complex protein fliE C3496_14270 ENOG4107U2N Flagellar M-ring protein C3496_14275 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C3496_14305 ENOG4105BZE flagellar hook protein, FlgE C3496_14320 ENOG4107R88 Chemotaxis protein (CheV) C3496_14330 ENOG4105I03 Flagellin C3496_14335 ENOG4105I03 Flagellin C3496_14340 ENOG4105E4C Lytic transglycosylase catalytic C3496_14350 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C3496_14355 ENOG4105DD5 Flagellar motor switch protein C3496_14365 ENOG4105CN7 Flagellar biosynthetic protein FliP C3496_14370 ENOG4105VS8 Flagellar biosynthetic protein fliq C3496_14380 ENOG4105D00 flagellar biosynthetic protein flhB C3496_14385 ENOG4105D7B Flagellar biosynthesis protein flha C3496_14390 ENOG4105FZW flagellar biosynthesis regulator FlhF C3496_14395 ENOG4105KTQ flagellar basal-body rod protein C3496_14400 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C3496_14425 ENOG4108RZE Tetr family transcriptional regulator C3496_14445 ENOG4105KAC Antibiotic biosynthesis monooxygenase C3496_14470 ENOG4105DUM transcriptional regulator, lysR family C3496_14475 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) C3496_14480 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein C3496_14485 ENOG4108N53 binding-protein-dependent transport systems inner membrane Component C3496_14490 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) C3496_14530 ENOG4105CVJ phosphoglycerate mutase C3496_14545 ENOG4105K56 Transcriptional regulator C3496_14555 ENOG4105CAQ asparagine synthetase C3496_14575 ENOG4105PGM cation diffusion facilitator family transporter C3496_14585 ENOG4105DRR Transcriptional regulator, GntR family C3496_14590 ENOG4108UZ3 Transporter C3496_14595 ENOG4105CKI cobalamin synthesis protein C3496_14615 ENOG4105DFD Na H antiporter C3496_14620 ENOG4105VUF Transcriptional regulator C3496_14630 ENOG4105C9Q fumarate hydratase class II C3496_14650 ENOG4107QJQ Mate efflux family protein C3496_14660 ENOG4105EC3 peptidase S51, dipeptidase E C3496_14680 ENOG4107QIV Cytochrome c biogenesis protein C3496_14705 ENOG4106BRA Membrane C3496_14745 ENOG4105CJ1 ABC, transporter C3496_14765 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) C3496_14775 ENOG4108IJ0 Aspartate ammonia-lyase C3496_14780 ENOG4105C6K Malic enzyme C3496_14820 ENOG41067QW Transcriptional regulator C3496_14850 ENOG4105FVX C3496_14880 ENOG4105CSR polyphosphate kinase 2 C3496_14890 ENOG4105DXI Major Facilitator superfamily C3496_14900 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) C3496_14910 ENOG4105EU0 Major facilitator Superfamily C3496_14915 ENOG4105C6T cysteine synthase C3496_14935 ENOG4105C8J )-transporter C3496_14945 ENOG4105X5K response regulator receiver protein C3496_14950 ENOG4105H67 Protein of unknown function (DUF421) C3496_14975 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C3496_14980 ENOG4105CHR reductase C3496_14985 ENOG4105CM2 brancheD-chain amino acid aminotransferase C3496_14990 ENOG4105C7K acetolactate synthase C3496_15000 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase C3496_15010 ENOG4105C7B Threonine dehydratase C3496_15035 ENOG4105C6X Major Facilitator C3496_15040 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b C3496_15050 ENOG4105DY9 regulatoR C3496_15055 ENOG4105CYC Transferase C3496_15075 ENOG4105F6J Alpha beta hydrolase fold C3496_15115 ENOG41068WN C3496_15140 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) C3496_15145 ENOG4105C72 UPF0176 protein C3496_15155 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) C3496_15160 ENOG4105C0X amino acid C3496_15195 ENOG4105KKX ATPase associated with various cellular activities aaa_5 C3496_15205 ENOG4105DEG Vwa containing coxe family protein C3496_15230 ENOG4107RHR regulatoR C3496_15240 ENOG4105D9N nucleoside C3496_15245 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) C3496_15285 ENOG4107R16 Multicopper oxidase C3496_15355 ENOG4108T5E Copper resistance protein C3496_15360 ENOG4105KTB nuclear export factor GLE1 C3496_15370 ENOG4107RT3 EamA-like transporter family C3496_15375 ENOG4105GZI Transcriptional regulator C3496_15380 ENOG4108Z40 Transcriptional regulator C3496_15385 ENOG4107ZXU DSBA oxidoreductase C3496_15390 ENOG4108TVJ Nitroreductase C3496_15400 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C3496_15405 ENOG4106F5Q Membrane C3496_15415 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C3496_15430 ENOG4105CKI cobalamin synthesis protein C3496_15445 ENOG4108Z7G MaoC domain protein dehydratase C3496_15450 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C3496_15465 ENOG4105C0Z ABC transporter C3496_15470 ENOG4108IV0 ABC, transporter C3496_15475 ENOG4105C32 Amino acid ABC transporter (Permease) C3496_15485 ENOG4105EGI Transcriptional regulator C3496_15515 ENOG4105C4M (Ubiquinol oxidase) subunit I C3496_15520 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C3496_15525 ENOG4108JJ9 ABC, transporter C3496_15530 ENOG4108JJ8 (ABC) transporter C3496_15550 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A C3496_15580 ENOG4105BZ1 (ABC) transporter C3496_15585 ENOG4105EFI regulatoR C3496_15590 ENOG4105BZU Histidine kinase C3496_15610 ENOG41075D4 Aminoglycoside 6-adenylyltransferase C3496_15615 ENOG4108ZJ4 polysaccharide deacetylase C3496_15640 ENOG4105D6E homoserine dehydrogenase C3496_15665 ENOG4108KGH TRANSCRIPTIONal C3496_15675 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C3496_15680 ENOG4105BZU Histidine kinase C3496_15685 ENOG4107VMI polysaccharide deacetylase C3496_15695 ENOG4105KT7 mgtC SapB transporter C3496_15700 ENOG4105VRR gCN5-related N-acetyltransferase C3496_15710 ENOG4105DUU IucA IucC family protein C3496_15715 ENOG4105CEY Amp-dependent synthetase and ligase C3496_15730 ENOG4108WBH protein TIM barrel C3496_15735 ENOG4105YWU small acid-soluble spore protein C3496_15745 ENOG4108ZUB Lysine exporter protein (Lyse ygga) C3496_15750 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C3496_15800 ENOG4105KRN Transcriptional regulator, abrb family C3496_15810 ENOG4105YVS arsR family transcriptional regulator C3496_15815 ENOG4105CPC Aldo Keto reductase C3496_15825 ENOG4107XZQ multidrug resistance protein C3496_15850 ENOG4105C8Q Methyl-accepting chemotaxis C3496_15870 ENOG4108K88 Membrane C3496_15875 ENOG4108WPJ Ferritin-like domain C3496_15890 ENOG4105DEN Luciferase family C3496_15910 ENOG4107QM2 Aldo Keto reductase C3496_15920 ENOG4105CKI cobalamin synthesis protein C3496_15930 ENOG4105DSE periplasmic solute binding protein C3496_15940 ENOG4105K4T epimerase C3496_15950 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C3496_15975 ENOG4105CVJ phosphoglycerate mutase C3496_15995 ENOG4107T5V SNARE associated Golgi C3496_16010 ENOG4108PJD permease C3496_16020 ENOG4108S4H thioesterase Superfamily protein C3496_16030 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C3496_16050 ENOG4105SXS Protein of unknown function (DUF456) C3496_16055 ENOG4105C37 (CBS) domain C3496_16075 ENOG4108Z7R Chaperone CsaA C3496_16095 ENOG4108ZRV stage ii sporulation protein p C3496_16105 ENOG4108VXD carboxy-peptidase C3496_16115 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C3496_16135 ENOG4105EFA 4-hydroxyphenylacetate C3496_16145 ENOG4105U1N riboflavin C3496_16160 ENOG4105KME endoribonuclease L-psp C3496_16190 ENOG41069HH 4-oxalocrotonate tautomerase C3496_16200 ENOG4108X4Q Hydrolase C3496_16210 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C3496_16215 ENOG4107UWY Methyltransferase C3496_16230 ENOG41087PP glycosyltransferase MGT family C3496_16235 ENOG4108JYZ YitT family C3496_16240 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C3496_16270 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) C3496_16405 ENOG4108NE4 C3496_16465 ENOG4105KBJ sporulation protein ytfj C3496_16490 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) C3496_16510 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) C3496_16515 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily C3496_16525 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein C3496_16530 ENOG4105EMN RNA polymerase sigma factor C3496_16555 ENOG4105CNW domain protein C3496_16575 ENOG4108V06 Glutathione peroxidase C3496_16590 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C3496_16610 ENOG4108IUE nitrate reductase beta subunit C3496_16615 ENOG4105R3A Nitrate reductase C3496_16625 ENOG4107V6Q Cyclic nucleotide-binding domain C3496_16630 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C3496_16635 ENOG4105D06 uba thif-type nad fad binding protein C3496_16640 ENOG4105CVM Molybdenum cofactor synthesis domain protein C3496_16645 ENOG4108ZAF Molybdopterin C3496_16675 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein C3496_16680 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein C3496_16685 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C3496_16690 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit C3496_16695 ENOG4108IFG nitrite reductase, (NAD(P)H) C3496_16700 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) C3496_16735 ENOG4105MCT stage V sporulation protein S C3496_16785 ENOG4105C5H ABC transporter C3496_16800 ENOG4108UUM single-stranded DNA-binding protein C3496_16820 ENOG4107YX5 Pfam:DUF548 C3496_16875 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) C3496_16885 ENOG4105C5S asparaginyl-tRNA synthetase C3496_16905 ENOG4105EC2 ftsk spoIIIe C3496_17050 ENOG4105C8J )-transporter C3496_17070 ENOG4107XGZ Hydrolase C3496_17075 ENOG4105CY2 Citrate transporter C3496_17080 ENOG4105C0A alcohol dehydrogenase C3496_17095 ENOG4105KD7 acetyltransferase C3496_17100 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase C3496_17125 ENOG4108YZS Had-superfamily hydrolase, subfamily ia, variant 1 C3496_17145 ENOG4107UQD Hydrolyzes N-terminal residues in D-amino acid- containing peptides (By similarity) C3496_17160 ENOG4107RVG penicillin-binding protein C3496_17170 ENOG4105E9Q Acyl-transferase C3496_17175 ENOG4108UT2 hemolysin iii C3496_17185 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) C3496_17200 ENOG4108RCR degv family C3496_17210 ENOG4108KF3 Electron transport protein SCO1 SenC C3496_17215 ENOG4107Y70 Heat shock protein C3496_17220 ENOG4105CAQ asparagine synthetase C3496_17240 ENOG4108MES Periplasmic binding protein C3496_17245 ENOG4105F0I Aminotransferase C3496_17270 ENOG4107Y70 Heat shock protein C3496_17275 ENOG4105D8X mechanosensitive ion channel C3496_17280 ENOG4105BZU Histidine kinase C3496_17285 ENOG4105WH1 Two component transcriptional regulator luxr family C3496_17290 ENOG4106KNT transcriptional regulator C3496_17350 ENOG4108IJ8 ABC transporter C3496_17355 ENOG4105E90 ABC transporter C3496_17390 ENOG4105C37 (CBS) domain C3496_17420 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C3496_17435 ENOG4107S4Y M20 DapE family protein YgeY C3496_17440 ENOG4108TSC N-acetyltransferase C3496_17445 ENOG4108JUB Transcriptional regulator C3496_17455 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein C3496_17495 ENOG4108N23 SpoOM-related protein C3496_17500 ENOG410841Q phosphoesterase PA-phosphatase related protein C3496_17510 ENOG4105SZ6 Thioredoxin C3496_17590 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C3496_17635 ENOG4105BZ4 penicillin-binding protein C3496_17645 ENOG4105CZM Major Facilitator C3496_17650 ENOG4105W8X HesB YadR YfhF-family protein C3496_17660 ENOG4105DXD 2-methylcitrate dehydratase C3496_17665 ENOG4105CR4 methylisocitrate lyase C3496_17670 ENOG4105C1G acyl-Coa dehydrogenase C3496_17675 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C3496_17685 ENOG4105N14 lysine exporter protein LysE YggA C3496_17690 ENOG4105E39 Enoyl-CoA hydratase C3496_17705 ENOG4107RFY SbcCD D subunit C3496_17740 ENOG4105FCD Major Facilitator C3496_17750 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase C3496_17755 ENOG4105E4F Isochorismate synthase C3496_17760 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase C3496_17765 ENOG4105WQI isochorismatase C3496_17770 ENOG4105CEY Amp-dependent synthetase and ligase C3496_17775 ENOG4105WQT MbtH domain protein C3496_17780 ENOG4105C0R drug resistance transporter emrb qaca subfamily C3496_17795 ENOG4105K70 DNA-binding protein C3496_17815 ENOG4105BZG amino acid carrier protein C3496_17835 ENOG4105FE9 pseudouridine synthase C3496_17840 ENOG4105C22 threonyL-tRNA synthetase C3496_17845 ENOG4105C19 ABC transporter C3496_17860 ENOG4107SKW Inherit from COG: Alpha beta hydrolase C3496_17910 ENOG41081I9 integral membrane protein C3496_17935 ENOG4105EYF MMPL domain protein C3496_17960 ENOG4105WCN acetyltransferase C3496_17985 ENOG4105C1Q protoporphyrinogen oxidase C3496_18000 ENOG41068WN C3496_18010 ENOG4105VEQ Cold shock protein C3496_18035 ENOG410667J hydrolase C3496_18045 ENOG4107V2S Transcriptional regulator C3496_18050 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) C3496_18065 ENOG4105DND Transcriptional regulator C3496_18070 ENOG4108RPX mosc domain containing protein C3496_18085 ENOG4105BZ1 (ABC) transporter C3496_18090 ENOG4105BZ1 (ABC) transporter C3496_18110 ENOG4108JCI Transcriptional regulator C3496_18140 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) C3496_18155 ENOG4108KPJ rna polymerase sigma factor C3496_18185 ENOG4105F32 YngK protein C3496_18215 ENOG4105RD7 BadF BadG BcrA BcrD C3496_18225 ENOG4107STF Involved in phosphonate degradation (By similarity) C3496_18265 ENOG4108JMX Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) C3496_18280 ENOG4105C1J atp-dependent rna helicase C3496_18295 ENOG4108RZE Tetr family transcriptional regulator C3496_18315 ENOG41088CC tellurite resistance protein tehB C3496_18325 ENOG4107RA9 decarboxylase C3496_18330 ENOG41090HR transcriptional regulator C3496_18360 ENOG4105CIN aminoacyl-histidine dipeptidase C3496_18375 ENOG4105EQK -acetyltransferase C3496_18385 ENOG4107RVG penicillin-binding protein C3496_18400 ENOG4107RF6 penicillin-binding protein C3496_18405 ENOG4107RF6 penicillin-binding protein C3496_18420 ENOG4105ETE Transcriptional regulator (LacI family C3496_18425 ENOG4105IE8 Alpha-ketoglutarate permease C3496_18430 ENOG4105CK5 oxidoreductase C3496_18455 ENOG4105D2N Aldolase C3496_18460 ENOG4105DH8 myo-inositol catabolism C3496_18490 ENOG4105EXC Acyl-transferase C3496_18545 ENOG4105BZU Histidine kinase C3496_18555 ENOG4105CZV ABC transporter C3496_18600 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C3496_18655 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C3496_18685 ENOG4105CJ1 ABC, transporter C3496_18695 ENOG4107Z3H Transcriptional regulator, TetR family C3496_18715 ENOG4105C1G acyl-Coa dehydrogenase C3496_18720 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C3496_18725 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit C3496_18730 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase C3496_18735 ENOG4105E39 Enoyl-CoA hydratase C3496_18740 ENOG4107QX3 carboxylase C3496_18745 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C3496_18755 ENOG4105WCN acetyltransferase C3496_18760 ENOG4105DBI uridine monophosphokinase C3496_18790 ENOG4105T9C HD domain C3496_18800 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) C3496_18805 ENOG4108RYK Nad-dependent epimerase dehydratase C3496_18825 ENOG41075H3 AraC family transcriptional regulator C3496_18890 ENOG41089UC methyltransferase, type 11 C3496_18905 ENOG4105CUV Homoserine Kinase C3496_18940 ENOG4105CPQ Dehydrogenase C3496_18945 ENOG410900G Protein of unknown function (DUF421) C3496_18960 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein C3496_18970 ENOG4105DK7 lysyl-tRNA synthetase C3496_19040 ENOG4105D6E homoserine dehydrogenase C3496_19055 ENOG4105ETU transcriptional activator (TenA C3496_19190 ENOG410667J hydrolase C3496_19200 ENOG4105BZU Histidine kinase C3496_19205 ENOG4107RF6 penicillin-binding protein C3496_19240 ENOG4108HGU Histidine kinase C3496_19250 ENOG4105RHY Pfam:UPF0157 C3496_19255 ENOG4105CB2 alcohol dehydrogenase C3496_19260 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase C3496_19265 ENOG4105CJN penicillin-binding protein C3496_19270 ENOG4108IG5 Transcriptional regulator C3496_19325 ENOG4108V4B ThiJ pfpI C3496_19350 ENOG4107TXC Transcriptional regulator C3496_19360 ENOG4107Y80 Major Facilitator superfamily C3496_19380 ENOG4107VXM glycerophosphoryl diester phosphodiesterase C3496_19405 ENOG4107Y9U Membrane C3496_19435 ENOG4105FCD Major Facilitator C3496_19450 ENOG4105E09 nadh pyrophosphatase C3496_19455 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) C3496_19460 ENOG4108Z4K mutator MutT protein C3496_19495 ENOG4108XI2 Domain of unknown function (DUF1963) C3496_19515 ENOG4108NRW Phospholipase, patatin family C3496_19520 ENOG4105KWG Pfam:DUF1696 C3496_19555 ENOG4105PKS Excinuclease abc c subunit domain protein C3496_19600 ENOG4107VFR oxidoreductase C3496_19620 ENOG4105PAD Hydrolase C3496_19650 ENOG4108IUM Glycogen debranching enzyme C3496_19675 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) C3496_19680 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) C3496_19690 ENOG4105FDR Membrane C3496_19750 ENOG4105MSI germination protein ypeb C3496_19785 ENOG4107Z3H Transcriptional regulator, TetR family C3496_19820 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family C3496_19830 ENOG4108MK9 spermidine N(1)-acetyltransferase C3496_19835 ENOG4105E98 transcriptional regulator DeoR family C3496_19860 ENOG4107QKR Dehydrogenase C3496_19870 ENOG4107RUY (E1 component), alpha subunit C3496_19880 ENOG4105E1F short-chain dehydrogenase reductase C3496_19885 ENOG4105RHY Pfam:UPF0157 C3496_19920 ENOG4107SQ8 Glycine betaine C3496_19925 ENOG4108IJ7 Glycine betaine C3496_19950 ENOG4105E66 phosphoriboisomerase A C3496_19955 ENOG41082BV acetyltransferase C3496_19960 ENOG4108M1A Chitin-binding protein C3496_19965 ENOG41087PP glycosyltransferase MGT family C3496_19990 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) C3496_20010 ENOG4108Z7F N-acetyltransferase C3496_20030 ENOG4105EEM helicase C3496_20050 ENOG4105C9U ATP-dependent DNA helicase RecQ C3496_20105 ENOG4108M1A Chitin-binding protein C3496_20125 ENOG4105BZG amino acid carrier protein C3496_20130 ENOG4105C26 Dehydrogenase C3496_20135 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C3496_20140 ENOG4105CTU Proline racemase C3496_20145 ENOG4105CTU Proline racemase C3496_20150 ENOG41080HI glycine oxidase C3496_20160 ENOG4107KMQ bfd domain protein (2fe-2s)-binding domain protein C3496_20190 ENOG4107T5V SNARE associated Golgi C3496_20205 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD C3496_20225 ENOG4105DTQ mandelate racemase muconate lactonizing C3496_20275 ENOG4105GYP Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity) C3496_20280 ENOG4105BZU Histidine kinase C3496_20285 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3496_20315 ENOG4105DPN Oligoendopeptidase f C3496_20320 ENOG4105DVH amino acid C3496_20340 ENOG4105EPR degv family C3496_20390 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) C3496_20395 ENOG4106K7D Major facilitator family transporter C3496_20415 ENOG4107BMA Transglycosylase associated protein C3496_20430 ENOG41089UC methyltransferase, type 11 C3496_20470 ENOG4105CHM Aminotransferase C3496_20485 ENOG4108ZMI UPF0477 protein C3496_20500 ENOG4105DVE abc transporter atp-binding protein C3496_20555 ENOG4105C02 permease C3496_20570 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) C3496_20575 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component C3496_20580 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein C3496_20615 ENOG4108AQF aminoglycoside N(3)-acetyltransferase C3496_20665 ENOG4107VC0 DNA alkylation repair enzyme C3496_20670 ENOG4107VMI polysaccharide deacetylase C3496_20675 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC C3496_20685 ENOG4106ETB IIa component C3496_20690 ENOG4108ZCF integral membrane protein C3496_20695 ENOG4105E0M Sulfatase C3496_20705 ENOG4105C5H ABC transporter C3496_20715 ENOG4105EYF MMPL domain protein C3496_20720 ENOG41082JN Transcriptional regulator C3496_20755 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase C3496_20795 ENOG41069ER domain protein C3496_20805 ENOG4105CY2 Citrate transporter C3496_20810 ENOG4105E39 Enoyl-CoA hydratase C3496_20815 ENOG4105J5T Amp-dependent synthetase and ligase C3496_20820 ENOG4108JUB Transcriptional regulator C3496_20835 ENOG4105D4B ABC, transporter C3496_20845 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane C3496_20855 ENOG4105DKT Transcriptional regulator C3496_20860 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) C3496_20870 ENOG41061GT Aldolase C3496_20895 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) C3496_20925 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) C3496_20935 ENOG4105II7 pyrroline-5-carboxylate reductase C3496_20955 ENOG4107258 Transcriptional regulator C3496_20965 ENOG4105E0Y RtcB Protein C3496_20970 ENOG4105ECK Fatty Acid Desaturase C3496_20975 ENOG4105G6Z alkaline phosphatase C3496_20985 ENOG4105VMP Transcriptional regulator C3496_21000 ENOG41090T1 Membrane C3496_21010 ENOG4108WCX response regulator C3496_21020 ENOG41068WN C3496_21050 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C3496_21095 ENOG4105CKK Glycosyl transferase, family 2 C3496_21105 ENOG4105C8Y Acetylornithine aminotransferase C3496_21170 ENOG4108TVJ Nitroreductase C3496_21175 ENOG4105FS7 Transcriptional regulator C3496_21195 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) C3496_21200 ENOG4105WEC Molybdate metabolism regulator C3496_21210 ENOG4105C19 ABC transporter C3496_21235 ENOG4108DMH HTH_ARAC C3496_21240 ENOG4108XET gCN5-related N-acetyltransferase C3496_21265 ENOG4107XJU UPF0178 protein C3496_21305 ENOG410635A Membrane C3496_21310 ENOG4105KNA -acetyltransferase C3496_21315 ENOG4108IQI permease C3496_21325 ENOG4105F1N DNA alkylation repair C3496_21360 ENOG4107RF6 penicillin-binding protein C3496_21400 ENOG4105P4J Allophanate hydrolase, subunit 1 C3496_21405 ENOG4107258 Transcriptional regulator C3496_21415 ENOG4106N3A copper homeostasis protein cutc C3496_21420 ENOG4108ZRV stage ii sporulation protein p C3496_21425 ENOG4108ZHR arsR family transcriptional regulator C3496_21440 ENOG4105FDT acyl-CoA dehydrogenase C3496_21455 ENOG4105DWD nucleoside recognition domain protein C3496_21480 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) C3496_21545 ENOG4105E2A Dehydrogenase C3496_21555 ENOG4108IJ0 Aspartate ammonia-lyase C3496_21560 ENOG4105HDK L-asparaginase C3496_21565 ENOG4108IMY Transcriptional regulator C3496_21570 ENOG4105DQ6 Transposase C3496_21575 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) C3496_21580 ENOG4105CUB amino acid C3496_21585 ENOG4105II7 pyrroline-5-carboxylate reductase C3496_21640 ENOG4105CGH 5'-nucleotidase C3496_21645 ENOG4105CH6 catalase C3496_21655 ENOG4105CHJ isochorismatase hydrolase C3496_21750 ENOG4108606 TspO/MBR family C3496_21755 ENOG4105CVP deoxyribo-dipyrimidine photolyase C3496_21770 ENOG4108TWJ NADH dehydrogenase subunit 5 C3496_21775 ENOG4105GPN Uncharacterized conserved protein (DUF2294) C3496_21795 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase C3496_21800 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) C3496_21810 ENOG4105C19 ABC transporter C3496_21825 ENOG4108NEV two component transcriptional regulator, LytTR family C3496_21865 ENOG4105D6J arsenicaL-resistance protein C3496_21870 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase C3496_21875 ENOG41085FC arsR family transcriptional regulator C3496_21890 ENOG4105F7F Chaperone C3496_21905 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C3496_21985 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C3496_21995 ENOG4105C0R drug resistance transporter emrb qaca subfamily C3496_22015 ENOG4105IIP Membrane C3496_22055 ENOG4105K6H D-cysteine desulfhydrase C3496_22080 ENOG4108NNI Beta-lactamase domain-containing protein C3496_22085 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase C3496_22095 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C3496_22100 ENOG4105JQZ Methyltransferase C3496_22120 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) C3496_22135 ENOG4105BZU Histidine kinase C3496_22145 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) C3496_22150 ENOG4105DJB Major Facilitator Superfamily C3496_22155 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) C3496_22160 ENOG4107QR9 Iron-sulfur cluster binding protein C3496_22170 ENOG4106P55 Transcriptional regulator C3496_22190 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A C3496_22210 ENOG4108JQ1 Dehydrogenase C3496_22230 ENOG41082W1 Cupin 2, conserved barrel domain protein C3496_22240 ENOG410874W AraC family transcriptional regulator C3496_22255 ENOG4108IBT Inherit from COG: transposase C3496_22280 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase C3496_22320 ENOG4108ISG Major Facilitator C3496_22335 ENOG4107MII Sugar-specific transcriptional regulator TrmB C3496_22340 ENOG4105CZM Major Facilitator C3496_22350 ENOG4105RXJ C3496_22355 ENOG4105KPY Small multidrug resistance protein C3496_22360 ENOG4105KBX Transcriptional regulator, TetR family C3496_22370 ENOG4105CRW Short chain fatty acid transporter C3496_22380 ENOG4105DYS nad(p)h dehydrogenase (quinone) C3496_22415 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) C3496_22455 ENOG4107TXC Transcriptional regulator C3496_22505 ENOG4108Z66 YbaK ebsC protein C3496_22520 ENOG4105KVH Transcriptional regulator C3496_22525 ENOG4108RCM Nitroreductase C3496_22550 ENOG4108PSK reductase C3496_22560 ENOG4105CJ1 ABC, transporter C3496_22630 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase C3496_22635 ENOG4105DKQ ROK family C3496_22640 ENOG4106UW1 Major Facilitator superfamily C3496_22645 ENOG4108UW5 maltose o-acetyltransferase C3496_22655 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C3496_22665 ENOG4105C31 Tryptophanyl-tRNA synthetase C3496_22695 ENOG4105DMQ Methyltransferase C3496_22735 ENOG4105C37 (CBS) domain C3496_22750 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase C3496_22755 ENOG4105FAW cDP-glucose 4,6-dehydratase C3496_22785 ENOG4105DDN Pentapeptide repeat-containing protein C3496_22790 ENOG4105XDF Protein of unknown function (DUF1272) C3496_22795 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) C3496_22800 ENOG4105CMG Carbohydrate kinase C3496_22805 ENOG4105C6Z Gluconate C3496_22810 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) C3496_22825 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase C3496_22830 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase C3496_22835 ENOG4105CIS alcohol dehydrogenase C3496_22840 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone C3496_22860 ENOG4105EWI Short-chain dehydrogenase reductase Sdr C3496_22865 ENOG4105D4Y metalloprotease C3496_22875 ENOG4105C8Q Methyl-accepting chemotaxis C3496_22880 ENOG4108UX3 '-nucleotidase C3496_22885 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) C3496_22890 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) C3496_22895 ENOG4105KVH Transcriptional regulator C3496_22920 ENOG4105C44 Serine transporter C3496_22965 ENOG4105KVH Transcriptional regulator C3496_22970 ENOG4108TZY GntR Family Transcriptional Regulator C3496_22975 ENOG4105D9R oxidoreductase C3496_22980 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase C3496_22985 ENOG4105KVH Transcriptional regulator C3496_22990 ENOG4105KVH Transcriptional regulator C3496_23030 ENOG4105JAB phenazine biosynthesis protein, phzf family C3496_23040 ENOG4105CHR reductase C3496_23050 ENOG4105KNA -acetyltransferase C3496_23060 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein C3496_23065 ENOG4105KVH Transcriptional regulator C3496_23075 ENOG4108ZJ4 polysaccharide deacetylase C3496_23120 ENOG4105KAF membrAne C3496_23150 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) C3496_23170 ENOG4107YXZ hydrolase, family 25 C3496_23205 ENOG4105H3G oxidoreductase C3496_23250 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C3496_23290 ENOG4105CIS alcohol dehydrogenase C3496_23330 ENOG4108TN2 lmbE family C3496_23340 ENOG4107R3E Citrate transporter C3496_23350 ENOG4108MES Periplasmic binding protein C3496_23355 ENOG4105EHG Permease protein C3496_23360 ENOG4105DQ5 transport system permease protein C3496_23365 ENOG4105NX3 Membrane C3496_23370 ENOG4107ZY0 Phenazine biosynthesis-like protein C3496_23395 ENOG4107CUJ Protein of unknown function (DUF2690) C3496_23405 ENOG4107V2S Transcriptional regulator C3496_23415 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) C3496_23430 ENOG4105C98 muts2 protein C3496_23440 ENOG4105E5K Alpha-amylase C3496_23445 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase C3496_23450 ENOG4105DPN Oligoendopeptidase f C3496_23455 ENOG4108A04 Beta-lactamase C3496_23480 ENOG4107VXM glycerophosphoryl diester phosphodiesterase C3496_23505 ENOG41082BM Transcriptional regulator, arsr family C3496_23510 ENOG4105CIS alcohol dehydrogenase C3496_23520 ENOG4107JM4 Tetratricopeptide repeat C3496_23545 ENOG4105C09 Bile acid C3496_23550 ENOG4105CQB FAD linked oxidase domain protein C3496_23580 ENOG4108UT6 Transferase hexapeptide repeat containing protein C3496_23590 ENOG4105K64 Glycosyl transferase, family 2 C3496_23595 ENOG4105E39 Enoyl-CoA hydratase C3496_23605 ENOG4105KT7 mgtC SapB transporter C3496_23620 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase C3496_23625 ENOG41073R8 VanW family C3496_23635 ENOG4108R1P C3496_23655 ENOG4105VEQ Cold shock protein C3496_23695 ENOG410904N short-chain dehydrogenase reductase C3496_23705 ENOG4106IQC argininosuccinate lyase C3496_23720 ENOG4108IA2 Sodium pantothenate symporter C3496_23730 ENOG4105C26 Dehydrogenase C3496_23735 ENOG4105CHR reductase C3496_23745 ENOG4105EWU Squalene--hopene cyclase C3496_23755 ENOG4105FR1 rard protein C3496_23760 ENOG410696E Membrane C3496_23775 ENOG4105D1F ATP-binding protein C3496_23785 ENOG4108ZAF Molybdopterin C3496_23790 ENOG4105CVM Molybdenum cofactor synthesis domain protein C3496_23795 ENOG4105D06 uba thif-type nad fad binding protein C3496_23800 ENOG4105TMB Formate nitrite transporter C3496_23815 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) C3496_23820 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) C3496_23830 ENOG4108JB9 formate dehydrogenase C3496_23840 ENOG4105E1K spore germination protein C3496_23910 ENOG4107QJT sodium dicarboxylate symporter C3496_23915 ENOG4108KGH TRANSCRIPTIONal C3496_23925 ENOG4105EMN RNA polymerase sigma factor C3496_23940 ENOG4105CIG ABC transporter C3496_23950 ENOG4105D9R oxidoreductase C3496_23960 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C3496_23970 ENOG4105K4P CoA-binding domain protein C3496_23975 ENOG4105C0H protease C3496_23980 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C3496_23990 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase C3496_24000 ENOG4105W8X HesB YadR YfhF-family protein C3496_24030 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) C3496_24040 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C3496_24055 ENOG4108I0Z Aconitate hydratase C3496_24085 ENOG4105E5W Transporter C3496_24095 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C3496_24115 ENOG4107F3J Amp-dependent synthetase and ligase C3496_24120 ENOG4107ZYJ bioY protein C3496_24125 ENOG4105CEY Amp-dependent synthetase and ligase C3496_24140 ENOG4108IMY Transcriptional regulator C3496_24190 ENOG4107AYK membrAne C3496_24205 ENOG4105BZU Histidine kinase C3496_24210 ENOG4105FBA Phospholipase Carboxylesterase C3496_24215 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase C3496_24220 ENOG4105CK7 Sodium proline symporter C3496_24225 ENOG4105CBC glutamate synthase C3496_24230 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C3496_24235 ENOG4108VJ1 Transcriptional regulator (CarD family C3496_24240 ENOG4108903 Formimidoylglutamase C3496_24310 ENOG4107QIV Cytochrome c biogenesis protein C3496_24325 ENOG4105CH2 amidohydrolase C3496_24335 ENOG4105CJ1 ABC, transporter C3496_24345 ENOG4107RSM transcriptional regulator C3496_24355 ENOG41067MG lrgb family C3496_24395 ENOG4105BZ1 (ABC) transporter C3496_24400 ENOG4105BZ1 (ABC) transporter C3496_24445 ENOG4105CGH 5'-nucleotidase C3496_24455 ENOG4108SVB resolvase C3496_24475 ENOG4105K7K Transcriptional regulator C3496_24490 ENOG4105E4C Lytic transglycosylase catalytic C3496_24495 ENOG41065S2 pneumococcal vaccine antigen C3496_24530 ENOG4105C5F glutamine synthetase C3496_24535 ENOG4105KV4 Transcriptional regulator C3496_24540 ENOG4105CXI aluminum resistance protein C3496_24545 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) C3496_24550 ENOG4105EN6 Membrane C3496_24555 ENOG4106F1P AAA ATPase, central domain protein C3496_24585 ENOG41069ER domain protein C3496_24595 ENOG4105DM4 PTS System C3496_24600 ENOG4105DE4 1-phosphofructokinase C3496_24605 ENOG4105E98 transcriptional regulator DeoR family C3496_24610 ENOG4107QW4 alcohol dehydrogenase C3496_24615 ENOG4108SJC Membrane C3496_24630 ENOG4105C85 amino acid C3496_24655 ENOG4105TMB Formate nitrite transporter C3496_24660 ENOG4105K70 DNA-binding protein C3496_24670 ENOG4105C59 p-type ATPase C3496_24675 ENOG410681U heavy metal transport detoxification protein C3496_24680 ENOG4105VPX protein, conserved in bacteria C3496_24690 ENOG4105NIV Esterase C3496_24695 ENOG4105E0A ABC, transporter C3496_24715 ENOG4105CGK Exodeoxyribonuclease III C3496_24725 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C3496_24730 ENOG4105D03 DNA-3-methyladenine glycosylase II C3496_24760 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase C3496_24765 ENOG4105BZU Histidine kinase C3496_24795 ENOG4107TTQ Alpha beta hydrolase fold C3496_24800 ENOG4107YEI lmbE family C3496_24825 ENOG4105F0V Cell wall hydrolase C3496_24835 ENOG4105E0M Sulfatase C3496_24840 ENOG410890F Dynamin family C3496_24855 ENOG4105W8Z 4'-phosphopantetheinyl transferase C3496_24875 ENOG4108JA1 polyketide synthase C3496_24890 ENOG4105BZJ Electron transfer flavoprotein C3496_24895 ENOG4105C1G acyl-Coa dehydrogenase C3496_24910 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C3496_24935 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) C3496_24975 ENOG4105DQU oxidoreductase, subunit beta C3496_24980 ENOG4105DI2 Pyruvate flavodoxin ferredoxin oxidoreductase domain protein C3496_24985 ENOG4108IGT Dipeptidase C3496_24990 ENOG4105MCT stage V sporulation protein S C3496_24995 ENOG4105D48 metallophosphoesterase C3496_25020 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase C3496_25035 ENOG4105XZV Protein of unknown function (DUF3243) C3496_25040 ENOG4108RKS Short-chain dehydrogenase reductase Sdr C3496_25060 ENOG4105UIB (ABC) transporter C3496_25065 ENOG4108JQ9 ABC transporter C3496_25070 ENOG4105DIH basic membrane C3496_25075 ENOG4105FDP GntR family transcriptional regulator C3496_25085 ENOG4107QZI cell division protein FtsK C3496_25095 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit C3496_25110 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C3496_25120 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) C3496_25125 ENOG4108S0H Dipicolinic acid synthetase, b subunit C3496_25150 ENOG4105XSJ toxin secretion phage lysis holin C3496_25245 ENOG4105CDU Replicative dna helicase C3496_25280 ENOG4108IMY Transcriptional regulator C3496_25315 ENOG4105E35 Dipicolinate synthase subunit A C3496_25330 ENOG4105C1V Peptidase, M16 C3496_25350 ENOG4105DTN riboflavin biosynthesis protein ribF C3496_25365 ENOG4105W7A Protein of unknown function (DUF503) C3496_25375 ENOG4105VHM ribosomal protein C3496_25380 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination C3496_25385 ENOG4105CHV Transcription elongation factor NusA C3496_25395 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) C3496_25410 ENOG4105DZP Membrane-associated zinc metalloprotease C3496_25415 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) C3496_25420 ENOG4105KNE Phosphatidate cytidylyltransferase C3496_25465 ENOG4108HE4 integrase family C3496_25475 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) C3496_25480 ENOG4105C79 DNA protecting protein DprA C3496_25485 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha C3496_25500 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) C3496_25525 ENOG4105VB6 UPF0109 protein C3496_25545 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) C3496_25550 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) C3496_25565 ENOG4105CHR reductase C3496_25570 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C3496_25585 ENOG4105CB5 ATP-dependent DNA helicase recG C3496_25590 ENOG4105DP4 dak2 domain fusion protein ylov C3496_25595 ENOG4108ZAA Alkaline-shock protein C3496_25610 ENOG4105FJ0 thiamine C3496_25615 ENOG4105DJV ribulose-phosphate 3-epimerase C3496_25625 ENOG4105D9P serine threonine protein kinase C3496_25630 ENOG4108ZF3 Phosphatase C3496_25640 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B C3496_25650 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C3496_25655 ENOG4105C25 Primosomal protein n' C3496_25660 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase C3496_25680 ENOG4105DSJ YicC domain protein C3496_25690 ENOG4105F23 Fibronectin-binding protein C3496_25695 ENOG4105DC7 peptidase M24 C3496_25755 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain C3496_25780 ENOG4105C34 Pseudouridine synthase C3496_25805 ENOG4105DBK s4 domain protein C3496_25810 ENOG41067XK integral membrane protein C3496_25820 ENOG4105DFA alanine racemase domain protein C3496_25825 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase C3496_25830 ENOG4105WR5 sporulation protein, YlmC YmxH family C3496_25840 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3496_25850 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) C3496_25855 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) C3496_25860 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) C3496_25870 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) C3496_25875 ENOG4105CNI cell division protein FtsW C3496_25890 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) C3496_25895 ENOG4105CJN penicillin-binding protein C3496_25900 ENOG4105CJN penicillin-binding protein C3496_25905 ENOG41068DC Essential cell division protein (By similarity) C3496_25940 ENOG4105KNH Nucleic acid-binding protein C3496_25950 ENOG41063PX domain protein C3496_25955 ENOG4105D78 K07001 NTE family protein C3496_25960 ENOG4105H20 Sporulation integral membrane protein YlbJ C3496_25970 ENOG4106H78 methyltransferase C3496_25990 ENOG4107TB6 phosphoglycerate mutase C3496_26005 ENOG4106UY4 Inherit from COG: Scp-like extracellular C3496_26055 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) C3496_26065 ENOG4105CNI cell division protein FtsW C3496_26080 ENOG4108IAB Phoh family C3496_26100 ENOG4105QA2 C3496_26105 ENOG4105CI3 gtp-binding protein typa C3496_26115 ENOG4105ECY inositol monophosphatase C3496_26135 ENOG4105CXN decarboxylase C3496_26185 ENOG4105CPP Dehydrogenase, E1 component C3496_26200 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C3496_26205 ENOG4108X4Q Hydrolase C3496_26220 ENOG4105CN5 Metallo-Beta-Lactamase C3496_26225 ENOG4107ZYR domain protein C3496_26260 ENOG4108XRC Protein of unknown function (DUF458) C3496_26270 ENOG4107IN1 Protein of unknown function (DUF1797) C3496_26285 ENOG4105EPM Diguanylate phosphodiesterase C3496_26290 ENOG4105K6S Short-chain dehydrogenase reductase Sdr C3496_26310 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) C3496_26320 ENOG4105UIN C3496_26390 ENOG4108HGU Histidine kinase C3496_26400 ENOG4105CHM Aminotransferase C3496_26405 ENOG4105FKQ transcriptional regulator C3496_26410 ENOG4105EG2 ABC transporter, permease C3496_26420 ENOG4107FKK extracellular solute-binding protein family 1 C3496_26430 ENOG4105CG3 alpha amylase, catalytic region C3496_26480 ENOG4105CHU acetyl-coa acetyltransferase C3496_26515 ENOG4105K7K Transcriptional regulator C3496_26520 ENOG4105DTD Dehydrogenase C3496_26540 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase C3496_26580 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C3496_26590 ENOG4105BZU Histidine kinase C3496_26610 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) C3496_26625 ENOG4105CID antiterminator C3496_26635 ENOG4105FDP GntR family transcriptional regulator C3496_26645 ENOG4105CE4 GlcNAc 6-P deacetylase C3496_26690 ENOG4107ZE5 PPIases accelerate the folding of proteins C3496_26695 ENOG4105PTM secreted protein C3496_26700 ENOG4105J7I hydrolase C3496_26710 ENOG4105G6R Stage v sporulation protein ae C3496_26720 ENOG4105CZ3 stage V sporulation protein ad C3496_26725 ENOG41090VF Stage v sporulation protein ac C3496_26745 ENOG4105C8J )-transporter C3496_26750 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3496_26760 ENOG41082AN stage II sporulation protein C3496_26765 ENOG4105DZ1 carboxypeptidase C3496_26775 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family C3496_26780 ENOG4105DVE abc transporter atp-binding protein C3496_26815 ENOG4105D7N magnesium and cobalt transport protein CorA C3496_26840 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C3496_26850 ENOG4105I3K Ferric uptake regulator, Fur family C3496_26855 ENOG4105MZ9 stage II sporulation protein m C3496_26875 ENOG4105CPC Aldo Keto reductase C3496_26885 ENOG4105RHY Pfam:UPF0157 C3496_26905 ENOG4107SKW Inherit from COG: Alpha beta hydrolase C3496_26915 ENOG4105ETE Transcriptional regulator (LacI family C3496_26920 ENOG4108YM7 Gcn5-related n-acetyltransferase C3496_26940 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) C3496_26945 ENOG4108R6K riboflavin synthase, subunit alpha C3496_26965 ENOG4107VUU Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) C3496_26970 ENOG41090JN Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) C3496_26975 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) C3496_26990 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C3496_27005 ENOG4105DFD Na H antiporter C3496_27010 ENOG4105CGH 5'-nucleotidase C3496_27065 ENOG4108IXY short-chain dehydrogenase reductase C3496_27070 ENOG41069FQ Metallo-beta-lactamase superfamily C3496_27075 ENOG4105II7 pyrroline-5-carboxylate reductase C3496_27080 ENOG4105EJQ L-serine dehydratase C3496_27120 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) C3496_27125 ENOG4105D9U N-acetyltransferase C3496_27140 ENOG4108VZI ErfK ybiS ycfS ynhG family protein C3496_27145 ENOG4108QEG Membrane C3496_27150 ENOG4105CDA abc transporter atp-binding protein C3496_27155 ENOG4105E5Q amino acid AbC transporter C3496_27160 ENOG4108HW3 (ABC) transporter C3496_27175 ENOG4105G7B Protein of unknown function (DUF2992) C3496_27185 ENOG4108QY0 Membrane C3496_27200 ENOG4105C7S Dehydrogenase C3496_27205 ENOG4105CPP Dehydrogenase, E1 component C3496_27225 ENOG4107RDP Dehydrogenase C3496_27240 ENOG4108JUB Transcriptional regulator C3496_27245 ENOG4106CCJ Protein of unknown function (DUF2627) C3496_27250 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C3496_27265 ENOG4107QQR Sporulation C3496_27275 ENOG4105S1Z Stage IV sporulation protein B C3496_27280 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) C3496_27290 ENOG4105DX0 Hemolysin A C3496_27300 ENOG4105CTB Polyprenyl synthetase C3496_27325 ENOG4108ZSR alkaline shock protein C3496_27330 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C3496_27355 ENOG410644B Stage III sporulation protein af C3496_27365 ENOG4105KQ4 Stage iii sporulation protein ad C3496_27370 ENOG4108CQH stage III sporulation protein AC C3496_27375 ENOG4105KR5 Stage iii sporulation protein C3496_27380 ENOG4105CD2 stage iii sporulation protein aa C3496_27405 ENOG4105DC7 peptidase M24 C3496_27420 ENOG4105CBJ Metal-dependent enzyme C3496_27430 ENOG4107YBY Hydrolase C3496_27465 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) C3496_27470 ENOG4105WZW rhodanese family C3496_27490 ENOG41080TC multidrug resistance protein C3496_27530 ENOG4105CJ1 ABC, transporter C3496_27535 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family C3496_27570 ENOG4105C0D helicase C3496_27695 ENOG4105C3R Methionine synthase C3496_27705 ENOG4105C28 cystathionine C3496_27710 ENOG4105C28 cystathionine C3496_27730 ENOG4105C5X domain protein C3496_27740 ENOG4105DKQ ROK family C3496_27750 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase C3496_27765 ENOG4108UTW Plays a role in the regulation of phosphate uptake C3496_27770 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C3496_27775 ENOG4105E2Z phosphate ABC transporter (Permease C3496_27780 ENOG4105C8U phosphate abc transporter C3496_27785 ENOG4105PWN phosphate abc transporter C3496_27790 ENOG4107RF6 penicillin-binding protein C3496_27800 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C3496_27825 ENOG4105N80 Ferric uptake regulator, Fur family C3496_27835 ENOG4105FDK ABC transporter C3496_27840 ENOG4108JYZ YitT family C3496_27845 ENOG41069ZM Protein of unknown function (DUF2624) C3496_27870 ENOG4105EGD dinuclear metal center protein, YbgI family C3496_27885 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3496_27890 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) C3496_27925 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) C3496_27930 ENOG4105KG3 cytidine deaminase C3496_27935 ENOG4107YR5 Diacylglycerol kinase C3496_27945 ENOG4105CTJ Metal Dependent Phosphohydrolase C3496_27950 ENOG4105C9A Phoh family C3496_27965 ENOG41068P3 sporulation protein YqfC C3496_27970 ENOG4105KTH gatB Yqey C3496_27985 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C3496_27990 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) C3496_28010 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ C3496_28020 ENOG4105CSA Coproporphyrinogen iii oxidase C3496_28025 ENOG4105KVH Transcriptional regulator C3496_28050 ENOG4105TQK DNA polymerase iii, delta' subunit C3496_28060 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 C3496_28065 ENOG4108UK2 deaminase C3496_28070 ENOG4105KQC Competence protein C3496_28080 ENOG4105DXX methyltransferase C3496_28090 ENOG4108WF2 Metal Dependent Phosphohydrolase C3496_28100 ENOG410812S Rna-binding protein C3496_28110 ENOG4105CQW ribosome biogenesis GTPase YqeH C3496_28115 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase C3496_28130 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C3496_28150 ENOG4108TVJ Nitroreductase C3496_28165 ENOG4105G6Z alkaline phosphatase C3496_28175 ENOG4108MUZ hydrolase C3496_28210 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin C3496_28215 ENOG4105MIR Phenylalanine 4-monooxygenase C3496_28225 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase C3496_28265 ENOG4105S6R Iron-hydroxamate transporter permease subunit C3496_28270 ENOG4108V5C ABC transporter C3496_28280 ENOG4108EKI Dehydrogenase C3496_28285 ENOG4105C28 cystathionine C3496_28315 ENOG4107XRG penicillin-binding protein C3496_28335 ENOG4105CFP Peptidase U32 C3496_28340 ENOG4105XYU peptidase (U32 family) C3496_28345 ENOG4108VQJ O-methyltransferase C3496_28350 ENOG4105HHA aminodeoxychorismate lyase C3496_28380 ENOG4105C02 permease C3496_28395 ENOG41060CR C3496_28400 ENOG4105C7H Helicase, RecD TraA family C3496_28415 ENOG4105C3J Cysteine desulfurase C3496_28425 ENOG4105D1H recombination factor protein RarA C3496_28430 ENOG4108VCI transcription factor, rsfa family C3496_28440 ENOG4105CUZ uba thif-type nad fad binding protein C3496_28450 ENOG4105CUT histidyl-tRNA synthetase C3496_28470 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)