locus-tag class description AW03_000010 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) AW03_000020 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AW03_000040 ENOG410848D S4 domain protein YaaA AW03_000070 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AW03_000080 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AW03_000110 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AW03_000130 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) AW03_000140 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) AW03_000150 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) AW03_000160 ENOG4105ZMH deoxynucleoside kinase AW03_000180 ENOG4105VRS hydrolase family 18 AW03_000190 ENOG4105GTG Isochorismatase AW03_000200 ENOG4108Z6B deaminase AW03_000210 ENOG4105C6E dna polymerase iii AW03_000220 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) AW03_000230 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) AW03_000250 ENOG41067KS pro-sigma K processing AW03_000280 ENOG4105CDW Resistance protein AW03_000290 ENOG4105CXN decarboxylase AW03_000300 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) AW03_000310 ENOG4105X0R protein from nitrogen regulatory protein P-II AW03_000330 ENOG4105XVJ Protein of unknown function (DUF327) AW03_000340 ENOG4105FA2 dna polymerase iii AW03_000350 ENOG4105MA4 psp1 domain protein AW03_000360 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) AW03_000370 ENOG41060K3 Methyltransferase AW03_000380 ENOG4105VC4 domain protein AW03_000390 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AW03_000400 ENOG4105KRN Transcriptional regulator, abrb family AW03_000410 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) AW03_000420 ENOG4105F8V Hydrolase, tatD family AW03_000430 ENOG41069ER domain protein AW03_000450 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) AW03_000460 ENOG4105XFA sporulation peptidase YabG AW03_000470 ENOG4105W42 Veg protein AW03_000480 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) AW03_000490 ENOG4105DFT pur operon repressor AW03_000500 ENOG4105KME endoribonuclease L-psp AW03_000510 ENOG4105K4W Could be involved in septation (By similarity) AW03_000520 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) AW03_000530 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AW03_000540 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) AW03_000550 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) AW03_000570 ENOG4108JA2 transcriptioN-repair coupling factor AW03_000580 ENOG4108M14 stage v sporulation protein t AW03_000600 ENOG4108IY2 MazG family AW03_000610 ENOG41082I2 s4 domain protein AW03_000620 ENOG4105VYY sporulation protein yabp AW03_000650 ENOG41060GV RNA binding s1 domain protein AW03_000690 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AW03_000700 ENOG4108UGV hypoxanthine phosphoribosyltransferase AW03_000710 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AW03_000730 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) AW03_000740 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase AW03_000750 ENOG4105C6T cysteine synthase AW03_000760 ENOG4105CRQ synthase (Component I) AW03_000770 ENOG4105DDQ anthranilate synthase AW03_000780 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 AW03_000790 ENOG4105EEI dihydropteroate synthase AW03_000800 ENOG4105KRF dihydroneopterin aldolase AW03_000810 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AW03_000830 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AW03_000840 ENOG4105CRK lysyL-tRNA synthetase AW03_000860 ENOG4108Z0C Uvrb UvrC protein AW03_000870 ENOG41066A3 ATP guanido phosphotransferase AW03_000890 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AW03_000900 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) AW03_000910 ENOG4105CTP PilT protein domain protein AW03_000920 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) AW03_000930 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) AW03_000940 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) AW03_000950 ENOG4105D7W serine acetyltransferase AW03_000960 ENOG4105C8N cysteinyl-tRNA synthetase AW03_000970 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) AW03_000990 ENOG4105C2N RNA methyltransferase TrmH family group 3 AW03_001000 ENOG4105M0M Tetracycline resistance protein AW03_001030 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AW03_001040 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) AW03_001060 ENOG4108VZM 50s ribosomal protein L10 AW03_001070 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) AW03_001080 ENOG4107Y49 methyltransferase AW03_001090 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AW03_001100 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AW03_001110 ENOG4105XPM ribosomal protein AW03_001120 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) AW03_001130 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) AW03_001140 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) AW03_001150 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) AW03_001160 ENOG4107SKW Inherit from COG: Alpha beta hydrolase AW03_001170 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) AW03_001180 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) AW03_001190 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AW03_001200 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AW03_001210 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity AW03_001220 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AW03_001230 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AW03_001240 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AW03_001250 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AW03_001260 ENOG41082SA 50s ribosomal protein l29 AW03_001270 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AW03_001280 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) AW03_001300 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits AW03_001320 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AW03_001330 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) AW03_001340 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) AW03_001350 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AW03_001360 ENOG4105VPB 50S ribosomal protein L30 AW03_001370 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) AW03_001380 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AW03_001400 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AW03_001410 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AW03_001430 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AW03_001450 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) AW03_001460 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AW03_001470 ENOG4108ZT0 50S ribosomal protein l17 AW03_001480 ENOG4108JJB ABC transporter AW03_001490 ENOG4108JJB ABC transporter AW03_001500 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) AW03_001510 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) AW03_001520 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) AW03_001530 ENOG4108UJD 30S ribosomal protein S9 AW03_001540 ENOG4108I0C methyltransferase AW03_001570 ENOG4105D1F ATP-binding protein AW03_001600 ENOG4108NMV polysaccharide deacetylase AW03_001610 ENOG4105CHH sulfate transporter AW03_001630 ENOG4108SA1 esterase AW03_001670 ENOG410874W AraC family transcriptional regulator AW03_001680 ENOG4105EHZ conserved protein UCP016719 AW03_001690 ENOG4105D17 glycoside hydrolase, family 3 domain protein AW03_001730 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate AW03_001750 ENOG4105EWC Purine nucleoside phosphorylase AW03_001770 ENOG4105EMN RNA polymerase sigma factor AW03_001790 ENOG4105C8B TIGR00159 family AW03_001800 ENOG4107U5W ybbr family AW03_001810 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AW03_001820 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AW03_001840 ENOG4108TWJ NADH dehydrogenase subunit 5 AW03_001880 ENOG4105GPN Uncharacterized conserved protein (DUF2294) AW03_001890 ENOG4105WAB arsR family transcriptional regulator AW03_001900 ENOG4108RWP Major Facilitator Superfamily protein AW03_001960 ENOG4105G0J serine threonine protein kinase AW03_001980 ENOG4106K80 AW03_002000 ENOG4106DDH Sporulation-specific SASP protein AW03_002020 ENOG4108HWY Beta-lactamase AW03_002030 ENOG4107E6A Cytochrome p-450 AW03_002050 ENOG4107QTZ amino acid AW03_002060 ENOG4107VXM glycerophosphoryl diester phosphodiesterase AW03_002070 ENOG4105CXY transporter AW03_002100 ENOG410645S MarR family Transcriptional regulator AW03_002110 ENOG4105DCM major facilitator superfamily AW03_002130 ENOG410631K Membrane AW03_002140 ENOG4106AXJ AraC family transcriptional regulator AW03_002150 ENOG41065RQ ADP-ribosylation crystallin J1 AW03_002160 ENOG4106BHF AW03_002180 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR AW03_002190 ENOG4108TCS Glutamyl endopeptidase AW03_002210 ENOG4108WC5 Alpha Beta Hydrolase Fold protein AW03_002220 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase AW03_002230 ENOG4107ZTW SNARE associated Golgi AW03_002270 ENOG4105C72 UPF0176 protein AW03_002290 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane AW03_002300 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) AW03_002310 ENOG4108X79 transcriptional regulator AW03_002330 ENOG4105CM2 brancheD-chain amino acid aminotransferase AW03_002340 ENOG4108IQI permease AW03_002350 ENOG4108J5H Homocysteine s-methyltransferase AW03_002380 ENOG4105CSV Glutaminase AW03_002410 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase AW03_002420 ENOG4105C26 Dehydrogenase AW03_002430 ENOG4105DJB Major Facilitator Superfamily AW03_002440 ENOG4105EQX glucarate dehydratase AW03_002450 ENOG41073TP transcriptional regulator AW03_002460 ENOG4105CTX dehydratase AW03_002490 ENOG4106UX7 integral membrane protein AW03_002500 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW03_002560 ENOG4105MUA Resistance protein AW03_002570 ENOG4105DGI Alkaline phosphatase AW03_002580 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AW03_002590 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AW03_002600 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) AW03_002610 ENOG4107EPV Aminotransferase class V AW03_002620 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW03_002630 ENOG4105J7D transcriptional regulator AW03_002640 ENOG4107RB3 L-asparaginase AW03_002650 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold AW03_002670 ENOG41060AI SEC-C motif AW03_002690 ENOG4107Y7X LytTR AW03_002700 ENOG4108IUW ABC transporter AW03_002710 ENOG4108SDH ABC, transporter AW03_002720 ENOG4107SET aldo keto reductase AW03_002780 ENOG4105H9W Short-chain dehydrogenase reductase Sdr AW03_002800 ENOG4105DSE periplasmic solute binding protein AW03_002810 ENOG4105DIK (ABC) transporter AW03_002830 ENOG4105DEN Luciferase family AW03_002840 ENOG4108N0M stress protein AW03_002850 ENOG4106FN3 tellurium resistance protein AW03_002860 ENOG4106FN3 tellurium resistance protein AW03_002870 ENOG4107TS3 membrane protein, TerC AW03_002880 ENOG4108TTB tellurium resistance protein AW03_002900 ENOG41079KZ Major Facilitator Superfamily AW03_002910 ENOG4107XZQ multidrug resistance protein AW03_002920 ENOG4108A65 Transcriptional regulator AW03_002930 ENOG4108IJ7 Glycine betaine AW03_002940 ENOG4107SQ8 Glycine betaine AW03_003000 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AW03_003070 ENOG4105EIG urea carboxylase-associated protein 1 AW03_003080 ENOG4107RA1 nh(3)-dependent nad( ) synthetase AW03_003090 ENOG4105I1F Resistance protein AW03_003100 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) AW03_003110 ENOG41089UC methyltransferase, type 11 AW03_003120 ENOG4105C5Q Transcriptional regulator AW03_003130 ENOG4105I82 acetyl xylan esterase AW03_003140 ENOG410756H nucleotidyltransferase AW03_003160 ENOG4105C26 Dehydrogenase AW03_003170 ENOG4105CK7 Sodium proline symporter AW03_003180 ENOG4107YHD transcriptional regulator AW03_003200 ENOG4108PJD permease AW03_003210 ENOG4105U6C Alpha beta hydrolase fold protein AW03_003230 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AW03_003240 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit AW03_003250 ENOG4108IFG nitrite reductase, (NAD(P)H) AW03_003260 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AW03_003300 ENOG4105S7A ErfK ybiS ycfS ynhG family protein AW03_003310 ENOG4105CKI cobalamin synthesis protein AW03_003320 ENOG4105E5Q amino acid AbC transporter AW03_003330 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein AW03_003350 ENOG4105HHM rdd domain containing protein AW03_003370 ENOG4105CS2 ec 3.2.1.21 AW03_003400 ENOG4105C8Q Methyl-accepting chemotaxis AW03_003410 ENOG41080HJ 6-phospho 3-hexuloisomerase AW03_003420 ENOG4108VA3 3-hexulose-6-phosphate synthase AW03_003430 ENOG4105KVH Transcriptional regulator AW03_003440 ENOG4105CEY Amp-dependent synthetase and ligase AW03_003500 ENOG4105SX7 Transporter AW03_003520 ENOG4105W8Z 4'-phosphopantetheinyl transferase AW03_003540 ENOG4105CDA abc transporter atp-binding protein AW03_003550 ENOG4105DRP amino acid AbC transporter AW03_003570 ENOG4106P55 Transcriptional regulator AW03_003580 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase AW03_003590 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) AW03_003600 ENOG41069ZX AW03_003610 ENOG41069ZX AW03_003630 ENOG4105DUX Transporter AW03_003660 ENOG4105E1K spore germination protein AW03_003700 ENOG4107WD8 ABC transporter, permease AW03_003710 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW03_003720 ENOG4105BZU Histidine kinase AW03_003760 ENOG4105CFH Aspartokinase AW03_003770 ENOG4105DHS permease protein AW03_003780 ENOG4105CM4 permease protein AW03_003790 ENOG4108IPW abc transporter atp-binding protein AW03_003820 ENOG4105R8C Transcriptional regulator AW03_003830 ENOG4108DBC nitroreductase AW03_003840 ENOG41067V3 Antibiotic biosynthesis monooxygenase AW03_003850 ENOG4105YVS arsR family transcriptional regulator AW03_003870 ENOG4108JPW Aminotransferase AW03_003880 ENOG4105C26 Dehydrogenase AW03_003900 ENOG4105H9W Short-chain dehydrogenase reductase Sdr AW03_003910 ENOG4105KTB nuclear export factor GLE1 AW03_003920 ENOG4108T5E Copper resistance protein AW03_003930 ENOG4108ZYE Transcriptional regulator AW03_003980 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AW03_004000 ENOG4108ZX0 Signal peptidase I AW03_004050 ENOG4105E7W lamb ycsf family protein AW03_004060 ENOG4105C5A transporter AW03_004070 ENOG4105CFM UPF0317 protein AW03_004080 ENOG4105P4J Allophanate hydrolase, subunit 1 AW03_004100 ENOG4107258 Transcriptional regulator AW03_004110 ENOG4105XJB lipolytic protein G-D-S-L family AW03_004130 ENOG41061CK Antibiotic biosynthesis monooxygenase AW03_004140 ENOG4107RVG penicillin-binding protein AW03_004150 ENOG4107QM2 Aldo Keto reductase AW03_004160 ENOG4105ETD TRANSCRIPTIONal AW03_004180 ENOG4105HMZ Methyltransferase AW03_004190 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AW03_004220 ENOG410606W general stress protein AW03_004240 ENOG4105VCH membrane AW03_004260 ENOG4105C9U ATP-dependent DNA helicase RecQ AW03_004290 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) AW03_004300 ENOG4107R8N Glycosyl transferase, family 2 AW03_004320 ENOG4105C0X amino acid AW03_004360 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) AW03_004380 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) AW03_004390 ENOG4105EU9 AW03_004400 ENOG4105QVS general stress protein AW03_004410 ENOG41082W1 Cupin 2, conserved barrel domain protein AW03_004440 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AW03_004450 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AW03_004460 ENOG4108MRH transcriptional regulatory protein AW03_004470 ENOG4107QJT sodium dicarboxylate symporter AW03_004480 ENOG4106F5Q Membrane AW03_004490 ENOG4105CJ1 ABC, transporter AW03_004520 ENOG4105FDT acyl-CoA dehydrogenase AW03_004560 ENOG4105SZ6 Thioredoxin AW03_004570 ENOG4105CPF Cell wall formation (By similarity) AW03_004580 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) AW03_004590 ENOG4105C1J atp-dependent rna helicase AW03_004600 ENOG410905X membrane-flanked domain protein AW03_004610 ENOG4105CKV Membrane AW03_004630 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) AW03_004640 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein AW03_004650 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AW03_004670 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) AW03_004690 ENOG4107MMM Anti-sigma-factor antagonist AW03_004700 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase AW03_004710 ENOG4107SGM protein serine threonine phosphatase AW03_004720 ENOG4105WN5 stage II sporulation protein AW03_004730 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) AW03_004750 ENOG41064BQ Phosphatase AW03_004770 ENOG4105M5P UPF0310 protein AW03_004780 ENOG4105RV9 Transcriptional regulator AW03_004840 ENOG4105CJA serine threonine protein kinase AW03_004900 ENOG4105CJA serine threonine protein kinase AW03_004910 ENOG4105BZ1 (ABC) transporter AW03_004940 ENOG4105VZ8 Transcriptional regulator AW03_004960 ENOG4105ECK Fatty Acid Desaturase AW03_004970 ENOG4105VEQ Cold shock protein AW03_004980 ENOG4108VJ1 Transcriptional regulator (CarD family AW03_004990 ENOG4108MCI Transcriptional regulator, ARAC family AW03_005000 ENOG4108UZ3 Transporter AW03_005010 ENOG41086D8 Transcriptional regulator AW03_005020 ENOG4107U9B transcriptional regulator AW03_005030 ENOG4105DXI Major Facilitator superfamily AW03_005050 ENOG4105CZ9 Domain of unknown function (DU1801) AW03_005060 ENOG4105GIG AW03_005070 ENOG4105T38 integral membrane protein AW03_005080 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AW03_005090 ENOG4108ZMQ domain protein AW03_005100 ENOG4105MJ9 esterase AW03_005110 ENOG4107Z6X Transcriptional regulator AW03_005130 ENOG4105KVH Transcriptional regulator AW03_005140 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AW03_005160 ENOG4105EQ0 Major Facilitator superfamily AW03_005170 ENOG4108JGH Tetr family transcriptional regulator AW03_005190 ENOG41082YX Transcriptional regulator, arsr family AW03_005200 ENOG4107R5R arsenical pump membrane protein AW03_005210 ENOG4105Z7P Acetyltransferase (GNAT) family AW03_005220 ENOG4108KGH TRANSCRIPTIONal AW03_005230 ENOG4108ZJ4 polysaccharide deacetylase AW03_005250 ENOG4105US7 Histidine kinase AW03_005260 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW03_005270 ENOG4107Y9U Membrane AW03_005290 ENOG4108SQ9 flavin reductase domain protein, FMN-binding AW03_005300 ENOG4108ZHR arsR family transcriptional regulator AW03_005310 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) AW03_005330 ENOG4105ENE Histidine kinase AW03_005340 ENOG4108VB1 regulatoR AW03_005350 ENOG4105EYF MMPL domain protein AW03_005360 ENOG4108WC5 Alpha Beta Hydrolase Fold protein AW03_005370 ENOG4108UQV Membrane AW03_005380 ENOG4108Z5V transcriptional regulator, merr family AW03_005390 ENOG41076HS cation diffusion facilitator family transporter AW03_005400 ENOG4108TVJ Nitroreductase AW03_005410 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase AW03_005420 ENOG4108VGI doxx family AW03_005430 ENOG4105XXY Thioredoxin AW03_005470 ENOG410900G Protein of unknown function (DUF421) AW03_005480 ENOG4108QY0 Membrane AW03_005520 ENOG4105PF9 Transcriptional regulator AW03_005540 ENOG4105WQG acetyltransferase AW03_005560 ENOG4105F27 Major Facilitator AW03_005590 ENOG4105C85 amino acid AW03_005610 ENOG41062A4 Transcriptional regulator AW03_005620 ENOG4105EYF MMPL domain protein AW03_005630 ENOG4108TVJ Nitroreductase AW03_005640 ENOG4105FS7 Transcriptional regulator AW03_005650 ENOG4105C2C drug resistance transporter, Bcr CflA AW03_005670 ENOG4105DRR Transcriptional regulator, GntR family AW03_005680 ENOG4105VRS hydrolase family 18 AW03_005710 ENOG4105G6Z alkaline phosphatase AW03_005720 ENOG4108ZMX Domain of unknown function (DU1801) AW03_005740 ENOG4108YM7 Gcn5-related n-acetyltransferase AW03_005750 ENOG4107TVP HD domain protein AW03_005760 ENOG41090UD (LipO)protein AW03_005770 ENOG4105F27 Major Facilitator AW03_005780 ENOG4105VZJ PTS System AW03_005790 ENOG4105VCP PTS System AW03_005800 ENOG4105CK1 PTS System AW03_005810 ENOG4105CS2 ec 3.2.1.21 AW03_005820 ENOG4108TZY GntR Family Transcriptional Regulator AW03_005830 ENOG4105EVU fructokinase AW03_005840 ENOG4105DG6 mannose-6-phosphate isomerase AW03_005850 ENOG4105D3P Mannan endo-1,4-beta-mannosidase AW03_005870 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) AW03_005880 ENOG4105K8N protein family UPF0079, ATPase AW03_005890 ENOG41072GX Peptidase M22 Glycoprotease AW03_005900 ENOG410801F ribosomal-protein-alanine acetyltransferase AW03_005910 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AW03_005920 ENOG4105C5H ABC transporter AW03_005930 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) AW03_005940 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) AW03_005950 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AW03_005960 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AW03_005980 ENOG4108TYN CAAX amino terminal protease family protein AW03_005990 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) AW03_006000 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) AW03_006020 ENOG4105PGZ NB-ARC domain AW03_006030 ENOG4105CPQ Dehydrogenase AW03_006040 ENOG4105CT4 transporter AW03_006060 ENOG41087YS Phage shock protein A AW03_006070 ENOG4105DQX Zinc finger domain AW03_006080 ENOG4108WV1 Pfam:DUF477 AW03_006100 ENOG4108ZMR Ion transport 2 domain-containing protein AW03_006110 ENOG4107QNK )-transporter AW03_006180 ENOG4107YUH hydrolase AW03_006200 ENOG4107STQ Multicopper oxidase AW03_006220 ENOG4105C85 amino acid AW03_006240 ENOG4105C7R Atpase associated with various cellular activities aaa_3 AW03_006300 ENOG4105C7N Xanthine uracil vitamin C permease AW03_006350 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AW03_006360 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AW03_006370 ENOG4105C83 adenylosuccinate lyase AW03_006380 ENOG4105C8V SAICAR synthetase AW03_006400 ENOG4105VR9 phosphoribosylformylglycinamidine synthase AW03_006410 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii AW03_006430 ENOG4105CXB phosphoribosylaminoimidazole synthetase AW03_006440 ENOG4108V3E phosphoribosylglycinamide formyltransferase AW03_006450 ENOG4105DC1 bifunctional purine biosynthesis protein purh AW03_006460 ENOG4105C12 Phosphoribosylglycinamide synthetase AW03_006480 ENOG4105DVH amino acid AW03_006510 ENOG4108R5T secreted protein AW03_006520 ENOG4105KGF protein, YerC YecD AW03_006530 ENOG4105CBC glutamate synthase AW03_006550 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) AW03_006560 ENOG4105C4R Atp-dependent dna helicase AW03_006570 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AW03_006590 ENOG4105CRN Aminoglycoside phosphotransferase AW03_006600 ENOG4105KT7 mgtC SapB transporter AW03_006610 ENOG4105CK7 Sodium proline symporter AW03_006620 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AW03_006630 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) AW03_006640 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) AW03_006650 ENOG4108IG5 Transcriptional regulator AW03_006670 ENOG4105CBD Diacylglycerol kinase AW03_006680 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AW03_006690 ENOG41069I7 AW03_006810 ENOG4108HFV AW03_006850 ENOG4105CDY transcriptional regulatory protein AW03_006870 ENOG4105M4P Tetr family transcriptional regulator AW03_006880 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein AW03_006890 ENOG4107S9F NmrA family AW03_006920 ENOG4105WEF catalase AW03_006930 ENOG4105M18 -acetyltransferase AW03_006960 ENOG4105C2F Histidine kinase AW03_006970 ENOG4105EQD regulatoR AW03_006980 ENOG410769Z extracellular solute-binding protein family 1 AW03_006990 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component AW03_007000 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component AW03_007010 ENOG4105F5H Glycosyl Hydrolase Family 88 AW03_007020 ENOG41075H3 AraC family transcriptional regulator AW03_007030 ENOG4107TDE lipolytic protein G-D-S-L family AW03_007060 ENOG4105CX8 fg-gap repeat protein AW03_007070 ENOG4105CX8 fg-gap repeat protein AW03_007080 ENOG4107TDE lipolytic protein G-D-S-L family AW03_007100 ENOG4105EKC AW03_007110 ENOG4105E0S extracellular solute-binding protein family 1 AW03_007130 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component AW03_007140 ENOG4105F8D glycoside hydrolase family 4 AW03_007150 ENOG4105H67 Protein of unknown function (DUF421) AW03_007160 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) AW03_007170 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily AW03_007210 ENOG4106I4J membrane AW03_007220 ENOG41061H0 Monooxygenase AW03_007230 ENOG4108R1P AW03_007240 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AW03_007250 ENOG4105E0M Sulfatase AW03_007260 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase AW03_007280 ENOG41090R9 glycosyltransferase AW03_007290 ENOG4107R51 Glycosyl transferase, family 2 AW03_007300 ENOG41090R9 glycosyltransferase AW03_007310 ENOG4105EU0 Major facilitator Superfamily AW03_007330 ENOG4105CUB amino acid AW03_007340 ENOG4105C26 Dehydrogenase AW03_007350 ENOG4105FKZ Methyl-accepting chemotaxis AW03_007360 ENOG4105C5H ABC transporter AW03_007390 ENOG4107SWG transcriptional regulator MERR family AW03_007400 ENOG4105DXB Major Facilitator superfamily AW03_007430 ENOG4105C5H ABC transporter AW03_007440 ENOG4105FDU atp-dependent rna helicase AW03_007460 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AW03_007470 ENOG4105E0A ABC, transporter AW03_007480 ENOG4108U1V ABC transporter, permease AW03_007490 ENOG4105DQ5 transport system permease protein AW03_007500 ENOG4108HUF Transporter AW03_007530 ENOG4108J20 pectate lyase AW03_007540 ENOG4107QPK )-transporter AW03_007560 ENOG4108MRH transcriptional regulatory protein AW03_007610 ENOG410855V Acylphosphatase AW03_007620 ENOG4108RPX mosc domain containing protein AW03_007660 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) AW03_007710 ENOG4105GEU Spore germination protein AW03_007730 ENOG4108Q5U germination protein, ger(x)c family AW03_007750 ENOG4105E1K spore germination protein AW03_007760 ENOG4105C5Y PTS System AW03_007770 ENOG4105CG3 alpha amylase, catalytic region AW03_007780 ENOG4107414 GntR family transcriptional regulator AW03_007790 ENOG4108RCM Nitroreductase AW03_007800 ENOG4105CGH 5'-nucleotidase AW03_007810 ENOG4107RKG DJ-1/PfpI family AW03_007840 ENOG4105KJF protein tyrosine phosphatase AW03_007860 ENOG4107U9T Pfam:Ribonuclease_BN AW03_007880 ENOG4108ISG Major Facilitator AW03_007890 ENOG4105UPD Calcium Proton AW03_007910 ENOG4105D8X mechanosensitive ion channel AW03_007950 ENOG4106KE4 Dehydrogenase AW03_007960 ENOG4105D7N magnesium and cobalt transport protein CorA AW03_007980 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AW03_008030 ENOG4107RUY (E1 component), alpha subunit AW03_008050 ENOG4107QKR Dehydrogenase AW03_008070 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AW03_008080 ENOG41069DP small acid-soluble spore protein AW03_008090 ENOG4105KK4 UPF0060 membrane protein AW03_008140 ENOG4105F8D glycoside hydrolase family 4 AW03_008150 ENOG4108Q3X Transcriptional regulator AW03_008160 ENOG4105CI1 PTS System AW03_008170 ENOG4105BZ1 (ABC) transporter AW03_008180 ENOG4105BZ1 (ABC) transporter AW03_008200 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase AW03_008210 ENOG4105BZU Histidine kinase AW03_008220 ENOG4105WH1 Two component transcriptional regulator luxr family AW03_008230 ENOG4105CJ1 ABC, transporter AW03_008240 ENOG41090VJ ABC-2 type transporter AW03_008250 ENOG4108KYE ABC-2 type transporter AW03_008270 ENOG4105U3E Transcriptional regulator AW03_008280 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold AW03_008290 ENOG4105EJ2 Transcriptional regulator AW03_008320 ENOG4105CJ1 ABC, transporter AW03_008330 ENOG4105H93 Acyltransferase family AW03_008340 ENOG4105YA8 Transcriptional regulator AW03_008350 ENOG4107Y80 Major Facilitator superfamily AW03_008360 ENOG4108YYS metal-dependent hydrolase (By similarity) AW03_008370 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW03_008380 ENOG410834F Transcriptional regulator AW03_008400 ENOG4108MES Periplasmic binding protein AW03_008410 ENOG4105DQ5 transport system permease protein AW03_008420 ENOG4108IHU transport system permease protein AW03_008430 ENOG4105JAB phenazine biosynthesis protein, phzf family AW03_008440 ENOG4107Y03 Nitroreductase AW03_008470 ENOG4105ECP epimerase AW03_008510 ENOG4105F27 Major Facilitator AW03_008550 ENOG4106AKJ AW03_008560 ENOG4105D74 hydrolase AW03_008570 ENOG4105CKK Glycosyl transferase, family 2 AW03_008580 ENOG4105EJV Membrane AW03_008590 ENOG41067AE Membrane-bound metal-dependent hydrolase AW03_008600 ENOG4105CEN a g-specific adenine glycosylase AW03_008610 ENOG4106BXE AW03_008620 ENOG4105CAN Short-chain dehydrogenase reductase Sdr AW03_008650 ENOG4105EVI UPF0374 protein AW03_008660 ENOG4105BZ1 (ABC) transporter AW03_008670 ENOG4107NBY Membrane AW03_008690 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AW03_008700 ENOG4105G5W regulator Fur family AW03_008730 ENOG4108N23 SpoOM-related protein AW03_008750 ENOG4105EC3 peptidase S51, dipeptidase E AW03_008770 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) AW03_008800 ENOG4105E2Y ABC, transporter AW03_008810 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein AW03_008820 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AW03_008830 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) AW03_008850 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) AW03_008860 ENOG4107D63 AW03_008870 ENOG4105VZ8 Transcriptional regulator AW03_008890 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AW03_008910 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AW03_008950 ENOG4105CYN Serine protein kinase AW03_008960 ENOG4106AKX UPF0229 protein AW03_008970 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes AW03_008980 ENOG4105CW7 secretion protein, HlyD family AW03_008990 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW03_009000 ENOG4105CS1 NAD(P)H quinone oxidoreductase AW03_009030 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family AW03_009040 ENOG4105CZV ABC transporter AW03_009050 ENOG4105CJ1 ABC, transporter AW03_009060 ENOG4108TU7 Inherit from COG: (ABC) transporter AW03_009070 ENOG4105VEQ Cold shock protein AW03_009090 ENOG4105BZU Histidine kinase AW03_009170 ENOG4108YBP pseudouridine synthase AW03_009190 ENOG41080XP Cbs domain AW03_009200 ENOG4107YBY Hydrolase AW03_009210 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AW03_009220 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AW03_009230 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AW03_009250 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) AW03_009260 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AW03_009280 ENOG4105BZU Histidine kinase AW03_009290 ENOG4105WH1 Two component transcriptional regulator luxr family AW03_009370 ENOG4105ED1 spovr family AW03_009380 ENOG4105G6Z alkaline phosphatase AW03_009410 ENOG4105BZN citrate synthase AW03_009420 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AW03_009430 ENOG4105CUB amino acid AW03_009440 ENOG4105C8J )-transporter AW03_009460 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AW03_009490 ENOG4105J37 AW03_009500 ENOG4108AEY RNA polymerase sigma factor AW03_009510 ENOG4108FN7 Aldo keto reductase AW03_009520 ENOG4105F6E Acyl-transferase AW03_009530 ENOG4105C37 (CBS) domain AW03_009550 ENOG4105CHM Aminotransferase AW03_009560 ENOG4105C37 (CBS) domain AW03_009580 ENOG4105WMR Protein CrcB homolog AW03_009590 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AW03_009610 ENOG4105D64 Mechanosensitive ion channel AW03_009620 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AW03_009630 ENOG4107VMI polysaccharide deacetylase AW03_009640 ENOG4105F0I Aminotransferase AW03_009680 ENOG4105BZ1 (ABC) transporter AW03_009690 ENOG4105BZ1 (ABC) transporter AW03_009740 ENOG410839P AW03_009760 ENOG4106MP8 UPF0754 membrane protein AW03_009770 ENOG4105WZB UPF0342 protein AW03_009780 ENOG4105F1N DNA alkylation repair AW03_009800 ENOG4105D4P Coproporphyrinogen iii oxidase AW03_009810 ENOG4107S91 Sodium hydrogen exchanger AW03_009820 ENOG4105NCW Trka-c domain protein AW03_009840 ENOG4105CGU Enoyl-CoA hydratase AW03_009860 ENOG4108IUX (ABC) transporter AW03_009870 ENOG4105RHA ABC transporter, permease AW03_009880 ENOG4107VRP DNA repair exonuclease AW03_009890 ENOG4106D4I domain protein AW03_009900 ENOG4105EQI Metal Dependent Phosphohydrolase AW03_009920 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) AW03_009980 ENOG4105NBU tryptophan transport protein AW03_009990 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) AW03_010000 ENOG4105K59 histidine triad (HIT) protein AW03_010070 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation AW03_010080 ENOG4105BZ4 penicillin-binding protein AW03_010090 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) AW03_010100 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) AW03_010110 ENOG4105C1Q protoporphyrinogen oxidase AW03_010130 ENOG4105ECB domain protein AW03_010150 ENOG41090T1 Membrane AW03_010160 ENOG4105DER m42 family AW03_010190 ENOG4108RQ5 Beta-lactamase domain-containing protein AW03_010200 ENOG4105DF9 Lipoate-protein, ligase AW03_010230 ENOG4105CEY Amp-dependent synthetase and ligase AW03_010250 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 AW03_010260 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AW03_010270 ENOG4105KD7 acetyltransferase AW03_010290 ENOG4108HUF Transporter AW03_010300 ENOG4107TB6 phosphoglycerate mutase AW03_010330 ENOG4107F3J Amp-dependent synthetase and ligase AW03_010340 ENOG4107ZYJ bioY protein AW03_010350 ENOG4106YBV Methyl-accepting chemotaxis AW03_010390 ENOG4105XVF Competence transcription factor AW03_010400 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AW03_010410 ENOG4105X3H Excalibur domain protein AW03_010420 ENOG4105E1V na solute symporter AW03_010430 ENOG4106CAD Protein of unknown function (DUF3311) AW03_010440 ENOG41060YP AW03_010470 ENOG4107SCK Monooxygenase AW03_010480 ENOG4108INS Transcriptional regulator AW03_010510 ENOG4105TRI Hydrolase AW03_010540 ENOG4108KK1 membrane protein AbrB duplication AW03_010550 ENOG4106K7D Major facilitator family transporter AW03_010560 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AW03_010590 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation AW03_010610 ENOG4105EYH Exonuclease AW03_010710 ENOG4105ERH Fumarylacetoacetate hydrolase AW03_010730 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AW03_010750 ENOG4105CAQ asparagine synthetase AW03_010770 ENOG4105UQX Mate efflux family protein AW03_010780 ENOG4106HBX Transcriptional Regulator AraC Family AW03_010790 ENOG4105ETE Transcriptional regulator (LacI family AW03_010800 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) AW03_010810 ENOG4105SF0 DinB family AW03_010820 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AW03_010830 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AW03_010840 ENOG4105MYW Pentapeptide repeat protein AW03_010850 ENOG4107S9D Alpha beta hydrolase AW03_010860 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AW03_010870 ENOG4107RIQ Sulfate adenylate transferase AW03_010880 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) AW03_010890 ENOG4108N5B 2-phosphosulfolactate phosphatase AW03_010900 ENOG41061P3 phosphosulfolactate synthase AW03_010920 ENOG4105DIA mandelate racemase muconate lactonizing AW03_010930 ENOG4107RCC Major Facilitator Superfamily AW03_010940 ENOG4108SZE gCN5-related N-acetyltransferase AW03_010950 ENOG4105MA6 gCN5-related N-acetyltransferase AW03_010970 ENOG4108VPT UPF0234 protein AW03_010980 ENOG4105QNR S1 RNA binding domain protein AW03_011020 ENOG4105K7K Transcriptional regulator AW03_011040 ENOG410751J AW03_011050 ENOG4105D4Y metalloprotease AW03_011060 ENOG4105EPR degv family AW03_011070 ENOG4107AYK membrAne AW03_011090 ENOG41073B9 AW03_011120 ENOG4108KP7 hydrolase AW03_011130 ENOG4108MXZ Esterase AW03_011140 ENOG4105VG1 fes assembly suf system protein AW03_011160 ENOG4105IQ5 FAD linked oxidase domain protein AW03_011180 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AW03_011210 ENOG4105C8Y Acetylornithine aminotransferase AW03_011220 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AW03_011240 ENOG4105DBV ornithine carbamoyltransferase AW03_011290 ENOG4107RMD Basic membrane lipoprotein AW03_011320 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) AW03_011330 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AW03_011350 ENOG4105C3U ABC transporter AW03_011360 ENOG4108JQ7 (ABC) transporter AW03_011390 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AW03_011410 ENOG4105C31 Tryptophanyl-tRNA synthetase AW03_011420 ENOG4108J59 Extracellular solute-binding protein, family 5 AW03_011430 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AW03_011450 ENOG4108JQ7 (ABC) transporter AW03_011480 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) AW03_011490 ENOG4108ZCF integral membrane protein AW03_011500 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis AW03_011520 ENOG4105DPN Oligoendopeptidase f AW03_011540 ENOG4105T58 Dithiol-disulfide isomerase AW03_011550 ENOG4108Z18 K06886 hemoglobin AW03_011560 ENOG4105E4C Lytic transglycosylase catalytic AW03_011570 ENOG4105MIX Adenylate cyclase AW03_011600 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AW03_011610 ENOG4105EMS pseudouridine synthase AW03_011640 ENOG4105ETU transcriptional activator (TenA AW03_011650 ENOG4108VEU Thiamine monophosphate synthase AW03_011680 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) AW03_011690 ENOG4105D06 uba thif-type nad fad binding protein AW03_011700 ENOG4105DWF phosphomethylpyrimidine kinase AW03_011710 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH AW03_011720 ENOG4107A88 AW03_011820 ENOG4105ENA helicase AW03_011850 ENOG4108ZMI UPF0477 protein AW03_011870 ENOG4105C28 cystathionine AW03_011880 ENOG4105C28 cystathionine AW03_011890 ENOG4105D9U N-acetyltransferase AW03_011900 ENOG4105JHY Membrane AW03_012020 ENOG4105DM4 PTS System AW03_012030 ENOG4105DG6 mannose-6-phosphate isomerase AW03_012040 ENOG4105G7B Protein of unknown function (DUF2992) AW03_012050 ENOG4105VMI -acetyltransferase AW03_012070 ENOG4108Z66 YbaK ebsC protein AW03_012100 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AW03_012120 ENOG4108ZJ4 polysaccharide deacetylase AW03_012130 ENOG4107CUJ Protein of unknown function (DUF2690) AW03_012180 ENOG4108IEG Formate dehydrogenase Alpha subunit AW03_012220 ENOG4106A3M Cytochrome p-450 AW03_012230 ENOG41087PP glycosyltransferase MGT family AW03_012250 ENOG4105EXQ uroporphyrinogen iii synthase hem4 AW03_012260 ENOG4105C4B ABC transporter, permease AW03_012270 ENOG4108IXI (ABC) transporter AW03_012290 ENOG4105Q95 Cupin 2, conserved barrel domain protein AW03_012320 ENOG4105D2H Uronic isomerase AW03_012330 ENOG4105CT4 transporter AW03_012340 ENOG4105DG4 malate L-lactate dehydrogenase AW03_012350 ENOG4105CPQ Dehydrogenase AW03_012360 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) AW03_012370 ENOG4105DMW Dehydrogenase reductase AW03_012380 ENOG4108I5G Major Facilitator superfamily AW03_012390 ENOG4107KJX Transcriptional regulator AW03_012400 ENOG4107QZW Altronate oxidoreductase AW03_012410 ENOG4105CTX dehydratase AW03_012420 ENOG4107TSN permease AW03_012440 ENOG4105JD4 ATPase yjob AW03_012470 ENOG41068K0 YCII-related domain AW03_012480 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AW03_012490 ENOG4105KWG Pfam:DUF1696 AW03_012500 ENOG4105K7W phage-related replication protein AW03_012510 ENOG4105WEF catalase AW03_012520 ENOG410635T phage-like element pbsx protein AW03_012610 ENOG4108TFU terminase (Small subunit) AW03_012620 ENOG4105IG6 Phage terminase, large subunit AW03_012630 ENOG4108MDF Phage Portal Protein AW03_012680 ENOG41060SN AW03_012700 ENOG4105PQS phage protein AW03_012710 ENOG4105FR7 XkdM protein, phage-like element PBSX AW03_012720 ENOG4105MTC XkdN-like protein AW03_012730 ENOG4108FKH Transglycosylase SLT domain AW03_012740 ENOG4108WZM domain protein AW03_012750 ENOG4105X7F AW03_012770 ENOG4105MFU Protein of unknown function (DUF2634) AW03_012780 ENOG41066EA baseplate J family protein AW03_012790 ENOG410906S phage-like element pbsx protein xkdt AW03_012820 ENOG41068G1 AW03_012880 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AW03_012920 ENOG4105CJ3 phosphate transporter AW03_012930 ENOG4107GRR phosphate transport regulator AW03_012940 ENOG4107R7I amino acid AW03_012960 ENOG4105EDW glycosyl transferase, family 39 AW03_012970 ENOG4105CKK Glycosyl transferase, family 2 AW03_012990 ENOG4105C0H protease AW03_013010 ENOG4108ME1 Peptidase M55 D-aminopeptidase AW03_013020 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AW03_013030 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AW03_013040 ENOG4105C3U ABC transporter AW03_013070 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AW03_013080 ENOG4105DTQ mandelate racemase muconate lactonizing AW03_013090 ENOG4107SN7 NLP P60 protein AW03_013100 ENOG4108JQ7 (ABC) transporter AW03_013110 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) AW03_013120 ENOG4107TUM Amidinotransferase AW03_013130 ENOG4108S4H thioesterase Superfamily protein AW03_013140 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AW03_013180 ENOG4108428 Inherit from COG: -acetyltransferase AW03_013200 ENOG41080TC multidrug resistance protein AW03_013210 ENOG4105CIY formyltetrahydrofolate deformylase AW03_013220 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AW03_013250 ENOG4105K56 Transcriptional regulator AW03_013260 ENOG4108ZHJ Organic hydroperoxide resistance protein AW03_013270 ENOG4107Y2X deaminase AW03_013290 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AW03_013300 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AW03_013320 ENOG4108W7F transporter, permease AW03_013330 ENOG4108JJB ABC transporter AW03_013340 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein AW03_013350 ENOG4108X43 YKOF domain protein AW03_013360 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW03_013370 ENOG41062D9 Histidine kinase AW03_013390 ENOG4106849 propeptide, pepSY amd peptidase M4 AW03_013420 ENOG4105CJW magnesium transporter AW03_013430 ENOG4105V75 Transcriptional regulator AW03_013520 ENOG4105DQE DNA ligase AW03_013530 ENOG4105FDF Could be involved in DNA repair (By similarity) AW03_013540 ENOG4105BZU Histidine kinase AW03_013550 ENOG4107T5V SNARE associated Golgi AW03_013570 ENOG4107TS3 membrane protein, TerC AW03_013580 ENOG4108WZW RNA polymerase sigma AW03_013600 ENOG410681C small acid-soluble spore protein AW03_013620 ENOG4105D0M Protease HtpX homolog AW03_013660 ENOG4108TGC Acyltransferase AW03_013670 ENOG4105BZU Histidine kinase AW03_013680 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AW03_013700 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) AW03_013710 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) AW03_013720 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AW03_013740 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit AW03_013750 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) AW03_013760 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) AW03_013770 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) AW03_013810 ENOG4105BZU Histidine kinase AW03_013820 ENOG41090MY MarR family Transcriptional regulator AW03_013830 ENOG4105ER2 Ompa motb domain protein AW03_013840 ENOG4105E14 MotA TolQ exbB proton channel AW03_013860 ENOG4108K88 Membrane AW03_013870 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) AW03_013880 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase AW03_013890 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AW03_013900 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) AW03_013910 ENOG4105FEA Spore maturation protein AW03_013970 ENOG4105F0V Cell wall hydrolase AW03_014000 ENOG4105C59 p-type ATPase AW03_014010 ENOG4105DC7 peptidase M24 AW03_014030 ENOG4105CID antiterminator AW03_014050 ENOG4105KRI phosphocarrier protein (HPr AW03_014060 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AW03_014080 ENOG4105F6S Spore photoproduct lyase AW03_014100 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer AW03_014110 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AW03_014120 ENOG4105K4I Scp-like extracellular AW03_014140 ENOG4105BZU Histidine kinase AW03_014150 ENOG4105CHM Aminotransferase AW03_014170 ENOG4107R88 Chemotaxis protein (CheV) AW03_014180 ENOG4105UIN AW03_014200 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein AW03_014220 ENOG4105K6S Short-chain dehydrogenase reductase Sdr AW03_014230 ENOG4105EPM Diguanylate phosphodiesterase AW03_014250 ENOG4107IN1 Protein of unknown function (DUF1797) AW03_014260 ENOG4108XRC Protein of unknown function (DUF458) AW03_014320 ENOG4105NQC Flavodoxin AW03_014340 ENOG4105CH2 amidohydrolase AW03_014360 ENOG4105D8X mechanosensitive ion channel AW03_014370 ENOG4105D3R alkyl hydroperoxide reductase AW03_014380 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AW03_014410 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) AW03_014420 ENOG4105D06 uba thif-type nad fad binding protein AW03_014430 ENOG4105CVM Molybdenum cofactor synthesis domain protein AW03_014440 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein AW03_014450 ENOG4108ZAF Molybdopterin AW03_014460 ENOG41067WU Molybdopterin converting factor (Subunit 1) AW03_014470 ENOG4105BZ1 (ABC) transporter AW03_014480 ENOG4105BZ1 (ABC) transporter AW03_014500 ENOG4107X8C Efflux transporter RND family MFP subunit AW03_014510 ENOG4105C19 ABC transporter AW03_014520 ENOG4107RBB ABC transporter, permease AW03_014530 ENOG4105E98 transcriptional regulator DeoR family AW03_014540 ENOG4105DE4 1-phosphofructokinase AW03_014550 ENOG4105DM4 PTS System AW03_014560 ENOG4105C3F Signal peptidase i AW03_014580 ENOG4105C5H ABC transporter AW03_014600 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AW03_014620 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AW03_014680 ENOG4105BZU Histidine kinase AW03_014700 ENOG4107ZYR domain protein AW03_014720 ENOG4105CN5 Metallo-Beta-Lactamase AW03_014740 ENOG4108X4Q Hydrolase AW03_014750 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AW03_014790 ENOG4105CPP Dehydrogenase, E1 component AW03_014800 ENOG4105C7S Dehydrogenase AW03_014810 ENOG4107QN2 dihydrolipoyl dehydrogenase AW03_014840 ENOG4105CXN decarboxylase AW03_014850 ENOG4105WBI UPF0223 protein AW03_014880 ENOG4105ECY inositol monophosphatase AW03_014900 ENOG4105JQZ Methyltransferase AW03_014980 ENOG4105CI3 gtp-binding protein typa AW03_014990 ENOG4105QA2 AW03_015020 ENOG4108IAB Phoh family AW03_015040 ENOG4105CSV Glutaminase AW03_015050 ENOG4105ZPI UPF0358 protein AW03_015060 ENOG4105CNI cell division protein FtsW AW03_015070 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) AW03_015090 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) AW03_015110 ENOG4105BZ9 Cytochrome C oxidase, subunit I AW03_015120 ENOG4105CCU oxidase (Subunit III) AW03_015130 ENOG41064X9 cytochrome C oxidase subunit IV AW03_015160 ENOG41080XQ Signal transduction protein with cbs domains AW03_015170 ENOG4106UY4 Inherit from COG: Scp-like extracellular AW03_015210 ENOG4105WUC UPF0298 protein AW03_015220 ENOG4106H78 methyltransferase AW03_015230 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) AW03_015240 ENOG4105H20 Sporulation integral membrane protein YlbJ AW03_015250 ENOG4105D78 K07001 NTE family protein AW03_015260 ENOG41063PX domain protein AW03_015280 ENOG4105CDE UPF0348 protein AW03_015300 ENOG4105KNH Nucleic acid-binding protein AW03_015310 ENOG41067VY 50S ribosomal protein L32 AW03_015360 ENOG4108V6E Cell division protein mraZ AW03_015370 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) AW03_015390 ENOG4105CJN penicillin-binding protein AW03_015400 ENOG4105CJN penicillin-binding protein AW03_015410 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AW03_015420 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) AW03_015430 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AW03_015440 ENOG4105CNI cell division protein FtsW AW03_015450 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) AW03_015460 ENOG4105D4A Cell wall formation (By similarity) AW03_015470 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) AW03_015480 ENOG4108R2U division initiation protein AW03_015500 ENOG4105K67 small basic protein AW03_015510 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AW03_015520 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AW03_015540 ENOG4105FFI sigma-e processing peptidase spoiiga AW03_015550 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW03_015570 ENOG4105DKW ABC transporter AW03_015590 ENOG4105WR5 sporulation protein, YlmC YmxH family AW03_015600 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AW03_015610 ENOG4105DFA alanine racemase domain protein AW03_015620 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) AW03_015630 ENOG41067XK integral membrane protein AW03_015640 ENOG4105DBK s4 domain protein AW03_015660 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AW03_015680 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) AW03_015690 ENOG4105C34 Pseudouridine synthase AW03_015700 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) AW03_015720 ENOG4105CXT aspartate transcarbamylase AW03_015740 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AW03_015750 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AW03_015760 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) AW03_015770 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) AW03_015780 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) AW03_015790 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) AW03_015810 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) AW03_015830 ENOG4107S4M Sulfate adenylate transferase AW03_015840 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) AW03_015850 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) AW03_015860 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein AW03_015870 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein AW03_015880 ENOG4105F23 Fibronectin-binding protein AW03_015900 ENOG4105DSJ YicC domain protein AW03_015910 ENOG4105KC4 UPF0296 protein AW03_015920 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AW03_015940 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AW03_015950 ENOG4105C25 Primosomal protein n' AW03_015960 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) AW03_015970 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) AW03_015980 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B AW03_015990 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs AW03_016000 ENOG4108ZF3 Phosphatase AW03_016010 ENOG4105D9P serine threonine protein kinase AW03_016020 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) AW03_016030 ENOG4105DJV ribulose-phosphate 3-epimerase AW03_016040 ENOG4105FJ0 thiamine AW03_016050 ENOG4105VB9 50S ribosomal protein l28 AW03_016060 ENOG4108ZAA Alkaline-shock protein AW03_016070 ENOG4105DP4 dak2 domain fusion protein ylov AW03_016090 ENOG4105EJQ L-serine dehydratase AW03_016100 ENOG4105CB5 ATP-dependent DNA helicase recG AW03_016110 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) AW03_016140 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AW03_016150 ENOG4105CHR reductase AW03_016160 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AW03_016170 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) AW03_016180 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) AW03_016190 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AW03_016210 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) AW03_016230 ENOG4105K5M 30s ribosomal protein S16 AW03_016240 ENOG4108BW8 UPF0109 protein AW03_016260 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) AW03_016270 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) AW03_016280 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) AW03_016290 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) AW03_016300 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AW03_016320 ENOG4105VM1 flagellar AW03_016330 ENOG4105CMV Succinyl-CoA synthetase subunit beta AW03_016340 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AW03_016350 ENOG4105C79 DNA protecting protein DprA AW03_016360 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AW03_016370 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) AW03_016380 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AW03_016390 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) AW03_016400 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) AW03_016420 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AW03_016430 ENOG4108ZC9 flagellar basal-body rod protein flgc AW03_016440 ENOG4105VQ0 flagellar hook-basal body complex protein fliE AW03_016450 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AW03_016460 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AW03_016490 ENOG4106YF4 Flagellar biosynthesis chaperone AW03_016510 ENOG410696Y Flagellar hook-length control protein AW03_016520 ENOG410822I Flagellar hook capping protein AW03_016530 ENOG4108JQA flagellar AW03_016550 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AW03_016560 ENOG4105DD5 Flagellar motor switch protein AW03_016570 ENOG4107YTP response regulator receiver protein AW03_016590 ENOG4105CN7 Flagellar biosynthetic protein FliP AW03_016600 ENOG4105VS8 Flagellar biosynthetic protein fliq AW03_016610 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AW03_016620 ENOG4105D00 flagellar biosynthetic protein flhB AW03_016630 ENOG4105D7B Flagellar biosynthesis protein flha AW03_016640 ENOG4105FZW flagellar biosynthesis regulator FlhF AW03_016660 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AW03_016670 ENOG4105CBS Chea signal transduction histidine kinase AW03_016680 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis AW03_016710 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW03_016730 ENOG4105CE9 30S ribosomal protein S2 AW03_016740 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) AW03_016760 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) AW03_016770 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AW03_016780 ENOG4105KNE Phosphatidate cytidylyltransferase AW03_016810 ENOG4105DZP Membrane-associated zinc metalloprotease AW03_016820 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) AW03_016830 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) AW03_016840 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) AW03_016850 ENOG4105CHV Transcription elongation factor NusA AW03_016860 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination AW03_016870 ENOG4105VHM ribosomal protein AW03_016880 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) AW03_016890 ENOG4105W7A Protein of unknown function (DUF503) AW03_016900 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) AW03_016910 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AW03_016920 ENOG4105DTN riboflavin biosynthesis protein ribF AW03_016930 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) AW03_016940 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) AW03_016960 ENOG4105C1V Peptidase, M16 AW03_016980 ENOG4105E35 Dipicolinate synthase subunit A AW03_016990 ENOG4108S0H Dipicolinic acid synthetase, b subunit AW03_017000 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AW03_017020 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AW03_017040 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit AW03_017060 ENOG4105CNU cell division protein FtsK AW03_017070 ENOG4105FDP GntR family transcriptional regulator AW03_017110 ENOG4108RKS Short-chain dehydrogenase reductase Sdr AW03_017120 ENOG4105XZV Protein of unknown function (DUF3243) AW03_017150 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AW03_017160 ENOG4105CEV competence damage-inducible protein AW03_017180 ENOG4108A04 Beta-lactamase AW03_017190 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) AW03_017200 ENOG4105D48 metallophosphoesterase AW03_017210 ENOG4105MCT stage V sporulation protein S AW03_017230 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AW03_017240 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AW03_017270 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) AW03_017280 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) AW03_017300 ENOG4105IIP Membrane AW03_017310 ENOG4105W1N transcriptional regulator AW03_017320 ENOG4108151 Beta-lactamase domain protein AW03_017330 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AW03_017350 ENOG4107QKG PfaD family AW03_017360 ENOG41062T2 Acyl carrier protein AW03_017370 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase AW03_017380 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase AW03_017390 ENOG4108MGH Enoyl-CoA hydratase AW03_017400 ENOG4108KQ6 Enoyl-CoA hydratase AW03_017410 ENOG4105C0W non-ribosomal peptide synthetase AW03_017420 ENOG4107SQU synthase AW03_017440 ENOG4105C0W non-ribosomal peptide synthetase AW03_017460 ENOG4106A3M Cytochrome p-450 AW03_017490 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AW03_017510 ENOG4105K7W phage-related replication protein AW03_017520 ENOG4108X3M OsmC Ohr family protein AW03_017530 ENOG410814C multidrug resistance protein AW03_017570 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) AW03_017580 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AW03_017610 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AW03_017620 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AW03_017630 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AW03_017640 ENOG4105U6W MutT NUDIX family protein AW03_017650 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AW03_017660 ENOG4106F1P AAA ATPase, central domain protein AW03_017670 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AW03_017680 ENOG4105CXI aluminum resistance protein AW03_017690 ENOG4105KV4 Transcriptional regulator AW03_017700 ENOG4105C5F glutamine synthetase AW03_017740 ENOG4106BHF AW03_017760 ENOG41079P0 AW03_017810 ENOG4107AUC AW03_017850 ENOG4107NTZ AW03_017890 ENOG4105CT4 transporter AW03_017900 ENOG4105DSG hydrolase family 43 AW03_017910 ENOG4105E2R ROK family AW03_017930 ENOG4105C93 Xylose Isomerase AW03_017940 ENOG4105CMG Carbohydrate kinase AW03_017950 ENOG4107Y9E nuclease AW03_017960 ENOG4105C54 Major Facilitator superfamily AW03_017970 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AW03_017990 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) AW03_018020 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AW03_018130 ENOG4108Q8B Spore germination protein AW03_018140 ENOG4108NHD germination protein AW03_018170 ENOG4105FVX AW03_018190 ENOG4105K7W phage-related replication protein AW03_018210 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) AW03_018220 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AW03_018240 ENOG4108SVB resolvase AW03_018250 ENOG4105VPS UPF0291 protein AW03_018260 ENOG4105CV1 Transketolase (EC 2.2.1.1) AW03_018290 ENOG4107QIV Cytochrome c biogenesis protein AW03_018350 ENOG4107DZX Small, acid-soluble spore protein P AW03_018370 ENOG4108I0Z Aconitate hydratase AW03_018380 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AW03_018410 ENOG41067CD Small, acid-soluble spore protein Tlp AW03_018430 ENOG4105MI2 AW03_018440 ENOG4105W8X HesB YadR YfhF-family protein AW03_018450 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) AW03_018460 ENOG4105K4P CoA-binding domain protein AW03_018470 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AW03_018510 ENOG4107QWR cellulase (EC 3.2.1.4) AW03_018540 ENOG4108MYR Secreted protein AW03_018550 ENOG4107SYN Glycosyl hydrolases family 43 AW03_018570 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AW03_018580 ENOG4107T5V SNARE associated Golgi AW03_018600 ENOG4107QX3 carboxylase AW03_018610 ENOG4105E39 Enoyl-CoA hydratase AW03_018620 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase AW03_018630 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit AW03_018640 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AW03_018650 ENOG4105CEY Amp-dependent synthetase and ligase AW03_018660 ENOG4105C1G acyl-Coa dehydrogenase AW03_018680 ENOG4105F32 YngK protein AW03_018690 ENOG4106U2H Protein of unknown function (DUF1360) AW03_018720 ENOG4105CEY Amp-dependent synthetase and ligase AW03_018730 ENOG4105C0W non-ribosomal peptide synthetase AW03_018750 ENOG4105C0W non-ribosomal peptide synthetase AW03_018760 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family AW03_018770 ENOG4108N2V aldose 1-epimerase AW03_018780 ENOG4107QJQ Mate efflux family protein AW03_018820 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AW03_018830 ENOG4105SKE transcriptional Regulator LysR family AW03_018840 ENOG4105CB2 alcohol dehydrogenase AW03_018850 ENOG4105BZ8 glutamate synthase AW03_018860 ENOG4105CBC glutamate synthase AW03_018870 ENOG4105C5Q Transcriptional regulator AW03_018880 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) AW03_018890 ENOG4105II7 pyrroline-5-carboxylate reductase AW03_018930 ENOG4108UB7 AW03_018940 ENOG41068WN AW03_018950 ENOG4105IE8 Alpha-ketoglutarate permease AW03_018960 ENOG4107U6E carbohydrate kinase FGGY AW03_018970 ENOG4108M3J Dehydrogenase AW03_018980 ENOG4108J2R molybdopterin oxidoreductase AW03_019020 ENOG4105EC8 Methyl-accepting chemotaxis AW03_019040 ENOG4108YQE rare lipoprotein a AW03_019050 ENOG4105XPP Protein of unknown function (DUF1275) AW03_019060 ENOG4108NR7 pectate lyase AW03_019070 ENOG4108RAV Conserved protein AW03_019100 ENOG4105F0F Oxalate decarboxylase AW03_019130 ENOG41073R8 VanW family AW03_019150 ENOG4105VMP Transcriptional regulator AW03_019160 ENOG4105NX3 Membrane AW03_019180 ENOG4108Q5Y Membrane AW03_019200 ENOG4108V4B ThiJ pfpI AW03_019210 ENOG4108J4B Beta-lactamase AW03_019240 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AW03_019250 ENOG4107T94 Endo-14-beta-xylanase AW03_019290 ENOG4106ANW SMI1_KNR4 AW03_019300 ENOG4106BHF AW03_019340 ENOG4108Z7R Chaperone CsaA AW03_019350 ENOG4105FTV AraC Family Transcriptional Regulator AW03_019360 ENOG4108HJF gCN5-related N-acetyltransferase AW03_019380 ENOG4108W8B Beta-lactamase domain protein AW03_019400 ENOG4105D29 Helix-turn-helix type 11 domain protein AW03_019420 ENOG4105KTU Transcriptional regulator, arsr family AW03_019440 ENOG4108SJC Membrane AW03_019480 ENOG4105ECK Fatty Acid Desaturase AW03_019490 ENOG4108ZGX Histidine kinase AW03_019500 ENOG4108S01 response regulator AW03_019510 ENOG41069ER domain protein AW03_019520 ENOG4105C9U ATP-dependent DNA helicase RecQ AW03_019540 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AW03_019550 ENOG4105SCY DNAK suppressor AW03_019630 ENOG4105C26 Dehydrogenase AW03_019640 ENOG4105EWU Squalene--hopene cyclase AW03_019650 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AW03_019660 ENOG4105C8J )-transporter AW03_019670 ENOG4105C09 Bile acid AW03_019680 ENOG4105C7S Dehydrogenase AW03_019700 ENOG4107T89 von Willebrand factor, type A AW03_019710 ENOG4105GMT ATPase associated with various cellular activities aaa_5 AW03_019740 ENOG4105K4H Nlp p60 protein AW03_019750 ENOG41087PP glycosyltransferase MGT family AW03_019780 ENOG4107QMU Mate efflux family protein AW03_019790 ENOG4106SCS STAS domain AW03_019830 ENOG4105FR1 rard protein AW03_019860 ENOG4105C6Z Gluconate AW03_019870 ENOG41090U3 tautomerase AW03_019900 ENOG4105FBA Phospholipase Carboxylesterase AW03_019930 ENOG4105E1V na solute symporter AW03_019970 ENOG4108VXD carboxy-peptidase AW03_019980 ENOG4105D3A purine nucleoside phosphorylase DeoD-type AW03_020000 ENOG4106Z5R AW03_020010 ENOG410841Q phosphoesterase PA-phosphatase related protein AW03_020070 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AW03_020080 ENOG4108TSC N-acetyltransferase AW03_020090 ENOG4107S4Y M20 DapE family protein YgeY AW03_020120 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AW03_020190 ENOG4107T32 3-phytase (EC 3.1.3.8) AW03_020200 ENOG4105C5E polysaccharide biosynthesis protein AW03_020210 ENOG4105E0X reductase AW03_020220 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) AW03_020260 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) AW03_020270 ENOG41090WU lipolytic protein G-D-S-L family AW03_020280 ENOG4108KF3 Electron transport protein SCO1 SenC AW03_020300 ENOG4105C7B Threonine dehydratase AW03_020320 ENOG4108UT2 hemolysin iii AW03_020340 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) AW03_020350 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) AW03_020380 ENOG4107YX5 Pfam:DUF548 AW03_020390 ENOG4108Y6J UPF0403 protein AW03_020400 ENOG4105C01 Dihydroxy-acid dehydratase AW03_020440 ENOG4108V06 Glutathione peroxidase AW03_020450 ENOG4105CVG Homoserine O-transsuccinylase AW03_020530 ENOG41081VK Ribonuclease AW03_020580 ENOG410890F Dynamin family AW03_020600 ENOG41065KQ synthase AW03_020610 ENOG4105C2W permease AW03_020620 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) AW03_020630 ENOG4105CTD carboxy-peptidase AW03_020640 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) AW03_020650 ENOG4108UHU Aldolase AW03_020660 ENOG4105D7K pfkb domain protein AW03_020670 ENOG4108M60 Transcriptional regulator AW03_020690 ENOG4105CHR reductase AW03_020700 ENOG4105DVT helicase AW03_020720 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AW03_020740 ENOG4108UKS UPF0398 protein AW03_020750 ENOG4107X2U Inherit from COG: Exonuclease-like protein AW03_020760 ENOG4108I5C dEAD DEAH box helicase AW03_020860 ENOG4105BZ4 penicillin-binding protein AW03_020880 ENOG4105CSM endonuclease III AW03_020900 ENOG4105C5S asparaginyl-tRNA synthetase AW03_020910 ENOG4105CHM Aminotransferase AW03_020930 ENOG4105YAC AW03_020940 ENOG4105DVT helicase AW03_020950 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) AW03_020960 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) AW03_020970 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) AW03_020980 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase AW03_020990 ENOG4105DJ0 Poly(A) Polymerase AW03_021000 ENOG4105CPK Glycosyl transferase (Group 1 AW03_021010 ENOG4105FJR Lmbe family AW03_021020 ENOG4108Z5K methylglyoxal synthase AW03_021030 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) AW03_021040 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase AW03_021050 ENOG4108JYZ YitT family AW03_021090 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) AW03_021130 ENOG41068YB TPR repeat-containing protein AW03_021140 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase AW03_021160 ENOG4105CIH Imidazole acetol-phosphate transaminase AW03_021180 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) AW03_021190 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase AW03_021210 ENOG4108I0Q anthranilate phosphoribosyltransferase AW03_021220 ENOG4105CRQ synthase (Component I) AW03_021230 ENOG4105KHN chorismate mutase AW03_021240 ENOG4105D49 3-dehydroquinate synthase AW03_021250 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase AW03_021260 ENOG4105BZU Histidine kinase AW03_021270 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) AW03_021280 ENOG4105EAH synthase AW03_021290 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) AW03_021300 ENOG4105XXQ heptaprenyl diphosphate synthase component I AW03_021320 ENOG4105EUJ GTP cyclohydrolase i AW03_021330 ENOG4105K70 DNA-binding protein AW03_021340 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) AW03_021370 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase AW03_021380 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) AW03_021390 ENOG41065D1 AW03_021400 ENOG4105S2F AW03_021430 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) AW03_021440 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AW03_021450 ENOG4105CAT Cytidine monophosphate kinase AW03_021480 ENOG4105MSI germination protein ypeb AW03_021500 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) AW03_021510 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase AW03_021540 ENOG4107RGJ metallophosphoesterase AW03_021570 ENOG4105I7S Abortive infection protein AW03_021580 ENOG4105C9U ATP-dependent DNA helicase RecQ AW03_021590 ENOG4105T7X AW03_021610 ENOG4108SAX Membrane AW03_021620 ENOG4108JQ1 Dehydrogenase AW03_021630 ENOG4105FF2 Type I DHQase AW03_021660 ENOG4105BZU Histidine kinase AW03_021670 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW03_021680 ENOG4105CRE cytochrome C AW03_021690 ENOG4107TWT Cytochrome c biogenesis protein AW03_021710 ENOG4105FE9 pseudouridine synthase AW03_021730 ENOG4108JIC nucleoside recognition domain protein AW03_021740 ENOG4105DZ1 carboxypeptidase AW03_021760 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) AW03_021770 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) AW03_021800 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AW03_021810 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) AW03_021820 ENOG4108R6K riboflavin synthase, subunit alpha AW03_021830 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AW03_021850 ENOG4105C3F Signal peptidase i AW03_021860 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) AW03_021880 ENOG4107ZE5 PPIases accelerate the folding of proteins AW03_021890 ENOG4105PTM secreted protein AW03_021900 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AW03_021920 ENOG4105G6R Stage v sporulation protein ae AW03_021940 ENOG4105CZ3 stage V sporulation protein ad AW03_021950 ENOG41090VF Stage v sporulation protein ac AW03_021980 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW03_021990 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) AW03_022000 ENOG41082AN stage II sporulation protein AW03_022010 ENOG4105DZ1 carboxypeptidase AW03_022020 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) AW03_022030 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) AW03_022040 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AW03_022060 ENOG4105I3K Ferric uptake regulator, Fur family AW03_022070 ENOG4105MZ9 stage II sporulation protein m AW03_022100 ENOG4105DFD Na H antiporter AW03_022110 ENOG4108IJ0 Aspartate ammonia-lyase AW03_022120 ENOG4105HDK L-asparaginase AW03_022130 ENOG4108IMY Transcriptional regulator AW03_022150 ENOG4108YZ4 nudix hydrolase AW03_022170 ENOG4105CPC Aldo Keto reductase AW03_022210 ENOG4106HZJ AW03_022220 ENOG4105RHY Pfam:UPF0157 AW03_022230 ENOG4105KAC Antibiotic biosynthesis monooxygenase AW03_022240 ENOG4108XET gCN5-related N-acetyltransferase AW03_022260 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AW03_022280 ENOG4105E5W Transporter AW03_022300 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase AW03_022330 ENOG4108IXY short-chain dehydrogenase reductase AW03_022340 ENOG41069FQ Metallo-beta-lactamase superfamily AW03_022350 ENOG4105II7 pyrroline-5-carboxylate reductase AW03_022370 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AW03_022390 ENOG410861F 50S ribosomal protein L33 AW03_022400 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) AW03_022410 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AW03_022420 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AW03_022430 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AW03_022450 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) AW03_022460 ENOG4108NA0 Uncharacterized conserved protein (COG2071) AW03_022470 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AW03_022480 ENOG4108HNZ carboxyl transferase AW03_022490 ENOG4108ZVT methylmalonyl-coA epimerase AW03_022510 ENOG4108VZI ErfK ybiS ycfS ynhG family protein AW03_022520 ENOG4108QEG Membrane AW03_022530 ENOG4105CDA abc transporter atp-binding protein AW03_022540 ENOG4105E5Q amino acid AbC transporter AW03_022550 ENOG4108HW3 (ABC) transporter AW03_022560 ENOG4108Y6J UPF0403 protein AW03_022570 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) AW03_022600 ENOG4105C7S Dehydrogenase AW03_022610 ENOG4105CPP Dehydrogenase, E1 component AW03_022640 ENOG4105CKM Branched-chain carboxylic acid kinase AW03_022650 ENOG4107RDP Dehydrogenase AW03_022670 ENOG4108JUB Transcriptional regulator AW03_022680 ENOG4106CCJ Protein of unknown function (DUF2627) AW03_022690 ENOG4105CR4 methylisocitrate lyase AW03_022700 ENOG4105DXD 2-methylcitrate dehydratase AW03_022720 ENOG4105C1G acyl-Coa dehydrogenase AW03_022730 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AW03_022750 ENOG4108QXE glycerophosphoryl diester phosphodiesterase AW03_022760 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AW03_022780 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AW03_022800 ENOG4107QQR Sporulation AW03_022810 ENOG4105S1Z Stage IV sporulation protein B AW03_022820 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AW03_022830 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) AW03_022840 ENOG4105DX0 Hemolysin A AW03_022860 ENOG4105CTB Polyprenyl synthetase AW03_022870 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AW03_022880 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) AW03_022890 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) AW03_022900 ENOG4105M7K Involved in the transcription termination process (By similarity) AW03_022910 ENOG4108ZSR alkaline shock protein AW03_022920 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AW03_022960 ENOG410644B Stage III sporulation protein af AW03_022980 ENOG4105KQ4 Stage iii sporulation protein ad AW03_022990 ENOG4108CQH stage III sporulation protein AC AW03_023000 ENOG4105KR5 Stage iii sporulation protein AW03_023010 ENOG4105CD2 stage iii sporulation protein aa AW03_023030 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) AW03_023040 ENOG4105DC7 peptidase M24 AW03_023050 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) AW03_023070 ENOG4105CBJ Metal-dependent enzyme AW03_023100 ENOG4105KST dependent repressor AW03_023110 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) AW03_023120 ENOG4105WZW rhodanese family AW03_023130 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AW03_023140 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor AW03_023150 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) AW03_023160 ENOG4105C0D helicase AW03_023190 ENOG4108IMY Transcriptional regulator AW03_023210 ENOG4105VFR signal peptidase AW03_023330 ENOG4105C37 (CBS) domain AW03_023370 ENOG4105C5X domain protein AW03_023420 ENOG4105E0M Sulfatase AW03_023450 ENOG4107ZXI Rhomboid family AW03_023470 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AW03_023480 ENOG4105WDJ 50S ribosomal protein L33 AW03_023520 ENOG41068DG YceG-like family AW03_023530 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AW03_023540 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AW03_023550 ENOG4105E2Z phosphate ABC transporter (Permease AW03_023560 ENOG4105C8U phosphate abc transporter AW03_023570 ENOG4105CVA phosphate AW03_023580 ENOG4107RF6 penicillin-binding protein AW03_023600 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AW03_023610 ENOG4105SXS Protein of unknown function (DUF456) AW03_023640 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) AW03_023650 ENOG41063Y9 AW03_023660 ENOG4108U5J '-nucleotidase AW03_023670 ENOG4105N80 Ferric uptake regulator, Fur family AW03_023680 ENOG4108JYZ YitT family AW03_023690 ENOG41069ZM Protein of unknown function (DUF2624) AW03_023700 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) AW03_023730 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) AW03_023740 ENOG4105EGD dinuclear metal center protein, YbgI family AW03_023770 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW03_023780 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AW03_023790 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 AW03_023800 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) AW03_023820 ENOG4105C38 Glycyl-tRNA synthetase beta subunit AW03_023830 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit AW03_023840 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) AW03_023860 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) AW03_023870 ENOG4105KG3 cytidine deaminase AW03_023880 ENOG4107YR5 Diacylglycerol kinase AW03_023890 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) AW03_023900 ENOG4105CTJ Metal Dependent Phosphohydrolase AW03_023920 ENOG4105C9A Phoh family AW03_023930 ENOG4105EI1 sporulation protein yqfd AW03_023940 ENOG41068P3 sporulation protein YqfC AW03_023960 ENOG4105DI5 UPF0365 protein AW03_023970 ENOG4105F7J membrane-bound serine protease AW03_023980 ENOG4105KTH gatB Yqey AW03_024010 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) AW03_024020 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AW03_024030 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) AW03_024050 ENOG4105CFG Acts as a chaperone (By similarity) AW03_024060 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ AW03_024070 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) AW03_024080 ENOG4105CSA Coproporphyrinogen iii oxidase AW03_024090 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) AW03_024110 ENOG4108ZRV stage ii sporulation protein p AW03_024120 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) AW03_024130 ENOG41082YS Binds directly to 16S ribosomal RNA AW03_024150 ENOG4105TQK DNA polymerase iii, delta' subunit AW03_024170 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 AW03_024180 ENOG4108UK2 deaminase AW03_024190 ENOG4105KQC Competence protein AW03_024210 ENOG4108D32 Methyltransferase AW03_024230 ENOG4108WF2 Metal Dependent Phosphohydrolase AW03_024240 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) AW03_024250 ENOG410812S Rna-binding protein AW03_024260 ENOG4105E2X shikimate dehydrogenase AW03_024270 ENOG4105CQW ribosome biogenesis GTPase YqeH AW03_024280 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase AW03_024310 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase AW03_024320 ENOG41080BT SNARE associated Golgi AW03_024350 ENOG4105WFK nuclease AW03_024360 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW03_024390 ENOG4108SWU Histidine kinase AW03_024400 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW03_024410 ENOG4105DHF Membrane AW03_024420 ENOG4108UYN gCN5-related N-acetyltransferase AW03_024440 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr AW03_024490 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase AW03_024540 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) AW03_024570 ENOG4107Y5K Resolvase AW03_024580 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AW03_024590 ENOG41068VA AW03_024600 ENOG4105RV9 Transcriptional regulator AW03_024610 ENOG41082J7 Rhodanese domain protein AW03_024700 ENOG41090E6 transcriptional regulator MERR family AW03_024730 ENOG4105C37 (CBS) domain AW03_024760 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family AW03_024770 ENOG4105H3G oxidoreductase AW03_024780 ENOG4105PGM cation diffusion facilitator family transporter AW03_024790 ENOG41090U3 tautomerase AW03_024820 ENOG4105KMT branched-chain amino acid AW03_024830 ENOG4108UMN azlc family AW03_024840 ENOG4108ZRZ Transcriptional regulator (AsnC family) AW03_024850 ENOG41067XF inhibitor AW03_024880 ENOG41064BW Protein of unknown function (DUF2568) AW03_024910 ENOG41075D4 Aminoglycoside 6-adenylyltransferase AW03_024920 ENOG4105EA8 2-Nitropropane dioxygenase AW03_024930 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AW03_024950 ENOG4108MEK Metal-binding protein YodA AW03_024960 ENOG410904A RNA polymerase AW03_024970 ENOG4105CPC Aldo Keto reductase AW03_024980 ENOG41083Q9 chitosanase AW03_024990 ENOG4105X5K response regulator receiver protein AW03_025000 ENOG4108VQT Alpha beta hydrolase fold protein AW03_025010 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein AW03_025020 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein AW03_025030 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase AW03_025050 ENOG4105PGS Spore coat protein AW03_025060 ENOG4105E2A Dehydrogenase AW03_025090 ENOG4105VUF Transcriptional regulator AW03_025110 ENOG4105DQ4 alcohol dehydrogenase AW03_025120 ENOG4108Z0Z intracellular protease Pfpi family AW03_025130 ENOG4108HKT sucrose-6-phosphate hydrolase AW03_025140 ENOG4105F3R pts system mannose fructose sorbose family iid AW03_025150 ENOG4105ETZ PTS System AW03_025160 ENOG4108IQ3 PTS system AW03_025170 ENOG4105YHU PTS system AW03_025180 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AW03_025190 ENOG4105C85 amino acid AW03_025200 ENOG4105N14 lysine exporter protein LysE YggA AW03_025210 ENOG4108NGU Transcriptional regulator AW03_025220 ENOG4105JVQ RNA Polymerase AW03_025230 ENOG4108P49 AntiSigma factor AW03_025240 ENOG4105EXC Acyl-transferase AW03_025250 ENOG4105WDR AW03_025260 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AW03_025270 ENOG41082JN Transcriptional regulator AW03_025310 ENOG4105TMB Formate nitrite transporter AW03_025320 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) AW03_025330 ENOG4108JB9 formate dehydrogenase AW03_025360 ENOG4105C28 cystathionine AW03_025390 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) AW03_025420 ENOG4107XRG penicillin-binding protein AW03_025430 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AW03_025440 ENOG4105DBI uridine monophosphokinase AW03_025450 ENOG4105CFP Peptidase U32 AW03_025460 ENOG4105XYU peptidase (U32 family) AW03_025470 ENOG4108VQJ O-methyltransferase AW03_025480 ENOG4105HHA aminodeoxychorismate lyase AW03_025490 ENOG4105VPH UPF0473 protein AW03_025500 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) AW03_025510 ENOG4105VBH UPF0297 protein AW03_025520 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AW03_025530 ENOG4105C02 permease AW03_025540 ENOG4105CDA abc transporter atp-binding protein AW03_025550 ENOG4105CT1 (ABC) transporter AW03_025560 ENOG4105EAD ABC transporter AW03_025570 ENOG4105DRP amino acid AbC transporter AW03_025590 ENOG41060CR AW03_025610 ENOG4105C7H Helicase, RecD TraA family AW03_025630 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) AW03_025640 ENOG4105C3J Cysteine desulfurase AW03_025660 ENOG4105D1H recombination factor protein RarA AW03_025670 ENOG4105CUZ uba thif-type nad fad binding protein AW03_025680 ENOG4105C9M aspartyl-trna synthetase AW03_025690 ENOG4105CUT histidyl-tRNA synthetase AW03_025710 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AW03_025730 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AW03_025740 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) AW03_025750 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AW03_025760 ENOG41067VP Protein of unknown function (DUF1049) AW03_025770 ENOG4105NCW Trka-c domain protein AW03_025780 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AW03_025800 ENOG4105CKP Polysaccharide Biosynthesis Protein AW03_025810 ENOG4108QG2 Membrane AW03_025820 ENOG4105NAP AW03_025830 ENOG4105VIE preprotein translocase, subunit YajC AW03_025840 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) AW03_025850 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) AW03_025860 ENOG41061AI Protein of unknown function (DUF2905) AW03_025870 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) AW03_025880 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) AW03_025900 ENOG4105IE8 Alpha-ketoglutarate permease AW03_025910 ENOG4105CK5 oxidoreductase AW03_025950 ENOG4105BZG amino acid carrier protein AW03_025960 ENOG4105CDY transcriptional regulatory protein AW03_025980 ENOG4106678 morphogenetic protein associated with SpoVID AW03_025990 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) AW03_026000 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AW03_026010 ENOG4108IYU L-aspartate oxidase AW03_026040 ENOG4105CQC Prephenate dehydratase AW03_026050 ENOG41090I5 UPF0735 ACT domain-containing protein AW03_026060 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AW03_026080 ENOG4105K46 50S ribosomal protein l27 AW03_026090 ENOG4105X36 (ribosomal) protein AW03_026100 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) AW03_026130 ENOG4107QMS site-determining protein AW03_026140 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) AW03_026150 ENOG4105YHC Rod shape-determining protein MreD AW03_026160 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AW03_026170 ENOG4105DFF Rod shape-determining protein mreb AW03_026190 ENOG4105W5Q DNA repair protein (RadC AW03_026200 ENOG4108Z03 MAF-like protein AW03_026220 ENOG4106A3R peptidase AW03_026230 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AW03_026240 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AW03_026260 ENOG4106AR7 Spore coat protein AW03_026270 ENOG41068KH stage VI sporulation protein D AW03_026280 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase AW03_026290 ENOG4105D52 delta-aminolevulinic acid dehydratase AW03_026310 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) AW03_026330 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AW03_026350 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) AW03_026360 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) AW03_026370 ENOG4108IUQ atp-dependent protease AW03_026380 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) AW03_026390 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation AW03_026410 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AW03_026420 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) AW03_026430 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AW03_026440 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) AW03_026450 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase AW03_026460 ENOG4108ZP8 Acetolactate synthase small subunit AW03_026470 ENOG4105C7K acetolactate synthase AW03_026490 ENOG4105I4A GCN5-related N-acetyltransferase AW03_026500 ENOG4107KM7 Heat induced stress protein YflT AW03_026510 ENOG4105M59 Phosphodiesterase, mj0936 family AW03_026520 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AW03_026530 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) AW03_026540 ENOG4108XJQ germination protein AW03_026550 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) AW03_026560 ENOG41067TZ transcriptional regulator, MarR family AW03_026570 ENOG4105PFC Transcriptional regulator AW03_026590 ENOG4105E33 succinate dehydrogenase AW03_026610 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit AW03_026630 ENOG4105CFH Aspartokinase AW03_026640 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) AW03_026650 ENOG4105K63 Thioredoxin AW03_026660 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) AW03_026680 ENOG4105C10 Electron transfer flavoprotein AW03_026690 ENOG4105BZJ Electron transfer flavoprotein AW03_026700 ENOG41060WC Enoyl-CoA hydratase AW03_026710 ENOG4107Z3H Transcriptional regulator, TetR family AW03_026720 ENOG4105CEY Amp-dependent synthetase and ligase AW03_026740 ENOG4105C98 muts2 protein AW03_026750 ENOG4105DCG PHP domain protein AW03_026780 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) AW03_026790 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AW03_026800 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) AW03_026810 ENOG4108RWN rrna methyltransferase AW03_026820 ENOG41067MF small acid-soluble spore protein AW03_026840 ENOG4105CQB FAD linked oxidase domain protein AW03_026850 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AW03_026880 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) AW03_026890 ENOG4105DRS transport system, permease AW03_026920 ENOG4108MDK Dehydrogenase AW03_026940 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase AW03_026950 ENOG4105EF1 ribulokinase AW03_026970 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase AW03_026980 ENOG4105CN9 Peptidase m42 family protein AW03_027000 ENOG410696E Membrane AW03_027010 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AW03_027020 ENOG4105VJV 50s ribosomal protein L35 AW03_027030 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) AW03_027050 ENOG41067MG lrgb family AW03_027070 ENOG4105DY9 regulatoR AW03_027080 ENOG4108HRK Histidine kinase AW03_027090 ENOG4105U0R haloacid dehalogenase-like hydrolase AW03_027100 ENOG4105C22 threonyL-tRNA synthetase AW03_027110 ENOG4108TDW sporulation protein YtxC AW03_027150 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) AW03_027160 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) AW03_027170 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AW03_027180 ENOG4105KVH Transcriptional regulator AW03_027190 ENOG4105F27 Major Facilitator AW03_027200 ENOG4105CV8 reductase AW03_027210 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AW03_027230 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) AW03_027240 ENOG4105C2M dna polymerase I AW03_027250 ENOG4105BZU Histidine kinase AW03_027260 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW03_027270 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) AW03_027280 ENOG4108HMX isocitrate dehydrogenase (NADP) AW03_027290 ENOG4105BZN citrate synthase AW03_027310 ENOG4108REF Sporulation integral membrane protein ytvi AW03_027320 ENOG4105FS0 cytoplasmic membrane protein AW03_027330 ENOG4105CA9 Pyruvate kinase AW03_027340 ENOG4105CTQ phosphohexokinase AW03_027360 ENOG4108IEY Carboxyl transferase domain AW03_027370 ENOG4105C6K Malic enzyme AW03_027380 ENOG4105C0B DNA polymerase III (alpha subunit) AW03_027390 ENOG4105VV2 AW03_027410 ENOG4106EVM AW03_027420 ENOG4105SFS phosphoesterase RecJ domain protein AW03_027450 ENOG410635A Membrane AW03_027460 ENOG4105CH2 amidohydrolase AW03_027500 ENOG4105DEN Luciferase family AW03_027510 ENOG4105CDA abc transporter atp-binding protein AW03_027560 ENOG4108XSB acetyltransferase, (GNAT) family AW03_027570 ENOG4108KSA LysR family transcriptional regulator AW03_027580 ENOG4105E8R UPF0173 metal-dependent hydrolase AW03_027610 ENOG4105CH7 arginosuccinase AW03_027620 ENOG4105CDH Citrulline--aspartate ligase AW03_027630 ENOG4105EPU Molybdenum cofactor synthesis domain protein AW03_027640 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AW03_027660 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AW03_027670 ENOG4105KBJ sporulation protein ytfj AW03_027690 ENOG4105VK3 rdd domain containing protein AW03_027700 ENOG4105D07 Signal peptide peptidase, SppA AW03_027710 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) AW03_027720 ENOG4105EFZ amidohydrolase AW03_027730 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AW03_027800 ENOG4105U5Y Transcriptional regulator AW03_027820 ENOG4105BZU Histidine kinase AW03_027830 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AW03_027850 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AW03_027870 ENOG4105F1V Acetoin utilization protein AW03_027880 ENOG4105W87 Cbs domain AW03_027890 ENOG4105DGU Histone deacetylase AW03_027900 ENOG4105ER2 Ompa motb domain protein AW03_027910 ENOG4107R0U MotA TolQ exbB proton channel AW03_027920 ENOG4105ETE Transcriptional regulator (LacI family AW03_027930 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase AW03_027970 ENOG4105DFU Cell wall formation (By similarity) AW03_027990 ENOG4108VDD TRNA binding domain protein AW03_028020 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ AW03_028050 ENOG4105C6K Malic enzyme AW03_028060 ENOG4105C8F Beta-lactamase domain protein AW03_028070 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) AW03_028090 ENOG4108V15 phosphotransferase enzyme family AW03_028100 ENOG4108IUM Glycogen debranching enzyme AW03_028130 ENOG4107F58 2'-5' rna ligase AW03_028140 ENOG4105C6T cysteine synthase AW03_028150 ENOG4107QSE Dipeptidase AW03_028160 ENOG4105C7N Xanthine uracil vitamin C permease AW03_028190 ENOG4105YW5 deoR family transcriptional regulator AW03_028220 ENOG4105CBX hi0933 family AW03_028230 ENOG4105C94 Transporter AW03_028250 ENOG4105MU9 integral membrane protein AW03_028260 ENOG4105DDC Oxidoreductase domain protein AW03_028280 ENOG4105F5H Glycosyl Hydrolase Family 88 AW03_028300 ENOG41075H3 AraC family transcriptional regulator AW03_028320 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component AW03_028340 ENOG4106A3M Cytochrome p-450 AW03_028350 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) AW03_028370 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AW03_028380 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AW03_028400 ENOG4105NTD Inherit from COG: Hydrolase AW03_028430 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component AW03_028440 ENOG4105I1K ABC transporter AW03_028460 ENOG41085GJ domain protein AW03_028470 ENOG4105C8T Leucyl-tRNA synthetase AW03_028490 ENOG4105BZU Histidine kinase AW03_028500 ENOG410605W Major Facilitator AW03_028510 ENOG4106UBQ AW03_028530 ENOG4105C19 ABC transporter AW03_028540 ENOG4105EWM Histidine kinase AW03_028560 ENOG4107R34 abc transporter permease protein AW03_028570 ENOG4105C19 ABC transporter AW03_028600 ENOG4105DVE abc transporter atp-binding protein AW03_028610 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family AW03_028640 ENOG4105N5T Radical SAM Protein AW03_028670 ENOG4105E8V Alpha Beta Hydrolase Fold protein AW03_028680 ENOG4108Z0R Transferase AW03_028690 ENOG4105C85 amino acid AW03_028700 ENOG4105CAQ asparagine synthetase AW03_028710 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AW03_028720 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase AW03_028750 ENOG4105D2X ABC transporter substrate-binding protein AW03_028770 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component AW03_028800 ENOG4108RMU ferritin dps family protein AW03_028830 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) AW03_028840 ENOG4108V2W Carbonate dehydratase AW03_028890 ENOG4105CC5 ABC transporter AW03_028900 ENOG4105CC5 ABC transporter AW03_028910 ENOG4105DIK (ABC) transporter AW03_028920 ENOG4105DSE periplasmic solute binding protein AW03_028930 ENOG4105DTQ mandelate racemase muconate lactonizing AW03_028940 ENOG4105CEY Amp-dependent synthetase and ligase AW03_028950 ENOG4108IPT Naphthoate synthase AW03_028960 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) AW03_028970 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) AW03_028980 ENOG4105E4F Isochorismate synthase AW03_029020 ENOG4108IAJ Nad-dependent epimerase dehydratase AW03_029030 ENOG4107SBE Glycosyl transferase (Group 1 AW03_029060 ENOG4107SBE Glycosyl transferase (Group 1 AW03_029070 ENOG4108KS4 Spore coat protein AW03_029100 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) AW03_029120 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) AW03_029150 ENOG4105N67 Proton-coupled thiamine transporter YuaJ AW03_029160 ENOG4105VRR gCN5-related N-acetyltransferase AW03_029170 ENOG4105VRR gCN5-related N-acetyltransferase AW03_029180 ENOG4105DZ6 Band 7 protein AW03_029200 ENOG4106DF1 AW03_029210 ENOG4108VNY MOSC domain protein AW03_029220 ENOG4108JB8 alcohol dehydrogenase AW03_029230 ENOG4105C26 Dehydrogenase AW03_029240 ENOG4105TRT Transcriptional regulator AW03_029270 ENOG4105CZN Potassium uptake protein AW03_029280 ENOG4107I77 yiaA/B two helix domain AW03_029290 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj AW03_029320 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AW03_029340 ENOG4105EE0 oxidoreductase AW03_029350 ENOG4105DKG l-rhamnose isomerase AW03_029360 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) AW03_029370 ENOG4105DET Rhamnulokinase AW03_029380 ENOG4105E98 transcriptional regulator DeoR family AW03_029400 ENOG4105C8Q Methyl-accepting chemotaxis AW03_029410 ENOG4105C8Q Methyl-accepting chemotaxis AW03_029420 ENOG4105C8Q Methyl-accepting chemotaxis AW03_029430 ENOG4105C8Q Methyl-accepting chemotaxis AW03_029460 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme AW03_029480 ENOG4105C37 (CBS) domain AW03_029510 ENOG4107PBV potassium channel AW03_029520 ENOG4107PBV potassium channel AW03_029550 ENOG4107QYV phosphohexose isomerase AW03_029570 ENOG4107QW4 alcohol dehydrogenase AW03_029580 ENOG4105WG9 Conserved Protein AW03_029600 ENOG4105CHM Aminotransferase AW03_029610 ENOG4108ZB6 transcriptional regulator AsnC family AW03_029620 ENOG4108MUZ hydrolase AW03_029640 ENOG4105C87 Aminotransferase class I and II AW03_029650 ENOG4108HGU Histidine kinase AW03_029660 ENOG4105Y38 Kinase-associated protein B AW03_029700 ENOG4105BZ4 penicillin-binding protein AW03_029710 ENOG4105KIR Thiol-disulfide oxidoreductase dcc AW03_029740 ENOG4108MRH transcriptional regulatory protein AW03_029750 ENOG4105DIH basic membrane AW03_029760 ENOG4108JQ9 ABC transporter AW03_029770 ENOG4105UIB (ABC) transporter AW03_029810 ENOG4105D65 subunit l AW03_029820 ENOG4105HC0 Na H antiporter AW03_029830 ENOG4108ZE9 Monovalent cation H antiporter subunit C AW03_029840 ENOG4108JPZ Monovalent cation H antiporter subunit D AW03_029850 ENOG4105SC1 monovalent cation H antiporter subunit E AW03_029870 ENOG4105KJM monovalent cation h antiporter subunit g AW03_029880 ENOG4105KA0 thioesterase Superfamily protein AW03_029900 ENOG4105BZU Histidine kinase AW03_029950 ENOG4105D58 Diguanylate phosphodiesterase AW03_029960 ENOG4105DAP Nicotinate phosphoribosyltransferase AW03_030020 ENOG4105C02 permease AW03_030060 ENOG410904N short-chain dehydrogenase reductase AW03_030130 ENOG4108K8K Transcriptional regulator AW03_030140 ENOG4105DCF alanine dehydrogenase AW03_030160 ENOG4105WQT MbtH domain protein AW03_030170 ENOG4105CEY Amp-dependent synthetase and ligase AW03_030180 ENOG4105WQI isochorismatase AW03_030190 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AW03_030200 ENOG4105E4F Isochorismate synthase AW03_030210 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AW03_030220 ENOG4105NIV Esterase AW03_030260 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) AW03_030280 ENOG41069ER domain protein AW03_030300 ENOG4105CEP NADH dehydrogenase AW03_030310 ENOG4105CAY ferredoxin--nadp reductase AW03_030350 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 AW03_030360 ENOG4108YX9 iron--sulfur cluster insertion protein erpA AW03_030390 ENOG4105ZKE UPF0349 protein AW03_030420 ENOG41083MR nifu domain-containing protein AW03_030430 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein AW03_030440 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) AW03_030450 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) AW03_030460 ENOG4105D6E homoserine dehydrogenase AW03_030480 ENOG4108W5N phosphatidylglycerophosphatase a AW03_030490 ENOG4105D4U had-superfamily hydrolase, subfamily iia AW03_030510 ENOG4105MMD transcriptional regulator AW03_030520 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) AW03_030530 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) AW03_030540 ENOG4105FAA peptidase M23 AW03_030550 ENOG4108YTE sporulation protein YunB AW03_030560 ENOG4105KZD Domain of unknown function (DUF1805) AW03_030570 ENOG4107R8B 5'-nucleotidase AW03_030590 ENOG4105I3N Conserved Protein AW03_030610 ENOG4105CD3 dihydroorotase AW03_030620 ENOG4105G9B Transcriptional regulator AW03_030650 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) AW03_030660 ENOG4105VT2 5-hydroxyisourate hydrolase AW03_030670 ENOG4107YV9 domain protein AW03_030680 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding AW03_030710 ENOG4105XRQ Xanthine dehydrogenase accessory factor AW03_030730 ENOG4105C5R Aminotransferase AW03_030750 ENOG4108K8S endonuclease I AW03_030760 ENOG4108IJ9 (ABC) transporter AW03_030770 ENOG4105FDP GntR family transcriptional regulator AW03_030780 ENOG4108KPW sugar kinase AW03_030790 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component AW03_030800 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component AW03_030810 ENOG4105XN3 extracellular solute-binding protein family 1 AW03_030820 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine AW03_030830 ENOG4105PKS Excinuclease abc c subunit domain protein AW03_030840 ENOG4107VFR oxidoreductase AW03_030870 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase AW03_030880 ENOG4105DIW FeS assembly protein SUFB AW03_030890 ENOG4108UNV SUF system FeS assembly protein, NifU family AW03_030900 ENOG4105C9B Cysteine desulfurase AW03_030910 ENOG4105JRK feS assembly protein SufD AW03_030920 ENOG4105C3K feS assembly ATPase SufC AW03_030940 ENOG4105D01 (LipO)protein AW03_030950 ENOG4108UMI ABC transporter, permease AW03_030960 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AW03_031010 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) AW03_031020 ENOG41080E8 Transcriptional regulator, Spx MgsR family AW03_031030 ENOG4105C1G acyl-Coa dehydrogenase AW03_031040 ENOG4105CHU acetyl-coa acetyltransferase AW03_031100 ENOG41067TZ transcriptional regulator, MarR family AW03_031110 ENOG4105C0R drug resistance transporter emrb qaca subfamily AW03_031120 ENOG4105MDS 4-oxalocrotonate tautomerase AW03_031140 ENOG4105EGI Transcriptional regulator AW03_031160 ENOG4105E0A ABC, transporter AW03_031190 ENOG4105E1F short-chain dehydrogenase reductase AW03_031200 ENOG4105HUF DNA protection during starvation protein AW03_031210 ENOG4105C0H protease AW03_031230 ENOG4105F3H Histidine kinase AW03_031240 ENOG41067SE Tetr family transcriptional regulator AW03_031250 ENOG4105C9Q fumarate hydratase class II AW03_031300 ENOG4105WH1 Two component transcriptional regulator luxr family AW03_031310 ENOG4105ENE Histidine kinase AW03_031340 ENOG41087YS Phage shock protein A AW03_031370 ENOG4108WBT adenosyltransferase AW03_031380 ENOG4105E0A ABC, transporter AW03_031390 ENOG4105EHG Permease protein AW03_031400 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AW03_031410 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AW03_031420 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein AW03_031440 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AW03_031460 ENOG4106DF4 Sigma-70, region 4 AW03_031480 ENOG4105F0F Oxalate decarboxylase AW03_031500 ENOG4107RBB ABC transporter, permease AW03_031510 ENOG4105C19 ABC transporter AW03_031520 ENOG4108WMK Efflux transporter RND family MFP subunit AW03_031530 ENOG4105E0A ABC, transporter AW03_031540 ENOG4105EHG Permease protein AW03_031550 ENOG4105DQ5 transport system permease protein AW03_031570 ENOG4105D5Q Arginine ornithine antiporter AW03_031590 ENOG4107K5X Membrane-bound metal-dependent hydrolase AW03_031600 ENOG4107QZ2 Sulfatase AW03_031610 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family AW03_031620 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AW03_031630 ENOG4105E0C molybdate abc transporter AW03_031660 ENOG4105EEQ Na H antiporter AW03_031670 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) AW03_031680 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) AW03_031690 ENOG4105EEM helicase AW03_031710 ENOG4105EN6 Membrane AW03_031730 ENOG4107ZQN disulfide bond AW03_031740 ENOG4105C59 p-type ATPase AW03_031750 ENOG4105C59 p-type ATPase AW03_031760 ENOG410681U heavy metal transport detoxification protein AW03_031770 ENOG4105VPX protein, conserved in bacteria AW03_031780 ENOG4105D9R oxidoreductase AW03_031790 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) AW03_031800 ENOG4105ME7 Membrane AW03_031810 ENOG4105RXJ AW03_031820 ENOG4105KPY Small multidrug resistance protein AW03_031830 ENOG4105KBX Transcriptional regulator, TetR family AW03_031840 ENOG4105EWI Short-chain dehydrogenase reductase Sdr AW03_031850 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) AW03_031860 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AW03_031880 ENOG4105XZU Preprotein translocase, subunit SecG AW03_031930 ENOG4105KVH Transcriptional regulator AW03_031970 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin AW03_031980 ENOG4105R40 Glycine betaine carnitine choline AW03_031990 ENOG4108HQR Glycine betaine AW03_032000 ENOG4105E90 ABC transporter AW03_032010 ENOG4108IJ8 ABC transporter AW03_032020 ENOG4107HG4 Transcriptional regulator AW03_032030 ENOG4105R40 Glycine betaine carnitine choline AW03_032040 ENOG4108HQR Glycine betaine AW03_032050 ENOG4105E90 ABC transporter AW03_032060 ENOG4108IJ8 ABC transporter AW03_032070 ENOG4107HG4 Transcriptional regulator AW03_032080 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein AW03_032090 ENOG4108QCI YvbH-like oligomerisation region AW03_032110 ENOG4105T65 Membrane-associated protein AW03_032120 ENOG4108W0I acetyltransferase AW03_032150 ENOG4105FJR Lmbe family AW03_032190 ENOG4108IAJ Nad-dependent epimerase dehydratase AW03_032200 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AW03_032210 ENOG4107QQG Dehydrogenase AW03_032220 ENOG4105IIU Aminopeptidase AW03_032230 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AW03_032240 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) AW03_032250 ENOG4105CP7 Triose-phosphate isomerase AW03_032260 ENOG4105BZA Phosphoglycerate kinase AW03_032270 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AW03_032300 ENOG4105CMD Transcriptional regulator, GntR family AW03_032310 ENOG4105DEN Luciferase family AW03_032320 ENOG4105GZI Transcriptional regulator AW03_032330 ENOG4107RT3 EamA-like transporter family AW03_032350 ENOG4105VRS hydrolase family 18 AW03_032360 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) AW03_032370 ENOG4107QR9 Iron-sulfur cluster binding protein AW03_032380 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AW03_032400 ENOG4105BZU Histidine kinase AW03_032410 ENOG4105KCT ABC transporter AW03_032420 ENOG4108M15 ABC transporter AW03_032430 ENOG4107R6F Alpha Beta Hydrolase Fold protein AW03_032440 ENOG4108MJI response regulator AW03_032470 ENOG4105EG2 ABC transporter, permease AW03_032490 ENOG4107FKK extracellular solute-binding protein family 1 AW03_032510 ENOG4105JXH GntR family transcriptional regulator AW03_032520 ENOG4105DAA L-lactate AW03_032530 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AW03_032550 ENOG4108ZPC Polysaccharide pyruvyl transferase AW03_032560 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AW03_032570 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family AW03_032580 ENOG4105D3Q Sugar transferase AW03_032600 ENOG4105K64 Glycosyl transferase, family 2 AW03_032620 ENOG4107QRS glycosyltransferase group 2 family protein AW03_032630 ENOG41068W6 Capsular polysaccharide biosynthesis protein AW03_032640 ENOG4108KMV Glycosyl transferase (Group 1 AW03_032650 ENOG4105K64 Glycosyl transferase, family 2 AW03_032660 ENOG4108PQP glycosyl transferase group 1 AW03_032680 ENOG4108QV3 biosynthesis protein AW03_032690 ENOG4105HTX biosynthesis protein AW03_032710 ENOG4105EBR Carboxylesterase AW03_032730 ENOG4105PY6 Phenolic acid decarboxylase AW03_032740 ENOG4105NI3 Protein of unknown function (DUF3237) AW03_032770 ENOG4105FQP Beta-lactamase AW03_032790 ENOG4105EDQ levansucrase EC 2.4.1.10 AW03_032800 ENOG4108HKT sucrose-6-phosphate hydrolase AW03_032810 ENOG4107QTZ amino acid AW03_032910 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AW03_032920 ENOG4107URF beta-phospho-glucomutase AW03_032930 ENOG4105CG3 alpha amylase, catalytic region AW03_032960 ENOG4105EG2 ABC transporter, permease AW03_032970 ENOG4105D56 permease protein AW03_032980 ENOG4107FKK extracellular solute-binding protein family 1 AW03_032990 ENOG4108IUK alpha amylase, catalytic AW03_033000 ENOG4105FKQ transcriptional regulator AW03_033010 ENOG4108URH decarboxylase AW03_033020 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain AW03_033030 ENOG4105CHH sulfate transporter AW03_033040 ENOG4108V2W Carbonate dehydratase AW03_033050 ENOG4105C5I Dehydrogenase AW03_033070 ENOG4105C19 ABC transporter AW03_033080 ENOG4105EWM Histidine kinase AW03_033100 ENOG4107A6P AW03_033110 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AW03_033120 ENOG4105KRI phosphocarrier protein (HPr AW03_033130 ENOG4105CIE May be required for sporulation (By similarity) AW03_033140 ENOG4105CHW UPF0052 protein AW03_033150 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) AW03_033160 ENOG4108Z4K mutator MutT protein AW03_033170 ENOG4105C3M thioredoxin reductase AW03_033200 ENOG4105BZ1 (ABC) transporter AW03_033230 ENOG4106FGC AW03_033250 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AW03_033260 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) AW03_033270 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase AW03_033280 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AW03_033290 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AW03_033300 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AW03_033310 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) AW03_033320 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) AW03_033340 ENOG4108E16 pectate lyase AW03_033350 ENOG4108S4C acetyltransferase AW03_033360 ENOG4107XGZ Hydrolase AW03_033370 ENOG4105HKU nucleoside recognition domain-containing protein AW03_033380 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) AW03_033390 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) AW03_033400 ENOG4105CE4 GlcNAc 6-P deacetylase AW03_033410 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) AW03_033420 ENOG4105FDP GntR family transcriptional regulator AW03_033430 ENOG41088CQ domain protein AW03_033440 ENOG41086DT Membrane protein of unknown function AW03_033450 ENOG41067S9 phage shock protein C, PspC AW03_033460 ENOG4108PY7 AW03_033490 ENOG4105I03 Flagellin AW03_033500 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AW03_033510 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) AW03_033540 ENOG4105MKU Transcriptional regulator AW03_033580 ENOG4105CN1 protease AW03_033590 ENOG4105CRP Part of the ABC transporter FtsEX involved in AW03_033600 ENOG4105CAK Cell division ATP-binding protein ftsE AW03_033630 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) AW03_033650 ENOG4105MS2 ribosomal subunit Interface protein AW03_033680 ENOG4105MQ3 flagellar protein FliS AW03_033690 ENOG4107RT6 flagellar hook-associated AW03_033700 ENOG41083S7 flagellar protein FlaG AW03_033710 ENOG4105I03 Flagellin AW03_033720 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) AW03_033730 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) AW03_033740 ENOG4105MKD AW03_033750 ENOG4105DTJ flagellar hook-associated protein AW03_033760 ENOG4105E1Q flagellar hook-associated protein AW03_033790 ENOG4105RU3 AW03_033800 ENOG41081UC Inherit from COG: Competence protein AW03_033840 ENOG4105WH1 Two component transcriptional regulator luxr family AW03_033850 ENOG4105BZU Histidine kinase AW03_033860 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AW03_033870 ENOG4108KGH TRANSCRIPTIONal AW03_033880 ENOG4105ESV Glycosyl transferase, family 4 AW03_033890 ENOG4107EF8 Glycosyl transferase (Group 1 AW03_033920 ENOG4105QZI O-Antigen Polymerase AW03_033930 ENOG4105C6Y Udp-glucose 6-dehydrogenase AW03_033940 ENOG4107RA4 Glycosyl transferase (Group 1 AW03_033950 ENOG4105PSV Polysaccharide Biosynthesis Protein AW03_033960 ENOG4105D3Q Sugar transferase AW03_033980 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AW03_033990 ENOG4105JFG SpoIID LytB domain protein AW03_034020 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AW03_034060 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AW03_034070 ENOG4105EY8 ABC transporter AW03_034120 ENOG41088M2 Glycosyl transferase family 2 AW03_034220 ENOG4105DG6 mannose-6-phosphate isomerase AW03_034250 ENOG4108NHD germination protein AW03_034260 ENOG4105C54 Major Facilitator superfamily AW03_034270 ENOG4108KGH TRANSCRIPTIONal AW03_034280 ENOG4105J7I hydrolase AW03_034290 ENOG4105K4H Nlp p60 protein AW03_034310 ENOG4105PNM synthesis protein AW03_034330 ENOG4105N98 Capsule biosynthesis protein capB AW03_034340 ENOG4105ETE Transcriptional regulator (LacI family AW03_034350 ENOG4108RVA ribokinase AW03_034360 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) AW03_034370 ENOG4105C2J ABC transporter AW03_034380 ENOG4105CNN ABC, transporter AW03_034390 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AW03_034430 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein AW03_034440 ENOG4107FQX Alpha-acetolactate decarboxylase AW03_034460 ENOG4107RSM transcriptional regulator AW03_034490 ENOG4106UIA AW03_034520 ENOG4107XC4 flavin reductase domain protein, FMN-binding AW03_034540 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AW03_034560 ENOG4105CAH Chromate AW03_034570 ENOG4105FGV Chromate AW03_034580 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) AW03_034660 ENOG4108XI2 Domain of unknown function (DUF1963) AW03_034670 ENOG4105C6Y Udp-glucose 6-dehydrogenase AW03_034680 ENOG4108RB3 Capsular polysaccharide biosynthesis protein AW03_034690 ENOG4107YJ4 chain length determinant protein AW03_034700 ENOG4105HTX biosynthesis protein AW03_034720 ENOG4105KBK Zinc finger, swim domain protein AW03_034730 ENOG4105C0D helicase AW03_034740 ENOG410667J hydrolase AW03_034750 ENOG4105E98 transcriptional regulator DeoR family AW03_034760 ENOG4105Z8H single-stranded DNA-binding protein AW03_034810 ENOG4108VAC response regulator AW03_034830 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) AW03_034840 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) AW03_034860 ENOG4105CGA flagellar basal-body rod protein FlgG AW03_034880 ENOG4105DFF Rod shape-determining protein mreb AW03_034890 ENOG4105MT0 Sporulation transcriptional regulator spoiiid AW03_034900 ENOG4107MII Sugar-specific transcriptional regulator TrmB AW03_034910 ENOG4105CZM Major Facilitator AW03_034920 ENOG4108M26 parallel beta-helix repeat protein AW03_034930 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease AW03_034940 ENOG41080V3 Major Facilitator superfamily AW03_034950 ENOG4105D3W isochorismatase AW03_034960 ENOG4107P26 AW03_034970 ENOG4105BZU Histidine kinase AW03_034990 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AW03_035010 ENOG4105FRN stage II sporulation protein AW03_035020 ENOG4107TCE N-acetyltransferase AW03_035060 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AW03_035070 ENOG4107TXC Transcriptional regulator AW03_035080 ENOG4106BRK AW03_035090 ENOG4108RYK Nad-dependent epimerase dehydratase AW03_035100 ENOG4108Z40 Transcriptional regulator AW03_035110 ENOG4105CQM Urea amidohydrolase subunit alpha AW03_035120 ENOG4105KI2 Urea amidohydrolase subunit beta AW03_035130 ENOG4108YZ9 Urea amidohydrolase subunit gamma AW03_035190 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) AW03_035210 ENOG4108TF4 von Willebrand factor, type A AW03_035230 ENOG4105JFG SpoIID LytB domain protein AW03_035240 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AW03_035260 ENOG4106778 Protein of unknown function (DUF1146) AW03_035280 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) AW03_035290 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) AW03_035300 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) AW03_035310 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) AW03_035350 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) AW03_035370 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) AW03_035380 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) AW03_035390 ENOG4108UIC UPF0340 protein AW03_035400 ENOG4108YZG isomerase AW03_035410 ENOG4107WAU Protein tyrosine phosphatase AW03_035420 ENOG410815N Probably functions as a manganese efflux pump (By similarity) AW03_035430 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AW03_035450 ENOG4108ZXQ stage ii sporulation protein r AW03_035480 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AW03_035490 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) AW03_035500 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AW03_035520 ENOG4107TT2 Auxin Efflux Carrier AW03_035530 ENOG4105C6K Malic enzyme AW03_035540 ENOG4107104 thymidine kinase AW03_035550 ENOG41082DI 50s ribosomal protein l31 AW03_035560 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) AW03_035570 ENOG4105CBT Fructose-1,6-bisphosphatase AW03_035580 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) AW03_035590 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway AW03_035600 ENOG4105D2N Aldolase AW03_035610 ENOG410812K response regulator receiver protein AW03_035630 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) AW03_035650 ENOG4105C1G acyl-Coa dehydrogenase AW03_035660 ENOG4105DF6 Fe-S oxidoreductase AW03_035680 ENOG4105E5J UV damage endonuclease AW03_035700 ENOG4105NAE bifunctional deaminase-reductase domain protein AW03_035710 ENOG4105BZ1 (ABC) transporter AW03_035720 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) AW03_035740 ENOG4105R3A Nitrate reductase AW03_035750 ENOG4108IUE nitrate reductase beta subunit AW03_035790 ENOG4107V6Q Cyclic nucleotide-binding domain AW03_035810 ENOG4105C75 arginyL-tRNA synthetase AW03_035820 ENOG410684U Domain of unknown function (DUF1934) AW03_035840 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E AW03_035930 ENOG4107JM4 Tetratricopeptide repeat AW03_035990 ENOG4108RDQ ABC transporter AW03_036010 ENOG4105CYW agmatinase AW03_036020 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) AW03_036030 ENOG4105BZ4 penicillin-binding protein AW03_036040 ENOG4108XFG YwhD family AW03_036050 ENOG4108Z4T Peptidase M50 AW03_036060 ENOG41069HH 4-oxalocrotonate tautomerase AW03_036070 ENOG41067TZ transcriptional regulator, MarR family AW03_036080 ENOG4105C22 threonyL-tRNA synthetase AW03_036100 ENOG4105C57 major facilitator superfamily AW03_036110 ENOG41062ES Transcriptional regulator AW03_036130 ENOG4105DCI Phosphohydrolase AW03_036150 ENOG4108VCI transcription factor, rsfa family AW03_036160 ENOG4108RNG Permease of the drug metabolite transporter AW03_036170 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) AW03_036180 ENOG4105DUM transcriptional regulator, lysR family AW03_036190 ENOG4108IJ2 phosphate acetyltransferase AW03_036220 ENOG4105CHM Aminotransferase AW03_036240 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase AW03_036250 ENOG4105CHR reductase AW03_036260 ENOG4106CHD Bacilysin biosynthesis protein bacB AW03_036270 ENOG41061WN bacilysin biosynthesis protein AW03_036280 ENOG4105FCW Major Facilitator superfamily AW03_036310 ENOG4105C26 Dehydrogenase AW03_036320 ENOG4105D82 Glutamate dehydrogenase AW03_036340 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase AW03_036350 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AW03_036360 ENOG4105C1B dTDP-glucose 4-6-dehydratase AW03_036370 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AW03_036380 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG AW03_036390 ENOG4107TY6 Acylneuraminate cytidylyltransferase AW03_036410 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD AW03_036420 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AW03_036490 ENOG4105C26 Dehydrogenase AW03_036500 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) AW03_036510 ENOG4108RJ9 Glycosyl transferase, family 2 AW03_036520 ENOG4105DWF phosphomethylpyrimidine kinase AW03_036550 ENOG4105C5Y PTS System AW03_036560 ENOG4108QTI )-transporter AW03_036590 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin AW03_036600 ENOG4105DEN Luciferase family AW03_036610 ENOG4108DBC nitroreductase AW03_036640 ENOG41060D1 Quinol oxidase AW03_036650 ENOG4105CCU oxidase (Subunit III) AW03_036660 ENOG4105BZ9 Cytochrome C oxidase, subunit I AW03_036670 ENOG4105E2S oxidase) subunit II AW03_036680 ENOG4107BMA Transglycosylase associated protein AW03_036700 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) AW03_036710 ENOG4105WH5 Teichoic acid glycosylation protein AW03_036760 ENOG4107ZXU DSBA oxidoreductase AW03_036770 ENOG4105DBE peroxidase AW03_036780 ENOG410650H (LipO)protein AW03_036790 ENOG4107SJW iron permease, FTR1 AW03_036800 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) AW03_036820 ENOG4105CMU LysR family (Transcriptional regulator AW03_036830 ENOG4105VAW lrga family AW03_036840 ENOG41067MG lrgb family AW03_036850 ENOG4105D8G Major Facilitator superfamily AW03_036870 ENOG4105DR4 Methyltransferase AW03_036900 ENOG4108YV3 Protein of unknown function (DUF2711) AW03_036910 ENOG4105CK1 PTS System AW03_036920 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin AW03_036950 ENOG4105X1N Glycosyl transferase family 8 AW03_036970 ENOG4105GVJ transcriptional regulator AW03_036980 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) AW03_036990 ENOG4105IIU Aminopeptidase AW03_037010 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AW03_037030 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) AW03_037040 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein AW03_037060 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD AW03_037070 ENOG4108VHC Short-chain dehydrogenase reductase Sdr AW03_037080 ENOG4105CM2 brancheD-chain amino acid aminotransferase AW03_037090 ENOG4105F8D glycoside hydrolase family 4 AW03_037100 ENOG4105VCP PTS System AW03_037110 ENOG4105CK1 PTS System AW03_037120 ENOG4105VZJ PTS System AW03_037130 ENOG4105EMD TRANSCRIPTIONal AW03_037150 ENOG4108VX5 3-methyladenine DNA glycosylase AW03_037160 ENOG4105CH6 catalase AW03_037190 ENOG4105DA5 (ABC) transporter AW03_037200 ENOG41069JR AW03_037240 ENOG4105ETS cytosine purines uracil thiamine allantoin AW03_037250 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AW03_037260 ENOG4108JJ8 (ABC) transporter AW03_037270 ENOG4108JJ9 ABC, transporter AW03_037280 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AW03_037290 ENOG4105C4M (Ubiquinol oxidase) subunit I AW03_037300 ENOG4105D2K citrate carrier protein AW03_037330 ENOG4107BJW polysaccharide deacetylase AW03_037370 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) AW03_037390 ENOG4105CMR udp-glucose 4-epimerase AW03_037400 ENOG4105KIS phospholipid-binding protein AW03_037410 ENOG4108WAV Transcriptional regulator AW03_037430 ENOG4105BZU Histidine kinase AW03_037440 ENOG4105WH1 Two component transcriptional regulator luxr family AW03_037450 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) AW03_037510 ENOG4105DTD Dehydrogenase AW03_037520 ENOG4108IIH CoA-transferase subunit B AW03_037530 ENOG4105D6N CoA-transferase, subunit a AW03_037540 ENOG4105CY2 Citrate transporter AW03_037550 ENOG4105DHI Methyltransferase AW03_037590 ENOG4105CH6 catalase AW03_037600 ENOG4105D4T Citrate transporter AW03_037610 ENOG4108RZ2 Glycoside hydrolase family 16 AW03_037620 ENOG4105CID antiterminator AW03_037640 ENOG4105DEU major facilitator superfamily AW03_037650 ENOG4105C1J atp-dependent rna helicase AW03_037660 ENOG4107TDE lipolytic protein G-D-S-L family AW03_037710 ENOG4107YZX Universal stress protein AW03_037720 ENOG4105CS2 ec 3.2.1.21 AW03_037730 ENOG4105C5Y PTS System AW03_037810 ENOG4107EV6 Inherit from COG: YD repeat protein AW03_037840 ENOG4108F3G Type I restriction-modification system, R subunit AW03_037860 ENOG4105M6F mutator MutT protein AW03_037870 ENOG4106Z5D Glycoside Hydrolase Family 43 AW03_037890 ENOG4105C84 Histidine ammonia-lyase AW03_037900 ENOG4105CGP Urocanate hydratase AW03_037910 ENOG4105CI2 imidazolone-5-propionate hydrolase AW03_037920 ENOG4107W25 arginase agmatinase formiminoglutamase AW03_037940 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) AW03_037950 ENOG4105D9N nucleoside AW03_037970 ENOG4107RHR regulatoR AW03_037980 ENOG4108TM9 integral membrane protein AW03_037990 ENOG4105ENY Ethanolamine utilization protein eutH AW03_038000 ENOG4108PGP mmge prpd family protein AW03_038010 ENOG4105CH2 amidohydrolase AW03_038030 ENOG4108HW4 amino acid AbC transporter AW03_038040 ENOG4105EAB amino acid AbC transporter AW03_038050 ENOG4108XSB acetyltransferase, (GNAT) family AW03_038060 ENOG4105CPU Monooxygenase AW03_038070 ENOG4107QHE Choloylglycine hydrolase AW03_038080 ENOG410667J hydrolase AW03_038140 ENOG4108V5C ABC transporter AW03_038200 ENOG4105D2N Aldolase AW03_038210 ENOG4107TRN Xylose isomerase domain protein TIM barrel AW03_038220 ENOG4105F0H myo-inositol catabolism protein AW03_038230 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) AW03_038250 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) AW03_038260 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) AW03_038270 ENOG4105D7K pfkb domain protein AW03_038290 ENOG4105C26 Dehydrogenase AW03_038310 ENOG4105CPC Aldo Keto reductase AW03_038340 ENOG4107QNK )-transporter AW03_038350 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AW03_038370 ENOG41061TZ Short-chain dehydrogenase reductase Sdr AW03_038380 ENOG4105ST3 Transcriptional regulator AW03_038390 ENOG4105C26 Dehydrogenase AW03_038400 ENOG41085PJ rdd domain containing protein AW03_038410 ENOG4108ITS PQQ enzyme repeat AW03_038430 ENOG41085PJ rdd domain containing protein AW03_038460 ENOG4105J7D transcriptional regulator AW03_038470 ENOG4107JEE Short-chain dehydrogenase reductase Sdr AW03_038480 ENOG41061AU MarR family Transcriptional regulator AW03_038500 ENOG41067MG lrgb family AW03_038520 ENOG4105BZW Glycerate kinase AW03_038530 ENOG4105G3Z GntR family transcriptional regulator AW03_038540 ENOG4105CMG Carbohydrate kinase AW03_038550 ENOG4105C6Z Gluconate AW03_038560 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AW03_038570 ENOG4105D3R alkyl hydroperoxide reductase AW03_038580 ENOG4108JU3 Alkyl hydroperoxide reductase AW03_038600 ENOG4105CS2 ec 3.2.1.21 AW03_038620 ENOG4108S3Y transcriptional regulator AW03_038640 ENOG4106KKU AW03_038650 ENOG4108Z15 abc transporter atp-binding protein AW03_038660 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 AW03_038680 ENOG4107QMH DNA methylase AW03_038710 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) AW03_038740 ENOG4105E2A Dehydrogenase AW03_038780 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) AW03_038790 ENOG4105WQG acetyltransferase AW03_038800 ENOG410780I phosphoprotein phosphatase activity AW03_038820 ENOG41066UZ arginase EC 3.5.3.1 AW03_038830 ENOG4108IQI permease AW03_038840 ENOG4105C8Y Acetylornithine aminotransferase AW03_038850 ENOG4108JUB Transcriptional regulator AW03_038860 ENOG4105C0H protease AW03_038870 ENOG4105Q2H domain protein AW03_038900 ENOG4105BZU Histidine kinase AW03_038910 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AW03_038920 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis AW03_038930 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase AW03_038940 ENOG4105CDU Replicative dna helicase AW03_038980 ENOG4105DJ2 Major Facilitator Superfamily AW03_038990 ENOG4105EDW glycosyl transferase, family 39 AW03_039000 ENOG4105K9Q Binds to the 23S rRNA (By similarity) AW03_039010 ENOG4105BZR domain protein AW03_039020 ENOG4108XMW Membrane AW03_039050 ENOG4105KVH Transcriptional regulator AW03_039060 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase AW03_039100 ENOG41090E6 transcriptional regulator MERR family AW03_039120 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein AW03_039130 ENOG4105DDN Pentapeptide repeat-containing protein AW03_039140 ENOG4105D94 Major Facilitator Superfamily AW03_039150 ENOG4107RSM transcriptional regulator AW03_039160 ENOG41082BV acetyltransferase AW03_039170 ENOG41081I9 integral membrane protein AW03_039180 ENOG4107V2S Transcriptional regulator AW03_039190 ENOG4108VP3 Lysine exporter protein (LysE YggA) AW03_039220 ENOG4108U05 Transcriptional regulator AW03_039230 ENOG41082BV acetyltransferase AW03_039250 ENOG4108U7W acetyltransferase AW03_039260 ENOG4105UNS Pfam:DUF419 AW03_039270 ENOG4105NAE bifunctional deaminase-reductase domain protein AW03_039300 ENOG4108UXE Protein tyrosine phosphatase AW03_039310 ENOG4105D6J arsenicaL-resistance protein AW03_039320 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase AW03_039330 ENOG41085FC arsR family transcriptional regulator AW03_039350 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AW03_039360 ENOG4105C7Z Conserved Protein AW03_039370 ENOG4107YVC modification (methylase) AW03_039390 ENOG4105C7Z Conserved Protein AW03_039400 ENOG4107FCW Abortive infection protein AW03_039420 ENOG4108UW5 maltose o-acetyltransferase AW03_039430 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase AW03_039450 ENOG4105CGK Exodeoxyribonuclease III AW03_039460 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AW03_039470 ENOG4108UUM single-stranded DNA-binding protein AW03_039480 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) AW03_039490 ENOG4105C3G gtp-binding protein AW03_039500 ENOG4108J2R molybdopterin oxidoreductase AW03_039510 ENOG4105VDK protein, conserved in bacteria AW03_039530 ENOG4108ZDA Sporulation protein YyaC AW03_039540 ENOG4105FA0 parb-like partition protein AW03_039550 ENOG4107QJE Chromosome Partitioning Protein AW03_039580 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) AW03_039590 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) AW03_039600 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) AW03_039630 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)