locus-tag	class	description
D0819_00090	COG4326	sporulation control protein
D0819_00100	COG5577	PFAM Coat F domain
D0819_00105	COG3340	Belongs to the peptidase S51 family
D0819_00110	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
D0819_00125	COG0753	catalase activity
D0819_00130	COG1116	anion transmembrane transporter activity
D0819_00135	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D0819_00140	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0819_00145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0819_00155	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D0819_00165	COG1476	TRANSCRIPTIONal
D0819_00175	COG3382	B3 4 domain protein
D0819_00180	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D0819_00190	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D0819_00195	COG0789	Transcriptional regulator
D0819_00200	COG1664	Polymer-forming cytoskeletal
D0819_00205	COG1664	Polymer-forming cytoskeletal
D0819_00210	COG2766	serine protein kinase
D0819_00215	COG2718	Belongs to the UPF0229 family
D0819_00220	COG1846	Transcriptional regulator
D0819_00225	COG1566	PFAM secretion protein HlyD family protein
D0819_00230	COG2814	Major facilitator Superfamily
D0819_00235	COG0655	NAD(P)H dehydrogenase (quinone) activity
D0819_00255	COG1725	Transcriptional regulator
D0819_00260	COG1131	(ABC) transporter
D0819_00265	COG1131	(ABC) transporter
D0819_00270	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D0819_00275	COG1278	Cold shock
D0819_00285	COG1464	Belongs to the NlpA lipoprotein family
D0819_00290	COG3706	GGDEF domain
D0819_00295	COG1823	symporter activity
D0819_00325	COG5577	PFAM Coat F domain
D0819_00330	COG4085	toxin activity
D0819_00330	COG1525	nuclease
D0819_00330	COG0737	Belongs to the 5'-nucleotidase family
D0819_00335	COG3764	Sortase (surface protein transpeptidase)
D0819_00340	COG0564	pseudouridine synthase activity
D0819_00350	COG0517	IMP dehydrogenase activity
D0819_00355	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0819_00360	COG3153	acetyltransferase
D0819_00360	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D0819_00365	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D0819_00370	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
D0819_00375	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
D0819_00380	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
D0819_00385	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
D0819_00390	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D0819_00395	COG2203	Gaf domain
D0819_00395	COG4585	Histidine kinase
D0819_00400	COG2197	response regulator
D0819_00405	COG0431	NADPH-dependent FMN reductase
D0819_00420	COG1388	LysM domain
D0819_00420	COG0791	NLP P60 protein
D0819_00425	COG1959	2 iron, 2 sulfur cluster binding
D0819_00430	COG0668	transmembrane transport
D0819_00435	COG2719	SpoVR family
D0819_00440	COG1785	Belongs to the alkaline phosphatase family
D0819_00445	COG1388	LysM domain
D0819_00445	COG0791	NLP P60 protein
D0819_00450	COG0583	DNA-binding transcription factor activity
D0819_00455	COG0372	Belongs to the citrate synthase family
D0819_00460	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_00465	COG0531	amino acid
D0819_00470	COG0733	neurotransmitter:sodium symporter activity
D0819_00475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0819_00480	COG0456	acetyltransferase
D0819_00495	COG1595	DNA-templated transcription, initiation
D0819_00500	COG0667	Aldo Keto reductase
D0819_00505	COG0204	Acyl-transferase
D0819_00510	COG1253	flavin adenine dinucleotide binding
D0819_00515	COG0789	Transcriptional regulator
D0819_00520	COG0436	Aminotransferase
D0819_00525	COG1253	flavin adenine dinucleotide binding
D0819_00530	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D0819_00535	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
D0819_00540	COG0584	glycerophosphoryl diester phosphodiesterase
D0819_00550	COG0668	transmembrane transport
D0819_00555	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D0819_00560	COG0726	polysaccharide deacetylase
D0819_00565	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D0819_00570	COG1757	Na H antiporter
D0819_00575	COG0589	response to stress
D0819_00585	COG1132	(ABC) transporter
D0819_00590	COG1132	(ABC) transporter
D0819_00595	COG0702	epimerase
D0819_00615	COG0189	ligase activity
D0819_00620	COG0189	ligase activity
D0819_00625	COG4399	Belongs to the UPF0754 family
D0819_00630	COG3679	Belongs to the UPF0342 family
D0819_00635	COG4335	DNA alkylation repair
D0819_00640	COG0561	phosphatase activity
D0819_00645	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D0819_00650	COG0475	glutathione-regulated potassium exporter activity
D0819_00655	COG0490	domain, Protein
D0819_00665	COG1024	Enoyl-CoA hydratase
D0819_00675	COG4152	abc transporter atp-binding protein
D0819_00680	COG1668	transmembrane transport
D0819_00690	COG0420	3'-5' exonuclease activity
D0819_00695	COG4717	serine-type aminopeptidase activity
D0819_00700	COG3481	metal-dependent phosphohydrolase, HD sub domain
D0819_00710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0819_00740	COG1846	Transcriptional regulator
D0819_00745	COG4980	gas vesicle protein
D0819_00760	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D0819_00765	COG0537	adenosine 5'-monophosphoramidase activity
D0819_00770	COG1131	(ABC) transporter
D0819_00775	COG4473	ABC transporter
D0819_00785	COG1473	amidohydrolase
D0819_00790	COG3069	C4-dicarboxylate transmembrane transporter activity
D0819_00800	COG2329	Antibiotic biosynthesis monooxygenase
D0819_00805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0819_00810	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
D0819_00825	COG1309	transcriptional regulator
D0819_00830	COG1511	domain protein
D0819_00835	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D0819_00840	COG4377	Putative membrane peptidase family (DUF2324)
D0819_00850	COG1363	Peptidase, m42
D0819_00855	COG4405	Protein conserved in bacteria
D0819_00860	COG1301	dicarboxylic acid transport
D0819_00870	COG1234	tRNA 3'-trailer cleavage
D0819_00875	COG0095	Lipoate-protein ligase
D0819_00880	COG0702	epimerase
D0819_00885	COG0318	PFAM AMP-dependent synthetase and ligase
D0819_00895	COG0501	Belongs to the peptidase M48B family
D0819_00910	COG0604	alcohol dehydrogenase
D0819_00915	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D0819_00920	COG0406	alpha-ribazole phosphatase activity
D0819_00925	COG0183	Belongs to the thiolase family
D0819_00930	COG0318	PFAM AMP-dependent synthetase and ligase
D0819_00935	COG1268	BioY protein
D0819_00940	COG0840	transmembrane signaling receptor activity
D0819_00945	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0819_00945	COG0723	plastoquinol--plastocyanin reductase activity
D0819_00950	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_00960	COG4903	ComK protein
D0819_00965	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_00975	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0819_00990	COG0398	Pfam SNARE associated Golgi protein
D0819_00995	COG0681	Belongs to the peptidase S26 family
D0819_01000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0819_01005	COG1846	Transcriptional regulator
D0819_01010	COG0738	Major facilitator superfamily
D0819_01015	COG0673	inositol 2-dehydrogenase activity
D0819_01020	COG0561	phosphatase activity
D0819_01025	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D0819_01030	COG1609	Transcriptional regulator
D0819_01035	COG3180	Ammonia monooxygenase
D0819_01040	COG0477	Major facilitator Superfamily
D0819_01040	COG2814	Major facilitator Superfamily
D0819_01045	COG4533	DNA binding
D0819_01055	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
D0819_01060	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
D0819_01065	COG1074	ATP-dependent DNA helicase activity
D0819_01070	COG0420	3'-5' exonuclease activity
D0819_01075	COG0419	ATPase involved in DNA repair
D0819_01080	COG1403	HNH endonuclease
D0819_01120	COG5337	Spore coat protein CotH
D0819_01125	COG0179	Fumarylacetoacetate (FAA) hydrolase
D0819_01145	COG0367	asparagine synthase
D0819_01150	COG2318	DinB family
D0819_01155	COG1562	ergosterol biosynthetic process
D0819_01160	COG0534	Mate efflux family protein
D0819_01165	COG1917	Cupin 2, conserved barrel domain protein
D0819_01165	COG2207	Transcriptional regulator
D0819_01170	COG1609	Transcriptional regulator
D0819_01175	COG0673	inositol 2-dehydrogenase activity
D0819_01180	COG2318	DinB family
D0819_01185	COG1279	arginine transmembrane transporter activity
D0819_01190	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0819_01195	COG1357	PFAM Pentapeptide repeats (8 copies)
D0819_01200	COG2267	carboxylic ester hydrolase activity
D0819_01205	COG0529	Catalyzes the synthesis of activated sulfate
D0819_01210	COG2046	Belongs to the sulfate adenylyltransferase family
D0819_01215	COG0175	sulfate reduction
D0819_01220	COG2045	Belongs to the ComB family
D0819_01225	COG1809	phosphosulfolactate synthase activity
D0819_01230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D0819_01235	COG4948	Mandelate Racemase Muconate Lactonizing
D0819_01240	COG2814	Major facilitator Superfamily
D0819_01245	COG0454	-acetyltransferase
D0819_01250	COG2153	protein acetylation
D0819_01255	COG0646	methionine synthase
D0819_01255	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D0819_01260	COG1666	GTP binding
D0819_01265	COG2996	Protein conserved in bacteria
D0819_01285	COG1695	Transcriptional regulator
D0819_01300	COG3227	Zinc metalloprotease (Elastase)
D0819_01305	COG1307	EDD domain protein, DegV family
D0819_01310	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D0819_01325	COG0561	phosphatase activity
D0819_01330	COG1073	alpha beta
D0819_01335	COG2151	metal-sulfur cluster biosynthetic enzyme
D0819_01345	COG0277	FAD linked oxidase domain protein
D0819_01350	COG2271	Major facilitator Superfamily
D0819_01355	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
D0819_01370	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D0819_01375	COG0505	Belongs to the CarA family
D0819_01380	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D0819_01385	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D0819_01400	COG2267	carboxylic ester hydrolase activity
D0819_01410	COG1744	ABC transporter substrate-binding protein PnrA-like
D0819_01425	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D0819_01430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0819_01435	COG5504	Zn-dependent protease
D0819_01440	COG0444	Belongs to the ABC transporter superfamily
D0819_01445	COG4608	Belongs to the ABC transporter superfamily
D0819_01455	COG0601	transmembrane transport
D0819_01460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0819_01470	COG0180	Tryptophanyl-tRNA synthetase
D0819_01475	COG4166	transmembrane transport
D0819_01480	COG0601	transmembrane transport
D0819_01485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0819_01490	COG0444	Belongs to the ABC transporter superfamily
D0819_01495	COG4608	Belongs to the ABC transporter superfamily
D0819_01500	COG2814	Major facilitator Superfamily
D0819_01505	COG0456	acetyltransferase
D0819_01510	COG1393	Belongs to the ArsC family
D0819_01515	COG0861	Integral membrane protein TerC family
D0819_01520	COG4862	establishment of competence for transformation
D0819_01525	COG4469	Competence protein
D0819_01530	COG1164	Oligoendopeptidase f
D0819_01550	COG2346	COG2346, Truncated hemoglobins
D0819_01555	COG0741	lytic transglycosylase activity
D0819_01560	COG4116	CYTH
D0819_01570	COG2357	RelA SpoT domain protein
D0819_01575	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D0819_01580	COG0564	pseudouridine synthase activity
D0819_01585	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D0819_01590	COG0569	domain protein
D0819_01590	COG0475	glutathione-regulated potassium exporter activity
D0819_01595	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D0819_01600	COG0352	thiamine-phosphate diphosphorylase activity
D0819_01605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0819_01610	COG2104	thiamine diphosphate biosynthetic process
D0819_01615	COG2022	thiamine diphosphate biosynthetic process
D0819_01620	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D0819_01625	COG0351	phosphomethylpyrimidine kinase
D0819_01630	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D0819_01685	COG0210	DNA helicase
D0819_01695	COG2153	protein acetylation
D0819_01700	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D0819_01705	COG2382	esterase
D0819_01710	COG0626	cystathionine gamma-synthase activity
D0819_01715	COG0626	cystathionine gamma-synthase activity
D0819_01720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0819_01785	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D0819_01790	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_01805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0819_01805	COG3711	transcriptional antiterminator
D0819_01810	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0819_01810	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0819_01810	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0819_01815	COG1482	cell wall glycoprotein biosynthetic process
D0819_01825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0819_01835	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
D0819_01855	COG0109	protoheme IX farnesyltransferase activity
D0819_01865	COG0726	polysaccharide deacetylase
D0819_01885	COG2205	protein histidine kinase activity
D0819_01895	COG3383	formate dehydrogenase (NAD+) activity
D0819_01900	COG2427	Protein of unknown function (DUF1641)
D0819_01910	COG1051	belongs to the nudix hydrolase family
D0819_01920	COG2124	cytochrome p450
D0819_01925	COG1819	glycosyl
D0819_01935	COG1587	Uroporphyrinogen-III synthase
D0819_01940	COG0390	transport system, permease component
D0819_01945	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D0819_01950	COG0697	spore germination
D0819_01955	COG4297	protein containing double-stranded beta helix domain
D0819_01965	COG1252	NADH dehydrogenase
D0819_01970	COG1904	glucuronate isomerase
D0819_01975	COG2211	Major facilitator Superfamily
D0819_01980	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
D0819_01985	COG1063	alcohol dehydrogenase
D0819_01990	COG1312	Catalyzes the dehydration of D-mannonate
D0819_01995	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_02000	COG2271	Major facilitator Superfamily
D0819_02005	COG1609	Transcriptional regulator
D0819_02010	COG0246	Mannitol dehydrogenase
D0819_02015	COG2721	sulfolactate sulfo-lyase activity
D0819_02020	COG0730	response to heat
D0819_02025	COG2318	DinB family
D0819_02030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D0819_02035	COG0457	Tetratricopeptide repeat
D0819_02045	COG2350	Protein conserved in bacteria
D0819_02050	COG1388	LysM domain
D0819_02050	COG3409	Peptidoglycan-binding domain 1 protein
D0819_02050	COG5632	N-Acetylmuramoyl-L-alanine amidase
D0819_02060	COG4195	phage-related replication protein
D0819_02065	COG3546	catalase activity
D0819_02070	COG2856	Zn peptidase
D0819_02075	COG1396	sequence-specific DNA binding
D0819_02085	COG1522	sequence-specific DNA binding
D0819_02090	COG1484	DNA-dependent DNA replication
D0819_02110	COG1595	DNA-templated transcription, initiation
D0819_02115	COG3728	DNA packaging
D0819_02115	COG5484	DNA packaging
D0819_02120	COG1783	phage Terminase large subunit
D0819_02125	COG5518	Phage portal protein
D0819_02130	COG0338	D12 class N6 adenine-specific DNA methyltransferase
D0819_02135	COG4653	Phage capsid family
D0819_02185	COG3953	SLT domain
D0819_02185	COG5412	phage tail tape measure protein
D0819_02190	COG1652	LysM domain
D0819_02195	COG4193	domain, Protein
D0819_02205	COG3628	GPW Gp25 family protein
D0819_02210	COG3299	homolog of phage Mu protein gp47
D0819_02215	COG3778	Protein conserved in bacteria
D0819_02255	COG3409	Peptidoglycan-binding domain 1 protein
D0819_02255	COG5632	N-Acetylmuramoyl-L-alanine amidase
D0819_02270	COG0306	phosphate transporter
D0819_02275	COG1392	Phosphate transport regulator
D0819_02280	COG0531	amino acid
D0819_02285	COG0346	lactoylglutathione lyase activity
D0819_02290	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D0819_02295	COG0463	Glycosyl transferase, family 2
D0819_02305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0819_02310	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D0819_02315	COG2362	D-Aminopeptidase
D0819_02320	COG0601	transmembrane transport
D0819_02325	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D0819_02330	COG0444	Belongs to the ABC transporter superfamily
D0819_02335	COG4166	transmembrane transport
D0819_02340	COG1619	proteins homologs of microcin C7 resistance protein MccF
D0819_02345	COG4948	Mandelate Racemase Muconate Lactonizing
D0819_02350	COG0791	NLP P60 protein
D0819_02355	COG4608	Belongs to the ABC transporter superfamily
D0819_02360	COG2706	6-phosphogluconolactonase activity
D0819_02365	COG1834	amidinotransferase
D0819_02370	COG1607	acyl-coa hydrolase
D0819_02375	COG1017	nitric oxide dioxygenase activity
D0819_02375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D0819_02385	COG2323	membrane
D0819_02390	COG2318	DinB family
D0819_02395	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0819_02400	COG2076	Multidrug Resistance protein
D0819_02405	COG2076	Multidrug Resistance protein
D0819_02410	COG0788	formyltetrahydrofolate deformylase activity
D0819_02415	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D0819_02420	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D0819_02425	COG1764	response to oxidative stress
D0819_02430	COG1846	Transcriptional regulator
D0819_02435	COG1764	response to oxidative stress
D0819_02440	COG0590	tRNA wobble adenosine to inosine editing
D0819_02445	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D0819_02450	COG1404	Belongs to the peptidase S8 family
D0819_02455	COG1366	Belongs to the anti-sigma-factor antagonist family
D0819_02460	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D0819_02465	COG1122	ATPase activity
D0819_02470	COG4721	ABC-type cobalt transport system, permease component
D0819_02480	COG0745	RESPONSE REGULATOR receiver
D0819_02485	COG3850	Histidine kinase
D0819_02485	COG5002	protein histidine kinase activity
D0819_02490	COG3212	peptidase
D0819_02495	COG3212	peptidase
D0819_02510	COG2239	Acts as a magnesium transporter
D0819_02515	COG0789	Transcriptional regulator
D0819_02530	COG1846	Transcriptional regulator
D0819_02535	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D0819_02540	COG0726	polysaccharide deacetylase
D0819_02545	COG1408	metallophosphoesterase
D0819_02555	COG0463	Glycosyl transferase, family 2
D0819_02560	COG1793	dna ligase
D0819_02560	COG3285	dna ligase
D0819_02565	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
D0819_02570	COG5001	Diguanylate cyclase
D0819_02570	COG3300	MHYT domain
D0819_02575	COG0586	Pfam SNARE associated Golgi protein
D0819_02580	COG0861	Integral membrane protein TerC family
D0819_02585	COG1191	sigma factor activity
D0819_02605	COG0501	Belongs to the peptidase M48B family
D0819_02610	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D0819_02625	COG3594	Acyltransferase
D0819_02630	COG5002	protein histidine kinase activity
D0819_02635	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D0819_02640	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
D0819_02645	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
D0819_02650	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
D0819_02655	COG0436	Aminotransferase
D0819_02660	COG1850	ribulose-bisphosphate carboxylase activity
D0819_02665	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
D0819_02670	COG0235	Class ii aldolase
D0819_02675	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
D0819_02680	COG3339	Conserved Protein
D0819_02695	COG3852	Histidine kinase
D0819_02700	COG1846	Transcriptional regulator
D0819_02705	COG1360	Flagellar Motor Protein
D0819_02710	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D0819_02720	COG0542	response to heat
D0819_02725	COG3949	Membrane
D0819_02730	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D0819_02735	COG0720	synthase
D0819_02740	COG0602	queuosine metabolic process
D0819_02745	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
D0819_02750	COG1733	regulation of RNA biosynthetic process
D0819_02755	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_02760	COG4641	Protein conserved in bacteria
D0819_02760	COG1388	LysM domain
D0819_02765	COG1388	LysM domain
D0819_02770	COG3858	chitin binding
D0819_02780	COG4873	Protein conserved in bacteria
D0819_02790	COG3773	Cell wall hydrolase
D0819_02795	COG2244	polysaccharide biosynthetic process
D0819_02800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0819_02805	COG2217	Heavy metal translocating P-type atpase
D0819_02815	COG0006	proline dipeptidase activity
D0819_02820	COG1609	Transcriptional regulator
D0819_02825	COG3711	transcriptional antiterminator
D0819_02830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0819_02830	COG2190	(PTS) system
D0819_02830	COG1263	PTS System
D0819_02835	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0819_02840	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D0819_02850	COG1533	DNA photolyase activity
D0819_02855	COG0456	acetyltransferase
D0819_02860	COG0840	transmembrane signaling receptor activity
D0819_02865	COG2084	Dehydrogenase
D0819_02870	COG4257	antibiotic catabolic process
D0819_02875	COG2340	Cysteine-rich secretory protein family
D0819_02880	COG0768	penicillin binding
D0819_02885	COG4191	Histidine kinase
D0819_02890	COG0436	Aminotransferase
D0819_02900	COG0835	chemotaxis
D0819_02900	COG0784	Response regulator, receiver
D0819_02910	COG2814	Major facilitator Superfamily
D0819_02915	COG1376	ErfK ybiS ycfS ynhG family protein
D0819_02920	COG1408	metallophosphoesterase
D0819_02925	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_02930	COG2200	EAL domain
D0819_02935	COG4703	Protein of unknown function (DUF1797)
D0819_02940	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
D0819_02950	COG0517	IMP dehydrogenase activity
D0819_02955	COG0583	DNA-binding transcription factor activity
D0819_02960	COG0716	FMN binding
D0819_02970	COG0716	FMN binding
D0819_02975	COG2171	N-acyltransferase activity
D0819_02980	COG1473	amidohydrolase
D0819_02990	COG0668	transmembrane transport
D0819_02995	COG0450	alkyl hydroperoxide reductase
D0819_03000	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0819_03015	COG0746	molybdenum cofactor guanylyltransferase activity
D0819_03020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
D0819_03025	COG0303	'Molybdopterin
D0819_03030	COG1763	Mo-molybdopterin cofactor biosynthetic process
D0819_03035	COG0314	molybdopterin synthase activity
D0819_03040	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
D0819_03045	COG1132	(ABC) transporter
D0819_03050	COG1132	(ABC) transporter
D0819_03060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0819_03065	COG1136	(ABC) transporter
D0819_03070	COG0577	efflux transmembrane transporter activity
D0819_03075	COG1349	DNA-binding transcription factor activity
D0819_03080	COG1105	Belongs to the carbohydrate kinase PfkB family
D0819_03085	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0819_03085	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
D0819_03085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0819_03090	COG0681	Belongs to the peptidase S26 family
D0819_03100	COG0488	(ABC) transporter
D0819_03105	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D0819_03110	COG2309	aminopeptidase activity
D0819_03120	COG1077	Cell shape determining protein MreB Mrl
D0819_03125	COG2002	toxin-antitoxin pair type II binding
D0819_03130	COG3852	Histidine kinase
D0819_03135	COG2105	PFAM AIG2 family protein
D0819_03135	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
D0819_03140	COG0569	domain protein
D0819_03145	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D0819_03150	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D0819_03160	COG0561	phosphatase activity
D0819_03165	COG0242	peptide deformylase activity
D0819_03175	COG0497	DNA recombination
D0819_03180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D0819_03185	COG0022	dehydrogenase e1 component
D0819_03190	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0819_03195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0819_03200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0819_03210	COG1982	Orn Lys Arg decarboxylase major
D0819_03215	COG4476	Belongs to the UPF0223 family
D0819_03220	COG4493	Belongs to the UPF0637 family
D0819_03230	COG0483	inositol monophosphate 1-phosphatase activity
D0819_03240	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
D0819_03260	COG1595	DNA-templated transcription, initiation
D0819_03290	COG4896	Protein conserved in bacteria
D0819_03300	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
D0819_03305	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D0819_03310	COG2066	Belongs to the glutaminase family
D0819_03315	COG4838	Belongs to the UPF0358 family
D0819_03320	COG0772	Belongs to the SEDS family
D0819_03325	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
D0819_03330	COG1612	heme a metabolic process
D0819_03335	COG0109	protoheme IX farnesyltransferase activity
D0819_03340	COG2010	Cytochrome c
D0819_03340	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D0819_03345	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D0819_03350	COG1845	cytochrome c oxidase, subunit III
D0819_03355	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D0819_03360	COG3336	cytochrome c oxidase
D0819_03370	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
D0819_03375	COG2340	Cysteine-rich secretory protein family
D0819_03390	COG3679	Belongs to the UPF0342 family
D0819_03395	COG4471	UPF0298 protein
D0819_03400	COG0742	ribosomal rna small subunit methyltransferase
D0819_03405	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D0819_03410	COG3314	Sporulation integral membrane protein YlbJ
D0819_03415	COG1752	Esterase of the alpha-beta hydrolase superfamily
D0819_03420	COG3480	Lon protease (S16) C-terminal proteolytic domain
D0819_03425	COG1323	Belongs to the UPF0348 family
D0819_03435	COG1399	metal-binding, possibly nucleic acid-binding protein
D0819_03440	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D0819_03450	COG0454	-acetyltransferase
D0819_03455	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
D0819_03460	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
D0819_03465	COG2001	Belongs to the MraZ family
D0819_03470	COG0275	rRNA processing
D0819_03475	COG4839	cell division protein FtsL
D0819_03485	COG0768	penicillin binding
D0819_03490	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D0819_03495	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D0819_03500	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D0819_03505	COG0772	Belongs to the SEDS family
D0819_03510	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D0819_03515	COG0812	UDP-N-acetylmuramate dehydrogenase activity
D0819_03520	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
D0819_03525	COG3879	Bacterial protein of unknown function (DUF881)
D0819_03530	COG3879	Bacterial protein of unknown function (DUF881)
D0819_03535	COG3856	small basic protein
D0819_03540	COG0849	cell division
D0819_03545	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D0819_03550	COG1404	Belongs to the peptidase S8 family
D0819_03550	COG4412	M6 family metalloprotease domain protein
D0819_03560	COG1191	sigma factor activity
D0819_03565	COG1191	sigma factor activity
D0819_03570	COG1119	ATPase activity
D0819_03575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0819_03580	COG1873	PFAM PRC-barrel domain
D0819_03590	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D0819_03595	COG1799	cell septum assembly
D0819_03600	COG0762	integral membrane protein
D0819_03605	COG2302	S4 RNA-binding domain
D0819_03610	COG3599	regulation of cell shape
D0819_03615	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D0819_03620	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D0819_03625	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D0819_03630	COG0564	pseudouridine synthase activity
D0819_03635	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
D0819_03640	COG2233	PERMEase
D0819_03645	COG0540	Belongs to the ATCase OTCase family
D0819_03650	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D0819_03655	COG0505	Belongs to the CarA family
D0819_03660	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D0819_03665	COG0543	2 iron, 2 sulfur cluster binding
D0819_03670	COG0167	dihydroorotate dehydrogenase activity
D0819_03675	COG0284	orotidine-5'-phosphate decarboxylase activity
D0819_03680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
D0819_03685	COG0175	sulfate reduction
D0819_03690	COG0306	phosphate transporter
D0819_03695	COG2046	Belongs to the sulfate adenylyltransferase family
D0819_03700	COG0529	Catalyzes the synthesis of activated sulfate
D0819_03705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D0819_03710	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
D0819_03715	COG1648	precorrin-2 dehydrogenase activity
D0819_03725	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D0819_03730	COG1561	YicC-like family, N-terminal region
D0819_03735	COG2052	Domain of unknown function (DUF370)
D0819_03740	COG0194	GDP metabolic process
D0819_03745	COG1758	RNA polymerase activity
D0819_03750	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D0819_03755	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D0819_03760	COG0242	peptide deformylase activity
D0819_03765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
D0819_03770	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
D0819_03770	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D0819_03775	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D0819_03780	COG0631	protein serine/threonine phosphatase activity
D0819_03785	COG0515	serine threonine protein kinase
D0819_03785	COG2815	serine threonine protein kinase
D0819_03790	COG1162	GTPase activity
D0819_03795	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D0819_03800	COG1564	THIamine pyrophosphokinase
D0819_03810	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D0819_03815	COG1302	Protein conserved in bacteria
D0819_03820	COG1461	Dihydroxyacetone kinase
D0819_03825	COG1760	l-serine dehydratase
D0819_03830	COG1760	l-serine dehydratase
D0819_03835	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D0819_03840	COG1349	DNA-binding transcription factor activity
D0819_03840	COG2050	protein possibly involved in aromatic compounds catabolism
D0819_03845	COG0416	fatty acid biosynthetic process
D0819_03850	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D0819_03855	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_03860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0819_03865	COG0571	ribonuclease III activity
D0819_03870	COG1196	nuclear chromosome segregation
D0819_03875	COG0552	protein localization to endoplasmic reticulum
D0819_03885	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
D0819_03890	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D0819_03895	COG0228	four-way junction DNA binding
D0819_03900	COG1837	Belongs to the UPF0109 family
D0819_03910	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D0819_03915	COG0336	Belongs to the RNA methyltransferase TrmD family
D0819_03920	COG0335	large ribosomal subunit rRNA binding
D0819_03925	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D0819_03930	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D0819_03940	COG2257	FlhB HrpN YscU SpaS Family
D0819_03945	COG0045	succinate-CoA ligase (ADP-forming) activity
D0819_03950	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D0819_03955	COG0758	DNA mediated transformation
D0819_03960	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D0819_03965	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
D0819_03970	COG4974	Belongs to the 'phage' integrase family
D0819_03975	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D0819_03980	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D0819_03985	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D0819_03990	COG1815	bacterial-type flagellum-dependent cell motility
D0819_03995	COG1558	bacterial-type flagellum-dependent cell motility
D0819_04000	COG1677	Flagellar hook-basal body complex protein FliE
D0819_04005	COG1766	The M ring may be actively involved in energy transduction
D0819_04010	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D0819_04015	COG1317	bacterial-type flagellum organization
D0819_04020	COG1157	protein secretion by the type III secretion system
D0819_04025	COG2882	bacterial-type flagellum organization
D0819_04030	COG3334	PFAM MgtE intracellular
D0819_04035	COG3144	bacterial-type flagellum assembly
D0819_04040	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D0819_04045	COG4786	Flagellar basal body rod
D0819_04050	COG1582	Flagellar protein (FlbD)
D0819_04055	COG1580	Controls the rotational direction of flagella during chemotaxis
D0819_04060	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D0819_04065	COG1776	CheC inhibitor of MCP methylation
D0819_04065	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D0819_04070	COG2201	protein-glutamate methylesterase activity
D0819_04075	COG3190	flagellar
D0819_04080	COG1338	Plays a role in the flagellum-specific transport system
D0819_04085	COG1987	bacterial-type flagellum assembly
D0819_04090	COG1684	flagellar biosynthetic protein fliR
D0819_04095	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D0819_04100	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D0819_04105	COG1419	protein localization to endoplasmic reticulum
D0819_04110	COG0455	bacterial-type flagellum organization
D0819_04115	COG2201	protein-glutamate methylesterase activity
D0819_04120	COG0643	Histidine kinase
D0819_04120	COG2198	Histidine kinase
D0819_04125	COG0835	chemotaxis
D0819_04130	COG1776	CheC inhibitor of MCP methylation
D0819_04135	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
D0819_04140	COG1191	sigma factor activity
D0819_04150	COG0052	Belongs to the universal ribosomal protein uS2 family
D0819_04155	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
D0819_04160	COG0528	UMP kinase activity
D0819_04165	COG0233	cytoplasmic translational termination
D0819_04170	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
D0819_04175	COG4589	Belongs to the CDS family
D0819_04180	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D0819_04185	COG0750	zinc metalloprotease
D0819_04190	COG0442	prolyl-tRNA aminoacylation
D0819_04195	COG2176	DNA-directed DNA polymerase activity
D0819_04200	COG0779	Required for maturation of 30S ribosomal subunits
D0819_04205	COG0195	Participates in both transcription termination and antitermination
D0819_04210	COG2740	Nucleic-acid-binding protein implicated in transcription termination
D0819_04215	COG1358	cellular component organization or biogenesis
D0819_04220	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D0819_04225	COG1550	Protein conserved in bacteria
D0819_04230	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D0819_04235	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D0819_04240	COG0196	riboflavin kinase activity
D0819_04245	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D0819_04250	COG1185	polyribonucleotide nucleotidyltransferase activity
D0819_04255	COG0726	polysaccharide deacetylase
D0819_04260	COG0612	Peptidase, M16
D0819_04265	COG1873	PFAM PRC-barrel domain
D0819_04270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D0819_04275	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
D0819_04280	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D0819_04285	COG0527	aspartate kinase activity
D0819_04290	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D0819_04295	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D0819_04300	COG0740	serine-type endopeptidase activity
D0819_04310	COG1674	ftsk spoiiie
D0819_04310	COG4980	gas vesicle protein
D0819_04315	COG2188	Transcriptional regulator
D0819_04320	COG2814	Major facilitator Superfamily
D0819_04325	COG0612	Peptidase, M16
D0819_04330	COG0612	Peptidase, M16
D0819_04335	COG0300	oxidoreductase activity
D0819_04350	COG1426	Protein conserved in bacteria
D0819_04355	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
D0819_04360	COG1058	Belongs to the CinA family
D0819_04360	COG1546	Belongs to the CinA family
D0819_04365	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D0819_04370	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D0819_04375	COG1418	mRNA catabolic process
D0819_04380	COG1692	metallophosphoesterase
D0819_04385	COG2359	stage V sporulation protein S
D0819_04390	COG1063	alcohol dehydrogenase
D0819_04395	COG0156	8-amino-7-oxononanoate synthase activity
D0819_04400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D0819_04405	COG4550	Control of competence regulator ComK, YlbF/YmcA
D0819_04415	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
D0819_04420	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
D0819_04435	COG3226	Transcriptional regulator
D0819_04440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0819_04450	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D0819_04455	COG3321	synthase
D0819_04460	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D0819_04460	COG2070	2-Nitropropane dioxygenase
D0819_04465	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0819_04470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D0819_04475	COG3425	synthase
D0819_04480	COG1024	Enoyl-CoA hydratase
D0819_04485	COG1024	Enoyl-CoA hydratase
D0819_04490	COG3321	synthase
D0819_04490	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_04490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0819_04490	COG0300	oxidoreductase activity
D0819_04490	COG0318	PFAM AMP-dependent synthetase and ligase
D0819_04495	COG4221	oxidoreductase activity
D0819_04495	COG0300	oxidoreductase activity
D0819_04495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0819_04495	COG3321	synthase
D0819_04500	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D0819_04500	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_04500	COG3321	synthase
D0819_04500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0819_04500	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0819_04505	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_04505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0819_04505	COG3321	synthase
D0819_04505	COG4221	oxidoreductase activity
D0819_04510	COG3321	synthase
D0819_04510	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
D0819_04510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0819_04510	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
D0819_04515	COG2124	cytochrome p450
D0819_04525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0819_04530	COG1404	Belongs to the peptidase S8 family
D0819_04540	COG4195	phage-related replication protein
D0819_04545	COG1764	response to oxidative stress
D0819_04550	COG2076	Multidrug Resistance protein
D0819_04555	COG2076	Multidrug Resistance protein
D0819_04570	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D0819_04575	COG1923	regulation of RNA biosynthetic process
D0819_04590	COG1780	Probably involved in ribonucleotide reductase function
D0819_04595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0819_04600	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0819_04605	COG4112	unkown
D0819_04610	COG0860	N-Acetylmuramoyl-L-alanine amidase
D0819_04620	COG0464	growth
D0819_04625	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
D0819_04630	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
D0819_04635	COG0789	Transcriptional regulator
D0819_04640	COG0174	glutamine synthetase
D0819_04665	COG4282	regulation of fungal-type cell wall biogenesis
D0819_04675	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0819_04690	COG0135	phosphoribosylanthranilate isomerase activity
D0819_04695	COG2211	Major facilitator Superfamily
D0819_04700	COG3507	Belongs to the glycosyl hydrolase 43 family
D0819_04705	COG1940	carbohydrate kinase activity
D0819_04710	COG2115	Belongs to the xylose isomerase family
D0819_04715	COG1070	Carbohydrate kinase
D0819_04725	COG1525	nuclease
D0819_04730	COG2814	Major facilitator Superfamily
D0819_04735	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D0819_04745	COG0756	dUTP diphosphatase activity
D0819_04780	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D0819_04790	COG3832	glyoxalase III activity
D0819_04800	COG0697	spore germination
D0819_04805	COG0531	amino acid
D0819_04835	COG4195	phage-related replication protein
D0819_04845	COG0346	lactoylglutathione lyase activity
D0819_04855	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D0819_04860	COG1388	LysM domain
D0819_04865	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D0819_04870	COG4224	UPF0291 protein
D0819_04875	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D0819_04885	COG3763	UPF0154 protein
D0819_04895	COG0785	Cytochrome C biogenesis protein
D0819_04900	COG2201	protein-glutamate methylesterase activity
D0819_04905	COG4846	Membrane protein involved in cytochrome C biogenesis
D0819_04915	COG0071	Belongs to the small heat shock protein (HSP20) family
D0819_04930	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
D0819_04935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0819_04955	COG0824	Thioesterase
D0819_04965	COG4841	protein insertion into membrane
D0819_04970	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D0819_04975	COG1832	CoA-binding protein
D0819_04980	COG0187	DNA topoisomerase II activity
D0819_04985	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D0819_04995	COG1115	amino acid carrier protein
D0819_05000	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
D0819_05010	COG5520	Belongs to the glycosyl hydrolase 30 family
D0819_05015	COG3507	Belongs to the glycosyl hydrolase 43 family
D0819_05020	COG2246	polysaccharide biosynthetic process
D0819_05025	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D0819_05030	COG0586	Pfam SNARE associated Golgi protein
D0819_05035	COG2404	hydrolase activity, acting on ester bonds
D0819_05040	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D0819_05045	COG1024	Enoyl-CoA hydratase
D0819_05050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D0819_05055	COG0511	ligase activity, forming carbon-carbon bonds
D0819_05060	COG0439	Biotin carboxylase
D0819_05065	COG0318	PFAM AMP-dependent synthetase and ligase
D0819_05070	COG1960	acyl-CoA dehydrogenase activity
D0819_05080	COG1649	PFAM Uncharacterised BCR, COG1649
D0819_05090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0819_05090	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
D0819_05095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0819_05100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0819_05105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0819_05110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0819_05115	COG2027	D-alanyl-D-alanine carboxypeptidase
D0819_05120	COG2017	converts alpha-aldose to the beta-anomer
D0819_05125	COG0534	Mate efflux family protein
D0819_05140	COG0582	viral genome integration into host DNA
D0819_05145	COG0166	Belongs to the GPI family
D0819_05150	COG0405	Gamma-glutamyltransferase
D0819_05155	COG0583	DNA-binding transcription factor activity
D0819_05160	COG0604	alcohol dehydrogenase
D0819_05165	COG0493	'glutamate synthase
D0819_05170	COG0070	glutamate synthase
D0819_05170	COG0069	glutamate synthase activity
D0819_05170	COG0067	glutamate synthase
D0819_05175	COG0583	DNA-binding transcription factor activity
D0819_05180	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
D0819_05185	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D0819_05195	COG0300	oxidoreductase activity
D0819_05200	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
D0819_05210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0819_05215	COG2814	Major facilitator Superfamily
D0819_05220	COG1070	Carbohydrate kinase
D0819_05225	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0819_05230	COG0243	molybdopterin cofactor binding
D0819_05255	COG5278	phosphoserine phosphatase activity
D0819_05255	COG0840	transmembrane signaling receptor activity
D0819_05260	COG2368	4-hydroxyphenylacetate
D0819_05265	COG4305	rare lipoprotein A
D0819_05270	COG3619	membrane
D0819_05275	COG3866	Pectate lyase
D0819_05280	COG2135	peptidase activity
D0819_05290	COG2140	Oxalate decarboxylase
D0819_05315	COG2720	vancomycin resistance protein
D0819_05325	COG3655	Transcriptional regulator
D0819_05330	COG3739	integral membrane protein
D0819_05335	COG0583	DNA-binding transcription factor activity
D0819_05340	COG0697	spore germination
D0819_05350	COG0693	protein deglycase activity
D0819_05355	COG2367	Beta-lactamase
D0819_05380	COG0574	Belongs to the PEP-utilizing enzyme family
D0819_05380	COG3848	Pyruvate phosphate dikinase
D0819_05385	COG0726	polysaccharide deacetylase
D0819_05395	COG2314	TM2 domain
D0819_05400	COG1396	sequence-specific DNA binding
D0819_05470	COG0457	Tetratricopeptide repeat
D0819_05480	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D0819_05490	COG4282	regulation of fungal-type cell wall biogenesis
D0819_05495	COG1231	oxidoreductase activity
D0819_05500	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0819_05505	COG0662	Cupin 2, conserved barrel domain protein
D0819_05505	COG2207	Transcriptional regulator
D0819_05510	COG0456	acetyltransferase
D0819_05515	COG1309	transcriptional regulator
D0819_05520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0819_05525	COG3708	Transcriptional regulator
D0819_05530	COG2378	regulation of single-species biofilm formation
D0819_05540	COG0640	Transcriptional regulator
D0819_05545	COG0741	lytic transglycosylase activity
D0819_05550	COG2322	membrane
D0819_05565	COG1619	proteins homologs of microcin C7 resistance protein MccF
D0819_05570	COG3239	Fatty acid desaturase
D0819_05575	COG4585	Histidine kinase
D0819_05580	COG2197	response regulator
D0819_05585	COG1388	LysM domain
D0819_05585	COG3584	3D domain protein
D0819_05590	COG0514	ATP-dependent DNA helicase (RecQ)
D0819_05605	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D0819_05610	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D0819_05625	COG0071	Belongs to the small heat shock protein (HSP20) family
D0819_05650	COG1012	belongs to the aldehyde dehydrogenase family
D0819_05655	COG1657	PFAM Prenyltransferase squalene oxidase
D0819_05660	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D0819_05665	COG0733	neurotransmitter:sodium symporter activity
D0819_05670	COG0385	Bile acid
D0819_05675	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0819_05680	COG0567	Dehydrogenase, E1 component
D0819_05685	COG4548	von Willebrand factor, type A
D0819_05690	COG0714	Associated with various cellular activities
D0819_05695	COG2032	superoxide dismutase activity
D0819_05700	COG0791	NLP P60 protein
D0819_05700	COG1388	LysM domain
D0819_05705	COG1819	glycosyl
D0819_05710	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
D0819_05715	COG0534	Mate efflux family protein
D0819_05720	COG1366	Belongs to the anti-sigma-factor antagonist family
D0819_05725	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D0819_05730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D0819_05740	COG2962	Rard protein
D0819_05755	COG2610	gluconate transmembrane transporter activity
D0819_05760	COG1942	4-Oxalocrotonate Tautomerase
D0819_05765	COG1733	regulation of RNA biosynthetic process
D0819_05770	COG0778	Nitroreductase
D0819_05775	COG0400	carboxylic ester hydrolase activity
D0819_05780	COG0346	lactoylglutathione lyase activity
D0819_05790	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0819_05795	COG3409	Peptidoglycan-binding domain 1 protein
D0819_05795	COG0793	Belongs to the peptidase S41A family
D0819_05800	COG2226	methyltransferase
D0819_05810	COG1876	peptidase activity
D0819_05815	COG0813	purine-nucleoside phosphorylase activity
D0819_05830	COG0671	phosphoesterase, PA-phosphatase related
D0819_05855	COG4479	Belongs to the UPF0346 family
D0819_05865	COG1509	lysine 2,3-aminomutase activity
D0819_05870	COG0456	acetyltransferase
D0819_05875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0819_05880	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D0819_05885	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D0819_05890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D0819_05900	COG0456	acetyltransferase
D0819_05905	COG0463	Glycosyl transferase, family 2
D0819_05920	COG4641	Protein conserved in bacteria
D0819_05925	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
D0819_05930	COG1086	Polysaccharide biosynthesis protein
D0819_05935	COG3331	DNA recombination
D0819_05955	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D0819_06020	COG0756	dUTP diphosphatase activity
D0819_06030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0819_06035	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0819_06045	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D0819_06045	COG1372	Participates in initiation and elongation during chromosome replication
D0819_06050	COG1780	Probably involved in ribonucleotide reductase function
D0819_06120	COG0270	DNA (cytosine-5-)-methyltransferase activity
D0819_06135	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D0819_06150	COG3584	3D domain protein
D0819_06225	COG2135	peptidase activity
D0819_06230	COG1793	dna ligase
D0819_06270	COG4474	Belongs to the UPF0398 family
D0819_06315	COG3655	Transcriptional regulator
D0819_06410	COG3655	Transcriptional regulator
D0819_06480	COG0776	regulation of translation
D0819_06515	COG4373	Mu-like prophage FluMu protein gp28
D0819_06605	COG0582	viral genome integration into host DNA
D0819_06630	COG0741	lytic transglycosylase activity
D0819_06630	COG0739	heme binding
D0819_06630	COG1196	nuclear chromosome segregation
D0819_06640	COG2433	Pfam Transposase IS66
D0819_06670	COG5632	N-Acetylmuramoyl-L-alanine amidase
D0819_06685	COG0457	Tetratricopeptide repeat
D0819_06695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D0819_06710	COG2197	response regulator
D0819_06715	COG4585	Histidine kinase
D0819_06720	COG0730	response to heat
D0819_06740	COG5444	nuclease activity
D0819_06745	COG4282	regulation of fungal-type cell wall biogenesis
D0819_06760	COG1525	nuclease
D0819_06780	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D0819_06785	COG1086	Polysaccharide biosynthesis protein
D0819_06790	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0819_06795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D0819_06800	COG1846	Transcriptional regulator
D0819_06805	COG0534	Mate efflux family protein
D0819_06815	COG4698	Protein conserved in bacteria
D0819_06820	COG2755	lipolytic protein G-D-S-L family
D0819_06825	COG1999	signal sequence binding
D0819_06835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D0819_06840	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D0819_06845	COG1272	protein, Hemolysin III
D0819_06850	COG0204	Acyl-transferase
D0819_06855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D0819_06860	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D0819_06870	COG2136	Putative SAM-dependent methyltransferase
D0819_06870	COG2521	methyltransferase
D0819_06880	COG0129	dihydroxy-acid dehydratase activity
D0819_06885	COG1413	lyase activity
D0819_06890	COG1418	mRNA catabolic process
D0819_06895	COG0386	Belongs to the glutathione peroxidase family
D0819_06900	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D0819_06905	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D0819_06910	COG1278	Cold shock
D0819_06930	COG0328	RNA-DNA hybrid ribonuclease activity
D0819_06935	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
D0819_06940	COG0328	RNA-DNA hybrid ribonuclease activity
D0819_06950	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D0819_06965	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D0819_06975	COG1755	Isoprenylcysteine carboxyl methyltransferase
D0819_06980	COG3424	synthase
D0819_06985	COG2233	PERMEase
D0819_06990	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D0819_06995	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
D0819_07005	COG0800	Aldolase
D0819_07010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0819_07015	COG1609	Transcriptional regulator
D0819_07020	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
D0819_07025	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_07030	COG1199	ATP-dependent helicase activity
D0819_07045	COG0116	Belongs to the methyltransferase superfamily
D0819_07060	COG4474	Belongs to the UPF0398 family
D0819_07070	COG3359	exonuclease
D0819_07075	COG1205	dead DEAH box helicase
D0819_07075	COG1111	helicase
D0819_07080	COG2190	(PTS) system
D0819_07085	COG0071	Belongs to the small heat shock protein (HSP20) family
D0819_07120	COG3331	DNA recombination
D0819_07125	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0819_07125	COG4499	WXG100 protein secretion system (Wss), protein YukC
D0819_07135	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D0819_07140	COG3935	DnaD domain protein
D0819_07145	COG0017	Asparaginyl-tRNA synthetase
D0819_07150	COG0436	Aminotransferase
D0819_07155	COG5353	protein conserved in bacteria
D0819_07165	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D0819_07165	COG1199	ATP-dependent helicase activity
D0819_07170	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D0819_07175	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
D0819_07180	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
D0819_07185	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D0819_07185	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D0819_07190	COG0617	tRNA 3'-terminal CCA addition
D0819_07195	COG0438	transferase activity, transferring glycosyl groups
D0819_07200	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
D0819_07205	COG1803	Methylglyoxal synthase
D0819_07210	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D0819_07215	COG1694	Mazg nucleotide pyrophosphohydrolase
D0819_07220	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D0819_07230	COG4347	Protein of unknown function (DUF1405)
D0819_07235	COG2010	Cytochrome c
D0819_07235	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D0819_07240	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D0819_07245	COG0723	plastoquinol--plastocyanin reductase activity
D0819_07255	COG5582	Belongs to the UPF0302 family
D0819_07260	COG0457	Tetratricopeptide repeat
D0819_07265	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D0819_07270	COG0287	Prephenate dehydrogenase
D0819_07275	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D0819_07285	COG0133	tryptophan synthase activity
D0819_07290	COG0135	phosphoribosylanthranilate isomerase activity
D0819_07300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D0819_07305	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D0819_07310	COG4401	Chorismate mutase type I
D0819_07315	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D0819_07320	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D0819_07325	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D0819_07330	COG0105	UTP biosynthetic process
D0819_07335	COG0142	geranyltranstransferase activity
D0819_07340	COG2226	methyltransferase
D0819_07345	COG0142	geranyltranstransferase activity
D0819_07355	COG0302	gtp cyclohydrolase
D0819_07360	COG0776	regulation of translation
D0819_07365	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
D0819_07380	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
D0819_07385	COG1160	GTP binding
D0819_07410	COG1304	FMN binding
D0819_07415	COG0539	negative regulation of cytoplasmic translation
D0819_07420	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
D0819_07430	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
D0819_07435	COG2959	enzyme of heme biosynthesis
D0819_07440	COG3409	Peptidoglycan-binding domain 1 protein
D0819_07440	COG3773	Cell wall hydrolase
D0819_07445	COG2339	peptidase activity
D0819_07450	COG0492	ferredoxin-NADP+ reductase activity
D0819_07455	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D0819_07460	COG4862	establishment of competence for transformation
D0819_07465	COG1408	metallophosphoesterase
D0819_07475	COG1388	LysM domain
D0819_07480	COG1266	CAAX protease self-immunity
D0819_07485	COG0514	ATP-dependent DNA helicase (RecQ)
D0819_07490	COG4955	Helix-turn-helix domain
D0819_07495	COG1141	Ferredoxin
D0819_07500	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
D0819_07505	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D0819_07510	COG0710	3-dehydroquinate dehydratase activity
D0819_07520	COG1595	DNA-templated transcription, initiation
D0819_07525	COG5002	protein histidine kinase activity
D0819_07530	COG0745	RESPONSE REGULATOR receiver
D0819_07535	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D0819_07540	COG1333	cytochrome c biogenesis protein
D0819_07545	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0819_07550	COG1187	pseudouridine synthase activity
D0819_07555	COG0700	Nucleoside recognition
D0819_07560	COG2715	membrane protein required for spore maturation
D0819_07565	COG1686	Belongs to the peptidase S11 family
D0819_07575	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
D0819_07580	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
D0819_07585	COG1547	Domain of unknown function (DUF309)
D0819_07590	COG0456	acetyltransferase
D0819_07595	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D0819_07600	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D0819_07600	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D0819_07605	COG0307	riboflavin synthase, alpha
D0819_07610	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0819_07610	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D0819_07620	COG0681	Belongs to the peptidase S26 family
D0819_07630	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
D0819_07640	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D0819_07650	COG4086	secreted protein
D0819_07655	COG0019	diaminopimelate decarboxylase activity
D0819_07660	COG0697	spore germination
D0819_07675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D0819_07695	COG1191	sigma factor activity
D0819_07700	COG2172	sigma factor antagonist activity
D0819_07705	COG1366	Belongs to the anti-sigma-factor antagonist family
D0819_07710	COG1686	Belongs to the peptidase S11 family
D0819_07715	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
D0819_07720	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
D0819_07725	COG4974	Belongs to the 'phage' integrase family
D0819_07735	COG0735	belongs to the Fur family
D0819_07740	COG1300	Membrane
D0819_07750	COG0281	malic enzyme
D0819_07755	COG1757	Na H antiporter
D0819_07760	COG1027	Aspartate ammonia-lyase
D0819_07765	COG0252	asparaginase activity
D0819_07770	COG1396	sequence-specific DNA binding
D0819_07775	COG1379	DNA repair
D0819_07780	COG0494	nUDIX hydrolase
D0819_07790	COG0667	Aldo Keto reductase
D0819_07800	COG1073	alpha beta
D0819_07810	COG4918	Iron-sulphur cluster biosynthesis
D0819_07815	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
D0819_07815	COG0456	acetyltransferase
D0819_07820	COG2329	Antibiotic biosynthesis monooxygenase
D0819_07825	COG0456	acetyltransferase
D0819_07835	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D0819_07845	COG2211	Major facilitator Superfamily
D0819_07855	COG0346	lactoylglutathione lyase activity
D0819_07860	COG1072	(Pantothenic acid kinase))
D0819_07865	COG3048	D-serine ammonia-lyase activity
D0819_07870	COG0300	oxidoreductase activity
D0819_07875	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0819_07880	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D0819_07885	COG4187	Peptidase family M20/M25/M40
D0819_07890	COG1902	pentaerythritol trinitrate reductase activity
D0819_07895	COG0596	Alpha beta hydrolase
D0819_07905	COG1234	tRNA 3'-trailer cleavage
D0819_07910	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D0819_07915	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D0819_07920	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
D0819_07930	COG0706	membrane insertase activity
D0819_07935	COG3361	conserved protein (COG2071)
D0819_07940	COG2195	Cleaves the N-terminal amino acid of tripeptides
D0819_07945	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
D0819_07950	COG0346	lactoylglutathione lyase activity
D0819_07955	COG1376	ErfK ybiS ycfS ynhG family protein
D0819_07960	COG4129	membrane
D0819_07965	COG1126	abc transporter atp-binding protein
D0819_07970	COG0765	amino acid transport
D0819_07975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0819_07985	COG1597	lipid kinase activity
D0819_07990	COG2814	Major facilitator Superfamily
D0819_07995	COG0789	Transcriptional regulator
D0819_07995	COG4978	Transcriptional regulator
D0819_08000	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0819_08005	COG0022	dehydrogenase e1 component
D0819_08010	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D0819_08015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0819_08020	COG3426	butyrate kinase activity
D0819_08025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D0819_08030	COG0280	phosphate acetyltransferase
D0819_08035	COG3290	protein histidine kinase activity
D0819_08035	COG3829	transcription factor binding
D0819_08045	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
D0819_08050	COG2079	MmgE PrpD family protein
D0819_08055	COG0372	Belongs to the citrate synthase family
D0819_08060	COG1960	acyl-CoA dehydrogenase activity
D0819_08065	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0819_08070	COG0183	Belongs to the thiolase family
D0819_08075	COG0584	glycerophosphoryl diester phosphodiesterase
D0819_08080	COG0860	N-Acetylmuramoyl-L-alanine amidase
D0819_08090	COG1902	pentaerythritol trinitrate reductase activity
D0819_08095	COG0745	RESPONSE REGULATOR receiver
D0819_08100	COG0750	zinc metalloprotease
D0819_08105	COG0497	DNA recombination
D0819_08110	COG1438	arginine binding
D0819_08115	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
D0819_08120	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
D0819_08125	COG0142	geranyltranstransferase activity
D0819_08130	COG1722	exodeoxyribonuclease VII activity
D0819_08135	COG1570	exodeoxyribonuclease VII activity
D0819_08140	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D0819_08145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D0819_08150	COG1302	Protein conserved in bacteria
D0819_08155	COG0439	Biotin carboxylase
D0819_08160	COG0511	ligase activity, forming carbon-carbon bonds
D0819_08200	COG3854	ATPases associated with a variety of cellular activities
D0819_08210	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D0819_08215	COG0006	proline dipeptidase activity
D0819_08220	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D0819_08230	COG3872	metal-dependent enzyme
D0819_08240	COG1752	Esterase of the alpha-beta hydrolase superfamily
D0819_08245	COG1321	iron dependent repressor
D0819_08250	COG0095	Lipoate-protein ligase
D0819_08255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0819_08260	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D0819_08265	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
D0819_08270	COG0404	The glycine cleavage system catalyzes the degradation of glycine
D0819_08275	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D0819_08295	COG1396	sequence-specific DNA binding
D0819_08305	COG0681	Belongs to the peptidase S26 family
D0819_08330	COG4940	Competence protein ComGF
D0819_08340	COG4970	Tfp pilus assembly protein FimT
D0819_08345	COG4537	Required for transformation and DNA binding
D0819_08350	COG1459	type II secretion system
D0819_08355	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
D0819_08365	COG0598	Magnesium transport protein CorA
D0819_08370	COG1253	flavin adenine dinucleotide binding
D0819_08375	COG1366	Belongs to the anti-sigma-factor antagonist family
D0819_08385	COG1393	Belongs to the ArsC family
D0819_08395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0819_08405	COG0011	TIGRFAM Protein of
D0819_08415	COG2866	Carboxypeptidase
D0819_08420	COG1368	sulfuric ester hydrolase activity
D0819_08425	COG1940	carbohydrate kinase activity
D0819_08430	COG4483	Protein conserved in bacteria
D0819_08435	COG0457	Tetratricopeptide repeat
D0819_08435	COG0705	Rhomboid family
D0819_08445	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
D0819_08450	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D0819_08455	COG0438	transferase activity, transferring glycosyl groups
D0819_08470	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D0819_08475	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D0819_08480	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
D0819_08485	COG0581	inorganic phosphate transmembrane transporter activity
D0819_08490	COG0573	inorganic phosphate transmembrane transporter activity
D0819_08495	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D0819_08505	COG0477	Major facilitator Superfamily
D0819_08510	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D0819_08515	COG2839	Protein conserved in bacteria
D0819_08520	COG5521	maltodextrose utilization protein MalA
D0819_08525	COG1388	LysM domain
D0819_08530	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D0819_08535	COG4709	membrane
D0819_08540	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
D0819_08545	COG0735	belongs to the Fur family
D0819_08550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D0819_08560	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
D0819_08565	COG0513	Belongs to the DEAD box helicase family
D0819_08575	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D0819_08580	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D0819_08585	COG2384	SAM-dependent methyltransferase
D0819_08590	COG2010	Cytochrome c
D0819_08600	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D0819_08605	COG0358	DNA primase activity
D0819_08610	COG1671	Belongs to the UPF0178 family
D0819_08615	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
D0819_08620	COG0517	IMP dehydrogenase activity
D0819_08625	COG0751	glycine-tRNA ligase activity
D0819_08630	COG0752	glycyl-tRNA synthetase alpha subunit
D0819_08635	COG1381	Involved in DNA repair and RecF pathway recombination
D0819_08645	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D0819_08650	COG0295	cytidine deaminase activity
D0819_08655	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D0819_08660	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D0819_08665	COG1480	7TM receptor with intracellular HD hydrolase
D0819_08670	COG1702	phosphate starvation-inducible protein PhoH
D0819_08675	COG0561	phosphatase activity
D0819_08690	COG4864	UPF0365 protein
D0819_08695	COG1030	water channel activity
D0819_08700	COG1610	YqeY-like protein
D0819_08705	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D0819_08710	COG1283	sodium-dependent phosphate transmembrane transporter activity
D0819_08715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D0819_08720	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D0819_08725	COG2264	protein methyltransferase activity
D0819_08730	COG0484	heat shock protein binding
D0819_08735	COG0443	Heat shock 70 kDa protein
D0819_08740	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D0819_08745	COG1420	regulation of RNA biosynthetic process
D0819_08750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D0819_08755	COG0481	GTPase activity
D0819_08765	COG0860	N-Acetylmuramoyl-L-alanine amidase
D0819_08770	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D0819_08775	COG0268	Binds directly to 16S ribosomal RNA
D0819_08780	COG1466	dna polymerase III delta subunit
D0819_08790	COG0658	competence protein
D0819_08790	COG2333	competence protein COMEC
D0819_08795	COG2131	deaminase
D0819_08800	COG1555	photosystem II stabilization
D0819_08800	COG1596	polysaccharide export
D0819_08805	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D0819_08810	COG2226	methyltransferase
D0819_08815	COG0799	negative regulation of ribosome biogenesis
D0819_08820	COG1713	HD superfamily hydrolase involved in NAD metabolism
D0819_08825	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
D0819_08830	COG1534	Rna-binding protein
D0819_08835	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D0819_08840	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
D0819_08845	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
D0819_08855	COG2755	lipolytic protein G-D-S-L family
D0819_08860	COG3409	Peptidoglycan-binding domain 1 protein
D0819_08860	COG5632	N-Acetylmuramoyl-L-alanine amidase
D0819_08865	COG0398	Pfam SNARE associated Golgi protein
D0819_08870	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
D0819_08880	COG3209	COG3209 Rhs family protein
D0819_08890	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
D0819_08900	COG3223	Belongs to the PsiE family
D0819_08905	COG0642	Histidine kinase
D0819_08905	COG5002	protein histidine kinase activity
D0819_08910	COG0745	RESPONSE REGULATOR receiver
D0819_08915	COG2311	Membrane
D0819_08920	COG0454	-acetyltransferase
D0819_08925	COG2249	NAD(P)H dehydrogenase (quinone) activity
D0819_08935	COG0730	response to heat
D0819_08940	COG0425	Belongs to the sulfur carrier protein TusA family
D0819_08945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0819_08945	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0819_08955	COG0425	Belongs to the sulfur carrier protein TusA family
D0819_08955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0819_08965	COG2210	Belongs to the sulfur carrier protein TusA family
D0819_08970	COG1937	Protein conserved in bacteria
D0819_08985	COG0662	Cupin 2, conserved barrel domain protein
D0819_09005	COG4978	Transcriptional regulator
D0819_09005	COG0789	Transcriptional regulator
D0819_09010	COG2814	Major facilitator Superfamily
D0819_09015	COG0456	acetyltransferase
D0819_09020	COG1253	flavin adenine dinucleotide binding
D0819_09030	COG0697	spore germination
D0819_09035	COG0583	DNA-binding transcription factor activity
D0819_09040	COG2072	flavoprotein involved in K transport
D0819_09045	COG1230	cation diffusion facilitator family transporter
D0819_09055	COG1114	Component of the transport system for branched-chain amino acids
D0819_09060	COG1687	branched-chain amino acid
D0819_09065	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
D0819_09070	COG1522	sequence-specific DNA binding
D0819_09075	COG2732	(Barnase) inhibitor
D0819_09080	COG2124	cytochrome p450
D0819_09090	COG1335	isochorismatase
D0819_09105	COG2318	DinB family
D0819_09115	COG2070	2-Nitropropane dioxygenase
D0819_09130	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D0819_09155	COG0789	Transcriptional regulator
D0819_09155	COG4978	Transcriptional regulator
D0819_09160	COG2315	Protein conserved in bacteria
D0819_09170	COG3443	Belongs to the bacterial solute-binding protein 9 family
D0819_09175	COG1595	DNA-templated transcription, initiation
D0819_09180	COG0667	Aldo Keto reductase
D0819_09185	COG2851	Citrate transporter
D0819_09190	COG0583	DNA-binding transcription factor activity
D0819_09195	COG2828	Protein conserved in bacteria
D0819_09200	COG3409	Peptidoglycan-binding domain 1 protein
D0819_09205	COG5566	PFAM Mor transcription activator
D0819_09210	COG0596	Alpha beta hydrolase
D0819_09215	COG4991	sh3 domain protein
D0819_09220	COG4991	sh3 domain protein
D0819_09225	COG0346	lactoylglutathione lyase activity
D0819_09235	COG5577	PFAM Coat F domain
D0819_09240	COG1063	alcohol dehydrogenase
D0819_09250	COG5577	PFAM Coat F domain
D0819_09255	COG0789	Transcriptional regulator
D0819_09265	COG1064	alcohol dehydrogenase
D0819_09270	COG0693	protein deglycase activity
D0819_09275	COG1621	beta-fructofuranosidase activity
D0819_09280	COG3716	PTS system mannose fructose sorbose family IID component
D0819_09285	COG3715	PTS system
D0819_09290	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0819_09295	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0819_09300	COG3933	PFAM sigma-54 factor interaction domain-containing protein
D0819_09300	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
D0819_09305	COG1113	amino acid transport
D0819_09310	COG1280	lysine exporter protein (LysE YggA)
D0819_09315	COG1378	Sugar-specific transcriptional regulator TrmB
D0819_09320	COG1595	DNA-templated transcription, initiation
D0819_09330	COG2755	lipolytic protein G-D-S-L family
D0819_09330	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
D0819_09340	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D0819_09340	COG2124	cytochrome p450
D0819_09345	COG1309	transcriptional regulator
D0819_09350	COG2226	methyltransferase
D0819_09360	COG2116	formate transmembrane transporter activity
D0819_09365	COG5609	conserved protein (DUF2294)
D0819_09370	COG3383	formate dehydrogenase (NAD+) activity
D0819_09375	COG2427	Protein of unknown function (DUF1641)
D0819_09385	COG0626	cystathionine gamma-synthase activity
D0819_09390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D0819_09395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D0819_09400	COG2226	methyltransferase
D0819_09415	COG0768	penicillin binding
D0819_09420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
D0819_09425	COG0572	uridine kinase
D0819_09445	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
D0819_09450	COG3906	Belongs to the UPF0473 family
D0819_09455	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
D0819_09460	COG4472	Bacterial protein of unknown function (DUF965)
D0819_09465	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D0819_09470	COG0628	permease
D0819_09475	COG1126	abc transporter atp-binding protein
D0819_09480	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0819_09485	COG0765	amino acid transport
D0819_09490	COG0765	amino acid transport
D0819_09505	COG3881	PFAM PRC-barrel domain
D0819_09510	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D0819_09515	COG0457	Tetratricopeptide repeat
D0819_09520	COG0482	sulfurtransferase activity
D0819_09525	COG1104	cysteine desulfurase activity
D0819_09530	COG1959	2 iron, 2 sulfur cluster binding
D0819_09535	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D0819_09540	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
D0819_09550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D0819_09555	COG0124	histidyl-tRNA synthetase
D0819_09565	COG0860	N-Acetylmuramoyl-L-alanine amidase
D0819_09565	COG3103	Sh3 type 3 domain protein
D0819_09565	COG4991	sh3 domain protein
D0819_09570	COG1490	D-aminoacyl-tRNA deacylase activity
D0819_09575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D0819_09580	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D0819_09585	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
D0819_09585	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
D0819_09590	COG5416	Lipopolysaccharide assembly protein A domain
D0819_09595	COG0490	domain, Protein
D0819_09600	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0819_09600	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D0819_09610	COG2244	polysaccharide biosynthetic process
D0819_09615	COG2323	membrane
D0819_09625	COG1862	Preprotein translocase
D0819_09630	COG0343	queuine tRNA-ribosyltransferase activity
D0819_09635	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
D0819_09645	COG2255	four-way junction helicase activity
D0819_09650	COG0632	four-way junction helicase activity
D0819_09660	COG2814	Major facilitator Superfamily
D0819_09665	COG0673	inositol 2-dehydrogenase activity
D0819_09670	COG2112	serine threonine protein kinase
D0819_09685	COG1115	amino acid carrier protein
D0819_09690	COG0217	transcriptional regulatory protein
D0819_09700	COG1388	LysM domain
D0819_09705	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
D0819_09710	COG0157	Belongs to the NadC ModD family
D0819_09715	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
D0819_09720	COG1104	cysteine desulfurase activity
D0819_09725	COG1827	regulation of RNA biosynthetic process
D0819_09730	COG0077	Prephenate dehydratase
D0819_09735	COG4492	Belongs to the UPF0735 family
D0819_09740	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D0819_09745	COG3290	protein histidine kinase activity
D0819_09750	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D0819_09755	COG2868	ribosomal protein
D0819_09760	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D0819_09765	COG1994	Peptidase M50
D0819_09770	COG0739	heme binding
D0819_09775	COG2894	cell division
D0819_09780	COG0850	regulation of cytokinetic process
D0819_09785	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
D0819_09790	COG1792	Involved in formation and maintenance of cell shape
D0819_09795	COG1077	Cell shape determining protein MreB Mrl
D0819_09800	COG2003	Belongs to the UPF0758 family
D0819_09805	COG0424	maF-like protein
D0819_09815	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
D0819_09820	COG0285	dihydrofolate synthase activity
D0819_09825	COG0525	valine-tRNA ligase activity
D0819_09835	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D0819_09840	COG1388	LysM domain
D0819_09845	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D0819_09850	COG0113	porphobilinogen synthase activity
D0819_09855	COG1587	Uroporphyrinogen-III synthase
D0819_09860	COG0181	hydroxymethylbilane synthase activity
D0819_09865	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D0819_09870	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D0819_09880	COG0218	Necessary for normal cell division and for the maintenance of normal septation
D0819_09885	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D0819_09890	COG1067	ATP-dependent peptidase activity
D0819_09890	COG0470	DNA polymerase III
D0819_09895	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D0819_09900	COG0544	peptidyl-prolyl cis-trans isomerase activity
D0819_09905	COG0457	Tetratricopeptide repeat
D0819_09905	COG1477	protein flavinylation
D0819_09910	COG0066	3-isopropylmalate dehydratase activity
D0819_09915	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
D0819_09920	COG0473	3-isopropylmalate dehydrogenase activity
D0819_09925	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D0819_09930	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D0819_09935	COG0440	acetolactate synthase activity
D0819_09940	COG0028	Belongs to the TPP enzyme family
D0819_09950	COG0454	-acetyltransferase
D0819_09955	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
D0819_09965	COG0622	Phosphoesterase
D0819_09970	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D0819_09975	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
D0819_09980	COG5401	PFAM Sporulation and spore germination
D0819_09985	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D0819_09990	COG1846	Transcriptional regulator
D0819_09995	COG2197	response regulator
D0819_10000	COG0824	Thioesterase
D0819_10005	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D0819_10010	COG1053	succinate dehydrogenase
D0819_10015	COG2009	succinate dehydrogenase
D0819_10020	COG1719	4-vinyl reductase, 4VR
D0819_10025	COG0527	aspartate kinase activity
D0819_10035	COG0322	excinuclease ABC activity
D0819_10040	COG3118	belongs to the thioredoxin family
D0819_10050	COG3534	alpha-L-arabinofuranosidase
D0819_10055	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
D0819_10060	COG2086	electron transfer activity
D0819_10065	COG1024	Enoyl-CoA hydratase
D0819_10070	COG1309	transcriptional regulator
D0819_10075	COG0318	PFAM AMP-dependent synthetase and ligase
D0819_10080	COG3766	membrane
D0819_10085	COG1193	negative regulation of DNA recombination
D0819_10090	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D0819_10090	COG1796	DNA polymerase
D0819_10095	COG1286	toxin biosynthetic process
D0819_10100	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
D0819_10105	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D0819_10110	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0819_10110	COG0072	phenylalanine-tRNA ligase activity
D0819_10115	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D0819_10125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0819_10135	COG3835	regulator
D0819_10140	COG0277	FAD linked oxidase domain protein
D0819_10145	COG0247	lactate metabolic process
D0819_10150	COG0346	lactoylglutathione lyase activity
D0819_10160	COG1966	Carbon starvation protein
D0819_10165	COG3534	alpha-L-arabinofuranosidase
D0819_10170	COG0395	ABC-type sugar transport system, permease component
D0819_10175	COG1175	transmembrane transport
D0819_10180	COG1653	transport
D0819_10185	COG0371	Dehydrogenase
D0819_10190	COG0647	UMP catabolic process
D0819_10195	COG0235	Class ii aldolase
D0819_10200	COG1069	ribulokinase activity
D0819_10205	COG2160	L-arabinose isomerase activity
D0819_10210	COG3507	Belongs to the glycosyl hydrolase 43 family
D0819_10215	COG1363	Peptidase, m42
D0819_10225	COG3326	Membrane
D0819_10230	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D0819_10235	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D0819_10240	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D0819_10250	COG1346	cytolysis
D0819_10255	COG1380	Effector of murein hydrolase LrgA
D0819_10260	COG3279	Response regulator of the LytR AlgR family
D0819_10265	COG3275	phosphorelay sensor kinase activity
D0819_10275	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D0819_10285	COG0398	Pfam SNARE associated Golgi protein
D0819_10290	COG1484	DNA-dependent DNA replication
D0819_10295	COG3611	Membrane attachment protein
D0819_10300	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
D0819_10305	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
D0819_10310	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D0819_10315	COG1733	regulation of RNA biosynthetic process
D0819_10325	COG0656	L-ascorbic acid biosynthetic process
D0819_10330	COG0237	dephospho-CoA kinase activity
D0819_10335	COG1971	Probably functions as a manganese efflux pump
D0819_10340	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
D0819_10345	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D0819_10345	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D0819_10350	COG5002	protein histidine kinase activity
D0819_10355	COG0745	RESPONSE REGULATOR receiver
D0819_10365	COG0039	L-malate dehydrogenase activity
D0819_10370	COG0538	isocitrate dehydrogenase activity
D0819_10375	COG0372	Belongs to the citrate synthase family
D0819_10380	COG2707	UPF0756 membrane protein
D0819_10385	COG0628	permease
D0819_10390	COG3030	protein affecting phage T7 exclusion by the F plasmid
D0819_10395	COG0469	pyruvate kinase activity
D0819_10400	COG0205	6-phosphofructokinase activity
D0819_10405	COG0825	malonyl-CoA metabolic process
D0819_10410	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D0819_10415	COG0281	malic enzyme
D0819_10420	COG0587	DNA-directed DNA polymerase activity
D0819_10440	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
D0819_10450	COG4109	DRTGG domain
D0819_10455	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D0819_10460	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_10470	COG0165	Argininosuccinate lyase
D0819_10475	COG0137	argininosuccinate synthase activity
D0819_10480	COG0521	Mo-molybdopterin cofactor biosynthetic process
D0819_10485	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D0819_10495	COG0827	DNA restriction-modification system
D0819_10500	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D0819_10505	COG3874	Sporulation protein YtfJ
D0819_10515	COG1714	RDD family
D0819_10520	COG0616	signal peptide processing
D0819_10525	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D0819_10530	COG1574	metal-dependent hydrolase with the TIM-barrel fold
D0819_10535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D0819_10545	COG0301	tRNA thio-modification
D0819_10550	COG1104	cysteine desulfurase activity
D0819_10555	COG1114	Component of the transport system for branched-chain amino acids
D0819_10560	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
D0819_10565	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
D0819_10570	COG1309	transcriptional regulator
D0819_10575	COG1956	GAF domain-containing protein
D0819_10580	COG2203	Gaf domain
D0819_10580	COG2199	diguanylate cyclase activity
D0819_10590	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D0819_10595	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D0819_10605	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D0819_10610	COG0454	-acetyltransferase
D0819_10615	COG0517	IMP dehydrogenase activity
D0819_10620	COG0123	including yeast histone deacetylase and acetoin utilization protein
D0819_10625	COG1360	Flagellar Motor Protein
D0819_10630	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D0819_10635	COG1609	Transcriptional regulator
D0819_10640	COG1605	Chorismate mutase
D0819_10640	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
D0819_10645	COG3118	belongs to the thioredoxin family
D0819_10650	COG4980	gas vesicle protein
D0819_10655	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
D0819_10660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
D0819_10665	COG1674	ftsk spoiiie
D0819_10670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0819_10675	COG4848	Belongs to the UPF0354 family
D0819_10680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0819_10690	COG1363	Peptidase, m42
D0819_10695	COG5584	Small secreted protein
D0819_10700	COG0281	malic enzyme
D0819_10705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0819_10710	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D0819_10720	COG0510	thiamine kinase activity
D0819_10725	COG1523	belongs to the glycosyl hydrolase 13 family
D0819_10730	COG1597	lipid kinase activity
D0819_10740	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
D0819_10745	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D0819_10750	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0819_10755	COG2252	PERMEase
D0819_10760	COG4473	ABC transporter
D0819_10765	COG1131	(ABC) transporter
D0819_10770	COG1349	DNA-binding transcription factor activity
D0819_10775	COG1187	pseudouridine synthase activity
D0819_10780	COG2244	polysaccharide biosynthetic process
D0819_10785	COG2081	HI0933 family
D0819_10790	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
D0819_10800	COG5578	integral membrane protein
D0819_10805	COG0673	inositol 2-dehydrogenase activity
D0819_10810	COG1653	transport
D0819_10815	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D0819_10820	COG4209	transmembrane transport
D0819_10825	COG2207	Transcriptional regulator
D0819_10830	COG1653	transport
D0819_10835	COG0395	ABC-type sugar transport system, permease component
D0819_10840	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D0819_10845	COG2124	cytochrome p450
D0819_10850	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D0819_10860	COG0156	8-amino-7-oxononanoate synthase activity
D0819_10865	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D0819_10875	COG1073	alpha beta
D0819_10900	COG1486	melibiose metabolic process
D0819_10905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D0819_10910	COG0495	leucyl-tRNA aminoacylation
D0819_10920	COG2202	Pas domain
D0819_10920	COG1366	Belongs to the anti-sigma-factor antagonist family
D0819_10925	COG2814	Major facilitator Superfamily
D0819_10930	COG2433	Pfam Transposase IS66
D0819_10935	COG0577	efflux transmembrane transporter activity
D0819_10940	COG1136	(ABC) transporter
D0819_10945	COG2205	protein histidine kinase activity
D0819_10950	COG0745	RESPONSE REGULATOR receiver
D0819_10955	COG0577	efflux transmembrane transporter activity
D0819_10960	COG1136	(ABC) transporter
D0819_10975	COG1131	(ABC) transporter
D0819_10980	COG1725	Transcriptional regulator
D0819_10990	COG1242	4 iron, 4 sulfur cluster binding
D0819_10995	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
D0819_11005	COG2267	carboxylic ester hydrolase activity
D0819_11010	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
D0819_11015	COG1113	amino acid transport
D0819_11020	COG0367	asparagine synthase
D0819_11025	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D0819_11030	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D0819_11040	COG1506	peptidase
D0819_11045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
D0819_11050	COG1116	anion transmembrane transporter activity
D0819_11055	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
D0819_11060	COG0494	nUDIX hydrolase
D0819_11065	COG4824	toxin secretion phage lysis holin
D0819_11070	COG0783	Belongs to the Dps family
D0819_11085	COG1854	S-ribosylhomocysteine lyase activity
D0819_11090	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
D0819_11095	COG0288	reversible hydration of carbon dioxide
D0819_11100	COG0254	rRNA binding
D0819_11105	COG1271	oxidase subunit
D0819_11110	COG1294	oxidase, subunit
D0819_11120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D0819_11125	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D0819_11125	COG1321	iron dependent repressor
D0819_11130	COG1121	(ABC) transporter
D0819_11135	COG0803	Belongs to the bacterial solute-binding protein 9 family
D0819_11140	COG4948	Mandelate Racemase Muconate Lactonizing
D0819_11145	COG0318	PFAM AMP-dependent synthetase and ligase
D0819_11150	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
D0819_11155	COG0596	Alpha beta hydrolase
D0819_11160	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
D0819_11165	COG1169	isochorismate synthase
D0819_11175	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D0819_11180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D0819_11185	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D0819_11190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D0819_11195	COG0438	transferase activity, transferring glycosyl groups
D0819_11205	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D0819_11210	COG0438	transferase activity, transferring glycosyl groups
D0819_11215	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D0819_11220	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
D0819_11225	COG0058	SHG alpha-glucan phosphorylase activity
D0819_11230	COG0297	glycogen (starch) synthase activity
D0819_11235	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D0819_11240	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
D0819_11245	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
D0819_11370	COG3859	Proton-coupled thiamine transporter YuaJ
D0819_11375	COG1247	-acetyltransferase
D0819_11380	COG2268	Band 7 protein
D0819_11385	COG1585	Membrane protein implicated in regulation of membrane protease activity
D0819_11390	COG2318	DinB family
D0819_11400	COG1454	alcohol dehydrogenase
D0819_11410	COG1510	regulation of RNA biosynthetic process
D0819_11420	COG0569	domain protein
D0819_11425	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D0819_11430	COG4682	membrane
D0819_11435	COG1705	Flagellar rod assembly protein muramidase FlgJ
D0819_11440	COG0477	Major facilitator Superfamily
D0819_11445	COG5553	Cysteine dioxygenase type I
D0819_11455	COG1968	undecaprenyl-diphosphatase activity
D0819_11460	COG0628	permease
D0819_11465	COG0673	inositol 2-dehydrogenase activity
D0819_11470	COG4806	L-rhamnose isomerase
D0819_11475	COG3254	rhamnose metabolic process
D0819_11480	COG1070	Carbohydrate kinase
D0819_11485	COG1349	DNA-binding transcription factor activity
D0819_11490	COG3347	Dehydrogenase
D0819_11490	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_11500	COG0840	transmembrane signaling receptor activity
D0819_11505	COG0840	transmembrane signaling receptor activity
D0819_11510	COG0840	transmembrane signaling receptor activity
D0819_11515	COG0840	transmembrane signaling receptor activity
D0819_11530	COG0432	Pfam Uncharacterised protein family UPF0047
D0819_11535	COG0366	Alpha amylase catalytic
D0819_11540	COG1253	flavin adenine dinucleotide binding
D0819_11545	COG2738	Putative neutral zinc metallopeptidase
D0819_11560	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D0819_11575	COG0166	Belongs to the GPI family
D0819_11580	COG1979	alcohol dehydrogenase
D0819_11585	COG1979	alcohol dehydrogenase
D0819_11590	COG2155	Conserved Protein
D0819_11595	COG1098	S1 RNA binding domain
D0819_11600	COG0436	Aminotransferase
D0819_11605	COG1522	sequence-specific DNA binding
D0819_11610	COG2267	carboxylic ester hydrolase activity
D0819_11620	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
D0819_11625	COG2205	protein histidine kinase activity
D0819_11635	COG5018	Exonuclease
D0819_11645	COG2814	Major facilitator Superfamily
D0819_11650	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0819_11655	COG3011	Protein conserved in bacteria
D0819_11665	COG3290	protein histidine kinase activity
D0819_11670	COG4565	transcriptional regulatory protein
D0819_11695	COG3493	citrate carrier protein
D0819_11705	COG2111	Na H antiporter
D0819_11705	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D0819_11710	COG2111	Na H antiporter
D0819_11715	COG1006	Multisubunit Na H antiporter MnhC subunit
D0819_11720	COG0651	ATP synthesis coupled electron transport
D0819_11725	COG1863	multisubunit Na H antiporter MnhE subunit
D0819_11730	COG2212	antiporter activity
D0819_11735	COG1320	monovalent cation:proton antiporter activity
D0819_11740	COG2050	protein possibly involved in aromatic compounds catabolism
D0819_11745	COG2197	response regulator
D0819_11760	COG0142	geranyltranstransferase activity
D0819_11775	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
D0819_11780	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
D0819_11785	COG1335	isochorismatase
D0819_11790	COG5506	Protein of unknown function (DUF1694)
D0819_11805	COG0628	permease
D0819_11820	COG1418	mRNA catabolic process
D0819_11825	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_11835	COG1511	domain protein
D0819_11840	COG1674	ftsk spoiiie
D0819_11840	COG0433	COG0433 Predicted ATPase
D0819_11845	COG4499	WXG100 protein secretion system (Wss), protein YukC
D0819_11850	COG5417	Belongs to the EsaB family
D0819_11855	COG4842	Belongs to the WXG100 family
D0819_11865	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
D0819_11865	COG2508	Transcriptional regulator
D0819_11870	COG0686	Belongs to the AlaDH PNT family
D0819_11875	COG5634	Uncharacterized conserved protein (DUF2278)
D0819_11880	COG3251	PFAM MbtH domain protein
D0819_11885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0819_11890	COG1535	isochorismatase
D0819_11890	COG3433	isochorismatase activity
D0819_11895	COG1021	2,3-dihydroxybenzoate-AMP ligase
D0819_11900	COG1169	isochorismate synthase
D0819_11905	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_11910	COG2819	hydrolase of the alpha beta superfamily
D0819_11915	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D0819_11920	COG1268	BioY protein
D0819_11925	COG2056	Na+-H+ antiporter family
D0819_11930	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D0819_11935	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
D0819_11940	COG3584	3D domain protein
D0819_11955	COG1252	NADH dehydrogenase
D0819_11960	COG0492	ferredoxin-NADP+ reductase activity
D0819_11970	COG0516	GMP reductase activity
D0819_11985	COG1131	(ABC) transporter
D0819_12005	COG2808	Putative FMN-binding domain
D0819_12010	COG0456	acetyltransferase
D0819_12015	COG0316	Belongs to the HesB IscA family
D0819_12020	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D0819_12025	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D0819_12030	COG4844	belongs to the
D0819_12035	COG1252	NADH dehydrogenase
D0819_12040	COG4837	Protein of unknown function (DUF1462)
D0819_12045	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D0819_12050	COG0823	Involved in the tonB-independent uptake of proteins
D0819_12050	COG1506	peptidase
D0819_12050	COG4946	Tricorn protease homolog
D0819_12055	COG0083	homoserine kinase activity
D0819_12060	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D0819_12065	COG0460	homoserine dehydrogenase
D0819_12070	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D0819_12075	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D0819_12080	COG0647	UMP catabolic process
D0819_12085	COG2445	Protein of unknown function DUF86
D0819_12090	COG4470	Protein conserved in bacteria
D0819_12100	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D0819_12105	COG0739	heme binding
D0819_12115	COG3377	Domain of unknown function (DUF1805)
D0819_12120	COG0737	Belongs to the 5'-nucleotidase family
D0819_12125	COG0730	response to heat
D0819_12130	COG1801	Protein of unknown function DUF72
D0819_12140	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D0819_12145	COG2508	Transcriptional regulator
D0819_12150	COG2233	PERMEase
D0819_12155	COG2233	PERMEase
D0819_12160	COG3195	allantoin biosynthetic process
D0819_12160	COG3648	Uricase
D0819_12165	COG2351	hydroxyisourate hydrolase activity
D0819_12175	COG2080	2 iron, 2 sulfur cluster binding
D0819_12180	COG1529	Aldehyde oxidase and xanthine dehydrogenase
D0819_12185	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
D0819_12190	COG2068	MobA-Related Protein
D0819_12195	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
D0819_12200	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
D0819_12205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D0819_12210	COG2356	endonuclease I
D0819_12215	COG3842	ATPase activity
D0819_12220	COG2188	Transcriptional regulator
D0819_12225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0819_12230	COG0395	ABC-type sugar transport system, permease component
D0819_12235	COG1175	transmembrane transport
D0819_12240	COG1653	transport
D0819_12245	COG2222	sugar isomerase
D0819_12250	COG0322	excinuclease ABC activity
D0819_12255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D0819_12270	COG0346	lactoylglutathione lyase activity
D0819_12275	COG0640	Transcriptional regulator
D0819_12280	COG0719	Fe-S assembly protein
D0819_12285	COG0822	iron-sulfur transferase activity
D0819_12290	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D0819_12295	COG0719	Fe-S assembly protein
D0819_12300	COG0396	ATPase activity
D0819_12315	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0819_12320	COG1464	Belongs to the NlpA lipoprotein family
D0819_12325	COG2011	ABC-type metal ion transport system permease component
D0819_12330	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D0819_12340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0819_12345	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D0819_12355	COG0509	glycine decarboxylation via glycine cleavage system
D0819_12360	COG1393	Belongs to the ArsC family
D0819_12365	COG1960	acyl-CoA dehydrogenase activity
D0819_12370	COG0183	Belongs to the thiolase family
D0819_12375	COG1024	Enoyl-CoA hydratase
D0819_12375	COG1250	3-hydroxyacyl-CoA dehydrogenase
D0819_12395	COG5577	PFAM Coat F domain
D0819_12400	COG1846	Transcriptional regulator
D0819_12405	COG0477	Major facilitator Superfamily
D0819_12410	COG1942	4-Oxalocrotonate Tautomerase
D0819_12415	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_12420	COG0583	DNA-binding transcription factor activity
D0819_12430	COG1120	ATPase activity
D0819_12445	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_12450	COG0783	Belongs to the Dps family
D0819_12455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0819_12460	COG0745	RESPONSE REGULATOR receiver
D0819_12465	COG2205	protein histidine kinase activity
D0819_12465	COG2770	Histidine kinase
D0819_12475	COG1309	transcriptional regulator
D0819_12480	COG0114	fumarate hydratase activity
D0819_12490	COG0697	spore germination
D0819_12495	COG0814	amino acid
D0819_12505	COG2197	response regulator
D0819_12510	COG4585	Histidine kinase
D0819_12515	COG4758	membrane
D0819_12520	COG3595	metallopeptidase activity
D0819_12525	COG1842	Phage shock protein A
D0819_12530	COG4758	membrane
D0819_12535	COG2814	Major facilitator Superfamily
D0819_12540	COG2096	Adenosyltransferase
D0819_12545	COG1120	ATPase activity
D0819_12550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0819_12555	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D0819_12560	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_12565	COG3386	PFAM SMP-30 Gluconolaconase
D0819_12570	COG2205	protein histidine kinase activity
D0819_12575	COG0745	RESPONSE REGULATOR receiver
D0819_12585	COG1191	sigma factor activity
D0819_12595	COG2140	Oxalate decarboxylase
D0819_12605	COG0577	efflux transmembrane transporter activity
D0819_12610	COG1136	(ABC) transporter
D0819_12615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D0819_12620	COG1120	ATPase activity
D0819_12625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0819_12630	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0819_12635	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D0819_12645	COG0531	amino acid
D0819_12660	COG1988	membrane-bound metal-dependent
D0819_12665	COG1368	sulfuric ester hydrolase activity
D0819_12670	COG1910	domain protein
D0819_12675	COG0725	ABC transporter, periplasmic molybdate-binding protein
D0819_12680	COG4149	molybdate abc transporter
D0819_12685	COG0656	L-ascorbic acid biosynthetic process
D0819_12695	COG0025	NhaP-type Na H and K H
D0819_12700	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D0819_12705	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D0819_12710	COG3973	AAA domain
D0819_12720	COG2860	membrane
D0819_12725	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D0819_12730	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
D0819_12735	COG2217	Heavy metal translocating P-type atpase
D0819_12740	COG2217	Heavy metal translocating P-type atpase
D0819_12745	COG2608	mercury ion transmembrane transporter activity
D0819_12750	COG1937	Protein conserved in bacteria
D0819_12755	COG0673	inositol 2-dehydrogenase activity
D0819_12760	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
D0819_12765	COG1289	transmembrane transporter activity
D0819_12775	COG2076	Multidrug Resistance protein
D0819_12780	COG1309	transcriptional regulator
D0819_12785	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_12810	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
D0819_12815	COG0557	exoribonuclease II activity
D0819_12820	COG1647	Serine aminopeptidase, S33
D0819_12825	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D0819_12830	COG0596	Alpha beta hydrolase
D0819_12835	COG1476	TRANSCRIPTIONal
D0819_12840	COG1396	sequence-specific DNA binding
D0819_12845	COG1396	sequence-specific DNA binding
D0819_12850	COG1733	regulation of RNA biosynthetic process
D0819_12855	COG0840	transmembrane signaling receptor activity
D0819_12860	COG1174	glycine betaine transport
D0819_12865	COG1732	Glycine betaine
D0819_12870	COG1174	glycine betaine transport
D0819_12875	COG0517	IMP dehydrogenase activity
D0819_12875	COG1125	glycine betaine transport
D0819_12880	COG1510	regulation of RNA biosynthetic process
D0819_12885	COG1174	glycine betaine transport
D0819_12890	COG1732	Glycine betaine
D0819_12895	COG1174	glycine betaine transport
D0819_12900	COG1125	glycine betaine transport
D0819_12900	COG0517	IMP dehydrogenase activity
D0819_12905	COG1510	regulation of RNA biosynthetic process
D0819_12910	COG2095	MarC family integral membrane protein
D0819_12920	COG3064	Membrane
D0819_12925	COG4640	response to antibiotic
D0819_12930	COG0456	acetyltransferase
D0819_12940	COG0148	phosphopyruvate hydratase activity
D0819_12945	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
D0819_12950	COG0149	triose-phosphate isomerase activity
D0819_12955	COG0126	phosphoglycerate kinase activity
D0819_12960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D0819_12965	COG2390	Transcriptional regulator
D0819_12970	COG2814	Major facilitator Superfamily
D0819_12975	COG1609	Transcriptional regulator
D0819_12980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0819_12990	COG0583	DNA-binding transcription factor activity
D0819_12995	COG0697	spore germination
D0819_13000	COG1113	amino acid transport
D0819_13005	COG3858	chitin binding
D0819_13010	COG1556	Lactate utilization protein
D0819_13015	COG1139	Iron-sulfur cluster binding protein
D0819_13020	COG0247	lactate metabolic process
D0819_13025	COG2197	response regulator
D0819_13030	COG4585	Histidine kinase
D0819_13035	COG0842	Transport permease protein
D0819_13040	COG1131	(ABC) transporter
D0819_13045	COG0596	Alpha beta hydrolase
D0819_13050	COG2208	phosphoserine phosphatase activity
D0819_13055	COG3867	Arabinogalactan endo-beta-1,4-galactanase
D0819_13060	COG1874	Beta-galactosidase
D0819_13065	COG3833	ABC-type maltose transport systems, permease component
D0819_13070	COG1175	transmembrane transport
D0819_13075	COG2182	Extracellular solute-binding protein
D0819_13080	COG1609	Transcriptional regulator
D0819_13085	COG2186	Transcriptional regulator
D0819_13090	COG1620	l-lactate permease
D0819_13095	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D0819_13105	COG5039	Polysaccharide pyruvyl transferase
D0819_13110	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D0819_13115	COG0110	maltose O-acetyltransferase activity
D0819_13120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D0819_13125	COG2244	polysaccharide biosynthetic process
D0819_13130	COG1216	Glycosyl transferase, family 2
D0819_13135	COG5039	Polysaccharide pyruvyl transferase
D0819_13140	COG1216	Glycosyl transferase, family 2
D0819_13150	COG0438	transferase activity, transferring glycosyl groups
D0819_13155	COG1215	transferase activity, transferring glycosyl groups
D0819_13160	COG0438	transferase activity, transferring glycosyl groups
D0819_13165	COG1086	Polysaccharide biosynthesis protein
D0819_13170	COG0489	protein tyrosine kinase activity
D0819_13175	COG3944	biosynthesis protein
D0819_13180	COG1396	sequence-specific DNA binding
D0819_13185	COG2272	Belongs to the type-B carboxylesterase lipase family
D0819_13195	COG3479	Phenolic acid decarboxylase
D0819_13205	COG1794	racemase activity, acting on amino acids and derivatives
D0819_13220	COG1621	beta-fructofuranosidase activity
D0819_13225	COG1621	beta-fructofuranosidase activity
D0819_13230	COG0531	amino acid
D0819_13235	COG1309	transcriptional regulator
D0819_13240	COG2076	Multidrug Resistance protein
D0819_13245	COG2076	Multidrug Resistance protein
D0819_13260	COG0740	serine-type endopeptidase activity
D0819_13265	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D0819_13270	COG0366	Alpha amylase catalytic
D0819_13275	COG1554	hydrolase, family 65, central catalytic
D0819_13280	COG5521	maltodextrose utilization protein MalA
D0819_13285	COG3833	ABC-type maltose transport systems, permease component
D0819_13290	COG1175	transmembrane transport
D0819_13295	COG2182	Extracellular solute-binding protein
D0819_13300	COG0366	Alpha amylase catalytic
D0819_13305	COG1609	Transcriptional regulator
D0819_13310	COG1611	Belongs to the LOG family
D0819_13315	COG1694	Mazg nucleotide pyrophosphohydrolase
D0819_13320	COG0659	secondary active sulfate transmembrane transporter activity
D0819_13325	COG0288	reversible hydration of carbon dioxide
D0819_13330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D0819_13335	COG0577	efflux transmembrane transporter activity
D0819_13340	COG1136	(ABC) transporter
D0819_13345	COG5002	protein histidine kinase activity
D0819_13350	COG0745	RESPONSE REGULATOR receiver
D0819_13360	COG2162	N-hydroxyarylamine O-acetyltransferase activity
D0819_13365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0819_13370	COG1481	regulation of sporulation
D0819_13375	COG0391	Required for morphogenesis under gluconeogenic growth conditions
D0819_13380	COG1660	Displays ATPase and GTPase activities
D0819_13385	COG1051	belongs to the nudix hydrolase family
D0819_13390	COG0492	ferredoxin-NADP+ reductase activity
D0819_13395	COG0791	NLP P60 protein
D0819_13395	COG3883	PFAM NLP P60 protein
D0819_13400	COG0457	Tetratricopeptide repeat
D0819_13405	COG1132	(ABC) transporter
D0819_13425	COG0140	phosphoribosyl-ATP diphosphatase activity
D0819_13425	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D0819_13430	COG0107	imidazoleglycerol-phosphate synthase activity
D0819_13435	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D0819_13440	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D0819_13445	COG0131	Imidazoleglycerol-phosphate dehydratase
D0819_13450	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D0819_13455	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
D0819_13460	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
D0819_13465	COG4990	cell redox homeostasis
D0819_13470	COG5297	Belongs to the glycosyl hydrolase family 6
D0819_13475	COG0110	maltose O-acetyltransferase activity
D0819_13480	COG0546	phosphoglycolate phosphatase activity
D0819_13490	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
D0819_13495	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
D0819_13500	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
D0819_13505	COG0363	glucosamine-6-phosphate deaminase activity
D0819_13515	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D0819_13520	COG1846	Transcriptional regulator
D0819_13525	COG2124	cytochrome p450
D0819_13535	COG1846	Transcriptional regulator
D0819_13540	COG2814	Major facilitator Superfamily
D0819_13545	COG1950	PFAM Membrane protein of
D0819_13550	COG1983	PspC domain protein
D0819_13555	COG3595	metallopeptidase activity
D0819_13570	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0819_13575	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D0819_13580	COG0556	nucleotide-excision repair
D0819_13585	COG4897	Protein conserved in bacteria
D0819_13590	COG0574	Belongs to the PEP-utilizing enzyme family
D0819_13590	COG3848	Pyruvate phosphate dikinase
D0819_13595	COG1309	transcriptional regulator
D0819_13600	COG2814	Major facilitator Superfamily
D0819_13605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0819_13615	COG3409	Peptidoglycan-binding domain 1 protein
D0819_13615	COG0793	Belongs to the peptidase S41A family
D0819_13620	COG2177	Part of the ABC transporter FtsEX involved in
D0819_13625	COG2884	Cell division ATP-binding protein ftsE
D0819_13630	COG2010	Cytochrome c
D0819_13635	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D0819_13645	COG0653	protein targeting
D0819_13650	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
D0819_13665	COG1516	flagellar protein fliS
D0819_13670	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D0819_13675	COG1334	flagellar protein FlaG
D0819_13680	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0819_13685	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D0819_13690	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
D0819_13700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D0819_13705	COG1256	bacterial-type flagellum assembly
D0819_13705	COG4786	Flagellar basal body rod
D0819_13710	COG3418	PFAM FlgN family protein
D0819_13715	COG2747	anti-sigma28 factor FlgM
D0819_13725	COG1040	competence protein
D0819_13735	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
D0819_13740	COG1307	EDD domain protein, DegV family
D0819_13745	COG2197	response regulator
D0819_13750	COG4585	Histidine kinase
D0819_13755	COG1739	Uncharacterized protein family UPF0029
D0819_13760	COG1316	TRANSCRIPTIONal
D0819_13765	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D0819_13770	COG0438	transferase activity, transferring glycosyl groups
D0819_13775	COG1215	transferase activity, transferring glycosyl groups
D0819_13780	COG3206	protein involved in exopolysaccharide biosynthesis
D0819_13785	COG3307	-O-antigen
D0819_13790	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D0819_13795	COG0297	glycogen (starch) synthase activity
D0819_13795	COG0438	transferase activity, transferring glycosyl groups
D0819_13800	COG2244	polysaccharide biosynthetic process
D0819_13815	COG2247	cell wall binding repeat
D0819_13815	COG0860	N-Acetylmuramoyl-L-alanine amidase
D0819_13820	COG2247	cell wall binding repeat
D0819_13820	COG2385	sporulation resulting in formation of a cellular spore
D0819_13830	COG1316	TRANSCRIPTIONal
D0819_13835	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D0819_13855	COG1210	Utp--glucose-1-phosphate uridylyltransferase
D0819_13860	COG1134	teichoic acid transport
D0819_13865	COG1682	transport, permease protein
D0819_13870	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
D0819_13875	COG1442	glycosyl transferase family 8
D0819_13875	COG1216	Glycosyl transferase, family 2
D0819_13915	COG4193	domain, Protein
D0819_13920	COG1482	cell wall glycoprotein biosynthetic process
D0819_13925	COG0697	spore germination
D0819_13930	COG0814	amino acid
D0819_13940	COG2814	Major facilitator Superfamily
D0819_13945	COG1316	TRANSCRIPTIONal
D0819_13950	COG0561	phosphatase activity
D0819_13955	COG0791	NLP P60 protein
D0819_13965	COG2843	Capsule synthesis protein
D0819_13975	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D0819_13980	COG1609	Transcriptional regulator
D0819_13985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0819_13990	COG1869	D-ribose catabolic process
D0819_13995	COG1129	ABC transporter
D0819_14000	COG1172	Belongs to the binding-protein-dependent transport system permease family
D0819_14005	COG1879	ABC-type sugar transport system periplasmic component
D0819_14010	COG3103	Sh3 type 3 domain protein
D0819_14020	COG2249	NAD(P)H dehydrogenase (quinone) activity
D0819_14025	COG3527	Alpha-acetolactate decarboxylase
D0819_14030	COG0028	Belongs to the TPP enzyme family
D0819_14035	COG0583	DNA-binding transcription factor activity
D0819_14040	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D0819_14055	COG5337	Spore coat protein CotH
D0819_14065	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D0819_14075	COG0405	Gamma-glutamyltransferase
D0819_14080	COG1522	sequence-specific DNA binding
D0819_14085	COG2059	Chromate
D0819_14090	COG2059	Chromate
D0819_14100	COG0655	NAD(P)H dehydrogenase (quinone) activity
D0819_14105	COG0583	DNA-binding transcription factor activity
D0819_14110	COG1515	deoxyribonuclease V activity
D0819_14125	COG5444	nuclease activity
D0819_14145	COG3878	Protein conserved in bacteria
D0819_14150	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
D0819_14155	COG4464	protein tyrosine phosphatase activity
D0819_14160	COG0489	protein tyrosine kinase activity
D0819_14165	COG3944	biosynthesis protein
D0819_14175	COG4715	Zinc finger, swim domain protein
D0819_14180	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
D0819_14185	COG0561	phosphatase activity
D0819_14190	COG1349	DNA-binding transcription factor activity
D0819_14195	COG0629	single-stranded DNA binding
D0819_14210	COG3764	Sortase (surface protein transpeptidase)
D0819_14220	COG3279	Response regulator of the LytR AlgR family
D0819_14225	COG0745	RESPONSE REGULATOR receiver
D0819_14225	COG2972	Histidine kinase
D0819_14230	COG1970	mechanosensitive ion channel activity
D0819_14235	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D0819_14240	COG0457	Tetratricopeptide repeat
D0819_14245	COG4786	Flagellar basal body rod
D0819_14250	COG4786	Flagellar basal body rod
D0819_14255	COG1077	Cell shape determining protein MreB Mrl
D0819_14260	COG1609	Transcriptional regulator
D0819_14270	COG1846	Transcriptional regulator
D0819_14275	COG2814	Major facilitator Superfamily
D0819_14280	COG3420	alginic acid biosynthetic process
D0819_14285	COG1953	Uracil, thiamine, allantoin
D0819_14290	COG0477	Major facilitator Superfamily
D0819_14295	COG1335	isochorismatase
D0819_14305	COG0004	ammonium transporteR
D0819_14310	COG0347	Belongs to the P(II) protein family
D0819_14315	COG0671	phosphoesterase, PA-phosphatase related
D0819_14325	COG0739	heme binding
D0819_14330	COG1247	-acetyltransferase
D0819_14345	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0819_14350	COG0789	Transcriptional regulator
D0819_14360	COG2910	NAD(P)H-binding
D0819_14365	COG1959	2 iron, 2 sulfur cluster binding
D0819_14370	COG0804	urea catabolic process
D0819_14375	COG0832	Belongs to the urease beta subunit family
D0819_14380	COG0831	urea catabolic process
D0819_14395	COG3237	CsbD-like
D0819_14400	COG1994	Peptidase M50
D0819_14405	COG0457	Tetratricopeptide repeat
D0819_14410	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D0819_14415	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D0819_14425	COG2304	oxidoreductase activity
D0819_14435	COG2304	oxidoreductase activity
D0819_14440	COG2385	sporulation resulting in formation of a cellular spore
D0819_14445	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D0819_14455	COG4836	Membrane
D0819_14465	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D0819_14470	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D0819_14475	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
D0819_14480	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D0819_14485	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D0819_14490	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D0819_14495	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D0819_14500	COG0356	it plays a direct role in the translocation of protons across the membrane
D0819_14510	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D0819_14515	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D0819_14520	COG4475	Protein of unknown function (DUF436)
D0819_14525	COG0698	ribose 5-phosphate isomerase
D0819_14530	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D0819_14535	COG1971	Probably functions as a manganese efflux pump
D0819_14540	COG0009	L-threonylcarbamoyladenylate synthase
D0819_14545	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
D0819_14565	COG2890	protein-(glutamine-N5) methyltransferase activity
D0819_14570	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D0819_14575	COG0346	lactoylglutathione lyase activity
D0819_14580	COG0789	Transcriptional regulator
D0819_14585	COG0679	Auxin Efflux Carrier
D0819_14590	COG0281	malic enzyme
D0819_14595	COG1435	thymidine kinase activity
D0819_14600	COG0254	rRNA binding
D0819_14605	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D0819_14610	COG1494	fructose-1,6-bisphosphatase
D0819_14615	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
D0819_14620	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
D0819_14625	COG0191	fructose-bisphosphate aldolase activity
D0819_14630	COG2204	response regulator
D0819_14635	COG4821	SIS domain
D0819_14640	COG0504	CTP synthase activity
D0819_14645	COG3343	RNA polymerase activity
D0819_14650	COG1960	acyl-CoA dehydrogenase activity
D0819_14655	COG0247	lactate metabolic process
D0819_14655	COG2181	nitrate reductase activity
D0819_14660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0819_14665	COG4294	response to UV
D0819_14675	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D0819_14680	COG1132	(ABC) transporter
D0819_14685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
D0819_14695	COG2181	nitrate reductase activity
D0819_14700	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
D0819_14705	COG1140	nitrate reductase beta subunit
D0819_14710	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
D0819_14715	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0819_14725	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
D0819_14730	COG2223	nitrite transmembrane transporter activity
D0819_14735	COG0018	arginyl-trna synthetase
D0819_14740	COG4506	Protein conserved in bacteria
D0819_14755	COG0535	radical SAM domain protein
D0819_14765	COG1131	(ABC) transporter
D0819_14770	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
D0819_14775	COG0612	Peptidase, M16
D0819_14780	COG0612	Peptidase, M16
D0819_14790	COG3391	amine dehydrogenase activity
D0819_14795	COG3391	amine dehydrogenase activity
D0819_14805	COG0457	Tetratricopeptide repeat
D0819_14835	COG1131	(ABC) transporter
D0819_14845	COG0010	Belongs to the arginase family
D0819_14850	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
D0819_14855	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
D0819_14870	COG1994	Peptidase M50
D0819_14875	COG1942	4-Oxalocrotonate Tautomerase
D0819_14880	COG1846	Transcriptional regulator
D0819_14885	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D0819_14890	COG0477	Major facilitator Superfamily
D0819_14895	COG1959	2 iron, 2 sulfur cluster binding
D0819_14900	COG3465	dGTPase activity
D0819_14905	COG1078	dGTPase activity
D0819_14910	COG4844	belongs to the
D0819_14920	COG0697	spore germination
D0819_14930	COG0095	Lipoate-protein ligase
D0819_14935	COG0583	DNA-binding transcription factor activity
D0819_14940	COG0280	phosphate acetyltransferase
D0819_14950	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_14955	COG0436	Aminotransferase
D0819_14960	COG2814	Major facilitator Superfamily
D0819_14965	COG0151	Belongs to the GarS family
D0819_14970	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_14975	COG1917	Cupin 2, conserved barrel domain protein
D0819_14980	COG0077	Prephenate dehydratase
D0819_14985	COG2814	Major facilitator Superfamily
D0819_14990	COG0833	amino acid
D0819_14995	COG4187	Peptidase family M20/M25/M40
D0819_15000	COG1012	belongs to the aldehyde dehydrogenase family
D0819_15005	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
D0819_15015	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
D0819_15020	COG1091	dTDP-4-dehydrorhamnose reductase activity
D0819_15025	COG1088	dTDP-glucose 4,6-dehydratase activity
D0819_15030	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
D0819_15035	COG3980	spore coat polysaccharide biosynthesis protein
D0819_15040	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
D0819_15045	COG2089	acid synthase
D0819_15050	COG0456	acetyltransferase
D0819_15055	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D0819_15060	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
D0819_15065	COG0463	Glycosyl transferase, family 2
D0819_15080	COG2363	Small membrane protein
D0819_15085	COG2233	PERMEase
D0819_15095	COG1012	belongs to the aldehyde dehydrogenase family
D0819_15100	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
D0819_15105	COG1216	Glycosyl transferase, family 2
D0819_15110	COG0351	phosphomethylpyrimidine kinase
D0819_15120	COG1621	beta-fructofuranosidase activity
D0819_15125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0819_15125	COG1263	PTS System
D0819_15130	COG2116	formate transmembrane transporter activity
D0819_15135	COG3711	transcriptional antiterminator
D0819_15145	COG1404	Belongs to the peptidase S8 family
D0819_15150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0819_15155	COG0778	Nitroreductase
D0819_15160	COG0772	Belongs to the SEDS family
D0819_15170	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D0819_15175	COG1845	cytochrome c oxidase, subunit III
D0819_15180	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D0819_15185	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D0819_15190	COG2261	transglycosylase associated protein
D0819_15195	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
D0819_15200	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
D0819_15205	COG2246	polysaccharide biosynthetic process
D0819_15210	COG1309	transcriptional regulator
D0819_15220	COG3162	membrane
D0819_15225	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0819_15230	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D0819_15235	COG2837	iron assimilation
D0819_15240	COG2822	iron ion transport
D0819_15245	COG0672	)-iron permease
D0819_15250	COG0352	thiamine-phosphate diphosphorylase activity
D0819_15255	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
D0819_15260	COG0583	DNA-binding transcription factor activity
D0819_15265	COG1380	Effector of murein hydrolase LrgA
D0819_15270	COG1346	cytolysis
D0819_15275	COG2814	Major facilitator Superfamily
D0819_15280	COG4895	conserved protein (DUF2196)
D0819_15285	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
D0819_15290	COG0346	lactoylglutathione lyase activity
D0819_15300	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0819_15305	COG1404	Belongs to the peptidase S8 family
D0819_15310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0819_15310	COG1263	PTS System
D0819_15315	COG3711	transcriptional antiterminator
D0819_15320	COG1442	glycosyl transferase family 8
D0819_15325	COG5522	Integral membrane protein (intg_mem_TP0381)
D0819_15330	COG1846	Transcriptional regulator
D0819_15335	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
D0819_15340	COG2234	aminopeptidase activity
D0819_15345	COG2357	RelA SpoT domain protein
D0819_15350	COG1575	Belongs to the MenA family. Type 1 subfamily
D0819_15365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0819_15370	COG1696	Membrane protein involved in D-alanine export
D0819_15375	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D0819_15380	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
D0819_15385	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
D0819_15390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D0819_15395	COG1486	melibiose metabolic process
D0819_15400	COG1447	Phosphotransferase system cellobiose-specific component IIA
D0819_15405	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0819_15410	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0819_15415	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0819_15415	COG3711	transcriptional antiterminator
D0819_15425	COG2094	Belongs to the DNA glycosylase MPG family
D0819_15430	COG0753	catalase activity
D0819_15435	COG2814	Major facilitator Superfamily
D0819_15440	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D0819_15445	COG1131	(ABC) transporter
D0819_15465	COG1595	DNA-templated transcription, initiation
D0819_15470	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D0819_15475	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
D0819_15480	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
D0819_15485	COG4988	ABC transporter
D0819_15490	COG1294	oxidase, subunit
D0819_15495	COG1271	oxidase subunit
D0819_15500	COG3493	citrate carrier protein
D0819_15505	COG0501	Belongs to the peptidase M48B family
D0819_15515	COG0726	polysaccharide deacetylase
D0819_15520	COG3842	ATPase activity
D0819_15525	COG2508	Transcriptional regulator
D0819_15530	COG1012	belongs to the aldehyde dehydrogenase family
D0819_15535	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D0819_15550	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D0819_15555	COG1881	PFAM PEBP family protein
D0819_15560	COG0583	DNA-binding transcription factor activity
D0819_15570	COG4585	Histidine kinase
D0819_15575	COG2197	response regulator
D0819_15580	COG2195	Cleaves the N-terminal amino acid of tripeptides
D0819_15590	COG4894	glucomannan catabolic process
D0819_15595	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D0819_15600	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D0819_15605	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_15610	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
D0819_15615	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
D0819_15620	COG2610	gluconate transmembrane transporter activity
D0819_15625	COG0500	methyltransferase
D0819_15630	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D0819_15645	COG0753	catalase activity
D0819_15645	COG0693	protein deglycase activity
D0819_15650	COG2851	Citrate transporter
D0819_15655	COG2273	Hydrolase Family 16
D0819_15660	COG3711	transcriptional antiterminator
D0819_15670	COG2270	Major facilitator Superfamily
D0819_15675	COG0513	Belongs to the DEAD box helicase family
D0819_15680	COG2755	lipolytic protein G-D-S-L family
D0819_15680	COG3401	FG-GAP repeat protein
D0819_15745	COG0697	spore germination
D0819_15760	COG0589	response to stress
D0819_15765	COG2723	6-phospho-beta-galactosidase activity
D0819_15770	COG1263	PTS System
D0819_15770	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0819_15770	COG2190	(PTS) system
D0819_15785	COG5444	nuclease activity
D0819_15820	COG3507	Belongs to the glycosyl hydrolase 43 family
D0819_15835	COG2986	histidine ammonia-lyase
D0819_15840	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
D0819_15845	COG1228	amidohydrolase
D0819_15850	COG0010	Belongs to the arginase family
D0819_15855	COG0833	amino acid
D0819_15860	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
D0819_15865	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
D0819_15870	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
D0819_15875	COG2390	Transcriptional regulator
D0819_15885	COG3192	ethanolamine utilization protein
D0819_15890	COG2079	MmgE PrpD family protein
D0819_15900	COG1126	abc transporter atp-binding protein
D0819_15905	COG0765	amino acid transport
D0819_15910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0819_15930	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
D0819_15935	COG0561	phosphatase activity
D0819_15965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D0819_15970	COG5294	Protein conserved in bacteria
D0819_15975	COG0577	efflux transmembrane transporter activity
D0819_15980	COG1136	(ABC) transporter
D0819_15985	COG2205	protein histidine kinase activity
D0819_15990	COG0745	RESPONSE REGULATOR receiver
D0819_15995	COG0191	fructose-bisphosphate aldolase activity
D0819_16000	COG1082	Xylose isomerase domain protein TIM barrel
D0819_16005	COG1082	Xylose isomerase domain protein TIM barrel
D0819_16010	COG0673	inositol 2-dehydrogenase activity
D0819_16015	COG2814	Major facilitator Superfamily
D0819_16020	COG1082	Xylose isomerase domain protein TIM barrel
D0819_16025	COG3962	Belongs to the TPP enzyme family
D0819_16030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0819_16040	COG1012	belongs to the aldehyde dehydrogenase family
D0819_16045	COG1349	DNA-binding transcription factor activity
D0819_16050	COG0667	Aldo Keto reductase
D0819_16080	COG2814	Major facilitator Superfamily
D0819_16085	COG0326	Molecular chaperone. Has ATPase activity
D0819_16095	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_16100	COG1309	transcriptional regulator
D0819_16105	COG1012	belongs to the aldehyde dehydrogenase family
D0819_16115	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D0819_16125	COG1714	RDD family
D0819_16130	COG2311	Membrane
D0819_16135	COG1917	Cupin 2, conserved barrel domain protein
D0819_16140	COG1309	transcriptional regulator
D0819_16145	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_16150	COG1846	Transcriptional regulator
D0819_16155	COG1380	Effector of murein hydrolase LrgA
D0819_16160	COG1346	cytolysis
D0819_16165	COG5039	Polysaccharide pyruvyl transferase
D0819_16170	COG1929	Belongs to the glycerate kinase type-1 family
D0819_16175	COG1802	Transcriptional regulator
D0819_16180	COG1070	Carbohydrate kinase
D0819_16185	COG2610	gluconate transmembrane transporter activity
D0819_16190	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D0819_16195	COG0450	alkyl hydroperoxide reductase
D0819_16200	COG3634	alkyl hydroperoxide reductase activity
D0819_16210	COG2723	6-phospho-beta-galactosidase activity
D0819_16225	COG2188	Transcriptional regulator
D0819_16240	COG1131	(ABC) transporter
D0819_16245	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
D0819_16255	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
D0819_16270	COG1063	alcohol dehydrogenase
D0819_16295	COG0456	acetyltransferase
D0819_16300	COG0457	Tetratricopeptide repeat
D0819_16310	COG0010	Belongs to the arginase family
D0819_16315	COG0833	amino acid
D0819_16320	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D0819_16325	COG3829	transcription factor binding
D0819_16335	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D0819_16340	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
D0819_16345	COG4853	Protein conserved in bacteria
D0819_16350	COG4863	YycH protein
D0819_16355	COG5002	protein histidine kinase activity
D0819_16360	COG0745	RESPONSE REGULATOR receiver
D0819_16390	COG0346	lactoylglutathione lyase activity
D0819_16395	COG0305	Participates in initiation and elongation during chromosome replication
D0819_16410	COG3093	addiction module antidote protein HigA
D0819_16415	COG2807	transmembrane transport
D0819_16420	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
D0819_16425	COG0359	binds to the 23S rRNA
D0819_16430	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
D0819_16435	COG4241	membrane
D0819_16445	COG5577	PFAM Coat F domain
D0819_16450	COG1733	regulation of RNA biosynthetic process
D0819_16455	COG1227	inorganic diphosphatase activity
D0819_16470	COG2271	Major facilitator Superfamily
D0819_16475	COG0789	Transcriptional regulator
D0819_16475	COG4978	Transcriptional regulator
D0819_16485	COG4319	ketosteroid isomerase
D0819_16490	COG1357	PFAM Pentapeptide repeats (8 copies)
D0819_16495	COG2814	Major facilitator Superfamily
D0819_16500	COG0583	DNA-binding transcription factor activity
D0819_16505	COG2153	protein acetylation
D0819_16520	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0819_16525	COG1846	Transcriptional regulator
D0819_16530	COG2153	protein acetylation
D0819_16535	COG2364	Membrane
D0819_16540	COG0456	acetyltransferase
D0819_16545	COG2315	Protein conserved in bacteria
D0819_16550	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
D0819_16580	COG1331	Highly conserved protein containing a thioredoxin domain
D0819_16585	COG1266	CAAX protease self-immunity
D0819_16590	COG2814	Major facilitator Superfamily
D0819_16590	COG0477	Major facilitator Superfamily
D0819_16595	COG0110	maltose O-acetyltransferase activity
D0819_16600	COG0346	lactoylglutathione lyase activity
D0819_16605	COG1609	Transcriptional regulator
D0819_16610	COG0708	Exodeoxyribonuclease III
D0819_16615	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D0819_16620	COG0629	single-stranded DNA binding
D0819_16625	COG0360	Binds together with S18 to 16S ribosomal RNA
D0819_16630	COG0012	GTP binding
D0819_16635	COG0243	molybdopterin cofactor binding
D0819_16640	COG4481	Protein conserved in bacteria
D0819_16645	COG3949	Membrane
D0819_16655	COG1475	DNA binding
D0819_16660	COG1192	Involved in chromosome partitioning
D0819_16670	COG1475	DNA binding
D0819_16675	COG0357	Ribosomal RNA small subunit methyltransferase G
D0819_16680	COG0445	tRNA wobble uridine modification
D0819_16685	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D0819_16690	COG1847	R3H domain protein
D0819_16695	COG0706	membrane insertase activity
D0819_16700	COG0594	ribonuclease P activity
D0819_16705	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D0819_16710	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D0819_16715	COG0592	DNA-directed DNA polymerase activity
D0819_16720	COG2501	S4 domain
D0819_16725	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
D0819_16735	COG0187	DNA topoisomerase II activity
D0819_16740	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D0819_16765	COG0517	IMP dehydrogenase activity
D0819_16765	COG0516	GMP reductase activity
D0819_16770	COG1686	Belongs to the peptidase S11 family
D0819_16775	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D0819_16780	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D0819_16785	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D0819_16795	COG1428	Deoxynucleoside kinase
D0819_16800	COG1428	Deoxynucleoside kinase
D0819_16805	COG1388	LysM domain
D0819_16805	COG3858	chitin binding
D0819_16810	COG1335	isochorismatase
D0819_16815	COG0590	tRNA wobble adenosine to inosine editing
D0819_16825	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D0819_16830	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D0819_16835	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D0819_16870	COG0517	IMP dehydrogenase activity
D0819_16870	COG0516	GMP reductase activity
D0819_16875	COG1686	Belongs to the peptidase S11 family
D0819_16880	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D0819_16885	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D0819_16890	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D0819_16900	COG1428	Deoxynucleoside kinase
D0819_16905	COG1428	Deoxynucleoside kinase
D0819_16910	COG3858	chitin binding
D0819_16910	COG1388	LysM domain
D0819_16915	COG1335	isochorismatase
D0819_16920	COG0590	tRNA wobble adenosine to inosine editing
D0819_16930	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D0819_16935	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D0819_16940	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D0819_17035	COG0516	GMP reductase activity
D0819_17035	COG0517	IMP dehydrogenase activity
D0819_17040	COG1686	Belongs to the peptidase S11 family
D0819_17045	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
D0819_17050	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
D0819_17055	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
D0819_17065	COG1428	Deoxynucleoside kinase
D0819_17070	COG1428	Deoxynucleoside kinase
D0819_17075	COG1388	LysM domain
D0819_17075	COG3858	chitin binding
D0819_17080	COG1335	isochorismatase
D0819_17085	COG0590	tRNA wobble adenosine to inosine editing
D0819_17095	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D0819_17100	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D0819_17105	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D0819_17140	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
D0819_17145	COG3853	Toxic anion resistance protein (TelA)
D0819_17150	COG1982	Orn Lys Arg decarboxylase major
D0819_17155	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D0819_17160	COG3870	Protein conserved in bacteria
D0819_17165	COG1728	Protein conserved in bacteria
D0819_17170	COG0470	DNA polymerase III
D0819_17175	COG1774	PSP1 C-terminal conserved region
D0819_17180	COG4467	Involved in initiation control of chromosome replication
D0819_17185	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
D0819_17190	COG2827	Endonuclease containing a URI domain
D0819_17195	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D0819_17200	COG2002	toxin-antitoxin pair type II binding
D0819_17205	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0819_17205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D0819_17210	COG0084	hydrolase, TatD family'
D0819_17215	COG3583	domain protein
D0819_17215	COG3584	3D domain protein
D0819_17220	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
D0819_17225	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D0819_17235	COG4466	Protein conserved in bacteria
D0819_17245	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
D0819_17250	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
D0819_17255	COG0251	oxidation-reduction process
D0819_17260	COG2088	sporulation resulting in formation of a cellular spore
D0819_17265	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D0819_17270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D0819_17275	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D0819_17280	COG0193	aminoacyl-tRNA hydrolase activity
D0819_17290	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D0819_17295	COG2002	toxin-antitoxin pair type II binding
D0819_17300	COG2244	polysaccharide biosynthetic process
D0819_17305	COG3956	TIGRFAM MazG family protein
D0819_17310	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D0819_17325	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
D0819_17330	COG1098	S1 RNA binding domain
D0819_17345	COG2208	phosphoserine phosphatase activity
D0819_17350	COG2304	oxidoreductase activity
D0819_17355	COG0515	serine threonine protein kinase
D0819_17360	COG0037	tRNA processing
D0819_17370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D0819_17375	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D0819_17380	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
D0819_17385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D0819_17390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D0819_17395	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D0819_17400	COG0512	Glutamine amidotransferase of anthranilate synthase
D0819_17405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D0819_17410	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D0819_17415	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
D0819_17420	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D0819_17425	COG1396	sequence-specific DNA binding
D0819_17430	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0819_17435	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D0819_17515	COG4463	regulation of RNA biosynthetic process
D0819_17520	COG3880	PFAM UvrB UvrC protein
D0819_17525	COG3869	Catalyzes the specific phosphorylation of arginine residues in
D0819_17530	COG0542	response to heat
D0819_17535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D0819_17540	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
D0819_17545	COG4956	integral membrane protein (PIN domain superfamily)
D0819_17550	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D0819_17555	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D0819_17560	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D0819_17570	COG1045	serine acetyltransferase
D0819_17575	COG0215	cysteine-tRNA ligase activity
D0819_17580	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
D0819_17585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D0819_17590	COG3688	RNA-binding protein containing a PIN domain
D0819_17595	COG1595	DNA-templated transcription, initiation
D0819_17600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D0819_17605	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D0819_17610	COG0250	Participates in transcription elongation, termination and antitermination
D0819_17615	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D0819_17620	COG0081	regulation of translation
D0819_17625	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D0819_17630	COG0222	ribosome binding
D0819_17635	COG2813	Specifically methylates the guanine in position
D0819_17640	COG0085	RNA polymerase activity
D0819_17645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D0819_17650	COG1358	cellular component organization or biogenesis
D0819_17655	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D0819_17660	COG0049	tRNA binding
D0819_17665	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
D0819_17670	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D0819_17675	COG0596	Alpha beta hydrolase
D0819_17680	COG0051	transcription antitermination factor activity, RNA binding
D0819_17685	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D0819_17690	COG0088	Forms part of the polypeptide exit tunnel
D0819_17695	COG0089	rRNA binding
D0819_17700	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D0819_17705	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D0819_17710	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D0819_17715	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D0819_17720	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D0819_17725	COG0255	Belongs to the universal ribosomal protein uL29 family
D0819_17730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D0819_17735	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D0819_17745	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D0819_17755	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D0819_17760	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D0819_17765	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D0819_17770	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D0819_17775	COG1841	ribosomal large subunit assembly
D0819_17780	COG0200	Binds to the 23S rRNA
D0819_17785	COG0201	protein transport
D0819_17790	COG0563	adenylate kinase activity
D0819_17795	COG0024	Methionine aminopeptidase
D0819_17800	COG2163	COG2163 Ribosomal protein L14E L6E L27E
D0819_17805	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D0819_17810	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D0819_17815	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D0819_17820	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D0819_17825	COG0202	RNA polymerase activity
D0819_17830	COG0203	ribosomal protein L17
D0819_17835	COG1122	ATPase activity
D0819_17840	COG1122	ATPase activity
D0819_17845	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
D0819_17850	COG0101	tRNA pseudouridine synthase activity
D0819_17855	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D0819_17860	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D0819_17865	COG2226	methyltransferase
D0819_17875	COG0860	N-Acetylmuramoyl-L-alanine amidase
D0819_17880	COG0489	protein tyrosine kinase activity
D0819_17890	COG2194	sulfuric ester hydrolase activity
D0819_17895	COG0726	polysaccharide deacetylase
D0819_17965	COG0659	secondary active sulfate transmembrane transporter activity
D0819_17970	COG0385	Bile acid
D0819_17980	COG2746	aminoglycoside 3-N-acetyltransferase activity
D0819_17985	COG0747	negative chemotaxis
D0819_17995	COG1136	(ABC) transporter
D0819_18000	COG2814	Major facilitator Superfamily
D0819_18010	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0819_18015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0819_18020	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D0819_18025	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D0819_18025	COG2207	Transcriptional regulator
D0819_18030	COG3876	Protein conserved in bacteria
D0819_18035	COG1472	Belongs to the glycosyl hydrolase 3 family
D0819_18040	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
D0819_18045	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0819_18045	COG1263	PTS System
D0819_18050	COG1737	Transcriptional regulator
D0819_18055	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
D0819_18060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0819_18065	COG1683	Conserved Protein
D0819_18095	COG1595	DNA-templated transcription, initiation
D0819_18100	COG5662	AntiSigma factor
D0819_18105	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
D0819_18110	COG4856	YbbR-like protein
D0819_18115	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
D0819_18120	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D0819_18125	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D0819_18130	COG3002	Belongs to the UPF0753 family
D0819_18135	COG0288	reversible hydration of carbon dioxide
D0819_18145	COG5609	conserved protein (DUF2294)
D0819_18150	COG0640	Transcriptional regulator
D0819_18155	COG2814	Major facilitator Superfamily
D0819_18170	COG0515	serine threonine protein kinase
D0819_18185	COG1113	amino acid transport
D0819_18200	COG2602	Beta-lactamase
D0819_18205	COG2124	cytochrome p450
D0819_18215	COG0531	amino acid
D0819_18220	COG0584	glycerophosphoryl diester phosphodiesterase
D0819_18225	COG2271	Major facilitator Superfamily
D0819_18240	COG0456	acetyltransferase
D0819_18240	COG1846	Transcriptional regulator
D0819_18245	COG2271	Major facilitator Superfamily
D0819_18260	COG3409	Peptidoglycan-binding domain 1 protein
D0819_18265	COG0697	spore germination
D0819_18270	COG1917	Cupin 2, conserved barrel domain protein
D0819_18270	COG2207	Transcriptional regulator
D0819_18275	COG1397	ADP-ribosylglycohydrolase
D0819_18280	COG5444	nuclease activity
D0819_18285	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
D0819_18290	COG3591	Belongs to the peptidase S1B family
D0819_18300	COG0596	Alpha beta hydrolase
D0819_18305	COG1183	phosphatidylcholine synthase activity
D0819_18310	COG0586	Pfam SNARE associated Golgi protein
D0819_18315	COG0688	phosphatidylethanolamine metabolic process
D0819_18325	COG2312	Erythromycin esterase
D0819_18335	COG1301	dicarboxylic acid transport
D0819_18340	COG1263	PTS System
D0819_18340	COG2190	(PTS) system
D0819_18340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0819_18345	COG0363	glucosamine-6-phosphate deaminase activity
D0819_18360	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
D0819_18365	COG0833	amino acid
D0819_18370	COG2040	homocysteine
D0819_18380	COG1115	amino acid carrier protein
D0819_18385	COG2066	Belongs to the glutaminase family
D0819_18390	COG4191	Histidine kinase
D0819_18395	COG0784	Response regulator, receiver
D0819_18405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D0819_18410	COG1012	belongs to the aldehyde dehydrogenase family
D0819_18415	COG2271	Major facilitator Superfamily
D0819_18420	COG4948	Mandelate Racemase Muconate Lactonizing
D0819_18425	COG2186	Transcriptional regulator
D0819_18430	COG2721	sulfolactate sulfo-lyase activity
D0819_18435	COG3173	Aminoglycoside phosphotransferase
D0819_18445	COG0697	spore germination
D0819_18450	COG0745	RESPONSE REGULATOR receiver
D0819_18455	COG2205	protein histidine kinase activity
D0819_18460	COG1131	(ABC) transporter
D0819_18475	COG3773	Cell wall hydrolase
D0819_18480	COG2304	oxidoreductase activity
D0819_18490	COG3540	Alkaline phosphatase
D0819_18495	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D0819_18500	COG0805	protein transport
D0819_18505	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
D0819_18510	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D0819_18515	COG0477	Major facilitator Superfamily
D0819_18520	COG1309	transcriptional regulator
D0819_18525	COG0252	asparaginase activity
D0819_18530	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D0819_18535	COG1714	RDD family
D0819_18540	COG3012	SEC-C Motif Domain Protein
D0819_18540	COG1405	negative regulation of cell septum assembly
D0819_18545	COG3290	protein histidine kinase activity
D0819_18550	COG3279	Response regulator of the LytR AlgR family
D0819_18555	COG4555	ABC transporter
D0819_18560	COG1668	transmembrane transport
D0819_18565	COG0667	Aldo Keto reductase
D0819_18575	COG1595	DNA-templated transcription, initiation
D0819_18580	COG1595	DNA-templated transcription, initiation
D0819_18585	COG1876	peptidase activity
D0819_18590	COG0457	Tetratricopeptide repeat
D0819_18595	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_18605	COG0803	Belongs to the bacterial solute-binding protein 9 family
D0819_18610	COG1121	(ABC) transporter
D0819_18615	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D0819_18620	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0819_18625	COG2310	stress, protein
D0819_18630	COG2310	stress, protein
D0819_18635	COG2310	stress, protein
D0819_18640	COG0861	Integral membrane protein TerC family
D0819_18650	COG3853	Toxic anion resistance protein (TelA)
D0819_18655	COG0477	Major facilitator Superfamily
D0819_18665	COG2814	Major facilitator Superfamily
D0819_18670	COG0640	Transcriptional regulator
D0819_18675	COG4175	Glycine betaine
D0819_18675	COG0517	IMP dehydrogenase activity
D0819_18680	COG4176	ABC-type proline glycine betaine transport system permease component
D0819_18685	COG2113	Glycine betaine
D0819_18690	COG1473	amidohydrolase
D0819_18695	COG1288	antiporter activity
D0819_18705	COG0366	Alpha amylase catalytic
D0819_18710	COG0039	L-malate dehydrogenase activity
D0819_18715	COG1620	l-lactate permease
D0819_18720	COG2814	Major facilitator Superfamily
D0819_18725	COG1846	Transcriptional regulator
D0819_18730	COG1280	lysine exporter protein (LysE YggA)
D0819_18735	COG3403	YqcI/YcgG family
D0819_18740	COG1113	amino acid transport
D0819_18745	COG3665	Urea carboxylase-associated protein
D0819_18750	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D0819_18755	COG1660	Displays ATPase and GTPase activities
D0819_18760	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
D0819_18765	COG2226	methyltransferase
D0819_18770	COG0583	DNA-binding transcription factor activity
D0819_18775	COG3458	cephalosporin-C deacetylase activity
D0819_18780	COG3541	Predicted nucleotidyltransferase
D0819_18785	COG0506	proline dehydrogenase activity
D0819_18790	COG1012	belongs to the aldehyde dehydrogenase family
D0819_18795	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0819_18800	COG2508	Transcriptional regulator
D0819_18805	COG3689	TIGRFAM TIGR03943 family protein
D0819_18810	COG0701	Predicted permease
D0819_18815	COG2267	carboxylic ester hydrolase activity
D0819_18820	COG0492	ferredoxin-NADP+ reductase activity
D0819_18825	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
D0819_18825	COG1587	Uroporphyrinogen-III synthase
D0819_18830	COG2146	nitrite reductase [NAD(P)H] activity
D0819_18835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D0819_18840	COG0243	molybdopterin cofactor binding
D0819_18845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
D0819_18850	COG2223	nitrite transmembrane transporter activity
D0819_18855	COG1469	GTP cyclohydrolase I activity
D0819_18860	COG1376	ErfK ybiS ycfS ynhG family protein
D0819_18870	COG0523	cobalamin synthesis protein
D0819_18875	COG0765	amino acid transport
D0819_18880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0819_18895	COG1846	Transcriptional regulator
D0819_18905	COG3842	ATPase activity
D0819_18910	COG2723	6-phospho-beta-galactosidase activity
D0819_18920	COG3209	COG3209 Rhs family protein
D0819_18925	COG0840	transmembrane signaling receptor activity
D0819_18925	COG3290	protein histidine kinase activity
D0819_18930	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D0819_18935	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
D0819_18940	COG1733	regulation of RNA biosynthetic process
D0819_18945	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0819_18950	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0819_18955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
D0819_18960	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
D0819_18965	COG2814	Major facilitator Superfamily
D0819_18975	COG0697	spore germination
D0819_18980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0819_18990	COG2364	Membrane
D0819_18995	COG1126	abc transporter atp-binding protein
D0819_19000	COG0765	amino acid transport
D0819_19005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D0819_19010	COG0583	DNA-binding transcription factor activity
D0819_19015	COG0163	prenyltransferase activity
D0819_19020	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D0819_19035	COG0596	Alpha beta hydrolase
D0819_19040	COG3104	oligopeptide transport
D0819_19045	COG5434	Belongs to the glycosyl hydrolase 28 family
D0819_19055	COG0697	spore germination
D0819_19065	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
D0819_19070	COG1136	(ABC) transporter
D0819_19075	COG0577	efflux transmembrane transporter activity
D0819_19080	COG0745	RESPONSE REGULATOR receiver
D0819_19085	COG3850	Histidine kinase
D0819_19085	COG5002	protein histidine kinase activity
D0819_19090	COG0457	Tetratricopeptide repeat
D0819_19110	COG0527	aspartate kinase activity
D0819_19115	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0819_19120	COG4605	iron ion homeostasis
D0819_19125	COG4604	ABC transporter, ATP-binding protein
D0819_19130	COG4607	ABC-type enterochelin transport system periplasmic component
D0819_19135	COG2814	Major facilitator Superfamily
D0819_19140	COG1309	transcriptional regulator
D0819_19145	COG0778	Nitroreductase
D0819_19150	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
D0819_19155	COG0640	Transcriptional regulator
D0819_19160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0819_19165	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
D0819_19170	COG1012	belongs to the aldehyde dehydrogenase family
D0819_19175	COG4975	Glucose uptake
D0819_19180	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_19185	COG4549	nuclear export factor GLE1
D0819_19190	COG2372	response to copper ion
D0819_19190	COG1276	copper resistance
D0819_19195	COG1349	DNA-binding transcription factor activity
D0819_19205	COG2213	PTS system mannitol-specific
D0819_19210	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
D0819_19215	COG0246	Mannitol dehydrogenase
D0819_19220	COG0473	3-isopropylmalate dehydrogenase activity
D0819_19225	COG0681	Belongs to the peptidase S26 family
D0819_19230	COG0412	Dienelactone hydrolase
D0819_19235	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D0819_19245	COG0561	phosphatase activity
D0819_19250	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D0819_19255	COG1914	H( )-stimulated, divalent metal cation uptake system
D0819_19260	COG4336	lyase activity
D0819_19265	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D0819_19270	COG1984	allophanate hydrolase subunit 2
D0819_19275	COG1414	Transcriptional regulator
D0819_19280	COG2755	lipolytic protein G-D-S-L family
D0819_19290	COG2329	Antibiotic biosynthesis monooxygenase
D0819_19295	COG0768	penicillin binding
D0819_19300	COG4989	oxidoreductase activity
D0819_19305	COG3711	transcriptional antiterminator
D0819_19310	COG0318	PFAM AMP-dependent synthetase and ligase
D0819_19315	COG2226	methyltransferase
D0819_19320	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_19325	COG1917	Cupin 2, conserved barrel domain protein
D0819_19330	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0819_19335	COG3871	stress protein (general stress protein 26)
D0819_19345	COG2814	Major facilitator Superfamily
D0819_19350	COG1522	sequence-specific DNA binding
D0819_19355	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D0819_19355	COG0551	DNA topoisomerase type I activity
D0819_19360	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
D0819_19365	COG3706	GGDEF domain
D0819_19370	COG5298	Protein conserved in bacteria
D0819_19375	COG1215	transferase activity, transferring glycosyl groups
D0819_19385	COG0531	amino acid
D0819_19390	COG0494	nUDIX hydrolase
D0819_19395	COG0028	Belongs to the TPP enzyme family
D0819_19405	COG1914	H( )-stimulated, divalent metal cation uptake system
D0819_19410	COG2261	transglycosylase associated protein
D0819_19415	COG4876	unkown
D0819_19420	COG2217	Heavy metal translocating P-type atpase
D0819_19425	COG3729	General stress protein
D0819_19430	COG0662	Cupin 2, conserved barrel domain protein
D0819_19435	COG2329	Antibiotic biosynthesis monooxygenase
D0819_19440	COG3546	catalase activity
D0819_19445	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
D0819_19450	COG3290	protein histidine kinase activity
D0819_19455	COG4565	transcriptional regulatory protein
D0819_19460	COG1301	dicarboxylic acid transport
D0819_19465	COG0628	permease
D0819_19470	COG1131	(ABC) transporter
D0819_19475	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
D0819_19485	COG1960	acyl-CoA dehydrogenase activity
D0819_19500	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D0819_19505	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0819_19510	COG1181	Belongs to the D-alanine--D-alanine ligase family
D0819_19515	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D0819_19525	COG0513	Belongs to the DEAD box helicase family
D0819_19530	COG3402	PFAM membrane-flanked domain
D0819_19535	COG3428	Bacterial PH domain
D0819_19540	COG0705	Rhomboid family
D0819_19545	COG0736	holo-[acyl-carrier-protein] synthase activity
D0819_19550	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D0819_19555	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D0819_19560	COG0864	Transcriptional regulator
D0819_19565	COG2337	Toxic component of a toxin-antitoxin (TA) module
D0819_19570	COG1366	Belongs to the anti-sigma-factor antagonist family
D0819_19575	COG1366	Belongs to the anti-sigma-factor antagonist family
D0819_19580	COG2172	sigma factor antagonist activity
D0819_19585	COG2208	phosphoserine phosphatase activity
D0819_19590	COG1366	Belongs to the anti-sigma-factor antagonist family
D0819_19595	COG2172	sigma factor antagonist activity
D0819_19600	COG1191	sigma factor activity
D0819_19605	COG2208	phosphoserine phosphatase activity
D0819_19615	COG1673	EVE domain
D0819_19620	COG1846	Transcriptional regulator
D0819_19625	COG2183	response to ionizing radiation
D0819_19635	COG3091	SprT-like family
D0819_19675	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
D0819_19680	COG1522	sequence-specific DNA binding
D0819_19685	COG1522	sequence-specific DNA binding
D0819_19690	COG1335	isochorismatase
D0819_19695	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
D0819_19700	COG2814	Major facilitator Superfamily
D0819_19715	COG5444	nuclease activity
D0819_19725	COG3239	Fatty acid desaturase
D0819_19730	COG1278	Cold shock
D0819_19735	COG1329	Transcriptional regulator
D0819_19750	COG1917	Cupin 2, conserved barrel domain protein
D0819_19750	COG2207	Transcriptional regulator
D0819_19755	COG0697	spore germination
D0819_19760	COG2207	Transcriptional regulator
D0819_19760	COG3708	Transcriptional regulator
D0819_19765	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0819_19770	COG0477	Major facilitator Superfamily
D0819_19780	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
D0819_19795	COG0697	spore germination
D0819_19800	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0819_19805	COG2030	dehydratase
D0819_19810	COG3545	Serine hydrolase
D0819_19815	COG1733	regulation of RNA biosynthetic process
D0819_19820	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
D0819_19825	COG0640	Transcriptional regulator
D0819_19830	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D0819_19840	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D0819_19850	COG0726	polysaccharide deacetylase
D0819_19860	COG5002	protein histidine kinase activity
D0819_19865	COG0745	RESPONSE REGULATOR receiver
D0819_19870	COG0697	spore germination
D0819_19875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
D0819_19880	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
D0819_19885	COG0640	Transcriptional regulator
D0819_19890	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
D0819_19905	COG4585	Histidine kinase
D0819_19910	COG2197	response regulator
D0819_19915	COG2409	Drug exporters of the RND superfamily
D0819_19920	COG1811	Na channel or pump
D0819_19925	COG0789	Transcriptional regulator
D0819_19925	COG4978	Transcriptional regulator
D0819_19930	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D0819_19935	COG0778	Nitroreductase
D0819_19940	COG0346	lactoylglutathione lyase activity
D0819_19945	COG2259	Doxx family
D0819_19950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
D0819_19970	COG2323	membrane
D0819_19975	COG0071	Belongs to the small heat shock protein (HSP20) family
D0819_19990	COG1309	transcriptional regulator
D0819_20010	COG1113	amino acid transport
D0819_20015	COG2318	DinB family
D0819_20020	COG1846	Transcriptional regulator
D0819_20025	COG1033	growth of symbiont in host cell
D0819_20025	COG2409	Drug exporters of the RND superfamily
D0819_20030	COG0778	Nitroreductase
D0819_20035	COG1846	Transcriptional regulator
D0819_20040	COG2814	Major facilitator Superfamily
D0819_20045	COG0730	response to heat
D0819_20050	COG1802	Transcriptional regulator
D0819_20055	COG3858	chitin binding
D0819_20055	COG1388	LysM domain
D0819_20060	COG1819	glycosyl
D0819_20070	COG1785	Belongs to the alkaline phosphatase family
D0819_20075	COG5646	InterPro IPR014922
D0819_20085	COG0454	-acetyltransferase
D0819_20090	COG1078	dGTPase activity
D0819_20095	COG1388	LysM domain
D0819_20100	COG2814	Major facilitator Superfamily
D0819_20105	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0819_20110	COG1447	Phosphotransferase system cellobiose-specific component IIA
D0819_20115	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
D0819_20120	COG2723	6-phospho-beta-galactosidase activity
D0819_20125	COG2188	Transcriptional regulator
D0819_20130	COG1940	carbohydrate kinase activity
D0819_20135	COG1482	cell wall glycoprotein biosynthetic process
D0819_20140	COG4124	Belongs to the glycosyl hydrolase 26 family
D0819_20185	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D0819_20190	COG0802	atpase or kinase
D0819_20195	COG1214	PFAM Peptidase M22, glycoprotease
D0819_20200	COG0456	acetyltransferase
D0819_20205	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D0819_20210	COG0488	(ABC) transporter
D0819_20215	COG0315	cyclic pyranopterin monophosphate synthase activity
D0819_20220	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
D0819_20225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D0819_20230	COG0805	protein transport
D0819_20245	COG1266	CAAX protease self-immunity
D0819_20250	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D0819_20255	COG0459	protein refolding
D0819_20305	COG0457	Tetratricopeptide repeat
D0819_20310	COG1063	alcohol dehydrogenase
D0819_20315	COG2211	Major facilitator Superfamily
D0819_20320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
D0819_20325	COG1842	Phage shock protein A
D0819_20330	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D0819_20335	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
D0819_20340	COG4260	virion core protein, lumpy skin disease virus
D0819_20350	COG2814	Major facilitator Superfamily
D0819_20355	COG1063	alcohol dehydrogenase
D0819_20360	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D0819_20365	COG0823	Involved in the tonB-independent uptake of proteins
D0819_20380	COG2267	carboxylic ester hydrolase activity
D0819_20390	COG2132	Multicopper oxidase
D0819_20395	COG1113	amino acid transport
D0819_20405	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D0819_20410	COG0714	Associated with various cellular activities
D0819_20415	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
D0819_20420	COG1305	Transglutaminase-like
D0819_20425	COG0519	Catalyzes the synthesis of GMP from XMP
D0819_20425	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D0819_20440	COG2252	PERMEase
D0819_20445	COG3064	Membrane
D0819_20455	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
D0819_20465	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D0819_20470	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
D0819_20475	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D0819_20480	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
D0819_20485	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D0819_20490	COG0047	phosphoribosylformylglycinamidine synthase activity
D0819_20495	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D0819_20500	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D0819_20505	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D0819_20510	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D0819_20515	COG0138	bifunctional purine biosynthesis protein purh
D0819_20520	COG0151	Belongs to the GarS family
D0819_20525	COG1522	sequence-specific DNA binding
D0819_20530	COG0531	amino acid
D0819_20540	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
D0819_20545	COG1470	cell adhesion involved in biofilm formation
D0819_20550	COG4496	protein, YerC YecD
D0819_20555	COG0069	glutamate synthase activity
D0819_20560	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
D0819_20565	COG0210	DNA helicase
D0819_20570	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D0819_20575	COG4851	CamS sex pheromone cAM373 precursor
D0819_20580	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
D0819_20585	COG1285	pathogenesis
D0819_20590	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D0819_20595	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D0819_20600	COG0154	amidase activity
D0819_20605	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
D0819_20610	COG1309	transcriptional regulator
D0819_20615	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
D0819_20620	COG1597	lipid kinase activity
D0819_20625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D0819_20660	COG5444	nuclease activity
D0819_20675	COG0457	Tetratricopeptide repeat
D0819_20685	COG0217	transcriptional regulatory protein
D0819_20695	COG1309	transcriptional regulator
D0819_20700	COG3631	Ketosteroid isomerase-related protein
D0819_20705	COG0702	epimerase
D0819_20720	COG3546	catalase activity
D0819_20725	COG0454	-acetyltransferase
D0819_20735	COG5578	integral membrane protein
D0819_20740	COG2972	Histidine kinase
D0819_20745	COG2207	Transcriptional regulator
D0819_20745	COG4753	response regulator
D0819_20750	COG1653	transport
D0819_20755	COG1175	transmembrane transport
D0819_20760	COG0395	ABC-type sugar transport system, permease component
D0819_20765	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
D0819_20770	COG2207	Transcriptional regulator
D0819_20775	COG2755	lipolytic protein G-D-S-L family
D0819_20785	COG5578	integral membrane protein
D0819_20790	COG3401	FG-GAP repeat protein
D0819_20795	COG3401	FG-GAP repeat protein
D0819_20800	COG2755	lipolytic protein G-D-S-L family
D0819_20805	COG1874	Beta-galactosidase
D0819_20815	COG1653	transport
D0819_20820	COG4209	transmembrane transport
D0819_20825	COG0395	ABC-type sugar transport system, permease component
D0819_20830	COG1486	melibiose metabolic process
D0819_20835	COG2323	membrane
D0819_20840	COG2329	Antibiotic biosynthesis monooxygenase
D0819_20845	COG0346	lactoylglutathione lyase activity
D0819_20860	COG5583	Uncharacterized small protein (DUF2292)
D0819_20865	COG0670	Belongs to the BI1 family
D0819_20875	COG1846	Transcriptional regulator
D0819_20880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
D0819_20900	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
D0819_20900	COG2124	cytochrome p450
D0819_20910	COG1368	sulfuric ester hydrolase activity
D0819_20915	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D0819_20920	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D0819_20925	COG1442	glycosyl transferase family 8
D0819_20930	COG1216	Glycosyl transferase, family 2
D0819_20935	COG1442	glycosyl transferase family 8
D0819_20940	COG2223	nitrite transmembrane transporter activity
D0819_20945	COG1011	Hydrolase
D0819_20950	COG0531	amino acid
D0819_20955	COG1012	belongs to the aldehyde dehydrogenase family
D0819_20960	COG0840	transmembrane signaling receptor activity
D0819_20965	COG0488	(ABC) transporter
D0819_20975	COG0789	Transcriptional regulator
D0819_20980	COG2814	Major facilitator Superfamily
D0819_20985	COG1404	Belongs to the peptidase S8 family
D0819_21000	COG0488	(ABC) transporter
D0819_21005	COG0513	Belongs to the DEAD box helicase family
D0819_21010	COG0456	acetyltransferase
D0819_21015	COG2130	NADP-dependent
D0819_21020	COG1120	ATPase activity
D0819_21025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0819_21030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0819_21035	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
D0819_21055	COG3866	Pectate lyase
D0819_21060	COG0471	metal ion transport
D0819_21065	COG3290	protein histidine kinase activity
D0819_21070	COG4565	transcriptional regulatory protein
D0819_21075	COG3181	Tripartite tricarboxylate transporter family receptor
D0819_21080	COG2851	Citrate transporter
D0819_21085	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
D0819_21090	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
D0819_21095	COG1254	Belongs to the acylphosphatase family
D0819_21100	COG2258	MOSC domain
D0819_21120	COG0024	Methionine aminopeptidase
D0819_21125	COG1263	PTS System
D0819_21125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0819_21130	COG1368	sulfuric ester hydrolase activity
D0819_21145	COG1115	amino acid carrier protein
D0819_21150	COG0531	amino acid
D0819_21165	COG0697	spore germination
D0819_21170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0819_21170	COG1263	PTS System
D0819_21175	COG0366	Alpha amylase catalytic
D0819_21180	COG2188	Transcriptional regulator
D0819_21185	COG0778	Nitroreductase
D0819_21190	COG0737	Belongs to the 5'-nucleotidase family
D0819_21195	COG0693	protein deglycase activity
D0819_21200	COG2814	Major facilitator Superfamily
D0819_21205	COG4840	Belongs to the UPF0435 family
D0819_21210	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D0819_21215	COG4980	gas vesicle protein
D0819_21220	COG1295	ribonuclease BN
D0819_21225	COG0477	Major facilitator Superfamily
D0819_21230	COG0387	Pfam Sodium calcium exchanger
D0819_21240	COG0668	transmembrane transport
D0819_21245	COG0535	radical SAM domain protein
D0819_21255	COG0726	polysaccharide deacetylase
D0819_21260	COG2084	Dehydrogenase
D0819_21265	COG0598	Magnesium transport protein CorA
D0819_21270	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
D0819_21275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
D0819_21290	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D0819_21295	COG4637	Psort location Cytoplasmic, score
D0819_21300	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
D0819_21305	COG0022	dehydrogenase e1 component
D0819_21310	COG0508	dehydrogenase complex catalyzes the overall conversion of
D0819_21315	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D0819_21320	COG3284	Transcriptional regulator
D0819_21330	COG1742	UPF0060 membrane protein
D0819_21350	COG4842	Belongs to the WXG100 family
D0819_21355	COG1486	melibiose metabolic process
D0819_21360	COG1737	Transcriptional regulator
D0819_21365	COG1263	PTS System
D0819_21365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D0819_21370	COG5434	Belongs to the glycosyl hydrolase 28 family
D0819_21375	COG1132	(ABC) transporter
D0819_21380	COG1132	(ABC) transporter
D0819_21385	COG2259	Doxx family
D0819_21390	COG2514	catechol 2,3-dioxygenase activity
D0819_21395	COG4585	Histidine kinase
D0819_21400	COG2197	response regulator
D0819_21410	COG1131	(ABC) transporter
D0819_21415	COG0842	Transport permease protein
D0819_21415	COG1511	domain protein
D0819_21420	COG0842	Transport permease protein
D0819_21425	COG1695	Transcriptional regulator
D0819_21430	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
D0819_21435	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
D0819_21440	COG1309	transcriptional regulator
D0819_21450	COG2318	DinB family
D0819_21455	COG2814	Major facilitator Superfamily
D0819_21460	COG1846	Transcriptional regulator
D0819_21465	COG0392	lysyltransferase activity
D0819_21465	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
D0819_21470	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D0819_21475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0819_21480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D0819_21485	COG0384	phenazine biosynthesis protein PhzF
D0819_21490	COG0778	Nitroreductase
D0819_21505	COG1090	epimerase
D0819_21510	COG2137	regulation of response to DNA damage stimulus
D0819_21520	COG2814	Major facilitator Superfamily
D0819_21535	COG3103	Sh3 type 3 domain protein
D0819_21540	COG5658	integral membrane protein
D0819_21545	COG0596	Alpha beta hydrolase
D0819_21550	COG0463	Glycosyl transferase, family 2
D0819_21555	COG4485	Bacterial membrane protein, YfhO
D0819_21560	COG1988	membrane-bound metal-dependent
D0819_21565	COG1194	a g-specific adenine glycosylase
D0819_21575	COG1028	Short-chain dehydrogenase reductase Sdr
D0819_21590	COG3557	Belongs to the UPF0374 family
D0819_21595	COG1132	(ABC) transporter
D0819_21600	COG4129	membrane
D0819_21605	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
D0819_21610	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D0819_21615	COG0735	belongs to the Fur family