locus-tag	class	description
A4A60_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A4A60_00010	COG0592	DNA-directed DNA polymerase activity
A4A60_00015	COG2501	S4 domain
A4A60_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A4A60_00030	COG0187	DNA topoisomerase II activity
A4A60_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4A60_00070	COG0517	IMP dehydrogenase activity
A4A60_00070	COG0516	GMP reductase activity
A4A60_00075	COG1686	Belongs to the peptidase S11 family
A4A60_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
A4A60_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
A4A60_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A4A60_00100	COG1428	Deoxynucleoside kinase
A4A60_00105	COG1428	Deoxynucleoside kinase
A4A60_00110	COG1388	LysM domain
A4A60_00110	COG3858	chitin binding
A4A60_00115	COG1335	isochorismatase
A4A60_00120	COG0590	tRNA wobble adenosine to inosine editing
A4A60_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A4A60_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A4A60_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A4A60_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
A4A60_00190	COG3853	Toxic anion resistance protein (TelA)
A4A60_00195	COG1982	Orn Lys Arg decarboxylase major
A4A60_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A4A60_00205	COG3870	Protein conserved in bacteria
A4A60_00210	COG1728	Protein conserved in bacteria
A4A60_00215	COG0470	DNA polymerase III
A4A60_00220	COG1774	PSP1 C-terminal conserved region
A4A60_00225	COG4467	Involved in initiation control of chromosome replication
A4A60_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A4A60_00235	COG2827	Endonuclease containing a URI domain
A4A60_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A4A60_00245	COG3328	transposase activity
A4A60_00250	COG2002	toxin-antitoxin pair type II binding
A4A60_00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4A60_00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4A60_00260	COG0084	hydrolase, TatD family'
A4A60_00265	COG3583	domain protein
A4A60_00265	COG3584	3D domain protein
A4A60_00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A4A60_00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4A60_00285	COG4466	Protein conserved in bacteria
A4A60_00295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A4A60_00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4A60_00305	COG0251	oxidation-reduction process
A4A60_00310	COG2088	sporulation resulting in formation of a cellular spore
A4A60_00320	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A4A60_00325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A4A60_00330	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A4A60_00335	COG0193	aminoacyl-tRNA hydrolase activity
A4A60_00345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A4A60_00350	COG2002	toxin-antitoxin pair type II binding
A4A60_00355	COG2244	polysaccharide biosynthetic process
A4A60_00360	COG3956	TIGRFAM MazG family protein
A4A60_00365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A4A60_00380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A4A60_00385	COG1098	S1 RNA binding domain
A4A60_00400	COG2208	phosphoserine phosphatase activity
A4A60_00405	COG2304	oxidoreductase activity
A4A60_00410	COG0515	serine threonine protein kinase
A4A60_00415	COG0037	tRNA processing
A4A60_00425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4A60_00430	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A4A60_00435	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A4A60_00440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4A60_00445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4A60_00450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A4A60_00455	COG0512	Glutamine amidotransferase of anthranilate synthase
A4A60_00460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4A60_00465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A4A60_00470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
A4A60_00475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A4A60_00480	COG1396	sequence-specific DNA binding
A4A60_00485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4A60_00490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A4A60_00570	COG4463	regulation of RNA biosynthetic process
A4A60_00575	COG3880	PFAM UvrB UvrC protein
A4A60_00580	COG3869	Catalyzes the specific phosphorylation of arginine residues in
A4A60_00585	COG0542	response to heat
A4A60_00590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A4A60_00595	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
A4A60_00600	COG4956	integral membrane protein (PIN domain superfamily)
A4A60_00605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A4A60_00610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A4A60_00615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4A60_00625	COG1045	serine acetyltransferase
A4A60_00630	COG0215	cysteine-tRNA ligase activity
A4A60_00635	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A4A60_00640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4A60_00645	COG3688	RNA-binding protein containing a PIN domain
A4A60_00650	COG1595	DNA-templated transcription, initiation
A4A60_00655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A4A60_00660	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4A60_00665	COG0250	Participates in transcription elongation, termination and antitermination
A4A60_00670	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A4A60_00675	COG0081	regulation of translation
A4A60_00680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A4A60_00685	COG0222	ribosome binding
A4A60_00690	COG2813	Specifically methylates the guanine in position
A4A60_00695	COG0085	RNA polymerase activity
A4A60_00700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A4A60_00705	COG1358	cellular component organization or biogenesis
A4A60_00710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A4A60_00715	COG0049	tRNA binding
A4A60_00720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A4A60_00725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A4A60_00730	COG0596	Alpha beta hydrolase
A4A60_00735	COG0051	transcription antitermination factor activity, RNA binding
A4A60_00740	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A4A60_00745	COG0088	Forms part of the polypeptide exit tunnel
A4A60_00750	COG0089	rRNA binding
A4A60_00755	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A4A60_00760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A4A60_00765	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A4A60_00770	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A4A60_00775	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A4A60_00780	COG0255	Belongs to the universal ribosomal protein uL29 family
A4A60_00785	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A4A60_00790	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A4A60_00800	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A4A60_00810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A4A60_00815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A4A60_00820	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A4A60_00825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A4A60_00830	COG1841	ribosomal large subunit assembly
A4A60_00835	COG0200	Binds to the 23S rRNA
A4A60_00840	COG0201	protein transport
A4A60_00845	COG0563	adenylate kinase activity
A4A60_00850	COG0024	Methionine aminopeptidase
A4A60_00855	COG2163	COG2163 Ribosomal protein L14E L6E L27E
A4A60_00860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A4A60_00865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A4A60_00870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A4A60_00875	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A4A60_00880	COG0202	RNA polymerase activity
A4A60_00885	COG0203	ribosomal protein L17
A4A60_00890	COG1122	ATPase activity
A4A60_00895	COG1122	ATPase activity
A4A60_00900	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A4A60_00905	COG0101	tRNA pseudouridine synthase activity
A4A60_00910	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A4A60_00915	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A4A60_00920	COG2226	methyltransferase
A4A60_00930	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4A60_00935	COG0489	protein tyrosine kinase activity
A4A60_00945	COG2194	sulfuric ester hydrolase activity
A4A60_00950	COG0726	polysaccharide deacetylase
A4A60_01035	COG0659	secondary active sulfate transmembrane transporter activity
A4A60_01040	COG0385	Bile acid
A4A60_01045	COG2819	hydrolase of the alpha beta superfamily
A4A60_01050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4A60_01055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4A60_01060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4A60_01065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4A60_01065	COG2207	Transcriptional regulator
A4A60_01075	COG1472	Belongs to the glycosyl hydrolase 3 family
A4A60_01080	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A4A60_01085	COG1263	PTS System
A4A60_01085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4A60_01090	COG1737	Transcriptional regulator
A4A60_01095	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A4A60_01100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4A60_01105	COG1683	Conserved Protein
A4A60_01135	COG1595	DNA-templated transcription, initiation
A4A60_01140	COG5662	AntiSigma factor
A4A60_01145	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A4A60_01150	COG4856	YbbR-like protein
A4A60_01155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4A60_01160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A4A60_01190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A4A60_01195	COG3002	Belongs to the UPF0753 family
A4A60_01200	COG0288	reversible hydration of carbon dioxide
A4A60_01210	COG5609	conserved protein (DUF2294)
A4A60_01230	COG0515	serine threonine protein kinase
A4A60_01245	COG1113	amino acid transport
A4A60_01265	COG2602	Beta-lactamase
A4A60_01270	COG2124	cytochrome p450
A4A60_01280	COG0531	amino acid
A4A60_01285	COG0584	glycerophosphoryl diester phosphodiesterase
A4A60_01290	COG2271	Major facilitator Superfamily
A4A60_01300	COG0456	acetyltransferase
A4A60_01300	COG1846	Transcriptional regulator
A4A60_01320	COG3409	Peptidoglycan-binding domain 1 protein
A4A60_01330	COG1917	Cupin 2, conserved barrel domain protein
A4A60_01330	COG2207	Transcriptional regulator
A4A60_01345	COG3179	chitinase
A4A60_01355	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
A4A60_01360	COG3591	Belongs to the peptidase S1B family
A4A60_01370	COG0596	Alpha beta hydrolase
A4A60_01375	COG1183	phosphatidylcholine synthase activity
A4A60_01380	COG0586	Pfam SNARE associated Golgi protein
A4A60_01385	COG0688	phosphatidylethanolamine metabolic process
A4A60_01395	COG2312	Erythromycin esterase
A4A60_01400	COG2207	Transcriptional regulator
A4A60_01415	COG1301	dicarboxylic acid transport
A4A60_01420	COG2190	(PTS) system
A4A60_01420	COG1263	PTS System
A4A60_01420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4A60_01425	COG0363	glucosamine-6-phosphate deaminase activity
A4A60_01440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4A60_01445	COG0833	amino acid
A4A60_01450	COG2040	homocysteine
A4A60_01465	COG2066	Belongs to the glutaminase family
A4A60_01470	COG4191	Histidine kinase
A4A60_01475	COG0784	Response regulator, receiver
A4A60_01480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4A60_01485	COG1012	belongs to the aldehyde dehydrogenase family
A4A60_01490	COG2271	Major facilitator Superfamily
A4A60_01495	COG4948	Mandelate Racemase Muconate Lactonizing
A4A60_01500	COG2186	Transcriptional regulator
A4A60_01505	COG2721	sulfolactate sulfo-lyase activity
A4A60_01510	COG3173	Aminoglycoside phosphotransferase
A4A60_01520	COG0697	spore germination
A4A60_01525	COG0745	RESPONSE REGULATOR receiver
A4A60_01530	COG2205	protein histidine kinase activity
A4A60_01535	COG1131	(ABC) transporter
A4A60_01555	COG3773	Cell wall hydrolase
A4A60_01570	COG3540	Alkaline phosphatase
A4A60_01575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4A60_01580	COG0805	protein transport
A4A60_01585	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A4A60_01590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4A60_01595	COG0477	Major facilitator Superfamily
A4A60_01600	COG1309	transcriptional regulator
A4A60_01605	COG0252	asparaginase activity
A4A60_01610	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A4A60_01615	COG1714	RDD family
A4A60_01620	COG1405	negative regulation of cell septum assembly
A4A60_01620	COG3012	SEC-C Motif Domain Protein
A4A60_01625	COG3290	protein histidine kinase activity
A4A60_01630	COG3279	Response regulator of the LytR AlgR family
A4A60_01635	COG4555	ABC transporter
A4A60_01640	COG1668	transmembrane transport
A4A60_01655	COG1595	DNA-templated transcription, initiation
A4A60_01660	COG1595	DNA-templated transcription, initiation
A4A60_01665	COG1876	peptidase activity
A4A60_01670	COG0457	Tetratricopeptide repeat
A4A60_01675	COG1028	Short-chain dehydrogenase reductase Sdr
A4A60_01680	COG0366	Alpha amylase catalytic
A4A60_01685	COG0803	Belongs to the bacterial solute-binding protein 9 family
A4A60_01690	COG1121	(ABC) transporter
A4A60_01695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4A60_01710	COG2310	stress, protein
A4A60_01715	COG2310	stress, protein
A4A60_01720	COG2310	stress, protein
A4A60_01725	COG0861	Integral membrane protein TerC family
A4A60_01735	COG3853	Toxic anion resistance protein (TelA)
A4A60_01740	COG0477	Major facilitator Superfamily
A4A60_01745	COG2814	Major facilitator Superfamily
A4A60_01750	COG1104	cysteine desulfurase activity
A4A60_01790	COG0640	Transcriptional regulator
A4A60_01795	COG4175	Glycine betaine
A4A60_01795	COG0517	IMP dehydrogenase activity
A4A60_01800	COG4176	ABC-type proline glycine betaine transport system permease component
A4A60_01805	COG2113	Glycine betaine
A4A60_01810	COG1473	amidohydrolase
A4A60_01815	COG1288	antiporter activity
A4A60_01835	COG0039	L-malate dehydrogenase activity
A4A60_01840	COG1620	l-lactate permease
A4A60_01845	COG3403	YqcI/YcgG family
A4A60_01855	COG3665	Urea carboxylase-associated protein
A4A60_01860	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A4A60_01865	COG1660	Displays ATPase and GTPase activities
A4A60_01870	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4A60_01875	COG2226	methyltransferase
A4A60_01880	COG0583	DNA-binding transcription factor activity
A4A60_01885	COG3458	cephalosporin-C deacetylase activity
A4A60_01890	COG3541	Predicted nucleotidyltransferase
A4A60_01895	COG0506	proline dehydrogenase activity
A4A60_01900	COG1012	belongs to the aldehyde dehydrogenase family
A4A60_01905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4A60_01910	COG2508	Transcriptional regulator
A4A60_01915	COG3689	TIGRFAM TIGR03943 family protein
A4A60_01920	COG0701	Predicted permease
A4A60_01925	COG2267	carboxylic ester hydrolase activity
A4A60_01930	COG0492	ferredoxin-NADP+ reductase activity
A4A60_01935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A4A60_01935	COG1587	Uroporphyrinogen-III synthase
A4A60_01940	COG2146	nitrite reductase [NAD(P)H] activity
A4A60_01945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4A60_01950	COG0243	molybdopterin cofactor binding
A4A60_01955	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4A60_01960	COG2223	nitrite transmembrane transporter activity
A4A60_01970	COG1376	ErfK ybiS ycfS ynhG family protein
A4A60_01985	COG0765	amino acid transport
A4A60_01990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4A60_02000	COG1714	RDD family
A4A60_02010	COG1846	Transcriptional regulator
A4A60_02025	COG2723	6-phospho-beta-galactosidase activity
A4A60_02035	COG3209	COG3209 Rhs family protein
A4A60_02045	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A4A60_02050	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
A4A60_02055	COG1733	regulation of RNA biosynthetic process
A4A60_02070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4A60_02075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4A60_02080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4A60_02085	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
A4A60_02090	COG2814	Major facilitator Superfamily
A4A60_02100	COG0697	spore germination
A4A60_02105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4A60_02115	COG2364	Membrane
A4A60_02120	COG1126	abc transporter atp-binding protein
A4A60_02125	COG0765	amino acid transport
A4A60_02130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4A60_02135	COG0583	DNA-binding transcription factor activity
A4A60_02140	COG0163	prenyltransferase activity
A4A60_02145	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A4A60_02160	COG0596	Alpha beta hydrolase
A4A60_02165	COG3104	oligopeptide transport
A4A60_02170	COG5434	Belongs to the glycosyl hydrolase 28 family
A4A60_02185	COG0697	spore germination
A4A60_02195	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A4A60_02200	COG1136	(ABC) transporter
A4A60_02205	COG0577	efflux transmembrane transporter activity
A4A60_02210	COG0745	RESPONSE REGULATOR receiver
A4A60_02215	COG5002	protein histidine kinase activity
A4A60_02215	COG3850	Histidine kinase
A4A60_02220	COG0457	Tetratricopeptide repeat
A4A60_02235	COG0527	aspartate kinase activity
A4A60_02240	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4A60_02245	COG4605	iron ion homeostasis
A4A60_02250	COG4604	ABC transporter, ATP-binding protein
A4A60_02255	COG4607	ABC-type enterochelin transport system periplasmic component
A4A60_02260	COG2814	Major facilitator Superfamily
A4A60_02265	COG1309	transcriptional regulator
A4A60_02270	COG0778	Nitroreductase
A4A60_02275	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A4A60_02280	COG0640	Transcriptional regulator
A4A60_02285	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4A60_02290	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
A4A60_02295	COG1012	belongs to the aldehyde dehydrogenase family
A4A60_02300	COG4975	Glucose uptake
A4A60_02305	COG1028	Short-chain dehydrogenase reductase Sdr
A4A60_02310	COG4549	nuclear export factor GLE1
A4A60_02315	COG1276	copper resistance
A4A60_02315	COG2372	response to copper ion
A4A60_02320	COG1349	DNA-binding transcription factor activity
A4A60_02330	COG2213	PTS system mannitol-specific
A4A60_02335	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4A60_02340	COG0246	Mannitol dehydrogenase
A4A60_02345	COG0473	3-isopropylmalate dehydrogenase activity
A4A60_02350	COG0681	Belongs to the peptidase S26 family
A4A60_02360	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A4A60_02365	COG2801	Transposase and inactivated derivatives
A4A60_02380	COG0561	phosphatase activity
A4A60_02385	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A4A60_02390	COG1914	H( )-stimulated, divalent metal cation uptake system
A4A60_02395	COG4336	lyase activity
A4A60_02400	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A4A60_02405	COG1984	allophanate hydrolase subunit 2
A4A60_02410	COG1414	Transcriptional regulator
A4A60_02415	COG2755	lipolytic protein G-D-S-L family
A4A60_02425	COG2329	Antibiotic biosynthesis monooxygenase
A4A60_02430	COG0768	penicillin binding
A4A60_02435	COG4989	oxidoreductase activity
A4A60_02440	COG3711	transcriptional antiterminator
A4A60_02445	COG0318	PFAM AMP-dependent synthetase and ligase
A4A60_02450	COG2226	methyltransferase
A4A60_02455	COG1028	Short-chain dehydrogenase reductase Sdr
A4A60_02460	COG1917	Cupin 2, conserved barrel domain protein
A4A60_02465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4A60_02470	COG3871	stress protein (general stress protein 26)
A4A60_02480	COG2814	Major facilitator Superfamily
A4A60_02485	COG1522	sequence-specific DNA binding
A4A60_02490	COG0551	DNA topoisomerase type I activity
A4A60_02490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4A60_02495	COG0494	nUDIX hydrolase
A4A60_02500	COG0028	Belongs to the TPP enzyme family
A4A60_02525	COG1914	H( )-stimulated, divalent metal cation uptake system
A4A60_02530	COG2261	transglycosylase associated protein
A4A60_02535	COG4876	unkown
A4A60_02540	COG2217	Heavy metal translocating P-type atpase
A4A60_02545	COG3729	General stress protein
A4A60_02550	COG0662	Cupin 2, conserved barrel domain protein
A4A60_02555	COG2329	Antibiotic biosynthesis monooxygenase
A4A60_02560	COG3546	catalase activity
A4A60_02565	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A4A60_02570	COG3290	protein histidine kinase activity
A4A60_02575	COG4565	transcriptional regulatory protein
A4A60_02580	COG1301	dicarboxylic acid transport
A4A60_02585	COG0628	permease
A4A60_02595	COG1131	(ABC) transporter
A4A60_02600	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A4A60_02610	COG1960	acyl-CoA dehydrogenase activity
A4A60_02625	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A4A60_02630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4A60_02635	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4A60_02640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A4A60_02645	COG0513	Belongs to the DEAD box helicase family
A4A60_02650	COG3402	PFAM membrane-flanked domain
A4A60_02655	COG3428	Bacterial PH domain
A4A60_02660	COG0705	Rhomboid family
A4A60_02665	COG0736	holo-[acyl-carrier-protein] synthase activity
A4A60_02670	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A4A60_02675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4A60_02680	COG0864	Transcriptional regulator
A4A60_02685	COG2337	Toxic component of a toxin-antitoxin (TA) module
A4A60_02690	COG1366	Belongs to the anti-sigma-factor antagonist family
A4A60_02695	COG1366	Belongs to the anti-sigma-factor antagonist family
A4A60_02700	COG2172	sigma factor antagonist activity
A4A60_02705	COG2208	phosphoserine phosphatase activity
A4A60_02710	COG1366	Belongs to the anti-sigma-factor antagonist family
A4A60_02715	COG2172	sigma factor antagonist activity
A4A60_02720	COG1191	sigma factor activity
A4A60_02725	COG2208	phosphoserine phosphatase activity
A4A60_02730	COG2183	response to ionizing radiation
A4A60_02740	COG3091	SprT-like family
A4A60_02785	COG0583	DNA-binding transcription factor activity
A4A60_02790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4A60_02800	COG5444	nuclease activity
A4A60_02805	COG1476	TRANSCRIPTIONal
A4A60_02830	COG0693	protein deglycase activity
A4A60_02835	COG1278	Cold shock
A4A60_02840	COG1329	Transcriptional regulator
A4A60_02850	COG0697	spore germination
A4A60_02855	COG2207	Transcriptional regulator
A4A60_02855	COG1917	Cupin 2, conserved barrel domain protein
A4A60_02860	COG0697	spore germination
A4A60_02865	COG2207	Transcriptional regulator
A4A60_02865	COG3708	Transcriptional regulator
A4A60_02870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4A60_02880	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
A4A60_02895	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4A60_02900	COG1309	transcriptional regulator
A4A60_02905	COG0697	spore germination
A4A60_02910	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4A60_02915	COG2030	dehydratase
A4A60_02920	COG3545	Serine hydrolase
A4A60_02925	COG1733	regulation of RNA biosynthetic process
A4A60_02930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4A60_02935	COG0640	Transcriptional regulator
A4A60_02940	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A4A60_02950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4A60_02955	COG0697	spore germination
A4A60_02960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4A60_02965	COG0076	glutamate decarboxylase activity
A4A60_02970	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A4A60_02975	COG0640	Transcriptional regulator
A4A60_02990	COG4585	Histidine kinase
A4A60_02995	COG2197	response regulator
A4A60_03000	COG2409	Drug exporters of the RND superfamily
A4A60_03010	COG0596	Alpha beta hydrolase
A4A60_03015	COG1811	Na channel or pump
A4A60_03020	COG0789	Transcriptional regulator
A4A60_03020	COG4978	Transcriptional regulator
A4A60_03025	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A4A60_03030	COG0778	Nitroreductase
A4A60_03035	COG0346	lactoylglutathione lyase activity
A4A60_03040	COG2259	Doxx family
A4A60_03045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4A60_03065	COG2323	membrane
A4A60_03070	COG2323	membrane
A4A60_03075	COG0071	Belongs to the small heat shock protein (HSP20) family
A4A60_03090	COG1309	transcriptional regulator
A4A60_03100	COG0456	acetyltransferase
A4A60_03110	COG1113	amino acid transport
A4A60_03115	COG2318	DinB family
A4A60_03120	COG1846	Transcriptional regulator
A4A60_03125	COG1033	growth of symbiont in host cell
A4A60_03125	COG2409	Drug exporters of the RND superfamily
A4A60_03130	COG0778	Nitroreductase
A4A60_03135	COG1846	Transcriptional regulator
A4A60_03140	COG2814	Major facilitator Superfamily
A4A60_03145	COG0730	response to heat
A4A60_03150	COG1802	Transcriptional regulator
A4A60_03155	COG1388	LysM domain
A4A60_03155	COG3858	chitin binding
A4A60_03160	COG1819	glycosyl
A4A60_03170	COG1785	Belongs to the alkaline phosphatase family
A4A60_03175	COG5646	InterPro IPR014922
A4A60_03185	COG0454	-acetyltransferase
A4A60_03190	COG1078	dGTPase activity
A4A60_03195	COG1388	LysM domain
A4A60_03200	COG2814	Major facilitator Superfamily
A4A60_03205	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4A60_03220	COG2723	6-phospho-beta-galactosidase activity
A4A60_03225	COG2188	Transcriptional regulator
A4A60_03230	COG1940	carbohydrate kinase activity
A4A60_03240	COG4124	Belongs to the glycosyl hydrolase 26 family
A4A60_03285	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A4A60_03290	COG0802	atpase or kinase
A4A60_03295	COG1214	PFAM Peptidase M22, glycoprotease
A4A60_03300	COG0456	acetyltransferase
A4A60_03305	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A4A60_03310	COG0488	(ABC) transporter
A4A60_03315	COG0315	cyclic pyranopterin monophosphate synthase activity
A4A60_03320	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A4A60_03325	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4A60_03330	COG0805	protein transport
A4A60_03340	COG1266	CAAX protease self-immunity
A4A60_03345	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A4A60_03350	COG0459	protein refolding
A4A60_03355	COG4974	Belongs to the 'phage' integrase family
A4A60_03360	COG2856	Zn peptidase
A4A60_03365	COG1396	sequence-specific DNA binding
A4A60_03425	COG3935	DnaD domain protein
A4A60_03430	COG1484	DNA-dependent DNA replication
A4A60_03440	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
A4A60_03480	COG3677	Transposase
A4A60_03565	COG5280	Phage tail tape measure protein TP901
A4A60_03565	COG3953	SLT domain
A4A60_03575	COG1705	Flagellar rod assembly protein muramidase FlgJ
A4A60_03605	COG3409	Peptidoglycan-binding domain 1 protein
A4A60_03605	COG5632	N-Acetylmuramoyl-L-alanine amidase
A4A60_03605	COG1388	LysM domain
A4A60_03615	COG5444	nuclease activity
A4A60_03665	COG0457	Tetratricopeptide repeat
A4A60_03670	COG1063	alcohol dehydrogenase
A4A60_03675	COG2211	Major facilitator Superfamily
A4A60_03680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4A60_03685	COG1842	Phage shock protein A
A4A60_03690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A4A60_03695	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
A4A60_03700	COG4260	virion core protein, lumpy skin disease virus
A4A60_03710	COG2814	Major facilitator Superfamily
A4A60_03715	COG1063	alcohol dehydrogenase
A4A60_03720	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A4A60_03725	COG0823	Involved in the tonB-independent uptake of proteins
A4A60_03735	COG2801	Transposase and inactivated derivatives
A4A60_03750	COG2267	carboxylic ester hydrolase activity
A4A60_03760	COG2132	Multicopper oxidase
A4A60_03765	COG1113	amino acid transport
A4A60_03775	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A4A60_03780	COG0714	Associated with various cellular activities
A4A60_03785	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
A4A60_03790	COG1305	Transglutaminase-like
A4A60_03795	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A4A60_03795	COG0519	Catalyzes the synthesis of GMP from XMP
A4A60_03810	COG2252	PERMEase
A4A60_03815	COG3064	Membrane
A4A60_03830	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
A4A60_03840	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A4A60_03845	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A4A60_03850	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4A60_03855	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A4A60_03860	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A4A60_03865	COG0047	phosphoribosylformylglycinamidine synthase activity
A4A60_03870	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A4A60_03875	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A4A60_03880	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A4A60_03885	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A4A60_03890	COG0138	bifunctional purine biosynthesis protein purh
A4A60_03895	COG0151	Belongs to the GarS family
A4A60_03900	COG1522	sequence-specific DNA binding
A4A60_03915	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A4A60_03920	COG1470	cell adhesion involved in biofilm formation
A4A60_03925	COG4496	protein, YerC YecD
A4A60_03930	COG0069	glutamate synthase activity
A4A60_03940	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
A4A60_03945	COG0210	DNA helicase
A4A60_03950	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A4A60_03955	COG4851	CamS sex pheromone cAM373 precursor
A4A60_03960	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A4A60_03965	COG1285	pathogenesis
A4A60_03970	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4A60_03975	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A4A60_03980	COG0154	amidase activity
A4A60_03985	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A4A60_03990	COG1309	transcriptional regulator
A4A60_03995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
A4A60_04000	COG1597	lipid kinase activity
A4A60_04005	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4A60_04030	COG0457	Tetratricopeptide repeat
A4A60_04050	COG5444	nuclease activity
A4A60_04060	COG3586	endonuclease activity
A4A60_04070	COG0457	Tetratricopeptide repeat
A4A60_04080	COG0217	transcriptional regulatory protein
A4A60_04090	COG1309	transcriptional regulator
A4A60_04095	COG3631	Ketosteroid isomerase-related protein
A4A60_04100	COG0702	epimerase
A4A60_04115	COG3546	catalase activity
A4A60_04120	COG0454	-acetyltransferase
A4A60_04130	COG5578	integral membrane protein
A4A60_04135	COG2972	Histidine kinase
A4A60_04145	COG1653	transport
A4A60_04155	COG0395	ABC-type sugar transport system, permease component
A4A60_04160	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A4A60_04165	COG2207	Transcriptional regulator
A4A60_04170	COG2755	lipolytic protein G-D-S-L family
A4A60_04180	COG5578	integral membrane protein
A4A60_04190	COG3401	FG-GAP repeat protein
A4A60_04195	COG2755	lipolytic protein G-D-S-L family
A4A60_04200	COG1874	Beta-galactosidase
A4A60_04210	COG1653	transport
A4A60_04215	COG4209	transmembrane transport
A4A60_04220	COG0395	ABC-type sugar transport system, permease component
A4A60_04225	COG1486	melibiose metabolic process
A4A60_04230	COG2323	membrane
A4A60_04235	COG2329	Antibiotic biosynthesis monooxygenase
A4A60_04240	COG0346	lactoylglutathione lyase activity
A4A60_04255	COG5583	Uncharacterized small protein (DUF2292)
A4A60_04260	COG0670	Belongs to the BI1 family
A4A60_04265	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4A60_04270	COG1715	Restriction endonuclease
A4A60_04280	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A4A60_04280	COG2124	cytochrome p450
A4A60_04285	COG1368	sulfuric ester hydrolase activity
A4A60_04290	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A4A60_04295	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4A60_04300	COG1442	glycosyl transferase family 8
A4A60_04305	COG1216	Glycosyl transferase, family 2
A4A60_04310	COG1442	glycosyl transferase family 8
A4A60_04315	COG2223	nitrite transmembrane transporter activity
A4A60_04320	COG1011	Hydrolase
A4A60_04325	COG0531	amino acid
A4A60_04330	COG1012	belongs to the aldehyde dehydrogenase family
A4A60_04335	COG0840	transmembrane signaling receptor activity
A4A60_04340	COG0488	(ABC) transporter
A4A60_04350	COG0789	Transcriptional regulator
A4A60_04355	COG2814	Major facilitator Superfamily
A4A60_04370	COG2801	Transposase and inactivated derivatives
A4A60_04375	COG0488	(ABC) transporter
A4A60_04380	COG0513	Belongs to the DEAD box helicase family
A4A60_04385	COG0456	acetyltransferase
A4A60_04390	COG3328	transposase activity
A4A60_04395	COG2130	NADP-dependent
A4A60_04400	COG1120	ATPase activity
A4A60_04405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4A60_04410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4A60_04415	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A4A60_04430	COG3866	Pectate lyase
A4A60_04435	COG0471	metal ion transport
A4A60_04440	COG3290	protein histidine kinase activity
A4A60_04445	COG4565	transcriptional regulatory protein
A4A60_04450	COG3181	Tripartite tricarboxylate transporter family receptor
A4A60_04460	COG2851	Citrate transporter
A4A60_04465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4A60_04470	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
A4A60_04475	COG1254	Belongs to the acylphosphatase family
A4A60_04480	COG2258	MOSC domain
A4A60_04500	COG0024	Methionine aminopeptidase
A4A60_04505	COG1263	PTS System
A4A60_04505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4A60_04510	COG1368	sulfuric ester hydrolase activity
A4A60_04520	COG0697	spore germination
A4A60_04525	COG1263	PTS System
A4A60_04525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4A60_04530	COG0366	Alpha amylase catalytic
A4A60_04535	COG2188	Transcriptional regulator
A4A60_04540	COG0778	Nitroreductase
A4A60_04545	COG0737	Belongs to the 5'-nucleotidase family
A4A60_04550	COG0693	protein deglycase activity
A4A60_04555	COG2814	Major facilitator Superfamily
A4A60_04560	COG4840	Belongs to the UPF0435 family
A4A60_04565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4A60_04570	COG4980	gas vesicle protein
A4A60_04575	COG1295	ribonuclease BN
A4A60_04585	COG0477	Major facilitator Superfamily
A4A60_04595	COG0387	Pfam Sodium calcium exchanger
A4A60_04605	COG0668	transmembrane transport
A4A60_04610	COG0535	radical SAM domain protein
A4A60_04620	COG0726	polysaccharide deacetylase
A4A60_04625	COG2084	Dehydrogenase
A4A60_04630	COG0598	Magnesium transport protein CorA
A4A60_04635	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A4A60_04640	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4A60_04650	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4A60_04655	COG4637	Psort location Cytoplasmic, score
A4A60_04665	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A4A60_04670	COG0022	dehydrogenase e1 component
A4A60_04675	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4A60_04680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4A60_04685	COG3284	Transcriptional regulator
A4A60_04695	COG1742	UPF0060 membrane protein
A4A60_04720	COG4842	Belongs to the WXG100 family
A4A60_04725	COG1486	melibiose metabolic process
A4A60_04730	COG1737	Transcriptional regulator
A4A60_04735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4A60_04735	COG1263	PTS System
A4A60_04740	COG1132	(ABC) transporter
A4A60_04745	COG1132	(ABC) transporter
A4A60_04750	COG2259	Doxx family
A4A60_04755	COG2514	catechol 2,3-dioxygenase activity
A4A60_04760	COG4585	Histidine kinase
A4A60_04765	COG2197	response regulator
A4A60_04770	COG1131	(ABC) transporter
A4A60_04775	COG1511	domain protein
A4A60_04775	COG0842	Transport permease protein
A4A60_04780	COG0842	Transport permease protein
A4A60_04785	COG1695	Transcriptional regulator
A4A60_04790	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
A4A60_04795	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
A4A60_04800	COG1309	transcriptional regulator
A4A60_04805	COG2814	Major facilitator Superfamily
A4A60_04810	COG2318	DinB family
A4A60_04820	COG1846	Transcriptional regulator
A4A60_04825	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A4A60_04825	COG0392	lysyltransferase activity
A4A60_04830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4A60_04835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4A60_04840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4A60_04845	COG0384	phenazine biosynthesis protein PhzF
A4A60_04850	COG0778	Nitroreductase
A4A60_04865	COG1090	epimerase
A4A60_04870	COG2137	regulation of response to DNA damage stimulus
A4A60_04885	COG2814	Major facilitator Superfamily
A4A60_04900	COG3103	Sh3 type 3 domain protein
A4A60_04905	COG5658	integral membrane protein
A4A60_04910	COG0596	Alpha beta hydrolase
A4A60_04915	COG0463	Glycosyl transferase, family 2
A4A60_04920	COG4485	Bacterial membrane protein, YfhO
A4A60_04925	COG1988	membrane-bound metal-dependent
A4A60_04930	COG1194	a g-specific adenine glycosylase
A4A60_04940	COG1028	Short-chain dehydrogenase reductase Sdr
A4A60_04955	COG3557	Belongs to the UPF0374 family
A4A60_04960	COG1132	(ABC) transporter
A4A60_04965	COG4129	membrane
A4A60_04970	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A4A60_04975	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A4A60_04980	COG0735	belongs to the Fur family
A4A60_05100	COG2801	Transposase and inactivated derivatives
A4A60_05110	COG4326	sporulation control protein
A4A60_05120	COG5577	PFAM Coat F domain
A4A60_05125	COG3340	Belongs to the peptidase S51 family
A4A60_05130	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A4A60_05145	COG0753	catalase activity
A4A60_05150	COG1116	anion transmembrane transporter activity
A4A60_05155	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4A60_05160	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4A60_05165	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4A60_05175	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A4A60_05185	COG1476	TRANSCRIPTIONal
A4A60_05195	COG3382	B3 4 domain protein
A4A60_05200	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A4A60_05210	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A4A60_05215	COG0789	Transcriptional regulator
A4A60_05220	COG1664	Polymer-forming cytoskeletal
A4A60_05225	COG1664	Polymer-forming cytoskeletal
A4A60_05230	COG2766	serine protein kinase
A4A60_05235	COG2718	Belongs to the UPF0229 family
A4A60_05245	COG1846	Transcriptional regulator
A4A60_05250	COG1566	PFAM secretion protein HlyD family protein
A4A60_05255	COG2814	Major facilitator Superfamily
A4A60_05260	COG0655	NAD(P)H dehydrogenase (quinone) activity
A4A60_05275	COG1725	Transcriptional regulator
A4A60_05280	COG1131	(ABC) transporter
A4A60_05285	COG1131	(ABC) transporter
A4A60_05290	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A4A60_05295	COG1278	Cold shock
A4A60_05300	COG1464	Belongs to the NlpA lipoprotein family
A4A60_05305	COG3706	GGDEF domain
A4A60_05310	COG1823	symporter activity
A4A60_05315	COG5444	nuclease activity
A4A60_05340	COG0582	viral genome integration into host DNA
A4A60_05395	COG0791	NLP P60 protein
A4A60_05395	COG0741	lytic transglycosylase activity
A4A60_05415	COG0457	Tetratricopeptide repeat
A4A60_05435	COG5577	PFAM Coat F domain
A4A60_05440	COG4085	toxin activity
A4A60_05440	COG1525	nuclease
A4A60_05440	COG0737	Belongs to the 5'-nucleotidase family
A4A60_05445	COG3764	Sortase (surface protein transpeptidase)
A4A60_05450	COG0564	pseudouridine synthase activity
A4A60_05460	COG0517	IMP dehydrogenase activity
A4A60_05465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4A60_05470	COG3153	acetyltransferase
A4A60_05470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4A60_05475	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A4A60_05480	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
A4A60_05485	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A4A60_05490	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A4A60_05495	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A4A60_05500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4A60_05505	COG4585	Histidine kinase
A4A60_05505	COG2203	Gaf domain
A4A60_05510	COG2197	response regulator
A4A60_05515	COG0431	NADPH-dependent FMN reductase
A4A60_05530	COG0791	NLP P60 protein
A4A60_05530	COG1388	LysM domain
A4A60_05535	COG1959	2 iron, 2 sulfur cluster binding
A4A60_05545	COG0668	transmembrane transport
A4A60_05550	COG2719	SpoVR family
A4A60_05555	COG1785	Belongs to the alkaline phosphatase family
A4A60_05560	COG1388	LysM domain
A4A60_05560	COG0791	NLP P60 protein
A4A60_05565	COG0583	DNA-binding transcription factor activity
A4A60_05570	COG0372	Belongs to the citrate synthase family
A4A60_05575	COG1028	Short-chain dehydrogenase reductase Sdr
A4A60_05580	COG0531	amino acid
A4A60_05585	COG0733	neurotransmitter:sodium symporter activity
A4A60_05590	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4A60_05595	COG0456	acetyltransferase
A4A60_05610	COG1595	DNA-templated transcription, initiation
A4A60_05615	COG0667	Aldo Keto reductase
A4A60_05620	COG0204	Acyl-transferase
A4A60_05625	COG1253	flavin adenine dinucleotide binding
A4A60_05630	COG0789	Transcriptional regulator
A4A60_05640	COG1253	flavin adenine dinucleotide binding
A4A60_05645	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A4A60_05650	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A4A60_05655	COG0584	glycerophosphoryl diester phosphodiesterase
A4A60_05665	COG0668	transmembrane transport
A4A60_05670	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A4A60_05675	COG0726	polysaccharide deacetylase
A4A60_05680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4A60_05685	COG1757	Na H antiporter
A4A60_05690	COG0589	response to stress
A4A60_05700	COG1132	(ABC) transporter
A4A60_05705	COG1132	(ABC) transporter
A4A60_05710	COG0702	epimerase
A4A60_05725	COG0189	ligase activity
A4A60_05730	COG0189	ligase activity
A4A60_05735	COG4399	Belongs to the UPF0754 family
A4A60_05740	COG3679	Belongs to the UPF0342 family
A4A60_05750	COG0561	phosphatase activity
A4A60_05755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4A60_05760	COG0475	glutathione-regulated potassium exporter activity
A4A60_05765	COG0490	domain, Protein
A4A60_05775	COG1024	Enoyl-CoA hydratase
A4A60_05785	COG4152	abc transporter atp-binding protein
A4A60_05790	COG1668	transmembrane transport
A4A60_05795	COG0420	3'-5' exonuclease activity
A4A60_05800	COG4717	serine-type aminopeptidase activity
A4A60_05805	COG3481	metal-dependent phosphohydrolase, HD sub domain
A4A60_05815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4A60_05835	COG1846	Transcriptional regulator
A4A60_05840	COG4980	gas vesicle protein
A4A60_05855	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A4A60_05860	COG0537	adenosine 5'-monophosphoramidase activity
A4A60_05865	COG1131	(ABC) transporter
A4A60_05870	COG4473	ABC transporter
A4A60_05880	COG1473	amidohydrolase
A4A60_05885	COG3069	C4-dicarboxylate transmembrane transporter activity
A4A60_05895	COG2329	Antibiotic biosynthesis monooxygenase
A4A60_05900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4A60_05905	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A4A60_05920	COG1309	transcriptional regulator
A4A60_05925	COG1511	domain protein
A4A60_05935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4A60_05940	COG4377	Putative membrane peptidase family (DUF2324)
A4A60_05950	COG1363	Peptidase, m42
A4A60_05955	COG4405	Protein conserved in bacteria
A4A60_05960	COG1301	dicarboxylic acid transport
A4A60_05970	COG1234	tRNA 3'-trailer cleavage
A4A60_05975	COG0095	Lipoate-protein ligase
A4A60_05980	COG0702	epimerase
A4A60_05985	COG0318	PFAM AMP-dependent synthetase and ligase
A4A60_06000	COG0501	Belongs to the peptidase M48B family
A4A60_06010	COG0456	acetyltransferase
A4A60_06015	COG0604	alcohol dehydrogenase
A4A60_06020	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
A4A60_06025	COG2801	Transposase and inactivated derivatives
A4A60_06035	COG0406	alpha-ribazole phosphatase activity
A4A60_06040	COG0183	Belongs to the thiolase family
A4A60_06045	COG0318	PFAM AMP-dependent synthetase and ligase
A4A60_06050	COG1268	BioY protein
A4A60_06055	COG0840	transmembrane signaling receptor activity
A4A60_06065	COG1028	Short-chain dehydrogenase reductase Sdr
A4A60_06075	COG4903	ComK protein
A4A60_06080	COG1028	Short-chain dehydrogenase reductase Sdr
A4A60_06090	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4A60_06105	COG0398	Pfam SNARE associated Golgi protein
A4A60_06110	COG0681	Belongs to the peptidase S26 family
A4A60_06115	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
A4A60_06120	COG1846	Transcriptional regulator
A4A60_06135	COG0738	Major facilitator superfamily
A4A60_06140	COG0673	inositol 2-dehydrogenase activity
A4A60_06145	COG0561	phosphatase activity
A4A60_06150	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4A60_06155	COG1609	Transcriptional regulator
A4A60_06160	COG3180	Ammonia monooxygenase
A4A60_06165	COG0477	Major facilitator Superfamily
A4A60_06165	COG2814	Major facilitator Superfamily
A4A60_06170	COG4533	DNA binding
A4A60_06180	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
A4A60_06185	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A4A60_06190	COG1074	ATP-dependent DNA helicase activity
A4A60_06195	COG0420	3'-5' exonuclease activity
A4A60_06200	COG0419	ATPase involved in DNA repair
A4A60_06205	COG1403	HNH endonuclease
A4A60_06250	COG5337	Spore coat protein CotH
A4A60_06255	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4A60_06265	COG1404	Belongs to the peptidase S8 family
A4A60_06280	COG0367	asparagine synthase
A4A60_06290	COG0534	Mate efflux family protein
A4A60_06295	COG1917	Cupin 2, conserved barrel domain protein
A4A60_06295	COG2207	Transcriptional regulator
A4A60_06300	COG1609	Transcriptional regulator
A4A60_06305	COG0673	inositol 2-dehydrogenase activity
A4A60_06310	COG2318	DinB family
A4A60_06315	COG1279	arginine transmembrane transporter activity
A4A60_06320	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4A60_06325	COG1357	PFAM Pentapeptide repeats (8 copies)
A4A60_06330	COG2267	carboxylic ester hydrolase activity
A4A60_06340	COG2153	protein acetylation
A4A60_06345	COG0646	methionine synthase
A4A60_06345	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A4A60_06350	COG1666	GTP binding
A4A60_06355	COG2996	Protein conserved in bacteria
A4A60_06375	COG1695	Transcriptional regulator
A4A60_06390	COG3227	Zinc metalloprotease (Elastase)
A4A60_06395	COG1307	EDD domain protein, DegV family
A4A60_06400	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4A60_06420	COG0561	phosphatase activity
A4A60_06425	COG1073	alpha beta
A4A60_06430	COG2151	metal-sulfur cluster biosynthetic enzyme
A4A60_06440	COG0277	FAD linked oxidase domain protein
A4A60_06450	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A4A60_06465	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4A60_06470	COG0505	Belongs to the CarA family
A4A60_06475	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A4A60_06480	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A4A60_06485	COG2801	Transposase and inactivated derivatives
A4A60_06505	COG2267	carboxylic ester hydrolase activity
A4A60_06515	COG1744	ABC transporter substrate-binding protein PnrA-like
A4A60_06530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4A60_06535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4A60_06540	COG5504	Zn-dependent protease
A4A60_06545	COG0444	Belongs to the ABC transporter superfamily
A4A60_06550	COG4608	Belongs to the ABC transporter superfamily
A4A60_06560	COG0601	transmembrane transport
A4A60_06565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4A60_06575	COG0180	Tryptophanyl-tRNA synthetase
A4A60_06580	COG4166	transmembrane transport
A4A60_06585	COG0601	transmembrane transport
A4A60_06590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4A60_06595	COG0444	Belongs to the ABC transporter superfamily
A4A60_06600	COG4608	Belongs to the ABC transporter superfamily
A4A60_06605	COG2814	Major facilitator Superfamily
A4A60_06615	COG1393	Belongs to the ArsC family
A4A60_06620	COG0861	Integral membrane protein TerC family
A4A60_06625	COG4862	establishment of competence for transformation
A4A60_06630	COG4469	Competence protein
A4A60_06635	COG1164	Oligoendopeptidase f
A4A60_06655	COG2346	COG2346, Truncated hemoglobins
A4A60_06660	COG0741	lytic transglycosylase activity
A4A60_06665	COG4116	CYTH
A4A60_06675	COG2357	RelA SpoT domain protein
A4A60_06680	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A4A60_06685	COG0564	pseudouridine synthase activity
A4A60_06690	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A4A60_06695	COG0475	glutathione-regulated potassium exporter activity
A4A60_06695	COG0569	domain protein
A4A60_06700	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A4A60_06705	COG0352	thiamine-phosphate diphosphorylase activity
A4A60_06710	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4A60_06715	COG2104	thiamine diphosphate biosynthetic process
A4A60_06720	COG2022	thiamine diphosphate biosynthetic process
A4A60_06725	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4A60_06730	COG0351	phosphomethylpyrimidine kinase
A4A60_06735	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A4A60_06795	COG0210	DNA helicase
A4A60_06805	COG2153	protein acetylation
A4A60_06810	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A4A60_06815	COG2382	esterase
A4A60_06820	COG0626	cystathionine gamma-synthase activity
A4A60_06825	COG0626	cystathionine gamma-synthase activity
A4A60_06830	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4A60_06835	COG5505	Protein of unknown function (DUF819)
A4A60_06865	COG1396	sequence-specific DNA binding
A4A60_06990	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A4A60_07000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4A60_07000	COG3711	transcriptional antiterminator
A4A60_07005	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4A60_07005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4A60_07005	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4A60_07010	COG1482	cell wall glycoprotein biosynthetic process
A4A60_07025	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4A60_07035	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4A60_07050	COG0109	protoheme IX farnesyltransferase activity
A4A60_07060	COG0726	polysaccharide deacetylase
A4A60_07085	COG2205	protein histidine kinase activity
A4A60_07095	COG3383	formate dehydrogenase (NAD+) activity
A4A60_07100	COG2427	Protein of unknown function (DUF1641)
A4A60_07110	COG1051	belongs to the nudix hydrolase family
A4A60_07125	COG2124	cytochrome p450
A4A60_07130	COG1819	glycosyl
A4A60_07140	COG1587	Uroporphyrinogen-III synthase
A4A60_07155	COG0390	transport system, permease component
A4A60_07160	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4A60_07165	COG0697	spore germination
A4A60_07180	COG1252	NADH dehydrogenase
A4A60_07185	COG1904	glucuronate isomerase
A4A60_07195	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
A4A60_07200	COG1063	alcohol dehydrogenase
A4A60_07205	COG1312	Catalyzes the dehydration of D-mannonate
A4A60_07210	COG1028	Short-chain dehydrogenase reductase Sdr
A4A60_07215	COG2271	Major facilitator Superfamily
A4A60_07220	COG1609	Transcriptional regulator
A4A60_07225	COG0246	Mannitol dehydrogenase
A4A60_07230	COG2721	sulfolactate sulfo-lyase activity
A4A60_07235	COG0730	response to heat
A4A60_07245	COG2318	DinB family
A4A60_07250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4A60_07255	COG2801	Transposase and inactivated derivatives
A4A60_07265	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4A60_07270	COG0457	Tetratricopeptide repeat
A4A60_07285	COG1388	LysM domain
A4A60_07285	COG5632	N-Acetylmuramoyl-L-alanine amidase
A4A60_07285	COG3409	Peptidoglycan-binding domain 1 protein
A4A60_07295	COG4195	phage-related replication protein
A4A60_07300	COG3546	catalase activity
A4A60_07305	COG2856	Zn peptidase
A4A60_07310	COG1396	sequence-specific DNA binding
A4A60_07320	COG1522	sequence-specific DNA binding
A4A60_07325	COG1484	DNA-dependent DNA replication
A4A60_07350	COG1595	DNA-templated transcription, initiation
A4A60_07355	COG3728	DNA packaging
A4A60_07355	COG5484	DNA packaging
A4A60_07360	COG1783	phage Terminase large subunit
A4A60_07365	COG5518	Phage portal protein
A4A60_07370	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A4A60_07375	COG4653	Phage capsid family
A4A60_07425	COG5412	phage tail tape measure protein
A4A60_07425	COG5412	phage tail tape measure protein
A4A60_07425	COG3953	SLT domain
A4A60_07425	COG5412	phage tail tape measure protein
A4A60_07425	COG3953	SLT domain
A4A60_07425	COG3953	SLT domain
A4A60_07430	COG1652	LysM domain
A4A60_07435	COG4193	domain, Protein
A4A60_07445	COG3628	GPW Gp25 family protein
A4A60_07450	COG3299	homolog of phage Mu protein gp47
A4A60_07455	COG3778	Protein conserved in bacteria
A4A60_07495	COG3409	Peptidoglycan-binding domain 1 protein
A4A60_07495	COG5632	N-Acetylmuramoyl-L-alanine amidase
A4A60_07510	COG0306	phosphate transporter
A4A60_07515	COG1392	Phosphate transport regulator
A4A60_07525	COG0531	amino acid
A4A60_07530	COG0346	lactoylglutathione lyase activity
A4A60_07535	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A4A60_07540	COG0463	Glycosyl transferase, family 2
A4A60_07550	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4A60_07555	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A4A60_07560	COG2362	D-Aminopeptidase
A4A60_07565	COG0601	transmembrane transport
A4A60_07570	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4A60_07575	COG0444	Belongs to the ABC transporter superfamily
A4A60_07580	COG4166	transmembrane transport
A4A60_07585	COG1619	proteins homologs of microcin C7 resistance protein MccF
A4A60_07590	COG4948	Mandelate Racemase Muconate Lactonizing
A4A60_07595	COG0791	NLP P60 protein
A4A60_07600	COG4608	Belongs to the ABC transporter superfamily
A4A60_07605	COG2706	6-phosphogluconolactonase activity
A4A60_07615	COG1607	acyl-coa hydrolase
A4A60_07620	COG1017	nitric oxide dioxygenase activity
A4A60_07620	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4A60_07630	COG2323	membrane
A4A60_07635	COG2318	DinB family
A4A60_07640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4A60_07645	COG2076	Multidrug Resistance protein
A4A60_07650	COG2076	Multidrug Resistance protein
A4A60_07655	COG0788	formyltetrahydrofolate deformylase activity
A4A60_07660	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A4A60_07665	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A4A60_07670	COG1764	response to oxidative stress
A4A60_07675	COG1846	Transcriptional regulator
A4A60_07680	COG1764	response to oxidative stress
A4A60_07690	COG0590	tRNA wobble adenosine to inosine editing
A4A60_07695	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A4A60_07700	COG1404	Belongs to the peptidase S8 family
A4A60_07705	COG1366	Belongs to the anti-sigma-factor antagonist family
A4A60_07710	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
A4A60_07715	COG1122	ATPase activity
A4A60_07720	COG4721	ABC-type cobalt transport system, permease component
A4A60_07730	COG0745	RESPONSE REGULATOR receiver
A4A60_07735	COG5002	protein histidine kinase activity
A4A60_07735	COG3850	Histidine kinase
A4A60_07740	COG3212	peptidase
A4A60_07745	COG3212	peptidase
A4A60_07765	COG2239	Acts as a magnesium transporter
A4A60_07770	COG0789	Transcriptional regulator
A4A60_07785	COG1846	Transcriptional regulator
A4A60_07790	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A4A60_07795	COG0726	polysaccharide deacetylase
A4A60_07800	COG1408	metallophosphoesterase
A4A60_07810	COG0463	Glycosyl transferase, family 2
A4A60_07815	COG3285	dna ligase
A4A60_07815	COG1793	dna ligase
A4A60_07820	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
A4A60_07825	COG3300	MHYT domain
A4A60_07825	COG5001	Diguanylate cyclase
A4A60_07830	COG0586	Pfam SNARE associated Golgi protein
A4A60_07835	COG0861	Integral membrane protein TerC family
A4A60_07840	COG1191	sigma factor activity
A4A60_07860	COG0501	Belongs to the peptidase M48B family
A4A60_07865	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4A60_07880	COG3594	Acyltransferase
A4A60_07885	COG5002	protein histidine kinase activity
A4A60_07890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A4A60_07900	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
A4A60_07905	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
A4A60_07910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4A60_07915	COG0436	Aminotransferase
A4A60_07920	COG1850	ribulose-bisphosphate carboxylase activity
A4A60_07925	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
A4A60_07930	COG0235	Class ii aldolase
A4A60_07935	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
A4A60_07940	COG3339	Conserved Protein
A4A60_07955	COG3852	Histidine kinase
A4A60_07960	COG1846	Transcriptional regulator
A4A60_07965	COG1360	Flagellar Motor Protein
A4A60_07970	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A4A60_07975	COG0542	response to heat
A4A60_07980	COG3949	Membrane
A4A60_07985	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A4A60_07990	COG0720	synthase
A4A60_07995	COG0602	queuosine metabolic process
A4A60_08000	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A4A60_08010	COG4873	Protein conserved in bacteria
A4A60_08025	COG3773	Cell wall hydrolase
A4A60_08030	COG2244	polysaccharide biosynthetic process
A4A60_08035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4A60_08040	COG2217	Heavy metal translocating P-type atpase
A4A60_08050	COG0006	proline dipeptidase activity
A4A60_08060	COG1609	Transcriptional regulator
A4A60_08065	COG3711	transcriptional antiterminator
A4A60_08070	COG1263	PTS System
A4A60_08070	COG2190	(PTS) system
A4A60_08070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4A60_08075	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4A60_08080	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4A60_08090	COG1533	DNA photolyase activity
A4A60_08095	COG0456	acetyltransferase
A4A60_08100	COG0840	transmembrane signaling receptor activity
A4A60_08105	COG2084	Dehydrogenase
A4A60_08120	COG3328	transposase activity
A4A60_08125	COG2340	Cysteine-rich secretory protein family
A4A60_08130	COG0768	penicillin binding
A4A60_08135	COG4191	Histidine kinase
A4A60_08140	COG0436	Aminotransferase
A4A60_08150	COG0784	Response regulator, receiver
A4A60_08150	COG0835	chemotaxis
A4A60_08160	COG2814	Major facilitator Superfamily
A4A60_08165	COG1376	ErfK ybiS ycfS ynhG family protein
A4A60_08170	COG1408	metallophosphoesterase
A4A60_08175	COG1028	Short-chain dehydrogenase reductase Sdr
A4A60_08180	COG2200	EAL domain
A4A60_08190	COG4703	Protein of unknown function (DUF1797)
A4A60_08195	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
A4A60_08205	COG0517	IMP dehydrogenase activity
A4A60_08210	COG0583	DNA-binding transcription factor activity
A4A60_08215	COG0716	FMN binding
A4A60_08225	COG0716	FMN binding
A4A60_08230	COG2171	N-acyltransferase activity
A4A60_08235	COG1473	amidohydrolase
A4A60_08245	COG0668	transmembrane transport
A4A60_08250	COG0450	alkyl hydroperoxide reductase
A4A60_08255	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4A60_08265	COG2801	Transposase and inactivated derivatives
A4A60_08280	COG0746	molybdenum cofactor guanylyltransferase activity
A4A60_08285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4A60_08290	COG0303	'Molybdopterin
A4A60_08295	COG1763	Mo-molybdopterin cofactor biosynthetic process
A4A60_08300	COG0314	molybdopterin synthase activity
A4A60_08305	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A4A60_08310	COG1132	(ABC) transporter
A4A60_08315	COG1132	(ABC) transporter
A4A60_08325	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4A60_08330	COG1136	(ABC) transporter
A4A60_08335	COG0577	efflux transmembrane transporter activity
A4A60_08340	COG1349	DNA-binding transcription factor activity
A4A60_08345	COG1105	Belongs to the carbohydrate kinase PfkB family
A4A60_08350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4A60_08350	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4A60_08350	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A4A60_08355	COG0681	Belongs to the peptidase S26 family
A4A60_08365	COG0488	(ABC) transporter
A4A60_08370	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A4A60_08380	COG2309	aminopeptidase activity
A4A60_08390	COG1077	Cell shape determining protein MreB Mrl
A4A60_08395	COG2002	toxin-antitoxin pair type II binding
A4A60_08400	COG3852	Histidine kinase
A4A60_08405	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
A4A60_08405	COG2105	PFAM AIG2 family protein
A4A60_08410	COG0569	domain protein
A4A60_08415	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
A4A60_08420	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A4A60_08430	COG0561	phosphatase activity
A4A60_08435	COG0242	peptide deformylase activity
A4A60_08445	COG0497	DNA recombination
A4A60_08450	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A4A60_08455	COG0022	dehydrogenase e1 component
A4A60_08460	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4A60_08465	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4A60_08470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4A60_08485	COG1982	Orn Lys Arg decarboxylase major
A4A60_08490	COG4476	Belongs to the UPF0223 family
A4A60_08495	COG4493	Belongs to the UPF0637 family
A4A60_08505	COG0483	inositol monophosphate 1-phosphatase activity
A4A60_08515	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
A4A60_08570	COG4896	Protein conserved in bacteria
A4A60_08580	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A4A60_08585	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A4A60_08590	COG2066	Belongs to the glutaminase family
A4A60_08595	COG4838	Belongs to the UPF0358 family
A4A60_08600	COG0772	Belongs to the SEDS family
A4A60_08605	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A4A60_08615	COG1612	heme a metabolic process
A4A60_08620	COG0109	protoheme IX farnesyltransferase activity
A4A60_08625	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A4A60_08625	COG2010	Cytochrome c
A4A60_08630	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A4A60_08635	COG1845	cytochrome c oxidase, subunit III
A4A60_08640	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A4A60_08645	COG3336	cytochrome c oxidase
A4A60_08655	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
A4A60_08660	COG2340	Cysteine-rich secretory protein family
A4A60_08675	COG3679	Belongs to the UPF0342 family
A4A60_08680	COG4471	UPF0298 protein
A4A60_08685	COG0742	ribosomal rna small subunit methyltransferase
A4A60_08690	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A4A60_08695	COG3314	Sporulation integral membrane protein YlbJ
A4A60_08700	COG1752	Esterase of the alpha-beta hydrolase superfamily
A4A60_08705	COG3480	Lon protease (S16) C-terminal proteolytic domain
A4A60_08710	COG1323	Belongs to the UPF0348 family
A4A60_08720	COG1399	metal-binding, possibly nucleic acid-binding protein
A4A60_08725	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A4A60_08735	COG0454	-acetyltransferase
A4A60_08740	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A4A60_08745	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
A4A60_08750	COG2001	Belongs to the MraZ family
A4A60_08755	COG0275	rRNA processing
A4A60_08760	COG4839	cell division protein FtsL
A4A60_08775	COG0768	penicillin binding
A4A60_08785	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A4A60_08795	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4A60_08800	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A4A60_08805	COG0772	Belongs to the SEDS family
A4A60_08810	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A4A60_08815	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A4A60_08820	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A4A60_08825	COG3879	Bacterial protein of unknown function (DUF881)
A4A60_08830	COG3879	Bacterial protein of unknown function (DUF881)
A4A60_08835	COG3856	small basic protein
A4A60_08840	COG0849	cell division
A4A60_08845	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A4A60_08850	COG4412	M6 family metalloprotease domain protein
A4A60_08850	COG1404	Belongs to the peptidase S8 family
A4A60_08860	COG1191	sigma factor activity
A4A60_08865	COG1191	sigma factor activity
A4A60_08870	COG1119	ATPase activity
A4A60_08875	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4A60_08880	COG1873	PFAM PRC-barrel domain
A4A60_08890	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A4A60_08895	COG1799	cell septum assembly
A4A60_08900	COG0762	integral membrane protein
A4A60_08905	COG2302	S4 RNA-binding domain
A4A60_08910	COG3599	regulation of cell shape
A4A60_08915	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A4A60_08925	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A4A60_08930	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A4A60_08935	COG0564	pseudouridine synthase activity
A4A60_08940	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A4A60_08945	COG2233	PERMEase
A4A60_08950	COG0540	Belongs to the ATCase OTCase family
A4A60_08955	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4A60_08960	COG0505	Belongs to the CarA family
A4A60_08965	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A4A60_08970	COG0543	2 iron, 2 sulfur cluster binding
A4A60_08975	COG0167	dihydroorotate dehydrogenase activity
A4A60_08980	COG0284	orotidine-5'-phosphate decarboxylase activity
A4A60_08985	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A4A60_08990	COG0175	sulfate reduction
A4A60_08995	COG0306	phosphate transporter
A4A60_09000	COG2046	Belongs to the sulfate adenylyltransferase family
A4A60_09005	COG0529	Catalyzes the synthesis of activated sulfate
A4A60_09010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
A4A60_09015	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
A4A60_09020	COG1648	precorrin-2 dehydrogenase activity
A4A60_09030	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A4A60_09035	COG1561	YicC-like family, N-terminal region
A4A60_09040	COG2052	Domain of unknown function (DUF370)
A4A60_09045	COG0194	GDP metabolic process
A4A60_09050	COG1758	RNA polymerase activity
A4A60_09055	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A4A60_09060	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A4A60_09065	COG0242	peptide deformylase activity
A4A60_09070	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A4A60_09075	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4A60_09075	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A4A60_09080	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A4A60_09085	COG0631	protein serine/threonine phosphatase activity
A4A60_09090	COG0515	serine threonine protein kinase
A4A60_09090	COG2815	serine threonine protein kinase
A4A60_09095	COG1162	GTPase activity
A4A60_09100	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4A60_09105	COG1564	THIamine pyrophosphokinase
A4A60_09115	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A4A60_09120	COG1302	Protein conserved in bacteria
A4A60_09125	COG1461	Dihydroxyacetone kinase
A4A60_09130	COG1760	l-serine dehydratase
A4A60_09135	COG1760	l-serine dehydratase
A4A60_09140	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A4A60_09145	COG2050	protein possibly involved in aromatic compounds catabolism
A4A60_09145	COG1349	DNA-binding transcription factor activity
A4A60_09150	COG0416	fatty acid biosynthetic process
A4A60_09155	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A4A60_09160	COG1028	Short-chain dehydrogenase reductase Sdr
A4A60_09165	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4A60_09170	COG0571	ribonuclease III activity
A4A60_09175	COG1196	nuclear chromosome segregation
A4A60_09180	COG0552	protein localization to endoplasmic reticulum
A4A60_09190	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
A4A60_09195	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A4A60_09200	COG0228	four-way junction DNA binding
A4A60_09205	COG1837	Belongs to the UPF0109 family
A4A60_09215	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A4A60_09220	COG0336	Belongs to the RNA methyltransferase TrmD family
A4A60_09225	COG0335	large ribosomal subunit rRNA binding
A4A60_09230	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A4A60_09235	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A4A60_09245	COG2257	FlhB HrpN YscU SpaS Family
A4A60_09250	COG0045	succinate-CoA ligase (ADP-forming) activity
A4A60_09255	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A4A60_09260	COG0758	DNA mediated transformation
A4A60_09265	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4A60_09270	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A4A60_09275	COG4974	Belongs to the 'phage' integrase family
A4A60_09280	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A4A60_09285	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A4A60_09290	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A4A60_09295	COG1815	bacterial-type flagellum-dependent cell motility
A4A60_09300	COG1558	bacterial-type flagellum-dependent cell motility
A4A60_09305	COG1677	Flagellar hook-basal body complex protein FliE
A4A60_09310	COG1766	The M ring may be actively involved in energy transduction
A4A60_09315	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A4A60_09320	COG1317	bacterial-type flagellum organization
A4A60_09325	COG1157	protein secretion by the type III secretion system
A4A60_09330	COG2882	bacterial-type flagellum organization
A4A60_09335	COG3334	PFAM MgtE intracellular
A4A60_09340	COG3144	bacterial-type flagellum assembly
A4A60_09345	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A4A60_09350	COG4786	Flagellar basal body rod
A4A60_09355	COG1582	Flagellar protein (FlbD)
A4A60_09360	COG1580	Controls the rotational direction of flagella during chemotaxis
A4A60_09365	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A4A60_09370	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A4A60_09370	COG1776	CheC inhibitor of MCP methylation
A4A60_09375	COG2201	protein-glutamate methylesterase activity
A4A60_09380	COG3190	flagellar
A4A60_09385	COG1338	Plays a role in the flagellum-specific transport system
A4A60_09390	COG1987	bacterial-type flagellum assembly
A4A60_09395	COG1684	flagellar biosynthetic protein fliR
A4A60_09400	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A4A60_09405	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A4A60_09410	COG1419	protein localization to endoplasmic reticulum
A4A60_09415	COG0455	bacterial-type flagellum organization
A4A60_09420	COG2201	protein-glutamate methylesterase activity
A4A60_09425	COG2198	Histidine kinase
A4A60_09425	COG0643	Histidine kinase
A4A60_09430	COG0835	chemotaxis
A4A60_09435	COG1776	CheC inhibitor of MCP methylation
A4A60_09440	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
A4A60_09445	COG1191	sigma factor activity
A4A60_09455	COG0052	Belongs to the universal ribosomal protein uS2 family
A4A60_09460	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A4A60_09465	COG0528	UMP kinase activity
A4A60_09470	COG0233	cytoplasmic translational termination
A4A60_09475	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A4A60_09480	COG4589	Belongs to the CDS family
A4A60_09485	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A4A60_09490	COG0750	zinc metalloprotease
A4A60_09495	COG0442	prolyl-tRNA aminoacylation
A4A60_09500	COG2176	DNA-directed DNA polymerase activity
A4A60_09505	COG0779	Required for maturation of 30S ribosomal subunits
A4A60_09510	COG0195	Participates in both transcription termination and antitermination
A4A60_09515	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A4A60_09520	COG1358	cellular component organization or biogenesis
A4A60_09525	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A4A60_09530	COG1550	Protein conserved in bacteria
A4A60_09535	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A4A60_09540	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A4A60_09545	COG0196	riboflavin kinase activity
A4A60_09550	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A4A60_09555	COG1185	polyribonucleotide nucleotidyltransferase activity
A4A60_09560	COG0726	polysaccharide deacetylase
A4A60_09565	COG0612	Peptidase, M16
A4A60_09570	COG1873	PFAM PRC-barrel domain
A4A60_09580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4A60_09585	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A4A60_09590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A4A60_09595	COG0527	aspartate kinase activity
A4A60_09600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4A60_09605	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A4A60_09610	COG0740	serine-type endopeptidase activity
A4A60_09620	COG1674	ftsk spoiiie
A4A60_09620	COG4980	gas vesicle protein
A4A60_09625	COG2188	Transcriptional regulator
A4A60_09630	COG2814	Major facilitator Superfamily
A4A60_09635	COG0612	Peptidase, M16
A4A60_09640	COG0612	Peptidase, M16
A4A60_09645	COG0300	oxidoreductase activity
A4A60_09660	COG1426	Protein conserved in bacteria
A4A60_09665	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A4A60_09670	COG1546	Belongs to the CinA family
A4A60_09670	COG1058	Belongs to the CinA family
A4A60_09675	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A4A60_09680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A4A60_09685	COG1418	mRNA catabolic process
A4A60_09690	COG1692	metallophosphoesterase
A4A60_09695	COG2359	stage V sporulation protein S
A4A60_09700	COG1063	alcohol dehydrogenase
A4A60_09705	COG0156	8-amino-7-oxononanoate synthase activity
A4A60_09715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4A60_09720	COG4550	Control of competence regulator ComK, YlbF/YmcA
A4A60_09730	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A4A60_09735	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A4A60_09815	COG3328	transposase activity
A4A60_09840	COG3226	Transcriptional regulator
A4A60_09850	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4A60_09855	COG1404	Belongs to the peptidase S8 family
A4A60_09865	COG4195	phage-related replication protein
A4A60_09870	COG1764	response to oxidative stress
A4A60_09875	COG2076	Multidrug Resistance protein
A4A60_09880	COG2076	Multidrug Resistance protein
A4A60_09895	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A4A60_09900	COG1923	regulation of RNA biosynthetic process
A4A60_09915	COG1780	Probably involved in ribonucleotide reductase function
A4A60_09920	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4A60_09925	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4A60_09930	COG4112	unkown
A4A60_09935	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4A60_09940	COG0464	growth
A4A60_09950	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A4A60_09955	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
A4A60_09960	COG0789	Transcriptional regulator
A4A60_09965	COG0174	glutamine synthetase
A4A60_09980	COG5444	nuclease activity
A4A60_10010	COG4282	regulation of fungal-type cell wall biogenesis
A4A60_10020	COG3328	transposase activity
A4A60_10030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4A60_10045	COG3655	Transcriptional regulator
A4A60_10070	COG0135	phosphoribosylanthranilate isomerase activity
A4A60_10075	COG2211	Major facilitator Superfamily
A4A60_10080	COG3507	Belongs to the glycosyl hydrolase 43 family
A4A60_10085	COG1940	carbohydrate kinase activity
A4A60_10090	COG2115	Belongs to the xylose isomerase family
A4A60_10095	COG1070	Carbohydrate kinase
A4A60_10100	COG3328	transposase activity
A4A60_10105	COG1525	nuclease
A4A60_10110	COG2814	Major facilitator Superfamily
A4A60_10115	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4A60_10130	COG0756	dUTP diphosphatase activity
A4A60_10170	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4A60_10185	COG3832	glyoxalase III activity
A4A60_10230	COG4195	phage-related replication protein
A4A60_10240	COG0346	lactoylglutathione lyase activity
A4A60_10250	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A4A60_10255	COG1388	LysM domain
A4A60_10260	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A4A60_10265	COG4224	UPF0291 protein
A4A60_10270	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A4A60_10280	COG3763	UPF0154 protein
A4A60_10290	COG0785	Cytochrome C biogenesis protein
A4A60_10295	COG2201	protein-glutamate methylesterase activity
A4A60_10300	COG4846	Membrane protein involved in cytochrome C biogenesis
A4A60_10305	COG2801	Transposase and inactivated derivatives
A4A60_10320	COG0071	Belongs to the small heat shock protein (HSP20) family
A4A60_10335	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
A4A60_10340	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4A60_10360	COG0824	Thioesterase
A4A60_10370	COG4841	protein insertion into membrane
A4A60_10375	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A4A60_10380	COG1832	CoA-binding protein
A4A60_10385	COG0187	DNA topoisomerase II activity
A4A60_10390	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A4A60_10405	COG1115	amino acid carrier protein
A4A60_10410	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
A4A60_10430	COG2246	polysaccharide biosynthetic process
A4A60_10435	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A4A60_10440	COG0586	Pfam SNARE associated Golgi protein
A4A60_10445	COG2404	hydrolase activity, acting on ester bonds
A4A60_10450	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4A60_10455	COG1024	Enoyl-CoA hydratase
A4A60_10460	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4A60_10465	COG0511	ligase activity, forming carbon-carbon bonds
A4A60_10470	COG0439	Biotin carboxylase
A4A60_10475	COG0318	PFAM AMP-dependent synthetase and ligase
A4A60_10480	COG1960	acyl-CoA dehydrogenase activity
A4A60_10490	COG1649	PFAM Uncharacterised BCR, COG1649
A4A60_10505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4A60_10510	COG2027	D-alanyl-D-alanine carboxypeptidase
A4A60_10515	COG2017	converts alpha-aldose to the beta-anomer
A4A60_10520	COG0534	Mate efflux family protein
A4A60_10535	COG0582	viral genome integration into host DNA
A4A60_10540	COG0166	Belongs to the GPI family
A4A60_10545	COG0405	Gamma-glutamyltransferase
A4A60_10550	COG0583	DNA-binding transcription factor activity
A4A60_10555	COG0604	alcohol dehydrogenase
A4A60_10560	COG0493	'glutamate synthase
A4A60_10565	COG0067	glutamate synthase
A4A60_10565	COG0069	glutamate synthase activity
A4A60_10565	COG0070	glutamate synthase
A4A60_10570	COG0583	DNA-binding transcription factor activity
A4A60_10595	COG0300	oxidoreductase activity
A4A60_10600	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
A4A60_10610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4A60_10625	COG1131	(ABC) transporter
A4A60_10635	COG2814	Major facilitator Superfamily
A4A60_10650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4A60_10660	COG2323	membrane
A4A60_10675	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4A60_10690	COG3546	catalase activity
A4A60_10705	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4A60_10720	COG5278	phosphoserine phosphatase activity
A4A60_10720	COG0840	transmembrane signaling receptor activity
A4A60_10725	COG2368	4-hydroxyphenylacetate
A4A60_10730	COG4305	rare lipoprotein A
A4A60_10735	COG3619	membrane
A4A60_10755	COG2140	Oxalate decarboxylase
A4A60_10775	COG2720	vancomycin resistance protein
A4A60_10785	COG3655	Transcriptional regulator
A4A60_10790	COG3739	integral membrane protein
A4A60_10795	COG0583	DNA-binding transcription factor activity
A4A60_10800	COG0697	spore germination
A4A60_10810	COG0693	protein deglycase activity
A4A60_10815	COG2367	Beta-lactamase
A4A60_10835	COG3848	Pyruvate phosphate dikinase
A4A60_10835	COG0574	Belongs to the PEP-utilizing enzyme family
A4A60_10840	COG0726	polysaccharide deacetylase
A4A60_10845	COG2314	TM2 domain
A4A60_10850	COG1396	sequence-specific DNA binding
A4A60_10935	COG3655	Transcriptional regulator
A4A60_10980	COG0457	Tetratricopeptide repeat
A4A60_10985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4A60_10995	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4A60_11000	COG2226	methyltransferase
A4A60_11005	COG2211	Major facilitator Superfamily
A4A60_11015	COG3328	transposase activity
A4A60_11040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4A60_11060	COG5444	nuclease activity
A4A60_11065	COG4282	regulation of fungal-type cell wall biogenesis
A4A60_11070	COG1231	oxidoreductase activity
A4A60_11075	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4A60_11080	COG2207	Transcriptional regulator
A4A60_11080	COG0662	Cupin 2, conserved barrel domain protein
A4A60_11085	COG0456	acetyltransferase
A4A60_11090	COG1309	transcriptional regulator
A4A60_11095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4A60_11100	COG3708	Transcriptional regulator
A4A60_11105	COG2378	regulation of single-species biofilm formation
A4A60_11115	COG0640	Transcriptional regulator
A4A60_11120	COG0741	lytic transglycosylase activity
A4A60_11135	COG2322	membrane
A4A60_11150	COG1619	proteins homologs of microcin C7 resistance protein MccF
A4A60_11155	COG3239	Fatty acid desaturase
A4A60_11160	COG4585	Histidine kinase
A4A60_11165	COG2197	response regulator
A4A60_11170	COG3584	3D domain protein
A4A60_11170	COG1388	LysM domain
A4A60_11175	COG0514	ATP-dependent DNA helicase (RecQ)
A4A60_11190	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A4A60_11195	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A4A60_11210	COG0071	Belongs to the small heat shock protein (HSP20) family
A4A60_11240	COG1012	belongs to the aldehyde dehydrogenase family
A4A60_11245	COG1657	PFAM Prenyltransferase squalene oxidase
A4A60_11250	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A4A60_11255	COG0733	neurotransmitter:sodium symporter activity
A4A60_11260	COG0385	Bile acid
A4A60_11265	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4A60_11270	COG0567	Dehydrogenase, E1 component
A4A60_11275	COG4548	von Willebrand factor, type A
A4A60_11280	COG0714	Associated with various cellular activities
A4A60_11285	COG2032	superoxide dismutase activity
A4A60_11290	COG1388	LysM domain
A4A60_11290	COG0791	NLP P60 protein
A4A60_11295	COG1819	glycosyl
A4A60_11300	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A4A60_11305	COG0534	Mate efflux family protein
A4A60_11310	COG1366	Belongs to the anti-sigma-factor antagonist family
A4A60_11315	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A4A60_11320	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A4A60_11330	COG2962	Rard protein
A4A60_11345	COG2610	gluconate transmembrane transporter activity
A4A60_11350	COG1942	4-Oxalocrotonate Tautomerase
A4A60_11355	COG1733	regulation of RNA biosynthetic process
A4A60_11360	COG0778	Nitroreductase
A4A60_11365	COG0400	carboxylic ester hydrolase activity
A4A60_11370	COG0346	lactoylglutathione lyase activity
A4A60_11380	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4A60_11385	COG3409	Peptidoglycan-binding domain 1 protein
A4A60_11385	COG0793	Belongs to the peptidase S41A family
A4A60_11390	COG2226	methyltransferase
A4A60_11400	COG1876	peptidase activity
A4A60_11405	COG0813	purine-nucleoside phosphorylase activity
A4A60_11420	COG0671	phosphoesterase, PA-phosphatase related
A4A60_11445	COG4479	Belongs to the UPF0346 family
A4A60_11455	COG1509	lysine 2,3-aminomutase activity
A4A60_11460	COG0456	acetyltransferase
A4A60_11465	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4A60_11475	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A4A60_11480	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A4A60_11495	COG0456	acetyltransferase
A4A60_11500	COG0463	Glycosyl transferase, family 2
A4A60_11515	COG4641	Protein conserved in bacteria
A4A60_11520	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
A4A60_11525	COG1086	Polysaccharide biosynthesis protein
A4A60_11530	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A4A60_11535	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A4A60_11540	COG1846	Transcriptional regulator
A4A60_11545	COG0534	Mate efflux family protein
A4A60_11555	COG4698	Protein conserved in bacteria
A4A60_11560	COG2755	lipolytic protein G-D-S-L family
A4A60_11565	COG1999	signal sequence binding
A4A60_11580	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4A60_11585	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A4A60_11590	COG1272	protein, Hemolysin III
A4A60_11595	COG0204	Acyl-transferase
A4A60_11600	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A4A60_11605	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A4A60_11615	COG2136	Putative SAM-dependent methyltransferase
A4A60_11615	COG2521	methyltransferase
A4A60_11625	COG0129	dihydroxy-acid dehydratase activity
A4A60_11630	COG1413	lyase activity
A4A60_11635	COG1418	mRNA catabolic process
A4A60_11640	COG0386	Belongs to the glutathione peroxidase family
A4A60_11645	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A4A60_11650	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A4A60_11655	COG1278	Cold shock
A4A60_11675	COG0328	RNA-DNA hybrid ribonuclease activity
A4A60_11680	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
A4A60_11685	COG0328	RNA-DNA hybrid ribonuclease activity
A4A60_11695	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4A60_11715	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A4A60_11720	COG1755	Isoprenylcysteine carboxyl methyltransferase
A4A60_11730	COG2233	PERMEase
A4A60_11735	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4A60_11740	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A4A60_11750	COG0800	Aldolase
A4A60_11755	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4A60_11760	COG1609	Transcriptional regulator
A4A60_11765	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
A4A60_11770	COG1028	Short-chain dehydrogenase reductase Sdr
A4A60_11775	COG1199	ATP-dependent helicase activity
A4A60_11785	COG0116	Belongs to the methyltransferase superfamily
A4A60_11800	COG4474	Belongs to the UPF0398 family
A4A60_11810	COG3359	exonuclease
A4A60_11815	COG1205	dead DEAH box helicase
A4A60_11815	COG1111	helicase
A4A60_11820	COG2190	(PTS) system
A4A60_11825	COG0071	Belongs to the small heat shock protein (HSP20) family
A4A60_11860	COG3331	DNA recombination
A4A60_11865	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4A60_11865	COG4499	WXG100 protein secretion system (Wss), protein YukC
A4A60_11875	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A4A60_11880	COG3935	DnaD domain protein
A4A60_11885	COG0017	Asparaginyl-tRNA synthetase
A4A60_11890	COG0436	Aminotransferase
A4A60_11895	COG5353	protein conserved in bacteria
A4A60_11905	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A4A60_11905	COG1199	ATP-dependent helicase activity
A4A60_11910	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
A4A60_11915	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A4A60_11920	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A4A60_11925	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A4A60_11925	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A4A60_11930	COG0617	tRNA 3'-terminal CCA addition
A4A60_11935	COG0438	transferase activity, transferring glycosyl groups
A4A60_11940	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
A4A60_11945	COG1803	Methylglyoxal synthase
A4A60_11950	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A4A60_11955	COG1694	Mazg nucleotide pyrophosphohydrolase
A4A60_11960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4A60_11970	COG4347	Protein of unknown function (DUF1405)
A4A60_11975	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A4A60_11975	COG2010	Cytochrome c
A4A60_11980	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A4A60_11985	COG0723	plastoquinol--plastocyanin reductase activity
A4A60_11995	COG5582	Belongs to the UPF0302 family
A4A60_12000	COG0457	Tetratricopeptide repeat
A4A60_12005	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A4A60_12010	COG0287	Prephenate dehydrogenase
A4A60_12025	COG0133	tryptophan synthase activity
A4A60_12030	COG0135	phosphoribosylanthranilate isomerase activity
A4A60_12040	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A4A60_12045	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A4A60_12050	COG4401	Chorismate mutase type I
A4A60_12055	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A4A60_12060	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A4A60_12065	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A4A60_12075	COG0105	UTP biosynthetic process
A4A60_12080	COG0142	geranyltranstransferase activity
A4A60_12085	COG2226	methyltransferase
A4A60_12090	COG0142	geranyltranstransferase activity
A4A60_12100	COG0302	gtp cyclohydrolase
A4A60_12115	COG0776	regulation of translation
A4A60_12120	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
A4A60_12135	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A4A60_12140	COG1160	GTP binding
A4A60_12165	COG2801	Transposase and inactivated derivatives
A4A60_12175	COG1304	FMN binding
A4A60_12180	COG0539	negative regulation of cytoplasmic translation
A4A60_12185	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A4A60_12195	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
A4A60_12200	COG2959	enzyme of heme biosynthesis
A4A60_12205	COG3773	Cell wall hydrolase
A4A60_12205	COG3409	Peptidoglycan-binding domain 1 protein
A4A60_12210	COG2339	peptidase activity
A4A60_12215	COG0492	ferredoxin-NADP+ reductase activity
A4A60_12220	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4A60_12225	COG4862	establishment of competence for transformation
A4A60_12230	COG1408	metallophosphoesterase
A4A60_12240	COG1388	LysM domain
A4A60_12245	COG1266	CAAX protease self-immunity
A4A60_12250	COG0514	ATP-dependent DNA helicase (RecQ)
A4A60_12255	COG4955	Helix-turn-helix domain
A4A60_12260	COG1141	Ferredoxin
A4A60_12265	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A4A60_12270	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A4A60_12275	COG0710	3-dehydroquinate dehydratase activity
A4A60_12285	COG1595	DNA-templated transcription, initiation
A4A60_12290	COG5002	protein histidine kinase activity
A4A60_12295	COG0745	RESPONSE REGULATOR receiver
A4A60_12300	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4A60_12305	COG1333	cytochrome c biogenesis protein
A4A60_12310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4A60_12315	COG1187	pseudouridine synthase activity
A4A60_12320	COG0700	Nucleoside recognition
A4A60_12325	COG2715	membrane protein required for spore maturation
A4A60_12330	COG1686	Belongs to the peptidase S11 family
A4A60_12340	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A4A60_12345	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A4A60_12350	COG1547	Domain of unknown function (DUF309)
A4A60_12355	COG0456	acetyltransferase
A4A60_12360	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A4A60_12365	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4A60_12365	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4A60_12370	COG0307	riboflavin synthase, alpha
A4A60_12375	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4A60_12375	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4A60_12385	COG0681	Belongs to the peptidase S26 family
A4A60_12390	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
A4A60_12405	COG2433	Pfam Transposase IS66
A4A60_12435	COG3328	transposase activity
A4A60_12485	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4A60_12495	COG4086	secreted protein
A4A60_12500	COG0019	diaminopimelate decarboxylase activity
A4A60_12505	COG0697	spore germination
A4A60_12520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4A60_12540	COG1191	sigma factor activity
A4A60_12545	COG2172	sigma factor antagonist activity
A4A60_12550	COG1366	Belongs to the anti-sigma-factor antagonist family
A4A60_12555	COG1686	Belongs to the peptidase S11 family
A4A60_12560	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
A4A60_12565	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A4A60_12570	COG4974	Belongs to the 'phage' integrase family
A4A60_12580	COG0735	belongs to the Fur family
A4A60_12585	COG1300	Membrane
A4A60_12595	COG0281	malic enzyme
A4A60_12600	COG1757	Na H antiporter
A4A60_12605	COG1027	Aspartate ammonia-lyase
A4A60_12610	COG0252	asparaginase activity
A4A60_12615	COG1396	sequence-specific DNA binding
A4A60_12620	COG1379	DNA repair
A4A60_12625	COG0494	nUDIX hydrolase
A4A60_12635	COG0667	Aldo Keto reductase
A4A60_12645	COG1073	alpha beta
A4A60_12655	COG4918	Iron-sulphur cluster biosynthesis
A4A60_12660	COG0456	acetyltransferase
A4A60_12660	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
A4A60_12665	COG2329	Antibiotic biosynthesis monooxygenase
A4A60_12670	COG0456	acetyltransferase
A4A60_12680	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4A60_12690	COG2211	Major facilitator Superfamily
A4A60_12700	COG0346	lactoylglutathione lyase activity
A4A60_12705	COG1072	(Pantothenic acid kinase))
A4A60_12710	COG3048	D-serine ammonia-lyase activity
A4A60_12715	COG0300	oxidoreductase activity
A4A60_12720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4A60_12725	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A4A60_12735	COG4187	Peptidase family M20/M25/M40
A4A60_12740	COG1902	pentaerythritol trinitrate reductase activity
A4A60_12745	COG0596	Alpha beta hydrolase
A4A60_12755	COG1234	tRNA 3'-trailer cleavage
A4A60_12760	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A4A60_12765	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A4A60_12770	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4A60_12780	COG0706	membrane insertase activity
A4A60_12785	COG3361	conserved protein (COG2071)
A4A60_12790	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4A60_12795	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
A4A60_12800	COG0346	lactoylglutathione lyase activity
A4A60_12810	COG1376	ErfK ybiS ycfS ynhG family protein
A4A60_12815	COG4129	membrane
A4A60_12820	COG1126	abc transporter atp-binding protein
A4A60_12825	COG0765	amino acid transport
A4A60_12830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4A60_12840	COG1597	lipid kinase activity
A4A60_12845	COG2814	Major facilitator Superfamily
A4A60_12850	COG4978	Transcriptional regulator
A4A60_12850	COG0789	Transcriptional regulator
A4A60_12855	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4A60_12860	COG0022	dehydrogenase e1 component
A4A60_12865	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
A4A60_12870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4A60_12875	COG3426	butyrate kinase activity
A4A60_12880	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4A60_12885	COG0280	phosphate acetyltransferase
A4A60_12890	COG3290	protein histidine kinase activity
A4A60_12890	COG3829	transcription factor binding
A4A60_12900	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A4A60_12905	COG2079	MmgE PrpD family protein
A4A60_12910	COG0372	Belongs to the citrate synthase family
A4A60_12915	COG1960	acyl-CoA dehydrogenase activity
A4A60_12920	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4A60_12925	COG0183	Belongs to the thiolase family
A4A60_12930	COG0584	glycerophosphoryl diester phosphodiesterase
A4A60_12935	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4A60_12950	COG1902	pentaerythritol trinitrate reductase activity
A4A60_12960	COG0745	RESPONSE REGULATOR receiver
A4A60_12970	COG0750	zinc metalloprotease
A4A60_12975	COG0497	DNA recombination
A4A60_12980	COG1438	arginine binding
A4A60_12985	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A4A60_12990	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A4A60_12995	COG0142	geranyltranstransferase activity
A4A60_13000	COG1722	exodeoxyribonuclease VII activity
A4A60_13005	COG1570	exodeoxyribonuclease VII activity
A4A60_13010	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A4A60_13015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4A60_13020	COG1302	Protein conserved in bacteria
A4A60_13025	COG0439	Biotin carboxylase
A4A60_13030	COG0511	ligase activity, forming carbon-carbon bonds
A4A60_13070	COG3854	ATPases associated with a variety of cellular activities
A4A60_13080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A4A60_13085	COG0006	proline dipeptidase activity
A4A60_13090	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A4A60_13100	COG3872	metal-dependent enzyme
A4A60_13110	COG1752	Esterase of the alpha-beta hydrolase superfamily
A4A60_13115	COG1321	iron dependent repressor
A4A60_13120	COG0095	Lipoate-protein ligase
A4A60_13125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4A60_13130	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A4A60_13135	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
A4A60_13140	COG0404	The glycine cleavage system catalyzes the degradation of glycine
A4A60_13145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4A60_13160	COG1396	sequence-specific DNA binding
A4A60_13170	COG0681	Belongs to the peptidase S26 family
A4A60_13195	COG4940	Competence protein ComGF
A4A60_13205	COG4970	Tfp pilus assembly protein FimT
A4A60_13210	COG4537	Required for transformation and DNA binding
A4A60_13215	COG1459	type II secretion system
A4A60_13220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A4A60_13230	COG0517	IMP dehydrogenase activity
A4A60_13235	COG0598	Magnesium transport protein CorA
A4A60_13240	COG1253	flavin adenine dinucleotide binding
A4A60_13245	COG1366	Belongs to the anti-sigma-factor antagonist family
A4A60_13255	COG1393	Belongs to the ArsC family
A4A60_13270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4A60_13280	COG0011	TIGRFAM Protein of
A4A60_13290	COG2866	Carboxypeptidase
A4A60_13295	COG1368	sulfuric ester hydrolase activity
A4A60_13300	COG1940	carbohydrate kinase activity
A4A60_13305	COG4483	Protein conserved in bacteria
A4A60_13310	COG0705	Rhomboid family
A4A60_13310	COG0457	Tetratricopeptide repeat
A4A60_13320	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A4A60_13325	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A4A60_13330	COG0438	transferase activity, transferring glycosyl groups
A4A60_13345	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A4A60_13350	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4A60_13355	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4A60_13360	COG0581	inorganic phosphate transmembrane transporter activity
A4A60_13365	COG0573	inorganic phosphate transmembrane transporter activity
A4A60_13370	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A4A60_13380	COG0477	Major facilitator Superfamily
A4A60_13385	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A4A60_13390	COG2839	Protein conserved in bacteria
A4A60_13395	COG5521	maltodextrose utilization protein MalA
A4A60_13400	COG1388	LysM domain
A4A60_13405	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A4A60_13410	COG4709	membrane
A4A60_13415	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
A4A60_13420	COG0735	belongs to the Fur family
A4A60_13425	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4A60_13435	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A4A60_13440	COG0513	Belongs to the DEAD box helicase family
A4A60_13450	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A4A60_13455	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A4A60_13460	COG2384	SAM-dependent methyltransferase
A4A60_13465	COG2010	Cytochrome c
A4A60_13470	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4A60_13475	COG0358	DNA primase activity
A4A60_13480	COG1671	Belongs to the UPF0178 family
A4A60_13485	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A4A60_13490	COG0517	IMP dehydrogenase activity
A4A60_13495	COG0751	glycine-tRNA ligase activity
A4A60_13500	COG0752	glycyl-tRNA synthetase alpha subunit
A4A60_13505	COG1381	Involved in DNA repair and RecF pathway recombination
A4A60_13515	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A4A60_13520	COG0295	cytidine deaminase activity
A4A60_13525	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A4A60_13530	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A4A60_13535	COG1480	7TM receptor with intracellular HD hydrolase
A4A60_13545	COG1702	phosphate starvation-inducible protein PhoH
A4A60_13550	COG0561	phosphatase activity
A4A60_13565	COG4864	UPF0365 protein
A4A60_13570	COG1030	water channel activity
A4A60_13575	COG1610	YqeY-like protein
A4A60_13580	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A4A60_13585	COG1283	sodium-dependent phosphate transmembrane transporter activity
A4A60_13590	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4A60_13595	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A4A60_13600	COG2264	protein methyltransferase activity
A4A60_13605	COG0484	heat shock protein binding
A4A60_13610	COG0443	Heat shock 70 kDa protein
A4A60_13615	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A4A60_13620	COG1420	regulation of RNA biosynthetic process
A4A60_13625	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4A60_13630	COG0481	GTPase activity
A4A60_13640	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4A60_13645	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A4A60_13650	COG0268	Binds directly to 16S ribosomal RNA
A4A60_13655	COG1466	dna polymerase III delta subunit
A4A60_13665	COG0658	competence protein
A4A60_13665	COG2333	competence protein COMEC
A4A60_13670	COG2131	deaminase
A4A60_13675	COG1596	polysaccharide export
A4A60_13675	COG1555	photosystem II stabilization
A4A60_13680	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A4A60_13685	COG2226	methyltransferase
A4A60_13690	COG0799	negative regulation of ribosome biogenesis
A4A60_13695	COG1713	HD superfamily hydrolase involved in NAD metabolism
A4A60_13700	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A4A60_13705	COG1534	Rna-binding protein
A4A60_13710	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4A60_13715	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A4A60_13720	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
A4A60_13735	COG2755	lipolytic protein G-D-S-L family
A4A60_13740	COG5632	N-Acetylmuramoyl-L-alanine amidase
A4A60_13740	COG3409	Peptidoglycan-binding domain 1 protein
A4A60_13745	COG0398	Pfam SNARE associated Golgi protein
A4A60_13750	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
A4A60_13760	COG3209	COG3209 Rhs family protein
A4A60_13780	COG0114	fumarate hydratase activity
A4A60_13785	COG0583	DNA-binding transcription factor activity
A4A60_13795	COG0457	Tetratricopeptide repeat
A4A60_13900	COG0789	Transcriptional regulator
A4A60_13900	COG4978	Transcriptional regulator
A4A60_13905	COG2814	Major facilitator Superfamily
A4A60_13910	COG0456	acetyltransferase
A4A60_13915	COG3328	transposase activity
A4A60_13920	COG1253	flavin adenine dinucleotide binding
A4A60_13930	COG0697	spore germination
A4A60_13935	COG0583	DNA-binding transcription factor activity
A4A60_13940	COG2072	flavoprotein involved in K transport
A4A60_13945	COG1230	cation diffusion facilitator family transporter
A4A60_13960	COG1114	Component of the transport system for branched-chain amino acids
A4A60_13965	COG1687	branched-chain amino acid
A4A60_13970	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A4A60_13975	COG1522	sequence-specific DNA binding
A4A60_13980	COG2732	(Barnase) inhibitor
A4A60_13990	COG1335	isochorismatase
A4A60_14000	COG2318	DinB family
A4A60_14010	COG2070	2-Nitropropane dioxygenase
A4A60_14015	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A4A60_14030	COG3443	Belongs to the bacterial solute-binding protein 9 family
A4A60_14035	COG1595	DNA-templated transcription, initiation
A4A60_14040	COG0667	Aldo Keto reductase
A4A60_14045	COG3409	Peptidoglycan-binding domain 1 protein
A4A60_14050	COG5566	PFAM Mor transcription activator
A4A60_14055	COG0596	Alpha beta hydrolase
A4A60_14060	COG4991	sh3 domain protein
A4A60_14065	COG4991	sh3 domain protein
A4A60_14070	COG0346	lactoylglutathione lyase activity
A4A60_14080	COG5577	PFAM Coat F domain
A4A60_14085	COG1063	alcohol dehydrogenase
A4A60_14095	COG5577	PFAM Coat F domain
A4A60_14100	COG0789	Transcriptional regulator
A4A60_14110	COG1064	alcohol dehydrogenase
A4A60_14115	COG0693	protein deglycase activity
A4A60_14120	COG1621	beta-fructofuranosidase activity
A4A60_14125	COG3716	PTS system mannose fructose sorbose family IID component
A4A60_14130	COG3715	PTS system
A4A60_14135	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4A60_14140	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4A60_14145	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A4A60_14145	COG3933	PFAM sigma-54 factor interaction domain-containing protein
A4A60_14150	COG1113	amino acid transport
A4A60_14155	COG1280	lysine exporter protein (LysE YggA)
A4A60_14160	COG1378	Sugar-specific transcriptional regulator TrmB
A4A60_14165	COG1595	DNA-templated transcription, initiation
A4A60_14185	COG2124	cytochrome p450
A4A60_14185	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A4A60_14190	COG1309	transcriptional regulator
A4A60_14195	COG2226	methyltransferase
A4A60_14205	COG2116	formate transmembrane transporter activity
A4A60_14210	COG5609	conserved protein (DUF2294)
A4A60_14215	COG3383	formate dehydrogenase (NAD+) activity
A4A60_14220	COG2427	Protein of unknown function (DUF1641)
A4A60_14230	COG0626	cystathionine gamma-synthase activity
A4A60_14235	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4A60_14240	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A4A60_14245	COG2226	methyltransferase
A4A60_14260	COG0768	penicillin binding
A4A60_14265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4A60_14270	COG0572	uridine kinase
A4A60_14290	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A4A60_14295	COG3906	Belongs to the UPF0473 family
A4A60_14300	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A4A60_14305	COG4472	Bacterial protein of unknown function (DUF965)
A4A60_14310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A4A60_14315	COG0628	permease
A4A60_14320	COG1126	abc transporter atp-binding protein
A4A60_14325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4A60_14330	COG0765	amino acid transport
A4A60_14335	COG0765	amino acid transport
A4A60_14355	COG3881	PFAM PRC-barrel domain
A4A60_14360	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4A60_14365	COG0457	Tetratricopeptide repeat
A4A60_14370	COG0482	sulfurtransferase activity
A4A60_14375	COG1104	cysteine desulfurase activity
A4A60_14380	COG1959	2 iron, 2 sulfur cluster binding
A4A60_14385	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A4A60_14390	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A4A60_14400	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A4A60_14405	COG0124	histidyl-tRNA synthetase
A4A60_14415	COG3103	Sh3 type 3 domain protein
A4A60_14415	COG4991	sh3 domain protein
A4A60_14415	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4A60_14420	COG1490	D-aminoacyl-tRNA deacylase activity
A4A60_14425	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4A60_14430	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4A60_14435	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A4A60_14435	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A4A60_14440	COG5416	Lipopolysaccharide assembly protein A domain
A4A60_14445	COG0490	domain, Protein
A4A60_14450	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4A60_14450	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4A60_14460	COG2244	polysaccharide biosynthetic process
A4A60_14465	COG2323	membrane
A4A60_14475	COG1862	Preprotein translocase
A4A60_14480	COG0343	queuine tRNA-ribosyltransferase activity
A4A60_14485	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A4A60_14495	COG2255	four-way junction helicase activity
A4A60_14500	COG0632	four-way junction helicase activity
A4A60_14510	COG2814	Major facilitator Superfamily
A4A60_14515	COG0673	inositol 2-dehydrogenase activity
A4A60_14520	COG2112	serine threonine protein kinase
A4A60_14540	COG1115	amino acid carrier protein
A4A60_14545	COG0217	transcriptional regulatory protein
A4A60_14555	COG1388	LysM domain
A4A60_14560	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
A4A60_14565	COG0157	Belongs to the NadC ModD family
A4A60_14570	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
A4A60_14575	COG1104	cysteine desulfurase activity
A4A60_14580	COG1827	regulation of RNA biosynthetic process
A4A60_14585	COG0077	Prephenate dehydratase
A4A60_14590	COG4492	Belongs to the UPF0735 family
A4A60_14595	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A4A60_14600	COG3290	protein histidine kinase activity
A4A60_14610	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A4A60_14615	COG2868	ribosomal protein
A4A60_14620	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A4A60_14625	COG1994	Peptidase M50
A4A60_14630	COG0739	heme binding
A4A60_14635	COG2894	cell division
A4A60_14640	COG0850	regulation of cytokinetic process
A4A60_14645	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
A4A60_14650	COG1792	Involved in formation and maintenance of cell shape
A4A60_14655	COG1077	Cell shape determining protein MreB Mrl
A4A60_14660	COG2003	Belongs to the UPF0758 family
A4A60_14665	COG0424	maF-like protein
A4A60_14675	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A4A60_14680	COG0285	dihydrofolate synthase activity
A4A60_14685	COG0525	valine-tRNA ligase activity
A4A60_14695	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A4A60_14700	COG1388	LysM domain
A4A60_14705	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A4A60_14710	COG0113	porphobilinogen synthase activity
A4A60_14715	COG1587	Uroporphyrinogen-III synthase
A4A60_14720	COG0181	hydroxymethylbilane synthase activity
A4A60_14725	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4A60_14730	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A4A60_14740	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A4A60_14745	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A4A60_14750	COG1067	ATP-dependent peptidase activity
A4A60_14750	COG0470	DNA polymerase III
A4A60_14755	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A4A60_14760	COG0544	peptidyl-prolyl cis-trans isomerase activity
A4A60_14765	COG0457	Tetratricopeptide repeat
A4A60_14765	COG1477	protein flavinylation
A4A60_14770	COG0066	3-isopropylmalate dehydratase activity
A4A60_14775	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A4A60_14780	COG0473	3-isopropylmalate dehydrogenase activity
A4A60_14785	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A4A60_14790	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A4A60_14795	COG0440	acetolactate synthase activity
A4A60_14800	COG0028	Belongs to the TPP enzyme family
A4A60_14820	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
A4A60_14830	COG2801	Transposase and inactivated derivatives
A4A60_14855	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
A4A60_14880	COG0622	Phosphoesterase
A4A60_14885	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A4A60_14890	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A4A60_14895	COG5401	PFAM Sporulation and spore germination
A4A60_14900	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A4A60_14905	COG1846	Transcriptional regulator
A4A60_14910	COG2197	response regulator
A4A60_14915	COG0824	Thioesterase
A4A60_14920	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4A60_14925	COG1053	succinate dehydrogenase
A4A60_14930	COG2009	succinate dehydrogenase
A4A60_14940	COG1719	4-vinyl reductase, 4VR
A4A60_14945	COG0527	aspartate kinase activity
A4A60_14950	COG0322	excinuclease ABC activity
A4A60_14955	COG3118	belongs to the thioredoxin family
A4A60_14960	COG3534	alpha-L-arabinofuranosidase
A4A60_14965	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
A4A60_14970	COG2086	electron transfer activity
A4A60_14975	COG1024	Enoyl-CoA hydratase
A4A60_14980	COG1309	transcriptional regulator
A4A60_14985	COG0318	PFAM AMP-dependent synthetase and ligase
A4A60_14990	COG3766	membrane
A4A60_14995	COG1193	negative regulation of DNA recombination
A4A60_15000	COG1796	DNA polymerase
A4A60_15000	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A4A60_15005	COG1286	toxin biosynthetic process
A4A60_15010	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
A4A60_15015	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A4A60_15020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4A60_15020	COG0072	phenylalanine-tRNA ligase activity
A4A60_15025	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A4A60_15035	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4A60_15045	COG3835	regulator
A4A60_15050	COG0277	FAD linked oxidase domain protein
A4A60_15055	COG0247	lactate metabolic process
A4A60_15060	COG0346	lactoylglutathione lyase activity
A4A60_15065	COG1966	Carbon starvation protein
A4A60_15070	COG3534	alpha-L-arabinofuranosidase
A4A60_15075	COG0395	ABC-type sugar transport system, permease component
A4A60_15080	COG1175	transmembrane transport
A4A60_15085	COG1653	transport
A4A60_15090	COG0371	Dehydrogenase
A4A60_15100	COG0235	Class ii aldolase
A4A60_15105	COG1069	ribulokinase activity
A4A60_15110	COG2160	L-arabinose isomerase activity
A4A60_15115	COG3507	Belongs to the glycosyl hydrolase 43 family
A4A60_15120	COG1363	Peptidase, m42
A4A60_15130	COG3326	Membrane
A4A60_15135	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A4A60_15140	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A4A60_15145	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A4A60_15155	COG1346	cytolysis
A4A60_15160	COG1380	Effector of murein hydrolase LrgA
A4A60_15165	COG3279	Response regulator of the LytR AlgR family
A4A60_15170	COG3275	phosphorelay sensor kinase activity
A4A60_15180	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A4A60_15190	COG0398	Pfam SNARE associated Golgi protein
A4A60_15195	COG1484	DNA-dependent DNA replication
A4A60_15200	COG3611	Membrane attachment protein
A4A60_15205	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A4A60_15210	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
A4A60_15215	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A4A60_15220	COG1733	regulation of RNA biosynthetic process
A4A60_15225	COG2814	Major facilitator Superfamily
A4A60_15230	COG0656	L-ascorbic acid biosynthetic process
A4A60_15235	COG0237	dephospho-CoA kinase activity
A4A60_15250	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A4A60_15255	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4A60_15255	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4A60_15260	COG5002	protein histidine kinase activity
A4A60_15265	COG0745	RESPONSE REGULATOR receiver
A4A60_15270	COG0039	L-malate dehydrogenase activity
A4A60_15275	COG0538	isocitrate dehydrogenase activity
A4A60_15280	COG0372	Belongs to the citrate synthase family
A4A60_15290	COG2707	UPF0756 membrane protein
A4A60_15295	COG0628	permease
A4A60_15300	COG3030	protein affecting phage T7 exclusion by the F plasmid
A4A60_15305	COG0469	pyruvate kinase activity
A4A60_15310	COG0205	6-phosphofructokinase activity
A4A60_15315	COG0825	malonyl-CoA metabolic process
A4A60_15320	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A4A60_15325	COG0281	malic enzyme
A4A60_15330	COG0587	DNA-directed DNA polymerase activity
A4A60_15350	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A4A60_15360	COG4109	DRTGG domain
A4A60_15365	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A4A60_15370	COG1028	Short-chain dehydrogenase reductase Sdr
A4A60_15380	COG0165	Argininosuccinate lyase
A4A60_15385	COG0137	argininosuccinate synthase activity
A4A60_15390	COG0521	Mo-molybdopterin cofactor biosynthetic process
A4A60_15395	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A4A60_15405	COG0827	DNA restriction-modification system
A4A60_15410	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A4A60_15415	COG3874	Sporulation protein YtfJ
A4A60_15425	COG1714	RDD family
A4A60_15430	COG0616	signal peptide processing
A4A60_15435	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A4A60_15445	COG1574	metal-dependent hydrolase with the TIM-barrel fold
A4A60_15450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4A60_15460	COG0301	tRNA thio-modification
A4A60_15465	COG1104	cysteine desulfurase activity
A4A60_15470	COG1114	Component of the transport system for branched-chain amino acids
A4A60_15475	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
A4A60_15480	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
A4A60_15485	COG1309	transcriptional regulator
A4A60_15490	COG1956	GAF domain-containing protein
A4A60_15495	COG2199	diguanylate cyclase activity
A4A60_15495	COG2203	Gaf domain
A4A60_15500	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A4A60_15510	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A4A60_15515	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A4A60_15520	COG0454	-acetyltransferase
A4A60_15525	COG0517	IMP dehydrogenase activity
A4A60_15530	COG0123	including yeast histone deacetylase and acetoin utilization protein
A4A60_15535	COG1360	Flagellar Motor Protein
A4A60_15540	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A4A60_15545	COG1609	Transcriptional regulator
A4A60_15550	COG1605	Chorismate mutase
A4A60_15550	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A4A60_15555	COG3118	belongs to the thioredoxin family
A4A60_15560	COG4980	gas vesicle protein
A4A60_15565	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
A4A60_15570	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A4A60_15575	COG1674	ftsk spoiiie
A4A60_15580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4A60_15585	COG4848	Belongs to the UPF0354 family
A4A60_15590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4A60_15600	COG1363	Peptidase, m42
A4A60_15605	COG5584	Small secreted protein
A4A60_15610	COG0281	malic enzyme
A4A60_15615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4A60_15620	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A4A60_15630	COG0510	thiamine kinase activity
A4A60_15635	COG1523	belongs to the glycosyl hydrolase 13 family
A4A60_15640	COG1597	lipid kinase activity
A4A60_15650	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
A4A60_15655	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4A60_15660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4A60_15665	COG2252	PERMEase
A4A60_15670	COG4473	ABC transporter
A4A60_15675	COG1131	(ABC) transporter
A4A60_15680	COG1349	DNA-binding transcription factor activity
A4A60_15685	COG1187	pseudouridine synthase activity
A4A60_15690	COG2244	polysaccharide biosynthetic process
A4A60_15695	COG2081	HI0933 family
A4A60_15700	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
A4A60_15720	COG1653	transport
A4A60_15725	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
A4A60_15730	COG4209	transmembrane transport
A4A60_15740	COG1653	transport
A4A60_15745	COG0395	ABC-type sugar transport system, permease component
A4A60_15750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4A60_15755	COG2124	cytochrome p450
A4A60_15760	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A4A60_15770	COG0156	8-amino-7-oxononanoate synthase activity
A4A60_15775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A4A60_15780	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
A4A60_15785	COG1073	alpha beta
A4A60_15810	COG1486	melibiose metabolic process
A4A60_15815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4A60_15820	COG0495	leucyl-tRNA aminoacylation
A4A60_15830	COG2202	Pas domain
A4A60_15830	COG1366	Belongs to the anti-sigma-factor antagonist family
A4A60_15835	COG2814	Major facilitator Superfamily
A4A60_15850	COG0577	efflux transmembrane transporter activity
A4A60_15855	COG1136	(ABC) transporter
A4A60_15860	COG2205	protein histidine kinase activity
A4A60_15865	COG0745	RESPONSE REGULATOR receiver
A4A60_15870	COG0577	efflux transmembrane transporter activity
A4A60_15875	COG1136	(ABC) transporter
A4A60_15890	COG1131	(ABC) transporter
A4A60_15895	COG1725	Transcriptional regulator
A4A60_15910	COG1242	4 iron, 4 sulfur cluster binding
A4A60_15915	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A4A60_15925	COG2267	carboxylic ester hydrolase activity
A4A60_15930	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A4A60_15935	COG1113	amino acid transport
A4A60_15940	COG0367	asparagine synthase
A4A60_15945	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A4A60_15950	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A4A60_15960	COG1506	peptidase
A4A60_15965	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
A4A60_15970	COG1116	anion transmembrane transporter activity
A4A60_15975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4A60_15980	COG0494	nUDIX hydrolase
A4A60_15985	COG4824	toxin secretion phage lysis holin
A4A60_15990	COG0783	Belongs to the Dps family
A4A60_16005	COG1854	S-ribosylhomocysteine lyase activity
A4A60_16010	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A4A60_16015	COG0288	reversible hydration of carbon dioxide
A4A60_16020	COG0254	rRNA binding
A4A60_16025	COG1271	oxidase subunit
A4A60_16030	COG1294	oxidase, subunit
A4A60_16040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4A60_16045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A4A60_16045	COG1321	iron dependent repressor
A4A60_16050	COG1121	(ABC) transporter
A4A60_16055	COG0803	Belongs to the bacterial solute-binding protein 9 family
A4A60_16060	COG4948	Mandelate Racemase Muconate Lactonizing
A4A60_16065	COG0318	PFAM AMP-dependent synthetase and ligase
A4A60_16070	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A4A60_16075	COG0596	Alpha beta hydrolase
A4A60_16080	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A4A60_16085	COG1169	isochorismate synthase
A4A60_16090	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A4A60_16095	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A4A60_16100	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A4A60_16105	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4A60_16110	COG0438	transferase activity, transferring glycosyl groups
A4A60_16120	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A4A60_16125	COG0438	transferase activity, transferring glycosyl groups
A4A60_16130	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A4A60_16135	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A4A60_16140	COG0058	SHG alpha-glucan phosphorylase activity
A4A60_16145	COG0297	glycogen (starch) synthase activity
A4A60_16150	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A4A60_16155	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
A4A60_16160	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
A4A60_16290	COG3859	Proton-coupled thiamine transporter YuaJ
A4A60_16295	COG1247	-acetyltransferase
A4A60_16300	COG2268	Band 7 protein
A4A60_16305	COG1585	Membrane protein implicated in regulation of membrane protease activity
A4A60_16310	COG2318	DinB family
A4A60_16325	COG1454	alcohol dehydrogenase
A4A60_16335	COG1510	regulation of RNA biosynthetic process
A4A60_16345	COG0569	domain protein
A4A60_16350	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4A60_16355	COG4682	membrane
A4A60_16360	COG1705	Flagellar rod assembly protein muramidase FlgJ
A4A60_16365	COG0477	Major facilitator Superfamily
A4A60_16370	COG5553	Cysteine dioxygenase type I
A4A60_16380	COG1968	undecaprenyl-diphosphatase activity
A4A60_16385	COG0628	permease
A4A60_16390	COG0673	inositol 2-dehydrogenase activity
A4A60_16395	COG4806	L-rhamnose isomerase
A4A60_16400	COG3254	rhamnose metabolic process
A4A60_16405	COG1070	Carbohydrate kinase
A4A60_16410	COG1349	DNA-binding transcription factor activity
A4A60_16415	COG3347	Dehydrogenase
A4A60_16415	COG1028	Short-chain dehydrogenase reductase Sdr
A4A60_16430	COG0840	transmembrane signaling receptor activity
A4A60_16435	COG0840	transmembrane signaling receptor activity
A4A60_16440	COG0840	transmembrane signaling receptor activity
A4A60_16460	COG0366	Alpha amylase catalytic
A4A60_16465	COG1253	flavin adenine dinucleotide binding
A4A60_16470	COG2738	Putative neutral zinc metallopeptidase
A4A60_16485	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4A60_16500	COG0166	Belongs to the GPI family
A4A60_16505	COG1979	alcohol dehydrogenase
A4A60_16510	COG1979	alcohol dehydrogenase
A4A60_16515	COG2155	Conserved Protein
A4A60_16520	COG1098	S1 RNA binding domain
A4A60_16525	COG0436	Aminotransferase
A4A60_16530	COG1522	sequence-specific DNA binding
A4A60_16535	COG2267	carboxylic ester hydrolase activity
A4A60_16545	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A4A60_16550	COG2205	protein histidine kinase activity
A4A60_16560	COG5018	Exonuclease
A4A60_16570	COG2814	Major facilitator Superfamily
A4A60_16575	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4A60_16580	COG3011	Protein conserved in bacteria
A4A60_16590	COG3290	protein histidine kinase activity
A4A60_16595	COG4565	transcriptional regulatory protein
A4A60_16620	COG3493	citrate carrier protein
A4A60_16630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A4A60_16630	COG2111	Na H antiporter
A4A60_16635	COG2111	Na H antiporter
A4A60_16640	COG1006	Multisubunit Na H antiporter MnhC subunit
A4A60_16645	COG0651	ATP synthesis coupled electron transport
A4A60_16650	COG1863	multisubunit Na H antiporter MnhE subunit
A4A60_16655	COG2212	antiporter activity
A4A60_16660	COG1320	monovalent cation:proton antiporter activity
A4A60_16665	COG2050	protein possibly involved in aromatic compounds catabolism
A4A60_16670	COG2197	response regulator
A4A60_16675	COG4585	Histidine kinase
A4A60_16685	COG0142	geranyltranstransferase activity
A4A60_16700	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
A4A60_16705	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A4A60_16710	COG1335	isochorismatase
A4A60_16715	COG5506	Protein of unknown function (DUF1694)
A4A60_16730	COG0628	permease
A4A60_16745	COG1418	mRNA catabolic process
A4A60_16750	COG1028	Short-chain dehydrogenase reductase Sdr
A4A60_16760	COG1511	domain protein
A4A60_16765	COG0433	COG0433 Predicted ATPase
A4A60_16765	COG1674	ftsk spoiiie
A4A60_16770	COG4499	WXG100 protein secretion system (Wss), protein YukC
A4A60_16775	COG5417	Belongs to the EsaB family
A4A60_16780	COG4842	Belongs to the WXG100 family
A4A60_16785	COG2508	Transcriptional regulator
A4A60_16785	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A4A60_16790	COG0686	Belongs to the AlaDH PNT family
A4A60_16795	COG5634	Uncharacterized conserved protein (DUF2278)
A4A60_16800	COG3251	PFAM MbtH domain protein
A4A60_16805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4A60_16810	COG3433	isochorismatase activity
A4A60_16810	COG1535	isochorismatase
A4A60_16815	COG1021	2,3-dihydroxybenzoate-AMP ligase
A4A60_16820	COG1169	isochorismate synthase
A4A60_16825	COG1028	Short-chain dehydrogenase reductase Sdr
A4A60_16830	COG2819	hydrolase of the alpha beta superfamily
A4A60_16835	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A4A60_16840	COG1268	BioY protein
A4A60_16845	COG2056	Na+-H+ antiporter family
A4A60_16850	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A4A60_16855	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
A4A60_16860	COG3584	3D domain protein
A4A60_16875	COG1252	NADH dehydrogenase
A4A60_16880	COG0492	ferredoxin-NADP+ reductase activity
A4A60_16890	COG0516	GMP reductase activity
A4A60_16905	COG0316	Belongs to the HesB IscA family
A4A60_16910	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A4A60_16915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A4A60_16925	COG4844	belongs to the
A4A60_16930	COG1252	NADH dehydrogenase
A4A60_16935	COG4837	Protein of unknown function (DUF1462)
A4A60_16940	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
A4A60_16945	COG4946	Tricorn protease homolog
A4A60_16945	COG1506	peptidase
A4A60_16945	COG0823	Involved in the tonB-independent uptake of proteins
A4A60_16950	COG0083	homoserine kinase activity
A4A60_16955	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A4A60_16960	COG0460	homoserine dehydrogenase
A4A60_16965	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A4A60_16970	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A4A60_16975	COG0647	UMP catabolic process
A4A60_16980	COG2445	Protein of unknown function DUF86
A4A60_16985	COG4470	Protein conserved in bacteria
A4A60_16995	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
A4A60_17000	COG0739	heme binding
A4A60_17010	COG3377	Domain of unknown function (DUF1805)
A4A60_17015	COG0737	Belongs to the 5'-nucleotidase family
A4A60_17020	COG0730	response to heat
A4A60_17025	COG1801	Protein of unknown function DUF72
A4A60_17035	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4A60_17040	COG2508	Transcriptional regulator
A4A60_17045	COG2233	PERMEase
A4A60_17055	COG3648	Uricase
A4A60_17055	COG3195	allantoin biosynthetic process
A4A60_17060	COG2351	hydroxyisourate hydrolase activity
A4A60_17075	COG2080	2 iron, 2 sulfur cluster binding
A4A60_17080	COG1529	Aldehyde oxidase and xanthine dehydrogenase
A4A60_17085	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
A4A60_17090	COG2068	MobA-Related Protein
A4A60_17095	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
A4A60_17100	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
A4A60_17105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4A60_17115	COG2356	endonuclease I
A4A60_17120	COG3842	ATPase activity
A4A60_17125	COG2188	Transcriptional regulator
A4A60_17130	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4A60_17140	COG1175	transmembrane transport
A4A60_17145	COG1653	transport
A4A60_17150	COG2222	sugar isomerase
A4A60_17155	COG0322	excinuclease ABC activity
A4A60_17160	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4A60_17175	COG2801	Transposase and inactivated derivatives
A4A60_17185	COG0346	lactoylglutathione lyase activity
A4A60_17190	COG0640	Transcriptional regulator
A4A60_17200	COG5444	nuclease activity
A4A60_17210	COG3409	Peptidoglycan-binding domain 1 protein
A4A60_17210	COG5632	N-Acetylmuramoyl-L-alanine amidase
A4A60_17215	COG4824	toxin secretion phage lysis holin
A4A60_17245	COG5412	phage tail tape measure protein
A4A60_17245	COG3953	SLT domain
A4A60_17340	COG0582	viral genome integration into host DNA
A4A60_17445	COG0719	Fe-S assembly protein
A4A60_17450	COG0822	iron-sulfur transferase activity
A4A60_17455	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A4A60_17460	COG0719	Fe-S assembly protein
A4A60_17465	COG0396	ATPase activity
A4A60_17475	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
A4A60_17480	COG1464	Belongs to the NlpA lipoprotein family
A4A60_17485	COG2011	ABC-type metal ion transport system permease component
A4A60_17490	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A4A60_17500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4A60_17505	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A4A60_17515	COG0509	glycine decarboxylation via glycine cleavage system
A4A60_17520	COG1393	Belongs to the ArsC family
A4A60_17525	COG1960	acyl-CoA dehydrogenase activity
A4A60_17530	COG0183	Belongs to the thiolase family
A4A60_17535	COG1024	Enoyl-CoA hydratase
A4A60_17535	COG1250	3-hydroxyacyl-CoA dehydrogenase
A4A60_17545	COG0506	proline dehydrogenase activity
A4A60_17555	COG5577	PFAM Coat F domain
A4A60_17560	COG1846	Transcriptional regulator
A4A60_17565	COG0477	Major facilitator Superfamily
A4A60_17570	COG1942	4-Oxalocrotonate Tautomerase
A4A60_17575	COG1028	Short-chain dehydrogenase reductase Sdr
A4A60_17580	COG0583	DNA-binding transcription factor activity
A4A60_17590	COG1120	ATPase activity
A4A60_17610	COG1131	(ABC) transporter
A4A60_17660	COG0783	Belongs to the Dps family
A4A60_17670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4A60_17675	COG0745	RESPONSE REGULATOR receiver
A4A60_17680	COG2205	protein histidine kinase activity
A4A60_17680	COG2770	Histidine kinase
A4A60_17690	COG1309	transcriptional regulator
A4A60_17695	COG0114	fumarate hydratase activity
A4A60_17705	COG0697	spore germination
A4A60_17710	COG0814	amino acid
A4A60_17720	COG2197	response regulator
A4A60_17725	COG4585	Histidine kinase
A4A60_17730	COG4758	membrane
A4A60_17735	COG3595	metallopeptidase activity
A4A60_17740	COG1842	Phage shock protein A
A4A60_17745	COG4758	membrane
A4A60_17750	COG2814	Major facilitator Superfamily
A4A60_17755	COG2096	Adenosyltransferase
A4A60_17760	COG1120	ATPase activity
A4A60_17765	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4A60_17770	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4A60_17775	COG1028	Short-chain dehydrogenase reductase Sdr
A4A60_17780	COG3386	PFAM SMP-30 Gluconolaconase
A4A60_17785	COG2205	protein histidine kinase activity
A4A60_17790	COG0745	RESPONSE REGULATOR receiver
A4A60_17800	COG1191	sigma factor activity
A4A60_17810	COG2140	Oxalate decarboxylase
A4A60_17820	COG0577	efflux transmembrane transporter activity
A4A60_17825	COG1136	(ABC) transporter
A4A60_17830	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4A60_17835	COG1120	ATPase activity
A4A60_17840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4A60_17845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4A60_17850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4A60_17860	COG0531	amino acid
A4A60_17870	COG1988	membrane-bound metal-dependent
A4A60_17875	COG1368	sulfuric ester hydrolase activity
A4A60_17880	COG1910	domain protein
A4A60_17885	COG0725	ABC transporter, periplasmic molybdate-binding protein
A4A60_17890	COG4149	molybdate abc transporter
A4A60_17895	COG0656	L-ascorbic acid biosynthetic process
A4A60_17905	COG0025	NhaP-type Na H and K H
A4A60_17910	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
A4A60_17915	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
A4A60_17920	COG3973	AAA domain
A4A60_17930	COG2860	membrane
A4A60_17935	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A4A60_17940	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4A60_17945	COG2217	Heavy metal translocating P-type atpase
A4A60_17955	COG2217	Heavy metal translocating P-type atpase
A4A60_17960	COG2608	mercury ion transmembrane transporter activity
A4A60_17965	COG1937	Protein conserved in bacteria
A4A60_17970	COG0673	inositol 2-dehydrogenase activity
A4A60_17980	COG1289	transmembrane transporter activity
A4A60_17990	COG2076	Multidrug Resistance protein
A4A60_17995	COG1309	transcriptional regulator
A4A60_18000	COG1028	Short-chain dehydrogenase reductase Sdr
A4A60_18010	COG5444	nuclease activity
A4A60_18025	COG3409	Peptidoglycan-binding domain 1 protein
A4A60_18025	COG5632	N-Acetylmuramoyl-L-alanine amidase
A4A60_18030	COG4824	toxin secretion phage lysis holin
A4A60_18050	COG3942	CHAP domain
A4A60_18050	COG1705	Flagellar rod assembly protein muramidase FlgJ
A4A60_18160	COG0582	viral genome integration into host DNA
A4A60_18270	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A4A60_18275	COG0557	exoribonuclease II activity
A4A60_18280	COG1647	Serine aminopeptidase, S33
A4A60_18285	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4A60_18290	COG0596	Alpha beta hydrolase
A4A60_18295	COG1476	TRANSCRIPTIONal
A4A60_18300	COG1396	sequence-specific DNA binding
A4A60_18305	COG1396	sequence-specific DNA binding
A4A60_18310	COG1733	regulation of RNA biosynthetic process
A4A60_18315	COG0840	transmembrane signaling receptor activity
A4A60_18320	COG1174	glycine betaine transport
A4A60_18325	COG1732	Glycine betaine
A4A60_18330	COG1174	glycine betaine transport
A4A60_18335	COG0517	IMP dehydrogenase activity
A4A60_18335	COG1125	glycine betaine transport
A4A60_18340	COG1510	regulation of RNA biosynthetic process
A4A60_18345	COG1174	glycine betaine transport
A4A60_18350	COG1732	Glycine betaine
A4A60_18355	COG1174	glycine betaine transport
A4A60_18360	COG0517	IMP dehydrogenase activity
A4A60_18360	COG1125	glycine betaine transport
A4A60_18365	COG1510	regulation of RNA biosynthetic process
A4A60_18370	COG2095	MarC family integral membrane protein
A4A60_18380	COG3064	Membrane
A4A60_18385	COG4640	response to antibiotic
A4A60_18390	COG0456	acetyltransferase
A4A60_18395	COG0148	phosphopyruvate hydratase activity
A4A60_18400	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A4A60_18405	COG0149	triose-phosphate isomerase activity
A4A60_18410	COG0126	phosphoglycerate kinase activity
A4A60_18420	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A4A60_18425	COG2390	Transcriptional regulator
A4A60_18430	COG2814	Major facilitator Superfamily
A4A60_18435	COG1609	Transcriptional regulator
A4A60_18440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4A60_18445	COG0583	DNA-binding transcription factor activity
A4A60_18450	COG0697	spore germination
A4A60_18455	COG1113	amino acid transport
A4A60_18465	COG1556	Lactate utilization protein
A4A60_18470	COG1139	Iron-sulfur cluster binding protein
A4A60_18475	COG0247	lactate metabolic process
A4A60_18490	COG2197	response regulator
A4A60_18495	COG4585	Histidine kinase
A4A60_18500	COG0842	Transport permease protein
A4A60_18505	COG1131	(ABC) transporter
A4A60_18510	COG0596	Alpha beta hydrolase
A4A60_18515	COG2208	phosphoserine phosphatase activity
A4A60_18520	COG3867	Arabinogalactan endo-beta-1,4-galactanase
A4A60_18525	COG1874	Beta-galactosidase
A4A60_18530	COG3833	ABC-type maltose transport systems, permease component
A4A60_18535	COG1175	transmembrane transport
A4A60_18540	COG2182	Extracellular solute-binding protein
A4A60_18545	COG1609	Transcriptional regulator
A4A60_18550	COG2186	Transcriptional regulator
A4A60_18555	COG1620	l-lactate permease
A4A60_18570	COG5039	Polysaccharide pyruvyl transferase
A4A60_18575	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4A60_18580	COG0110	maltose O-acetyltransferase activity
A4A60_18585	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A4A60_18590	COG2244	polysaccharide biosynthetic process
A4A60_18595	COG1216	Glycosyl transferase, family 2
A4A60_18600	COG5039	Polysaccharide pyruvyl transferase
A4A60_18605	COG1216	Glycosyl transferase, family 2
A4A60_18615	COG0438	transferase activity, transferring glycosyl groups
A4A60_18620	COG1215	transferase activity, transferring glycosyl groups
A4A60_18625	COG0438	transferase activity, transferring glycosyl groups
A4A60_18630	COG1086	Polysaccharide biosynthesis protein
A4A60_18635	COG0489	protein tyrosine kinase activity
A4A60_18640	COG3944	biosynthesis protein
A4A60_18645	COG1396	sequence-specific DNA binding
A4A60_18650	COG2272	Belongs to the type-B carboxylesterase lipase family
A4A60_18660	COG3479	Phenolic acid decarboxylase
A4A60_18670	COG1794	racemase activity, acting on amino acids and derivatives
A4A60_18680	COG1621	beta-fructofuranosidase activity
A4A60_18685	COG1621	beta-fructofuranosidase activity
A4A60_18690	COG0531	amino acid
A4A60_18695	COG1309	transcriptional regulator
A4A60_18700	COG2076	Multidrug Resistance protein
A4A60_18705	COG2076	Multidrug Resistance protein
A4A60_18720	COG0740	serine-type endopeptidase activity
A4A60_18725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A4A60_18730	COG0366	Alpha amylase catalytic
A4A60_18735	COG1554	hydrolase, family 65, central catalytic
A4A60_18740	COG5521	maltodextrose utilization protein MalA
A4A60_18745	COG3833	ABC-type maltose transport systems, permease component
A4A60_18750	COG1175	transmembrane transport
A4A60_18755	COG2182	Extracellular solute-binding protein
A4A60_18760	COG0366	Alpha amylase catalytic
A4A60_18765	COG1609	Transcriptional regulator
A4A60_18770	COG1611	Belongs to the LOG family
A4A60_18775	COG1694	Mazg nucleotide pyrophosphohydrolase
A4A60_18780	COG0659	secondary active sulfate transmembrane transporter activity
A4A60_18785	COG0288	reversible hydration of carbon dioxide
A4A60_18790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4A60_18795	COG0577	efflux transmembrane transporter activity
A4A60_18800	COG1136	(ABC) transporter
A4A60_18805	COG5002	protein histidine kinase activity
A4A60_18810	COG0745	RESPONSE REGULATOR receiver
A4A60_18820	COG2162	N-hydroxyarylamine O-acetyltransferase activity
A4A60_18825	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4A60_18830	COG1481	regulation of sporulation
A4A60_18835	COG0391	Required for morphogenesis under gluconeogenic growth conditions
A4A60_18840	COG1660	Displays ATPase and GTPase activities
A4A60_18845	COG1051	belongs to the nudix hydrolase family
A4A60_18850	COG0492	ferredoxin-NADP+ reductase activity
A4A60_18855	COG0791	NLP P60 protein
A4A60_18855	COG3883	PFAM NLP P60 protein
A4A60_18860	COG0457	Tetratricopeptide repeat
A4A60_18865	COG1132	(ABC) transporter
A4A60_18885	COG0140	phosphoribosyl-ATP diphosphatase activity
A4A60_18885	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A4A60_18890	COG0107	imidazoleglycerol-phosphate synthase activity
A4A60_18895	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A4A60_18900	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A4A60_18905	COG0131	Imidazoleglycerol-phosphate dehydratase
A4A60_18910	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A4A60_18915	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A4A60_18920	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A4A60_18925	COG4990	cell redox homeostasis
A4A60_18930	COG5297	Belongs to the glycosyl hydrolase family 6
A4A60_18940	COG2801	Transposase and inactivated derivatives
A4A60_18945	COG0110	maltose O-acetyltransferase activity
A4A60_18950	COG0546	phosphoglycolate phosphatase activity
A4A60_18955	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A4A60_18960	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A4A60_18965	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A4A60_18970	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A4A60_18975	COG0363	glucosamine-6-phosphate deaminase activity
A4A60_18985	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
A4A60_19000	COG1950	PFAM Membrane protein of
A4A60_19005	COG1983	PspC domain protein
A4A60_19010	COG3595	metallopeptidase activity
A4A60_19025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A4A60_19030	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4A60_19035	COG0556	nucleotide-excision repair
A4A60_19040	COG4897	Protein conserved in bacteria
A4A60_19045	COG3848	Pyruvate phosphate dikinase
A4A60_19045	COG0574	Belongs to the PEP-utilizing enzyme family
A4A60_19050	COG1309	transcriptional regulator
A4A60_19055	COG2814	Major facilitator Superfamily
A4A60_19060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4A60_19070	COG0793	Belongs to the peptidase S41A family
A4A60_19070	COG3409	Peptidoglycan-binding domain 1 protein
A4A60_19075	COG2177	Part of the ABC transporter FtsEX involved in
A4A60_19080	COG2884	Cell division ATP-binding protein ftsE
A4A60_19085	COG2010	Cytochrome c
A4A60_19090	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4A60_19095	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A4A60_19100	COG0653	protein targeting
A4A60_19110	COG2801	Transposase and inactivated derivatives
A4A60_19115	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
A4A60_19130	COG1516	flagellar protein fliS
A4A60_19135	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A4A60_19140	COG1334	flagellar protein FlaG
A4A60_19145	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A4A60_19150	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
A4A60_19155	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
A4A60_19165	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A4A60_19170	COG1256	bacterial-type flagellum assembly
A4A60_19170	COG4786	Flagellar basal body rod
A4A60_19175	COG3418	PFAM FlgN family protein
A4A60_19180	COG2747	anti-sigma28 factor FlgM
A4A60_19190	COG1040	competence protein
A4A60_19200	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A4A60_19205	COG1307	EDD domain protein, DegV family
A4A60_19210	COG2197	response regulator
A4A60_19215	COG4585	Histidine kinase
A4A60_19220	COG1739	Uncharacterized protein family UPF0029
A4A60_19225	COG1316	TRANSCRIPTIONal
A4A60_19260	COG1131	(ABC) transporter
A4A60_19270	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4A60_19275	COG0438	transferase activity, transferring glycosyl groups
A4A60_19280	COG1215	transferase activity, transferring glycosyl groups
A4A60_19285	COG3206	protein involved in exopolysaccharide biosynthesis
A4A60_19290	COG3307	-O-antigen
A4A60_19295	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A4A60_19300	COG0297	glycogen (starch) synthase activity
A4A60_19300	COG0438	transferase activity, transferring glycosyl groups
A4A60_19305	COG2244	polysaccharide biosynthetic process
A4A60_19320	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A4A60_19325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A4A60_19335	COG1134	teichoic acid transport
A4A60_19340	COG1682	transport, permease protein
A4A60_19355	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A4A60_19355	COG0463	Glycosyl transferase, family 2
A4A60_19360	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A4A60_19365	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A4A60_19370	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A4A60_19375	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A4A60_19380	COG4193	domain, Protein
A4A60_19385	COG1482	cell wall glycoprotein biosynthetic process
A4A60_19415	COG1316	TRANSCRIPTIONal
A4A60_19420	COG0561	phosphatase activity
A4A60_19425	COG0791	NLP P60 protein
A4A60_19440	COG2843	Capsule synthesis protein
A4A60_19450	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A4A60_19460	COG1609	Transcriptional regulator
A4A60_19465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4A60_19470	COG1869	D-ribose catabolic process
A4A60_19475	COG1129	ABC transporter
A4A60_19480	COG1172	Belongs to the binding-protein-dependent transport system permease family
A4A60_19485	COG1879	ABC-type sugar transport system periplasmic component
A4A60_19490	COG3103	Sh3 type 3 domain protein
A4A60_19500	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4A60_19505	COG3527	Alpha-acetolactate decarboxylase
A4A60_19510	COG0028	Belongs to the TPP enzyme family
A4A60_19515	COG0583	DNA-binding transcription factor activity
A4A60_19535	COG5337	Spore coat protein CotH
A4A60_19545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A4A60_19555	COG0405	Gamma-glutamyltransferase
A4A60_19560	COG1522	sequence-specific DNA binding
A4A60_19565	COG2059	Chromate
A4A60_19570	COG2059	Chromate
A4A60_19580	COG0655	NAD(P)H dehydrogenase (quinone) activity
A4A60_19585	COG0583	DNA-binding transcription factor activity
A4A60_19615	COG5444	nuclease activity
A4A60_19630	COG3878	Protein conserved in bacteria
A4A60_19635	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
A4A60_19640	COG4464	protein tyrosine phosphatase activity
A4A60_19645	COG0489	protein tyrosine kinase activity
A4A60_19650	COG3944	biosynthesis protein
A4A60_19660	COG4715	Zinc finger, swim domain protein
A4A60_19665	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4A60_19670	COG0561	phosphatase activity
A4A60_19675	COG1349	DNA-binding transcription factor activity
A4A60_19680	COG0629	single-stranded DNA binding
A4A60_19695	COG3764	Sortase (surface protein transpeptidase)
A4A60_19700	COG0745	RESPONSE REGULATOR receiver
A4A60_19700	COG2972	Histidine kinase
A4A60_19705	COG1970	mechanosensitive ion channel activity
A4A60_19710	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A4A60_19715	COG0457	Tetratricopeptide repeat
A4A60_19720	COG4786	Flagellar basal body rod
A4A60_19725	COG4786	Flagellar basal body rod
A4A60_19730	COG1077	Cell shape determining protein MreB Mrl
A4A60_19735	COG1609	Transcriptional regulator
A4A60_19740	COG1846	Transcriptional regulator
A4A60_19745	COG2814	Major facilitator Superfamily
A4A60_19750	COG3420	alginic acid biosynthetic process
A4A60_19755	COG1953	Uracil, thiamine, allantoin
A4A60_19760	COG0477	Major facilitator Superfamily
A4A60_19765	COG1335	isochorismatase
A4A60_19775	COG0004	ammonium transporteR
A4A60_19780	COG0347	Belongs to the P(II) protein family
A4A60_19785	COG0671	phosphoesterase, PA-phosphatase related
A4A60_19795	COG0739	heme binding
A4A60_19800	COG1247	-acetyltransferase
A4A60_19810	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A4A60_19820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4A60_19825	COG0789	Transcriptional regulator
A4A60_19840	COG1959	2 iron, 2 sulfur cluster binding
A4A60_19845	COG0804	urea catabolic process
A4A60_19850	COG0832	Belongs to the urease beta subunit family
A4A60_19855	COG0831	urea catabolic process
A4A60_19865	COG3237	CsbD-like
A4A60_19870	COG1994	Peptidase M50
A4A60_19875	COG0457	Tetratricopeptide repeat
A4A60_19880	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A4A60_19885	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A4A60_19895	COG2304	oxidoreductase activity
A4A60_19905	COG2304	oxidoreductase activity
A4A60_19910	COG2385	sporulation resulting in formation of a cellular spore
A4A60_19915	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A4A60_19925	COG4836	Membrane
A4A60_19935	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A4A60_19940	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A4A60_19945	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A4A60_19950	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A4A60_19955	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4A60_19960	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A4A60_19970	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4A60_19975	COG0356	it plays a direct role in the translocation of protons across the membrane
A4A60_19985	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A4A60_19990	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A4A60_19995	COG4475	Protein of unknown function (DUF436)
A4A60_20000	COG0698	ribose 5-phosphate isomerase
A4A60_20005	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4A60_20010	COG1971	Probably functions as a manganese efflux pump
A4A60_20015	COG0009	L-threonylcarbamoyladenylate synthase
A4A60_20020	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A4A60_20040	COG2890	protein-(glutamine-N5) methyltransferase activity
A4A60_20045	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A4A60_20050	COG0346	lactoylglutathione lyase activity
A4A60_20055	COG0789	Transcriptional regulator
A4A60_20060	COG0679	Auxin Efflux Carrier
A4A60_20065	COG0281	malic enzyme
A4A60_20070	COG1435	thymidine kinase activity
A4A60_20075	COG0254	rRNA binding
A4A60_20080	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A4A60_20090	COG1494	fructose-1,6-bisphosphatase
A4A60_20095	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A4A60_20100	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A4A60_20105	COG0191	fructose-bisphosphate aldolase activity
A4A60_20110	COG2204	response regulator
A4A60_20115	COG4821	SIS domain
A4A60_20120	COG2801	Transposase and inactivated derivatives
A4A60_20130	COG0504	CTP synthase activity
A4A60_20135	COG3343	RNA polymerase activity
A4A60_20140	COG1960	acyl-CoA dehydrogenase activity
A4A60_20145	COG0247	lactate metabolic process
A4A60_20145	COG2181	nitrate reductase activity
A4A60_20150	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A4A60_20155	COG4294	response to UV
A4A60_20175	COG0018	arginyl-trna synthetase
A4A60_20180	COG4506	Protein conserved in bacteria
A4A60_20190	COG0535	radical SAM domain protein
A4A60_20200	COG1131	(ABC) transporter
A4A60_20205	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A4A60_20210	COG0612	Peptidase, M16
A4A60_20215	COG0612	Peptidase, M16
A4A60_20225	COG3391	amine dehydrogenase activity
A4A60_20240	COG0457	Tetratricopeptide repeat
A4A60_20255	COG0010	Belongs to the arginase family
A4A60_20260	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
A4A60_20265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4A60_20280	COG1994	Peptidase M50
A4A60_20285	COG1942	4-Oxalocrotonate Tautomerase
A4A60_20290	COG1846	Transcriptional regulator
A4A60_20295	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A4A60_20305	COG0477	Major facilitator Superfamily
A4A60_20310	COG1959	2 iron, 2 sulfur cluster binding
A4A60_20315	COG3465	dGTPase activity
A4A60_20320	COG1078	dGTPase activity
A4A60_20325	COG4844	belongs to the
A4A60_20335	COG0697	spore germination
A4A60_20340	COG0095	Lipoate-protein ligase
A4A60_20345	COG0583	DNA-binding transcription factor activity
A4A60_20350	COG0280	phosphate acetyltransferase
A4A60_20360	COG1028	Short-chain dehydrogenase reductase Sdr
A4A60_20365	COG0436	Aminotransferase
A4A60_20370	COG2814	Major facilitator Superfamily
A4A60_20375	COG0151	Belongs to the GarS family
A4A60_20380	COG1028	Short-chain dehydrogenase reductase Sdr
A4A60_20385	COG1917	Cupin 2, conserved barrel domain protein
A4A60_20390	COG0077	Prephenate dehydratase
A4A60_20395	COG2814	Major facilitator Superfamily
A4A60_20400	COG0833	amino acid
A4A60_20405	COG4187	Peptidase family M20/M25/M40
A4A60_20410	COG1012	belongs to the aldehyde dehydrogenase family
A4A60_20415	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A4A60_20425	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A4A60_20430	COG1091	dTDP-4-dehydrorhamnose reductase activity
A4A60_20435	COG1088	dTDP-glucose 4,6-dehydratase activity
A4A60_20440	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A4A60_20445	COG3980	spore coat polysaccharide biosynthesis protein
A4A60_20450	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
A4A60_20455	COG2089	acid synthase
A4A60_20460	COG0456	acetyltransferase
A4A60_20465	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A4A60_20470	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
A4A60_20475	COG0463	Glycosyl transferase, family 2
A4A60_20490	COG2363	Small membrane protein
A4A60_20495	COG2233	PERMEase
A4A60_20505	COG1012	belongs to the aldehyde dehydrogenase family
A4A60_20510	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A4A60_20515	COG1216	Glycosyl transferase, family 2
A4A60_20520	COG0351	phosphomethylpyrimidine kinase
A4A60_20530	COG1621	beta-fructofuranosidase activity
A4A60_20535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4A60_20535	COG1263	PTS System
A4A60_20540	COG2116	formate transmembrane transporter activity
A4A60_20545	COG3711	transcriptional antiterminator
A4A60_20555	COG1404	Belongs to the peptidase S8 family
A4A60_20560	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
A4A60_20565	COG0778	Nitroreductase
A4A60_20570	COG0772	Belongs to the SEDS family
A4A60_20585	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
A4A60_20590	COG1845	cytochrome c oxidase, subunit III
A4A60_20595	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
A4A60_20600	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
A4A60_20605	COG2261	transglycosylase associated protein
A4A60_20610	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A4A60_20615	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A4A60_20620	COG2246	polysaccharide biosynthetic process
A4A60_20625	COG1309	transcriptional regulator
A4A60_20635	COG3162	membrane
A4A60_20640	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4A60_20645	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
A4A60_20650	COG2837	iron assimilation
A4A60_20655	COG2822	iron ion transport
A4A60_20660	COG0672	)-iron permease
A4A60_20665	COG0352	thiamine-phosphate diphosphorylase activity
A4A60_20670	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A4A60_20675	COG0583	DNA-binding transcription factor activity
A4A60_20680	COG1380	Effector of murein hydrolase LrgA
A4A60_20685	COG1346	cytolysis
A4A60_20690	COG2814	Major facilitator Superfamily
A4A60_20695	COG4895	conserved protein (DUF2196)
A4A60_20700	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A4A60_20705	COG0346	lactoylglutathione lyase activity
A4A60_20715	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4A60_20725	COG1263	PTS System
A4A60_20725	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A4A60_20730	COG3711	transcriptional antiterminator
A4A60_20740	COG1442	glycosyl transferase family 8
A4A60_20745	COG5522	Integral membrane protein (intg_mem_TP0381)
A4A60_20750	COG1846	Transcriptional regulator
A4A60_20755	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A4A60_20760	COG2234	aminopeptidase activity
A4A60_20765	COG2357	RelA SpoT domain protein
A4A60_20775	COG2801	Transposase and inactivated derivatives
A4A60_20780	COG1575	Belongs to the MenA family. Type 1 subfamily
A4A60_20795	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A4A60_20800	COG1696	Membrane protein involved in D-alanine export
A4A60_20805	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4A60_20810	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A4A60_20820	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4A60_20825	COG1486	melibiose metabolic process
A4A60_20830	COG1447	Phosphotransferase system cellobiose-specific component IIA
A4A60_20835	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4A60_20840	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A4A60_20845	COG3711	transcriptional antiterminator
A4A60_20845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4A60_20855	COG2094	Belongs to the DNA glycosylase MPG family
A4A60_20860	COG0753	catalase activity
A4A60_20865	COG2814	Major facilitator Superfamily
A4A60_20870	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
A4A60_20875	COG1131	(ABC) transporter
A4A60_20895	COG1595	DNA-templated transcription, initiation
A4A60_20900	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
A4A60_20905	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A4A60_20910	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
A4A60_20915	COG4988	ABC transporter
A4A60_20920	COG1294	oxidase, subunit
A4A60_20925	COG1271	oxidase subunit
A4A60_20930	COG3493	citrate carrier protein
A4A60_20935	COG0501	Belongs to the peptidase M48B family
A4A60_20945	COG0726	polysaccharide deacetylase
A4A60_20950	COG3842	ATPase activity
A4A60_20955	COG2508	Transcriptional regulator
A4A60_20960	COG1012	belongs to the aldehyde dehydrogenase family
A4A60_20965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A4A60_20975	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A4A60_20990	COG2197	response regulator
A4A60_20995	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4A60_21010	COG4894	glucomannan catabolic process
A4A60_21015	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A4A60_21020	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A4A60_21025	COG1028	Short-chain dehydrogenase reductase Sdr
A4A60_21030	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
A4A60_21035	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
A4A60_21040	COG2610	gluconate transmembrane transporter activity
A4A60_21050	COG0500	methyltransferase
A4A60_21055	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A4A60_21070	COG0693	protein deglycase activity
A4A60_21070	COG0753	catalase activity
A4A60_21075	COG2851	Citrate transporter
A4A60_21080	COG2273	Hydrolase Family 16
A4A60_21085	COG3711	transcriptional antiterminator
A4A60_21095	COG2270	Major facilitator Superfamily
A4A60_21100	COG0513	Belongs to the DEAD box helicase family
A4A60_21105	COG2755	lipolytic protein G-D-S-L family
A4A60_21105	COG3401	FG-GAP repeat protein
A4A60_21220	COG0697	spore germination
A4A60_21235	COG0589	response to stress
A4A60_21255	COG5444	nuclease activity
A4A60_21275	COG0494	nUDIX hydrolase
A4A60_21280	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
A4A60_21285	COG3507	Belongs to the glycosyl hydrolase 43 family
A4A60_21290	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
A4A60_21300	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A4A60_21305	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A4A60_21310	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A4A60_21315	COG2390	Transcriptional regulator
A4A60_21325	COG3192	ethanolamine utilization protein
A4A60_21330	COG2079	MmgE PrpD family protein
A4A60_21340	COG1126	abc transporter atp-binding protein
A4A60_21345	COG0765	amino acid transport
A4A60_21350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4A60_21365	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
A4A60_21370	COG0561	phosphatase activity
A4A60_21400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A4A60_21405	COG5294	Protein conserved in bacteria
A4A60_21410	COG0577	efflux transmembrane transporter activity
A4A60_21415	COG1136	(ABC) transporter
A4A60_21420	COG2205	protein histidine kinase activity
A4A60_21425	COG0745	RESPONSE REGULATOR receiver
A4A60_21430	COG0191	fructose-bisphosphate aldolase activity
A4A60_21435	COG1082	Xylose isomerase domain protein TIM barrel
A4A60_21440	COG1082	Xylose isomerase domain protein TIM barrel
A4A60_21445	COG0673	inositol 2-dehydrogenase activity
A4A60_21450	COG2814	Major facilitator Superfamily
A4A60_21455	COG1082	Xylose isomerase domain protein TIM barrel
A4A60_21460	COG3962	Belongs to the TPP enzyme family
A4A60_21465	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
A4A60_21480	COG1349	DNA-binding transcription factor activity
A4A60_21485	COG0667	Aldo Keto reductase
A4A60_21515	COG0326	Molecular chaperone. Has ATPase activity
A4A60_21530	COG1309	transcriptional regulator
A4A60_21535	COG1012	belongs to the aldehyde dehydrogenase family
A4A60_21540	COG1714	RDD family
A4A60_21550	COG1714	RDD family
A4A60_21555	COG2311	Membrane
A4A60_21560	COG1917	Cupin 2, conserved barrel domain protein
A4A60_21565	COG1309	transcriptional regulator
A4A60_21570	COG1028	Short-chain dehydrogenase reductase Sdr
A4A60_21575	COG1846	Transcriptional regulator
A4A60_21580	COG1380	Effector of murein hydrolase LrgA
A4A60_21585	COG1346	cytolysis
A4A60_21590	COG5039	Polysaccharide pyruvyl transferase
A4A60_21595	COG1929	Belongs to the glycerate kinase type-1 family
A4A60_21600	COG1802	Transcriptional regulator
A4A60_21605	COG1070	Carbohydrate kinase
A4A60_21610	COG2610	gluconate transmembrane transporter activity
A4A60_21615	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A4A60_21620	COG0450	alkyl hydroperoxide reductase
A4A60_21625	COG3634	alkyl hydroperoxide reductase activity
A4A60_21630	COG2723	6-phospho-beta-galactosidase activity
A4A60_21640	COG2188	Transcriptional regulator
A4A60_21650	COG1131	(ABC) transporter
A4A60_21655	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
A4A60_21670	COG0071	Belongs to the small heat shock protein (HSP20) family
A4A60_21700	COG0210	DNA helicase
A4A60_21710	COG2801	Transposase and inactivated derivatives
A4A60_21715	COG2963	transposase activity
A4A60_21750	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A4A60_21760	COG1063	alcohol dehydrogenase
A4A60_21780	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
A4A60_21785	COG0456	acetyltransferase
A4A60_21800	COG0010	Belongs to the arginase family
A4A60_21805	COG0833	amino acid
A4A60_21810	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4A60_21830	COG5658	integral membrane protein
A4A60_21835	COG0640	Transcriptional regulator
A4A60_21840	COG3829	transcription factor binding
A4A60_21850	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4A60_21855	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A4A60_21860	COG4853	Protein conserved in bacteria
A4A60_21865	COG4863	YycH protein
A4A60_21870	COG5002	protein histidine kinase activity
A4A60_21875	COG0745	RESPONSE REGULATOR receiver
A4A60_21905	COG0346	lactoylglutathione lyase activity
A4A60_21910	COG0305	Participates in initiation and elongation during chromosome replication
A4A60_21930	COG3093	addiction module antidote protein HigA
A4A60_21935	COG2807	transmembrane transport
A4A60_21940	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
A4A60_21945	COG0359	binds to the 23S rRNA
A4A60_21950	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
A4A60_21970	COG1733	regulation of RNA biosynthetic process
A4A60_21975	COG1227	inorganic diphosphatase activity
A4A60_21995	COG4978	Transcriptional regulator
A4A60_21995	COG0789	Transcriptional regulator
A4A60_22005	COG4319	ketosteroid isomerase
A4A60_22010	COG1357	PFAM Pentapeptide repeats (8 copies)
A4A60_22025	COG1846	Transcriptional regulator
A4A60_22030	COG2153	protein acetylation
A4A60_22035	COG2364	Membrane
A4A60_22050	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
A4A60_22055	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
A4A60_22060	COG1331	Highly conserved protein containing a thioredoxin domain
A4A60_22065	COG1266	CAAX protease self-immunity
A4A60_22070	COG0477	Major facilitator Superfamily
A4A60_22070	COG2814	Major facilitator Superfamily
A4A60_22075	COG0110	maltose O-acetyltransferase activity
A4A60_22080	COG0346	lactoylglutathione lyase activity
A4A60_22090	COG0708	Exodeoxyribonuclease III
A4A60_22095	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A4A60_22100	COG0629	single-stranded DNA binding
A4A60_22105	COG0360	Binds together with S18 to 16S ribosomal RNA
A4A60_22110	COG0012	GTP binding
A4A60_22115	COG0243	molybdopterin cofactor binding
A4A60_22120	COG4481	Protein conserved in bacteria
A4A60_22125	COG3949	Membrane
A4A60_22140	COG2801	Transposase and inactivated derivatives
A4A60_22145	COG1475	DNA binding
A4A60_22150	COG1192	Involved in chromosome partitioning
A4A60_22160	COG1475	DNA binding
A4A60_22165	COG0357	Ribosomal RNA small subunit methyltransferase G
A4A60_22170	COG0445	tRNA wobble uridine modification
A4A60_22175	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A4A60_22180	COG1847	R3H domain protein
A4A60_22185	COG0706	membrane insertase activity
A4A60_22190	COG0594	ribonuclease P activity
A4A60_22195	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A4A60_22200	COG0457	Tetratricopeptide repeat