locus-tag class description BHE96_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BHE96_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BHE96_00015 ENOG410848D S4 domain protein YaaA BHE96_00020 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BHE96_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BHE96_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BHE96_00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BHE96_00080 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) BHE96_00085 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) BHE96_00090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BHE96_00095 ENOG4105BZW Glycerate kinase BHE96_00105 ENOG4105ZMH deoxynucleoside kinase BHE96_00115 ENOG4105VRS hydrolase family 18 BHE96_00120 ENOG4105GTG Isochorismatase BHE96_00125 ENOG4108Z6B deaminase BHE96_00135 ENOG4105C6E dna polymerase iii BHE96_00140 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BHE96_00145 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) BHE96_00155 ENOG41067KS pro-sigma K processing BHE96_00195 ENOG4105CDW Resistance protein BHE96_00200 ENOG4105CXN decarboxylase BHE96_00205 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) BHE96_00210 ENOG4105X0R protein from nitrogen regulatory protein P-II BHE96_00215 ENOG4105XVJ Protein of unknown function (DUF327) BHE96_00220 ENOG4105FA2 dna polymerase iii BHE96_00225 ENOG4105MA4 psp1 domain protein BHE96_00235 ENOG41060K3 Methyltransferase BHE96_00240 ENOG4105VC4 domain protein BHE96_00245 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BHE96_00250 ENOG4105KRN Transcriptional regulator, abrb family BHE96_00255 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BHE96_00260 ENOG4105F8V Hydrolase, tatD family BHE96_00265 ENOG41069ER domain protein BHE96_00275 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BHE96_00280 ENOG4105XFA sporulation peptidase YabG BHE96_00285 ENOG4105W42 Veg protein BHE96_00290 ENOG4105XEW small acid-soluble spore protein BHE96_00295 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BHE96_00300 ENOG4105DFT pur operon repressor BHE96_00305 ENOG4105KME endoribonuclease L-psp BHE96_00310 ENOG4105K4W Could be involved in septation (By similarity) BHE96_00315 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) BHE96_00320 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BHE96_00325 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BHE96_00340 ENOG4108JA2 transcriptioN-repair coupling factor BHE96_00345 ENOG4108M14 stage v sporulation protein t BHE96_00355 ENOG4108IY2 MazG family BHE96_00360 ENOG41082I2 s4 domain protein BHE96_00365 ENOG4105VYY sporulation protein yabp BHE96_00380 ENOG41060GV RNA binding s1 domain protein BHE96_00410 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BHE96_00415 ENOG4108UGV hypoxanthine phosphoribosyltransferase BHE96_00420 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BHE96_00425 ENOG4105CGM Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity) BHE96_00430 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) BHE96_00435 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase BHE96_00440 ENOG4105C6T cysteine synthase BHE96_00445 ENOG4105CRQ synthase (Component I) BHE96_00450 ENOG4105DDQ anthranilate synthase BHE96_00455 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 BHE96_00460 ENOG4105EEI dihydropteroate synthase BHE96_00465 ENOG4105KRF dihydroneopterin aldolase BHE96_00470 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BHE96_00480 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BHE96_00485 ENOG4105CRK lysyL-tRNA synthetase BHE96_00570 ENOG4108Z0C Uvrb UvrC protein BHE96_00575 ENOG41066A3 ATP guanido phosphotransferase BHE96_00585 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BHE96_00590 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) BHE96_00595 ENOG4105CTP PilT protein domain protein BHE96_00600 ENOG4108QHG Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) BHE96_00605 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) BHE96_00610 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BHE96_00615 ENOG4105D7W serine acetyltransferase BHE96_00625 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) BHE96_00630 ENOG4105C2N RNA methyltransferase TrmH family group 3 BHE96_00635 ENOG4105M0M Tetracycline resistance protein BHE96_00655 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BHE96_00660 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) BHE96_00670 ENOG4108VZM 50s ribosomal protein L10 BHE96_00675 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BHE96_00680 ENOG4107Y49 methyltransferase BHE96_00685 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BHE96_00690 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BHE96_00695 ENOG4105XPM ribosomal protein BHE96_00700 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) BHE96_00705 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BHE96_00710 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BHE96_00715 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BHE96_00720 ENOG4107SKW Inherit from COG: Alpha beta hydrolase BHE96_00725 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) BHE96_00730 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BHE96_00735 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BHE96_00740 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BHE96_00745 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity BHE96_00750 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BHE96_00755 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BHE96_00760 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) BHE96_00765 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BHE96_00770 ENOG41082SA 50s ribosomal protein l29 BHE96_00775 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal BHE96_00790 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BHE96_00800 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BHE96_00805 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BHE96_00810 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BHE96_00815 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BHE96_00820 ENOG4105VPB 50S ribosomal protein L30 BHE96_00825 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BHE96_00830 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BHE96_00835 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BHE96_00840 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BHE96_00850 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) BHE96_00860 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits BHE96_00865 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BHE96_00870 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BHE96_00875 ENOG4108ZT0 50S ribosomal protein l17 BHE96_00880 ENOG4108JJB ABC transporter BHE96_00885 ENOG4108JJB ABC transporter BHE96_00890 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) BHE96_00895 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BHE96_00900 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BHE96_00905 ENOG4108UJD 30S ribosomal protein S9 BHE96_00910 ENOG4108I0C methyltransferase BHE96_00930 ENOG4105D1F ATP-binding protein BHE96_00945 ENOG4108NMV polysaccharide deacetylase BHE96_01010 ENOG4108JPW Aminotransferase BHE96_01025 ENOG4105CHH sulfate transporter BHE96_01035 ENOG4108SA1 esterase BHE96_01055 ENOG410874W AraC family transcriptional regulator BHE96_01060 ENOG4105EHZ conserved protein UCP016719 BHE96_01065 ENOG4105D17 glycoside hydrolase, family 3 domain protein BHE96_01080 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BHE96_01090 ENOG4105EWC Purine nucleoside phosphorylase BHE96_01120 ENOG4105EMN RNA polymerase sigma factor BHE96_01130 ENOG4105C8B TIGR00159 family BHE96_01135 ENOG4107U5W ybbr family BHE96_01140 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BHE96_01165 ENOG4106K80 BHE96_01175 ENOG41067MG lrgb family BHE96_01185 ENOG41061AU MarR family Transcriptional regulator BHE96_01200 ENOG4105BZU Histidine kinase BHE96_01205 ENOG4105WH1 Two component transcriptional regulator luxr family BHE96_01210 ENOG4105CJ1 ABC, transporter BHE96_01235 ENOG4106DDH Sporulation-specific SASP protein BHE96_01250 ENOG4107QTZ amino acid BHE96_01255 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) BHE96_01270 ENOG4107VXM glycerophosphoryl diester phosphodiesterase BHE96_01275 ENOG4105CXY transporter BHE96_01315 ENOG4107SCQ Iron-containing alcohol dehydrogenase BHE96_01320 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR BHE96_01325 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase BHE96_01330 ENOG4107ZTW SNARE associated Golgi BHE96_01345 ENOG4105C72 UPF0176 protein BHE96_01355 ENOG4105CM2 brancheD-chain amino acid aminotransferase BHE96_01360 ENOG4108IQI permease BHE96_01365 ENOG4108J5H Homocysteine s-methyltransferase BHE96_01375 ENOG4105CSV Glutaminase BHE96_01405 ENOG41076HS cation diffusion facilitator family transporter BHE96_01410 ENOG4108TVJ Nitroreductase BHE96_01415 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase BHE96_01420 ENOG4108VGI doxx family BHE96_01425 ENOG4105XXY Thioredoxin BHE96_01450 ENOG4105DGI Alkaline phosphatase BHE96_01455 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BHE96_01460 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BHE96_01465 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) BHE96_01470 ENOG4107EPV Aminotransferase class V BHE96_01475 ENOG4105C0R drug resistance transporter emrb qaca subfamily BHE96_01480 ENOG4105J7D transcriptional regulator BHE96_01485 ENOG4107RB3 L-asparaginase BHE96_01490 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold BHE96_01495 ENOG41060AI SEC-C motif BHE96_01500 ENOG4107SET aldo keto reductase BHE96_01530 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BHE96_01545 ENOG4105U3E Transcriptional regulator BHE96_01550 ENOG4105DSE periplasmic solute binding protein BHE96_01555 ENOG4105DIK (ABC) transporter BHE96_01565 ENOG4105DEN Luciferase family BHE96_01570 ENOG4108N0M stress protein BHE96_01575 ENOG4106FN3 tellurium resistance protein BHE96_01580 ENOG4106FN3 tellurium resistance protein BHE96_01585 ENOG4107TS3 membrane protein, TerC BHE96_01590 ENOG4108TTB tellurium resistance protein BHE96_01600 ENOG41079KZ Major Facilitator Superfamily BHE96_01605 ENOG4108IJ7 Glycine betaine BHE96_01610 ENOG4107SQ8 Glycine betaine BHE96_01640 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) BHE96_01670 ENOG4105EIG urea carboxylase-associated protein 1 BHE96_01675 ENOG4107RA1 nh(3)-dependent nad( ) synthetase BHE96_01680 ENOG4105DQ6 Transposase BHE96_01695 ENOG4105I1F Resistance protein BHE96_01700 ENOG4108WBH protein TIM barrel BHE96_01705 ENOG4105DJB Major Facilitator Superfamily BHE96_01710 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BHE96_01715 ENOG4105I82 acetyl xylan esterase BHE96_01720 ENOG410756H nucleotidyltransferase BHE96_01730 ENOG4105C26 Dehydrogenase BHE96_01735 ENOG4105CK7 Sodium proline symporter BHE96_01740 ENOG4107YHD transcriptional regulator BHE96_01745 ENOG4105CAY ferredoxin--nadp reductase BHE96_01750 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BHE96_01755 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit BHE96_01760 ENOG4108IFG nitrite reductase, (NAD(P)H) BHE96_01765 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BHE96_01780 ENOG4105CKI cobalamin synthesis protein BHE96_01785 ENOG4105E2A Dehydrogenase BHE96_01790 ENOG4105HHM rdd domain containing protein BHE96_01800 ENOG4105CS2 ec 3.2.1.21 BHE96_01815 ENOG41080HJ 6-phospho 3-hexuloisomerase BHE96_01820 ENOG4108VA3 3-hexulose-6-phosphate synthase BHE96_01825 ENOG4105KVH Transcriptional regulator BHE96_01835 ENOG4105CEY Amp-dependent synthetase and ligase BHE96_01855 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BHE96_01865 ENOG4105SX7 Transporter BHE96_01885 ENOG4105CDA abc transporter atp-binding protein BHE96_01890 ENOG4105DRP amino acid AbC transporter BHE96_01900 ENOG4106P55 Transcriptional regulator BHE96_01905 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase BHE96_01910 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) BHE96_01915 ENOG41069ZX BHE96_01925 ENOG4105DUX Transporter BHE96_01940 ENOG4105E1K spore germination protein BHE96_01955 ENOG4105CPU Monooxygenase BHE96_01960 ENOG4108XSB acetyltransferase, (GNAT) family BHE96_01965 ENOG4105EAB amino acid AbC transporter BHE96_01970 ENOG4108HW4 amino acid AbC transporter BHE96_01980 ENOG4105CH2 amidohydrolase BHE96_01985 ENOG4108PGP mmge prpd family protein BHE96_01995 ENOG4107WD8 ABC transporter, permease BHE96_02000 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BHE96_02005 ENOG4105BZU Histidine kinase BHE96_02025 ENOG4105CFH Aspartokinase BHE96_02030 ENOG4105DHS permease protein BHE96_02035 ENOG4105CM4 permease protein BHE96_02040 ENOG4108IPW abc transporter atp-binding protein BHE96_02055 ENOG4105R8C Transcriptional regulator BHE96_02060 ENOG4108DBC nitroreductase BHE96_02065 ENOG41067V3 Antibiotic biosynthesis monooxygenase BHE96_02070 ENOG4105YVS arsR family transcriptional regulator BHE96_02080 ENOG4108JPW Aminotransferase BHE96_02085 ENOG4105C26 Dehydrogenase BHE96_02095 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BHE96_02100 ENOG4105KTB nuclear export factor GLE1 BHE96_02105 ENOG4108T5E Copper resistance protein BHE96_02110 ENOG4108ZYE Transcriptional regulator BHE96_02130 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase BHE96_02145 ENOG4105E7W lamb ycsf family protein BHE96_02150 ENOG4105C5A transporter BHE96_02155 ENOG4105CFM UPF0317 protein BHE96_02160 ENOG4105P4J Allophanate hydrolase, subunit 1 BHE96_02170 ENOG4107258 Transcriptional regulator BHE96_02175 ENOG4105XJB lipolytic protein G-D-S-L family BHE96_02185 ENOG41061CK Antibiotic biosynthesis monooxygenase BHE96_02190 ENOG4107RVG penicillin-binding protein BHE96_02195 ENOG4107QM2 Aldo Keto reductase BHE96_02200 ENOG4105ETD TRANSCRIPTIONal BHE96_02210 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BHE96_02225 ENOG410606W general stress protein BHE96_02240 ENOG4105DQ6 Transposase BHE96_02245 ENOG4105VCH membrane BHE96_02255 ENOG4105C9U ATP-dependent DNA helicase RecQ BHE96_02270 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) BHE96_02275 ENOG4107R8N Glycosyl transferase, family 2 BHE96_02285 ENOG4105C0X amino acid BHE96_02325 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) BHE96_02340 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) BHE96_02345 ENOG4105RXJ BHE96_02350 ENOG4105KPY Small multidrug resistance protein BHE96_02355 ENOG4105EU9 BHE96_02360 ENOG4105QVS general stress protein BHE96_02365 ENOG41082W1 Cupin 2, conserved barrel domain protein BHE96_02380 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BHE96_02385 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BHE96_02390 ENOG4108MRH transcriptional regulatory protein BHE96_02395 ENOG4107QJT sodium dicarboxylate symporter BHE96_02400 ENOG4106F5Q Membrane BHE96_02405 ENOG4105CJ1 ABC, transporter BHE96_02420 ENOG4105FDT acyl-CoA dehydrogenase BHE96_02440 ENOG4105SZ6 Thioredoxin BHE96_02445 ENOG4105CPF Cell wall formation (By similarity) BHE96_02450 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) BHE96_02455 ENOG4105C1J atp-dependent rna helicase BHE96_02460 ENOG410905X membrane-flanked domain protein BHE96_02465 ENOG4105CKV Membrane BHE96_02475 ENOG4107ZSJ Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) BHE96_02480 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein BHE96_02485 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BHE96_02495 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) BHE96_02500 ENOG4107MMM Anti-sigma-factor antagonist BHE96_02505 ENOG4105FUA antagonist BHE96_02510 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase BHE96_02515 ENOG4107SGM protein serine threonine phosphatase BHE96_02520 ENOG4105WN5 stage II sporulation protein BHE96_02525 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BHE96_02535 ENOG41064BQ Phosphatase BHE96_02545 ENOG410906U SprT-like BHE96_02615 ENOG410847I Transcriptional regulator, BadM Rrf2 family BHE96_02620 ENOG4107YCK Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BHE96_02625 ENOG4105ECP epimerase BHE96_02630 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BHE96_02645 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BHE96_02665 ENOG4105C94 Transporter BHE96_02670 ENOG4105CSH Transporter BHE96_02685 ENOG4108ZMQ domain protein BHE96_02700 ENOG4108Z40 Transcriptional regulator BHE96_02705 ENOG4108RYK Nad-dependent epimerase dehydratase BHE96_02710 ENOG4105M4P Tetr family transcriptional regulator BHE96_02715 ENOG4105E1F short-chain dehydrogenase reductase BHE96_02720 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BHE96_02735 ENOG4105VEQ Cold shock protein BHE96_02740 ENOG4108VJ1 Transcriptional regulator (CarD family BHE96_02760 ENOG410645S MarR family Transcriptional regulator BHE96_02765 ENOG4105DCM major facilitator superfamily BHE96_02770 ENOG4105IRW patatin-like phospholipase family protein BHE96_02780 ENOG41082W1 Cupin 2, conserved barrel domain protein BHE96_02795 ENOG4105DNP FAD linked oxidase domain protein BHE96_02805 ENOG4105PGM cation diffusion facilitator family transporter BHE96_02810 ENOG4105H3G oxidoreductase BHE96_02820 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein BHE96_02830 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BHE96_02855 ENOG4105DQ4 alcohol dehydrogenase BHE96_02860 ENOG4105VUF Transcriptional regulator BHE96_02870 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BHE96_02905 ENOG4105EQ0 Major Facilitator superfamily BHE96_02910 ENOG4108JGH Tetr family transcriptional regulator BHE96_02915 ENOG4105T38 integral membrane protein BHE96_02920 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BHE96_02935 ENOG4105E2A Dehydrogenase BHE96_02940 ENOG4105PGS Spore coat protein BHE96_02950 ENOG4106UW1 Major Facilitator superfamily BHE96_02960 ENOG4108UW5 maltose o-acetyltransferase BHE96_02965 ENOG4105ENE Histidine kinase BHE96_02970 ENOG4108VB1 regulatoR BHE96_02975 ENOG4105EYF MMPL domain protein BHE96_02995 ENOG4108JYZ YitT family BHE96_03005 ENOG4105C2C drug resistance transporter, Bcr CflA BHE96_03010 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BHE96_03030 ENOG41090E6 transcriptional regulator MERR family BHE96_03045 ENOG4105EBM Alpha Beta Hydrolase Fold protein BHE96_03050 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BHE96_03055 ENOG4105DRR Transcriptional regulator, GntR family BHE96_03075 ENOG4105FQP Beta-lactamase BHE96_03080 ENOG41090UD (LipO)protein BHE96_03085 ENOG4108SUT Major Facilitator Superfamily BHE96_03090 ENOG4108TZY GntR Family Transcriptional Regulator BHE96_03095 ENOG4105JXH GntR family transcriptional regulator BHE96_03100 ENOG4105DJ2 Major Facilitator Superfamily BHE96_03120 ENOG4107QTZ amino acid BHE96_03140 ENOG4107QNK )-transporter BHE96_03180 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BHE96_03185 ENOG4105K8N protein family UPF0079, ATPase BHE96_03190 ENOG41072GX Peptidase M22 Glycoprotease BHE96_03195 ENOG410801F ribosomal-protein-alanine acetyltransferase BHE96_03200 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BHE96_03205 ENOG4105C5H ABC transporter BHE96_03210 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BHE96_03215 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) BHE96_03220 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BHE96_03225 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BHE96_03235 ENOG4108TYN CAAX amino terminal protease family protein BHE96_03240 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BHE96_03245 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BHE96_03265 ENOG4105PGZ NB-ARC domain BHE96_03270 ENOG4105CPQ Dehydrogenase BHE96_03275 ENOG4105CT4 transporter BHE96_03290 ENOG41087YS Phage shock protein A BHE96_03295 ENOG4105DQX Zinc finger domain BHE96_03300 ENOG4108WV1 Pfam:DUF477 BHE96_03310 ENOG4105EXC Acyl-transferase BHE96_03315 ENOG4108P49 AntiSigma factor BHE96_03320 ENOG4105JVQ RNA Polymerase BHE96_03345 ENOG4107STQ Multicopper oxidase BHE96_03350 ENOG4105C85 amino acid BHE96_03360 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BHE96_03375 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BHE96_03390 ENOG4105C7N Xanthine uracil vitamin C permease BHE96_03415 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BHE96_03420 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BHE96_03425 ENOG4105C83 adenylosuccinate lyase BHE96_03430 ENOG4105C8V SAICAR synthetase BHE96_03435 ENOG4105VR9 phosphoribosylformylglycinamidine synthase BHE96_03440 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I BHE96_03445 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii BHE96_03455 ENOG4105CXB phosphoribosylaminoimidazole synthetase BHE96_03460 ENOG4108V3E phosphoribosylglycinamide formyltransferase BHE96_03465 ENOG4105DC1 bifunctional purine biosynthesis protein purh BHE96_03470 ENOG4105C12 Phosphoribosylglycinamide synthetase BHE96_03485 ENOG4108R5T secreted protein BHE96_03490 ENOG4105KGF protein, YerC YecD BHE96_03495 ENOG4105CBC glutamate synthase BHE96_03510 ENOG4105C4R Atp-dependent dna helicase BHE96_03515 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) BHE96_03525 ENOG4105CRN Aminoglycoside phosphotransferase BHE96_03530 ENOG4105KT7 mgtC SapB transporter BHE96_03535 ENOG4105CK7 Sodium proline symporter BHE96_03540 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BHE96_03545 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) BHE96_03550 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) BHE96_03555 ENOG4108IG5 Transcriptional regulator BHE96_03565 ENOG4105CBD Diacylglycerol kinase BHE96_03570 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BHE96_03575 ENOG4105CVR type I restriction-modification system BHE96_03580 ENOG4107XZC Restriction modification system DNA (Specificity BHE96_03585 ENOG4105DZR Type I site-specific deoxyribonuclease BHE96_03615 ENOG4106BHF BHE96_03620 ENOG4105CDY transcriptional regulatory protein BHE96_03640 ENOG4105WEF catalase BHE96_03645 ENOG4105M18 -acetyltransferase BHE96_03655 ENOG4105H67 Protein of unknown function (DUF421) BHE96_03660 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) BHE96_03665 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily BHE96_03685 ENOG4106I4J membrane BHE96_03690 ENOG41082F9 transcriptional regulator BHE96_03695 ENOG41061H0 Monooxygenase BHE96_03700 ENOG4108R1P BHE96_03705 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BHE96_03710 ENOG4105E0M Sulfatase BHE96_03715 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase BHE96_03725 ENOG41090R9 glycosyltransferase BHE96_03730 ENOG4107R51 Glycosyl transferase, family 2 BHE96_03735 ENOG41090R9 glycosyltransferase BHE96_03740 ENOG4105EU0 Major facilitator Superfamily BHE96_03745 ENOG4105CUB amino acid BHE96_03750 ENOG4105C26 Dehydrogenase BHE96_03755 ENOG4105FKZ Methyl-accepting chemotaxis BHE96_03760 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BHE96_03765 ENOG4107TVC Glycosyl transferase, family 2 BHE96_03770 ENOG4105C5H ABC transporter BHE96_03775 ENOG4107SWG transcriptional regulator MERR family BHE96_03780 ENOG4105DXB Major Facilitator superfamily BHE96_03785 ENOG4105C5H ABC transporter BHE96_03790 ENOG4105FDU atp-dependent rna helicase BHE96_03800 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BHE96_03815 ENOG4108J20 pectate lyase BHE96_03820 ENOG4107QPK )-transporter BHE96_03855 ENOG4108VAC response regulator BHE96_03865 ENOG4108Z6X (sortase) family BHE96_03875 ENOG4108MRH transcriptional regulatory protein BHE96_03900 ENOG41084X4 Acylphosphatase (EC 3.6.1.7) BHE96_03905 ENOG4108RPX mosc domain containing protein BHE96_03920 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) BHE96_03960 ENOG4105C5Y PTS System BHE96_03965 ENOG4105CG3 alpha amylase, catalytic region BHE96_03970 ENOG4107414 GntR family transcriptional regulator BHE96_03975 ENOG4108RCM Nitroreductase BHE96_03990 ENOG4105CGH 5'-nucleotidase BHE96_03995 ENOG4107RKG DJ-1/PfpI family BHE96_04000 ENOG4105ETE Transcriptional regulator (LacI family BHE96_04005 ENOG4105E2X shikimate dehydrogenase BHE96_04010 ENOG4105FF2 Type I DHQase BHE96_04025 ENOG4105KJF protein tyrosine phosphatase BHE96_04035 ENOG4107U9T Pfam:Ribonuclease_BN BHE96_04040 ENOG4108ISG Major Facilitator BHE96_04045 ENOG4105UPD Calcium Proton BHE96_04055 ENOG4105D8X mechanosensitive ion channel BHE96_04075 ENOG4106KE4 Dehydrogenase BHE96_04085 ENOG4105D7N magnesium and cobalt transport protein CorA BHE96_04095 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BHE96_04125 ENOG4107RUY (E1 component), alpha subunit BHE96_04135 ENOG4107QKR Dehydrogenase BHE96_04145 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family BHE96_04155 ENOG4105F8D glycoside hydrolase family 4 BHE96_04160 ENOG4108Q3X Transcriptional regulator BHE96_04165 ENOG4105CI1 PTS System BHE96_04175 ENOG4105BZ1 (ABC) transporter BHE96_04180 ENOG4105BZ1 (ABC) transporter BHE96_04190 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase BHE96_04200 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BHE96_04205 ENOG4105U3E Transcriptional regulator BHE96_04210 ENOG4105DYS nad(p)h dehydrogenase (quinone) BHE96_04215 ENOG4105H93 Acyltransferase family BHE96_04230 ENOG4108YYS metal-dependent hydrolase (By similarity) BHE96_04235 ENOG4105C0R drug resistance transporter emrb qaca subfamily BHE96_04240 ENOG410834F Transcriptional regulator BHE96_04250 ENOG4105JAB phenazine biosynthesis protein, phzf family BHE96_04255 ENOG4107Y03 Nitroreductase BHE96_04270 ENOG4105ECP epimerase BHE96_04275 ENOG410902V Modulates RecA activity (By similarity) BHE96_04285 ENOG4105F27 Major Facilitator BHE96_04295 ENOG4108TCS Glutamyl endopeptidase BHE96_04315 ENOG4106AKJ BHE96_04320 ENOG4105D74 hydrolase BHE96_04325 ENOG4105CKK Glycosyl transferase, family 2 BHE96_04330 ENOG4105EJV Membrane BHE96_04335 ENOG41067AE Membrane-bound metal-dependent hydrolase BHE96_04340 ENOG4105CEN a g-specific adenine glycosylase BHE96_04345 ENOG4106BXE BHE96_04350 ENOG4105CAN Short-chain dehydrogenase reductase Sdr BHE96_04370 ENOG4105BZ1 (ABC) transporter BHE96_04375 ENOG4107NBY Membrane BHE96_04385 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BHE96_04390 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BHE96_04395 ENOG4105G5W regulator Fur family BHE96_04400 ENOG4105TUA UPF0295 protein BHE96_04505 ENOG4107S6Z Na H antiporter BHE96_04510 ENOG4105EC3 peptidase S51, dipeptidase E BHE96_04515 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BHE96_04520 ENOG4105DNP FAD linked oxidase domain protein BHE96_04530 ENOG4105DEF Extracellular solute-binding protein, family 5 BHE96_04540 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BHE96_04545 ENOG4105C3U ABC transporter BHE96_04550 ENOG4108JQ7 (ABC) transporter BHE96_04565 ENOG4105E2Y ABC, transporter BHE96_04570 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein BHE96_04575 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BHE96_04585 ENOG41082QR Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BHE96_04590 ENOG4107D63 BHE96_04595 ENOG4105VZ8 Transcriptional regulator BHE96_04610 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BHE96_04620 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BHE96_04640 ENOG4105CYN Serine protein kinase BHE96_04655 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes BHE96_04660 ENOG4105CW7 secretion protein, HlyD family BHE96_04665 ENOG4105C0R drug resistance transporter emrb qaca subfamily BHE96_04670 ENOG4105CS1 NAD(P)H quinone oxidoreductase BHE96_04685 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family BHE96_04690 ENOG4105CZV ABC transporter BHE96_04695 ENOG4105CJ1 ABC, transporter BHE96_04700 ENOG4108TU7 Inherit from COG: (ABC) transporter BHE96_04705 ENOG4105VEQ Cold shock protein BHE96_04720 ENOG4105BZU Histidine kinase BHE96_04760 ENOG4108YBP pseudouridine synthase BHE96_04770 ENOG41080XP Cbs domain BHE96_04775 ENOG4107YBY Hydrolase BHE96_04780 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BHE96_04785 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BHE96_04790 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator BHE96_04800 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BHE96_04805 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BHE96_04815 ENOG4105BZU Histidine kinase BHE96_04820 ENOG4105WH1 Two component transcriptional regulator luxr family BHE96_04855 ENOG4105ED1 spovr family BHE96_04860 ENOG4105G6Z alkaline phosphatase BHE96_04875 ENOG4105BZN citrate synthase BHE96_04880 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BHE96_04885 ENOG4105CUB amino acid BHE96_04890 ENOG4105C8J )-transporter BHE96_04900 ENOG4105J37 BHE96_04905 ENOG4108AEY RNA polymerase sigma factor BHE96_04910 ENOG4105F6E Acyl-transferase BHE96_04915 ENOG4105C37 (CBS) domain BHE96_04925 ENOG4105CHM Aminotransferase BHE96_04930 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase BHE96_04935 ENOG4105C37 (CBS) domain BHE96_04945 ENOG4105WMR Protein CrcB homolog BHE96_04950 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BHE96_04955 ENOG4105D64 Mechanosensitive ion channel BHE96_04960 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BHE96_04965 ENOG4107VMI polysaccharide deacetylase BHE96_04970 ENOG4105F0I Aminotransferase BHE96_04975 ENOG4105W1N transcriptional regulator BHE96_04980 ENOG4105IIP Membrane BHE96_04990 ENOG4105BZ1 (ABC) transporter BHE96_04995 ENOG4105BZ1 (ABC) transporter BHE96_05020 ENOG410839P BHE96_05030 ENOG4106MP8 UPF0754 membrane protein BHE96_05035 ENOG4105WZB UPF0342 protein BHE96_05040 ENOG4105F1N DNA alkylation repair BHE96_05050 ENOG4105D4P Coproporphyrinogen iii oxidase BHE96_05060 ENOG4107S91 Sodium hydrogen exchanger BHE96_05065 ENOG4105NCW Trka-c domain protein BHE96_05075 ENOG4105CGU Enoyl-CoA hydratase BHE96_05085 ENOG4108IUX (ABC) transporter BHE96_05090 ENOG4105RHA ABC transporter, permease BHE96_05095 ENOG4107VRP DNA repair exonuclease BHE96_05100 ENOG4106D4I domain protein BHE96_05105 ENOG4105EQI Metal Dependent Phosphohydrolase BHE96_05115 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) BHE96_05165 ENOG4105NBU tryptophan transport protein BHE96_05170 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BHE96_05175 ENOG4105K59 histidine triad (HIT) protein BHE96_05205 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation BHE96_05210 ENOG4105BZ4 penicillin-binding protein BHE96_05215 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) BHE96_05220 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BHE96_05225 ENOG4105C1Q protoporphyrinogen oxidase BHE96_05235 ENOG4105ECB domain protein BHE96_05250 ENOG4105DER m42 family BHE96_05260 ENOG4106AXD BHE96_05265 ENOG4108RQ5 Beta-lactamase domain-containing protein BHE96_05270 ENOG4105DF9 Lipoate-protein, ligase BHE96_05280 ENOG4105CEY Amp-dependent synthetase and ligase BHE96_05290 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 BHE96_05305 ENOG4108HUF Transporter BHE96_05310 ENOG4107TB6 phosphoglycerate mutase BHE96_05320 ENOG4107F3J Amp-dependent synthetase and ligase BHE96_05325 ENOG4107ZYJ bioY protein BHE96_05330 ENOG4106YBV Methyl-accepting chemotaxis BHE96_05350 ENOG4105XVF Competence transcription factor BHE96_05370 ENOG4108ZMX Domain of unknown function (DU1801) BHE96_05385 ENOG4105X3H Excalibur domain protein BHE96_05390 ENOG4105K8R UPF0145 protein BHE96_05395 ENOG4105E1V na solute symporter BHE96_05400 ENOG4106CAD Protein of unknown function (DUF3311) BHE96_05405 ENOG41060YP BHE96_05420 ENOG4107SCK Monooxygenase BHE96_05425 ENOG4108INS Transcriptional regulator BHE96_05430 ENOG4108KK1 membrane protein AbrB duplication BHE96_05440 ENOG4108IG5 Transcriptional regulator BHE96_05450 ENOG4108QY0 Membrane BHE96_05455 ENOG4105C5N The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination BHE96_05460 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation BHE96_05470 ENOG4105EYH Exonuclease BHE96_05515 ENOG4105ERH Fumarylacetoacetate hydrolase BHE96_05535 ENOG4105CAQ asparagine synthetase BHE96_05545 ENOG4105UQX Mate efflux family protein BHE96_05550 ENOG4106HBX Transcriptional Regulator AraC Family BHE96_05555 ENOG4105SF0 DinB family BHE96_05560 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BHE96_05565 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BHE96_05570 ENOG4105MYW Pentapeptide repeat protein BHE96_05575 ENOG4105MA6 gCN5-related N-acetyltransferase BHE96_05585 ENOG4108VPT UPF0234 protein BHE96_05590 ENOG4105QNR S1 RNA binding domain protein BHE96_05595 ENOG4105DIH basic membrane BHE96_05600 ENOG4105C8Q Methyl-accepting chemotaxis BHE96_05605 ENOG4107E6A Cytochrome p-450 BHE96_05610 ENOG4105EPR degv family BHE96_05615 ENOG4107AYK membrAne BHE96_05625 ENOG41073B9 BHE96_05630 ENOG4108KP7 hydrolase BHE96_05635 ENOG4108MXZ Esterase BHE96_05640 ENOG4105VG1 fes assembly suf system protein BHE96_05645 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) BHE96_05650 ENOG4105IQ5 FAD linked oxidase domain protein BHE96_05660 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BHE96_05670 ENOG4105CAS nag kinase BHE96_05675 ENOG4105C8Y Acetylornithine aminotransferase BHE96_05680 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BHE96_05690 ENOG4105DBV ornithine carbamoyltransferase BHE96_05720 ENOG4107RMD Basic membrane lipoprotein BHE96_05735 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) BHE96_05740 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BHE96_05750 ENOG4105C3U ABC transporter BHE96_05770 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BHE96_05780 ENOG4105C31 Tryptophanyl-tRNA synthetase BHE96_05790 ENOG4108J59 Extracellular solute-binding protein, family 5 BHE96_05795 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BHE96_05800 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BHE96_05810 ENOG4108JQ7 (ABC) transporter BHE96_05825 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) BHE96_05830 ENOG4108ZCF integral membrane protein BHE96_05835 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis BHE96_05845 ENOG4105DPN Oligoendopeptidase f BHE96_05850 ENOG4105T58 Dithiol-disulfide isomerase BHE96_05855 ENOG4108Z18 K06886 hemoglobin BHE96_05860 ENOG4105E4C Lytic transglycosylase catalytic BHE96_05865 ENOG4105MIX Adenylate cyclase BHE96_05880 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BHE96_05885 ENOG4105EMS pseudouridine synthase BHE96_05890 ENOG4107S1Q Phosphatase BHE96_05905 ENOG4105ETU transcriptional activator (TenA BHE96_05910 ENOG4108VEU Thiamine monophosphate synthase BHE96_05930 ENOG4105D06 uba thif-type nad fad binding protein BHE96_05935 ENOG4105DWF phosphomethylpyrimidine kinase BHE96_05940 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH BHE96_05945 ENOG4107A88 BHE96_05995 ENOG4105ENA helicase BHE96_06015 ENOG4105CJ1 ABC, transporter BHE96_06030 ENOG4108ZMI UPF0477 protein BHE96_06040 ENOG4105C28 cystathionine BHE96_06045 ENOG4105C28 cystathionine BHE96_06065 ENOG4106BHF BHE96_06075 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase BHE96_06105 ENOG4105CKN UDP-glucose-hexose-1-phosphate uridylyltransferase BHE96_06110 ENOG4105CMR udp-glucose 4-epimerase BHE96_06115 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BHE96_06120 ENOG4105CK1 PTS System BHE96_06125 ENOG4105VCP PTS System BHE96_06155 ENOG4105KT7 mgtC SapB transporter BHE96_06180 ENOG4108IEG Formate dehydrogenase Alpha subunit BHE96_06190 ENOG4106A3M Cytochrome p-450 BHE96_06195 ENOG41087PP glycosyltransferase MGT family BHE96_06205 ENOG4105EXQ uroporphyrinogen iii synthase hem4 BHE96_06210 ENOG4105C4B ABC transporter, permease BHE96_06215 ENOG4108IXI (ABC) transporter BHE96_06225 ENOG4105Q95 Cupin 2, conserved barrel domain protein BHE96_06240 ENOG4105D2H Uronic isomerase BHE96_06245 ENOG4105CT4 transporter BHE96_06250 ENOG4107KJX Transcriptional regulator BHE96_06255 ENOG4107QZW Altronate oxidoreductase BHE96_06260 ENOG4105CTX dehydratase BHE96_06265 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BHE96_06270 ENOG4105F3H Histidine kinase BHE96_06290 ENOG4105BZU Histidine kinase BHE96_06295 ENOG4105WH1 Two component transcriptional regulator luxr family BHE96_06320 ENOG4107TSN permease BHE96_06335 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BHE96_06340 ENOG4105KWG Pfam:DUF1696 BHE96_06345 ENOG4105K7W phage-related replication protein BHE96_06350 ENOG410635T phage-like element pbsx protein BHE96_06390 ENOG4108TFU terminase (Small subunit) BHE96_06395 ENOG4105IG6 Phage terminase, large subunit BHE96_06400 ENOG4108MDF Phage Portal Protein BHE96_06425 ENOG41060SN BHE96_06440 ENOG4105PQS phage protein BHE96_06445 ENOG4105FR7 XkdM protein, phage-like element PBSX BHE96_06450 ENOG4105MTC XkdN-like protein BHE96_06455 ENOG4108FKH Transglycosylase SLT domain BHE96_06455 ENOG4108FKH Transglycosylase SLT domain BHE96_06455 ENOG4108FKH Transglycosylase SLT domain BHE96_06460 ENOG4108WZM domain protein BHE96_06465 ENOG4105X7F BHE96_06475 ENOG4105MFU Protein of unknown function (DUF2634) BHE96_06480 ENOG41066EA baseplate J family protein BHE96_06485 ENOG410906S phage-like element pbsx protein xkdt BHE96_06495 ENOG41068G1 BHE96_06525 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BHE96_06540 ENOG4105CJ3 phosphate transporter BHE96_06545 ENOG4107GRR phosphate transport regulator BHE96_06550 ENOG4107R7I amino acid BHE96_06560 ENOG4105EDW glycosyl transferase, family 39 BHE96_06565 ENOG4105CKK Glycosyl transferase, family 2 BHE96_06570 ENOG4105C0H protease BHE96_06580 ENOG4108ME1 Peptidase M55 D-aminopeptidase BHE96_06585 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BHE96_06590 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BHE96_06595 ENOG4105C3U ABC transporter BHE96_06605 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BHE96_06610 ENOG4105DTQ mandelate racemase muconate lactonizing BHE96_06615 ENOG4107SN7 NLP P60 protein BHE96_06620 ENOG4108JQ7 (ABC) transporter BHE96_06625 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BHE96_06630 ENOG4107TUM Amidinotransferase BHE96_06635 ENOG4108S4H thioesterase Superfamily protein BHE96_06640 ENOG4108428 Inherit from COG: -acetyltransferase BHE96_06650 ENOG41080TC multidrug resistance protein BHE96_06655 ENOG4105CIY formyltetrahydrofolate deformylase BHE96_06660 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BHE96_06675 ENOG4105K56 Transcriptional regulator BHE96_06680 ENOG4108ZHJ Organic hydroperoxide resistance protein BHE96_06695 ENOG4107TVC Glycosyl transferase, family 2 BHE96_06705 ENOG4105D8G Major Facilitator superfamily BHE96_06710 ENOG4108Y4K DNA-binding transcriptional activator BHE96_06715 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BHE96_06720 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BHE96_06730 ENOG4108W7F transporter, permease BHE96_06735 ENOG4108JJB ABC transporter BHE96_06740 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein BHE96_06745 ENOG4105VRS hydrolase family 18 BHE96_06760 ENOG4105CJW magnesium transporter BHE96_06765 ENOG4105V75 Transcriptional regulator BHE96_06785 ENOG4105DQE DNA ligase BHE96_06790 ENOG4105FDF Could be involved in DNA repair (By similarity) BHE96_06795 ENOG4107T5V SNARE associated Golgi BHE96_06800 ENOG4107TS3 membrane protein, TerC BHE96_06805 ENOG4108WZW RNA polymerase sigma BHE96_06815 ENOG410681C small acid-soluble spore protein BHE96_06825 ENOG4105D0M Protease HtpX homolog BHE96_06835 ENOG410900G Protein of unknown function (DUF421) BHE96_06840 ENOG4108TGC Acyltransferase BHE96_06845 ENOG4105BZU Histidine kinase BHE96_06850 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BHE96_06855 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) BHE96_06865 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BHE96_06875 ENOG4105DT1 RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate BHE96_06880 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) BHE96_06885 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) BHE96_06890 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) BHE96_06900 ENOG4105BZU Histidine kinase BHE96_06905 ENOG41090MY MarR family Transcriptional regulator BHE96_06910 ENOG4105ER2 Ompa motb domain protein BHE96_06915 ENOG4105E14 MotA TolQ exbB proton channel BHE96_06930 ENOG4108K88 Membrane BHE96_06940 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BHE96_06945 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase BHE96_06950 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BHE96_06955 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) BHE96_06965 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr BHE96_06990 ENOG4105F0V Cell wall hydrolase BHE96_07005 ENOG4105C59 p-type ATPase BHE96_07010 ENOG4105DC7 peptidase M24 BHE96_07020 ENOG4105CID antiterminator BHE96_07030 ENOG4105KRI phosphocarrier protein (HPr BHE96_07035 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BHE96_07045 ENOG4105F6S Spore photoproduct lyase BHE96_07050 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer BHE96_07055 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BHE96_07060 ENOG4105K4I Scp-like extracellular BHE96_07070 ENOG4105BZU Histidine kinase BHE96_07075 ENOG4105CHM Aminotransferase BHE96_07085 ENOG4107R88 Chemotaxis protein (CheV) BHE96_07090 ENOG4105UIN BHE96_07100 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein BHE96_07110 ENOG4105K6S Short-chain dehydrogenase reductase Sdr BHE96_07120 ENOG4105EPM Diguanylate phosphodiesterase BHE96_07125 ENOG4107IN1 Protein of unknown function (DUF1797) BHE96_07130 ENOG4108XRC Protein of unknown function (DUF458) BHE96_07160 ENOG4105NQC Flavodoxin BHE96_07180 ENOG4105D8X mechanosensitive ion channel BHE96_07185 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BHE96_07200 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BHE96_07205 ENOG4105D06 uba thif-type nad fad binding protein BHE96_07210 ENOG4105CVM Molybdenum cofactor synthesis domain protein BHE96_07215 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein BHE96_07220 ENOG4108ZAF Molybdopterin BHE96_07225 ENOG41067WU Molybdopterin converting factor (Subunit 1) BHE96_07235 ENOG4107X8C Efflux transporter RND family MFP subunit BHE96_07240 ENOG4105C19 ABC transporter BHE96_07245 ENOG4107RBB ABC transporter, permease BHE96_07250 ENOG4105E98 transcriptional regulator DeoR family BHE96_07255 ENOG4105DE4 1-phosphofructokinase BHE96_07260 ENOG4105DM4 PTS System BHE96_07275 ENOG4105C5H ABC transporter BHE96_07280 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BHE96_07305 ENOG4105BZU Histidine kinase BHE96_07315 ENOG4107ZYR domain protein BHE96_07320 ENOG4105CPN adenine deaminase BHE96_07325 ENOG4105CN5 Metallo-Beta-Lactamase BHE96_07330 ENOG4106148 UPF0356 protein BHE96_07340 ENOG4108X4Q Hydrolase BHE96_07345 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BHE96_07365 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BHE96_07370 ENOG4105C0W non-ribosomal peptide synthetase BHE96_07375 ENOG4107SQU synthase BHE96_07380 ENOG4105C0W non-ribosomal peptide synthetase BHE96_07385 ENOG4107SQU synthase BHE96_07390 ENOG4107SQU synthase BHE96_07395 ENOG4107SQU synthase BHE96_07400 ENOG4105C0W non-ribosomal peptide synthetase BHE96_07405 ENOG4105FQP Beta-lactamase BHE96_07415 ENOG4105CPP Dehydrogenase, E1 component BHE96_07420 ENOG4105C7S Dehydrogenase BHE96_07425 ENOG4107QN2 dihydrolipoyl dehydrogenase BHE96_07445 ENOG4105CXN decarboxylase BHE96_07450 ENOG4105WBI UPF0223 protein BHE96_07470 ENOG4105ECY inositol monophosphatase BHE96_07480 ENOG4105D4Y metalloprotease BHE96_07505 ENOG4105CI3 gtp-binding protein typa BHE96_07510 ENOG4105QA2 BHE96_07525 ENOG4108IAB Phoh family BHE96_07535 ENOG4105CSV Glutaminase BHE96_07695 ENOG41068G1 BHE96_07715 ENOG4105ZUG BHE96_07730 ENOG4107D0N BHE96_07785 ENOG4105CNI cell division protein FtsW BHE96_07790 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) BHE96_07800 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BHE96_07810 ENOG4105BZ9 Cytochrome C oxidase, subunit I BHE96_07815 ENOG4105CCU oxidase (Subunit III) BHE96_07820 ENOG41064X9 cytochrome C oxidase subunit IV BHE96_07835 ENOG41080XQ Signal transduction protein with cbs domains BHE96_07840 ENOG4106UY4 Inherit from COG: Scp-like extracellular BHE96_07865 ENOG4106H78 methyltransferase BHE96_07870 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BHE96_07875 ENOG4105H20 Sporulation integral membrane protein YlbJ BHE96_07880 ENOG4105D78 K07001 NTE family protein BHE96_07885 ENOG41063PX domain protein BHE96_07890 ENOG4105DQ6 Transposase BHE96_07900 ENOG4105CDE UPF0348 protein BHE96_07905 ENOG4105KNH Nucleic acid-binding protein BHE96_07910 ENOG41067VY 50S ribosomal protein L32 BHE96_07935 ENOG4108V6E Cell division protein mraZ BHE96_07940 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) BHE96_07950 ENOG4105CJN penicillin-binding protein BHE96_07955 ENOG4105CJN penicillin-binding protein BHE96_07960 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BHE96_07965 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BHE96_07970 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) BHE96_07975 ENOG4105CNI cell division protein FtsW BHE96_07980 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) BHE96_07985 ENOG4105D4A Cell wall formation (By similarity) BHE96_07990 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) BHE96_07995 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BHE96_08000 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BHE96_08010 ENOG4105FFI sigma-e processing peptidase spoiiga BHE96_08015 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BHE96_08025 ENOG4105DKW ABC transporter BHE96_08035 ENOG4105WR5 sporulation protein, YlmC YmxH family BHE96_08040 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BHE96_08045 ENOG4105DFA alanine racemase domain protein BHE96_08050 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) BHE96_08055 ENOG41067XK integral membrane protein BHE96_08060 ENOG4105DBK s4 domain protein BHE96_08075 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BHE96_08085 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BHE96_08090 ENOG4105C34 Pseudouridine synthase BHE96_08095 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) BHE96_08105 ENOG4105CXT aspartate transcarbamylase BHE96_08115 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BHE96_08120 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BHE96_08125 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) BHE96_08130 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) BHE96_08135 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) BHE96_08140 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) BHE96_08155 ENOG4107RIQ Sulfate adenylate transferase BHE96_08165 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) BHE96_08170 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein BHE96_08175 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein BHE96_08185 ENOG4105F23 Fibronectin-binding protein BHE96_08195 ENOG4105DSJ YicC domain protein BHE96_08200 ENOG4105KC4 UPF0296 protein BHE96_08205 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) BHE96_08215 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BHE96_08220 ENOG4105C25 Primosomal protein n' BHE96_08225 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) BHE96_08230 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) BHE96_08235 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BHE96_08240 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BHE96_08245 ENOG4108ZF3 Phosphatase BHE96_08250 ENOG4105D9P serine threonine protein kinase BHE96_08255 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) BHE96_08260 ENOG4105DJV ribulose-phosphate 3-epimerase BHE96_08265 ENOG4105FJ0 thiamine BHE96_08275 ENOG4105VB9 50S ribosomal protein l28 BHE96_08280 ENOG4108ZAA Alkaline-shock protein BHE96_08285 ENOG4105DP4 dak2 domain fusion protein ylov BHE96_08295 ENOG4105EJQ L-serine dehydratase BHE96_08300 ENOG4105CB5 ATP-dependent DNA helicase recG BHE96_08305 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) BHE96_08310 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) BHE96_08315 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BHE96_08320 ENOG4105CHR reductase BHE96_08325 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BHE96_08330 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BHE96_08335 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) BHE96_08340 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BHE96_08350 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) BHE96_08360 ENOG4105K5M 30s ribosomal protein S16 BHE96_08365 ENOG4108BW8 UPF0109 protein BHE96_08380 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) BHE96_08385 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BHE96_08390 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) BHE96_08395 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BHE96_08405 ENOG4105VM1 flagellar BHE96_08410 ENOG4105CMV Succinyl-CoA synthetase subunit beta BHE96_08415 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BHE96_08420 ENOG4105C79 DNA protecting protein DprA BHE96_08425 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BHE96_08430 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) BHE96_08435 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BHE96_08440 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BHE96_08445 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) BHE96_08455 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BHE96_08460 ENOG4108ZC9 flagellar basal-body rod protein flgc BHE96_08465 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BHE96_08470 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BHE96_08475 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BHE96_08490 ENOG4106YF4 Flagellar biosynthesis chaperone BHE96_08500 ENOG410696Y Flagellar hook-length control protein BHE96_08505 ENOG410822I Flagellar hook capping protein BHE96_08510 ENOG4108JQA flagellar BHE96_08515 ENOG41068WV flagellar FlbD family protein BHE96_08525 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BHE96_08530 ENOG4105DD5 Flagellar motor switch protein BHE96_08535 ENOG4107YTP response regulator receiver protein BHE96_08545 ENOG4105CN7 Flagellar biosynthetic protein FliP BHE96_08550 ENOG4105VS8 Flagellar biosynthetic protein fliq BHE96_08555 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BHE96_08560 ENOG4105D00 flagellar biosynthetic protein flhB BHE96_08565 ENOG4105D7B Flagellar biosynthesis protein flha BHE96_08570 ENOG4105FZW flagellar biosynthesis regulator FlhF BHE96_08580 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BHE96_08585 ENOG4105CBS Chea signal transduction histidine kinase BHE96_08590 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis BHE96_08600 ENOG4108Z4W Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity) BHE96_08605 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BHE96_08615 ENOG4105CE9 30S ribosomal protein S2 BHE96_08625 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) BHE96_08630 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BHE96_08635 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) BHE96_08640 ENOG4105KNE Phosphatidate cytidylyltransferase BHE96_08650 ENOG4105DZP Membrane-associated zinc metalloprotease BHE96_08655 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BHE96_08660 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) BHE96_08665 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BHE96_08670 ENOG4105CHV Transcription elongation factor NusA BHE96_08675 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination BHE96_08680 ENOG4105VHM ribosomal protein BHE96_08685 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BHE96_08690 ENOG4105W7A Protein of unknown function (DUF503) BHE96_08695 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) BHE96_08700 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BHE96_08705 ENOG4105DTN riboflavin biosynthesis protein ribF BHE96_08710 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BHE96_08715 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) BHE96_08725 ENOG4105C1V Peptidase, M16 BHE96_08735 ENOG4105E35 Dipicolinate synthase subunit A BHE96_08740 ENOG4108S0H Dipicolinic acid synthetase, b subunit BHE96_08745 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BHE96_08755 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BHE96_08765 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit BHE96_08775 ENOG4105CNU cell division protein FtsK BHE96_08780 ENOG4105FDP GntR family transcriptional regulator BHE96_08795 ENOG4105EYF MMPL domain protein BHE96_08810 ENOG4108RKS Short-chain dehydrogenase reductase Sdr BHE96_08815 ENOG4105XZV Protein of unknown function (DUF3243) BHE96_08830 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase BHE96_08835 ENOG4105CEV competence damage-inducible protein BHE96_08840 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BHE96_08845 ENOG4108A04 Beta-lactamase BHE96_08855 ENOG4105D48 metallophosphoesterase BHE96_08860 ENOG4105MCT stage V sporulation protein S BHE96_08865 ENOG4105CPQ Dehydrogenase BHE96_08870 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BHE96_08875 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BHE96_08895 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) BHE96_08910 ENOG4108151 Beta-lactamase domain protein BHE96_08915 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BHE96_08920 ENOG4108JA1 polyketide synthase BHE96_08925 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BHE96_08930 ENOG41062T2 Acyl carrier protein BHE96_08935 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase BHE96_08940 ENOG4108MGH Enoyl-CoA hydratase BHE96_08945 ENOG4108KQ6 Enoyl-CoA hydratase BHE96_08950 ENOG4105C0W non-ribosomal peptide synthetase BHE96_08955 ENOG4107SQU synthase BHE96_08965 ENOG4105C0W non-ribosomal peptide synthetase BHE96_08975 ENOG4106A3M Cytochrome p-450 BHE96_08980 ENOG4105WFK nuclease BHE96_08985 ENOG4105XPP Protein of unknown function (DUF1275) BHE96_08995 ENOG4105DQ6 Transposase BHE96_09005 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin BHE96_09015 ENOG4105K7W phage-related replication protein BHE96_09020 ENOG4108X3M OsmC Ohr family protein BHE96_09045 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BHE96_09070 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BHE96_09075 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BHE96_09080 ENOG4105U6W MutT NUDIX family protein BHE96_09085 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BHE96_09095 ENOG4106F1P AAA ATPase, central domain protein BHE96_09100 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BHE96_09105 ENOG4105CXI aluminum resistance protein BHE96_09110 ENOG4105KV4 Transcriptional regulator BHE96_09115 ENOG4105C5F glutamine synthetase BHE96_09125 ENOG4105CT4 transporter BHE96_09130 ENOG4105DSG hydrolase family 43 BHE96_09140 ENOG4105C93 Xylose Isomerase BHE96_09145 ENOG4105CMG Carbohydrate kinase BHE96_09150 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BHE96_09185 ENOG4105DQ4 alcohol dehydrogenase BHE96_09195 ENOG4105EPI acetyltransferase, (GNAT) family BHE96_09235 ENOG4108M1A Chitin-binding protein BHE96_09255 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BHE96_09260 ENOG4105K7W phage-related replication protein BHE96_09280 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BHE96_09290 ENOG4108SVB resolvase BHE96_09295 ENOG4105VPS UPF0291 protein BHE96_09300 ENOG4105CV1 Transketolase (EC 2.2.1.1) BHE96_09310 ENOG4105VXM UPF0154 protein BHE96_09320 ENOG4107QIV Cytochrome c biogenesis protein BHE96_09355 ENOG4108I0Z Aconitate hydratase BHE96_09360 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BHE96_09375 ENOG41067CD Small, acid-soluble spore protein Tlp BHE96_09385 ENOG4105MI2 BHE96_09390 ENOG4105W8X HesB YadR YfhF-family protein BHE96_09395 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BHE96_09400 ENOG4105K4P CoA-binding domain protein BHE96_09405 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BHE96_09430 ENOG4105CPQ Dehydrogenase BHE96_09435 ENOG4108UHU Aldolase BHE96_09440 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) BHE96_09445 ENOG4105DMW Dehydrogenase reductase BHE96_09455 ENOG4108I5G Major Facilitator superfamily BHE96_09470 ENOG4105FVX BHE96_09480 ENOG4107R39 (ABC) transporter BHE96_09515 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BHE96_09525 ENOG4107SYN Glycosyl hydrolases family 43 BHE96_09550 ENOG4105DTD Dehydrogenase BHE96_09555 ENOG4108IIH CoA-transferase subunit B BHE96_09560 ENOG4105D6N CoA-transferase, subunit a BHE96_09565 ENOG4105CY2 Citrate transporter BHE96_09570 ENOG4106A3M Cytochrome p-450 BHE96_09575 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BHE96_09580 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BHE96_09585 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BHE96_09590 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BHE96_09595 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) BHE96_09610 ENOG4107T5V SNARE associated Golgi BHE96_09615 ENOG4107QX3 carboxylase BHE96_09620 ENOG4105E39 Enoyl-CoA hydratase BHE96_09625 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase BHE96_09630 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit BHE96_09635 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BHE96_09640 ENOG4105CEY Amp-dependent synthetase and ligase BHE96_09645 ENOG4105C1G acyl-Coa dehydrogenase BHE96_09650 ENOG4105F32 YngK protein BHE96_09655 ENOG4106U2H Protein of unknown function (DUF1360) BHE96_09665 ENOG4105CEY Amp-dependent synthetase and ligase BHE96_09670 ENOG4105C0W non-ribosomal peptide synthetase BHE96_09680 ENOG4105C0W non-ribosomal peptide synthetase BHE96_09690 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family BHE96_09695 ENOG4108N2V aldose 1-epimerase BHE96_09700 ENOG4107QJQ Mate efflux family protein BHE96_09725 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BHE96_09730 ENOG4108RWP Major Facilitator Superfamily protein BHE96_09735 ENOG4105WAB arsR family transcriptional regulator BHE96_09740 ENOG4105C22 threonyL-tRNA synthetase BHE96_09750 ENOG4108KSA LysR family transcriptional regulator BHE96_09755 ENOG4105CB2 alcohol dehydrogenase BHE96_09760 ENOG4105BZ8 glutamate synthase BHE96_09765 ENOG4105CBC glutamate synthase BHE96_09770 ENOG4105C5Q Transcriptional regulator BHE96_09775 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BHE96_09805 ENOG4108UB7 BHE96_09815 ENOG4107U6E carbohydrate kinase FGGY BHE96_09820 ENOG4108M3J Dehydrogenase BHE96_09825 ENOG4108J2R molybdopterin oxidoreductase BHE96_09850 ENOG4106ANW SMI1_KNR4 BHE96_09860 ENOG4108Z7R Chaperone CsaA BHE96_09865 ENOG4105FTV AraC Family Transcriptional Regulator BHE96_09875 ENOG4108W8B Beta-lactamase domain protein BHE96_09885 ENOG4105KTU Transcriptional regulator, arsr family BHE96_09895 ENOG4108SJC Membrane BHE96_09920 ENOG41069ER domain protein BHE96_09925 ENOG4105C9U ATP-dependent DNA helicase RecQ BHE96_09935 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BHE96_09940 ENOG4105SCY DNAK suppressor BHE96_09985 ENOG4105C26 Dehydrogenase BHE96_09990 ENOG4105EWU Squalene--hopene cyclase BHE96_09995 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BHE96_10000 ENOG4105C8J )-transporter BHE96_10005 ENOG4105C09 Bile acid BHE96_10015 ENOG4105C7S Dehydrogenase BHE96_10020 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BHE96_10025 ENOG4107T89 von Willebrand factor, type A BHE96_10030 ENOG4105GMT ATPase associated with various cellular activities aaa_5 BHE96_10040 ENOG4105K4H Nlp p60 protein BHE96_10045 ENOG41087PP glycosyltransferase MGT family BHE96_10055 ENOG4107QMU Mate efflux family protein BHE96_10060 ENOG4106SCS STAS domain BHE96_10080 ENOG4105FR1 rard protein BHE96_10095 ENOG41090U3 tautomerase BHE96_10115 ENOG4105FBA Phospholipase Carboxylesterase BHE96_10130 ENOG4105E1V na solute symporter BHE96_10140 ENOG4105CS2 ec 3.2.1.21 BHE96_10145 ENOG4108S3Y transcriptional regulator BHE96_10165 ENOG4108VXD carboxy-peptidase BHE96_10170 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BHE96_10175 ENOG4106Z5R BHE96_10180 ENOG410841Q phosphoesterase PA-phosphatase related protein BHE96_10210 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BHE96_10215 ENOG4108TSC N-acetyltransferase BHE96_10220 ENOG4107S4Y M20 DapE family protein YgeY BHE96_10235 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) BHE96_10325 ENOG4105C26 Dehydrogenase BHE96_10340 ENOG4106ANW SMI1_KNR4 BHE96_10345 ENOG4106BHF BHE96_10355 ENOG4107Y9E nuclease BHE96_10370 ENOG4105E0X reductase BHE96_10375 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) BHE96_10385 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) BHE96_10390 ENOG41090WU lipolytic protein G-D-S-L family BHE96_10395 ENOG4108KF3 Electron transport protein SCO1 SenC BHE96_10405 ENOG4105C7B Threonine dehydratase BHE96_10415 ENOG4108UT2 hemolysin iii BHE96_10425 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BHE96_10430 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BHE96_10440 ENOG4107YX5 Pfam:DUF548 BHE96_10445 ENOG4108Y6J UPF0403 protein BHE96_10450 ENOG4105C01 Dihydroxy-acid dehydratase BHE96_10465 ENOG4108V06 Glutathione peroxidase BHE96_10470 ENOG4105CVG Homoserine O-transsuccinylase BHE96_10510 ENOG41081VK Ribonuclease BHE96_10530 ENOG410890F Dynamin family BHE96_10540 ENOG41065KQ synthase BHE96_10560 ENOG410900G Protein of unknown function (DUF421) BHE96_10580 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) BHE96_10655 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BHE96_10660 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BHE96_10685 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BHE96_10690 ENOG4106ITI Glutaredoxin BHE96_10730 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BHE96_10815 ENOG4106210 phosphatase activity BHE96_10835 ENOG4106J9J DNA polymerase BHE96_10845 ENOG4106IVX BHE96_10850 ENOG4106PTB DnaB-like helicase C terminal domain BHE96_10860 ENOG41088HM BHE96_10865 ENOG4106YR8 BHE96_10895 ENOG4105K7W phage-related replication protein BHE96_10915 ENOG4108RAV Conserved protein BHE96_10920 ENOG4108J9Q DNA ligase BHE96_10965 ENOG4105GJD protein, conserved in bacteria BHE96_11085 ENOG4107D0N BHE96_11150 ENOG4107NTZ BHE96_11185 ENOG4108NE4 BHE96_11225 ENOG4105ZUG BHE96_11235 ENOG4105ZUG BHE96_11240 ENOG4105K70 DNA-binding protein BHE96_11340 ENOG41068G1 BHE96_11390 ENOG4105E4C Lytic transglycosylase catalytic BHE96_11415 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase BHE96_11445 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BHE96_11455 ENOG4108YTE sporulation protein YunB BHE96_11475 ENOG4106BHF BHE96_11490 ENOG4107Y9E nuclease BHE96_11505 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) BHE96_11510 ENOG4105CTD carboxy-peptidase BHE96_11515 ENOG4105DVT helicase BHE96_11530 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BHE96_11540 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) BHE96_11545 ENOG4108UKS UPF0398 protein BHE96_11555 ENOG4107X2U Inherit from COG: Exonuclease-like protein BHE96_11560 ENOG4108I5C dEAD DEAH box helicase BHE96_11605 ENOG4108UI2 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) BHE96_11610 ENOG4105BZ4 penicillin-binding protein BHE96_11620 ENOG4105CSM endonuclease III BHE96_11630 ENOG4105C5S asparaginyl-tRNA synthetase BHE96_11635 ENOG4105CHM Aminotransferase BHE96_11645 ENOG4105YAC BHE96_11650 ENOG4105DVT helicase BHE96_11655 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BHE96_11665 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BHE96_11675 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BHE96_11680 ENOG4105CPK Glycosyl transferase (Group 1 BHE96_11685 ENOG4105FJR Lmbe family BHE96_11690 ENOG4108Z5K methylglyoxal synthase BHE96_11695 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) BHE96_11700 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase BHE96_11705 ENOG4108JYZ YitT family BHE96_11710 ENOG4105F0F Oxalate decarboxylase BHE96_11730 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) BHE96_11750 ENOG41068YB TPR repeat-containing protein BHE96_11755 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BHE96_11765 ENOG4105CIH Imidazole acetol-phosphate transaminase BHE96_11775 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BHE96_11780 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase BHE96_11785 ENOG4105DK0 Indole-3-glycerol phosphate synthase BHE96_11795 ENOG4105CRQ synthase (Component I) BHE96_11800 ENOG4105KHN chorismate mutase BHE96_11810 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BHE96_11815 ENOG4105BZU Histidine kinase BHE96_11820 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) BHE96_11825 ENOG4105EAH synthase BHE96_11830 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BHE96_11835 ENOG4105XXQ heptaprenyl diphosphate synthase component I BHE96_11840 ENOG4105WP2 Tryptophan RNA-binding attenuator protein BHE96_11845 ENOG4105EUJ GTP cyclohydrolase i BHE96_11850 ENOG4105K70 DNA-binding protein BHE96_11855 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) BHE96_11870 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BHE96_11875 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BHE96_11895 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BHE96_11900 ENOG4105CAT Cytidine monophosphate kinase BHE96_11910 ENOG4105MSI germination protein ypeb BHE96_11920 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) BHE96_11925 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase BHE96_11940 ENOG4107RGJ metallophosphoesterase BHE96_11955 ENOG4105I7S Abortive infection protein BHE96_11960 ENOG4105C9U ATP-dependent DNA helicase RecQ BHE96_11965 ENOG4105T7X BHE96_11975 ENOG4108SAX Membrane BHE96_11980 ENOG4108JQ1 Dehydrogenase BHE96_11995 ENOG4105BZU Histidine kinase BHE96_12000 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BHE96_12005 ENOG4105CRE cytochrome C BHE96_12010 ENOG4107TWT Cytochrome c biogenesis protein BHE96_12020 ENOG4105FE9 pseudouridine synthase BHE96_12030 ENOG4108JIC nucleoside recognition domain protein BHE96_12035 ENOG4105DZ1 carboxypeptidase BHE96_12045 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) BHE96_12050 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) BHE96_12075 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BHE96_12080 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BHE96_12085 ENOG4108R6K riboflavin synthase, subunit alpha BHE96_12110 ENOG4107ZE5 PPIases accelerate the folding of proteins BHE96_12115 ENOG4105PTM secreted protein BHE96_12120 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) BHE96_12130 ENOG4105G6R Stage v sporulation protein ae BHE96_12140 ENOG4105CZ3 stage V sporulation protein ad BHE96_12145 ENOG41090VF Stage v sporulation protein ac BHE96_12160 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BHE96_12165 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) BHE96_12170 ENOG41082AN stage II sporulation protein BHE96_12175 ENOG4105DZ1 carboxypeptidase BHE96_12180 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) BHE96_12185 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) BHE96_12190 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BHE96_12200 ENOG4105I3K Ferric uptake regulator, Fur family BHE96_12205 ENOG4105MZ9 stage II sporulation protein m BHE96_12225 ENOG4105DFD Na H antiporter BHE96_12230 ENOG4108IJ0 Aspartate ammonia-lyase BHE96_12235 ENOG4105HDK L-asparaginase BHE96_12240 ENOG4108IMY Transcriptional regulator BHE96_12250 ENOG4108YZ4 nudix hydrolase BHE96_12260 ENOG4105CPC Aldo Keto reductase BHE96_12280 ENOG4106HZJ BHE96_12285 ENOG4105RHY Pfam:UPF0157 BHE96_12290 ENOG4105KAC Antibiotic biosynthesis monooxygenase BHE96_12295 ENOG4108XET gCN5-related N-acetyltransferase BHE96_12300 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BHE96_12315 ENOG4105C02 permease BHE96_12320 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase BHE96_12325 ENOG4105CS9 pantothenic acid kinase BHE96_12335 ENOG4108IXY short-chain dehydrogenase reductase BHE96_12340 ENOG41069FQ Metallo-beta-lactamase superfamily BHE96_12345 ENOG4105II7 pyrroline-5-carboxylate reductase BHE96_12350 ENOG4108KQ6 Enoyl-CoA hydratase BHE96_12355 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase BHE96_12360 ENOG4106A3M Cytochrome p-450 BHE96_12375 ENOG4105C0W non-ribosomal peptide synthetase BHE96_12380 ENOG4105C0W non-ribosomal peptide synthetase BHE96_12390 ENOG4105C0W non-ribosomal peptide synthetase BHE96_12400 ENOG4105CHR reductase BHE96_12405 ENOG4105CEY Amp-dependent synthetase and ligase BHE96_12420 ENOG4107QKG PfaD family BHE96_12430 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BHE96_12440 ENOG4108K70 Transcriptional regulator BHE96_12450 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BHE96_12460 ENOG410861F 50S ribosomal protein L33 BHE96_12465 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) BHE96_12470 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BHE96_12475 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BHE96_12480 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BHE96_12490 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) BHE96_12495 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BHE96_12500 ENOG4108HNZ carboxyl transferase BHE96_12505 ENOG4108ZVT methylmalonyl-coA epimerase BHE96_12510 ENOG4108VZI ErfK ybiS ycfS ynhG family protein BHE96_12515 ENOG4108QEG Membrane BHE96_12520 ENOG4105CDA abc transporter atp-binding protein BHE96_12525 ENOG4105E5Q amino acid AbC transporter BHE96_12530 ENOG4108HW3 (ABC) transporter BHE96_12535 ENOG4108Y6J UPF0403 protein BHE96_12540 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) BHE96_12545 ENOG4105C7S Dehydrogenase BHE96_12550 ENOG4105CPP Dehydrogenase, E1 component BHE96_12565 ENOG4105CKM Branched-chain carboxylic acid kinase BHE96_12570 ENOG4107RDP Dehydrogenase BHE96_12580 ENOG4108JUB Transcriptional regulator BHE96_12585 ENOG4106CCJ Protein of unknown function (DUF2627) BHE96_12590 ENOG4105CR4 methylisocitrate lyase BHE96_12595 ENOG4105DXD 2-methylcitrate dehydratase BHE96_12605 ENOG4105C1G acyl-Coa dehydrogenase BHE96_12610 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BHE96_12620 ENOG4108QXE glycerophosphoryl diester phosphodiesterase BHE96_12625 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BHE96_12650 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BHE96_12665 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BHE96_12670 ENOG4107QQR Sporulation BHE96_12675 ENOG4105S1Z Stage IV sporulation protein B BHE96_12680 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BHE96_12685 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BHE96_12690 ENOG4105DX0 Hemolysin A BHE96_12695 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BHE96_12705 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BHE96_12725 ENOG4108ZSR alkaline shock protein BHE96_12750 ENOG410644B Stage III sporulation protein af BHE96_12760 ENOG4105KQ4 Stage iii sporulation protein ad BHE96_12765 ENOG4108CQH stage III sporulation protein AC BHE96_12770 ENOG4105KR5 Stage iii sporulation protein BHE96_12775 ENOG4105CD2 stage iii sporulation protein aa BHE96_12785 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BHE96_12790 ENOG4105DC7 peptidase M24 BHE96_12800 ENOG4105CBJ Metal-dependent enzyme BHE96_12820 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) BHE96_12825 ENOG4105WZW rhodanese family BHE96_12830 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor BHE96_12840 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BHE96_12845 ENOG4105C0D helicase BHE96_12860 ENOG4108IMY Transcriptional regulator BHE96_12870 ENOG4105VFR signal peptidase BHE96_12930 ENOG4105C37 (CBS) domain BHE96_12955 ENOG4105C5X domain protein BHE96_12995 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BHE96_13000 ENOG4105WDJ 50S ribosomal protein L33 BHE96_13010 ENOG41068DG YceG-like family BHE96_13015 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BHE96_13020 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BHE96_13025 ENOG4105E2Z phosphate ABC transporter (Permease BHE96_13030 ENOG4105C8U phosphate abc transporter BHE96_13035 ENOG4105CVA phosphate BHE96_13040 ENOG4107RF6 penicillin-binding protein BHE96_13050 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BHE96_13055 ENOG4105SXS Protein of unknown function (DUF456) BHE96_13070 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BHE96_13075 ENOG41063Y9 BHE96_13080 ENOG4108U5J '-nucleotidase BHE96_13085 ENOG4105N80 Ferric uptake regulator, Fur family BHE96_13090 ENOG4108JYZ YitT family BHE96_13095 ENOG41069ZM Protein of unknown function (DUF2624) BHE96_13100 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BHE96_13115 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BHE96_13120 ENOG4105EGD dinuclear metal center protein, YbgI family BHE96_13135 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BHE96_13140 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BHE96_13145 ENOG4108UPT UPF0178 protein BHE96_13150 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BHE96_13160 ENOG4105C38 Glycyl-tRNA synthetase beta subunit BHE96_13165 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit BHE96_13170 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) BHE96_13180 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BHE96_13185 ENOG4105KG3 cytidine deaminase BHE96_13190 ENOG4107YR5 Diacylglycerol kinase BHE96_13195 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BHE96_13200 ENOG4105CTJ Metal Dependent Phosphohydrolase BHE96_13205 ENOG4105C9A Phoh family BHE96_13210 ENOG4105EI1 sporulation protein yqfd BHE96_13215 ENOG41068P3 sporulation protein YqfC BHE96_13225 ENOG4105DI5 UPF0365 protein BHE96_13230 ENOG4105F7J membrane-bound serine protease BHE96_13235 ENOG4105KTH gatB Yqey BHE96_13250 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BHE96_13255 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BHE96_13260 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) BHE96_13265 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BHE96_13270 ENOG4105CFG Acts as a chaperone (By similarity) BHE96_13275 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ BHE96_13280 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) BHE96_13285 ENOG4105CSA Coproporphyrinogen iii oxidase BHE96_13290 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BHE96_13300 ENOG4108ZRV stage ii sporulation protein p BHE96_13305 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) BHE96_13310 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) BHE96_13315 ENOG4105TQK DNA polymerase iii, delta' subunit BHE96_13325 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 BHE96_13330 ENOG4108UK2 deaminase BHE96_13335 ENOG4105KQC Competence protein BHE96_13345 ENOG4108D32 Methyltransferase BHE96_13355 ENOG4108WF2 Metal Dependent Phosphohydrolase BHE96_13360 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) BHE96_13365 ENOG410812S Rna-binding protein BHE96_13370 ENOG4105E2X shikimate dehydrogenase BHE96_13375 ENOG4105CQW ribosome biogenesis GTPase YqeH BHE96_13380 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase BHE96_13400 ENOG41080BT SNARE associated Golgi BHE96_13415 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BHE96_13440 ENOG41086D8 Transcriptional regulator BHE96_13450 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BHE96_13465 ENOG4108U7W acetyltransferase BHE96_13480 ENOG4105DQF Hydrolase BHE96_13485 ENOG4108HCJ Hydrolase BHE96_13495 ENOG4105DG6 mannose-6-phosphate isomerase BHE96_13500 ENOG4105DM4 PTS System BHE96_13515 ENOG4108Z66 YbaK ebsC protein BHE96_13520 ENOG4107RSM transcriptional regulator BHE96_13525 ENOG4105D94 Major Facilitator Superfamily BHE96_13530 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BHE96_13535 ENOG41082JN Transcriptional regulator BHE96_13555 ENOG4105TMB Formate nitrite transporter BHE96_13560 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) BHE96_13565 ENOG4108JB9 formate dehydrogenase BHE96_13580 ENOG4105C28 cystathionine BHE96_13610 ENOG4107XRG penicillin-binding protein BHE96_13615 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BHE96_13625 ENOG4105CFP Peptidase U32 BHE96_13630 ENOG4105XYU peptidase (U32 family) BHE96_13635 ENOG4108VQJ O-methyltransferase BHE96_13640 ENOG4105HHA aminodeoxychorismate lyase BHE96_13650 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) BHE96_13655 ENOG4105VBH UPF0297 protein BHE96_13660 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BHE96_13665 ENOG4105C02 permease BHE96_13670 ENOG4105CDA abc transporter atp-binding protein BHE96_13675 ENOG4105CT1 (ABC) transporter BHE96_13680 ENOG4105EAD ABC transporter BHE96_13685 ENOG4105DRP amino acid AbC transporter BHE96_13695 ENOG41060CR BHE96_13705 ENOG4105C7H Helicase, RecD TraA family BHE96_13715 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BHE96_13720 ENOG4105C3J Cysteine desulfurase BHE96_13730 ENOG4105D1H recombination factor protein RarA BHE96_13740 ENOG4105DQ6 Transposase BHE96_13745 ENOG4105CUZ uba thif-type nad fad binding protein BHE96_13755 ENOG4105C9M aspartyl-trna synthetase BHE96_13760 ENOG4105CUT histidyl-tRNA synthetase BHE96_13765 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BHE96_13770 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) BHE96_13775 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BHE96_13785 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BHE96_13790 ENOG41067VP Protein of unknown function (DUF1049) BHE96_13795 ENOG4105NCW Trka-c domain protein BHE96_13800 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BHE96_13810 ENOG4105CKP Polysaccharide Biosynthesis Protein BHE96_13815 ENOG4108QG2 Membrane BHE96_13820 ENOG4105NAP BHE96_13825 ENOG4105VIE preprotein translocase, subunit YajC BHE96_13830 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BHE96_13835 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BHE96_13840 ENOG41061AI Protein of unknown function (DUF2905) BHE96_13845 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) BHE96_13850 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BHE96_13870 ENOG4106678 morphogenetic protein associated with SpoVID BHE96_13875 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BHE96_13880 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BHE96_13885 ENOG4108IYU L-aspartate oxidase BHE96_13900 ENOG4105CQC Prephenate dehydratase BHE96_13910 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BHE96_13920 ENOG4105K46 50S ribosomal protein l27 BHE96_13925 ENOG4105X36 (ribosomal) protein BHE96_13930 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BHE96_13945 ENOG4107QMS site-determining protein BHE96_13950 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BHE96_13955 ENOG4105YHC Rod shape-determining protein MreD BHE96_13960 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BHE96_13965 ENOG4105DFF Rod shape-determining protein mreb BHE96_13970 ENOG4105W5Q DNA repair protein (RadC BHE96_13975 ENOG4108Z03 MAF-like protein BHE96_13985 ENOG4106A3R peptidase BHE96_13990 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BHE96_13995 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) BHE96_14005 ENOG4106AR7 Spore coat protein BHE96_14010 ENOG41068KH stage VI sporulation protein D BHE96_14015 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase BHE96_14020 ENOG4105D52 delta-aminolevulinic acid dehydratase BHE96_14030 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BHE96_14040 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BHE96_14050 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BHE96_14055 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BHE96_14060 ENOG4108IUQ atp-dependent protease BHE96_14065 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) BHE96_14070 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BHE96_14080 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BHE96_14085 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BHE96_14090 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) BHE96_14100 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BHE96_14105 ENOG4108ZP8 Acetolactate synthase small subunit BHE96_14110 ENOG4105C7K acetolactate synthase BHE96_14155 ENOG4105M59 Phosphodiesterase, mj0936 family BHE96_14160 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BHE96_14165 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BHE96_14170 ENOG4108XJQ germination protein BHE96_14175 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) BHE96_14180 ENOG41067TZ transcriptional regulator, MarR family BHE96_14185 ENOG4105PFC Transcriptional regulator BHE96_14195 ENOG4105E33 succinate dehydrogenase BHE96_14205 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit BHE96_14215 ENOG4105CFH Aspartokinase BHE96_14225 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BHE96_14230 ENOG4105K63 Thioredoxin BHE96_14235 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) BHE96_14240 ENOG4105C10 Electron transfer flavoprotein BHE96_14245 ENOG4105BZJ Electron transfer flavoprotein BHE96_14250 ENOG41060WC Enoyl-CoA hydratase BHE96_14255 ENOG4107Z3H Transcriptional regulator, TetR family BHE96_14260 ENOG4105CEY Amp-dependent synthetase and ligase BHE96_14265 ENOG4108YV3 Protein of unknown function (DUF2711) BHE96_14275 ENOG4105C98 muts2 protein BHE96_14280 ENOG4105DCG PHP domain protein BHE96_14295 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BHE96_14300 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BHE96_14305 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BHE96_14310 ENOG4108RWN rrna methyltransferase BHE96_14315 ENOG41067MF small acid-soluble spore protein BHE96_14325 ENOG4105CQB FAD linked oxidase domain protein BHE96_14330 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BHE96_14340 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) BHE96_14345 ENOG4105DRS transport system, permease BHE96_14360 ENOG4108MDK Dehydrogenase BHE96_14370 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase BHE96_14375 ENOG4105EF1 ribulokinase BHE96_14385 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase BHE96_14390 ENOG4105CN9 Peptidase m42 family protein BHE96_14400 ENOG410696E Membrane BHE96_14405 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) BHE96_14410 ENOG4105VJV 50s ribosomal protein L35 BHE96_14415 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BHE96_14420 ENOG41067MG lrgb family BHE96_14430 ENOG4105DY9 regulatoR BHE96_14435 ENOG4108HRK Histidine kinase BHE96_14445 ENOG4105U0R haloacid dehalogenase-like hydrolase BHE96_14450 ENOG4105C22 threonyL-tRNA synthetase BHE96_14455 ENOG4108TDW sporulation protein YtxC BHE96_14480 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) BHE96_14485 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BHE96_14490 ENOG4105KVH Transcriptional regulator BHE96_14495 ENOG4105F27 Major Facilitator BHE96_14500 ENOG4105CV8 reductase BHE96_14505 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BHE96_14515 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BHE96_14520 ENOG4105C2M dna polymerase I BHE96_14525 ENOG4105BZU Histidine kinase BHE96_14530 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BHE96_14540 ENOG4108HMX isocitrate dehydrogenase (NADP) BHE96_14545 ENOG4105BZN citrate synthase BHE96_14550 ENOG410780I phosphoprotein phosphatase activity BHE96_14570 ENOG4105G7B Protein of unknown function (DUF2992) BHE96_14575 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase BHE96_14585 ENOG4108REF Sporulation integral membrane protein ytvi BHE96_14590 ENOG4105FS0 cytoplasmic membrane protein BHE96_14595 ENOG4105CA9 Pyruvate kinase BHE96_14600 ENOG4105CTQ phosphohexokinase BHE96_14605 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BHE96_14610 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) BHE96_14615 ENOG4105C6K Malic enzyme BHE96_14620 ENOG4105C0B DNA polymerase III (alpha subunit) BHE96_14625 ENOG4105VV2 BHE96_14635 ENOG4106EVM BHE96_14640 ENOG4105SFS phosphoesterase RecJ domain protein BHE96_14655 ENOG4105E8R UPF0173 metal-dependent hydrolase BHE96_14665 ENOG4105CH7 arginosuccinase BHE96_14670 ENOG4105CDH Citrulline--aspartate ligase BHE96_14675 ENOG4105EPU Molybdenum cofactor synthesis domain protein BHE96_14685 ENOG4105DQ6 Transposase BHE96_14690 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BHE96_14700 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BHE96_14705 ENOG4105KBJ sporulation protein ytfj BHE96_14715 ENOG4105VK3 rdd domain containing protein BHE96_14720 ENOG4105D07 Signal peptide peptidase, SppA BHE96_14725 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) BHE96_14730 ENOG4105EFZ amidohydrolase BHE96_14735 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BHE96_14745 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) BHE96_14770 ENOG4105U5Y Transcriptional regulator BHE96_14780 ENOG4105BZU Histidine kinase BHE96_14790 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BHE96_14795 ENOG4105C26 Dehydrogenase BHE96_14845 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BHE96_14855 ENOG4108Z0Z intracellular protease Pfpi family BHE96_14875 ENOG4108NGU Transcriptional regulator BHE96_14890 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BHE96_14905 ENOG4105F1V Acetoin utilization protein BHE96_14910 ENOG4105W87 Cbs domain BHE96_14915 ENOG4105DGU Histone deacetylase BHE96_14920 ENOG4105ER2 Ompa motb domain protein BHE96_14925 ENOG4107R0U MotA TolQ exbB proton channel BHE96_14930 ENOG4105ETE Transcriptional regulator (LacI family BHE96_14935 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BHE96_14955 ENOG4105DFU Cell wall formation (By similarity) BHE96_14965 ENOG4108VDD TRNA binding domain protein BHE96_14980 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ BHE96_14995 ENOG4105C6K Malic enzyme BHE96_15000 ENOG4105C8F Beta-lactamase domain protein BHE96_15005 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) BHE96_15015 ENOG4108V15 phosphotransferase enzyme family BHE96_15030 ENOG4107F58 2'-5' rna ligase BHE96_15035 ENOG4105C6T cysteine synthase BHE96_15040 ENOG4107QSE Dipeptidase BHE96_15045 ENOG4105C7N Xanthine uracil vitamin C permease BHE96_15060 ENOG4105YW5 deoR family transcriptional regulator BHE96_15075 ENOG4105CBX hi0933 family BHE96_15080 ENOG4105C94 Transporter BHE96_15100 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component BHE96_15105 ENOG4105I1K ABC transporter BHE96_15120 ENOG41085GJ domain protein BHE96_15125 ENOG4105C8T Leucyl-tRNA synthetase BHE96_15135 ENOG4105BZU Histidine kinase BHE96_15140 ENOG410605W Major Facilitator BHE96_15155 ENOG4105C19 ABC transporter BHE96_15160 ENOG4105EWM Histidine kinase BHE96_15170 ENOG4107R34 abc transporter permease protein BHE96_15175 ENOG4105C19 ABC transporter BHE96_15195 ENOG4105DVE abc transporter atp-binding protein BHE96_15200 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family BHE96_15210 ENOG4105N5T Radical SAM Protein BHE96_15230 ENOG4105E8V Alpha Beta Hydrolase Fold protein BHE96_15235 ENOG4108Z0R Transferase BHE96_15240 ENOG4105C85 amino acid BHE96_15245 ENOG4105CAQ asparagine synthetase BHE96_15250 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BHE96_15255 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase BHE96_15270 ENOG4105D2X ABC transporter substrate-binding protein BHE96_15280 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BHE96_15295 ENOG4108RMU ferritin dps family protein BHE96_15310 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BHE96_15315 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BHE96_15320 ENOG4108V2W Carbonate dehydratase BHE96_15325 ENOG4105NRA 50s ribosomal protein l31 type b BHE96_15350 ENOG4105DTQ mandelate racemase muconate lactonizing BHE96_15355 ENOG4105CEY Amp-dependent synthetase and ligase BHE96_15360 ENOG4108IPT Naphthoate synthase BHE96_15365 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) BHE96_15370 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) BHE96_15375 ENOG4105E4F Isochorismate synthase BHE96_15510 ENOG4105N67 Proton-coupled thiamine transporter YuaJ BHE96_15515 ENOG4105DZ6 Band 7 protein BHE96_15525 ENOG4106DF1 BHE96_15530 ENOG4108VNY MOSC domain protein BHE96_15535 ENOG4108JB8 alcohol dehydrogenase BHE96_15540 ENOG4105C26 Dehydrogenase BHE96_15545 ENOG4105TRT Transcriptional regulator BHE96_15560 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj BHE96_15565 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BHE96_15585 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) BHE96_15595 ENOG4105EE0 oxidoreductase BHE96_15600 ENOG4108Z0Z intracellular protease Pfpi family BHE96_15605 ENOG4105C8Q Methyl-accepting chemotaxis BHE96_15610 ENOG4105C8Q Methyl-accepting chemotaxis BHE96_15615 ENOG4105C8Q Methyl-accepting chemotaxis BHE96_15620 ENOG4105C8Q Methyl-accepting chemotaxis BHE96_15635 ENOG4105EA8 2-Nitropropane dioxygenase BHE96_15640 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme BHE96_15650 ENOG4105C37 (CBS) domain BHE96_15665 ENOG4107PBV potassium channel BHE96_15670 ENOG4107PBV potassium channel BHE96_15685 ENOG4107QYV phosphohexose isomerase BHE96_15700 ENOG4105CHJ isochorismatase hydrolase BHE96_15710 ENOG4107QW4 alcohol dehydrogenase BHE96_15715 ENOG4105WG9 Conserved Protein BHE96_15725 ENOG4105CHM Aminotransferase BHE96_15730 ENOG4108ZB6 transcriptional regulator AsnC family BHE96_15735 ENOG4108MUZ hydrolase BHE96_15745 ENOG4105C87 Aminotransferase class I and II BHE96_15750 ENOG4108HGU Histidine kinase BHE96_15755 ENOG4105Y38 Kinase-associated protein B BHE96_15770 ENOG4105BZ4 penicillin-binding protein BHE96_15775 ENOG4105KIR Thiol-disulfide oxidoreductase dcc BHE96_15790 ENOG4108MRH transcriptional regulatory protein BHE96_15795 ENOG4105DIH basic membrane BHE96_15800 ENOG4108JQ9 ABC transporter BHE96_15805 ENOG4105UIB (ABC) transporter BHE96_15820 ENOG4105D65 subunit l BHE96_15825 ENOG4105HC0 Na H antiporter BHE96_15830 ENOG4108ZE9 Monovalent cation H antiporter subunit C BHE96_15835 ENOG4108JPZ Monovalent cation H antiporter subunit D BHE96_15840 ENOG4105SC1 monovalent cation H antiporter subunit E BHE96_15850 ENOG4105KJM monovalent cation h antiporter subunit g BHE96_15855 ENOG4105KA0 thioesterase Superfamily protein BHE96_15865 ENOG4105BZU Histidine kinase BHE96_15895 ENOG4105D58 Diguanylate phosphodiesterase BHE96_15900 ENOG4105DAP Nicotinate phosphoribosyltransferase BHE96_15925 ENOG4105C02 permease BHE96_15940 ENOG410904N short-chain dehydrogenase reductase BHE96_15975 ENOG4108K8K Transcriptional regulator BHE96_15980 ENOG4105DCF alanine dehydrogenase BHE96_15990 ENOG4105WQT MbtH domain protein BHE96_15995 ENOG4105CEY Amp-dependent synthetase and ligase BHE96_16000 ENOG4105WQI isochorismatase BHE96_16005 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BHE96_16010 ENOG4105E4F Isochorismate synthase BHE96_16015 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BHE96_16020 ENOG4105NIV Esterase BHE96_16040 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BHE96_16050 ENOG41069ER domain protein BHE96_16060 ENOG4105CEP NADH dehydrogenase BHE96_16075 ENOG4107SJ1 Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (By similarity) BHE96_16090 ENOG4105CJ1 ABC, transporter BHE96_16115 ENOG4108VHC Short-chain dehydrogenase reductase Sdr BHE96_16120 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BHE96_16125 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) BHE96_16135 ENOG4105ZKE UPF0349 protein BHE96_16150 ENOG41083MR nifu domain-containing protein BHE96_16155 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein BHE96_16160 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BHE96_16165 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) BHE96_16170 ENOG4105D6E homoserine dehydrogenase BHE96_16180 ENOG4108W5N phosphatidylglycerophosphatase a BHE96_16185 ENOG4105D4U had-superfamily hydrolase, subfamily iia BHE96_16195 ENOG4105MMD transcriptional regulator BHE96_16205 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) BHE96_16210 ENOG4105FAA peptidase M23 BHE96_16215 ENOG4108YTE sporulation protein YunB BHE96_16220 ENOG4107R8B 5'-nucleotidase BHE96_16230 ENOG4105I3N Conserved Protein BHE96_16240 ENOG4105CD3 dihydroorotase BHE96_16245 ENOG4105G9B Transcriptional regulator BHE96_16255 ENOG4105DQ6 Transposase BHE96_16280 ENOG4105C5R Aminotransferase BHE96_16290 ENOG4108K8S endonuclease I BHE96_16295 ENOG4108IJ9 (ABC) transporter BHE96_16300 ENOG4105FDP GntR family transcriptional regulator BHE96_16305 ENOG4108KPW sugar kinase BHE96_16310 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component BHE96_16315 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component BHE96_16320 ENOG4105XN3 extracellular solute-binding protein family 1 BHE96_16325 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine BHE96_16355 ENOG4105PKS Excinuclease abc c subunit domain protein BHE96_16360 ENOG4107VFR oxidoreductase BHE96_16365 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BHE96_16375 ENOG41083Q9 chitosanase BHE96_16380 ENOG4105DIW FeS assembly protein SUFB BHE96_16385 ENOG4108UNV SUF system FeS assembly protein, NifU family BHE96_16390 ENOG4105C9B Cysteine desulfurase BHE96_16395 ENOG4105JRK feS assembly protein SufD BHE96_16400 ENOG4105C3K feS assembly ATPase SufC BHE96_16410 ENOG4105D01 (LipO)protein BHE96_16415 ENOG4108UMI ABC transporter, permease BHE96_16420 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BHE96_16445 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BHE96_16450 ENOG41080E8 Transcriptional regulator, Spx MgsR family BHE96_16455 ENOG4105C1G acyl-Coa dehydrogenase BHE96_16460 ENOG4105CHU acetyl-coa acetyltransferase BHE96_16490 ENOG41067TZ transcriptional regulator, MarR family BHE96_16495 ENOG4105C0R drug resistance transporter emrb qaca subfamily BHE96_16500 ENOG4105C5Q Transcriptional regulator BHE96_16520 ENOG4105E0A ABC, transporter BHE96_16535 ENOG4105E1F short-chain dehydrogenase reductase BHE96_16540 ENOG4105HUF DNA protection during starvation protein BHE96_16545 ENOG4105C0H protease BHE96_16555 ENOG4105F3H Histidine kinase BHE96_16560 ENOG41067SE Tetr family transcriptional regulator BHE96_16565 ENOG4105C9Q fumarate hydratase class II BHE96_16590 ENOG4105WH1 Two component transcriptional regulator luxr family BHE96_16595 ENOG4105ENE Histidine kinase BHE96_16610 ENOG41087YS Phage shock protein A BHE96_16625 ENOG4108WBT adenosyltransferase BHE96_16630 ENOG4105E0A ABC, transporter BHE96_16635 ENOG4105EHG Permease protein BHE96_16640 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) BHE96_16645 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BHE96_16650 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein BHE96_16660 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BHE96_16670 ENOG4106DF4 Sigma-70, region 4 BHE96_16680 ENOG4105F0F Oxalate decarboxylase BHE96_16690 ENOG4105E0A ABC, transporter BHE96_16695 ENOG4105EHG Permease protein BHE96_16700 ENOG4105DQ5 transport system permease protein BHE96_16710 ENOG4105D5Q Arginine ornithine antiporter BHE96_16725 ENOG4107K5X Membrane-bound metal-dependent hydrolase BHE96_16730 ENOG4107QZ2 Sulfatase BHE96_16735 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family BHE96_16740 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BHE96_16745 ENOG4105E0C molybdate abc transporter BHE96_16750 ENOG4105WH1 Two component transcriptional regulator luxr family BHE96_16755 ENOG4105BZU Histidine kinase BHE96_16760 ENOG4105CJ1 ABC, transporter BHE96_16770 ENOG4108KYE ABC-2 type transporter BHE96_16790 ENOG4105DQ6 Transposase BHE96_16795 ENOG4105EEQ Na H antiporter BHE96_16805 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) BHE96_16810 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BHE96_16815 ENOG4105EEM helicase BHE96_16820 ENOG4105EN6 Membrane BHE96_16835 ENOG4107ZQN disulfide bond BHE96_16840 ENOG4105C59 p-type ATPase BHE96_16845 ENOG4105C59 p-type ATPase BHE96_16850 ENOG410681U heavy metal transport detoxification protein BHE96_16855 ENOG4105VPX protein, conserved in bacteria BHE96_16860 ENOG4105D9R oxidoreductase BHE96_16865 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BHE96_16905 ENOG4105DEN Luciferase family BHE96_16910 ENOG4105CDA abc transporter atp-binding protein BHE96_16935 ENOG4108XSB acetyltransferase, (GNAT) family BHE96_16940 ENOG4108KSA LysR family transcriptional regulator BHE96_16950 ENOG4105DQ6 Transposase BHE96_16955 ENOG4105EWI Short-chain dehydrogenase reductase Sdr BHE96_16970 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BHE96_16975 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BHE96_16985 ENOG4105XZU Preprotein translocase, subunit SecG BHE96_17005 ENOG4105KVH Transcriptional regulator BHE96_17030 ENOG4105DA5 (ABC) transporter BHE96_17035 ENOG4105R40 Glycine betaine carnitine choline BHE96_17040 ENOG4108HQR Glycine betaine BHE96_17045 ENOG4105E90 ABC transporter BHE96_17050 ENOG4108IJ8 ABC transporter BHE96_17055 ENOG4107HG4 Transcriptional regulator BHE96_17060 ENOG4105R40 Glycine betaine carnitine choline BHE96_17065 ENOG4108HQR Glycine betaine BHE96_17070 ENOG4105E90 ABC transporter BHE96_17075 ENOG4108IJ8 ABC transporter BHE96_17080 ENOG4107HG4 Transcriptional regulator BHE96_17085 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein BHE96_17100 ENOG4105T65 Membrane-associated protein BHE96_17105 ENOG4108W0I acetyltransferase BHE96_17120 ENOG4105FJR Lmbe family BHE96_17135 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BHE96_17140 ENOG4108IAJ Nad-dependent epimerase dehydratase BHE96_17145 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BHE96_17150 ENOG4107QQG Dehydrogenase BHE96_17155 ENOG4105IIU Aminopeptidase BHE96_17160 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BHE96_17165 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) BHE96_17170 ENOG4105CP7 Triose-phosphate isomerase BHE96_17175 ENOG4105BZA Phosphoglycerate kinase BHE96_17185 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BHE96_17200 ENOG4105CMD Transcriptional regulator, GntR family BHE96_17205 ENOG4105DEN Luciferase family BHE96_17215 ENOG4105GZI Transcriptional regulator BHE96_17220 ENOG4107RT3 EamA-like transporter family BHE96_17245 ENOG410667J hydrolase BHE96_17250 ENOG4106KNT transcriptional regulator BHE96_17255 ENOG4105CMG Carbohydrate kinase BHE96_17260 ENOG4105C6Z Gluconate BHE96_17270 ENOG4107QR9 Iron-sulfur cluster binding protein BHE96_17275 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BHE96_17280 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BHE96_17285 ENOG4105JXH GntR family transcriptional regulator BHE96_17290 ENOG4105DAA L-lactate BHE96_17295 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BHE96_17305 ENOG4108ZPC Polysaccharide pyruvyl transferase BHE96_17310 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BHE96_17315 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family BHE96_17320 ENOG4105D3Q Sugar transferase BHE96_17330 ENOG4105K64 Glycosyl transferase, family 2 BHE96_17340 ENOG4107QRS glycosyltransferase group 2 family protein BHE96_17345 ENOG41068W6 Capsular polysaccharide biosynthesis protein BHE96_17350 ENOG4108KMV Glycosyl transferase (Group 1 BHE96_17355 ENOG4105K64 Glycosyl transferase, family 2 BHE96_17360 ENOG4108PQP glycosyl transferase group 1 BHE96_17370 ENOG4108QV3 biosynthesis protein BHE96_17375 ENOG4105HTX biosynthesis protein BHE96_17385 ENOG4105EBR Carboxylesterase BHE96_17395 ENOG4105NAE bifunctional deaminase-reductase domain protein BHE96_17405 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 BHE96_17410 ENOG4105PY6 Phenolic acid decarboxylase BHE96_17415 ENOG4105NI3 Protein of unknown function (DUF3237) BHE96_17450 ENOG4108HKT sucrose-6-phosphate hydrolase BHE96_17455 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) BHE96_17460 ENOG4105ETE Transcriptional regulator (LacI family BHE96_17465 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) BHE96_17470 ENOG4108KAM Transcriptional regulator BHE96_17475 ENOG4105C7F AcnD-accessory protein PrpF BHE96_17485 ENOG4108URH decarboxylase BHE96_17490 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain BHE96_17495 ENOG4105CHH sulfate transporter BHE96_17500 ENOG4108V2W Carbonate dehydratase BHE96_17510 ENOG4105C5I Dehydrogenase BHE96_17515 ENOG4105GGE ribonuclease BHE96_17520 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BHE96_17530 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BHE96_17535 ENOG4105KRI phosphocarrier protein (HPr BHE96_17540 ENOG4105CIE May be required for sporulation (By similarity) BHE96_17545 ENOG4105CHW UPF0052 protein BHE96_17550 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) BHE96_17555 ENOG4108Z4K mutator MutT protein BHE96_17560 ENOG4105C3M thioredoxin reductase BHE96_17575 ENOG4105BZU Histidine kinase BHE96_17580 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BHE96_17585 ENOG4105BZ1 (ABC) transporter BHE96_17590 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase BHE96_17595 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) BHE96_17600 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase BHE96_17605 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BHE96_17610 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BHE96_17615 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) BHE96_17620 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BHE96_17625 ENOG4108IQ6 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) BHE96_17635 ENOG4108S4C acetyltransferase BHE96_17640 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) BHE96_17650 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) BHE96_17655 ENOG4105CE4 GlcNAc 6-P deacetylase BHE96_17660 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) BHE96_17665 ENOG4105FDP GntR family transcriptional regulator BHE96_17670 ENOG4105J7D transcriptional regulator BHE96_17675 ENOG41088CQ domain protein BHE96_17680 ENOG41086DT Membrane protein of unknown function BHE96_17685 ENOG41067S9 phage shock protein C, PspC BHE96_17690 ENOG4108PY7 BHE96_17705 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BHE96_17710 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) BHE96_17725 ENOG4105MKU Transcriptional regulator BHE96_17750 ENOG4105CN1 protease BHE96_17755 ENOG4108M26 parallel beta-helix repeat protein BHE96_17760 ENOG4105CRP Part of the ABC transporter FtsEX involved in BHE96_17765 ENOG4105CAK Cell division ATP-binding protein ftsE BHE96_17780 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BHE96_17785 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) BHE96_17790 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving BHE96_17795 ENOG4105MS2 ribosomal subunit Interface protein BHE96_17810 ENOG4105MQ3 flagellar protein FliS BHE96_17815 ENOG4107RT6 flagellar hook-associated BHE96_17820 ENOG4105I03 Flagellin BHE96_17825 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BHE96_17830 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) BHE96_17840 ENOG4105DTJ flagellar hook-associated protein BHE96_17845 ENOG4105E1Q flagellar hook-associated protein BHE96_17860 ENOG4105RU3 BHE96_17865 ENOG41081UC Inherit from COG: Competence protein BHE96_17885 ENOG4105WH1 Two component transcriptional regulator luxr family BHE96_17895 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BHE96_17900 ENOG4108KGH TRANSCRIPTIONal BHE96_17905 ENOG4105ESV Glycosyl transferase, family 4 BHE96_17910 ENOG4107EF8 Glycosyl transferase (Group 1 BHE96_17925 ENOG4105QZI O-Antigen Polymerase BHE96_17930 ENOG4105C6Y Udp-glucose 6-dehydrogenase BHE96_17935 ENOG4107RA4 Glycosyl transferase (Group 1 BHE96_17940 ENOG4105PSV Polysaccharide Biosynthesis Protein BHE96_17945 ENOG4105D3Q Sugar transferase BHE96_17950 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BHE96_17955 ENOG4105JFG SpoIID LytB domain protein BHE96_17965 ENOG4108KGH TRANSCRIPTIONal BHE96_17970 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BHE96_17975 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BHE96_17980 ENOG4105EY8 ABC transporter BHE96_17990 ENOG4107SJB teichoic acid biosynthesis BHE96_17995 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) BHE96_18000 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase BHE96_18010 ENOG4107RZX Teichoic acid biosynthesis protein BHE96_18020 ENOG4105DG6 mannose-6-phosphate isomerase BHE96_18035 ENOG4108NHD germination protein BHE96_18040 ENOG4107R8N Glycosyl transferase, family 2 BHE96_18045 ENOG4105C54 Major Facilitator superfamily BHE96_18050 ENOG4108KGH TRANSCRIPTIONal BHE96_18055 ENOG4105J7I hydrolase BHE96_18060 ENOG4106UBQ BHE96_18065 ENOG4105K4H Nlp p60 protein BHE96_18070 ENOG4105PNM synthesis protein BHE96_18080 ENOG4105N98 Capsule biosynthesis protein capB BHE96_18090 ENOG4105E1K spore germination protein BHE96_18105 ENOG4105ETE Transcriptional regulator (LacI family BHE96_18110 ENOG4108RVA ribokinase BHE96_18115 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) BHE96_18120 ENOG4105C2J ABC transporter BHE96_18125 ENOG4105CNN ABC, transporter BHE96_18130 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BHE96_18140 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BHE96_18145 ENOG4107FQX Alpha-acetolactate decarboxylase BHE96_18155 ENOG4107RSM transcriptional regulator BHE96_18170 ENOG4106UIA BHE96_18185 ENOG4107XC4 flavin reductase domain protein, FMN-binding BHE96_18195 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BHE96_18205 ENOG4105CAH Chromate BHE96_18210 ENOG4105FGV Chromate BHE96_18215 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) BHE96_18220 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) BHE96_18270 ENOG4108XI2 Domain of unknown function (DUF1963) BHE96_18275 ENOG4105C6Y Udp-glucose 6-dehydrogenase BHE96_18280 ENOG4108RB3 Capsular polysaccharide biosynthesis protein BHE96_18285 ENOG4107YJ4 chain length determinant protein BHE96_18290 ENOG4105HTX biosynthesis protein BHE96_18300 ENOG4105KBK Zinc finger, swim domain protein BHE96_18305 ENOG4105C0D helicase BHE96_18310 ENOG410667J hydrolase BHE96_18315 ENOG4105E98 transcriptional regulator DeoR family BHE96_18320 ENOG4105Z8H single-stranded DNA-binding protein BHE96_18335 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) BHE96_18340 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BHE96_18350 ENOG4105CGA flagellar basal-body rod protein FlgG BHE96_18360 ENOG4105DFF Rod shape-determining protein mreb BHE96_18365 ENOG4105MT0 Sporulation transcriptional regulator spoiiid BHE96_18370 ENOG4107MII Sugar-specific transcriptional regulator TrmB BHE96_18375 ENOG4105CZM Major Facilitator BHE96_18380 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease BHE96_18385 ENOG41080V3 Major Facilitator superfamily BHE96_18390 ENOG4105D3W isochorismatase BHE96_18395 ENOG4105BZU Histidine kinase BHE96_18405 ENOG4105CNI cell division protein FtsW BHE96_18410 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BHE96_18420 ENOG4105FRN stage II sporulation protein BHE96_18425 ENOG4107TCE N-acetyltransferase BHE96_18440 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BHE96_18445 ENOG4106BRK BHE96_18455 ENOG4107T94 Endo-14-beta-xylanase BHE96_18465 ENOG4108Z40 Transcriptional regulator BHE96_18470 ENOG4105CQM Urea amidohydrolase subunit alpha BHE96_18475 ENOG4105KI2 Urea amidohydrolase subunit beta BHE96_18480 ENOG4108YZ9 Urea amidohydrolase subunit gamma BHE96_18500 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) BHE96_18505 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) BHE96_18510 ENOG4108TF4 von Willebrand factor, type A BHE96_18525 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BHE96_18535 ENOG4106778 Protein of unknown function (DUF1146) BHE96_18545 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BHE96_18550 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BHE96_18555 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) BHE96_18560 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) BHE96_18565 ENOG4107YZM F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BHE96_18580 ENOG4107RFS it plays a direct role in the translocation of protons across the membrane (By similarity) BHE96_18590 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BHE96_18595 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) BHE96_18600 ENOG4108UIC UPF0340 protein BHE96_18605 ENOG4108YZG isomerase BHE96_18610 ENOG4107WAU Protein tyrosine phosphatase BHE96_18615 ENOG410815N Probably functions as a manganese efflux pump (By similarity) BHE96_18620 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BHE96_18630 ENOG4108ZXQ stage ii sporulation protein r BHE96_18645 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BHE96_18650 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BHE96_18655 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BHE96_18665 ENOG4107TT2 Auxin Efflux Carrier BHE96_18670 ENOG4105C6K Malic enzyme BHE96_18675 ENOG4107104 thymidine kinase BHE96_18680 ENOG41082DI 50s ribosomal protein l31 BHE96_18685 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BHE96_18690 ENOG4105CBT Fructose-1,6-bisphosphatase BHE96_18695 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BHE96_18705 ENOG4105D2N Aldolase BHE96_18710 ENOG410812K response regulator receiver protein BHE96_18720 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BHE96_18730 ENOG4105DF6 Fe-S oxidoreductase BHE96_18740 ENOG4105E5J UV damage endonuclease BHE96_18750 ENOG4105BZ1 (ABC) transporter BHE96_18770 ENOG4105R3A Nitrate reductase BHE96_18775 ENOG4108IUE nitrate reductase beta subunit BHE96_18795 ENOG4107V6Q Cyclic nucleotide-binding domain BHE96_18805 ENOG4105C75 arginyL-tRNA synthetase BHE96_18810 ENOG410684U Domain of unknown function (DUF1934) BHE96_18835 ENOG4107JM4 Tetratricopeptide repeat BHE96_18880 ENOG4105CYW agmatinase BHE96_18885 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) BHE96_18890 ENOG4105BZ4 penicillin-binding protein BHE96_18900 ENOG4108XFG YwhD family BHE96_18905 ENOG4108Z4T Peptidase M50 BHE96_18910 ENOG41069HH 4-oxalocrotonate tautomerase BHE96_18915 ENOG41067TZ transcriptional regulator, MarR family BHE96_18925 ENOG4105CUB amino acid BHE96_18935 ENOG4105DCI Phosphohydrolase BHE96_18945 ENOG4108VCI transcription factor, rsfa family BHE96_18950 ENOG4105K7K Transcriptional regulator BHE96_18960 ENOG4105CJ1 ABC, transporter BHE96_18965 ENOG4108TU7 Inherit from COG: (ABC) transporter BHE96_18990 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) BHE96_18995 ENOG4105DUM transcriptional regulator, lysR family BHE96_19000 ENOG4105HMI Membrane BHE96_19005 ENOG4108IJ2 phosphate acetyltransferase BHE96_19010 ENOG4107JTW chlorite dismutase BHE96_19020 ENOG4105CHM Aminotransferase BHE96_19050 ENOG4105FCW Major Facilitator superfamily BHE96_19055 ENOG4105C2C drug resistance transporter, Bcr CflA BHE96_19070 ENOG4105C26 Dehydrogenase BHE96_19075 ENOG4105D82 Glutamate dehydrogenase BHE96_19085 ENOG4105DPZ Two component transcriptional regulator (Winged helix family BHE96_19110 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase BHE96_19115 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase BHE96_19120 ENOG4105C1B dTDP-glucose 4-6-dehydratase BHE96_19125 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BHE96_19130 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG BHE96_19135 ENOG4107TY6 Acylneuraminate cytidylyltransferase BHE96_19145 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD BHE96_19150 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BHE96_19185 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BHE96_19190 ENOG4108RJ9 Glycosyl transferase, family 2 BHE96_19210 ENOG4105DWF phosphomethylpyrimidine kinase BHE96_19225 ENOG4105C5Y PTS System BHE96_19240 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin BHE96_19245 ENOG4105DEN Luciferase family BHE96_19250 ENOG4108DBC nitroreductase BHE96_19260 ENOG4105I4A GCN5-related N-acetyltransferase BHE96_19280 ENOG4105BZ9 Cytochrome C oxidase, subunit I BHE96_19285 ENOG4105E2S oxidase) subunit II BHE96_19290 ENOG4107BMA Transglycosylase associated protein BHE96_19300 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BHE96_19305 ENOG4105WH5 Teichoic acid glycosylation protein BHE96_19330 ENOG4107ZXU DSBA oxidoreductase BHE96_19335 ENOG4105DBE peroxidase BHE96_19340 ENOG410650H (LipO)protein BHE96_19345 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) BHE96_19350 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase BHE96_19355 ENOG4105CMU LysR family (Transcriptional regulator BHE96_19360 ENOG4105VAW lrga family BHE96_19365 ENOG41067MG lrgb family BHE96_19375 ENOG4107TXC Transcriptional regulator BHE96_19385 ENOG4105DR4 Methyltransferase BHE96_19395 ENOG4105CK1 PTS System BHE96_19400 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin BHE96_19405 ENOG4105X1N Glycosyl transferase family 8 BHE96_19420 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BHE96_19435 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) BHE96_19440 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein BHE96_19445 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) BHE96_19450 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD BHE96_19455 ENOG4105CM2 brancheD-chain amino acid aminotransferase BHE96_19460 ENOG4105F8D glycoside hydrolase family 4 BHE96_19465 ENOG4105VCP PTS System BHE96_19470 ENOG4105CK1 PTS System BHE96_19475 ENOG4105VZJ PTS System BHE96_19480 ENOG4105EMD TRANSCRIPTIONal BHE96_19495 ENOG4105DQ5 transport system permease protein BHE96_19500 ENOG4105EHG Permease protein BHE96_19510 ENOG41082YX Transcriptional regulator, arsr family BHE96_19515 ENOG4107R5R arsenical pump membrane protein BHE96_19520 ENOG4105VZJ PTS System BHE96_19525 ENOG4105VCP PTS System BHE96_19530 ENOG4105CK1 PTS System BHE96_19535 ENOG4105CS2 ec 3.2.1.21 BHE96_19540 ENOG4105EVU fructokinase BHE96_19545 ENOG4105DG6 mannose-6-phosphate isomerase BHE96_19555 ENOG4105CH6 catalase BHE96_19560 ENOG4107QHE Choloylglycine hydrolase BHE96_19565 ENOG4105ETS cytosine purines uracil thiamine allantoin BHE96_19570 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) BHE96_19575 ENOG4108JJ8 (ABC) transporter BHE96_19580 ENOG4108JJ9 ABC, transporter BHE96_19585 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BHE96_19590 ENOG4105C4M (Ubiquinol oxidase) subunit I BHE96_19595 ENOG4105D2K citrate carrier protein BHE96_19600 ENOG4107BJW polysaccharide deacetylase BHE96_19615 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) BHE96_19625 ENOG4105CMR udp-glucose 4-epimerase BHE96_19630 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BHE96_19645 ENOG4105DHI Methyltransferase BHE96_19665 ENOG4105CH6 catalase BHE96_19670 ENOG4105D4T Citrate transporter BHE96_19680 ENOG4105CID antiterminator BHE96_19685 ENOG4105DEU major facilitator superfamily BHE96_19690 ENOG4105C1J atp-dependent rna helicase BHE96_19775 ENOG4108NR7 pectate lyase BHE96_19785 ENOG4107YZX Universal stress protein BHE96_19790 ENOG4105CS2 ec 3.2.1.21 BHE96_19795 ENOG4105C5Y PTS System BHE96_19805 ENOG4105M6F mutator MutT protein BHE96_19810 ENOG4106Z5D Glycoside Hydrolase Family 43 BHE96_19820 ENOG4105C84 Histidine ammonia-lyase BHE96_19825 ENOG4105CGP Urocanate hydratase BHE96_19830 ENOG4105CI2 imidazolone-5-propionate hydrolase BHE96_19835 ENOG4107W25 arginase agmatinase formiminoglutamase BHE96_19845 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) BHE96_19850 ENOG4105D9N nucleoside BHE96_19855 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BHE96_19860 ENOG4107RHR regulatoR BHE96_19865 ENOG410667J hydrolase BHE96_19895 ENOG4108V5C ABC transporter BHE96_19930 ENOG4105WZ4 isomerase BHE96_19935 ENOG4105F0H myo-inositol catabolism protein BHE96_19940 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BHE96_19950 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) BHE96_19960 ENOG4105EDK PfkB domain protein BHE96_19970 ENOG4105C26 Dehydrogenase BHE96_19980 ENOG4105CPC Aldo Keto reductase BHE96_19985 ENOG4107QNK )-transporter BHE96_19990 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BHE96_20000 ENOG41061TZ Short-chain dehydrogenase reductase Sdr BHE96_20005 ENOG4108S01 response regulator BHE96_20010 ENOG4108ZGX Histidine kinase BHE96_20015 ENOG4105ECK Fatty Acid Desaturase BHE96_20025 ENOG4105ST3 Transcriptional regulator BHE96_20030 ENOG4105C26 Dehydrogenase BHE96_20035 ENOG4108ITS PQQ enzyme repeat BHE96_20045 ENOG4105WAB arsR family transcriptional regulator BHE96_20050 ENOG4105F27 Major Facilitator BHE96_20055 ENOG41085PJ rdd domain containing protein BHE96_20065 ENOG4105D3R alkyl hydroperoxide reductase BHE96_20070 ENOG4108JU3 Alkyl hydroperoxide reductase BHE96_20075 ENOG4107R3N Filamentation induced by cAMP protein fic BHE96_20080 ENOG4105C85 amino acid BHE96_20085 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 BHE96_20090 ENOG4108XHQ (2Fe-2S)-binding domain protein BHE96_20110 ENOG4105XRQ Xanthine dehydrogenase accessory factor BHE96_20140 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BHE96_20160 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) BHE96_20165 ENOG4105CPC Aldo Keto reductase BHE96_20170 ENOG4105WQG acetyltransferase BHE96_20180 ENOG41066UZ arginase EC 3.5.3.1 BHE96_20185 ENOG4108IQI permease BHE96_20190 ENOG4105C8Y Acetylornithine aminotransferase BHE96_20200 ENOG41082BM Transcriptional regulator, arsr family BHE96_20205 ENOG4108JUB Transcriptional regulator BHE96_20215 ENOG4105C5H ABC transporter BHE96_20230 ENOG4105D06 uba thif-type nad fad binding protein BHE96_20235 ENOG41062D9 Histidine kinase BHE96_20240 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BHE96_20245 ENOG4105C0H protease BHE96_20250 ENOG4105Q2H domain protein BHE96_20265 ENOG4105BZU Histidine kinase BHE96_20270 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BHE96_20300 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BHE96_20305 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BHE96_20310 ENOG4105CDU Replicative dna helicase BHE96_20335 ENOG4105EDW glycosyl transferase, family 39 BHE96_20350 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR BHE96_20355 ENOG4105CPK Glycosyl transferase (Group 1 BHE96_20375 ENOG4105BZR domain protein BHE96_20380 ENOG4108XMW Membrane BHE96_20390 ENOG4105KVH Transcriptional regulator BHE96_20395 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase BHE96_20400 ENOG4108UZ3 Transporter BHE96_20405 ENOG4105EDQ levansucrase EC 2.4.1.10 BHE96_20410 ENOG4108HKT sucrose-6-phosphate hydrolase BHE96_20415 ENOG4107XBN GntR Family Transcriptional Regulator BHE96_20430 ENOG4107V2S Transcriptional regulator BHE96_20435 ENOG4108VP3 Lysine exporter protein (LysE YggA) BHE96_20445 ENOG4107RSM transcriptional regulator BHE96_20455 ENOG4108TVJ Nitroreductase BHE96_20460 ENOG4105FS7 Transcriptional regulator BHE96_20470 ENOG4108U05 Transcriptional regulator BHE96_20475 ENOG41082BV acetyltransferase BHE96_20485 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase BHE96_20490 ENOG4105CMU LysR family (Transcriptional regulator BHE96_20515 ENOG4107Y9U Membrane BHE96_20520 ENOG4105C7Z Conserved Protein BHE96_20525 ENOG4107FCW Abortive infection protein BHE96_20535 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BHE96_20545 ENOG4105CGK Exodeoxyribonuclease III BHE96_20550 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BHE96_20560 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) BHE96_20565 ENOG4108UUM single-stranded DNA-binding protein BHE96_20570 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) BHE96_20575 ENOG4105C3G gtp-binding protein BHE96_20580 ENOG4108J2R molybdopterin oxidoreductase BHE96_20585 ENOG4105VDK protein, conserved in bacteria BHE96_20600 ENOG4108ZDA Sporulation protein YyaC BHE96_20605 ENOG4105FA0 parb-like partition protein BHE96_20610 ENOG4107QJE Chromosome Partitioning Protein BHE96_20625 ENOG4105CWE NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BHE96_20630 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) BHE96_20645 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)