locus-tag	class	description
HR084_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HR084_00010	COG0592	DNA-directed DNA polymerase activity
HR084_00015	COG2501	S4 domain
HR084_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HR084_00030	COG0187	DNA topoisomerase II activity
HR084_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HR084_00070	COG0516	GMP reductase activity
HR084_00070	COG0517	IMP dehydrogenase activity
HR084_00075	COG1686	Belongs to the peptidase S11 family
HR084_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HR084_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HR084_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HR084_00100	COG1428	Deoxynucleoside kinase
HR084_00105	COG1428	Deoxynucleoside kinase
HR084_00110	COG3858	chitin binding
HR084_00110	COG1388	LysM domain
HR084_00115	COG1335	isochorismatase
HR084_00120	COG0590	tRNA wobble adenosine to inosine editing
HR084_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HR084_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HR084_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HR084_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HR084_00190	COG3853	Toxic anion resistance protein (TelA)
HR084_00195	COG1982	Orn Lys Arg decarboxylase major
HR084_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HR084_00205	COG3870	Protein conserved in bacteria
HR084_00210	COG1728	Protein conserved in bacteria
HR084_00215	COG0470	DNA polymerase III
HR084_00220	COG1774	PSP1 C-terminal conserved region
HR084_00225	COG4467	Involved in initiation control of chromosome replication
HR084_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HR084_00235	COG2827	Endonuclease containing a URI domain
HR084_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HR084_00245	COG2002	toxin-antitoxin pair type II binding
HR084_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HR084_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HR084_00255	COG0084	hydrolase, TatD family'
HR084_00260	COG3584	3D domain protein
HR084_00260	COG3583	domain protein
HR084_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HR084_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HR084_00280	COG4466	Protein conserved in bacteria
HR084_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HR084_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HR084_00300	COG0251	oxidation-reduction process
HR084_00305	COG2088	sporulation resulting in formation of a cellular spore
HR084_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HR084_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HR084_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HR084_00325	COG0193	aminoacyl-tRNA hydrolase activity
HR084_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HR084_00340	COG2002	toxin-antitoxin pair type II binding
HR084_00345	COG2244	polysaccharide biosynthetic process
HR084_00350	COG3956	TIGRFAM MazG family protein
HR084_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HR084_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HR084_00375	COG1098	S1 RNA binding domain
HR084_00390	COG2208	phosphoserine phosphatase activity
HR084_00395	COG2304	oxidoreductase activity
HR084_00400	COG0515	serine threonine protein kinase
HR084_00405	COG0037	tRNA processing
HR084_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HR084_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HR084_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HR084_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HR084_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HR084_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HR084_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
HR084_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HR084_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HR084_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HR084_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HR084_00470	COG1396	sequence-specific DNA binding
HR084_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HR084_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HR084_00560	COG4463	regulation of RNA biosynthetic process
HR084_00565	COG3880	PFAM UvrB UvrC protein
HR084_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HR084_00575	COG0542	response to heat
HR084_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HR084_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HR084_00590	COG4956	integral membrane protein (PIN domain superfamily)
HR084_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HR084_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HR084_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HR084_00610	COG1045	serine acetyltransferase
HR084_00615	COG0215	cysteine-tRNA ligase activity
HR084_00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HR084_00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HR084_00630	COG3688	RNA-binding protein containing a PIN domain
HR084_00635	COG1595	DNA-templated transcription, initiation
HR084_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HR084_00650	COG0250	Participates in transcription elongation, termination and antitermination
HR084_00660	COG0081	regulation of translation
HR084_00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HR084_00675	COG2813	Specifically methylates the guanine in position
HR084_00680	COG0085	RNA polymerase activity
HR084_00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HR084_00690	COG1358	cellular component organization or biogenesis
HR084_00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HR084_00700	COG0049	tRNA binding
HR084_00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HR084_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HR084_00715	COG0596	Alpha beta hydrolase
HR084_00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HR084_00730	COG0088	Forms part of the polypeptide exit tunnel
HR084_00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HR084_00755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HR084_00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HR084_00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HR084_00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HR084_00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HR084_00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HR084_00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HR084_00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HR084_00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HR084_00820	COG0200	Binds to the 23S rRNA
HR084_00825	COG0201	protein transport
HR084_00830	COG0563	adenylate kinase activity
HR084_00835	COG0024	Methionine aminopeptidase
HR084_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HR084_00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HR084_00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HR084_00865	COG0202	RNA polymerase activity
HR084_00870	COG0203	ribosomal protein L17
HR084_00875	COG1122	ATPase activity
HR084_00880	COG1122	ATPase activity
HR084_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HR084_00890	COG0101	tRNA pseudouridine synthase activity
HR084_00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HR084_00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HR084_00905	COG2226	methyltransferase
HR084_00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
HR084_00920	COG0489	protein tyrosine kinase activity
HR084_00930	COG2194	sulfuric ester hydrolase activity
HR084_00935	COG0726	polysaccharide deacetylase
HR084_01090	COG0659	secondary active sulfate transmembrane transporter activity
HR084_01095	COG0385	Bile acid
HR084_01100	COG2819	hydrolase of the alpha beta superfamily
HR084_01105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HR084_01110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HR084_01115	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HR084_01120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HR084_01120	COG2207	Transcriptional regulator
HR084_01125	COG3876	Protein conserved in bacteria
HR084_01130	COG1472	Belongs to the glycosyl hydrolase 3 family
HR084_01135	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HR084_01140	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HR084_01140	COG1263	PTS System
HR084_01145	COG1737	Transcriptional regulator
HR084_01150	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HR084_01155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HR084_01160	COG1683	Conserved Protein
HR084_01190	COG1595	DNA-templated transcription, initiation
HR084_01195	COG5662	AntiSigma factor
HR084_01200	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HR084_01205	COG4856	YbbR-like protein
HR084_01210	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HR084_01215	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HR084_01225	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HR084_01230	COG2169	Transcriptional regulator
HR084_01235	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HR084_01240	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HR084_01245	COG3002	Belongs to the UPF0753 family
HR084_01250	COG0288	reversible hydration of carbon dioxide
HR084_01260	COG5609	conserved protein (DUF2294)
HR084_01265	COG0640	Transcriptional regulator
HR084_01270	COG2814	Major facilitator Superfamily
HR084_01285	COG0596	Alpha beta hydrolase
HR084_01290	COG0745	RESPONSE REGULATOR receiver
HR084_01295	COG0642	Histidine kinase
HR084_01305	COG0515	serine threonine protein kinase
HR084_01320	COG1113	amino acid transport
HR084_01335	COG2602	Beta-lactamase
HR084_01340	COG2124	cytochrome p450
HR084_01350	COG0531	amino acid
HR084_01355	COG0584	glycerophosphoryl diester phosphodiesterase
HR084_01360	COG2271	Major facilitator Superfamily
HR084_01370	COG0456	acetyltransferase
HR084_01370	COG1846	Transcriptional regulator
HR084_01375	COG2271	Major facilitator Superfamily
HR084_01385	COG3409	Peptidoglycan-binding domain 1 protein
HR084_01390	COG0697	spore germination
HR084_01395	COG2207	Transcriptional regulator
HR084_01395	COG1917	Cupin 2, conserved barrel domain protein
HR084_01400	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HR084_01405	COG3591	Belongs to the peptidase S1B family
HR084_01415	COG0596	Alpha beta hydrolase
HR084_01420	COG1183	phosphatidylcholine synthase activity
HR084_01425	COG0586	Pfam SNARE associated Golgi protein
HR084_01430	COG0688	phosphatidylethanolamine metabolic process
HR084_01440	COG2312	Erythromycin esterase
HR084_01450	COG1301	dicarboxylic acid transport
HR084_01455	COG1263	PTS System
HR084_01455	COG2190	(PTS) system
HR084_01455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HR084_01460	COG0363	glucosamine-6-phosphate deaminase activity
HR084_01465	COG2188	Transcriptional regulator
HR084_01475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HR084_01480	COG0833	amino acid
HR084_01485	COG2040	homocysteine
HR084_01490	COG1115	amino acid carrier protein
HR084_01495	COG2066	Belongs to the glutaminase family
HR084_01500	COG4191	Histidine kinase
HR084_01505	COG0784	Response regulator, receiver
HR084_01510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HR084_01515	COG1012	belongs to the aldehyde dehydrogenase family
HR084_01520	COG2271	Major facilitator Superfamily
HR084_01525	COG4948	Mandelate Racemase Muconate Lactonizing
HR084_01530	COG2186	Transcriptional regulator
HR084_01535	COG2721	sulfolactate sulfo-lyase activity
HR084_01540	COG3173	Aminoglycoside phosphotransferase
HR084_01550	COG0697	spore germination
HR084_01555	COG0745	RESPONSE REGULATOR receiver
HR084_01560	COG2205	protein histidine kinase activity
HR084_01565	COG1131	(ABC) transporter
HR084_01585	COG3773	Cell wall hydrolase
HR084_01590	COG2304	oxidoreductase activity
HR084_01600	COG3540	Alkaline phosphatase
HR084_01605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HR084_01610	COG0805	protein transport
HR084_01615	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HR084_01620	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HR084_01625	COG0477	Major facilitator Superfamily
HR084_01630	COG1309	transcriptional regulator
HR084_01635	COG0252	asparaginase activity
HR084_01640	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HR084_01645	COG1714	RDD family
HR084_01650	COG3012	SEC-C Motif Domain Protein
HR084_01650	COG1405	negative regulation of cell septum assembly
HR084_01655	COG3290	protein histidine kinase activity
HR084_01660	COG3279	Response regulator of the LytR AlgR family
HR084_01665	COG4555	ABC transporter
HR084_01670	COG1668	transmembrane transport
HR084_01675	COG0667	Aldo Keto reductase
HR084_01690	COG1595	DNA-templated transcription, initiation
HR084_01695	COG1595	DNA-templated transcription, initiation
HR084_01700	COG1876	peptidase activity
HR084_01705	COG0457	Tetratricopeptide repeat
HR084_01710	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_01715	COG0366	Alpha amylase catalytic
HR084_01720	COG0803	Belongs to the bacterial solute-binding protein 9 family
HR084_01725	COG1121	(ABC) transporter
HR084_01730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HR084_01735	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HR084_01740	COG2310	stress, protein
HR084_01745	COG2310	stress, protein
HR084_01750	COG2310	stress, protein
HR084_01755	COG0861	Integral membrane protein TerC family
HR084_01765	COG3853	Toxic anion resistance protein (TelA)
HR084_01770	COG0477	Major facilitator Superfamily
HR084_01775	COG2814	Major facilitator Superfamily
HR084_01780	COG0640	Transcriptional regulator
HR084_01785	COG0517	IMP dehydrogenase activity
HR084_01785	COG4175	Glycine betaine
HR084_01790	COG4176	ABC-type proline glycine betaine transport system permease component
HR084_01795	COG2113	Glycine betaine
HR084_01800	COG1473	amidohydrolase
HR084_01805	COG1288	antiporter activity
HR084_01815	COG0366	Alpha amylase catalytic
HR084_01820	COG0039	L-malate dehydrogenase activity
HR084_01825	COG1620	l-lactate permease
HR084_01830	COG2814	Major facilitator Superfamily
HR084_01835	COG1846	Transcriptional regulator
HR084_01840	COG1280	lysine exporter protein (LysE YggA)
HR084_01845	COG3403	YqcI/YcgG family
HR084_01850	COG1113	amino acid transport
HR084_01855	COG3665	Urea carboxylase-associated protein
HR084_01860	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HR084_01865	COG1660	Displays ATPase and GTPase activities
HR084_01870	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HR084_01875	COG2226	methyltransferase
HR084_01880	COG0583	DNA-binding transcription factor activity
HR084_01885	COG3458	cephalosporin-C deacetylase activity
HR084_01890	COG3541	Predicted nucleotidyltransferase
HR084_01895	COG0506	proline dehydrogenase activity
HR084_01900	COG1012	belongs to the aldehyde dehydrogenase family
HR084_01905	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HR084_01910	COG2508	Transcriptional regulator
HR084_01915	COG3689	TIGRFAM TIGR03943 family protein
HR084_01920	COG0701	Predicted permease
HR084_01925	COG2267	carboxylic ester hydrolase activity
HR084_01930	COG0492	ferredoxin-NADP+ reductase activity
HR084_01935	COG1587	Uroporphyrinogen-III synthase
HR084_01935	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HR084_01940	COG2146	nitrite reductase [NAD(P)H] activity
HR084_01945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HR084_01950	COG0243	molybdopterin cofactor binding
HR084_01955	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HR084_01960	COG2223	nitrite transmembrane transporter activity
HR084_01965	COG1469	GTP cyclohydrolase I activity
HR084_01970	COG1376	ErfK ybiS ycfS ynhG family protein
HR084_01985	COG0523	cobalamin synthesis protein
HR084_01990	COG0765	amino acid transport
HR084_01995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HR084_02005	COG1714	RDD family
HR084_02015	COG2723	6-phospho-beta-galactosidase activity
HR084_02025	COG3209	COG3209 Rhs family protein
HR084_02030	COG0840	transmembrane signaling receptor activity
HR084_02030	COG3290	protein histidine kinase activity
HR084_02035	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HR084_02040	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HR084_02045	COG1733	regulation of RNA biosynthetic process
HR084_02050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HR084_02055	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HR084_02060	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HR084_02065	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HR084_02070	COG2814	Major facilitator Superfamily
HR084_02080	COG0697	spore germination
HR084_02085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HR084_02095	COG2364	Membrane
HR084_02100	COG1126	abc transporter atp-binding protein
HR084_02105	COG0765	amino acid transport
HR084_02110	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HR084_02115	COG0583	DNA-binding transcription factor activity
HR084_02120	COG0163	prenyltransferase activity
HR084_02125	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HR084_02140	COG0596	Alpha beta hydrolase
HR084_02145	COG3104	oligopeptide transport
HR084_02150	COG5434	Belongs to the glycosyl hydrolase 28 family
HR084_02160	COG0697	spore germination
HR084_02170	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HR084_02175	COG1136	(ABC) transporter
HR084_02180	COG0577	efflux transmembrane transporter activity
HR084_02185	COG0745	RESPONSE REGULATOR receiver
HR084_02190	COG5002	protein histidine kinase activity
HR084_02190	COG3850	Histidine kinase
HR084_02195	COG0457	Tetratricopeptide repeat
HR084_02215	COG0527	aspartate kinase activity
HR084_02220	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HR084_02225	COG4605	iron ion homeostasis
HR084_02230	COG4604	ABC transporter, ATP-binding protein
HR084_02235	COG4607	ABC-type enterochelin transport system periplasmic component
HR084_02240	COG2814	Major facilitator Superfamily
HR084_02245	COG1309	transcriptional regulator
HR084_02250	COG0778	Nitroreductase
HR084_02255	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HR084_02260	COG0640	Transcriptional regulator
HR084_02265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HR084_02270	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HR084_02275	COG1012	belongs to the aldehyde dehydrogenase family
HR084_02280	COG4975	Glucose uptake
HR084_02285	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_02290	COG4549	nuclear export factor GLE1
HR084_02295	COG2372	response to copper ion
HR084_02295	COG1276	copper resistance
HR084_02300	COG1349	DNA-binding transcription factor activity
HR084_02310	COG2213	PTS system mannitol-specific
HR084_02315	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HR084_02320	COG0246	Mannitol dehydrogenase
HR084_02325	COG0473	3-isopropylmalate dehydrogenase activity
HR084_02330	COG0681	Belongs to the peptidase S26 family
HR084_02335	COG0412	Dienelactone hydrolase
HR084_02340	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HR084_02350	COG0561	phosphatase activity
HR084_02355	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HR084_02360	COG1914	H( )-stimulated, divalent metal cation uptake system
HR084_02365	COG4336	lyase activity
HR084_02370	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HR084_02375	COG1984	allophanate hydrolase subunit 2
HR084_02380	COG1414	Transcriptional regulator
HR084_02385	COG2755	lipolytic protein G-D-S-L family
HR084_02395	COG2329	Antibiotic biosynthesis monooxygenase
HR084_02400	COG0768	penicillin binding
HR084_02405	COG4989	oxidoreductase activity
HR084_02410	COG3711	transcriptional antiterminator
HR084_02415	COG0318	PFAM AMP-dependent synthetase and ligase
HR084_02420	COG2226	methyltransferase
HR084_02425	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_02430	COG1917	Cupin 2, conserved barrel domain protein
HR084_02435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HR084_02440	COG3871	stress protein (general stress protein 26)
HR084_02450	COG2814	Major facilitator Superfamily
HR084_02455	COG1522	sequence-specific DNA binding
HR084_02460	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HR084_02460	COG0551	DNA topoisomerase type I activity
HR084_02465	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HR084_02470	COG3706	GGDEF domain
HR084_02475	COG5298	Protein conserved in bacteria
HR084_02480	COG1215	transferase activity, transferring glycosyl groups
HR084_02490	COG0531	amino acid
HR084_02495	COG0494	nUDIX hydrolase
HR084_02500	COG0028	Belongs to the TPP enzyme family
HR084_02525	COG1914	H( )-stimulated, divalent metal cation uptake system
HR084_02530	COG2261	transglycosylase associated protein
HR084_02535	COG4876	unkown
HR084_02540	COG2217	Heavy metal translocating P-type atpase
HR084_02545	COG3729	General stress protein
HR084_02550	COG0662	Cupin 2, conserved barrel domain protein
HR084_02555	COG2329	Antibiotic biosynthesis monooxygenase
HR084_02560	COG3546	catalase activity
HR084_02565	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HR084_02570	COG3290	protein histidine kinase activity
HR084_02575	COG4565	transcriptional regulatory protein
HR084_02580	COG1301	dicarboxylic acid transport
HR084_02585	COG0628	permease
HR084_02595	COG1131	(ABC) transporter
HR084_02600	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HR084_02610	COG1960	acyl-CoA dehydrogenase activity
HR084_02625	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HR084_02630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HR084_02635	COG1181	Belongs to the D-alanine--D-alanine ligase family
HR084_02640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HR084_02645	COG0513	Belongs to the DEAD box helicase family
HR084_02650	COG3402	PFAM membrane-flanked domain
HR084_02655	COG3428	Bacterial PH domain
HR084_02660	COG0705	Rhomboid family
HR084_02665	COG0736	holo-[acyl-carrier-protein] synthase activity
HR084_02670	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HR084_02675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HR084_02680	COG0864	Transcriptional regulator
HR084_02685	COG2337	Toxic component of a toxin-antitoxin (TA) module
HR084_02690	COG1366	Belongs to the anti-sigma-factor antagonist family
HR084_02695	COG1366	Belongs to the anti-sigma-factor antagonist family
HR084_02700	COG2172	sigma factor antagonist activity
HR084_02705	COG2208	phosphoserine phosphatase activity
HR084_02710	COG1366	Belongs to the anti-sigma-factor antagonist family
HR084_02715	COG2172	sigma factor antagonist activity
HR084_02720	COG1191	sigma factor activity
HR084_02725	COG2208	phosphoserine phosphatase activity
HR084_02740	COG1673	EVE domain
HR084_02745	COG1846	Transcriptional regulator
HR084_02750	COG2183	response to ionizing radiation
HR084_02760	COG3091	SprT-like family
HR084_02815	COG5444	nuclease activity
HR084_02820	COG1476	TRANSCRIPTIONal
HR084_02830	COG3239	Fatty acid desaturase
HR084_02835	COG1278	Cold shock
HR084_02845	COG0697	spore germination
HR084_02850	COG2207	Transcriptional regulator
HR084_02850	COG1917	Cupin 2, conserved barrel domain protein
HR084_02855	COG0697	spore germination
HR084_02860	COG2207	Transcriptional regulator
HR084_02860	COG3708	Transcriptional regulator
HR084_02865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HR084_02870	COG0477	Major facilitator Superfamily
HR084_02880	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HR084_02890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HR084_02895	COG1309	transcriptional regulator
HR084_02900	COG0697	spore germination
HR084_02905	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HR084_02910	COG2030	dehydratase
HR084_02915	COG3545	Serine hydrolase
HR084_02920	COG1733	regulation of RNA biosynthetic process
HR084_02925	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HR084_02930	COG1733	regulation of RNA biosynthetic process
HR084_02935	COG2249	NAD(P)H dehydrogenase (quinone) activity
HR084_02940	COG2814	Major facilitator Superfamily
HR084_02945	COG1309	transcriptional regulator
HR084_02950	COG0640	Transcriptional regulator
HR084_02955	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HR084_02965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HR084_02970	COG0697	spore germination
HR084_02975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HR084_02980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HR084_02985	COG0640	Transcriptional regulator
HR084_02990	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HR084_03005	COG4585	Histidine kinase
HR084_03010	COG2197	response regulator
HR084_03015	COG2409	Drug exporters of the RND superfamily
HR084_03020	COG0596	Alpha beta hydrolase
HR084_03025	COG1811	Na channel or pump
HR084_03030	COG0789	Transcriptional regulator
HR084_03030	COG4978	Transcriptional regulator
HR084_03035	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HR084_03040	COG0778	Nitroreductase
HR084_03045	COG0346	lactoylglutathione lyase activity
HR084_03050	COG2259	Doxx family
HR084_03055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HR084_03070	COG2323	membrane
HR084_03075	COG2323	membrane
HR084_03080	COG0071	Belongs to the small heat shock protein (HSP20) family
HR084_03095	COG1309	transcriptional regulator
HR084_03105	COG0456	acetyltransferase
HR084_03115	COG0673	inositol 2-dehydrogenase activity
HR084_03120	COG1609	Transcriptional regulator
HR084_03125	COG2814	Major facilitator Superfamily
HR084_03130	COG1082	Xylose isomerase domain protein TIM barrel
HR084_03140	COG1113	amino acid transport
HR084_03145	COG2318	DinB family
HR084_03150	COG1846	Transcriptional regulator
HR084_03155	COG1033	growth of symbiont in host cell
HR084_03155	COG2409	Drug exporters of the RND superfamily
HR084_03160	COG0778	Nitroreductase
HR084_03165	COG1846	Transcriptional regulator
HR084_03170	COG2814	Major facilitator Superfamily
HR084_03175	COG0730	response to heat
HR084_03180	COG1802	Transcriptional regulator
HR084_03185	COG3858	chitin binding
HR084_03185	COG1388	LysM domain
HR084_03190	COG1819	glycosyl
HR084_03200	COG1785	Belongs to the alkaline phosphatase family
HR084_03205	COG5646	InterPro IPR014922
HR084_03215	COG0454	-acetyltransferase
HR084_03220	COG1078	dGTPase activity
HR084_03225	COG1388	LysM domain
HR084_03230	COG2814	Major facilitator Superfamily
HR084_03235	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HR084_03240	COG1447	Phosphotransferase system cellobiose-specific component IIA
HR084_03245	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HR084_03250	COG2723	6-phospho-beta-galactosidase activity
HR084_03255	COG2188	Transcriptional regulator
HR084_03260	COG1940	carbohydrate kinase activity
HR084_03265	COG1482	cell wall glycoprotein biosynthetic process
HR084_03270	COG4124	Belongs to the glycosyl hydrolase 26 family
HR084_03315	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HR084_03320	COG0802	atpase or kinase
HR084_03325	COG1214	PFAM Peptidase M22, glycoprotease
HR084_03330	COG0456	acetyltransferase
HR084_03335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HR084_03340	COG0488	(ABC) transporter
HR084_03345	COG0315	cyclic pyranopterin monophosphate synthase activity
HR084_03350	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HR084_03355	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HR084_03360	COG0805	protein transport
HR084_03370	COG1266	CAAX protease self-immunity
HR084_03380	COG0459	protein refolding
HR084_03385	COG1073	alpha beta
HR084_03390	COG0457	Tetratricopeptide repeat
HR084_03395	COG1063	alcohol dehydrogenase
HR084_03400	COG2211	Major facilitator Superfamily
HR084_03405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HR084_03410	COG1842	Phage shock protein A
HR084_03415	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HR084_03420	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HR084_03425	COG4260	virion core protein, lumpy skin disease virus
HR084_03435	COG2814	Major facilitator Superfamily
HR084_03440	COG1063	alcohol dehydrogenase
HR084_03445	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HR084_03450	COG0823	Involved in the tonB-independent uptake of proteins
HR084_03465	COG2267	carboxylic ester hydrolase activity
HR084_03475	COG2132	Multicopper oxidase
HR084_03480	COG1113	amino acid transport
HR084_03490	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HR084_03495	COG0714	Associated with various cellular activities
HR084_03500	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HR084_03505	COG1305	Transglutaminase-like
HR084_03510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HR084_03510	COG0519	Catalyzes the synthesis of GMP from XMP
HR084_03525	COG2252	PERMEase
HR084_03530	COG3064	Membrane
HR084_03540	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HR084_03550	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HR084_03555	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HR084_03560	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HR084_03565	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HR084_03570	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HR084_03575	COG0047	phosphoribosylformylglycinamidine synthase activity
HR084_03580	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HR084_03585	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HR084_03590	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HR084_03595	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HR084_03600	COG0138	bifunctional purine biosynthesis protein purh
HR084_03605	COG0151	Belongs to the GarS family
HR084_03610	COG1522	sequence-specific DNA binding
HR084_03615	COG0531	amino acid
HR084_03625	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HR084_03630	COG1470	cell adhesion involved in biofilm formation
HR084_03635	COG4496	protein, YerC YecD
HR084_03640	COG0069	glutamate synthase activity
HR084_03645	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HR084_03650	COG0210	DNA helicase
HR084_03655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HR084_03660	COG4851	CamS sex pheromone cAM373 precursor
HR084_03665	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HR084_03670	COG1285	pathogenesis
HR084_03675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HR084_03680	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HR084_03685	COG0154	amidase activity
HR084_03690	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HR084_03695	COG1309	transcriptional regulator
HR084_03700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HR084_03705	COG1597	lipid kinase activity
HR084_03710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HR084_03725	COG0210	DNA helicase
HR084_03765	COG5444	nuclease activity
HR084_03775	COG3586	endonuclease activity
HR084_03785	COG0457	Tetratricopeptide repeat
HR084_03795	COG0217	transcriptional regulatory protein
HR084_03805	COG1309	transcriptional regulator
HR084_03810	COG3631	Ketosteroid isomerase-related protein
HR084_03815	COG0702	epimerase
HR084_03830	COG3546	catalase activity
HR084_03835	COG0454	-acetyltransferase
HR084_03845	COG5578	integral membrane protein
HR084_03850	COG2972	Histidine kinase
HR084_03855	COG4753	response regulator
HR084_03855	COG2207	Transcriptional regulator
HR084_03860	COG1653	transport
HR084_03865	COG1175	transmembrane transport
HR084_03870	COG0395	ABC-type sugar transport system, permease component
HR084_03875	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HR084_03880	COG2207	Transcriptional regulator
HR084_03885	COG2755	lipolytic protein G-D-S-L family
HR084_03895	COG5578	integral membrane protein
HR084_03900	COG3401	FG-GAP repeat protein
HR084_03905	COG3401	FG-GAP repeat protein
HR084_03910	COG2755	lipolytic protein G-D-S-L family
HR084_03915	COG1874	Beta-galactosidase
HR084_03925	COG1653	transport
HR084_03930	COG4209	transmembrane transport
HR084_03935	COG0395	ABC-type sugar transport system, permease component
HR084_03940	COG1486	melibiose metabolic process
HR084_03945	COG2323	membrane
HR084_03950	COG2329	Antibiotic biosynthesis monooxygenase
HR084_03955	COG0346	lactoylglutathione lyase activity
HR084_03970	COG5583	Uncharacterized small protein (DUF2292)
HR084_03975	COG0670	Belongs to the BI1 family
HR084_03980	COG0697	spore germination
HR084_03985	COG1846	Transcriptional regulator
HR084_03990	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HR084_04000	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HR084_04000	COG2124	cytochrome p450
HR084_04005	COG1368	sulfuric ester hydrolase activity
HR084_04010	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HR084_04015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HR084_04020	COG1442	glycosyl transferase family 8
HR084_04025	COG1216	Glycosyl transferase, family 2
HR084_04030	COG1442	glycosyl transferase family 8
HR084_04035	COG2223	nitrite transmembrane transporter activity
HR084_04040	COG1011	Hydrolase
HR084_04045	COG0531	amino acid
HR084_04050	COG1012	belongs to the aldehyde dehydrogenase family
HR084_04055	COG0840	transmembrane signaling receptor activity
HR084_04060	COG0488	(ABC) transporter
HR084_04070	COG0789	Transcriptional regulator
HR084_04075	COG2814	Major facilitator Superfamily
HR084_04085	COG0488	(ABC) transporter
HR084_04090	COG0513	Belongs to the DEAD box helicase family
HR084_04095	COG0456	acetyltransferase
HR084_04100	COG2130	NADP-dependent
HR084_04105	COG2211	Major facilitator Superfamily
HR084_04110	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HR084_04115	COG1120	ATPase activity
HR084_04120	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HR084_04125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HR084_04130	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HR084_04145	COG3866	Pectate lyase
HR084_04150	COG0471	metal ion transport
HR084_04155	COG3290	protein histidine kinase activity
HR084_04160	COG4565	transcriptional regulatory protein
HR084_04165	COG3181	Tripartite tricarboxylate transporter family receptor
HR084_04170	COG2851	Citrate transporter
HR084_04175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HR084_04180	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HR084_04185	COG1254	Belongs to the acylphosphatase family
HR084_04190	COG2258	MOSC domain
HR084_04210	COG0024	Methionine aminopeptidase
HR084_04215	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HR084_04215	COG1263	PTS System
HR084_04220	COG1368	sulfuric ester hydrolase activity
HR084_04235	COG1115	amino acid carrier protein
HR084_04240	COG0531	amino acid
HR084_04255	COG0697	spore germination
HR084_04260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HR084_04260	COG1263	PTS System
HR084_04265	COG0366	Alpha amylase catalytic
HR084_04270	COG2188	Transcriptional regulator
HR084_04275	COG0778	Nitroreductase
HR084_04280	COG0737	Belongs to the 5'-nucleotidase family
HR084_04285	COG0693	protein deglycase activity
HR084_04290	COG2814	Major facilitator Superfamily
HR084_04295	COG4840	Belongs to the UPF0435 family
HR084_04300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HR084_04305	COG4980	gas vesicle protein
HR084_04310	COG1295	ribonuclease BN
HR084_04315	COG0477	Major facilitator Superfamily
HR084_04320	COG0387	Pfam Sodium calcium exchanger
HR084_04330	COG0668	transmembrane transport
HR084_04335	COG0535	radical SAM domain protein
HR084_04345	COG0726	polysaccharide deacetylase
HR084_04350	COG2084	Dehydrogenase
HR084_04355	COG0598	Magnesium transport protein CorA
HR084_04360	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HR084_04365	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HR084_04370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HR084_04385	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HR084_04390	COG0022	dehydrogenase e1 component
HR084_04395	COG0508	dehydrogenase complex catalyzes the overall conversion of
HR084_04400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HR084_04405	COG3284	Transcriptional regulator
HR084_04415	COG1742	UPF0060 membrane protein
HR084_04435	COG4842	Belongs to the WXG100 family
HR084_04440	COG1486	melibiose metabolic process
HR084_04445	COG1737	Transcriptional regulator
HR084_04450	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HR084_04450	COG1263	PTS System
HR084_04455	COG5434	Belongs to the glycosyl hydrolase 28 family
HR084_04460	COG1132	(ABC) transporter
HR084_04465	COG1132	(ABC) transporter
HR084_04470	COG2259	Doxx family
HR084_04475	COG2514	catechol 2,3-dioxygenase activity
HR084_04480	COG4585	Histidine kinase
HR084_04485	COG2197	response regulator
HR084_04490	COG1131	(ABC) transporter
HR084_04495	COG1511	domain protein
HR084_04495	COG0842	Transport permease protein
HR084_04500	COG0842	Transport permease protein
HR084_04505	COG1695	Transcriptional regulator
HR084_04510	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HR084_04515	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HR084_04520	COG2318	DinB family
HR084_04525	COG2814	Major facilitator Superfamily
HR084_04530	COG1846	Transcriptional regulator
HR084_04535	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HR084_04535	COG0392	lysyltransferase activity
HR084_04540	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HR084_04545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HR084_04550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HR084_04555	COG0384	phenazine biosynthesis protein PhzF
HR084_04560	COG0778	Nitroreductase
HR084_04575	COG1090	epimerase
HR084_04580	COG2137	regulation of response to DNA damage stimulus
HR084_04590	COG2814	Major facilitator Superfamily
HR084_04605	COG3103	Sh3 type 3 domain protein
HR084_04610	COG5658	integral membrane protein
HR084_04615	COG0596	Alpha beta hydrolase
HR084_04620	COG0463	Glycosyl transferase, family 2
HR084_04625	COG4485	Bacterial membrane protein, YfhO
HR084_04630	COG1988	membrane-bound metal-dependent
HR084_04635	COG1194	a g-specific adenine glycosylase
HR084_04645	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_04660	COG3557	Belongs to the UPF0374 family
HR084_04665	COG1132	(ABC) transporter
HR084_04670	COG4129	membrane
HR084_04675	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HR084_04680	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HR084_04685	COG0735	belongs to the Fur family
HR084_04795	COG4326	sporulation control protein
HR084_04805	COG5577	PFAM Coat F domain
HR084_04810	COG3340	Belongs to the peptidase S51 family
HR084_04815	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HR084_04820	COG0277	FAD linked oxidase domain protein
HR084_04830	COG0753	catalase activity
HR084_04835	COG1116	anion transmembrane transporter activity
HR084_04840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HR084_04845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HR084_04850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HR084_04860	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HR084_04870	COG1476	TRANSCRIPTIONal
HR084_04880	COG3382	B3 4 domain protein
HR084_04885	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HR084_04895	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HR084_04900	COG0789	Transcriptional regulator
HR084_04905	COG1664	Polymer-forming cytoskeletal
HR084_04910	COG1664	Polymer-forming cytoskeletal
HR084_04915	COG2766	serine protein kinase
HR084_04920	COG2718	Belongs to the UPF0229 family
HR084_04925	COG1846	Transcriptional regulator
HR084_04930	COG1566	PFAM secretion protein HlyD family protein
HR084_04935	COG2814	Major facilitator Superfamily
HR084_04940	COG0655	NAD(P)H dehydrogenase (quinone) activity
HR084_04960	COG1725	Transcriptional regulator
HR084_04965	COG1131	(ABC) transporter
HR084_04970	COG1131	(ABC) transporter
HR084_04975	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HR084_04980	COG1278	Cold shock
HR084_04985	COG1464	Belongs to the NlpA lipoprotein family
HR084_04990	COG3706	GGDEF domain
HR084_04995	COG1823	symporter activity
HR084_05015	COG5577	PFAM Coat F domain
HR084_05020	COG0737	Belongs to the 5'-nucleotidase family
HR084_05020	COG1525	nuclease
HR084_05020	COG4085	toxin activity
HR084_05025	COG3764	Sortase (surface protein transpeptidase)
HR084_05030	COG0564	pseudouridine synthase activity
HR084_05040	COG0517	IMP dehydrogenase activity
HR084_05045	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HR084_05050	COG3153	acetyltransferase
HR084_05050	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HR084_05055	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HR084_05060	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HR084_05065	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HR084_05070	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HR084_05075	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HR084_05080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HR084_05085	COG2203	Gaf domain
HR084_05085	COG4585	Histidine kinase
HR084_05090	COG2197	response regulator
HR084_05095	COG0431	NADPH-dependent FMN reductase
HR084_05110	COG1388	LysM domain
HR084_05110	COG0791	NLP P60 protein
HR084_05115	COG1959	2 iron, 2 sulfur cluster binding
HR084_05120	COG0668	transmembrane transport
HR084_05125	COG2719	SpoVR family
HR084_05130	COG1785	Belongs to the alkaline phosphatase family
HR084_05135	COG0791	NLP P60 protein
HR084_05135	COG1388	LysM domain
HR084_05140	COG0583	DNA-binding transcription factor activity
HR084_05145	COG0372	Belongs to the citrate synthase family
HR084_05150	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_05155	COG0531	amino acid
HR084_05160	COG0733	neurotransmitter:sodium symporter activity
HR084_05165	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HR084_05170	COG0456	acetyltransferase
HR084_05185	COG1595	DNA-templated transcription, initiation
HR084_05190	COG0667	Aldo Keto reductase
HR084_05195	COG0204	Acyl-transferase
HR084_05200	COG1253	flavin adenine dinucleotide binding
HR084_05205	COG0789	Transcriptional regulator
HR084_05210	COG0436	Aminotransferase
HR084_05215	COG1253	flavin adenine dinucleotide binding
HR084_05220	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HR084_05225	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HR084_05230	COG0584	glycerophosphoryl diester phosphodiesterase
HR084_05240	COG0668	transmembrane transport
HR084_05245	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HR084_05250	COG0726	polysaccharide deacetylase
HR084_05255	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HR084_05260	COG1757	Na H antiporter
HR084_05265	COG0589	response to stress
HR084_05275	COG1132	(ABC) transporter
HR084_05280	COG1132	(ABC) transporter
HR084_05285	COG0702	epimerase
HR084_05305	COG0189	ligase activity
HR084_05310	COG0189	ligase activity
HR084_05315	COG4399	Belongs to the UPF0754 family
HR084_05320	COG3679	Belongs to the UPF0342 family
HR084_05325	COG4335	DNA alkylation repair
HR084_05330	COG0561	phosphatase activity
HR084_05335	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HR084_05340	COG0475	glutathione-regulated potassium exporter activity
HR084_05345	COG0490	domain, Protein
HR084_05355	COG1024	Enoyl-CoA hydratase
HR084_05365	COG4152	abc transporter atp-binding protein
HR084_05370	COG1668	transmembrane transport
HR084_05375	COG0420	3'-5' exonuclease activity
HR084_05380	COG4717	serine-type aminopeptidase activity
HR084_05385	COG3481	metal-dependent phosphohydrolase, HD sub domain
HR084_05395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HR084_05425	COG1846	Transcriptional regulator
HR084_05430	COG4980	gas vesicle protein
HR084_05445	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HR084_05450	COG0537	adenosine 5'-monophosphoramidase activity
HR084_05455	COG1131	(ABC) transporter
HR084_05460	COG4473	ABC transporter
HR084_05470	COG1473	amidohydrolase
HR084_05475	COG3069	C4-dicarboxylate transmembrane transporter activity
HR084_05485	COG2329	Antibiotic biosynthesis monooxygenase
HR084_05490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HR084_05495	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HR084_05510	COG1309	transcriptional regulator
HR084_05515	COG1511	domain protein
HR084_05520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HR084_05525	COG4377	Putative membrane peptidase family (DUF2324)
HR084_05535	COG1363	Peptidase, m42
HR084_05540	COG4405	Protein conserved in bacteria
HR084_05545	COG1301	dicarboxylic acid transport
HR084_05555	COG1234	tRNA 3'-trailer cleavage
HR084_05560	COG0095	Lipoate-protein ligase
HR084_05565	COG0702	epimerase
HR084_05570	COG0318	PFAM AMP-dependent synthetase and ligase
HR084_05580	COG0501	Belongs to the peptidase M48B family
HR084_05585	COG1404	Belongs to the peptidase S8 family
HR084_05590	COG0456	acetyltransferase
HR084_05595	COG0604	alcohol dehydrogenase
HR084_05600	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HR084_05605	COG0406	alpha-ribazole phosphatase activity
HR084_05610	COG0183	Belongs to the thiolase family
HR084_05615	COG0318	PFAM AMP-dependent synthetase and ligase
HR084_05620	COG1268	BioY protein
HR084_05625	COG0840	transmembrane signaling receptor activity
HR084_05630	COG0723	plastoquinol--plastocyanin reductase activity
HR084_05630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HR084_05635	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_05645	COG4903	ComK protein
HR084_05650	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_05660	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HR084_05675	COG0398	Pfam SNARE associated Golgi protein
HR084_05680	COG0681	Belongs to the peptidase S26 family
HR084_05685	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HR084_05690	COG1846	Transcriptional regulator
HR084_05695	COG0738	Major facilitator superfamily
HR084_05700	COG0673	inositol 2-dehydrogenase activity
HR084_05705	COG0561	phosphatase activity
HR084_05710	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HR084_05715	COG1609	Transcriptional regulator
HR084_05720	COG3180	Ammonia monooxygenase
HR084_05725	COG0477	Major facilitator Superfamily
HR084_05725	COG2814	Major facilitator Superfamily
HR084_05730	COG4533	DNA binding
HR084_05740	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HR084_05745	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HR084_05750	COG1074	ATP-dependent DNA helicase activity
HR084_05755	COG0420	3'-5' exonuclease activity
HR084_05760	COG0419	ATPase involved in DNA repair
HR084_05765	COG1403	HNH endonuclease
HR084_05805	COG5337	Spore coat protein CotH
HR084_05810	COG0179	Fumarylacetoacetate (FAA) hydrolase
HR084_05820	COG1404	Belongs to the peptidase S8 family
HR084_05830	COG0367	asparagine synthase
HR084_05835	COG2318	DinB family
HR084_05840	COG1562	ergosterol biosynthetic process
HR084_05845	COG0534	Mate efflux family protein
HR084_05850	COG2207	Transcriptional regulator
HR084_05850	COG1917	Cupin 2, conserved barrel domain protein
HR084_05855	COG1609	Transcriptional regulator
HR084_05860	COG0673	inositol 2-dehydrogenase activity
HR084_05865	COG2318	DinB family
HR084_05875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HR084_05880	COG1357	PFAM Pentapeptide repeats (8 copies)
HR084_05885	COG2267	carboxylic ester hydrolase activity
HR084_05890	COG0529	Catalyzes the synthesis of activated sulfate
HR084_05895	COG2046	Belongs to the sulfate adenylyltransferase family
HR084_05900	COG0175	sulfate reduction
HR084_05905	COG2045	Belongs to the ComB family
HR084_05910	COG1809	phosphosulfolactate synthase activity
HR084_05915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HR084_05920	COG4948	Mandelate Racemase Muconate Lactonizing
HR084_05925	COG2814	Major facilitator Superfamily
HR084_05930	COG0454	-acetyltransferase
HR084_05935	COG2153	protein acetylation
HR084_05940	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HR084_05940	COG0646	methionine synthase
HR084_05945	COG1666	GTP binding
HR084_05950	COG2996	Protein conserved in bacteria
HR084_05970	COG1695	Transcriptional regulator
HR084_05985	COG3227	Zinc metalloprotease (Elastase)
HR084_05990	COG1307	EDD domain protein, DegV family
HR084_05995	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HR084_06015	COG0561	phosphatase activity
HR084_06020	COG1073	alpha beta
HR084_06025	COG2151	metal-sulfur cluster biosynthetic enzyme
HR084_06035	COG0277	FAD linked oxidase domain protein
HR084_06040	COG2271	Major facilitator Superfamily
HR084_06045	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HR084_06050	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HR084_06060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HR084_06065	COG0505	Belongs to the CarA family
HR084_06070	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HR084_06075	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HR084_06090	COG2267	carboxylic ester hydrolase activity
HR084_06100	COG1744	ABC transporter substrate-binding protein PnrA-like
HR084_06115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HR084_06120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HR084_06125	COG5504	Zn-dependent protease
HR084_06130	COG0444	Belongs to the ABC transporter superfamily
HR084_06135	COG4608	Belongs to the ABC transporter superfamily
HR084_06145	COG0601	transmembrane transport
HR084_06150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HR084_06160	COG0180	Tryptophanyl-tRNA synthetase
HR084_06165	COG4166	transmembrane transport
HR084_06170	COG0601	transmembrane transport
HR084_06175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HR084_06180	COG0444	Belongs to the ABC transporter superfamily
HR084_06185	COG4608	Belongs to the ABC transporter superfamily
HR084_06190	COG2814	Major facilitator Superfamily
HR084_06195	COG0456	acetyltransferase
HR084_06200	COG1393	Belongs to the ArsC family
HR084_06205	COG0861	Integral membrane protein TerC family
HR084_06215	COG4862	establishment of competence for transformation
HR084_06225	COG4469	Competence protein
HR084_06230	COG1164	Oligoendopeptidase f
HR084_06245	COG2346	COG2346, Truncated hemoglobins
HR084_06250	COG0741	lytic transglycosylase activity
HR084_06255	COG4116	CYTH
HR084_06265	COG2357	RelA SpoT domain protein
HR084_06270	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HR084_06275	COG0564	pseudouridine synthase activity
HR084_06280	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HR084_06285	COG0475	glutathione-regulated potassium exporter activity
HR084_06285	COG0569	domain protein
HR084_06290	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HR084_06295	COG0352	thiamine-phosphate diphosphorylase activity
HR084_06300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HR084_06305	COG2104	thiamine diphosphate biosynthetic process
HR084_06310	COG2022	thiamine diphosphate biosynthetic process
HR084_06315	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HR084_06320	COG0351	phosphomethylpyrimidine kinase
HR084_06325	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HR084_06380	COG0210	DNA helicase
HR084_06390	COG2153	protein acetylation
HR084_06395	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HR084_06400	COG2382	esterase
HR084_06405	COG0626	cystathionine gamma-synthase activity
HR084_06410	COG0626	cystathionine gamma-synthase activity
HR084_06415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HR084_06420	COG5505	Protein of unknown function (DUF819)
HR084_06440	COG5444	nuclease activity
HR084_06460	COG0457	Tetratricopeptide repeat
HR084_06465	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HR084_06470	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_06480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HR084_06480	COG3711	transcriptional antiterminator
HR084_06485	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HR084_06485	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HR084_06485	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HR084_06490	COG1482	cell wall glycoprotein biosynthetic process
HR084_06500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HR084_06510	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HR084_06525	COG0109	protoheme IX farnesyltransferase activity
HR084_06535	COG0726	polysaccharide deacetylase
HR084_06550	COG5504	Zn-dependent protease
HR084_06555	COG2205	protein histidine kinase activity
HR084_06565	COG3383	formate dehydrogenase (NAD+) activity
HR084_06570	COG2427	Protein of unknown function (DUF1641)
HR084_06580	COG1051	belongs to the nudix hydrolase family
HR084_06590	COG2124	cytochrome p450
HR084_06595	COG1819	glycosyl
HR084_06605	COG1587	Uroporphyrinogen-III synthase
HR084_06610	COG0390	transport system, permease component
HR084_06615	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HR084_06620	COG0697	spore germination
HR084_06625	COG4297	protein containing double-stranded beta helix domain
HR084_06635	COG1252	NADH dehydrogenase
HR084_06640	COG1904	glucuronate isomerase
HR084_06645	COG2211	Major facilitator Superfamily
HR084_06650	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HR084_06655	COG1063	alcohol dehydrogenase
HR084_06660	COG1312	Catalyzes the dehydration of D-mannonate
HR084_06665	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_06670	COG2271	Major facilitator Superfamily
HR084_06675	COG1609	Transcriptional regulator
HR084_06680	COG0246	Mannitol dehydrogenase
HR084_06685	COG2721	sulfolactate sulfo-lyase activity
HR084_06690	COG0730	response to heat
HR084_06695	COG2318	DinB family
HR084_06700	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HR084_06705	COG0457	Tetratricopeptide repeat
HR084_06715	COG2350	Protein conserved in bacteria
HR084_06720	COG5632	N-Acetylmuramoyl-L-alanine amidase
HR084_06720	COG1388	LysM domain
HR084_06720	COG3409	Peptidoglycan-binding domain 1 protein
HR084_06730	COG4195	phage-related replication protein
HR084_06735	COG3546	catalase activity
HR084_06740	COG2856	Zn peptidase
HR084_06745	COG1396	sequence-specific DNA binding
HR084_06755	COG1522	sequence-specific DNA binding
HR084_06760	COG1484	DNA-dependent DNA replication
HR084_06780	COG1595	DNA-templated transcription, initiation
HR084_06785	COG5484	DNA packaging
HR084_06785	COG3728	DNA packaging
HR084_06790	COG1783	phage Terminase large subunit
HR084_06795	COG5518	Phage portal protein
HR084_06800	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HR084_06805	COG4653	Phage capsid family
HR084_06855	COG5412	phage tail tape measure protein
HR084_06855	COG3953	SLT domain
HR084_06855	COG5412	phage tail tape measure protein
HR084_06855	COG3953	SLT domain
HR084_06860	COG1652	LysM domain
HR084_06865	COG4193	domain, Protein
HR084_06875	COG3628	GPW Gp25 family protein
HR084_06880	COG3299	homolog of phage Mu protein gp47
HR084_06885	COG3778	Protein conserved in bacteria
HR084_06925	COG5632	N-Acetylmuramoyl-L-alanine amidase
HR084_06925	COG3409	Peptidoglycan-binding domain 1 protein
HR084_06945	COG0306	phosphate transporter
HR084_06950	COG1392	Phosphate transport regulator
HR084_06955	COG0531	amino acid
HR084_06960	COG0346	lactoylglutathione lyase activity
HR084_06965	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HR084_06970	COG0463	Glycosyl transferase, family 2
HR084_06975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HR084_06980	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HR084_06985	COG2362	D-Aminopeptidase
HR084_06990	COG0601	transmembrane transport
HR084_06995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HR084_07000	COG0444	Belongs to the ABC transporter superfamily
HR084_07005	COG4166	transmembrane transport
HR084_07010	COG1619	proteins homologs of microcin C7 resistance protein MccF
HR084_07015	COG4948	Mandelate Racemase Muconate Lactonizing
HR084_07020	COG0791	NLP P60 protein
HR084_07025	COG4608	Belongs to the ABC transporter superfamily
HR084_07030	COG2706	6-phosphogluconolactonase activity
HR084_07035	COG1834	amidinotransferase
HR084_07040	COG1607	acyl-coa hydrolase
HR084_07045	COG1017	nitric oxide dioxygenase activity
HR084_07045	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HR084_07055	COG2323	membrane
HR084_07060	COG2318	DinB family
HR084_07065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HR084_07070	COG2076	Multidrug Resistance protein
HR084_07075	COG2076	Multidrug Resistance protein
HR084_07080	COG0788	formyltetrahydrofolate deformylase activity
HR084_07085	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HR084_07090	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HR084_07095	COG1764	response to oxidative stress
HR084_07100	COG1846	Transcriptional regulator
HR084_07105	COG1764	response to oxidative stress
HR084_07115	COG0590	tRNA wobble adenosine to inosine editing
HR084_07120	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HR084_07125	COG1404	Belongs to the peptidase S8 family
HR084_07130	COG1366	Belongs to the anti-sigma-factor antagonist family
HR084_07135	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HR084_07140	COG1122	ATPase activity
HR084_07145	COG4721	ABC-type cobalt transport system, permease component
HR084_07155	COG0745	RESPONSE REGULATOR receiver
HR084_07160	COG5002	protein histidine kinase activity
HR084_07160	COG3850	Histidine kinase
HR084_07165	COG3212	peptidase
HR084_07170	COG3212	peptidase
HR084_07180	COG2239	Acts as a magnesium transporter
HR084_07185	COG0789	Transcriptional regulator
HR084_07200	COG1846	Transcriptional regulator
HR084_07205	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HR084_07210	COG0726	polysaccharide deacetylase
HR084_07215	COG1408	metallophosphoesterase
HR084_07225	COG0463	Glycosyl transferase, family 2
HR084_07230	COG3285	dna ligase
HR084_07230	COG1793	dna ligase
HR084_07235	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HR084_07240	COG5001	Diguanylate cyclase
HR084_07240	COG3300	MHYT domain
HR084_07245	COG0586	Pfam SNARE associated Golgi protein
HR084_07250	COG0861	Integral membrane protein TerC family
HR084_07255	COG1191	sigma factor activity
HR084_07275	COG0501	Belongs to the peptidase M48B family
HR084_07280	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HR084_07295	COG3594	Acyltransferase
HR084_07300	COG5002	protein histidine kinase activity
HR084_07305	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HR084_07315	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HR084_07320	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HR084_07325	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HR084_07330	COG0436	Aminotransferase
HR084_07335	COG1850	ribulose-bisphosphate carboxylase activity
HR084_07340	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HR084_07345	COG0235	Class ii aldolase
HR084_07350	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HR084_07355	COG3339	Conserved Protein
HR084_07370	COG3852	Histidine kinase
HR084_07375	COG1846	Transcriptional regulator
HR084_07380	COG1360	Flagellar Motor Protein
HR084_07385	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HR084_07390	COG0542	response to heat
HR084_07395	COG3949	Membrane
HR084_07400	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HR084_07405	COG0720	synthase
HR084_07410	COG0602	queuosine metabolic process
HR084_07415	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HR084_07420	COG1733	regulation of RNA biosynthetic process
HR084_07425	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_07430	COG1388	LysM domain
HR084_07430	COG4641	Protein conserved in bacteria
HR084_07435	COG1388	LysM domain
HR084_07450	COG4873	Protein conserved in bacteria
HR084_07460	COG3773	Cell wall hydrolase
HR084_07465	COG2244	polysaccharide biosynthetic process
HR084_07470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HR084_07475	COG2217	Heavy metal translocating P-type atpase
HR084_07485	COG0006	proline dipeptidase activity
HR084_07490	COG1609	Transcriptional regulator
HR084_07495	COG3711	transcriptional antiterminator
HR084_07500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HR084_07500	COG1263	PTS System
HR084_07500	COG2190	(PTS) system
HR084_07505	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HR084_07510	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HR084_07520	COG1533	DNA photolyase activity
HR084_07525	COG0456	acetyltransferase
HR084_07530	COG0840	transmembrane signaling receptor activity
HR084_07535	COG2084	Dehydrogenase
HR084_07540	COG2340	Cysteine-rich secretory protein family
HR084_07545	COG0768	penicillin binding
HR084_07550	COG4191	Histidine kinase
HR084_07555	COG0436	Aminotransferase
HR084_07565	COG0784	Response regulator, receiver
HR084_07565	COG0835	chemotaxis
HR084_07575	COG2814	Major facilitator Superfamily
HR084_07580	COG1376	ErfK ybiS ycfS ynhG family protein
HR084_07585	COG1408	metallophosphoesterase
HR084_07590	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_07595	COG2200	EAL domain
HR084_07600	COG4703	Protein of unknown function (DUF1797)
HR084_07605	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HR084_07615	COG0517	IMP dehydrogenase activity
HR084_07620	COG0583	DNA-binding transcription factor activity
HR084_07625	COG0716	FMN binding
HR084_07635	COG0716	FMN binding
HR084_07640	COG2171	N-acyltransferase activity
HR084_07645	COG1473	amidohydrolase
HR084_07655	COG0668	transmembrane transport
HR084_07660	COG0450	alkyl hydroperoxide reductase
HR084_07665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HR084_07680	COG0746	molybdenum cofactor guanylyltransferase activity
HR084_07685	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HR084_07690	COG0303	'Molybdopterin
HR084_07695	COG1763	Mo-molybdopterin cofactor biosynthetic process
HR084_07700	COG0314	molybdopterin synthase activity
HR084_07705	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HR084_07710	COG1132	(ABC) transporter
HR084_07715	COG1132	(ABC) transporter
HR084_07725	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HR084_07730	COG1136	(ABC) transporter
HR084_07735	COG0577	efflux transmembrane transporter activity
HR084_07740	COG1349	DNA-binding transcription factor activity
HR084_07745	COG1105	Belongs to the carbohydrate kinase PfkB family
HR084_07750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HR084_07750	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HR084_07750	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HR084_07755	COG0681	Belongs to the peptidase S26 family
HR084_07765	COG0488	(ABC) transporter
HR084_07770	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HR084_07775	COG2309	aminopeptidase activity
HR084_07785	COG1077	Cell shape determining protein MreB Mrl
HR084_07790	COG2002	toxin-antitoxin pair type II binding
HR084_07795	COG3852	Histidine kinase
HR084_07800	COG2105	PFAM AIG2 family protein
HR084_07800	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HR084_07805	COG0569	domain protein
HR084_07810	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HR084_07815	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HR084_07825	COG0561	phosphatase activity
HR084_07830	COG0242	peptide deformylase activity
HR084_07840	COG0497	DNA recombination
HR084_07845	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HR084_07850	COG0022	dehydrogenase e1 component
HR084_07855	COG0508	dehydrogenase complex catalyzes the overall conversion of
HR084_07860	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HR084_07865	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HR084_07875	COG1982	Orn Lys Arg decarboxylase major
HR084_07880	COG4476	Belongs to the UPF0223 family
HR084_07885	COG4493	Belongs to the UPF0637 family
HR084_07895	COG0483	inositol monophosphate 1-phosphatase activity
HR084_07905	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HR084_07925	COG1595	DNA-templated transcription, initiation
HR084_07955	COG4896	Protein conserved in bacteria
HR084_07965	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HR084_07970	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HR084_07975	COG2066	Belongs to the glutaminase family
HR084_07980	COG4838	Belongs to the UPF0358 family
HR084_07985	COG0772	Belongs to the SEDS family
HR084_07990	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HR084_07995	COG1612	heme a metabolic process
HR084_08000	COG0109	protoheme IX farnesyltransferase activity
HR084_08005	COG2010	Cytochrome c
HR084_08005	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HR084_08010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HR084_08015	COG1845	cytochrome c oxidase, subunit III
HR084_08020	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HR084_08025	COG3336	cytochrome c oxidase
HR084_08035	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HR084_08040	COG2340	Cysteine-rich secretory protein family
HR084_08055	COG3679	Belongs to the UPF0342 family
HR084_08060	COG4471	UPF0298 protein
HR084_08065	COG0742	ribosomal rna small subunit methyltransferase
HR084_08070	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HR084_08075	COG3314	Sporulation integral membrane protein YlbJ
HR084_08080	COG1752	Esterase of the alpha-beta hydrolase superfamily
HR084_08085	COG3480	Lon protease (S16) C-terminal proteolytic domain
HR084_08090	COG1323	Belongs to the UPF0348 family
HR084_08100	COG1399	metal-binding, possibly nucleic acid-binding protein
HR084_08115	COG0454	-acetyltransferase
HR084_08120	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HR084_08125	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HR084_08130	COG2001	Belongs to the MraZ family
HR084_08135	COG0275	rRNA processing
HR084_08140	COG4839	cell division protein FtsL
HR084_08150	COG0768	penicillin binding
HR084_08155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HR084_08160	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HR084_08165	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HR084_08170	COG0772	Belongs to the SEDS family
HR084_08175	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HR084_08180	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HR084_08185	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HR084_08190	COG3879	Bacterial protein of unknown function (DUF881)
HR084_08195	COG3879	Bacterial protein of unknown function (DUF881)
HR084_08200	COG3856	small basic protein
HR084_08205	COG0849	cell division
HR084_08210	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HR084_08230	COG4412	M6 family metalloprotease domain protein
HR084_08230	COG1404	Belongs to the peptidase S8 family
HR084_08240	COG1191	sigma factor activity
HR084_08245	COG1191	sigma factor activity
HR084_08250	COG1119	ATPase activity
HR084_08255	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HR084_08260	COG1873	PFAM PRC-barrel domain
HR084_08270	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HR084_08275	COG1799	cell septum assembly
HR084_08280	COG0762	integral membrane protein
HR084_08285	COG2302	S4 RNA-binding domain
HR084_08290	COG3599	regulation of cell shape
HR084_08295	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HR084_08300	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HR084_08305	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HR084_08310	COG0564	pseudouridine synthase activity
HR084_08315	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HR084_08320	COG2233	PERMEase
HR084_08325	COG0540	Belongs to the ATCase OTCase family
HR084_08330	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HR084_08335	COG0505	Belongs to the CarA family
HR084_08340	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HR084_08345	COG0543	2 iron, 2 sulfur cluster binding
HR084_08350	COG0167	dihydroorotate dehydrogenase activity
HR084_08355	COG0284	orotidine-5'-phosphate decarboxylase activity
HR084_08360	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HR084_08365	COG0175	sulfate reduction
HR084_08370	COG0306	phosphate transporter
HR084_08375	COG2046	Belongs to the sulfate adenylyltransferase family
HR084_08380	COG0529	Catalyzes the synthesis of activated sulfate
HR084_08385	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HR084_08390	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HR084_08395	COG1648	precorrin-2 dehydrogenase activity
HR084_08400	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HR084_08405	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HR084_08410	COG1561	YicC-like family, N-terminal region
HR084_08420	COG0194	GDP metabolic process
HR084_08425	COG1758	RNA polymerase activity
HR084_08430	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HR084_08435	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HR084_08440	COG0242	peptide deformylase activity
HR084_08445	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HR084_08450	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HR084_08450	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HR084_08455	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HR084_08460	COG0631	protein serine/threonine phosphatase activity
HR084_08465	COG0515	serine threonine protein kinase
HR084_08465	COG2815	serine threonine protein kinase
HR084_08470	COG1162	GTPase activity
HR084_08475	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HR084_08480	COG1564	THIamine pyrophosphokinase
HR084_08490	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HR084_08495	COG1302	Protein conserved in bacteria
HR084_08500	COG1461	Dihydroxyacetone kinase
HR084_08505	COG1760	l-serine dehydratase
HR084_08510	COG1760	l-serine dehydratase
HR084_08515	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HR084_08520	COG1349	DNA-binding transcription factor activity
HR084_08520	COG2050	protein possibly involved in aromatic compounds catabolism
HR084_08525	COG0416	fatty acid biosynthetic process
HR084_08530	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HR084_08535	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_08545	COG0571	ribonuclease III activity
HR084_08550	COG1196	nuclear chromosome segregation
HR084_08555	COG0552	protein localization to endoplasmic reticulum
HR084_08565	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HR084_08570	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HR084_08575	COG0228	four-way junction DNA binding
HR084_08580	COG1837	Belongs to the UPF0109 family
HR084_08590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HR084_08595	COG0336	Belongs to the RNA methyltransferase TrmD family
HR084_08600	COG0335	large ribosomal subunit rRNA binding
HR084_08605	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HR084_08610	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HR084_08620	COG2257	FlhB HrpN YscU SpaS Family
HR084_08625	COG0045	succinate-CoA ligase (ADP-forming) activity
HR084_08630	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HR084_08635	COG0758	DNA mediated transformation
HR084_08640	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HR084_08645	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HR084_08650	COG4974	Belongs to the 'phage' integrase family
HR084_08655	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HR084_08660	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HR084_08665	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HR084_08670	COG1815	bacterial-type flagellum-dependent cell motility
HR084_08675	COG1558	bacterial-type flagellum-dependent cell motility
HR084_08680	COG1677	Flagellar hook-basal body complex protein FliE
HR084_08685	COG1766	The M ring may be actively involved in energy transduction
HR084_08690	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HR084_08695	COG1317	bacterial-type flagellum organization
HR084_08700	COG1157	protein secretion by the type III secretion system
HR084_08705	COG2882	bacterial-type flagellum organization
HR084_08710	COG3334	PFAM MgtE intracellular
HR084_08715	COG3144	bacterial-type flagellum assembly
HR084_08720	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HR084_08725	COG4786	Flagellar basal body rod
HR084_08730	COG1582	Flagellar protein (FlbD)
HR084_08735	COG1580	Controls the rotational direction of flagella during chemotaxis
HR084_08740	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HR084_08745	COG1776	CheC inhibitor of MCP methylation
HR084_08745	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HR084_08750	COG2201	protein-glutamate methylesterase activity
HR084_08755	COG3190	flagellar
HR084_08760	COG1338	Plays a role in the flagellum-specific transport system
HR084_08765	COG1987	bacterial-type flagellum assembly
HR084_08770	COG1684	flagellar biosynthetic protein fliR
HR084_08775	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HR084_08780	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HR084_08785	COG1419	protein localization to endoplasmic reticulum
HR084_08790	COG0455	bacterial-type flagellum organization
HR084_08795	COG2201	protein-glutamate methylesterase activity
HR084_08800	COG2198	Histidine kinase
HR084_08800	COG0643	Histidine kinase
HR084_08805	COG0835	chemotaxis
HR084_08810	COG1776	CheC inhibitor of MCP methylation
HR084_08815	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HR084_08820	COG1191	sigma factor activity
HR084_08830	COG0052	Belongs to the universal ribosomal protein uS2 family
HR084_08835	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HR084_08840	COG0528	UMP kinase activity
HR084_08845	COG0233	cytoplasmic translational termination
HR084_08850	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HR084_08855	COG4589	Belongs to the CDS family
HR084_08860	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HR084_08865	COG0750	zinc metalloprotease
HR084_08870	COG0442	prolyl-tRNA aminoacylation
HR084_08875	COG2176	DNA-directed DNA polymerase activity
HR084_08880	COG0779	Required for maturation of 30S ribosomal subunits
HR084_08885	COG0195	Participates in both transcription termination and antitermination
HR084_08890	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HR084_08895	COG1358	cellular component organization or biogenesis
HR084_08900	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HR084_08905	COG1550	Protein conserved in bacteria
HR084_08910	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HR084_08915	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HR084_08920	COG0196	riboflavin kinase activity
HR084_08925	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HR084_08930	COG1185	polyribonucleotide nucleotidyltransferase activity
HR084_08935	COG0726	polysaccharide deacetylase
HR084_08940	COG0612	Peptidase, M16
HR084_08945	COG1873	PFAM PRC-barrel domain
HR084_08950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HR084_08955	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HR084_08960	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HR084_08965	COG0527	aspartate kinase activity
HR084_08970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HR084_08975	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HR084_08980	COG0740	serine-type endopeptidase activity
HR084_08990	COG4980	gas vesicle protein
HR084_08990	COG1674	ftsk spoiiie
HR084_08995	COG2188	Transcriptional regulator
HR084_09000	COG2814	Major facilitator Superfamily
HR084_09005	COG0612	Peptidase, M16
HR084_09010	COG0612	Peptidase, M16
HR084_09015	COG0300	oxidoreductase activity
HR084_09030	COG1426	Protein conserved in bacteria
HR084_09035	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HR084_09040	COG1058	Belongs to the CinA family
HR084_09040	COG1546	Belongs to the CinA family
HR084_09045	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HR084_09050	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HR084_09055	COG1418	mRNA catabolic process
HR084_09060	COG1692	metallophosphoesterase
HR084_09065	COG2359	stage V sporulation protein S
HR084_09070	COG1063	alcohol dehydrogenase
HR084_09075	COG0156	8-amino-7-oxononanoate synthase activity
HR084_09080	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HR084_09085	COG4550	Control of competence regulator ComK, YlbF/YmcA
HR084_09095	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HR084_09100	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HR084_09115	COG3226	Transcriptional regulator
HR084_09120	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HR084_09130	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HR084_09135	COG3321	synthase
HR084_09140	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HR084_09140	COG2070	2-Nitropropane dioxygenase
HR084_09145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HR084_09150	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HR084_09155	COG3425	synthase
HR084_09160	COG1024	Enoyl-CoA hydratase
HR084_09165	COG1024	Enoyl-CoA hydratase
HR084_09170	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_09170	COG0300	oxidoreductase activity
HR084_09170	COG0318	PFAM AMP-dependent synthetase and ligase
HR084_09170	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HR084_09170	COG3321	synthase
HR084_09175	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HR084_09175	COG0300	oxidoreductase activity
HR084_09175	COG3321	synthase
HR084_09175	COG4221	oxidoreductase activity
HR084_09180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HR084_09180	COG3321	synthase
HR084_09180	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_09180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HR084_09180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HR084_09185	COG3321	synthase
HR084_09185	COG4221	oxidoreductase activity
HR084_09185	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_09185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HR084_09190	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HR084_09190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HR084_09190	COG3321	synthase
HR084_09190	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HR084_09195	COG2124	cytochrome p450
HR084_09205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HR084_09210	COG1404	Belongs to the peptidase S8 family
HR084_09220	COG4195	phage-related replication protein
HR084_09225	COG1764	response to oxidative stress
HR084_09230	COG2076	Multidrug Resistance protein
HR084_09235	COG2076	Multidrug Resistance protein
HR084_09250	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HR084_09255	COG1923	regulation of RNA biosynthetic process
HR084_09270	COG1780	Probably involved in ribonucleotide reductase function
HR084_09275	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HR084_09280	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HR084_09285	COG4112	unkown
HR084_09290	COG0860	N-Acetylmuramoyl-L-alanine amidase
HR084_09295	COG0464	growth
HR084_09300	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HR084_09305	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HR084_09310	COG0789	Transcriptional regulator
HR084_09315	COG0174	glutamine synthetase
HR084_09350	COG1598	PFAM Uncharacterised protein family UPF0150
HR084_09435	COG0463	Glycosyl transferase, family 2
HR084_09450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HR084_09465	COG3655	Transcriptional regulator
HR084_09480	COG0135	phosphoribosylanthranilate isomerase activity
HR084_09495	COG2211	Major facilitator Superfamily
HR084_09500	COG3507	Belongs to the glycosyl hydrolase 43 family
HR084_09505	COG1940	carbohydrate kinase activity
HR084_09510	COG2115	Belongs to the xylose isomerase family
HR084_09515	COG1070	Carbohydrate kinase
HR084_09520	COG1525	nuclease
HR084_09525	COG2814	Major facilitator Superfamily
HR084_09530	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HR084_09540	COG0756	dUTP diphosphatase activity
HR084_09580	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HR084_09590	COG3832	glyoxalase III activity
HR084_09605	COG0697	spore germination
HR084_09610	COG0531	amino acid
HR084_09640	COG4195	phage-related replication protein
HR084_09650	COG0346	lactoylglutathione lyase activity
HR084_09655	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HR084_09660	COG1388	LysM domain
HR084_09665	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HR084_09670	COG4224	UPF0291 protein
HR084_09675	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HR084_09685	COG3763	UPF0154 protein
HR084_09695	COG0785	Cytochrome C biogenesis protein
HR084_09700	COG2201	protein-glutamate methylesterase activity
HR084_09705	COG4846	Membrane protein involved in cytochrome C biogenesis
HR084_09715	COG0071	Belongs to the small heat shock protein (HSP20) family
HR084_09730	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HR084_09735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HR084_09755	COG0824	Thioesterase
HR084_09765	COG4841	protein insertion into membrane
HR084_09770	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HR084_09775	COG1832	CoA-binding protein
HR084_09780	COG0187	DNA topoisomerase II activity
HR084_09785	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HR084_09795	COG1115	amino acid carrier protein
HR084_09800	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HR084_09810	COG5520	Belongs to the glycosyl hydrolase 30 family
HR084_09815	COG3507	Belongs to the glycosyl hydrolase 43 family
HR084_09820	COG2246	polysaccharide biosynthetic process
HR084_09825	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HR084_09830	COG0586	Pfam SNARE associated Golgi protein
HR084_09835	COG2404	hydrolase activity, acting on ester bonds
HR084_09840	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HR084_09845	COG1024	Enoyl-CoA hydratase
HR084_09850	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HR084_09855	COG0511	ligase activity, forming carbon-carbon bonds
HR084_09860	COG0439	Biotin carboxylase
HR084_09865	COG0318	PFAM AMP-dependent synthetase and ligase
HR084_09870	COG1960	acyl-CoA dehydrogenase activity
HR084_09885	COG1649	PFAM Uncharacterised BCR, COG1649
HR084_09895	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HR084_09895	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HR084_09900	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HR084_09905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HR084_09910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HR084_09915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HR084_09920	COG2027	D-alanyl-D-alanine carboxypeptidase
HR084_09925	COG2017	converts alpha-aldose to the beta-anomer
HR084_09930	COG0534	Mate efflux family protein
HR084_09945	COG0582	viral genome integration into host DNA
HR084_09950	COG0166	Belongs to the GPI family
HR084_09955	COG0405	Gamma-glutamyltransferase
HR084_09960	COG0583	DNA-binding transcription factor activity
HR084_09965	COG0604	alcohol dehydrogenase
HR084_09970	COG0493	'glutamate synthase
HR084_09975	COG0067	glutamate synthase
HR084_09975	COG0069	glutamate synthase activity
HR084_09975	COG0070	glutamate synthase
HR084_09980	COG0583	DNA-binding transcription factor activity
HR084_09985	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HR084_09990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HR084_10000	COG0300	oxidoreductase activity
HR084_10005	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HR084_10015	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HR084_10035	COG2814	Major facilitator Superfamily
HR084_10040	COG1070	Carbohydrate kinase
HR084_10045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HR084_10050	COG0243	molybdopterin cofactor binding
HR084_10080	COG5278	phosphoserine phosphatase activity
HR084_10080	COG0840	transmembrane signaling receptor activity
HR084_10085	COG2368	4-hydroxyphenylacetate
HR084_10090	COG4305	rare lipoprotein A
HR084_10095	COG3619	membrane
HR084_10100	COG3866	Pectate lyase
HR084_10105	COG2135	peptidase activity
HR084_10125	COG0456	acetyltransferase
HR084_10145	COG2720	vancomycin resistance protein
HR084_10160	COG3739	integral membrane protein
HR084_10165	COG0583	DNA-binding transcription factor activity
HR084_10170	COG0697	spore germination
HR084_10180	COG0693	protein deglycase activity
HR084_10185	COG2367	Beta-lactamase
HR084_10200	COG3848	Pyruvate phosphate dikinase
HR084_10200	COG0574	Belongs to the PEP-utilizing enzyme family
HR084_10205	COG0726	polysaccharide deacetylase
HR084_10210	COG2314	TM2 domain
HR084_10215	COG1396	sequence-specific DNA binding
HR084_10335	COG0457	Tetratricopeptide repeat
HR084_10375	COG5444	nuclease activity
HR084_10380	COG4282	regulation of fungal-type cell wall biogenesis
HR084_10385	COG1231	oxidoreductase activity
HR084_10390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HR084_10395	COG0662	Cupin 2, conserved barrel domain protein
HR084_10395	COG2207	Transcriptional regulator
HR084_10400	COG0456	acetyltransferase
HR084_10405	COG1309	transcriptional regulator
HR084_10410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HR084_10415	COG3708	Transcriptional regulator
HR084_10420	COG2378	regulation of single-species biofilm formation
HR084_10430	COG0640	Transcriptional regulator
HR084_10435	COG0741	lytic transglycosylase activity
HR084_10440	COG2322	membrane
HR084_10455	COG1619	proteins homologs of microcin C7 resistance protein MccF
HR084_10460	COG3239	Fatty acid desaturase
HR084_10465	COG4585	Histidine kinase
HR084_10470	COG2197	response regulator
HR084_10475	COG1388	LysM domain
HR084_10475	COG3584	3D domain protein
HR084_10480	COG0514	ATP-dependent DNA helicase (RecQ)
HR084_10490	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HR084_10495	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HR084_10510	COG0071	Belongs to the small heat shock protein (HSP20) family
HR084_10535	COG1012	belongs to the aldehyde dehydrogenase family
HR084_10540	COG1657	PFAM Prenyltransferase squalene oxidase
HR084_10545	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HR084_10550	COG0733	neurotransmitter:sodium symporter activity
HR084_10555	COG0385	Bile acid
HR084_10560	COG0508	dehydrogenase complex catalyzes the overall conversion of
HR084_10565	COG0567	Dehydrogenase, E1 component
HR084_10570	COG4548	von Willebrand factor, type A
HR084_10575	COG0714	Associated with various cellular activities
HR084_10580	COG2032	superoxide dismutase activity
HR084_10585	COG0791	NLP P60 protein
HR084_10585	COG1388	LysM domain
HR084_10590	COG1819	glycosyl
HR084_10595	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HR084_10600	COG0534	Mate efflux family protein
HR084_10605	COG1366	Belongs to the anti-sigma-factor antagonist family
HR084_10610	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HR084_10615	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HR084_10625	COG2962	Rard protein
HR084_10645	COG1942	4-Oxalocrotonate Tautomerase
HR084_10650	COG1733	regulation of RNA biosynthetic process
HR084_10655	COG0778	Nitroreductase
HR084_10660	COG0400	carboxylic ester hydrolase activity
HR084_10665	COG0346	lactoylglutathione lyase activity
HR084_10675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HR084_10680	COG3409	Peptidoglycan-binding domain 1 protein
HR084_10680	COG0793	Belongs to the peptidase S41A family
HR084_10685	COG2226	methyltransferase
HR084_10695	COG1876	peptidase activity
HR084_10700	COG0813	purine-nucleoside phosphorylase activity
HR084_10715	COG0671	phosphoesterase, PA-phosphatase related
HR084_10735	COG4479	Belongs to the UPF0346 family
HR084_10745	COG1509	lysine 2,3-aminomutase activity
HR084_10750	COG0456	acetyltransferase
HR084_10755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HR084_10760	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HR084_10765	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HR084_10770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HR084_10785	COG0456	acetyltransferase
HR084_10790	COG0463	Glycosyl transferase, family 2
HR084_10805	COG4641	Protein conserved in bacteria
HR084_10810	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
HR084_10815	COG1086	Polysaccharide biosynthesis protein
HR084_10820	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HR084_10825	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HR084_10830	COG1846	Transcriptional regulator
HR084_10835	COG0534	Mate efflux family protein
HR084_10845	COG4698	Protein conserved in bacteria
HR084_10850	COG2755	lipolytic protein G-D-S-L family
HR084_10855	COG1999	signal sequence binding
HR084_10865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HR084_10870	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HR084_10875	COG1272	protein, Hemolysin III
HR084_10880	COG0204	Acyl-transferase
HR084_10885	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HR084_10890	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HR084_10895	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HR084_10905	COG2136	Putative SAM-dependent methyltransferase
HR084_10905	COG2521	methyltransferase
HR084_10915	COG0129	dihydroxy-acid dehydratase activity
HR084_10920	COG1413	lyase activity
HR084_10925	COG1418	mRNA catabolic process
HR084_10930	COG0386	Belongs to the glutathione peroxidase family
HR084_10935	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HR084_10940	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HR084_10950	COG1278	Cold shock
HR084_10970	COG0328	RNA-DNA hybrid ribonuclease activity
HR084_10975	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HR084_10980	COG0328	RNA-DNA hybrid ribonuclease activity
HR084_10990	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HR084_11005	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HR084_11015	COG1755	Isoprenylcysteine carboxyl methyltransferase
HR084_11020	COG3424	synthase
HR084_11025	COG2233	PERMEase
HR084_11030	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HR084_11035	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HR084_11045	COG0800	Aldolase
HR084_11050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HR084_11055	COG1609	Transcriptional regulator
HR084_11060	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HR084_11065	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_11070	COG1199	ATP-dependent helicase activity
HR084_11085	COG0116	Belongs to the methyltransferase superfamily
HR084_11100	COG4474	Belongs to the UPF0398 family
HR084_11115	COG3359	exonuclease
HR084_11120	COG1111	helicase
HR084_11120	COG1205	dead DEAH box helicase
HR084_11125	COG2190	(PTS) system
HR084_11130	COG0071	Belongs to the small heat shock protein (HSP20) family
HR084_11165	COG3331	DNA recombination
HR084_11170	COG4499	WXG100 protein secretion system (Wss), protein YukC
HR084_11170	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HR084_11180	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HR084_11185	COG3935	DnaD domain protein
HR084_11190	COG0017	Asparaginyl-tRNA synthetase
HR084_11195	COG0436	Aminotransferase
HR084_11200	COG5353	protein conserved in bacteria
HR084_11210	COG1199	ATP-dependent helicase activity
HR084_11210	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HR084_11215	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HR084_11220	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HR084_11225	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HR084_11230	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HR084_11230	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HR084_11235	COG0617	tRNA 3'-terminal CCA addition
HR084_11240	COG0438	transferase activity, transferring glycosyl groups
HR084_11245	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HR084_11250	COG1803	Methylglyoxal synthase
HR084_11255	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HR084_11260	COG1694	Mazg nucleotide pyrophosphohydrolase
HR084_11265	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HR084_11275	COG4347	Protein of unknown function (DUF1405)
HR084_11280	COG2010	Cytochrome c
HR084_11280	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HR084_11285	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HR084_11290	COG0723	plastoquinol--plastocyanin reductase activity
HR084_11300	COG5582	Belongs to the UPF0302 family
HR084_11305	COG0457	Tetratricopeptide repeat
HR084_11310	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HR084_11315	COG0287	Prephenate dehydrogenase
HR084_11320	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HR084_11325	COG0159	tryptophan synthase activity
HR084_11330	COG0133	tryptophan synthase activity
HR084_11335	COG0135	phosphoribosylanthranilate isomerase activity
HR084_11345	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HR084_11350	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HR084_11355	COG4401	Chorismate mutase type I
HR084_11360	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HR084_11365	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HR084_11370	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HR084_11375	COG0105	UTP biosynthetic process
HR084_11380	COG0142	geranyltranstransferase activity
HR084_11385	COG2226	methyltransferase
HR084_11390	COG0142	geranyltranstransferase activity
HR084_11400	COG0302	gtp cyclohydrolase
HR084_11405	COG0776	regulation of translation
HR084_11410	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HR084_11425	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HR084_11430	COG1160	GTP binding
HR084_11455	COG1304	FMN binding
HR084_11460	COG0539	negative regulation of cytoplasmic translation
HR084_11465	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HR084_11475	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HR084_11480	COG2959	enzyme of heme biosynthesis
HR084_11485	COG3773	Cell wall hydrolase
HR084_11485	COG3409	Peptidoglycan-binding domain 1 protein
HR084_11490	COG2339	peptidase activity
HR084_11495	COG0492	ferredoxin-NADP+ reductase activity
HR084_11500	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HR084_11505	COG4862	establishment of competence for transformation
HR084_11510	COG1408	metallophosphoesterase
HR084_11520	COG1388	LysM domain
HR084_11525	COG1266	CAAX protease self-immunity
HR084_11530	COG0514	ATP-dependent DNA helicase (RecQ)
HR084_11535	COG4955	Helix-turn-helix domain
HR084_11540	COG1141	Ferredoxin
HR084_11545	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HR084_11550	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HR084_11555	COG0710	3-dehydroquinate dehydratase activity
HR084_11565	COG1595	DNA-templated transcription, initiation
HR084_11570	COG5002	protein histidine kinase activity
HR084_11575	COG0745	RESPONSE REGULATOR receiver
HR084_11580	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HR084_11585	COG1333	cytochrome c biogenesis protein
HR084_11590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HR084_11595	COG1187	pseudouridine synthase activity
HR084_11600	COG0700	Nucleoside recognition
HR084_11605	COG2715	membrane protein required for spore maturation
HR084_11610	COG1686	Belongs to the peptidase S11 family
HR084_11620	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HR084_11625	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HR084_11630	COG1547	Domain of unknown function (DUF309)
HR084_11635	COG0456	acetyltransferase
HR084_11640	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HR084_11645	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HR084_11645	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HR084_11650	COG0307	riboflavin synthase, alpha
HR084_11655	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HR084_11655	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HR084_11665	COG0681	Belongs to the peptidase S26 family
HR084_11675	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
HR084_11695	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HR084_11700	COG4086	secreted protein
HR084_11705	COG0019	diaminopimelate decarboxylase activity
HR084_11710	COG0697	spore germination
HR084_11725	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HR084_11745	COG1191	sigma factor activity
HR084_11750	COG2172	sigma factor antagonist activity
HR084_11755	COG1366	Belongs to the anti-sigma-factor antagonist family
HR084_11760	COG1686	Belongs to the peptidase S11 family
HR084_11765	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HR084_11770	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HR084_11775	COG4974	Belongs to the 'phage' integrase family
HR084_11785	COG0735	belongs to the Fur family
HR084_11790	COG1300	Membrane
HR084_11800	COG0281	malic enzyme
HR084_11805	COG1757	Na H antiporter
HR084_11810	COG1027	Aspartate ammonia-lyase
HR084_11815	COG0252	asparaginase activity
HR084_11820	COG1396	sequence-specific DNA binding
HR084_11825	COG1379	DNA repair
HR084_11830	COG0494	nUDIX hydrolase
HR084_11840	COG0667	Aldo Keto reductase
HR084_11850	COG1073	alpha beta
HR084_11860	COG4918	Iron-sulphur cluster biosynthesis
HR084_11865	COG0456	acetyltransferase
HR084_11865	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HR084_11870	COG2329	Antibiotic biosynthesis monooxygenase
HR084_11875	COG0456	acetyltransferase
HR084_11885	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HR084_11895	COG2211	Major facilitator Superfamily
HR084_11905	COG0346	lactoylglutathione lyase activity
HR084_11910	COG1072	(Pantothenic acid kinase))
HR084_11915	COG3048	D-serine ammonia-lyase activity
HR084_11920	COG0300	oxidoreductase activity
HR084_11925	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HR084_11930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HR084_11935	COG4187	Peptidase family M20/M25/M40
HR084_11940	COG1902	pentaerythritol trinitrate reductase activity
HR084_11945	COG0596	Alpha beta hydrolase
HR084_11955	COG1234	tRNA 3'-trailer cleavage
HR084_11960	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HR084_11965	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HR084_11970	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HR084_11980	COG0706	membrane insertase activity
HR084_11985	COG3361	conserved protein (COG2071)
HR084_11990	COG2195	Cleaves the N-terminal amino acid of tripeptides
HR084_11995	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HR084_12000	COG0346	lactoylglutathione lyase activity
HR084_12010	COG1376	ErfK ybiS ycfS ynhG family protein
HR084_12015	COG4129	membrane
HR084_12020	COG1126	abc transporter atp-binding protein
HR084_12025	COG0765	amino acid transport
HR084_12030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HR084_12040	COG1597	lipid kinase activity
HR084_12045	COG2814	Major facilitator Superfamily
HR084_12050	COG0789	Transcriptional regulator
HR084_12050	COG4978	Transcriptional regulator
HR084_12055	COG0508	dehydrogenase complex catalyzes the overall conversion of
HR084_12060	COG0022	dehydrogenase e1 component
HR084_12065	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HR084_12070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HR084_12075	COG3426	butyrate kinase activity
HR084_12080	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HR084_12085	COG0280	phosphate acetyltransferase
HR084_12090	COG3829	transcription factor binding
HR084_12090	COG3290	protein histidine kinase activity
HR084_12100	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HR084_12105	COG2079	MmgE PrpD family protein
HR084_12110	COG0372	Belongs to the citrate synthase family
HR084_12115	COG1960	acyl-CoA dehydrogenase activity
HR084_12120	COG1250	3-hydroxyacyl-CoA dehydrogenase
HR084_12125	COG0183	Belongs to the thiolase family
HR084_12130	COG0584	glycerophosphoryl diester phosphodiesterase
HR084_12135	COG0860	N-Acetylmuramoyl-L-alanine amidase
HR084_12150	COG1902	pentaerythritol trinitrate reductase activity
HR084_12155	COG0745	RESPONSE REGULATOR receiver
HR084_12160	COG0750	zinc metalloprotease
HR084_12165	COG0497	DNA recombination
HR084_12170	COG1438	arginine binding
HR084_12175	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HR084_12180	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HR084_12185	COG0142	geranyltranstransferase activity
HR084_12190	COG1722	exodeoxyribonuclease VII activity
HR084_12195	COG1570	exodeoxyribonuclease VII activity
HR084_12200	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HR084_12205	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HR084_12210	COG1302	Protein conserved in bacteria
HR084_12215	COG0439	Biotin carboxylase
HR084_12220	COG0511	ligase activity, forming carbon-carbon bonds
HR084_12260	COG3854	ATPases associated with a variety of cellular activities
HR084_12270	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HR084_12275	COG0006	proline dipeptidase activity
HR084_12280	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HR084_12290	COG3872	metal-dependent enzyme
HR084_12300	COG1752	Esterase of the alpha-beta hydrolase superfamily
HR084_12305	COG1321	iron dependent repressor
HR084_12310	COG0095	Lipoate-protein ligase
HR084_12315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HR084_12320	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HR084_12325	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HR084_12330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HR084_12335	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HR084_12350	COG1396	sequence-specific DNA binding
HR084_12360	COG0681	Belongs to the peptidase S26 family
HR084_12385	COG4940	Competence protein ComGF
HR084_12395	COG4970	Tfp pilus assembly protein FimT
HR084_12400	COG4537	Required for transformation and DNA binding
HR084_12405	COG1459	type II secretion system
HR084_12410	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HR084_12415	COG0598	Magnesium transport protein CorA
HR084_12420	COG1253	flavin adenine dinucleotide binding
HR084_12425	COG1366	Belongs to the anti-sigma-factor antagonist family
HR084_12435	COG1393	Belongs to the ArsC family
HR084_12445	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HR084_12455	COG0011	TIGRFAM Protein of
HR084_12465	COG2866	Carboxypeptidase
HR084_12470	COG1368	sulfuric ester hydrolase activity
HR084_12475	COG1940	carbohydrate kinase activity
HR084_12480	COG4483	Protein conserved in bacteria
HR084_12485	COG0457	Tetratricopeptide repeat
HR084_12485	COG0705	Rhomboid family
HR084_12495	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HR084_12505	COG0438	transferase activity, transferring glycosyl groups
HR084_12520	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HR084_12525	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HR084_12530	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HR084_12535	COG0581	inorganic phosphate transmembrane transporter activity
HR084_12540	COG0573	inorganic phosphate transmembrane transporter activity
HR084_12545	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HR084_12555	COG0477	Major facilitator Superfamily
HR084_12560	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HR084_12565	COG2839	Protein conserved in bacteria
HR084_12570	COG5521	maltodextrose utilization protein MalA
HR084_12575	COG1388	LysM domain
HR084_12580	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HR084_12585	COG4709	membrane
HR084_12590	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HR084_12595	COG0735	belongs to the Fur family
HR084_12600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HR084_12610	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HR084_12615	COG0513	Belongs to the DEAD box helicase family
HR084_12625	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HR084_12630	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HR084_12635	COG2384	SAM-dependent methyltransferase
HR084_12640	COG2010	Cytochrome c
HR084_12645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HR084_12650	COG0358	DNA primase activity
HR084_12655	COG1671	Belongs to the UPF0178 family
HR084_12660	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HR084_12665	COG0517	IMP dehydrogenase activity
HR084_12670	COG0751	glycine-tRNA ligase activity
HR084_12675	COG0752	glycyl-tRNA synthetase alpha subunit
HR084_12680	COG1381	Involved in DNA repair and RecF pathway recombination
HR084_12690	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HR084_12695	COG0295	cytidine deaminase activity
HR084_12700	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HR084_12705	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HR084_12710	COG1480	7TM receptor with intracellular HD hydrolase
HR084_12715	COG1702	phosphate starvation-inducible protein PhoH
HR084_12720	COG0561	phosphatase activity
HR084_12735	COG4864	UPF0365 protein
HR084_12740	COG1030	water channel activity
HR084_12745	COG1610	YqeY-like protein
HR084_12755	COG1283	sodium-dependent phosphate transmembrane transporter activity
HR084_12760	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HR084_12765	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HR084_12770	COG2264	protein methyltransferase activity
HR084_12775	COG0484	heat shock protein binding
HR084_12780	COG0443	Heat shock 70 kDa protein
HR084_12785	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HR084_12790	COG1420	regulation of RNA biosynthetic process
HR084_12795	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HR084_12800	COG0481	GTPase activity
HR084_12810	COG0860	N-Acetylmuramoyl-L-alanine amidase
HR084_12815	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HR084_12820	COG0268	Binds directly to 16S ribosomal RNA
HR084_12825	COG1466	dna polymerase III delta subunit
HR084_12840	COG0658	competence protein
HR084_12840	COG2333	competence protein COMEC
HR084_12845	COG2131	deaminase
HR084_12850	COG1596	polysaccharide export
HR084_12850	COG1555	photosystem II stabilization
HR084_12855	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HR084_12860	COG2226	methyltransferase
HR084_12865	COG0799	negative regulation of ribosome biogenesis
HR084_12870	COG1713	HD superfamily hydrolase involved in NAD metabolism
HR084_12875	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HR084_12880	COG1534	Rna-binding protein
HR084_12885	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HR084_12890	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HR084_12895	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HR084_12905	COG2755	lipolytic protein G-D-S-L family
HR084_12910	COG3409	Peptidoglycan-binding domain 1 protein
HR084_12910	COG5632	N-Acetylmuramoyl-L-alanine amidase
HR084_12915	COG0398	Pfam SNARE associated Golgi protein
HR084_12920	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HR084_12930	COG3209	COG3209 Rhs family protein
HR084_12940	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HR084_12960	COG0300	oxidoreductase activity
HR084_12965	COG1902	pentaerythritol trinitrate reductase activity
HR084_12970	COG0508	dehydrogenase complex catalyzes the overall conversion of
HR084_12970	COG0596	Alpha beta hydrolase
HR084_12975	COG1309	transcriptional regulator
HR084_12985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HR084_12990	COG1331	Highly conserved protein containing a thioredoxin domain
HR084_12995	COG0346	lactoylglutathione lyase activity
HR084_13000	COG0640	Transcriptional regulator
HR084_13015	COG0604	alcohol dehydrogenase
HR084_13025	COG0457	Tetratricopeptide repeat
HR084_13040	COG5444	nuclease activity
HR084_13050	COG4282	regulation of fungal-type cell wall biogenesis
HR084_13120	COG0563	adenylate kinase activity
HR084_13125	COG2856	Zn peptidase
HR084_13135	COG5002	protein histidine kinase activity
HR084_13135	COG0642	Histidine kinase
HR084_13140	COG0745	RESPONSE REGULATOR receiver
HR084_13145	COG2311	Membrane
HR084_13155	COG0454	-acetyltransferase
HR084_13160	COG2249	NAD(P)H dehydrogenase (quinone) activity
HR084_13170	COG0730	response to heat
HR084_13175	COG0425	Belongs to the sulfur carrier protein TusA family
HR084_13180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HR084_13180	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HR084_13190	COG0425	Belongs to the sulfur carrier protein TusA family
HR084_13190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HR084_13200	COG1937	Protein conserved in bacteria
HR084_13205	COG0662	Cupin 2, conserved barrel domain protein
HR084_13215	COG4978	Transcriptional regulator
HR084_13215	COG0789	Transcriptional regulator
HR084_13220	COG2814	Major facilitator Superfamily
HR084_13225	COG0456	acetyltransferase
HR084_13230	COG1253	flavin adenine dinucleotide binding
HR084_13240	COG0697	spore germination
HR084_13245	COG0583	DNA-binding transcription factor activity
HR084_13250	COG2072	flavoprotein involved in K transport
HR084_13255	COG1230	cation diffusion facilitator family transporter
HR084_13260	COG1942	4-Oxalocrotonate Tautomerase
HR084_13265	COG0583	DNA-binding transcription factor activity
HR084_13275	COG1114	Component of the transport system for branched-chain amino acids
HR084_13280	COG1687	branched-chain amino acid
HR084_13285	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HR084_13290	COG1522	sequence-specific DNA binding
HR084_13295	COG2732	(Barnase) inhibitor
HR084_13300	COG2124	cytochrome p450
HR084_13305	COG1335	isochorismatase
HR084_13320	COG2318	DinB family
HR084_13330	COG2070	2-Nitropropane dioxygenase
HR084_13335	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HR084_13355	COG3443	Belongs to the bacterial solute-binding protein 9 family
HR084_13360	COG1595	DNA-templated transcription, initiation
HR084_13365	COG0667	Aldo Keto reductase
HR084_13370	COG2851	Citrate transporter
HR084_13375	COG0583	DNA-binding transcription factor activity
HR084_13380	COG2828	Protein conserved in bacteria
HR084_13385	COG3409	Peptidoglycan-binding domain 1 protein
HR084_13390	COG5566	PFAM Mor transcription activator
HR084_13395	COG0596	Alpha beta hydrolase
HR084_13400	COG4991	sh3 domain protein
HR084_13405	COG4991	sh3 domain protein
HR084_13410	COG0346	lactoylglutathione lyase activity
HR084_13420	COG5577	PFAM Coat F domain
HR084_13425	COG1063	alcohol dehydrogenase
HR084_13435	COG5577	PFAM Coat F domain
HR084_13440	COG0789	Transcriptional regulator
HR084_13450	COG1064	alcohol dehydrogenase
HR084_13455	COG0693	protein deglycase activity
HR084_13460	COG1621	beta-fructofuranosidase activity
HR084_13465	COG3716	PTS system mannose fructose sorbose family IID component
HR084_13470	COG3715	PTS system
HR084_13475	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HR084_13480	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HR084_13485	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HR084_13485	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HR084_13495	COG1113	amino acid transport
HR084_13500	COG1280	lysine exporter protein (LysE YggA)
HR084_13505	COG1378	Sugar-specific transcriptional regulator TrmB
HR084_13510	COG1595	DNA-templated transcription, initiation
HR084_13520	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HR084_13520	COG2755	lipolytic protein G-D-S-L family
HR084_13530	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HR084_13530	COG2124	cytochrome p450
HR084_13535	COG1309	transcriptional regulator
HR084_13540	COG2226	methyltransferase
HR084_13555	COG2116	formate transmembrane transporter activity
HR084_13560	COG5609	conserved protein (DUF2294)
HR084_13565	COG3383	formate dehydrogenase (NAD+) activity
HR084_13570	COG2427	Protein of unknown function (DUF1641)
HR084_13580	COG0626	cystathionine gamma-synthase activity
HR084_13585	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HR084_13590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HR084_13595	COG2226	methyltransferase
HR084_13610	COG0768	penicillin binding
HR084_13615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HR084_13620	COG0572	uridine kinase
HR084_13635	COG4122	O-methyltransferase activity
HR084_13640	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HR084_13645	COG3906	Belongs to the UPF0473 family
HR084_13650	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HR084_13655	COG4472	Bacterial protein of unknown function (DUF965)
HR084_13660	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HR084_13665	COG0628	permease
HR084_13670	COG1126	abc transporter atp-binding protein
HR084_13675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HR084_13680	COG0765	amino acid transport
HR084_13685	COG0765	amino acid transport
HR084_13700	COG3881	PFAM PRC-barrel domain
HR084_13705	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HR084_13710	COG0457	Tetratricopeptide repeat
HR084_13715	COG0482	sulfurtransferase activity
HR084_13720	COG1104	cysteine desulfurase activity
HR084_13725	COG1959	2 iron, 2 sulfur cluster binding
HR084_13730	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HR084_13735	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HR084_13745	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HR084_13750	COG0124	histidyl-tRNA synthetase
HR084_13760	COG3103	Sh3 type 3 domain protein
HR084_13760	COG0860	N-Acetylmuramoyl-L-alanine amidase
HR084_13760	COG4991	sh3 domain protein
HR084_13765	COG1490	D-aminoacyl-tRNA deacylase activity
HR084_13770	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HR084_13775	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HR084_13780	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HR084_13780	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HR084_13785	COG5416	Lipopolysaccharide assembly protein A domain
HR084_13790	COG0490	domain, Protein
HR084_13795	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HR084_13795	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HR084_13805	COG2244	polysaccharide biosynthetic process
HR084_13810	COG2323	membrane
HR084_13820	COG1862	Preprotein translocase
HR084_13825	COG0343	queuine tRNA-ribosyltransferase activity
HR084_13830	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HR084_13840	COG2255	four-way junction helicase activity
HR084_13845	COG0632	four-way junction helicase activity
HR084_13855	COG2814	Major facilitator Superfamily
HR084_13860	COG0673	inositol 2-dehydrogenase activity
HR084_13865	COG2112	serine threonine protein kinase
HR084_13885	COG1115	amino acid carrier protein
HR084_13890	COG0217	transcriptional regulatory protein
HR084_13900	COG1388	LysM domain
HR084_13905	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HR084_13910	COG0157	Belongs to the NadC ModD family
HR084_13915	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HR084_13920	COG1104	cysteine desulfurase activity
HR084_13925	COG1827	regulation of RNA biosynthetic process
HR084_13930	COG0077	Prephenate dehydratase
HR084_13935	COG4492	Belongs to the UPF0735 family
HR084_13940	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HR084_13945	COG3290	protein histidine kinase activity
HR084_13955	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HR084_13960	COG2868	ribosomal protein
HR084_13965	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HR084_13970	COG1994	Peptidase M50
HR084_13975	COG0739	heme binding
HR084_13980	COG2894	cell division
HR084_13985	COG0850	regulation of cytokinetic process
HR084_13990	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HR084_14000	COG1077	Cell shape determining protein MreB Mrl
HR084_14005	COG2003	Belongs to the UPF0758 family
HR084_14010	COG0424	maF-like protein
HR084_14020	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HR084_14025	COG0285	dihydrofolate synthase activity
HR084_14030	COG0525	valine-tRNA ligase activity
HR084_14040	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HR084_14045	COG1388	LysM domain
HR084_14050	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HR084_14055	COG0113	porphobilinogen synthase activity
HR084_14060	COG1587	Uroporphyrinogen-III synthase
HR084_14065	COG0181	hydroxymethylbilane synthase activity
HR084_14070	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HR084_14075	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HR084_14085	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HR084_14090	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HR084_14095	COG1067	ATP-dependent peptidase activity
HR084_14095	COG0470	DNA polymerase III
HR084_14100	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HR084_14105	COG0544	peptidyl-prolyl cis-trans isomerase activity
HR084_14110	COG0457	Tetratricopeptide repeat
HR084_14110	COG1477	protein flavinylation
HR084_14115	COG0066	3-isopropylmalate dehydratase activity
HR084_14120	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HR084_14125	COG0473	3-isopropylmalate dehydrogenase activity
HR084_14130	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HR084_14135	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HR084_14140	COG0440	acetolactate synthase activity
HR084_14145	COG0028	Belongs to the TPP enzyme family
HR084_14155	COG0454	-acetyltransferase
HR084_14160	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HR084_14170	COG0622	Phosphoesterase
HR084_14175	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HR084_14180	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HR084_14185	COG5401	PFAM Sporulation and spore germination
HR084_14190	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HR084_14195	COG1846	Transcriptional regulator
HR084_14200	COG2197	response regulator
HR084_14205	COG0824	Thioesterase
HR084_14210	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HR084_14215	COG1053	succinate dehydrogenase
HR084_14220	COG2009	succinate dehydrogenase
HR084_14225	COG1719	4-vinyl reductase, 4VR
HR084_14230	COG0527	aspartate kinase activity
HR084_14235	COG0322	excinuclease ABC activity
HR084_14240	COG3118	belongs to the thioredoxin family
HR084_14245	COG3534	alpha-L-arabinofuranosidase
HR084_14250	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HR084_14255	COG2086	electron transfer activity
HR084_14260	COG1024	Enoyl-CoA hydratase
HR084_14265	COG1309	transcriptional regulator
HR084_14270	COG0318	PFAM AMP-dependent synthetase and ligase
HR084_14275	COG3766	membrane
HR084_14280	COG1193	negative regulation of DNA recombination
HR084_14285	COG1796	DNA polymerase
HR084_14285	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HR084_14290	COG1286	toxin biosynthetic process
HR084_14295	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HR084_14300	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HR084_14305	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HR084_14305	COG0072	phenylalanine-tRNA ligase activity
HR084_14310	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HR084_14320	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HR084_14330	COG3835	regulator
HR084_14335	COG0277	FAD linked oxidase domain protein
HR084_14340	COG0247	lactate metabolic process
HR084_14345	COG0346	lactoylglutathione lyase activity
HR084_14350	COG1966	Carbon starvation protein
HR084_14355	COG3534	alpha-L-arabinofuranosidase
HR084_14360	COG0395	ABC-type sugar transport system, permease component
HR084_14365	COG1175	transmembrane transport
HR084_14370	COG1653	transport
HR084_14375	COG0371	Dehydrogenase
HR084_14380	COG0647	UMP catabolic process
HR084_14385	COG0235	Class ii aldolase
HR084_14390	COG1069	ribulokinase activity
HR084_14395	COG2160	L-arabinose isomerase activity
HR084_14400	COG3507	Belongs to the glycosyl hydrolase 43 family
HR084_14405	COG1363	Peptidase, m42
HR084_14415	COG3326	Membrane
HR084_14420	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HR084_14425	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HR084_14430	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HR084_14440	COG1346	cytolysis
HR084_14445	COG1380	Effector of murein hydrolase LrgA
HR084_14450	COG3279	Response regulator of the LytR AlgR family
HR084_14455	COG3275	phosphorelay sensor kinase activity
HR084_14460	COG1011	Hydrolase
HR084_14465	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HR084_14475	COG0398	Pfam SNARE associated Golgi protein
HR084_14480	COG1484	DNA-dependent DNA replication
HR084_14485	COG3611	Membrane attachment protein
HR084_14490	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HR084_14495	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HR084_14500	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HR084_14505	COG1733	regulation of RNA biosynthetic process
HR084_14510	COG2814	Major facilitator Superfamily
HR084_14515	COG0656	L-ascorbic acid biosynthetic process
HR084_14520	COG0237	dephospho-CoA kinase activity
HR084_14525	COG1971	Probably functions as a manganese efflux pump
HR084_14530	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HR084_14535	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HR084_14535	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HR084_14540	COG5002	protein histidine kinase activity
HR084_14545	COG0745	RESPONSE REGULATOR receiver
HR084_14550	COG0039	L-malate dehydrogenase activity
HR084_14555	COG0538	isocitrate dehydrogenase activity
HR084_14560	COG0372	Belongs to the citrate synthase family
HR084_14565	COG2707	UPF0756 membrane protein
HR084_14570	COG0628	permease
HR084_14575	COG3030	protein affecting phage T7 exclusion by the F plasmid
HR084_14580	COG0469	pyruvate kinase activity
HR084_14585	COG0205	6-phosphofructokinase activity
HR084_14590	COG0825	malonyl-CoA metabolic process
HR084_14595	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HR084_14600	COG0281	malic enzyme
HR084_14605	COG0587	DNA-directed DNA polymerase activity
HR084_14625	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HR084_14635	COG4109	DRTGG domain
HR084_14640	COG0730	response to heat
HR084_14645	COG1473	amidohydrolase
HR084_14650	COG0196	riboflavin kinase activity
HR084_14655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HR084_14660	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HR084_14665	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HR084_14670	COG1126	abc transporter atp-binding protein
HR084_14675	COG0765	amino acid transport
HR084_14680	COG0765	amino acid transport
HR084_14685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HR084_14690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HR084_14695	COG0454	-acetyltransferase
HR084_14700	COG0583	DNA-binding transcription factor activity
HR084_14705	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HR084_14710	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_14715	COG0165	Argininosuccinate lyase
HR084_14720	COG0137	argininosuccinate synthase activity
HR084_14725	COG0521	Mo-molybdopterin cofactor biosynthetic process
HR084_14730	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HR084_14740	COG0827	DNA restriction-modification system
HR084_14745	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HR084_14750	COG3874	Sporulation protein YtfJ
HR084_14760	COG1714	RDD family
HR084_14765	COG0616	signal peptide processing
HR084_14770	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HR084_14775	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HR084_14780	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HR084_14790	COG0301	tRNA thio-modification
HR084_14795	COG1104	cysteine desulfurase activity
HR084_14800	COG1114	Component of the transport system for branched-chain amino acids
HR084_14805	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HR084_14810	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HR084_14815	COG1309	transcriptional regulator
HR084_14820	COG1956	GAF domain-containing protein
HR084_14825	COG2199	diguanylate cyclase activity
HR084_14825	COG2203	Gaf domain
HR084_14830	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HR084_14835	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HR084_14840	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HR084_14845	COG0454	-acetyltransferase
HR084_14850	COG0517	IMP dehydrogenase activity
HR084_14855	COG0123	including yeast histone deacetylase and acetoin utilization protein
HR084_14860	COG1360	Flagellar Motor Protein
HR084_14865	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HR084_14870	COG1609	Transcriptional regulator
HR084_14875	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HR084_14875	COG1605	Chorismate mutase
HR084_14880	COG3118	belongs to the thioredoxin family
HR084_14885	COG4980	gas vesicle protein
HR084_14890	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HR084_14895	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HR084_14900	COG1674	ftsk spoiiie
HR084_14905	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HR084_14910	COG4848	Belongs to the UPF0354 family
HR084_14915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HR084_14930	COG1363	Peptidase, m42
HR084_14935	COG5584	Small secreted protein
HR084_14940	COG0281	malic enzyme
HR084_14945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HR084_14950	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HR084_14960	COG0510	thiamine kinase activity
HR084_14965	COG1523	belongs to the glycosyl hydrolase 13 family
HR084_14970	COG1597	lipid kinase activity
HR084_14980	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HR084_14985	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HR084_14990	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HR084_14995	COG2252	PERMEase
HR084_15000	COG4473	ABC transporter
HR084_15005	COG1131	(ABC) transporter
HR084_15010	COG1349	DNA-binding transcription factor activity
HR084_15015	COG1187	pseudouridine synthase activity
HR084_15020	COG2244	polysaccharide biosynthetic process
HR084_15025	COG2081	HI0933 family
HR084_15030	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HR084_15040	COG5578	integral membrane protein
HR084_15045	COG0673	inositol 2-dehydrogenase activity
HR084_15050	COG1653	transport
HR084_15055	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HR084_15060	COG4209	transmembrane transport
HR084_15065	COG2207	Transcriptional regulator
HR084_15070	COG1653	transport
HR084_15075	COG0395	ABC-type sugar transport system, permease component
HR084_15080	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HR084_15085	COG2124	cytochrome p450
HR084_15090	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HR084_15100	COG0156	8-amino-7-oxononanoate synthase activity
HR084_15105	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HR084_15110	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
HR084_15115	COG1073	alpha beta
HR084_15120	COG1609	Transcriptional regulator
HR084_15125	COG1653	transport
HR084_15130	COG1175	transmembrane transport
HR084_15135	COG0395	ABC-type sugar transport system, permease component
HR084_15140	COG1486	melibiose metabolic process
HR084_15145	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HR084_15150	COG0495	leucyl-tRNA aminoacylation
HR084_15160	COG2202	Pas domain
HR084_15160	COG1366	Belongs to the anti-sigma-factor antagonist family
HR084_15165	COG2814	Major facilitator Superfamily
HR084_15170	COG2433	Pfam Transposase IS66
HR084_15175	COG0577	efflux transmembrane transporter activity
HR084_15180	COG1136	(ABC) transporter
HR084_15185	COG2205	protein histidine kinase activity
HR084_15190	COG0745	RESPONSE REGULATOR receiver
HR084_15195	COG0577	efflux transmembrane transporter activity
HR084_15200	COG1136	(ABC) transporter
HR084_15215	COG1131	(ABC) transporter
HR084_15220	COG1725	Transcriptional regulator
HR084_15235	COG1242	4 iron, 4 sulfur cluster binding
HR084_15240	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HR084_15250	COG2267	carboxylic ester hydrolase activity
HR084_15255	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HR084_15260	COG1113	amino acid transport
HR084_15265	COG0367	asparagine synthase
HR084_15270	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HR084_15275	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HR084_15285	COG1506	peptidase
HR084_15290	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HR084_15295	COG1116	anion transmembrane transporter activity
HR084_15300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HR084_15305	COG0494	nUDIX hydrolase
HR084_15310	COG4824	toxin secretion phage lysis holin
HR084_15315	COG0783	Belongs to the Dps family
HR084_15330	COG1854	S-ribosylhomocysteine lyase activity
HR084_15335	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HR084_15340	COG0288	reversible hydration of carbon dioxide
HR084_15345	COG0254	rRNA binding
HR084_15350	COG1271	oxidase subunit
HR084_15355	COG1294	oxidase, subunit
HR084_15365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HR084_15370	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HR084_15370	COG1321	iron dependent repressor
HR084_15375	COG1121	(ABC) transporter
HR084_15380	COG0803	Belongs to the bacterial solute-binding protein 9 family
HR084_15385	COG4948	Mandelate Racemase Muconate Lactonizing
HR084_15390	COG0318	PFAM AMP-dependent synthetase and ligase
HR084_15395	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HR084_15400	COG0596	Alpha beta hydrolase
HR084_15405	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HR084_15410	COG1169	isochorismate synthase
HR084_15415	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HR084_15420	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HR084_15425	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HR084_15430	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HR084_15435	COG0438	transferase activity, transferring glycosyl groups
HR084_15445	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HR084_15450	COG0438	transferase activity, transferring glycosyl groups
HR084_15455	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HR084_15460	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HR084_15465	COG0058	SHG alpha-glucan phosphorylase activity
HR084_15470	COG0297	glycogen (starch) synthase activity
HR084_15475	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HR084_15480	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HR084_15485	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HR084_15610	COG3859	Proton-coupled thiamine transporter YuaJ
HR084_15615	COG1247	-acetyltransferase
HR084_15620	COG2268	Band 7 protein
HR084_15625	COG1585	Membrane protein implicated in regulation of membrane protease activity
HR084_15630	COG2318	DinB family
HR084_15640	COG1454	alcohol dehydrogenase
HR084_15645	COG1012	belongs to the aldehyde dehydrogenase family
HR084_15650	COG1510	regulation of RNA biosynthetic process
HR084_15660	COG0569	domain protein
HR084_15665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HR084_15670	COG4682	membrane
HR084_15675	COG1705	Flagellar rod assembly protein muramidase FlgJ
HR084_15680	COG0477	Major facilitator Superfamily
HR084_15685	COG5553	Cysteine dioxygenase type I
HR084_15695	COG1968	undecaprenyl-diphosphatase activity
HR084_15700	COG0628	permease
HR084_15705	COG0673	inositol 2-dehydrogenase activity
HR084_15710	COG4806	L-rhamnose isomerase
HR084_15715	COG3254	rhamnose metabolic process
HR084_15720	COG1070	Carbohydrate kinase
HR084_15725	COG1349	DNA-binding transcription factor activity
HR084_15730	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_15730	COG3347	Dehydrogenase
HR084_15735	COG0840	transmembrane signaling receptor activity
HR084_15740	COG0840	transmembrane signaling receptor activity
HR084_15745	COG0840	transmembrane signaling receptor activity
HR084_15750	COG0840	transmembrane signaling receptor activity
HR084_15765	COG0432	Pfam Uncharacterised protein family UPF0047
HR084_15775	COG0366	Alpha amylase catalytic
HR084_15780	COG1253	flavin adenine dinucleotide binding
HR084_15785	COG2738	Putative neutral zinc metallopeptidase
HR084_15800	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HR084_15815	COG0166	Belongs to the GPI family
HR084_15820	COG1979	alcohol dehydrogenase
HR084_15825	COG1979	alcohol dehydrogenase
HR084_15830	COG2155	Conserved Protein
HR084_15835	COG1098	S1 RNA binding domain
HR084_15840	COG0436	Aminotransferase
HR084_15845	COG1522	sequence-specific DNA binding
HR084_15850	COG2267	carboxylic ester hydrolase activity
HR084_15860	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HR084_15865	COG2205	protein histidine kinase activity
HR084_15875	COG5018	Exonuclease
HR084_15880	COG2814	Major facilitator Superfamily
HR084_15885	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HR084_15890	COG3011	Protein conserved in bacteria
HR084_15900	COG3290	protein histidine kinase activity
HR084_15905	COG4565	transcriptional regulatory protein
HR084_15930	COG3493	citrate carrier protein
HR084_15940	COG2111	Na H antiporter
HR084_15940	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HR084_15945	COG2111	Na H antiporter
HR084_15950	COG1006	Multisubunit Na H antiporter MnhC subunit
HR084_15955	COG0651	ATP synthesis coupled electron transport
HR084_15960	COG1863	multisubunit Na H antiporter MnhE subunit
HR084_15965	COG2212	antiporter activity
HR084_15970	COG1320	monovalent cation:proton antiporter activity
HR084_15975	COG2050	protein possibly involved in aromatic compounds catabolism
HR084_15980	COG2197	response regulator
HR084_15995	COG0142	geranyltranstransferase activity
HR084_16015	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HR084_16020	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HR084_16025	COG1335	isochorismatase
HR084_16030	COG5506	Protein of unknown function (DUF1694)
HR084_16045	COG0628	permease
HR084_16060	COG1418	mRNA catabolic process
HR084_16065	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_16075	COG1511	domain protein
HR084_16080	COG0433	COG0433 Predicted ATPase
HR084_16080	COG1674	ftsk spoiiie
HR084_16085	COG4499	WXG100 protein secretion system (Wss), protein YukC
HR084_16090	COG5417	Belongs to the EsaB family
HR084_16095	COG4842	Belongs to the WXG100 family
HR084_16100	COG2508	Transcriptional regulator
HR084_16100	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HR084_16105	COG0686	Belongs to the AlaDH PNT family
HR084_16110	COG5634	Uncharacterized conserved protein (DUF2278)
HR084_16115	COG3251	PFAM MbtH domain protein
HR084_16120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HR084_16125	COG1535	isochorismatase
HR084_16125	COG3433	isochorismatase activity
HR084_16130	COG1021	2,3-dihydroxybenzoate-AMP ligase
HR084_16135	COG1169	isochorismate synthase
HR084_16140	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_16145	COG2819	hydrolase of the alpha beta superfamily
HR084_16150	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HR084_16155	COG1268	BioY protein
HR084_16160	COG2056	Na+-H+ antiporter family
HR084_16165	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HR084_16170	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HR084_16175	COG3584	3D domain protein
HR084_16190	COG1252	NADH dehydrogenase
HR084_16195	COG0492	ferredoxin-NADP+ reductase activity
HR084_16205	COG0516	GMP reductase activity
HR084_16210	COG2808	Putative FMN-binding domain
HR084_16215	COG0456	acetyltransferase
HR084_16220	COG0316	Belongs to the HesB IscA family
HR084_16225	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HR084_16230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HR084_16235	COG4844	belongs to the
HR084_16240	COG1252	NADH dehydrogenase
HR084_16245	COG4837	Protein of unknown function (DUF1462)
HR084_16250	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HR084_16255	COG4946	Tricorn protease homolog
HR084_16255	COG0823	Involved in the tonB-independent uptake of proteins
HR084_16255	COG1506	peptidase
HR084_16260	COG0083	homoserine kinase activity
HR084_16265	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HR084_16270	COG0460	homoserine dehydrogenase
HR084_16275	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HR084_16280	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HR084_16285	COG0647	UMP catabolic process
HR084_16290	COG2445	Protein of unknown function DUF86
HR084_16295	COG4470	Protein conserved in bacteria
HR084_16305	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HR084_16310	COG0739	heme binding
HR084_16320	COG3377	Domain of unknown function (DUF1805)
HR084_16325	COG0737	Belongs to the 5'-nucleotidase family
HR084_16330	COG0730	response to heat
HR084_16335	COG1801	Protein of unknown function DUF72
HR084_16345	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HR084_16350	COG2508	Transcriptional regulator
HR084_16355	COG2233	PERMEase
HR084_16360	COG2233	PERMEase
HR084_16365	COG3195	allantoin biosynthetic process
HR084_16365	COG3648	Uricase
HR084_16370	COG2351	hydroxyisourate hydrolase activity
HR084_16380	COG2080	2 iron, 2 sulfur cluster binding
HR084_16385	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HR084_16390	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HR084_16395	COG2068	MobA-Related Protein
HR084_16400	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HR084_16405	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HR084_16410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HR084_16420	COG2356	endonuclease I
HR084_16425	COG3842	ATPase activity
HR084_16430	COG2188	Transcriptional regulator
HR084_16435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HR084_16440	COG0395	ABC-type sugar transport system, permease component
HR084_16445	COG1175	transmembrane transport
HR084_16450	COG1653	transport
HR084_16455	COG2222	sugar isomerase
HR084_16460	COG0322	excinuclease ABC activity
HR084_16465	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HR084_16480	COG0719	Fe-S assembly protein
HR084_16485	COG0822	iron-sulfur transferase activity
HR084_16490	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HR084_16495	COG0719	Fe-S assembly protein
HR084_16500	COG0396	ATPase activity
HR084_16510	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HR084_16515	COG1464	Belongs to the NlpA lipoprotein family
HR084_16520	COG2011	ABC-type metal ion transport system permease component
HR084_16525	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HR084_16535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HR084_16540	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HR084_16550	COG0509	glycine decarboxylation via glycine cleavage system
HR084_16555	COG1393	Belongs to the ArsC family
HR084_16560	COG1960	acyl-CoA dehydrogenase activity
HR084_16565	COG0183	Belongs to the thiolase family
HR084_16570	COG1250	3-hydroxyacyl-CoA dehydrogenase
HR084_16570	COG1024	Enoyl-CoA hydratase
HR084_16580	COG0506	proline dehydrogenase activity
HR084_16590	COG5577	PFAM Coat F domain
HR084_16595	COG1846	Transcriptional regulator
HR084_16600	COG0477	Major facilitator Superfamily
HR084_16605	COG1942	4-Oxalocrotonate Tautomerase
HR084_16610	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_16615	COG0583	DNA-binding transcription factor activity
HR084_16625	COG1120	ATPase activity
HR084_16640	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_16645	COG0783	Belongs to the Dps family
HR084_16650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HR084_16655	COG0745	RESPONSE REGULATOR receiver
HR084_16660	COG2205	protein histidine kinase activity
HR084_16660	COG2770	Histidine kinase
HR084_16670	COG1309	transcriptional regulator
HR084_16675	COG0114	fumarate hydratase activity
HR084_16685	COG0697	spore germination
HR084_16690	COG0814	amino acid
HR084_16700	COG2197	response regulator
HR084_16705	COG4585	Histidine kinase
HR084_16710	COG4758	membrane
HR084_16715	COG3595	metallopeptidase activity
HR084_16720	COG1842	Phage shock protein A
HR084_16725	COG4758	membrane
HR084_16730	COG2814	Major facilitator Superfamily
HR084_16735	COG2096	Adenosyltransferase
HR084_16740	COG1120	ATPase activity
HR084_16745	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HR084_16750	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HR084_16755	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_16760	COG3386	PFAM SMP-30 Gluconolaconase
HR084_16765	COG2205	protein histidine kinase activity
HR084_16770	COG0745	RESPONSE REGULATOR receiver
HR084_16780	COG1191	sigma factor activity
HR084_16790	COG2140	Oxalate decarboxylase
HR084_16800	COG0577	efflux transmembrane transporter activity
HR084_16805	COG1136	(ABC) transporter
HR084_16810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HR084_16815	COG1120	ATPase activity
HR084_16820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HR084_16825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HR084_16830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HR084_16835	COG0531	amino acid
HR084_16845	COG1988	membrane-bound metal-dependent
HR084_16850	COG1368	sulfuric ester hydrolase activity
HR084_16855	COG1910	domain protein
HR084_16860	COG0725	ABC transporter, periplasmic molybdate-binding protein
HR084_16865	COG4149	molybdate abc transporter
HR084_16870	COG0656	L-ascorbic acid biosynthetic process
HR084_16880	COG0025	NhaP-type Na H and K H
HR084_16885	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HR084_16890	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HR084_16895	COG3973	AAA domain
HR084_16900	COG2860	membrane
HR084_16905	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HR084_16910	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HR084_16915	COG2217	Heavy metal translocating P-type atpase
HR084_16920	COG2217	Heavy metal translocating P-type atpase
HR084_16925	COG2608	mercury ion transmembrane transporter activity
HR084_16930	COG1937	Protein conserved in bacteria
HR084_16935	COG0673	inositol 2-dehydrogenase activity
HR084_16940	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HR084_16945	COG1289	transmembrane transporter activity
HR084_16955	COG2076	Multidrug Resistance protein
HR084_16960	COG1309	transcriptional regulator
HR084_16965	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_16975	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HR084_16980	COG0557	exoribonuclease II activity
HR084_16985	COG1647	Serine aminopeptidase, S33
HR084_16990	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HR084_16995	COG0596	Alpha beta hydrolase
HR084_17000	COG1476	TRANSCRIPTIONal
HR084_17005	COG1396	sequence-specific DNA binding
HR084_17010	COG1396	sequence-specific DNA binding
HR084_17015	COG1733	regulation of RNA biosynthetic process
HR084_17020	COG0840	transmembrane signaling receptor activity
HR084_17025	COG1174	glycine betaine transport
HR084_17030	COG1732	Glycine betaine
HR084_17035	COG1174	glycine betaine transport
HR084_17040	COG0517	IMP dehydrogenase activity
HR084_17040	COG1125	glycine betaine transport
HR084_17045	COG1510	regulation of RNA biosynthetic process
HR084_17050	COG1174	glycine betaine transport
HR084_17055	COG1732	Glycine betaine
HR084_17060	COG1174	glycine betaine transport
HR084_17065	COG0517	IMP dehydrogenase activity
HR084_17065	COG1125	glycine betaine transport
HR084_17070	COG1510	regulation of RNA biosynthetic process
HR084_17075	COG2095	MarC family integral membrane protein
HR084_17085	COG3064	Membrane
HR084_17090	COG4640	response to antibiotic
HR084_17095	COG0456	acetyltransferase
HR084_17100	COG0148	phosphopyruvate hydratase activity
HR084_17105	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HR084_17110	COG0149	triose-phosphate isomerase activity
HR084_17115	COG0126	phosphoglycerate kinase activity
HR084_17120	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HR084_17125	COG2390	Transcriptional regulator
HR084_17130	COG2814	Major facilitator Superfamily
HR084_17135	COG1609	Transcriptional regulator
HR084_17140	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HR084_17145	COG0583	DNA-binding transcription factor activity
HR084_17150	COG0697	spore germination
HR084_17155	COG1113	amino acid transport
HR084_17160	COG3858	chitin binding
HR084_17165	COG1556	Lactate utilization protein
HR084_17170	COG1139	Iron-sulfur cluster binding protein
HR084_17175	COG0247	lactate metabolic process
HR084_17180	COG2197	response regulator
HR084_17185	COG4585	Histidine kinase
HR084_17190	COG0842	Transport permease protein
HR084_17195	COG1131	(ABC) transporter
HR084_17200	COG0596	Alpha beta hydrolase
HR084_17205	COG2208	phosphoserine phosphatase activity
HR084_17210	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HR084_17215	COG1874	Beta-galactosidase
HR084_17220	COG3833	ABC-type maltose transport systems, permease component
HR084_17225	COG1175	transmembrane transport
HR084_17230	COG2182	Extracellular solute-binding protein
HR084_17235	COG1609	Transcriptional regulator
HR084_17240	COG2186	Transcriptional regulator
HR084_17245	COG1620	l-lactate permease
HR084_17250	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HR084_17260	COG5039	Polysaccharide pyruvyl transferase
HR084_17265	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HR084_17270	COG0110	maltose O-acetyltransferase activity
HR084_17275	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HR084_17280	COG2244	polysaccharide biosynthetic process
HR084_17285	COG1216	Glycosyl transferase, family 2
HR084_17290	COG5039	Polysaccharide pyruvyl transferase
HR084_17295	COG1216	Glycosyl transferase, family 2
HR084_17305	COG0438	transferase activity, transferring glycosyl groups
HR084_17310	COG1215	transferase activity, transferring glycosyl groups
HR084_17315	COG0438	transferase activity, transferring glycosyl groups
HR084_17320	COG1086	Polysaccharide biosynthesis protein
HR084_17325	COG0489	protein tyrosine kinase activity
HR084_17330	COG3944	biosynthesis protein
HR084_17335	COG1396	sequence-specific DNA binding
HR084_17340	COG2272	Belongs to the type-B carboxylesterase lipase family
HR084_17350	COG3479	Phenolic acid decarboxylase
HR084_17360	COG1794	racemase activity, acting on amino acids and derivatives
HR084_17365	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HR084_17370	COG1621	beta-fructofuranosidase activity
HR084_17375	COG1621	beta-fructofuranosidase activity
HR084_17380	COG0531	amino acid
HR084_17385	COG1309	transcriptional regulator
HR084_17390	COG2076	Multidrug Resistance protein
HR084_17395	COG2076	Multidrug Resistance protein
HR084_17405	COG0277	FAD linked oxidase domain protein
HR084_17410	COG3621	Patatin-like phospholipase
HR084_17420	COG0740	serine-type endopeptidase activity
HR084_17425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HR084_17430	COG0366	Alpha amylase catalytic
HR084_17435	COG1554	hydrolase, family 65, central catalytic
HR084_17440	COG5521	maltodextrose utilization protein MalA
HR084_17445	COG3833	ABC-type maltose transport systems, permease component
HR084_17450	COG1175	transmembrane transport
HR084_17455	COG2182	Extracellular solute-binding protein
HR084_17460	COG0366	Alpha amylase catalytic
HR084_17465	COG1609	Transcriptional regulator
HR084_17470	COG1611	Belongs to the LOG family
HR084_17475	COG1694	Mazg nucleotide pyrophosphohydrolase
HR084_17480	COG0659	secondary active sulfate transmembrane transporter activity
HR084_17485	COG0288	reversible hydration of carbon dioxide
HR084_17490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HR084_17495	COG0577	efflux transmembrane transporter activity
HR084_17500	COG1136	(ABC) transporter
HR084_17505	COG5002	protein histidine kinase activity
HR084_17510	COG0745	RESPONSE REGULATOR receiver
HR084_17520	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HR084_17525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HR084_17530	COG1481	regulation of sporulation
HR084_17535	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HR084_17540	COG1660	Displays ATPase and GTPase activities
HR084_17545	COG1051	belongs to the nudix hydrolase family
HR084_17550	COG0492	ferredoxin-NADP+ reductase activity
HR084_17555	COG3883	PFAM NLP P60 protein
HR084_17555	COG0791	NLP P60 protein
HR084_17560	COG0457	Tetratricopeptide repeat
HR084_17565	COG1132	(ABC) transporter
HR084_17585	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HR084_17585	COG0140	phosphoribosyl-ATP diphosphatase activity
HR084_17590	COG0107	imidazoleglycerol-phosphate synthase activity
HR084_17595	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HR084_17600	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HR084_17605	COG0131	Imidazoleglycerol-phosphate dehydratase
HR084_17610	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HR084_17615	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HR084_17620	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HR084_17625	COG4990	cell redox homeostasis
HR084_17630	COG5297	Belongs to the glycosyl hydrolase family 6
HR084_17635	COG0110	maltose O-acetyltransferase activity
HR084_17640	COG0546	phosphoglycolate phosphatase activity
HR084_17645	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HR084_17650	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HR084_17655	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HR084_17660	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HR084_17665	COG0363	glucosamine-6-phosphate deaminase activity
HR084_17670	COG2188	Transcriptional regulator
HR084_17675	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HR084_17680	COG1846	Transcriptional regulator
HR084_17685	COG2124	cytochrome p450
HR084_17695	COG1846	Transcriptional regulator
HR084_17700	COG2814	Major facilitator Superfamily
HR084_17705	COG1950	PFAM Membrane protein of
HR084_17710	COG1983	PspC domain protein
HR084_17715	COG3595	metallopeptidase activity
HR084_17730	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HR084_17735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HR084_17740	COG0556	nucleotide-excision repair
HR084_17745	COG4897	Protein conserved in bacteria
HR084_17750	COG0574	Belongs to the PEP-utilizing enzyme family
HR084_17750	COG3848	Pyruvate phosphate dikinase
HR084_17755	COG1309	transcriptional regulator
HR084_17760	COG2814	Major facilitator Superfamily
HR084_17765	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HR084_17775	COG0793	Belongs to the peptidase S41A family
HR084_17775	COG3409	Peptidoglycan-binding domain 1 protein
HR084_17780	COG2177	Part of the ABC transporter FtsEX involved in
HR084_17785	COG2884	Cell division ATP-binding protein ftsE
HR084_17790	COG2010	Cytochrome c
HR084_17795	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HR084_17805	COG0653	protein targeting
HR084_17810	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HR084_17825	COG1516	flagellar protein fliS
HR084_17830	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HR084_17835	COG1334	flagellar protein FlaG
HR084_17840	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HR084_17845	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HR084_17850	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HR084_17860	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HR084_17865	COG4786	Flagellar basal body rod
HR084_17865	COG1256	bacterial-type flagellum assembly
HR084_17870	COG3418	PFAM FlgN family protein
HR084_17875	COG2747	anti-sigma28 factor FlgM
HR084_17885	COG1040	competence protein
HR084_17895	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HR084_17900	COG1307	EDD domain protein, DegV family
HR084_17905	COG2197	response regulator
HR084_17910	COG4585	Histidine kinase
HR084_17915	COG1739	Uncharacterized protein family UPF0029
HR084_17920	COG1316	TRANSCRIPTIONal
HR084_17925	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HR084_17930	COG0438	transferase activity, transferring glycosyl groups
HR084_17935	COG1215	transferase activity, transferring glycosyl groups
HR084_17940	COG3206	protein involved in exopolysaccharide biosynthesis
HR084_17945	COG3307	-O-antigen
HR084_17950	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HR084_17955	COG0438	transferase activity, transferring glycosyl groups
HR084_17955	COG0297	glycogen (starch) synthase activity
HR084_17960	COG2244	polysaccharide biosynthetic process
HR084_17975	COG0860	N-Acetylmuramoyl-L-alanine amidase
HR084_17975	COG2247	cell wall binding repeat
HR084_17980	COG2385	sporulation resulting in formation of a cellular spore
HR084_17980	COG2247	cell wall binding repeat
HR084_17990	COG1316	TRANSCRIPTIONal
HR084_17995	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HR084_18015	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HR084_18020	COG1134	teichoic acid transport
HR084_18025	COG1682	transport, permease protein
HR084_18040	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HR084_18040	COG1215	transferase activity, transferring glycosyl groups
HR084_18045	COG0463	Glycosyl transferase, family 2
HR084_18090	COG4193	domain, Protein
HR084_18095	COG1482	cell wall glycoprotein biosynthetic process
HR084_18100	COG0697	spore germination
HR084_18105	COG0814	amino acid
HR084_18115	COG2814	Major facilitator Superfamily
HR084_18120	COG1316	TRANSCRIPTIONal
HR084_18125	COG0561	phosphatase activity
HR084_18130	COG0791	NLP P60 protein
HR084_18140	COG2843	Capsule synthesis protein
HR084_18150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HR084_18155	COG1609	Transcriptional regulator
HR084_18160	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HR084_18165	COG1869	D-ribose catabolic process
HR084_18170	COG1129	ABC transporter
HR084_18175	COG1172	Belongs to the binding-protein-dependent transport system permease family
HR084_18180	COG1879	ABC-type sugar transport system periplasmic component
HR084_18185	COG3103	Sh3 type 3 domain protein
HR084_18195	COG2249	NAD(P)H dehydrogenase (quinone) activity
HR084_18200	COG3527	Alpha-acetolactate decarboxylase
HR084_18205	COG0028	Belongs to the TPP enzyme family
HR084_18210	COG0583	DNA-binding transcription factor activity
HR084_18215	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HR084_18230	COG5337	Spore coat protein CotH
HR084_18240	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HR084_18250	COG0405	Gamma-glutamyltransferase
HR084_18255	COG1522	sequence-specific DNA binding
HR084_18260	COG2059	Chromate
HR084_18265	COG2059	Chromate
HR084_18275	COG0655	NAD(P)H dehydrogenase (quinone) activity
HR084_18280	COG0583	DNA-binding transcription factor activity
HR084_18310	COG5444	nuclease activity
HR084_18330	COG3878	Protein conserved in bacteria
HR084_18335	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HR084_18340	COG4464	protein tyrosine phosphatase activity
HR084_18345	COG0489	protein tyrosine kinase activity
HR084_18350	COG3944	biosynthesis protein
HR084_18360	COG4715	Zinc finger, swim domain protein
HR084_18365	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HR084_18370	COG0561	phosphatase activity
HR084_18375	COG1349	DNA-binding transcription factor activity
HR084_18380	COG0629	single-stranded DNA binding
HR084_18395	COG3764	Sortase (surface protein transpeptidase)
HR084_18405	COG0745	RESPONSE REGULATOR receiver
HR084_18405	COG2972	Histidine kinase
HR084_18410	COG1970	mechanosensitive ion channel activity
HR084_18415	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HR084_18420	COG0457	Tetratricopeptide repeat
HR084_18425	COG4786	Flagellar basal body rod
HR084_18430	COG4786	Flagellar basal body rod
HR084_18435	COG1077	Cell shape determining protein MreB Mrl
HR084_18440	COG1609	Transcriptional regulator
HR084_18450	COG1846	Transcriptional regulator
HR084_18455	COG2814	Major facilitator Superfamily
HR084_18460	COG3420	alginic acid biosynthetic process
HR084_18465	COG1953	Uracil, thiamine, allantoin
HR084_18470	COG0477	Major facilitator Superfamily
HR084_18475	COG1335	isochorismatase
HR084_18485	COG0004	ammonium transporteR
HR084_18490	COG0347	Belongs to the P(II) protein family
HR084_18495	COG0671	phosphoesterase, PA-phosphatase related
HR084_18505	COG0739	heme binding
HR084_18510	COG1247	-acetyltransferase
HR084_18530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HR084_18535	COG0789	Transcriptional regulator
HR084_18545	COG2910	NAD(P)H-binding
HR084_18550	COG1959	2 iron, 2 sulfur cluster binding
HR084_18555	COG0804	urea catabolic process
HR084_18560	COG0832	Belongs to the urease beta subunit family
HR084_18565	COG0831	urea catabolic process
HR084_18580	COG3237	CsbD-like
HR084_18585	COG1994	Peptidase M50
HR084_18590	COG0457	Tetratricopeptide repeat
HR084_18595	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HR084_18600	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HR084_18610	COG2304	oxidoreductase activity
HR084_18620	COG2304	oxidoreductase activity
HR084_18625	COG2385	sporulation resulting in formation of a cellular spore
HR084_18630	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HR084_18640	COG4836	Membrane
HR084_18650	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HR084_18655	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HR084_18660	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HR084_18665	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HR084_18670	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HR084_18675	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HR084_18685	COG0356	it plays a direct role in the translocation of protons across the membrane
HR084_18695	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HR084_18700	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HR084_18705	COG4475	Protein of unknown function (DUF436)
HR084_18710	COG0698	ribose 5-phosphate isomerase
HR084_18715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HR084_18720	COG1971	Probably functions as a manganese efflux pump
HR084_18725	COG0009	L-threonylcarbamoyladenylate synthase
HR084_18730	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HR084_18750	COG2890	protein-(glutamine-N5) methyltransferase activity
HR084_18755	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HR084_18760	COG0346	lactoylglutathione lyase activity
HR084_18765	COG0789	Transcriptional regulator
HR084_18770	COG0679	Auxin Efflux Carrier
HR084_18775	COG0281	malic enzyme
HR084_18780	COG1435	thymidine kinase activity
HR084_18790	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HR084_18800	COG1494	fructose-1,6-bisphosphatase
HR084_18805	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HR084_18810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HR084_18815	COG0191	fructose-bisphosphate aldolase activity
HR084_18820	COG2204	response regulator
HR084_18825	COG4821	SIS domain
HR084_18830	COG0504	CTP synthase activity
HR084_18835	COG3343	RNA polymerase activity
HR084_18840	COG1960	acyl-CoA dehydrogenase activity
HR084_18845	COG0247	lactate metabolic process
HR084_18845	COG2181	nitrate reductase activity
HR084_18850	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HR084_18855	COG4294	response to UV
HR084_18865	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HR084_18870	COG1132	(ABC) transporter
HR084_18875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HR084_18885	COG2181	nitrate reductase activity
HR084_18890	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HR084_18895	COG1140	nitrate reductase beta subunit
HR084_18900	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HR084_18905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HR084_18915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HR084_18920	COG2223	nitrite transmembrane transporter activity
HR084_18925	COG0018	arginyl-trna synthetase
HR084_18930	COG4506	Protein conserved in bacteria
HR084_18945	COG0535	radical SAM domain protein
HR084_18955	COG1131	(ABC) transporter
HR084_18960	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HR084_18965	COG0612	Peptidase, M16
HR084_18970	COG0612	Peptidase, M16
HR084_18980	COG3391	amine dehydrogenase activity
HR084_18985	COG3391	amine dehydrogenase activity
HR084_18990	COG0457	Tetratricopeptide repeat
HR084_19020	COG1131	(ABC) transporter
HR084_19030	COG0010	Belongs to the arginase family
HR084_19035	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HR084_19040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HR084_19050	COG1994	Peptidase M50
HR084_19055	COG1942	4-Oxalocrotonate Tautomerase
HR084_19060	COG1846	Transcriptional regulator
HR084_19065	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HR084_19070	COG0477	Major facilitator Superfamily
HR084_19075	COG1959	2 iron, 2 sulfur cluster binding
HR084_19080	COG3465	dGTPase activity
HR084_19085	COG1078	dGTPase activity
HR084_19090	COG4844	belongs to the
HR084_19100	COG0697	spore germination
HR084_19105	COG0095	Lipoate-protein ligase
HR084_19110	COG0583	DNA-binding transcription factor activity
HR084_19115	COG0280	phosphate acetyltransferase
HR084_19125	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_19130	COG0436	Aminotransferase
HR084_19135	COG2814	Major facilitator Superfamily
HR084_19140	COG0151	Belongs to the GarS family
HR084_19145	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_19150	COG1917	Cupin 2, conserved barrel domain protein
HR084_19155	COG0077	Prephenate dehydratase
HR084_19160	COG2814	Major facilitator Superfamily
HR084_19165	COG0833	amino acid
HR084_19170	COG4187	Peptidase family M20/M25/M40
HR084_19175	COG1012	belongs to the aldehyde dehydrogenase family
HR084_19180	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HR084_19190	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HR084_19195	COG1091	dTDP-4-dehydrorhamnose reductase activity
HR084_19200	COG1088	dTDP-glucose 4,6-dehydratase activity
HR084_19205	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HR084_19210	COG3980	spore coat polysaccharide biosynthesis protein
HR084_19215	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HR084_19220	COG2089	acid synthase
HR084_19225	COG0456	acetyltransferase
HR084_19230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HR084_19235	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HR084_19240	COG0463	Glycosyl transferase, family 2
HR084_19250	COG2363	Small membrane protein
HR084_19255	COG2233	PERMEase
HR084_19265	COG1012	belongs to the aldehyde dehydrogenase family
HR084_19270	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HR084_19275	COG1216	Glycosyl transferase, family 2
HR084_19290	COG1695	Transcriptional regulator
HR084_19295	COG0351	phosphomethylpyrimidine kinase
HR084_19305	COG1621	beta-fructofuranosidase activity
HR084_19310	COG1263	PTS System
HR084_19310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HR084_19315	COG2116	formate transmembrane transporter activity
HR084_19320	COG3711	transcriptional antiterminator
HR084_19330	COG1404	Belongs to the peptidase S8 family
HR084_19335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HR084_19340	COG0778	Nitroreductase
HR084_19345	COG0772	Belongs to the SEDS family
HR084_19355	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HR084_19360	COG1845	cytochrome c oxidase, subunit III
HR084_19365	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HR084_19370	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HR084_19375	COG2261	transglycosylase associated protein
HR084_19380	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HR084_19385	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HR084_19390	COG2246	polysaccharide biosynthetic process
HR084_19395	COG1309	transcriptional regulator
HR084_19405	COG3162	membrane
HR084_19410	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HR084_19415	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HR084_19420	COG2837	iron assimilation
HR084_19425	COG2822	iron ion transport
HR084_19430	COG0672	)-iron permease
HR084_19435	COG0352	thiamine-phosphate diphosphorylase activity
HR084_19440	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HR084_19445	COG0583	DNA-binding transcription factor activity
HR084_19450	COG1380	Effector of murein hydrolase LrgA
HR084_19455	COG1346	cytolysis
HR084_19460	COG2814	Major facilitator Superfamily
HR084_19465	COG4895	conserved protein (DUF2196)
HR084_19470	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HR084_19475	COG0346	lactoylglutathione lyase activity
HR084_19480	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HR084_19485	COG1404	Belongs to the peptidase S8 family
HR084_19490	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HR084_19490	COG1263	PTS System
HR084_19495	COG3711	transcriptional antiterminator
HR084_19500	COG1442	glycosyl transferase family 8
HR084_19505	COG5522	Integral membrane protein (intg_mem_TP0381)
HR084_19510	COG1846	Transcriptional regulator
HR084_19515	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HR084_19520	COG2234	aminopeptidase activity
HR084_19535	COG2814	Major facilitator Superfamily
HR084_19540	COG2357	RelA SpoT domain protein
HR084_19545	COG1575	Belongs to the MenA family. Type 1 subfamily
HR084_19560	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HR084_19565	COG1696	Membrane protein involved in D-alanine export
HR084_19570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HR084_19575	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HR084_19580	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HR084_19585	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HR084_19590	COG1486	melibiose metabolic process
HR084_19595	COG1447	Phosphotransferase system cellobiose-specific component IIA
HR084_19600	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HR084_19605	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HR084_19610	COG3711	transcriptional antiterminator
HR084_19610	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HR084_19620	COG2094	Belongs to the DNA glycosylase MPG family
HR084_19625	COG0753	catalase activity
HR084_19630	COG2814	Major facilitator Superfamily
HR084_19635	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HR084_19640	COG1131	(ABC) transporter
HR084_19660	COG1595	DNA-templated transcription, initiation
HR084_19665	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HR084_19670	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HR084_19675	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HR084_19680	COG4988	ABC transporter
HR084_19685	COG1294	oxidase, subunit
HR084_19690	COG1271	oxidase subunit
HR084_19695	COG3493	citrate carrier protein
HR084_19700	COG0501	Belongs to the peptidase M48B family
HR084_19710	COG0726	polysaccharide deacetylase
HR084_19715	COG3842	ATPase activity
HR084_19720	COG2508	Transcriptional regulator
HR084_19725	COG1012	belongs to the aldehyde dehydrogenase family
HR084_19730	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HR084_19740	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HR084_19750	COG4585	Histidine kinase
HR084_19755	COG2197	response regulator
HR084_19760	COG2195	Cleaves the N-terminal amino acid of tripeptides
HR084_19770	COG4894	glucomannan catabolic process
HR084_19775	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HR084_19780	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HR084_19785	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_19790	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HR084_19795	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HR084_19800	COG2610	gluconate transmembrane transporter activity
HR084_19805	COG0500	methyltransferase
HR084_19810	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HR084_19825	COG0693	protein deglycase activity
HR084_19825	COG0753	catalase activity
HR084_19830	COG2851	Citrate transporter
HR084_19835	COG2273	Hydrolase Family 16
HR084_19840	COG3711	transcriptional antiterminator
HR084_19850	COG2270	Major facilitator Superfamily
HR084_19855	COG0513	Belongs to the DEAD box helicase family
HR084_19860	COG2755	lipolytic protein G-D-S-L family
HR084_19860	COG3401	FG-GAP repeat protein
HR084_19920	COG3209	COG3209 Rhs family protein
HR084_19925	COG0697	spore germination
HR084_19930	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_19940	COG0589	response to stress
HR084_19945	COG2723	6-phospho-beta-galactosidase activity
HR084_19950	COG2190	(PTS) system
HR084_19950	COG1263	PTS System
HR084_19950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HR084_19965	COG5444	nuclease activity
HR084_19980	COG3507	Belongs to the glycosyl hydrolase 43 family
HR084_19990	COG2986	histidine ammonia-lyase
HR084_19995	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HR084_20000	COG1228	amidohydrolase
HR084_20005	COG0010	Belongs to the arginase family
HR084_20010	COG0833	amino acid
HR084_20015	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HR084_20020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HR084_20025	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HR084_20030	COG2390	Transcriptional regulator
HR084_20040	COG3192	ethanolamine utilization protein
HR084_20045	COG2079	MmgE PrpD family protein
HR084_20050	COG1473	amidohydrolase
HR084_20055	COG1126	abc transporter atp-binding protein
HR084_20060	COG0765	amino acid transport
HR084_20065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HR084_20070	COG0456	acetyltransferase
HR084_20075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HR084_20085	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HR084_20090	COG0561	phosphatase activity
HR084_20120	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HR084_20125	COG5294	Protein conserved in bacteria
HR084_20130	COG0577	efflux transmembrane transporter activity
HR084_20135	COG1136	(ABC) transporter
HR084_20140	COG2205	protein histidine kinase activity
HR084_20145	COG0745	RESPONSE REGULATOR receiver
HR084_20150	COG0191	fructose-bisphosphate aldolase activity
HR084_20155	COG1082	Xylose isomerase domain protein TIM barrel
HR084_20160	COG1082	Xylose isomerase domain protein TIM barrel
HR084_20165	COG0673	inositol 2-dehydrogenase activity
HR084_20170	COG2814	Major facilitator Superfamily
HR084_20175	COG1082	Xylose isomerase domain protein TIM barrel
HR084_20180	COG3962	Belongs to the TPP enzyme family
HR084_20185	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HR084_20195	COG1012	belongs to the aldehyde dehydrogenase family
HR084_20200	COG1349	DNA-binding transcription factor activity
HR084_20205	COG0667	Aldo Keto reductase
HR084_20220	COG2814	Major facilitator Superfamily
HR084_20225	COG0326	Molecular chaperone. Has ATPase activity
HR084_20235	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_20240	COG1309	transcriptional regulator
HR084_20245	COG1012	belongs to the aldehyde dehydrogenase family
HR084_20250	COG0456	acetyltransferase
HR084_20255	COG2850	peptidyl-arginine hydroxylation
HR084_20260	COG2226	methyltransferase
HR084_20275	COG0367	asparagine synthase
HR084_20280	COG2814	Major facilitator Superfamily
HR084_20285	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HR084_20295	COG1714	RDD family
HR084_20300	COG2311	Membrane
HR084_20305	COG1917	Cupin 2, conserved barrel domain protein
HR084_20310	COG1309	transcriptional regulator
HR084_20315	COG1028	Short-chain dehydrogenase reductase Sdr
HR084_20320	COG1846	Transcriptional regulator
HR084_20325	COG1380	Effector of murein hydrolase LrgA
HR084_20330	COG1346	cytolysis
HR084_20335	COG5039	Polysaccharide pyruvyl transferase
HR084_20340	COG1929	Belongs to the glycerate kinase type-1 family
HR084_20345	COG1802	Transcriptional regulator
HR084_20350	COG1070	Carbohydrate kinase
HR084_20355	COG2610	gluconate transmembrane transporter activity
HR084_20360	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HR084_20365	COG0450	alkyl hydroperoxide reductase
HR084_20370	COG3634	alkyl hydroperoxide reductase activity
HR084_20375	COG2723	6-phospho-beta-galactosidase activity
HR084_20385	COG2188	Transcriptional regulator
HR084_20400	COG1131	(ABC) transporter
HR084_20405	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HR084_20440	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HR084_20455	COG1063	alcohol dehydrogenase
HR084_20475	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HR084_20480	COG0456	acetyltransferase
HR084_20485	COG0457	Tetratricopeptide repeat
HR084_20495	COG0010	Belongs to the arginase family
HR084_20500	COG0833	amino acid
HR084_20505	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HR084_20510	COG3829	transcription factor binding
HR084_20515	COG5002	protein histidine kinase activity
HR084_20540	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HR084_20545	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HR084_20550	COG4853	Protein conserved in bacteria
HR084_20555	COG4863	YycH protein
HR084_20560	COG5002	protein histidine kinase activity
HR084_20565	COG0745	RESPONSE REGULATOR receiver
HR084_20595	COG0346	lactoylglutathione lyase activity
HR084_20600	COG0305	Participates in initiation and elongation during chromosome replication
HR084_20615	COG3093	addiction module antidote protein HigA
HR084_20620	COG2807	transmembrane transport
HR084_20625	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HR084_20630	COG0359	binds to the 23S rRNA
HR084_20635	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HR084_20640	COG4241	membrane
HR084_20650	COG5577	PFAM Coat F domain
HR084_20655	COG1733	regulation of RNA biosynthetic process
HR084_20660	COG1227	inorganic diphosphatase activity
HR084_20675	COG2271	Major facilitator Superfamily
HR084_20680	COG0789	Transcriptional regulator
HR084_20680	COG4978	Transcriptional regulator
HR084_20690	COG4319	ketosteroid isomerase
HR084_20695	COG1357	PFAM Pentapeptide repeats (8 copies)
HR084_20700	COG2814	Major facilitator Superfamily
HR084_20705	COG0583	DNA-binding transcription factor activity
HR084_20710	COG2153	protein acetylation
HR084_20720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HR084_20725	COG1846	Transcriptional regulator
HR084_20730	COG2153	protein acetylation
HR084_20735	COG2364	Membrane
HR084_20740	COG0456	acetyltransferase
HR084_20745	COG2315	Protein conserved in bacteria
HR084_20750	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HR084_20760	COG2814	Major facilitator Superfamily
HR084_20770	COG1331	Highly conserved protein containing a thioredoxin domain
HR084_20775	COG1266	CAAX protease self-immunity
HR084_20780	COG0477	Major facilitator Superfamily
HR084_20780	COG2814	Major facilitator Superfamily
HR084_20785	COG0110	maltose O-acetyltransferase activity
HR084_20790	COG0346	lactoylglutathione lyase activity
HR084_20795	COG1609	Transcriptional regulator
HR084_20800	COG0708	Exodeoxyribonuclease III
HR084_20805	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HR084_20810	COG0629	single-stranded DNA binding
HR084_20815	COG0360	Binds together with S18 to 16S ribosomal RNA
HR084_20820	COG0012	GTP binding
HR084_20825	COG0243	molybdopterin cofactor binding
HR084_20830	COG4481	Protein conserved in bacteria
HR084_20835	COG3949	Membrane
HR084_20845	COG1475	DNA binding
HR084_20850	COG1192	Involved in chromosome partitioning
HR084_20860	COG1475	DNA binding
HR084_20865	COG0357	Ribosomal RNA small subunit methyltransferase G
HR084_20870	COG0445	tRNA wobble uridine modification
HR084_20875	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HR084_20880	COG1847	R3H domain protein
HR084_20885	COG0706	membrane insertase activity
HR084_20890	COG0594	ribonuclease P activity