locus-tag class description HT135_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HT135_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HT135_00015 ENOG410848D S4 domain protein YaaA HT135_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HT135_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HT135_00075 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HT135_00085 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HT135_00090 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HT135_00095 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HT135_00105 ENOG4105ZMH deoxynucleoside kinase HT135_00115 ENOG4105VRS hydrolase family 18 HT135_00120 ENOG4105GTG Isochorismatase HT135_00125 ENOG4108Z6B deaminase HT135_00135 ENOG4105C6E dna polymerase iii HT135_00140 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HT135_00145 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HT135_00155 ENOG41067KS pro-sigma K processing HT135_00195 ENOG4105CDW Resistance protein HT135_00200 ENOG4105CXN decarboxylase HT135_00205 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HT135_00210 ENOG4105X0R protein from nitrogen regulatory protein P-II HT135_00215 ENOG4105XVJ Protein of unknown function (DUF327) HT135_00220 ENOG4105FA2 dna polymerase iii HT135_00225 ENOG4105MA4 psp1 domain protein HT135_00235 ENOG41060K3 Methyltransferase HT135_00240 ENOG4105VC4 domain protein HT135_00245 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HT135_00250 ENOG4105KRN Transcriptional regulator, abrb family HT135_00255 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HT135_00260 ENOG4105F8V Hydrolase, tatD family HT135_00265 ENOG41069ER domain protein HT135_00275 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HT135_00280 ENOG4105XFA sporulation peptidase YabG HT135_00285 ENOG4105W42 Veg protein HT135_00290 ENOG4105XEW small acid-soluble spore protein HT135_00295 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HT135_00300 ENOG4105DFT pur operon repressor HT135_00305 ENOG4105KME endoribonuclease L-psp HT135_00310 ENOG4105K4W Could be involved in septation (By similarity) HT135_00315 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HT135_00320 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HT135_00325 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HT135_00330 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HT135_00340 ENOG4108JA2 transcriptioN-repair coupling factor HT135_00345 ENOG4108M14 stage v sporulation protein t HT135_00355 ENOG4108IY2 MazG family HT135_00360 ENOG41082I2 s4 domain protein HT135_00365 ENOG4105VYY sporulation protein yabp HT135_00380 ENOG41060GV RNA binding s1 domain protein HT135_00410 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HT135_00415 ENOG4108UGV hypoxanthine phosphoribosyltransferase HT135_00420 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HT135_00430 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) HT135_00435 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase HT135_00440 ENOG4105C6T cysteine synthase HT135_00445 ENOG4105CRQ synthase (Component I) HT135_00450 ENOG4105DDQ anthranilate synthase HT135_00455 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 HT135_00460 ENOG4105EEI dihydropteroate synthase HT135_00465 ENOG4105KRF dihydroneopterin aldolase HT135_00470 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HT135_00480 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HT135_00485 ENOG4105CRK lysyL-tRNA synthetase HT135_00570 ENOG4108Z0C Uvrb UvrC protein HT135_00575 ENOG41066A3 ATP guanido phosphotransferase HT135_00585 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HT135_00590 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HT135_00595 ENOG4105CTP PilT protein domain protein HT135_00600 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) HT135_00605 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HT135_00610 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HT135_00615 ENOG4105D7W serine acetyltransferase HT135_00620 ENOG4105C8N cysteinyl-tRNA synthetase HT135_00625 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) HT135_00630 ENOG4105C2N RNA methyltransferase TrmH family group 3 HT135_00635 ENOG4105M0M Tetracycline resistance protein HT135_00655 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HT135_00670 ENOG4108VZM 50s ribosomal protein L10 HT135_00680 ENOG4107Y49 methyltransferase HT135_00685 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HT135_00690 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HT135_00695 ENOG4105XPM ribosomal protein HT135_00700 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HT135_00705 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) HT135_00710 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HT135_00715 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HT135_00720 ENOG4107SKW Inherit from COG: Alpha beta hydrolase HT135_00725 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HT135_00730 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HT135_00735 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HT135_00745 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HT135_00760 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HT135_00765 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HT135_00775 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HT135_00780 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) HT135_00790 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HT135_00800 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HT135_00805 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HT135_00810 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HT135_00815 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HT135_00825 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HT135_00830 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HT135_00840 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HT135_00850 ENOG41067V7 50S ribosomal protein L36 HT135_00855 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HT135_00860 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HT135_00865 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HT135_00870 ENOG4108ZT0 50S ribosomal protein l17 HT135_00875 ENOG4108JJB ABC transporter HT135_00880 ENOG4108JJB ABC transporter HT135_00885 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HT135_00890 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HT135_00895 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HT135_00900 ENOG4108UJD 30S ribosomal protein S9 HT135_00905 ENOG4108I0C methyltransferase HT135_00920 ENOG4105D1F ATP-binding protein HT135_00935 ENOG4108NMV polysaccharide deacetylase HT135_01015 ENOG4105CHH sulfate transporter HT135_01025 ENOG4108SA1 esterase HT135_01045 ENOG410874W AraC family transcriptional regulator HT135_01050 ENOG4105EHZ conserved protein UCP016719 HT135_01055 ENOG4105D17 glycoside hydrolase, family 3 domain protein HT135_01075 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HT135_01085 ENOG4105EWC Purine nucleoside phosphorylase HT135_01115 ENOG4105EMN RNA polymerase sigma factor HT135_01125 ENOG4105C8B TIGR00159 family HT135_01130 ENOG4107U5W ybbr family HT135_01135 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HT135_01145 ENOG4108TWJ NADH dehydrogenase subunit 5 HT135_01165 ENOG4105GPN Uncharacterized conserved protein (DUF2294) HT135_01170 ENOG4105WAB arsR family transcriptional regulator HT135_01175 ENOG4108RWP Major Facilitator Superfamily protein HT135_01210 ENOG4105G0J serine threonine protein kinase HT135_01220 ENOG4106K80 HT135_01230 ENOG4106DDH Sporulation-specific SASP protein HT135_01240 ENOG4108HWY Beta-lactamase HT135_01245 ENOG4107E6A Cytochrome p-450 HT135_01255 ENOG4107QTZ amino acid HT135_01260 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HT135_01265 ENOG4105CXY transporter HT135_01275 ENOG410645S MarR family Transcriptional regulator HT135_01280 ENOG4105DCM major facilitator superfamily HT135_01290 ENOG410631K Membrane HT135_01295 ENOG4106AXJ AraC family transcriptional regulator HT135_01300 ENOG4107SCQ Iron-containing alcohol dehydrogenase HT135_01305 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HT135_01310 ENOG4108TCS Glutamyl endopeptidase HT135_01320 ENOG4108WC5 Alpha Beta Hydrolase Fold protein HT135_01325 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HT135_01330 ENOG4107ZTW SNARE associated Golgi HT135_01355 ENOG4105C72 UPF0176 protein HT135_01365 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane HT135_01370 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HT135_01385 ENOG4105CM2 brancheD-chain amino acid aminotransferase HT135_01390 ENOG4108IQI permease HT135_01395 ENOG4108J5H Homocysteine s-methyltransferase HT135_01405 ENOG4105CSV Glutaminase HT135_01420 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase HT135_01425 ENOG4105C26 Dehydrogenase HT135_01430 ENOG4105DJB Major Facilitator Superfamily HT135_01435 ENOG4105EQX glucarate dehydratase HT135_01440 ENOG41073TP transcriptional regulator HT135_01445 ENOG4105CTX dehydratase HT135_01460 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HT135_01495 ENOG4105MUA Resistance protein HT135_01505 ENOG4105DGI Alkaline phosphatase HT135_01510 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HT135_01515 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HT135_01520 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) HT135_01525 ENOG4107EPV Aminotransferase class V HT135_01530 ENOG4105C0R drug resistance transporter emrb qaca subfamily HT135_01535 ENOG4105J7D transcriptional regulator HT135_01540 ENOG4107RB3 L-asparaginase HT135_01545 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold HT135_01555 ENOG41060AI SEC-C motif HT135_01565 ENOG4107Y7X LytTR HT135_01570 ENOG4108IUW ABC transporter HT135_01575 ENOG4108SDH ABC, transporter HT135_01580 ENOG4107SET aldo keto reductase HT135_01615 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HT135_01625 ENOG4105DSE periplasmic solute binding protein HT135_01630 ENOG4105DIK (ABC) transporter HT135_01640 ENOG4105DEN Luciferase family HT135_01645 ENOG4108N0M stress protein HT135_01650 ENOG4106FN3 tellurium resistance protein HT135_01655 ENOG4106FN3 tellurium resistance protein HT135_01660 ENOG4107TS3 membrane protein, TerC HT135_01675 ENOG4105DAX Pfam:DUF2983 HT135_01685 ENOG4108TTB tellurium resistance protein HT135_01695 ENOG41079KZ Major Facilitator Superfamily HT135_01700 ENOG4107XZQ multidrug resistance protein HT135_01705 ENOG4108A65 Transcriptional regulator HT135_01710 ENOG4108IJ7 Glycine betaine HT135_01715 ENOG4107SQ8 Glycine betaine HT135_01745 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HT135_01785 ENOG4105EIG urea carboxylase-associated protein 1 HT135_01790 ENOG4107RA1 nh(3)-dependent nad( ) synthetase HT135_01795 ENOG4105I1F Resistance protein HT135_01805 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HT135_01810 ENOG41089UC methyltransferase, type 11 HT135_01815 ENOG4105C5Q Transcriptional regulator HT135_01820 ENOG4105I82 acetyl xylan esterase HT135_01825 ENOG410756H nucleotidyltransferase HT135_01835 ENOG4105C26 Dehydrogenase HT135_01840 ENOG4105CK7 Sodium proline symporter HT135_01845 ENOG4107YHD transcriptional regulator HT135_01855 ENOG4108PJD permease HT135_01865 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HT135_01870 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HT135_01875 ENOG4108IFG nitrite reductase, (NAD(P)H) HT135_01880 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HT135_01900 ENOG4105S7A ErfK ybiS ycfS ynhG family protein HT135_01910 ENOG4105CKI cobalamin synthesis protein HT135_01915 ENOG4105E5Q amino acid AbC transporter HT135_01920 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein HT135_01925 ENOG4105E2A Dehydrogenase HT135_01930 ENOG4105HHM rdd domain containing protein HT135_01940 ENOG4108VEN abc transporter atp-binding protein HT135_01945 ENOG4105CS2 ec 3.2.1.21 HT135_01960 ENOG4105C8Q Methyl-accepting chemotaxis HT135_01965 ENOG41080HJ 6-phospho 3-hexuloisomerase HT135_01970 ENOG4108VA3 3-hexulose-6-phosphate synthase HT135_01975 ENOG4105KVH Transcriptional regulator HT135_01980 ENOG4105CEY Amp-dependent synthetase and ligase HT135_02010 ENOG4105SX7 Transporter HT135_02030 ENOG4105CDA abc transporter atp-binding protein HT135_02035 ENOG4105DRP amino acid AbC transporter HT135_02045 ENOG4106P55 Transcriptional regulator HT135_02050 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HT135_02055 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HT135_02060 ENOG41069ZX HT135_02065 ENOG41069ZX HT135_02075 ENOG4105DUX Transporter HT135_02090 ENOG4105E1K spore germination protein HT135_02110 ENOG4107WD8 ABC transporter, permease HT135_02115 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HT135_02120 ENOG4105BZU Histidine kinase HT135_02145 ENOG4105CFH Aspartokinase HT135_02150 ENOG4105DHS permease protein HT135_02155 ENOG4105CM4 permease protein HT135_02160 ENOG4108IPW abc transporter atp-binding protein HT135_02175 ENOG4105R8C Transcriptional regulator HT135_02180 ENOG4108DBC nitroreductase HT135_02185 ENOG41067V3 Antibiotic biosynthesis monooxygenase HT135_02190 ENOG4105YVS arsR family transcriptional regulator HT135_02200 ENOG4108JPW Aminotransferase HT135_02205 ENOG4105C26 Dehydrogenase HT135_02215 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HT135_02220 ENOG4105KTB nuclear export factor GLE1 HT135_02225 ENOG4108T5E Copper resistance protein HT135_02230 ENOG4108ZYE Transcriptional regulator HT135_02255 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HT135_02280 ENOG4105E7W lamb ycsf family protein HT135_02285 ENOG4105C5A transporter HT135_02290 ENOG4105CFM UPF0317 protein HT135_02295 ENOG4105P4J Allophanate hydrolase, subunit 1 HT135_02305 ENOG4107258 Transcriptional regulator HT135_02310 ENOG4105XJB lipolytic protein G-D-S-L family HT135_02320 ENOG41061CK Antibiotic biosynthesis monooxygenase HT135_02325 ENOG4107RVG penicillin-binding protein HT135_02330 ENOG4107QM2 Aldo Keto reductase HT135_02335 ENOG4105ETD TRANSCRIPTIONal HT135_02345 ENOG4105HMZ Methyltransferase HT135_02350 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HT135_02365 ENOG410606W general stress protein HT135_02375 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HT135_02380 ENOG4105VCH membrane HT135_02390 ENOG4105C9U ATP-dependent DNA helicase RecQ HT135_02405 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) HT135_02410 ENOG4107R8N Glycosyl transferase, family 2 HT135_02420 ENOG4105C0X amino acid HT135_02440 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HT135_02445 ENOG4107BMA Transglycosylase associated protein HT135_02450 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) HT135_02455 ENOG4105EU9 HT135_02460 ENOG4105QVS general stress protein HT135_02465 ENOG41082W1 Cupin 2, conserved barrel domain protein HT135_02485 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HT135_02490 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HT135_02495 ENOG4108MRH transcriptional regulatory protein HT135_02500 ENOG4107QJT sodium dicarboxylate symporter HT135_02505 ENOG4106F5Q Membrane HT135_02515 ENOG4105CJ1 ABC, transporter HT135_02530 ENOG4105FDT acyl-CoA dehydrogenase HT135_02550 ENOG4105SZ6 Thioredoxin HT135_02555 ENOG4105CPF Cell wall formation (By similarity) HT135_02560 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HT135_02565 ENOG4105C1J atp-dependent rna helicase HT135_02570 ENOG410905X membrane-flanked domain protein HT135_02575 ENOG4105CKV Membrane HT135_02585 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HT135_02590 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein HT135_02595 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HT135_02605 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) HT135_02610 ENOG4107MMM Anti-sigma-factor antagonist HT135_02615 ENOG4105FUA antagonist HT135_02620 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HT135_02625 ENOG4107SGM protein serine threonine phosphatase HT135_02630 ENOG4105WN5 stage II sporulation protein HT135_02635 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HT135_02645 ENOG41064BQ Phosphatase HT135_02655 ENOG4105M5P UPF0310 protein HT135_02660 ENOG4105RV9 Transcriptional regulator HT135_02760 ENOG4105ECK Fatty Acid Desaturase HT135_02765 ENOG4105VEQ Cold shock protein HT135_02770 ENOG4105VEQ Cold shock protein HT135_02775 ENOG4108VJ1 Transcriptional regulator (CarD family HT135_02780 ENOG4105UNS Pfam:DUF419 HT135_02785 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase HT135_02805 ENOG4105CZ9 Domain of unknown function (DU1801) HT135_02810 ENOG4105GIG HT135_02825 ENOG4108U05 Transcriptional regulator HT135_02830 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 HT135_02850 ENOG4108V4B ThiJ pfpI HT135_02865 ENOG4105T38 integral membrane protein HT135_02870 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HT135_02875 ENOG41085FC arsR family transcriptional regulator HT135_02880 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase HT135_02910 ENOG41090E6 transcriptional regulator MERR family HT135_02915 ENOG4105CGD Nad-dependent epimerase dehydratase HT135_02930 ENOG4105DM4 PTS System HT135_02935 ENOG4105DG6 mannose-6-phosphate isomerase HT135_02940 ENOG4108ZMQ domain protein HT135_02945 ENOG4107Y9U Membrane HT135_02955 ENOG4108WC5 Alpha Beta Hydrolase Fold protein HT135_02960 ENOG4105Z7P Acetyltransferase (GNAT) family HT135_02975 ENOG4108TVJ Nitroreductase HT135_02980 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HT135_02985 ENOG4108VGI doxx family HT135_02990 ENOG4105XXY Thioredoxin HT135_02995 ENOG4105PF9 Transcriptional regulator HT135_03005 ENOG4105WQG acetyltransferase HT135_03015 ENOG4105CK5 oxidoreductase HT135_03020 ENOG4105ETE Transcriptional regulator (LacI family HT135_03025 ENOG4105C54 Major Facilitator superfamily HT135_03040 ENOG4105C85 amino acid HT135_03050 ENOG41062A4 Transcriptional regulator HT135_03055 ENOG4105EYF MMPL domain protein HT135_03065 ENOG4108TVJ Nitroreductase HT135_03070 ENOG4105FS7 Transcriptional regulator HT135_03075 ENOG4108JCI Transcriptional regulator HT135_03080 ENOG4108UMN azlc family HT135_03090 ENOG4105C2C drug resistance transporter, Bcr CflA HT135_03100 ENOG4105DRR Transcriptional regulator, GntR family HT135_03105 ENOG4105VRS hydrolase family 18 HT135_03125 ENOG4105G6Z alkaline phosphatase HT135_03130 ENOG4107TVP HD domain protein HT135_03135 ENOG41090UD (LipO)protein HT135_03140 ENOG4105F27 Major Facilitator HT135_03145 ENOG4105VZJ PTS System HT135_03150 ENOG4105VCP PTS System HT135_03155 ENOG4105CK1 PTS System HT135_03160 ENOG4105CS2 ec 3.2.1.21 HT135_03165 ENOG4108TZY GntR Family Transcriptional Regulator HT135_03170 ENOG4105EVU fructokinase HT135_03175 ENOG4105DG6 mannose-6-phosphate isomerase HT135_03180 ENOG4105D3P Mannan endo-1,4-beta-mannosidase HT135_03225 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HT135_03230 ENOG4105K8N protein family UPF0079, ATPase HT135_03235 ENOG41072GX Peptidase M22 Glycoprotease HT135_03240 ENOG410801F ribosomal-protein-alanine acetyltransferase HT135_03245 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HT135_03250 ENOG4105C5H ABC transporter HT135_03255 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HT135_03260 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HT135_03265 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HT135_03270 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HT135_03280 ENOG4108TYN CAAX amino terminal protease family protein HT135_03290 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) HT135_03295 ENOG4105ESF Peptidoglycan binding domain protein HT135_03305 ENOG4105PGZ NB-ARC domain HT135_03310 ENOG4105CPQ Dehydrogenase HT135_03315 ENOG4105CT4 transporter HT135_03325 ENOG41087YS Phage shock protein A HT135_03330 ENOG4105DQX Zinc finger domain HT135_03335 ENOG4108WV1 Pfam:DUF477 HT135_03345 ENOG4108ZMR Ion transport 2 domain-containing protein HT135_03350 ENOG4107QNK )-transporter HT135_03380 ENOG4107YUH hydrolase HT135_03390 ENOG4107STQ Multicopper oxidase HT135_03395 ENOG4105C85 amino acid HT135_03405 ENOG4105C7R Atpase associated with various cellular activities aaa_3 HT135_03435 ENOG4105C7N Xanthine uracil vitamin C permease HT135_03460 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HT135_03465 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HT135_03470 ENOG4105C83 adenylosuccinate lyase HT135_03475 ENOG4105C8V SAICAR synthetase HT135_03480 ENOG4105VR9 phosphoribosylformylglycinamidine synthase HT135_03485 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HT135_03490 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HT135_03500 ENOG4105CXB phosphoribosylaminoimidazole synthetase HT135_03505 ENOG4108V3E phosphoribosylglycinamide formyltransferase HT135_03510 ENOG4105DC1 bifunctional purine biosynthesis protein purh HT135_03515 ENOG4105C12 Phosphoribosylglycinamide synthetase HT135_03525 ENOG4105DVH amino acid HT135_03540 ENOG4108R5T secreted protein HT135_03545 ENOG4105KGF protein, YerC YecD HT135_03550 ENOG4105CBC glutamate synthase HT135_03555 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) HT135_03560 ENOG4105C4R Atp-dependent dna helicase HT135_03565 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HT135_03575 ENOG4105CRN Aminoglycoside phosphotransferase HT135_03580 ENOG4105KT7 mgtC SapB transporter HT135_03585 ENOG4105CK7 Sodium proline symporter HT135_03590 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HT135_03595 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HT135_03600 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HT135_03605 ENOG4108IG5 Transcriptional regulator HT135_03615 ENOG4105CBD Diacylglycerol kinase HT135_03620 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HT135_03695 ENOG4105CDY transcriptional regulatory protein HT135_03710 ENOG4105M4P Tetr family transcriptional regulator HT135_03715 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein HT135_03720 ENOG4107S9F NmrA family HT135_03725 ENOG4105KHM amidohydrolase 2 HT135_03730 ENOG4105ST3 Transcriptional regulator HT135_03745 ENOG4105WEF catalase HT135_03750 ENOG4105M18 -acetyltransferase HT135_03765 ENOG4105C2F Histidine kinase HT135_03770 ENOG4105EQD regulatoR HT135_03775 ENOG410769Z extracellular solute-binding protein family 1 HT135_03780 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HT135_03785 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component HT135_03790 ENOG4105F5H Glycosyl Hydrolase Family 88 HT135_03795 ENOG41075H3 AraC family transcriptional regulator HT135_03800 ENOG4107TDE lipolytic protein G-D-S-L family HT135_03815 ENOG4105CX8 fg-gap repeat protein HT135_03820 ENOG4105CX8 fg-gap repeat protein HT135_03825 ENOG4105CPC Aldo Keto reductase HT135_03830 ENOG4107TDE lipolytic protein G-D-S-L family HT135_03840 ENOG4105EKC HT135_03845 ENOG4105E0S extracellular solute-binding protein family 1 HT135_03855 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HT135_03860 ENOG4105F8D glycoside hydrolase family 4 HT135_03865 ENOG4105H67 Protein of unknown function (DUF421) HT135_03870 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) HT135_03875 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HT135_03895 ENOG4106I4J membrane HT135_03900 ENOG41082F9 transcriptional regulator HT135_03905 ENOG41061H0 Monooxygenase HT135_03910 ENOG4108R1P HT135_03915 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HT135_03920 ENOG4105E0M Sulfatase HT135_03925 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HT135_03935 ENOG41090R9 glycosyltransferase HT135_03940 ENOG4107R51 Glycosyl transferase, family 2 HT135_03945 ENOG41090R9 glycosyltransferase HT135_03950 ENOG4105EU0 Major facilitator Superfamily HT135_03960 ENOG4105CUB amino acid HT135_03965 ENOG4105C26 Dehydrogenase HT135_03970 ENOG4105FKZ Methyl-accepting chemotaxis HT135_03975 ENOG4105C5H ABC transporter HT135_03985 ENOG4107SWG transcriptional regulator MERR family HT135_03990 ENOG4105DXB Major Facilitator superfamily HT135_04000 ENOG4105C5H ABC transporter HT135_04005 ENOG4105FDU atp-dependent rna helicase HT135_04015 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HT135_04020 ENOG4105E0A ABC, transporter HT135_04025 ENOG4108U1V ABC transporter, permease HT135_04030 ENOG4105DQ5 transport system permease protein HT135_04035 ENOG4108HUF Transporter HT135_04050 ENOG4108J20 pectate lyase HT135_04055 ENOG4107QPK )-transporter HT135_04075 ENOG4106WTF Glycosyl transferase, family 2 HT135_04080 ENOG4107RGC Glycosyl transferase, family 2 HT135_04090 ENOG4108MRH transcriptional regulatory protein HT135_04115 ENOG410855V Acylphosphatase HT135_04120 ENOG4108RPX mosc domain containing protein HT135_04140 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) HT135_04165 ENOG4105C5Y PTS System HT135_04170 ENOG4105CG3 alpha amylase, catalytic region HT135_04175 ENOG4107414 GntR family transcriptional regulator HT135_04180 ENOG4108RCM Nitroreductase HT135_04185 ENOG4105CGH 5'-nucleotidase HT135_04190 ENOG4107RKG DJ-1/PfpI family HT135_04205 ENOG4105KJF protein tyrosine phosphatase HT135_04215 ENOG4107U9T Pfam:Ribonuclease_BN HT135_04220 ENOG4108ISG Major Facilitator HT135_04225 ENOG4105UPD Calcium Proton HT135_04235 ENOG4105D8X mechanosensitive ion channel HT135_04260 ENOG4106KE4 Dehydrogenase HT135_04265 ENOG4105D7N magnesium and cobalt transport protein CorA HT135_04275 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HT135_04285 ENOG4105BZ1 (ABC) transporter HT135_04290 ENOG4105CJA serine threonine protein kinase HT135_04310 ENOG4105CFC Transporter HT135_04340 ENOG4107RUY (E1 component), alpha subunit HT135_04350 ENOG4107QKR Dehydrogenase HT135_04360 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HT135_04365 ENOG41069DP small acid-soluble spore protein HT135_04370 ENOG4105KK4 UPF0060 membrane protein HT135_04400 ENOG4105F8D glycoside hydrolase family 4 HT135_04405 ENOG4108Q3X Transcriptional regulator HT135_04410 ENOG4105CI1 PTS System HT135_04415 ENOG4105BZ1 (ABC) transporter HT135_04420 ENOG4105BZ1 (ABC) transporter HT135_04430 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HT135_04435 ENOG4105ID8 Transcriptional regulator, ARAC family HT135_04440 ENOG4107QNK )-transporter HT135_04445 ENOG4107QP6 Xylose isomerase domain protein TIM barrel HT135_04450 ENOG4105CIB oxidoreductase Domain protein HT135_04455 ENOG4105BZU Histidine kinase HT135_04460 ENOG4105WH1 Two component transcriptional regulator luxr family HT135_04465 ENOG4105CJ1 ABC, transporter HT135_04470 ENOG41090VJ ABC-2 type transporter HT135_04475 ENOG4108KYE ABC-2 type transporter HT135_04480 ENOG4105U3E Transcriptional regulator HT135_04485 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold HT135_04490 ENOG4105H93 Acyltransferase family HT135_04495 ENOG4108YYS metal-dependent hydrolase (By similarity) HT135_04500 ENOG4105C0R drug resistance transporter emrb qaca subfamily HT135_04505 ENOG410834F Transcriptional regulator HT135_04515 ENOG4108MES Periplasmic binding protein HT135_04520 ENOG4105DQ5 transport system permease protein HT135_04525 ENOG4108IHU transport system permease protein HT135_04530 ENOG4105JAB phenazine biosynthesis protein, phzf family HT135_04535 ENOG4107Y03 Nitroreductase HT135_04550 ENOG4105ECP epimerase HT135_04565 ENOG4105F27 Major Facilitator HT135_04580 ENOG4105VZ8 Transcriptional regulator HT135_04590 ENOG4106AKJ HT135_04595 ENOG4105D74 hydrolase HT135_04600 ENOG4105CKK Glycosyl transferase, family 2 HT135_04605 ENOG4105EJV Membrane HT135_04610 ENOG41067AE Membrane-bound metal-dependent hydrolase HT135_04615 ENOG4105CEN a g-specific adenine glycosylase HT135_04620 ENOG4106BXE HT135_04625 ENOG4105CAN Short-chain dehydrogenase reductase Sdr HT135_04640 ENOG4105EVI UPF0374 protein HT135_04645 ENOG4105BZ1 (ABC) transporter HT135_04650 ENOG4107NBY Membrane HT135_04660 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HT135_04665 ENOG4105G5W regulator Fur family HT135_04775 ENOG4108N23 SpoOM-related protein HT135_04785 ENOG4105E2A Dehydrogenase HT135_04790 ENOG4105PGS Spore coat protein HT135_04805 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HT135_04820 ENOG4105E2Y ABC, transporter HT135_04825 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein HT135_04830 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HT135_04835 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HT135_04845 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HT135_04850 ENOG4107D63 HT135_04855 ENOG4105VZ8 Transcriptional regulator HT135_04870 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HT135_04880 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HT135_04900 ENOG4105CYN Serine protein kinase HT135_04905 ENOG4106AKX UPF0229 protein HT135_04910 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HT135_04915 ENOG4105CW7 secretion protein, HlyD family HT135_04920 ENOG4105C0R drug resistance transporter emrb qaca subfamily HT135_04925 ENOG4105CS1 NAD(P)H quinone oxidoreductase HT135_04940 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HT135_04945 ENOG4105CZV ABC transporter HT135_04950 ENOG4105CJ1 ABC, transporter HT135_04955 ENOG4108TU7 Inherit from COG: (ABC) transporter HT135_04960 ENOG4105VEQ Cold shock protein HT135_04970 ENOG4105BZU Histidine kinase HT135_05010 ENOG4108YBP pseudouridine synthase HT135_05020 ENOG41080XP Cbs domain HT135_05025 ENOG4107YBY Hydrolase HT135_05030 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HT135_05040 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HT135_05045 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HT135_05055 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HT135_05060 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HT135_05070 ENOG4105BZU Histidine kinase HT135_05075 ENOG4105WH1 Two component transcriptional regulator luxr family HT135_05110 ENOG4105ED1 spovr family HT135_05115 ENOG4105G6Z alkaline phosphatase HT135_05130 ENOG4105BZN citrate synthase HT135_05135 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HT135_05140 ENOG4105CUB amino acid HT135_05145 ENOG4105C8J )-transporter HT135_05150 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HT135_05165 ENOG4105J37 HT135_05170 ENOG4108AEY RNA polymerase sigma factor HT135_05175 ENOG4108FN7 Aldo keto reductase HT135_05180 ENOG4105F6E Acyl-transferase HT135_05185 ENOG4107VFR oxidoreductase HT135_05190 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) HT135_05195 ENOG4105C37 (CBS) domain HT135_05205 ENOG4105CHM Aminotransferase HT135_05210 ENOG4105C37 (CBS) domain HT135_05220 ENOG4105WMR Protein CrcB homolog HT135_05225 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HT135_05235 ENOG4105D64 Mechanosensitive ion channel HT135_05240 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HT135_05245 ENOG4107VMI polysaccharide deacetylase HT135_05250 ENOG4105F0I Aminotransferase HT135_05270 ENOG4105BZ1 (ABC) transporter HT135_05275 ENOG4105BZ1 (ABC) transporter HT135_05300 ENOG410839P HT135_05310 ENOG4106MP8 UPF0754 membrane protein HT135_05315 ENOG4105WZB UPF0342 protein HT135_05320 ENOG4105F1N DNA alkylation repair HT135_05330 ENOG4105D4P Coproporphyrinogen iii oxidase HT135_05335 ENOG4107S91 Sodium hydrogen exchanger HT135_05340 ENOG4105NCW Trka-c domain protein HT135_05350 ENOG4105CGU Enoyl-CoA hydratase HT135_05360 ENOG4108IUX (ABC) transporter HT135_05365 ENOG4105RHA ABC transporter, permease HT135_05370 ENOG4107VRP DNA repair exonuclease HT135_05375 ENOG4106D4I domain protein HT135_05380 ENOG4105EQI Metal Dependent Phosphohydrolase HT135_05390 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HT135_05435 ENOG4105NBU tryptophan transport protein HT135_05440 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HT135_05445 ENOG4105K59 histidine triad (HIT) protein HT135_05480 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation HT135_05485 ENOG4105BZ4 penicillin-binding protein HT135_05490 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HT135_05495 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HT135_05500 ENOG4105C1Q protoporphyrinogen oxidase HT135_05510 ENOG4105ECB domain protein HT135_05520 ENOG41090T1 Membrane HT135_05525 ENOG4105DER m42 family HT135_05540 ENOG4106AXD HT135_05545 ENOG4108RQ5 Beta-lactamase domain-containing protein HT135_05550 ENOG4105DF9 Lipoate-protein, ligase HT135_05560 ENOG4105CEY Amp-dependent synthetase and ligase HT135_05570 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 HT135_05575 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HT135_05580 ENOG4105KD7 acetyltransferase HT135_05590 ENOG4108HUF Transporter HT135_05595 ENOG4107TB6 phosphoglycerate mutase HT135_05605 ENOG4107F3J Amp-dependent synthetase and ligase HT135_05610 ENOG4107ZYJ bioY protein HT135_05615 ENOG4106YBV Methyl-accepting chemotaxis HT135_05635 ENOG4105XVF Competence transcription factor HT135_05645 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HT135_05650 ENOG4105X3H Excalibur domain protein HT135_05655 ENOG4105E1V na solute symporter HT135_05660 ENOG4106CAD Protein of unknown function (DUF3311) HT135_05665 ENOG41060YP HT135_05680 ENOG4107SCK Monooxygenase HT135_05685 ENOG4108INS Transcriptional regulator HT135_05705 ENOG4105TRI Hydrolase HT135_05720 ENOG4108KK1 membrane protein AbrB duplication HT135_05725 ENOG4106K7D Major facilitator family transporter HT135_05730 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HT135_05735 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding HT135_05750 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HT135_05760 ENOG4105EYH Exonuclease HT135_05810 ENOG4105ERH Fumarylacetoacetate hydrolase HT135_05820 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HT135_05830 ENOG4105CAQ asparagine synthetase HT135_05845 ENOG4105UQX Mate efflux family protein HT135_05850 ENOG4106HBX Transcriptional Regulator AraC Family HT135_05855 ENOG4105ETE Transcriptional regulator (LacI family HT135_05860 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HT135_05865 ENOG4105SF0 DinB family HT135_05870 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HT135_05875 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HT135_05880 ENOG4105MYW Pentapeptide repeat protein HT135_05885 ENOG4107S9D Alpha beta hydrolase HT135_05890 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HT135_05895 ENOG4107RIQ Sulfate adenylate transferase HT135_05900 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HT135_05905 ENOG4108N5B 2-phosphosulfolactate phosphatase HT135_05910 ENOG41061P3 phosphosulfolactate synthase HT135_05920 ENOG4105DIA mandelate racemase muconate lactonizing HT135_05925 ENOG4107RCC Major Facilitator Superfamily HT135_05930 ENOG4108SZE gCN5-related N-acetyltransferase HT135_05935 ENOG4105MA6 gCN5-related N-acetyltransferase HT135_05945 ENOG4108VPT UPF0234 protein HT135_05950 ENOG4105QNR S1 RNA binding domain protein HT135_05970 ENOG4105K7K Transcriptional regulator HT135_05980 ENOG410751J HT135_05985 ENOG4105D4Y metalloprotease HT135_05990 ENOG4105EPR degv family HT135_05995 ENOG4107AYK membrAne HT135_06005 ENOG41073B9 HT135_06015 ENOG4108KP7 hydrolase HT135_06020 ENOG4108MXZ Esterase HT135_06025 ENOG4105VG1 fes assembly suf system protein HT135_06035 ENOG4105IQ5 FAD linked oxidase domain protein HT135_06045 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HT135_06050 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HT135_06060 ENOG4105C8Y Acetylornithine aminotransferase HT135_06065 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HT135_06075 ENOG4105DBV ornithine carbamoyltransferase HT135_06100 ENOG4107RMD Basic membrane lipoprotein HT135_06115 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HT135_06120 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HT135_06130 ENOG4105C3U ABC transporter HT135_06135 ENOG4108JQ7 (ABC) transporter HT135_06150 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT135_06160 ENOG4105C31 Tryptophanyl-tRNA synthetase HT135_06165 ENOG4108J59 Extracellular solute-binding protein, family 5 HT135_06170 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HT135_06175 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT135_06185 ENOG4108JQ7 (ABC) transporter HT135_06200 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) HT135_06205 ENOG4108ZCF integral membrane protein HT135_06215 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis HT135_06225 ENOG4105DPN Oligoendopeptidase f HT135_06235 ENOG4105T58 Dithiol-disulfide isomerase HT135_06240 ENOG4108Z18 K06886 hemoglobin HT135_06245 ENOG4105E4C Lytic transglycosylase catalytic HT135_06250 ENOG4105MIX Adenylate cyclase HT135_06265 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HT135_06270 ENOG4105EMS pseudouridine synthase HT135_06285 ENOG4105ETU transcriptional activator (TenA HT135_06290 ENOG4108VEU Thiamine monophosphate synthase HT135_06305 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HT135_06310 ENOG4105D06 uba thif-type nad fad binding protein HT135_06315 ENOG4105DWF phosphomethylpyrimidine kinase HT135_06320 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HT135_06325 ENOG4107A88 HT135_06375 ENOG4105ENA helicase HT135_06390 ENOG4108ZMI UPF0477 protein HT135_06400 ENOG4105C28 cystathionine HT135_06405 ENOG4105C28 cystathionine HT135_06410 ENOG4105D9U N-acetyltransferase HT135_06415 ENOG4105JHY Membrane HT135_06425 ENOG4105VTR Integrase HT135_06440 ENOG4108ZUE Phage regulatory protein rha HT135_06445 ENOG4107D0N HT135_06560 ENOG4108FKH Transglycosylase SLT domain HT135_06575 ENOG410651K Teichoic acid biosynthesis protein C HT135_06580 ENOG41068G1 HT135_06600 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HT135_06660 ENOG4106BHF HT135_06705 ENOG41083Q9 chitosanase HT135_06720 ENOG4105G7B Protein of unknown function (DUF2992) HT135_06725 ENOG4105VMI -acetyltransferase HT135_06730 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family HT135_06745 ENOG4107TXC Transcriptional regulator HT135_06765 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HT135_06775 ENOG4108ZJ4 polysaccharide deacetylase HT135_06780 ENOG4107CUJ Protein of unknown function (DUF2690) HT135_06805 ENOG4108IEG Formate dehydrogenase Alpha subunit HT135_06830 ENOG4106A3M Cytochrome p-450 HT135_06835 ENOG41087PP glycosyltransferase MGT family HT135_06850 ENOG4105EXQ uroporphyrinogen iii synthase hem4 HT135_06855 ENOG4105C4B ABC transporter, permease HT135_06860 ENOG4108IXI (ABC) transporter HT135_06870 ENOG4105Q95 Cupin 2, conserved barrel domain protein HT135_06885 ENOG4105D2H Uronic isomerase HT135_06890 ENOG4105CT4 transporter HT135_06895 ENOG4105DG4 malate L-lactate dehydrogenase HT135_06900 ENOG4105CPQ Dehydrogenase HT135_06905 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HT135_06910 ENOG4105DMW Dehydrogenase reductase HT135_06915 ENOG4108I5G Major Facilitator superfamily HT135_06920 ENOG4107KJX Transcriptional regulator HT135_06925 ENOG4107QZW Altronate oxidoreductase HT135_06930 ENOG4105CTX dehydratase HT135_06935 ENOG4107TSN permease HT135_06955 ENOG41068K0 YCII-related domain HT135_06960 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HT135_06970 ENOG4105K7W phage-related replication protein HT135_06975 ENOG4105WEF catalase HT135_06980 ENOG410635T phage-like element pbsx protein HT135_07025 ENOG4108TFU terminase (Small subunit) HT135_07030 ENOG4105IG6 Phage terminase, large subunit HT135_07035 ENOG4108MDF Phage Portal Protein HT135_07060 ENOG41060SN HT135_07075 ENOG4105PQS phage protein HT135_07080 ENOG4105FR7 XkdM protein, phage-like element PBSX HT135_07085 ENOG4105MTC XkdN-like protein HT135_07095 ENOG4108FKH Transglycosylase SLT domain HT135_07100 ENOG4108WZM domain protein HT135_07105 ENOG4105X7F HT135_07115 ENOG4105MFU Protein of unknown function (DUF2634) HT135_07120 ENOG41066EA baseplate J family protein HT135_07125 ENOG410906S phage-like element pbsx protein xkdt HT135_07135 ENOG41068G1 HT135_07165 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HT135_07185 ENOG4105CJ3 phosphate transporter HT135_07190 ENOG4107GRR phosphate transport regulator HT135_07195 ENOG4107R7I amino acid HT135_07205 ENOG4105EDW glycosyl transferase, family 39 HT135_07210 ENOG4105CKK Glycosyl transferase, family 2 HT135_07220 ENOG4105C0H protease HT135_07230 ENOG4108ME1 Peptidase M55 D-aminopeptidase HT135_07235 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HT135_07240 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT135_07245 ENOG4105C3U ABC transporter HT135_07255 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HT135_07260 ENOG4105DTQ mandelate racemase muconate lactonizing HT135_07265 ENOG4107SN7 NLP P60 protein HT135_07270 ENOG4108JQ7 (ABC) transporter HT135_07275 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HT135_07280 ENOG4107TUM Amidinotransferase HT135_07285 ENOG4108S4H thioesterase Superfamily protein HT135_07290 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HT135_07310 ENOG4108428 Inherit from COG: -acetyltransferase HT135_07320 ENOG41080TC multidrug resistance protein HT135_07325 ENOG4105CIY formyltetrahydrofolate deformylase HT135_07330 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HT135_07345 ENOG4105K56 Transcriptional regulator HT135_07350 ENOG4108ZHJ Organic hydroperoxide resistance protein HT135_07355 ENOG4107TVC Glycosyl transferase, family 2 HT135_07360 ENOG4107Y2X deaminase HT135_07365 ENOG4105CVJ phosphoglycerate mutase HT135_07370 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HT135_07375 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HT135_07385 ENOG4108W7F transporter, permease HT135_07390 ENOG4108JJB ABC transporter HT135_07395 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein HT135_07400 ENOG4108X43 YKOF domain protein HT135_07405 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HT135_07410 ENOG41062D9 Histidine kinase HT135_07420 ENOG4106849 propeptide, pepSY amd peptidase M4 HT135_07430 ENOG4105CJW magnesium transporter HT135_07435 ENOG4105V75 Transcriptional regulator HT135_07480 ENOG4105DQE DNA ligase HT135_07485 ENOG4105FDF Could be involved in DNA repair (By similarity) HT135_07490 ENOG4105BZU Histidine kinase HT135_07495 ENOG4107T5V SNARE associated Golgi HT135_07500 ENOG4107TS3 membrane protein, TerC HT135_07505 ENOG4108WZW RNA polymerase sigma HT135_07515 ENOG410681C small acid-soluble spore protein HT135_07525 ENOG4105D0M Protease HtpX homolog HT135_07545 ENOG4108TGC Acyltransferase HT135_07550 ENOG4105BZU Histidine kinase HT135_07555 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HT135_07565 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HT135_07570 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HT135_07575 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HT135_07585 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit HT135_07590 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) HT135_07595 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HT135_07600 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) HT135_07620 ENOG4105BZU Histidine kinase HT135_07625 ENOG41090MY MarR family Transcriptional regulator HT135_07630 ENOG4105ER2 Ompa motb domain protein HT135_07635 ENOG4105E14 MotA TolQ exbB proton channel HT135_07645 ENOG4108K88 Membrane HT135_07650 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HT135_07655 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase HT135_07660 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HT135_07665 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HT135_07670 ENOG4105FEA Spore maturation protein HT135_07700 ENOG4105F0V Cell wall hydrolase HT135_07715 ENOG4105C59 p-type ATPase HT135_07725 ENOG4105DC7 peptidase M24 HT135_07735 ENOG4105CID antiterminator HT135_07745 ENOG4105KRI phosphocarrier protein (HPr HT135_07750 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HT135_07760 ENOG4105F6S Spore photoproduct lyase HT135_07770 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HT135_07775 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HT135_07780 ENOG4105K4I Scp-like extracellular HT135_07790 ENOG4105BZU Histidine kinase HT135_07795 ENOG4105CHM Aminotransferase HT135_07805 ENOG4107R88 Chemotaxis protein (CheV) HT135_07810 ENOG4105UIN HT135_07820 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein HT135_07830 ENOG4105K6S Short-chain dehydrogenase reductase Sdr HT135_07835 ENOG4105EPM Diguanylate phosphodiesterase HT135_07840 ENOG4105WEF catalase HT135_07845 ENOG4107IN1 Protein of unknown function (DUF1797) HT135_07850 ENOG4108XRC Protein of unknown function (DUF458) HT135_07880 ENOG4105NQC Flavodoxin HT135_07890 ENOG4105CH2 amidohydrolase HT135_07900 ENOG4105D8X mechanosensitive ion channel HT135_07905 ENOG4105D3R alkyl hydroperoxide reductase HT135_07910 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HT135_07925 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HT135_07930 ENOG4105D06 uba thif-type nad fad binding protein HT135_07935 ENOG4105CVM Molybdenum cofactor synthesis domain protein HT135_07940 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein HT135_07945 ENOG4108ZAF Molybdopterin HT135_07950 ENOG41067WU Molybdopterin converting factor (Subunit 1) HT135_07955 ENOG4105BZ1 (ABC) transporter HT135_07960 ENOG4105BZ1 (ABC) transporter HT135_07970 ENOG4107X8C Efflux transporter RND family MFP subunit HT135_07975 ENOG4105C19 ABC transporter HT135_07980 ENOG4107RBB ABC transporter, permease HT135_07985 ENOG4105E98 transcriptional regulator DeoR family HT135_07990 ENOG4105DE4 1-phosphofructokinase HT135_07995 ENOG4105DM4 PTS System HT135_08000 ENOG4105C3F Signal peptidase i HT135_08010 ENOG4105C5H ABC transporter HT135_08015 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HT135_08040 ENOG4105BZU Histidine kinase HT135_08050 ENOG4107ZYR domain protein HT135_08060 ENOG4105CN5 Metallo-Beta-Lactamase HT135_08070 ENOG4108X4Q Hydrolase HT135_08075 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HT135_08095 ENOG4105CPP Dehydrogenase, E1 component HT135_08100 ENOG4105C7S Dehydrogenase HT135_08105 ENOG4107QN2 dihydrolipoyl dehydrogenase HT135_08120 ENOG4105CXN decarboxylase HT135_08125 ENOG4105WBI UPF0223 protein HT135_08140 ENOG4105ECY inositol monophosphatase HT135_08150 ENOG4105JQZ Methyltransferase HT135_08190 ENOG4105CI3 gtp-binding protein typa HT135_08195 ENOG4105QA2 HT135_08210 ENOG4108IAB Phoh family HT135_08220 ENOG4105CSV Glutaminase HT135_08225 ENOG4105ZPI UPF0358 protein HT135_08230 ENOG4105CNI cell division protein FtsW HT135_08235 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HT135_08245 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HT135_08255 ENOG4105BZ9 Cytochrome C oxidase, subunit I HT135_08260 ENOG4105CCU oxidase (Subunit III) HT135_08265 ENOG41064X9 cytochrome C oxidase subunit IV HT135_08280 ENOG41080XQ Signal transduction protein with cbs domains HT135_08285 ENOG4106UY4 Inherit from COG: Scp-like extracellular HT135_08305 ENOG4105WUC UPF0298 protein HT135_08310 ENOG4106H78 methyltransferase HT135_08315 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HT135_08320 ENOG4105H20 Sporulation integral membrane protein YlbJ HT135_08325 ENOG4105D78 K07001 NTE family protein HT135_08330 ENOG41063PX domain protein HT135_08340 ENOG4105CDE UPF0348 protein HT135_08345 ENOG4105KNH Nucleic acid-binding protein HT135_08375 ENOG4108V6E Cell division protein mraZ HT135_08380 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HT135_08390 ENOG4105CJN penicillin-binding protein HT135_08395 ENOG4105CJN penicillin-binding protein HT135_08400 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HT135_08405 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HT135_08410 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HT135_08415 ENOG4105CNI cell division protein FtsW HT135_08420 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HT135_08425 ENOG4105D4A Cell wall formation (By similarity) HT135_08430 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) HT135_08435 ENOG4108R2U division initiation protein HT135_08445 ENOG4105K67 small basic protein HT135_08450 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HT135_08455 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HT135_08465 ENOG4105FFI sigma-e processing peptidase spoiiga HT135_08470 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HT135_08480 ENOG4105DKW ABC transporter HT135_08490 ENOG4105WR5 sporulation protein, YlmC YmxH family HT135_08495 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HT135_08500 ENOG4105DFA alanine racemase domain protein HT135_08505 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HT135_08510 ENOG41067XK integral membrane protein HT135_08515 ENOG4105DBK s4 domain protein HT135_08525 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HT135_08535 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HT135_08540 ENOG4105C34 Pseudouridine synthase HT135_08545 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HT135_08555 ENOG4105CXT aspartate transcarbamylase HT135_08565 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HT135_08570 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HT135_08575 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) HT135_08580 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) HT135_08585 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HT135_08590 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HT135_08595 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HT135_08605 ENOG4107S4M Sulfate adenylate transferase HT135_08610 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HT135_08615 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HT135_08620 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HT135_08625 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HT135_08640 ENOG4105DSJ YicC domain protein HT135_08645 ENOG4105KC4 UPF0296 protein HT135_08650 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HT135_08660 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HT135_08665 ENOG4105C25 Primosomal protein n' HT135_08670 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HT135_08675 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HT135_08680 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HT135_08685 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HT135_08690 ENOG4108ZF3 Phosphatase HT135_08695 ENOG4105D9P serine threonine protein kinase HT135_08700 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HT135_08705 ENOG4105DJV ribulose-phosphate 3-epimerase HT135_08710 ENOG4105FJ0 thiamine HT135_08720 ENOG4105VB9 50S ribosomal protein l28 HT135_08725 ENOG4108ZAA Alkaline-shock protein HT135_08730 ENOG4105DP4 dak2 domain fusion protein ylov HT135_08740 ENOG4105EJQ L-serine dehydratase HT135_08745 ENOG4105CB5 ATP-dependent DNA helicase recG HT135_08750 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) HT135_08760 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HT135_08765 ENOG4105CHR reductase HT135_08775 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HT135_08780 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HT135_08785 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HT135_08795 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) HT135_08805 ENOG4105K5M 30s ribosomal protein S16 HT135_08810 ENOG4108BW8 UPF0109 protein HT135_08820 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HT135_08825 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HT135_08830 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HT135_08835 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HT135_08840 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HT135_08850 ENOG4105VM1 flagellar HT135_08855 ENOG4105CMV Succinyl-CoA synthetase subunit beta HT135_08860 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HT135_08865 ENOG4105C79 DNA protecting protein DprA HT135_08870 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HT135_08875 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) HT135_08880 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HT135_08885 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HT135_08890 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HT135_08900 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HT135_08905 ENOG4108ZC9 flagellar basal-body rod protein flgc HT135_08910 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HT135_08915 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HT135_08920 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HT135_08935 ENOG4106YF4 Flagellar biosynthesis chaperone HT135_08945 ENOG410696Y Flagellar hook-length control protein HT135_08950 ENOG410822I Flagellar hook capping protein HT135_08955 ENOG4108JQA flagellar HT135_08960 ENOG41068WV flagellar FlbD family protein HT135_08970 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HT135_08975 ENOG4105DD5 Flagellar motor switch protein HT135_08980 ENOG4107YTP response regulator receiver protein HT135_08990 ENOG4105CN7 Flagellar biosynthetic protein FliP HT135_08995 ENOG4105VS8 Flagellar biosynthetic protein fliq HT135_09000 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HT135_09005 ENOG4105D00 flagellar biosynthetic protein flhB HT135_09010 ENOG4105D7B Flagellar biosynthesis protein flha HT135_09015 ENOG4105FZW flagellar biosynthesis regulator FlhF HT135_09025 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HT135_09030 ENOG4105CBS Chea signal transduction histidine kinase HT135_09035 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis HT135_09050 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HT135_09060 ENOG4105CE9 30S ribosomal protein S2 HT135_09065 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) HT135_09075 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HT135_09080 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HT135_09085 ENOG4105KNE Phosphatidate cytidylyltransferase HT135_09095 ENOG4105DZP Membrane-associated zinc metalloprotease HT135_09100 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HT135_09105 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) HT135_09110 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HT135_09115 ENOG4105CHV Transcription elongation factor NusA HT135_09120 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination HT135_09125 ENOG4105VHM ribosomal protein HT135_09130 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HT135_09135 ENOG4105W7A Protein of unknown function (DUF503) HT135_09140 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HT135_09145 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HT135_09150 ENOG4105DTN riboflavin biosynthesis protein ribF HT135_09155 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HT135_09160 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HT135_09170 ENOG4105C1V Peptidase, M16 HT135_09180 ENOG4105E35 Dipicolinate synthase subunit A HT135_09185 ENOG4108S0H Dipicolinic acid synthetase, b subunit HT135_09190 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HT135_09200 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HT135_09210 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit HT135_09220 ENOG4105CNU cell division protein FtsK HT135_09225 ENOG4105FDP GntR family transcriptional regulator HT135_09245 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HT135_09250 ENOG4105XZV Protein of unknown function (DUF3243) HT135_09265 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HT135_09270 ENOG4105CEV competence damage-inducible protein HT135_09280 ENOG4108A04 Beta-lactamase HT135_09285 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) HT135_09290 ENOG4105D48 metallophosphoesterase HT135_09295 ENOG4105MCT stage V sporulation protein S HT135_09305 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HT135_09310 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HT135_09325 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HT135_09330 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HT135_09365 ENOG4105K7W phage-related replication protein HT135_09395 ENOG4105IIP Membrane HT135_09400 ENOG4105W1N transcriptional regulator HT135_09405 ENOG4108151 Beta-lactamase domain protein HT135_09410 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HT135_09420 ENOG4107QKG PfaD family HT135_09425 ENOG41062T2 Acyl carrier protein HT135_09430 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase HT135_09435 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase HT135_09440 ENOG4108MGH Enoyl-CoA hydratase HT135_09445 ENOG4108KQ6 Enoyl-CoA hydratase HT135_09450 ENOG4105C0W non-ribosomal peptide synthetase HT135_09455 ENOG4107SQU synthase HT135_09465 ENOG4105C0W non-ribosomal peptide synthetase HT135_09475 ENOG4106A3M Cytochrome p-450 HT135_09485 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HT135_09490 ENOG4105K7W phage-related replication protein HT135_09495 ENOG4108X3M OsmC Ohr family protein HT135_09520 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) HT135_09525 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HT135_09545 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HT135_09550 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HT135_09555 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HT135_09560 ENOG4105U6W MutT NUDIX family protein HT135_09565 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HT135_09570 ENOG4106F1P AAA ATPase, central domain protein HT135_09575 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HT135_09580 ENOG4105CXI aluminum resistance protein HT135_09585 ENOG4105KV4 Transcriptional regulator HT135_09590 ENOG4105C5F glutamine synthetase HT135_09595 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HT135_09605 ENOG4106BHF HT135_09610 ENOG410780I phosphoprotein phosphatase activity HT135_09620 ENOG4108U7W acetyltransferase HT135_09655 ENOG4108RZ2 Glycoside hydrolase family 16 HT135_09695 ENOG4107T94 Endo-14-beta-xylanase HT135_09720 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HT135_09725 ENOG41073R8 VanW family HT135_09730 ENOG4105NX3 Membrane HT135_09735 ENOG4105VMP Transcriptional regulator HT135_09745 ENOG4108RAV Conserved protein HT135_09790 ENOG4105FVX HT135_09800 ENOG4105K7W phage-related replication protein HT135_09820 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) HT135_09830 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HT135_09840 ENOG4108SVB resolvase HT135_09845 ENOG4105VPS UPF0291 protein HT135_09850 ENOG4105CV1 Transketolase (EC 2.2.1.1) HT135_09870 ENOG4107QIV Cytochrome c biogenesis protein HT135_09895 ENOG4107DZX Small, acid-soluble spore protein P HT135_09905 ENOG4108I0Z Aconitate hydratase HT135_09910 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HT135_09925 ENOG41067CD Small, acid-soluble spore protein Tlp HT135_09935 ENOG4105MI2 HT135_09940 ENOG4105W8X HesB YadR YfhF-family protein HT135_09945 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HT135_09950 ENOG4105K4P CoA-binding domain protein HT135_09955 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HT135_09975 ENOG4107QWR cellulase (EC 3.2.1.4) HT135_09990 ENOG4108MYR Secreted protein HT135_09995 ENOG4107SYN Glycosyl hydrolases family 43 HT135_10010 ENOG4107T5V SNARE associated Golgi HT135_10020 ENOG4107QX3 carboxylase HT135_10025 ENOG4105E39 Enoyl-CoA hydratase HT135_10030 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HT135_10035 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HT135_10040 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HT135_10045 ENOG4105CEY Amp-dependent synthetase and ligase HT135_10050 ENOG4105C1G acyl-Coa dehydrogenase HT135_10060 ENOG4105F32 YngK protein HT135_10065 ENOG4106U2H Protein of unknown function (DUF1360) HT135_10075 ENOG4105CEY Amp-dependent synthetase and ligase HT135_10080 ENOG4105C0W non-ribosomal peptide synthetase HT135_10090 ENOG4105C0W non-ribosomal peptide synthetase HT135_10095 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family HT135_10100 ENOG4108N2V aldose 1-epimerase HT135_10105 ENOG4107QJQ Mate efflux family protein HT135_10130 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HT135_10135 ENOG4105SKE transcriptional Regulator LysR family HT135_10140 ENOG4105CB2 alcohol dehydrogenase HT135_10145 ENOG4105BZ8 glutamate synthase HT135_10150 ENOG4105CBC glutamate synthase HT135_10155 ENOG4105C5Q Transcriptional regulator HT135_10160 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HT135_10190 ENOG4108UB7 HT135_10195 ENOG41068WN HT135_10210 ENOG4105CJ1 ABC, transporter HT135_10220 ENOG4105IE8 Alpha-ketoglutarate permease HT135_10225 ENOG4107U6E carbohydrate kinase FGGY HT135_10230 ENOG4108M3J Dehydrogenase HT135_10235 ENOG4108J2R molybdopterin oxidoreductase HT135_10245 ENOG4105CIB oxidoreductase Domain protein HT135_10250 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HT135_10255 ENOG4105ETE Transcriptional regulator (LacI family HT135_10260 ENOG4108YQE rare lipoprotein a HT135_10265 ENOG4105XPP Protein of unknown function (DUF1275) HT135_10270 ENOG4108NR7 pectate lyase HT135_10275 ENOG4105CHR reductase HT135_10310 ENOG4105C54 Major Facilitator superfamily HT135_10315 ENOG4107Y9E nuclease HT135_10330 ENOG4105CMG Carbohydrate kinase HT135_10345 ENOG4105DSG hydrolase family 43 HT135_10350 ENOG4105CT4 transporter HT135_10365 ENOG4108M1A Chitin-binding protein HT135_10470 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HT135_10490 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr HT135_10505 ENOG4108Z7R Chaperone CsaA HT135_10510 ENOG4105FTV AraC Family Transcriptional Regulator HT135_10515 ENOG4108HJF gCN5-related N-acetyltransferase HT135_10525 ENOG4108W8B Beta-lactamase domain protein HT135_10535 ENOG4105D29 Helix-turn-helix type 11 domain protein HT135_10545 ENOG4105KTU Transcriptional regulator, arsr family HT135_10555 ENOG4108SJC Membrane HT135_10575 ENOG4105ECK Fatty Acid Desaturase HT135_10580 ENOG4108ZGX Histidine kinase HT135_10585 ENOG4108S01 response regulator HT135_10595 ENOG41069ER domain protein HT135_10600 ENOG4105C9U ATP-dependent DNA helicase RecQ HT135_10610 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HT135_10615 ENOG4105SCY DNAK suppressor HT135_10630 ENOG4105C26 Dehydrogenase HT135_10635 ENOG4105EWU Squalene--hopene cyclase HT135_10640 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HT135_10645 ENOG4105C8J )-transporter HT135_10650 ENOG4105C09 Bile acid HT135_10655 ENOG4105C7S Dehydrogenase HT135_10665 ENOG4107T89 von Willebrand factor, type A HT135_10670 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HT135_10680 ENOG4105K4H Nlp p60 protein HT135_10685 ENOG41087PP glycosyltransferase MGT family HT135_10695 ENOG4107QMU Mate efflux family protein HT135_10700 ENOG4106SCS STAS domain HT135_10720 ENOG4105FR1 rard protein HT135_10740 ENOG41090U3 tautomerase HT135_10760 ENOG4105FBA Phospholipase Carboxylesterase HT135_10775 ENOG4105E1V na solute symporter HT135_10795 ENOG4108VXD carboxy-peptidase HT135_10800 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HT135_10810 ENOG4106Z5R HT135_10815 ENOG410841Q phosphoesterase PA-phosphatase related protein HT135_10845 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HT135_10850 ENOG4108TSC N-acetyltransferase HT135_10855 ENOG4107S4Y M20 DapE family protein YgeY HT135_10870 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HT135_10905 ENOG4107T32 3-phytase (EC 3.1.3.8) HT135_10920 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) HT135_11005 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HT135_11010 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HT135_11035 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HT135_11045 ENOG4106ITI Glutaredoxin HT135_11050 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HT135_11055 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HT135_11065 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HT135_11070 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HT135_11165 ENOG4105DVF Cytosine-specific methyltransferase HT135_11210 ENOG4106J9J DNA polymerase HT135_11220 ENOG4106IVX HT135_11225 ENOG4106PTB DnaB-like helicase C terminal domain HT135_11235 ENOG41088HM HT135_11240 ENOG4106YR8 HT135_11265 ENOG4105K7W phage-related replication protein HT135_11285 ENOG4108RAV Conserved protein HT135_11290 ENOG4108J9Q DNA ligase HT135_11405 ENOG4107D0N HT135_11460 ENOG4107NTZ HT135_11505 ENOG4108NE4 HT135_11535 ENOG41067QW Transcriptional regulator HT135_11545 ENOG4105ZUG HT135_11550 ENOG4105K70 DNA-binding protein HT135_11660 ENOG41068G1 HT135_11700 ENOG4105E4C Lytic transglycosylase catalytic HT135_11725 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HT135_11745 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HT135_11765 ENOG4106ANW SMI1_KNR4 HT135_11770 ENOG4106BHF HT135_11785 ENOG4107Y9E nuclease HT135_11810 ENOG4105C5E polysaccharide biosynthesis protein HT135_11815 ENOG4105E0X reductase HT135_11820 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HT135_11840 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) HT135_11845 ENOG41090WU lipolytic protein G-D-S-L family HT135_11850 ENOG4108KF3 Electron transport protein SCO1 SenC HT135_11860 ENOG4105C7B Threonine dehydratase HT135_11870 ENOG4108UT2 hemolysin iii HT135_11880 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HT135_11900 ENOG4107YX5 Pfam:DUF548 HT135_11905 ENOG4108Y6J UPF0403 protein HT135_11910 ENOG4105C01 Dihydroxy-acid dehydratase HT135_11925 ENOG4108V06 Glutathione peroxidase HT135_11930 ENOG4105CVG Homoserine O-transsuccinylase HT135_11970 ENOG41081VK Ribonuclease HT135_11995 ENOG410890F Dynamin family HT135_12010 ENOG41065KQ synthase HT135_12015 ENOG4105C2W permease HT135_12020 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) HT135_12025 ENOG4105CTD carboxy-peptidase HT135_12030 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HT135_12035 ENOG4108UHU Aldolase HT135_12040 ENOG4105D7K pfkb domain protein HT135_12045 ENOG4108M60 Transcriptional regulator HT135_12055 ENOG4105CHR reductase HT135_12060 ENOG4105DVT helicase HT135_12075 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) HT135_12085 ENOG4105XWG Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity) HT135_12090 ENOG4108UKS UPF0398 protein HT135_12105 ENOG4107X2U Inherit from COG: Exonuclease-like protein HT135_12110 ENOG4108I5C dEAD DEAH box helicase HT135_12160 ENOG4105BZ4 penicillin-binding protein HT135_12170 ENOG4105CSM endonuclease III HT135_12180 ENOG4105C5S asparaginyl-tRNA synthetase HT135_12185 ENOG4105CHM Aminotransferase HT135_12195 ENOG4105YAC HT135_12200 ENOG4105DVT helicase HT135_12205 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HT135_12210 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HT135_12215 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HT135_12220 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HT135_12225 ENOG4105DJ0 Poly(A) Polymerase HT135_12230 ENOG4105CPK Glycosyl transferase (Group 1 HT135_12235 ENOG4105FJR Lmbe family HT135_12240 ENOG4108Z5K methylglyoxal synthase HT135_12245 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HT135_12250 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase HT135_12255 ENOG4108JYZ YitT family HT135_12275 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HT135_12295 ENOG41068YB TPR repeat-containing protein HT135_12300 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HT135_12310 ENOG4105CIH Imidazole acetol-phosphate transaminase HT135_12320 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HT135_12325 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HT135_12335 ENOG4108I0Q anthranilate phosphoribosyltransferase HT135_12340 ENOG4105CRQ synthase (Component I) HT135_12345 ENOG4105KHN chorismate mutase HT135_12350 ENOG4105D49 3-dehydroquinate synthase HT135_12355 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HT135_12360 ENOG4105BZU Histidine kinase HT135_12365 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HT135_12370 ENOG4105EAH synthase HT135_12375 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HT135_12380 ENOG4105XXQ heptaprenyl diphosphate synthase component I HT135_12390 ENOG4105EUJ GTP cyclohydrolase i HT135_12395 ENOG4105K70 DNA-binding protein HT135_12400 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) HT135_12415 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HT135_12420 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HT135_12425 ENOG41065D1 HT135_12430 ENOG4105S2F HT135_12445 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HT135_12450 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HT135_12455 ENOG4105CAT Cytidine monophosphate kinase HT135_12470 ENOG4105MSI germination protein ypeb HT135_12480 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) HT135_12485 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase HT135_12500 ENOG4107RGJ metallophosphoesterase HT135_12515 ENOG4105I7S Abortive infection protein HT135_12520 ENOG4105C9U ATP-dependent DNA helicase RecQ HT135_12525 ENOG4105T7X HT135_12535 ENOG4108SAX Membrane HT135_12540 ENOG4108JQ1 Dehydrogenase HT135_12545 ENOG4105FF2 Type I DHQase HT135_12560 ENOG4105BZU Histidine kinase HT135_12565 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HT135_12570 ENOG4105CRE cytochrome C HT135_12575 ENOG4107TWT Cytochrome c biogenesis protein HT135_12585 ENOG4105FE9 pseudouridine synthase HT135_12595 ENOG4108JIC nucleoside recognition domain protein HT135_12600 ENOG4105DZ1 carboxypeptidase HT135_12610 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HT135_12615 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HT135_12635 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HT135_12640 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HT135_12645 ENOG4108R6K riboflavin synthase, subunit alpha HT135_12650 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HT135_12660 ENOG4105C3F Signal peptidase i HT135_12665 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) HT135_12670 ENOG4107ZE5 PPIases accelerate the folding of proteins HT135_12675 ENOG4105PTM secreted protein HT135_12680 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) HT135_12690 ENOG4105G6R Stage v sporulation protein ae HT135_12700 ENOG4105CZ3 stage V sporulation protein ad HT135_12705 ENOG41090VF Stage v sporulation protein ac HT135_12720 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HT135_12725 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HT135_12730 ENOG41082AN stage II sporulation protein HT135_12735 ENOG4105DZ1 carboxypeptidase HT135_12740 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HT135_12745 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HT135_12750 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HT135_12760 ENOG4105I3K Ferric uptake regulator, Fur family HT135_12765 ENOG4105MZ9 stage II sporulation protein m HT135_12780 ENOG4105DFD Na H antiporter HT135_12785 ENOG4108IJ0 Aspartate ammonia-lyase HT135_12790 ENOG4105HDK L-asparaginase HT135_12795 ENOG4108IMY Transcriptional regulator HT135_12805 ENOG4108YZ4 nudix hydrolase HT135_12815 ENOG4105CPC Aldo Keto reductase HT135_12835 ENOG4106HZJ HT135_12840 ENOG4105RHY Pfam:UPF0157 HT135_12845 ENOG4105KAC Antibiotic biosynthesis monooxygenase HT135_12850 ENOG4108XET gCN5-related N-acetyltransferase HT135_12860 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HT135_12870 ENOG4105E5W Transporter HT135_12880 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase HT135_12895 ENOG4108IXY short-chain dehydrogenase reductase HT135_12900 ENOG41069FQ Metallo-beta-lactamase superfamily HT135_12905 ENOG4105II7 pyrroline-5-carboxylate reductase HT135_12915 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HT135_12925 ENOG410861F 50S ribosomal protein L33 HT135_12930 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HT135_12935 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HT135_12945 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HT135_12950 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HT135_12960 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) HT135_12970 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HT135_12975 ENOG4108HNZ carboxyl transferase HT135_12980 ENOG4108ZVT methylmalonyl-coA epimerase HT135_12990 ENOG4108VZI ErfK ybiS ycfS ynhG family protein HT135_12995 ENOG4108QEG Membrane HT135_13000 ENOG4105CDA abc transporter atp-binding protein HT135_13005 ENOG4105E5Q amino acid AbC transporter HT135_13010 ENOG4108HW3 (ABC) transporter HT135_13015 ENOG4108Y6J UPF0403 protein HT135_13020 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) HT135_13035 ENOG4105C7S Dehydrogenase HT135_13040 ENOG4105CPP Dehydrogenase, E1 component HT135_13055 ENOG4105CKM Branched-chain carboxylic acid kinase HT135_13060 ENOG4107RDP Dehydrogenase HT135_13070 ENOG4108JUB Transcriptional regulator HT135_13075 ENOG4106CCJ Protein of unknown function (DUF2627) HT135_13080 ENOG4105CR4 methylisocitrate lyase HT135_13085 ENOG4105DXD 2-methylcitrate dehydratase HT135_13095 ENOG4105C1G acyl-Coa dehydrogenase HT135_13100 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HT135_13110 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HT135_13115 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HT135_13130 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HT135_13135 ENOG4107QQR Sporulation HT135_13140 ENOG4105S1Z Stage IV sporulation protein B HT135_13145 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HT135_13150 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HT135_13155 ENOG4105DX0 Hemolysin A HT135_13165 ENOG4105CTB Polyprenyl synthetase HT135_13170 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HT135_13175 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HT135_13180 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HT135_13185 ENOG4105M7K Involved in the transcription termination process (By similarity) HT135_13190 ENOG4108ZSR alkaline shock protein HT135_13195 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HT135_13215 ENOG410644B Stage III sporulation protein af HT135_13225 ENOG4105KQ4 Stage iii sporulation protein ad HT135_13230 ENOG4108CQH stage III sporulation protein AC HT135_13235 ENOG4105KR5 Stage iii sporulation protein HT135_13240 ENOG4105CD2 stage iii sporulation protein aa HT135_13250 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HT135_13255 ENOG4105DC7 peptidase M24 HT135_13260 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HT135_13270 ENOG4105CBJ Metal-dependent enzyme HT135_13285 ENOG4105KST dependent repressor HT135_13290 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) HT135_13295 ENOG4105WZW rhodanese family HT135_13300 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HT135_13305 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HT135_13310 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HT135_13315 ENOG4105C0D helicase HT135_13330 ENOG4108IMY Transcriptional regulator HT135_13340 ENOG4105VFR signal peptidase HT135_13395 ENOG41080XP Cbs domain HT135_13405 ENOG4105C37 (CBS) domain HT135_13430 ENOG4105C5X domain protein HT135_13455 ENOG4105E0M Sulfatase HT135_13470 ENOG4107ZXI Rhomboid family HT135_13480 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HT135_13505 ENOG41068DG YceG-like family HT135_13510 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HT135_13515 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HT135_13520 ENOG4105E2Z phosphate ABC transporter (Permease HT135_13525 ENOG4105C8U phosphate abc transporter HT135_13530 ENOG4105CVA phosphate HT135_13535 ENOG4107RF6 penicillin-binding protein HT135_13545 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HT135_13550 ENOG4105SXS Protein of unknown function (DUF456) HT135_13565 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HT135_13570 ENOG41063Y9 HT135_13575 ENOG4108U5J '-nucleotidase HT135_13580 ENOG4105N80 Ferric uptake regulator, Fur family HT135_13585 ENOG4108JYZ YitT family HT135_13590 ENOG41069ZM Protein of unknown function (DUF2624) HT135_13595 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HT135_13610 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HT135_13615 ENOG4105EGD dinuclear metal center protein, YbgI family HT135_13630 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HT135_13635 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HT135_13640 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 HT135_13645 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) HT135_13655 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HT135_13660 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HT135_13665 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HT135_13675 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HT135_13680 ENOG4105KG3 cytidine deaminase HT135_13685 ENOG4107YR5 Diacylglycerol kinase HT135_13690 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HT135_13695 ENOG4105CTJ Metal Dependent Phosphohydrolase HT135_13700 ENOG4105C9A Phoh family HT135_13705 ENOG4105EI1 sporulation protein yqfd HT135_13710 ENOG41068P3 sporulation protein YqfC HT135_13720 ENOG4105DI5 UPF0365 protein HT135_13725 ENOG4105F7J membrane-bound serine protease HT135_13730 ENOG4105KTH gatB Yqey HT135_13745 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HT135_13750 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HT135_13755 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HT135_13765 ENOG4105CFG Acts as a chaperone (By similarity) HT135_13770 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HT135_13775 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HT135_13780 ENOG4105CSA Coproporphyrinogen iii oxidase HT135_13785 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HT135_13795 ENOG4108ZRV stage ii sporulation protein p HT135_13800 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) HT135_13805 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) HT135_13810 ENOG4105TQK DNA polymerase iii, delta' subunit HT135_13825 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HT135_13830 ENOG4108UK2 deaminase HT135_13835 ENOG4105KQC Competence protein HT135_13845 ENOG4108D32 Methyltransferase HT135_13855 ENOG4108WF2 Metal Dependent Phosphohydrolase HT135_13860 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HT135_13865 ENOG410812S Rna-binding protein HT135_13870 ENOG4105E2X shikimate dehydrogenase HT135_13875 ENOG4105CQW ribosome biogenesis GTPase YqeH HT135_13880 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HT135_13895 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HT135_13900 ENOG41080BT SNARE associated Golgi HT135_13915 ENOG4105WFK nuclease HT135_13920 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HT135_13950 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HT135_13965 ENOG4107XZQ multidrug resistance protein HT135_13975 ENOG4105H3G oxidoreductase HT135_13980 ENOG4105PGM cation diffusion facilitator family transporter HT135_14015 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HT135_14080 ENOG4105QBX endodeoxyribonuclease RusA HT135_14100 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) HT135_14120 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HT135_14125 ENOG4105KVH Transcriptional regulator HT135_14130 ENOG4108DBC nitroreductase HT135_14150 ENOG41075D4 Aminoglycoside 6-adenylyltransferase HT135_14160 ENOG41067XF inhibitor HT135_14190 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HT135_14205 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HT135_14210 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HT135_14215 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HT135_14225 ENOG4108JQ7 (ABC) transporter HT135_14235 ENOG4108MEK Metal-binding protein YodA HT135_14245 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein HT135_14250 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein HT135_14265 ENOG4105KRI phosphocarrier protein (HPr HT135_14275 ENOG4105VUF Transcriptional regulator HT135_14280 ENOG4105DQ4 alcohol dehydrogenase HT135_14285 ENOG4108Z0Z intracellular protease Pfpi family HT135_14290 ENOG4108HKT sucrose-6-phosphate hydrolase HT135_14295 ENOG4105F3R pts system mannose fructose sorbose family iid HT135_14300 ENOG4105ETZ PTS System HT135_14305 ENOG4108IQ3 PTS system HT135_14310 ENOG4105YHU PTS system HT135_14315 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HT135_14320 ENOG4105C85 amino acid HT135_14325 ENOG4105N14 lysine exporter protein LysE YggA HT135_14330 ENOG4108NGU Transcriptional regulator HT135_14335 ENOG4105JVQ RNA Polymerase HT135_14340 ENOG4108P49 AntiSigma factor HT135_14345 ENOG4105EXC Acyl-transferase HT135_14350 ENOG4105WDR HT135_14355 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HT135_14360 ENOG41082JN Transcriptional regulator HT135_14380 ENOG4105TMB Formate nitrite transporter HT135_14385 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) HT135_14390 ENOG4108JB9 formate dehydrogenase HT135_14405 ENOG4105C28 cystathionine HT135_14420 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) HT135_14435 ENOG4107XRG penicillin-binding protein HT135_14440 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HT135_14445 ENOG4105DBI uridine monophosphokinase HT135_14450 ENOG4105CFP Peptidase U32 HT135_14455 ENOG4105XYU peptidase (U32 family) HT135_14465 ENOG4105HHA aminodeoxychorismate lyase HT135_14470 ENOG4105VPH UPF0473 protein HT135_14475 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HT135_14480 ENOG4105VBH UPF0297 protein HT135_14485 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HT135_14490 ENOG4105C02 permease HT135_14495 ENOG4105CDA abc transporter atp-binding protein HT135_14500 ENOG4105CT1 (ABC) transporter HT135_14505 ENOG4105EAD ABC transporter HT135_14510 ENOG4105DRP amino acid AbC transporter HT135_14520 ENOG41060CR HT135_14530 ENOG4105C7H Helicase, RecD TraA family HT135_14540 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HT135_14545 ENOG4105C3J Cysteine desulfurase HT135_14555 ENOG4105D1H recombination factor protein RarA HT135_14560 ENOG4105CUZ uba thif-type nad fad binding protein HT135_14570 ENOG4105C9M aspartyl-trna synthetase HT135_14575 ENOG4105CUT histidyl-tRNA synthetase HT135_14585 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HT135_14590 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) HT135_14595 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HT135_14600 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HT135_14605 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HT135_14610 ENOG41067VP Protein of unknown function (DUF1049) HT135_14615 ENOG4105NCW Trka-c domain protein HT135_14620 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HT135_14630 ENOG4105CKP Polysaccharide Biosynthesis Protein HT135_14635 ENOG4108QG2 Membrane HT135_14640 ENOG4105NAP HT135_14645 ENOG4105VIE preprotein translocase, subunit YajC HT135_14650 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HT135_14655 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HT135_14660 ENOG41061AI Protein of unknown function (DUF2905) HT135_14665 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HT135_14670 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HT135_14680 ENOG4105IE8 Alpha-ketoglutarate permease HT135_14685 ENOG4105CK5 oxidoreductase HT135_14705 ENOG4105BZG amino acid carrier protein HT135_14710 ENOG4105CDY transcriptional regulatory protein HT135_14720 ENOG4106678 morphogenetic protein associated with SpoVID HT135_14725 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HT135_14730 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HT135_14735 ENOG4108IYU L-aspartate oxidase HT135_14750 ENOG4105CQC Prephenate dehydratase HT135_14755 ENOG41090I5 UPF0735 ACT domain-containing protein HT135_14760 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HT135_14775 ENOG4105K46 50S ribosomal protein l27 HT135_14780 ENOG4105X36 (ribosomal) protein HT135_14785 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HT135_14800 ENOG4107QMS site-determining protein HT135_14805 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HT135_14810 ENOG4105YHC Rod shape-determining protein MreD HT135_14820 ENOG4105DFF Rod shape-determining protein mreb HT135_14825 ENOG4105W5Q DNA repair protein (RadC HT135_14830 ENOG4108Z03 MAF-like protein HT135_14840 ENOG4106A3R peptidase HT135_14845 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HT135_14850 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HT135_14860 ENOG4106AR7 Spore coat protein HT135_14865 ENOG41068KH stage VI sporulation protein D HT135_14870 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HT135_14875 ENOG4105D52 delta-aminolevulinic acid dehydratase HT135_14885 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HT135_14895 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HT135_14905 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HT135_14910 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HT135_14915 ENOG4108IUQ atp-dependent protease HT135_14920 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HT135_14925 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HT135_14935 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HT135_14940 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HT135_14945 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HT135_14950 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HT135_14955 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HT135_14960 ENOG4108ZP8 Acetolactate synthase small subunit HT135_14965 ENOG4105C7K acetolactate synthase HT135_14975 ENOG4105I4A GCN5-related N-acetyltransferase HT135_14980 ENOG4107KM7 Heat induced stress protein YflT HT135_14990 ENOG4105M59 Phosphodiesterase, mj0936 family HT135_14995 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HT135_15000 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HT135_15005 ENOG4108XJQ germination protein HT135_15010 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HT135_15015 ENOG41067TZ transcriptional regulator, MarR family HT135_15020 ENOG4105PFC Transcriptional regulator HT135_15030 ENOG4105E33 succinate dehydrogenase HT135_15040 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit HT135_15050 ENOG4105CFH Aspartokinase HT135_15060 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HT135_15065 ENOG4105K63 Thioredoxin HT135_15070 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HT135_15075 ENOG4105C10 Electron transfer flavoprotein HT135_15080 ENOG4105BZJ Electron transfer flavoprotein HT135_15085 ENOG41060WC Enoyl-CoA hydratase HT135_15090 ENOG4107Z3H Transcriptional regulator, TetR family HT135_15095 ENOG4105CEY Amp-dependent synthetase and ligase HT135_15105 ENOG4105C98 muts2 protein HT135_15110 ENOG4105DCG PHP domain protein HT135_15125 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HT135_15130 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HT135_15135 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HT135_15145 ENOG4108RWN rrna methyltransferase HT135_15150 ENOG41067MF small acid-soluble spore protein HT135_15160 ENOG4105CQB FAD linked oxidase domain protein HT135_15165 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HT135_15190 ENOG4105K7K Transcriptional regulator HT135_15195 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HT135_15200 ENOG4105DRS transport system, permease HT135_15215 ENOG4108MDK Dehydrogenase HT135_15225 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HT135_15230 ENOG4105EF1 ribulokinase HT135_15240 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase HT135_15245 ENOG4105CN9 Peptidase m42 family protein HT135_15255 ENOG410696E Membrane HT135_15260 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HT135_15265 ENOG4105VJV 50s ribosomal protein L35 HT135_15270 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HT135_15280 ENOG41067MG lrgb family HT135_15290 ENOG4105DY9 regulatoR HT135_15295 ENOG4108HRK Histidine kinase HT135_15305 ENOG4105C22 threonyL-tRNA synthetase HT135_15310 ENOG4108TDW sporulation protein YtxC HT135_15330 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HT135_15335 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HT135_15340 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HT135_15345 ENOG4105KVH Transcriptional regulator HT135_15350 ENOG4105F27 Major Facilitator HT135_15355 ENOG4105CV8 reductase HT135_15360 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HT135_15370 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HT135_15375 ENOG4105C2M dna polymerase I HT135_15380 ENOG4105BZU Histidine kinase HT135_15385 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HT135_15390 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HT135_15395 ENOG4108HMX isocitrate dehydrogenase (NADP) HT135_15400 ENOG4105BZN citrate synthase HT135_15410 ENOG4108REF Sporulation integral membrane protein ytvi HT135_15415 ENOG4105FS0 cytoplasmic membrane protein HT135_15420 ENOG4105CA9 Pyruvate kinase HT135_15425 ENOG4105CTQ phosphohexokinase HT135_15435 ENOG4108IEY Carboxyl transferase domain HT135_15440 ENOG4105C6K Malic enzyme HT135_15445 ENOG4105C0B DNA polymerase III (alpha subunit) HT135_15450 ENOG4105VV2 HT135_15460 ENOG4106EVM HT135_15465 ENOG4105SFS phosphoesterase RecJ domain protein HT135_15480 ENOG410635A Membrane HT135_15485 ENOG4105CH2 amidohydrolase HT135_15505 ENOG4105DEN Luciferase family HT135_15510 ENOG4105CDA abc transporter atp-binding protein HT135_15535 ENOG4108XSB acetyltransferase, (GNAT) family HT135_15540 ENOG4108KSA LysR family transcriptional regulator HT135_15545 ENOG4105E8R UPF0173 metal-dependent hydrolase HT135_15555 ENOG4105CH7 arginosuccinase HT135_15560 ENOG4105CDH Citrulline--aspartate ligase HT135_15565 ENOG4105EPU Molybdenum cofactor synthesis domain protein HT135_15570 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HT135_15580 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HT135_15585 ENOG4105KBJ sporulation protein ytfj HT135_15595 ENOG4105VK3 rdd domain containing protein HT135_15600 ENOG4105D07 Signal peptide peptidase, SppA HT135_15605 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HT135_15610 ENOG4105EFZ amidohydrolase HT135_15615 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HT135_15650 ENOG4105U5Y Transcriptional regulator HT135_15660 ENOG4105BZU Histidine kinase HT135_15665 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HT135_15670 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HT135_15680 ENOG4105F1V Acetoin utilization protein HT135_15685 ENOG4105W87 Cbs domain HT135_15690 ENOG4105DGU Histone deacetylase HT135_15695 ENOG4105ER2 Ompa motb domain protein HT135_15700 ENOG4107R0U MotA TolQ exbB proton channel HT135_15705 ENOG4105ETE Transcriptional regulator (LacI family HT135_15710 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HT135_15730 ENOG4105DFU Cell wall formation (By similarity) HT135_15740 ENOG4108VDD TRNA binding domain protein HT135_15760 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ HT135_15775 ENOG4105C6K Malic enzyme HT135_15780 ENOG4105C8F Beta-lactamase domain protein HT135_15785 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HT135_15795 ENOG4108V15 phosphotransferase enzyme family HT135_15800 ENOG4108IUM Glycogen debranching enzyme HT135_15815 ENOG4107F58 2'-5' rna ligase HT135_15820 ENOG4105C6T cysteine synthase HT135_15825 ENOG4107QSE Dipeptidase HT135_15830 ENOG4105C7N Xanthine uracil vitamin C permease HT135_15845 ENOG4105YW5 deoR family transcriptional regulator HT135_15860 ENOG4105CBX hi0933 family HT135_15865 ENOG4105C94 Transporter HT135_15875 ENOG4105MU9 integral membrane protein HT135_15880 ENOG4105DDC Oxidoreductase domain protein HT135_15890 ENOG4105F5H Glycosyl Hydrolase Family 88 HT135_15900 ENOG41075H3 AraC family transcriptional regulator HT135_15910 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HT135_15920 ENOG4106A3M Cytochrome p-450 HT135_15925 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HT135_15935 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HT135_15940 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HT135_15950 ENOG4105NTD Inherit from COG: Hydrolase HT135_15980 ENOG41085GJ domain protein HT135_15985 ENOG4105C8T Leucyl-tRNA synthetase HT135_15995 ENOG4105BZU Histidine kinase HT135_16000 ENOG410605W Major Facilitator HT135_16005 ENOG4106UBQ HT135_16015 ENOG4105C19 ABC transporter HT135_16020 ENOG4105EWM Histidine kinase HT135_16030 ENOG4107R34 abc transporter permease protein HT135_16035 ENOG4105C19 ABC transporter HT135_16050 ENOG4105DVE abc transporter atp-binding protein HT135_16055 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HT135_16070 ENOG4105N5T Radical SAM Protein HT135_16085 ENOG4105E8V Alpha Beta Hydrolase Fold protein HT135_16090 ENOG4108Z0R Transferase HT135_16095 ENOG4105C85 amino acid HT135_16100 ENOG4105CAQ asparagine synthetase HT135_16105 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HT135_16110 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HT135_16125 ENOG4105D2X ABC transporter substrate-binding protein HT135_16135 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HT135_16150 ENOG4108RMU ferritin dps family protein HT135_16165 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) HT135_16170 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HT135_16175 ENOG4108V2W Carbonate dehydratase HT135_16200 ENOG4105CC5 ABC transporter HT135_16205 ENOG4105CC5 ABC transporter HT135_16210 ENOG4105DIK (ABC) transporter HT135_16215 ENOG4105DSE periplasmic solute binding protein HT135_16220 ENOG4105DTQ mandelate racemase muconate lactonizing HT135_16225 ENOG4105CEY Amp-dependent synthetase and ligase HT135_16230 ENOG4108IPT Naphthoate synthase HT135_16235 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HT135_16240 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HT135_16245 ENOG4105E4F Isochorismate synthase HT135_16265 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HT135_16275 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) HT135_16405 ENOG4105N67 Proton-coupled thiamine transporter YuaJ HT135_16410 ENOG4105VRR gCN5-related N-acetyltransferase HT135_16415 ENOG4105DZ6 Band 7 protein HT135_16425 ENOG4106DF1 HT135_16430 ENOG4108VNY MOSC domain protein HT135_16435 ENOG4108JB8 alcohol dehydrogenase HT135_16445 ENOG4105TRT Transcriptional regulator HT135_16460 ENOG4105CZN Potassium uptake protein HT135_16465 ENOG4107I77 yiaA/B two helix domain HT135_16470 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HT135_16490 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HT135_16500 ENOG4105EE0 oxidoreductase HT135_16505 ENOG4105DKG l-rhamnose isomerase HT135_16510 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) HT135_16515 ENOG4105DET Rhamnulokinase HT135_16520 ENOG4105E98 transcriptional regulator DeoR family HT135_16530 ENOG4105C8Q Methyl-accepting chemotaxis HT135_16535 ENOG4105C8Q Methyl-accepting chemotaxis HT135_16540 ENOG4105C8Q Methyl-accepting chemotaxis HT135_16545 ENOG4105C8Q Methyl-accepting chemotaxis HT135_16560 ENOG4105EA8 2-Nitropropane dioxygenase HT135_16565 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HT135_16575 ENOG4105C37 (CBS) domain HT135_16590 ENOG4107PBV potassium channel HT135_16595 ENOG4107PBV potassium channel HT135_16610 ENOG4107QYV phosphohexose isomerase HT135_16620 ENOG4107QW4 alcohol dehydrogenase HT135_16625 ENOG4105WG9 Conserved Protein HT135_16635 ENOG4105CHM Aminotransferase HT135_16640 ENOG4108ZB6 transcriptional regulator AsnC family HT135_16645 ENOG4108MUZ hydrolase HT135_16655 ENOG4105C87 Aminotransferase class I and II HT135_16660 ENOG4108HGU Histidine kinase HT135_16665 ENOG4105Y38 Kinase-associated protein B HT135_16680 ENOG4105BZ4 penicillin-binding protein HT135_16685 ENOG4105KIR Thiol-disulfide oxidoreductase dcc HT135_16700 ENOG4108MRH transcriptional regulatory protein HT135_16705 ENOG4105DIH basic membrane HT135_16710 ENOG4108JQ9 ABC transporter HT135_16715 ENOG4105UIB (ABC) transporter HT135_16735 ENOG4105D65 subunit l HT135_16740 ENOG4105HC0 Na H antiporter HT135_16745 ENOG4108ZE9 Monovalent cation H antiporter subunit C HT135_16750 ENOG4108JPZ Monovalent cation H antiporter subunit D HT135_16755 ENOG4105SC1 monovalent cation H antiporter subunit E HT135_16765 ENOG4105KJM monovalent cation h antiporter subunit g HT135_16770 ENOG4105KA0 thioesterase Superfamily protein HT135_16805 ENOG4105D58 Diguanylate phosphodiesterase HT135_16810 ENOG4105DAP Nicotinate phosphoribosyltransferase HT135_16835 ENOG4105C02 permease HT135_16850 ENOG410904N short-chain dehydrogenase reductase HT135_16885 ENOG4108K8K Transcriptional regulator HT135_16890 ENOG4105DCF alanine dehydrogenase HT135_16900 ENOG4105WQT MbtH domain protein HT135_16905 ENOG4105CEY Amp-dependent synthetase and ligase HT135_16910 ENOG4105WQI isochorismatase HT135_16915 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HT135_16920 ENOG4105E4F Isochorismate synthase HT135_16925 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HT135_16930 ENOG4105NIV Esterase HT135_16950 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HT135_16960 ENOG41069ER domain protein HT135_16975 ENOG4105CEP NADH dehydrogenase HT135_16980 ENOG4105CAY ferredoxin--nadp reductase HT135_16995 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HT135_17010 ENOG4105ZKE UPF0349 protein HT135_17025 ENOG41083MR nifu domain-containing protein HT135_17030 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein HT135_17035 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HT135_17040 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HT135_17045 ENOG4105D6E homoserine dehydrogenase HT135_17055 ENOG4108W5N phosphatidylglycerophosphatase a HT135_17060 ENOG4105D4U had-superfamily hydrolase, subfamily iia HT135_17070 ENOG4105MMD transcriptional regulator HT135_17075 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) HT135_17080 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HT135_17085 ENOG4105FAA peptidase M23 HT135_17090 ENOG4108YTE sporulation protein YunB HT135_17095 ENOG4105KZD Domain of unknown function (DUF1805) HT135_17100 ENOG4107R8B 5'-nucleotidase HT135_17110 ENOG4105I3N Conserved Protein HT135_17120 ENOG4105CD3 dihydroorotase HT135_17125 ENOG4105G9B Transcriptional regulator HT135_17140 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) HT135_17145 ENOG4105VT2 5-hydroxyisourate hydrolase HT135_17155 ENOG4107YV9 domain protein HT135_17160 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HT135_17175 ENOG4105XRQ Xanthine dehydrogenase accessory factor HT135_17180 ENOG4105C5R Aminotransferase HT135_17190 ENOG4108K8S endonuclease I HT135_17195 ENOG4108IJ9 (ABC) transporter HT135_17200 ENOG4105FDP GntR family transcriptional regulator HT135_17205 ENOG4108KPW sugar kinase HT135_17210 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HT135_17215 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component HT135_17220 ENOG4105XN3 extracellular solute-binding protein family 1 HT135_17225 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HT135_17230 ENOG4105PKS Excinuclease abc c subunit domain protein HT135_17235 ENOG4107VFR oxidoreductase HT135_17255 ENOG4105DIW FeS assembly protein SUFB HT135_17260 ENOG4108UNV SUF system FeS assembly protein, NifU family HT135_17265 ENOG4105C9B Cysteine desulfurase HT135_17270 ENOG4105JRK feS assembly protein SufD HT135_17275 ENOG4105C3K feS assembly ATPase SufC HT135_17290 ENOG4105D01 (LipO)protein HT135_17295 ENOG4108UMI ABC transporter, permease HT135_17300 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HT135_17325 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HT135_17330 ENOG41080E8 Transcriptional regulator, Spx MgsR family HT135_17335 ENOG4105C1G acyl-Coa dehydrogenase HT135_17340 ENOG4105CHU acetyl-coa acetyltransferase HT135_17370 ENOG41067TZ transcriptional regulator, MarR family HT135_17375 ENOG4105C0R drug resistance transporter emrb qaca subfamily HT135_17380 ENOG4105MDS 4-oxalocrotonate tautomerase HT135_17390 ENOG4105EGI Transcriptional regulator HT135_17400 ENOG4105E0A ABC, transporter HT135_17415 ENOG4105E1F short-chain dehydrogenase reductase HT135_17420 ENOG4105HUF DNA protection during starvation protein HT135_17425 ENOG4105C0H protease HT135_17435 ENOG4105F3H Histidine kinase HT135_17445 ENOG41067SE Tetr family transcriptional regulator HT135_17450 ENOG4105C9Q fumarate hydratase class II HT135_17475 ENOG4105WH1 Two component transcriptional regulator luxr family HT135_17480 ENOG4105ENE Histidine kinase HT135_17495 ENOG41087YS Phage shock protein A HT135_17510 ENOG4108WBT adenosyltransferase HT135_17515 ENOG4105E0A ABC, transporter HT135_17520 ENOG4105EHG Permease protein HT135_17525 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HT135_17530 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HT135_17535 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HT135_17545 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HT135_17555 ENOG4106DF4 Sigma-70, region 4 HT135_17565 ENOG4105F0F Oxalate decarboxylase HT135_17575 ENOG4107RBB ABC transporter, permease HT135_17580 ENOG4105C19 ABC transporter HT135_17585 ENOG4108WMK Efflux transporter RND family MFP subunit HT135_17590 ENOG4105E0A ABC, transporter HT135_17595 ENOG4105EHG Permease protein HT135_17600 ENOG4105DQ5 transport system permease protein HT135_17610 ENOG4105D5Q Arginine ornithine antiporter HT135_17620 ENOG4107K5X Membrane-bound metal-dependent hydrolase HT135_17625 ENOG4107QZ2 Sulfatase HT135_17630 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family HT135_17635 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HT135_17640 ENOG4105E0C molybdate abc transporter HT135_17655 ENOG4105EEQ Na H antiporter HT135_17660 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HT135_17665 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HT135_17670 ENOG4105EEM helicase HT135_17680 ENOG4105EN6 Membrane HT135_17690 ENOG4107ZQN disulfide bond HT135_17695 ENOG4105C59 p-type ATPase HT135_17700 ENOG4105C59 p-type ATPase HT135_17705 ENOG410681U heavy metal transport detoxification protein HT135_17710 ENOG4105VPX protein, conserved in bacteria HT135_17715 ENOG4105D9R oxidoreductase HT135_17720 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HT135_17725 ENOG4105ME7 Membrane HT135_17730 ENOG4105DRR Transcriptional regulator, GntR family HT135_17735 ENOG4108UZ3 Transporter HT135_17740 ENOG4105RXJ HT135_17745 ENOG4105KPY Small multidrug resistance protein HT135_17750 ENOG4105KBX Transcriptional regulator, TetR family HT135_17755 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HT135_17765 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HT135_17770 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HT135_17780 ENOG4105XZU Preprotein translocase, subunit SecG HT135_17805 ENOG4105KVH Transcriptional regulator HT135_17810 ENOG4105C8Q Methyl-accepting chemotaxis HT135_17815 ENOG4105R40 Glycine betaine carnitine choline HT135_17820 ENOG4108HQR Glycine betaine HT135_17825 ENOG4105E90 ABC transporter HT135_17830 ENOG4108IJ8 ABC transporter HT135_17835 ENOG4107HG4 Transcriptional regulator HT135_17845 ENOG4105H5S HT135_17860 ENOG41082BM Transcriptional regulator, arsr family HT135_17865 ENOG4105R40 Glycine betaine carnitine choline HT135_17870 ENOG4108HQR Glycine betaine HT135_17875 ENOG4105E90 ABC transporter HT135_17880 ENOG4108IJ8 ABC transporter HT135_17885 ENOG4107HG4 Transcriptional regulator HT135_17890 ENOG4108QCI YvbH-like oligomerisation region HT135_17900 ENOG4105T65 Membrane-associated protein HT135_17905 ENOG4108W0I acetyltransferase HT135_17920 ENOG4105FJR Lmbe family HT135_17940 ENOG4108IAJ Nad-dependent epimerase dehydratase HT135_17945 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HT135_17950 ENOG4107QQG Dehydrogenase HT135_17955 ENOG4105IIU Aminopeptidase HT135_17960 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HT135_17965 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HT135_17970 ENOG4105CP7 Triose-phosphate isomerase HT135_17975 ENOG4105BZA Phosphoglycerate kinase HT135_17980 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HT135_17995 ENOG4105CMD Transcriptional regulator, GntR family HT135_18000 ENOG4105DEN Luciferase family HT135_18005 ENOG4105GZI Transcriptional regulator HT135_18010 ENOG4107RT3 EamA-like transporter family HT135_18020 ENOG4105VRS hydrolase family 18 HT135_18025 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HT135_18030 ENOG4107QR9 Iron-sulfur cluster binding protein HT135_18035 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HT135_18045 ENOG4105BZU Histidine kinase HT135_18050 ENOG4105KCT ABC transporter HT135_18055 ENOG4108M15 ABC transporter HT135_18060 ENOG4107R6F Alpha Beta Hydrolase Fold protein HT135_18065 ENOG4108MJI response regulator HT135_18080 ENOG4105EG2 ABC transporter, permease HT135_18090 ENOG4107FKK extracellular solute-binding protein family 1 HT135_18100 ENOG4105JXH GntR family transcriptional regulator HT135_18105 ENOG4105DAA L-lactate HT135_18110 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HT135_18120 ENOG4108ZPC Polysaccharide pyruvyl transferase HT135_18125 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HT135_18130 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family HT135_18135 ENOG4105D3Q Sugar transferase HT135_18145 ENOG4105K64 Glycosyl transferase, family 2 HT135_18155 ENOG4107QRS glycosyltransferase group 2 family protein HT135_18160 ENOG41068W6 Capsular polysaccharide biosynthesis protein HT135_18165 ENOG4108KMV Glycosyl transferase (Group 1 HT135_18170 ENOG4105K64 Glycosyl transferase, family 2 HT135_18175 ENOG4108PQP glycosyl transferase group 1 HT135_18185 ENOG4108QV3 biosynthesis protein HT135_18190 ENOG4105HTX biosynthesis protein HT135_18200 ENOG4105EBR Carboxylesterase HT135_18210 ENOG4105PY6 Phenolic acid decarboxylase HT135_18215 ENOG4105NI3 Protein of unknown function (DUF3237) HT135_18225 ENOG4105FQP Beta-lactamase HT135_18235 ENOG4108UXE Protein tyrosine phosphatase HT135_18240 ENOG4107R5R arsenical pump membrane protein HT135_18245 ENOG41082YX Transcriptional regulator, arsr family HT135_18250 ENOG4105EDQ levansucrase EC 2.4.1.10 HT135_18255 ENOG4108HKT sucrose-6-phosphate hydrolase HT135_18260 ENOG4107QTZ amino acid HT135_18290 ENOG4105DNP FAD linked oxidase domain protein HT135_18295 ENOG4105IRW patatin-like phospholipase family protein HT135_18305 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HT135_18310 ENOG4108URH decarboxylase HT135_18315 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain HT135_18320 ENOG4105CHH sulfate transporter HT135_18325 ENOG4108V2W Carbonate dehydratase HT135_18330 ENOG4105C5I Dehydrogenase HT135_18340 ENOG4105C19 ABC transporter HT135_18345 ENOG4105EWM Histidine kinase HT135_18355 ENOG4107A6P HT135_18360 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HT135_18365 ENOG4105KRI phosphocarrier protein (HPr HT135_18370 ENOG4105CIE May be required for sporulation (By similarity) HT135_18375 ENOG4105CHW UPF0052 protein HT135_18380 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HT135_18385 ENOG4108Z4K mutator MutT protein HT135_18390 ENOG4105C3M thioredoxin reductase HT135_18405 ENOG4105BZ1 (ABC) transporter HT135_18415 ENOG4106FGC HT135_18425 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HT135_18430 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HT135_18435 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HT135_18440 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HT135_18445 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HT135_18450 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HT135_18455 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HT135_18460 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) HT135_18470 ENOG4108E16 pectate lyase HT135_18475 ENOG4108S4C acetyltransferase HT135_18480 ENOG4107XGZ Hydrolase HT135_18485 ENOG4105HKU nucleoside recognition domain-containing protein HT135_18490 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HT135_18495 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) HT135_18500 ENOG4105CE4 GlcNAc 6-P deacetylase HT135_18505 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HT135_18515 ENOG41088CQ domain protein HT135_18535 ENOG41086DT Membrane protein of unknown function HT135_18540 ENOG41067S9 phage shock protein C, PspC HT135_18545 ENOG4108PY7 HT135_18560 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HT135_18565 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HT135_18580 ENOG4105MKU Transcriptional regulator HT135_18600 ENOG4105CN1 protease HT135_18605 ENOG4105CRP Part of the ABC transporter FtsEX involved in HT135_18610 ENOG4105CAK Cell division ATP-binding protein ftsE HT135_18635 ENOG4105MS2 ribosomal subunit Interface protein HT135_18650 ENOG4105MQ3 flagellar protein FliS HT135_18655 ENOG4107RT6 flagellar hook-associated HT135_18660 ENOG41083S7 flagellar protein FlaG HT135_18665 ENOG4105I03 Flagellin HT135_18670 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HT135_18675 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) HT135_18680 ENOG4105MKD HT135_18685 ENOG4105DTJ flagellar hook-associated protein HT135_18690 ENOG4105E1Q flagellar hook-associated protein HT135_18705 ENOG4105RU3 HT135_18710 ENOG41081UC Inherit from COG: Competence protein HT135_18730 ENOG4105WH1 Two component transcriptional regulator luxr family HT135_18735 ENOG4105BZU Histidine kinase HT135_18740 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HT135_18745 ENOG4108KGH TRANSCRIPTIONal HT135_18750 ENOG4105ESV Glycosyl transferase, family 4 HT135_18755 ENOG4107EF8 Glycosyl transferase (Group 1 HT135_18770 ENOG4105QZI O-Antigen Polymerase HT135_18775 ENOG4105C6Y Udp-glucose 6-dehydrogenase HT135_18780 ENOG4107RA4 Glycosyl transferase (Group 1 HT135_18785 ENOG4105PSV Polysaccharide Biosynthesis Protein HT135_18790 ENOG4105D3Q Sugar transferase HT135_18795 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HT135_18800 ENOG4105JFG SpoIID LytB domain protein HT135_18815 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HT135_18830 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) HT135_18835 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HT135_18840 ENOG4105EY8 ABC transporter HT135_18865 ENOG41088M2 Glycosyl transferase family 2 HT135_18915 ENOG4105DG6 mannose-6-phosphate isomerase HT135_18930 ENOG4108NHD germination protein HT135_18935 ENOG4105C54 Major Facilitator superfamily HT135_18940 ENOG4108KGH TRANSCRIPTIONal HT135_18945 ENOG4105J7I hydrolase HT135_18950 ENOG4105K4H Nlp p60 protein HT135_18960 ENOG4105PNM synthesis protein HT135_18970 ENOG4105N98 Capsule biosynthesis protein capB HT135_18975 ENOG4105ETE Transcriptional regulator (LacI family HT135_18980 ENOG4108RVA ribokinase HT135_18985 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HT135_18990 ENOG4105C2J ABC transporter HT135_18995 ENOG4105CNN ABC, transporter HT135_19000 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HT135_19015 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HT135_19020 ENOG4107FQX Alpha-acetolactate decarboxylase HT135_19030 ENOG4107RSM transcriptional regulator HT135_19045 ENOG4106UIA HT135_19045 ENOG4106UIA HT135_19060 ENOG4107XC4 flavin reductase domain protein, FMN-binding HT135_19065 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HT135_19080 ENOG4105UP7 3-epimerase HT135_19090 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HT135_19100 ENOG4105CAH Chromate HT135_19105 ENOG4105FGV Chromate HT135_19115 ENOG4108WS4 fmn reductase HT135_19120 ENOG4107V2S Transcriptional regulator HT135_19125 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HT135_19180 ENOG4105C6Y Udp-glucose 6-dehydrogenase HT135_19185 ENOG4108RB3 Capsular polysaccharide biosynthesis protein HT135_19190 ENOG4107YJ4 chain length determinant protein HT135_19195 ENOG4105HTX biosynthesis protein HT135_19205 ENOG4105KBK Zinc finger, swim domain protein HT135_19210 ENOG4105C0D helicase HT135_19215 ENOG410667J hydrolase HT135_19220 ENOG4105E98 transcriptional regulator DeoR family HT135_19225 ENOG4105Z8H single-stranded DNA-binding protein HT135_19240 ENOG4108HWY Beta-lactamase HT135_19245 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HT135_19250 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HT135_19260 ENOG4105CGA flagellar basal-body rod protein FlgG HT135_19270 ENOG4105DFF Rod shape-determining protein mreb HT135_19275 ENOG4105MT0 Sporulation transcriptional regulator spoiiid HT135_19285 ENOG4107MII Sugar-specific transcriptional regulator TrmB HT135_19290 ENOG4105CZM Major Facilitator HT135_19295 ENOG4108M26 parallel beta-helix repeat protein HT135_19300 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HT135_19305 ENOG41080V3 Major Facilitator superfamily HT135_19310 ENOG4105D3W isochorismatase HT135_19315 ENOG4107P26 HT135_19320 ENOG4105BZU Histidine kinase HT135_19330 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HT135_19340 ENOG4105FRN stage II sporulation protein HT135_19345 ENOG4107TCE N-acetyltransferase HT135_19360 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HT135_19365 ENOG4106BRK HT135_19370 ENOG4108RYK Nad-dependent epimerase dehydratase HT135_19375 ENOG4108Z40 Transcriptional regulator HT135_19380 ENOG4105CQM Urea amidohydrolase subunit alpha HT135_19385 ENOG4105KI2 Urea amidohydrolase subunit beta HT135_19390 ENOG4108YZ9 Urea amidohydrolase subunit gamma HT135_19395 ENOG4108IV0 ABC, transporter HT135_19400 ENOG4105C0Z ABC transporter HT135_19410 ENOG4105C32 Amino acid ABC transporter (Permease) HT135_19415 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein HT135_19440 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HT135_19450 ENOG4108TF4 von Willebrand factor, type A HT135_19460 ENOG4105JFG SpoIID LytB domain protein HT135_19465 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HT135_19475 ENOG4106778 Protein of unknown function (DUF1146) HT135_19485 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HT135_19490 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HT135_19495 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HT135_19500 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HT135_19520 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) HT135_19530 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HT135_19535 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HT135_19540 ENOG4108UIC UPF0340 protein HT135_19545 ENOG4108YZG isomerase HT135_19550 ENOG4107WAU Protein tyrosine phosphatase HT135_19555 ENOG410815N Probably functions as a manganese efflux pump (By similarity) HT135_19560 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HT135_19570 ENOG4108ZXQ stage ii sporulation protein r HT135_19585 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HT135_19590 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HT135_19595 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HT135_19605 ENOG4107TT2 Auxin Efflux Carrier HT135_19610 ENOG4105C6K Malic enzyme HT135_19615 ENOG4107104 thymidine kinase HT135_19625 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HT135_19635 ENOG4105CBT Fructose-1,6-bisphosphatase HT135_19640 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HT135_19645 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway HT135_19650 ENOG4105D2N Aldolase HT135_19655 ENOG410812K response regulator receiver protein HT135_19665 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HT135_19675 ENOG4105C1G acyl-Coa dehydrogenase HT135_19680 ENOG4105DF6 Fe-S oxidoreductase HT135_19690 ENOG4105E5J UV damage endonuclease HT135_19700 ENOG4105NAE bifunctional deaminase-reductase domain protein HT135_19705 ENOG4105BZ1 (ABC) transporter HT135_19710 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HT135_19725 ENOG4105R3A Nitrate reductase HT135_19730 ENOG4108IUE nitrate reductase beta subunit HT135_19750 ENOG4107V6Q Cyclic nucleotide-binding domain HT135_19760 ENOG4105C75 arginyL-tRNA synthetase HT135_19765 ENOG410684U Domain of unknown function (DUF1934) HT135_19775 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E HT135_19820 ENOG4107JM4 Tetratricopeptide repeat HT135_19830 ENOG4105CYW agmatinase HT135_19835 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HT135_19840 ENOG4105BZ4 penicillin-binding protein HT135_19850 ENOG4108XFG YwhD family HT135_19855 ENOG4108Z4T Peptidase M50 HT135_19860 ENOG41069HH 4-oxalocrotonate tautomerase HT135_19865 ENOG41067TZ transcriptional regulator, MarR family HT135_19870 ENOG4105C22 threonyL-tRNA synthetase HT135_19875 ENOG4105C57 major facilitator superfamily HT135_19880 ENOG41062ES Transcriptional regulator HT135_19890 ENOG4105DCI Phosphohydrolase HT135_19900 ENOG4108VCI transcription factor, rsfa family HT135_19905 ENOG4108RNG Permease of the drug metabolite transporter HT135_19910 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) HT135_19915 ENOG4105DUM transcriptional regulator, lysR family HT135_19920 ENOG4108IJ2 phosphate acetyltransferase HT135_19935 ENOG4105CHM Aminotransferase HT135_19945 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase HT135_19950 ENOG4105CHR reductase HT135_19955 ENOG4106CHD Bacilysin biosynthesis protein bacB HT135_19960 ENOG41061WN bacilysin biosynthesis protein HT135_19965 ENOG4105FCW Major Facilitator superfamily HT135_19985 ENOG4105C26 Dehydrogenase HT135_19990 ENOG4105D82 Glutamate dehydrogenase HT135_20000 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase HT135_20005 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HT135_20010 ENOG4105C1B dTDP-glucose 4-6-dehydratase HT135_20015 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HT135_20020 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG HT135_20025 ENOG4107TY6 Acylneuraminate cytidylyltransferase HT135_20035 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD HT135_20040 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HT135_20075 ENOG4105C26 Dehydrogenase HT135_20080 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HT135_20085 ENOG4108RJ9 Glycosyl transferase, family 2 HT135_20105 ENOG4105DWF phosphomethylpyrimidine kinase HT135_20120 ENOG4105C5Y PTS System HT135_20125 ENOG4108QTI )-transporter HT135_20140 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin HT135_20145 ENOG4105DEN Luciferase family HT135_20150 ENOG4108DBC nitroreductase HT135_20175 ENOG4105BZ9 Cytochrome C oxidase, subunit I HT135_20180 ENOG4105E2S oxidase) subunit II HT135_20185 ENOG4107BMA Transglycosylase associated protein HT135_20195 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HT135_20200 ENOG4105WH5 Teichoic acid glycosylation protein HT135_20225 ENOG4107ZXU DSBA oxidoreductase HT135_20230 ENOG4105DBE peroxidase HT135_20235 ENOG410650H (LipO)protein HT135_20240 ENOG4107SJW iron permease, FTR1 HT135_20245 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HT135_20255 ENOG4105CMU LysR family (Transcriptional regulator HT135_20260 ENOG4105VAW lrga family HT135_20265 ENOG41067MG lrgb family HT135_20270 ENOG4105D8G Major Facilitator superfamily HT135_20280 ENOG4105DR4 Methyltransferase HT135_20290 ENOG4108YV3 Protein of unknown function (DUF2711) HT135_20295 ENOG4105CK1 PTS System HT135_20300 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin HT135_20315 ENOG4105X1N Glycosyl transferase family 8 HT135_20325 ENOG4105GVJ transcriptional regulator HT135_20330 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HT135_20335 ENOG4105IIU Aminopeptidase HT135_20345 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HT135_20355 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) HT135_20360 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HT135_20370 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HT135_20375 ENOG4108VHC Short-chain dehydrogenase reductase Sdr HT135_20380 ENOG4105CM2 brancheD-chain amino acid aminotransferase HT135_20385 ENOG4105F8D glycoside hydrolase family 4 HT135_20390 ENOG4105VCP PTS System HT135_20395 ENOG4105CK1 PTS System HT135_20400 ENOG4105VZJ PTS System HT135_20405 ENOG4105EMD TRANSCRIPTIONal HT135_20415 ENOG4108VX5 3-methyladenine DNA glycosylase HT135_20420 ENOG4105CH6 catalase HT135_20435 ENOG4105DA5 (ABC) transporter HT135_20440 ENOG41069JR HT135_20460 ENOG4105ETS cytosine purines uracil thiamine allantoin HT135_20465 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HT135_20470 ENOG4108JJ8 (ABC) transporter HT135_20475 ENOG4108JJ9 ABC, transporter HT135_20480 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HT135_20485 ENOG4105C4M (Ubiquinol oxidase) subunit I HT135_20490 ENOG4105D2K citrate carrier protein HT135_20505 ENOG4107BJW polysaccharide deacetylase HT135_20525 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HT135_20535 ENOG4105CMR udp-glucose 4-epimerase HT135_20545 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HT135_20570 ENOG4108JUB Transcriptional regulator HT135_20575 ENOG4105DTD Dehydrogenase HT135_20580 ENOG4108IIH CoA-transferase subunit B HT135_20585 ENOG4105D6N CoA-transferase, subunit a HT135_20590 ENOG4105CY2 Citrate transporter HT135_20595 ENOG4105DHI Methyltransferase HT135_20615 ENOG4105CH6 catalase HT135_20620 ENOG4105D4T Citrate transporter HT135_20630 ENOG4105CS2 ec 3.2.1.21 HT135_20635 ENOG4105C5Y PTS System HT135_20640 ENOG4105CID antiterminator HT135_20650 ENOG4105DEU major facilitator superfamily HT135_20655 ENOG4105C1J atp-dependent rna helicase HT135_20660 ENOG4107TDE lipolytic protein G-D-S-L family HT135_20720 ENOG4107YZX Universal stress protein HT135_20725 ENOG4105CS2 ec 3.2.1.21 HT135_20730 ENOG4105C5Y PTS System HT135_20750 ENOG4107EV6 Inherit from COG: YD repeat protein HT135_20785 ENOG4106Z5D Glycoside Hydrolase Family 43 HT135_20800 ENOG4105C84 Histidine ammonia-lyase HT135_20805 ENOG4105CGP Urocanate hydratase HT135_20810 ENOG4105CI2 imidazolone-5-propionate hydrolase HT135_20815 ENOG4107W25 arginase agmatinase formiminoglutamase HT135_20825 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HT135_20830 ENOG4105D9N nucleoside HT135_20840 ENOG4107RHR regulatoR HT135_20845 ENOG4108TM9 integral membrane protein HT135_20850 ENOG4105ENY Ethanolamine utilization protein eutH HT135_20855 ENOG4108PGP mmge prpd family protein HT135_20870 ENOG4108HW4 amino acid AbC transporter HT135_20875 ENOG4105EAB amino acid AbC transporter HT135_20895 ENOG4107QHE Choloylglycine hydrolase HT135_20900 ENOG410667J hydrolase HT135_20930 ENOG4108V5C ABC transporter HT135_20960 ENOG4105D2N Aldolase HT135_20965 ENOG4105WZ4 isomerase HT135_20970 ENOG4105F0H myo-inositol catabolism protein HT135_20975 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HT135_20985 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HT135_20990 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HT135_20995 ENOG4105D7K pfkb domain protein HT135_21005 ENOG4105C26 Dehydrogenase HT135_21015 ENOG4105CPC Aldo Keto reductase HT135_21040 ENOG4107QNK )-transporter HT135_21045 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HT135_21055 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HT135_21060 ENOG4105ST3 Transcriptional regulator HT135_21065 ENOG4105C26 Dehydrogenase HT135_21070 ENOG41085PJ rdd domain containing protein HT135_21075 ENOG4108ITS PQQ enzyme repeat HT135_21085 ENOG41085PJ rdd domain containing protein HT135_21100 ENOG4105J7D transcriptional regulator HT135_21105 ENOG4107JEE Short-chain dehydrogenase reductase Sdr HT135_21110 ENOG41061AU MarR family Transcriptional regulator HT135_21120 ENOG41067MG lrgb family HT135_21150 ENOG4105BZW Glycerate kinase HT135_21155 ENOG4105G3Z GntR family transcriptional regulator HT135_21160 ENOG4105CMG Carbohydrate kinase HT135_21165 ENOG4105C6Z Gluconate HT135_21170 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HT135_21175 ENOG4105D3R alkyl hydroperoxide reductase HT135_21180 ENOG4108JU3 Alkyl hydroperoxide reductase HT135_21185 ENOG4105CS2 ec 3.2.1.21 HT135_21195 ENOG4108S3Y transcriptional regulator HT135_21205 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 HT135_21240 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) HT135_21255 ENOG4105E2A Dehydrogenase HT135_21275 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) HT135_21280 ENOG4105WQG acetyltransferase HT135_21285 ENOG410780I phosphoprotein phosphatase activity HT135_21295 ENOG41066UZ arginase EC 3.5.3.1 HT135_21300 ENOG4108IQI permease HT135_21305 ENOG4105C8Y Acetylornithine aminotransferase HT135_21310 ENOG4108JUB Transcriptional regulator HT135_21315 ENOG4105C0H protease HT135_21320 ENOG4105Q2H domain protein HT135_21335 ENOG4105BZU Histidine kinase HT135_21340 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HT135_21365 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HT135_21370 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase HT135_21375 ENOG4105CDU Replicative dna helicase HT135_21395 ENOG4105DJ2 Major Facilitator Superfamily HT135_21400 ENOG4105EDW glycosyl transferase, family 39 HT135_21405 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HT135_21410 ENOG4105BZR domain protein HT135_21415 ENOG4108XMW Membrane HT135_21430 ENOG4105KVH Transcriptional regulator HT135_21435 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase HT135_21460 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein HT135_21470 ENOG4105D94 Major Facilitator Superfamily HT135_21475 ENOG4107RSM transcriptional regulator HT135_21480 ENOG41082BV acetyltransferase HT135_21485 ENOG41081I9 integral membrane protein HT135_21490 ENOG4107V2S Transcriptional regulator HT135_21495 ENOG4108VP3 Lysine exporter protein (LysE YggA) HT135_21500 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase HT135_21515 ENOG4108ZHR arsR family transcriptional regulator HT135_21520 ENOG4108SQ9 flavin reductase domain protein, FMN-binding HT135_21530 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HT135_21545 ENOG4108IXY short-chain dehydrogenase reductase HT135_21555 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HT135_21565 ENOG4105M4P Tetr family transcriptional regulator HT135_21585 ENOG4108Z5V transcriptional regulator, merr family HT135_21590 ENOG4108UQV Membrane HT135_21595 ENOG41086D8 Transcriptional regulator HT135_21615 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HT135_21620 ENOG4105C7Z Conserved Protein HT135_21640 ENOG4105MSY salicylate hydroxylase HT135_21645 ENOG41068WC Domain of unknown function (DUF955) HT135_21680 ENOG4105C7Z Conserved Protein HT135_21685 ENOG4107FCW Abortive infection protein HT135_21695 ENOG4108UW5 maltose o-acetyltransferase HT135_21700 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HT135_21710 ENOG4105CGK Exodeoxyribonuclease III HT135_21715 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HT135_21720 ENOG4108UUM single-stranded DNA-binding protein HT135_21725 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HT135_21730 ENOG4105C3G gtp-binding protein HT135_21735 ENOG4108J2R molybdopterin oxidoreductase HT135_21740 ENOG4105VDK protein, conserved in bacteria HT135_21750 ENOG4108ZDA Sporulation protein YyaC HT135_21755 ENOG4105FA0 parb-like partition protein HT135_21760 ENOG4107QJE Chromosome Partitioning Protein HT135_21775 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HT135_21780 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HT135_21785 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HT135_21800 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)