locus-tag	class	description
HT135_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HT135_00010	COG0592	DNA-directed DNA polymerase activity
HT135_00015	COG2501	S4 domain
HT135_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HT135_00030	COG0187	DNA topoisomerase II activity
HT135_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HT135_00075	COG0517	IMP dehydrogenase activity
HT135_00075	COG0516	GMP reductase activity
HT135_00080	COG1686	Belongs to the peptidase S11 family
HT135_00090	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HT135_00095	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HT135_00105	COG1428	Deoxynucleoside kinase
HT135_00110	COG1428	Deoxynucleoside kinase
HT135_00115	COG3858	chitin binding
HT135_00115	COG1388	LysM domain
HT135_00120	COG1335	isochorismatase
HT135_00125	COG0590	tRNA wobble adenosine to inosine editing
HT135_00135	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HT135_00140	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HT135_00145	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HT135_00190	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HT135_00195	COG3853	Toxic anion resistance protein (TelA)
HT135_00200	COG1982	Orn Lys Arg decarboxylase major
HT135_00205	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HT135_00210	COG3870	Protein conserved in bacteria
HT135_00215	COG1728	Protein conserved in bacteria
HT135_00220	COG0470	DNA polymerase III
HT135_00225	COG1774	PSP1 C-terminal conserved region
HT135_00235	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HT135_00240	COG2827	Endonuclease containing a URI domain
HT135_00245	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HT135_00250	COG2002	toxin-antitoxin pair type II binding
HT135_00255	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HT135_00255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HT135_00260	COG0084	hydrolase, TatD family'
HT135_00265	COG3584	3D domain protein
HT135_00265	COG3583	domain protein
HT135_00270	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HT135_00275	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HT135_00285	COG4466	Protein conserved in bacteria
HT135_00295	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HT135_00300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HT135_00305	COG0251	oxidation-reduction process
HT135_00310	COG2088	sporulation resulting in formation of a cellular spore
HT135_00315	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HT135_00320	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HT135_00325	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HT135_00330	COG0193	aminoacyl-tRNA hydrolase activity
HT135_00340	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HT135_00345	COG2002	toxin-antitoxin pair type II binding
HT135_00350	COG2244	polysaccharide biosynthetic process
HT135_00355	COG3956	TIGRFAM MazG family protein
HT135_00360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HT135_00375	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HT135_00380	COG1098	S1 RNA binding domain
HT135_00395	COG2208	phosphoserine phosphatase activity
HT135_00400	COG2304	oxidoreductase activity
HT135_00405	COG0515	serine threonine protein kinase
HT135_00410	COG0037	tRNA processing
HT135_00420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HT135_00425	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HT135_00430	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HT135_00435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HT135_00440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HT135_00445	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HT135_00450	COG0512	Glutamine amidotransferase of anthranilate synthase
HT135_00455	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HT135_00460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HT135_00465	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HT135_00470	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HT135_00475	COG1396	sequence-specific DNA binding
HT135_00480	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HT135_00485	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HT135_00565	COG4463	regulation of RNA biosynthetic process
HT135_00570	COG3880	PFAM UvrB UvrC protein
HT135_00575	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HT135_00580	COG0542	response to heat
HT135_00585	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HT135_00590	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HT135_00595	COG4956	integral membrane protein (PIN domain superfamily)
HT135_00600	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HT135_00605	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HT135_00610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HT135_00615	COG1045	serine acetyltransferase
HT135_00620	COG0215	cysteine-tRNA ligase activity
HT135_00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HT135_00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HT135_00635	COG3688	RNA-binding protein containing a PIN domain
HT135_00640	COG1595	DNA-templated transcription, initiation
HT135_00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HT135_00655	COG0250	Participates in transcription elongation, termination and antitermination
HT135_00665	COG0081	regulation of translation
HT135_00680	COG2813	Specifically methylates the guanine in position
HT135_00685	COG0085	RNA polymerase activity
HT135_00690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HT135_00695	COG1358	cellular component organization or biogenesis
HT135_00705	COG0049	tRNA binding
HT135_00710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HT135_00715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HT135_00720	COG0596	Alpha beta hydrolase
HT135_00730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HT135_00745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HT135_00765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HT135_00775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HT135_00780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HT135_00790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HT135_00800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HT135_00805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HT135_00810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HT135_00825	COG0200	Binds to the 23S rRNA
HT135_00830	COG0201	protein transport
HT135_00835	COG0563	adenylate kinase activity
HT135_00840	COG0024	Methionine aminopeptidase
HT135_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HT135_00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HT135_00865	COG0202	RNA polymerase activity
HT135_00870	COG0203	ribosomal protein L17
HT135_00875	COG1122	ATPase activity
HT135_00880	COG1122	ATPase activity
HT135_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HT135_00890	COG0101	tRNA pseudouridine synthase activity
HT135_00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HT135_00905	COG2226	methyltransferase
HT135_00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
HT135_00920	COG0489	protein tyrosine kinase activity
HT135_00930	COG2194	sulfuric ester hydrolase activity
HT135_00935	COG0726	polysaccharide deacetylase
HT135_01015	COG0659	secondary active sulfate transmembrane transporter activity
HT135_01020	COG0385	Bile acid
HT135_01025	COG2819	hydrolase of the alpha beta superfamily
HT135_01030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HT135_01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HT135_01040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HT135_01045	COG2207	Transcriptional regulator
HT135_01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HT135_01050	COG3876	Protein conserved in bacteria
HT135_01055	COG1472	Belongs to the glycosyl hydrolase 3 family
HT135_01060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HT135_01065	COG1263	PTS System
HT135_01065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT135_01070	COG1737	Transcriptional regulator
HT135_01075	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HT135_01080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HT135_01085	COG1683	Conserved Protein
HT135_01115	COG1595	DNA-templated transcription, initiation
HT135_01120	COG5662	AntiSigma factor
HT135_01125	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HT135_01130	COG4856	YbbR-like protein
HT135_01135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HT135_01145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HT135_01150	COG3002	Belongs to the UPF0753 family
HT135_01155	COG0288	reversible hydration of carbon dioxide
HT135_01165	COG5609	conserved protein (DUF2294)
HT135_01170	COG0640	Transcriptional regulator
HT135_01175	COG2814	Major facilitator Superfamily
HT135_01180	COG1413	lyase activity
HT135_01190	COG0596	Alpha beta hydrolase
HT135_01195	COG0745	RESPONSE REGULATOR receiver
HT135_01200	COG0642	Histidine kinase
HT135_01210	COG0515	serine threonine protein kinase
HT135_01225	COG1113	amino acid transport
HT135_01240	COG2602	Beta-lactamase
HT135_01245	COG2124	cytochrome p450
HT135_01255	COG0531	amino acid
HT135_01260	COG0584	glycerophosphoryl diester phosphodiesterase
HT135_01265	COG2271	Major facilitator Superfamily
HT135_01275	COG1846	Transcriptional regulator
HT135_01275	COG0456	acetyltransferase
HT135_01280	COG2271	Major facilitator Superfamily
HT135_01290	COG0697	spore germination
HT135_01295	COG2207	Transcriptional regulator
HT135_01295	COG1917	Cupin 2, conserved barrel domain protein
HT135_01300	COG0371	Dehydrogenase
HT135_01305	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HT135_01310	COG3591	Belongs to the peptidase S1B family
HT135_01320	COG0596	Alpha beta hydrolase
HT135_01325	COG1183	phosphatidylcholine synthase activity
HT135_01330	COG0586	Pfam SNARE associated Golgi protein
HT135_01335	COG0688	phosphatidylethanolamine metabolic process
HT135_01345	COG2312	Erythromycin esterase
HT135_01360	COG1301	dicarboxylic acid transport
HT135_01365	COG2190	(PTS) system
HT135_01365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT135_01365	COG1263	PTS System
HT135_01370	COG0363	glucosamine-6-phosphate deaminase activity
HT135_01375	COG2188	Transcriptional regulator
HT135_01385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HT135_01390	COG0833	amino acid
HT135_01395	COG2040	homocysteine
HT135_01400	COG1115	amino acid carrier protein
HT135_01405	COG2066	Belongs to the glutaminase family
HT135_01410	COG4191	Histidine kinase
HT135_01415	COG0784	Response regulator, receiver
HT135_01420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HT135_01425	COG1012	belongs to the aldehyde dehydrogenase family
HT135_01430	COG2271	Major facilitator Superfamily
HT135_01435	COG4948	Mandelate Racemase Muconate Lactonizing
HT135_01440	COG2186	Transcriptional regulator
HT135_01445	COG2721	sulfolactate sulfo-lyase activity
HT135_01450	COG3173	Aminoglycoside phosphotransferase
HT135_01460	COG0745	RESPONSE REGULATOR receiver
HT135_01465	COG2205	protein histidine kinase activity
HT135_01470	COG1131	(ABC) transporter
HT135_01490	COG3773	Cell wall hydrolase
HT135_01495	COG2304	oxidoreductase activity
HT135_01505	COG3540	Alkaline phosphatase
HT135_01510	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HT135_01515	COG0805	protein transport
HT135_01520	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HT135_01525	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HT135_01530	COG0477	Major facilitator Superfamily
HT135_01535	COG1309	transcriptional regulator
HT135_01540	COG0252	asparaginase activity
HT135_01545	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HT135_01550	COG1714	RDD family
HT135_01555	COG3012	SEC-C Motif Domain Protein
HT135_01555	COG1405	negative regulation of cell septum assembly
HT135_01560	COG3290	protein histidine kinase activity
HT135_01565	COG3279	Response regulator of the LytR AlgR family
HT135_01570	COG4555	ABC transporter
HT135_01575	COG1668	transmembrane transport
HT135_01580	COG0667	Aldo Keto reductase
HT135_01595	COG1595	DNA-templated transcription, initiation
HT135_01600	COG1595	DNA-templated transcription, initiation
HT135_01605	COG1876	peptidase activity
HT135_01610	COG0457	Tetratricopeptide repeat
HT135_01615	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_01620	COG0366	Alpha amylase catalytic
HT135_01625	COG0803	Belongs to the bacterial solute-binding protein 9 family
HT135_01630	COG1121	(ABC) transporter
HT135_01635	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HT135_01640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HT135_01645	COG2310	stress, protein
HT135_01650	COG2310	stress, protein
HT135_01655	COG2310	stress, protein
HT135_01660	COG0861	Integral membrane protein TerC family
HT135_01675	COG1358	cellular component organization or biogenesis
HT135_01690	COG3853	Toxic anion resistance protein (TelA)
HT135_01695	COG0477	Major facilitator Superfamily
HT135_01700	COG2814	Major facilitator Superfamily
HT135_01705	COG0640	Transcriptional regulator
HT135_01710	COG4175	Glycine betaine
HT135_01710	COG0517	IMP dehydrogenase activity
HT135_01715	COG4176	ABC-type proline glycine betaine transport system permease component
HT135_01720	COG2113	Glycine betaine
HT135_01725	COG1473	amidohydrolase
HT135_01730	COG1288	antiporter activity
HT135_01740	COG0366	Alpha amylase catalytic
HT135_01745	COG0039	L-malate dehydrogenase activity
HT135_01750	COG1620	l-lactate permease
HT135_01760	COG2814	Major facilitator Superfamily
HT135_01765	COG1846	Transcriptional regulator
HT135_01770	COG1280	lysine exporter protein (LysE YggA)
HT135_01775	COG3403	YqcI/YcgG family
HT135_01780	COG1113	amino acid transport
HT135_01785	COG3665	Urea carboxylase-associated protein
HT135_01790	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HT135_01795	COG1660	Displays ATPase and GTPase activities
HT135_01805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HT135_01810	COG2226	methyltransferase
HT135_01815	COG0583	DNA-binding transcription factor activity
HT135_01820	COG3458	cephalosporin-C deacetylase activity
HT135_01825	COG3541	Predicted nucleotidyltransferase
HT135_01830	COG0506	proline dehydrogenase activity
HT135_01835	COG1012	belongs to the aldehyde dehydrogenase family
HT135_01840	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HT135_01845	COG2508	Transcriptional regulator
HT135_01850	COG3689	TIGRFAM TIGR03943 family protein
HT135_01855	COG0701	Predicted permease
HT135_01860	COG0492	ferredoxin-NADP+ reductase activity
HT135_01865	COG1587	Uroporphyrinogen-III synthase
HT135_01865	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HT135_01870	COG2146	nitrite reductase [NAD(P)H] activity
HT135_01875	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HT135_01880	COG0243	molybdopterin cofactor binding
HT135_01885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HT135_01890	COG2223	nitrite transmembrane transporter activity
HT135_01895	COG1469	GTP cyclohydrolase I activity
HT135_01900	COG1376	ErfK ybiS ycfS ynhG family protein
HT135_01910	COG0523	cobalamin synthesis protein
HT135_01915	COG0765	amino acid transport
HT135_01920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HT135_01925	COG1063	alcohol dehydrogenase
HT135_01930	COG1714	RDD family
HT135_01940	COG3842	ATPase activity
HT135_01945	COG2723	6-phospho-beta-galactosidase activity
HT135_01955	COG3209	COG3209 Rhs family protein
HT135_01960	COG0840	transmembrane signaling receptor activity
HT135_01960	COG3290	protein histidine kinase activity
HT135_01965	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HT135_01970	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HT135_01975	COG1733	regulation of RNA biosynthetic process
HT135_01980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_01985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_01990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_01995	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HT135_02010	COG0697	spore germination
HT135_02015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HT135_02025	COG2364	Membrane
HT135_02030	COG1126	abc transporter atp-binding protein
HT135_02035	COG0765	amino acid transport
HT135_02040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HT135_02045	COG0583	DNA-binding transcription factor activity
HT135_02050	COG0163	prenyltransferase activity
HT135_02055	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HT135_02070	COG0596	Alpha beta hydrolase
HT135_02075	COG3104	oligopeptide transport
HT135_02080	COG5434	Belongs to the glycosyl hydrolase 28 family
HT135_02090	COG0697	spore germination
HT135_02100	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HT135_02105	COG1136	(ABC) transporter
HT135_02110	COG0577	efflux transmembrane transporter activity
HT135_02115	COG0745	RESPONSE REGULATOR receiver
HT135_02120	COG5002	protein histidine kinase activity
HT135_02120	COG3850	Histidine kinase
HT135_02125	COG0457	Tetratricopeptide repeat
HT135_02145	COG0527	aspartate kinase activity
HT135_02150	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HT135_02155	COG4605	iron ion homeostasis
HT135_02160	COG4604	ABC transporter, ATP-binding protein
HT135_02165	COG4607	ABC-type enterochelin transport system periplasmic component
HT135_02170	COG2814	Major facilitator Superfamily
HT135_02175	COG1309	transcriptional regulator
HT135_02180	COG0778	Nitroreductase
HT135_02185	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HT135_02190	COG0640	Transcriptional regulator
HT135_02195	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HT135_02200	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HT135_02205	COG1012	belongs to the aldehyde dehydrogenase family
HT135_02210	COG4975	Glucose uptake
HT135_02215	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_02220	COG4549	nuclear export factor GLE1
HT135_02225	COG1276	copper resistance
HT135_02225	COG2372	response to copper ion
HT135_02230	COG1349	DNA-binding transcription factor activity
HT135_02240	COG2213	PTS system mannitol-specific
HT135_02245	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT135_02250	COG0246	Mannitol dehydrogenase
HT135_02255	COG0473	3-isopropylmalate dehydrogenase activity
HT135_02260	COG0412	Dienelactone hydrolase
HT135_02265	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HT135_02275	COG0561	phosphatase activity
HT135_02280	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HT135_02285	COG1914	H( )-stimulated, divalent metal cation uptake system
HT135_02290	COG4336	lyase activity
HT135_02295	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HT135_02300	COG1984	allophanate hydrolase subunit 2
HT135_02305	COG1414	Transcriptional regulator
HT135_02310	COG2755	lipolytic protein G-D-S-L family
HT135_02320	COG2329	Antibiotic biosynthesis monooxygenase
HT135_02325	COG0768	penicillin binding
HT135_02330	COG4989	oxidoreductase activity
HT135_02335	COG3711	transcriptional antiterminator
HT135_02340	COG0318	PFAM AMP-dependent synthetase and ligase
HT135_02345	COG2226	methyltransferase
HT135_02350	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_02355	COG1917	Cupin 2, conserved barrel domain protein
HT135_02360	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HT135_02365	COG3871	stress protein (general stress protein 26)
HT135_02375	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HT135_02380	COG2814	Major facilitator Superfamily
HT135_02385	COG1522	sequence-specific DNA binding
HT135_02390	COG0551	DNA topoisomerase type I activity
HT135_02390	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HT135_02395	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HT135_02400	COG3706	GGDEF domain
HT135_02405	COG5298	Protein conserved in bacteria
HT135_02410	COG1215	transferase activity, transferring glycosyl groups
HT135_02420	COG0531	amino acid
HT135_02425	COG0494	nUDIX hydrolase
HT135_02430	COG0028	Belongs to the TPP enzyme family
HT135_02440	COG1914	H( )-stimulated, divalent metal cation uptake system
HT135_02445	COG2261	transglycosylase associated protein
HT135_02450	COG4876	unkown
HT135_02455	COG2217	Heavy metal translocating P-type atpase
HT135_02460	COG3729	General stress protein
HT135_02465	COG0662	Cupin 2, conserved barrel domain protein
HT135_02480	COG3546	catalase activity
HT135_02485	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HT135_02490	COG3290	protein histidine kinase activity
HT135_02495	COG4565	transcriptional regulatory protein
HT135_02500	COG1301	dicarboxylic acid transport
HT135_02505	COG0628	permease
HT135_02510	COG1301	dicarboxylic acid transport
HT135_02515	COG1131	(ABC) transporter
HT135_02520	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HT135_02530	COG1960	acyl-CoA dehydrogenase activity
HT135_02545	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HT135_02550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HT135_02555	COG1181	Belongs to the D-alanine--D-alanine ligase family
HT135_02560	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HT135_02565	COG0513	Belongs to the DEAD box helicase family
HT135_02570	COG3402	PFAM membrane-flanked domain
HT135_02575	COG3428	Bacterial PH domain
HT135_02580	COG0705	Rhomboid family
HT135_02585	COG0736	holo-[acyl-carrier-protein] synthase activity
HT135_02590	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HT135_02595	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HT135_02600	COG0864	Transcriptional regulator
HT135_02605	COG2337	Toxic component of a toxin-antitoxin (TA) module
HT135_02610	COG1366	Belongs to the anti-sigma-factor antagonist family
HT135_02615	COG1366	Belongs to the anti-sigma-factor antagonist family
HT135_02620	COG2172	sigma factor antagonist activity
HT135_02625	COG2208	phosphoserine phosphatase activity
HT135_02630	COG1366	Belongs to the anti-sigma-factor antagonist family
HT135_02635	COG2172	sigma factor antagonist activity
HT135_02640	COG1191	sigma factor activity
HT135_02645	COG2208	phosphoserine phosphatase activity
HT135_02655	COG1673	EVE domain
HT135_02660	COG1846	Transcriptional regulator
HT135_02665	COG2183	response to ionizing radiation
HT135_02675	COG3091	SprT-like family
HT135_02750	COG0604	alcohol dehydrogenase
HT135_02760	COG3239	Fatty acid desaturase
HT135_02765	COG1278	Cold shock
HT135_02770	COG1278	Cold shock
HT135_02775	COG1329	Transcriptional regulator
HT135_02780	COG2315	Protein conserved in bacteria
HT135_02785	COG0346	lactoylglutathione lyase activity
HT135_02805	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HT135_02820	COG2364	Membrane
HT135_02825	COG1846	Transcriptional regulator
HT135_02830	COG0456	acetyltransferase
HT135_02835	COG2808	Putative FMN-binding domain
HT135_02845	COG0697	spore germination
HT135_02850	COG0693	protein deglycase activity
HT135_02865	COG0697	spore germination
HT135_02870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HT135_02875	COG0640	Transcriptional regulator
HT135_02880	COG0346	lactoylglutathione lyase activity
HT135_02890	COG3764	Sortase (surface protein transpeptidase)
HT135_02895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HT135_02905	COG0456	acetyltransferase
HT135_02910	COG0789	Transcriptional regulator
HT135_02910	COG4978	Transcriptional regulator
HT135_02915	COG0702	epimerase
HT135_02925	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT135_02925	COG3711	transcriptional antiterminator
HT135_02930	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HT135_02930	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT135_02930	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HT135_02935	COG1482	cell wall glycoprotein biosynthetic process
HT135_02940	COG2030	dehydratase
HT135_02945	COG0697	spore germination
HT135_02950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HT135_02955	COG0596	Alpha beta hydrolase
HT135_02960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HT135_02975	COG0778	Nitroreductase
HT135_02980	COG0346	lactoylglutathione lyase activity
HT135_02985	COG2259	Doxx family
HT135_02990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HT135_02995	COG1309	transcriptional regulator
HT135_03005	COG0456	acetyltransferase
HT135_03015	COG0673	inositol 2-dehydrogenase activity
HT135_03020	COG1609	Transcriptional regulator
HT135_03025	COG2814	Major facilitator Superfamily
HT135_03030	COG1082	Xylose isomerase domain protein TIM barrel
HT135_03040	COG1113	amino acid transport
HT135_03045	COG2318	DinB family
HT135_03050	COG1846	Transcriptional regulator
HT135_03055	COG1033	growth of symbiont in host cell
HT135_03055	COG2409	Drug exporters of the RND superfamily
HT135_03065	COG0778	Nitroreductase
HT135_03070	COG1846	Transcriptional regulator
HT135_03075	COG1396	sequence-specific DNA binding
HT135_03080	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HT135_03090	COG2814	Major facilitator Superfamily
HT135_03095	COG0730	response to heat
HT135_03100	COG1802	Transcriptional regulator
HT135_03105	COG3858	chitin binding
HT135_03105	COG1388	LysM domain
HT135_03125	COG1785	Belongs to the alkaline phosphatase family
HT135_03130	COG1078	dGTPase activity
HT135_03135	COG1388	LysM domain
HT135_03140	COG2814	Major facilitator Superfamily
HT135_03145	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HT135_03150	COG1447	Phosphotransferase system cellobiose-specific component IIA
HT135_03155	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HT135_03160	COG2723	6-phospho-beta-galactosidase activity
HT135_03165	COG2188	Transcriptional regulator
HT135_03170	COG1940	carbohydrate kinase activity
HT135_03175	COG1482	cell wall glycoprotein biosynthetic process
HT135_03180	COG4124	Belongs to the glycosyl hydrolase 26 family
HT135_03225	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HT135_03230	COG0802	atpase or kinase
HT135_03235	COG1214	PFAM Peptidase M22, glycoprotease
HT135_03240	COG0456	acetyltransferase
HT135_03245	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HT135_03250	COG0488	(ABC) transporter
HT135_03255	COG0315	cyclic pyranopterin monophosphate synthase activity
HT135_03260	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HT135_03265	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HT135_03270	COG0805	protein transport
HT135_03280	COG1266	CAAX protease self-immunity
HT135_03295	COG3409	Peptidoglycan-binding domain 1 protein
HT135_03305	COG0457	Tetratricopeptide repeat
HT135_03310	COG1063	alcohol dehydrogenase
HT135_03315	COG2211	Major facilitator Superfamily
HT135_03320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HT135_03325	COG1842	Phage shock protein A
HT135_03330	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HT135_03335	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HT135_03340	COG4260	virion core protein, lumpy skin disease virus
HT135_03350	COG2814	Major facilitator Superfamily
HT135_03355	COG1063	alcohol dehydrogenase
HT135_03360	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HT135_03365	COG0823	Involved in the tonB-independent uptake of proteins
HT135_03380	COG2267	carboxylic ester hydrolase activity
HT135_03390	COG2132	Multicopper oxidase
HT135_03395	COG1113	amino acid transport
HT135_03400	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HT135_03405	COG0714	Associated with various cellular activities
HT135_03410	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HT135_03415	COG1305	Transglutaminase-like
HT135_03420	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HT135_03420	COG0519	Catalyzes the synthesis of GMP from XMP
HT135_03435	COG2252	PERMEase
HT135_03440	COG3064	Membrane
HT135_03450	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HT135_03460	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HT135_03465	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HT135_03470	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HT135_03475	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HT135_03480	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HT135_03485	COG0047	phosphoribosylformylglycinamidine synthase activity
HT135_03490	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HT135_03495	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HT135_03500	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HT135_03505	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HT135_03510	COG0138	bifunctional purine biosynthesis protein purh
HT135_03515	COG0151	Belongs to the GarS family
HT135_03520	COG1522	sequence-specific DNA binding
HT135_03525	COG0531	amino acid
HT135_03535	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HT135_03540	COG1470	cell adhesion involved in biofilm formation
HT135_03545	COG4496	protein, YerC YecD
HT135_03550	COG0069	glutamate synthase activity
HT135_03555	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HT135_03560	COG0210	DNA helicase
HT135_03565	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HT135_03570	COG4851	CamS sex pheromone cAM373 precursor
HT135_03575	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HT135_03580	COG1285	pathogenesis
HT135_03585	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HT135_03590	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HT135_03595	COG0154	amidase activity
HT135_03600	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HT135_03605	COG1309	transcriptional regulator
HT135_03610	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HT135_03615	COG1597	lipid kinase activity
HT135_03620	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HT135_03635	COG0457	Tetratricopeptide repeat
HT135_03675	COG5444	nuclease activity
HT135_03680	COG3391	amine dehydrogenase activity
HT135_03685	COG0457	Tetratricopeptide repeat
HT135_03695	COG0217	transcriptional regulatory protein
HT135_03710	COG1309	transcriptional regulator
HT135_03715	COG3631	Ketosteroid isomerase-related protein
HT135_03720	COG0702	epimerase
HT135_03725	COG2159	amidohydrolase
HT135_03730	COG1309	transcriptional regulator
HT135_03745	COG3546	catalase activity
HT135_03750	COG0454	-acetyltransferase
HT135_03760	COG5578	integral membrane protein
HT135_03765	COG2972	Histidine kinase
HT135_03770	COG2207	Transcriptional regulator
HT135_03770	COG4753	response regulator
HT135_03775	COG1653	transport
HT135_03780	COG1175	transmembrane transport
HT135_03785	COG0395	ABC-type sugar transport system, permease component
HT135_03790	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HT135_03795	COG2207	Transcriptional regulator
HT135_03800	COG2755	lipolytic protein G-D-S-L family
HT135_03810	COG5578	integral membrane protein
HT135_03815	COG3401	FG-GAP repeat protein
HT135_03820	COG3401	FG-GAP repeat protein
HT135_03825	COG0667	Aldo Keto reductase
HT135_03830	COG2755	lipolytic protein G-D-S-L family
HT135_03835	COG1874	Beta-galactosidase
HT135_03845	COG1653	transport
HT135_03850	COG4209	transmembrane transport
HT135_03855	COG0395	ABC-type sugar transport system, permease component
HT135_03860	COG1486	melibiose metabolic process
HT135_03865	COG2323	membrane
HT135_03870	COG2329	Antibiotic biosynthesis monooxygenase
HT135_03875	COG0346	lactoylglutathione lyase activity
HT135_03885	COG1366	Belongs to the anti-sigma-factor antagonist family
HT135_03890	COG5583	Uncharacterized small protein (DUF2292)
HT135_03895	COG0670	Belongs to the BI1 family
HT135_03900	COG1846	Transcriptional regulator
HT135_03905	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HT135_03915	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HT135_03915	COG2124	cytochrome p450
HT135_03920	COG1368	sulfuric ester hydrolase activity
HT135_03925	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HT135_03930	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HT135_03935	COG1442	glycosyl transferase family 8
HT135_03940	COG1216	Glycosyl transferase, family 2
HT135_03945	COG1442	glycosyl transferase family 8
HT135_03950	COG2223	nitrite transmembrane transporter activity
HT135_03955	COG1011	Hydrolase
HT135_03960	COG0531	amino acid
HT135_03965	COG1012	belongs to the aldehyde dehydrogenase family
HT135_03970	COG0840	transmembrane signaling receptor activity
HT135_03975	COG0488	(ABC) transporter
HT135_03985	COG0789	Transcriptional regulator
HT135_03990	COG2814	Major facilitator Superfamily
HT135_04000	COG0488	(ABC) transporter
HT135_04005	COG0513	Belongs to the DEAD box helicase family
HT135_04010	COG0456	acetyltransferase
HT135_04015	COG2130	NADP-dependent
HT135_04020	COG1120	ATPase activity
HT135_04025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HT135_04030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HT135_04035	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HT135_04050	COG3866	Pectate lyase
HT135_04055	COG0471	metal ion transport
HT135_04075	COG0463	Glycosyl transferase, family 2
HT135_04085	COG3290	protein histidine kinase activity
HT135_04090	COG4565	transcriptional regulatory protein
HT135_04095	COG3181	Tripartite tricarboxylate transporter family receptor
HT135_04100	COG2851	Citrate transporter
HT135_04105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HT135_04110	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HT135_04115	COG1254	Belongs to the acylphosphatase family
HT135_04120	COG2258	MOSC domain
HT135_04140	COG0024	Methionine aminopeptidase
HT135_04145	COG1263	PTS System
HT135_04145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT135_04150	COG1368	sulfuric ester hydrolase activity
HT135_04160	COG1115	amino acid carrier protein
HT135_04165	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT135_04165	COG1263	PTS System
HT135_04170	COG0366	Alpha amylase catalytic
HT135_04175	COG2188	Transcriptional regulator
HT135_04180	COG0778	Nitroreductase
HT135_04185	COG0737	Belongs to the 5'-nucleotidase family
HT135_04190	COG0693	protein deglycase activity
HT135_04195	COG2814	Major facilitator Superfamily
HT135_04200	COG4840	Belongs to the UPF0435 family
HT135_04205	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HT135_04210	COG4980	gas vesicle protein
HT135_04215	COG1295	ribonuclease BN
HT135_04220	COG0477	Major facilitator Superfamily
HT135_04225	COG0387	Pfam Sodium calcium exchanger
HT135_04235	COG0668	transmembrane transport
HT135_04240	COG0535	radical SAM domain protein
HT135_04250	COG0726	polysaccharide deacetylase
HT135_04260	COG2084	Dehydrogenase
HT135_04265	COG0598	Magnesium transport protein CorA
HT135_04270	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HT135_04275	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HT135_04285	COG1132	(ABC) transporter
HT135_04290	COG0515	serine threonine protein kinase
HT135_04300	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HT135_04310	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HT135_04325	COG4637	Psort location Cytoplasmic, score
HT135_04340	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HT135_04345	COG0022	dehydrogenase e1 component
HT135_04350	COG0508	dehydrogenase complex catalyzes the overall conversion of
HT135_04355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HT135_04360	COG3284	Transcriptional regulator
HT135_04370	COG1742	UPF0060 membrane protein
HT135_04395	COG4842	Belongs to the WXG100 family
HT135_04400	COG1486	melibiose metabolic process
HT135_04405	COG1737	Transcriptional regulator
HT135_04410	COG1263	PTS System
HT135_04410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT135_04415	COG1132	(ABC) transporter
HT135_04420	COG1132	(ABC) transporter
HT135_04425	COG2259	Doxx family
HT135_04430	COG2514	catechol 2,3-dioxygenase activity
HT135_04435	COG1917	Cupin 2, conserved barrel domain protein
HT135_04435	COG4977	sequence-specific DNA binding
HT135_04440	COG2814	Major facilitator Superfamily
HT135_04445	COG1082	Xylose isomerase domain protein TIM barrel
HT135_04450	COG0673	inositol 2-dehydrogenase activity
HT135_04455	COG4585	Histidine kinase
HT135_04460	COG2197	response regulator
HT135_04465	COG1131	(ABC) transporter
HT135_04470	COG0842	Transport permease protein
HT135_04470	COG1511	domain protein
HT135_04475	COG0842	Transport permease protein
HT135_04480	COG1695	Transcriptional regulator
HT135_04485	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HT135_04490	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HT135_04495	COG2318	DinB family
HT135_04500	COG2814	Major facilitator Superfamily
HT135_04505	COG1846	Transcriptional regulator
HT135_04510	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HT135_04510	COG0392	lysyltransferase activity
HT135_04515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HT135_04520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HT135_04525	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HT135_04530	COG0384	phenazine biosynthesis protein PhzF
HT135_04535	COG0778	Nitroreductase
HT135_04550	COG1090	epimerase
HT135_04555	COG2137	regulation of response to DNA damage stimulus
HT135_04565	COG2814	Major facilitator Superfamily
HT135_04580	COG1476	TRANSCRIPTIONal
HT135_04585	COG3103	Sh3 type 3 domain protein
HT135_04590	COG5658	integral membrane protein
HT135_04595	COG0596	Alpha beta hydrolase
HT135_04600	COG0463	Glycosyl transferase, family 2
HT135_04605	COG4485	Bacterial membrane protein, YfhO
HT135_04610	COG1988	membrane-bound metal-dependent
HT135_04615	COG1194	a g-specific adenine glycosylase
HT135_04625	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_04640	COG3557	Belongs to the UPF0374 family
HT135_04645	COG1132	(ABC) transporter
HT135_04650	COG4129	membrane
HT135_04655	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HT135_04660	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HT135_04665	COG0735	belongs to the Fur family
HT135_04775	COG4326	sporulation control protein
HT135_04785	COG1063	alcohol dehydrogenase
HT135_04790	COG5577	PFAM Coat F domain
HT135_04805	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HT135_04815	COG0753	catalase activity
HT135_04820	COG1116	anion transmembrane transporter activity
HT135_04825	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HT135_04830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HT135_04835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HT135_04845	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HT135_04855	COG1476	TRANSCRIPTIONal
HT135_04865	COG3382	B3 4 domain protein
HT135_04870	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HT135_04880	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HT135_04885	COG0789	Transcriptional regulator
HT135_04890	COG1664	Polymer-forming cytoskeletal
HT135_04900	COG2766	serine protein kinase
HT135_04905	COG2718	Belongs to the UPF0229 family
HT135_04910	COG1846	Transcriptional regulator
HT135_04915	COG1566	PFAM secretion protein HlyD family protein
HT135_04920	COG2814	Major facilitator Superfamily
HT135_04925	COG0655	NAD(P)H dehydrogenase (quinone) activity
HT135_04940	COG1725	Transcriptional regulator
HT135_04945	COG1131	(ABC) transporter
HT135_04950	COG1131	(ABC) transporter
HT135_04955	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HT135_04960	COG1278	Cold shock
HT135_04965	COG1464	Belongs to the NlpA lipoprotein family
HT135_04970	COG3706	GGDEF domain
HT135_04975	COG1823	symporter activity
HT135_04995	COG5577	PFAM Coat F domain
HT135_05000	COG0737	Belongs to the 5'-nucleotidase family
HT135_05000	COG4085	toxin activity
HT135_05000	COG1525	nuclease
HT135_05005	COG3764	Sortase (surface protein transpeptidase)
HT135_05010	COG0564	pseudouridine synthase activity
HT135_05020	COG0517	IMP dehydrogenase activity
HT135_05025	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HT135_05030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HT135_05030	COG3153	acetyltransferase
HT135_05040	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HT135_05045	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HT135_05050	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HT135_05055	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HT135_05060	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HT135_05065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HT135_05070	COG2203	Gaf domain
HT135_05070	COG4585	Histidine kinase
HT135_05075	COG2197	response regulator
HT135_05080	COG0431	NADPH-dependent FMN reductase
HT135_05095	COG0791	NLP P60 protein
HT135_05095	COG1388	LysM domain
HT135_05100	COG1959	2 iron, 2 sulfur cluster binding
HT135_05105	COG0668	transmembrane transport
HT135_05110	COG2719	SpoVR family
HT135_05115	COG1785	Belongs to the alkaline phosphatase family
HT135_05120	COG0791	NLP P60 protein
HT135_05120	COG1388	LysM domain
HT135_05125	COG0583	DNA-binding transcription factor activity
HT135_05130	COG0372	Belongs to the citrate synthase family
HT135_05135	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_05140	COG0531	amino acid
HT135_05145	COG0733	neurotransmitter:sodium symporter activity
HT135_05150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HT135_05155	COG0456	acetyltransferase
HT135_05170	COG1595	DNA-templated transcription, initiation
HT135_05175	COG0667	Aldo Keto reductase
HT135_05180	COG0204	Acyl-transferase
HT135_05185	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HT135_05190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HT135_05195	COG1253	flavin adenine dinucleotide binding
HT135_05200	COG0789	Transcriptional regulator
HT135_05205	COG0436	Aminotransferase
HT135_05210	COG1253	flavin adenine dinucleotide binding
HT135_05215	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HT135_05220	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HT135_05225	COG0584	glycerophosphoryl diester phosphodiesterase
HT135_05235	COG0668	transmembrane transport
HT135_05240	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HT135_05245	COG0726	polysaccharide deacetylase
HT135_05250	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HT135_05260	COG1757	Na H antiporter
HT135_05265	COG0589	response to stress
HT135_05270	COG1132	(ABC) transporter
HT135_05275	COG1132	(ABC) transporter
HT135_05280	COG0702	epimerase
HT135_05300	COG0189	ligase activity
HT135_05305	COG0189	ligase activity
HT135_05310	COG4399	Belongs to the UPF0754 family
HT135_05315	COG3679	Belongs to the UPF0342 family
HT135_05320	COG4335	DNA alkylation repair
HT135_05325	COG0561	phosphatase activity
HT135_05330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HT135_05335	COG0475	glutathione-regulated potassium exporter activity
HT135_05340	COG0490	domain, Protein
HT135_05350	COG1024	Enoyl-CoA hydratase
HT135_05360	COG4152	abc transporter atp-binding protein
HT135_05365	COG1668	transmembrane transport
HT135_05370	COG0420	3'-5' exonuclease activity
HT135_05375	COG4717	serine-type aminopeptidase activity
HT135_05380	COG3481	metal-dependent phosphohydrolase, HD sub domain
HT135_05390	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HT135_05420	COG1846	Transcriptional regulator
HT135_05425	COG4980	gas vesicle protein
HT135_05440	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HT135_05445	COG0537	adenosine 5'-monophosphoramidase activity
HT135_05450	COG1131	(ABC) transporter
HT135_05455	COG4473	ABC transporter
HT135_05465	COG1473	amidohydrolase
HT135_05470	COG3069	C4-dicarboxylate transmembrane transporter activity
HT135_05480	COG2329	Antibiotic biosynthesis monooxygenase
HT135_05485	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HT135_05490	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HT135_05505	COG1309	transcriptional regulator
HT135_05510	COG1511	domain protein
HT135_05515	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HT135_05520	COG4377	Putative membrane peptidase family (DUF2324)
HT135_05525	COG1363	Peptidase, m42
HT135_05530	COG4405	Protein conserved in bacteria
HT135_05535	COG1301	dicarboxylic acid transport
HT135_05545	COG1234	tRNA 3'-trailer cleavage
HT135_05550	COG0095	Lipoate-protein ligase
HT135_05555	COG0702	epimerase
HT135_05560	COG0318	PFAM AMP-dependent synthetase and ligase
HT135_05570	COG0501	Belongs to the peptidase M48B family
HT135_05575	COG1404	Belongs to the peptidase S8 family
HT135_05580	COG0456	acetyltransferase
HT135_05585	COG0604	alcohol dehydrogenase
HT135_05590	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HT135_05595	COG0406	alpha-ribazole phosphatase activity
HT135_05600	COG0183	Belongs to the thiolase family
HT135_05605	COG0318	PFAM AMP-dependent synthetase and ligase
HT135_05610	COG1268	BioY protein
HT135_05615	COG0840	transmembrane signaling receptor activity
HT135_05620	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HT135_05620	COG0723	plastoquinol--plastocyanin reductase activity
HT135_05625	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_05635	COG4903	ComK protein
HT135_05645	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_05655	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HT135_05670	COG0398	Pfam SNARE associated Golgi protein
HT135_05675	COG0681	Belongs to the peptidase S26 family
HT135_05680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HT135_05685	COG1846	Transcriptional regulator
HT135_05695	COG0738	Major facilitator superfamily
HT135_05700	COG0673	inositol 2-dehydrogenase activity
HT135_05705	COG0561	phosphatase activity
HT135_05710	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HT135_05715	COG1609	Transcriptional regulator
HT135_05720	COG3180	Ammonia monooxygenase
HT135_05725	COG2814	Major facilitator Superfamily
HT135_05725	COG0477	Major facilitator Superfamily
HT135_05730	COG4533	DNA binding
HT135_05740	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HT135_05745	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HT135_05750	COG1074	ATP-dependent DNA helicase activity
HT135_05755	COG0420	3'-5' exonuclease activity
HT135_05760	COG0419	ATPase involved in DNA repair
HT135_05765	COG1403	HNH endonuclease
HT135_05805	COG5337	Spore coat protein CotH
HT135_05810	COG0179	Fumarylacetoacetate (FAA) hydrolase
HT135_05820	COG1404	Belongs to the peptidase S8 family
HT135_05830	COG0367	asparagine synthase
HT135_05835	COG2318	DinB family
HT135_05840	COG1562	ergosterol biosynthetic process
HT135_05845	COG0534	Mate efflux family protein
HT135_05850	COG1917	Cupin 2, conserved barrel domain protein
HT135_05850	COG2207	Transcriptional regulator
HT135_05855	COG1609	Transcriptional regulator
HT135_05860	COG0673	inositol 2-dehydrogenase activity
HT135_05865	COG2318	DinB family
HT135_05870	COG1279	arginine transmembrane transporter activity
HT135_05875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HT135_05880	COG1357	PFAM Pentapeptide repeats (8 copies)
HT135_05885	COG2267	carboxylic ester hydrolase activity
HT135_05890	COG0529	Catalyzes the synthesis of activated sulfate
HT135_05895	COG2046	Belongs to the sulfate adenylyltransferase family
HT135_05900	COG0175	sulfate reduction
HT135_05905	COG2045	Belongs to the ComB family
HT135_05910	COG1809	phosphosulfolactate synthase activity
HT135_05915	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HT135_05920	COG4948	Mandelate Racemase Muconate Lactonizing
HT135_05925	COG2814	Major facilitator Superfamily
HT135_05930	COG0454	-acetyltransferase
HT135_05935	COG2153	protein acetylation
HT135_05940	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HT135_05940	COG0646	methionine synthase
HT135_05945	COG1666	GTP binding
HT135_05950	COG2996	Protein conserved in bacteria
HT135_05970	COG1695	Transcriptional regulator
HT135_05985	COG3227	Zinc metalloprotease (Elastase)
HT135_05990	COG1307	EDD domain protein, DegV family
HT135_05995	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HT135_06015	COG0561	phosphatase activity
HT135_06020	COG1073	alpha beta
HT135_06025	COG2151	metal-sulfur cluster biosynthetic enzyme
HT135_06035	COG0277	FAD linked oxidase domain protein
HT135_06040	COG2271	Major facilitator Superfamily
HT135_06045	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HT135_06050	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HT135_06060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HT135_06065	COG0505	Belongs to the CarA family
HT135_06070	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HT135_06075	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HT135_06090	COG2267	carboxylic ester hydrolase activity
HT135_06100	COG1744	ABC transporter substrate-binding protein PnrA-like
HT135_06115	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HT135_06120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HT135_06125	COG5504	Zn-dependent protease
HT135_06130	COG0444	Belongs to the ABC transporter superfamily
HT135_06135	COG4608	Belongs to the ABC transporter superfamily
HT135_06145	COG0601	transmembrane transport
HT135_06150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HT135_06160	COG0180	Tryptophanyl-tRNA synthetase
HT135_06165	COG4166	transmembrane transport
HT135_06170	COG0601	transmembrane transport
HT135_06175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HT135_06180	COG0444	Belongs to the ABC transporter superfamily
HT135_06185	COG4608	Belongs to the ABC transporter superfamily
HT135_06190	COG2814	Major facilitator Superfamily
HT135_06195	COG0456	acetyltransferase
HT135_06200	COG1393	Belongs to the ArsC family
HT135_06205	COG0861	Integral membrane protein TerC family
HT135_06215	COG4862	establishment of competence for transformation
HT135_06220	COG4469	Competence protein
HT135_06225	COG1164	Oligoendopeptidase f
HT135_06240	COG2346	COG2346, Truncated hemoglobins
HT135_06245	COG0741	lytic transglycosylase activity
HT135_06250	COG4116	CYTH
HT135_06260	COG2357	RelA SpoT domain protein
HT135_06265	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HT135_06270	COG0564	pseudouridine synthase activity
HT135_06275	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HT135_06280	COG0475	glutathione-regulated potassium exporter activity
HT135_06280	COG0569	domain protein
HT135_06285	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HT135_06290	COG0352	thiamine-phosphate diphosphorylase activity
HT135_06295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HT135_06300	COG2104	thiamine diphosphate biosynthetic process
HT135_06305	COG2022	thiamine diphosphate biosynthetic process
HT135_06310	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HT135_06315	COG0351	phosphomethylpyrimidine kinase
HT135_06320	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HT135_06375	COG0210	DNA helicase
HT135_06385	COG2153	protein acetylation
HT135_06390	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HT135_06395	COG2382	esterase
HT135_06400	COG0626	cystathionine gamma-synthase activity
HT135_06405	COG0626	cystathionine gamma-synthase activity
HT135_06410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HT135_06415	COG5505	Protein of unknown function (DUF819)
HT135_06425	COG0582	viral genome integration into host DNA
HT135_06440	COG3646	Phage regulatory protein
HT135_06440	COG3645	SOS response
HT135_06560	COG3953	SLT domain
HT135_06560	COG5280	Phage tail tape measure protein TP901
HT135_06595	COG4824	toxin secretion phage lysis holin
HT135_06600	COG3409	Peptidoglycan-binding domain 1 protein
HT135_06600	COG5632	N-Acetylmuramoyl-L-alanine amidase
HT135_06660	COG5444	nuclease activity
HT135_06675	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HT135_06705	COG3409	Peptidoglycan-binding domain 1 protein
HT135_06725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HT135_06730	COG0583	DNA-binding transcription factor activity
HT135_06735	COG0697	spore germination
HT135_06745	COG0789	Transcriptional regulator
HT135_06765	COG0109	protoheme IX farnesyltransferase activity
HT135_06775	COG0726	polysaccharide deacetylase
HT135_06790	COG5504	Zn-dependent protease
HT135_06795	COG2205	protein histidine kinase activity
HT135_06805	COG3383	formate dehydrogenase (NAD+) activity
HT135_06810	COG2427	Protein of unknown function (DUF1641)
HT135_06820	COG1051	belongs to the nudix hydrolase family
HT135_06830	COG2124	cytochrome p450
HT135_06835	COG1819	glycosyl
HT135_06850	COG1587	Uroporphyrinogen-III synthase
HT135_06855	COG0390	transport system, permease component
HT135_06860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HT135_06865	COG0697	spore germination
HT135_06870	COG4297	protein containing double-stranded beta helix domain
HT135_06880	COG1252	NADH dehydrogenase
HT135_06885	COG1904	glucuronate isomerase
HT135_06890	COG2211	Major facilitator Superfamily
HT135_06895	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HT135_06900	COG1063	alcohol dehydrogenase
HT135_06905	COG1312	Catalyzes the dehydration of D-mannonate
HT135_06910	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_06915	COG2271	Major facilitator Superfamily
HT135_06920	COG1609	Transcriptional regulator
HT135_06925	COG0246	Mannitol dehydrogenase
HT135_06930	COG2721	sulfolactate sulfo-lyase activity
HT135_06935	COG0730	response to heat
HT135_06940	COG2318	DinB family
HT135_06945	COG0457	Tetratricopeptide repeat
HT135_06955	COG2350	Protein conserved in bacteria
HT135_06960	COG3409	Peptidoglycan-binding domain 1 protein
HT135_06960	COG1388	LysM domain
HT135_06960	COG5632	N-Acetylmuramoyl-L-alanine amidase
HT135_06970	COG4195	phage-related replication protein
HT135_06975	COG3546	catalase activity
HT135_06980	COG2856	Zn peptidase
HT135_06985	COG1396	sequence-specific DNA binding
HT135_06995	COG1522	sequence-specific DNA binding
HT135_07000	COG1484	DNA-dependent DNA replication
HT135_07020	COG1595	DNA-templated transcription, initiation
HT135_07025	COG5484	DNA packaging
HT135_07025	COG3728	DNA packaging
HT135_07030	COG1783	phage Terminase large subunit
HT135_07035	COG5518	Phage portal protein
HT135_07040	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HT135_07045	COG4653	Phage capsid family
HT135_07095	COG5412	phage tail tape measure protein
HT135_07095	COG3953	SLT domain
HT135_07100	COG1652	LysM domain
HT135_07105	COG4193	domain, Protein
HT135_07115	COG3628	GPW Gp25 family protein
HT135_07120	COG3299	homolog of phage Mu protein gp47
HT135_07125	COG3778	Protein conserved in bacteria
HT135_07165	COG5632	N-Acetylmuramoyl-L-alanine amidase
HT135_07165	COG3409	Peptidoglycan-binding domain 1 protein
HT135_07185	COG0306	phosphate transporter
HT135_07190	COG1392	Phosphate transport regulator
HT135_07195	COG0531	amino acid
HT135_07200	COG0346	lactoylglutathione lyase activity
HT135_07205	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HT135_07210	COG0463	Glycosyl transferase, family 2
HT135_07220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HT135_07225	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HT135_07230	COG2362	D-Aminopeptidase
HT135_07235	COG0601	transmembrane transport
HT135_07240	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HT135_07245	COG0444	Belongs to the ABC transporter superfamily
HT135_07250	COG4166	transmembrane transport
HT135_07255	COG1619	proteins homologs of microcin C7 resistance protein MccF
HT135_07260	COG4948	Mandelate Racemase Muconate Lactonizing
HT135_07265	COG0791	NLP P60 protein
HT135_07270	COG4608	Belongs to the ABC transporter superfamily
HT135_07275	COG2706	6-phosphogluconolactonase activity
HT135_07280	COG1834	amidinotransferase
HT135_07285	COG1607	acyl-coa hydrolase
HT135_07290	COG1017	nitric oxide dioxygenase activity
HT135_07290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HT135_07300	COG2323	membrane
HT135_07305	COG2318	DinB family
HT135_07310	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HT135_07315	COG2076	Multidrug Resistance protein
HT135_07320	COG2076	Multidrug Resistance protein
HT135_07325	COG0788	formyltetrahydrofolate deformylase activity
HT135_07330	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HT135_07335	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HT135_07340	COG1764	response to oxidative stress
HT135_07345	COG1846	Transcriptional regulator
HT135_07350	COG1764	response to oxidative stress
HT135_07355	COG0457	Tetratricopeptide repeat
HT135_07355	COG0463	Glycosyl transferase, family 2
HT135_07360	COG0590	tRNA wobble adenosine to inosine editing
HT135_07365	COG0406	alpha-ribazole phosphatase activity
HT135_07370	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HT135_07375	COG1404	Belongs to the peptidase S8 family
HT135_07380	COG1366	Belongs to the anti-sigma-factor antagonist family
HT135_07385	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HT135_07390	COG1122	ATPase activity
HT135_07395	COG4721	ABC-type cobalt transport system, permease component
HT135_07405	COG0745	RESPONSE REGULATOR receiver
HT135_07410	COG5002	protein histidine kinase activity
HT135_07410	COG3850	Histidine kinase
HT135_07415	COG3212	peptidase
HT135_07420	COG3212	peptidase
HT135_07430	COG2239	Acts as a magnesium transporter
HT135_07435	COG0789	Transcriptional regulator
HT135_07450	COG1846	Transcriptional regulator
HT135_07455	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HT135_07460	COG0726	polysaccharide deacetylase
HT135_07465	COG1408	metallophosphoesterase
HT135_07475	COG0463	Glycosyl transferase, family 2
HT135_07480	COG3285	dna ligase
HT135_07480	COG1793	dna ligase
HT135_07485	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HT135_07490	COG3300	MHYT domain
HT135_07490	COG5001	Diguanylate cyclase
HT135_07495	COG0586	Pfam SNARE associated Golgi protein
HT135_07500	COG0861	Integral membrane protein TerC family
HT135_07505	COG1191	sigma factor activity
HT135_07525	COG0501	Belongs to the peptidase M48B family
HT135_07530	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HT135_07545	COG3594	Acyltransferase
HT135_07550	COG5002	protein histidine kinase activity
HT135_07555	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HT135_07565	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HT135_07570	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HT135_07575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HT135_07580	COG0436	Aminotransferase
HT135_07585	COG1850	ribulose-bisphosphate carboxylase activity
HT135_07590	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HT135_07595	COG0235	Class ii aldolase
HT135_07600	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HT135_07605	COG3339	Conserved Protein
HT135_07620	COG3852	Histidine kinase
HT135_07625	COG1846	Transcriptional regulator
HT135_07630	COG1360	Flagellar Motor Protein
HT135_07635	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HT135_07640	COG0542	response to heat
HT135_07645	COG3949	Membrane
HT135_07650	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HT135_07655	COG0720	synthase
HT135_07660	COG0602	queuosine metabolic process
HT135_07665	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HT135_07670	COG4641	Protein conserved in bacteria
HT135_07670	COG1388	LysM domain
HT135_07675	COG1388	LysM domain
HT135_07680	COG3858	chitin binding
HT135_07690	COG4873	Protein conserved in bacteria
HT135_07700	COG3773	Cell wall hydrolase
HT135_07705	COG2244	polysaccharide biosynthetic process
HT135_07710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HT135_07715	COG2217	Heavy metal translocating P-type atpase
HT135_07725	COG0006	proline dipeptidase activity
HT135_07730	COG1609	Transcriptional regulator
HT135_07735	COG3711	transcriptional antiterminator
HT135_07740	COG2190	(PTS) system
HT135_07740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT135_07740	COG1263	PTS System
HT135_07745	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT135_07750	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HT135_07760	COG1533	DNA photolyase activity
HT135_07770	COG0840	transmembrane signaling receptor activity
HT135_07775	COG2084	Dehydrogenase
HT135_07780	COG2340	Cysteine-rich secretory protein family
HT135_07785	COG0768	penicillin binding
HT135_07790	COG4191	Histidine kinase
HT135_07795	COG0436	Aminotransferase
HT135_07805	COG0784	Response regulator, receiver
HT135_07805	COG0835	chemotaxis
HT135_07815	COG2814	Major facilitator Superfamily
HT135_07820	COG1376	ErfK ybiS ycfS ynhG family protein
HT135_07825	COG1408	metallophosphoesterase
HT135_07830	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_07835	COG2200	EAL domain
HT135_07840	COG3546	catalase activity
HT135_07845	COG4703	Protein of unknown function (DUF1797)
HT135_07850	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HT135_07860	COG0517	IMP dehydrogenase activity
HT135_07865	COG0583	DNA-binding transcription factor activity
HT135_07870	COG0716	FMN binding
HT135_07880	COG0716	FMN binding
HT135_07885	COG2171	N-acyltransferase activity
HT135_07890	COG1473	amidohydrolase
HT135_07900	COG0668	transmembrane transport
HT135_07905	COG0450	alkyl hydroperoxide reductase
HT135_07910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HT135_07925	COG0746	molybdenum cofactor guanylyltransferase activity
HT135_07930	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HT135_07935	COG0303	'Molybdopterin
HT135_07940	COG1763	Mo-molybdopterin cofactor biosynthetic process
HT135_07945	COG0314	molybdopterin synthase activity
HT135_07950	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HT135_07955	COG1132	(ABC) transporter
HT135_07960	COG1132	(ABC) transporter
HT135_07970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HT135_07975	COG1136	(ABC) transporter
HT135_07980	COG0577	efflux transmembrane transporter activity
HT135_07985	COG1349	DNA-binding transcription factor activity
HT135_07990	COG1105	Belongs to the carbohydrate kinase PfkB family
HT135_07995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT135_07995	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HT135_07995	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HT135_08000	COG0681	Belongs to the peptidase S26 family
HT135_08010	COG0488	(ABC) transporter
HT135_08015	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HT135_08020	COG2309	aminopeptidase activity
HT135_08030	COG1077	Cell shape determining protein MreB Mrl
HT135_08035	COG2002	toxin-antitoxin pair type II binding
HT135_08040	COG3852	Histidine kinase
HT135_08045	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HT135_08045	COG2105	PFAM AIG2 family protein
HT135_08050	COG0569	domain protein
HT135_08055	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HT135_08060	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HT135_08070	COG0561	phosphatase activity
HT135_08075	COG0242	peptide deformylase activity
HT135_08085	COG0497	DNA recombination
HT135_08090	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HT135_08095	COG0022	dehydrogenase e1 component
HT135_08100	COG0508	dehydrogenase complex catalyzes the overall conversion of
HT135_08105	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HT135_08110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HT135_08120	COG1982	Orn Lys Arg decarboxylase major
HT135_08125	COG4476	Belongs to the UPF0223 family
HT135_08130	COG4493	Belongs to the UPF0637 family
HT135_08140	COG0483	inositol monophosphate 1-phosphatase activity
HT135_08150	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HT135_08200	COG4896	Protein conserved in bacteria
HT135_08210	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HT135_08215	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HT135_08220	COG2066	Belongs to the glutaminase family
HT135_08225	COG4838	Belongs to the UPF0358 family
HT135_08230	COG0772	Belongs to the SEDS family
HT135_08235	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HT135_08240	COG1612	heme a metabolic process
HT135_08245	COG0109	protoheme IX farnesyltransferase activity
HT135_08250	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HT135_08250	COG2010	Cytochrome c
HT135_08255	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HT135_08260	COG1845	cytochrome c oxidase, subunit III
HT135_08265	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HT135_08270	COG3336	cytochrome c oxidase
HT135_08280	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HT135_08285	COG2340	Cysteine-rich secretory protein family
HT135_08300	COG3679	Belongs to the UPF0342 family
HT135_08305	COG4471	UPF0298 protein
HT135_08310	COG0742	ribosomal rna small subunit methyltransferase
HT135_08315	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HT135_08320	COG3314	Sporulation integral membrane protein YlbJ
HT135_08325	COG1752	Esterase of the alpha-beta hydrolase superfamily
HT135_08330	COG3480	Lon protease (S16) C-terminal proteolytic domain
HT135_08340	COG1323	Belongs to the UPF0348 family
HT135_08345	COG1399	metal-binding, possibly nucleic acid-binding protein
HT135_08360	COG0454	-acetyltransferase
HT135_08365	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HT135_08370	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HT135_08375	COG2001	Belongs to the MraZ family
HT135_08380	COG0275	rRNA processing
HT135_08385	COG4839	cell division protein FtsL
HT135_08395	COG0768	penicillin binding
HT135_08400	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HT135_08405	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HT135_08410	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HT135_08415	COG0772	Belongs to the SEDS family
HT135_08420	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HT135_08425	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HT135_08430	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HT135_08435	COG3879	Bacterial protein of unknown function (DUF881)
HT135_08440	COG3879	Bacterial protein of unknown function (DUF881)
HT135_08445	COG3856	small basic protein
HT135_08450	COG0849	cell division
HT135_08455	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HT135_08460	COG1404	Belongs to the peptidase S8 family
HT135_08460	COG4412	M6 family metalloprotease domain protein
HT135_08470	COG1191	sigma factor activity
HT135_08475	COG1191	sigma factor activity
HT135_08480	COG1119	ATPase activity
HT135_08485	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HT135_08490	COG1873	PFAM PRC-barrel domain
HT135_08500	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HT135_08505	COG1799	cell septum assembly
HT135_08510	COG0762	integral membrane protein
HT135_08515	COG2302	S4 RNA-binding domain
HT135_08520	COG3599	regulation of cell shape
HT135_08525	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HT135_08530	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HT135_08535	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HT135_08540	COG0564	pseudouridine synthase activity
HT135_08545	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HT135_08550	COG2233	PERMEase
HT135_08555	COG0540	Belongs to the ATCase OTCase family
HT135_08560	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HT135_08565	COG0505	Belongs to the CarA family
HT135_08570	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HT135_08575	COG0543	2 iron, 2 sulfur cluster binding
HT135_08580	COG0167	dihydroorotate dehydrogenase activity
HT135_08585	COG0284	orotidine-5'-phosphate decarboxylase activity
HT135_08590	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HT135_08595	COG0175	sulfate reduction
HT135_08600	COG0306	phosphate transporter
HT135_08605	COG2046	Belongs to the sulfate adenylyltransferase family
HT135_08610	COG0529	Catalyzes the synthesis of activated sulfate
HT135_08615	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HT135_08620	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HT135_08625	COG1648	precorrin-2 dehydrogenase activity
HT135_08630	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HT135_08635	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HT135_08640	COG1561	YicC-like family, N-terminal region
HT135_08650	COG0194	GDP metabolic process
HT135_08655	COG1758	RNA polymerase activity
HT135_08660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HT135_08665	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HT135_08670	COG0242	peptide deformylase activity
HT135_08675	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HT135_08680	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HT135_08680	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HT135_08685	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HT135_08690	COG0631	protein serine/threonine phosphatase activity
HT135_08695	COG0515	serine threonine protein kinase
HT135_08695	COG2815	serine threonine protein kinase
HT135_08700	COG1162	GTPase activity
HT135_08705	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HT135_08710	COG1564	THIamine pyrophosphokinase
HT135_08720	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HT135_08725	COG1302	Protein conserved in bacteria
HT135_08730	COG1461	Dihydroxyacetone kinase
HT135_08735	COG1760	l-serine dehydratase
HT135_08740	COG1760	l-serine dehydratase
HT135_08745	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HT135_08750	COG1349	DNA-binding transcription factor activity
HT135_08750	COG2050	protein possibly involved in aromatic compounds catabolism
HT135_08755	COG0416	fatty acid biosynthetic process
HT135_08760	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HT135_08765	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_08775	COG0571	ribonuclease III activity
HT135_08780	COG1196	nuclear chromosome segregation
HT135_08785	COG0552	protein localization to endoplasmic reticulum
HT135_08795	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HT135_08800	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HT135_08805	COG0228	four-way junction DNA binding
HT135_08810	COG1837	Belongs to the UPF0109 family
HT135_08820	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HT135_08825	COG0336	Belongs to the RNA methyltransferase TrmD family
HT135_08830	COG0335	large ribosomal subunit rRNA binding
HT135_08835	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HT135_08840	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HT135_08850	COG2257	FlhB HrpN YscU SpaS Family
HT135_08855	COG0045	succinate-CoA ligase (ADP-forming) activity
HT135_08860	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HT135_08865	COG0758	DNA mediated transformation
HT135_08870	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HT135_08875	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HT135_08880	COG4974	Belongs to the 'phage' integrase family
HT135_08885	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HT135_08890	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HT135_08895	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HT135_08900	COG1815	bacterial-type flagellum-dependent cell motility
HT135_08905	COG1558	bacterial-type flagellum-dependent cell motility
HT135_08910	COG1677	Flagellar hook-basal body complex protein FliE
HT135_08915	COG1766	The M ring may be actively involved in energy transduction
HT135_08920	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HT135_08925	COG1317	bacterial-type flagellum organization
HT135_08930	COG1157	protein secretion by the type III secretion system
HT135_08935	COG2882	bacterial-type flagellum organization
HT135_08940	COG3334	PFAM MgtE intracellular
HT135_08945	COG3144	bacterial-type flagellum assembly
HT135_08950	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HT135_08955	COG4786	Flagellar basal body rod
HT135_08960	COG1582	Flagellar protein (FlbD)
HT135_08965	COG1580	Controls the rotational direction of flagella during chemotaxis
HT135_08970	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HT135_08975	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HT135_08975	COG1776	CheC inhibitor of MCP methylation
HT135_08980	COG2201	protein-glutamate methylesterase activity
HT135_08985	COG3190	flagellar
HT135_08990	COG1338	Plays a role in the flagellum-specific transport system
HT135_08995	COG1987	bacterial-type flagellum assembly
HT135_09000	COG1684	flagellar biosynthetic protein fliR
HT135_09005	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HT135_09010	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HT135_09015	COG1419	protein localization to endoplasmic reticulum
HT135_09020	COG0455	bacterial-type flagellum organization
HT135_09025	COG2201	protein-glutamate methylesterase activity
HT135_09030	COG0643	Histidine kinase
HT135_09030	COG2198	Histidine kinase
HT135_09035	COG0835	chemotaxis
HT135_09040	COG1776	CheC inhibitor of MCP methylation
HT135_09045	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HT135_09050	COG1191	sigma factor activity
HT135_09060	COG0052	Belongs to the universal ribosomal protein uS2 family
HT135_09065	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HT135_09070	COG0528	UMP kinase activity
HT135_09075	COG0233	cytoplasmic translational termination
HT135_09080	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HT135_09085	COG4589	Belongs to the CDS family
HT135_09090	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HT135_09095	COG0750	zinc metalloprotease
HT135_09100	COG0442	prolyl-tRNA aminoacylation
HT135_09105	COG2176	DNA-directed DNA polymerase activity
HT135_09110	COG0779	Required for maturation of 30S ribosomal subunits
HT135_09115	COG0195	Participates in both transcription termination and antitermination
HT135_09120	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HT135_09125	COG1358	cellular component organization or biogenesis
HT135_09130	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HT135_09135	COG1550	Protein conserved in bacteria
HT135_09140	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HT135_09145	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HT135_09150	COG0196	riboflavin kinase activity
HT135_09160	COG1185	polyribonucleotide nucleotidyltransferase activity
HT135_09165	COG0726	polysaccharide deacetylase
HT135_09170	COG0612	Peptidase, M16
HT135_09175	COG1873	PFAM PRC-barrel domain
HT135_09180	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HT135_09185	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HT135_09190	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HT135_09195	COG0527	aspartate kinase activity
HT135_09200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HT135_09205	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HT135_09210	COG0740	serine-type endopeptidase activity
HT135_09220	COG1674	ftsk spoiiie
HT135_09220	COG4980	gas vesicle protein
HT135_09225	COG2188	Transcriptional regulator
HT135_09230	COG2814	Major facilitator Superfamily
HT135_09235	COG0612	Peptidase, M16
HT135_09240	COG0612	Peptidase, M16
HT135_09245	COG0300	oxidoreductase activity
HT135_09260	COG1426	Protein conserved in bacteria
HT135_09265	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HT135_09270	COG1058	Belongs to the CinA family
HT135_09270	COG1546	Belongs to the CinA family
HT135_09275	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HT135_09280	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HT135_09285	COG1418	mRNA catabolic process
HT135_09290	COG1692	metallophosphoesterase
HT135_09295	COG2359	stage V sporulation protein S
HT135_09300	COG1063	alcohol dehydrogenase
HT135_09305	COG0156	8-amino-7-oxononanoate synthase activity
HT135_09310	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HT135_09315	COG4550	Control of competence regulator ComK, YlbF/YmcA
HT135_09325	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HT135_09330	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HT135_09365	COG4195	phage-related replication protein
HT135_09375	COG0582	viral genome integration into host DNA
HT135_09400	COG3226	Transcriptional regulator
HT135_09405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HT135_09410	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HT135_09415	COG3321	synthase
HT135_09420	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HT135_09420	COG2070	2-Nitropropane dioxygenase
HT135_09425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HT135_09430	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HT135_09435	COG3425	synthase
HT135_09440	COG1024	Enoyl-CoA hydratase
HT135_09445	COG1024	Enoyl-CoA hydratase
HT135_09450	COG3321	synthase
HT135_09450	COG0300	oxidoreductase activity
HT135_09450	COG0318	PFAM AMP-dependent synthetase and ligase
HT135_09450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_09450	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_09455	COG4221	oxidoreductase activity
HT135_09455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HT135_09455	COG0300	oxidoreductase activity
HT135_09455	COG3321	synthase
HT135_09460	COG3321	synthase
HT135_09460	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_09460	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_09460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HT135_09460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HT135_09465	COG4221	oxidoreductase activity
HT135_09465	COG3321	synthase
HT135_09465	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_09465	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_09470	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HT135_09470	COG3321	synthase
HT135_09470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HT135_09470	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HT135_09475	COG2124	cytochrome p450
HT135_09485	COG1404	Belongs to the peptidase S8 family
HT135_09490	COG4195	phage-related replication protein
HT135_09495	COG1764	response to oxidative stress
HT135_09520	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HT135_09525	COG1923	regulation of RNA biosynthetic process
HT135_09545	COG1780	Probably involved in ribonucleotide reductase function
HT135_09550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HT135_09555	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HT135_09560	COG4112	unkown
HT135_09565	COG0860	N-Acetylmuramoyl-L-alanine amidase
HT135_09570	COG0464	growth
HT135_09575	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HT135_09580	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HT135_09585	COG0789	Transcriptional regulator
HT135_09590	COG0174	glutamine synthetase
HT135_09595	COG3409	Peptidoglycan-binding domain 1 protein
HT135_09595	COG5632	N-Acetylmuramoyl-L-alanine amidase
HT135_09595	COG1388	LysM domain
HT135_09605	COG5444	nuclease activity
HT135_09610	COG0457	Tetratricopeptide repeat
HT135_09620	COG0456	acetyltransferase
HT135_09655	COG2273	Hydrolase Family 16
HT135_09665	COG0457	Tetratricopeptide repeat
HT135_09695	COG0726	polysaccharide deacetylase
HT135_09720	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HT135_09725	COG2720	vancomycin resistance protein
HT135_09730	COG3739	integral membrane protein
HT135_09735	COG3655	Transcriptional regulator
HT135_09745	COG2135	peptidase activity
HT135_09760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HT135_09770	COG3832	glyoxalase III activity
HT135_09800	COG4195	phage-related replication protein
HT135_09820	COG0346	lactoylglutathione lyase activity
HT135_09830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HT135_09835	COG1388	LysM domain
HT135_09840	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HT135_09845	COG4224	UPF0291 protein
HT135_09850	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HT135_09860	COG3763	UPF0154 protein
HT135_09870	COG0785	Cytochrome C biogenesis protein
HT135_09875	COG2201	protein-glutamate methylesterase activity
HT135_09880	COG4846	Membrane protein involved in cytochrome C biogenesis
HT135_09890	COG0071	Belongs to the small heat shock protein (HSP20) family
HT135_09905	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HT135_09910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HT135_09930	COG0824	Thioesterase
HT135_09940	COG4841	protein insertion into membrane
HT135_09945	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HT135_09950	COG1832	CoA-binding protein
HT135_09955	COG0187	DNA topoisomerase II activity
HT135_09960	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HT135_09970	COG1115	amino acid carrier protein
HT135_09975	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HT135_09990	COG5520	Belongs to the glycosyl hydrolase 30 family
HT135_09995	COG3507	Belongs to the glycosyl hydrolase 43 family
HT135_10000	COG2246	polysaccharide biosynthetic process
HT135_10010	COG0586	Pfam SNARE associated Golgi protein
HT135_10015	COG2404	hydrolase activity, acting on ester bonds
HT135_10020	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HT135_10025	COG1024	Enoyl-CoA hydratase
HT135_10030	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HT135_10035	COG0511	ligase activity, forming carbon-carbon bonds
HT135_10040	COG0439	Biotin carboxylase
HT135_10045	COG0318	PFAM AMP-dependent synthetase and ligase
HT135_10050	COG1960	acyl-CoA dehydrogenase activity
HT135_10060	COG1649	PFAM Uncharacterised BCR, COG1649
HT135_10070	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HT135_10070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_10075	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_10080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_10085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_10090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_10095	COG2027	D-alanyl-D-alanine carboxypeptidase
HT135_10100	COG2017	converts alpha-aldose to the beta-anomer
HT135_10105	COG0534	Mate efflux family protein
HT135_10120	COG0582	viral genome integration into host DNA
HT135_10125	COG0166	Belongs to the GPI family
HT135_10130	COG0405	Gamma-glutamyltransferase
HT135_10135	COG0583	DNA-binding transcription factor activity
HT135_10140	COG0604	alcohol dehydrogenase
HT135_10145	COG0493	'glutamate synthase
HT135_10150	COG0067	glutamate synthase
HT135_10150	COG0070	glutamate synthase
HT135_10150	COG0069	glutamate synthase activity
HT135_10155	COG0583	DNA-binding transcription factor activity
HT135_10160	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HT135_10180	COG0300	oxidoreductase activity
HT135_10185	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HT135_10195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HT135_10210	COG1131	(ABC) transporter
HT135_10220	COG2814	Major facilitator Superfamily
HT135_10225	COG1070	Carbohydrate kinase
HT135_10230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HT135_10235	COG0243	molybdopterin cofactor binding
HT135_10245	COG0673	inositol 2-dehydrogenase activity
HT135_10250	COG1082	Xylose isomerase domain protein TIM barrel
HT135_10255	COG1609	Transcriptional regulator
HT135_10260	COG4305	rare lipoprotein A
HT135_10265	COG3619	membrane
HT135_10275	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_10310	COG2814	Major facilitator Superfamily
HT135_10315	COG1525	nuclease
HT135_10320	COG1231	oxidoreductase activity
HT135_10330	COG1070	Carbohydrate kinase
HT135_10345	COG3507	Belongs to the glycosyl hydrolase 43 family
HT135_10350	COG2211	Major facilitator Superfamily
HT135_10365	COG3397	chitin binding
HT135_10370	COG2318	DinB family
HT135_10375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HT135_10455	COG0457	Tetratricopeptide repeat
HT135_10470	COG3848	Pyruvate phosphate dikinase
HT135_10470	COG0574	Belongs to the PEP-utilizing enzyme family
HT135_10490	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_10495	COG1733	regulation of RNA biosynthetic process
HT135_10505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HT135_10510	COG0662	Cupin 2, conserved barrel domain protein
HT135_10510	COG2207	Transcriptional regulator
HT135_10515	COG0456	acetyltransferase
HT135_10520	COG1309	transcriptional regulator
HT135_10525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HT135_10530	COG3708	Transcriptional regulator
HT135_10535	COG2378	regulation of single-species biofilm formation
HT135_10545	COG0640	Transcriptional regulator
HT135_10550	COG0741	lytic transglycosylase activity
HT135_10555	COG2322	membrane
HT135_10570	COG1619	proteins homologs of microcin C7 resistance protein MccF
HT135_10575	COG3239	Fatty acid desaturase
HT135_10580	COG4585	Histidine kinase
HT135_10585	COG2197	response regulator
HT135_10595	COG1388	LysM domain
HT135_10595	COG3584	3D domain protein
HT135_10600	COG0514	ATP-dependent DNA helicase (RecQ)
HT135_10610	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HT135_10615	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HT135_10630	COG1012	belongs to the aldehyde dehydrogenase family
HT135_10635	COG1657	PFAM Prenyltransferase squalene oxidase
HT135_10640	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HT135_10645	COG0733	neurotransmitter:sodium symporter activity
HT135_10650	COG0385	Bile acid
HT135_10655	COG0508	dehydrogenase complex catalyzes the overall conversion of
HT135_10660	COG0567	Dehydrogenase, E1 component
HT135_10665	COG4548	von Willebrand factor, type A
HT135_10670	COG0714	Associated with various cellular activities
HT135_10675	COG2032	superoxide dismutase activity
HT135_10680	COG0791	NLP P60 protein
HT135_10680	COG1388	LysM domain
HT135_10685	COG1819	glycosyl
HT135_10690	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HT135_10695	COG0534	Mate efflux family protein
HT135_10700	COG1366	Belongs to the anti-sigma-factor antagonist family
HT135_10705	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HT135_10710	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HT135_10720	COG2962	Rard protein
HT135_10740	COG1942	4-Oxalocrotonate Tautomerase
HT135_10750	COG1733	regulation of RNA biosynthetic process
HT135_10755	COG0778	Nitroreductase
HT135_10760	COG0400	carboxylic ester hydrolase activity
HT135_10765	COG0346	lactoylglutathione lyase activity
HT135_10775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HT135_10780	COG0793	Belongs to the peptidase S41A family
HT135_10780	COG3409	Peptidoglycan-binding domain 1 protein
HT135_10785	COG2226	methyltransferase
HT135_10795	COG1876	peptidase activity
HT135_10800	COG0813	purine-nucleoside phosphorylase activity
HT135_10815	COG0671	phosphoesterase, PA-phosphatase related
HT135_10835	COG4479	Belongs to the UPF0346 family
HT135_10845	COG1509	lysine 2,3-aminomutase activity
HT135_10850	COG0456	acetyltransferase
HT135_10855	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HT135_10860	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HT135_10865	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HT135_10870	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HT135_10880	COG0456	acetyltransferase
HT135_10885	COG0463	Glycosyl transferase, family 2
HT135_10900	COG4641	Protein conserved in bacteria
HT135_10905	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
HT135_10910	COG1086	Polysaccharide biosynthesis protein
HT135_10920	COG3331	DNA recombination
HT135_10985	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HT135_11005	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HT135_11010	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HT135_11035	COG0756	dUTP diphosphatase activity
HT135_11045	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HT135_11050	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HT135_11055	COG1372	Participates in initiation and elongation during chromosome replication
HT135_11055	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HT135_11065	COG1372	Participates in initiation and elongation during chromosome replication
HT135_11065	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HT135_11070	COG1780	Probably involved in ribonucleotide reductase function
HT135_11165	COG0270	DNA (cytosine-5-)-methyltransferase activity
HT135_11180	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HT135_11205	COG3584	3D domain protein
HT135_11210	COG0587	DNA-directed DNA polymerase activity
HT135_11215	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HT135_11220	COG0358	DNA primase activity
HT135_11225	COG0305	Participates in initiation and elongation during chromosome replication
HT135_11235	COG2887	Belongs to the helicase family. UvrD subfamily
HT135_11260	COG3420	alginic acid biosynthetic process
HT135_11260	COG5434	Belongs to the glycosyl hydrolase 28 family
HT135_11265	COG4195	phage-related replication protein
HT135_11285	COG2135	peptidase activity
HT135_11290	COG1793	dna ligase
HT135_11365	COG3655	Transcriptional regulator
HT135_11380	COG0582	viral genome integration into host DNA
HT135_11460	COG3655	Transcriptional regulator
HT135_11535	COG1395	domain, Protein
HT135_11550	COG0776	regulation of translation
HT135_11585	COG4373	Mu-like prophage FluMu protein gp28
HT135_11685	COG0582	viral genome integration into host DNA
HT135_11700	COG0739	heme binding
HT135_11700	COG0741	lytic transglycosylase activity
HT135_11700	COG1196	nuclear chromosome segregation
HT135_11710	COG2433	Pfam Transposase IS66
HT135_11725	COG5632	N-Acetylmuramoyl-L-alanine amidase
HT135_11740	COG0457	Tetratricopeptide repeat
HT135_11745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HT135_11770	COG5444	nuclease activity
HT135_11775	COG4282	regulation of fungal-type cell wall biogenesis
HT135_11785	COG1525	nuclease
HT135_11805	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HT135_11810	COG1086	Polysaccharide biosynthesis protein
HT135_11820	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HT135_11825	COG1846	Transcriptional regulator
HT135_11830	COG0534	Mate efflux family protein
HT135_11840	COG4698	Protein conserved in bacteria
HT135_11845	COG2755	lipolytic protein G-D-S-L family
HT135_11850	COG1999	signal sequence binding
HT135_11860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HT135_11865	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HT135_11870	COG1272	protein, Hemolysin III
HT135_11875	COG0204	Acyl-transferase
HT135_11880	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HT135_11890	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HT135_11900	COG2136	Putative SAM-dependent methyltransferase
HT135_11900	COG2521	methyltransferase
HT135_11910	COG0129	dihydroxy-acid dehydratase activity
HT135_11915	COG1413	lyase activity
HT135_11920	COG1418	mRNA catabolic process
HT135_11925	COG0386	Belongs to the glutathione peroxidase family
HT135_11930	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HT135_11935	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HT135_11940	COG1278	Cold shock
HT135_11960	COG0328	RNA-DNA hybrid ribonuclease activity
HT135_11965	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HT135_11970	COG0328	RNA-DNA hybrid ribonuclease activity
HT135_11980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HT135_11995	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HT135_12005	COG1755	Isoprenylcysteine carboxyl methyltransferase
HT135_12010	COG3424	synthase
HT135_12015	COG2233	PERMEase
HT135_12020	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HT135_12025	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HT135_12035	COG0800	Aldolase
HT135_12040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HT135_12045	COG1609	Transcriptional regulator
HT135_12050	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HT135_12055	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_12060	COG1199	ATP-dependent helicase activity
HT135_12075	COG0116	Belongs to the methyltransferase superfamily
HT135_12090	COG4474	Belongs to the UPF0398 family
HT135_12105	COG3359	exonuclease
HT135_12110	COG1111	helicase
HT135_12110	COG1205	dead DEAH box helicase
HT135_12115	COG2190	(PTS) system
HT135_12120	COG0071	Belongs to the small heat shock protein (HSP20) family
HT135_12155	COG3331	DNA recombination
HT135_12160	COG4499	WXG100 protein secretion system (Wss), protein YukC
HT135_12160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HT135_12170	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HT135_12175	COG3935	DnaD domain protein
HT135_12180	COG0017	Asparaginyl-tRNA synthetase
HT135_12185	COG0436	Aminotransferase
HT135_12190	COG5353	protein conserved in bacteria
HT135_12200	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HT135_12200	COG1199	ATP-dependent helicase activity
HT135_12205	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HT135_12210	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HT135_12215	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HT135_12220	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HT135_12220	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HT135_12225	COG0617	tRNA 3'-terminal CCA addition
HT135_12230	COG0438	transferase activity, transferring glycosyl groups
HT135_12235	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HT135_12240	COG1803	Methylglyoxal synthase
HT135_12245	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HT135_12250	COG1694	Mazg nucleotide pyrophosphohydrolase
HT135_12255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HT135_12265	COG4347	Protein of unknown function (DUF1405)
HT135_12270	COG2010	Cytochrome c
HT135_12270	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HT135_12275	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HT135_12280	COG0723	plastoquinol--plastocyanin reductase activity
HT135_12290	COG5582	Belongs to the UPF0302 family
HT135_12295	COG0457	Tetratricopeptide repeat
HT135_12300	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HT135_12305	COG0287	Prephenate dehydrogenase
HT135_12310	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HT135_12315	COG0159	tryptophan synthase activity
HT135_12320	COG0133	tryptophan synthase activity
HT135_12325	COG0135	phosphoribosylanthranilate isomerase activity
HT135_12335	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HT135_12340	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HT135_12345	COG4401	Chorismate mutase type I
HT135_12350	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HT135_12355	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HT135_12360	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HT135_12365	COG0105	UTP biosynthetic process
HT135_12370	COG0142	geranyltranstransferase activity
HT135_12375	COG2226	methyltransferase
HT135_12380	COG0142	geranyltranstransferase activity
HT135_12390	COG0302	gtp cyclohydrolase
HT135_12395	COG0776	regulation of translation
HT135_12400	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HT135_12415	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HT135_12420	COG1160	GTP binding
HT135_12445	COG1304	FMN binding
HT135_12450	COG0539	negative regulation of cytoplasmic translation
HT135_12455	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HT135_12470	COG2959	enzyme of heme biosynthesis
HT135_12475	COG3773	Cell wall hydrolase
HT135_12475	COG3409	Peptidoglycan-binding domain 1 protein
HT135_12480	COG2339	peptidase activity
HT135_12485	COG0492	ferredoxin-NADP+ reductase activity
HT135_12490	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HT135_12495	COG4862	establishment of competence for transformation
HT135_12500	COG1408	metallophosphoesterase
HT135_12510	COG1388	LysM domain
HT135_12515	COG1266	CAAX protease self-immunity
HT135_12520	COG0514	ATP-dependent DNA helicase (RecQ)
HT135_12525	COG4955	Helix-turn-helix domain
HT135_12530	COG1141	Ferredoxin
HT135_12535	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HT135_12540	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HT135_12545	COG0710	3-dehydroquinate dehydratase activity
HT135_12555	COG1595	DNA-templated transcription, initiation
HT135_12560	COG5002	protein histidine kinase activity
HT135_12565	COG0745	RESPONSE REGULATOR receiver
HT135_12570	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HT135_12575	COG1333	cytochrome c biogenesis protein
HT135_12580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HT135_12585	COG1187	pseudouridine synthase activity
HT135_12590	COG0700	Nucleoside recognition
HT135_12595	COG2715	membrane protein required for spore maturation
HT135_12600	COG1686	Belongs to the peptidase S11 family
HT135_12610	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HT135_12615	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HT135_12625	COG1547	Domain of unknown function (DUF309)
HT135_12630	COG0456	acetyltransferase
HT135_12635	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HT135_12640	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HT135_12640	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HT135_12645	COG0307	riboflavin synthase, alpha
HT135_12650	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HT135_12650	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HT135_12660	COG0681	Belongs to the peptidase S26 family
HT135_12665	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
HT135_12670	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HT135_12675	COG4086	secreted protein
HT135_12680	COG0019	diaminopimelate decarboxylase activity
HT135_12685	COG0697	spore germination
HT135_12700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HT135_12720	COG1191	sigma factor activity
HT135_12725	COG2172	sigma factor antagonist activity
HT135_12730	COG1366	Belongs to the anti-sigma-factor antagonist family
HT135_12735	COG1686	Belongs to the peptidase S11 family
HT135_12740	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HT135_12745	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HT135_12750	COG4974	Belongs to the 'phage' integrase family
HT135_12760	COG0735	belongs to the Fur family
HT135_12765	COG1300	Membrane
HT135_12775	COG0281	malic enzyme
HT135_12780	COG1757	Na H antiporter
HT135_12785	COG1027	Aspartate ammonia-lyase
HT135_12790	COG0252	asparaginase activity
HT135_12795	COG1396	sequence-specific DNA binding
HT135_12800	COG1379	DNA repair
HT135_12805	COG0494	nUDIX hydrolase
HT135_12815	COG0667	Aldo Keto reductase
HT135_12825	COG1073	alpha beta
HT135_12835	COG4918	Iron-sulphur cluster biosynthesis
HT135_12840	COG0456	acetyltransferase
HT135_12840	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HT135_12845	COG2329	Antibiotic biosynthesis monooxygenase
HT135_12850	COG0456	acetyltransferase
HT135_12860	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HT135_12870	COG2211	Major facilitator Superfamily
HT135_12880	COG0346	lactoylglutathione lyase activity
HT135_12885	COG1072	(Pantothenic acid kinase))
HT135_12890	COG3048	D-serine ammonia-lyase activity
HT135_12895	COG0300	oxidoreductase activity
HT135_12900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HT135_12905	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HT135_12910	COG4187	Peptidase family M20/M25/M40
HT135_12915	COG1902	pentaerythritol trinitrate reductase activity
HT135_12920	COG0596	Alpha beta hydrolase
HT135_12930	COG1234	tRNA 3'-trailer cleavage
HT135_12935	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HT135_12945	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HT135_12950	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HT135_12960	COG0706	membrane insertase activity
HT135_12970	COG2195	Cleaves the N-terminal amino acid of tripeptides
HT135_12975	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HT135_12980	COG0346	lactoylglutathione lyase activity
HT135_12990	COG1376	ErfK ybiS ycfS ynhG family protein
HT135_12995	COG4129	membrane
HT135_13000	COG1126	abc transporter atp-binding protein
HT135_13005	COG0765	amino acid transport
HT135_13010	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HT135_13020	COG1597	lipid kinase activity
HT135_13025	COG2814	Major facilitator Superfamily
HT135_13030	COG0789	Transcriptional regulator
HT135_13030	COG4978	Transcriptional regulator
HT135_13035	COG0508	dehydrogenase complex catalyzes the overall conversion of
HT135_13040	COG0022	dehydrogenase e1 component
HT135_13045	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HT135_13050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HT135_13055	COG3426	butyrate kinase activity
HT135_13060	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HT135_13065	COG0280	phosphate acetyltransferase
HT135_13070	COG3290	protein histidine kinase activity
HT135_13070	COG3829	transcription factor binding
HT135_13080	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HT135_13085	COG2079	MmgE PrpD family protein
HT135_13090	COG0372	Belongs to the citrate synthase family
HT135_13095	COG1960	acyl-CoA dehydrogenase activity
HT135_13100	COG1250	3-hydroxyacyl-CoA dehydrogenase
HT135_13105	COG0183	Belongs to the thiolase family
HT135_13110	COG0584	glycerophosphoryl diester phosphodiesterase
HT135_13115	COG0860	N-Acetylmuramoyl-L-alanine amidase
HT135_13130	COG1902	pentaerythritol trinitrate reductase activity
HT135_13135	COG0745	RESPONSE REGULATOR receiver
HT135_13140	COG0750	zinc metalloprotease
HT135_13145	COG0497	DNA recombination
HT135_13150	COG1438	arginine binding
HT135_13155	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HT135_13160	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HT135_13165	COG0142	geranyltranstransferase activity
HT135_13170	COG1722	exodeoxyribonuclease VII activity
HT135_13175	COG1570	exodeoxyribonuclease VII activity
HT135_13180	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HT135_13185	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HT135_13190	COG1302	Protein conserved in bacteria
HT135_13195	COG0439	Biotin carboxylase
HT135_13200	COG0511	ligase activity, forming carbon-carbon bonds
HT135_13240	COG3854	ATPases associated with a variety of cellular activities
HT135_13250	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HT135_13255	COG0006	proline dipeptidase activity
HT135_13260	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HT135_13270	COG3872	metal-dependent enzyme
HT135_13280	COG1752	Esterase of the alpha-beta hydrolase superfamily
HT135_13285	COG1321	iron dependent repressor
HT135_13290	COG0095	Lipoate-protein ligase
HT135_13295	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HT135_13300	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HT135_13305	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HT135_13310	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HT135_13315	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HT135_13330	COG1396	sequence-specific DNA binding
HT135_13340	COG0681	Belongs to the peptidase S26 family
HT135_13365	COG4940	Competence protein ComGF
HT135_13375	COG4970	Tfp pilus assembly protein FimT
HT135_13380	COG4537	Required for transformation and DNA binding
HT135_13385	COG1459	type II secretion system
HT135_13390	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HT135_13395	COG0517	IMP dehydrogenase activity
HT135_13400	COG0598	Magnesium transport protein CorA
HT135_13405	COG1253	flavin adenine dinucleotide binding
HT135_13410	COG1366	Belongs to the anti-sigma-factor antagonist family
HT135_13420	COG1393	Belongs to the ArsC family
HT135_13430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HT135_13440	COG0011	TIGRFAM Protein of
HT135_13450	COG2866	Carboxypeptidase
HT135_13455	COG1368	sulfuric ester hydrolase activity
HT135_13460	COG1940	carbohydrate kinase activity
HT135_13465	COG4483	Protein conserved in bacteria
HT135_13470	COG0705	Rhomboid family
HT135_13470	COG0457	Tetratricopeptide repeat
HT135_13480	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HT135_13490	COG0438	transferase activity, transferring glycosyl groups
HT135_13505	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HT135_13510	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HT135_13515	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HT135_13520	COG0581	inorganic phosphate transmembrane transporter activity
HT135_13525	COG0573	inorganic phosphate transmembrane transporter activity
HT135_13530	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HT135_13540	COG0477	Major facilitator Superfamily
HT135_13545	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HT135_13550	COG2839	Protein conserved in bacteria
HT135_13555	COG5521	maltodextrose utilization protein MalA
HT135_13560	COG1388	LysM domain
HT135_13565	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HT135_13570	COG4709	membrane
HT135_13575	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HT135_13580	COG0735	belongs to the Fur family
HT135_13585	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HT135_13595	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HT135_13600	COG0513	Belongs to the DEAD box helicase family
HT135_13610	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HT135_13615	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HT135_13620	COG2384	SAM-dependent methyltransferase
HT135_13625	COG2010	Cytochrome c
HT135_13630	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HT135_13635	COG0358	DNA primase activity
HT135_13640	COG1671	Belongs to the UPF0178 family
HT135_13645	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HT135_13650	COG0517	IMP dehydrogenase activity
HT135_13655	COG0751	glycine-tRNA ligase activity
HT135_13660	COG0752	glycyl-tRNA synthetase alpha subunit
HT135_13665	COG1381	Involved in DNA repair and RecF pathway recombination
HT135_13675	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HT135_13680	COG0295	cytidine deaminase activity
HT135_13685	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HT135_13690	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HT135_13695	COG1480	7TM receptor with intracellular HD hydrolase
HT135_13700	COG1702	phosphate starvation-inducible protein PhoH
HT135_13705	COG0561	phosphatase activity
HT135_13720	COG4864	UPF0365 protein
HT135_13725	COG1030	water channel activity
HT135_13730	COG1610	YqeY-like protein
HT135_13740	COG1283	sodium-dependent phosphate transmembrane transporter activity
HT135_13745	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HT135_13750	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HT135_13755	COG2264	protein methyltransferase activity
HT135_13760	COG0484	heat shock protein binding
HT135_13770	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HT135_13775	COG1420	regulation of RNA biosynthetic process
HT135_13780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HT135_13785	COG0481	GTPase activity
HT135_13795	COG0860	N-Acetylmuramoyl-L-alanine amidase
HT135_13800	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HT135_13810	COG1466	dna polymerase III delta subunit
HT135_13825	COG0658	competence protein
HT135_13825	COG2333	competence protein COMEC
HT135_13830	COG2131	deaminase
HT135_13835	COG1596	polysaccharide export
HT135_13835	COG1555	photosystem II stabilization
HT135_13840	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HT135_13845	COG2226	methyltransferase
HT135_13850	COG0799	negative regulation of ribosome biogenesis
HT135_13855	COG1713	HD superfamily hydrolase involved in NAD metabolism
HT135_13860	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HT135_13865	COG1534	Rna-binding protein
HT135_13870	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HT135_13875	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HT135_13880	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HT135_13890	COG2755	lipolytic protein G-D-S-L family
HT135_13895	COG5632	N-Acetylmuramoyl-L-alanine amidase
HT135_13895	COG3409	Peptidoglycan-binding domain 1 protein
HT135_13900	COG0398	Pfam SNARE associated Golgi protein
HT135_13905	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HT135_13915	COG3209	COG3209 Rhs family protein
HT135_13950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HT135_13965	COG2814	Major facilitator Superfamily
HT135_13970	COG0457	Tetratricopeptide repeat
HT135_13975	COG2072	flavoprotein involved in K transport
HT135_13980	COG1230	cation diffusion facilitator family transporter
HT135_14000	COG5444	nuclease activity
HT135_14010	COG0697	spore germination
HT135_14015	COG3409	Peptidoglycan-binding domain 1 protein
HT135_14015	COG5632	N-Acetylmuramoyl-L-alanine amidase
HT135_14020	COG4824	toxin secretion phage lysis holin
HT135_14080	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HT135_14100	COG0563	adenylate kinase activity
HT135_14120	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HT135_14125	COG1733	regulation of RNA biosynthetic process
HT135_14160	COG2732	(Barnase) inhibitor
HT135_14190	COG1725	Transcriptional regulator
HT135_14205	COG0747	negative chemotaxis
HT135_14210	COG0601	transmembrane transport
HT135_14215	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HT135_14220	COG0444	Belongs to the ABC transporter superfamily
HT135_14225	COG4608	Belongs to the ABC transporter superfamily
HT135_14235	COG3443	Belongs to the bacterial solute-binding protein 9 family
HT135_14245	COG4991	sh3 domain protein
HT135_14250	COG4991	sh3 domain protein
HT135_14275	COG0789	Transcriptional regulator
HT135_14280	COG1064	alcohol dehydrogenase
HT135_14285	COG0693	protein deglycase activity
HT135_14290	COG1621	beta-fructofuranosidase activity
HT135_14295	COG3716	PTS system mannose fructose sorbose family IID component
HT135_14300	COG3715	PTS system
HT135_14305	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT135_14310	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT135_14315	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HT135_14315	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HT135_14320	COG1113	amino acid transport
HT135_14325	COG1280	lysine exporter protein (LysE YggA)
HT135_14330	COG1378	Sugar-specific transcriptional regulator TrmB
HT135_14335	COG1595	DNA-templated transcription, initiation
HT135_14345	COG2755	lipolytic protein G-D-S-L family
HT135_14345	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HT135_14355	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HT135_14355	COG2124	cytochrome p450
HT135_14360	COG1309	transcriptional regulator
HT135_14365	COG2226	methyltransferase
HT135_14380	COG2116	formate transmembrane transporter activity
HT135_14385	COG5609	conserved protein (DUF2294)
HT135_14390	COG3383	formate dehydrogenase (NAD+) activity
HT135_14395	COG2427	Protein of unknown function (DUF1641)
HT135_14405	COG0626	cystathionine gamma-synthase activity
HT135_14410	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HT135_14415	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HT135_14420	COG2226	methyltransferase
HT135_14435	COG0768	penicillin binding
HT135_14440	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HT135_14445	COG0572	uridine kinase
HT135_14460	COG4122	O-methyltransferase activity
HT135_14465	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HT135_14470	COG3906	Belongs to the UPF0473 family
HT135_14475	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HT135_14480	COG4472	Bacterial protein of unknown function (DUF965)
HT135_14485	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HT135_14490	COG0628	permease
HT135_14495	COG1126	abc transporter atp-binding protein
HT135_14500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HT135_14505	COG0765	amino acid transport
HT135_14510	COG0765	amino acid transport
HT135_14525	COG3881	PFAM PRC-barrel domain
HT135_14530	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HT135_14535	COG0457	Tetratricopeptide repeat
HT135_14540	COG0482	sulfurtransferase activity
HT135_14545	COG1104	cysteine desulfurase activity
HT135_14550	COG1959	2 iron, 2 sulfur cluster binding
HT135_14555	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HT135_14560	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HT135_14570	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HT135_14575	COG0124	histidyl-tRNA synthetase
HT135_14585	COG4991	sh3 domain protein
HT135_14585	COG3103	Sh3 type 3 domain protein
HT135_14585	COG0860	N-Acetylmuramoyl-L-alanine amidase
HT135_14590	COG1490	D-aminoacyl-tRNA deacylase activity
HT135_14595	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HT135_14600	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HT135_14605	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HT135_14605	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HT135_14610	COG5416	Lipopolysaccharide assembly protein A domain
HT135_14615	COG0490	domain, Protein
HT135_14620	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HT135_14620	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HT135_14630	COG2244	polysaccharide biosynthetic process
HT135_14635	COG2323	membrane
HT135_14645	COG1862	Preprotein translocase
HT135_14650	COG0343	queuine tRNA-ribosyltransferase activity
HT135_14655	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HT135_14665	COG2255	four-way junction helicase activity
HT135_14670	COG0632	four-way junction helicase activity
HT135_14680	COG2814	Major facilitator Superfamily
HT135_14685	COG0673	inositol 2-dehydrogenase activity
HT135_14690	COG2112	serine threonine protein kinase
HT135_14705	COG1115	amino acid carrier protein
HT135_14710	COG0217	transcriptional regulatory protein
HT135_14720	COG1388	LysM domain
HT135_14725	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HT135_14730	COG0157	Belongs to the NadC ModD family
HT135_14735	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HT135_14740	COG1104	cysteine desulfurase activity
HT135_14745	COG1827	regulation of RNA biosynthetic process
HT135_14750	COG0077	Prephenate dehydratase
HT135_14755	COG4492	Belongs to the UPF0735 family
HT135_14760	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HT135_14765	COG3290	protein histidine kinase activity
HT135_14775	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HT135_14780	COG2868	ribosomal protein
HT135_14785	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HT135_14790	COG1994	Peptidase M50
HT135_14795	COG0739	heme binding
HT135_14800	COG2894	cell division
HT135_14805	COG0850	regulation of cytokinetic process
HT135_14810	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HT135_14820	COG1077	Cell shape determining protein MreB Mrl
HT135_14825	COG2003	Belongs to the UPF0758 family
HT135_14830	COG0424	maF-like protein
HT135_14840	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HT135_14845	COG0285	dihydrofolate synthase activity
HT135_14850	COG0525	valine-tRNA ligase activity
HT135_14860	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HT135_14865	COG1388	LysM domain
HT135_14870	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HT135_14875	COG0113	porphobilinogen synthase activity
HT135_14880	COG1587	Uroporphyrinogen-III synthase
HT135_14885	COG0181	hydroxymethylbilane synthase activity
HT135_14890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HT135_14895	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HT135_14905	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HT135_14910	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HT135_14915	COG0470	DNA polymerase III
HT135_14915	COG1067	ATP-dependent peptidase activity
HT135_14920	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HT135_14925	COG0544	peptidyl-prolyl cis-trans isomerase activity
HT135_14930	COG1477	protein flavinylation
HT135_14930	COG0457	Tetratricopeptide repeat
HT135_14935	COG0066	3-isopropylmalate dehydratase activity
HT135_14940	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HT135_14945	COG0473	3-isopropylmalate dehydrogenase activity
HT135_14950	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HT135_14955	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HT135_14960	COG0440	acetolactate synthase activity
HT135_14965	COG0028	Belongs to the TPP enzyme family
HT135_14975	COG0454	-acetyltransferase
HT135_14980	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HT135_14990	COG0622	Phosphoesterase
HT135_14995	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HT135_15000	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HT135_15005	COG5401	PFAM Sporulation and spore germination
HT135_15010	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HT135_15015	COG1846	Transcriptional regulator
HT135_15020	COG2197	response regulator
HT135_15025	COG0824	Thioesterase
HT135_15030	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HT135_15035	COG1053	succinate dehydrogenase
HT135_15040	COG2009	succinate dehydrogenase
HT135_15045	COG1719	4-vinyl reductase, 4VR
HT135_15050	COG0527	aspartate kinase activity
HT135_15060	COG0322	excinuclease ABC activity
HT135_15065	COG3118	belongs to the thioredoxin family
HT135_15070	COG3534	alpha-L-arabinofuranosidase
HT135_15075	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HT135_15080	COG2086	electron transfer activity
HT135_15085	COG1024	Enoyl-CoA hydratase
HT135_15090	COG1309	transcriptional regulator
HT135_15095	COG0318	PFAM AMP-dependent synthetase and ligase
HT135_15100	COG3766	membrane
HT135_15105	COG1193	negative regulation of DNA recombination
HT135_15110	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HT135_15110	COG1796	DNA polymerase
HT135_15115	COG1286	toxin biosynthetic process
HT135_15120	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HT135_15125	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HT135_15130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HT135_15130	COG0072	phenylalanine-tRNA ligase activity
HT135_15135	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HT135_15145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HT135_15155	COG3835	regulator
HT135_15160	COG0277	FAD linked oxidase domain protein
HT135_15165	COG0247	lactate metabolic process
HT135_15170	COG0346	lactoylglutathione lyase activity
HT135_15175	COG1966	Carbon starvation protein
HT135_15190	COG1695	Transcriptional regulator
HT135_15195	COG3534	alpha-L-arabinofuranosidase
HT135_15200	COG0395	ABC-type sugar transport system, permease component
HT135_15205	COG1175	transmembrane transport
HT135_15210	COG1653	transport
HT135_15215	COG0371	Dehydrogenase
HT135_15220	COG0647	UMP catabolic process
HT135_15225	COG0235	Class ii aldolase
HT135_15230	COG1069	ribulokinase activity
HT135_15235	COG2160	L-arabinose isomerase activity
HT135_15240	COG3507	Belongs to the glycosyl hydrolase 43 family
HT135_15245	COG1363	Peptidase, m42
HT135_15255	COG3326	Membrane
HT135_15260	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HT135_15265	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HT135_15270	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HT135_15280	COG1346	cytolysis
HT135_15285	COG1380	Effector of murein hydrolase LrgA
HT135_15290	COG3279	Response regulator of the LytR AlgR family
HT135_15295	COG3275	phosphorelay sensor kinase activity
HT135_15300	COG1011	Hydrolase
HT135_15305	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HT135_15315	COG0398	Pfam SNARE associated Golgi protein
HT135_15320	COG1484	DNA-dependent DNA replication
HT135_15325	COG3611	Membrane attachment protein
HT135_15330	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HT135_15335	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HT135_15340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HT135_15345	COG1733	regulation of RNA biosynthetic process
HT135_15350	COG2814	Major facilitator Superfamily
HT135_15355	COG0656	L-ascorbic acid biosynthetic process
HT135_15360	COG0237	dephospho-CoA kinase activity
HT135_15365	COG1971	Probably functions as a manganese efflux pump
HT135_15370	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HT135_15375	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HT135_15375	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HT135_15380	COG5002	protein histidine kinase activity
HT135_15385	COG0745	RESPONSE REGULATOR receiver
HT135_15390	COG0039	L-malate dehydrogenase activity
HT135_15395	COG0538	isocitrate dehydrogenase activity
HT135_15400	COG0372	Belongs to the citrate synthase family
HT135_15405	COG2707	UPF0756 membrane protein
HT135_15410	COG0628	permease
HT135_15415	COG3030	protein affecting phage T7 exclusion by the F plasmid
HT135_15420	COG0469	pyruvate kinase activity
HT135_15425	COG0205	6-phosphofructokinase activity
HT135_15430	COG0825	malonyl-CoA metabolic process
HT135_15435	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HT135_15440	COG0281	malic enzyme
HT135_15445	COG0587	DNA-directed DNA polymerase activity
HT135_15465	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HT135_15475	COG4109	DRTGG domain
HT135_15480	COG0730	response to heat
HT135_15485	COG1473	amidohydrolase
HT135_15490	COG0196	riboflavin kinase activity
HT135_15495	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HT135_15500	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HT135_15505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HT135_15510	COG1126	abc transporter atp-binding protein
HT135_15515	COG0765	amino acid transport
HT135_15520	COG0765	amino acid transport
HT135_15525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HT135_15530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HT135_15535	COG0454	-acetyltransferase
HT135_15540	COG0583	DNA-binding transcription factor activity
HT135_15545	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HT135_15550	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_15555	COG0165	Argininosuccinate lyase
HT135_15560	COG0137	argininosuccinate synthase activity
HT135_15565	COG0521	Mo-molybdopterin cofactor biosynthetic process
HT135_15570	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HT135_15575	COG0827	DNA restriction-modification system
HT135_15580	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HT135_15585	COG3874	Sporulation protein YtfJ
HT135_15595	COG1714	RDD family
HT135_15600	COG0616	signal peptide processing
HT135_15605	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HT135_15610	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HT135_15615	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HT135_15625	COG0301	tRNA thio-modification
HT135_15630	COG1104	cysteine desulfurase activity
HT135_15635	COG1114	Component of the transport system for branched-chain amino acids
HT135_15640	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HT135_15645	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HT135_15650	COG1309	transcriptional regulator
HT135_15655	COG1956	GAF domain-containing protein
HT135_15660	COG2203	Gaf domain
HT135_15660	COG2199	diguanylate cyclase activity
HT135_15670	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HT135_15675	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HT135_15680	COG0454	-acetyltransferase
HT135_15685	COG0517	IMP dehydrogenase activity
HT135_15690	COG0123	including yeast histone deacetylase and acetoin utilization protein
HT135_15695	COG1360	Flagellar Motor Protein
HT135_15700	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HT135_15705	COG1609	Transcriptional regulator
HT135_15710	COG1605	Chorismate mutase
HT135_15710	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HT135_15715	COG3118	belongs to the thioredoxin family
HT135_15720	COG4980	gas vesicle protein
HT135_15725	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HT135_15730	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HT135_15735	COG1674	ftsk spoiiie
HT135_15740	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HT135_15745	COG4848	Belongs to the UPF0354 family
HT135_15750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HT135_15765	COG1363	Peptidase, m42
HT135_15770	COG5584	Small secreted protein
HT135_15775	COG0281	malic enzyme
HT135_15780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HT135_15785	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HT135_15795	COG0510	thiamine kinase activity
HT135_15800	COG1523	belongs to the glycosyl hydrolase 13 family
HT135_15805	COG1597	lipid kinase activity
HT135_15815	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HT135_15820	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HT135_15825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HT135_15830	COG2252	PERMEase
HT135_15835	COG4473	ABC transporter
HT135_15840	COG1131	(ABC) transporter
HT135_15845	COG1349	DNA-binding transcription factor activity
HT135_15850	COG1187	pseudouridine synthase activity
HT135_15855	COG2244	polysaccharide biosynthetic process
HT135_15860	COG2081	HI0933 family
HT135_15865	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HT135_15875	COG5578	integral membrane protein
HT135_15880	COG0673	inositol 2-dehydrogenase activity
HT135_15885	COG1653	transport
HT135_15890	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HT135_15895	COG4209	transmembrane transport
HT135_15900	COG2207	Transcriptional regulator
HT135_15905	COG1653	transport
HT135_15910	COG0395	ABC-type sugar transport system, permease component
HT135_15915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HT135_15920	COG2124	cytochrome p450
HT135_15925	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HT135_15935	COG0156	8-amino-7-oxononanoate synthase activity
HT135_15940	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HT135_15950	COG1073	alpha beta
HT135_15955	COG1609	Transcriptional regulator
HT135_15960	COG1653	transport
HT135_15965	COG1175	transmembrane transport
HT135_15970	COG0395	ABC-type sugar transport system, permease component
HT135_15975	COG1486	melibiose metabolic process
HT135_15980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HT135_15985	COG0495	leucyl-tRNA aminoacylation
HT135_15995	COG1366	Belongs to the anti-sigma-factor antagonist family
HT135_15995	COG2202	Pas domain
HT135_16000	COG2814	Major facilitator Superfamily
HT135_16005	COG2433	Pfam Transposase IS66
HT135_16010	COG0577	efflux transmembrane transporter activity
HT135_16015	COG1136	(ABC) transporter
HT135_16020	COG2205	protein histidine kinase activity
HT135_16025	COG0745	RESPONSE REGULATOR receiver
HT135_16030	COG0577	efflux transmembrane transporter activity
HT135_16035	COG1136	(ABC) transporter
HT135_16050	COG1131	(ABC) transporter
HT135_16055	COG1725	Transcriptional regulator
HT135_16070	COG1242	4 iron, 4 sulfur cluster binding
HT135_16075	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HT135_16085	COG2267	carboxylic ester hydrolase activity
HT135_16090	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HT135_16095	COG1113	amino acid transport
HT135_16100	COG0367	asparagine synthase
HT135_16105	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HT135_16110	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HT135_16120	COG1506	peptidase
HT135_16125	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HT135_16130	COG1116	anion transmembrane transporter activity
HT135_16135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HT135_16140	COG0494	nUDIX hydrolase
HT135_16145	COG4824	toxin secretion phage lysis holin
HT135_16150	COG0783	Belongs to the Dps family
HT135_16165	COG1854	S-ribosylhomocysteine lyase activity
HT135_16170	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HT135_16175	COG0288	reversible hydration of carbon dioxide
HT135_16180	COG0254	rRNA binding
HT135_16185	COG1271	oxidase subunit
HT135_16190	COG1294	oxidase, subunit
HT135_16200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HT135_16205	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HT135_16205	COG1321	iron dependent repressor
HT135_16210	COG1121	(ABC) transporter
HT135_16215	COG0803	Belongs to the bacterial solute-binding protein 9 family
HT135_16220	COG4948	Mandelate Racemase Muconate Lactonizing
HT135_16225	COG0318	PFAM AMP-dependent synthetase and ligase
HT135_16230	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HT135_16235	COG0596	Alpha beta hydrolase
HT135_16240	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HT135_16245	COG1169	isochorismate synthase
HT135_16250	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HT135_16255	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HT135_16260	COG0058	SHG alpha-glucan phosphorylase activity
HT135_16265	COG0297	glycogen (starch) synthase activity
HT135_16270	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HT135_16275	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HT135_16280	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HT135_16405	COG3859	Proton-coupled thiamine transporter YuaJ
HT135_16410	COG1247	-acetyltransferase
HT135_16415	COG2268	Band 7 protein
HT135_16420	COG1585	Membrane protein implicated in regulation of membrane protease activity
HT135_16425	COG2318	DinB family
HT135_16435	COG1454	alcohol dehydrogenase
HT135_16440	COG1012	belongs to the aldehyde dehydrogenase family
HT135_16445	COG1510	regulation of RNA biosynthetic process
HT135_16455	COG0569	domain protein
HT135_16460	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HT135_16465	COG4682	membrane
HT135_16470	COG1705	Flagellar rod assembly protein muramidase FlgJ
HT135_16475	COG0477	Major facilitator Superfamily
HT135_16480	COG5553	Cysteine dioxygenase type I
HT135_16490	COG1968	undecaprenyl-diphosphatase activity
HT135_16495	COG0628	permease
HT135_16500	COG0673	inositol 2-dehydrogenase activity
HT135_16505	COG4806	L-rhamnose isomerase
HT135_16510	COG3254	rhamnose metabolic process
HT135_16515	COG1070	Carbohydrate kinase
HT135_16520	COG1349	DNA-binding transcription factor activity
HT135_16525	COG3347	Dehydrogenase
HT135_16525	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_16530	COG0840	transmembrane signaling receptor activity
HT135_16535	COG0840	transmembrane signaling receptor activity
HT135_16540	COG0840	transmembrane signaling receptor activity
HT135_16545	COG0840	transmembrane signaling receptor activity
HT135_16560	COG2070	2-Nitropropane dioxygenase
HT135_16565	COG0432	Pfam Uncharacterised protein family UPF0047
HT135_16570	COG0366	Alpha amylase catalytic
HT135_16575	COG1253	flavin adenine dinucleotide binding
HT135_16580	COG2738	Putative neutral zinc metallopeptidase
HT135_16595	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HT135_16610	COG0166	Belongs to the GPI family
HT135_16615	COG1979	alcohol dehydrogenase
HT135_16620	COG1979	alcohol dehydrogenase
HT135_16625	COG2155	Conserved Protein
HT135_16630	COG1098	S1 RNA binding domain
HT135_16635	COG0436	Aminotransferase
HT135_16640	COG1522	sequence-specific DNA binding
HT135_16645	COG2267	carboxylic ester hydrolase activity
HT135_16655	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HT135_16660	COG2205	protein histidine kinase activity
HT135_16670	COG5018	Exonuclease
HT135_16675	COG2814	Major facilitator Superfamily
HT135_16680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HT135_16685	COG3011	Protein conserved in bacteria
HT135_16695	COG3290	protein histidine kinase activity
HT135_16700	COG4565	transcriptional regulatory protein
HT135_16725	COG3493	citrate carrier protein
HT135_16735	COG2111	Na H antiporter
HT135_16735	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HT135_16740	COG2111	Na H antiporter
HT135_16745	COG1006	Multisubunit Na H antiporter MnhC subunit
HT135_16750	COG0651	ATP synthesis coupled electron transport
HT135_16755	COG1863	multisubunit Na H antiporter MnhE subunit
HT135_16760	COG2212	antiporter activity
HT135_16765	COG1320	monovalent cation:proton antiporter activity
HT135_16770	COG2050	protein possibly involved in aromatic compounds catabolism
HT135_16775	COG2197	response regulator
HT135_16790	COG0142	geranyltranstransferase activity
HT135_16805	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HT135_16810	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HT135_16815	COG1335	isochorismatase
HT135_16820	COG5506	Protein of unknown function (DUF1694)
HT135_16835	COG0628	permease
HT135_16845	COG1418	mRNA catabolic process
HT135_16850	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_16860	COG1511	domain protein
HT135_16865	COG1674	ftsk spoiiie
HT135_16865	COG0433	COG0433 Predicted ATPase
HT135_16870	COG4499	WXG100 protein secretion system (Wss), protein YukC
HT135_16875	COG5417	Belongs to the EsaB family
HT135_16880	COG4842	Belongs to the WXG100 family
HT135_16885	COG2508	Transcriptional regulator
HT135_16885	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HT135_16890	COG0686	Belongs to the AlaDH PNT family
HT135_16895	COG5634	Uncharacterized conserved protein (DUF2278)
HT135_16900	COG3251	PFAM MbtH domain protein
HT135_16905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_16910	COG3433	isochorismatase activity
HT135_16910	COG1535	isochorismatase
HT135_16915	COG1021	2,3-dihydroxybenzoate-AMP ligase
HT135_16920	COG1169	isochorismate synthase
HT135_16925	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_16930	COG2819	hydrolase of the alpha beta superfamily
HT135_16935	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HT135_16940	COG1268	BioY protein
HT135_16945	COG2056	Na+-H+ antiporter family
HT135_16950	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HT135_16955	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HT135_16960	COG3584	3D domain protein
HT135_16975	COG1252	NADH dehydrogenase
HT135_16980	COG0492	ferredoxin-NADP+ reductase activity
HT135_16990	COG0516	GMP reductase activity
HT135_16995	COG0316	Belongs to the HesB IscA family
HT135_17000	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HT135_17005	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HT135_17010	COG4844	belongs to the
HT135_17015	COG1252	NADH dehydrogenase
HT135_17020	COG4837	Protein of unknown function (DUF1462)
HT135_17025	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HT135_17030	COG4946	Tricorn protease homolog
HT135_17030	COG0823	Involved in the tonB-independent uptake of proteins
HT135_17030	COG1506	peptidase
HT135_17035	COG0083	homoserine kinase activity
HT135_17040	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HT135_17045	COG0460	homoserine dehydrogenase
HT135_17050	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HT135_17055	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HT135_17060	COG0647	UMP catabolic process
HT135_17065	COG2445	Protein of unknown function DUF86
HT135_17070	COG4470	Protein conserved in bacteria
HT135_17085	COG0739	heme binding
HT135_17095	COG3377	Domain of unknown function (DUF1805)
HT135_17100	COG0737	Belongs to the 5'-nucleotidase family
HT135_17105	COG0730	response to heat
HT135_17110	COG1801	Protein of unknown function DUF72
HT135_17120	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HT135_17125	COG2508	Transcriptional regulator
HT135_17130	COG2233	PERMEase
HT135_17135	COG2233	PERMEase
HT135_17140	COG3195	allantoin biosynthetic process
HT135_17140	COG3648	Uricase
HT135_17145	COG2351	hydroxyisourate hydrolase activity
HT135_17155	COG2080	2 iron, 2 sulfur cluster binding
HT135_17160	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HT135_17165	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HT135_17170	COG2068	MobA-Related Protein
HT135_17175	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HT135_17180	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HT135_17185	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HT135_17190	COG2356	endonuclease I
HT135_17195	COG3842	ATPase activity
HT135_17200	COG2188	Transcriptional regulator
HT135_17205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HT135_17210	COG0395	ABC-type sugar transport system, permease component
HT135_17215	COG1175	transmembrane transport
HT135_17220	COG1653	transport
HT135_17225	COG2222	sugar isomerase
HT135_17230	COG0322	excinuclease ABC activity
HT135_17235	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HT135_17255	COG0719	Fe-S assembly protein
HT135_17260	COG0822	iron-sulfur transferase activity
HT135_17265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HT135_17270	COG0719	Fe-S assembly protein
HT135_17275	COG0396	ATPase activity
HT135_17285	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HT135_17290	COG1464	Belongs to the NlpA lipoprotein family
HT135_17295	COG2011	ABC-type metal ion transport system permease component
HT135_17300	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HT135_17310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HT135_17315	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HT135_17325	COG0509	glycine decarboxylation via glycine cleavage system
HT135_17330	COG1393	Belongs to the ArsC family
HT135_17335	COG1960	acyl-CoA dehydrogenase activity
HT135_17340	COG0183	Belongs to the thiolase family
HT135_17345	COG1250	3-hydroxyacyl-CoA dehydrogenase
HT135_17345	COG1024	Enoyl-CoA hydratase
HT135_17355	COG0506	proline dehydrogenase activity
HT135_17365	COG5577	PFAM Coat F domain
HT135_17370	COG1846	Transcriptional regulator
HT135_17375	COG0477	Major facilitator Superfamily
HT135_17380	COG1942	4-Oxalocrotonate Tautomerase
HT135_17385	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_17390	COG0583	DNA-binding transcription factor activity
HT135_17400	COG1120	ATPase activity
HT135_17415	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_17420	COG0783	Belongs to the Dps family
HT135_17425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HT135_17430	COG0745	RESPONSE REGULATOR receiver
HT135_17435	COG2205	protein histidine kinase activity
HT135_17435	COG2770	Histidine kinase
HT135_17445	COG1309	transcriptional regulator
HT135_17450	COG0114	fumarate hydratase activity
HT135_17460	COG0697	spore germination
HT135_17465	COG0814	amino acid
HT135_17475	COG2197	response regulator
HT135_17480	COG4585	Histidine kinase
HT135_17485	COG4758	membrane
HT135_17490	COG3595	metallopeptidase activity
HT135_17495	COG1842	Phage shock protein A
HT135_17500	COG4758	membrane
HT135_17505	COG2814	Major facilitator Superfamily
HT135_17510	COG2096	Adenosyltransferase
HT135_17515	COG1120	ATPase activity
HT135_17520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HT135_17525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HT135_17530	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_17535	COG3386	PFAM SMP-30 Gluconolaconase
HT135_17540	COG2205	protein histidine kinase activity
HT135_17545	COG0745	RESPONSE REGULATOR receiver
HT135_17555	COG1191	sigma factor activity
HT135_17565	COG2140	Oxalate decarboxylase
HT135_17575	COG0577	efflux transmembrane transporter activity
HT135_17580	COG1136	(ABC) transporter
HT135_17585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HT135_17590	COG1120	ATPase activity
HT135_17595	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HT135_17600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HT135_17605	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HT135_17610	COG0531	amino acid
HT135_17620	COG1988	membrane-bound metal-dependent
HT135_17625	COG1368	sulfuric ester hydrolase activity
HT135_17630	COG1910	domain protein
HT135_17635	COG0725	ABC transporter, periplasmic molybdate-binding protein
HT135_17640	COG4149	molybdate abc transporter
HT135_17645	COG0656	L-ascorbic acid biosynthetic process
HT135_17655	COG0025	NhaP-type Na H and K H
HT135_17660	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HT135_17665	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HT135_17670	COG3973	AAA domain
HT135_17680	COG2860	membrane
HT135_17685	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HT135_17690	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HT135_17695	COG2217	Heavy metal translocating P-type atpase
HT135_17700	COG2217	Heavy metal translocating P-type atpase
HT135_17705	COG2608	mercury ion transmembrane transporter activity
HT135_17710	COG1937	Protein conserved in bacteria
HT135_17715	COG0673	inositol 2-dehydrogenase activity
HT135_17720	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HT135_17725	COG1289	transmembrane transporter activity
HT135_17730	COG1802	Transcriptional regulator
HT135_17735	COG0697	spore germination
HT135_17745	COG2076	Multidrug Resistance protein
HT135_17750	COG1309	transcriptional regulator
HT135_17755	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_17765	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HT135_17770	COG0557	exoribonuclease II activity
HT135_17775	COG1647	Serine aminopeptidase, S33
HT135_17780	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HT135_17785	COG0596	Alpha beta hydrolase
HT135_17790	COG1476	TRANSCRIPTIONal
HT135_17795	COG1396	sequence-specific DNA binding
HT135_17800	COG1396	sequence-specific DNA binding
HT135_17805	COG1733	regulation of RNA biosynthetic process
HT135_17810	COG0840	transmembrane signaling receptor activity
HT135_17815	COG1174	glycine betaine transport
HT135_17820	COG1732	Glycine betaine
HT135_17825	COG1174	glycine betaine transport
HT135_17830	COG1125	glycine betaine transport
HT135_17830	COG0517	IMP dehydrogenase activity
HT135_17835	COG1510	regulation of RNA biosynthetic process
HT135_17855	COG5658	integral membrane protein
HT135_17860	COG0640	Transcriptional regulator
HT135_17865	COG1174	glycine betaine transport
HT135_17870	COG1732	Glycine betaine
HT135_17875	COG1174	glycine betaine transport
HT135_17880	COG0517	IMP dehydrogenase activity
HT135_17880	COG1125	glycine betaine transport
HT135_17885	COG1510	regulation of RNA biosynthetic process
HT135_17895	COG3064	Membrane
HT135_17900	COG4640	response to antibiotic
HT135_17905	COG0456	acetyltransferase
HT135_17920	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HT135_17940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HT135_17945	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HT135_17955	COG2234	aminopeptidase activity
HT135_17965	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HT135_17970	COG0149	triose-phosphate isomerase activity
HT135_17975	COG0126	phosphoglycerate kinase activity
HT135_17980	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HT135_17985	COG2390	Transcriptional regulator
HT135_17990	COG2814	Major facilitator Superfamily
HT135_17995	COG1609	Transcriptional regulator
HT135_18000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HT135_18005	COG0583	DNA-binding transcription factor activity
HT135_18010	COG0697	spore germination
HT135_18015	COG1113	amino acid transport
HT135_18020	COG3858	chitin binding
HT135_18025	COG1556	Lactate utilization protein
HT135_18030	COG1139	Iron-sulfur cluster binding protein
HT135_18035	COG0247	lactate metabolic process
HT135_18040	COG2197	response regulator
HT135_18045	COG4585	Histidine kinase
HT135_18050	COG0842	Transport permease protein
HT135_18055	COG1131	(ABC) transporter
HT135_18060	COG0596	Alpha beta hydrolase
HT135_18065	COG2208	phosphoserine phosphatase activity
HT135_18070	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HT135_18075	COG1874	Beta-galactosidase
HT135_18080	COG3833	ABC-type maltose transport systems, permease component
HT135_18085	COG1175	transmembrane transport
HT135_18090	COG2182	Extracellular solute-binding protein
HT135_18095	COG1609	Transcriptional regulator
HT135_18100	COG2186	Transcriptional regulator
HT135_18105	COG1620	l-lactate permease
HT135_18110	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HT135_18120	COG5039	Polysaccharide pyruvyl transferase
HT135_18125	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HT135_18130	COG0110	maltose O-acetyltransferase activity
HT135_18135	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HT135_18140	COG2244	polysaccharide biosynthetic process
HT135_18145	COG1216	Glycosyl transferase, family 2
HT135_18150	COG5039	Polysaccharide pyruvyl transferase
HT135_18155	COG1216	Glycosyl transferase, family 2
HT135_18165	COG0438	transferase activity, transferring glycosyl groups
HT135_18170	COG1215	transferase activity, transferring glycosyl groups
HT135_18175	COG0438	transferase activity, transferring glycosyl groups
HT135_18180	COG1086	Polysaccharide biosynthesis protein
HT135_18185	COG0489	protein tyrosine kinase activity
HT135_18190	COG3944	biosynthesis protein
HT135_18195	COG1396	sequence-specific DNA binding
HT135_18200	COG2272	Belongs to the type-B carboxylesterase lipase family
HT135_18210	COG3479	Phenolic acid decarboxylase
HT135_18220	COG1794	racemase activity, acting on amino acids and derivatives
HT135_18225	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HT135_18235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HT135_18240	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HT135_18245	COG0640	Transcriptional regulator
HT135_18250	COG1621	beta-fructofuranosidase activity
HT135_18255	COG1621	beta-fructofuranosidase activity
HT135_18260	COG0531	amino acid
HT135_18265	COG1309	transcriptional regulator
HT135_18270	COG2076	Multidrug Resistance protein
HT135_18275	COG2076	Multidrug Resistance protein
HT135_18290	COG0277	FAD linked oxidase domain protein
HT135_18295	COG3621	Patatin-like phospholipase
HT135_18310	COG1611	Belongs to the LOG family
HT135_18315	COG1694	Mazg nucleotide pyrophosphohydrolase
HT135_18320	COG0659	secondary active sulfate transmembrane transporter activity
HT135_18325	COG0288	reversible hydration of carbon dioxide
HT135_18330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HT135_18335	COG0577	efflux transmembrane transporter activity
HT135_18340	COG1136	(ABC) transporter
HT135_18345	COG5002	protein histidine kinase activity
HT135_18350	COG0745	RESPONSE REGULATOR receiver
HT135_18360	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HT135_18365	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT135_18370	COG1481	regulation of sporulation
HT135_18375	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HT135_18380	COG1660	Displays ATPase and GTPase activities
HT135_18385	COG1051	belongs to the nudix hydrolase family
HT135_18390	COG0492	ferredoxin-NADP+ reductase activity
HT135_18395	COG3883	PFAM NLP P60 protein
HT135_18395	COG0791	NLP P60 protein
HT135_18400	COG0457	Tetratricopeptide repeat
HT135_18405	COG1132	(ABC) transporter
HT135_18425	COG0140	phosphoribosyl-ATP diphosphatase activity
HT135_18425	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HT135_18430	COG0107	imidazoleglycerol-phosphate synthase activity
HT135_18435	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HT135_18440	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HT135_18445	COG0131	Imidazoleglycerol-phosphate dehydratase
HT135_18450	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HT135_18455	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HT135_18460	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HT135_18465	COG4990	cell redox homeostasis
HT135_18470	COG5297	Belongs to the glycosyl hydrolase family 6
HT135_18475	COG0110	maltose O-acetyltransferase activity
HT135_18480	COG0546	phosphoglycolate phosphatase activity
HT135_18485	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HT135_18490	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HT135_18495	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HT135_18500	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HT135_18505	COG0363	glucosamine-6-phosphate deaminase activity
HT135_18510	COG2188	Transcriptional regulator
HT135_18515	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HT135_18525	COG1846	Transcriptional regulator
HT135_18530	COG2814	Major facilitator Superfamily
HT135_18535	COG1950	PFAM Membrane protein of
HT135_18540	COG1983	PspC domain protein
HT135_18545	COG3595	metallopeptidase activity
HT135_18560	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HT135_18570	COG4897	Protein conserved in bacteria
HT135_18575	COG0574	Belongs to the PEP-utilizing enzyme family
HT135_18575	COG3848	Pyruvate phosphate dikinase
HT135_18580	COG1309	transcriptional regulator
HT135_18585	COG2814	Major facilitator Superfamily
HT135_18590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HT135_18600	COG3409	Peptidoglycan-binding domain 1 protein
HT135_18600	COG0793	Belongs to the peptidase S41A family
HT135_18605	COG2177	Part of the ABC transporter FtsEX involved in
HT135_18610	COG2884	Cell division ATP-binding protein ftsE
HT135_18615	COG2010	Cytochrome c
HT135_18620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HT135_18630	COG0653	protein targeting
HT135_18635	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HT135_18650	COG1516	flagellar protein fliS
HT135_18655	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HT135_18660	COG1334	flagellar protein FlaG
HT135_18665	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HT135_18670	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HT135_18675	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HT135_18685	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HT135_18690	COG1256	bacterial-type flagellum assembly
HT135_18690	COG4786	Flagellar basal body rod
HT135_18695	COG3418	PFAM FlgN family protein
HT135_18700	COG2747	anti-sigma28 factor FlgM
HT135_18710	COG1040	competence protein
HT135_18720	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HT135_18725	COG1307	EDD domain protein, DegV family
HT135_18730	COG2197	response regulator
HT135_18735	COG4585	Histidine kinase
HT135_18740	COG1739	Uncharacterized protein family UPF0029
HT135_18745	COG1316	TRANSCRIPTIONal
HT135_18750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HT135_18755	COG0438	transferase activity, transferring glycosyl groups
HT135_18760	COG1215	transferase activity, transferring glycosyl groups
HT135_18765	COG3206	protein involved in exopolysaccharide biosynthesis
HT135_18770	COG3307	-O-antigen
HT135_18775	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HT135_18780	COG0438	transferase activity, transferring glycosyl groups
HT135_18780	COG0297	glycogen (starch) synthase activity
HT135_18785	COG2244	polysaccharide biosynthetic process
HT135_18795	COG0860	N-Acetylmuramoyl-L-alanine amidase
HT135_18795	COG2247	cell wall binding repeat
HT135_18800	COG2385	sporulation resulting in formation of a cellular spore
HT135_18800	COG2247	cell wall binding repeat
HT135_18810	COG1316	TRANSCRIPTIONal
HT135_18815	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HT135_18830	COG0438	transferase activity, transferring glycosyl groups
HT135_18835	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HT135_18840	COG1134	teichoic acid transport
HT135_18845	COG1682	transport, permease protein
HT135_18865	COG0463	Glycosyl transferase, family 2
HT135_18910	COG4193	domain, Protein
HT135_18915	COG1482	cell wall glycoprotein biosynthetic process
HT135_18920	COG0697	spore germination
HT135_18925	COG0814	amino acid
HT135_18935	COG2814	Major facilitator Superfamily
HT135_18940	COG1316	TRANSCRIPTIONal
HT135_18945	COG0561	phosphatase activity
HT135_18950	COG0791	NLP P60 protein
HT135_18960	COG2843	Capsule synthesis protein
HT135_18970	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HT135_18975	COG1609	Transcriptional regulator
HT135_18980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HT135_18985	COG1869	D-ribose catabolic process
HT135_18990	COG1129	ABC transporter
HT135_18995	COG1172	Belongs to the binding-protein-dependent transport system permease family
HT135_19000	COG1879	ABC-type sugar transport system periplasmic component
HT135_19005	COG3103	Sh3 type 3 domain protein
HT135_19015	COG2249	NAD(P)H dehydrogenase (quinone) activity
HT135_19020	COG3527	Alpha-acetolactate decarboxylase
HT135_19025	COG0028	Belongs to the TPP enzyme family
HT135_19030	COG0583	DNA-binding transcription factor activity
HT135_19035	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HT135_19050	COG5337	Spore coat protein CotH
HT135_19060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HT135_19065	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT135_19080	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HT135_19090	COG0405	Gamma-glutamyltransferase
HT135_19095	COG1522	sequence-specific DNA binding
HT135_19100	COG2059	Chromate
HT135_19105	COG2059	Chromate
HT135_19115	COG0655	NAD(P)H dehydrogenase (quinone) activity
HT135_19120	COG0583	DNA-binding transcription factor activity
HT135_19155	COG5444	nuclease activity
HT135_19180	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HT135_19185	COG4464	protein tyrosine phosphatase activity
HT135_19190	COG0489	protein tyrosine kinase activity
HT135_19195	COG3944	biosynthesis protein
HT135_19205	COG4715	Zinc finger, swim domain protein
HT135_19210	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HT135_19215	COG0561	phosphatase activity
HT135_19220	COG1349	DNA-binding transcription factor activity
HT135_19225	COG0629	single-stranded DNA binding
HT135_19240	COG2602	Beta-lactamase
HT135_19245	COG1970	mechanosensitive ion channel activity
HT135_19250	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HT135_19255	COG0457	Tetratricopeptide repeat
HT135_19260	COG4786	Flagellar basal body rod
HT135_19265	COG4786	Flagellar basal body rod
HT135_19270	COG1077	Cell shape determining protein MreB Mrl
HT135_19275	COG1609	Transcriptional regulator
HT135_19285	COG1846	Transcriptional regulator
HT135_19290	COG2814	Major facilitator Superfamily
HT135_19295	COG3420	alginic acid biosynthetic process
HT135_19300	COG1953	Uracil, thiamine, allantoin
HT135_19305	COG0477	Major facilitator Superfamily
HT135_19310	COG1335	isochorismatase
HT135_19320	COG0004	ammonium transporteR
HT135_19325	COG0347	Belongs to the P(II) protein family
HT135_19330	COG0671	phosphoesterase, PA-phosphatase related
HT135_19340	COG0739	heme binding
HT135_19345	COG1247	-acetyltransferase
HT135_19360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HT135_19370	COG2910	NAD(P)H-binding
HT135_19375	COG1959	2 iron, 2 sulfur cluster binding
HT135_19380	COG0804	urea catabolic process
HT135_19385	COG0832	Belongs to the urease beta subunit family
HT135_19390	COG0831	urea catabolic process
HT135_19420	COG3237	CsbD-like
HT135_19425	COG1994	Peptidase M50
HT135_19430	COG0457	Tetratricopeptide repeat
HT135_19435	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HT135_19440	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HT135_19450	COG2304	oxidoreductase activity
HT135_19455	COG2304	oxidoreductase activity
HT135_19460	COG2385	sporulation resulting in formation of a cellular spore
HT135_19465	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HT135_19475	COG4836	Membrane
HT135_19485	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HT135_19490	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HT135_19495	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HT135_19505	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HT135_19510	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HT135_19520	COG0356	it plays a direct role in the translocation of protons across the membrane
HT135_19530	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HT135_19535	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HT135_19540	COG4475	Protein of unknown function (DUF436)
HT135_19545	COG0698	ribose 5-phosphate isomerase
HT135_19550	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HT135_19555	COG1971	Probably functions as a manganese efflux pump
HT135_19560	COG0009	L-threonylcarbamoyladenylate synthase
HT135_19565	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HT135_19585	COG2890	protein-(glutamine-N5) methyltransferase activity
HT135_19590	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HT135_19595	COG0346	lactoylglutathione lyase activity
HT135_19600	COG0789	Transcriptional regulator
HT135_19605	COG0679	Auxin Efflux Carrier
HT135_19610	COG0281	malic enzyme
HT135_19615	COG1435	thymidine kinase activity
HT135_19625	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HT135_19635	COG1494	fructose-1,6-bisphosphatase
HT135_19640	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HT135_19645	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HT135_19650	COG0191	fructose-bisphosphate aldolase activity
HT135_19655	COG2204	response regulator
HT135_19660	COG4821	SIS domain
HT135_19665	COG0504	CTP synthase activity
HT135_19670	COG3343	RNA polymerase activity
HT135_19675	COG1960	acyl-CoA dehydrogenase activity
HT135_19680	COG0247	lactate metabolic process
HT135_19680	COG2181	nitrate reductase activity
HT135_19685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HT135_19690	COG4294	response to UV
HT135_19700	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HT135_19705	COG1132	(ABC) transporter
HT135_19710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HT135_19720	COG2181	nitrate reductase activity
HT135_19725	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HT135_19730	COG1140	nitrate reductase beta subunit
HT135_19735	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HT135_19740	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HT135_19750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HT135_19755	COG2223	nitrite transmembrane transporter activity
HT135_19760	COG0018	arginyl-trna synthetase
HT135_19765	COG4506	Protein conserved in bacteria
HT135_19775	COG0535	radical SAM domain protein
HT135_19785	COG1131	(ABC) transporter
HT135_19795	COG0612	Peptidase, M16
HT135_19815	COG3391	amine dehydrogenase activity
HT135_19820	COG0457	Tetratricopeptide repeat
HT135_19830	COG0010	Belongs to the arginase family
HT135_19835	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HT135_19840	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HT135_19855	COG1994	Peptidase M50
HT135_19860	COG1942	4-Oxalocrotonate Tautomerase
HT135_19865	COG1846	Transcriptional regulator
HT135_19870	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HT135_19875	COG0477	Major facilitator Superfamily
HT135_19880	COG1959	2 iron, 2 sulfur cluster binding
HT135_19885	COG3465	dGTPase activity
HT135_19890	COG1078	dGTPase activity
HT135_19895	COG4844	belongs to the
HT135_19905	COG0697	spore germination
HT135_19910	COG0095	Lipoate-protein ligase
HT135_19915	COG0583	DNA-binding transcription factor activity
HT135_19920	COG0280	phosphate acetyltransferase
HT135_19930	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_19935	COG0436	Aminotransferase
HT135_19940	COG2814	Major facilitator Superfamily
HT135_19945	COG0151	Belongs to the GarS family
HT135_19950	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_19955	COG1917	Cupin 2, conserved barrel domain protein
HT135_19960	COG0077	Prephenate dehydratase
HT135_19965	COG2814	Major facilitator Superfamily
HT135_19975	COG0833	amino acid
HT135_19980	COG4187	Peptidase family M20/M25/M40
HT135_19985	COG1012	belongs to the aldehyde dehydrogenase family
HT135_19990	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HT135_20000	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HT135_20005	COG1091	dTDP-4-dehydrorhamnose reductase activity
HT135_20010	COG1088	dTDP-glucose 4,6-dehydratase activity
HT135_20015	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HT135_20020	COG3980	spore coat polysaccharide biosynthesis protein
HT135_20025	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HT135_20030	COG2089	acid synthase
HT135_20035	COG0456	acetyltransferase
HT135_20040	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HT135_20045	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HT135_20050	COG0463	Glycosyl transferase, family 2
HT135_20060	COG2363	Small membrane protein
HT135_20065	COG2233	PERMEase
HT135_20075	COG1012	belongs to the aldehyde dehydrogenase family
HT135_20080	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HT135_20085	COG1216	Glycosyl transferase, family 2
HT135_20100	COG1695	Transcriptional regulator
HT135_20105	COG0351	phosphomethylpyrimidine kinase
HT135_20115	COG1621	beta-fructofuranosidase activity
HT135_20120	COG1263	PTS System
HT135_20120	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT135_20125	COG2116	formate transmembrane transporter activity
HT135_20130	COG3711	transcriptional antiterminator
HT135_20140	COG1404	Belongs to the peptidase S8 family
HT135_20145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HT135_20150	COG0778	Nitroreductase
HT135_20155	COG0772	Belongs to the SEDS family
HT135_20175	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HT135_20180	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HT135_20185	COG2261	transglycosylase associated protein
HT135_20190	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HT135_20195	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HT135_20200	COG2246	polysaccharide biosynthetic process
HT135_20205	COG1309	transcriptional regulator
HT135_20215	COG3162	membrane
HT135_20220	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HT135_20225	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HT135_20230	COG2837	iron assimilation
HT135_20235	COG2822	iron ion transport
HT135_20240	COG0672	)-iron permease
HT135_20245	COG0352	thiamine-phosphate diphosphorylase activity
HT135_20250	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HT135_20255	COG0583	DNA-binding transcription factor activity
HT135_20260	COG1380	Effector of murein hydrolase LrgA
HT135_20265	COG1346	cytolysis
HT135_20270	COG2814	Major facilitator Superfamily
HT135_20275	COG4895	conserved protein (DUF2196)
HT135_20280	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HT135_20285	COG0346	lactoylglutathione lyase activity
HT135_20295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HT135_20300	COG1404	Belongs to the peptidase S8 family
HT135_20305	COG1263	PTS System
HT135_20305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT135_20310	COG3711	transcriptional antiterminator
HT135_20315	COG1442	glycosyl transferase family 8
HT135_20320	COG5522	Integral membrane protein (intg_mem_TP0381)
HT135_20325	COG1846	Transcriptional regulator
HT135_20330	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HT135_20335	COG2234	aminopeptidase activity
HT135_20340	COG2357	RelA SpoT domain protein
HT135_20345	COG1575	Belongs to the MenA family. Type 1 subfamily
HT135_20355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HT135_20360	COG1696	Membrane protein involved in D-alanine export
HT135_20365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HT135_20370	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HT135_20375	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HT135_20380	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HT135_20385	COG1486	melibiose metabolic process
HT135_20390	COG1447	Phosphotransferase system cellobiose-specific component IIA
HT135_20395	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HT135_20400	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HT135_20405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HT135_20405	COG3711	transcriptional antiterminator
HT135_20415	COG2094	Belongs to the DNA glycosylase MPG family
HT135_20420	COG0753	catalase activity
HT135_20425	COG2814	Major facilitator Superfamily
HT135_20430	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HT135_20435	COG1131	(ABC) transporter
HT135_20455	COG1595	DNA-templated transcription, initiation
HT135_20460	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HT135_20465	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HT135_20470	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HT135_20475	COG4988	ABC transporter
HT135_20480	COG1294	oxidase, subunit
HT135_20485	COG1271	oxidase subunit
HT135_20490	COG3493	citrate carrier protein
HT135_20495	COG0501	Belongs to the peptidase M48B family
HT135_20505	COG0726	polysaccharide deacetylase
HT135_20515	COG3842	ATPase activity
HT135_20520	COG2508	Transcriptional regulator
HT135_20525	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HT135_20535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HT135_20545	COG2195	Cleaves the N-terminal amino acid of tripeptides
HT135_20560	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HT135_20565	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HT135_20570	COG3829	transcription factor binding
HT135_20570	COG3290	protein histidine kinase activity
HT135_20575	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_20580	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HT135_20585	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HT135_20590	COG2610	gluconate transmembrane transporter activity
HT135_20595	COG0500	methyltransferase
HT135_20600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HT135_20615	COG0693	protein deglycase activity
HT135_20615	COG0753	catalase activity
HT135_20620	COG2851	Citrate transporter
HT135_20630	COG2723	6-phospho-beta-galactosidase activity
HT135_20635	COG2190	(PTS) system
HT135_20635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT135_20635	COG1263	PTS System
HT135_20640	COG3711	transcriptional antiterminator
HT135_20650	COG2270	Major facilitator Superfamily
HT135_20655	COG0513	Belongs to the DEAD box helicase family
HT135_20660	COG3401	FG-GAP repeat protein
HT135_20660	COG2755	lipolytic protein G-D-S-L family
HT135_20715	COG0697	spore germination
HT135_20720	COG0589	response to stress
HT135_20725	COG2723	6-phospho-beta-galactosidase activity
HT135_20730	COG1263	PTS System
HT135_20730	COG2190	(PTS) system
HT135_20730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HT135_20750	COG5444	nuclease activity
HT135_20785	COG3507	Belongs to the glycosyl hydrolase 43 family
HT135_20800	COG2986	histidine ammonia-lyase
HT135_20805	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HT135_20810	COG1228	amidohydrolase
HT135_20815	COG0010	Belongs to the arginase family
HT135_20820	COG0833	amino acid
HT135_20825	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HT135_20830	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HT135_20835	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HT135_20840	COG2390	Transcriptional regulator
HT135_20850	COG3192	ethanolamine utilization protein
HT135_20855	COG2079	MmgE PrpD family protein
HT135_20860	COG1473	amidohydrolase
HT135_20865	COG1126	abc transporter atp-binding protein
HT135_20870	COG0765	amino acid transport
HT135_20875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HT135_20880	COG0456	acetyltransferase
HT135_20885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HT135_20895	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HT135_20900	COG0561	phosphatase activity
HT135_20930	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HT135_20935	COG5294	Protein conserved in bacteria
HT135_20940	COG0577	efflux transmembrane transporter activity
HT135_20945	COG1136	(ABC) transporter
HT135_20950	COG2205	protein histidine kinase activity
HT135_20955	COG0745	RESPONSE REGULATOR receiver
HT135_20960	COG0191	fructose-bisphosphate aldolase activity
HT135_20970	COG1082	Xylose isomerase domain protein TIM barrel
HT135_20975	COG0673	inositol 2-dehydrogenase activity
HT135_20980	COG2814	Major facilitator Superfamily
HT135_20985	COG1082	Xylose isomerase domain protein TIM barrel
HT135_20990	COG3962	Belongs to the TPP enzyme family
HT135_20995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HT135_21005	COG1012	belongs to the aldehyde dehydrogenase family
HT135_21010	COG1349	DNA-binding transcription factor activity
HT135_21015	COG0667	Aldo Keto reductase
HT135_21040	COG2814	Major facilitator Superfamily
HT135_21045	COG0326	Molecular chaperone. Has ATPase activity
HT135_21055	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_21060	COG1309	transcriptional regulator
HT135_21065	COG1012	belongs to the aldehyde dehydrogenase family
HT135_21070	COG1714	RDD family
HT135_21075	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HT135_21085	COG1714	RDD family
HT135_21090	COG2311	Membrane
HT135_21095	COG1917	Cupin 2, conserved barrel domain protein
HT135_21100	COG1309	transcriptional regulator
HT135_21105	COG1028	Short-chain dehydrogenase reductase Sdr
HT135_21110	COG1846	Transcriptional regulator
HT135_21115	COG1380	Effector of murein hydrolase LrgA
HT135_21120	COG1346	cytolysis
HT135_21145	COG5039	Polysaccharide pyruvyl transferase
HT135_21150	COG1929	Belongs to the glycerate kinase type-1 family
HT135_21155	COG1802	Transcriptional regulator
HT135_21160	COG1070	Carbohydrate kinase
HT135_21165	COG2610	gluconate transmembrane transporter activity
HT135_21170	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HT135_21175	COG0450	alkyl hydroperoxide reductase
HT135_21180	COG3634	alkyl hydroperoxide reductase activity
HT135_21185	COG2723	6-phospho-beta-galactosidase activity
HT135_21195	COG2188	Transcriptional regulator
HT135_21205	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HT135_21240	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HT135_21255	COG1063	alcohol dehydrogenase
HT135_21275	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HT135_21280	COG0456	acetyltransferase
HT135_21285	COG0457	Tetratricopeptide repeat
HT135_21295	COG0010	Belongs to the arginase family
HT135_21300	COG0833	amino acid
HT135_21305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HT135_21310	COG3829	transcription factor binding
HT135_21315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HT135_21320	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HT135_21325	COG4853	Protein conserved in bacteria
HT135_21330	COG4863	YycH protein
HT135_21335	COG5002	protein histidine kinase activity
HT135_21340	COG0745	RESPONSE REGULATOR receiver
HT135_21370	COG0346	lactoylglutathione lyase activity
HT135_21375	COG0305	Participates in initiation and elongation during chromosome replication
HT135_21390	COG3093	addiction module antidote protein HigA
HT135_21395	COG2807	transmembrane transport
HT135_21400	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HT135_21405	COG0359	binds to the 23S rRNA
HT135_21410	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HT135_21415	COG4241	membrane
HT135_21425	COG5577	PFAM Coat F domain
HT135_21430	COG1733	regulation of RNA biosynthetic process
HT135_21435	COG1227	inorganic diphosphatase activity
HT135_21445	COG2271	Major facilitator Superfamily
HT135_21460	COG4319	ketosteroid isomerase
HT135_21470	COG2814	Major facilitator Superfamily
HT135_21475	COG0583	DNA-binding transcription factor activity
HT135_21480	COG2153	protein acetylation
HT135_21490	COG0583	DNA-binding transcription factor activity
HT135_21505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HT135_21515	COG0640	Transcriptional regulator
HT135_21520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HT135_21545	COG0300	oxidoreductase activity
HT135_21555	COG1902	pentaerythritol trinitrate reductase activity
HT135_21565	COG1309	transcriptional regulator
HT135_21575	COG1063	alcohol dehydrogenase
HT135_21585	COG0789	Transcriptional regulator
HT135_21585	COG4978	Transcriptional regulator
HT135_21590	COG1811	Na channel or pump
HT135_21595	COG2207	Transcriptional regulator
HT135_21595	COG3708	Transcriptional regulator
HT135_21615	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HT135_21620	COG1331	Highly conserved protein containing a thioredoxin domain
HT135_21640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HT135_21645	COG2856	Zn peptidase
HT135_21680	COG1331	Highly conserved protein containing a thioredoxin domain
HT135_21685	COG1266	CAAX protease self-immunity
HT135_21690	COG0477	Major facilitator Superfamily
HT135_21690	COG2814	Major facilitator Superfamily
HT135_21695	COG0110	maltose O-acetyltransferase activity
HT135_21700	COG0346	lactoylglutathione lyase activity
HT135_21705	COG1609	Transcriptional regulator
HT135_21710	COG0708	Exodeoxyribonuclease III
HT135_21720	COG0629	single-stranded DNA binding
HT135_21725	COG0360	Binds together with S18 to 16S ribosomal RNA
HT135_21730	COG0012	GTP binding
HT135_21735	COG0243	molybdopterin cofactor binding
HT135_21740	COG4481	Protein conserved in bacteria
HT135_21745	COG3949	Membrane
HT135_21755	COG1475	DNA binding
HT135_21760	COG1192	Involved in chromosome partitioning
HT135_21770	COG1475	DNA binding
HT135_21775	COG0357	Ribosomal RNA small subunit methyltransferase G
HT135_21780	COG0445	tRNA wobble uridine modification
HT135_21785	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HT135_21790	COG1847	R3H domain protein
HT135_21795	COG0706	membrane insertase activity
HT135_21800	COG0594	ribonuclease P activity