locus-tag	class	description
NLK52_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NLK52_00010	COG0592	DNA-directed DNA polymerase activity
NLK52_00015	COG2501	S4 domain
NLK52_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NLK52_00030	COG0187	DNA topoisomerase II activity
NLK52_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NLK52_00070	COG0516	GMP reductase activity
NLK52_00070	COG0517	IMP dehydrogenase activity
NLK52_00075	COG1686	Belongs to the peptidase S11 family
NLK52_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NLK52_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NLK52_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NLK52_00100	COG1428	Deoxynucleoside kinase
NLK52_00105	COG1428	Deoxynucleoside kinase
NLK52_00110	COG1388	LysM domain
NLK52_00110	COG3858	chitin binding
NLK52_00115	COG1335	isochorismatase
NLK52_00120	COG0590	tRNA wobble adenosine to inosine editing
NLK52_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NLK52_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NLK52_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NLK52_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
NLK52_00190	COG3853	Toxic anion resistance protein (TelA)
NLK52_00195	COG1982	Orn Lys Arg decarboxylase major
NLK52_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NLK52_00205	COG3870	Protein conserved in bacteria
NLK52_00210	COG1728	Protein conserved in bacteria
NLK52_00215	COG0470	DNA polymerase III
NLK52_00220	COG1774	PSP1 C-terminal conserved region
NLK52_00225	COG4467	Involved in initiation control of chromosome replication
NLK52_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NLK52_00235	COG2827	Endonuclease containing a URI domain
NLK52_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NLK52_00245	COG2002	toxin-antitoxin pair type II binding
NLK52_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NLK52_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NLK52_00255	COG0084	hydrolase, TatD family'
NLK52_00260	COG3583	domain protein
NLK52_00260	COG3584	3D domain protein
NLK52_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NLK52_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NLK52_00280	COG4466	Protein conserved in bacteria
NLK52_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NLK52_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NLK52_00300	COG0251	oxidation-reduction process
NLK52_00305	COG2088	sporulation resulting in formation of a cellular spore
NLK52_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NLK52_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NLK52_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NLK52_00325	COG0193	aminoacyl-tRNA hydrolase activity
NLK52_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NLK52_00340	COG2002	toxin-antitoxin pair type II binding
NLK52_00345	COG2244	polysaccharide biosynthetic process
NLK52_00350	COG3956	TIGRFAM MazG family protein
NLK52_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NLK52_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NLK52_00375	COG1098	S1 RNA binding domain
NLK52_00390	COG2208	phosphoserine phosphatase activity
NLK52_00395	COG2304	oxidoreductase activity
NLK52_00400	COG0515	serine threonine protein kinase
NLK52_00405	COG0037	tRNA processing
NLK52_00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NLK52_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NLK52_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NLK52_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NLK52_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NLK52_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NLK52_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NLK52_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
NLK52_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NLK52_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NLK52_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NLK52_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NLK52_00470	COG1396	sequence-specific DNA binding
NLK52_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NLK52_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NLK52_00560	COG4463	regulation of RNA biosynthetic process
NLK52_00565	COG3880	PFAM UvrB UvrC protein
NLK52_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
NLK52_00575	COG0542	response to heat
NLK52_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NLK52_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NLK52_00590	COG4956	integral membrane protein (PIN domain superfamily)
NLK52_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NLK52_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NLK52_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NLK52_00610	COG1045	serine acetyltransferase
NLK52_00615	COG0215	cysteine-tRNA ligase activity
NLK52_00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
NLK52_00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NLK52_00630	COG3688	RNA-binding protein containing a PIN domain
NLK52_00635	COG1595	DNA-templated transcription, initiation
NLK52_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NLK52_00650	COG0250	Participates in transcription elongation, termination and antitermination
NLK52_00660	COG0081	regulation of translation
NLK52_00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NLK52_00675	COG2813	Specifically methylates the guanine in position
NLK52_00680	COG0085	RNA polymerase activity
NLK52_00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NLK52_00690	COG1358	cellular component organization or biogenesis
NLK52_00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NLK52_00700	COG0049	tRNA binding
NLK52_00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NLK52_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NLK52_00715	COG0596	Alpha beta hydrolase
NLK52_00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NLK52_00730	COG0088	Forms part of the polypeptide exit tunnel
NLK52_00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NLK52_00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NLK52_00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NLK52_00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NLK52_00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NLK52_00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NLK52_00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NLK52_00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NLK52_00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NLK52_00820	COG0200	Binds to the 23S rRNA
NLK52_00825	COG0201	protein transport
NLK52_00830	COG0563	adenylate kinase activity
NLK52_00835	COG0024	Methionine aminopeptidase
NLK52_00845	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NLK52_00850	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NLK52_00855	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NLK52_00860	COG0202	RNA polymerase activity
NLK52_00865	COG0203	ribosomal protein L17
NLK52_00870	COG1122	ATPase activity
NLK52_00875	COG1122	ATPase activity
NLK52_00880	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NLK52_00885	COG0101	tRNA pseudouridine synthase activity
NLK52_00890	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NLK52_00895	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NLK52_00900	COG2226	methyltransferase
NLK52_00910	COG0860	N-Acetylmuramoyl-L-alanine amidase
NLK52_00915	COG0489	protein tyrosine kinase activity
NLK52_00925	COG2194	sulfuric ester hydrolase activity
NLK52_00930	COG0726	polysaccharide deacetylase
NLK52_01010	COG0659	secondary active sulfate transmembrane transporter activity
NLK52_01015	COG0385	Bile acid
NLK52_01020	COG2819	hydrolase of the alpha beta superfamily
NLK52_01025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NLK52_01030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NLK52_01035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NLK52_01040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NLK52_01040	COG2207	Transcriptional regulator
NLK52_01045	COG3876	Protein conserved in bacteria
NLK52_01050	COG1472	Belongs to the glycosyl hydrolase 3 family
NLK52_01055	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NLK52_01060	COG1263	PTS System
NLK52_01060	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NLK52_01065	COG1737	Transcriptional regulator
NLK52_01070	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NLK52_01075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NLK52_01080	COG1683	Conserved Protein
NLK52_01110	COG1595	DNA-templated transcription, initiation
NLK52_01115	COG5662	AntiSigma factor
NLK52_01120	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NLK52_01125	COG4856	YbbR-like protein
NLK52_01130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NLK52_01135	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NLK52_01145	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NLK52_01150	COG3002	Belongs to the UPF0753 family
NLK52_01155	COG0288	reversible hydration of carbon dioxide
NLK52_01165	COG5609	conserved protein (DUF2294)
NLK52_01170	COG0640	Transcriptional regulator
NLK52_01175	COG2814	Major facilitator Superfamily
NLK52_01190	COG0596	Alpha beta hydrolase
NLK52_01195	COG0745	RESPONSE REGULATOR receiver
NLK52_01200	COG0642	Histidine kinase
NLK52_01210	COG0515	serine threonine protein kinase
NLK52_01225	COG1113	amino acid transport
NLK52_01240	COG2602	Beta-lactamase
NLK52_01245	COG2124	cytochrome p450
NLK52_01255	COG0531	amino acid
NLK52_01260	COG0584	glycerophosphoryl diester phosphodiesterase
NLK52_01265	COG2271	Major facilitator Superfamily
NLK52_01275	COG0456	acetyltransferase
NLK52_01275	COG1846	Transcriptional regulator
NLK52_01280	COG2271	Major facilitator Superfamily
NLK52_01290	COG0697	spore germination
NLK52_01295	COG1917	Cupin 2, conserved barrel domain protein
NLK52_01295	COG2207	Transcriptional regulator
NLK52_01300	COG1397	ADP-ribosylglycohydrolase
NLK52_01305	COG5444	nuclease activity
NLK52_01310	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NLK52_01315	COG3591	Belongs to the peptidase S1B family
NLK52_01325	COG0596	Alpha beta hydrolase
NLK52_01330	COG1183	phosphatidylcholine synthase activity
NLK52_01335	COG0586	Pfam SNARE associated Golgi protein
NLK52_01340	COG0688	phosphatidylethanolamine metabolic process
NLK52_01350	COG2312	Erythromycin esterase
NLK52_01355	COG1054	Belongs to the UPF0176 family
NLK52_01360	COG1301	dicarboxylic acid transport
NLK52_01365	COG1263	PTS System
NLK52_01365	COG2190	(PTS) system
NLK52_01365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NLK52_01370	COG0363	glucosamine-6-phosphate deaminase activity
NLK52_01375	COG2188	Transcriptional regulator
NLK52_01385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NLK52_01390	COG0833	amino acid
NLK52_01395	COG2040	homocysteine
NLK52_01400	COG1115	amino acid carrier protein
NLK52_01405	COG2066	Belongs to the glutaminase family
NLK52_01410	COG4191	Histidine kinase
NLK52_01415	COG0784	Response regulator, receiver
NLK52_01420	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NLK52_01425	COG1012	belongs to the aldehyde dehydrogenase family
NLK52_01430	COG2271	Major facilitator Superfamily
NLK52_01435	COG4948	Mandelate Racemase Muconate Lactonizing
NLK52_01440	COG2186	Transcriptional regulator
NLK52_01445	COG2721	sulfolactate sulfo-lyase activity
NLK52_01450	COG3173	Aminoglycoside phosphotransferase
NLK52_01460	COG0697	spore germination
NLK52_01465	COG0745	RESPONSE REGULATOR receiver
NLK52_01470	COG2205	protein histidine kinase activity
NLK52_01475	COG1131	(ABC) transporter
NLK52_01495	COG3773	Cell wall hydrolase
NLK52_01500	COG2304	oxidoreductase activity
NLK52_01510	COG3540	Alkaline phosphatase
NLK52_01515	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NLK52_01520	COG0805	protein transport
NLK52_01525	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
NLK52_01530	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NLK52_01535	COG0477	Major facilitator Superfamily
NLK52_01540	COG1309	transcriptional regulator
NLK52_01545	COG0252	asparaginase activity
NLK52_01550	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NLK52_01555	COG1714	RDD family
NLK52_01560	COG3012	SEC-C Motif Domain Protein
NLK52_01560	COG1405	negative regulation of cell septum assembly
NLK52_01565	COG3290	protein histidine kinase activity
NLK52_01570	COG3279	Response regulator of the LytR AlgR family
NLK52_01575	COG4555	ABC transporter
NLK52_01580	COG1668	transmembrane transport
NLK52_01585	COG0667	Aldo Keto reductase
NLK52_01600	COG1595	DNA-templated transcription, initiation
NLK52_01605	COG1595	DNA-templated transcription, initiation
NLK52_01610	COG1876	peptidase activity
NLK52_01615	COG0457	Tetratricopeptide repeat
NLK52_01620	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_01625	COG0366	Alpha amylase catalytic
NLK52_01630	COG0803	Belongs to the bacterial solute-binding protein 9 family
NLK52_01635	COG1121	(ABC) transporter
NLK52_01640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NLK52_01645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NLK52_01650	COG2310	stress, protein
NLK52_01655	COG2310	stress, protein
NLK52_01660	COG2310	stress, protein
NLK52_01665	COG0861	Integral membrane protein TerC family
NLK52_01675	COG3853	Toxic anion resistance protein (TelA)
NLK52_01680	COG0477	Major facilitator Superfamily
NLK52_01685	COG2814	Major facilitator Superfamily
NLK52_01690	COG0640	Transcriptional regulator
NLK52_01695	COG4175	Glycine betaine
NLK52_01695	COG0517	IMP dehydrogenase activity
NLK52_01700	COG4176	ABC-type proline glycine betaine transport system permease component
NLK52_01705	COG2113	Glycine betaine
NLK52_01715	COG1288	antiporter activity
NLK52_01725	COG0366	Alpha amylase catalytic
NLK52_01730	COG0039	L-malate dehydrogenase activity
NLK52_01735	COG1620	l-lactate permease
NLK52_01740	COG2814	Major facilitator Superfamily
NLK52_01745	COG1846	Transcriptional regulator
NLK52_01750	COG1280	lysine exporter protein (LysE YggA)
NLK52_01755	COG3403	YqcI/YcgG family
NLK52_01760	COG1113	amino acid transport
NLK52_01765	COG3665	Urea carboxylase-associated protein
NLK52_01770	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NLK52_01775	COG1660	Displays ATPase and GTPase activities
NLK52_01780	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NLK52_01785	COG2226	methyltransferase
NLK52_01790	COG0583	DNA-binding transcription factor activity
NLK52_01795	COG3458	cephalosporin-C deacetylase activity
NLK52_01800	COG3541	Predicted nucleotidyltransferase
NLK52_01805	COG0506	proline dehydrogenase activity
NLK52_01810	COG1012	belongs to the aldehyde dehydrogenase family
NLK52_01815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NLK52_01820	COG2508	Transcriptional regulator
NLK52_01825	COG3689	TIGRFAM TIGR03943 family protein
NLK52_01830	COG0701	Predicted permease
NLK52_01835	COG2267	carboxylic ester hydrolase activity
NLK52_01840	COG0492	ferredoxin-NADP+ reductase activity
NLK52_01845	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NLK52_01845	COG1587	Uroporphyrinogen-III synthase
NLK52_01850	COG2146	nitrite reductase [NAD(P)H] activity
NLK52_01855	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NLK52_01860	COG0243	molybdopterin cofactor binding
NLK52_01865	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NLK52_01870	COG2223	nitrite transmembrane transporter activity
NLK52_01875	COG1469	GTP cyclohydrolase I activity
NLK52_01880	COG1376	ErfK ybiS ycfS ynhG family protein
NLK52_01890	COG0523	cobalamin synthesis protein
NLK52_01895	COG0765	amino acid transport
NLK52_01900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NLK52_01910	COG1714	RDD family
NLK52_01920	COG2723	6-phospho-beta-galactosidase activity
NLK52_01930	COG3209	COG3209 Rhs family protein
NLK52_01935	COG0840	transmembrane signaling receptor activity
NLK52_01935	COG3290	protein histidine kinase activity
NLK52_01940	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NLK52_01945	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
NLK52_01950	COG1733	regulation of RNA biosynthetic process
NLK52_01955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NLK52_01975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NLK52_01980	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NLK52_01985	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NLK52_01990	COG2814	Major facilitator Superfamily
NLK52_02000	COG0697	spore germination
NLK52_02005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NLK52_02015	COG2364	Membrane
NLK52_02020	COG1126	abc transporter atp-binding protein
NLK52_02025	COG0765	amino acid transport
NLK52_02030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NLK52_02035	COG0583	DNA-binding transcription factor activity
NLK52_02040	COG0163	prenyltransferase activity
NLK52_02045	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NLK52_02060	COG0596	Alpha beta hydrolase
NLK52_02065	COG3104	oligopeptide transport
NLK52_02070	COG5434	Belongs to the glycosyl hydrolase 28 family
NLK52_02080	COG0697	spore germination
NLK52_02090	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NLK52_02095	COG1136	(ABC) transporter
NLK52_02100	COG0577	efflux transmembrane transporter activity
NLK52_02105	COG0745	RESPONSE REGULATOR receiver
NLK52_02110	COG3850	Histidine kinase
NLK52_02110	COG5002	protein histidine kinase activity
NLK52_02115	COG0457	Tetratricopeptide repeat
NLK52_02135	COG0527	aspartate kinase activity
NLK52_02140	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NLK52_02145	COG4605	iron ion homeostasis
NLK52_02150	COG4604	ABC transporter, ATP-binding protein
NLK52_02155	COG4607	ABC-type enterochelin transport system periplasmic component
NLK52_02160	COG2814	Major facilitator Superfamily
NLK52_02165	COG1309	transcriptional regulator
NLK52_02170	COG0778	Nitroreductase
NLK52_02175	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NLK52_02180	COG0640	Transcriptional regulator
NLK52_02185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NLK52_02190	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NLK52_02195	COG1012	belongs to the aldehyde dehydrogenase family
NLK52_02200	COG4975	Glucose uptake
NLK52_02205	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_02210	COG4549	nuclear export factor GLE1
NLK52_02215	COG2372	response to copper ion
NLK52_02215	COG1276	copper resistance
NLK52_02220	COG1349	DNA-binding transcription factor activity
NLK52_02230	COG2213	PTS system mannitol-specific
NLK52_02235	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NLK52_02240	COG0246	Mannitol dehydrogenase
NLK52_02245	COG0473	3-isopropylmalate dehydrogenase activity
NLK52_02250	COG0681	Belongs to the peptidase S26 family
NLK52_02255	COG0412	Dienelactone hydrolase
NLK52_02260	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NLK52_02270	COG0561	phosphatase activity
NLK52_02275	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NLK52_02280	COG1914	H( )-stimulated, divalent metal cation uptake system
NLK52_02285	COG4336	lyase activity
NLK52_02290	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NLK52_02295	COG1984	allophanate hydrolase subunit 2
NLK52_02300	COG1414	Transcriptional regulator
NLK52_02305	COG2755	lipolytic protein G-D-S-L family
NLK52_02315	COG2329	Antibiotic biosynthesis monooxygenase
NLK52_02320	COG0768	penicillin binding
NLK52_02325	COG4989	oxidoreductase activity
NLK52_02330	COG3711	transcriptional antiterminator
NLK52_02335	COG0318	PFAM AMP-dependent synthetase and ligase
NLK52_02340	COG2226	methyltransferase
NLK52_02345	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_02350	COG1917	Cupin 2, conserved barrel domain protein
NLK52_02355	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NLK52_02360	COG3871	stress protein (general stress protein 26)
NLK52_02370	COG2814	Major facilitator Superfamily
NLK52_02375	COG1522	sequence-specific DNA binding
NLK52_02380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NLK52_02380	COG0551	DNA topoisomerase type I activity
NLK52_02385	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
NLK52_02390	COG3706	GGDEF domain
NLK52_02395	COG5298	Protein conserved in bacteria
NLK52_02400	COG1215	transferase activity, transferring glycosyl groups
NLK52_02410	COG0531	amino acid
NLK52_02415	COG0494	nUDIX hydrolase
NLK52_02420	COG0028	Belongs to the TPP enzyme family
NLK52_02435	COG1914	H( )-stimulated, divalent metal cation uptake system
NLK52_02440	COG2261	transglycosylase associated protein
NLK52_02445	COG4876	unkown
NLK52_02450	COG2217	Heavy metal translocating P-type atpase
NLK52_02455	COG3729	General stress protein
NLK52_02460	COG0662	Cupin 2, conserved barrel domain protein
NLK52_02465	COG2329	Antibiotic biosynthesis monooxygenase
NLK52_02470	COG3546	catalase activity
NLK52_02475	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NLK52_02480	COG3290	protein histidine kinase activity
NLK52_02485	COG4565	transcriptional regulatory protein
NLK52_02490	COG1301	dicarboxylic acid transport
NLK52_02495	COG0628	permease
NLK52_02500	COG1131	(ABC) transporter
NLK52_02505	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NLK52_02515	COG1960	acyl-CoA dehydrogenase activity
NLK52_02530	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NLK52_02535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NLK52_02540	COG1181	Belongs to the D-alanine--D-alanine ligase family
NLK52_02545	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NLK52_02550	COG0513	Belongs to the DEAD box helicase family
NLK52_02555	COG3402	PFAM membrane-flanked domain
NLK52_02560	COG3428	Bacterial PH domain
NLK52_02565	COG0705	Rhomboid family
NLK52_02570	COG0736	holo-[acyl-carrier-protein] synthase activity
NLK52_02575	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NLK52_02580	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NLK52_02585	COG0864	Transcriptional regulator
NLK52_02590	COG2337	Toxic component of a toxin-antitoxin (TA) module
NLK52_02595	COG1366	Belongs to the anti-sigma-factor antagonist family
NLK52_02600	COG1366	Belongs to the anti-sigma-factor antagonist family
NLK52_02605	COG2172	sigma factor antagonist activity
NLK52_02610	COG2208	phosphoserine phosphatase activity
NLK52_02615	COG1366	Belongs to the anti-sigma-factor antagonist family
NLK52_02620	COG2172	sigma factor antagonist activity
NLK52_02625	COG1191	sigma factor activity
NLK52_02630	COG2208	phosphoserine phosphatase activity
NLK52_02640	COG1673	EVE domain
NLK52_02645	COG1846	Transcriptional regulator
NLK52_02650	COG2183	response to ionizing radiation
NLK52_02660	COG3091	SprT-like family
NLK52_02710	COG0515	serine threonine protein kinase
NLK52_02740	COG0515	serine threonine protein kinase
NLK52_02745	COG1132	(ABC) transporter
NLK52_02765	COG1476	TRANSCRIPTIONal
NLK52_02775	COG3239	Fatty acid desaturase
NLK52_02780	COG1278	Cold shock
NLK52_02785	COG1329	Transcriptional regulator
NLK52_02790	COG1917	Cupin 2, conserved barrel domain protein
NLK52_02790	COG2207	Transcriptional regulator
NLK52_02795	COG0697	spore germination
NLK52_02800	COG3708	Transcriptional regulator
NLK52_02800	COG2207	Transcriptional regulator
NLK52_02805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NLK52_02810	COG0477	Major facilitator Superfamily
NLK52_02820	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
NLK52_02830	COG0697	spore germination
NLK52_02835	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NLK52_02840	COG2030	dehydratase
NLK52_02845	COG3545	Serine hydrolase
NLK52_02850	COG1733	regulation of RNA biosynthetic process
NLK52_02855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NLK52_02860	COG1733	regulation of RNA biosynthetic process
NLK52_02865	COG2249	NAD(P)H dehydrogenase (quinone) activity
NLK52_02870	COG2814	Major facilitator Superfamily
NLK52_02875	COG1309	transcriptional regulator
NLK52_02880	COG0640	Transcriptional regulator
NLK52_02885	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NLK52_02895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NLK52_02900	COG1316	TRANSCRIPTIONal
NLK52_02915	COG5002	protein histidine kinase activity
NLK52_02920	COG0745	RESPONSE REGULATOR receiver
NLK52_02925	COG0697	spore germination
NLK52_02930	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NLK52_02935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NLK52_02940	COG0640	Transcriptional regulator
NLK52_02945	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NLK52_02960	COG4585	Histidine kinase
NLK52_02965	COG2197	response regulator
NLK52_02970	COG2409	Drug exporters of the RND superfamily
NLK52_02975	COG0596	Alpha beta hydrolase
NLK52_02980	COG1811	Na channel or pump
NLK52_02985	COG4978	Transcriptional regulator
NLK52_02985	COG0789	Transcriptional regulator
NLK52_02990	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NLK52_02995	COG0778	Nitroreductase
NLK52_03000	COG0346	lactoylglutathione lyase activity
NLK52_03005	COG2259	Doxx family
NLK52_03010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NLK52_03030	COG2323	membrane
NLK52_03040	COG0071	Belongs to the small heat shock protein (HSP20) family
NLK52_03055	COG1309	transcriptional regulator
NLK52_03065	COG0456	acetyltransferase
NLK52_03075	COG2814	Major facilitator Superfamily
NLK52_03085	COG0488	(ABC) transporter
NLK52_03090	COG1113	amino acid transport
NLK52_03095	COG2318	DinB family
NLK52_03100	COG1846	Transcriptional regulator
NLK52_03105	COG1033	growth of symbiont in host cell
NLK52_03105	COG2409	Drug exporters of the RND superfamily
NLK52_03110	COG0778	Nitroreductase
NLK52_03115	COG1846	Transcriptional regulator
NLK52_03120	COG2814	Major facilitator Superfamily
NLK52_03125	COG0730	response to heat
NLK52_03130	COG1802	Transcriptional regulator
NLK52_03135	COG1388	LysM domain
NLK52_03135	COG3858	chitin binding
NLK52_03140	COG1819	glycosyl
NLK52_03150	COG1785	Belongs to the alkaline phosphatase family
NLK52_03155	COG5646	InterPro IPR014922
NLK52_03165	COG0454	-acetyltransferase
NLK52_03170	COG1078	dGTPase activity
NLK52_03175	COG1388	LysM domain
NLK52_03180	COG2814	Major facilitator Superfamily
NLK52_03185	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NLK52_03190	COG1447	Phosphotransferase system cellobiose-specific component IIA
NLK52_03195	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NLK52_03200	COG2723	6-phospho-beta-galactosidase activity
NLK52_03205	COG2188	Transcriptional regulator
NLK52_03210	COG1940	carbohydrate kinase activity
NLK52_03215	COG1482	cell wall glycoprotein biosynthetic process
NLK52_03220	COG4124	Belongs to the glycosyl hydrolase 26 family
NLK52_03265	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NLK52_03270	COG0802	atpase or kinase
NLK52_03275	COG1214	PFAM Peptidase M22, glycoprotease
NLK52_03280	COG0456	acetyltransferase
NLK52_03285	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NLK52_03290	COG0488	(ABC) transporter
NLK52_03295	COG0315	cyclic pyranopterin monophosphate synthase activity
NLK52_03300	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NLK52_03305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NLK52_03310	COG0805	protein transport
NLK52_03320	COG1266	CAAX protease self-immunity
NLK52_03330	COG0459	protein refolding
NLK52_03340	COG1073	alpha beta
NLK52_03345	COG0457	Tetratricopeptide repeat
NLK52_03350	COG1063	alcohol dehydrogenase
NLK52_03355	COG2211	Major facilitator Superfamily
NLK52_03360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NLK52_03365	COG1842	Phage shock protein A
NLK52_03370	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NLK52_03375	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
NLK52_03380	COG4260	virion core protein, lumpy skin disease virus
NLK52_03390	COG2814	Major facilitator Superfamily
NLK52_03395	COG1063	alcohol dehydrogenase
NLK52_03400	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NLK52_03405	COG0823	Involved in the tonB-independent uptake of proteins
NLK52_03420	COG2267	carboxylic ester hydrolase activity
NLK52_03430	COG2132	Multicopper oxidase
NLK52_03435	COG1113	amino acid transport
NLK52_03445	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NLK52_03450	COG0714	Associated with various cellular activities
NLK52_03455	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
NLK52_03460	COG1305	Transglutaminase-like
NLK52_03465	COG0519	Catalyzes the synthesis of GMP from XMP
NLK52_03465	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NLK52_03480	COG2252	PERMEase
NLK52_03485	COG3064	Membrane
NLK52_03495	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
NLK52_03505	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NLK52_03510	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NLK52_03515	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NLK52_03520	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NLK52_03525	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NLK52_03530	COG0047	phosphoribosylformylglycinamidine synthase activity
NLK52_03535	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NLK52_03540	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NLK52_03545	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NLK52_03550	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NLK52_03555	COG0138	bifunctional purine biosynthesis protein purh
NLK52_03560	COG0151	Belongs to the GarS family
NLK52_03565	COG1522	sequence-specific DNA binding
NLK52_03570	COG0531	amino acid
NLK52_03580	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NLK52_03585	COG1470	cell adhesion involved in biofilm formation
NLK52_03590	COG4496	protein, YerC YecD
NLK52_03595	COG0069	glutamate synthase activity
NLK52_03600	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
NLK52_03605	COG0210	DNA helicase
NLK52_03610	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NLK52_03615	COG4851	CamS sex pheromone cAM373 precursor
NLK52_03620	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NLK52_03625	COG1285	pathogenesis
NLK52_03630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NLK52_03635	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NLK52_03640	COG0154	amidase activity
NLK52_03645	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NLK52_03655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NLK52_03660	COG1597	lipid kinase activity
NLK52_03665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NLK52_03670	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NLK52_03675	COG5293	efflux transmembrane transporter activity
NLK52_03710	COG5444	nuclease activity
NLK52_03720	COG3586	endonuclease activity
NLK52_03730	COG0457	Tetratricopeptide repeat
NLK52_03740	COG0217	transcriptional regulatory protein
NLK52_03750	COG1309	transcriptional regulator
NLK52_03755	COG3631	Ketosteroid isomerase-related protein
NLK52_03775	COG3546	catalase activity
NLK52_03780	COG0454	-acetyltransferase
NLK52_03790	COG5578	integral membrane protein
NLK52_03795	COG2972	Histidine kinase
NLK52_03800	COG2207	Transcriptional regulator
NLK52_03800	COG4753	response regulator
NLK52_03805	COG1653	transport
NLK52_03810	COG1175	transmembrane transport
NLK52_03815	COG0395	ABC-type sugar transport system, permease component
NLK52_03820	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NLK52_03825	COG2207	Transcriptional regulator
NLK52_03830	COG2755	lipolytic protein G-D-S-L family
NLK52_03840	COG5578	integral membrane protein
NLK52_03845	COG3401	FG-GAP repeat protein
NLK52_03850	COG3401	FG-GAP repeat protein
NLK52_03855	COG2755	lipolytic protein G-D-S-L family
NLK52_03860	COG1874	Beta-galactosidase
NLK52_03870	COG1653	transport
NLK52_03875	COG4209	transmembrane transport
NLK52_03880	COG0395	ABC-type sugar transport system, permease component
NLK52_03885	COG1486	melibiose metabolic process
NLK52_03890	COG2323	membrane
NLK52_03895	COG2329	Antibiotic biosynthesis monooxygenase
NLK52_03900	COG0346	lactoylglutathione lyase activity
NLK52_03915	COG5583	Uncharacterized small protein (DUF2292)
NLK52_03920	COG0670	Belongs to the BI1 family
NLK52_03940	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NLK52_03940	COG2124	cytochrome p450
NLK52_03945	COG1368	sulfuric ester hydrolase activity
NLK52_03950	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NLK52_03955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NLK52_03960	COG1442	glycosyl transferase family 8
NLK52_03965	COG1216	Glycosyl transferase, family 2
NLK52_03970	COG1442	glycosyl transferase family 8
NLK52_03975	COG2223	nitrite transmembrane transporter activity
NLK52_03980	COG1011	Hydrolase
NLK52_03985	COG0531	amino acid
NLK52_03990	COG1012	belongs to the aldehyde dehydrogenase family
NLK52_03995	COG0840	transmembrane signaling receptor activity
NLK52_04000	COG0488	(ABC) transporter
NLK52_04010	COG0789	Transcriptional regulator
NLK52_04015	COG2814	Major facilitator Superfamily
NLK52_04030	COG0488	(ABC) transporter
NLK52_04035	COG0513	Belongs to the DEAD box helicase family
NLK52_04040	COG0456	acetyltransferase
NLK52_04045	COG2130	NADP-dependent
NLK52_04050	COG1120	ATPase activity
NLK52_04055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NLK52_04060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NLK52_04065	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NLK52_04080	COG3866	Pectate lyase
NLK52_04085	COG0471	metal ion transport
NLK52_04090	COG3290	protein histidine kinase activity
NLK52_04095	COG4565	transcriptional regulatory protein
NLK52_04100	COG3181	Tripartite tricarboxylate transporter family receptor
NLK52_04105	COG2851	Citrate transporter
NLK52_04110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NLK52_04115	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
NLK52_04120	COG1254	Belongs to the acylphosphatase family
NLK52_04125	COG2258	MOSC domain
NLK52_04145	COG0024	Methionine aminopeptidase
NLK52_04150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NLK52_04150	COG1263	PTS System
NLK52_04155	COG1368	sulfuric ester hydrolase activity
NLK52_04170	COG1115	amino acid carrier protein
NLK52_04175	COG0531	amino acid
NLK52_04190	COG0697	spore germination
NLK52_04195	COG1263	PTS System
NLK52_04195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NLK52_04200	COG0366	Alpha amylase catalytic
NLK52_04205	COG2188	Transcriptional regulator
NLK52_04210	COG0778	Nitroreductase
NLK52_04215	COG0737	Belongs to the 5'-nucleotidase family
NLK52_04220	COG0693	protein deglycase activity
NLK52_04225	COG2814	Major facilitator Superfamily
NLK52_04230	COG4840	Belongs to the UPF0435 family
NLK52_04235	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NLK52_04240	COG4980	gas vesicle protein
NLK52_04245	COG1295	ribonuclease BN
NLK52_04250	COG0477	Major facilitator Superfamily
NLK52_04255	COG0387	Pfam Sodium calcium exchanger
NLK52_04265	COG0668	transmembrane transport
NLK52_04270	COG0535	radical SAM domain protein
NLK52_04280	COG0726	polysaccharide deacetylase
NLK52_04285	COG2084	Dehydrogenase
NLK52_04290	COG0598	Magnesium transport protein CorA
NLK52_04295	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NLK52_04300	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NLK52_04310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NLK52_04315	COG4637	Psort location Cytoplasmic, score
NLK52_04325	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NLK52_04330	COG0022	dehydrogenase e1 component
NLK52_04335	COG0508	dehydrogenase complex catalyzes the overall conversion of
NLK52_04340	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NLK52_04345	COG3284	Transcriptional regulator
NLK52_04355	COG1742	UPF0060 membrane protein
NLK52_04375	COG4842	Belongs to the WXG100 family
NLK52_04380	COG1486	melibiose metabolic process
NLK52_04385	COG1737	Transcriptional regulator
NLK52_04390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NLK52_04390	COG1263	PTS System
NLK52_04395	COG1132	(ABC) transporter
NLK52_04400	COG1132	(ABC) transporter
NLK52_04405	COG2259	Doxx family
NLK52_04410	COG2514	catechol 2,3-dioxygenase activity
NLK52_04415	COG4585	Histidine kinase
NLK52_04420	COG2197	response regulator
NLK52_04425	COG1131	(ABC) transporter
NLK52_04430	COG1511	domain protein
NLK52_04430	COG0842	Transport permease protein
NLK52_04435	COG0842	Transport permease protein
NLK52_04445	COG1695	Transcriptional regulator
NLK52_04450	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NLK52_04470	COG1131	(ABC) transporter
NLK52_04475	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
NLK52_04480	COG1309	transcriptional regulator
NLK52_04485	COG2814	Major facilitator Superfamily
NLK52_04490	COG2318	DinB family
NLK52_04495	COG2814	Major facilitator Superfamily
NLK52_04500	COG1846	Transcriptional regulator
NLK52_04505	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NLK52_04505	COG0392	lysyltransferase activity
NLK52_04510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NLK52_04515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NLK52_04520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NLK52_04525	COG0384	phenazine biosynthesis protein PhzF
NLK52_04530	COG0778	Nitroreductase
NLK52_04545	COG1090	epimerase
NLK52_04550	COG2137	regulation of response to DNA damage stimulus
NLK52_04560	COG2814	Major facilitator Superfamily
NLK52_04575	COG3103	Sh3 type 3 domain protein
NLK52_04580	COG5658	integral membrane protein
NLK52_04585	COG0596	Alpha beta hydrolase
NLK52_04590	COG0463	Glycosyl transferase, family 2
NLK52_04595	COG4485	Bacterial membrane protein, YfhO
NLK52_04600	COG1988	membrane-bound metal-dependent
NLK52_04605	COG1194	a g-specific adenine glycosylase
NLK52_04615	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_04630	COG3557	Belongs to the UPF0374 family
NLK52_04635	COG1132	(ABC) transporter
NLK52_04640	COG4129	membrane
NLK52_04645	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NLK52_04650	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NLK52_04655	COG0735	belongs to the Fur family
NLK52_04765	COG4326	sporulation control protein
NLK52_04775	COG5577	PFAM Coat F domain
NLK52_04780	COG3340	Belongs to the peptidase S51 family
NLK52_04785	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NLK52_04800	COG0753	catalase activity
NLK52_04805	COG1116	anion transmembrane transporter activity
NLK52_04810	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NLK52_04815	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NLK52_04820	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NLK52_04830	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NLK52_04840	COG1476	TRANSCRIPTIONal
NLK52_04850	COG3382	B3 4 domain protein
NLK52_04855	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NLK52_04865	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NLK52_04870	COG0789	Transcriptional regulator
NLK52_04875	COG1664	Polymer-forming cytoskeletal
NLK52_04880	COG1664	Polymer-forming cytoskeletal
NLK52_04885	COG2766	serine protein kinase
NLK52_04890	COG2718	Belongs to the UPF0229 family
NLK52_04895	COG1846	Transcriptional regulator
NLK52_04900	COG1566	PFAM secretion protein HlyD family protein
NLK52_04905	COG2814	Major facilitator Superfamily
NLK52_04910	COG0655	NAD(P)H dehydrogenase (quinone) activity
NLK52_04930	COG1725	Transcriptional regulator
NLK52_04935	COG1131	(ABC) transporter
NLK52_04940	COG1131	(ABC) transporter
NLK52_04945	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NLK52_04950	COG1278	Cold shock
NLK52_04955	COG1464	Belongs to the NlpA lipoprotein family
NLK52_04960	COG3706	GGDEF domain
NLK52_04965	COG1823	symporter activity
NLK52_04985	COG5577	PFAM Coat F domain
NLK52_04990	COG1525	nuclease
NLK52_04990	COG4085	toxin activity
NLK52_04990	COG0737	Belongs to the 5'-nucleotidase family
NLK52_04995	COG3764	Sortase (surface protein transpeptidase)
NLK52_05000	COG0564	pseudouridine synthase activity
NLK52_05010	COG0517	IMP dehydrogenase activity
NLK52_05015	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NLK52_05020	COG3153	acetyltransferase
NLK52_05020	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NLK52_05025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NLK52_05030	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
NLK52_05035	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NLK52_05040	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NLK52_05045	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NLK52_05050	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NLK52_05055	COG4585	Histidine kinase
NLK52_05055	COG2203	Gaf domain
NLK52_05060	COG2197	response regulator
NLK52_05065	COG0431	NADPH-dependent FMN reductase
NLK52_05080	COG1388	LysM domain
NLK52_05080	COG0791	NLP P60 protein
NLK52_05085	COG1959	2 iron, 2 sulfur cluster binding
NLK52_05100	COG2719	SpoVR family
NLK52_05105	COG1785	Belongs to the alkaline phosphatase family
NLK52_05110	COG1388	LysM domain
NLK52_05110	COG0791	NLP P60 protein
NLK52_05115	COG0583	DNA-binding transcription factor activity
NLK52_05120	COG0372	Belongs to the citrate synthase family
NLK52_05125	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_05130	COG0531	amino acid
NLK52_05135	COG0733	neurotransmitter:sodium symporter activity
NLK52_05145	COG0456	acetyltransferase
NLK52_05160	COG1595	DNA-templated transcription, initiation
NLK52_05165	COG0667	Aldo Keto reductase
NLK52_05170	COG0204	Acyl-transferase
NLK52_05175	COG1253	flavin adenine dinucleotide binding
NLK52_05180	COG0789	Transcriptional regulator
NLK52_05185	COG0436	Aminotransferase
NLK52_05190	COG1253	flavin adenine dinucleotide binding
NLK52_05195	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NLK52_05200	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NLK52_05205	COG0584	glycerophosphoryl diester phosphodiesterase
NLK52_05215	COG0668	transmembrane transport
NLK52_05220	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NLK52_05225	COG0726	polysaccharide deacetylase
NLK52_05230	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NLK52_05235	COG1757	Na H antiporter
NLK52_05240	COG0589	response to stress
NLK52_05250	COG1132	(ABC) transporter
NLK52_05255	COG1132	(ABC) transporter
NLK52_05260	COG0702	epimerase
NLK52_05280	COG0189	ligase activity
NLK52_05285	COG0189	ligase activity
NLK52_05290	COG4399	Belongs to the UPF0754 family
NLK52_05295	COG3679	Belongs to the UPF0342 family
NLK52_05300	COG4335	DNA alkylation repair
NLK52_05305	COG0561	phosphatase activity
NLK52_05310	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NLK52_05315	COG0475	glutathione-regulated potassium exporter activity
NLK52_05320	COG0490	domain, Protein
NLK52_05330	COG1024	Enoyl-CoA hydratase
NLK52_05340	COG4152	abc transporter atp-binding protein
NLK52_05345	COG1668	transmembrane transport
NLK52_05350	COG0420	3'-5' exonuclease activity
NLK52_05355	COG4717	serine-type aminopeptidase activity
NLK52_05360	COG3481	metal-dependent phosphohydrolase, HD sub domain
NLK52_05370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NLK52_05400	COG1846	Transcriptional regulator
NLK52_05405	COG4980	gas vesicle protein
NLK52_05420	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NLK52_05425	COG0537	adenosine 5'-monophosphoramidase activity
NLK52_05430	COG1131	(ABC) transporter
NLK52_05435	COG4473	ABC transporter
NLK52_05445	COG1473	amidohydrolase
NLK52_05450	COG3069	C4-dicarboxylate transmembrane transporter activity
NLK52_05460	COG2329	Antibiotic biosynthesis monooxygenase
NLK52_05465	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NLK52_05470	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NLK52_05475	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NLK52_05480	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NLK52_05485	COG1309	transcriptional regulator
NLK52_05490	COG1511	domain protein
NLK52_05495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NLK52_05500	COG4377	Putative membrane peptidase family (DUF2324)
NLK52_05510	COG1363	Peptidase, m42
NLK52_05515	COG4405	Protein conserved in bacteria
NLK52_05520	COG1301	dicarboxylic acid transport
NLK52_05530	COG1234	tRNA 3'-trailer cleavage
NLK52_05535	COG0095	Lipoate-protein ligase
NLK52_05540	COG0702	epimerase
NLK52_05545	COG0318	PFAM AMP-dependent synthetase and ligase
NLK52_05555	COG0501	Belongs to the peptidase M48B family
NLK52_05560	COG1404	Belongs to the peptidase S8 family
NLK52_05570	COG0604	alcohol dehydrogenase
NLK52_05575	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NLK52_05580	COG0406	alpha-ribazole phosphatase activity
NLK52_05585	COG0183	Belongs to the thiolase family
NLK52_05595	COG1268	BioY protein
NLK52_05600	COG0840	transmembrane signaling receptor activity
NLK52_05605	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NLK52_05605	COG0723	plastoquinol--plastocyanin reductase activity
NLK52_05610	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_05620	COG4903	ComK protein
NLK52_05625	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_05635	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NLK52_05650	COG0398	Pfam SNARE associated Golgi protein
NLK52_05655	COG0681	Belongs to the peptidase S26 family
NLK52_05660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NLK52_05665	COG1846	Transcriptional regulator
NLK52_05670	COG0738	Major facilitator superfamily
NLK52_05675	COG0673	inositol 2-dehydrogenase activity
NLK52_05680	COG0561	phosphatase activity
NLK52_05685	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NLK52_05690	COG1609	Transcriptional regulator
NLK52_05695	COG3180	Ammonia monooxygenase
NLK52_05700	COG2814	Major facilitator Superfamily
NLK52_05700	COG0477	Major facilitator Superfamily
NLK52_05705	COG4533	DNA binding
NLK52_05715	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
NLK52_05720	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
NLK52_05725	COG1074	ATP-dependent DNA helicase activity
NLK52_05730	COG0420	3'-5' exonuclease activity
NLK52_05735	COG0419	ATPase involved in DNA repair
NLK52_05740	COG1403	HNH endonuclease
NLK52_05780	COG5337	Spore coat protein CotH
NLK52_05785	COG0179	Fumarylacetoacetate (FAA) hydrolase
NLK52_05795	COG1404	Belongs to the peptidase S8 family
NLK52_05805	COG0367	asparagine synthase
NLK52_05815	COG0534	Mate efflux family protein
NLK52_05820	COG2207	Transcriptional regulator
NLK52_05820	COG1917	Cupin 2, conserved barrel domain protein
NLK52_05825	COG1609	Transcriptional regulator
NLK52_05830	COG0673	inositol 2-dehydrogenase activity
NLK52_05835	COG2318	DinB family
NLK52_05845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NLK52_05850	COG1357	PFAM Pentapeptide repeats (8 copies)
NLK52_05855	COG2267	carboxylic ester hydrolase activity
NLK52_05860	COG0529	Catalyzes the synthesis of activated sulfate
NLK52_05865	COG2046	Belongs to the sulfate adenylyltransferase family
NLK52_05870	COG0175	sulfate reduction
NLK52_05875	COG2045	Belongs to the ComB family
NLK52_05880	COG1809	phosphosulfolactate synthase activity
NLK52_05885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NLK52_05890	COG4948	Mandelate Racemase Muconate Lactonizing
NLK52_05895	COG2814	Major facilitator Superfamily
NLK52_05900	COG0454	-acetyltransferase
NLK52_05905	COG2153	protein acetylation
NLK52_05910	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NLK52_05910	COG0646	methionine synthase
NLK52_05940	COG1695	Transcriptional regulator
NLK52_05955	COG3227	Zinc metalloprotease (Elastase)
NLK52_05960	COG1307	EDD domain protein, DegV family
NLK52_05965	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NLK52_05985	COG0561	phosphatase activity
NLK52_05990	COG1073	alpha beta
NLK52_05995	COG2151	metal-sulfur cluster biosynthetic enzyme
NLK52_06005	COG0277	FAD linked oxidase domain protein
NLK52_06010	COG2271	Major facilitator Superfamily
NLK52_06015	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NLK52_06020	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NLK52_06030	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NLK52_06035	COG0505	Belongs to the CarA family
NLK52_06040	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NLK52_06045	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NLK52_06060	COG2267	carboxylic ester hydrolase activity
NLK52_06070	COG1744	ABC transporter substrate-binding protein PnrA-like
NLK52_06085	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NLK52_06090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NLK52_06095	COG5504	Zn-dependent protease
NLK52_06100	COG0444	Belongs to the ABC transporter superfamily
NLK52_06105	COG4608	Belongs to the ABC transporter superfamily
NLK52_06115	COG0601	transmembrane transport
NLK52_06120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NLK52_06130	COG0180	Tryptophanyl-tRNA synthetase
NLK52_06135	COG4166	transmembrane transport
NLK52_06140	COG0601	transmembrane transport
NLK52_06145	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NLK52_06150	COG0444	Belongs to the ABC transporter superfamily
NLK52_06155	COG4608	Belongs to the ABC transporter superfamily
NLK52_06160	COG2814	Major facilitator Superfamily
NLK52_06165	COG0456	acetyltransferase
NLK52_06170	COG1393	Belongs to the ArsC family
NLK52_06175	COG0861	Integral membrane protein TerC family
NLK52_06185	COG4862	establishment of competence for transformation
NLK52_06195	COG4469	Competence protein
NLK52_06200	COG1164	Oligoendopeptidase f
NLK52_06210	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NLK52_06215	COG2346	COG2346, Truncated hemoglobins
NLK52_06220	COG0741	lytic transglycosylase activity
NLK52_06225	COG4116	CYTH
NLK52_06235	COG2357	RelA SpoT domain protein
NLK52_06240	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NLK52_06245	COG0564	pseudouridine synthase activity
NLK52_06250	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NLK52_06255	COG0569	domain protein
NLK52_06255	COG0475	glutathione-regulated potassium exporter activity
NLK52_06260	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NLK52_06265	COG0352	thiamine-phosphate diphosphorylase activity
NLK52_06270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NLK52_06275	COG2104	thiamine diphosphate biosynthetic process
NLK52_06280	COG2022	thiamine diphosphate biosynthetic process
NLK52_06285	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NLK52_06290	COG0351	phosphomethylpyrimidine kinase
NLK52_06295	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NLK52_06350	COG0210	DNA helicase
NLK52_06360	COG2153	protein acetylation
NLK52_06365	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NLK52_06370	COG2382	esterase
NLK52_06375	COG0626	cystathionine gamma-synthase activity
NLK52_06380	COG0626	cystathionine gamma-synthase activity
NLK52_06385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NLK52_06390	COG5505	Protein of unknown function (DUF819)
NLK52_06450	COG0457	Tetratricopeptide repeat
NLK52_06455	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NLK52_06465	COG3711	transcriptional antiterminator
NLK52_06465	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NLK52_06470	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NLK52_06470	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NLK52_06470	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NLK52_06475	COG1482	cell wall glycoprotein biosynthetic process
NLK52_06485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NLK52_06495	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NLK52_06510	COG0109	protoheme IX farnesyltransferase activity
NLK52_06520	COG0726	polysaccharide deacetylase
NLK52_06535	COG5504	Zn-dependent protease
NLK52_06540	COG2205	protein histidine kinase activity
NLK52_06550	COG3383	formate dehydrogenase (NAD+) activity
NLK52_06555	COG2427	Protein of unknown function (DUF1641)
NLK52_06575	COG2124	cytochrome p450
NLK52_06580	COG1819	glycosyl
NLK52_06590	COG1587	Uroporphyrinogen-III synthase
NLK52_06595	COG0390	transport system, permease component
NLK52_06600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NLK52_06605	COG0697	spore germination
NLK52_06610	COG4297	protein containing double-stranded beta helix domain
NLK52_06620	COG1252	NADH dehydrogenase
NLK52_06625	COG1904	glucuronate isomerase
NLK52_06630	COG2211	Major facilitator Superfamily
NLK52_06635	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
NLK52_06640	COG1063	alcohol dehydrogenase
NLK52_06645	COG1312	Catalyzes the dehydration of D-mannonate
NLK52_06650	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_06655	COG2271	Major facilitator Superfamily
NLK52_06660	COG1609	Transcriptional regulator
NLK52_06665	COG0246	Mannitol dehydrogenase
NLK52_06670	COG2721	sulfolactate sulfo-lyase activity
NLK52_06675	COG0730	response to heat
NLK52_06680	COG2318	DinB family
NLK52_06685	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NLK52_06690	COG0457	Tetratricopeptide repeat
NLK52_06700	COG2350	Protein conserved in bacteria
NLK52_06705	COG1388	LysM domain
NLK52_06705	COG3409	Peptidoglycan-binding domain 1 protein
NLK52_06705	COG5632	N-Acetylmuramoyl-L-alanine amidase
NLK52_06715	COG4195	phage-related replication protein
NLK52_06720	COG3546	catalase activity
NLK52_06725	COG2856	Zn peptidase
NLK52_06730	COG1396	sequence-specific DNA binding
NLK52_06740	COG1522	sequence-specific DNA binding
NLK52_06745	COG1484	DNA-dependent DNA replication
NLK52_06765	COG1595	DNA-templated transcription, initiation
NLK52_06770	COG3728	DNA packaging
NLK52_06770	COG5484	DNA packaging
NLK52_06775	COG1783	phage Terminase large subunit
NLK52_06780	COG5518	Phage portal protein
NLK52_06785	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NLK52_06790	COG4653	Phage capsid family
NLK52_06840	COG5412	phage tail tape measure protein
NLK52_06840	COG3953	SLT domain
NLK52_06845	COG1652	LysM domain
NLK52_06850	COG4193	domain, Protein
NLK52_06860	COG3628	GPW Gp25 family protein
NLK52_06865	COG3299	homolog of phage Mu protein gp47
NLK52_06870	COG3778	Protein conserved in bacteria
NLK52_06910	COG5632	N-Acetylmuramoyl-L-alanine amidase
NLK52_06910	COG3409	Peptidoglycan-binding domain 1 protein
NLK52_06930	COG0306	phosphate transporter
NLK52_06935	COG1392	Phosphate transport regulator
NLK52_06940	COG0531	amino acid
NLK52_06945	COG0346	lactoylglutathione lyase activity
NLK52_06955	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NLK52_06960	COG0463	Glycosyl transferase, family 2
NLK52_06965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NLK52_06970	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NLK52_06975	COG2362	D-Aminopeptidase
NLK52_06980	COG0601	transmembrane transport
NLK52_06985	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NLK52_06990	COG0444	Belongs to the ABC transporter superfamily
NLK52_06995	COG4166	transmembrane transport
NLK52_07000	COG1619	proteins homologs of microcin C7 resistance protein MccF
NLK52_07005	COG4948	Mandelate Racemase Muconate Lactonizing
NLK52_07010	COG0791	NLP P60 protein
NLK52_07015	COG4608	Belongs to the ABC transporter superfamily
NLK52_07020	COG2706	6-phosphogluconolactonase activity
NLK52_07025	COG1834	amidinotransferase
NLK52_07030	COG1607	acyl-coa hydrolase
NLK52_07035	COG1017	nitric oxide dioxygenase activity
NLK52_07035	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NLK52_07045	COG2323	membrane
NLK52_07050	COG2318	DinB family
NLK52_07055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NLK52_07060	COG2076	Multidrug Resistance protein
NLK52_07065	COG2076	Multidrug Resistance protein
NLK52_07070	COG0788	formyltetrahydrofolate deformylase activity
NLK52_07075	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NLK52_07080	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NLK52_07085	COG1764	response to oxidative stress
NLK52_07090	COG1846	Transcriptional regulator
NLK52_07095	COG1764	response to oxidative stress
NLK52_07100	COG0590	tRNA wobble adenosine to inosine editing
NLK52_07110	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NLK52_07115	COG1404	Belongs to the peptidase S8 family
NLK52_07120	COG1366	Belongs to the anti-sigma-factor antagonist family
NLK52_07125	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NLK52_07130	COG1122	ATPase activity
NLK52_07135	COG4721	ABC-type cobalt transport system, permease component
NLK52_07145	COG0745	RESPONSE REGULATOR receiver
NLK52_07150	COG3850	Histidine kinase
NLK52_07150	COG5002	protein histidine kinase activity
NLK52_07155	COG3212	peptidase
NLK52_07160	COG3212	peptidase
NLK52_07170	COG2239	Acts as a magnesium transporter
NLK52_07175	COG0789	Transcriptional regulator
NLK52_07190	COG1846	Transcriptional regulator
NLK52_07200	COG0726	polysaccharide deacetylase
NLK52_07205	COG1408	metallophosphoesterase
NLK52_07215	COG0463	Glycosyl transferase, family 2
NLK52_07220	COG1793	dna ligase
NLK52_07220	COG3285	dna ligase
NLK52_07225	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NLK52_07230	COG5001	Diguanylate cyclase
NLK52_07230	COG3300	MHYT domain
NLK52_07235	COG0586	Pfam SNARE associated Golgi protein
NLK52_07240	COG0861	Integral membrane protein TerC family
NLK52_07245	COG1191	sigma factor activity
NLK52_07265	COG0501	Belongs to the peptidase M48B family
NLK52_07270	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NLK52_07285	COG3594	Acyltransferase
NLK52_07290	COG5002	protein histidine kinase activity
NLK52_07295	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NLK52_07305	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NLK52_07310	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
NLK52_07315	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NLK52_07320	COG0436	Aminotransferase
NLK52_07325	COG1850	ribulose-bisphosphate carboxylase activity
NLK52_07330	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
NLK52_07335	COG0235	Class ii aldolase
NLK52_07340	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
NLK52_07345	COG3339	Conserved Protein
NLK52_07360	COG3852	Histidine kinase
NLK52_07365	COG1846	Transcriptional regulator
NLK52_07370	COG1360	Flagellar Motor Protein
NLK52_07375	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NLK52_07380	COG0542	response to heat
NLK52_07385	COG3949	Membrane
NLK52_07390	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NLK52_07395	COG0720	synthase
NLK52_07400	COG0602	queuosine metabolic process
NLK52_07405	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NLK52_07410	COG1388	LysM domain
NLK52_07410	COG4641	Protein conserved in bacteria
NLK52_07415	COG1388	LysM domain
NLK52_07420	COG3858	chitin binding
NLK52_07430	COG4873	Protein conserved in bacteria
NLK52_07440	COG3773	Cell wall hydrolase
NLK52_07445	COG2244	polysaccharide biosynthetic process
NLK52_07450	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NLK52_07455	COG2217	Heavy metal translocating P-type atpase
NLK52_07465	COG0006	proline dipeptidase activity
NLK52_07470	COG1609	Transcriptional regulator
NLK52_07475	COG3711	transcriptional antiterminator
NLK52_07480	COG2190	(PTS) system
NLK52_07480	COG1263	PTS System
NLK52_07480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NLK52_07485	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NLK52_07490	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NLK52_07500	COG1533	DNA photolyase activity
NLK52_07505	COG0456	acetyltransferase
NLK52_07510	COG0840	transmembrane signaling receptor activity
NLK52_07515	COG2084	Dehydrogenase
NLK52_07520	COG2340	Cysteine-rich secretory protein family
NLK52_07525	COG0768	penicillin binding
NLK52_07530	COG4191	Histidine kinase
NLK52_07535	COG0436	Aminotransferase
NLK52_07545	COG0835	chemotaxis
NLK52_07545	COG0784	Response regulator, receiver
NLK52_07555	COG2814	Major facilitator Superfamily
NLK52_07560	COG1376	ErfK ybiS ycfS ynhG family protein
NLK52_07565	COG1408	metallophosphoesterase
NLK52_07570	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_07575	COG2200	EAL domain
NLK52_07580	COG4703	Protein of unknown function (DUF1797)
NLK52_07585	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
NLK52_07595	COG0517	IMP dehydrogenase activity
NLK52_07600	COG0583	DNA-binding transcription factor activity
NLK52_07605	COG0716	FMN binding
NLK52_07615	COG0716	FMN binding
NLK52_07620	COG2171	N-acyltransferase activity
NLK52_07625	COG1473	amidohydrolase
NLK52_07635	COG0668	transmembrane transport
NLK52_07640	COG0450	alkyl hydroperoxide reductase
NLK52_07645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NLK52_07660	COG0746	molybdenum cofactor guanylyltransferase activity
NLK52_07665	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NLK52_07670	COG0303	'Molybdopterin
NLK52_07675	COG1763	Mo-molybdopterin cofactor biosynthetic process
NLK52_07680	COG0314	molybdopterin synthase activity
NLK52_07685	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NLK52_07690	COG1132	(ABC) transporter
NLK52_07695	COG1132	(ABC) transporter
NLK52_07705	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NLK52_07710	COG1136	(ABC) transporter
NLK52_07715	COG0577	efflux transmembrane transporter activity
NLK52_07720	COG1349	DNA-binding transcription factor activity
NLK52_07725	COG1105	Belongs to the carbohydrate kinase PfkB family
NLK52_07730	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NLK52_07730	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NLK52_07730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NLK52_07735	COG0681	Belongs to the peptidase S26 family
NLK52_07745	COG0488	(ABC) transporter
NLK52_07755	COG2309	aminopeptidase activity
NLK52_07765	COG1077	Cell shape determining protein MreB Mrl
NLK52_07770	COG2002	toxin-antitoxin pair type II binding
NLK52_07775	COG3852	Histidine kinase
NLK52_07780	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
NLK52_07780	COG2105	PFAM AIG2 family protein
NLK52_07785	COG0569	domain protein
NLK52_07790	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NLK52_07795	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NLK52_07800	COG5503	Protein of unknown function (DUF1447)
NLK52_07805	COG0561	phosphatase activity
NLK52_07810	COG0242	peptide deformylase activity
NLK52_07820	COG0497	DNA recombination
NLK52_07825	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NLK52_07830	COG0022	dehydrogenase e1 component
NLK52_07835	COG0508	dehydrogenase complex catalyzes the overall conversion of
NLK52_07840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NLK52_07845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NLK52_07855	COG1982	Orn Lys Arg decarboxylase major
NLK52_07860	COG4476	Belongs to the UPF0223 family
NLK52_07865	COG4493	Belongs to the UPF0637 family
NLK52_07875	COG0483	inositol monophosphate 1-phosphatase activity
NLK52_07885	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NLK52_07905	COG1595	DNA-templated transcription, initiation
NLK52_07925	COG1217	gtp-binding protein TYPA
NLK52_07935	COG4896	Protein conserved in bacteria
NLK52_07945	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NLK52_07950	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NLK52_07955	COG2066	Belongs to the glutaminase family
NLK52_07960	COG4838	Belongs to the UPF0358 family
NLK52_07965	COG0772	Belongs to the SEDS family
NLK52_07970	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NLK52_07975	COG1612	heme a metabolic process
NLK52_07980	COG0109	protoheme IX farnesyltransferase activity
NLK52_07985	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NLK52_07985	COG2010	Cytochrome c
NLK52_07990	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NLK52_07995	COG1845	cytochrome c oxidase, subunit III
NLK52_08000	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NLK52_08005	COG3336	cytochrome c oxidase
NLK52_08015	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
NLK52_08020	COG2340	Cysteine-rich secretory protein family
NLK52_08035	COG3679	Belongs to the UPF0342 family
NLK52_08040	COG4471	UPF0298 protein
NLK52_08045	COG0742	ribosomal rna small subunit methyltransferase
NLK52_08050	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NLK52_08055	COG3314	Sporulation integral membrane protein YlbJ
NLK52_08060	COG1752	Esterase of the alpha-beta hydrolase superfamily
NLK52_08065	COG3480	Lon protease (S16) C-terminal proteolytic domain
NLK52_08085	COG1399	metal-binding, possibly nucleic acid-binding protein
NLK52_08100	COG0454	-acetyltransferase
NLK52_08105	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NLK52_08110	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
NLK52_08115	COG2001	Belongs to the MraZ family
NLK52_08120	COG0275	rRNA processing
NLK52_08125	COG4839	cell division protein FtsL
NLK52_08130	COG0768	penicillin binding
NLK52_08135	COG0768	penicillin binding
NLK52_08140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NLK52_08145	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NLK52_08150	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NLK52_08155	COG0772	Belongs to the SEDS family
NLK52_08160	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NLK52_08165	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NLK52_08170	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NLK52_08175	COG3879	Bacterial protein of unknown function (DUF881)
NLK52_08180	COG3879	Bacterial protein of unknown function (DUF881)
NLK52_08185	COG3856	small basic protein
NLK52_08190	COG0849	cell division
NLK52_08195	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NLK52_08200	COG4412	M6 family metalloprotease domain protein
NLK52_08200	COG1404	Belongs to the peptidase S8 family
NLK52_08210	COG1191	sigma factor activity
NLK52_08215	COG1191	sigma factor activity
NLK52_08220	COG1119	ATPase activity
NLK52_08225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NLK52_08230	COG1873	PFAM PRC-barrel domain
NLK52_08235	COG1496	oxidoreductase activity
NLK52_08240	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NLK52_08245	COG1799	cell septum assembly
NLK52_08250	COG0762	integral membrane protein
NLK52_08255	COG2302	S4 RNA-binding domain
NLK52_08260	COG3599	regulation of cell shape
NLK52_08265	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NLK52_08270	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NLK52_08275	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NLK52_08280	COG0564	pseudouridine synthase activity
NLK52_08285	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NLK52_08290	COG2233	PERMEase
NLK52_08295	COG0540	Belongs to the ATCase OTCase family
NLK52_08300	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NLK52_08305	COG0505	Belongs to the CarA family
NLK52_08310	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NLK52_08315	COG0543	2 iron, 2 sulfur cluster binding
NLK52_08320	COG0167	dihydroorotate dehydrogenase activity
NLK52_08325	COG0284	orotidine-5'-phosphate decarboxylase activity
NLK52_08330	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NLK52_08335	COG0175	sulfate reduction
NLK52_08340	COG0306	phosphate transporter
NLK52_08345	COG2046	Belongs to the sulfate adenylyltransferase family
NLK52_08350	COG0529	Catalyzes the synthesis of activated sulfate
NLK52_08355	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NLK52_08360	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
NLK52_08365	COG1648	precorrin-2 dehydrogenase activity
NLK52_08370	COG1293	RNA-binding protein homologous to eukaryotic snRNP
NLK52_08375	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NLK52_08380	COG1561	YicC-like family, N-terminal region
NLK52_08390	COG0194	GDP metabolic process
NLK52_08395	COG1758	RNA polymerase activity
NLK52_08400	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NLK52_08405	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NLK52_08410	COG0242	peptide deformylase activity
NLK52_08415	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NLK52_08420	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NLK52_08420	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NLK52_08425	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NLK52_08430	COG0631	protein serine/threonine phosphatase activity
NLK52_08435	COG2815	serine threonine protein kinase
NLK52_08435	COG0515	serine threonine protein kinase
NLK52_08440	COG1162	GTPase activity
NLK52_08445	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NLK52_08450	COG1564	THIamine pyrophosphokinase
NLK52_08460	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NLK52_08465	COG1302	Protein conserved in bacteria
NLK52_08470	COG1461	Dihydroxyacetone kinase
NLK52_08475	COG1760	l-serine dehydratase
NLK52_08480	COG1760	l-serine dehydratase
NLK52_08485	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NLK52_08490	COG2050	protein possibly involved in aromatic compounds catabolism
NLK52_08490	COG1349	DNA-binding transcription factor activity
NLK52_08495	COG0416	fatty acid biosynthetic process
NLK52_08500	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NLK52_08505	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_08515	COG0571	ribonuclease III activity
NLK52_08520	COG1196	nuclear chromosome segregation
NLK52_08525	COG0552	protein localization to endoplasmic reticulum
NLK52_08535	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
NLK52_08540	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NLK52_08545	COG0228	four-way junction DNA binding
NLK52_08550	COG1837	Belongs to the UPF0109 family
NLK52_08560	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NLK52_08565	COG0336	Belongs to the RNA methyltransferase TrmD family
NLK52_08570	COG0335	large ribosomal subunit rRNA binding
NLK52_08575	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NLK52_08580	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NLK52_08590	COG2257	FlhB HrpN YscU SpaS Family
NLK52_08595	COG0045	succinate-CoA ligase (ADP-forming) activity
NLK52_08600	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NLK52_08610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NLK52_08615	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
NLK52_08620	COG4974	Belongs to the 'phage' integrase family
NLK52_08625	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NLK52_08630	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NLK52_08635	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NLK52_08640	COG1815	bacterial-type flagellum-dependent cell motility
NLK52_08645	COG1558	bacterial-type flagellum-dependent cell motility
NLK52_08650	COG1677	Flagellar hook-basal body complex protein FliE
NLK52_08655	COG1766	The M ring may be actively involved in energy transduction
NLK52_08660	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NLK52_08665	COG1317	bacterial-type flagellum organization
NLK52_08670	COG1157	protein secretion by the type III secretion system
NLK52_08675	COG2882	bacterial-type flagellum organization
NLK52_08680	COG3334	PFAM MgtE intracellular
NLK52_08685	COG3144	bacterial-type flagellum assembly
NLK52_08690	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
NLK52_08695	COG4786	Flagellar basal body rod
NLK52_08700	COG1582	Flagellar protein (FlbD)
NLK52_08705	COG1580	Controls the rotational direction of flagella during chemotaxis
NLK52_08710	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NLK52_08715	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NLK52_08715	COG1776	CheC inhibitor of MCP methylation
NLK52_08720	COG2201	protein-glutamate methylesterase activity
NLK52_08725	COG3190	flagellar
NLK52_08730	COG1338	Plays a role in the flagellum-specific transport system
NLK52_08735	COG1987	bacterial-type flagellum assembly
NLK52_08740	COG1684	flagellar biosynthetic protein fliR
NLK52_08745	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NLK52_08750	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NLK52_08755	COG1419	protein localization to endoplasmic reticulum
NLK52_08760	COG0455	bacterial-type flagellum organization
NLK52_08765	COG2201	protein-glutamate methylesterase activity
NLK52_08770	COG0643	Histidine kinase
NLK52_08770	COG2198	Histidine kinase
NLK52_08775	COG0835	chemotaxis
NLK52_08780	COG1776	CheC inhibitor of MCP methylation
NLK52_08785	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
NLK52_08790	COG1191	sigma factor activity
NLK52_08800	COG0052	Belongs to the universal ribosomal protein uS2 family
NLK52_08805	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NLK52_08810	COG0528	UMP kinase activity
NLK52_08815	COG0233	cytoplasmic translational termination
NLK52_08820	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NLK52_08825	COG4589	Belongs to the CDS family
NLK52_08830	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NLK52_08835	COG0750	zinc metalloprotease
NLK52_08840	COG0442	prolyl-tRNA aminoacylation
NLK52_08845	COG2176	DNA-directed DNA polymerase activity
NLK52_08850	COG0779	Required for maturation of 30S ribosomal subunits
NLK52_08855	COG0195	Participates in both transcription termination and antitermination
NLK52_08860	COG2740	Nucleic-acid-binding protein implicated in transcription termination
NLK52_08865	COG1358	cellular component organization or biogenesis
NLK52_08870	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NLK52_08875	COG1550	Protein conserved in bacteria
NLK52_08880	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NLK52_08885	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NLK52_08890	COG0196	riboflavin kinase activity
NLK52_08895	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NLK52_08900	COG1185	polyribonucleotide nucleotidyltransferase activity
NLK52_08905	COG0726	polysaccharide deacetylase
NLK52_08910	COG0612	Peptidase, M16
NLK52_08915	COG1873	PFAM PRC-barrel domain
NLK52_08920	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NLK52_08925	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NLK52_08930	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NLK52_08935	COG0527	aspartate kinase activity
NLK52_08940	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NLK52_08945	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NLK52_08950	COG0740	serine-type endopeptidase activity
NLK52_08960	COG1674	ftsk spoiiie
NLK52_08960	COG4980	gas vesicle protein
NLK52_08965	COG2188	Transcriptional regulator
NLK52_08970	COG2814	Major facilitator Superfamily
NLK52_08975	COG0612	Peptidase, M16
NLK52_08980	COG0612	Peptidase, M16
NLK52_08985	COG0300	oxidoreductase activity
NLK52_09000	COG1426	Protein conserved in bacteria
NLK52_09005	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NLK52_09010	COG1058	Belongs to the CinA family
NLK52_09010	COG1546	Belongs to the CinA family
NLK52_09015	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NLK52_09020	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NLK52_09025	COG1418	mRNA catabolic process
NLK52_09030	COG1692	metallophosphoesterase
NLK52_09035	COG2359	stage V sporulation protein S
NLK52_09040	COG1063	alcohol dehydrogenase
NLK52_09045	COG0156	8-amino-7-oxononanoate synthase activity
NLK52_09050	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NLK52_09055	COG4550	Control of competence regulator ComK, YlbF/YmcA
NLK52_09065	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NLK52_09070	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NLK52_09085	COG3226	Transcriptional regulator
NLK52_09090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NLK52_09100	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NLK52_09105	COG3321	synthase
NLK52_09110	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NLK52_09110	COG2070	2-Nitropropane dioxygenase
NLK52_09115	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NLK52_09120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NLK52_09125	COG3425	synthase
NLK52_09130	COG1024	Enoyl-CoA hydratase
NLK52_09135	COG1024	Enoyl-CoA hydratase
NLK52_09140	COG3321	synthase
NLK52_09140	COG0300	oxidoreductase activity
NLK52_09140	COG0318	PFAM AMP-dependent synthetase and ligase
NLK52_09140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NLK52_09140	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_09145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NLK52_09145	COG4221	oxidoreductase activity
NLK52_09145	COG3321	synthase
NLK52_09145	COG0300	oxidoreductase activity
NLK52_09150	COG3321	synthase
NLK52_09150	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_09150	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NLK52_09150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NLK52_09150	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NLK52_09155	COG4221	oxidoreductase activity
NLK52_09155	COG3321	synthase
NLK52_09155	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_09155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NLK52_09160	COG3321	synthase
NLK52_09160	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
NLK52_09160	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NLK52_09160	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NLK52_09165	COG2124	cytochrome p450
NLK52_09175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NLK52_09180	COG1404	Belongs to the peptidase S8 family
NLK52_09190	COG4195	phage-related replication protein
NLK52_09195	COG1764	response to oxidative stress
NLK52_09200	COG2076	Multidrug Resistance protein
NLK52_09205	COG2076	Multidrug Resistance protein
NLK52_09220	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NLK52_09225	COG1923	regulation of RNA biosynthetic process
NLK52_09240	COG1780	Probably involved in ribonucleotide reductase function
NLK52_09245	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NLK52_09250	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NLK52_09255	COG4112	unkown
NLK52_09260	COG0860	N-Acetylmuramoyl-L-alanine amidase
NLK52_09265	COG0464	growth
NLK52_09270	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NLK52_09275	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
NLK52_09280	COG0789	Transcriptional regulator
NLK52_09285	COG0174	glutamine synthetase
NLK52_09335	COG4282	regulation of fungal-type cell wall biogenesis
NLK52_09345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NLK52_09360	COG3655	Transcriptional regulator
NLK52_09390	COG2211	Major facilitator Superfamily
NLK52_09395	COG3507	Belongs to the glycosyl hydrolase 43 family
NLK52_09400	COG1940	carbohydrate kinase activity
NLK52_09405	COG2115	Belongs to the xylose isomerase family
NLK52_09410	COG1070	Carbohydrate kinase
NLK52_09420	COG1525	nuclease
NLK52_09425	COG2814	Major facilitator Superfamily
NLK52_09430	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NLK52_09440	COG0756	dUTP diphosphatase activity
NLK52_09455	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NLK52_09485	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NLK52_09500	COG3832	glyoxalase III activity
NLK52_09510	COG0697	spore germination
NLK52_09515	COG0531	amino acid
NLK52_09545	COG4195	phage-related replication protein
NLK52_09555	COG0346	lactoylglutathione lyase activity
NLK52_09565	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NLK52_09570	COG1388	LysM domain
NLK52_09575	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NLK52_09580	COG4224	UPF0291 protein
NLK52_09585	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NLK52_09595	COG3763	UPF0154 protein
NLK52_09605	COG0785	Cytochrome C biogenesis protein
NLK52_09610	COG2201	protein-glutamate methylesterase activity
NLK52_09615	COG4846	Membrane protein involved in cytochrome C biogenesis
NLK52_09625	COG0071	Belongs to the small heat shock protein (HSP20) family
NLK52_09640	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NLK52_09645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NLK52_09665	COG0824	Thioesterase
NLK52_09675	COG4841	protein insertion into membrane
NLK52_09680	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NLK52_09685	COG1832	CoA-binding protein
NLK52_09690	COG0187	DNA topoisomerase II activity
NLK52_09695	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NLK52_09705	COG1115	amino acid carrier protein
NLK52_09710	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NLK52_09730	COG5520	Belongs to the glycosyl hydrolase 30 family
NLK52_09735	COG3507	Belongs to the glycosyl hydrolase 43 family
NLK52_09740	COG2246	polysaccharide biosynthetic process
NLK52_09745	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NLK52_09750	COG0586	Pfam SNARE associated Golgi protein
NLK52_09755	COG2404	hydrolase activity, acting on ester bonds
NLK52_09760	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NLK52_09765	COG1024	Enoyl-CoA hydratase
NLK52_09770	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NLK52_09775	COG0511	ligase activity, forming carbon-carbon bonds
NLK52_09780	COG0439	Biotin carboxylase
NLK52_09785	COG0318	PFAM AMP-dependent synthetase and ligase
NLK52_09790	COG1960	acyl-CoA dehydrogenase activity
NLK52_09805	COG1649	PFAM Uncharacterised BCR, COG1649
NLK52_09815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NLK52_09815	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
NLK52_09820	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NLK52_09825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NLK52_09830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NLK52_09840	COG2027	D-alanyl-D-alanine carboxypeptidase
NLK52_09845	COG2017	converts alpha-aldose to the beta-anomer
NLK52_09850	COG0534	Mate efflux family protein
NLK52_09865	COG0582	viral genome integration into host DNA
NLK52_09870	COG0166	Belongs to the GPI family
NLK52_09875	COG0405	Gamma-glutamyltransferase
NLK52_09880	COG0583	DNA-binding transcription factor activity
NLK52_09885	COG0604	alcohol dehydrogenase
NLK52_09890	COG0493	'glutamate synthase
NLK52_09895	COG0067	glutamate synthase
NLK52_09895	COG0070	glutamate synthase
NLK52_09895	COG0069	glutamate synthase activity
NLK52_09900	COG0583	DNA-binding transcription factor activity
NLK52_09905	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NLK52_09910	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NLK52_09920	COG0300	oxidoreductase activity
NLK52_09925	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
NLK52_09935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NLK52_09940	COG2814	Major facilitator Superfamily
NLK52_09945	COG1070	Carbohydrate kinase
NLK52_09950	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NLK52_09955	COG0243	molybdopterin cofactor binding
NLK52_09980	COG5278	phosphoserine phosphatase activity
NLK52_09980	COG0840	transmembrane signaling receptor activity
NLK52_09985	COG2368	4-hydroxyphenylacetate
NLK52_09990	COG4305	rare lipoprotein A
NLK52_09995	COG3619	membrane
NLK52_10000	COG3866	Pectate lyase
NLK52_10005	COG2135	peptidase activity
NLK52_10015	COG2140	Oxalate decarboxylase
NLK52_10045	COG2720	vancomycin resistance protein
NLK52_10060	COG3739	integral membrane protein
NLK52_10065	COG0583	DNA-binding transcription factor activity
NLK52_10070	COG0697	spore germination
NLK52_10080	COG0693	protein deglycase activity
NLK52_10085	COG2367	Beta-lactamase
NLK52_10100	COG3848	Pyruvate phosphate dikinase
NLK52_10100	COG0574	Belongs to the PEP-utilizing enzyme family
NLK52_10105	COG0726	polysaccharide deacetylase
NLK52_10150	COG5444	nuclease activity
NLK52_10155	COG4282	regulation of fungal-type cell wall biogenesis
NLK52_10160	COG1231	oxidoreductase activity
NLK52_10165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NLK52_10170	COG2207	Transcriptional regulator
NLK52_10170	COG0662	Cupin 2, conserved barrel domain protein
NLK52_10185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NLK52_10190	COG3708	Transcriptional regulator
NLK52_10195	COG2378	regulation of single-species biofilm formation
NLK52_10205	COG0640	Transcriptional regulator
NLK52_10210	COG0741	lytic transglycosylase activity
NLK52_10215	COG2322	membrane
NLK52_10230	COG1619	proteins homologs of microcin C7 resistance protein MccF
NLK52_10235	COG3239	Fatty acid desaturase
NLK52_10240	COG4585	Histidine kinase
NLK52_10245	COG2197	response regulator
NLK52_10250	COG3584	3D domain protein
NLK52_10250	COG1388	LysM domain
NLK52_10255	COG0514	ATP-dependent DNA helicase (RecQ)
NLK52_10265	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NLK52_10270	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NLK52_10285	COG0071	Belongs to the small heat shock protein (HSP20) family
NLK52_10310	COG1012	belongs to the aldehyde dehydrogenase family
NLK52_10315	COG1657	PFAM Prenyltransferase squalene oxidase
NLK52_10320	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NLK52_10325	COG0733	neurotransmitter:sodium symporter activity
NLK52_10330	COG0385	Bile acid
NLK52_10335	COG0508	dehydrogenase complex catalyzes the overall conversion of
NLK52_10340	COG0567	Dehydrogenase, E1 component
NLK52_10345	COG4548	von Willebrand factor, type A
NLK52_10350	COG0714	Associated with various cellular activities
NLK52_10355	COG2032	superoxide dismutase activity
NLK52_10360	COG0791	NLP P60 protein
NLK52_10360	COG1388	LysM domain
NLK52_10365	COG1819	glycosyl
NLK52_10370	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NLK52_10375	COG0534	Mate efflux family protein
NLK52_10380	COG1366	Belongs to the anti-sigma-factor antagonist family
NLK52_10385	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NLK52_10390	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NLK52_10400	COG2962	Rard protein
NLK52_10415	COG2610	gluconate transmembrane transporter activity
NLK52_10420	COG1942	4-Oxalocrotonate Tautomerase
NLK52_10425	COG1733	regulation of RNA biosynthetic process
NLK52_10430	COG0778	Nitroreductase
NLK52_10435	COG0400	carboxylic ester hydrolase activity
NLK52_10440	COG0346	lactoylglutathione lyase activity
NLK52_10450	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NLK52_10455	COG3409	Peptidoglycan-binding domain 1 protein
NLK52_10455	COG0793	Belongs to the peptidase S41A family
NLK52_10460	COG2226	methyltransferase
NLK52_10470	COG1876	peptidase activity
NLK52_10475	COG0813	purine-nucleoside phosphorylase activity
NLK52_10490	COG0671	phosphoesterase, PA-phosphatase related
NLK52_10510	COG4479	Belongs to the UPF0346 family
NLK52_10520	COG1509	lysine 2,3-aminomutase activity
NLK52_10525	COG0456	acetyltransferase
NLK52_10530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NLK52_10535	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NLK52_10540	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NLK52_10545	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NLK52_10560	COG0456	acetyltransferase
NLK52_10565	COG0463	Glycosyl transferase, family 2
NLK52_10580	COG4641	Protein conserved in bacteria
NLK52_10585	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
NLK52_10590	COG1086	Polysaccharide biosynthesis protein
NLK52_10595	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NLK52_10600	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NLK52_10605	COG1846	Transcriptional regulator
NLK52_10610	COG0534	Mate efflux family protein
NLK52_10620	COG4698	Protein conserved in bacteria
NLK52_10625	COG2755	lipolytic protein G-D-S-L family
NLK52_10630	COG1999	signal sequence binding
NLK52_10640	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NLK52_10645	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NLK52_10650	COG1272	protein, Hemolysin III
NLK52_10655	COG0204	Acyl-transferase
NLK52_10660	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NLK52_10665	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
NLK52_10670	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NLK52_10680	COG2136	Putative SAM-dependent methyltransferase
NLK52_10680	COG2521	methyltransferase
NLK52_10690	COG0129	dihydroxy-acid dehydratase activity
NLK52_10700	COG1413	lyase activity
NLK52_10705	COG1418	mRNA catabolic process
NLK52_10710	COG0386	Belongs to the glutathione peroxidase family
NLK52_10715	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NLK52_10720	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NLK52_10730	COG1278	Cold shock
NLK52_10750	COG0328	RNA-DNA hybrid ribonuclease activity
NLK52_10755	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NLK52_10760	COG0328	RNA-DNA hybrid ribonuclease activity
NLK52_10770	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NLK52_10785	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NLK52_10795	COG1755	Isoprenylcysteine carboxyl methyltransferase
NLK52_10800	COG3424	synthase
NLK52_10805	COG2233	PERMEase
NLK52_10810	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NLK52_10815	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
NLK52_10825	COG0800	Aldolase
NLK52_10830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NLK52_10835	COG1609	Transcriptional regulator
NLK52_10840	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
NLK52_10845	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_10850	COG1199	ATP-dependent helicase activity
NLK52_10865	COG0116	Belongs to the methyltransferase superfamily
NLK52_10880	COG4474	Belongs to the UPF0398 family
NLK52_10895	COG3359	exonuclease
NLK52_10900	COG1205	dead DEAH box helicase
NLK52_10900	COG1111	helicase
NLK52_10905	COG2190	(PTS) system
NLK52_10910	COG0071	Belongs to the small heat shock protein (HSP20) family
NLK52_10945	COG3331	DNA recombination
NLK52_10950	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NLK52_10950	COG4499	WXG100 protein secretion system (Wss), protein YukC
NLK52_10960	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NLK52_10965	COG3935	DnaD domain protein
NLK52_10970	COG0017	Asparaginyl-tRNA synthetase
NLK52_10975	COG0436	Aminotransferase
NLK52_10980	COG5353	protein conserved in bacteria
NLK52_10990	COG1199	ATP-dependent helicase activity
NLK52_10990	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NLK52_10995	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NLK52_11000	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NLK52_11005	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NLK52_11010	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NLK52_11010	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NLK52_11015	COG0617	tRNA 3'-terminal CCA addition
NLK52_11020	COG0438	transferase activity, transferring glycosyl groups
NLK52_11025	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NLK52_11030	COG1803	Methylglyoxal synthase
NLK52_11035	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NLK52_11040	COG1694	Mazg nucleotide pyrophosphohydrolase
NLK52_11045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NLK52_11055	COG4347	Protein of unknown function (DUF1405)
NLK52_11060	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NLK52_11060	COG2010	Cytochrome c
NLK52_11065	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NLK52_11070	COG0723	plastoquinol--plastocyanin reductase activity
NLK52_11080	COG5582	Belongs to the UPF0302 family
NLK52_11085	COG0457	Tetratricopeptide repeat
NLK52_11090	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NLK52_11095	COG0287	Prephenate dehydrogenase
NLK52_11100	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NLK52_11105	COG0159	tryptophan synthase activity
NLK52_11110	COG0133	tryptophan synthase activity
NLK52_11115	COG0135	phosphoribosylanthranilate isomerase activity
NLK52_11125	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NLK52_11130	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NLK52_11135	COG4401	Chorismate mutase type I
NLK52_11140	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NLK52_11145	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NLK52_11150	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NLK52_11155	COG0105	UTP biosynthetic process
NLK52_11160	COG0142	geranyltranstransferase activity
NLK52_11165	COG2226	methyltransferase
NLK52_11170	COG0142	geranyltranstransferase activity
NLK52_11180	COG0302	gtp cyclohydrolase
NLK52_11185	COG0776	regulation of translation
NLK52_11190	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NLK52_11205	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NLK52_11210	COG1160	GTP binding
NLK52_11235	COG1304	FMN binding
NLK52_11240	COG0539	negative regulation of cytoplasmic translation
NLK52_11245	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NLK52_11255	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
NLK52_11260	COG2959	enzyme of heme biosynthesis
NLK52_11265	COG3409	Peptidoglycan-binding domain 1 protein
NLK52_11265	COG3773	Cell wall hydrolase
NLK52_11270	COG2339	peptidase activity
NLK52_11275	COG0492	ferredoxin-NADP+ reductase activity
NLK52_11280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NLK52_11285	COG4862	establishment of competence for transformation
NLK52_11290	COG1408	metallophosphoesterase
NLK52_11300	COG1388	LysM domain
NLK52_11305	COG1266	CAAX protease self-immunity
NLK52_11310	COG0514	ATP-dependent DNA helicase (RecQ)
NLK52_11315	COG4955	Helix-turn-helix domain
NLK52_11320	COG1141	Ferredoxin
NLK52_11325	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
NLK52_11330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NLK52_11335	COG0710	3-dehydroquinate dehydratase activity
NLK52_11345	COG1595	DNA-templated transcription, initiation
NLK52_11350	COG5002	protein histidine kinase activity
NLK52_11355	COG0745	RESPONSE REGULATOR receiver
NLK52_11360	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NLK52_11365	COG1333	cytochrome c biogenesis protein
NLK52_11370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NLK52_11375	COG1187	pseudouridine synthase activity
NLK52_11380	COG0700	Nucleoside recognition
NLK52_11385	COG2715	membrane protein required for spore maturation
NLK52_11390	COG1686	Belongs to the peptidase S11 family
NLK52_11400	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NLK52_11405	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NLK52_11410	COG1547	Domain of unknown function (DUF309)
NLK52_11415	COG0456	acetyltransferase
NLK52_11420	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NLK52_11425	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NLK52_11425	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NLK52_11430	COG0307	riboflavin synthase, alpha
NLK52_11435	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NLK52_11435	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NLK52_11445	COG0681	Belongs to the peptidase S26 family
NLK52_11455	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
NLK52_11465	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NLK52_11470	COG4086	secreted protein
NLK52_11475	COG0019	diaminopimelate decarboxylase activity
NLK52_11480	COG0697	spore germination
NLK52_11495	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NLK52_11515	COG1191	sigma factor activity
NLK52_11520	COG2172	sigma factor antagonist activity
NLK52_11525	COG1366	Belongs to the anti-sigma-factor antagonist family
NLK52_11530	COG1686	Belongs to the peptidase S11 family
NLK52_11535	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NLK52_11540	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NLK52_11545	COG4974	Belongs to the 'phage' integrase family
NLK52_11555	COG0735	belongs to the Fur family
NLK52_11560	COG1300	Membrane
NLK52_11570	COG0281	malic enzyme
NLK52_11575	COG1757	Na H antiporter
NLK52_11580	COG1027	Aspartate ammonia-lyase
NLK52_11585	COG0252	asparaginase activity
NLK52_11590	COG1396	sequence-specific DNA binding
NLK52_11595	COG1379	DNA repair
NLK52_11600	COG0494	nUDIX hydrolase
NLK52_11610	COG0667	Aldo Keto reductase
NLK52_11620	COG1073	alpha beta
NLK52_11630	COG4918	Iron-sulphur cluster biosynthesis
NLK52_11635	COG0456	acetyltransferase
NLK52_11635	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NLK52_11640	COG2329	Antibiotic biosynthesis monooxygenase
NLK52_11645	COG0456	acetyltransferase
NLK52_11655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NLK52_11665	COG2211	Major facilitator Superfamily
NLK52_11675	COG0346	lactoylglutathione lyase activity
NLK52_11680	COG1072	(Pantothenic acid kinase))
NLK52_11685	COG3048	D-serine ammonia-lyase activity
NLK52_11690	COG0300	oxidoreductase activity
NLK52_11695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NLK52_11700	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NLK52_11705	COG4187	Peptidase family M20/M25/M40
NLK52_11710	COG1902	pentaerythritol trinitrate reductase activity
NLK52_11715	COG0596	Alpha beta hydrolase
NLK52_11725	COG1234	tRNA 3'-trailer cleavage
NLK52_11730	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NLK52_11735	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NLK52_11740	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NLK52_11750	COG0706	membrane insertase activity
NLK52_11755	COG3361	conserved protein (COG2071)
NLK52_11760	COG2195	Cleaves the N-terminal amino acid of tripeptides
NLK52_11765	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NLK52_11770	COG0346	lactoylglutathione lyase activity
NLK52_11780	COG1376	ErfK ybiS ycfS ynhG family protein
NLK52_11785	COG4129	membrane
NLK52_11790	COG1126	abc transporter atp-binding protein
NLK52_11795	COG0765	amino acid transport
NLK52_11800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NLK52_11810	COG1597	lipid kinase activity
NLK52_11815	COG2814	Major facilitator Superfamily
NLK52_11820	COG0789	Transcriptional regulator
NLK52_11820	COG4978	Transcriptional regulator
NLK52_11825	COG0508	dehydrogenase complex catalyzes the overall conversion of
NLK52_11830	COG0022	dehydrogenase e1 component
NLK52_11835	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NLK52_11840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NLK52_11845	COG3426	butyrate kinase activity
NLK52_11850	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NLK52_11855	COG0280	phosphate acetyltransferase
NLK52_11860	COG3829	transcription factor binding
NLK52_11860	COG3290	protein histidine kinase activity
NLK52_11870	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NLK52_11875	COG2079	MmgE PrpD family protein
NLK52_11880	COG0372	Belongs to the citrate synthase family
NLK52_11885	COG1960	acyl-CoA dehydrogenase activity
NLK52_11890	COG1250	3-hydroxyacyl-CoA dehydrogenase
NLK52_11895	COG0183	Belongs to the thiolase family
NLK52_11900	COG0584	glycerophosphoryl diester phosphodiesterase
NLK52_11905	COG0860	N-Acetylmuramoyl-L-alanine amidase
NLK52_11920	COG1902	pentaerythritol trinitrate reductase activity
NLK52_11925	COG0745	RESPONSE REGULATOR receiver
NLK52_11930	COG0750	zinc metalloprotease
NLK52_11935	COG0497	DNA recombination
NLK52_11940	COG1438	arginine binding
NLK52_11945	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
NLK52_11950	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NLK52_11955	COG0142	geranyltranstransferase activity
NLK52_11960	COG1722	exodeoxyribonuclease VII activity
NLK52_11965	COG1570	exodeoxyribonuclease VII activity
NLK52_11970	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NLK52_11975	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NLK52_11980	COG1302	Protein conserved in bacteria
NLK52_11985	COG0439	Biotin carboxylase
NLK52_11990	COG0511	ligase activity, forming carbon-carbon bonds
NLK52_12030	COG3854	ATPases associated with a variety of cellular activities
NLK52_12040	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NLK52_12045	COG0006	proline dipeptidase activity
NLK52_12050	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NLK52_12060	COG3872	metal-dependent enzyme
NLK52_12070	COG1752	Esterase of the alpha-beta hydrolase superfamily
NLK52_12075	COG1321	iron dependent repressor
NLK52_12080	COG0095	Lipoate-protein ligase
NLK52_12085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NLK52_12090	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NLK52_12095	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NLK52_12100	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NLK52_12105	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NLK52_12120	COG1396	sequence-specific DNA binding
NLK52_12130	COG0681	Belongs to the peptidase S26 family
NLK52_12155	COG4940	Competence protein ComGF
NLK52_12165	COG4970	Tfp pilus assembly protein FimT
NLK52_12170	COG4537	Required for transformation and DNA binding
NLK52_12175	COG1459	type II secretion system
NLK52_12180	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NLK52_12185	COG0598	Magnesium transport protein CorA
NLK52_12190	COG1253	flavin adenine dinucleotide binding
NLK52_12195	COG1366	Belongs to the anti-sigma-factor antagonist family
NLK52_12205	COG1393	Belongs to the ArsC family
NLK52_12215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NLK52_12225	COG0011	TIGRFAM Protein of
NLK52_12235	COG2866	Carboxypeptidase
NLK52_12240	COG1368	sulfuric ester hydrolase activity
NLK52_12245	COG1940	carbohydrate kinase activity
NLK52_12250	COG4483	Protein conserved in bacteria
NLK52_12255	COG0705	Rhomboid family
NLK52_12255	COG0457	Tetratricopeptide repeat
NLK52_12265	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NLK52_12275	COG0438	transferase activity, transferring glycosyl groups
NLK52_12290	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NLK52_12295	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NLK52_12300	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NLK52_12305	COG0581	inorganic phosphate transmembrane transporter activity
NLK52_12310	COG0573	inorganic phosphate transmembrane transporter activity
NLK52_12315	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NLK52_12320	COG0768	penicillin binding
NLK52_12325	COG0477	Major facilitator Superfamily
NLK52_12330	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NLK52_12335	COG2839	Protein conserved in bacteria
NLK52_12340	COG5521	maltodextrose utilization protein MalA
NLK52_12345	COG1388	LysM domain
NLK52_12350	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NLK52_12355	COG4709	membrane
NLK52_12360	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
NLK52_12365	COG0735	belongs to the Fur family
NLK52_12370	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NLK52_12380	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NLK52_12385	COG0513	Belongs to the DEAD box helicase family
NLK52_12395	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NLK52_12400	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NLK52_12405	COG2384	SAM-dependent methyltransferase
NLK52_12410	COG2010	Cytochrome c
NLK52_12415	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NLK52_12420	COG0358	DNA primase activity
NLK52_12425	COG1671	Belongs to the UPF0178 family
NLK52_12430	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NLK52_12435	COG0517	IMP dehydrogenase activity
NLK52_12440	COG0751	glycine-tRNA ligase activity
NLK52_12445	COG0752	glycyl-tRNA synthetase alpha subunit
NLK52_12450	COG1381	Involved in DNA repair and RecF pathway recombination
NLK52_12460	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NLK52_12465	COG0295	cytidine deaminase activity
NLK52_12470	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NLK52_12475	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NLK52_12480	COG1480	7TM receptor with intracellular HD hydrolase
NLK52_12485	COG1702	phosphate starvation-inducible protein PhoH
NLK52_12490	COG0561	phosphatase activity
NLK52_12505	COG4864	UPF0365 protein
NLK52_12510	COG1030	water channel activity
NLK52_12515	COG1610	YqeY-like protein
NLK52_12525	COG1283	sodium-dependent phosphate transmembrane transporter activity
NLK52_12530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NLK52_12535	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NLK52_12540	COG2264	protein methyltransferase activity
NLK52_12545	COG0484	heat shock protein binding
NLK52_12550	COG0443	Heat shock 70 kDa protein
NLK52_12555	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NLK52_12560	COG1420	regulation of RNA biosynthetic process
NLK52_12565	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NLK52_12570	COG0481	GTPase activity
NLK52_12580	COG0860	N-Acetylmuramoyl-L-alanine amidase
NLK52_12585	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NLK52_12590	COG0268	Binds directly to 16S ribosomal RNA
NLK52_12595	COG1466	dna polymerase III delta subunit
NLK52_12610	COG2333	competence protein COMEC
NLK52_12610	COG0658	competence protein
NLK52_12615	COG2131	deaminase
NLK52_12620	COG1596	polysaccharide export
NLK52_12620	COG1555	photosystem II stabilization
NLK52_12625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NLK52_12630	COG2226	methyltransferase
NLK52_12635	COG0799	negative regulation of ribosome biogenesis
NLK52_12640	COG1713	HD superfamily hydrolase involved in NAD metabolism
NLK52_12645	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NLK52_12650	COG1534	Rna-binding protein
NLK52_12655	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NLK52_12660	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NLK52_12665	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
NLK52_12675	COG2755	lipolytic protein G-D-S-L family
NLK52_12680	COG3409	Peptidoglycan-binding domain 1 protein
NLK52_12680	COG5632	N-Acetylmuramoyl-L-alanine amidase
NLK52_12685	COG0398	Pfam SNARE associated Golgi protein
NLK52_12690	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NLK52_12700	COG3209	COG3209 Rhs family protein
NLK52_12720	COG3223	Belongs to the PsiE family
NLK52_12725	COG5002	protein histidine kinase activity
NLK52_12725	COG0642	Histidine kinase
NLK52_12730	COG0745	RESPONSE REGULATOR receiver
NLK52_12735	COG2311	Membrane
NLK52_12740	COG0454	-acetyltransferase
NLK52_12745	COG1733	regulation of RNA biosynthetic process
NLK52_12750	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_12785	COG4824	toxin secretion phage lysis holin
NLK52_12805	COG0563	adenylate kinase activity
NLK52_12830	COG2249	NAD(P)H dehydrogenase (quinone) activity
NLK52_12840	COG1846	Transcriptional regulator
NLK52_12845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NLK52_12855	COG0457	Tetratricopeptide repeat
NLK52_12860	COG5444	nuclease activity
NLK52_12885	COG0789	Transcriptional regulator
NLK52_12885	COG4978	Transcriptional regulator
NLK52_12890	COG2814	Major facilitator Superfamily
NLK52_12895	COG0456	acetyltransferase
NLK52_12900	COG1253	flavin adenine dinucleotide binding
NLK52_12910	COG0697	spore germination
NLK52_12915	COG0583	DNA-binding transcription factor activity
NLK52_12920	COG2072	flavoprotein involved in K transport
NLK52_12925	COG1230	cation diffusion facilitator family transporter
NLK52_12930	COG1942	4-Oxalocrotonate Tautomerase
NLK52_12935	COG0583	DNA-binding transcription factor activity
NLK52_12945	COG1114	Component of the transport system for branched-chain amino acids
NLK52_12950	COG1687	branched-chain amino acid
NLK52_12955	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NLK52_12960	COG1522	sequence-specific DNA binding
NLK52_12970	COG2124	cytochrome p450
NLK52_12980	COG1335	isochorismatase
NLK52_13000	COG2318	DinB family
NLK52_13010	COG2070	2-Nitropropane dioxygenase
NLK52_13015	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NLK52_13035	COG3443	Belongs to the bacterial solute-binding protein 9 family
NLK52_13040	COG1595	DNA-templated transcription, initiation
NLK52_13045	COG0667	Aldo Keto reductase
NLK52_13050	COG3409	Peptidoglycan-binding domain 1 protein
NLK52_13055	COG5566	PFAM Mor transcription activator
NLK52_13060	COG0596	Alpha beta hydrolase
NLK52_13065	COG4991	sh3 domain protein
NLK52_13070	COG4991	sh3 domain protein
NLK52_13080	COG0346	lactoylglutathione lyase activity
NLK52_13090	COG5577	PFAM Coat F domain
NLK52_13095	COG1063	alcohol dehydrogenase
NLK52_13105	COG5577	PFAM Coat F domain
NLK52_13110	COG0789	Transcriptional regulator
NLK52_13120	COG1064	alcohol dehydrogenase
NLK52_13125	COG0693	protein deglycase activity
NLK52_13130	COG1621	beta-fructofuranosidase activity
NLK52_13140	COG3716	PTS system mannose fructose sorbose family IID component
NLK52_13145	COG3715	PTS system
NLK52_13150	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NLK52_13155	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
NLK52_13160	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NLK52_13160	COG3933	PFAM sigma-54 factor interaction domain-containing protein
NLK52_13170	COG1113	amino acid transport
NLK52_13175	COG1280	lysine exporter protein (LysE YggA)
NLK52_13180	COG1378	Sugar-specific transcriptional regulator TrmB
NLK52_13185	COG1595	DNA-templated transcription, initiation
NLK52_13195	COG2755	lipolytic protein G-D-S-L family
NLK52_13195	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NLK52_13205	COG2124	cytochrome p450
NLK52_13205	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NLK52_13210	COG1309	transcriptional regulator
NLK52_13215	COG2226	methyltransferase
NLK52_13230	COG2116	formate transmembrane transporter activity
NLK52_13235	COG5609	conserved protein (DUF2294)
NLK52_13240	COG3383	formate dehydrogenase (NAD+) activity
NLK52_13245	COG2427	Protein of unknown function (DUF1641)
NLK52_13255	COG0626	cystathionine gamma-synthase activity
NLK52_13260	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NLK52_13265	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NLK52_13270	COG2226	methyltransferase
NLK52_13285	COG0768	penicillin binding
NLK52_13290	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NLK52_13295	COG0572	uridine kinase
NLK52_13300	COG0826	peptidase U32
NLK52_13305	COG0826	peptidase U32
NLK52_13310	COG4122	O-methyltransferase activity
NLK52_13315	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NLK52_13320	COG3906	Belongs to the UPF0473 family
NLK52_13325	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NLK52_13330	COG4472	Bacterial protein of unknown function (DUF965)
NLK52_13335	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NLK52_13340	COG0628	permease
NLK52_13345	COG1126	abc transporter atp-binding protein
NLK52_13350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NLK52_13355	COG0765	amino acid transport
NLK52_13360	COG0765	amino acid transport
NLK52_13375	COG3881	PFAM PRC-barrel domain
NLK52_13380	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NLK52_13385	COG0457	Tetratricopeptide repeat
NLK52_13390	COG0482	sulfurtransferase activity
NLK52_13395	COG1104	cysteine desulfurase activity
NLK52_13400	COG1959	2 iron, 2 sulfur cluster binding
NLK52_13405	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NLK52_13410	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NLK52_13420	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NLK52_13425	COG0124	histidyl-tRNA synthetase
NLK52_13435	COG3103	Sh3 type 3 domain protein
NLK52_13435	COG4991	sh3 domain protein
NLK52_13435	COG0860	N-Acetylmuramoyl-L-alanine amidase
NLK52_13440	COG1490	D-aminoacyl-tRNA deacylase activity
NLK52_13445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NLK52_13450	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NLK52_13455	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NLK52_13455	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NLK52_13460	COG5416	Lipopolysaccharide assembly protein A domain
NLK52_13465	COG0490	domain, Protein
NLK52_13470	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NLK52_13470	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NLK52_13480	COG2244	polysaccharide biosynthetic process
NLK52_13485	COG2323	membrane
NLK52_13495	COG1862	Preprotein translocase
NLK52_13500	COG0343	queuine tRNA-ribosyltransferase activity
NLK52_13505	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NLK52_13515	COG2255	four-way junction helicase activity
NLK52_13520	COG0632	four-way junction helicase activity
NLK52_13530	COG2814	Major facilitator Superfamily
NLK52_13535	COG0673	inositol 2-dehydrogenase activity
NLK52_13540	COG2112	serine threonine protein kinase
NLK52_13560	COG1115	amino acid carrier protein
NLK52_13565	COG0217	transcriptional regulatory protein
NLK52_13575	COG1388	LysM domain
NLK52_13580	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NLK52_13585	COG0157	Belongs to the NadC ModD family
NLK52_13590	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NLK52_13595	COG1104	cysteine desulfurase activity
NLK52_13600	COG1827	regulation of RNA biosynthetic process
NLK52_13605	COG0077	Prephenate dehydratase
NLK52_13610	COG4492	Belongs to the UPF0735 family
NLK52_13615	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NLK52_13620	COG3290	protein histidine kinase activity
NLK52_13630	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NLK52_13635	COG2868	ribosomal protein
NLK52_13640	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NLK52_13645	COG1994	Peptidase M50
NLK52_13650	COG0739	heme binding
NLK52_13655	COG2894	cell division
NLK52_13660	COG0850	regulation of cytokinetic process
NLK52_13665	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NLK52_13675	COG1077	Cell shape determining protein MreB Mrl
NLK52_13680	COG2003	Belongs to the UPF0758 family
NLK52_13685	COG0424	maF-like protein
NLK52_13695	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NLK52_13700	COG0285	dihydrofolate synthase activity
NLK52_13705	COG0525	valine-tRNA ligase activity
NLK52_13715	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NLK52_13720	COG1388	LysM domain
NLK52_13725	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NLK52_13730	COG0113	porphobilinogen synthase activity
NLK52_13735	COG1587	Uroporphyrinogen-III synthase
NLK52_13740	COG0181	hydroxymethylbilane synthase activity
NLK52_13745	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NLK52_13750	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NLK52_13760	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NLK52_13765	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NLK52_13770	COG1067	ATP-dependent peptidase activity
NLK52_13770	COG0470	DNA polymerase III
NLK52_13775	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NLK52_13780	COG0544	peptidyl-prolyl cis-trans isomerase activity
NLK52_13785	COG0457	Tetratricopeptide repeat
NLK52_13785	COG1477	protein flavinylation
NLK52_13790	COG0066	3-isopropylmalate dehydratase activity
NLK52_13795	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NLK52_13800	COG0473	3-isopropylmalate dehydrogenase activity
NLK52_13805	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NLK52_13810	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NLK52_13815	COG0440	acetolactate synthase activity
NLK52_13820	COG0028	Belongs to the TPP enzyme family
NLK52_13830	COG0454	-acetyltransferase
NLK52_13835	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
NLK52_13845	COG0622	Phosphoesterase
NLK52_13850	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NLK52_13855	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NLK52_13860	COG5401	PFAM Sporulation and spore germination
NLK52_13865	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NLK52_13870	COG1846	Transcriptional regulator
NLK52_13875	COG2197	response regulator
NLK52_13880	COG0824	Thioesterase
NLK52_13885	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NLK52_13890	COG1053	succinate dehydrogenase
NLK52_13895	COG2009	succinate dehydrogenase
NLK52_13900	COG1719	4-vinyl reductase, 4VR
NLK52_13905	COG0527	aspartate kinase activity
NLK52_13910	COG0322	excinuclease ABC activity
NLK52_13915	COG3118	belongs to the thioredoxin family
NLK52_13920	COG3534	alpha-L-arabinofuranosidase
NLK52_13925	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NLK52_13930	COG2086	electron transfer activity
NLK52_13935	COG1024	Enoyl-CoA hydratase
NLK52_13940	COG1309	transcriptional regulator
NLK52_13945	COG0318	PFAM AMP-dependent synthetase and ligase
NLK52_13950	COG3766	membrane
NLK52_13955	COG1193	negative regulation of DNA recombination
NLK52_13960	COG1796	DNA polymerase
NLK52_13960	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NLK52_13965	COG1286	toxin biosynthetic process
NLK52_13970	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
NLK52_13975	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NLK52_13980	COG0072	phenylalanine-tRNA ligase activity
NLK52_13980	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NLK52_13985	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NLK52_13995	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NLK52_14005	COG3835	regulator
NLK52_14010	COG0277	FAD linked oxidase domain protein
NLK52_14015	COG0247	lactate metabolic process
NLK52_14020	COG0346	lactoylglutathione lyase activity
NLK52_14030	COG1966	Carbon starvation protein
NLK52_14035	COG3534	alpha-L-arabinofuranosidase
NLK52_14040	COG0395	ABC-type sugar transport system, permease component
NLK52_14045	COG1175	transmembrane transport
NLK52_14050	COG1653	transport
NLK52_14055	COG0371	Dehydrogenase
NLK52_14060	COG0647	UMP catabolic process
NLK52_14065	COG0235	Class ii aldolase
NLK52_14075	COG2160	L-arabinose isomerase activity
NLK52_14080	COG3507	Belongs to the glycosyl hydrolase 43 family
NLK52_14085	COG1363	Peptidase, m42
NLK52_14095	COG3326	Membrane
NLK52_14100	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NLK52_14105	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NLK52_14110	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NLK52_14120	COG1346	cytolysis
NLK52_14125	COG1380	Effector of murein hydrolase LrgA
NLK52_14130	COG3279	Response regulator of the LytR AlgR family
NLK52_14135	COG3275	phosphorelay sensor kinase activity
NLK52_14140	COG1011	Hydrolase
NLK52_14145	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NLK52_14155	COG0398	Pfam SNARE associated Golgi protein
NLK52_14160	COG1484	DNA-dependent DNA replication
NLK52_14165	COG3611	Membrane attachment protein
NLK52_14170	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NLK52_14175	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
NLK52_14180	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NLK52_14185	COG1733	regulation of RNA biosynthetic process
NLK52_14190	COG2814	Major facilitator Superfamily
NLK52_14195	COG0656	L-ascorbic acid biosynthetic process
NLK52_14200	COG0237	dephospho-CoA kinase activity
NLK52_14205	COG1971	Probably functions as a manganese efflux pump
NLK52_14210	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NLK52_14215	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NLK52_14215	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NLK52_14220	COG5002	protein histidine kinase activity
NLK52_14225	COG0745	RESPONSE REGULATOR receiver
NLK52_14230	COG0039	L-malate dehydrogenase activity
NLK52_14235	COG0538	isocitrate dehydrogenase activity
NLK52_14240	COG0372	Belongs to the citrate synthase family
NLK52_14245	COG2707	UPF0756 membrane protein
NLK52_14250	COG0628	permease
NLK52_14255	COG3030	protein affecting phage T7 exclusion by the F plasmid
NLK52_14260	COG0469	pyruvate kinase activity
NLK52_14265	COG0205	6-phosphofructokinase activity
NLK52_14270	COG0825	malonyl-CoA metabolic process
NLK52_14275	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NLK52_14280	COG0281	malic enzyme
NLK52_14285	COG0587	DNA-directed DNA polymerase activity
NLK52_14305	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NLK52_14315	COG4109	DRTGG domain
NLK52_14320	COG0730	response to heat
NLK52_14325	COG1473	amidohydrolase
NLK52_14330	COG0196	riboflavin kinase activity
NLK52_14335	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NLK52_14345	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NLK52_14350	COG1126	abc transporter atp-binding protein
NLK52_14355	COG0765	amino acid transport
NLK52_14360	COG0765	amino acid transport
NLK52_14365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NLK52_14370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NLK52_14375	COG0454	-acetyltransferase
NLK52_14380	COG0583	DNA-binding transcription factor activity
NLK52_14385	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NLK52_14390	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_14395	COG0165	Argininosuccinate lyase
NLK52_14400	COG0137	argininosuccinate synthase activity
NLK52_14405	COG0521	Mo-molybdopterin cofactor biosynthetic process
NLK52_14410	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NLK52_14420	COG0827	DNA restriction-modification system
NLK52_14425	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NLK52_14430	COG3874	Sporulation protein YtfJ
NLK52_14440	COG1714	RDD family
NLK52_14445	COG0616	signal peptide processing
NLK52_14450	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NLK52_14455	COG1574	metal-dependent hydrolase with the TIM-barrel fold
NLK52_14460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NLK52_14470	COG0301	tRNA thio-modification
NLK52_14475	COG1104	cysteine desulfurase activity
NLK52_14480	COG1114	Component of the transport system for branched-chain amino acids
NLK52_14485	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
NLK52_14490	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NLK52_14495	COG1309	transcriptional regulator
NLK52_14500	COG1956	GAF domain-containing protein
NLK52_14505	COG2199	diguanylate cyclase activity
NLK52_14505	COG2203	Gaf domain
NLK52_14510	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NLK52_14515	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NLK52_14520	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NLK52_14525	COG0454	-acetyltransferase
NLK52_14530	COG0517	IMP dehydrogenase activity
NLK52_14535	COG0123	including yeast histone deacetylase and acetoin utilization protein
NLK52_14540	COG1360	Flagellar Motor Protein
NLK52_14545	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NLK52_14550	COG1609	Transcriptional regulator
NLK52_14555	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NLK52_14555	COG1605	Chorismate mutase
NLK52_14560	COG3118	belongs to the thioredoxin family
NLK52_14565	COG4980	gas vesicle protein
NLK52_14570	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
NLK52_14575	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NLK52_14580	COG1674	ftsk spoiiie
NLK52_14585	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NLK52_14590	COG4848	Belongs to the UPF0354 family
NLK52_14595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NLK52_14610	COG1363	Peptidase, m42
NLK52_14615	COG5584	Small secreted protein
NLK52_14620	COG0281	malic enzyme
NLK52_14625	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NLK52_14630	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NLK52_14640	COG0510	thiamine kinase activity
NLK52_14645	COG1523	belongs to the glycosyl hydrolase 13 family
NLK52_14650	COG1597	lipid kinase activity
NLK52_14660	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NLK52_14665	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NLK52_14670	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NLK52_14675	COG2252	PERMEase
NLK52_14680	COG4473	ABC transporter
NLK52_14685	COG1131	(ABC) transporter
NLK52_14690	COG1349	DNA-binding transcription factor activity
NLK52_14695	COG1187	pseudouridine synthase activity
NLK52_14700	COG2244	polysaccharide biosynthetic process
NLK52_14705	COG2081	HI0933 family
NLK52_14710	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NLK52_14720	COG5578	integral membrane protein
NLK52_14725	COG0673	inositol 2-dehydrogenase activity
NLK52_14730	COG1653	transport
NLK52_14735	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NLK52_14740	COG4209	transmembrane transport
NLK52_14745	COG2207	Transcriptional regulator
NLK52_14750	COG1653	transport
NLK52_14755	COG0395	ABC-type sugar transport system, permease component
NLK52_14760	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NLK52_14765	COG2124	cytochrome p450
NLK52_14770	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NLK52_14780	COG0156	8-amino-7-oxononanoate synthase activity
NLK52_14785	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NLK52_14795	COG1073	alpha beta
NLK52_14800	COG1609	Transcriptional regulator
NLK52_14805	COG1653	transport
NLK52_14810	COG1175	transmembrane transport
NLK52_14815	COG0395	ABC-type sugar transport system, permease component
NLK52_14820	COG1486	melibiose metabolic process
NLK52_14825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NLK52_14830	COG0495	leucyl-tRNA aminoacylation
NLK52_14840	COG2202	Pas domain
NLK52_14840	COG1366	Belongs to the anti-sigma-factor antagonist family
NLK52_14845	COG2814	Major facilitator Superfamily
NLK52_14850	COG2433	Pfam Transposase IS66
NLK52_14855	COG0577	efflux transmembrane transporter activity
NLK52_14860	COG1136	(ABC) transporter
NLK52_14865	COG2205	protein histidine kinase activity
NLK52_14870	COG0745	RESPONSE REGULATOR receiver
NLK52_14875	COG0577	efflux transmembrane transporter activity
NLK52_14880	COG1136	(ABC) transporter
NLK52_14895	COG1131	(ABC) transporter
NLK52_14900	COG1725	Transcriptional regulator
NLK52_14915	COG1242	4 iron, 4 sulfur cluster binding
NLK52_14920	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
NLK52_14930	COG2267	carboxylic ester hydrolase activity
NLK52_14935	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NLK52_14940	COG1113	amino acid transport
NLK52_14945	COG0367	asparagine synthase
NLK52_14950	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NLK52_14955	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NLK52_14965	COG1506	peptidase
NLK52_14970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NLK52_14975	COG1116	anion transmembrane transporter activity
NLK52_14980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NLK52_14985	COG0494	nUDIX hydrolase
NLK52_14990	COG4824	toxin secretion phage lysis holin
NLK52_14995	COG0783	Belongs to the Dps family
NLK52_15010	COG1854	S-ribosylhomocysteine lyase activity
NLK52_15015	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NLK52_15020	COG0288	reversible hydration of carbon dioxide
NLK52_15025	COG0254	rRNA binding
NLK52_15030	COG1271	oxidase subunit
NLK52_15035	COG1294	oxidase, subunit
NLK52_15045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NLK52_15050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NLK52_15050	COG1321	iron dependent repressor
NLK52_15055	COG1121	(ABC) transporter
NLK52_15060	COG0803	Belongs to the bacterial solute-binding protein 9 family
NLK52_15065	COG4948	Mandelate Racemase Muconate Lactonizing
NLK52_15070	COG0318	PFAM AMP-dependent synthetase and ligase
NLK52_15075	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NLK52_15080	COG0596	Alpha beta hydrolase
NLK52_15085	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NLK52_15090	COG1169	isochorismate synthase
NLK52_15095	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NLK52_15100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NLK52_15105	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NLK52_15110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NLK52_15115	COG0438	transferase activity, transferring glycosyl groups
NLK52_15125	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NLK52_15130	COG0438	transferase activity, transferring glycosyl groups
NLK52_15135	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NLK52_15140	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
NLK52_15145	COG0058	SHG alpha-glucan phosphorylase activity
NLK52_15150	COG0297	glycogen (starch) synthase activity
NLK52_15155	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NLK52_15160	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NLK52_15165	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NLK52_15290	COG3859	Proton-coupled thiamine transporter YuaJ
NLK52_15300	COG2268	Band 7 protein
NLK52_15305	COG1585	Membrane protein implicated in regulation of membrane protease activity
NLK52_15310	COG2318	DinB family
NLK52_15320	COG1454	alcohol dehydrogenase
NLK52_15325	COG1012	belongs to the aldehyde dehydrogenase family
NLK52_15330	COG1510	regulation of RNA biosynthetic process
NLK52_15340	COG0569	domain protein
NLK52_15345	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NLK52_15350	COG4682	membrane
NLK52_15355	COG1705	Flagellar rod assembly protein muramidase FlgJ
NLK52_15365	COG5553	Cysteine dioxygenase type I
NLK52_15375	COG1968	undecaprenyl-diphosphatase activity
NLK52_15380	COG0628	permease
NLK52_15385	COG0673	inositol 2-dehydrogenase activity
NLK52_15390	COG4806	L-rhamnose isomerase
NLK52_15395	COG3254	rhamnose metabolic process
NLK52_15400	COG1070	Carbohydrate kinase
NLK52_15405	COG1349	DNA-binding transcription factor activity
NLK52_15410	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_15410	COG3347	Dehydrogenase
NLK52_15415	COG0840	transmembrane signaling receptor activity
NLK52_15420	COG0840	transmembrane signaling receptor activity
NLK52_15425	COG0840	transmembrane signaling receptor activity
NLK52_15430	COG0840	transmembrane signaling receptor activity
NLK52_15450	COG0432	Pfam Uncharacterised protein family UPF0047
NLK52_15455	COG0366	Alpha amylase catalytic
NLK52_15460	COG1253	flavin adenine dinucleotide binding
NLK52_15465	COG2738	Putative neutral zinc metallopeptidase
NLK52_15480	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NLK52_15495	COG0166	Belongs to the GPI family
NLK52_15500	COG1979	alcohol dehydrogenase
NLK52_15505	COG1979	alcohol dehydrogenase
NLK52_15510	COG2155	Conserved Protein
NLK52_15515	COG1098	S1 RNA binding domain
NLK52_15520	COG0436	Aminotransferase
NLK52_15525	COG1522	sequence-specific DNA binding
NLK52_15530	COG2267	carboxylic ester hydrolase activity
NLK52_15540	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NLK52_15545	COG2205	protein histidine kinase activity
NLK52_15555	COG5018	Exonuclease
NLK52_15565	COG2814	Major facilitator Superfamily
NLK52_15570	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NLK52_15575	COG3011	Protein conserved in bacteria
NLK52_15585	COG3290	protein histidine kinase activity
NLK52_15590	COG4565	transcriptional regulatory protein
NLK52_15595	COG1744	ABC transporter substrate-binding protein PnrA-like
NLK52_15600	COG3845	ABC transporter
NLK52_15605	COG4603	Belongs to the binding-protein-dependent transport system permease family
NLK52_15610	COG1079	Belongs to the binding-protein-dependent transport system permease family
NLK52_15615	COG3493	citrate carrier protein
NLK52_15625	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NLK52_15625	COG2111	Na H antiporter
NLK52_15630	COG2111	Na H antiporter
NLK52_15635	COG1006	Multisubunit Na H antiporter MnhC subunit
NLK52_15640	COG0651	ATP synthesis coupled electron transport
NLK52_15645	COG1863	multisubunit Na H antiporter MnhE subunit
NLK52_15650	COG2212	antiporter activity
NLK52_15655	COG1320	monovalent cation:proton antiporter activity
NLK52_15660	COG2050	protein possibly involved in aromatic compounds catabolism
NLK52_15665	COG2197	response regulator
NLK52_15670	COG4585	Histidine kinase
NLK52_15680	COG0142	geranyltranstransferase activity
NLK52_15700	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NLK52_15705	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NLK52_15710	COG1335	isochorismatase
NLK52_15715	COG5506	Protein of unknown function (DUF1694)
NLK52_15730	COG0628	permease
NLK52_15745	COG1418	mRNA catabolic process
NLK52_15750	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_15760	COG1511	domain protein
NLK52_15765	COG0433	COG0433 Predicted ATPase
NLK52_15765	COG1674	ftsk spoiiie
NLK52_15770	COG4499	WXG100 protein secretion system (Wss), protein YukC
NLK52_15775	COG5417	Belongs to the EsaB family
NLK52_15780	COG4842	Belongs to the WXG100 family
NLK52_15785	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NLK52_15785	COG2508	Transcriptional regulator
NLK52_15790	COG0686	Belongs to the AlaDH PNT family
NLK52_15795	COG5634	Uncharacterized conserved protein (DUF2278)
NLK52_15800	COG3251	PFAM MbtH domain protein
NLK52_15805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NLK52_15810	COG3433	isochorismatase activity
NLK52_15810	COG1535	isochorismatase
NLK52_15815	COG1021	2,3-dihydroxybenzoate-AMP ligase
NLK52_15820	COG1169	isochorismate synthase
NLK52_15825	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_15830	COG2819	hydrolase of the alpha beta superfamily
NLK52_15835	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NLK52_15840	COG1268	BioY protein
NLK52_15845	COG2056	Na+-H+ antiporter family
NLK52_15850	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NLK52_15855	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
NLK52_15860	COG3584	3D domain protein
NLK52_15875	COG1252	NADH dehydrogenase
NLK52_15880	COG0492	ferredoxin-NADP+ reductase activity
NLK52_15890	COG0516	GMP reductase activity
NLK52_15895	COG2808	Putative FMN-binding domain
NLK52_15900	COG0456	acetyltransferase
NLK52_15905	COG0316	Belongs to the HesB IscA family
NLK52_15910	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NLK52_15915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NLK52_15920	COG4844	belongs to the
NLK52_15925	COG1252	NADH dehydrogenase
NLK52_15930	COG4837	Protein of unknown function (DUF1462)
NLK52_15935	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NLK52_15940	COG4946	Tricorn protease homolog
NLK52_15940	COG0823	Involved in the tonB-independent uptake of proteins
NLK52_15940	COG1506	peptidase
NLK52_15945	COG0083	homoserine kinase activity
NLK52_15950	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NLK52_15955	COG0460	homoserine dehydrogenase
NLK52_15960	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NLK52_15965	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NLK52_15970	COG0647	UMP catabolic process
NLK52_15975	COG2445	Protein of unknown function DUF86
NLK52_15980	COG4470	Protein conserved in bacteria
NLK52_15990	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NLK52_15995	COG0739	heme binding
NLK52_16005	COG3377	Domain of unknown function (DUF1805)
NLK52_16010	COG0737	Belongs to the 5'-nucleotidase family
NLK52_16015	COG0730	response to heat
NLK52_16020	COG1801	Protein of unknown function DUF72
NLK52_16030	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NLK52_16035	COG2508	Transcriptional regulator
NLK52_16040	COG2233	PERMEase
NLK52_16045	COG2233	PERMEase
NLK52_16050	COG3648	Uricase
NLK52_16050	COG3195	allantoin biosynthetic process
NLK52_16055	COG2351	hydroxyisourate hydrolase activity
NLK52_16065	COG2080	2 iron, 2 sulfur cluster binding
NLK52_16070	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NLK52_16075	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NLK52_16080	COG2068	MobA-Related Protein
NLK52_16085	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NLK52_16090	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NLK52_16095	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NLK52_16105	COG2356	endonuclease I
NLK52_16110	COG3842	ATPase activity
NLK52_16115	COG2188	Transcriptional regulator
NLK52_16120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NLK52_16125	COG0395	ABC-type sugar transport system, permease component
NLK52_16130	COG1175	transmembrane transport
NLK52_16135	COG1653	transport
NLK52_16140	COG2222	sugar isomerase
NLK52_16145	COG0322	excinuclease ABC activity
NLK52_16150	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NLK52_16165	COG0346	lactoylglutathione lyase activity
NLK52_16170	COG0640	Transcriptional regulator
NLK52_16175	COG0719	Fe-S assembly protein
NLK52_16180	COG0822	iron-sulfur transferase activity
NLK52_16185	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NLK52_16190	COG0719	Fe-S assembly protein
NLK52_16195	COG0396	ATPase activity
NLK52_16205	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NLK52_16210	COG1464	Belongs to the NlpA lipoprotein family
NLK52_16215	COG2011	ABC-type metal ion transport system permease component
NLK52_16220	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NLK52_16230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NLK52_16235	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NLK52_16245	COG0509	glycine decarboxylation via glycine cleavage system
NLK52_16250	COG1393	Belongs to the ArsC family
NLK52_16255	COG1960	acyl-CoA dehydrogenase activity
NLK52_16260	COG0183	Belongs to the thiolase family
NLK52_16265	COG1024	Enoyl-CoA hydratase
NLK52_16265	COG1250	3-hydroxyacyl-CoA dehydrogenase
NLK52_16275	COG0506	proline dehydrogenase activity
NLK52_16285	COG5577	PFAM Coat F domain
NLK52_16290	COG1846	Transcriptional regulator
NLK52_16295	COG0477	Major facilitator Superfamily
NLK52_16300	COG1942	4-Oxalocrotonate Tautomerase
NLK52_16305	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_16310	COG0583	DNA-binding transcription factor activity
NLK52_16320	COG1120	ATPase activity
NLK52_16335	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_16340	COG0783	Belongs to the Dps family
NLK52_16345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NLK52_16350	COG0745	RESPONSE REGULATOR receiver
NLK52_16355	COG2770	Histidine kinase
NLK52_16355	COG2205	protein histidine kinase activity
NLK52_16365	COG1309	transcriptional regulator
NLK52_16370	COG0114	fumarate hydratase activity
NLK52_16380	COG0697	spore germination
NLK52_16385	COG0814	amino acid
NLK52_16395	COG2197	response regulator
NLK52_16400	COG4585	Histidine kinase
NLK52_16405	COG4758	membrane
NLK52_16410	COG3595	metallopeptidase activity
NLK52_16415	COG1842	Phage shock protein A
NLK52_16420	COG4758	membrane
NLK52_16425	COG2814	Major facilitator Superfamily
NLK52_16430	COG2096	Adenosyltransferase
NLK52_16435	COG1120	ATPase activity
NLK52_16440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NLK52_16445	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NLK52_16450	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_16455	COG3386	PFAM SMP-30 Gluconolaconase
NLK52_16460	COG2205	protein histidine kinase activity
NLK52_16465	COG0745	RESPONSE REGULATOR receiver
NLK52_16475	COG1191	sigma factor activity
NLK52_16485	COG2140	Oxalate decarboxylase
NLK52_16495	COG0577	efflux transmembrane transporter activity
NLK52_16500	COG1136	(ABC) transporter
NLK52_16505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NLK52_16510	COG1120	ATPase activity
NLK52_16515	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NLK52_16520	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NLK52_16525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NLK52_16530	COG0531	amino acid
NLK52_16540	COG1988	membrane-bound metal-dependent
NLK52_16545	COG1368	sulfuric ester hydrolase activity
NLK52_16550	COG1910	domain protein
NLK52_16555	COG0725	ABC transporter, periplasmic molybdate-binding protein
NLK52_16560	COG4149	molybdate abc transporter
NLK52_16565	COG0656	L-ascorbic acid biosynthetic process
NLK52_16575	COG0025	NhaP-type Na H and K H
NLK52_16580	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NLK52_16585	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NLK52_16590	COG3973	AAA domain
NLK52_16600	COG2860	membrane
NLK52_16605	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NLK52_16610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NLK52_16615	COG2217	Heavy metal translocating P-type atpase
NLK52_16620	COG2217	Heavy metal translocating P-type atpase
NLK52_16625	COG2608	mercury ion transmembrane transporter activity
NLK52_16630	COG1937	Protein conserved in bacteria
NLK52_16635	COG0673	inositol 2-dehydrogenase activity
NLK52_16640	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NLK52_16645	COG1289	transmembrane transporter activity
NLK52_16655	COG2076	Multidrug Resistance protein
NLK52_16660	COG1309	transcriptional regulator
NLK52_16665	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_16675	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NLK52_16680	COG0557	exoribonuclease II activity
NLK52_16685	COG1647	Serine aminopeptidase, S33
NLK52_16690	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NLK52_16695	COG0596	Alpha beta hydrolase
NLK52_16700	COG1476	TRANSCRIPTIONal
NLK52_16705	COG1396	sequence-specific DNA binding
NLK52_16710	COG1396	sequence-specific DNA binding
NLK52_16715	COG1733	regulation of RNA biosynthetic process
NLK52_16740	COG1174	glycine betaine transport
NLK52_16745	COG1732	Glycine betaine
NLK52_16750	COG1174	glycine betaine transport
NLK52_16755	COG0517	IMP dehydrogenase activity
NLK52_16755	COG1125	glycine betaine transport
NLK52_16760	COG1510	regulation of RNA biosynthetic process
NLK52_16765	COG1174	glycine betaine transport
NLK52_16770	COG1732	Glycine betaine
NLK52_16775	COG1174	glycine betaine transport
NLK52_16780	COG0517	IMP dehydrogenase activity
NLK52_16780	COG1125	glycine betaine transport
NLK52_16785	COG1510	regulation of RNA biosynthetic process
NLK52_16790	COG2095	MarC family integral membrane protein
NLK52_16800	COG3064	Membrane
NLK52_16805	COG4640	response to antibiotic
NLK52_16810	COG0456	acetyltransferase
NLK52_16825	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NLK52_16845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NLK52_16850	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NLK52_16860	COG2234	aminopeptidase activity
NLK52_16865	COG0148	phosphopyruvate hydratase activity
NLK52_16870	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NLK52_16875	COG0149	triose-phosphate isomerase activity
NLK52_16880	COG0126	phosphoglycerate kinase activity
NLK52_16885	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NLK52_16890	COG2390	Transcriptional regulator
NLK52_16895	COG2814	Major facilitator Superfamily
NLK52_16900	COG1609	Transcriptional regulator
NLK52_16905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NLK52_16910	COG0583	DNA-binding transcription factor activity
NLK52_16915	COG0697	spore germination
NLK52_16920	COG1113	amino acid transport
NLK52_16925	COG3858	chitin binding
NLK52_16930	COG1556	Lactate utilization protein
NLK52_16935	COG1139	Iron-sulfur cluster binding protein
NLK52_16940	COG0247	lactate metabolic process
NLK52_16945	COG2197	response regulator
NLK52_16950	COG4585	Histidine kinase
NLK52_16955	COG0842	Transport permease protein
NLK52_16960	COG1131	(ABC) transporter
NLK52_16965	COG0596	Alpha beta hydrolase
NLK52_16970	COG2208	phosphoserine phosphatase activity
NLK52_16975	COG3867	Arabinogalactan endo-beta-1,4-galactanase
NLK52_16980	COG1874	Beta-galactosidase
NLK52_16985	COG3833	ABC-type maltose transport systems, permease component
NLK52_16990	COG1175	transmembrane transport
NLK52_16995	COG2182	Extracellular solute-binding protein
NLK52_17000	COG1609	Transcriptional regulator
NLK52_17005	COG2186	Transcriptional regulator
NLK52_17010	COG1620	l-lactate permease
NLK52_17015	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
NLK52_17025	COG5039	Polysaccharide pyruvyl transferase
NLK52_17030	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NLK52_17035	COG0110	maltose O-acetyltransferase activity
NLK52_17040	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NLK52_17045	COG2244	polysaccharide biosynthetic process
NLK52_17050	COG1216	Glycosyl transferase, family 2
NLK52_17055	COG5039	Polysaccharide pyruvyl transferase
NLK52_17060	COG1216	Glycosyl transferase, family 2
NLK52_17070	COG0438	transferase activity, transferring glycosyl groups
NLK52_17075	COG1215	transferase activity, transferring glycosyl groups
NLK52_17080	COG0438	transferase activity, transferring glycosyl groups
NLK52_17085	COG1086	Polysaccharide biosynthesis protein
NLK52_17090	COG0489	protein tyrosine kinase activity
NLK52_17095	COG3944	biosynthesis protein
NLK52_17100	COG1396	sequence-specific DNA binding
NLK52_17105	COG2272	Belongs to the type-B carboxylesterase lipase family
NLK52_17115	COG3479	Phenolic acid decarboxylase
NLK52_17125	COG1794	racemase activity, acting on amino acids and derivatives
NLK52_17140	COG1621	beta-fructofuranosidase activity
NLK52_17145	COG1621	beta-fructofuranosidase activity
NLK52_17150	COG0531	amino acid
NLK52_17155	COG1309	transcriptional regulator
NLK52_17160	COG2076	Multidrug Resistance protein
NLK52_17165	COG2076	Multidrug Resistance protein
NLK52_17200	COG0740	serine-type endopeptidase activity
NLK52_17205	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NLK52_17210	COG0366	Alpha amylase catalytic
NLK52_17215	COG1554	hydrolase, family 65, central catalytic
NLK52_17220	COG5521	maltodextrose utilization protein MalA
NLK52_17225	COG3833	ABC-type maltose transport systems, permease component
NLK52_17230	COG1175	transmembrane transport
NLK52_17235	COG2182	Extracellular solute-binding protein
NLK52_17240	COG0366	Alpha amylase catalytic
NLK52_17245	COG1609	Transcriptional regulator
NLK52_17250	COG1611	Belongs to the LOG family
NLK52_17255	COG1694	Mazg nucleotide pyrophosphohydrolase
NLK52_17260	COG0659	secondary active sulfate transmembrane transporter activity
NLK52_17265	COG0288	reversible hydration of carbon dioxide
NLK52_17270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NLK52_17275	COG0577	efflux transmembrane transporter activity
NLK52_17280	COG1136	(ABC) transporter
NLK52_17285	COG5002	protein histidine kinase activity
NLK52_17290	COG0745	RESPONSE REGULATOR receiver
NLK52_17300	COG2162	N-hydroxyarylamine O-acetyltransferase activity
NLK52_17305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NLK52_17310	COG1481	regulation of sporulation
NLK52_17315	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NLK52_17320	COG1660	Displays ATPase and GTPase activities
NLK52_17325	COG1051	belongs to the nudix hydrolase family
NLK52_17330	COG0492	ferredoxin-NADP+ reductase activity
NLK52_17335	COG3883	PFAM NLP P60 protein
NLK52_17335	COG0791	NLP P60 protein
NLK52_17340	COG0457	Tetratricopeptide repeat
NLK52_17345	COG1132	(ABC) transporter
NLK52_17365	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NLK52_17365	COG0140	phosphoribosyl-ATP diphosphatase activity
NLK52_17370	COG0107	imidazoleglycerol-phosphate synthase activity
NLK52_17375	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NLK52_17380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NLK52_17385	COG0131	Imidazoleglycerol-phosphate dehydratase
NLK52_17390	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NLK52_17395	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NLK52_17400	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
NLK52_17405	COG4990	cell redox homeostasis
NLK52_17410	COG5297	Belongs to the glycosyl hydrolase family 6
NLK52_17415	COG0110	maltose O-acetyltransferase activity
NLK52_17420	COG0546	phosphoglycolate phosphatase activity
NLK52_17425	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
NLK52_17430	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NLK52_17435	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
NLK52_17440	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NLK52_17445	COG0363	glucosamine-6-phosphate deaminase activity
NLK52_17450	COG2188	Transcriptional regulator
NLK52_17455	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NLK52_17460	COG1950	PFAM Membrane protein of
NLK52_17465	COG1983	PspC domain protein
NLK52_17470	COG3595	metallopeptidase activity
NLK52_17485	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NLK52_17490	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NLK52_17495	COG0556	nucleotide-excision repair
NLK52_17500	COG4897	Protein conserved in bacteria
NLK52_17505	COG0574	Belongs to the PEP-utilizing enzyme family
NLK52_17505	COG3848	Pyruvate phosphate dikinase
NLK52_17510	COG1309	transcriptional regulator
NLK52_17515	COG2814	Major facilitator Superfamily
NLK52_17520	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NLK52_17530	COG3409	Peptidoglycan-binding domain 1 protein
NLK52_17530	COG0793	Belongs to the peptidase S41A family
NLK52_17535	COG2177	Part of the ABC transporter FtsEX involved in
NLK52_17540	COG2884	Cell division ATP-binding protein ftsE
NLK52_17545	COG2010	Cytochrome c
NLK52_17550	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NLK52_17560	COG0653	protein targeting
NLK52_17565	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NLK52_17580	COG1516	flagellar protein fliS
NLK52_17585	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NLK52_17590	COG1334	flagellar protein FlaG
NLK52_17595	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NLK52_17600	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NLK52_17605	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
NLK52_17615	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NLK52_17620	COG4786	Flagellar basal body rod
NLK52_17620	COG1256	bacterial-type flagellum assembly
NLK52_17625	COG3418	PFAM FlgN family protein
NLK52_17630	COG2747	anti-sigma28 factor FlgM
NLK52_17640	COG1040	competence protein
NLK52_17650	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
NLK52_17655	COG1307	EDD domain protein, DegV family
NLK52_17660	COG2197	response regulator
NLK52_17665	COG4585	Histidine kinase
NLK52_17670	COG1739	Uncharacterized protein family UPF0029
NLK52_17675	COG1316	TRANSCRIPTIONal
NLK52_17680	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NLK52_17685	COG0438	transferase activity, transferring glycosyl groups
NLK52_17690	COG1215	transferase activity, transferring glycosyl groups
NLK52_17695	COG3206	protein involved in exopolysaccharide biosynthesis
NLK52_17700	COG3307	-O-antigen
NLK52_17705	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NLK52_17710	COG0297	glycogen (starch) synthase activity
NLK52_17710	COG0438	transferase activity, transferring glycosyl groups
NLK52_17715	COG2244	polysaccharide biosynthetic process
NLK52_17730	COG0860	N-Acetylmuramoyl-L-alanine amidase
NLK52_17730	COG2247	cell wall binding repeat
NLK52_17735	COG2385	sporulation resulting in formation of a cellular spore
NLK52_17735	COG2247	cell wall binding repeat
NLK52_17745	COG1316	TRANSCRIPTIONal
NLK52_17750	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NLK52_17770	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NLK52_17775	COG1134	teichoic acid transport
NLK52_17780	COG1682	transport, permease protein
NLK52_17800	COG0463	Glycosyl transferase, family 2
NLK52_17845	COG4193	domain, Protein
NLK52_17850	COG1482	cell wall glycoprotein biosynthetic process
NLK52_17855	COG0697	spore germination
NLK52_17860	COG0814	amino acid
NLK52_17870	COG2814	Major facilitator Superfamily
NLK52_17875	COG1316	TRANSCRIPTIONal
NLK52_17880	COG0561	phosphatase activity
NLK52_17885	COG0791	NLP P60 protein
NLK52_17895	COG2843	Capsule synthesis protein
NLK52_17905	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NLK52_17910	COG1609	Transcriptional regulator
NLK52_17915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NLK52_17920	COG1869	D-ribose catabolic process
NLK52_17925	COG1129	ABC transporter
NLK52_17930	COG1172	Belongs to the binding-protein-dependent transport system permease family
NLK52_17935	COG1879	ABC-type sugar transport system periplasmic component
NLK52_17940	COG3103	Sh3 type 3 domain protein
NLK52_17950	COG2249	NAD(P)H dehydrogenase (quinone) activity
NLK52_17955	COG3527	Alpha-acetolactate decarboxylase
NLK52_17960	COG0028	Belongs to the TPP enzyme family
NLK52_17965	COG0583	DNA-binding transcription factor activity
NLK52_17970	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NLK52_17985	COG5337	Spore coat protein CotH
NLK52_17995	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NLK52_18005	COG0405	Gamma-glutamyltransferase
NLK52_18010	COG1522	sequence-specific DNA binding
NLK52_18015	COG2059	Chromate
NLK52_18020	COG2059	Chromate
NLK52_18065	COG3878	Protein conserved in bacteria
NLK52_18070	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NLK52_18075	COG4464	protein tyrosine phosphatase activity
NLK52_18080	COG0489	protein tyrosine kinase activity
NLK52_18085	COG3944	biosynthesis protein
NLK52_18095	COG4715	Zinc finger, swim domain protein
NLK52_18100	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NLK52_18105	COG0561	phosphatase activity
NLK52_18110	COG1349	DNA-binding transcription factor activity
NLK52_18115	COG0629	single-stranded DNA binding
NLK52_18130	COG3764	Sortase (surface protein transpeptidase)
NLK52_18140	COG3279	Response regulator of the LytR AlgR family
NLK52_18150	COG0745	RESPONSE REGULATOR receiver
NLK52_18150	COG2972	Histidine kinase
NLK52_18155	COG1970	mechanosensitive ion channel activity
NLK52_18160	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NLK52_18165	COG0457	Tetratricopeptide repeat
NLK52_18170	COG4786	Flagellar basal body rod
NLK52_18175	COG4786	Flagellar basal body rod
NLK52_18180	COG1077	Cell shape determining protein MreB Mrl
NLK52_18185	COG1609	Transcriptional regulator
NLK52_18195	COG1846	Transcriptional regulator
NLK52_18200	COG2814	Major facilitator Superfamily
NLK52_18205	COG3420	alginic acid biosynthetic process
NLK52_18210	COG1953	Uracil, thiamine, allantoin
NLK52_18215	COG0477	Major facilitator Superfamily
NLK52_18220	COG1335	isochorismatase
NLK52_18230	COG0004	ammonium transporteR
NLK52_18235	COG0347	Belongs to the P(II) protein family
NLK52_18240	COG0671	phosphoesterase, PA-phosphatase related
NLK52_18250	COG0739	heme binding
NLK52_18255	COG1247	-acetyltransferase
NLK52_18265	COG2089	acid synthase
NLK52_18275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NLK52_18280	COG0789	Transcriptional regulator
NLK52_18290	COG2910	NAD(P)H-binding
NLK52_18295	COG1959	2 iron, 2 sulfur cluster binding
NLK52_18300	COG0804	urea catabolic process
NLK52_18305	COG0832	Belongs to the urease beta subunit family
NLK52_18310	COG0831	urea catabolic process
NLK52_18325	COG3237	CsbD-like
NLK52_18330	COG1994	Peptidase M50
NLK52_18335	COG0457	Tetratricopeptide repeat
NLK52_18340	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NLK52_18345	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NLK52_18355	COG2304	oxidoreductase activity
NLK52_18365	COG2304	oxidoreductase activity
NLK52_18370	COG2385	sporulation resulting in formation of a cellular spore
NLK52_18375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NLK52_18385	COG4836	Membrane
NLK52_18395	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NLK52_18400	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NLK52_18405	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NLK52_18410	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NLK52_18415	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NLK52_18420	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NLK52_18430	COG0356	it plays a direct role in the translocation of protons across the membrane
NLK52_18440	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NLK52_18445	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NLK52_18450	COG4475	Protein of unknown function (DUF436)
NLK52_18455	COG0698	ribose 5-phosphate isomerase
NLK52_18460	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NLK52_18465	COG1971	Probably functions as a manganese efflux pump
NLK52_18470	COG0009	L-threonylcarbamoyladenylate synthase
NLK52_18475	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NLK52_18495	COG2890	protein-(glutamine-N5) methyltransferase activity
NLK52_18500	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NLK52_18505	COG0346	lactoylglutathione lyase activity
NLK52_18510	COG0789	Transcriptional regulator
NLK52_18515	COG0679	Auxin Efflux Carrier
NLK52_18520	COG0281	malic enzyme
NLK52_18525	COG1435	thymidine kinase activity
NLK52_18535	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NLK52_18545	COG1494	fructose-1,6-bisphosphatase
NLK52_18550	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NLK52_18555	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NLK52_18560	COG0191	fructose-bisphosphate aldolase activity
NLK52_18565	COG2204	response regulator
NLK52_18570	COG4821	SIS domain
NLK52_18575	COG0504	CTP synthase activity
NLK52_18580	COG3343	RNA polymerase activity
NLK52_18585	COG1960	acyl-CoA dehydrogenase activity
NLK52_18590	COG0247	lactate metabolic process
NLK52_18590	COG2181	nitrate reductase activity
NLK52_18595	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NLK52_18600	COG4294	response to UV
NLK52_18610	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NLK52_18615	COG1132	(ABC) transporter
NLK52_18620	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NLK52_18630	COG2181	nitrate reductase activity
NLK52_18635	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
NLK52_18640	COG1140	nitrate reductase beta subunit
NLK52_18645	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
NLK52_18650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NLK52_18660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NLK52_18665	COG2223	nitrite transmembrane transporter activity
NLK52_18670	COG0018	arginyl-trna synthetase
NLK52_18675	COG4506	Protein conserved in bacteria
NLK52_18690	COG0535	radical SAM domain protein
NLK52_18700	COG1131	(ABC) transporter
NLK52_18705	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NLK52_18710	COG0612	Peptidase, M16
NLK52_18715	COG0612	Peptidase, M16
NLK52_18725	COG3391	amine dehydrogenase activity
NLK52_18730	COG3391	amine dehydrogenase activity
NLK52_18735	COG0457	Tetratricopeptide repeat
NLK52_18755	COG1131	(ABC) transporter
NLK52_18765	COG0010	Belongs to the arginase family
NLK52_18770	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NLK52_18775	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NLK52_18785	COG1994	Peptidase M50
NLK52_18790	COG1942	4-Oxalocrotonate Tautomerase
NLK52_18795	COG1846	Transcriptional regulator
NLK52_18800	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NLK52_18810	COG0477	Major facilitator Superfamily
NLK52_18815	COG1959	2 iron, 2 sulfur cluster binding
NLK52_18820	COG3465	dGTPase activity
NLK52_18825	COG1078	dGTPase activity
NLK52_18830	COG4844	belongs to the
NLK52_18840	COG0697	spore germination
NLK52_18845	COG0095	Lipoate-protein ligase
NLK52_18850	COG0583	DNA-binding transcription factor activity
NLK52_18855	COG0280	phosphate acetyltransferase
NLK52_18860	COG3253	May function as heme-dependent peroxidase
NLK52_18865	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_18870	COG0436	Aminotransferase
NLK52_18875	COG2814	Major facilitator Superfamily
NLK52_18880	COG0151	Belongs to the GarS family
NLK52_18885	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_18890	COG1917	Cupin 2, conserved barrel domain protein
NLK52_18895	COG0077	Prephenate dehydratase
NLK52_18900	COG2814	Major facilitator Superfamily
NLK52_18905	COG0833	amino acid
NLK52_18910	COG4187	Peptidase family M20/M25/M40
NLK52_18915	COG1012	belongs to the aldehyde dehydrogenase family
NLK52_18920	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NLK52_18930	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
NLK52_18935	COG1091	dTDP-4-dehydrorhamnose reductase activity
NLK52_18940	COG1088	dTDP-glucose 4,6-dehydratase activity
NLK52_18945	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NLK52_18950	COG3980	spore coat polysaccharide biosynthesis protein
NLK52_18955	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
NLK52_18960	COG2089	acid synthase
NLK52_18965	COG0456	acetyltransferase
NLK52_18970	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NLK52_18975	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NLK52_18980	COG0463	Glycosyl transferase, family 2
NLK52_18990	COG2363	Small membrane protein
NLK52_18995	COG2233	PERMEase
NLK52_19005	COG1012	belongs to the aldehyde dehydrogenase family
NLK52_19010	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NLK52_19015	COG1216	Glycosyl transferase, family 2
NLK52_19020	COG0351	phosphomethylpyrimidine kinase
NLK52_19030	COG1621	beta-fructofuranosidase activity
NLK52_19035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NLK52_19035	COG1263	PTS System
NLK52_19045	COG3711	transcriptional antiterminator
NLK52_19055	COG1404	Belongs to the peptidase S8 family
NLK52_19060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NLK52_19065	COG0778	Nitroreductase
NLK52_19070	COG0772	Belongs to the SEDS family
NLK52_19080	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NLK52_19085	COG1845	cytochrome c oxidase, subunit III
NLK52_19090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NLK52_19095	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NLK52_19100	COG2261	transglycosylase associated protein
NLK52_19105	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
NLK52_19110	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NLK52_19115	COG2246	polysaccharide biosynthetic process
NLK52_19120	COG1309	transcriptional regulator
NLK52_19130	COG3162	membrane
NLK52_19135	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NLK52_19140	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NLK52_19145	COG2837	iron assimilation
NLK52_19150	COG2822	iron ion transport
NLK52_19155	COG0672	)-iron permease
NLK52_19160	COG0352	thiamine-phosphate diphosphorylase activity
NLK52_19165	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
NLK52_19170	COG0583	DNA-binding transcription factor activity
NLK52_19175	COG1380	Effector of murein hydrolase LrgA
NLK52_19180	COG1346	cytolysis
NLK52_19185	COG2814	Major facilitator Superfamily
NLK52_19190	COG4895	conserved protein (DUF2196)
NLK52_19195	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NLK52_19200	COG0346	lactoylglutathione lyase activity
NLK52_19210	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NLK52_19215	COG1404	Belongs to the peptidase S8 family
NLK52_19220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NLK52_19220	COG1263	PTS System
NLK52_19225	COG3711	transcriptional antiterminator
NLK52_19230	COG1442	glycosyl transferase family 8
NLK52_19235	COG5522	Integral membrane protein (intg_mem_TP0381)
NLK52_19240	COG1846	Transcriptional regulator
NLK52_19245	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NLK52_19250	COG2234	aminopeptidase activity
NLK52_19255	COG2357	RelA SpoT domain protein
NLK52_19260	COG1575	Belongs to the MenA family. Type 1 subfamily
NLK52_19275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NLK52_19280	COG1696	Membrane protein involved in D-alanine export
NLK52_19285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NLK52_19290	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
NLK52_19295	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
NLK52_19300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NLK52_19305	COG1486	melibiose metabolic process
NLK52_19310	COG1447	Phosphotransferase system cellobiose-specific component IIA
NLK52_19315	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NLK52_19320	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NLK52_19325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NLK52_19325	COG3711	transcriptional antiterminator
NLK52_19335	COG2094	Belongs to the DNA glycosylase MPG family
NLK52_19340	COG0753	catalase activity
NLK52_19345	COG2814	Major facilitator Superfamily
NLK52_19350	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NLK52_19355	COG1131	(ABC) transporter
NLK52_19375	COG1595	DNA-templated transcription, initiation
NLK52_19380	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NLK52_19385	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NLK52_19390	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NLK52_19395	COG4988	ABC transporter
NLK52_19400	COG1294	oxidase, subunit
NLK52_19405	COG1271	oxidase subunit
NLK52_19410	COG3493	citrate carrier protein
NLK52_19415	COG0501	Belongs to the peptidase M48B family
NLK52_19425	COG0726	polysaccharide deacetylase
NLK52_19430	COG3842	ATPase activity
NLK52_19435	COG2508	Transcriptional regulator
NLK52_19440	COG1012	belongs to the aldehyde dehydrogenase family
NLK52_19445	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NLK52_19455	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NLK52_19460	COG1881	PFAM PEBP family protein
NLK52_19465	COG0583	DNA-binding transcription factor activity
NLK52_19475	COG4585	Histidine kinase
NLK52_19480	COG2197	response regulator
NLK52_19485	COG2195	Cleaves the N-terminal amino acid of tripeptides
NLK52_19495	COG4894	glucomannan catabolic process
NLK52_19500	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NLK52_19505	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NLK52_19510	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_19515	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NLK52_19520	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NLK52_19525	COG2610	gluconate transmembrane transporter activity
NLK52_19530	COG0500	methyltransferase
NLK52_19535	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NLK52_19550	COG0693	protein deglycase activity
NLK52_19550	COG0753	catalase activity
NLK52_19555	COG2851	Citrate transporter
NLK52_19560	COG2273	Hydrolase Family 16
NLK52_19565	COG3711	transcriptional antiterminator
NLK52_19575	COG2270	Major facilitator Superfamily
NLK52_19580	COG0513	Belongs to the DEAD box helicase family
NLK52_19585	COG3401	FG-GAP repeat protein
NLK52_19585	COG2755	lipolytic protein G-D-S-L family
NLK52_19605	COG0697	spore germination
NLK52_19610	COG0589	response to stress
NLK52_19615	COG2723	6-phospho-beta-galactosidase activity
NLK52_19620	COG1263	PTS System
NLK52_19620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NLK52_19620	COG2190	(PTS) system
NLK52_19670	COG5444	nuclease activity
NLK52_19695	COG0494	nUDIX hydrolase
NLK52_19700	COG3507	Belongs to the glycosyl hydrolase 43 family
NLK52_19715	COG2986	histidine ammonia-lyase
NLK52_19720	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NLK52_19725	COG1228	amidohydrolase
NLK52_19730	COG0010	Belongs to the arginase family
NLK52_19735	COG0833	amino acid
NLK52_19740	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NLK52_19745	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NLK52_19750	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NLK52_19755	COG2390	Transcriptional regulator
NLK52_19765	COG3192	ethanolamine utilization protein
NLK52_19770	COG2079	MmgE PrpD family protein
NLK52_19775	COG1473	amidohydrolase
NLK52_19780	COG1126	abc transporter atp-binding protein
NLK52_19785	COG0765	amino acid transport
NLK52_19790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NLK52_19795	COG0456	acetyltransferase
NLK52_19800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NLK52_19805	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
NLK52_19810	COG0561	phosphatase activity
NLK52_19840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NLK52_19845	COG5294	Protein conserved in bacteria
NLK52_19850	COG0577	efflux transmembrane transporter activity
NLK52_19855	COG1136	(ABC) transporter
NLK52_19860	COG2205	protein histidine kinase activity
NLK52_19865	COG0745	RESPONSE REGULATOR receiver
NLK52_19870	COG0191	fructose-bisphosphate aldolase activity
NLK52_19875	COG1082	Xylose isomerase domain protein TIM barrel
NLK52_19880	COG1082	Xylose isomerase domain protein TIM barrel
NLK52_19885	COG0673	inositol 2-dehydrogenase activity
NLK52_19890	COG2814	Major facilitator Superfamily
NLK52_19895	COG1082	Xylose isomerase domain protein TIM barrel
NLK52_19900	COG3962	Belongs to the TPP enzyme family
NLK52_19905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NLK52_19915	COG1012	belongs to the aldehyde dehydrogenase family
NLK52_19920	COG1349	DNA-binding transcription factor activity
NLK52_19925	COG0667	Aldo Keto reductase
NLK52_19940	COG2814	Major facilitator Superfamily
NLK52_19945	COG0326	Molecular chaperone. Has ATPase activity
NLK52_19955	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_19960	COG1309	transcriptional regulator
NLK52_19965	COG1012	belongs to the aldehyde dehydrogenase family
NLK52_19970	COG1714	RDD family
NLK52_19975	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NLK52_19985	COG1714	RDD family
NLK52_19990	COG2311	Membrane
NLK52_19995	COG1917	Cupin 2, conserved barrel domain protein
NLK52_20000	COG1309	transcriptional regulator
NLK52_20005	COG1028	Short-chain dehydrogenase reductase Sdr
NLK52_20010	COG1846	Transcriptional regulator
NLK52_20015	COG1380	Effector of murein hydrolase LrgA
NLK52_20020	COG1346	cytolysis
NLK52_20025	COG5039	Polysaccharide pyruvyl transferase
NLK52_20030	COG1929	Belongs to the glycerate kinase type-1 family
NLK52_20035	COG1802	Transcriptional regulator
NLK52_20040	COG1070	Carbohydrate kinase
NLK52_20045	COG2610	gluconate transmembrane transporter activity
NLK52_20050	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NLK52_20055	COG0450	alkyl hydroperoxide reductase
NLK52_20060	COG3634	alkyl hydroperoxide reductase activity
NLK52_20070	COG2723	6-phospho-beta-galactosidase activity
NLK52_20075	COG2190	(PTS) system
NLK52_20080	COG2188	Transcriptional regulator
NLK52_20095	COG1131	(ABC) transporter
NLK52_20100	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
NLK52_20110	COG2189	Belongs to the N(4) N(6)-methyltransferase family
NLK52_20125	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NLK52_20140	COG1063	alcohol dehydrogenase
NLK52_20160	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
NLK52_20165	COG0456	acetyltransferase
NLK52_20170	COG0457	Tetratricopeptide repeat
NLK52_20180	COG0010	Belongs to the arginase family
NLK52_20185	COG0833	amino acid
NLK52_20190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NLK52_20195	COG3829	transcription factor binding
NLK52_20210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NLK52_20215	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NLK52_20220	COG4853	Protein conserved in bacteria
NLK52_20225	COG4863	YycH protein
NLK52_20230	COG5002	protein histidine kinase activity
NLK52_20235	COG0745	RESPONSE REGULATOR receiver
NLK52_20265	COG0346	lactoylglutathione lyase activity
NLK52_20270	COG0305	Participates in initiation and elongation during chromosome replication
NLK52_20285	COG3093	addiction module antidote protein HigA
NLK52_20290	COG2807	transmembrane transport
NLK52_20295	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NLK52_20300	COG0359	binds to the 23S rRNA
NLK52_20305	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
NLK52_20310	COG4241	membrane
NLK52_20320	COG5577	PFAM Coat F domain
NLK52_20325	COG1733	regulation of RNA biosynthetic process
NLK52_20330	COG1227	inorganic diphosphatase activity
NLK52_20340	COG2271	Major facilitator Superfamily
NLK52_20345	COG4978	Transcriptional regulator
NLK52_20345	COG0789	Transcriptional regulator
NLK52_20355	COG4319	ketosteroid isomerase
NLK52_20360	COG1357	PFAM Pentapeptide repeats (8 copies)
NLK52_20365	COG2814	Major facilitator Superfamily
NLK52_20370	COG0583	DNA-binding transcription factor activity
NLK52_20375	COG2153	protein acetylation
NLK52_20385	COG0583	DNA-binding transcription factor activity
NLK52_20400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NLK52_20405	COG1846	Transcriptional regulator
NLK52_20410	COG2153	protein acetylation
NLK52_20415	COG2364	Membrane
NLK52_20420	COG0456	acetyltransferase
NLK52_20425	COG2315	Protein conserved in bacteria
NLK52_20430	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NLK52_20440	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NLK52_20445	COG0798	PFAM Bile acid sodium symporter
NLK52_20450	COG0346	lactoylglutathione lyase activity
NLK52_20455	COG0640	Transcriptional regulator
NLK52_20465	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NLK52_20475	COG0863	Belongs to the N(4) N(6)-methyltransferase family
NLK52_20485	COG1331	Highly conserved protein containing a thioredoxin domain
NLK52_20490	COG1266	CAAX protease self-immunity
NLK52_20495	COG0477	Major facilitator Superfamily
NLK52_20495	COG2814	Major facilitator Superfamily
NLK52_20500	COG0110	maltose O-acetyltransferase activity
NLK52_20505	COG0346	lactoylglutathione lyase activity
NLK52_20510	COG1609	Transcriptional regulator
NLK52_20515	COG0708	Exodeoxyribonuclease III
NLK52_20520	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NLK52_20525	COG0629	single-stranded DNA binding
NLK52_20530	COG0360	Binds together with S18 to 16S ribosomal RNA
NLK52_20535	COG0012	GTP binding
NLK52_20540	COG0243	molybdopterin cofactor binding
NLK52_20545	COG4481	Protein conserved in bacteria
NLK52_20550	COG3949	Membrane
NLK52_20560	COG1475	DNA binding
NLK52_20565	COG1192	Involved in chromosome partitioning
NLK52_20575	COG1475	DNA binding
NLK52_20580	COG0357	Ribosomal RNA small subunit methyltransferase G
NLK52_20585	COG0445	tRNA wobble uridine modification
NLK52_20590	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NLK52_20595	COG1847	R3H domain protein
NLK52_20600	COG0706	membrane insertase activity
NLK52_20605	COG0594	ribonuclease P activity