locus-tag	class	description
MX663_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
MX663_00010	COG0592	DNA-directed DNA polymerase activity
MX663_00015	COG2501	S4 domain
MX663_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
MX663_00030	COG0187	DNA topoisomerase II activity
MX663_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MX663_00070	COG0516	GMP reductase activity
MX663_00070	COG0517	IMP dehydrogenase activity
MX663_00075	COG1686	Belongs to the peptidase S11 family
MX663_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
MX663_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
MX663_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
MX663_00100	COG1428	Deoxynucleoside kinase
MX663_00105	COG1428	Deoxynucleoside kinase
MX663_00110	COG1388	LysM domain
MX663_00110	COG3858	chitin binding
MX663_00115	COG1335	isochorismatase
MX663_00120	COG0590	tRNA wobble adenosine to inosine editing
MX663_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
MX663_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
MX663_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
MX663_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
MX663_00190	COG3853	Toxic anion resistance protein (TelA)
MX663_00195	COG1982	Orn Lys Arg decarboxylase major
MX663_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MX663_00205	COG3870	Protein conserved in bacteria
MX663_00210	COG1728	Protein conserved in bacteria
MX663_00215	COG0470	DNA polymerase III
MX663_00220	COG1774	PSP1 C-terminal conserved region
MX663_00225	COG4467	Involved in initiation control of chromosome replication
MX663_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
MX663_00235	COG2827	Endonuclease containing a URI domain
MX663_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
MX663_00245	COG2002	toxin-antitoxin pair type II binding
MX663_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MX663_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MX663_00255	COG0084	hydrolase, TatD family'
MX663_00260	COG3583	domain protein
MX663_00260	COG3584	3D domain protein
MX663_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MX663_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
MX663_00280	COG4466	Protein conserved in bacteria
MX663_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
MX663_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MX663_00300	COG0251	oxidation-reduction process
MX663_00305	COG2088	sporulation resulting in formation of a cellular spore
MX663_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
MX663_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
MX663_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
MX663_00325	COG0193	aminoacyl-tRNA hydrolase activity
MX663_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
MX663_00340	COG2002	toxin-antitoxin pair type II binding
MX663_00345	COG2244	polysaccharide biosynthetic process
MX663_00350	COG3956	TIGRFAM MazG family protein
MX663_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
MX663_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
MX663_00375	COG1098	S1 RNA binding domain
MX663_00390	COG2208	phosphoserine phosphatase activity
MX663_00395	COG2304	oxidoreductase activity
MX663_00400	COG0515	serine threonine protein kinase
MX663_00405	COG0037	tRNA processing
MX663_00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
MX663_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MX663_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
MX663_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
MX663_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MX663_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MX663_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MX663_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
MX663_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MX663_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
MX663_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
MX663_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
MX663_00470	COG1396	sequence-specific DNA binding
MX663_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MX663_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
MX663_00560	COG4463	regulation of RNA biosynthetic process
MX663_00565	COG3880	PFAM UvrB UvrC protein
MX663_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
MX663_00575	COG0542	response to heat
MX663_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
MX663_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
MX663_00590	COG4956	integral membrane protein (PIN domain superfamily)
MX663_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
MX663_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
MX663_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
MX663_00610	COG1045	serine acetyltransferase
MX663_00615	COG0215	cysteine-tRNA ligase activity
MX663_00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
MX663_00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MX663_00630	COG3688	RNA-binding protein containing a PIN domain
MX663_00635	COG1595	DNA-templated transcription, initiation
MX663_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MX663_00650	COG0250	Participates in transcription elongation, termination and antitermination
MX663_00660	COG0081	regulation of translation
MX663_00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
MX663_00675	COG2813	Specifically methylates the guanine in position
MX663_00680	COG0085	RNA polymerase activity
MX663_00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
MX663_00690	COG1358	cellular component organization or biogenesis
MX663_00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
MX663_00700	COG0049	tRNA binding
MX663_00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
MX663_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
MX663_00715	COG0596	Alpha beta hydrolase
MX663_00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
MX663_00730	COG0088	Forms part of the polypeptide exit tunnel
MX663_00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
MX663_00755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
MX663_00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
MX663_00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
MX663_00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
MX663_00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
MX663_00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
MX663_00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
MX663_00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
MX663_00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
MX663_00820	COG0200	Binds to the 23S rRNA
MX663_00825	COG0201	protein transport
MX663_00830	COG0563	adenylate kinase activity
MX663_00835	COG0024	Methionine aminopeptidase
MX663_00840	COG2163	COG2163 Ribosomal protein L14E L6E L27E
MX663_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
MX663_00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
MX663_00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
MX663_00865	COG0202	RNA polymerase activity
MX663_00870	COG0203	ribosomal protein L17
MX663_00875	COG1122	ATPase activity
MX663_00880	COG1122	ATPase activity
MX663_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MX663_00890	COG0101	tRNA pseudouridine synthase activity
MX663_00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
MX663_00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
MX663_00905	COG2226	methyltransferase
MX663_00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
MX663_00920	COG0489	protein tyrosine kinase activity
MX663_00930	COG2194	sulfuric ester hydrolase activity
MX663_00935	COG0726	polysaccharide deacetylase
MX663_00985	COG1395	domain, Protein
MX663_01075	COG5444	nuclease activity
MX663_01140	COG0659	secondary active sulfate transmembrane transporter activity
MX663_01145	COG0385	Bile acid
MX663_01150	COG2819	hydrolase of the alpha beta superfamily
MX663_01155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MX663_01160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MX663_01165	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MX663_01170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MX663_01170	COG2207	Transcriptional regulator
MX663_01175	COG3876	Protein conserved in bacteria
MX663_01180	COG1472	Belongs to the glycosyl hydrolase 3 family
MX663_01185	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MX663_01190	COG1263	PTS System
MX663_01190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MX663_01195	COG1737	Transcriptional regulator
MX663_01200	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
MX663_01205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MX663_01210	COG1683	Conserved Protein
MX663_01240	COG1595	DNA-templated transcription, initiation
MX663_01245	COG5662	AntiSigma factor
MX663_01250	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MX663_01255	COG4856	YbbR-like protein
MX663_01260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MX663_01265	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
MX663_01275	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MX663_01280	COG2169	Transcriptional regulator
MX663_01285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MX663_01290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MX663_01295	COG3002	Belongs to the UPF0753 family
MX663_01300	COG0288	reversible hydration of carbon dioxide
MX663_01310	COG5609	conserved protein (DUF2294)
MX663_01315	COG0640	Transcriptional regulator
MX663_01320	COG2814	Major facilitator Superfamily
MX663_01335	COG1404	Belongs to the peptidase S8 family
MX663_01355	COG1132	(ABC) transporter
MX663_01360	COG0596	Alpha beta hydrolase
MX663_01365	COG0745	RESPONSE REGULATOR receiver
MX663_01370	COG0642	Histidine kinase
MX663_01380	COG0515	serine threonine protein kinase
MX663_01395	COG1113	amino acid transport
MX663_01410	COG2602	Beta-lactamase
MX663_01415	COG2124	cytochrome p450
MX663_01425	COG0531	amino acid
MX663_01430	COG0584	glycerophosphoryl diester phosphodiesterase
MX663_01435	COG2271	Major facilitator Superfamily
MX663_01445	COG1846	Transcriptional regulator
MX663_01445	COG0456	acetyltransferase
MX663_01450	COG2271	Major facilitator Superfamily
MX663_01460	COG3409	Peptidoglycan-binding domain 1 protein
MX663_01465	COG0697	spore germination
MX663_01470	COG1917	Cupin 2, conserved barrel domain protein
MX663_01470	COG2207	Transcriptional regulator
MX663_01475	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
MX663_01480	COG3591	Belongs to the peptidase S1B family
MX663_01490	COG0596	Alpha beta hydrolase
MX663_01495	COG1183	phosphatidylcholine synthase activity
MX663_01500	COG0586	Pfam SNARE associated Golgi protein
MX663_01505	COG0688	phosphatidylethanolamine metabolic process
MX663_01520	COG1054	Belongs to the UPF0176 family
MX663_01525	COG1301	dicarboxylic acid transport
MX663_01530	COG2190	(PTS) system
MX663_01530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MX663_01530	COG1263	PTS System
MX663_01535	COG0363	glucosamine-6-phosphate deaminase activity
MX663_01540	COG2188	Transcriptional regulator
MX663_01550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MX663_01555	COG0833	amino acid
MX663_01560	COG2040	homocysteine
MX663_01565	COG1115	amino acid carrier protein
MX663_01570	COG2066	Belongs to the glutaminase family
MX663_01575	COG4191	Histidine kinase
MX663_01580	COG0784	Response regulator, receiver
MX663_01585	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MX663_01590	COG1012	belongs to the aldehyde dehydrogenase family
MX663_01595	COG2271	Major facilitator Superfamily
MX663_01600	COG4948	Mandelate Racemase Muconate Lactonizing
MX663_01605	COG2186	Transcriptional regulator
MX663_01610	COG2721	sulfolactate sulfo-lyase activity
MX663_01615	COG3173	Aminoglycoside phosphotransferase
MX663_01625	COG0697	spore germination
MX663_01630	COG0745	RESPONSE REGULATOR receiver
MX663_01635	COG2205	protein histidine kinase activity
MX663_01640	COG1131	(ABC) transporter
MX663_01660	COG3773	Cell wall hydrolase
MX663_01665	COG2304	oxidoreductase activity
MX663_01675	COG3540	Alkaline phosphatase
MX663_01680	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MX663_01685	COG0805	protein transport
MX663_01690	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
MX663_01695	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MX663_01700	COG0477	Major facilitator Superfamily
MX663_01705	COG1309	transcriptional regulator
MX663_01710	COG0252	asparaginase activity
MX663_01715	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MX663_01720	COG1714	RDD family
MX663_01725	COG3012	SEC-C Motif Domain Protein
MX663_01725	COG1405	negative regulation of cell septum assembly
MX663_01730	COG3290	protein histidine kinase activity
MX663_01735	COG3279	Response regulator of the LytR AlgR family
MX663_01740	COG4555	ABC transporter
MX663_01745	COG1668	transmembrane transport
MX663_01750	COG0667	Aldo Keto reductase
MX663_01765	COG1595	DNA-templated transcription, initiation
MX663_01770	COG1595	DNA-templated transcription, initiation
MX663_01775	COG1876	peptidase activity
MX663_01780	COG0457	Tetratricopeptide repeat
MX663_01785	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_01790	COG0366	Alpha amylase catalytic
MX663_01795	COG0803	Belongs to the bacterial solute-binding protein 9 family
MX663_01800	COG1121	(ABC) transporter
MX663_01805	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MX663_01810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MX663_01815	COG2310	stress, protein
MX663_01820	COG2310	stress, protein
MX663_01825	COG2310	stress, protein
MX663_01830	COG0861	Integral membrane protein TerC family
MX663_01840	COG3853	Toxic anion resistance protein (TelA)
MX663_01845	COG0477	Major facilitator Superfamily
MX663_01850	COG2814	Major facilitator Superfamily
MX663_01855	COG0640	Transcriptional regulator
MX663_01860	COG4175	Glycine betaine
MX663_01860	COG0517	IMP dehydrogenase activity
MX663_01865	COG4176	ABC-type proline glycine betaine transport system permease component
MX663_01870	COG2113	Glycine betaine
MX663_01875	COG1473	amidohydrolase
MX663_01880	COG1288	antiporter activity
MX663_01890	COG0366	Alpha amylase catalytic
MX663_01895	COG0039	L-malate dehydrogenase activity
MX663_01900	COG1620	l-lactate permease
MX663_01905	COG2814	Major facilitator Superfamily
MX663_01910	COG1846	Transcriptional regulator
MX663_01915	COG1280	lysine exporter protein (LysE YggA)
MX663_01920	COG3403	YqcI/YcgG family
MX663_01925	COG1113	amino acid transport
MX663_01930	COG3665	Urea carboxylase-associated protein
MX663_01935	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
MX663_01940	COG1660	Displays ATPase and GTPase activities
MX663_01945	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
MX663_01950	COG2226	methyltransferase
MX663_01955	COG0583	DNA-binding transcription factor activity
MX663_01960	COG3458	cephalosporin-C deacetylase activity
MX663_01965	COG3541	Predicted nucleotidyltransferase
MX663_01970	COG0506	proline dehydrogenase activity
MX663_01975	COG1012	belongs to the aldehyde dehydrogenase family
MX663_01980	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MX663_01985	COG2508	Transcriptional regulator
MX663_01990	COG3689	TIGRFAM TIGR03943 family protein
MX663_01995	COG0701	Predicted permease
MX663_02000	COG2267	carboxylic ester hydrolase activity
MX663_02005	COG0492	ferredoxin-NADP+ reductase activity
MX663_02010	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MX663_02010	COG1587	Uroporphyrinogen-III synthase
MX663_02015	COG2146	nitrite reductase [NAD(P)H] activity
MX663_02020	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MX663_02025	COG0243	molybdopterin cofactor binding
MX663_02030	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MX663_02035	COG2223	nitrite transmembrane transporter activity
MX663_02040	COG1469	GTP cyclohydrolase I activity
MX663_02045	COG1376	ErfK ybiS ycfS ynhG family protein
MX663_02055	COG0523	cobalamin synthesis protein
MX663_02060	COG0765	amino acid transport
MX663_02065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MX663_02085	COG2723	6-phospho-beta-galactosidase activity
MX663_02095	COG3209	COG3209 Rhs family protein
MX663_02100	COG0840	transmembrane signaling receptor activity
MX663_02100	COG3290	protein histidine kinase activity
MX663_02105	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
MX663_02110	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
MX663_02115	COG1733	regulation of RNA biosynthetic process
MX663_02120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MX663_02140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MX663_02145	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MX663_02150	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
MX663_02155	COG2814	Major facilitator Superfamily
MX663_02165	COG0697	spore germination
MX663_02170	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MX663_02180	COG2364	Membrane
MX663_02185	COG1126	abc transporter atp-binding protein
MX663_02190	COG0765	amino acid transport
MX663_02195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MX663_02200	COG0583	DNA-binding transcription factor activity
MX663_02205	COG0163	prenyltransferase activity
MX663_02210	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
MX663_02225	COG0596	Alpha beta hydrolase
MX663_02230	COG3104	oligopeptide transport
MX663_02235	COG5434	Belongs to the glycosyl hydrolase 28 family
MX663_02245	COG0697	spore germination
MX663_02255	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
MX663_02260	COG1136	(ABC) transporter
MX663_02265	COG0577	efflux transmembrane transporter activity
MX663_02270	COG0745	RESPONSE REGULATOR receiver
MX663_02275	COG3850	Histidine kinase
MX663_02275	COG5002	protein histidine kinase activity
MX663_02280	COG0457	Tetratricopeptide repeat
MX663_02300	COG0527	aspartate kinase activity
MX663_02305	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MX663_02310	COG4605	iron ion homeostasis
MX663_02315	COG4604	ABC transporter, ATP-binding protein
MX663_02320	COG4607	ABC-type enterochelin transport system periplasmic component
MX663_02325	COG2814	Major facilitator Superfamily
MX663_02330	COG1309	transcriptional regulator
MX663_02335	COG0778	Nitroreductase
MX663_02340	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
MX663_02345	COG0640	Transcriptional regulator
MX663_02350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MX663_02355	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
MX663_02360	COG1012	belongs to the aldehyde dehydrogenase family
MX663_02365	COG4975	Glucose uptake
MX663_02370	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_02375	COG4549	nuclear export factor GLE1
MX663_02380	COG1276	copper resistance
MX663_02380	COG2372	response to copper ion
MX663_02385	COG1349	DNA-binding transcription factor activity
MX663_02395	COG2213	PTS system mannitol-specific
MX663_02400	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
MX663_02405	COG0246	Mannitol dehydrogenase
MX663_02410	COG0473	3-isopropylmalate dehydrogenase activity
MX663_02415	COG0681	Belongs to the peptidase S26 family
MX663_02420	COG0412	Dienelactone hydrolase
MX663_02425	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MX663_02435	COG0561	phosphatase activity
MX663_02440	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
MX663_02445	COG1914	H( )-stimulated, divalent metal cation uptake system
MX663_02450	COG4336	lyase activity
MX663_02455	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
MX663_02460	COG1984	allophanate hydrolase subunit 2
MX663_02465	COG1414	Transcriptional regulator
MX663_02470	COG2755	lipolytic protein G-D-S-L family
MX663_02480	COG2329	Antibiotic biosynthesis monooxygenase
MX663_02485	COG0768	penicillin binding
MX663_02490	COG4989	oxidoreductase activity
MX663_02495	COG3711	transcriptional antiterminator
MX663_02500	COG0318	PFAM AMP-dependent synthetase and ligase
MX663_02505	COG2226	methyltransferase
MX663_02510	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_02515	COG1917	Cupin 2, conserved barrel domain protein
MX663_02520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MX663_02525	COG3871	stress protein (general stress protein 26)
MX663_02535	COG2814	Major facilitator Superfamily
MX663_02540	COG1522	sequence-specific DNA binding
MX663_02545	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MX663_02545	COG0551	DNA topoisomerase type I activity
MX663_02550	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
MX663_02555	COG3706	GGDEF domain
MX663_02560	COG5298	Protein conserved in bacteria
MX663_02565	COG1215	transferase activity, transferring glycosyl groups
MX663_02575	COG0531	amino acid
MX663_02585	COG0028	Belongs to the TPP enzyme family
MX663_02600	COG1914	H( )-stimulated, divalent metal cation uptake system
MX663_02605	COG2261	transglycosylase associated protein
MX663_02610	COG4876	unkown
MX663_02615	COG2217	Heavy metal translocating P-type atpase
MX663_02620	COG3729	General stress protein
MX663_02625	COG0662	Cupin 2, conserved barrel domain protein
MX663_02630	COG2329	Antibiotic biosynthesis monooxygenase
MX663_02635	COG3546	catalase activity
MX663_02640	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
MX663_02645	COG3290	protein histidine kinase activity
MX663_02650	COG4565	transcriptional regulatory protein
MX663_02655	COG1301	dicarboxylic acid transport
MX663_02660	COG0628	permease
MX663_02670	COG1131	(ABC) transporter
MX663_02675	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MX663_02685	COG1960	acyl-CoA dehydrogenase activity
MX663_02700	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MX663_02705	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MX663_02710	COG1181	Belongs to the D-alanine--D-alanine ligase family
MX663_02715	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
MX663_02720	COG0513	Belongs to the DEAD box helicase family
MX663_02725	COG3402	PFAM membrane-flanked domain
MX663_02730	COG3428	Bacterial PH domain
MX663_02735	COG0705	Rhomboid family
MX663_02740	COG0736	holo-[acyl-carrier-protein] synthase activity
MX663_02745	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
MX663_02750	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MX663_02755	COG0864	Transcriptional regulator
MX663_02760	COG2337	Toxic component of a toxin-antitoxin (TA) module
MX663_02765	COG1366	Belongs to the anti-sigma-factor antagonist family
MX663_02770	COG1366	Belongs to the anti-sigma-factor antagonist family
MX663_02775	COG2172	sigma factor antagonist activity
MX663_02780	COG2208	phosphoserine phosphatase activity
MX663_02785	COG1366	Belongs to the anti-sigma-factor antagonist family
MX663_02790	COG2172	sigma factor antagonist activity
MX663_02795	COG1191	sigma factor activity
MX663_02800	COG2208	phosphoserine phosphatase activity
MX663_02805	COG2183	response to ionizing radiation
MX663_02815	COG3091	SprT-like family
MX663_02855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MX663_02865	COG5444	nuclease activity
MX663_02870	COG1476	TRANSCRIPTIONal
MX663_02880	COG3239	Fatty acid desaturase
MX663_02885	COG1278	Cold shock
MX663_02890	COG1329	Transcriptional regulator
MX663_02900	COG0697	spore germination
MX663_02905	COG2207	Transcriptional regulator
MX663_02905	COG1917	Cupin 2, conserved barrel domain protein
MX663_02910	COG0697	spore germination
MX663_02915	COG3708	Transcriptional regulator
MX663_02915	COG2207	Transcriptional regulator
MX663_02920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MX663_02925	COG0477	Major facilitator Superfamily
MX663_02935	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
MX663_02945	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MX663_02950	COG1309	transcriptional regulator
MX663_02955	COG0697	spore germination
MX663_02960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MX663_02965	COG2030	dehydratase
MX663_02970	COG3545	Serine hydrolase
MX663_02975	COG1733	regulation of RNA biosynthetic process
MX663_02980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MX663_02985	COG1733	regulation of RNA biosynthetic process
MX663_02990	COG2249	NAD(P)H dehydrogenase (quinone) activity
MX663_02995	COG2814	Major facilitator Superfamily
MX663_03000	COG1309	transcriptional regulator
MX663_03005	COG0640	Transcriptional regulator
MX663_03010	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MX663_03020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MX663_03025	COG0697	spore germination
MX663_03030	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MX663_03035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MX663_03040	COG0640	Transcriptional regulator
MX663_03045	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MX663_03060	COG4585	Histidine kinase
MX663_03065	COG2197	response regulator
MX663_03070	COG2409	Drug exporters of the RND superfamily
MX663_03075	COG0596	Alpha beta hydrolase
MX663_03080	COG1811	Na channel or pump
MX663_03085	COG4978	Transcriptional regulator
MX663_03085	COG0789	Transcriptional regulator
MX663_03090	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MX663_03095	COG0778	Nitroreductase
MX663_03100	COG0346	lactoylglutathione lyase activity
MX663_03105	COG2259	Doxx family
MX663_03110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MX663_03130	COG2323	membrane
MX663_03135	COG2323	membrane
MX663_03140	COG0071	Belongs to the small heat shock protein (HSP20) family
MX663_03155	COG1309	transcriptional regulator
MX663_03165	COG0456	acetyltransferase
MX663_03175	COG0673	inositol 2-dehydrogenase activity
MX663_03180	COG1609	Transcriptional regulator
MX663_03185	COG2814	Major facilitator Superfamily
MX663_03190	COG1082	Xylose isomerase domain protein TIM barrel
MX663_03195	COG0488	(ABC) transporter
MX663_03200	COG1113	amino acid transport
MX663_03205	COG2318	DinB family
MX663_03210	COG1846	Transcriptional regulator
MX663_03215	COG1033	growth of symbiont in host cell
MX663_03215	COG2409	Drug exporters of the RND superfamily
MX663_03220	COG0778	Nitroreductase
MX663_03225	COG1846	Transcriptional regulator
MX663_03230	COG2814	Major facilitator Superfamily
MX663_03235	COG0730	response to heat
MX663_03240	COG1802	Transcriptional regulator
MX663_03245	COG3858	chitin binding
MX663_03245	COG1388	LysM domain
MX663_03250	COG1819	glycosyl
MX663_03260	COG1785	Belongs to the alkaline phosphatase family
MX663_03265	COG5646	InterPro IPR014922
MX663_03275	COG0454	-acetyltransferase
MX663_03280	COG1078	dGTPase activity
MX663_03285	COG1388	LysM domain
MX663_03290	COG2814	Major facilitator Superfamily
MX663_03295	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MX663_03300	COG1447	Phosphotransferase system cellobiose-specific component IIA
MX663_03305	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MX663_03310	COG2723	6-phospho-beta-galactosidase activity
MX663_03315	COG2188	Transcriptional regulator
MX663_03320	COG1940	carbohydrate kinase activity
MX663_03325	COG1482	cell wall glycoprotein biosynthetic process
MX663_03330	COG4124	Belongs to the glycosyl hydrolase 26 family
MX663_03375	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
MX663_03380	COG0802	atpase or kinase
MX663_03385	COG1214	PFAM Peptidase M22, glycoprotease
MX663_03390	COG0456	acetyltransferase
MX663_03395	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
MX663_03400	COG0488	(ABC) transporter
MX663_03405	COG0315	cyclic pyranopterin monophosphate synthase activity
MX663_03410	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
MX663_03415	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MX663_03420	COG0805	protein transport
MX663_03430	COG1266	CAAX protease self-immunity
MX663_03440	COG0459	protein refolding
MX663_03460	COG1073	alpha beta
MX663_03465	COG0457	Tetratricopeptide repeat
MX663_03470	COG1063	alcohol dehydrogenase
MX663_03475	COG2211	Major facilitator Superfamily
MX663_03480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MX663_03485	COG1842	Phage shock protein A
MX663_03490	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MX663_03495	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
MX663_03500	COG4260	virion core protein, lumpy skin disease virus
MX663_03510	COG2814	Major facilitator Superfamily
MX663_03515	COG1063	alcohol dehydrogenase
MX663_03520	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
MX663_03525	COG0823	Involved in the tonB-independent uptake of proteins
MX663_03540	COG2267	carboxylic ester hydrolase activity
MX663_03550	COG2132	Multicopper oxidase
MX663_03555	COG1113	amino acid transport
MX663_03565	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
MX663_03570	COG0714	Associated with various cellular activities
MX663_03575	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
MX663_03580	COG1305	Transglutaminase-like
MX663_03585	COG0519	Catalyzes the synthesis of GMP from XMP
MX663_03585	COG0518	GMP synthase (glutamine-hydrolyzing) activity
MX663_03600	COG2252	PERMEase
MX663_03605	COG3064	Membrane
MX663_03615	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
MX663_03625	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
MX663_03630	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
MX663_03635	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
MX663_03640	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
MX663_03645	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MX663_03650	COG0047	phosphoribosylformylglycinamidine synthase activity
MX663_03655	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
MX663_03660	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
MX663_03665	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
MX663_03670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
MX663_03675	COG0138	bifunctional purine biosynthesis protein purh
MX663_03680	COG0151	Belongs to the GarS family
MX663_03685	COG1522	sequence-specific DNA binding
MX663_03690	COG0531	amino acid
MX663_03700	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MX663_03705	COG1470	cell adhesion involved in biofilm formation
MX663_03710	COG4496	protein, YerC YecD
MX663_03715	COG0069	glutamate synthase activity
MX663_03720	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
MX663_03725	COG0210	DNA helicase
MX663_03730	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
MX663_03735	COG4851	CamS sex pheromone cAM373 precursor
MX663_03740	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MX663_03745	COG1285	pathogenesis
MX663_03750	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MX663_03755	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MX663_03760	COG0154	amidase activity
MX663_03765	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
MX663_03775	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
MX663_03780	COG1597	lipid kinase activity
MX663_03785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MX663_03810	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
MX663_03825	COG5444	nuclease activity
MX663_03830	COG3391	amine dehydrogenase activity
MX663_03835	COG0457	Tetratricopeptide repeat
MX663_03845	COG0217	transcriptional regulatory protein
MX663_03855	COG1309	transcriptional regulator
MX663_03860	COG3631	Ketosteroid isomerase-related protein
MX663_03880	COG3546	catalase activity
MX663_03885	COG0454	-acetyltransferase
MX663_03895	COG5578	integral membrane protein
MX663_03900	COG2972	Histidine kinase
MX663_03905	COG2207	Transcriptional regulator
MX663_03905	COG4753	response regulator
MX663_03910	COG1653	transport
MX663_03915	COG1175	transmembrane transport
MX663_03920	COG0395	ABC-type sugar transport system, permease component
MX663_03925	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
MX663_03930	COG2207	Transcriptional regulator
MX663_03935	COG2755	lipolytic protein G-D-S-L family
MX663_03945	COG5578	integral membrane protein
MX663_03950	COG3401	FG-GAP repeat protein
MX663_03955	COG3401	FG-GAP repeat protein
MX663_03960	COG2755	lipolytic protein G-D-S-L family
MX663_03965	COG1874	Beta-galactosidase
MX663_03975	COG1653	transport
MX663_03980	COG4209	transmembrane transport
MX663_03985	COG0395	ABC-type sugar transport system, permease component
MX663_03990	COG1486	melibiose metabolic process
MX663_03995	COG2323	membrane
MX663_04000	COG2329	Antibiotic biosynthesis monooxygenase
MX663_04005	COG0346	lactoylglutathione lyase activity
MX663_04020	COG5583	Uncharacterized small protein (DUF2292)
MX663_04025	COG0670	Belongs to the BI1 family
MX663_04035	COG1715	Restriction endonuclease
MX663_04045	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MX663_04045	COG2124	cytochrome p450
MX663_04050	COG1368	sulfuric ester hydrolase activity
MX663_04055	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
MX663_04060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MX663_04065	COG1442	glycosyl transferase family 8
MX663_04070	COG1216	Glycosyl transferase, family 2
MX663_04075	COG1442	glycosyl transferase family 8
MX663_04080	COG2223	nitrite transmembrane transporter activity
MX663_04085	COG1011	Hydrolase
MX663_04090	COG0531	amino acid
MX663_04095	COG1012	belongs to the aldehyde dehydrogenase family
MX663_04100	COG0840	transmembrane signaling receptor activity
MX663_04105	COG0488	(ABC) transporter
MX663_04115	COG0789	Transcriptional regulator
MX663_04120	COG2814	Major facilitator Superfamily
MX663_04135	COG0488	(ABC) transporter
MX663_04140	COG0513	Belongs to the DEAD box helicase family
MX663_04145	COG0456	acetyltransferase
MX663_04150	COG2130	NADP-dependent
MX663_04155	COG2211	Major facilitator Superfamily
MX663_04160	COG1262	PFAM Formylglycine-generating sulfatase enzyme
MX663_04165	COG1120	ATPase activity
MX663_04170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MX663_04175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MX663_04180	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MX663_04195	COG3866	Pectate lyase
MX663_04200	COG0471	metal ion transport
MX663_04205	COG3290	protein histidine kinase activity
MX663_04210	COG4565	transcriptional regulatory protein
MX663_04215	COG3181	Tripartite tricarboxylate transporter family receptor
MX663_04220	COG2851	Citrate transporter
MX663_04225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MX663_04230	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
MX663_04235	COG1254	Belongs to the acylphosphatase family
MX663_04240	COG2258	MOSC domain
MX663_04260	COG0024	Methionine aminopeptidase
MX663_04265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MX663_04265	COG1263	PTS System
MX663_04270	COG1368	sulfuric ester hydrolase activity
MX663_04285	COG1115	amino acid carrier protein
MX663_04290	COG0531	amino acid
MX663_04305	COG0697	spore germination
MX663_04310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MX663_04310	COG1263	PTS System
MX663_04315	COG0366	Alpha amylase catalytic
MX663_04320	COG2188	Transcriptional regulator
MX663_04325	COG0778	Nitroreductase
MX663_04330	COG0737	Belongs to the 5'-nucleotidase family
MX663_04335	COG0693	protein deglycase activity
MX663_04340	COG2814	Major facilitator Superfamily
MX663_04345	COG4840	Belongs to the UPF0435 family
MX663_04350	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MX663_04355	COG4980	gas vesicle protein
MX663_04360	COG1295	ribonuclease BN
MX663_04365	COG0477	Major facilitator Superfamily
MX663_04370	COG0387	Pfam Sodium calcium exchanger
MX663_04380	COG0668	transmembrane transport
MX663_04385	COG0535	radical SAM domain protein
MX663_04395	COG0726	polysaccharide deacetylase
MX663_04400	COG2084	Dehydrogenase
MX663_04405	COG0598	Magnesium transport protein CorA
MX663_04410	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
MX663_04415	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
MX663_04425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
MX663_04430	COG4637	Psort location Cytoplasmic, score
MX663_04440	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MX663_04445	COG0022	dehydrogenase e1 component
MX663_04450	COG0508	dehydrogenase complex catalyzes the overall conversion of
MX663_04455	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MX663_04460	COG3284	Transcriptional regulator
MX663_04470	COG1742	UPF0060 membrane protein
MX663_04490	COG4842	Belongs to the WXG100 family
MX663_04495	COG1486	melibiose metabolic process
MX663_04500	COG1737	Transcriptional regulator
MX663_04505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MX663_04505	COG1263	PTS System
MX663_04510	COG1132	(ABC) transporter
MX663_04515	COG1132	(ABC) transporter
MX663_04520	COG2259	Doxx family
MX663_04525	COG2514	catechol 2,3-dioxygenase activity
MX663_04530	COG1917	Cupin 2, conserved barrel domain protein
MX663_04530	COG4977	sequence-specific DNA binding
MX663_04535	COG2814	Major facilitator Superfamily
MX663_04540	COG1082	Xylose isomerase domain protein TIM barrel
MX663_04545	COG0673	inositol 2-dehydrogenase activity
MX663_04550	COG4585	Histidine kinase
MX663_04555	COG2197	response regulator
MX663_04560	COG1131	(ABC) transporter
MX663_04565	COG0842	Transport permease protein
MX663_04565	COG1511	domain protein
MX663_04570	COG0842	Transport permease protein
MX663_04575	COG1695	Transcriptional regulator
MX663_04580	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
MX663_04585	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
MX663_04590	COG2318	DinB family
MX663_04595	COG2814	Major facilitator Superfamily
MX663_04600	COG1846	Transcriptional regulator
MX663_04605	COG0392	lysyltransferase activity
MX663_04605	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
MX663_04610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MX663_04615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MX663_04620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MX663_04625	COG0384	phenazine biosynthesis protein PhzF
MX663_04630	COG0778	Nitroreductase
MX663_04645	COG1090	epimerase
MX663_04650	COG2137	regulation of response to DNA damage stimulus
MX663_04660	COG2814	Major facilitator Superfamily
MX663_04675	COG3103	Sh3 type 3 domain protein
MX663_04680	COG5658	integral membrane protein
MX663_04685	COG0596	Alpha beta hydrolase
MX663_04690	COG0463	Glycosyl transferase, family 2
MX663_04695	COG4485	Bacterial membrane protein, YfhO
MX663_04700	COG1988	membrane-bound metal-dependent
MX663_04705	COG1194	a g-specific adenine glycosylase
MX663_04715	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_04730	COG3557	Belongs to the UPF0374 family
MX663_04735	COG1132	(ABC) transporter
MX663_04740	COG4129	membrane
MX663_04745	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MX663_04750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
MX663_04755	COG0735	belongs to the Fur family
MX663_04865	COG4326	sporulation control protein
MX663_04875	COG5577	PFAM Coat F domain
MX663_04880	COG3340	Belongs to the peptidase S51 family
MX663_04885	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
MX663_04890	COG0277	FAD linked oxidase domain protein
MX663_04900	COG0753	catalase activity
MX663_04905	COG1116	anion transmembrane transporter activity
MX663_04910	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MX663_04915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MX663_04920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MX663_04930	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
MX663_04940	COG1476	TRANSCRIPTIONal
MX663_04950	COG3382	B3 4 domain protein
MX663_04955	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
MX663_04965	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
MX663_04970	COG0789	Transcriptional regulator
MX663_04975	COG1664	Polymer-forming cytoskeletal
MX663_04980	COG1664	Polymer-forming cytoskeletal
MX663_04985	COG2766	serine protein kinase
MX663_04990	COG2718	Belongs to the UPF0229 family
MX663_04995	COG1846	Transcriptional regulator
MX663_05000	COG1566	PFAM secretion protein HlyD family protein
MX663_05005	COG2814	Major facilitator Superfamily
MX663_05010	COG0655	NAD(P)H dehydrogenase (quinone) activity
MX663_05030	COG1725	Transcriptional regulator
MX663_05035	COG1131	(ABC) transporter
MX663_05040	COG1131	(ABC) transporter
MX663_05045	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MX663_05050	COG1278	Cold shock
MX663_05055	COG1464	Belongs to the NlpA lipoprotein family
MX663_05060	COG3706	GGDEF domain
MX663_05065	COG1823	symporter activity
MX663_05085	COG5577	PFAM Coat F domain
MX663_05090	COG4085	toxin activity
MX663_05090	COG1525	nuclease
MX663_05090	COG0737	Belongs to the 5'-nucleotidase family
MX663_05095	COG3764	Sortase (surface protein transpeptidase)
MX663_05100	COG0564	pseudouridine synthase activity
MX663_05110	COG0517	IMP dehydrogenase activity
MX663_05115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MX663_05120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MX663_05120	COG3153	acetyltransferase
MX663_05125	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MX663_05130	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
MX663_05135	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
MX663_05140	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
MX663_05145	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
MX663_05150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
MX663_05155	COG4585	Histidine kinase
MX663_05155	COG2203	Gaf domain
MX663_05160	COG2197	response regulator
MX663_05165	COG0431	NADPH-dependent FMN reductase
MX663_05180	COG0791	NLP P60 protein
MX663_05180	COG1388	LysM domain
MX663_05185	COG1959	2 iron, 2 sulfur cluster binding
MX663_05190	COG0668	transmembrane transport
MX663_05195	COG2719	SpoVR family
MX663_05205	COG1388	LysM domain
MX663_05205	COG0791	NLP P60 protein
MX663_05210	COG0583	DNA-binding transcription factor activity
MX663_05215	COG0372	Belongs to the citrate synthase family
MX663_05220	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_05225	COG0531	amino acid
MX663_05230	COG0733	neurotransmitter:sodium symporter activity
MX663_05235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MX663_05240	COG0456	acetyltransferase
MX663_05255	COG1595	DNA-templated transcription, initiation
MX663_05260	COG0667	Aldo Keto reductase
MX663_05265	COG0204	Acyl-transferase
MX663_05270	COG1253	flavin adenine dinucleotide binding
MX663_05275	COG0789	Transcriptional regulator
MX663_05280	COG0436	Aminotransferase
MX663_05285	COG1253	flavin adenine dinucleotide binding
MX663_05290	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MX663_05295	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
MX663_05300	COG0584	glycerophosphoryl diester phosphodiesterase
MX663_05310	COG0668	transmembrane transport
MX663_05315	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
MX663_05320	COG0726	polysaccharide deacetylase
MX663_05325	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MX663_05330	COG1757	Na H antiporter
MX663_05335	COG0589	response to stress
MX663_05345	COG1132	(ABC) transporter
MX663_05350	COG1132	(ABC) transporter
MX663_05375	COG0189	ligase activity
MX663_05380	COG0189	ligase activity
MX663_05385	COG4399	Belongs to the UPF0754 family
MX663_05390	COG3679	Belongs to the UPF0342 family
MX663_05395	COG4335	DNA alkylation repair
MX663_05400	COG0561	phosphatase activity
MX663_05405	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MX663_05410	COG0475	glutathione-regulated potassium exporter activity
MX663_05415	COG0490	domain, Protein
MX663_05425	COG1024	Enoyl-CoA hydratase
MX663_05435	COG4152	abc transporter atp-binding protein
MX663_05440	COG1668	transmembrane transport
MX663_05445	COG0420	3'-5' exonuclease activity
MX663_05450	COG4717	serine-type aminopeptidase activity
MX663_05455	COG3481	metal-dependent phosphohydrolase, HD sub domain
MX663_05465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
MX663_05495	COG1846	Transcriptional regulator
MX663_05500	COG4980	gas vesicle protein
MX663_05515	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
MX663_05520	COG0537	adenosine 5'-monophosphoramidase activity
MX663_05525	COG1131	(ABC) transporter
MX663_05530	COG4473	ABC transporter
MX663_05540	COG1473	amidohydrolase
MX663_05545	COG3069	C4-dicarboxylate transmembrane transporter activity
MX663_05555	COG2329	Antibiotic biosynthesis monooxygenase
MX663_05560	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MX663_05565	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
MX663_05570	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
MX663_05575	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
MX663_05580	COG1309	transcriptional regulator
MX663_05585	COG1511	domain protein
MX663_05590	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MX663_05595	COG4377	Putative membrane peptidase family (DUF2324)
MX663_05605	COG1363	Peptidase, m42
MX663_05610	COG4405	Protein conserved in bacteria
MX663_05615	COG1301	dicarboxylic acid transport
MX663_05625	COG1234	tRNA 3'-trailer cleavage
MX663_05630	COG0095	Lipoate-protein ligase
MX663_05635	COG0702	epimerase
MX663_05640	COG0318	PFAM AMP-dependent synthetase and ligase
MX663_05650	COG0501	Belongs to the peptidase M48B family
MX663_05660	COG0456	acetyltransferase
MX663_05665	COG0604	alcohol dehydrogenase
MX663_05670	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
MX663_05675	COG0406	alpha-ribazole phosphatase activity
MX663_05680	COG0183	Belongs to the thiolase family
MX663_05685	COG0318	PFAM AMP-dependent synthetase and ligase
MX663_05690	COG1268	BioY protein
MX663_05695	COG0840	transmembrane signaling receptor activity
MX663_05700	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MX663_05700	COG0723	plastoquinol--plastocyanin reductase activity
MX663_05705	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_05715	COG4903	ComK protein
MX663_05720	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_05730	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MX663_05745	COG0398	Pfam SNARE associated Golgi protein
MX663_05750	COG0681	Belongs to the peptidase S26 family
MX663_05755	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
MX663_05760	COG1846	Transcriptional regulator
MX663_05765	COG0738	Major facilitator superfamily
MX663_05770	COG0673	inositol 2-dehydrogenase activity
MX663_05775	COG0561	phosphatase activity
MX663_05780	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MX663_05785	COG1609	Transcriptional regulator
MX663_05790	COG3180	Ammonia monooxygenase
MX663_05795	COG0477	Major facilitator Superfamily
MX663_05795	COG2814	Major facilitator Superfamily
MX663_05810	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
MX663_05815	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
MX663_05820	COG1074	ATP-dependent DNA helicase activity
MX663_05825	COG0420	3'-5' exonuclease activity
MX663_05830	COG0419	ATPase involved in DNA repair
MX663_05835	COG1403	HNH endonuclease
MX663_05875	COG5337	Spore coat protein CotH
MX663_05880	COG0179	Fumarylacetoacetate (FAA) hydrolase
MX663_05890	COG1404	Belongs to the peptidase S8 family
MX663_05900	COG0367	asparagine synthase
MX663_05905	COG2318	DinB family
MX663_05910	COG1562	ergosterol biosynthetic process
MX663_05915	COG0534	Mate efflux family protein
MX663_05920	COG1917	Cupin 2, conserved barrel domain protein
MX663_05920	COG2207	Transcriptional regulator
MX663_05925	COG1609	Transcriptional regulator
MX663_05930	COG0673	inositol 2-dehydrogenase activity
MX663_05935	COG2318	DinB family
MX663_05945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
MX663_05950	COG1357	PFAM Pentapeptide repeats (8 copies)
MX663_05955	COG2267	carboxylic ester hydrolase activity
MX663_05960	COG0529	Catalyzes the synthesis of activated sulfate
MX663_05965	COG2046	Belongs to the sulfate adenylyltransferase family
MX663_05970	COG0175	sulfate reduction
MX663_05975	COG2045	Belongs to the ComB family
MX663_05980	COG1809	phosphosulfolactate synthase activity
MX663_05985	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MX663_05990	COG4948	Mandelate Racemase Muconate Lactonizing
MX663_05995	COG2814	Major facilitator Superfamily
MX663_06000	COG0454	-acetyltransferase
MX663_06005	COG2153	protein acetylation
MX663_06010	COG0646	methionine synthase
MX663_06010	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
MX663_06015	COG1666	GTP binding
MX663_06020	COG2996	Protein conserved in bacteria
MX663_06040	COG1695	Transcriptional regulator
MX663_06055	COG3227	Zinc metalloprotease (Elastase)
MX663_06060	COG1307	EDD domain protein, DegV family
MX663_06065	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MX663_06085	COG0561	phosphatase activity
MX663_06090	COG1073	alpha beta
MX663_06095	COG2151	metal-sulfur cluster biosynthetic enzyme
MX663_06105	COG0277	FAD linked oxidase domain protein
MX663_06110	COG2271	Major facilitator Superfamily
MX663_06115	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
MX663_06120	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
MX663_06130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MX663_06135	COG0505	Belongs to the CarA family
MX663_06140	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MX663_06145	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
MX663_06160	COG2267	carboxylic ester hydrolase activity
MX663_06170	COG1744	ABC transporter substrate-binding protein PnrA-like
MX663_06185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MX663_06190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MX663_06195	COG5504	Zn-dependent protease
MX663_06200	COG0444	Belongs to the ABC transporter superfamily
MX663_06205	COG4608	Belongs to the ABC transporter superfamily
MX663_06215	COG0601	transmembrane transport
MX663_06220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MX663_06230	COG0180	Tryptophanyl-tRNA synthetase
MX663_06240	COG0601	transmembrane transport
MX663_06245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MX663_06250	COG0444	Belongs to the ABC transporter superfamily
MX663_06255	COG4608	Belongs to the ABC transporter superfamily
MX663_06260	COG2814	Major facilitator Superfamily
MX663_06265	COG0456	acetyltransferase
MX663_06270	COG1393	Belongs to the ArsC family
MX663_06275	COG0861	Integral membrane protein TerC family
MX663_06285	COG4862	establishment of competence for transformation
MX663_06295	COG4469	Competence protein
MX663_06300	COG1164	Oligoendopeptidase f
MX663_06310	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MX663_06315	COG2346	COG2346, Truncated hemoglobins
MX663_06320	COG0741	lytic transglycosylase activity
MX663_06325	COG4116	CYTH
MX663_06335	COG2357	RelA SpoT domain protein
MX663_06340	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MX663_06345	COG0564	pseudouridine synthase activity
MX663_06350	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
MX663_06355	COG0475	glutathione-regulated potassium exporter activity
MX663_06355	COG0569	domain protein
MX663_06360	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
MX663_06365	COG0352	thiamine-phosphate diphosphorylase activity
MX663_06370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MX663_06375	COG2104	thiamine diphosphate biosynthetic process
MX663_06380	COG2022	thiamine diphosphate biosynthetic process
MX663_06385	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MX663_06390	COG0351	phosphomethylpyrimidine kinase
MX663_06395	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
MX663_06450	COG0210	DNA helicase
MX663_06460	COG2153	protein acetylation
MX663_06465	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MX663_06470	COG2382	esterase
MX663_06475	COG0626	cystathionine gamma-synthase activity
MX663_06480	COG0626	cystathionine gamma-synthase activity
MX663_06485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MX663_06505	COG5444	nuclease activity
MX663_06550	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
MX663_06555	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_06565	COG3711	transcriptional antiterminator
MX663_06565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MX663_06570	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MX663_06570	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MX663_06570	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MX663_06575	COG1482	cell wall glycoprotein biosynthetic process
MX663_06585	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MX663_06595	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
MX663_06610	COG0109	protoheme IX farnesyltransferase activity
MX663_06620	COG0726	polysaccharide deacetylase
MX663_06635	COG5504	Zn-dependent protease
MX663_06640	COG2205	protein histidine kinase activity
MX663_06650	COG3383	formate dehydrogenase (NAD+) activity
MX663_06655	COG2427	Protein of unknown function (DUF1641)
MX663_06665	COG1051	belongs to the nudix hydrolase family
MX663_06675	COG2124	cytochrome p450
MX663_06680	COG1819	glycosyl
MX663_06690	COG1587	Uroporphyrinogen-III synthase
MX663_06695	COG0390	transport system, permease component
MX663_06700	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MX663_06705	COG0697	spore germination
MX663_06710	COG4297	protein containing double-stranded beta helix domain
MX663_06720	COG1252	NADH dehydrogenase
MX663_06725	COG1904	glucuronate isomerase
MX663_06730	COG2211	Major facilitator Superfamily
MX663_06735	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
MX663_06740	COG1063	alcohol dehydrogenase
MX663_06745	COG1312	Catalyzes the dehydration of D-mannonate
MX663_06750	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_06755	COG2271	Major facilitator Superfamily
MX663_06760	COG1609	Transcriptional regulator
MX663_06765	COG0246	Mannitol dehydrogenase
MX663_06770	COG2721	sulfolactate sulfo-lyase activity
MX663_06775	COG0730	response to heat
MX663_06780	COG2318	DinB family
MX663_06785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
MX663_06790	COG0457	Tetratricopeptide repeat
MX663_06800	COG2350	Protein conserved in bacteria
MX663_06805	COG1388	LysM domain
MX663_06805	COG5632	N-Acetylmuramoyl-L-alanine amidase
MX663_06805	COG3409	Peptidoglycan-binding domain 1 protein
MX663_06815	COG4195	phage-related replication protein
MX663_06820	COG3546	catalase activity
MX663_06825	COG2856	Zn peptidase
MX663_06830	COG1396	sequence-specific DNA binding
MX663_06840	COG1522	sequence-specific DNA binding
MX663_06845	COG1484	DNA-dependent DNA replication
MX663_06865	COG1595	DNA-templated transcription, initiation
MX663_06870	COG5484	DNA packaging
MX663_06870	COG3728	DNA packaging
MX663_06875	COG1783	phage Terminase large subunit
MX663_06880	COG5518	Phage portal protein
MX663_06885	COG0338	D12 class N6 adenine-specific DNA methyltransferase
MX663_06890	COG4653	Phage capsid family
MX663_06940	COG5412	phage tail tape measure protein
MX663_06940	COG3953	SLT domain
MX663_06945	COG1652	LysM domain
MX663_06950	COG4193	domain, Protein
MX663_06960	COG3628	GPW Gp25 family protein
MX663_06965	COG3299	homolog of phage Mu protein gp47
MX663_06970	COG3778	Protein conserved in bacteria
MX663_07010	COG5632	N-Acetylmuramoyl-L-alanine amidase
MX663_07010	COG3409	Peptidoglycan-binding domain 1 protein
MX663_07030	COG0306	phosphate transporter
MX663_07035	COG1392	Phosphate transport regulator
MX663_07040	COG0531	amino acid
MX663_07045	COG0346	lactoylglutathione lyase activity
MX663_07055	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MX663_07060	COG0463	Glycosyl transferase, family 2
MX663_07070	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MX663_07075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MX663_07080	COG2362	D-Aminopeptidase
MX663_07085	COG0601	transmembrane transport
MX663_07090	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
MX663_07095	COG0444	Belongs to the ABC transporter superfamily
MX663_07100	COG4166	transmembrane transport
MX663_07105	COG1619	proteins homologs of microcin C7 resistance protein MccF
MX663_07110	COG4948	Mandelate Racemase Muconate Lactonizing
MX663_07115	COG0791	NLP P60 protein
MX663_07120	COG4608	Belongs to the ABC transporter superfamily
MX663_07125	COG2706	6-phosphogluconolactonase activity
MX663_07130	COG1834	amidinotransferase
MX663_07135	COG1607	acyl-coa hydrolase
MX663_07140	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
MX663_07140	COG1017	nitric oxide dioxygenase activity
MX663_07150	COG2323	membrane
MX663_07155	COG2318	DinB family
MX663_07160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MX663_07165	COG2076	Multidrug Resistance protein
MX663_07170	COG2076	Multidrug Resistance protein
MX663_07175	COG0788	formyltetrahydrofolate deformylase activity
MX663_07180	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MX663_07185	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
MX663_07190	COG1764	response to oxidative stress
MX663_07195	COG1846	Transcriptional regulator
MX663_07200	COG1764	response to oxidative stress
MX663_07210	COG0590	tRNA wobble adenosine to inosine editing
MX663_07220	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MX663_07225	COG1404	Belongs to the peptidase S8 family
MX663_07230	COG1366	Belongs to the anti-sigma-factor antagonist family
MX663_07235	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
MX663_07240	COG1122	ATPase activity
MX663_07245	COG4721	ABC-type cobalt transport system, permease component
MX663_07255	COG0745	RESPONSE REGULATOR receiver
MX663_07260	COG5002	protein histidine kinase activity
MX663_07260	COG3850	Histidine kinase
MX663_07265	COG3212	peptidase
MX663_07270	COG3212	peptidase
MX663_07280	COG2239	Acts as a magnesium transporter
MX663_07285	COG0789	Transcriptional regulator
MX663_07300	COG1846	Transcriptional regulator
MX663_07305	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MX663_07310	COG0726	polysaccharide deacetylase
MX663_07315	COG1408	metallophosphoesterase
MX663_07325	COG0463	Glycosyl transferase, family 2
MX663_07330	COG3285	dna ligase
MX663_07330	COG1793	dna ligase
MX663_07335	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
MX663_07340	COG5001	Diguanylate cyclase
MX663_07340	COG3300	MHYT domain
MX663_07345	COG0586	Pfam SNARE associated Golgi protein
MX663_07350	COG0861	Integral membrane protein TerC family
MX663_07355	COG1191	sigma factor activity
MX663_07375	COG0501	Belongs to the peptidase M48B family
MX663_07380	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MX663_07395	COG3594	Acyltransferase
MX663_07400	COG5002	protein histidine kinase activity
MX663_07405	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
MX663_07415	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
MX663_07420	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
MX663_07425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
MX663_07430	COG0436	Aminotransferase
MX663_07435	COG1850	ribulose-bisphosphate carboxylase activity
MX663_07440	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
MX663_07445	COG0235	Class ii aldolase
MX663_07450	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
MX663_07455	COG3339	Conserved Protein
MX663_07470	COG3852	Histidine kinase
MX663_07475	COG1846	Transcriptional regulator
MX663_07480	COG1360	Flagellar Motor Protein
MX663_07485	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MX663_07490	COG0542	response to heat
MX663_07495	COG3949	Membrane
MX663_07500	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
MX663_07505	COG0720	synthase
MX663_07510	COG0602	queuosine metabolic process
MX663_07515	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
MX663_07520	COG1733	regulation of RNA biosynthetic process
MX663_07525	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_07530	COG4641	Protein conserved in bacteria
MX663_07530	COG1388	LysM domain
MX663_07535	COG1388	LysM domain
MX663_07540	COG3858	chitin binding
MX663_07550	COG4873	Protein conserved in bacteria
MX663_07560	COG3773	Cell wall hydrolase
MX663_07565	COG2244	polysaccharide biosynthetic process
MX663_07570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MX663_07575	COG2217	Heavy metal translocating P-type atpase
MX663_07585	COG0006	proline dipeptidase activity
MX663_07590	COG1609	Transcriptional regulator
MX663_07595	COG3711	transcriptional antiterminator
MX663_07600	COG1263	PTS System
MX663_07600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MX663_07600	COG2190	(PTS) system
MX663_07605	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MX663_07610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
MX663_07620	COG1533	DNA photolyase activity
MX663_07625	COG0456	acetyltransferase
MX663_07630	COG0840	transmembrane signaling receptor activity
MX663_07635	COG2084	Dehydrogenase
MX663_07640	COG2340	Cysteine-rich secretory protein family
MX663_07645	COG0768	penicillin binding
MX663_07650	COG4191	Histidine kinase
MX663_07655	COG0436	Aminotransferase
MX663_07665	COG0835	chemotaxis
MX663_07665	COG0784	Response regulator, receiver
MX663_07675	COG2814	Major facilitator Superfamily
MX663_07680	COG1376	ErfK ybiS ycfS ynhG family protein
MX663_07685	COG1408	metallophosphoesterase
MX663_07690	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_07695	COG2200	EAL domain
MX663_07700	COG4703	Protein of unknown function (DUF1797)
MX663_07705	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
MX663_07715	COG0517	IMP dehydrogenase activity
MX663_07720	COG0583	DNA-binding transcription factor activity
MX663_07725	COG0716	FMN binding
MX663_07735	COG0716	FMN binding
MX663_07740	COG2171	N-acyltransferase activity
MX663_07745	COG1473	amidohydrolase
MX663_07755	COG0668	transmembrane transport
MX663_07760	COG0450	alkyl hydroperoxide reductase
MX663_07765	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MX663_07780	COG0746	molybdenum cofactor guanylyltransferase activity
MX663_07785	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
MX663_07790	COG0303	'Molybdopterin
MX663_07795	COG1763	Mo-molybdopterin cofactor biosynthetic process
MX663_07800	COG0314	molybdopterin synthase activity
MX663_07805	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
MX663_07810	COG1132	(ABC) transporter
MX663_07815	COG1132	(ABC) transporter
MX663_07825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MX663_07830	COG1136	(ABC) transporter
MX663_07835	COG0577	efflux transmembrane transporter activity
MX663_07840	COG1349	DNA-binding transcription factor activity
MX663_07845	COG1105	Belongs to the carbohydrate kinase PfkB family
MX663_07850	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MX663_07850	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MX663_07850	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
MX663_07855	COG0681	Belongs to the peptidase S26 family
MX663_07865	COG0488	(ABC) transporter
MX663_07870	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MX663_07875	COG2309	aminopeptidase activity
MX663_07885	COG1077	Cell shape determining protein MreB Mrl
MX663_07890	COG2002	toxin-antitoxin pair type II binding
MX663_07895	COG3852	Histidine kinase
MX663_07900	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
MX663_07900	COG2105	PFAM AIG2 family protein
MX663_07905	COG0569	domain protein
MX663_07910	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
MX663_07915	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MX663_07920	COG5503	Protein of unknown function (DUF1447)
MX663_07925	COG0561	phosphatase activity
MX663_07930	COG0242	peptide deformylase activity
MX663_07940	COG0497	DNA recombination
MX663_07945	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MX663_07950	COG0022	dehydrogenase e1 component
MX663_07955	COG0508	dehydrogenase complex catalyzes the overall conversion of
MX663_07960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MX663_07965	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MX663_07975	COG1982	Orn Lys Arg decarboxylase major
MX663_07980	COG4476	Belongs to the UPF0223 family
MX663_07985	COG4493	Belongs to the UPF0637 family
MX663_07995	COG0483	inositol monophosphate 1-phosphatase activity
MX663_08005	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
MX663_08025	COG1595	DNA-templated transcription, initiation
MX663_08045	COG1217	gtp-binding protein TYPA
MX663_08055	COG4896	Protein conserved in bacteria
MX663_08065	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
MX663_08070	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MX663_08075	COG2066	Belongs to the glutaminase family
MX663_08080	COG4838	Belongs to the UPF0358 family
MX663_08085	COG0772	Belongs to the SEDS family
MX663_08090	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
MX663_08095	COG1612	heme a metabolic process
MX663_08100	COG0109	protoheme IX farnesyltransferase activity
MX663_08105	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MX663_08105	COG2010	Cytochrome c
MX663_08110	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MX663_08115	COG1845	cytochrome c oxidase, subunit III
MX663_08120	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MX663_08125	COG3336	cytochrome c oxidase
MX663_08135	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
MX663_08140	COG2340	Cysteine-rich secretory protein family
MX663_08155	COG3679	Belongs to the UPF0342 family
MX663_08160	COG4471	UPF0298 protein
MX663_08165	COG0742	ribosomal rna small subunit methyltransferase
MX663_08170	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
MX663_08175	COG3314	Sporulation integral membrane protein YlbJ
MX663_08180	COG1752	Esterase of the alpha-beta hydrolase superfamily
MX663_08185	COG3480	Lon protease (S16) C-terminal proteolytic domain
MX663_08190	COG1323	Belongs to the UPF0348 family
MX663_08200	COG1399	metal-binding, possibly nucleic acid-binding protein
MX663_08215	COG0454	-acetyltransferase
MX663_08220	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
MX663_08225	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
MX663_08230	COG2001	Belongs to the MraZ family
MX663_08235	COG0275	rRNA processing
MX663_08240	COG4839	cell division protein FtsL
MX663_08245	COG0768	penicillin binding
MX663_08250	COG0768	penicillin binding
MX663_08255	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
MX663_08260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MX663_08265	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MX663_08270	COG0772	Belongs to the SEDS family
MX663_08275	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MX663_08280	COG0812	UDP-N-acetylmuramate dehydrogenase activity
MX663_08285	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
MX663_08290	COG3879	Bacterial protein of unknown function (DUF881)
MX663_08295	COG3879	Bacterial protein of unknown function (DUF881)
MX663_08300	COG3856	small basic protein
MX663_08305	COG0849	cell division
MX663_08310	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
MX663_08315	COG1404	Belongs to the peptidase S8 family
MX663_08315	COG4412	M6 family metalloprotease domain protein
MX663_08325	COG1191	sigma factor activity
MX663_08330	COG1191	sigma factor activity
MX663_08335	COG1119	ATPase activity
MX663_08340	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MX663_08345	COG1873	PFAM PRC-barrel domain
MX663_08350	COG1496	oxidoreductase activity
MX663_08355	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
MX663_08360	COG1799	cell septum assembly
MX663_08365	COG0762	integral membrane protein
MX663_08370	COG2302	S4 RNA-binding domain
MX663_08375	COG3599	regulation of cell shape
MX663_08380	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
MX663_08385	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MX663_08390	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
MX663_08395	COG0564	pseudouridine synthase activity
MX663_08400	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
MX663_08405	COG2233	PERMEase
MX663_08410	COG0540	Belongs to the ATCase OTCase family
MX663_08415	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MX663_08420	COG0505	Belongs to the CarA family
MX663_08425	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
MX663_08430	COG0543	2 iron, 2 sulfur cluster binding
MX663_08435	COG0167	dihydroorotate dehydrogenase activity
MX663_08440	COG0284	orotidine-5'-phosphate decarboxylase activity
MX663_08445	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
MX663_08450	COG0175	sulfate reduction
MX663_08455	COG0306	phosphate transporter
MX663_08460	COG2046	Belongs to the sulfate adenylyltransferase family
MX663_08465	COG0529	Catalyzes the synthesis of activated sulfate
MX663_08470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
MX663_08475	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
MX663_08480	COG1648	precorrin-2 dehydrogenase activity
MX663_08485	COG1293	RNA-binding protein homologous to eukaryotic snRNP
MX663_08490	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MX663_08495	COG1561	YicC-like family, N-terminal region
MX663_08505	COG0194	GDP metabolic process
MX663_08510	COG1758	RNA polymerase activity
MX663_08515	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MX663_08520	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
MX663_08525	COG0242	peptide deformylase activity
MX663_08530	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
MX663_08535	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MX663_08535	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
MX663_08540	COG0820	rRNA (adenine-C2-)-methyltransferase activity
MX663_08545	COG0631	protein serine/threonine phosphatase activity
MX663_08550	COG2815	serine threonine protein kinase
MX663_08550	COG0515	serine threonine protein kinase
MX663_08555	COG1162	GTPase activity
MX663_08560	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
MX663_08565	COG1564	THIamine pyrophosphokinase
MX663_08575	COG0227	Belongs to the bacterial ribosomal protein bL28 family
MX663_08580	COG1302	Protein conserved in bacteria
MX663_08585	COG1461	Dihydroxyacetone kinase
MX663_08590	COG1760	l-serine dehydratase
MX663_08595	COG1760	l-serine dehydratase
MX663_08600	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
MX663_08605	COG1349	DNA-binding transcription factor activity
MX663_08605	COG2050	protein possibly involved in aromatic compounds catabolism
MX663_08610	COG0416	fatty acid biosynthetic process
MX663_08615	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MX663_08620	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_08630	COG0571	ribonuclease III activity
MX663_08635	COG1196	nuclear chromosome segregation
MX663_08640	COG0552	protein localization to endoplasmic reticulum
MX663_08650	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
MX663_08655	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
MX663_08660	COG0228	four-way junction DNA binding
MX663_08665	COG1837	Belongs to the UPF0109 family
MX663_08675	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
MX663_08680	COG0336	Belongs to the RNA methyltransferase TrmD family
MX663_08685	COG0335	large ribosomal subunit rRNA binding
MX663_08690	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MX663_08695	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MX663_08705	COG2257	FlhB HrpN YscU SpaS Family
MX663_08710	COG0045	succinate-CoA ligase (ADP-forming) activity
MX663_08715	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
MX663_08720	COG0758	DNA mediated transformation
MX663_08725	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
MX663_08730	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
MX663_08735	COG4974	Belongs to the 'phage' integrase family
MX663_08740	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
MX663_08745	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
MX663_08750	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
MX663_08755	COG1815	bacterial-type flagellum-dependent cell motility
MX663_08760	COG1558	bacterial-type flagellum-dependent cell motility
MX663_08765	COG1677	Flagellar hook-basal body complex protein FliE
MX663_08770	COG1766	The M ring may be actively involved in energy transduction
MX663_08775	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MX663_08780	COG1317	bacterial-type flagellum organization
MX663_08785	COG1157	protein secretion by the type III secretion system
MX663_08790	COG2882	bacterial-type flagellum organization
MX663_08795	COG3334	PFAM MgtE intracellular
MX663_08800	COG3144	bacterial-type flagellum assembly
MX663_08805	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
MX663_08810	COG4786	Flagellar basal body rod
MX663_08815	COG1582	Flagellar protein (FlbD)
MX663_08820	COG1580	Controls the rotational direction of flagella during chemotaxis
MX663_08825	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MX663_08830	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
MX663_08830	COG1776	CheC inhibitor of MCP methylation
MX663_08835	COG2201	protein-glutamate methylesterase activity
MX663_08840	COG3190	flagellar
MX663_08845	COG1338	Plays a role in the flagellum-specific transport system
MX663_08850	COG1987	bacterial-type flagellum assembly
MX663_08855	COG1684	flagellar biosynthetic protein fliR
MX663_08860	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MX663_08865	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
MX663_08870	COG1419	protein localization to endoplasmic reticulum
MX663_08875	COG0455	bacterial-type flagellum organization
MX663_08880	COG2201	protein-glutamate methylesterase activity
MX663_08885	COG2198	Histidine kinase
MX663_08885	COG0643	Histidine kinase
MX663_08890	COG0835	chemotaxis
MX663_08895	COG1776	CheC inhibitor of MCP methylation
MX663_08900	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
MX663_08905	COG1191	sigma factor activity
MX663_08915	COG0052	Belongs to the universal ribosomal protein uS2 family
MX663_08920	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
MX663_08925	COG0528	UMP kinase activity
MX663_08930	COG0233	cytoplasmic translational termination
MX663_08935	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
MX663_08940	COG4589	Belongs to the CDS family
MX663_08945	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
MX663_08950	COG0750	zinc metalloprotease
MX663_08955	COG0442	prolyl-tRNA aminoacylation
MX663_08960	COG2176	DNA-directed DNA polymerase activity
MX663_08965	COG0779	Required for maturation of 30S ribosomal subunits
MX663_08970	COG0195	Participates in both transcription termination and antitermination
MX663_08975	COG2740	Nucleic-acid-binding protein implicated in transcription termination
MX663_08980	COG1358	cellular component organization or biogenesis
MX663_08985	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
MX663_08990	COG1550	Protein conserved in bacteria
MX663_08995	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
MX663_09000	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
MX663_09005	COG0196	riboflavin kinase activity
MX663_09010	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
MX663_09015	COG1185	polyribonucleotide nucleotidyltransferase activity
MX663_09020	COG0726	polysaccharide deacetylase
MX663_09025	COG0612	Peptidase, M16
MX663_09030	COG1873	PFAM PRC-barrel domain
MX663_09035	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MX663_09040	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
MX663_09045	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
MX663_09050	COG0527	aspartate kinase activity
MX663_09055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
MX663_09060	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
MX663_09065	COG0740	serine-type endopeptidase activity
MX663_09075	COG4980	gas vesicle protein
MX663_09075	COG1674	ftsk spoiiie
MX663_09080	COG2188	Transcriptional regulator
MX663_09085	COG2814	Major facilitator Superfamily
MX663_09090	COG0612	Peptidase, M16
MX663_09095	COG0612	Peptidase, M16
MX663_09100	COG0300	oxidoreductase activity
MX663_09115	COG1426	Protein conserved in bacteria
MX663_09120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
MX663_09125	COG1058	Belongs to the CinA family
MX663_09125	COG1546	Belongs to the CinA family
MX663_09130	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
MX663_09135	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MX663_09140	COG1418	mRNA catabolic process
MX663_09145	COG1692	metallophosphoesterase
MX663_09150	COG2359	stage V sporulation protein S
MX663_09155	COG1063	alcohol dehydrogenase
MX663_09160	COG0156	8-amino-7-oxononanoate synthase activity
MX663_09165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MX663_09170	COG4550	Control of competence regulator ComK, YlbF/YmcA
MX663_09180	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
MX663_09185	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
MX663_09200	COG3226	Transcriptional regulator
MX663_09205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MX663_09215	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MX663_09220	COG3321	synthase
MX663_09225	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
MX663_09225	COG2070	2-Nitropropane dioxygenase
MX663_09230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MX663_09235	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MX663_09240	COG3425	synthase
MX663_09245	COG1024	Enoyl-CoA hydratase
MX663_09250	COG1024	Enoyl-CoA hydratase
MX663_09255	COG0300	oxidoreductase activity
MX663_09255	COG0318	PFAM AMP-dependent synthetase and ligase
MX663_09255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MX663_09255	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_09255	COG3321	synthase
MX663_09260	COG4221	oxidoreductase activity
MX663_09260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MX663_09260	COG0300	oxidoreductase activity
MX663_09260	COG3321	synthase
MX663_09265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MX663_09265	COG3321	synthase
MX663_09265	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_09265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MX663_09265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MX663_09270	COG4221	oxidoreductase activity
MX663_09270	COG3321	synthase
MX663_09270	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_09270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MX663_09275	COG3321	synthase
MX663_09275	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
MX663_09275	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
MX663_09275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MX663_09280	COG2124	cytochrome p450
MX663_09290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MX663_09295	COG1404	Belongs to the peptidase S8 family
MX663_09305	COG4195	phage-related replication protein
MX663_09310	COG1764	response to oxidative stress
MX663_09315	COG2076	Multidrug Resistance protein
MX663_09320	COG2076	Multidrug Resistance protein
MX663_09335	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
MX663_09340	COG1923	regulation of RNA biosynthetic process
MX663_09355	COG1780	Probably involved in ribonucleotide reductase function
MX663_09360	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MX663_09365	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MX663_09370	COG4112	unkown
MX663_09375	COG0860	N-Acetylmuramoyl-L-alanine amidase
MX663_09395	COG1525	nuclease
MX663_09405	COG4282	regulation of fungal-type cell wall biogenesis
MX663_09415	COG5444	nuclease activity
MX663_09425	COG3344	reverse transcriptase
MX663_09455	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MX663_09465	COG0457	Tetratricopeptide repeat
MX663_09480	COG5632	N-Acetylmuramoyl-L-alanine amidase
MX663_09495	COG2433	Pfam Transposase IS66
MX663_09505	COG1196	nuclear chromosome segregation
MX663_09505	COG0741	lytic transglycosylase activity
MX663_09505	COG0739	heme binding
MX663_09525	COG0582	viral genome integration into host DNA
MX663_09625	COG4373	Mu-like prophage FluMu protein gp28
MX663_09665	COG0776	regulation of translation
MX663_09750	COG3655	Transcriptional regulator
MX663_09845	COG0582	viral genome integration into host DNA
MX663_09860	COG3655	Transcriptional regulator
MX663_09905	COG3646	Phage regulatory protein
MX663_09905	COG3645	SOS response
MX663_09930	COG4474	Belongs to the UPF0398 family
MX663_09975	COG1793	dna ligase
MX663_09980	COG2135	peptidase activity
MX663_09995	COG4195	phage-related replication protein
MX663_10000	COG5434	Belongs to the glycosyl hydrolase 28 family
MX663_10000	COG3420	alginic acid biosynthetic process
MX663_10025	COG2887	Belongs to the helicase family. UvrD subfamily
MX663_10035	COG0305	Participates in initiation and elongation during chromosome replication
MX663_10040	COG0358	DNA primase activity
MX663_10045	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MX663_10050	COG0587	DNA-directed DNA polymerase activity
MX663_10055	COG3584	3D domain protein
MX663_10080	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
MX663_10180	COG1780	Probably involved in ribonucleotide reductase function
MX663_10185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
MX663_10185	COG1372	Participates in initiation and elongation during chromosome replication
MX663_10210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MX663_10220	COG0756	dUTP diphosphatase activity
MX663_10245	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MX663_10280	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MX663_10335	COG3331	DNA recombination
MX663_10355	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
MX663_10360	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
MX663_10365	COG0789	Transcriptional regulator
MX663_10370	COG0174	glutamine synthetase
MX663_10375	COG4974	Belongs to the 'phage' integrase family
MX663_10395	COG4824	toxin secretion phage lysis holin
MX663_10400	COG5632	N-Acetylmuramoyl-L-alanine amidase
MX663_10400	COG3409	Peptidoglycan-binding domain 1 protein
MX663_10410	COG5444	nuclease activity
MX663_10520	COG4282	regulation of fungal-type cell wall biogenesis
MX663_10535	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MX663_10555	COG3655	Transcriptional regulator
MX663_10570	COG0135	phosphoribosylanthranilate isomerase activity
MX663_10575	COG2211	Major facilitator Superfamily
MX663_10580	COG3507	Belongs to the glycosyl hydrolase 43 family
MX663_10585	COG1940	carbohydrate kinase activity
MX663_10590	COG2115	Belongs to the xylose isomerase family
MX663_10595	COG1070	Carbohydrate kinase
MX663_10605	COG1525	nuclease
MX663_10610	COG2814	Major facilitator Superfamily
MX663_10615	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
MX663_10625	COG0756	dUTP diphosphatase activity
MX663_10640	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MX663_10665	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
MX663_10680	COG3832	glyoxalase III activity
MX663_10690	COG0697	spore germination
MX663_10695	COG0531	amino acid
MX663_10725	COG4195	phage-related replication protein
MX663_10735	COG0346	lactoylglutathione lyase activity
MX663_10745	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
MX663_10750	COG1388	LysM domain
MX663_10755	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MX663_10760	COG4224	UPF0291 protein
MX663_10765	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
MX663_10775	COG3763	UPF0154 protein
MX663_10785	COG0785	Cytochrome C biogenesis protein
MX663_10790	COG2201	protein-glutamate methylesterase activity
MX663_10795	COG4846	Membrane protein involved in cytochrome C biogenesis
MX663_10805	COG0071	Belongs to the small heat shock protein (HSP20) family
MX663_10820	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
MX663_10825	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MX663_10845	COG0824	Thioesterase
MX663_10855	COG4841	protein insertion into membrane
MX663_10860	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
MX663_10865	COG1832	CoA-binding protein
MX663_10870	COG0187	DNA topoisomerase II activity
MX663_10875	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
MX663_10885	COG1115	amino acid carrier protein
MX663_10890	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
MX663_10900	COG5520	Belongs to the glycosyl hydrolase 30 family
MX663_10905	COG3507	Belongs to the glycosyl hydrolase 43 family
MX663_10910	COG2246	polysaccharide biosynthetic process
MX663_10915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MX663_10920	COG0586	Pfam SNARE associated Golgi protein
MX663_10925	COG2404	hydrolase activity, acting on ester bonds
MX663_10930	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MX663_10935	COG1024	Enoyl-CoA hydratase
MX663_10940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MX663_10945	COG0511	ligase activity, forming carbon-carbon bonds
MX663_10950	COG0439	Biotin carboxylase
MX663_10955	COG0318	PFAM AMP-dependent synthetase and ligase
MX663_10960	COG1960	acyl-CoA dehydrogenase activity
MX663_10975	COG1649	PFAM Uncharacterised BCR, COG1649
MX663_10985	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
MX663_10985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MX663_10990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MX663_10995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MX663_11000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MX663_11005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MX663_11010	COG2027	D-alanyl-D-alanine carboxypeptidase
MX663_11015	COG2017	converts alpha-aldose to the beta-anomer
MX663_11020	COG0534	Mate efflux family protein
MX663_11035	COG0582	viral genome integration into host DNA
MX663_11040	COG0166	Belongs to the GPI family
MX663_11045	COG0405	Gamma-glutamyltransferase
MX663_11050	COG0583	DNA-binding transcription factor activity
MX663_11055	COG0604	alcohol dehydrogenase
MX663_11060	COG0493	'glutamate synthase
MX663_11065	COG0070	glutamate synthase
MX663_11065	COG0069	glutamate synthase activity
MX663_11065	COG0067	glutamate synthase
MX663_11070	COG0583	DNA-binding transcription factor activity
MX663_11075	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
MX663_11080	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MX663_11090	COG0300	oxidoreductase activity
MX663_11095	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
MX663_11105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
MX663_11110	COG2814	Major facilitator Superfamily
MX663_11115	COG1070	Carbohydrate kinase
MX663_11120	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MX663_11125	COG0243	molybdopterin cofactor binding
MX663_11135	COG2814	Major facilitator Superfamily
MX663_11140	COG0673	inositol 2-dehydrogenase activity
MX663_11145	COG1082	Xylose isomerase domain protein TIM barrel
MX663_11150	COG1609	Transcriptional regulator
MX663_11165	COG5278	phosphoserine phosphatase activity
MX663_11165	COG0840	transmembrane signaling receptor activity
MX663_11170	COG2368	4-hydroxyphenylacetate
MX663_11175	COG4305	rare lipoprotein A
MX663_11180	COG3619	membrane
MX663_11185	COG3866	Pectate lyase
MX663_11190	COG2135	peptidase activity
MX663_11200	COG2140	Oxalate decarboxylase
MX663_11235	COG2720	vancomycin resistance protein
MX663_11250	COG3739	integral membrane protein
MX663_11255	COG0583	DNA-binding transcription factor activity
MX663_11260	COG0697	spore germination
MX663_11270	COG0693	protein deglycase activity
MX663_11275	COG2367	Beta-lactamase
MX663_11295	COG0574	Belongs to the PEP-utilizing enzyme family
MX663_11295	COG3848	Pyruvate phosphate dikinase
MX663_11300	COG0726	polysaccharide deacetylase
MX663_11365	COG1404	Belongs to the peptidase S8 family
MX663_11395	COG0457	Tetratricopeptide repeat
MX663_11420	COG4282	regulation of fungal-type cell wall biogenesis
MX663_11425	COG1231	oxidoreductase activity
MX663_11430	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MX663_11435	COG2207	Transcriptional regulator
MX663_11435	COG0662	Cupin 2, conserved barrel domain protein
MX663_11440	COG0456	acetyltransferase
MX663_11445	COG1309	transcriptional regulator
MX663_11450	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MX663_11455	COG3708	Transcriptional regulator
MX663_11460	COG2378	regulation of single-species biofilm formation
MX663_11470	COG0640	Transcriptional regulator
MX663_11475	COG0741	lytic transglycosylase activity
MX663_11480	COG2322	membrane
MX663_11495	COG1619	proteins homologs of microcin C7 resistance protein MccF
MX663_11500	COG3239	Fatty acid desaturase
MX663_11505	COG4585	Histidine kinase
MX663_11510	COG2197	response regulator
MX663_11515	COG3584	3D domain protein
MX663_11515	COG1388	LysM domain
MX663_11520	COG0514	ATP-dependent DNA helicase (RecQ)
MX663_11530	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MX663_11535	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MX663_11550	COG0071	Belongs to the small heat shock protein (HSP20) family
MX663_11575	COG1012	belongs to the aldehyde dehydrogenase family
MX663_11580	COG1657	PFAM Prenyltransferase squalene oxidase
MX663_11585	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MX663_11590	COG0733	neurotransmitter:sodium symporter activity
MX663_11595	COG0385	Bile acid
MX663_11600	COG0508	dehydrogenase complex catalyzes the overall conversion of
MX663_11605	COG0567	Dehydrogenase, E1 component
MX663_11610	COG4548	von Willebrand factor, type A
MX663_11615	COG0714	Associated with various cellular activities
MX663_11620	COG2032	superoxide dismutase activity
MX663_11625	COG0791	NLP P60 protein
MX663_11625	COG1388	LysM domain
MX663_11630	COG1819	glycosyl
MX663_11635	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
MX663_11640	COG0534	Mate efflux family protein
MX663_11645	COG1366	Belongs to the anti-sigma-factor antagonist family
MX663_11650	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MX663_11655	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MX663_11665	COG2962	Rard protein
MX663_11680	COG2610	gluconate transmembrane transporter activity
MX663_11685	COG1942	4-Oxalocrotonate Tautomerase
MX663_11690	COG1733	regulation of RNA biosynthetic process
MX663_11695	COG0778	Nitroreductase
MX663_11700	COG0400	carboxylic ester hydrolase activity
MX663_11705	COG0346	lactoylglutathione lyase activity
MX663_11715	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MX663_11720	COG3409	Peptidoglycan-binding domain 1 protein
MX663_11720	COG0793	Belongs to the peptidase S41A family
MX663_11725	COG2226	methyltransferase
MX663_11735	COG1876	peptidase activity
MX663_11740	COG0813	purine-nucleoside phosphorylase activity
MX663_11755	COG0671	phosphoesterase, PA-phosphatase related
MX663_11775	COG4479	Belongs to the UPF0346 family
MX663_11785	COG1509	lysine 2,3-aminomutase activity
MX663_11790	COG0456	acetyltransferase
MX663_11795	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MX663_11800	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MX663_11805	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MX663_11810	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MX663_11825	COG0456	acetyltransferase
MX663_11830	COG0463	Glycosyl transferase, family 2
MX663_11845	COG4641	Protein conserved in bacteria
MX663_11850	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
MX663_11855	COG1086	Polysaccharide biosynthesis protein
MX663_11860	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MX663_11865	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
MX663_11870	COG1846	Transcriptional regulator
MX663_11875	COG0534	Mate efflux family protein
MX663_11885	COG4698	Protein conserved in bacteria
MX663_11890	COG2755	lipolytic protein G-D-S-L family
MX663_11895	COG1999	signal sequence binding
MX663_11905	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
MX663_11910	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
MX663_11915	COG1272	protein, Hemolysin III
MX663_11920	COG0204	Acyl-transferase
MX663_11925	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MX663_11930	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
MX663_11935	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MX663_11945	COG2521	methyltransferase
MX663_11945	COG2136	Putative SAM-dependent methyltransferase
MX663_11955	COG0129	dihydroxy-acid dehydratase activity
MX663_11960	COG1413	lyase activity
MX663_11965	COG1418	mRNA catabolic process
MX663_11970	COG0386	Belongs to the glutathione peroxidase family
MX663_11975	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
MX663_11980	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
MX663_11990	COG1278	Cold shock
MX663_12010	COG0328	RNA-DNA hybrid ribonuclease activity
MX663_12015	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
MX663_12020	COG0328	RNA-DNA hybrid ribonuclease activity
MX663_12030	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MX663_12045	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MX663_12055	COG1755	Isoprenylcysteine carboxyl methyltransferase
MX663_12060	COG3424	synthase
MX663_12065	COG2233	PERMEase
MX663_12070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MX663_12075	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
MX663_12085	COG0800	Aldolase
MX663_12090	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MX663_12095	COG1609	Transcriptional regulator
MX663_12100	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
MX663_12105	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_12110	COG1199	ATP-dependent helicase activity
MX663_12125	COG0116	Belongs to the methyltransferase superfamily
MX663_12140	COG4474	Belongs to the UPF0398 family
MX663_12155	COG3359	exonuclease
MX663_12160	COG1111	helicase
MX663_12160	COG1205	dead DEAH box helicase
MX663_12165	COG2190	(PTS) system
MX663_12170	COG0071	Belongs to the small heat shock protein (HSP20) family
MX663_12205	COG3331	DNA recombination
MX663_12210	COG4499	WXG100 protein secretion system (Wss), protein YukC
MX663_12210	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MX663_12220	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
MX663_12225	COG3935	DnaD domain protein
MX663_12230	COG0017	Asparaginyl-tRNA synthetase
MX663_12235	COG0436	Aminotransferase
MX663_12240	COG5353	protein conserved in bacteria
MX663_12250	COG1199	ATP-dependent helicase activity
MX663_12250	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
MX663_12255	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
MX663_12260	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
MX663_12265	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
MX663_12270	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
MX663_12270	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
MX663_12275	COG0617	tRNA 3'-terminal CCA addition
MX663_12280	COG0438	transferase activity, transferring glycosyl groups
MX663_12285	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
MX663_12290	COG1803	Methylglyoxal synthase
MX663_12295	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
MX663_12300	COG1694	Mazg nucleotide pyrophosphohydrolase
MX663_12305	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MX663_12315	COG4347	Protein of unknown function (DUF1405)
MX663_12320	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MX663_12320	COG2010	Cytochrome c
MX663_12325	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
MX663_12330	COG0723	plastoquinol--plastocyanin reductase activity
MX663_12340	COG5582	Belongs to the UPF0302 family
MX663_12345	COG0457	Tetratricopeptide repeat
MX663_12350	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
MX663_12355	COG0287	Prephenate dehydrogenase
MX663_12360	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
MX663_12365	COG0159	tryptophan synthase activity
MX663_12370	COG0133	tryptophan synthase activity
MX663_12375	COG0135	phosphoribosylanthranilate isomerase activity
MX663_12385	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
MX663_12390	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
MX663_12395	COG4401	Chorismate mutase type I
MX663_12400	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
MX663_12405	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
MX663_12410	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
MX663_12415	COG0105	UTP biosynthetic process
MX663_12420	COG0142	geranyltranstransferase activity
MX663_12425	COG2226	methyltransferase
MX663_12430	COG0142	geranyltranstransferase activity
MX663_12440	COG0302	gtp cyclohydrolase
MX663_12445	COG0776	regulation of translation
MX663_12450	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
MX663_12465	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
MX663_12470	COG1160	GTP binding
MX663_12495	COG1304	FMN binding
MX663_12500	COG0539	negative regulation of cytoplasmic translation
MX663_12505	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
MX663_12515	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
MX663_12520	COG2959	enzyme of heme biosynthesis
MX663_12525	COG3773	Cell wall hydrolase
MX663_12525	COG3409	Peptidoglycan-binding domain 1 protein
MX663_12530	COG2339	peptidase activity
MX663_12535	COG0492	ferredoxin-NADP+ reductase activity
MX663_12540	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MX663_12545	COG4862	establishment of competence for transformation
MX663_12550	COG1408	metallophosphoesterase
MX663_12560	COG1388	LysM domain
MX663_12565	COG1266	CAAX protease self-immunity
MX663_12570	COG0514	ATP-dependent DNA helicase (RecQ)
MX663_12575	COG4955	Helix-turn-helix domain
MX663_12580	COG1141	Ferredoxin
MX663_12585	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
MX663_12590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
MX663_12595	COG0710	3-dehydroquinate dehydratase activity
MX663_12605	COG1595	DNA-templated transcription, initiation
MX663_12610	COG5002	protein histidine kinase activity
MX663_12615	COG0745	RESPONSE REGULATOR receiver
MX663_12620	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MX663_12625	COG1333	cytochrome c biogenesis protein
MX663_12630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MX663_12635	COG1187	pseudouridine synthase activity
MX663_12640	COG0700	Nucleoside recognition
MX663_12645	COG2715	membrane protein required for spore maturation
MX663_12650	COG1686	Belongs to the peptidase S11 family
MX663_12660	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
MX663_12665	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
MX663_12670	COG1547	Domain of unknown function (DUF309)
MX663_12675	COG0456	acetyltransferase
MX663_12680	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
MX663_12685	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MX663_12685	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
MX663_12690	COG0307	riboflavin synthase, alpha
MX663_12695	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MX663_12695	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
MX663_12705	COG0681	Belongs to the peptidase S26 family
MX663_12715	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
MX663_12755	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
MX663_12760	COG4086	secreted protein
MX663_12765	COG0019	diaminopimelate decarboxylase activity
MX663_12770	COG0697	spore germination
MX663_12785	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
MX663_12805	COG1191	sigma factor activity
MX663_12810	COG2172	sigma factor antagonist activity
MX663_12815	COG1366	Belongs to the anti-sigma-factor antagonist family
MX663_12820	COG1686	Belongs to the peptidase S11 family
MX663_12825	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
MX663_12830	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
MX663_12835	COG4974	Belongs to the 'phage' integrase family
MX663_12845	COG0735	belongs to the Fur family
MX663_12850	COG1300	Membrane
MX663_12860	COG0281	malic enzyme
MX663_12865	COG1757	Na H antiporter
MX663_12870	COG1027	Aspartate ammonia-lyase
MX663_12875	COG0252	asparaginase activity
MX663_12880	COG1396	sequence-specific DNA binding
MX663_12885	COG1379	DNA repair
MX663_12890	COG0494	nUDIX hydrolase
MX663_12900	COG0667	Aldo Keto reductase
MX663_12910	COG1073	alpha beta
MX663_12920	COG4918	Iron-sulphur cluster biosynthesis
MX663_12925	COG0456	acetyltransferase
MX663_12925	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
MX663_12930	COG2329	Antibiotic biosynthesis monooxygenase
MX663_12935	COG0456	acetyltransferase
MX663_12945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MX663_12955	COG2211	Major facilitator Superfamily
MX663_12965	COG0346	lactoylglutathione lyase activity
MX663_12970	COG1072	(Pantothenic acid kinase))
MX663_12975	COG3048	D-serine ammonia-lyase activity
MX663_12980	COG0300	oxidoreductase activity
MX663_12985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MX663_12990	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MX663_12995	COG4187	Peptidase family M20/M25/M40
MX663_13000	COG1902	pentaerythritol trinitrate reductase activity
MX663_13005	COG0596	Alpha beta hydrolase
MX663_13015	COG1234	tRNA 3'-trailer cleavage
MX663_13020	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
MX663_13025	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MX663_13030	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
MX663_13040	COG0706	membrane insertase activity
MX663_13050	COG2195	Cleaves the N-terminal amino acid of tripeptides
MX663_13055	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
MX663_13060	COG0346	lactoylglutathione lyase activity
MX663_13070	COG1376	ErfK ybiS ycfS ynhG family protein
MX663_13075	COG4129	membrane
MX663_13080	COG1126	abc transporter atp-binding protein
MX663_13085	COG0765	amino acid transport
MX663_13090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MX663_13100	COG1597	lipid kinase activity
MX663_13105	COG2814	Major facilitator Superfamily
MX663_13110	COG0789	Transcriptional regulator
MX663_13110	COG4978	Transcriptional regulator
MX663_13115	COG0508	dehydrogenase complex catalyzes the overall conversion of
MX663_13120	COG0022	dehydrogenase e1 component
MX663_13125	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
MX663_13130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
MX663_13135	COG3426	butyrate kinase activity
MX663_13140	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MX663_13145	COG0280	phosphate acetyltransferase
MX663_13150	COG3829	transcription factor binding
MX663_13150	COG3290	protein histidine kinase activity
MX663_13160	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
MX663_13165	COG2079	MmgE PrpD family protein
MX663_13170	COG0372	Belongs to the citrate synthase family
MX663_13175	COG1960	acyl-CoA dehydrogenase activity
MX663_13180	COG1250	3-hydroxyacyl-CoA dehydrogenase
MX663_13185	COG0183	Belongs to the thiolase family
MX663_13190	COG0584	glycerophosphoryl diester phosphodiesterase
MX663_13195	COG0860	N-Acetylmuramoyl-L-alanine amidase
MX663_13210	COG1902	pentaerythritol trinitrate reductase activity
MX663_13215	COG0745	RESPONSE REGULATOR receiver
MX663_13220	COG0750	zinc metalloprotease
MX663_13225	COG0497	DNA recombination
MX663_13230	COG1438	arginine binding
MX663_13235	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
MX663_13240	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
MX663_13245	COG0142	geranyltranstransferase activity
MX663_13250	COG1722	exodeoxyribonuclease VII activity
MX663_13255	COG1570	exodeoxyribonuclease VII activity
MX663_13260	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
MX663_13265	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
MX663_13270	COG1302	Protein conserved in bacteria
MX663_13275	COG0439	Biotin carboxylase
MX663_13280	COG0511	ligase activity, forming carbon-carbon bonds
MX663_13320	COG3854	ATPases associated with a variety of cellular activities
MX663_13330	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
MX663_13335	COG0006	proline dipeptidase activity
MX663_13340	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
MX663_13350	COG3872	metal-dependent enzyme
MX663_13360	COG1752	Esterase of the alpha-beta hydrolase superfamily
MX663_13365	COG1321	iron dependent repressor
MX663_13370	COG0095	Lipoate-protein ligase
MX663_13375	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MX663_13380	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MX663_13385	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
MX663_13390	COG0404	The glycine cleavage system catalyzes the degradation of glycine
MX663_13395	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MX663_13410	COG1396	sequence-specific DNA binding
MX663_13420	COG0681	Belongs to the peptidase S26 family
MX663_13445	COG4940	Competence protein ComGF
MX663_13455	COG4970	Tfp pilus assembly protein FimT
MX663_13460	COG4537	Required for transformation and DNA binding
MX663_13465	COG1459	type II secretion system
MX663_13470	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
MX663_13475	COG0598	Magnesium transport protein CorA
MX663_13480	COG1253	flavin adenine dinucleotide binding
MX663_13485	COG1366	Belongs to the anti-sigma-factor antagonist family
MX663_13495	COG1393	Belongs to the ArsC family
MX663_13505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MX663_13515	COG0011	TIGRFAM Protein of
MX663_13525	COG2866	Carboxypeptidase
MX663_13530	COG1368	sulfuric ester hydrolase activity
MX663_13535	COG1940	carbohydrate kinase activity
MX663_13540	COG4483	Protein conserved in bacteria
MX663_13545	COG0705	Rhomboid family
MX663_13545	COG0457	Tetratricopeptide repeat
MX663_13555	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
MX663_13565	COG0438	transferase activity, transferring glycosyl groups
MX663_13580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MX663_13585	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MX663_13590	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
MX663_13595	COG0581	inorganic phosphate transmembrane transporter activity
MX663_13600	COG0573	inorganic phosphate transmembrane transporter activity
MX663_13605	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
MX663_13610	COG0768	penicillin binding
MX663_13615	COG0477	Major facilitator Superfamily
MX663_13620	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
MX663_13625	COG2839	Protein conserved in bacteria
MX663_13630	COG5521	maltodextrose utilization protein MalA
MX663_13635	COG1388	LysM domain
MX663_13640	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
MX663_13645	COG4709	membrane
MX663_13650	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
MX663_13655	COG0735	belongs to the Fur family
MX663_13660	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MX663_13670	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
MX663_13675	COG0513	Belongs to the DEAD box helicase family
MX663_13685	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
MX663_13690	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
MX663_13695	COG2384	SAM-dependent methyltransferase
MX663_13700	COG2010	Cytochrome c
MX663_13705	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
MX663_13710	COG0358	DNA primase activity
MX663_13715	COG1671	Belongs to the UPF0178 family
MX663_13720	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
MX663_13725	COG0517	IMP dehydrogenase activity
MX663_13730	COG0751	glycine-tRNA ligase activity
MX663_13735	COG0752	glycyl-tRNA synthetase alpha subunit
MX663_13740	COG1381	Involved in DNA repair and RecF pathway recombination
MX663_13750	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
MX663_13755	COG0295	cytidine deaminase activity
MX663_13760	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
MX663_13765	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
MX663_13770	COG1480	7TM receptor with intracellular HD hydrolase
MX663_13775	COG1702	phosphate starvation-inducible protein PhoH
MX663_13780	COG0561	phosphatase activity
MX663_13795	COG4864	UPF0365 protein
MX663_13800	COG1030	water channel activity
MX663_13805	COG1610	YqeY-like protein
MX663_13815	COG1283	sodium-dependent phosphate transmembrane transporter activity
MX663_13820	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
MX663_13825	COG1385	rRNA (uridine-N3-)-methyltransferase activity
MX663_13830	COG2264	protein methyltransferase activity
MX663_13835	COG0484	heat shock protein binding
MX663_13840	COG0443	Heat shock 70 kDa protein
MX663_13845	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
MX663_13850	COG1420	regulation of RNA biosynthetic process
MX663_13855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
MX663_13860	COG0481	GTPase activity
MX663_13870	COG0860	N-Acetylmuramoyl-L-alanine amidase
MX663_13875	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
MX663_13880	COG0268	Binds directly to 16S ribosomal RNA
MX663_13885	COG1466	dna polymerase III delta subunit
MX663_13900	COG2333	competence protein COMEC
MX663_13900	COG0658	competence protein
MX663_13905	COG2131	deaminase
MX663_13910	COG1596	polysaccharide export
MX663_13910	COG1555	photosystem II stabilization
MX663_13915	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
MX663_13920	COG2226	methyltransferase
MX663_13925	COG0799	negative regulation of ribosome biogenesis
MX663_13930	COG1713	HD superfamily hydrolase involved in NAD metabolism
MX663_13935	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
MX663_13940	COG1534	Rna-binding protein
MX663_13945	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
MX663_13950	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
MX663_13955	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
MX663_13965	COG2755	lipolytic protein G-D-S-L family
MX663_13970	COG5632	N-Acetylmuramoyl-L-alanine amidase
MX663_13970	COG3409	Peptidoglycan-binding domain 1 protein
MX663_13975	COG0398	Pfam SNARE associated Golgi protein
MX663_13980	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
MX663_13990	COG3209	COG3209 Rhs family protein
MX663_14000	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
MX663_14015	COG0604	alcohol dehydrogenase
MX663_14035	COG0300	oxidoreductase activity
MX663_14040	COG1902	pentaerythritol trinitrate reductase activity
MX663_14045	COG0596	Alpha beta hydrolase
MX663_14045	COG0508	dehydrogenase complex catalyzes the overall conversion of
MX663_14050	COG1309	transcriptional regulator
MX663_14060	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
MX663_14080	COG0457	Tetratricopeptide repeat
MX663_14090	COG5444	nuclease activity
MX663_14190	COG0563	adenylate kinase activity
MX663_14195	COG2856	Zn peptidase
MX663_14220	COG3223	Belongs to the PsiE family
MX663_14225	COG0642	Histidine kinase
MX663_14225	COG5002	protein histidine kinase activity
MX663_14230	COG0745	RESPONSE REGULATOR receiver
MX663_14235	COG2311	Membrane
MX663_14245	COG0454	-acetyltransferase
MX663_14250	COG2249	NAD(P)H dehydrogenase (quinone) activity
MX663_14260	COG0730	response to heat
MX663_14265	COG0425	Belongs to the sulfur carrier protein TusA family
MX663_14280	COG0425	Belongs to the sulfur carrier protein TusA family
MX663_14280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MX663_14290	COG2210	Belongs to the sulfur carrier protein TusA family
MX663_14295	COG1937	Protein conserved in bacteria
MX663_14305	COG0662	Cupin 2, conserved barrel domain protein
MX663_14320	COG0789	Transcriptional regulator
MX663_14320	COG4978	Transcriptional regulator
MX663_14325	COG2814	Major facilitator Superfamily
MX663_14330	COG0456	acetyltransferase
MX663_14335	COG1253	flavin adenine dinucleotide binding
MX663_14345	COG0697	spore germination
MX663_14350	COG0583	DNA-binding transcription factor activity
MX663_14355	COG2072	flavoprotein involved in K transport
MX663_14360	COG1230	cation diffusion facilitator family transporter
MX663_14365	COG1942	4-Oxalocrotonate Tautomerase
MX663_14370	COG0583	DNA-binding transcription factor activity
MX663_14385	COG1114	Component of the transport system for branched-chain amino acids
MX663_14390	COG1687	branched-chain amino acid
MX663_14395	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
MX663_14400	COG1522	sequence-specific DNA binding
MX663_14415	COG1335	isochorismatase
MX663_14435	COG2318	DinB family
MX663_14445	COG2070	2-Nitropropane dioxygenase
MX663_14450	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MX663_14470	COG3443	Belongs to the bacterial solute-binding protein 9 family
MX663_14475	COG1595	DNA-templated transcription, initiation
MX663_14480	COG0667	Aldo Keto reductase
MX663_14485	COG2851	Citrate transporter
MX663_14490	COG0583	DNA-binding transcription factor activity
MX663_14495	COG2828	Protein conserved in bacteria
MX663_14500	COG3409	Peptidoglycan-binding domain 1 protein
MX663_14505	COG5566	PFAM Mor transcription activator
MX663_14510	COG0596	Alpha beta hydrolase
MX663_14515	COG4991	sh3 domain protein
MX663_14520	COG4991	sh3 domain protein
MX663_14530	COG0346	lactoylglutathione lyase activity
MX663_14540	COG5577	PFAM Coat F domain
MX663_14545	COG1063	alcohol dehydrogenase
MX663_14555	COG5577	PFAM Coat F domain
MX663_14560	COG0789	Transcriptional regulator
MX663_14570	COG1064	alcohol dehydrogenase
MX663_14575	COG0693	protein deglycase activity
MX663_14580	COG1621	beta-fructofuranosidase activity
MX663_14590	COG3716	PTS system mannose fructose sorbose family IID component
MX663_14595	COG3715	PTS system
MX663_14600	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MX663_14605	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
MX663_14610	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
MX663_14610	COG3933	PFAM sigma-54 factor interaction domain-containing protein
MX663_14620	COG1113	amino acid transport
MX663_14625	COG1280	lysine exporter protein (LysE YggA)
MX663_14630	COG1378	Sugar-specific transcriptional regulator TrmB
MX663_14635	COG1595	DNA-templated transcription, initiation
MX663_14645	COG2755	lipolytic protein G-D-S-L family
MX663_14645	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
MX663_14655	COG2124	cytochrome p450
MX663_14655	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MX663_14660	COG1309	transcriptional regulator
MX663_14665	COG2226	methyltransferase
MX663_14680	COG2116	formate transmembrane transporter activity
MX663_14685	COG5609	conserved protein (DUF2294)
MX663_14695	COG2427	Protein of unknown function (DUF1641)
MX663_14705	COG0626	cystathionine gamma-synthase activity
MX663_14710	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MX663_14715	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
MX663_14720	COG2226	methyltransferase
MX663_14735	COG0768	penicillin binding
MX663_14740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
MX663_14745	COG0572	uridine kinase
MX663_14750	COG0826	peptidase U32
MX663_14755	COG0826	peptidase U32
MX663_14760	COG4122	O-methyltransferase activity
MX663_14765	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
MX663_14770	COG3906	Belongs to the UPF0473 family
MX663_14775	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
MX663_14780	COG4472	Bacterial protein of unknown function (DUF965)
MX663_14785	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
MX663_14790	COG0628	permease
MX663_14795	COG1126	abc transporter atp-binding protein
MX663_14800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MX663_14805	COG0765	amino acid transport
MX663_14810	COG0765	amino acid transport
MX663_14825	COG3881	PFAM PRC-barrel domain
MX663_14830	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
MX663_14835	COG0457	Tetratricopeptide repeat
MX663_14840	COG0482	sulfurtransferase activity
MX663_14845	COG1104	cysteine desulfurase activity
MX663_14850	COG1959	2 iron, 2 sulfur cluster binding
MX663_14855	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
MX663_14860	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
MX663_14870	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
MX663_14875	COG0124	histidyl-tRNA synthetase
MX663_14885	COG0860	N-Acetylmuramoyl-L-alanine amidase
MX663_14885	COG4991	sh3 domain protein
MX663_14885	COG3103	Sh3 type 3 domain protein
MX663_14890	COG1490	D-aminoacyl-tRNA deacylase activity
MX663_14895	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
MX663_14900	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
MX663_14905	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
MX663_14905	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
MX663_14910	COG5416	Lipopolysaccharide assembly protein A domain
MX663_14915	COG0490	domain, Protein
MX663_14920	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MX663_14920	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
MX663_14930	COG2244	polysaccharide biosynthetic process
MX663_14935	COG2323	membrane
MX663_14945	COG1862	Preprotein translocase
MX663_14950	COG0343	queuine tRNA-ribosyltransferase activity
MX663_14955	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
MX663_14965	COG2255	four-way junction helicase activity
MX663_14970	COG0632	four-way junction helicase activity
MX663_14980	COG2814	Major facilitator Superfamily
MX663_14985	COG0673	inositol 2-dehydrogenase activity
MX663_14990	COG2112	serine threonine protein kinase
MX663_15015	COG1115	amino acid carrier protein
MX663_15020	COG0217	transcriptional regulatory protein
MX663_15030	COG1388	LysM domain
MX663_15035	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
MX663_15040	COG0157	Belongs to the NadC ModD family
MX663_15045	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
MX663_15050	COG1104	cysteine desulfurase activity
MX663_15055	COG1827	regulation of RNA biosynthetic process
MX663_15060	COG0077	Prephenate dehydratase
MX663_15065	COG4492	Belongs to the UPF0735 family
MX663_15070	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
MX663_15075	COG3290	protein histidine kinase activity
MX663_15085	COG0211	Belongs to the bacterial ribosomal protein bL27 family
MX663_15090	COG2868	ribosomal protein
MX663_15095	COG0261	This protein binds to 23S rRNA in the presence of protein L20
MX663_15100	COG1994	Peptidase M50
MX663_15105	COG0739	heme binding
MX663_15110	COG2894	cell division
MX663_15115	COG0850	regulation of cytokinetic process
MX663_15120	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
MX663_15130	COG1077	Cell shape determining protein MreB Mrl
MX663_15135	COG2003	Belongs to the UPF0758 family
MX663_15140	COG0424	maF-like protein
MX663_15150	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
MX663_15155	COG0285	dihydrofolate synthase activity
MX663_15160	COG0525	valine-tRNA ligase activity
MX663_15170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MX663_15175	COG1388	LysM domain
MX663_15180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
MX663_15185	COG0113	porphobilinogen synthase activity
MX663_15190	COG1587	Uroporphyrinogen-III synthase
MX663_15195	COG0181	hydroxymethylbilane synthase activity
MX663_15200	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
MX663_15205	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
MX663_15215	COG0218	Necessary for normal cell division and for the maintenance of normal septation
MX663_15220	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
MX663_15225	COG1067	ATP-dependent peptidase activity
MX663_15225	COG0470	DNA polymerase III
MX663_15230	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
MX663_15235	COG0544	peptidyl-prolyl cis-trans isomerase activity
MX663_15240	COG0457	Tetratricopeptide repeat
MX663_15240	COG1477	protein flavinylation
MX663_15245	COG0066	3-isopropylmalate dehydratase activity
MX663_15250	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
MX663_15255	COG0473	3-isopropylmalate dehydrogenase activity
MX663_15260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
MX663_15265	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
MX663_15270	COG0440	acetolactate synthase activity
MX663_15275	COG0028	Belongs to the TPP enzyme family
MX663_15290	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
MX663_15300	COG0622	Phosphoesterase
MX663_15305	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
MX663_15310	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
MX663_15315	COG5401	PFAM Sporulation and spore germination
MX663_15320	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
MX663_15325	COG1846	Transcriptional regulator
MX663_15330	COG2197	response regulator
MX663_15335	COG0824	Thioesterase
MX663_15340	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
MX663_15345	COG1053	succinate dehydrogenase
MX663_15350	COG2009	succinate dehydrogenase
MX663_15355	COG1719	4-vinyl reductase, 4VR
MX663_15360	COG0527	aspartate kinase activity
MX663_15365	COG0322	excinuclease ABC activity
MX663_15370	COG3118	belongs to the thioredoxin family
MX663_15375	COG3534	alpha-L-arabinofuranosidase
MX663_15380	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
MX663_15385	COG2086	electron transfer activity
MX663_15390	COG1024	Enoyl-CoA hydratase
MX663_15395	COG1309	transcriptional regulator
MX663_15400	COG0318	PFAM AMP-dependent synthetase and ligase
MX663_15405	COG3766	membrane
MX663_15410	COG1193	negative regulation of DNA recombination
MX663_15415	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MX663_15415	COG1796	DNA polymerase
MX663_15420	COG1286	toxin biosynthetic process
MX663_15425	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
MX663_15430	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
MX663_15435	COG0072	phenylalanine-tRNA ligase activity
MX663_15435	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MX663_15440	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
MX663_15450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
MX663_15460	COG3835	regulator
MX663_15465	COG0277	FAD linked oxidase domain protein
MX663_15470	COG0247	lactate metabolic process
MX663_15475	COG0346	lactoylglutathione lyase activity
MX663_15485	COG1966	Carbon starvation protein
MX663_15490	COG3534	alpha-L-arabinofuranosidase
MX663_15495	COG0395	ABC-type sugar transport system, permease component
MX663_15500	COG1175	transmembrane transport
MX663_15505	COG1653	transport
MX663_15510	COG0371	Dehydrogenase
MX663_15515	COG0647	UMP catabolic process
MX663_15520	COG0235	Class ii aldolase
MX663_15525	COG1069	ribulokinase activity
MX663_15530	COG2160	L-arabinose isomerase activity
MX663_15535	COG3507	Belongs to the glycosyl hydrolase 43 family
MX663_15540	COG1363	Peptidase, m42
MX663_15550	COG3326	Membrane
MX663_15555	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
MX663_15560	COG0291	Belongs to the bacterial ribosomal protein bL35 family
MX663_15565	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
MX663_15575	COG1346	cytolysis
MX663_15580	COG1380	Effector of murein hydrolase LrgA
MX663_15585	COG3279	Response regulator of the LytR AlgR family
MX663_15590	COG3275	phosphorelay sensor kinase activity
MX663_15595	COG1011	Hydrolase
MX663_15600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MX663_15610	COG0398	Pfam SNARE associated Golgi protein
MX663_15615	COG1484	DNA-dependent DNA replication
MX663_15620	COG3611	Membrane attachment protein
MX663_15625	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
MX663_15630	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
MX663_15635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MX663_15640	COG1733	regulation of RNA biosynthetic process
MX663_15645	COG2814	Major facilitator Superfamily
MX663_15650	COG0656	L-ascorbic acid biosynthetic process
MX663_15655	COG0237	dephospho-CoA kinase activity
MX663_15660	COG1971	Probably functions as a manganese efflux pump
MX663_15665	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
MX663_15670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MX663_15670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
MX663_15675	COG5002	protein histidine kinase activity
MX663_15680	COG0745	RESPONSE REGULATOR receiver
MX663_15685	COG0039	L-malate dehydrogenase activity
MX663_15690	COG0538	isocitrate dehydrogenase activity
MX663_15695	COG0372	Belongs to the citrate synthase family
MX663_15700	COG2707	UPF0756 membrane protein
MX663_15705	COG0628	permease
MX663_15710	COG3030	protein affecting phage T7 exclusion by the F plasmid
MX663_15715	COG0469	pyruvate kinase activity
MX663_15720	COG0205	6-phosphofructokinase activity
MX663_15725	COG0825	malonyl-CoA metabolic process
MX663_15730	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
MX663_15735	COG0281	malic enzyme
MX663_15740	COG0587	DNA-directed DNA polymerase activity
MX663_15760	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
MX663_15770	COG4109	DRTGG domain
MX663_15775	COG0730	response to heat
MX663_15780	COG1473	amidohydrolase
MX663_15785	COG0196	riboflavin kinase activity
MX663_15790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MX663_15795	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
MX663_15800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MX663_15805	COG1126	abc transporter atp-binding protein
MX663_15810	COG0765	amino acid transport
MX663_15815	COG0765	amino acid transport
MX663_15820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MX663_15825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MX663_15830	COG0454	-acetyltransferase
MX663_15835	COG0583	DNA-binding transcription factor activity
MX663_15840	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
MX663_15845	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_15850	COG0165	Argininosuccinate lyase
MX663_15855	COG0137	argininosuccinate synthase activity
MX663_15860	COG0521	Mo-molybdopterin cofactor biosynthetic process
MX663_15865	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
MX663_15875	COG0827	DNA restriction-modification system
MX663_15880	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
MX663_15885	COG3874	Sporulation protein YtfJ
MX663_15895	COG1714	RDD family
MX663_15900	COG0616	signal peptide processing
MX663_15905	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
MX663_15910	COG1574	metal-dependent hydrolase with the TIM-barrel fold
MX663_15915	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MX663_15925	COG0301	tRNA thio-modification
MX663_15930	COG1104	cysteine desulfurase activity
MX663_15935	COG1114	Component of the transport system for branched-chain amino acids
MX663_15940	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
MX663_15945	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
MX663_15950	COG1309	transcriptional regulator
MX663_15955	COG1956	GAF domain-containing protein
MX663_15960	COG2203	Gaf domain
MX663_15960	COG2199	diguanylate cyclase activity
MX663_15965	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
MX663_15970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MX663_15975	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
MX663_15980	COG0454	-acetyltransferase
MX663_15985	COG0517	IMP dehydrogenase activity
MX663_15990	COG0123	including yeast histone deacetylase and acetoin utilization protein
MX663_15995	COG1360	Flagellar Motor Protein
MX663_16000	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
MX663_16005	COG1609	Transcriptional regulator
MX663_16010	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
MX663_16010	COG1605	Chorismate mutase
MX663_16015	COG3118	belongs to the thioredoxin family
MX663_16020	COG4980	gas vesicle protein
MX663_16025	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
MX663_16030	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
MX663_16035	COG1674	ftsk spoiiie
MX663_16040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
MX663_16045	COG4848	Belongs to the UPF0354 family
MX663_16050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MX663_16065	COG1363	Peptidase, m42
MX663_16070	COG5584	Small secreted protein
MX663_16075	COG0281	malic enzyme
MX663_16080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MX663_16085	COG0220	tRNA (guanine-N7-)-methyltransferase activity
MX663_16095	COG0510	thiamine kinase activity
MX663_16100	COG1523	belongs to the glycosyl hydrolase 13 family
MX663_16105	COG1597	lipid kinase activity
MX663_16115	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
MX663_16120	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
MX663_16125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MX663_16130	COG2252	PERMEase
MX663_16135	COG4473	ABC transporter
MX663_16140	COG1131	(ABC) transporter
MX663_16145	COG1349	DNA-binding transcription factor activity
MX663_16150	COG1187	pseudouridine synthase activity
MX663_16155	COG2244	polysaccharide biosynthetic process
MX663_16160	COG2081	HI0933 family
MX663_16165	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
MX663_16175	COG5578	integral membrane protein
MX663_16180	COG0673	inositol 2-dehydrogenase activity
MX663_16185	COG1653	transport
MX663_16190	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
MX663_16195	COG4209	transmembrane transport
MX663_16200	COG2207	Transcriptional regulator
MX663_16205	COG1653	transport
MX663_16210	COG0395	ABC-type sugar transport system, permease component
MX663_16215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MX663_16220	COG2124	cytochrome p450
MX663_16225	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
MX663_16235	COG0156	8-amino-7-oxononanoate synthase activity
MX663_16240	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
MX663_16245	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
MX663_16250	COG1073	alpha beta
MX663_16255	COG1609	Transcriptional regulator
MX663_16260	COG1653	transport
MX663_16265	COG1175	transmembrane transport
MX663_16270	COG0395	ABC-type sugar transport system, permease component
MX663_16275	COG1486	melibiose metabolic process
MX663_16280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
MX663_16285	COG0495	leucyl-tRNA aminoacylation
MX663_16295	COG2202	Pas domain
MX663_16295	COG1366	Belongs to the anti-sigma-factor antagonist family
MX663_16300	COG2814	Major facilitator Superfamily
MX663_16305	COG2433	Pfam Transposase IS66
MX663_16310	COG0577	efflux transmembrane transporter activity
MX663_16315	COG1136	(ABC) transporter
MX663_16320	COG2205	protein histidine kinase activity
MX663_16325	COG0745	RESPONSE REGULATOR receiver
MX663_16330	COG0577	efflux transmembrane transporter activity
MX663_16335	COG1136	(ABC) transporter
MX663_16350	COG1131	(ABC) transporter
MX663_16355	COG1725	Transcriptional regulator
MX663_16370	COG1242	4 iron, 4 sulfur cluster binding
MX663_16375	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
MX663_16385	COG2267	carboxylic ester hydrolase activity
MX663_16390	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
MX663_16395	COG1113	amino acid transport
MX663_16400	COG0367	asparagine synthase
MX663_16405	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
MX663_16410	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
MX663_16420	COG1506	peptidase
MX663_16425	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
MX663_16430	COG1116	anion transmembrane transporter activity
MX663_16435	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
MX663_16440	COG0494	nUDIX hydrolase
MX663_16445	COG4824	toxin secretion phage lysis holin
MX663_16450	COG0783	Belongs to the Dps family
MX663_16465	COG1854	S-ribosylhomocysteine lyase activity
MX663_16470	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
MX663_16475	COG0288	reversible hydration of carbon dioxide
MX663_16480	COG0254	rRNA binding
MX663_16485	COG1271	oxidase subunit
MX663_16490	COG1294	oxidase, subunit
MX663_16500	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MX663_16505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
MX663_16505	COG1321	iron dependent repressor
MX663_16510	COG1121	(ABC) transporter
MX663_16515	COG0803	Belongs to the bacterial solute-binding protein 9 family
MX663_16520	COG4948	Mandelate Racemase Muconate Lactonizing
MX663_16525	COG0318	PFAM AMP-dependent synthetase and ligase
MX663_16530	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
MX663_16535	COG0596	Alpha beta hydrolase
MX663_16540	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
MX663_16545	COG1169	isochorismate synthase
MX663_16550	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
MX663_16555	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MX663_16560	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MX663_16565	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
MX663_16570	COG0438	transferase activity, transferring glycosyl groups
MX663_16580	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MX663_16585	COG0438	transferase activity, transferring glycosyl groups
MX663_16590	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MX663_16595	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
MX663_16600	COG0058	SHG alpha-glucan phosphorylase activity
MX663_16605	COG0297	glycogen (starch) synthase activity
MX663_16610	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MX663_16615	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
MX663_16620	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
MX663_16745	COG3859	Proton-coupled thiamine transporter YuaJ
MX663_16750	COG1247	-acetyltransferase
MX663_16755	COG2268	Band 7 protein
MX663_16760	COG1585	Membrane protein implicated in regulation of membrane protease activity
MX663_16765	COG2318	DinB family
MX663_16775	COG1454	alcohol dehydrogenase
MX663_16780	COG1012	belongs to the aldehyde dehydrogenase family
MX663_16785	COG1510	regulation of RNA biosynthetic process
MX663_16795	COG0569	domain protein
MX663_16800	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
MX663_16805	COG4682	membrane
MX663_16810	COG1705	Flagellar rod assembly protein muramidase FlgJ
MX663_16815	COG0477	Major facilitator Superfamily
MX663_16820	COG5553	Cysteine dioxygenase type I
MX663_16830	COG1968	undecaprenyl-diphosphatase activity
MX663_16835	COG0628	permease
MX663_16840	COG0673	inositol 2-dehydrogenase activity
MX663_16845	COG4806	L-rhamnose isomerase
MX663_16850	COG3254	rhamnose metabolic process
MX663_16855	COG1070	Carbohydrate kinase
MX663_16860	COG1349	DNA-binding transcription factor activity
MX663_16865	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_16865	COG3347	Dehydrogenase
MX663_16870	COG0840	transmembrane signaling receptor activity
MX663_16875	COG0840	transmembrane signaling receptor activity
MX663_16880	COG0840	transmembrane signaling receptor activity
MX663_16885	COG0840	transmembrane signaling receptor activity
MX663_16900	COG0432	Pfam Uncharacterised protein family UPF0047
MX663_16910	COG0366	Alpha amylase catalytic
MX663_16915	COG1253	flavin adenine dinucleotide binding
MX663_16920	COG2738	Putative neutral zinc metallopeptidase
MX663_16935	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
MX663_16950	COG0166	Belongs to the GPI family
MX663_16955	COG1979	alcohol dehydrogenase
MX663_16960	COG1979	alcohol dehydrogenase
MX663_16965	COG2155	Conserved Protein
MX663_16970	COG1098	S1 RNA binding domain
MX663_16975	COG0436	Aminotransferase
MX663_16980	COG1522	sequence-specific DNA binding
MX663_16985	COG2267	carboxylic ester hydrolase activity
MX663_16995	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
MX663_17000	COG2205	protein histidine kinase activity
MX663_17010	COG5018	Exonuclease
MX663_17020	COG2814	Major facilitator Superfamily
MX663_17025	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MX663_17030	COG3011	Protein conserved in bacteria
MX663_17040	COG3290	protein histidine kinase activity
MX663_17045	COG4565	transcriptional regulatory protein
MX663_17050	COG1744	ABC transporter substrate-binding protein PnrA-like
MX663_17055	COG3845	ABC transporter
MX663_17060	COG4603	Belongs to the binding-protein-dependent transport system permease family
MX663_17065	COG1079	Belongs to the binding-protein-dependent transport system permease family
MX663_17070	COG3493	citrate carrier protein
MX663_17080	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
MX663_17080	COG2111	Na H antiporter
MX663_17085	COG2111	Na H antiporter
MX663_17090	COG1006	Multisubunit Na H antiporter MnhC subunit
MX663_17095	COG0651	ATP synthesis coupled electron transport
MX663_17100	COG1863	multisubunit Na H antiporter MnhE subunit
MX663_17105	COG2212	antiporter activity
MX663_17110	COG1320	monovalent cation:proton antiporter activity
MX663_17115	COG2050	protein possibly involved in aromatic compounds catabolism
MX663_17120	COG2197	response regulator
MX663_17125	COG4585	Histidine kinase
MX663_17135	COG0142	geranyltranstransferase activity
MX663_17155	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
MX663_17160	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
MX663_17165	COG1335	isochorismatase
MX663_17170	COG5506	Protein of unknown function (DUF1694)
MX663_17185	COG0628	permease
MX663_17200	COG1418	mRNA catabolic process
MX663_17205	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_17215	COG1511	domain protein
MX663_17220	COG1674	ftsk spoiiie
MX663_17220	COG0433	COG0433 Predicted ATPase
MX663_17225	COG4499	WXG100 protein secretion system (Wss), protein YukC
MX663_17230	COG5417	Belongs to the EsaB family
MX663_17235	COG4842	Belongs to the WXG100 family
MX663_17240	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
MX663_17240	COG2508	Transcriptional regulator
MX663_17245	COG0686	Belongs to the AlaDH PNT family
MX663_17250	COG5634	Uncharacterized conserved protein (DUF2278)
MX663_17255	COG3251	PFAM MbtH domain protein
MX663_17260	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MX663_17265	COG3433	isochorismatase activity
MX663_17265	COG1535	isochorismatase
MX663_17270	COG1021	2,3-dihydroxybenzoate-AMP ligase
MX663_17275	COG1169	isochorismate synthase
MX663_17280	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_17285	COG2819	hydrolase of the alpha beta superfamily
MX663_17290	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
MX663_17295	COG1268	BioY protein
MX663_17300	COG2056	Na+-H+ antiporter family
MX663_17305	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
MX663_17310	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
MX663_17315	COG3584	3D domain protein
MX663_17330	COG1252	NADH dehydrogenase
MX663_17335	COG0492	ferredoxin-NADP+ reductase activity
MX663_17345	COG0516	GMP reductase activity
MX663_17355	COG2808	Putative FMN-binding domain
MX663_17360	COG0456	acetyltransferase
MX663_17365	COG0316	Belongs to the HesB IscA family
MX663_17370	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
MX663_17375	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MX663_17380	COG4844	belongs to the
MX663_17385	COG1252	NADH dehydrogenase
MX663_17390	COG4837	Protein of unknown function (DUF1462)
MX663_17395	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
MX663_17400	COG4946	Tricorn protease homolog
MX663_17400	COG1506	peptidase
MX663_17400	COG0823	Involved in the tonB-independent uptake of proteins
MX663_17405	COG0083	homoserine kinase activity
MX663_17410	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
MX663_17415	COG0460	homoserine dehydrogenase
MX663_17420	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
MX663_17425	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
MX663_17430	COG0647	UMP catabolic process
MX663_17435	COG2445	Protein of unknown function DUF86
MX663_17440	COG4470	Protein conserved in bacteria
MX663_17450	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
MX663_17455	COG0739	heme binding
MX663_17465	COG3377	Domain of unknown function (DUF1805)
MX663_17470	COG0737	Belongs to the 5'-nucleotidase family
MX663_17475	COG0730	response to heat
MX663_17480	COG1801	Protein of unknown function DUF72
MX663_17490	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
MX663_17495	COG2508	Transcriptional regulator
MX663_17500	COG2233	PERMEase
MX663_17505	COG2233	PERMEase
MX663_17510	COG3195	allantoin biosynthetic process
MX663_17510	COG3648	Uricase
MX663_17515	COG2351	hydroxyisourate hydrolase activity
MX663_17525	COG2080	2 iron, 2 sulfur cluster binding
MX663_17530	COG1529	Aldehyde oxidase and xanthine dehydrogenase
MX663_17535	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
MX663_17540	COG2068	MobA-Related Protein
MX663_17545	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
MX663_17550	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
MX663_17555	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
MX663_17565	COG2356	endonuclease I
MX663_17570	COG3842	ATPase activity
MX663_17575	COG2188	Transcriptional regulator
MX663_17580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MX663_17585	COG0395	ABC-type sugar transport system, permease component
MX663_17590	COG1175	transmembrane transport
MX663_17595	COG1653	transport
MX663_17600	COG2222	sugar isomerase
MX663_17605	COG0322	excinuclease ABC activity
MX663_17610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
MX663_17625	COG0346	lactoylglutathione lyase activity
MX663_17630	COG0640	Transcriptional regulator
MX663_17635	COG0719	Fe-S assembly protein
MX663_17640	COG0822	iron-sulfur transferase activity
MX663_17645	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
MX663_17650	COG0719	Fe-S assembly protein
MX663_17655	COG0396	ATPase activity
MX663_17665	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
MX663_17670	COG1464	Belongs to the NlpA lipoprotein family
MX663_17675	COG2011	ABC-type metal ion transport system permease component
MX663_17680	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
MX663_17690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
MX663_17695	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
MX663_17705	COG0509	glycine decarboxylation via glycine cleavage system
MX663_17710	COG1393	Belongs to the ArsC family
MX663_17715	COG1960	acyl-CoA dehydrogenase activity
MX663_17720	COG0183	Belongs to the thiolase family
MX663_17725	COG1024	Enoyl-CoA hydratase
MX663_17725	COG1250	3-hydroxyacyl-CoA dehydrogenase
MX663_17735	COG0506	proline dehydrogenase activity
MX663_17745	COG5577	PFAM Coat F domain
MX663_17750	COG1846	Transcriptional regulator
MX663_17755	COG0477	Major facilitator Superfamily
MX663_17760	COG1942	4-Oxalocrotonate Tautomerase
MX663_17765	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_17770	COG0583	DNA-binding transcription factor activity
MX663_17780	COG1120	ATPase activity
MX663_17795	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_17800	COG0783	Belongs to the Dps family
MX663_17805	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MX663_17810	COG0745	RESPONSE REGULATOR receiver
MX663_17815	COG2770	Histidine kinase
MX663_17815	COG2205	protein histidine kinase activity
MX663_17825	COG1309	transcriptional regulator
MX663_17830	COG0114	fumarate hydratase activity
MX663_17840	COG0697	spore germination
MX663_17845	COG0814	amino acid
MX663_17855	COG2197	response regulator
MX663_17860	COG4585	Histidine kinase
MX663_17865	COG4758	membrane
MX663_17870	COG3595	metallopeptidase activity
MX663_17875	COG1842	Phage shock protein A
MX663_17880	COG4758	membrane
MX663_17885	COG2814	Major facilitator Superfamily
MX663_17890	COG2096	Adenosyltransferase
MX663_17895	COG1120	ATPase activity
MX663_17900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MX663_17905	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MX663_17910	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_17915	COG3386	PFAM SMP-30 Gluconolaconase
MX663_17920	COG2205	protein histidine kinase activity
MX663_17925	COG0745	RESPONSE REGULATOR receiver
MX663_17935	COG1191	sigma factor activity
MX663_17945	COG2140	Oxalate decarboxylase
MX663_17955	COG0577	efflux transmembrane transporter activity
MX663_17960	COG1136	(ABC) transporter
MX663_17965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
MX663_17970	COG1120	ATPase activity
MX663_17975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MX663_17980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
MX663_17990	COG0531	amino acid
MX663_18000	COG1988	membrane-bound metal-dependent
MX663_18005	COG1368	sulfuric ester hydrolase activity
MX663_18010	COG1910	domain protein
MX663_18015	COG0725	ABC transporter, periplasmic molybdate-binding protein
MX663_18020	COG4149	molybdate abc transporter
MX663_18025	COG0656	L-ascorbic acid biosynthetic process
MX663_18035	COG0025	NhaP-type Na H and K H
MX663_18040	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
MX663_18045	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
MX663_18050	COG3973	AAA domain
MX663_18060	COG2860	membrane
MX663_18065	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
MX663_18070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
MX663_18075	COG2217	Heavy metal translocating P-type atpase
MX663_18080	COG2217	Heavy metal translocating P-type atpase
MX663_18085	COG2608	mercury ion transmembrane transporter activity
MX663_18090	COG1937	Protein conserved in bacteria
MX663_18095	COG0673	inositol 2-dehydrogenase activity
MX663_18100	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
MX663_18115	COG2076	Multidrug Resistance protein
MX663_18120	COG1309	transcriptional regulator
MX663_18125	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_18135	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
MX663_18140	COG0557	exoribonuclease II activity
MX663_18145	COG1647	Serine aminopeptidase, S33
MX663_18150	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
MX663_18155	COG0596	Alpha beta hydrolase
MX663_18160	COG1476	TRANSCRIPTIONal
MX663_18165	COG1396	sequence-specific DNA binding
MX663_18170	COG1396	sequence-specific DNA binding
MX663_18175	COG1733	regulation of RNA biosynthetic process
MX663_18180	COG0840	transmembrane signaling receptor activity
MX663_18185	COG1174	glycine betaine transport
MX663_18190	COG1732	Glycine betaine
MX663_18195	COG1174	glycine betaine transport
MX663_18200	COG0517	IMP dehydrogenase activity
MX663_18200	COG1125	glycine betaine transport
MX663_18205	COG1510	regulation of RNA biosynthetic process
MX663_18210	COG1174	glycine betaine transport
MX663_18215	COG1732	Glycine betaine
MX663_18220	COG1174	glycine betaine transport
MX663_18225	COG0517	IMP dehydrogenase activity
MX663_18225	COG1125	glycine betaine transport
MX663_18230	COG1510	regulation of RNA biosynthetic process
MX663_18235	COG2095	MarC family integral membrane protein
MX663_18245	COG3064	Membrane
MX663_18250	COG4640	response to antibiotic
MX663_18255	COG0456	acetyltransferase
MX663_18260	COG0148	phosphopyruvate hydratase activity
MX663_18265	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
MX663_18270	COG0149	triose-phosphate isomerase activity
MX663_18275	COG0126	phosphoglycerate kinase activity
MX663_18280	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
MX663_18285	COG2390	Transcriptional regulator
MX663_18290	COG2814	Major facilitator Superfamily
MX663_18295	COG1609	Transcriptional regulator
MX663_18300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MX663_18305	COG0583	DNA-binding transcription factor activity
MX663_18310	COG0697	spore germination
MX663_18315	COG1113	amino acid transport
MX663_18320	COG3858	chitin binding
MX663_18325	COG1556	Lactate utilization protein
MX663_18330	COG1139	Iron-sulfur cluster binding protein
MX663_18335	COG0247	lactate metabolic process
MX663_18340	COG2197	response regulator
MX663_18345	COG4585	Histidine kinase
MX663_18350	COG0842	Transport permease protein
MX663_18355	COG1131	(ABC) transporter
MX663_18360	COG0596	Alpha beta hydrolase
MX663_18365	COG2208	phosphoserine phosphatase activity
MX663_18370	COG3867	Arabinogalactan endo-beta-1,4-galactanase
MX663_18375	COG1874	Beta-galactosidase
MX663_18380	COG3833	ABC-type maltose transport systems, permease component
MX663_18385	COG1175	transmembrane transport
MX663_18390	COG2182	Extracellular solute-binding protein
MX663_18395	COG1609	Transcriptional regulator
MX663_18400	COG2186	Transcriptional regulator
MX663_18405	COG1620	l-lactate permease
MX663_18410	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
MX663_18420	COG5039	Polysaccharide pyruvyl transferase
MX663_18425	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MX663_18430	COG0110	maltose O-acetyltransferase activity
MX663_18435	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
MX663_18440	COG2244	polysaccharide biosynthetic process
MX663_18445	COG1216	Glycosyl transferase, family 2
MX663_18450	COG5039	Polysaccharide pyruvyl transferase
MX663_18455	COG1216	Glycosyl transferase, family 2
MX663_18465	COG0438	transferase activity, transferring glycosyl groups
MX663_18470	COG1215	transferase activity, transferring glycosyl groups
MX663_18475	COG0438	transferase activity, transferring glycosyl groups
MX663_18480	COG1086	Polysaccharide biosynthesis protein
MX663_18485	COG0489	protein tyrosine kinase activity
MX663_18490	COG3944	biosynthesis protein
MX663_18495	COG1396	sequence-specific DNA binding
MX663_18500	COG2272	Belongs to the type-B carboxylesterase lipase family
MX663_18510	COG3479	Phenolic acid decarboxylase
MX663_18520	COG1794	racemase activity, acting on amino acids and derivatives
MX663_18525	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
MX663_18530	COG1621	beta-fructofuranosidase activity
MX663_18535	COG1621	beta-fructofuranosidase activity
MX663_18540	COG0531	amino acid
MX663_18545	COG1309	transcriptional regulator
MX663_18550	COG2076	Multidrug Resistance protein
MX663_18555	COG2076	Multidrug Resistance protein
MX663_18565	COG0277	FAD linked oxidase domain protein
MX663_18570	COG3621	Patatin-like phospholipase
MX663_18580	COG0740	serine-type endopeptidase activity
MX663_18585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
MX663_18590	COG0366	Alpha amylase catalytic
MX663_18595	COG1554	hydrolase, family 65, central catalytic
MX663_18600	COG5521	maltodextrose utilization protein MalA
MX663_18605	COG3833	ABC-type maltose transport systems, permease component
MX663_18610	COG1175	transmembrane transport
MX663_18615	COG2182	Extracellular solute-binding protein
MX663_18620	COG0366	Alpha amylase catalytic
MX663_18625	COG1609	Transcriptional regulator
MX663_18630	COG1611	Belongs to the LOG family
MX663_18635	COG1694	Mazg nucleotide pyrophosphohydrolase
MX663_18640	COG0659	secondary active sulfate transmembrane transporter activity
MX663_18645	COG0288	reversible hydration of carbon dioxide
MX663_18650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
MX663_18655	COG0577	efflux transmembrane transporter activity
MX663_18660	COG1136	(ABC) transporter
MX663_18665	COG5002	protein histidine kinase activity
MX663_18670	COG0745	RESPONSE REGULATOR receiver
MX663_18680	COG2162	N-hydroxyarylamine O-acetyltransferase activity
MX663_18685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
MX663_18690	COG1481	regulation of sporulation
MX663_18695	COG0391	Required for morphogenesis under gluconeogenic growth conditions
MX663_18700	COG1660	Displays ATPase and GTPase activities
MX663_18705	COG1051	belongs to the nudix hydrolase family
MX663_18710	COG0492	ferredoxin-NADP+ reductase activity
MX663_18715	COG3883	PFAM NLP P60 protein
MX663_18715	COG0791	NLP P60 protein
MX663_18720	COG0457	Tetratricopeptide repeat
MX663_18725	COG1132	(ABC) transporter
MX663_18760	COG0140	phosphoribosyl-ATP diphosphatase activity
MX663_18760	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
MX663_18765	COG0107	imidazoleglycerol-phosphate synthase activity
MX663_18770	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
MX663_18775	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
MX663_18780	COG0131	Imidazoleglycerol-phosphate dehydratase
MX663_18785	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
MX663_18790	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
MX663_18795	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
MX663_18800	COG4990	cell redox homeostasis
MX663_18805	COG5297	Belongs to the glycosyl hydrolase family 6
MX663_18810	COG0110	maltose O-acetyltransferase activity
MX663_18815	COG0546	phosphoglycolate phosphatase activity
MX663_18820	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
MX663_18825	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
MX663_18830	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
MX663_18835	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
MX663_18840	COG0363	glucosamine-6-phosphate deaminase activity
MX663_18845	COG2188	Transcriptional regulator
MX663_18850	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
MX663_18855	COG1846	Transcriptional regulator
MX663_18860	COG2124	cytochrome p450
MX663_18870	COG1846	Transcriptional regulator
MX663_18875	COG2814	Major facilitator Superfamily
MX663_18880	COG1950	PFAM Membrane protein of
MX663_18885	COG1983	PspC domain protein
MX663_18890	COG3595	metallopeptidase activity
MX663_18905	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MX663_18910	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
MX663_18915	COG0556	nucleotide-excision repair
MX663_18920	COG4897	Protein conserved in bacteria
MX663_18925	COG3848	Pyruvate phosphate dikinase
MX663_18925	COG0574	Belongs to the PEP-utilizing enzyme family
MX663_18930	COG1309	transcriptional regulator
MX663_18935	COG2814	Major facilitator Superfamily
MX663_18940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MX663_18950	COG3409	Peptidoglycan-binding domain 1 protein
MX663_18950	COG0793	Belongs to the peptidase S41A family
MX663_18955	COG2177	Part of the ABC transporter FtsEX involved in
MX663_18960	COG2884	Cell division ATP-binding protein ftsE
MX663_18965	COG2010	Cytochrome c
MX663_18970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MX663_18980	COG0653	protein targeting
MX663_18985	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
MX663_19000	COG1516	flagellar protein fliS
MX663_19005	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
MX663_19010	COG1334	flagellar protein FlaG
MX663_19015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MX663_19020	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
MX663_19025	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
MX663_19035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
MX663_19040	COG4786	Flagellar basal body rod
MX663_19040	COG1256	bacterial-type flagellum assembly
MX663_19045	COG3418	PFAM FlgN family protein
MX663_19050	COG2747	anti-sigma28 factor FlgM
MX663_19060	COG1040	competence protein
MX663_19070	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
MX663_19075	COG1307	EDD domain protein, DegV family
MX663_19080	COG2197	response regulator
MX663_19085	COG4585	Histidine kinase
MX663_19090	COG1739	Uncharacterized protein family UPF0029
MX663_19095	COG1316	TRANSCRIPTIONal
MX663_19100	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
MX663_19105	COG0438	transferase activity, transferring glycosyl groups
MX663_19110	COG1215	transferase activity, transferring glycosyl groups
MX663_19115	COG3206	protein involved in exopolysaccharide biosynthesis
MX663_19120	COG3307	-O-antigen
MX663_19125	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MX663_19130	COG0438	transferase activity, transferring glycosyl groups
MX663_19130	COG0297	glycogen (starch) synthase activity
MX663_19135	COG2244	polysaccharide biosynthetic process
MX663_19150	COG2247	cell wall binding repeat
MX663_19150	COG0860	N-Acetylmuramoyl-L-alanine amidase
MX663_19155	COG2247	cell wall binding repeat
MX663_19155	COG2385	sporulation resulting in formation of a cellular spore
MX663_19165	COG1316	TRANSCRIPTIONal
MX663_19170	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
MX663_19190	COG1210	Utp--glucose-1-phosphate uridylyltransferase
MX663_19195	COG1134	teichoic acid transport
MX663_19200	COG1682	transport, permease protein
MX663_19215	COG1215	transferase activity, transferring glycosyl groups
MX663_19215	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MX663_19220	COG0463	Glycosyl transferase, family 2
MX663_19265	COG4193	domain, Protein
MX663_19270	COG1482	cell wall glycoprotein biosynthetic process
MX663_19275	COG0697	spore germination
MX663_19280	COG0814	amino acid
MX663_19290	COG2814	Major facilitator Superfamily
MX663_19295	COG1316	TRANSCRIPTIONal
MX663_19300	COG0561	phosphatase activity
MX663_19305	COG0791	NLP P60 protein
MX663_19315	COG2843	Capsule synthesis protein
MX663_19325	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
MX663_19330	COG1609	Transcriptional regulator
MX663_19335	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MX663_19340	COG1869	D-ribose catabolic process
MX663_19345	COG1129	ABC transporter
MX663_19350	COG1172	Belongs to the binding-protein-dependent transport system permease family
MX663_19355	COG1879	ABC-type sugar transport system periplasmic component
MX663_19360	COG3103	Sh3 type 3 domain protein
MX663_19370	COG2249	NAD(P)H dehydrogenase (quinone) activity
MX663_19375	COG3527	Alpha-acetolactate decarboxylase
MX663_19380	COG0028	Belongs to the TPP enzyme family
MX663_19385	COG0583	DNA-binding transcription factor activity
MX663_19390	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
MX663_19405	COG5337	Spore coat protein CotH
MX663_19415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
MX663_19425	COG0405	Gamma-glutamyltransferase
MX663_19430	COG1522	sequence-specific DNA binding
MX663_19435	COG2059	Chromate
MX663_19440	COG2059	Chromate
MX663_19450	COG0655	NAD(P)H dehydrogenase (quinone) activity
MX663_19455	COG0583	DNA-binding transcription factor activity
MX663_19470	COG5444	nuclease activity
MX663_19490	COG3878	Protein conserved in bacteria
MX663_19495	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
MX663_19500	COG4464	protein tyrosine phosphatase activity
MX663_19505	COG0489	protein tyrosine kinase activity
MX663_19510	COG3944	biosynthesis protein
MX663_19520	COG4715	Zinc finger, swim domain protein
MX663_19525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
MX663_19530	COG0561	phosphatase activity
MX663_19535	COG1349	DNA-binding transcription factor activity
MX663_19540	COG0629	single-stranded DNA binding
MX663_19560	COG0745	RESPONSE REGULATOR receiver
MX663_19560	COG2972	Histidine kinase
MX663_19565	COG1970	mechanosensitive ion channel activity
MX663_19570	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
MX663_19575	COG0457	Tetratricopeptide repeat
MX663_19580	COG4786	Flagellar basal body rod
MX663_19585	COG4786	Flagellar basal body rod
MX663_19590	COG1077	Cell shape determining protein MreB Mrl
MX663_19595	COG1609	Transcriptional regulator
MX663_19605	COG1846	Transcriptional regulator
MX663_19610	COG2814	Major facilitator Superfamily
MX663_19615	COG3420	alginic acid biosynthetic process
MX663_19620	COG1953	Uracil, thiamine, allantoin
MX663_19625	COG0477	Major facilitator Superfamily
MX663_19630	COG1335	isochorismatase
MX663_19640	COG0004	ammonium transporteR
MX663_19645	COG0347	Belongs to the P(II) protein family
MX663_19650	COG0671	phosphoesterase, PA-phosphatase related
MX663_19660	COG0739	heme binding
MX663_19665	COG1247	-acetyltransferase
MX663_19685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MX663_19690	COG0789	Transcriptional regulator
MX663_19700	COG2910	NAD(P)H-binding
MX663_19705	COG1959	2 iron, 2 sulfur cluster binding
MX663_19710	COG0804	urea catabolic process
MX663_19715	COG0832	Belongs to the urease beta subunit family
MX663_19720	COG0831	urea catabolic process
MX663_19735	COG3237	CsbD-like
MX663_19740	COG1994	Peptidase M50
MX663_19745	COG0457	Tetratricopeptide repeat
MX663_19750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
MX663_19755	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
MX663_19765	COG2304	oxidoreductase activity
MX663_19775	COG2304	oxidoreductase activity
MX663_19780	COG2385	sporulation resulting in formation of a cellular spore
MX663_19785	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MX663_19795	COG4836	Membrane
MX663_19805	COG0355	proton-transporting ATP synthase activity, rotational mechanism
MX663_19810	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
MX663_19815	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
MX663_19820	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
MX663_19825	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
MX663_19830	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
MX663_19840	COG0356	it plays a direct role in the translocation of protons across the membrane
MX663_19850	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
MX663_19855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
MX663_19860	COG4475	Protein of unknown function (DUF436)
MX663_19865	COG0698	ribose 5-phosphate isomerase
MX663_19870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
MX663_19875	COG1971	Probably functions as a manganese efflux pump
MX663_19880	COG0009	L-threonylcarbamoyladenylate synthase
MX663_19885	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
MX663_19905	COG2890	protein-(glutamine-N5) methyltransferase activity
MX663_19910	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
MX663_19915	COG0346	lactoylglutathione lyase activity
MX663_19920	COG0789	Transcriptional regulator
MX663_19925	COG0679	Auxin Efflux Carrier
MX663_19930	COG0281	malic enzyme
MX663_19935	COG1435	thymidine kinase activity
MX663_19945	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
MX663_19955	COG1494	fructose-1,6-bisphosphatase
MX663_19960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
MX663_19965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
MX663_19970	COG0191	fructose-bisphosphate aldolase activity
MX663_19975	COG2204	response regulator
MX663_19980	COG4821	SIS domain
MX663_19985	COG0504	CTP synthase activity
MX663_19990	COG3343	RNA polymerase activity
MX663_19995	COG1960	acyl-CoA dehydrogenase activity
MX663_20000	COG2181	nitrate reductase activity
MX663_20000	COG0247	lactate metabolic process
MX663_20005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MX663_20010	COG4294	response to UV
MX663_20020	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MX663_20025	COG1132	(ABC) transporter
MX663_20030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
MX663_20040	COG2181	nitrate reductase activity
MX663_20045	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
MX663_20050	COG1140	nitrate reductase beta subunit
MX663_20055	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
MX663_20060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MX663_20070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
MX663_20075	COG2223	nitrite transmembrane transporter activity
MX663_20080	COG0018	arginyl-trna synthetase
MX663_20085	COG4506	Protein conserved in bacteria
MX663_20100	COG0535	radical SAM domain protein
MX663_20110	COG1131	(ABC) transporter
MX663_20115	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
MX663_20120	COG0612	Peptidase, M16
MX663_20125	COG0612	Peptidase, M16
MX663_20135	COG3391	amine dehydrogenase activity
MX663_20140	COG3391	amine dehydrogenase activity
MX663_20145	COG0457	Tetratricopeptide repeat
MX663_20175	COG1131	(ABC) transporter
MX663_20185	COG0010	Belongs to the arginase family
MX663_20190	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
MX663_20195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
MX663_20205	COG1994	Peptidase M50
MX663_20210	COG1942	4-Oxalocrotonate Tautomerase
MX663_20215	COG1846	Transcriptional regulator
MX663_20220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
MX663_20225	COG0477	Major facilitator Superfamily
MX663_20230	COG1959	2 iron, 2 sulfur cluster binding
MX663_20235	COG3465	dGTPase activity
MX663_20240	COG1078	dGTPase activity
MX663_20245	COG4844	belongs to the
MX663_20255	COG0697	spore germination
MX663_20260	COG0095	Lipoate-protein ligase
MX663_20265	COG0583	DNA-binding transcription factor activity
MX663_20270	COG0280	phosphate acetyltransferase
MX663_20275	COG3253	May function as heme-dependent peroxidase
MX663_20280	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_20285	COG0436	Aminotransferase
MX663_20290	COG2814	Major facilitator Superfamily
MX663_20295	COG0151	Belongs to the GarS family
MX663_20300	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_20305	COG1917	Cupin 2, conserved barrel domain protein
MX663_20310	COG0077	Prephenate dehydratase
MX663_20315	COG2814	Major facilitator Superfamily
MX663_20320	COG0833	amino acid
MX663_20325	COG4187	Peptidase family M20/M25/M40
MX663_20330	COG1012	belongs to the aldehyde dehydrogenase family
MX663_20335	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
MX663_20345	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
MX663_20350	COG1091	dTDP-4-dehydrorhamnose reductase activity
MX663_20355	COG1088	dTDP-glucose 4,6-dehydratase activity
MX663_20360	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
MX663_20365	COG3980	spore coat polysaccharide biosynthesis protein
MX663_20370	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
MX663_20375	COG2089	acid synthase
MX663_20380	COG0456	acetyltransferase
MX663_20385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
MX663_20390	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
MX663_20395	COG0463	Glycosyl transferase, family 2
MX663_20405	COG2363	Small membrane protein
MX663_20410	COG2233	PERMEase
MX663_20420	COG1012	belongs to the aldehyde dehydrogenase family
MX663_20425	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
MX663_20430	COG1216	Glycosyl transferase, family 2
MX663_20445	COG1695	Transcriptional regulator
MX663_20450	COG0351	phosphomethylpyrimidine kinase
MX663_20460	COG1621	beta-fructofuranosidase activity
MX663_20465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MX663_20465	COG1263	PTS System
MX663_20470	COG2116	formate transmembrane transporter activity
MX663_20475	COG3711	transcriptional antiterminator
MX663_20485	COG1404	Belongs to the peptidase S8 family
MX663_20490	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MX663_20495	COG0778	Nitroreductase
MX663_20500	COG0772	Belongs to the SEDS family
MX663_20510	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
MX663_20515	COG1845	cytochrome c oxidase, subunit III
MX663_20520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
MX663_20525	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
MX663_20530	COG2261	transglycosylase associated protein
MX663_20535	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
MX663_20540	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
MX663_20545	COG2246	polysaccharide biosynthetic process
MX663_20550	COG1309	transcriptional regulator
MX663_20560	COG3162	membrane
MX663_20565	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
MX663_20570	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
MX663_20575	COG2837	iron assimilation
MX663_20580	COG2822	iron ion transport
MX663_20585	COG0672	)-iron permease
MX663_20590	COG0352	thiamine-phosphate diphosphorylase activity
MX663_20595	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
MX663_20600	COG0583	DNA-binding transcription factor activity
MX663_20605	COG1380	Effector of murein hydrolase LrgA
MX663_20610	COG1346	cytolysis
MX663_20615	COG2814	Major facilitator Superfamily
MX663_20620	COG4895	conserved protein (DUF2196)
MX663_20625	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
MX663_20630	COG0346	lactoylglutathione lyase activity
MX663_20635	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MX663_20640	COG1404	Belongs to the peptidase S8 family
MX663_20645	COG1263	PTS System
MX663_20645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MX663_20650	COG3711	transcriptional antiterminator
MX663_20655	COG1442	glycosyl transferase family 8
MX663_20660	COG5522	Integral membrane protein (intg_mem_TP0381)
MX663_20665	COG1846	Transcriptional regulator
MX663_20670	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
MX663_20675	COG2234	aminopeptidase activity
MX663_20690	COG2814	Major facilitator Superfamily
MX663_20695	COG2357	RelA SpoT domain protein
MX663_20700	COG1575	Belongs to the MenA family. Type 1 subfamily
MX663_20715	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
MX663_20720	COG1696	Membrane protein involved in D-alanine export
MX663_20725	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
MX663_20730	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
MX663_20735	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
MX663_20740	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
MX663_20745	COG1486	melibiose metabolic process
MX663_20750	COG1447	Phosphotransferase system cellobiose-specific component IIA
MX663_20755	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MX663_20760	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
MX663_20765	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
MX663_20765	COG3711	transcriptional antiterminator
MX663_20775	COG2094	Belongs to the DNA glycosylase MPG family
MX663_20780	COG0753	catalase activity
MX663_20785	COG2814	Major facilitator Superfamily
MX663_20790	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
MX663_20795	COG1131	(ABC) transporter
MX663_20815	COG1595	DNA-templated transcription, initiation
MX663_20820	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
MX663_20825	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
MX663_20830	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
MX663_20835	COG4988	ABC transporter
MX663_20840	COG1294	oxidase, subunit
MX663_20845	COG1271	oxidase subunit
MX663_20850	COG3493	citrate carrier protein
MX663_20855	COG0501	Belongs to the peptidase M48B family
MX663_20865	COG0726	polysaccharide deacetylase
MX663_20870	COG3842	ATPase activity
MX663_20875	COG2508	Transcriptional regulator
MX663_20880	COG1012	belongs to the aldehyde dehydrogenase family
MX663_20885	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
MX663_20895	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
MX663_20905	COG4585	Histidine kinase
MX663_20910	COG2197	response regulator
MX663_20915	COG2195	Cleaves the N-terminal amino acid of tripeptides
MX663_20925	COG4894	glucomannan catabolic process
MX663_20930	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MX663_20935	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
MX663_20940	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_20945	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
MX663_20950	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
MX663_20955	COG2610	gluconate transmembrane transporter activity
MX663_20960	COG0500	methyltransferase
MX663_20965	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MX663_20985	COG0693	protein deglycase activity
MX663_20985	COG0753	catalase activity
MX663_20990	COG2851	Citrate transporter
MX663_20995	COG2273	Hydrolase Family 16
MX663_21000	COG3711	transcriptional antiterminator
MX663_21010	COG2270	Major facilitator Superfamily
MX663_21015	COG0513	Belongs to the DEAD box helicase family
MX663_21020	COG2755	lipolytic protein G-D-S-L family
MX663_21020	COG3401	FG-GAP repeat protein
MX663_21050	COG0697	spore germination
MX663_21065	COG0589	response to stress
MX663_21070	COG2723	6-phospho-beta-galactosidase activity
MX663_21075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
MX663_21075	COG1263	PTS System
MX663_21075	COG2190	(PTS) system
MX663_21100	COG5444	nuclease activity
MX663_21120	COG0494	nUDIX hydrolase
MX663_21125	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
MX663_21130	COG3507	Belongs to the glycosyl hydrolase 43 family
MX663_21145	COG2986	histidine ammonia-lyase
MX663_21150	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
MX663_21155	COG1228	amidohydrolase
MX663_21160	COG0010	Belongs to the arginase family
MX663_21165	COG0833	amino acid
MX663_21170	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
MX663_21175	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
MX663_21180	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
MX663_21185	COG2390	Transcriptional regulator
MX663_21195	COG3192	ethanolamine utilization protein
MX663_21200	COG2079	MmgE PrpD family protein
MX663_21205	COG1473	amidohydrolase
MX663_21210	COG1126	abc transporter atp-binding protein
MX663_21215	COG0765	amino acid transport
MX663_21220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
MX663_21225	COG0456	acetyltransferase
MX663_21230	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
MX663_21240	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
MX663_21245	COG0561	phosphatase activity
MX663_21275	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
MX663_21280	COG5294	Protein conserved in bacteria
MX663_21290	COG1136	(ABC) transporter
MX663_21295	COG2205	protein histidine kinase activity
MX663_21300	COG0745	RESPONSE REGULATOR receiver
MX663_21305	COG0191	fructose-bisphosphate aldolase activity
MX663_21310	COG1082	Xylose isomerase domain protein TIM barrel
MX663_21315	COG1082	Xylose isomerase domain protein TIM barrel
MX663_21320	COG0673	inositol 2-dehydrogenase activity
MX663_21325	COG2814	Major facilitator Superfamily
MX663_21330	COG1082	Xylose isomerase domain protein TIM barrel
MX663_21335	COG3962	Belongs to the TPP enzyme family
MX663_21340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
MX663_21350	COG1012	belongs to the aldehyde dehydrogenase family
MX663_21355	COG1349	DNA-binding transcription factor activity
MX663_21360	COG0667	Aldo Keto reductase
MX663_21375	COG2814	Major facilitator Superfamily
MX663_21380	COG0326	Molecular chaperone. Has ATPase activity
MX663_21390	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_21395	COG1309	transcriptional regulator
MX663_21400	COG1012	belongs to the aldehyde dehydrogenase family
MX663_21405	COG1714	RDD family
MX663_21410	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
MX663_21420	COG1714	RDD family
MX663_21425	COG2311	Membrane
MX663_21430	COG1917	Cupin 2, conserved barrel domain protein
MX663_21435	COG1309	transcriptional regulator
MX663_21440	COG1028	Short-chain dehydrogenase reductase Sdr
MX663_21445	COG1846	Transcriptional regulator
MX663_21450	COG1380	Effector of murein hydrolase LrgA
MX663_21455	COG1346	cytolysis
MX663_21460	COG5039	Polysaccharide pyruvyl transferase
MX663_21465	COG1929	Belongs to the glycerate kinase type-1 family
MX663_21470	COG1802	Transcriptional regulator
MX663_21475	COG1070	Carbohydrate kinase
MX663_21480	COG2610	gluconate transmembrane transporter activity
MX663_21485	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
MX663_21490	COG0450	alkyl hydroperoxide reductase
MX663_21495	COG3634	alkyl hydroperoxide reductase activity
MX663_21505	COG2723	6-phospho-beta-galactosidase activity
MX663_21520	COG2188	Transcriptional regulator
MX663_21535	COG1131	(ABC) transporter
MX663_21540	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
MX663_21550	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
MX663_21565	COG1063	alcohol dehydrogenase
MX663_21585	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
MX663_21590	COG0456	acetyltransferase
MX663_21595	COG0457	Tetratricopeptide repeat
MX663_21605	COG0010	Belongs to the arginase family
MX663_21610	COG0833	amino acid
MX663_21615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
MX663_21635	COG5658	integral membrane protein
MX663_21640	COG0640	Transcriptional regulator
MX663_21645	COG3829	transcription factor binding
MX663_21650	COG5002	protein histidine kinase activity
MX663_21655	COG0745	RESPONSE REGULATOR receiver
MX663_21675	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
MX663_21680	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
MX663_21685	COG4853	Protein conserved in bacteria
MX663_21690	COG4863	YycH protein
MX663_21695	COG5002	protein histidine kinase activity
MX663_21700	COG0745	RESPONSE REGULATOR receiver
MX663_21730	COG0346	lactoylglutathione lyase activity
MX663_21735	COG0305	Participates in initiation and elongation during chromosome replication
MX663_21750	COG3093	addiction module antidote protein HigA
MX663_21755	COG2807	transmembrane transport
MX663_21760	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
MX663_21765	COG0359	binds to the 23S rRNA
MX663_21770	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
MX663_21775	COG4241	membrane
MX663_21785	COG5577	PFAM Coat F domain
MX663_21790	COG1733	regulation of RNA biosynthetic process
MX663_21795	COG1227	inorganic diphosphatase activity
MX663_21805	COG2271	Major facilitator Superfamily
MX663_21810	COG4978	Transcriptional regulator
MX663_21810	COG0789	Transcriptional regulator
MX663_21820	COG4319	ketosteroid isomerase
MX663_21825	COG1357	PFAM Pentapeptide repeats (8 copies)
MX663_21830	COG2814	Major facilitator Superfamily
MX663_21835	COG0583	DNA-binding transcription factor activity
MX663_21840	COG2153	protein acetylation
MX663_21855	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
MX663_21860	COG1846	Transcriptional regulator
MX663_21865	COG2153	protein acetylation
MX663_21870	COG2364	Membrane
MX663_21875	COG0456	acetyltransferase
MX663_21880	COG2315	Protein conserved in bacteria
MX663_21885	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
MX663_21895	COG2814	Major facilitator Superfamily
MX663_21900	COG1331	Highly conserved protein containing a thioredoxin domain
MX663_21905	COG1266	CAAX protease self-immunity
MX663_21910	COG0477	Major facilitator Superfamily
MX663_21910	COG2814	Major facilitator Superfamily
MX663_21915	COG0110	maltose O-acetyltransferase activity
MX663_21920	COG0346	lactoylglutathione lyase activity
MX663_21925	COG1609	Transcriptional regulator
MX663_21930	COG0708	Exodeoxyribonuclease III
MX663_21935	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
MX663_21940	COG0629	single-stranded DNA binding
MX663_21945	COG0360	Binds together with S18 to 16S ribosomal RNA
MX663_21950	COG0012	GTP binding
MX663_21955	COG0243	molybdopterin cofactor binding
MX663_21960	COG4481	Protein conserved in bacteria
MX663_21965	COG3949	Membrane
MX663_21975	COG1475	DNA binding
MX663_21980	COG1192	Involved in chromosome partitioning
MX663_21990	COG1475	DNA binding
MX663_21995	COG0357	Ribosomal RNA small subunit methyltransferase G
MX663_22000	COG0445	tRNA wobble uridine modification
MX663_22005	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
MX663_22010	COG1847	R3H domain protein
MX663_22015	COG0706	membrane insertase activity
MX663_22020	COG0594	ribonuclease P activity