locus-tag	class	description
B4U62_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B4U62_00010	COG0592	DNA-directed DNA polymerase activity
B4U62_00015	COG2501	S4 domain
B4U62_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B4U62_00030	COG0187	DNA topoisomerase II activity
B4U62_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B4U62_00070	COG0516	GMP reductase activity
B4U62_00070	COG0517	IMP dehydrogenase activity
B4U62_00075	COG1686	Belongs to the peptidase S11 family
B4U62_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B4U62_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B4U62_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B4U62_00100	COG1428	Deoxynucleoside kinase
B4U62_00105	COG1428	Deoxynucleoside kinase
B4U62_00110	COG1388	LysM domain
B4U62_00110	COG3858	chitin binding
B4U62_00115	COG1335	isochorismatase
B4U62_00120	COG0590	tRNA wobble adenosine to inosine editing
B4U62_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B4U62_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B4U62_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B4U62_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
B4U62_00190	COG3853	Toxic anion resistance protein (TelA)
B4U62_00195	COG1982	Orn Lys Arg decarboxylase major
B4U62_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B4U62_00205	COG3870	Protein conserved in bacteria
B4U62_00210	COG1728	Protein conserved in bacteria
B4U62_00215	COG0470	DNA polymerase III
B4U62_00220	COG1774	PSP1 C-terminal conserved region
B4U62_00225	COG4467	Involved in initiation control of chromosome replication
B4U62_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B4U62_00235	COG2827	Endonuclease containing a URI domain
B4U62_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B4U62_00245	COG2002	toxin-antitoxin pair type II binding
B4U62_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4U62_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4U62_00255	COG0084	hydrolase, TatD family'
B4U62_00260	COG3584	3D domain protein
B4U62_00260	COG3583	domain protein
B4U62_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B4U62_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B4U62_00280	COG4466	Protein conserved in bacteria
B4U62_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B4U62_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B4U62_00300	COG0251	oxidation-reduction process
B4U62_00305	COG2088	sporulation resulting in formation of a cellular spore
B4U62_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B4U62_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B4U62_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B4U62_00325	COG0193	aminoacyl-tRNA hydrolase activity
B4U62_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B4U62_00340	COG2002	toxin-antitoxin pair type II binding
B4U62_00345	COG2244	polysaccharide biosynthetic process
B4U62_00350	COG3956	TIGRFAM MazG family protein
B4U62_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B4U62_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B4U62_00375	COG1098	S1 RNA binding domain
B4U62_00390	COG2208	phosphoserine phosphatase activity
B4U62_00395	COG2304	oxidoreductase activity
B4U62_00400	COG0515	serine threonine protein kinase
B4U62_00405	COG0037	tRNA processing
B4U62_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B4U62_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B4U62_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B4U62_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B4U62_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4U62_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B4U62_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
B4U62_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4U62_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B4U62_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B4U62_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B4U62_00470	COG1396	sequence-specific DNA binding
B4U62_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B4U62_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B4U62_00560	COG4463	regulation of RNA biosynthetic process
B4U62_00565	COG3880	PFAM UvrB UvrC protein
B4U62_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
B4U62_00575	COG0542	response to heat
B4U62_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B4U62_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
B4U62_00590	COG4956	integral membrane protein (PIN domain superfamily)
B4U62_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B4U62_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B4U62_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B4U62_00620	COG0215	cysteine-tRNA ligase activity
B4U62_00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
B4U62_00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4U62_00635	COG3688	RNA-binding protein containing a PIN domain
B4U62_00640	COG1595	DNA-templated transcription, initiation
B4U62_00645	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B4U62_00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B4U62_00655	COG0250	Participates in transcription elongation, termination and antitermination
B4U62_00660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B4U62_00665	COG0081	regulation of translation
B4U62_00670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B4U62_00675	COG0222	ribosome binding
B4U62_00680	COG2813	Specifically methylates the guanine in position
B4U62_00685	COG0085	RNA polymerase activity
B4U62_00690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B4U62_00695	COG1358	cellular component organization or biogenesis
B4U62_00700	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B4U62_00705	COG0049	tRNA binding
B4U62_00710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B4U62_00715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B4U62_00720	COG0596	Alpha beta hydrolase
B4U62_00725	COG0051	transcription antitermination factor activity, RNA binding
B4U62_00730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B4U62_00735	COG0088	Forms part of the polypeptide exit tunnel
B4U62_00740	COG0089	rRNA binding
B4U62_00745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B4U62_00750	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B4U62_00755	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B4U62_00760	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B4U62_00765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B4U62_00770	COG0255	Belongs to the universal ribosomal protein uL29 family
B4U62_00775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B4U62_00780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B4U62_00790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B4U62_00800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B4U62_00805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B4U62_00810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B4U62_00815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B4U62_00820	COG1841	ribosomal large subunit assembly
B4U62_00825	COG0200	Binds to the 23S rRNA
B4U62_00830	COG0201	protein transport
B4U62_00835	COG0563	adenylate kinase activity
B4U62_00840	COG0024	Methionine aminopeptidase
B4U62_00845	COG2163	COG2163 Ribosomal protein L14E L6E L27E
B4U62_00850	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B4U62_00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B4U62_00860	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B4U62_00865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B4U62_00870	COG0202	RNA polymerase activity
B4U62_00875	COG0203	ribosomal protein L17
B4U62_00880	COG1122	ATPase activity
B4U62_00885	COG1122	ATPase activity
B4U62_00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B4U62_00895	COG0101	tRNA pseudouridine synthase activity
B4U62_00900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B4U62_00905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B4U62_00910	COG2226	methyltransferase
B4U62_00920	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U62_00925	COG0489	protein tyrosine kinase activity
B4U62_00935	COG2194	sulfuric ester hydrolase activity
B4U62_00940	COG0726	polysaccharide deacetylase
B4U62_01025	COG0659	secondary active sulfate transmembrane transporter activity
B4U62_01030	COG0385	Bile acid
B4U62_01035	COG2819	hydrolase of the alpha beta superfamily
B4U62_01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U62_01045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U62_01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4U62_01055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4U62_01055	COG2207	Transcriptional regulator
B4U62_01060	COG3876	Protein conserved in bacteria
B4U62_01065	COG1472	Belongs to the glycosyl hydrolase 3 family
B4U62_01070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B4U62_01075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U62_01075	COG1263	PTS System
B4U62_01080	COG1737	Transcriptional regulator
B4U62_01085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B4U62_01090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U62_01095	COG1683	Conserved Protein
B4U62_01125	COG1595	DNA-templated transcription, initiation
B4U62_01130	COG5662	AntiSigma factor
B4U62_01135	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B4U62_01140	COG4856	YbbR-like protein
B4U62_01145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B4U62_01150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B4U62_01155	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B4U62_01160	COG2169	Transcriptional regulator
B4U62_01165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B4U62_01170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B4U62_01175	COG3002	Belongs to the UPF0753 family
B4U62_01180	COG0288	reversible hydration of carbon dioxide
B4U62_01190	COG5609	conserved protein (DUF2294)
B4U62_01195	COG0640	Transcriptional regulator
B4U62_01200	COG2814	Major facilitator Superfamily
B4U62_01205	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B4U62_01215	COG0535	radical SAM domain protein
B4U62_01220	COG1266	CAAX protease self-immunity
B4U62_01225	COG1131	(ABC) transporter
B4U62_01235	COG1413	lyase activity
B4U62_01240	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U62_01245	COG0596	Alpha beta hydrolase
B4U62_01250	COG0745	RESPONSE REGULATOR receiver
B4U62_01255	COG0642	Histidine kinase
B4U62_01265	COG0515	serine threonine protein kinase
B4U62_01280	COG1113	amino acid transport
B4U62_01295	COG2602	Beta-lactamase
B4U62_01300	COG2124	cytochrome p450
B4U62_01310	COG0531	amino acid
B4U62_01315	COG0584	glycerophosphoryl diester phosphodiesterase
B4U62_01320	COG2271	Major facilitator Superfamily
B4U62_01335	COG1846	Transcriptional regulator
B4U62_01335	COG0456	acetyltransferase
B4U62_01340	COG2271	Major facilitator Superfamily
B4U62_01355	COG3409	Peptidoglycan-binding domain 1 protein
B4U62_01360	COG0697	spore germination
B4U62_01365	COG1917	Cupin 2, conserved barrel domain protein
B4U62_01365	COG2207	Transcriptional regulator
B4U62_01370	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B4U62_01375	COG3591	Belongs to the peptidase S1B family
B4U62_01385	COG0596	Alpha beta hydrolase
B4U62_01390	COG1183	phosphatidylcholine synthase activity
B4U62_01395	COG0586	Pfam SNARE associated Golgi protein
B4U62_01400	COG0688	phosphatidylethanolamine metabolic process
B4U62_01410	COG2312	Erythromycin esterase
B4U62_01415	COG2207	Transcriptional regulator
B4U62_01425	COG1301	dicarboxylic acid transport
B4U62_01430	COG2190	(PTS) system
B4U62_01430	COG1263	PTS System
B4U62_01430	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U62_01435	COG0363	glucosamine-6-phosphate deaminase activity
B4U62_01450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4U62_01455	COG0833	amino acid
B4U62_01460	COG2040	homocysteine
B4U62_01470	COG1115	amino acid carrier protein
B4U62_01475	COG2066	Belongs to the glutaminase family
B4U62_01480	COG4191	Histidine kinase
B4U62_01485	COG0784	Response regulator, receiver
B4U62_01495	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B4U62_01500	COG1012	belongs to the aldehyde dehydrogenase family
B4U62_01505	COG2271	Major facilitator Superfamily
B4U62_01510	COG4948	Mandelate Racemase Muconate Lactonizing
B4U62_01515	COG2186	Transcriptional regulator
B4U62_01520	COG2721	sulfolactate sulfo-lyase activity
B4U62_01525	COG3173	Aminoglycoside phosphotransferase
B4U62_01535	COG0697	spore germination
B4U62_01540	COG0745	RESPONSE REGULATOR receiver
B4U62_01545	COG2205	protein histidine kinase activity
B4U62_01550	COG1131	(ABC) transporter
B4U62_01565	COG3773	Cell wall hydrolase
B4U62_01570	COG2304	oxidoreductase activity
B4U62_01580	COG3540	Alkaline phosphatase
B4U62_01585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B4U62_01590	COG0805	protein transport
B4U62_01595	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
B4U62_01600	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B4U62_01605	COG0477	Major facilitator Superfamily
B4U62_01610	COG1309	transcriptional regulator
B4U62_01615	COG0252	asparaginase activity
B4U62_01620	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B4U62_01625	COG1714	RDD family
B4U62_01630	COG1405	negative regulation of cell septum assembly
B4U62_01630	COG3012	SEC-C Motif Domain Protein
B4U62_01635	COG3290	protein histidine kinase activity
B4U62_01640	COG3279	Response regulator of the LytR AlgR family
B4U62_01645	COG4555	ABC transporter
B4U62_01650	COG1668	transmembrane transport
B4U62_01655	COG0667	Aldo Keto reductase
B4U62_01665	COG1595	DNA-templated transcription, initiation
B4U62_01675	COG1595	DNA-templated transcription, initiation
B4U62_01680	COG1876	peptidase activity
B4U62_01685	COG0457	Tetratricopeptide repeat
B4U62_01690	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_01695	COG0366	Alpha amylase catalytic
B4U62_01700	COG0803	Belongs to the bacterial solute-binding protein 9 family
B4U62_01705	COG1121	(ABC) transporter
B4U62_01710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4U62_01715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U62_01725	COG2310	stress, protein
B4U62_01730	COG2310	stress, protein
B4U62_01735	COG0861	Integral membrane protein TerC family
B4U62_01745	COG3853	Toxic anion resistance protein (TelA)
B4U62_01750	COG0477	Major facilitator Superfamily
B4U62_01760	COG2814	Major facilitator Superfamily
B4U62_01765	COG0640	Transcriptional regulator
B4U62_01770	COG0517	IMP dehydrogenase activity
B4U62_01770	COG4175	Glycine betaine
B4U62_01775	COG4176	ABC-type proline glycine betaine transport system permease component
B4U62_01780	COG2113	Glycine betaine
B4U62_01785	COG1473	amidohydrolase
B4U62_01790	COG1288	antiporter activity
B4U62_01800	COG0366	Alpha amylase catalytic
B4U62_01805	COG0039	L-malate dehydrogenase activity
B4U62_01810	COG1620	l-lactate permease
B4U62_01815	COG2814	Major facilitator Superfamily
B4U62_01820	COG1846	Transcriptional regulator
B4U62_01825	COG1280	lysine exporter protein (LysE YggA)
B4U62_01830	COG3403	YqcI/YcgG family
B4U62_01835	COG1113	amino acid transport
B4U62_01840	COG3665	Urea carboxylase-associated protein
B4U62_01845	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B4U62_01850	COG1660	Displays ATPase and GTPase activities
B4U62_01860	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
B4U62_01865	COG2226	methyltransferase
B4U62_01870	COG0583	DNA-binding transcription factor activity
B4U62_01875	COG3458	cephalosporin-C deacetylase activity
B4U62_01880	COG3541	Predicted nucleotidyltransferase
B4U62_01885	COG0506	proline dehydrogenase activity
B4U62_01890	COG1012	belongs to the aldehyde dehydrogenase family
B4U62_01895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4U62_01900	COG2508	Transcriptional regulator
B4U62_01905	COG3689	TIGRFAM TIGR03943 family protein
B4U62_01910	COG0701	Predicted permease
B4U62_01915	COG2267	carboxylic ester hydrolase activity
B4U62_01920	COG0492	ferredoxin-NADP+ reductase activity
B4U62_01925	COG1587	Uroporphyrinogen-III synthase
B4U62_01925	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B4U62_01930	COG2146	nitrite reductase [NAD(P)H] activity
B4U62_01935	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B4U62_01940	COG0243	molybdopterin cofactor binding
B4U62_01945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B4U62_01950	COG2223	nitrite transmembrane transporter activity
B4U62_01955	COG1469	GTP cyclohydrolase I activity
B4U62_01960	COG1376	ErfK ybiS ycfS ynhG family protein
B4U62_01970	COG0523	cobalamin synthesis protein
B4U62_01975	COG0765	amino acid transport
B4U62_01980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4U62_01985	COG1714	RDD family
B4U62_01995	COG2723	6-phospho-beta-galactosidase activity
B4U62_02005	COG3209	COG3209 Rhs family protein
B4U62_02010	COG0840	transmembrane signaling receptor activity
B4U62_02010	COG3290	protein histidine kinase activity
B4U62_02015	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B4U62_02020	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
B4U62_02025	COG1733	regulation of RNA biosynthetic process
B4U62_02030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U62_02035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U62_02040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U62_02045	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
B4U62_02050	COG2814	Major facilitator Superfamily
B4U62_02060	COG0697	spore germination
B4U62_02065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4U62_02075	COG2364	Membrane
B4U62_02080	COG1126	abc transporter atp-binding protein
B4U62_02085	COG0765	amino acid transport
B4U62_02090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4U62_02095	COG0583	DNA-binding transcription factor activity
B4U62_02100	COG0163	prenyltransferase activity
B4U62_02105	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B4U62_02120	COG0596	Alpha beta hydrolase
B4U62_02125	COG3104	oligopeptide transport
B4U62_02130	COG5434	Belongs to the glycosyl hydrolase 28 family
B4U62_02140	COG0697	spore germination
B4U62_02150	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B4U62_02155	COG1136	(ABC) transporter
B4U62_02160	COG0577	efflux transmembrane transporter activity
B4U62_02165	COG0745	RESPONSE REGULATOR receiver
B4U62_02170	COG5002	protein histidine kinase activity
B4U62_02170	COG3850	Histidine kinase
B4U62_02175	COG0457	Tetratricopeptide repeat
B4U62_02195	COG0527	aspartate kinase activity
B4U62_02200	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U62_02205	COG4605	iron ion homeostasis
B4U62_02210	COG4604	ABC transporter, ATP-binding protein
B4U62_02215	COG4607	ABC-type enterochelin transport system periplasmic component
B4U62_02220	COG2814	Major facilitator Superfamily
B4U62_02225	COG1309	transcriptional regulator
B4U62_02230	COG0778	Nitroreductase
B4U62_02235	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
B4U62_02240	COG0640	Transcriptional regulator
B4U62_02245	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4U62_02250	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B4U62_02255	COG1012	belongs to the aldehyde dehydrogenase family
B4U62_02260	COG4975	Glucose uptake
B4U62_02265	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_02270	COG4549	nuclear export factor GLE1
B4U62_02275	COG1276	copper resistance
B4U62_02275	COG2372	response to copper ion
B4U62_02280	COG1349	DNA-binding transcription factor activity
B4U62_02290	COG2213	PTS system mannitol-specific
B4U62_02295	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4U62_02300	COG0246	Mannitol dehydrogenase
B4U62_02305	COG0473	3-isopropylmalate dehydrogenase activity
B4U62_02310	COG0681	Belongs to the peptidase S26 family
B4U62_02315	COG0412	Dienelactone hydrolase
B4U62_02320	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B4U62_02330	COG0561	phosphatase activity
B4U62_02335	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B4U62_02340	COG1914	H( )-stimulated, divalent metal cation uptake system
B4U62_02345	COG4336	lyase activity
B4U62_02350	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B4U62_02355	COG1984	allophanate hydrolase subunit 2
B4U62_02360	COG1414	Transcriptional regulator
B4U62_02365	COG2755	lipolytic protein G-D-S-L family
B4U62_02375	COG2329	Antibiotic biosynthesis monooxygenase
B4U62_02380	COG0768	penicillin binding
B4U62_02385	COG4989	oxidoreductase activity
B4U62_02390	COG3711	transcriptional antiterminator
B4U62_02395	COG0318	PFAM AMP-dependent synthetase and ligase
B4U62_02400	COG2226	methyltransferase
B4U62_02405	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_02410	COG1917	Cupin 2, conserved barrel domain protein
B4U62_02415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U62_02420	COG3871	stress protein (general stress protein 26)
B4U62_02430	COG2814	Major facilitator Superfamily
B4U62_02435	COG1522	sequence-specific DNA binding
B4U62_02440	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B4U62_02440	COG0551	DNA topoisomerase type I activity
B4U62_02445	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
B4U62_02450	COG3706	GGDEF domain
B4U62_02455	COG5298	Protein conserved in bacteria
B4U62_02460	COG1215	transferase activity, transferring glycosyl groups
B4U62_02470	COG0531	amino acid
B4U62_02475	COG0494	nUDIX hydrolase
B4U62_02480	COG0028	Belongs to the TPP enzyme family
B4U62_02495	COG1914	H( )-stimulated, divalent metal cation uptake system
B4U62_02500	COG2261	transglycosylase associated protein
B4U62_02505	COG4876	unkown
B4U62_02510	COG2217	Heavy metal translocating P-type atpase
B4U62_02515	COG3729	General stress protein
B4U62_02520	COG0662	Cupin 2, conserved barrel domain protein
B4U62_02525	COG2329	Antibiotic biosynthesis monooxygenase
B4U62_02530	COG3546	catalase activity
B4U62_02535	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B4U62_02540	COG3290	protein histidine kinase activity
B4U62_02545	COG4565	transcriptional regulatory protein
B4U62_02550	COG1301	dicarboxylic acid transport
B4U62_02555	COG0628	permease
B4U62_02560	COG1131	(ABC) transporter
B4U62_02565	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B4U62_02575	COG1960	acyl-CoA dehydrogenase activity
B4U62_02590	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B4U62_02595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U62_02600	COG1181	Belongs to the D-alanine--D-alanine ligase family
B4U62_02605	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B4U62_02615	COG0513	Belongs to the DEAD box helicase family
B4U62_02620	COG3402	PFAM membrane-flanked domain
B4U62_02625	COG3428	Bacterial PH domain
B4U62_02630	COG0705	Rhomboid family
B4U62_02635	COG0736	holo-[acyl-carrier-protein] synthase activity
B4U62_02640	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B4U62_02645	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B4U62_02650	COG0864	Transcriptional regulator
B4U62_02655	COG2337	Toxic component of a toxin-antitoxin (TA) module
B4U62_02660	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U62_02665	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U62_02670	COG2172	sigma factor antagonist activity
B4U62_02675	COG2208	phosphoserine phosphatase activity
B4U62_02680	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U62_02685	COG2172	sigma factor antagonist activity
B4U62_02690	COG1191	sigma factor activity
B4U62_02695	COG2208	phosphoserine phosphatase activity
B4U62_02710	COG1673	EVE domain
B4U62_02715	COG1846	Transcriptional regulator
B4U62_02720	COG2183	response to ionizing radiation
B4U62_02725	COG3091	SprT-like family
B4U62_02765	COG0582	viral genome integration into host DNA
B4U62_02770	COG2856	Zn peptidase
B4U62_02775	COG1396	sequence-specific DNA binding
B4U62_02800	COG1674	ftsk spoiiie
B4U62_02805	COG2946	Replication initiation factor
B4U62_02840	COG0433	COG0433 Predicted ATPase
B4U62_02850	COG5644	endopeptidase inhibitor activity
B4U62_02855	COG0741	lytic transglycosylase activity
B4U62_02855	COG0791	NLP P60 protein
B4U62_02875	COG0457	Tetratricopeptide repeat
B4U62_02890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U62_02895	COG1522	sequence-specific DNA binding
B4U62_02900	COG1522	sequence-specific DNA binding
B4U62_02905	COG1335	isochorismatase
B4U62_02910	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B4U62_02915	COG2814	Major facilitator Superfamily
B4U62_02935	COG0693	protein deglycase activity
B4U62_02940	COG1278	Cold shock
B4U62_02945	COG1329	Transcriptional regulator
B4U62_02955	COG0697	spore germination
B4U62_02960	COG1917	Cupin 2, conserved barrel domain protein
B4U62_02960	COG2207	Transcriptional regulator
B4U62_02965	COG0697	spore germination
B4U62_02970	COG3708	Transcriptional regulator
B4U62_02970	COG2207	Transcriptional regulator
B4U62_02975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4U62_02980	COG0477	Major facilitator Superfamily
B4U62_02990	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
B4U62_03000	COG0697	spore germination
B4U62_03005	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4U62_03010	COG2030	dehydratase
B4U62_03015	COG3545	Serine hydrolase
B4U62_03020	COG1733	regulation of RNA biosynthetic process
B4U62_03025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4U62_03030	COG1733	regulation of RNA biosynthetic process
B4U62_03035	COG2249	NAD(P)H dehydrogenase (quinone) activity
B4U62_03040	COG2814	Major facilitator Superfamily
B4U62_03045	COG1309	transcriptional regulator
B4U62_03055	COG0640	Transcriptional regulator
B4U62_03060	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B4U62_03070	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U62_03075	COG0697	spore germination
B4U62_03080	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4U62_03085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B4U62_03090	COG0640	Transcriptional regulator
B4U62_03095	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B4U62_03110	COG4585	Histidine kinase
B4U62_03115	COG2197	response regulator
B4U62_03120	COG2409	Drug exporters of the RND superfamily
B4U62_03125	COG0596	Alpha beta hydrolase
B4U62_03130	COG1811	Na channel or pump
B4U62_03135	COG0789	Transcriptional regulator
B4U62_03135	COG4978	Transcriptional regulator
B4U62_03140	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B4U62_03145	COG0778	Nitroreductase
B4U62_03150	COG0346	lactoylglutathione lyase activity
B4U62_03155	COG2259	Doxx family
B4U62_03160	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U62_03175	COG2323	membrane
B4U62_03180	COG2323	membrane
B4U62_03185	COG0071	Belongs to the small heat shock protein (HSP20) family
B4U62_03200	COG1309	transcriptional regulator
B4U62_03210	COG0456	acetyltransferase
B4U62_03220	COG1113	amino acid transport
B4U62_03225	COG2318	DinB family
B4U62_03230	COG1846	Transcriptional regulator
B4U62_03235	COG2409	Drug exporters of the RND superfamily
B4U62_03235	COG1033	growth of symbiont in host cell
B4U62_03240	COG0778	Nitroreductase
B4U62_03245	COG1846	Transcriptional regulator
B4U62_03250	COG2814	Major facilitator Superfamily
B4U62_03255	COG0730	response to heat
B4U62_03260	COG1802	Transcriptional regulator
B4U62_03265	COG1388	LysM domain
B4U62_03265	COG3858	chitin binding
B4U62_03270	COG1819	glycosyl
B4U62_03280	COG1785	Belongs to the alkaline phosphatase family
B4U62_03285	COG5646	InterPro IPR014922
B4U62_03295	COG0454	-acetyltransferase
B4U62_03300	COG1078	dGTPase activity
B4U62_03305	COG1388	LysM domain
B4U62_03310	COG2814	Major facilitator Superfamily
B4U62_03315	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4U62_03320	COG1447	Phosphotransferase system cellobiose-specific component IIA
B4U62_03325	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4U62_03330	COG2723	6-phospho-beta-galactosidase activity
B4U62_03335	COG2188	Transcriptional regulator
B4U62_03340	COG1940	carbohydrate kinase activity
B4U62_03345	COG1482	cell wall glycoprotein biosynthetic process
B4U62_03350	COG4124	Belongs to the glycosyl hydrolase 26 family
B4U62_03395	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B4U62_03400	COG0802	atpase or kinase
B4U62_03405	COG1214	PFAM Peptidase M22, glycoprotease
B4U62_03410	COG0456	acetyltransferase
B4U62_03415	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B4U62_03420	COG0488	(ABC) transporter
B4U62_03425	COG0315	cyclic pyranopterin monophosphate synthase activity
B4U62_03430	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
B4U62_03435	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B4U62_03440	COG0805	protein transport
B4U62_03450	COG1266	CAAX protease self-immunity
B4U62_03455	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B4U62_03460	COG0459	protein refolding
B4U62_03475	COG3378	Phage plasmid primase P4 family
B4U62_03490	COG0270	DNA (cytosine-5-)-methyltransferase activity
B4U62_03495	COG0270	DNA (cytosine-5-)-methyltransferase activity
B4U62_03510	COG1401	restriction endodeoxyribonuclease activity
B4U62_03530	COG1073	alpha beta
B4U62_03535	COG0457	Tetratricopeptide repeat
B4U62_03540	COG1063	alcohol dehydrogenase
B4U62_03545	COG2211	Major facilitator Superfamily
B4U62_03550	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4U62_03555	COG1842	Phage shock protein A
B4U62_03560	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B4U62_03565	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
B4U62_03570	COG4260	virion core protein, lumpy skin disease virus
B4U62_03580	COG2814	Major facilitator Superfamily
B4U62_03585	COG1063	alcohol dehydrogenase
B4U62_03590	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B4U62_03595	COG0823	Involved in the tonB-independent uptake of proteins
B4U62_03610	COG2267	carboxylic ester hydrolase activity
B4U62_03620	COG2132	Multicopper oxidase
B4U62_03625	COG1113	amino acid transport
B4U62_03635	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B4U62_03640	COG0714	Associated with various cellular activities
B4U62_03645	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
B4U62_03650	COG1305	Transglutaminase-like
B4U62_03655	COG0519	Catalyzes the synthesis of GMP from XMP
B4U62_03655	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B4U62_03660	COG2252	PERMEase
B4U62_03665	COG3064	Membrane
B4U62_03675	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
B4U62_03685	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B4U62_03690	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B4U62_03695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B4U62_03700	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B4U62_03705	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B4U62_03710	COG0047	phosphoribosylformylglycinamidine synthase activity
B4U62_03715	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B4U62_03720	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B4U62_03725	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B4U62_03730	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B4U62_03735	COG0138	bifunctional purine biosynthesis protein purh
B4U62_03740	COG0151	Belongs to the GarS family
B4U62_03745	COG1522	sequence-specific DNA binding
B4U62_03750	COG0531	amino acid
B4U62_03760	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B4U62_03765	COG1470	cell adhesion involved in biofilm formation
B4U62_03770	COG4496	protein, YerC YecD
B4U62_03775	COG0069	glutamate synthase activity
B4U62_03780	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
B4U62_03785	COG0210	DNA helicase
B4U62_03790	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B4U62_03800	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B4U62_03810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4U62_03815	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B4U62_03820	COG0154	amidase activity
B4U62_03825	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B4U62_03830	COG1309	transcriptional regulator
B4U62_03835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B4U62_03840	COG1597	lipid kinase activity
B4U62_03845	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B4U62_03850	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B4U62_03855	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B4U62_03860	COG1002	Type II restriction enzyme, methylase subunits
B4U62_03865	COG1061	Type III restriction enzyme res subunit
B4U62_03870	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B4U62_03890	COG5444	nuclease activity
B4U62_03895	COG3391	amine dehydrogenase activity
B4U62_03900	COG0457	Tetratricopeptide repeat
B4U62_03910	COG0217	transcriptional regulatory protein
B4U62_03920	COG1309	transcriptional regulator
B4U62_03925	COG3631	Ketosteroid isomerase-related protein
B4U62_03930	COG0702	epimerase
B4U62_03945	COG3546	catalase activity
B4U62_03950	COG0454	-acetyltransferase
B4U62_03960	COG5578	integral membrane protein
B4U62_03965	COG2972	Histidine kinase
B4U62_03970	COG2207	Transcriptional regulator
B4U62_03970	COG4753	response regulator
B4U62_03975	COG1653	transport
B4U62_03980	COG1175	transmembrane transport
B4U62_03985	COG0395	ABC-type sugar transport system, permease component
B4U62_03990	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
B4U62_03995	COG2207	Transcriptional regulator
B4U62_04000	COG2755	lipolytic protein G-D-S-L family
B4U62_04010	COG5578	integral membrane protein
B4U62_04015	COG3401	FG-GAP repeat protein
B4U62_04020	COG3401	FG-GAP repeat protein
B4U62_04025	COG2755	lipolytic protein G-D-S-L family
B4U62_04030	COG1874	Beta-galactosidase
B4U62_04040	COG1653	transport
B4U62_04045	COG4209	transmembrane transport
B4U62_04050	COG0395	ABC-type sugar transport system, permease component
B4U62_04055	COG1486	melibiose metabolic process
B4U62_04060	COG2323	membrane
B4U62_04065	COG2329	Antibiotic biosynthesis monooxygenase
B4U62_04070	COG0346	lactoylglutathione lyase activity
B4U62_04085	COG5583	Uncharacterized small protein (DUF2292)
B4U62_04090	COG0670	Belongs to the BI1 family
B4U62_04095	COG0697	spore germination
B4U62_04100	COG1846	Transcriptional regulator
B4U62_04105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B4U62_04115	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B4U62_04115	COG2124	cytochrome p450
B4U62_04120	COG1368	sulfuric ester hydrolase activity
B4U62_04125	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B4U62_04130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B4U62_04135	COG1442	glycosyl transferase family 8
B4U62_04140	COG1216	Glycosyl transferase, family 2
B4U62_04145	COG1442	glycosyl transferase family 8
B4U62_04150	COG2223	nitrite transmembrane transporter activity
B4U62_04155	COG1011	Hydrolase
B4U62_04160	COG0531	amino acid
B4U62_04165	COG1012	belongs to the aldehyde dehydrogenase family
B4U62_04170	COG0840	transmembrane signaling receptor activity
B4U62_04175	COG0488	(ABC) transporter
B4U62_04185	COG0789	Transcriptional regulator
B4U62_04190	COG2814	Major facilitator Superfamily
B4U62_04205	COG0488	(ABC) transporter
B4U62_04210	COG0513	Belongs to the DEAD box helicase family
B4U62_04215	COG0456	acetyltransferase
B4U62_04220	COG2130	NADP-dependent
B4U62_04230	COG2211	Major facilitator Superfamily
B4U62_04235	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B4U62_04240	COG1120	ATPase activity
B4U62_04245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U62_04250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U62_04255	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B4U62_04275	COG3866	Pectate lyase
B4U62_04280	COG0471	metal ion transport
B4U62_04285	COG3290	protein histidine kinase activity
B4U62_04290	COG4565	transcriptional regulatory protein
B4U62_04295	COG3181	Tripartite tricarboxylate transporter family receptor
B4U62_04300	COG2851	Citrate transporter
B4U62_04305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4U62_04310	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
B4U62_04315	COG1254	Belongs to the acylphosphatase family
B4U62_04320	COG2258	MOSC domain
B4U62_04340	COG0024	Methionine aminopeptidase
B4U62_04345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U62_04345	COG1263	PTS System
B4U62_04350	COG1368	sulfuric ester hydrolase activity
B4U62_04365	COG1115	amino acid carrier protein
B4U62_04370	COG0531	amino acid
B4U62_04385	COG0697	spore germination
B4U62_04390	COG1263	PTS System
B4U62_04390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U62_04395	COG0366	Alpha amylase catalytic
B4U62_04400	COG2188	Transcriptional regulator
B4U62_04405	COG0778	Nitroreductase
B4U62_04410	COG0737	Belongs to the 5'-nucleotidase family
B4U62_04415	COG0693	protein deglycase activity
B4U62_04420	COG2814	Major facilitator Superfamily
B4U62_04425	COG4840	Belongs to the UPF0435 family
B4U62_04430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B4U62_04435	COG4980	gas vesicle protein
B4U62_04440	COG1295	ribonuclease BN
B4U62_04445	COG0477	Major facilitator Superfamily
B4U62_04450	COG0387	Pfam Sodium calcium exchanger
B4U62_04460	COG0668	transmembrane transport
B4U62_04465	COG0535	radical SAM domain protein
B4U62_04475	COG0726	polysaccharide deacetylase
B4U62_04480	COG2084	Dehydrogenase
B4U62_04485	COG0598	Magnesium transport protein CorA
B4U62_04490	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B4U62_04495	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B4U62_04505	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B4U62_04510	COG4637	Psort location Cytoplasmic, score
B4U62_04520	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B4U62_04525	COG0022	dehydrogenase e1 component
B4U62_04530	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4U62_04540	COG3284	Transcriptional regulator
B4U62_04550	COG1742	UPF0060 membrane protein
B4U62_04575	COG4842	Belongs to the WXG100 family
B4U62_04580	COG1486	melibiose metabolic process
B4U62_04585	COG1737	Transcriptional regulator
B4U62_04590	COG1263	PTS System
B4U62_04590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U62_04595	COG1132	(ABC) transporter
B4U62_04600	COG1132	(ABC) transporter
B4U62_04605	COG2259	Doxx family
B4U62_04610	COG2514	catechol 2,3-dioxygenase activity
B4U62_04615	COG4977	sequence-specific DNA binding
B4U62_04615	COG1917	Cupin 2, conserved barrel domain protein
B4U62_04620	COG2814	Major facilitator Superfamily
B4U62_04625	COG1082	Xylose isomerase domain protein TIM barrel
B4U62_04630	COG0673	inositol 2-dehydrogenase activity
B4U62_04635	COG4585	Histidine kinase
B4U62_04640	COG2197	response regulator
B4U62_04645	COG1131	(ABC) transporter
B4U62_04650	COG0842	Transport permease protein
B4U62_04650	COG1511	domain protein
B4U62_04655	COG0842	Transport permease protein
B4U62_04660	COG1695	Transcriptional regulator
B4U62_04665	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B4U62_04670	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
B4U62_04675	COG1309	transcriptional regulator
B4U62_04680	COG2814	Major facilitator Superfamily
B4U62_04685	COG2318	DinB family
B4U62_04690	COG2814	Major facilitator Superfamily
B4U62_04695	COG1846	Transcriptional regulator
B4U62_04700	COG0392	lysyltransferase activity
B4U62_04700	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B4U62_04705	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4U62_04710	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U62_04715	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U62_04720	COG0384	phenazine biosynthesis protein PhzF
B4U62_04725	COG0778	Nitroreductase
B4U62_04740	COG1090	epimerase
B4U62_04745	COG2137	regulation of response to DNA damage stimulus
B4U62_04755	COG2814	Major facilitator Superfamily
B4U62_04770	COG3103	Sh3 type 3 domain protein
B4U62_04775	COG5658	integral membrane protein
B4U62_04780	COG0596	Alpha beta hydrolase
B4U62_04785	COG0463	Glycosyl transferase, family 2
B4U62_04790	COG4485	Bacterial membrane protein, YfhO
B4U62_04795	COG1988	membrane-bound metal-dependent
B4U62_04800	COG1194	a g-specific adenine glycosylase
B4U62_04810	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_04825	COG3557	Belongs to the UPF0374 family
B4U62_04830	COG1132	(ABC) transporter
B4U62_04835	COG4129	membrane
B4U62_04840	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B4U62_04845	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B4U62_04850	COG0735	belongs to the Fur family
B4U62_04960	COG4326	sporulation control protein
B4U62_04970	COG5577	PFAM Coat F domain
B4U62_04975	COG3340	Belongs to the peptidase S51 family
B4U62_04980	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B4U62_04985	COG0277	FAD linked oxidase domain protein
B4U62_04995	COG0753	catalase activity
B4U62_05000	COG1116	anion transmembrane transporter activity
B4U62_05005	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B4U62_05010	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B4U62_05015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U62_05025	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B4U62_05035	COG1476	TRANSCRIPTIONal
B4U62_05045	COG3382	B3 4 domain protein
B4U62_05050	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B4U62_05060	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B4U62_05065	COG0789	Transcriptional regulator
B4U62_05070	COG1664	Polymer-forming cytoskeletal
B4U62_05075	COG1664	Polymer-forming cytoskeletal
B4U62_05080	COG2766	serine protein kinase
B4U62_05085	COG2718	Belongs to the UPF0229 family
B4U62_05090	COG1846	Transcriptional regulator
B4U62_05095	COG1566	PFAM secretion protein HlyD family protein
B4U62_05100	COG2814	Major facilitator Superfamily
B4U62_05105	COG0655	NAD(P)H dehydrogenase (quinone) activity
B4U62_05125	COG1725	Transcriptional regulator
B4U62_05130	COG1131	(ABC) transporter
B4U62_05135	COG1131	(ABC) transporter
B4U62_05140	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B4U62_05145	COG1278	Cold shock
B4U62_05155	COG1464	Belongs to the NlpA lipoprotein family
B4U62_05160	COG3706	GGDEF domain
B4U62_05165	COG1823	symporter activity
B4U62_05185	COG5577	PFAM Coat F domain
B4U62_05190	COG1525	nuclease
B4U62_05190	COG0737	Belongs to the 5'-nucleotidase family
B4U62_05190	COG4085	toxin activity
B4U62_05195	COG3764	Sortase (surface protein transpeptidase)
B4U62_05200	COG0564	pseudouridine synthase activity
B4U62_05210	COG0517	IMP dehydrogenase activity
B4U62_05215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B4U62_05220	COG3153	acetyltransferase
B4U62_05220	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B4U62_05225	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B4U62_05230	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
B4U62_05235	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B4U62_05240	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B4U62_05245	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B4U62_05250	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B4U62_05255	COG4585	Histidine kinase
B4U62_05255	COG2203	Gaf domain
B4U62_05260	COG2197	response regulator
B4U62_05265	COG0431	NADPH-dependent FMN reductase
B4U62_05280	COG1388	LysM domain
B4U62_05280	COG0791	NLP P60 protein
B4U62_05285	COG1959	2 iron, 2 sulfur cluster binding
B4U62_05290	COG0668	transmembrane transport
B4U62_05295	COG2719	SpoVR family
B4U62_05300	COG1785	Belongs to the alkaline phosphatase family
B4U62_05305	COG1388	LysM domain
B4U62_05305	COG0791	NLP P60 protein
B4U62_05310	COG0583	DNA-binding transcription factor activity
B4U62_05315	COG0372	Belongs to the citrate synthase family
B4U62_05320	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_05325	COG0531	amino acid
B4U62_05330	COG0733	neurotransmitter:sodium symporter activity
B4U62_05335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4U62_05340	COG0456	acetyltransferase
B4U62_05355	COG1595	DNA-templated transcription, initiation
B4U62_05360	COG0667	Aldo Keto reductase
B4U62_05365	COG0204	Acyl-transferase
B4U62_05370	COG1253	flavin adenine dinucleotide binding
B4U62_05375	COG0789	Transcriptional regulator
B4U62_05380	COG0436	Aminotransferase
B4U62_05385	COG1253	flavin adenine dinucleotide binding
B4U62_05390	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B4U62_05395	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B4U62_05400	COG0584	glycerophosphoryl diester phosphodiesterase
B4U62_05410	COG0668	transmembrane transport
B4U62_05415	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B4U62_05420	COG0726	polysaccharide deacetylase
B4U62_05425	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4U62_05430	COG1757	Na H antiporter
B4U62_05435	COG0589	response to stress
B4U62_05445	COG1132	(ABC) transporter
B4U62_05455	COG0702	epimerase
B4U62_05475	COG0189	ligase activity
B4U62_05480	COG0189	ligase activity
B4U62_05485	COG4399	Belongs to the UPF0754 family
B4U62_05490	COG3679	Belongs to the UPF0342 family
B4U62_05495	COG4335	DNA alkylation repair
B4U62_05500	COG0561	phosphatase activity
B4U62_05505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B4U62_05510	COG0475	glutathione-regulated potassium exporter activity
B4U62_05515	COG0490	domain, Protein
B4U62_05525	COG1024	Enoyl-CoA hydratase
B4U62_05535	COG4152	abc transporter atp-binding protein
B4U62_05540	COG1668	transmembrane transport
B4U62_05545	COG0420	3'-5' exonuclease activity
B4U62_05550	COG4717	serine-type aminopeptidase activity
B4U62_05555	COG3481	metal-dependent phosphohydrolase, HD sub domain
B4U62_05565	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B4U62_05595	COG1846	Transcriptional regulator
B4U62_05600	COG4980	gas vesicle protein
B4U62_05615	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B4U62_05620	COG0537	adenosine 5'-monophosphoramidase activity
B4U62_05625	COG1131	(ABC) transporter
B4U62_05630	COG4473	ABC transporter
B4U62_05640	COG1473	amidohydrolase
B4U62_05645	COG3069	C4-dicarboxylate transmembrane transporter activity
B4U62_05655	COG2329	Antibiotic biosynthesis monooxygenase
B4U62_05660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4U62_05665	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B4U62_05680	COG1309	transcriptional regulator
B4U62_05685	COG1511	domain protein
B4U62_05690	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4U62_05695	COG4377	Putative membrane peptidase family (DUF2324)
B4U62_05705	COG1363	Peptidase, m42
B4U62_05710	COG4405	Protein conserved in bacteria
B4U62_05715	COG1301	dicarboxylic acid transport
B4U62_05725	COG1234	tRNA 3'-trailer cleavage
B4U62_05730	COG0095	Lipoate-protein ligase
B4U62_05735	COG0702	epimerase
B4U62_05740	COG0318	PFAM AMP-dependent synthetase and ligase
B4U62_05750	COG0501	Belongs to the peptidase M48B family
B4U62_05755	COG1404	Belongs to the peptidase S8 family
B4U62_05760	COG0456	acetyltransferase
B4U62_05765	COG0604	alcohol dehydrogenase
B4U62_05770	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B4U62_05775	COG0406	alpha-ribazole phosphatase activity
B4U62_05780	COG0183	Belongs to the thiolase family
B4U62_05785	COG0318	PFAM AMP-dependent synthetase and ligase
B4U62_05790	COG1268	BioY protein
B4U62_05795	COG0840	transmembrane signaling receptor activity
B4U62_05800	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4U62_05800	COG0723	plastoquinol--plastocyanin reductase activity
B4U62_05805	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_05815	COG4903	ComK protein
B4U62_05820	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_05830	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4U62_05845	COG0398	Pfam SNARE associated Golgi protein
B4U62_05850	COG0681	Belongs to the peptidase S26 family
B4U62_05855	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B4U62_05860	COG1846	Transcriptional regulator
B4U62_05865	COG0738	Major facilitator superfamily
B4U62_05870	COG0673	inositol 2-dehydrogenase activity
B4U62_05875	COG0561	phosphatase activity
B4U62_05880	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B4U62_05885	COG1609	Transcriptional regulator
B4U62_05890	COG3180	Ammonia monooxygenase
B4U62_05895	COG0477	Major facilitator Superfamily
B4U62_05895	COG2814	Major facilitator Superfamily
B4U62_05900	COG4533	DNA binding
B4U62_05910	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
B4U62_05915	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
B4U62_05920	COG1074	ATP-dependent DNA helicase activity
B4U62_05925	COG0420	3'-5' exonuclease activity
B4U62_05930	COG0419	ATPase involved in DNA repair
B4U62_05935	COG1403	HNH endonuclease
B4U62_05975	COG5337	Spore coat protein CotH
B4U62_05980	COG0179	Fumarylacetoacetate (FAA) hydrolase
B4U62_05990	COG1404	Belongs to the peptidase S8 family
B4U62_06000	COG0367	asparagine synthase
B4U62_06005	COG2318	DinB family
B4U62_06010	COG1562	ergosterol biosynthetic process
B4U62_06015	COG0534	Mate efflux family protein
B4U62_06020	COG2207	Transcriptional regulator
B4U62_06020	COG1917	Cupin 2, conserved barrel domain protein
B4U62_06025	COG1609	Transcriptional regulator
B4U62_06030	COG0673	inositol 2-dehydrogenase activity
B4U62_06035	COG2318	DinB family
B4U62_06040	COG1279	arginine transmembrane transporter activity
B4U62_06045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B4U62_06050	COG1357	PFAM Pentapeptide repeats (8 copies)
B4U62_06055	COG2267	carboxylic ester hydrolase activity
B4U62_06060	COG0529	Catalyzes the synthesis of activated sulfate
B4U62_06065	COG2046	Belongs to the sulfate adenylyltransferase family
B4U62_06070	COG0175	sulfate reduction
B4U62_06075	COG2045	Belongs to the ComB family
B4U62_06080	COG1809	phosphosulfolactate synthase activity
B4U62_06085	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4U62_06090	COG4948	Mandelate Racemase Muconate Lactonizing
B4U62_06095	COG2814	Major facilitator Superfamily
B4U62_06100	COG0454	-acetyltransferase
B4U62_06105	COG2153	protein acetylation
B4U62_06110	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B4U62_06110	COG0646	methionine synthase
B4U62_06115	COG1666	GTP binding
B4U62_06120	COG2996	Protein conserved in bacteria
B4U62_06140	COG1695	Transcriptional regulator
B4U62_06155	COG3227	Zinc metalloprotease (Elastase)
B4U62_06160	COG1307	EDD domain protein, DegV family
B4U62_06165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4U62_06180	COG0561	phosphatase activity
B4U62_06185	COG1073	alpha beta
B4U62_06190	COG2151	metal-sulfur cluster biosynthetic enzyme
B4U62_06200	COG0277	FAD linked oxidase domain protein
B4U62_06205	COG2271	Major facilitator Superfamily
B4U62_06210	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B4U62_06225	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B4U62_06230	COG0505	Belongs to the CarA family
B4U62_06235	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B4U62_06240	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B4U62_06255	COG2267	carboxylic ester hydrolase activity
B4U62_06265	COG1744	ABC transporter substrate-binding protein PnrA-like
B4U62_06280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4U62_06285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B4U62_06290	COG5504	Zn-dependent protease
B4U62_06295	COG0444	Belongs to the ABC transporter superfamily
B4U62_06300	COG4608	Belongs to the ABC transporter superfamily
B4U62_06310	COG0601	transmembrane transport
B4U62_06315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4U62_06325	COG0180	Tryptophanyl-tRNA synthetase
B4U62_06330	COG4166	transmembrane transport
B4U62_06335	COG0601	transmembrane transport
B4U62_06340	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4U62_06345	COG0444	Belongs to the ABC transporter superfamily
B4U62_06350	COG4608	Belongs to the ABC transporter superfamily
B4U62_06355	COG2814	Major facilitator Superfamily
B4U62_06360	COG0456	acetyltransferase
B4U62_06365	COG1393	Belongs to the ArsC family
B4U62_06370	COG0861	Integral membrane protein TerC family
B4U62_06375	COG4862	establishment of competence for transformation
B4U62_06380	COG4469	Competence protein
B4U62_06385	COG1164	Oligoendopeptidase f
B4U62_06405	COG2346	COG2346, Truncated hemoglobins
B4U62_06410	COG0741	lytic transglycosylase activity
B4U62_06415	COG4116	CYTH
B4U62_06425	COG2357	RelA SpoT domain protein
B4U62_06430	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B4U62_06435	COG0564	pseudouridine synthase activity
B4U62_06440	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B4U62_06445	COG0569	domain protein
B4U62_06445	COG0475	glutathione-regulated potassium exporter activity
B4U62_06450	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B4U62_06455	COG0352	thiamine-phosphate diphosphorylase activity
B4U62_06460	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4U62_06465	COG2104	thiamine diphosphate biosynthetic process
B4U62_06470	COG2022	thiamine diphosphate biosynthetic process
B4U62_06475	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B4U62_06480	COG0351	phosphomethylpyrimidine kinase
B4U62_06485	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B4U62_06540	COG0210	DNA helicase
B4U62_06550	COG2153	protein acetylation
B4U62_06555	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B4U62_06560	COG2382	esterase
B4U62_06565	COG0626	cystathionine gamma-synthase activity
B4U62_06570	COG0626	cystathionine gamma-synthase activity
B4U62_06575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U62_06580	COG5505	Protein of unknown function (DUF819)
B4U62_06615	COG3677	Transposase
B4U62_06630	COG5484	DNA packaging
B4U62_06635	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
B4U62_06640	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_06650	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4U62_06650	COG3711	transcriptional antiterminator
B4U62_06660	COG1482	cell wall glycoprotein biosynthetic process
B4U62_06670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U62_06680	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B4U62_06700	COG0109	protoheme IX farnesyltransferase activity
B4U62_06710	COG0726	polysaccharide deacetylase
B4U62_06725	COG5504	Zn-dependent protease
B4U62_06730	COG2205	protein histidine kinase activity
B4U62_06740	COG3383	formate dehydrogenase (NAD+) activity
B4U62_06745	COG2427	Protein of unknown function (DUF1641)
B4U62_06755	COG1051	belongs to the nudix hydrolase family
B4U62_06765	COG2124	cytochrome p450
B4U62_06770	COG1819	glycosyl
B4U62_06780	COG1587	Uroporphyrinogen-III synthase
B4U62_06785	COG0390	transport system, permease component
B4U62_06790	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B4U62_06795	COG0697	spore germination
B4U62_06800	COG4297	protein containing double-stranded beta helix domain
B4U62_06810	COG1252	NADH dehydrogenase
B4U62_06815	COG1904	glucuronate isomerase
B4U62_06820	COG2211	Major facilitator Superfamily
B4U62_06825	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B4U62_06830	COG1063	alcohol dehydrogenase
B4U62_06835	COG1312	Catalyzes the dehydration of D-mannonate
B4U62_06840	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_06845	COG2271	Major facilitator Superfamily
B4U62_06850	COG1609	Transcriptional regulator
B4U62_06860	COG2721	sulfolactate sulfo-lyase activity
B4U62_06865	COG0730	response to heat
B4U62_06870	COG2318	DinB family
B4U62_06875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B4U62_06880	COG0457	Tetratricopeptide repeat
B4U62_06890	COG2350	Protein conserved in bacteria
B4U62_06895	COG1388	LysM domain
B4U62_06895	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4U62_06895	COG3409	Peptidoglycan-binding domain 1 protein
B4U62_06905	COG4195	phage-related replication protein
B4U62_06910	COG3546	catalase activity
B4U62_06915	COG2856	Zn peptidase
B4U62_06920	COG1396	sequence-specific DNA binding
B4U62_06930	COG1522	sequence-specific DNA binding
B4U62_06935	COG1484	DNA-dependent DNA replication
B4U62_06955	COG1595	DNA-templated transcription, initiation
B4U62_06960	COG3728	DNA packaging
B4U62_06960	COG5484	DNA packaging
B4U62_06965	COG1783	phage Terminase large subunit
B4U62_06975	COG0338	D12 class N6 adenine-specific DNA methyltransferase
B4U62_06980	COG4653	Phage capsid family
B4U62_07030	COG3953	SLT domain
B4U62_07030	COG5412	phage tail tape measure protein
B4U62_07035	COG1652	LysM domain
B4U62_07040	COG4193	domain, Protein
B4U62_07050	COG3628	GPW Gp25 family protein
B4U62_07055	COG3299	homolog of phage Mu protein gp47
B4U62_07060	COG3778	Protein conserved in bacteria
B4U62_07100	COG3409	Peptidoglycan-binding domain 1 protein
B4U62_07100	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4U62_07115	COG0306	phosphate transporter
B4U62_07120	COG1392	Phosphate transport regulator
B4U62_07125	COG0531	amino acid
B4U62_07130	COG0346	lactoylglutathione lyase activity
B4U62_07135	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B4U62_07140	COG0463	Glycosyl transferase, family 2
B4U62_07145	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4U62_07150	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4U62_07155	COG2362	D-Aminopeptidase
B4U62_07160	COG0601	transmembrane transport
B4U62_07165	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B4U62_07170	COG0444	Belongs to the ABC transporter superfamily
B4U62_07175	COG4166	transmembrane transport
B4U62_07180	COG1619	proteins homologs of microcin C7 resistance protein MccF
B4U62_07185	COG4948	Mandelate Racemase Muconate Lactonizing
B4U62_07190	COG0791	NLP P60 protein
B4U62_07195	COG4608	Belongs to the ABC transporter superfamily
B4U62_07200	COG2706	6-phosphogluconolactonase activity
B4U62_07205	COG1834	amidinotransferase
B4U62_07210	COG1607	acyl-coa hydrolase
B4U62_07215	COG1017	nitric oxide dioxygenase activity
B4U62_07215	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B4U62_07225	COG2323	membrane
B4U62_07230	COG2318	DinB family
B4U62_07235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U62_07240	COG2076	Multidrug Resistance protein
B4U62_07245	COG2076	Multidrug Resistance protein
B4U62_07250	COG0788	formyltetrahydrofolate deformylase activity
B4U62_07255	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B4U62_07260	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B4U62_07265	COG1764	response to oxidative stress
B4U62_07270	COG1846	Transcriptional regulator
B4U62_07275	COG1764	response to oxidative stress
B4U62_07285	COG0590	tRNA wobble adenosine to inosine editing
B4U62_07290	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B4U62_07295	COG1404	Belongs to the peptidase S8 family
B4U62_07300	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U62_07305	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B4U62_07310	COG1122	ATPase activity
B4U62_07315	COG4721	ABC-type cobalt transport system, permease component
B4U62_07325	COG0745	RESPONSE REGULATOR receiver
B4U62_07330	COG5002	protein histidine kinase activity
B4U62_07330	COG3850	Histidine kinase
B4U62_07335	COG3212	peptidase
B4U62_07340	COG3212	peptidase
B4U62_07355	COG2239	Acts as a magnesium transporter
B4U62_07360	COG0789	Transcriptional regulator
B4U62_07375	COG1846	Transcriptional regulator
B4U62_07380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B4U62_07385	COG0726	polysaccharide deacetylase
B4U62_07390	COG1408	metallophosphoesterase
B4U62_07400	COG0463	Glycosyl transferase, family 2
B4U62_07405	COG1793	dna ligase
B4U62_07405	COG3285	dna ligase
B4U62_07410	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B4U62_07415	COG5001	Diguanylate cyclase
B4U62_07415	COG3300	MHYT domain
B4U62_07420	COG0586	Pfam SNARE associated Golgi protein
B4U62_07425	COG0861	Integral membrane protein TerC family
B4U62_07430	COG1191	sigma factor activity
B4U62_07450	COG0501	Belongs to the peptidase M48B family
B4U62_07455	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B4U62_07470	COG3594	Acyltransferase
B4U62_07475	COG5002	protein histidine kinase activity
B4U62_07480	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B4U62_07485	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B4U62_07490	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
B4U62_07495	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B4U62_07500	COG0436	Aminotransferase
B4U62_07505	COG1850	ribulose-bisphosphate carboxylase activity
B4U62_07510	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
B4U62_07515	COG0235	Class ii aldolase
B4U62_07520	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
B4U62_07525	COG3339	Conserved Protein
B4U62_07540	COG3852	Histidine kinase
B4U62_07545	COG1846	Transcriptional regulator
B4U62_07550	COG1360	Flagellar Motor Protein
B4U62_07555	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B4U62_07560	COG0542	response to heat
B4U62_07565	COG3949	Membrane
B4U62_07570	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B4U62_07575	COG0720	synthase
B4U62_07580	COG0602	queuosine metabolic process
B4U62_07585	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B4U62_07590	COG1733	regulation of RNA biosynthetic process
B4U62_07595	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_07600	COG4641	Protein conserved in bacteria
B4U62_07600	COG1388	LysM domain
B4U62_07605	COG1388	LysM domain
B4U62_07610	COG3858	chitin binding
B4U62_07615	COG3858	chitin binding
B4U62_07625	COG4873	Protein conserved in bacteria
B4U62_07635	COG3773	Cell wall hydrolase
B4U62_07640	COG2244	polysaccharide biosynthetic process
B4U62_07645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U62_07650	COG2217	Heavy metal translocating P-type atpase
B4U62_07660	COG0006	proline dipeptidase activity
B4U62_07665	COG1609	Transcriptional regulator
B4U62_07670	COG3711	transcriptional antiterminator
B4U62_07675	COG1263	PTS System
B4U62_07675	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U62_07675	COG2190	(PTS) system
B4U62_07680	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4U62_07685	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B4U62_07695	COG1533	DNA photolyase activity
B4U62_07700	COG0456	acetyltransferase
B4U62_07705	COG0840	transmembrane signaling receptor activity
B4U62_07710	COG2084	Dehydrogenase
B4U62_07715	COG2340	Cysteine-rich secretory protein family
B4U62_07720	COG0768	penicillin binding
B4U62_07725	COG4191	Histidine kinase
B4U62_07730	COG0436	Aminotransferase
B4U62_07740	COG0835	chemotaxis
B4U62_07740	COG0784	Response regulator, receiver
B4U62_07750	COG2814	Major facilitator Superfamily
B4U62_07755	COG1376	ErfK ybiS ycfS ynhG family protein
B4U62_07760	COG1408	metallophosphoesterase
B4U62_07765	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_07770	COG3409	Peptidoglycan-binding domain 1 protein
B4U62_07775	COG3409	Peptidoglycan-binding domain 1 protein
B4U62_07785	COG2200	EAL domain
B4U62_07790	COG4703	Protein of unknown function (DUF1797)
B4U62_07795	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
B4U62_07805	COG0517	IMP dehydrogenase activity
B4U62_07810	COG0583	DNA-binding transcription factor activity
B4U62_07815	COG0716	FMN binding
B4U62_07825	COG0716	FMN binding
B4U62_07830	COG2171	N-acyltransferase activity
B4U62_07835	COG1473	amidohydrolase
B4U62_07845	COG0668	transmembrane transport
B4U62_07850	COG0450	alkyl hydroperoxide reductase
B4U62_07855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U62_07870	COG0746	molybdenum cofactor guanylyltransferase activity
B4U62_07875	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B4U62_07880	COG0303	'Molybdopterin
B4U62_07885	COG1763	Mo-molybdopterin cofactor biosynthetic process
B4U62_07890	COG0314	molybdopterin synthase activity
B4U62_07895	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B4U62_07900	COG1132	(ABC) transporter
B4U62_07905	COG1132	(ABC) transporter
B4U62_07915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B4U62_07920	COG1136	(ABC) transporter
B4U62_07925	COG0577	efflux transmembrane transporter activity
B4U62_07930	COG1349	DNA-binding transcription factor activity
B4U62_07935	COG1105	Belongs to the carbohydrate kinase PfkB family
B4U62_07940	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4U62_07940	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4U62_07940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B4U62_07945	COG0681	Belongs to the peptidase S26 family
B4U62_07955	COG0488	(ABC) transporter
B4U62_07960	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B4U62_07965	COG2309	aminopeptidase activity
B4U62_07975	COG1077	Cell shape determining protein MreB Mrl
B4U62_07980	COG2002	toxin-antitoxin pair type II binding
B4U62_07985	COG3852	Histidine kinase
B4U62_07990	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
B4U62_07990	COG2105	PFAM AIG2 family protein
B4U62_07995	COG0569	domain protein
B4U62_08000	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B4U62_08005	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B4U62_08015	COG0561	phosphatase activity
B4U62_08020	COG0242	peptide deformylase activity
B4U62_08030	COG0497	DNA recombination
B4U62_08035	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B4U62_08040	COG0022	dehydrogenase e1 component
B4U62_08045	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4U62_08050	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B4U62_08055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U62_08065	COG1982	Orn Lys Arg decarboxylase major
B4U62_08070	COG4476	Belongs to the UPF0223 family
B4U62_08075	COG4493	Belongs to the UPF0637 family
B4U62_08085	COG0483	inositol monophosphate 1-phosphatase activity
B4U62_08095	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B4U62_08115	COG1595	DNA-templated transcription, initiation
B4U62_08145	COG4896	Protein conserved in bacteria
B4U62_08155	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B4U62_08160	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B4U62_08165	COG2066	Belongs to the glutaminase family
B4U62_08170	COG4838	Belongs to the UPF0358 family
B4U62_08175	COG0772	Belongs to the SEDS family
B4U62_08180	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
B4U62_08185	COG1612	heme a metabolic process
B4U62_08190	COG0109	protoheme IX farnesyltransferase activity
B4U62_08195	COG2010	Cytochrome c
B4U62_08195	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B4U62_08200	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B4U62_08205	COG1845	cytochrome c oxidase, subunit III
B4U62_08210	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B4U62_08215	COG3336	cytochrome c oxidase
B4U62_08225	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
B4U62_08230	COG2340	Cysteine-rich secretory protein family
B4U62_08245	COG3679	Belongs to the UPF0342 family
B4U62_08250	COG4471	UPF0298 protein
B4U62_08255	COG0742	ribosomal rna small subunit methyltransferase
B4U62_08260	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B4U62_08265	COG3314	Sporulation integral membrane protein YlbJ
B4U62_08270	COG1752	Esterase of the alpha-beta hydrolase superfamily
B4U62_08275	COG3480	Lon protease (S16) C-terminal proteolytic domain
B4U62_08280	COG1323	Belongs to the UPF0348 family
B4U62_08290	COG1399	metal-binding, possibly nucleic acid-binding protein
B4U62_08295	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B4U62_08305	COG0454	-acetyltransferase
B4U62_08310	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B4U62_08315	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
B4U62_08320	COG2001	Belongs to the MraZ family
B4U62_08325	COG0275	rRNA processing
B4U62_08330	COG4839	cell division protein FtsL
B4U62_08340	COG0768	penicillin binding
B4U62_08345	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B4U62_08350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B4U62_08355	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B4U62_08360	COG0772	Belongs to the SEDS family
B4U62_08365	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B4U62_08370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B4U62_08375	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B4U62_08380	COG3879	Bacterial protein of unknown function (DUF881)
B4U62_08385	COG3879	Bacterial protein of unknown function (DUF881)
B4U62_08390	COG3856	small basic protein
B4U62_08395	COG0849	cell division
B4U62_08400	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B4U62_08405	COG1404	Belongs to the peptidase S8 family
B4U62_08405	COG4412	M6 family metalloprotease domain protein
B4U62_08415	COG1191	sigma factor activity
B4U62_08420	COG1191	sigma factor activity
B4U62_08425	COG1119	ATPase activity
B4U62_08430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4U62_08435	COG1873	PFAM PRC-barrel domain
B4U62_08445	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B4U62_08450	COG1799	cell septum assembly
B4U62_08455	COG0762	integral membrane protein
B4U62_08460	COG2302	S4 RNA-binding domain
B4U62_08465	COG3599	regulation of cell shape
B4U62_08470	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B4U62_08475	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B4U62_08480	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B4U62_08485	COG0564	pseudouridine synthase activity
B4U62_08490	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B4U62_08495	COG2233	PERMEase
B4U62_08500	COG0540	Belongs to the ATCase OTCase family
B4U62_08505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B4U62_08510	COG0505	Belongs to the CarA family
B4U62_08515	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B4U62_08520	COG0543	2 iron, 2 sulfur cluster binding
B4U62_08525	COG0167	dihydroorotate dehydrogenase activity
B4U62_08530	COG0284	orotidine-5'-phosphate decarboxylase activity
B4U62_08535	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B4U62_08540	COG0175	sulfate reduction
B4U62_08545	COG0306	phosphate transporter
B4U62_08550	COG2046	Belongs to the sulfate adenylyltransferase family
B4U62_08555	COG0529	Catalyzes the synthesis of activated sulfate
B4U62_08560	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B4U62_08565	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
B4U62_08570	COG1648	precorrin-2 dehydrogenase activity
B4U62_08580	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B4U62_08585	COG1561	YicC-like family, N-terminal region
B4U62_08590	COG2052	Domain of unknown function (DUF370)
B4U62_08595	COG0194	GDP metabolic process
B4U62_08600	COG1758	RNA polymerase activity
B4U62_08605	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B4U62_08610	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B4U62_08615	COG0242	peptide deformylase activity
B4U62_08620	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B4U62_08625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B4U62_08625	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B4U62_08630	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B4U62_08635	COG0631	protein serine/threonine phosphatase activity
B4U62_08640	COG0515	serine threonine protein kinase
B4U62_08640	COG2815	serine threonine protein kinase
B4U62_08645	COG1162	GTPase activity
B4U62_08650	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B4U62_08655	COG1564	THIamine pyrophosphokinase
B4U62_08665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B4U62_08670	COG1302	Protein conserved in bacteria
B4U62_08675	COG1461	Dihydroxyacetone kinase
B4U62_08680	COG1760	l-serine dehydratase
B4U62_08685	COG1760	l-serine dehydratase
B4U62_08690	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B4U62_08695	COG1349	DNA-binding transcription factor activity
B4U62_08695	COG2050	protein possibly involved in aromatic compounds catabolism
B4U62_08700	COG0416	fatty acid biosynthetic process
B4U62_08705	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B4U62_08710	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_08715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4U62_08720	COG0571	ribonuclease III activity
B4U62_08725	COG1196	nuclear chromosome segregation
B4U62_08730	COG0552	protein localization to endoplasmic reticulum
B4U62_08740	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
B4U62_08745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B4U62_08750	COG0228	four-way junction DNA binding
B4U62_08755	COG1837	Belongs to the UPF0109 family
B4U62_08765	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B4U62_08770	COG0336	Belongs to the RNA methyltransferase TrmD family
B4U62_08775	COG0335	large ribosomal subunit rRNA binding
B4U62_08780	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B4U62_08785	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B4U62_08795	COG2257	FlhB HrpN YscU SpaS Family
B4U62_08800	COG0045	succinate-CoA ligase (ADP-forming) activity
B4U62_08805	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B4U62_08810	COG0758	DNA mediated transformation
B4U62_08815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B4U62_08820	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
B4U62_08825	COG4974	Belongs to the 'phage' integrase family
B4U62_08830	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B4U62_08835	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B4U62_08840	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
B4U62_08845	COG1815	bacterial-type flagellum-dependent cell motility
B4U62_08850	COG1558	bacterial-type flagellum-dependent cell motility
B4U62_08855	COG1677	Flagellar hook-basal body complex protein FliE
B4U62_08860	COG1766	The M ring may be actively involved in energy transduction
B4U62_08865	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B4U62_08870	COG1317	bacterial-type flagellum organization
B4U62_08875	COG1157	protein secretion by the type III secretion system
B4U62_08880	COG2882	bacterial-type flagellum organization
B4U62_08885	COG3334	PFAM MgtE intracellular
B4U62_08890	COG3144	bacterial-type flagellum assembly
B4U62_08895	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B4U62_08900	COG4786	Flagellar basal body rod
B4U62_08905	COG1582	Flagellar protein (FlbD)
B4U62_08910	COG1580	Controls the rotational direction of flagella during chemotaxis
B4U62_08915	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B4U62_08920	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B4U62_08920	COG1776	CheC inhibitor of MCP methylation
B4U62_08925	COG2201	protein-glutamate methylesterase activity
B4U62_08930	COG3190	flagellar
B4U62_08935	COG1338	Plays a role in the flagellum-specific transport system
B4U62_08940	COG1987	bacterial-type flagellum assembly
B4U62_08945	COG1684	flagellar biosynthetic protein fliR
B4U62_08950	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B4U62_08955	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B4U62_08960	COG1419	protein localization to endoplasmic reticulum
B4U62_08965	COG0455	bacterial-type flagellum organization
B4U62_08970	COG2201	protein-glutamate methylesterase activity
B4U62_08975	COG0643	Histidine kinase
B4U62_08975	COG2198	Histidine kinase
B4U62_08980	COG0835	chemotaxis
B4U62_08985	COG1776	CheC inhibitor of MCP methylation
B4U62_08990	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B4U62_08995	COG1191	sigma factor activity
B4U62_09005	COG0052	Belongs to the universal ribosomal protein uS2 family
B4U62_09010	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B4U62_09015	COG0528	UMP kinase activity
B4U62_09020	COG0233	cytoplasmic translational termination
B4U62_09025	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B4U62_09030	COG4589	Belongs to the CDS family
B4U62_09035	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B4U62_09040	COG0750	zinc metalloprotease
B4U62_09045	COG0442	prolyl-tRNA aminoacylation
B4U62_09050	COG2176	DNA-directed DNA polymerase activity
B4U62_09055	COG0779	Required for maturation of 30S ribosomal subunits
B4U62_09060	COG0195	Participates in both transcription termination and antitermination
B4U62_09065	COG2740	Nucleic-acid-binding protein implicated in transcription termination
B4U62_09070	COG1358	cellular component organization or biogenesis
B4U62_09075	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B4U62_09080	COG1550	Protein conserved in bacteria
B4U62_09085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B4U62_09090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B4U62_09095	COG0196	riboflavin kinase activity
B4U62_09100	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B4U62_09105	COG1185	polyribonucleotide nucleotidyltransferase activity
B4U62_09110	COG0726	polysaccharide deacetylase
B4U62_09115	COG0612	Peptidase, M16
B4U62_09120	COG1873	PFAM PRC-barrel domain
B4U62_09125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B4U62_09130	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B4U62_09135	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B4U62_09140	COG0527	aspartate kinase activity
B4U62_09145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B4U62_09150	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B4U62_09155	COG0740	serine-type endopeptidase activity
B4U62_09165	COG4980	gas vesicle protein
B4U62_09165	COG1674	ftsk spoiiie
B4U62_09170	COG2188	Transcriptional regulator
B4U62_09175	COG2814	Major facilitator Superfamily
B4U62_09180	COG0612	Peptidase, M16
B4U62_09185	COG0612	Peptidase, M16
B4U62_09190	COG0300	oxidoreductase activity
B4U62_09205	COG1426	Protein conserved in bacteria
B4U62_09210	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B4U62_09215	COG1546	Belongs to the CinA family
B4U62_09215	COG1058	Belongs to the CinA family
B4U62_09220	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B4U62_09225	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B4U62_09230	COG1418	mRNA catabolic process
B4U62_09235	COG1692	metallophosphoesterase
B4U62_09240	COG2359	stage V sporulation protein S
B4U62_09245	COG1063	alcohol dehydrogenase
B4U62_09250	COG0156	8-amino-7-oxononanoate synthase activity
B4U62_09255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B4U62_09260	COG4550	Control of competence regulator ComK, YlbF/YmcA
B4U62_09270	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B4U62_09275	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B4U62_09290	COG3226	Transcriptional regulator
B4U62_09295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4U62_09305	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B4U62_09310	COG3321	synthase
B4U62_09315	COG2070	2-Nitropropane dioxygenase
B4U62_09315	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B4U62_09320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4U62_09325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B4U62_09330	COG3425	synthase
B4U62_09335	COG1024	Enoyl-CoA hydratase
B4U62_09340	COG1024	Enoyl-CoA hydratase
B4U62_09345	COG0300	oxidoreductase activity
B4U62_09345	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_09345	COG3321	synthase
B4U62_09345	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U62_09345	COG0318	PFAM AMP-dependent synthetase and ligase
B4U62_09350	COG3321	synthase
B4U62_09350	COG4221	oxidoreductase activity
B4U62_09350	COG0300	oxidoreductase activity
B4U62_09350	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4U62_09355	COG3321	synthase
B4U62_09355	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4U62_09355	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B4U62_09355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U62_09355	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_09360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U62_09360	COG3321	synthase
B4U62_09360	COG4221	oxidoreductase activity
B4U62_09360	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_09365	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
B4U62_09365	COG3321	synthase
B4U62_09365	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B4U62_09365	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4U62_09370	COG2124	cytochrome p450
B4U62_09380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4U62_09385	COG1404	Belongs to the peptidase S8 family
B4U62_09390	COG4195	phage-related replication protein
B4U62_09395	COG1764	response to oxidative stress
B4U62_09400	COG2076	Multidrug Resistance protein
B4U62_09405	COG2076	Multidrug Resistance protein
B4U62_09420	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B4U62_09425	COG1923	regulation of RNA biosynthetic process
B4U62_09440	COG1780	Probably involved in ribonucleotide reductase function
B4U62_09445	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4U62_09450	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4U62_09455	COG4112	unkown
B4U62_09460	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U62_09470	COG0464	growth
B4U62_09475	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B4U62_09480	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
B4U62_09485	COG0789	Transcriptional regulator
B4U62_09490	COG0174	glutamine synthetase
B4U62_09510	COG4282	regulation of fungal-type cell wall biogenesis
B4U62_09520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U62_09545	COG0135	phosphoribosylanthranilate isomerase activity
B4U62_09550	COG2211	Major facilitator Superfamily
B4U62_09555	COG3507	Belongs to the glycosyl hydrolase 43 family
B4U62_09560	COG1940	carbohydrate kinase activity
B4U62_09565	COG2115	Belongs to the xylose isomerase family
B4U62_09570	COG1070	Carbohydrate kinase
B4U62_09580	COG1525	nuclease
B4U62_09585	COG2814	Major facilitator Superfamily
B4U62_09590	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B4U62_09600	COG0756	dUTP diphosphatase activity
B4U62_09610	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B4U62_09635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B4U62_09645	COG3832	glyoxalase III activity
B4U62_09660	COG0697	spore germination
B4U62_09665	COG0531	amino acid
B4U62_09695	COG4195	phage-related replication protein
B4U62_09705	COG0346	lactoylglutathione lyase activity
B4U62_09715	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B4U62_09720	COG1388	LysM domain
B4U62_09725	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B4U62_09730	COG4224	UPF0291 protein
B4U62_09735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B4U62_09745	COG3763	UPF0154 protein
B4U62_09755	COG0785	Cytochrome C biogenesis protein
B4U62_09760	COG2201	protein-glutamate methylesterase activity
B4U62_09765	COG4846	Membrane protein involved in cytochrome C biogenesis
B4U62_09775	COG0071	Belongs to the small heat shock protein (HSP20) family
B4U62_09790	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B4U62_09795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U62_09815	COG0824	Thioesterase
B4U62_09825	COG4841	protein insertion into membrane
B4U62_09830	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B4U62_09835	COG1832	CoA-binding protein
B4U62_09840	COG0187	DNA topoisomerase II activity
B4U62_09845	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B4U62_09855	COG1115	amino acid carrier protein
B4U62_09860	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B4U62_09870	COG5520	Belongs to the glycosyl hydrolase 30 family
B4U62_09875	COG3507	Belongs to the glycosyl hydrolase 43 family
B4U62_09885	COG2246	polysaccharide biosynthetic process
B4U62_09890	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B4U62_09895	COG0586	Pfam SNARE associated Golgi protein
B4U62_09900	COG2404	hydrolase activity, acting on ester bonds
B4U62_09905	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B4U62_09910	COG1024	Enoyl-CoA hydratase
B4U62_09915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B4U62_09920	COG0511	ligase activity, forming carbon-carbon bonds
B4U62_09925	COG0439	Biotin carboxylase
B4U62_09930	COG0318	PFAM AMP-dependent synthetase and ligase
B4U62_09935	COG1960	acyl-CoA dehydrogenase activity
B4U62_09945	COG1649	PFAM Uncharacterised BCR, COG1649
B4U62_09955	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
B4U62_09955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U62_09960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U62_09965	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U62_09970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U62_09975	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U62_09980	COG2027	D-alanyl-D-alanine carboxypeptidase
B4U62_09985	COG2017	converts alpha-aldose to the beta-anomer
B4U62_09990	COG0534	Mate efflux family protein
B4U62_10005	COG0582	viral genome integration into host DNA
B4U62_10010	COG0166	Belongs to the GPI family
B4U62_10015	COG0405	Gamma-glutamyltransferase
B4U62_10020	COG0583	DNA-binding transcription factor activity
B4U62_10025	COG0604	alcohol dehydrogenase
B4U62_10030	COG0493	'glutamate synthase
B4U62_10035	COG0067	glutamate synthase
B4U62_10035	COG0069	glutamate synthase activity
B4U62_10035	COG0070	glutamate synthase
B4U62_10040	COG0583	DNA-binding transcription factor activity
B4U62_10045	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B4U62_10050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4U62_10060	COG0300	oxidoreductase activity
B4U62_10065	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
B4U62_10075	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U62_10080	COG2814	Major facilitator Superfamily
B4U62_10085	COG1070	Carbohydrate kinase
B4U62_10090	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B4U62_10095	COG0243	molybdopterin cofactor binding
B4U62_10120	COG0840	transmembrane signaling receptor activity
B4U62_10120	COG5278	phosphoserine phosphatase activity
B4U62_10125	COG2368	4-hydroxyphenylacetate
B4U62_10130	COG4305	rare lipoprotein A
B4U62_10135	COG3619	membrane
B4U62_10140	COG3866	Pectate lyase
B4U62_10145	COG2135	peptidase activity
B4U62_10155	COG2140	Oxalate decarboxylase
B4U62_10165	COG0456	acetyltransferase
B4U62_10185	COG2720	vancomycin resistance protein
B4U62_10195	COG3655	Transcriptional regulator
B4U62_10200	COG3739	integral membrane protein
B4U62_10205	COG0583	DNA-binding transcription factor activity
B4U62_10210	COG0697	spore germination
B4U62_10220	COG0693	protein deglycase activity
B4U62_10225	COG2367	Beta-lactamase
B4U62_10245	COG3848	Pyruvate phosphate dikinase
B4U62_10245	COG0574	Belongs to the PEP-utilizing enzyme family
B4U62_10250	COG0726	polysaccharide deacetylase
B4U62_10260	COG2314	TM2 domain
B4U62_10265	COG1396	sequence-specific DNA binding
B4U62_10280	COG2135	peptidase activity
B4U62_10315	COG0457	Tetratricopeptide repeat
B4U62_10340	COG5290	Psort location Cytoplasmic, score
B4U62_10360	COG5444	nuclease activity
B4U62_10365	COG4282	regulation of fungal-type cell wall biogenesis
B4U62_10370	COG1231	oxidoreductase activity
B4U62_10375	COG5434	Belongs to the glycosyl hydrolase 28 family
B4U62_10380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4U62_10385	COG2207	Transcriptional regulator
B4U62_10385	COG0662	Cupin 2, conserved barrel domain protein
B4U62_10390	COG0456	acetyltransferase
B4U62_10395	COG1309	transcriptional regulator
B4U62_10400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4U62_10405	COG3708	Transcriptional regulator
B4U62_10410	COG2378	regulation of single-species biofilm formation
B4U62_10420	COG0640	Transcriptional regulator
B4U62_10425	COG0741	lytic transglycosylase activity
B4U62_10430	COG2322	membrane
B4U62_10445	COG1619	proteins homologs of microcin C7 resistance protein MccF
B4U62_10450	COG3239	Fatty acid desaturase
B4U62_10455	COG4585	Histidine kinase
B4U62_10460	COG2197	response regulator
B4U62_10465	COG3584	3D domain protein
B4U62_10465	COG1388	LysM domain
B4U62_10470	COG0514	ATP-dependent DNA helicase (RecQ)
B4U62_10485	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B4U62_10490	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B4U62_10505	COG0071	Belongs to the small heat shock protein (HSP20) family
B4U62_10530	COG1012	belongs to the aldehyde dehydrogenase family
B4U62_10535	COG1657	PFAM Prenyltransferase squalene oxidase
B4U62_10540	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B4U62_10545	COG0733	neurotransmitter:sodium symporter activity
B4U62_10550	COG0385	Bile acid
B4U62_10555	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4U62_10560	COG0567	Dehydrogenase, E1 component
B4U62_10565	COG4548	von Willebrand factor, type A
B4U62_10570	COG0714	Associated with various cellular activities
B4U62_10575	COG2032	superoxide dismutase activity
B4U62_10580	COG1388	LysM domain
B4U62_10580	COG0791	NLP P60 protein
B4U62_10585	COG1819	glycosyl
B4U62_10590	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B4U62_10595	COG0534	Mate efflux family protein
B4U62_10600	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U62_10605	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B4U62_10610	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B4U62_10620	COG2962	Rard protein
B4U62_10635	COG2610	gluconate transmembrane transporter activity
B4U62_10640	COG1942	4-Oxalocrotonate Tautomerase
B4U62_10645	COG1733	regulation of RNA biosynthetic process
B4U62_10650	COG0778	Nitroreductase
B4U62_10655	COG0400	carboxylic ester hydrolase activity
B4U62_10660	COG0346	lactoylglutathione lyase activity
B4U62_10670	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4U62_10675	COG3409	Peptidoglycan-binding domain 1 protein
B4U62_10675	COG0793	Belongs to the peptidase S41A family
B4U62_10680	COG2226	methyltransferase
B4U62_10690	COG1876	peptidase activity
B4U62_10695	COG0813	purine-nucleoside phosphorylase activity
B4U62_10710	COG0671	phosphoesterase, PA-phosphatase related
B4U62_10735	COG4479	Belongs to the UPF0346 family
B4U62_10745	COG1509	lysine 2,3-aminomutase activity
B4U62_10750	COG0456	acetyltransferase
B4U62_10755	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4U62_10760	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B4U62_10765	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B4U62_10770	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B4U62_10780	COG0456	acetyltransferase
B4U62_10785	COG0463	Glycosyl transferase, family 2
B4U62_10800	COG4641	Protein conserved in bacteria
B4U62_10805	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
B4U62_10810	COG1086	Polysaccharide biosynthesis protein
B4U62_10820	COG3331	DNA recombination
B4U62_10875	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B4U62_10910	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
B4U62_10915	COG0756	dUTP diphosphatase activity
B4U62_10920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U62_10950	COG1780	Probably involved in ribonucleotide reductase function
B4U62_11040	COG0270	DNA (cytosine-5-)-methyltransferase activity
B4U62_11050	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
B4U62_11055	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B4U62_11080	COG3584	3D domain protein
B4U62_11085	COG0587	DNA-directed DNA polymerase activity
B4U62_11090	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B4U62_11095	COG0358	DNA primase activity
B4U62_11100	COG0305	Participates in initiation and elongation during chromosome replication
B4U62_11110	COG2887	Belongs to the helicase family. UvrD subfamily
B4U62_11140	COG5434	Belongs to the glycosyl hydrolase 28 family
B4U62_11140	COG3420	alginic acid biosynthetic process
B4U62_11145	COG4195	phage-related replication protein
B4U62_11160	COG2135	peptidase activity
B4U62_11165	COG1793	dna ligase
B4U62_11220	COG4474	Belongs to the UPF0398 family
B4U62_11230	COG1388	LysM domain
B4U62_11250	COG3646	Phage regulatory protein
B4U62_11250	COG3645	SOS response
B4U62_11305	COG3655	Transcriptional regulator
B4U62_11320	COG0582	viral genome integration into host DNA
B4U62_11400	COG3655	Transcriptional regulator
B4U62_11440	COG1395	domain, Protein
B4U62_11455	COG0776	regulation of translation
B4U62_11485	COG4373	Mu-like prophage FluMu protein gp28
B4U62_11585	COG0582	viral genome integration into host DNA
B4U62_11615	COG0741	lytic transglycosylase activity
B4U62_11615	COG1196	nuclear chromosome segregation
B4U62_11615	COG0739	heme binding
B4U62_11625	COG2433	Pfam Transposase IS66
B4U62_11635	COG5434	Belongs to the glycosyl hydrolase 28 family
B4U62_11635	COG4632	Exopolysaccharide biosynthesis protein
B4U62_11650	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4U62_11665	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B4U62_11670	COG0463	Glycosyl transferase, family 2
B4U62_11675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U62_11680	COG2274	protein secretion by the type I secretion system
B4U62_11680	COG3271	cysteine-type peptidase activity
B4U62_11695	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B4U62_11720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B4U62_11735	COG5444	nuclease activity
B4U62_11740	COG4282	regulation of fungal-type cell wall biogenesis
B4U62_11755	COG1525	nuclease
B4U62_11765	COG2746	aminoglycoside 3-N-acetyltransferase activity
B4U62_11780	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B4U62_11785	COG1086	Polysaccharide biosynthesis protein
B4U62_11790	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4U62_11795	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B4U62_11800	COG1846	Transcriptional regulator
B4U62_11805	COG0534	Mate efflux family protein
B4U62_11815	COG4698	Protein conserved in bacteria
B4U62_11820	COG2755	lipolytic protein G-D-S-L family
B4U62_11825	COG1999	signal sequence binding
B4U62_11835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B4U62_11840	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B4U62_11845	COG1272	protein, Hemolysin III
B4U62_11850	COG0204	Acyl-transferase
B4U62_11855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B4U62_11860	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B4U62_11865	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B4U62_11875	COG2521	methyltransferase
B4U62_11875	COG2136	Putative SAM-dependent methyltransferase
B4U62_11885	COG0129	dihydroxy-acid dehydratase activity
B4U62_11890	COG1413	lyase activity
B4U62_11895	COG1418	mRNA catabolic process
B4U62_11900	COG0386	Belongs to the glutathione peroxidase family
B4U62_11905	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B4U62_11910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B4U62_11915	COG1278	Cold shock
B4U62_11935	COG0328	RNA-DNA hybrid ribonuclease activity
B4U62_11940	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B4U62_11945	COG0328	RNA-DNA hybrid ribonuclease activity
B4U62_11955	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4U62_11970	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B4U62_11980	COG1755	Isoprenylcysteine carboxyl methyltransferase
B4U62_11985	COG3424	synthase
B4U62_11990	COG2233	PERMEase
B4U62_11995	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B4U62_12000	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B4U62_12010	COG0800	Aldolase
B4U62_12015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4U62_12020	COG1609	Transcriptional regulator
B4U62_12025	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
B4U62_12030	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_12035	COG1199	ATP-dependent helicase activity
B4U62_12050	COG0116	Belongs to the methyltransferase superfamily
B4U62_12065	COG4474	Belongs to the UPF0398 family
B4U62_12075	COG3359	exonuclease
B4U62_12080	COG1205	dead DEAH box helicase
B4U62_12080	COG1111	helicase
B4U62_12085	COG2190	(PTS) system
B4U62_12090	COG0071	Belongs to the small heat shock protein (HSP20) family
B4U62_12125	COG3331	DNA recombination
B4U62_12130	COG4499	WXG100 protein secretion system (Wss), protein YukC
B4U62_12130	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4U62_12140	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B4U62_12145	COG3935	DnaD domain protein
B4U62_12150	COG0017	Asparaginyl-tRNA synthetase
B4U62_12155	COG0436	Aminotransferase
B4U62_12160	COG5353	protein conserved in bacteria
B4U62_12170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B4U62_12170	COG1199	ATP-dependent helicase activity
B4U62_12175	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B4U62_12180	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B4U62_12185	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B4U62_12190	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
B4U62_12190	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
B4U62_12195	COG0617	tRNA 3'-terminal CCA addition
B4U62_12200	COG0438	transferase activity, transferring glycosyl groups
B4U62_12205	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B4U62_12210	COG1803	Methylglyoxal synthase
B4U62_12215	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B4U62_12220	COG1694	Mazg nucleotide pyrophosphohydrolase
B4U62_12225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4U62_12235	COG4347	Protein of unknown function (DUF1405)
B4U62_12240	COG2010	Cytochrome c
B4U62_12240	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B4U62_12245	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B4U62_12250	COG0723	plastoquinol--plastocyanin reductase activity
B4U62_12260	COG5582	Belongs to the UPF0302 family
B4U62_12265	COG0457	Tetratricopeptide repeat
B4U62_12270	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B4U62_12275	COG0287	Prephenate dehydrogenase
B4U62_12280	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B4U62_12285	COG0159	tryptophan synthase activity
B4U62_12290	COG0133	tryptophan synthase activity
B4U62_12295	COG0135	phosphoribosylanthranilate isomerase activity
B4U62_12310	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B4U62_12315	COG4401	Chorismate mutase type I
B4U62_12320	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B4U62_12325	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B4U62_12330	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B4U62_12335	COG0105	UTP biosynthetic process
B4U62_12340	COG0142	geranyltranstransferase activity
B4U62_12345	COG2226	methyltransferase
B4U62_12350	COG0142	geranyltranstransferase activity
B4U62_12360	COG0302	gtp cyclohydrolase
B4U62_12365	COG0776	regulation of translation
B4U62_12370	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B4U62_12385	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B4U62_12390	COG1160	GTP binding
B4U62_12415	COG1304	FMN binding
B4U62_12420	COG0539	negative regulation of cytoplasmic translation
B4U62_12425	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B4U62_12435	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
B4U62_12440	COG2959	enzyme of heme biosynthesis
B4U62_12445	COG3409	Peptidoglycan-binding domain 1 protein
B4U62_12445	COG3773	Cell wall hydrolase
B4U62_12450	COG2339	peptidase activity
B4U62_12455	COG0492	ferredoxin-NADP+ reductase activity
B4U62_12460	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B4U62_12465	COG4862	establishment of competence for transformation
B4U62_12470	COG1408	metallophosphoesterase
B4U62_12480	COG1388	LysM domain
B4U62_12485	COG1266	CAAX protease self-immunity
B4U62_12490	COG0514	ATP-dependent DNA helicase (RecQ)
B4U62_12495	COG4955	Helix-turn-helix domain
B4U62_12500	COG1141	Ferredoxin
B4U62_12505	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
B4U62_12510	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B4U62_12515	COG0710	3-dehydroquinate dehydratase activity
B4U62_12525	COG1595	DNA-templated transcription, initiation
B4U62_12530	COG5002	protein histidine kinase activity
B4U62_12535	COG0745	RESPONSE REGULATOR receiver
B4U62_12540	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B4U62_12545	COG1333	cytochrome c biogenesis protein
B4U62_12550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U62_12555	COG1187	pseudouridine synthase activity
B4U62_12560	COG0700	Nucleoside recognition
B4U62_12565	COG2715	membrane protein required for spore maturation
B4U62_12570	COG1686	Belongs to the peptidase S11 family
B4U62_12580	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B4U62_12585	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B4U62_12590	COG1547	Domain of unknown function (DUF309)
B4U62_12595	COG0456	acetyltransferase
B4U62_12600	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B4U62_12605	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B4U62_12605	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B4U62_12610	COG0307	riboflavin synthase, alpha
B4U62_12615	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B4U62_12615	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B4U62_12625	COG0681	Belongs to the peptidase S26 family
B4U62_12635	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
B4U62_12660	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B4U62_12670	COG4086	secreted protein
B4U62_12675	COG0019	diaminopimelate decarboxylase activity
B4U62_12680	COG0697	spore germination
B4U62_12695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B4U62_12715	COG1191	sigma factor activity
B4U62_12720	COG2172	sigma factor antagonist activity
B4U62_12725	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U62_12730	COG1686	Belongs to the peptidase S11 family
B4U62_12735	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B4U62_12740	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B4U62_12745	COG4974	Belongs to the 'phage' integrase family
B4U62_12755	COG0735	belongs to the Fur family
B4U62_12760	COG1300	Membrane
B4U62_12770	COG0281	malic enzyme
B4U62_12775	COG1757	Na H antiporter
B4U62_12780	COG1027	Aspartate ammonia-lyase
B4U62_12785	COG0252	asparaginase activity
B4U62_12790	COG1396	sequence-specific DNA binding
B4U62_12795	COG1379	DNA repair
B4U62_12800	COG0494	nUDIX hydrolase
B4U62_12810	COG0667	Aldo Keto reductase
B4U62_12820	COG1073	alpha beta
B4U62_12830	COG4918	Iron-sulphur cluster biosynthesis
B4U62_12835	COG0456	acetyltransferase
B4U62_12835	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B4U62_12840	COG2329	Antibiotic biosynthesis monooxygenase
B4U62_12845	COG0456	acetyltransferase
B4U62_12855	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B4U62_12865	COG2211	Major facilitator Superfamily
B4U62_12875	COG0346	lactoylglutathione lyase activity
B4U62_12880	COG1072	(Pantothenic acid kinase))
B4U62_12885	COG3048	D-serine ammonia-lyase activity
B4U62_12890	COG0300	oxidoreductase activity
B4U62_12895	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4U62_12900	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4U62_12905	COG4187	Peptidase family M20/M25/M40
B4U62_12910	COG1902	pentaerythritol trinitrate reductase activity
B4U62_12915	COG0596	Alpha beta hydrolase
B4U62_12925	COG1234	tRNA 3'-trailer cleavage
B4U62_12930	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B4U62_12935	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B4U62_12940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B4U62_12950	COG0706	membrane insertase activity
B4U62_12955	COG3361	conserved protein (COG2071)
B4U62_12960	COG2195	Cleaves the N-terminal amino acid of tripeptides
B4U62_12965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B4U62_12970	COG0346	lactoylglutathione lyase activity
B4U62_12975	COG1376	ErfK ybiS ycfS ynhG family protein
B4U62_12980	COG4129	membrane
B4U62_12985	COG1126	abc transporter atp-binding protein
B4U62_12990	COG0765	amino acid transport
B4U62_12995	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4U62_13005	COG1597	lipid kinase activity
B4U62_13010	COG2814	Major facilitator Superfamily
B4U62_13015	COG4978	Transcriptional regulator
B4U62_13015	COG0789	Transcriptional regulator
B4U62_13020	COG0508	dehydrogenase complex catalyzes the overall conversion of
B4U62_13025	COG0022	dehydrogenase e1 component
B4U62_13035	COG3426	butyrate kinase activity
B4U62_13040	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B4U62_13045	COG0280	phosphate acetyltransferase
B4U62_13050	COG3829	transcription factor binding
B4U62_13050	COG3290	protein histidine kinase activity
B4U62_13060	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B4U62_13065	COG2079	MmgE PrpD family protein
B4U62_13070	COG0372	Belongs to the citrate synthase family
B4U62_13075	COG1960	acyl-CoA dehydrogenase activity
B4U62_13080	COG1250	3-hydroxyacyl-CoA dehydrogenase
B4U62_13090	COG0584	glycerophosphoryl diester phosphodiesterase
B4U62_13095	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U62_13105	COG1902	pentaerythritol trinitrate reductase activity
B4U62_13110	COG0745	RESPONSE REGULATOR receiver
B4U62_13115	COG0750	zinc metalloprotease
B4U62_13120	COG0497	DNA recombination
B4U62_13125	COG1438	arginine binding
B4U62_13130	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B4U62_13135	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B4U62_13140	COG0142	geranyltranstransferase activity
B4U62_13145	COG1722	exodeoxyribonuclease VII activity
B4U62_13150	COG1570	exodeoxyribonuclease VII activity
B4U62_13155	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B4U62_13160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B4U62_13165	COG1302	Protein conserved in bacteria
B4U62_13170	COG0439	Biotin carboxylase
B4U62_13175	COG0511	ligase activity, forming carbon-carbon bonds
B4U62_13215	COG3854	ATPases associated with a variety of cellular activities
B4U62_13225	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B4U62_13230	COG0006	proline dipeptidase activity
B4U62_13235	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B4U62_13245	COG3872	metal-dependent enzyme
B4U62_13255	COG1752	Esterase of the alpha-beta hydrolase superfamily
B4U62_13260	COG1321	iron dependent repressor
B4U62_13265	COG0095	Lipoate-protein ligase
B4U62_13270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4U62_13275	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B4U62_13280	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B4U62_13285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B4U62_13290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B4U62_13305	COG1396	sequence-specific DNA binding
B4U62_13315	COG0681	Belongs to the peptidase S26 family
B4U62_13340	COG4940	Competence protein ComGF
B4U62_13350	COG4970	Tfp pilus assembly protein FimT
B4U62_13355	COG4537	Required for transformation and DNA binding
B4U62_13360	COG1459	type II secretion system
B4U62_13365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B4U62_13375	COG0598	Magnesium transport protein CorA
B4U62_13380	COG1253	flavin adenine dinucleotide binding
B4U62_13385	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U62_13395	COG1393	Belongs to the ArsC family
B4U62_13405	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4U62_13415	COG0011	TIGRFAM Protein of
B4U62_13425	COG2866	Carboxypeptidase
B4U62_13430	COG1368	sulfuric ester hydrolase activity
B4U62_13435	COG1940	carbohydrate kinase activity
B4U62_13440	COG4483	Protein conserved in bacteria
B4U62_13445	COG0457	Tetratricopeptide repeat
B4U62_13445	COG0705	Rhomboid family
B4U62_13455	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B4U62_13460	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B4U62_13465	COG0438	transferase activity, transferring glycosyl groups
B4U62_13480	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B4U62_13485	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B4U62_13490	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B4U62_13495	COG0581	inorganic phosphate transmembrane transporter activity
B4U62_13500	COG0573	inorganic phosphate transmembrane transporter activity
B4U62_13505	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B4U62_13515	COG0477	Major facilitator Superfamily
B4U62_13520	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B4U62_13525	COG2839	Protein conserved in bacteria
B4U62_13530	COG5521	maltodextrose utilization protein MalA
B4U62_13540	COG1388	LysM domain
B4U62_13545	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B4U62_13550	COG4709	membrane
B4U62_13555	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
B4U62_13560	COG0735	belongs to the Fur family
B4U62_13565	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4U62_13575	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B4U62_13580	COG0513	Belongs to the DEAD box helicase family
B4U62_13590	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B4U62_13595	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B4U62_13600	COG2384	SAM-dependent methyltransferase
B4U62_13605	COG2010	Cytochrome c
B4U62_13615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B4U62_13620	COG0358	DNA primase activity
B4U62_13625	COG1671	Belongs to the UPF0178 family
B4U62_13630	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B4U62_13635	COG0517	IMP dehydrogenase activity
B4U62_13640	COG0751	glycine-tRNA ligase activity
B4U62_13645	COG0752	glycyl-tRNA synthetase alpha subunit
B4U62_13650	COG1381	Involved in DNA repair and RecF pathway recombination
B4U62_13660	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B4U62_13665	COG0295	cytidine deaminase activity
B4U62_13670	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
B4U62_13675	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
B4U62_13680	COG1480	7TM receptor with intracellular HD hydrolase
B4U62_13685	COG1702	phosphate starvation-inducible protein PhoH
B4U62_13690	COG0561	phosphatase activity
B4U62_13710	COG1030	water channel activity
B4U62_13715	COG1610	YqeY-like protein
B4U62_13720	COG0828	Belongs to the bacterial ribosomal protein bS21 family
B4U62_13725	COG1283	sodium-dependent phosphate transmembrane transporter activity
B4U62_13730	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B4U62_13735	COG1385	rRNA (uridine-N3-)-methyltransferase activity
B4U62_13740	COG2264	protein methyltransferase activity
B4U62_13745	COG0484	heat shock protein binding
B4U62_13750	COG0443	Heat shock 70 kDa protein
B4U62_13755	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
B4U62_13760	COG1420	regulation of RNA biosynthetic process
B4U62_13765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B4U62_13770	COG0481	GTPase activity
B4U62_13780	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U62_13785	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
B4U62_13790	COG0268	Binds directly to 16S ribosomal RNA
B4U62_13795	COG1466	dna polymerase III delta subunit
B4U62_13805	COG0658	competence protein
B4U62_13805	COG2333	competence protein COMEC
B4U62_13810	COG2131	deaminase
B4U62_13815	COG1596	polysaccharide export
B4U62_13815	COG1555	photosystem II stabilization
B4U62_13820	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B4U62_13825	COG2226	methyltransferase
B4U62_13830	COG0799	negative regulation of ribosome biogenesis
B4U62_13835	COG1713	HD superfamily hydrolase involved in NAD metabolism
B4U62_13840	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
B4U62_13845	COG1534	Rna-binding protein
B4U62_13850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
B4U62_13855	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B4U62_13860	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
B4U62_13870	COG2755	lipolytic protein G-D-S-L family
B4U62_13875	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4U62_13875	COG3409	Peptidoglycan-binding domain 1 protein
B4U62_13880	COG0398	Pfam SNARE associated Golgi protein
B4U62_13885	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
B4U62_13895	COG3209	COG3209 Rhs family protein
B4U62_13905	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B4U62_13915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B4U62_13920	COG0798	PFAM Bile acid sodium symporter
B4U62_13925	COG0346	lactoylglutathione lyase activity
B4U62_13930	COG0640	Transcriptional regulator
B4U62_13935	COG3403	YqcI/YcgG family
B4U62_13940	COG0457	Tetratricopeptide repeat
B4U62_13955	COG5444	nuclease activity
B4U62_13975	COG5632	N-Acetylmuramoyl-L-alanine amidase
B4U62_13975	COG3409	Peptidoglycan-binding domain 1 protein
B4U62_13980	COG4824	toxin secretion phage lysis holin
B4U62_14010	COG3778	Protein conserved in bacteria
B4U62_14015	COG3299	homolog of phage Mu protein gp47
B4U62_14020	COG3628	GPW Gp25 family protein
B4U62_14030	COG4193	domain, Protein
B4U62_14035	COG1652	LysM domain
B4U62_14040	COG5280	Phage tail tape measure protein TP901
B4U62_14040	COG3953	SLT domain
B4U62_14105	COG4653	Phage capsid family
B4U62_14110	COG0338	D12 class N6 adenine-specific DNA methyltransferase
B4U62_14120	COG2369	cell adhesion
B4U62_14125	COG5518	Phage portal protein
B4U62_14130	COG1783	phage Terminase large subunit
B4U62_14135	COG5484	DNA packaging
B4U62_14145	COG3677	Transposase
B4U62_14160	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
B4U62_14170	COG1484	DNA-dependent DNA replication
B4U62_14175	COG3935	DnaD domain protein
B4U62_14180	COG3723	Recombinational DNA repair protein, rece pathway
B4U62_14185	COG5377	YqaJ viral recombinase family
B4U62_14210	COG1476	TRANSCRIPTIONal
B4U62_14215	COG3620	sequence-specific DNA binding
B4U62_14225	COG0563	adenylate kinase activity
B4U62_14230	COG2856	Zn peptidase
B4U62_14240	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B4U62_14250	COG3223	Belongs to the PsiE family
B4U62_14255	COG5002	protein histidine kinase activity
B4U62_14255	COG0642	Histidine kinase
B4U62_14260	COG0745	RESPONSE REGULATOR receiver
B4U62_14265	COG2311	Membrane
B4U62_14270	COG0454	-acetyltransferase
B4U62_14275	COG2249	NAD(P)H dehydrogenase (quinone) activity
B4U62_14285	COG0730	response to heat
B4U62_14290	COG0425	Belongs to the sulfur carrier protein TusA family
B4U62_14305	COG0425	Belongs to the sulfur carrier protein TusA family
B4U62_14305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4U62_14315	COG2210	Belongs to the sulfur carrier protein TusA family
B4U62_14320	COG1937	Protein conserved in bacteria
B4U62_14335	COG0662	Cupin 2, conserved barrel domain protein
B4U62_14350	COG4978	Transcriptional regulator
B4U62_14350	COG0789	Transcriptional regulator
B4U62_14355	COG2814	Major facilitator Superfamily
B4U62_14360	COG0456	acetyltransferase
B4U62_14365	COG1253	flavin adenine dinucleotide binding
B4U62_14375	COG0697	spore germination
B4U62_14380	COG0583	DNA-binding transcription factor activity
B4U62_14385	COG2072	flavoprotein involved in K transport
B4U62_14390	COG1230	cation diffusion facilitator family transporter
B4U62_14395	COG1942	4-Oxalocrotonate Tautomerase
B4U62_14400	COG0583	DNA-binding transcription factor activity
B4U62_14410	COG1114	Component of the transport system for branched-chain amino acids
B4U62_14420	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
B4U62_14425	COG1522	sequence-specific DNA binding
B4U62_14430	COG2732	(Barnase) inhibitor
B4U62_14435	COG2124	cytochrome p450
B4U62_14445	COG1335	isochorismatase
B4U62_14455	COG2318	DinB family
B4U62_14465	COG2070	2-Nitropropane dioxygenase
B4U62_14480	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B4U62_14495	COG3443	Belongs to the bacterial solute-binding protein 9 family
B4U62_14500	COG1595	DNA-templated transcription, initiation
B4U62_14505	COG0667	Aldo Keto reductase
B4U62_14510	COG2851	Citrate transporter
B4U62_14515	COG0583	DNA-binding transcription factor activity
B4U62_14520	COG2828	Protein conserved in bacteria
B4U62_14525	COG3409	Peptidoglycan-binding domain 1 protein
B4U62_14530	COG5566	PFAM Mor transcription activator
B4U62_14535	COG0596	Alpha beta hydrolase
B4U62_14540	COG4991	sh3 domain protein
B4U62_14545	COG4991	sh3 domain protein
B4U62_14550	COG0346	lactoylglutathione lyase activity
B4U62_14560	COG5577	PFAM Coat F domain
B4U62_14565	COG1063	alcohol dehydrogenase
B4U62_14575	COG5577	PFAM Coat F domain
B4U62_14580	COG0789	Transcriptional regulator
B4U62_14590	COG1064	alcohol dehydrogenase
B4U62_14595	COG0693	protein deglycase activity
B4U62_14600	COG1621	beta-fructofuranosidase activity
B4U62_14605	COG3716	PTS system mannose fructose sorbose family IID component
B4U62_14610	COG3715	PTS system
B4U62_14615	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U62_14620	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4U62_14625	COG3933	PFAM sigma-54 factor interaction domain-containing protein
B4U62_14625	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B4U62_14630	COG1113	amino acid transport
B4U62_14635	COG1280	lysine exporter protein (LysE YggA)
B4U62_14640	COG1378	Sugar-specific transcriptional regulator TrmB
B4U62_14645	COG1595	DNA-templated transcription, initiation
B4U62_14655	COG2755	lipolytic protein G-D-S-L family
B4U62_14655	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B4U62_14665	COG2124	cytochrome p450
B4U62_14665	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B4U62_14670	COG1309	transcriptional regulator
B4U62_14675	COG2226	methyltransferase
B4U62_14685	COG2116	formate transmembrane transporter activity
B4U62_14690	COG5609	conserved protein (DUF2294)
B4U62_14695	COG3383	formate dehydrogenase (NAD+) activity
B4U62_14700	COG2427	Protein of unknown function (DUF1641)
B4U62_14710	COG0626	cystathionine gamma-synthase activity
B4U62_14715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4U62_14720	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B4U62_14725	COG2226	methyltransferase
B4U62_14740	COG0768	penicillin binding
B4U62_14745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B4U62_14750	COG0572	uridine kinase
B4U62_14770	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B4U62_14775	COG3906	Belongs to the UPF0473 family
B4U62_14780	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B4U62_14785	COG4472	Bacterial protein of unknown function (DUF965)
B4U62_14790	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B4U62_14795	COG0628	permease
B4U62_14800	COG1126	abc transporter atp-binding protein
B4U62_14805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4U62_14810	COG0765	amino acid transport
B4U62_14815	COG0765	amino acid transport
B4U62_14830	COG3881	PFAM PRC-barrel domain
B4U62_14835	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B4U62_14840	COG0457	Tetratricopeptide repeat
B4U62_14845	COG0482	sulfurtransferase activity
B4U62_14850	COG1104	cysteine desulfurase activity
B4U62_14855	COG1959	2 iron, 2 sulfur cluster binding
B4U62_14860	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B4U62_14865	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B4U62_14875	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B4U62_14880	COG0124	histidyl-tRNA synthetase
B4U62_14890	COG4991	sh3 domain protein
B4U62_14890	COG3103	Sh3 type 3 domain protein
B4U62_14890	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U62_14895	COG1490	D-aminoacyl-tRNA deacylase activity
B4U62_14900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B4U62_14905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B4U62_14910	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B4U62_14910	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B4U62_14915	COG5416	Lipopolysaccharide assembly protein A domain
B4U62_14920	COG0490	domain, Protein
B4U62_14925	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4U62_14925	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B4U62_14935	COG2244	polysaccharide biosynthetic process
B4U62_14940	COG2323	membrane
B4U62_14950	COG1862	Preprotein translocase
B4U62_14955	COG0343	queuine tRNA-ribosyltransferase activity
B4U62_14960	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B4U62_14970	COG2255	four-way junction helicase activity
B4U62_14975	COG0632	four-way junction helicase activity
B4U62_14985	COG2814	Major facilitator Superfamily
B4U62_14990	COG0673	inositol 2-dehydrogenase activity
B4U62_14995	COG2112	serine threonine protein kinase
B4U62_15010	COG1115	amino acid carrier protein
B4U62_15015	COG0217	transcriptional regulatory protein
B4U62_15025	COG1388	LysM domain
B4U62_15030	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B4U62_15035	COG0157	Belongs to the NadC ModD family
B4U62_15040	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B4U62_15045	COG1104	cysteine desulfurase activity
B4U62_15050	COG1827	regulation of RNA biosynthetic process
B4U62_15055	COG0077	Prephenate dehydratase
B4U62_15060	COG4492	Belongs to the UPF0735 family
B4U62_15065	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B4U62_15070	COG3290	protein histidine kinase activity
B4U62_15075	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B4U62_15080	COG2868	ribosomal protein
B4U62_15085	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B4U62_15090	COG1994	Peptidase M50
B4U62_15095	COG0739	heme binding
B4U62_15100	COG2894	cell division
B4U62_15105	COG0850	regulation of cytokinetic process
B4U62_15110	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
B4U62_15115	COG1792	Involved in formation and maintenance of cell shape
B4U62_15120	COG1077	Cell shape determining protein MreB Mrl
B4U62_15125	COG2003	Belongs to the UPF0758 family
B4U62_15130	COG0424	maF-like protein
B4U62_15140	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B4U62_15145	COG0285	dihydrofolate synthase activity
B4U62_15150	COG0525	valine-tRNA ligase activity
B4U62_15160	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B4U62_15165	COG1388	LysM domain
B4U62_15170	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B4U62_15175	COG0113	porphobilinogen synthase activity
B4U62_15180	COG1587	Uroporphyrinogen-III synthase
B4U62_15185	COG0181	hydroxymethylbilane synthase activity
B4U62_15190	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B4U62_15195	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B4U62_15205	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B4U62_15210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B4U62_15215	COG0470	DNA polymerase III
B4U62_15215	COG1067	ATP-dependent peptidase activity
B4U62_15220	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B4U62_15225	COG0544	peptidyl-prolyl cis-trans isomerase activity
B4U62_15230	COG0457	Tetratricopeptide repeat
B4U62_15230	COG1477	protein flavinylation
B4U62_15235	COG0066	3-isopropylmalate dehydratase activity
B4U62_15240	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B4U62_15245	COG0473	3-isopropylmalate dehydrogenase activity
B4U62_15250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B4U62_15255	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B4U62_15260	COG0440	acetolactate synthase activity
B4U62_15265	COG0028	Belongs to the TPP enzyme family
B4U62_15280	COG0454	-acetyltransferase
B4U62_15285	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
B4U62_15295	COG0622	Phosphoesterase
B4U62_15300	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B4U62_15305	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B4U62_15310	COG5401	PFAM Sporulation and spore germination
B4U62_15315	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B4U62_15320	COG1846	Transcriptional regulator
B4U62_15325	COG2197	response regulator
B4U62_15330	COG0824	Thioesterase
B4U62_15335	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B4U62_15340	COG1053	succinate dehydrogenase
B4U62_15345	COG2009	succinate dehydrogenase
B4U62_15350	COG1719	4-vinyl reductase, 4VR
B4U62_15355	COG0527	aspartate kinase activity
B4U62_15365	COG0322	excinuclease ABC activity
B4U62_15370	COG3118	belongs to the thioredoxin family
B4U62_15380	COG3534	alpha-L-arabinofuranosidase
B4U62_15385	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B4U62_15390	COG2086	electron transfer activity
B4U62_15395	COG1024	Enoyl-CoA hydratase
B4U62_15400	COG1309	transcriptional regulator
B4U62_15405	COG0318	PFAM AMP-dependent synthetase and ligase
B4U62_15410	COG3766	membrane
B4U62_15415	COG1193	negative regulation of DNA recombination
B4U62_15420	COG1796	DNA polymerase
B4U62_15420	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B4U62_15425	COG1286	toxin biosynthetic process
B4U62_15430	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
B4U62_15435	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B4U62_15440	COG0072	phenylalanine-tRNA ligase activity
B4U62_15440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4U62_15445	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B4U62_15455	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B4U62_15465	COG3835	regulator
B4U62_15470	COG0277	FAD linked oxidase domain protein
B4U62_15475	COG0247	lactate metabolic process
B4U62_15480	COG0346	lactoylglutathione lyase activity
B4U62_15485	COG1966	Carbon starvation protein
B4U62_15490	COG3534	alpha-L-arabinofuranosidase
B4U62_15495	COG0395	ABC-type sugar transport system, permease component
B4U62_15500	COG1175	transmembrane transport
B4U62_15505	COG1653	transport
B4U62_15510	COG0371	Dehydrogenase
B4U62_15515	COG0647	UMP catabolic process
B4U62_15520	COG0235	Class ii aldolase
B4U62_15525	COG1069	ribulokinase activity
B4U62_15530	COG2160	L-arabinose isomerase activity
B4U62_15535	COG3507	Belongs to the glycosyl hydrolase 43 family
B4U62_15540	COG1363	Peptidase, m42
B4U62_15550	COG3326	Membrane
B4U62_15555	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B4U62_15560	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B4U62_15565	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B4U62_15575	COG1346	cytolysis
B4U62_15580	COG1380	Effector of murein hydrolase LrgA
B4U62_15585	COG3279	Response regulator of the LytR AlgR family
B4U62_15590	COG3275	phosphorelay sensor kinase activity
B4U62_15600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B4U62_15610	COG0398	Pfam SNARE associated Golgi protein
B4U62_15615	COG1484	DNA-dependent DNA replication
B4U62_15620	COG3611	Membrane attachment protein
B4U62_15625	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B4U62_15630	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B4U62_15635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B4U62_15640	COG1733	regulation of RNA biosynthetic process
B4U62_15645	COG2814	Major facilitator Superfamily
B4U62_15650	COG0656	L-ascorbic acid biosynthetic process
B4U62_15655	COG0237	dephospho-CoA kinase activity
B4U62_15660	COG1971	Probably functions as a manganese efflux pump
B4U62_15665	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B4U62_15670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4U62_15670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B4U62_15675	COG5002	protein histidine kinase activity
B4U62_15680	COG0745	RESPONSE REGULATOR receiver
B4U62_15685	COG0039	L-malate dehydrogenase activity
B4U62_15690	COG0538	isocitrate dehydrogenase activity
B4U62_15695	COG0372	Belongs to the citrate synthase family
B4U62_15700	COG2707	UPF0756 membrane protein
B4U62_15705	COG0628	permease
B4U62_15710	COG3030	protein affecting phage T7 exclusion by the F plasmid
B4U62_15715	COG0469	pyruvate kinase activity
B4U62_15720	COG0205	6-phosphofructokinase activity
B4U62_15725	COG0825	malonyl-CoA metabolic process
B4U62_15730	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B4U62_15735	COG0281	malic enzyme
B4U62_15740	COG0587	DNA-directed DNA polymerase activity
B4U62_15760	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B4U62_15770	COG4109	DRTGG domain
B4U62_15775	COG0730	response to heat
B4U62_15780	COG1473	amidohydrolase
B4U62_15785	COG0196	riboflavin kinase activity
B4U62_15790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U62_15795	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B4U62_15800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U62_15805	COG1126	abc transporter atp-binding protein
B4U62_15810	COG0765	amino acid transport
B4U62_15815	COG0765	amino acid transport
B4U62_15820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4U62_15825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4U62_15830	COG0454	-acetyltransferase
B4U62_15835	COG0583	DNA-binding transcription factor activity
B4U62_15840	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B4U62_15845	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_15855	COG0165	Argininosuccinate lyase
B4U62_15860	COG0137	argininosuccinate synthase activity
B4U62_15865	COG0521	Mo-molybdopterin cofactor biosynthetic process
B4U62_15870	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B4U62_15880	COG0827	DNA restriction-modification system
B4U62_15885	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
B4U62_15890	COG3874	Sporulation protein YtfJ
B4U62_15900	COG1714	RDD family
B4U62_15905	COG0616	signal peptide processing
B4U62_15910	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B4U62_15915	COG1574	metal-dependent hydrolase with the TIM-barrel fold
B4U62_15920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B4U62_15930	COG0301	tRNA thio-modification
B4U62_15935	COG1104	cysteine desulfurase activity
B4U62_15940	COG1114	Component of the transport system for branched-chain amino acids
B4U62_15945	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
B4U62_15950	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B4U62_15955	COG1309	transcriptional regulator
B4U62_15960	COG1956	GAF domain-containing protein
B4U62_15965	COG2203	Gaf domain
B4U62_15965	COG2199	diguanylate cyclase activity
B4U62_15975	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B4U62_15980	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B4U62_15990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B4U62_15995	COG0454	-acetyltransferase
B4U62_16000	COG0517	IMP dehydrogenase activity
B4U62_16005	COG0123	including yeast histone deacetylase and acetoin utilization protein
B4U62_16010	COG1360	Flagellar Motor Protein
B4U62_16015	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B4U62_16020	COG1609	Transcriptional regulator
B4U62_16025	COG1605	Chorismate mutase
B4U62_16025	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B4U62_16030	COG3118	belongs to the thioredoxin family
B4U62_16035	COG4980	gas vesicle protein
B4U62_16040	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
B4U62_16045	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B4U62_16050	COG1674	ftsk spoiiie
B4U62_16055	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B4U62_16060	COG4848	Belongs to the UPF0354 family
B4U62_16065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U62_16075	COG1363	Peptidase, m42
B4U62_16080	COG5584	Small secreted protein
B4U62_16085	COG0281	malic enzyme
B4U62_16090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4U62_16095	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B4U62_16105	COG0510	thiamine kinase activity
B4U62_16110	COG1523	belongs to the glycosyl hydrolase 13 family
B4U62_16115	COG1597	lipid kinase activity
B4U62_16125	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B4U62_16130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B4U62_16135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4U62_16140	COG2252	PERMEase
B4U62_16145	COG4473	ABC transporter
B4U62_16150	COG1131	(ABC) transporter
B4U62_16155	COG1349	DNA-binding transcription factor activity
B4U62_16160	COG1187	pseudouridine synthase activity
B4U62_16165	COG2244	polysaccharide biosynthetic process
B4U62_16170	COG2081	HI0933 family
B4U62_16175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B4U62_16185	COG5578	integral membrane protein
B4U62_16190	COG0673	inositol 2-dehydrogenase activity
B4U62_16195	COG1653	transport
B4U62_16200	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
B4U62_16205	COG4209	transmembrane transport
B4U62_16210	COG2207	Transcriptional regulator
B4U62_16215	COG1653	transport
B4U62_16220	COG0395	ABC-type sugar transport system, permease component
B4U62_16225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B4U62_16230	COG2124	cytochrome p450
B4U62_16235	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B4U62_16240	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B4U62_16245	COG0156	8-amino-7-oxononanoate synthase activity
B4U62_16250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B4U62_16255	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
B4U62_16260	COG1073	alpha beta
B4U62_16285	COG1486	melibiose metabolic process
B4U62_16290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B4U62_16295	COG0495	leucyl-tRNA aminoacylation
B4U62_16305	COG2202	Pas domain
B4U62_16305	COG1366	Belongs to the anti-sigma-factor antagonist family
B4U62_16310	COG2814	Major facilitator Superfamily
B4U62_16315	COG2433	Pfam Transposase IS66
B4U62_16320	COG0577	efflux transmembrane transporter activity
B4U62_16325	COG1136	(ABC) transporter
B4U62_16330	COG2205	protein histidine kinase activity
B4U62_16335	COG0745	RESPONSE REGULATOR receiver
B4U62_16340	COG0577	efflux transmembrane transporter activity
B4U62_16345	COG1136	(ABC) transporter
B4U62_16360	COG1131	(ABC) transporter
B4U62_16365	COG1725	Transcriptional regulator
B4U62_16375	COG1242	4 iron, 4 sulfur cluster binding
B4U62_16380	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B4U62_16390	COG2267	carboxylic ester hydrolase activity
B4U62_16395	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B4U62_16400	COG1113	amino acid transport
B4U62_16405	COG0367	asparagine synthase
B4U62_16410	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B4U62_16415	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B4U62_16425	COG1506	peptidase
B4U62_16430	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B4U62_16435	COG1116	anion transmembrane transporter activity
B4U62_16440	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B4U62_16445	COG0494	nUDIX hydrolase
B4U62_16450	COG4824	toxin secretion phage lysis holin
B4U62_16455	COG0783	Belongs to the Dps family
B4U62_16470	COG1854	S-ribosylhomocysteine lyase activity
B4U62_16475	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B4U62_16480	COG0288	reversible hydration of carbon dioxide
B4U62_16485	COG0254	rRNA binding
B4U62_16490	COG1271	oxidase subunit
B4U62_16495	COG1294	oxidase, subunit
B4U62_16505	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4U62_16510	COG1321	iron dependent repressor
B4U62_16510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B4U62_16515	COG1121	(ABC) transporter
B4U62_16520	COG0803	Belongs to the bacterial solute-binding protein 9 family
B4U62_16530	COG4948	Mandelate Racemase Muconate Lactonizing
B4U62_16535	COG0318	PFAM AMP-dependent synthetase and ligase
B4U62_16540	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B4U62_16545	COG0596	Alpha beta hydrolase
B4U62_16550	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B4U62_16555	COG1169	isochorismate synthase
B4U62_16565	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B4U62_16570	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B4U62_16575	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B4U62_16580	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B4U62_16585	COG0438	transferase activity, transferring glycosyl groups
B4U62_16595	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B4U62_16600	COG0438	transferase activity, transferring glycosyl groups
B4U62_16605	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B4U62_16610	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
B4U62_16615	COG0058	SHG alpha-glucan phosphorylase activity
B4U62_16620	COG0297	glycogen (starch) synthase activity
B4U62_16625	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B4U62_16630	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B4U62_16635	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B4U62_16760	COG3859	Proton-coupled thiamine transporter YuaJ
B4U62_16765	COG1247	-acetyltransferase
B4U62_16770	COG2268	Band 7 protein
B4U62_16775	COG1585	Membrane protein implicated in regulation of membrane protease activity
B4U62_16780	COG2318	DinB family
B4U62_16790	COG1454	alcohol dehydrogenase
B4U62_16800	COG1510	regulation of RNA biosynthetic process
B4U62_16810	COG0569	domain protein
B4U62_16815	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B4U62_16820	COG4682	membrane
B4U62_16825	COG1705	Flagellar rod assembly protein muramidase FlgJ
B4U62_16830	COG0477	Major facilitator Superfamily
B4U62_16835	COG5553	Cysteine dioxygenase type I
B4U62_16845	COG1968	undecaprenyl-diphosphatase activity
B4U62_16850	COG0628	permease
B4U62_16855	COG0673	inositol 2-dehydrogenase activity
B4U62_16860	COG4806	L-rhamnose isomerase
B4U62_16865	COG3254	rhamnose metabolic process
B4U62_16870	COG1070	Carbohydrate kinase
B4U62_16875	COG1349	DNA-binding transcription factor activity
B4U62_16880	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_16880	COG3347	Dehydrogenase
B4U62_16890	COG0840	transmembrane signaling receptor activity
B4U62_16895	COG0840	transmembrane signaling receptor activity
B4U62_16900	COG0840	transmembrane signaling receptor activity
B4U62_16905	COG0840	transmembrane signaling receptor activity
B4U62_16920	COG0432	Pfam Uncharacterised protein family UPF0047
B4U62_16925	COG0366	Alpha amylase catalytic
B4U62_16930	COG1253	flavin adenine dinucleotide binding
B4U62_16935	COG2738	Putative neutral zinc metallopeptidase
B4U62_16950	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B4U62_16965	COG0166	Belongs to the GPI family
B4U62_16970	COG1979	alcohol dehydrogenase
B4U62_16975	COG1979	alcohol dehydrogenase
B4U62_16980	COG2155	Conserved Protein
B4U62_16985	COG1098	S1 RNA binding domain
B4U62_16990	COG0436	Aminotransferase
B4U62_16995	COG1522	sequence-specific DNA binding
B4U62_17000	COG2267	carboxylic ester hydrolase activity
B4U62_17010	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B4U62_17015	COG2205	protein histidine kinase activity
B4U62_17025	COG5018	Exonuclease
B4U62_17035	COG2814	Major facilitator Superfamily
B4U62_17040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4U62_17045	COG3011	Protein conserved in bacteria
B4U62_17055	COG3290	protein histidine kinase activity
B4U62_17060	COG4565	transcriptional regulatory protein
B4U62_17085	COG3493	citrate carrier protein
B4U62_17095	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B4U62_17095	COG2111	Na H antiporter
B4U62_17100	COG2111	Na H antiporter
B4U62_17105	COG1006	Multisubunit Na H antiporter MnhC subunit
B4U62_17110	COG0651	ATP synthesis coupled electron transport
B4U62_17115	COG1863	multisubunit Na H antiporter MnhE subunit
B4U62_17120	COG2212	antiporter activity
B4U62_17125	COG1320	monovalent cation:proton antiporter activity
B4U62_17130	COG2050	protein possibly involved in aromatic compounds catabolism
B4U62_17135	COG2197	response regulator
B4U62_17140	COG4585	Histidine kinase
B4U62_17150	COG0142	geranyltranstransferase activity
B4U62_17165	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
B4U62_17170	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B4U62_17175	COG1335	isochorismatase
B4U62_17180	COG5506	Protein of unknown function (DUF1694)
B4U62_17195	COG0628	permease
B4U62_17210	COG1418	mRNA catabolic process
B4U62_17215	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_17225	COG1511	domain protein
B4U62_17230	COG0433	COG0433 Predicted ATPase
B4U62_17230	COG1674	ftsk spoiiie
B4U62_17235	COG4499	WXG100 protein secretion system (Wss), protein YukC
B4U62_17240	COG5417	Belongs to the EsaB family
B4U62_17245	COG4842	Belongs to the WXG100 family
B4U62_17250	COG2508	Transcriptional regulator
B4U62_17250	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
B4U62_17255	COG0686	Belongs to the AlaDH PNT family
B4U62_17260	COG5634	Uncharacterized conserved protein (DUF2278)
B4U62_17265	COG3251	PFAM MbtH domain protein
B4U62_17270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U62_17275	COG1535	isochorismatase
B4U62_17275	COG3433	isochorismatase activity
B4U62_17280	COG1021	2,3-dihydroxybenzoate-AMP ligase
B4U62_17285	COG1169	isochorismate synthase
B4U62_17290	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_17295	COG2819	hydrolase of the alpha beta superfamily
B4U62_17300	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B4U62_17305	COG1268	BioY protein
B4U62_17310	COG2056	Na+-H+ antiporter family
B4U62_17315	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B4U62_17320	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
B4U62_17325	COG3584	3D domain protein
B4U62_17340	COG1252	NADH dehydrogenase
B4U62_17345	COG0492	ferredoxin-NADP+ reductase activity
B4U62_17355	COG0516	GMP reductase activity
B4U62_17360	COG2808	Putative FMN-binding domain
B4U62_17365	COG0456	acetyltransferase
B4U62_17370	COG0316	Belongs to the HesB IscA family
B4U62_17375	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B4U62_17380	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4U62_17385	COG4844	belongs to the
B4U62_17390	COG1252	NADH dehydrogenase
B4U62_17395	COG4837	Protein of unknown function (DUF1462)
B4U62_17400	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B4U62_17405	COG0823	Involved in the tonB-independent uptake of proteins
B4U62_17405	COG1506	peptidase
B4U62_17405	COG4946	Tricorn protease homolog
B4U62_17410	COG0083	homoserine kinase activity
B4U62_17415	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B4U62_17420	COG0460	homoserine dehydrogenase
B4U62_17425	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B4U62_17430	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B4U62_17435	COG0647	UMP catabolic process
B4U62_17440	COG2445	Protein of unknown function DUF86
B4U62_17445	COG4470	Protein conserved in bacteria
B4U62_17455	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B4U62_17460	COG0739	heme binding
B4U62_17470	COG3377	Domain of unknown function (DUF1805)
B4U62_17475	COG0737	Belongs to the 5'-nucleotidase family
B4U62_17480	COG0730	response to heat
B4U62_17485	COG1801	Protein of unknown function DUF72
B4U62_17495	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B4U62_17500	COG2508	Transcriptional regulator
B4U62_17505	COG2233	PERMEase
B4U62_17510	COG2233	PERMEase
B4U62_17515	COG3195	allantoin biosynthetic process
B4U62_17515	COG3648	Uricase
B4U62_17520	COG2351	hydroxyisourate hydrolase activity
B4U62_17530	COG2080	2 iron, 2 sulfur cluster binding
B4U62_17535	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B4U62_17540	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B4U62_17545	COG2068	MobA-Related Protein
B4U62_17550	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B4U62_17555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B4U62_17560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B4U62_17565	COG2356	endonuclease I
B4U62_17570	COG3842	ATPase activity
B4U62_17575	COG2188	Transcriptional regulator
B4U62_17580	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4U62_17585	COG0395	ABC-type sugar transport system, permease component
B4U62_17590	COG1175	transmembrane transport
B4U62_17595	COG1653	transport
B4U62_17600	COG2222	sugar isomerase
B4U62_17605	COG0322	excinuclease ABC activity
B4U62_17610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B4U62_17625	COG0346	lactoylglutathione lyase activity
B4U62_17630	COG0640	Transcriptional regulator
B4U62_17635	COG0719	Fe-S assembly protein
B4U62_17640	COG0822	iron-sulfur transferase activity
B4U62_17645	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B4U62_17650	COG0719	Fe-S assembly protein
B4U62_17655	COG0396	ATPase activity
B4U62_17670	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B4U62_17675	COG1464	Belongs to the NlpA lipoprotein family
B4U62_17680	COG2011	ABC-type metal ion transport system permease component
B4U62_17685	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B4U62_17695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B4U62_17700	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B4U62_17710	COG0509	glycine decarboxylation via glycine cleavage system
B4U62_17715	COG1393	Belongs to the ArsC family
B4U62_17720	COG1960	acyl-CoA dehydrogenase activity
B4U62_17725	COG0183	Belongs to the thiolase family
B4U62_17730	COG1024	Enoyl-CoA hydratase
B4U62_17730	COG1250	3-hydroxyacyl-CoA dehydrogenase
B4U62_17740	COG0506	proline dehydrogenase activity
B4U62_17750	COG5577	PFAM Coat F domain
B4U62_17755	COG1846	Transcriptional regulator
B4U62_17760	COG0477	Major facilitator Superfamily
B4U62_17765	COG1942	4-Oxalocrotonate Tautomerase
B4U62_17775	COG0583	DNA-binding transcription factor activity
B4U62_17785	COG1120	ATPase activity
B4U62_17805	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_17810	COG0783	Belongs to the Dps family
B4U62_17815	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4U62_17820	COG0745	RESPONSE REGULATOR receiver
B4U62_17825	COG2770	Histidine kinase
B4U62_17825	COG2205	protein histidine kinase activity
B4U62_17835	COG1309	transcriptional regulator
B4U62_17840	COG0114	fumarate hydratase activity
B4U62_17850	COG0697	spore germination
B4U62_17855	COG0814	amino acid
B4U62_17865	COG2197	response regulator
B4U62_17870	COG4585	Histidine kinase
B4U62_17875	COG4758	membrane
B4U62_17880	COG3595	metallopeptidase activity
B4U62_17885	COG1842	Phage shock protein A
B4U62_17890	COG4758	membrane
B4U62_17895	COG2814	Major facilitator Superfamily
B4U62_17900	COG2096	Adenosyltransferase
B4U62_17905	COG1120	ATPase activity
B4U62_17910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U62_17915	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4U62_17920	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_17930	COG2205	protein histidine kinase activity
B4U62_17935	COG0745	RESPONSE REGULATOR receiver
B4U62_17945	COG1191	sigma factor activity
B4U62_17955	COG2140	Oxalate decarboxylase
B4U62_17965	COG0577	efflux transmembrane transporter activity
B4U62_17970	COG1136	(ABC) transporter
B4U62_17975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B4U62_17980	COG1120	ATPase activity
B4U62_17985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U62_17990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B4U62_17995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4U62_18005	COG0531	amino acid
B4U62_18020	COG1988	membrane-bound metal-dependent
B4U62_18025	COG1368	sulfuric ester hydrolase activity
B4U62_18030	COG1910	domain protein
B4U62_18035	COG0725	ABC transporter, periplasmic molybdate-binding protein
B4U62_18040	COG4149	molybdate abc transporter
B4U62_18045	COG0656	L-ascorbic acid biosynthetic process
B4U62_18055	COG0025	NhaP-type Na H and K H
B4U62_18060	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B4U62_18065	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B4U62_18070	COG3973	AAA domain
B4U62_18075	COG2860	membrane
B4U62_18080	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B4U62_18085	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B4U62_18090	COG2217	Heavy metal translocating P-type atpase
B4U62_18095	COG2217	Heavy metal translocating P-type atpase
B4U62_18100	COG2608	mercury ion transmembrane transporter activity
B4U62_18105	COG1937	Protein conserved in bacteria
B4U62_18110	COG0673	inositol 2-dehydrogenase activity
B4U62_18115	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B4U62_18120	COG1289	transmembrane transporter activity
B4U62_18130	COG2076	Multidrug Resistance protein
B4U62_18135	COG1309	transcriptional regulator
B4U62_18140	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_18150	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B4U62_18155	COG0557	exoribonuclease II activity
B4U62_18160	COG1647	Serine aminopeptidase, S33
B4U62_18165	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B4U62_18170	COG0596	Alpha beta hydrolase
B4U62_18175	COG1476	TRANSCRIPTIONal
B4U62_18180	COG1396	sequence-specific DNA binding
B4U62_18185	COG1396	sequence-specific DNA binding
B4U62_18190	COG1733	regulation of RNA biosynthetic process
B4U62_18195	COG0840	transmembrane signaling receptor activity
B4U62_18200	COG1174	glycine betaine transport
B4U62_18205	COG1732	Glycine betaine
B4U62_18210	COG1174	glycine betaine transport
B4U62_18215	COG0517	IMP dehydrogenase activity
B4U62_18215	COG1125	glycine betaine transport
B4U62_18220	COG1510	regulation of RNA biosynthetic process
B4U62_18240	COG5658	integral membrane protein
B4U62_18245	COG0640	Transcriptional regulator
B4U62_18250	COG1174	glycine betaine transport
B4U62_18255	COG1732	Glycine betaine
B4U62_18260	COG1174	glycine betaine transport
B4U62_18265	COG0517	IMP dehydrogenase activity
B4U62_18265	COG1125	glycine betaine transport
B4U62_18270	COG1510	regulation of RNA biosynthetic process
B4U62_18275	COG2095	MarC family integral membrane protein
B4U62_18285	COG3064	Membrane
B4U62_18290	COG4640	response to antibiotic
B4U62_18295	COG0456	acetyltransferase
B4U62_18300	COG0148	phosphopyruvate hydratase activity
B4U62_18305	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B4U62_18310	COG0149	triose-phosphate isomerase activity
B4U62_18315	COG0126	phosphoglycerate kinase activity
B4U62_18320	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B4U62_18325	COG2390	Transcriptional regulator
B4U62_18330	COG2814	Major facilitator Superfamily
B4U62_18335	COG1609	Transcriptional regulator
B4U62_18340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U62_18350	COG0583	DNA-binding transcription factor activity
B4U62_18355	COG0697	spore germination
B4U62_18360	COG1113	amino acid transport
B4U62_18365	COG3858	chitin binding
B4U62_18370	COG1556	Lactate utilization protein
B4U62_18375	COG1139	Iron-sulfur cluster binding protein
B4U62_18380	COG0247	lactate metabolic process
B4U62_18385	COG2197	response regulator
B4U62_18395	COG0842	Transport permease protein
B4U62_18400	COG1131	(ABC) transporter
B4U62_18405	COG0596	Alpha beta hydrolase
B4U62_18410	COG2208	phosphoserine phosphatase activity
B4U62_18415	COG3867	Arabinogalactan endo-beta-1,4-galactanase
B4U62_18420	COG1874	Beta-galactosidase
B4U62_18425	COG3833	ABC-type maltose transport systems, permease component
B4U62_18430	COG1175	transmembrane transport
B4U62_18435	COG2182	Extracellular solute-binding protein
B4U62_18440	COG1609	Transcriptional regulator
B4U62_18445	COG2186	Transcriptional regulator
B4U62_18450	COG1620	l-lactate permease
B4U62_18455	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B4U62_18465	COG5039	Polysaccharide pyruvyl transferase
B4U62_18470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B4U62_18475	COG0110	maltose O-acetyltransferase activity
B4U62_18480	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B4U62_18485	COG2244	polysaccharide biosynthetic process
B4U62_18490	COG1216	Glycosyl transferase, family 2
B4U62_18495	COG5039	Polysaccharide pyruvyl transferase
B4U62_18500	COG1216	Glycosyl transferase, family 2
B4U62_18510	COG0438	transferase activity, transferring glycosyl groups
B4U62_18515	COG1215	transferase activity, transferring glycosyl groups
B4U62_18520	COG0438	transferase activity, transferring glycosyl groups
B4U62_18525	COG1086	Polysaccharide biosynthesis protein
B4U62_18530	COG0489	protein tyrosine kinase activity
B4U62_18535	COG3944	biosynthesis protein
B4U62_18540	COG1396	sequence-specific DNA binding
B4U62_18545	COG2272	Belongs to the type-B carboxylesterase lipase family
B4U62_18555	COG3479	Phenolic acid decarboxylase
B4U62_18570	COG1794	racemase activity, acting on amino acids and derivatives
B4U62_18575	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B4U62_18580	COG1621	beta-fructofuranosidase activity
B4U62_18585	COG1621	beta-fructofuranosidase activity
B4U62_18590	COG0531	amino acid
B4U62_18595	COG1309	transcriptional regulator
B4U62_18600	COG2076	Multidrug Resistance protein
B4U62_18605	COG2076	Multidrug Resistance protein
B4U62_18615	COG0277	FAD linked oxidase domain protein
B4U62_18620	COG3621	Patatin-like phospholipase
B4U62_18630	COG0740	serine-type endopeptidase activity
B4U62_18635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B4U62_18640	COG0366	Alpha amylase catalytic
B4U62_18645	COG1554	hydrolase, family 65, central catalytic
B4U62_18650	COG5521	maltodextrose utilization protein MalA
B4U62_18655	COG3833	ABC-type maltose transport systems, permease component
B4U62_18660	COG1175	transmembrane transport
B4U62_18665	COG2182	Extracellular solute-binding protein
B4U62_18670	COG0366	Alpha amylase catalytic
B4U62_18675	COG1609	Transcriptional regulator
B4U62_18680	COG1611	Belongs to the LOG family
B4U62_18685	COG1694	Mazg nucleotide pyrophosphohydrolase
B4U62_18690	COG0659	secondary active sulfate transmembrane transporter activity
B4U62_18695	COG0288	reversible hydration of carbon dioxide
B4U62_18700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B4U62_18705	COG0577	efflux transmembrane transporter activity
B4U62_18710	COG1136	(ABC) transporter
B4U62_18715	COG5002	protein histidine kinase activity
B4U62_18720	COG0745	RESPONSE REGULATOR receiver
B4U62_18730	COG2162	N-hydroxyarylamine O-acetyltransferase activity
B4U62_18735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4U62_18740	COG1481	regulation of sporulation
B4U62_18745	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B4U62_18750	COG1660	Displays ATPase and GTPase activities
B4U62_18755	COG1051	belongs to the nudix hydrolase family
B4U62_18760	COG0492	ferredoxin-NADP+ reductase activity
B4U62_18765	COG0791	NLP P60 protein
B4U62_18765	COG3883	PFAM NLP P60 protein
B4U62_18770	COG0457	Tetratricopeptide repeat
B4U62_18775	COG1132	(ABC) transporter
B4U62_18795	COG0140	phosphoribosyl-ATP diphosphatase activity
B4U62_18795	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B4U62_18800	COG0107	imidazoleglycerol-phosphate synthase activity
B4U62_18805	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B4U62_18810	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B4U62_18815	COG0131	Imidazoleglycerol-phosphate dehydratase
B4U62_18820	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B4U62_18825	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B4U62_18830	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B4U62_18835	COG4990	cell redox homeostasis
B4U62_18840	COG5297	Belongs to the glycosyl hydrolase family 6
B4U62_18845	COG0110	maltose O-acetyltransferase activity
B4U62_18850	COG0546	phosphoglycolate phosphatase activity
B4U62_18855	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B4U62_18860	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B4U62_18865	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B4U62_18870	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B4U62_18875	COG0363	glucosamine-6-phosphate deaminase activity
B4U62_18885	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B4U62_18890	COG1846	Transcriptional regulator
B4U62_18895	COG2124	cytochrome p450
B4U62_18905	COG1846	Transcriptional regulator
B4U62_18910	COG2814	Major facilitator Superfamily
B4U62_18915	COG1950	PFAM Membrane protein of
B4U62_18920	COG1983	PspC domain protein
B4U62_18925	COG3595	metallopeptidase activity
B4U62_18940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B4U62_18945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B4U62_18950	COG0556	nucleotide-excision repair
B4U62_18955	COG4897	Protein conserved in bacteria
B4U62_18960	COG3848	Pyruvate phosphate dikinase
B4U62_18960	COG0574	Belongs to the PEP-utilizing enzyme family
B4U62_18965	COG1309	transcriptional regulator
B4U62_18970	COG2814	Major facilitator Superfamily
B4U62_18975	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4U62_18985	COG0793	Belongs to the peptidase S41A family
B4U62_18985	COG3409	Peptidoglycan-binding domain 1 protein
B4U62_18990	COG2177	Part of the ABC transporter FtsEX involved in
B4U62_18995	COG2884	Cell division ATP-binding protein ftsE
B4U62_19000	COG2010	Cytochrome c
B4U62_19005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4U62_19015	COG0653	protein targeting
B4U62_19020	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B4U62_19035	COG1516	flagellar protein fliS
B4U62_19040	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B4U62_19045	COG1334	flagellar protein FlaG
B4U62_19050	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B4U62_19055	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B4U62_19060	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
B4U62_19070	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B4U62_19075	COG4786	Flagellar basal body rod
B4U62_19075	COG1256	bacterial-type flagellum assembly
B4U62_19080	COG3418	PFAM FlgN family protein
B4U62_19085	COG2747	anti-sigma28 factor FlgM
B4U62_19095	COG1040	competence protein
B4U62_19105	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
B4U62_19110	COG1307	EDD domain protein, DegV family
B4U62_19115	COG2197	response regulator
B4U62_19120	COG4585	Histidine kinase
B4U62_19125	COG1739	Uncharacterized protein family UPF0029
B4U62_19130	COG1316	TRANSCRIPTIONal
B4U62_19135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B4U62_19140	COG0438	transferase activity, transferring glycosyl groups
B4U62_19145	COG1215	transferase activity, transferring glycosyl groups
B4U62_19150	COG3206	protein involved in exopolysaccharide biosynthesis
B4U62_19155	COG3307	-O-antigen
B4U62_19160	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B4U62_19165	COG0438	transferase activity, transferring glycosyl groups
B4U62_19165	COG0297	glycogen (starch) synthase activity
B4U62_19170	COG2244	polysaccharide biosynthetic process
B4U62_19180	COG2247	cell wall binding repeat
B4U62_19180	COG0860	N-Acetylmuramoyl-L-alanine amidase
B4U62_19185	COG2385	sporulation resulting in formation of a cellular spore
B4U62_19185	COG2247	cell wall binding repeat
B4U62_19195	COG1316	TRANSCRIPTIONal
B4U62_19200	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B4U62_19205	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B4U62_19215	COG1215	transferase activity, transferring glycosyl groups
B4U62_19215	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4U62_19220	COG0463	Glycosyl transferase, family 2
B4U62_19230	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4U62_19240	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B4U62_19245	COG1134	teichoic acid transport
B4U62_19250	COG1682	transport, permease protein
B4U62_19255	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4U62_19260	COG0438	transferase activity, transferring glycosyl groups
B4U62_19265	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B4U62_19270	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B4U62_19275	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4U62_19285	COG4193	domain, Protein
B4U62_19290	COG1482	cell wall glycoprotein biosynthetic process
B4U62_19295	COG0697	spore germination
B4U62_19300	COG0814	amino acid
B4U62_19310	COG2814	Major facilitator Superfamily
B4U62_19315	COG1316	TRANSCRIPTIONal
B4U62_19320	COG0561	phosphatase activity
B4U62_19325	COG0791	NLP P60 protein
B4U62_19335	COG2843	Capsule synthesis protein
B4U62_19345	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B4U62_19355	COG1609	Transcriptional regulator
B4U62_19360	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4U62_19365	COG1869	D-ribose catabolic process
B4U62_19370	COG1129	ABC transporter
B4U62_19375	COG1172	Belongs to the binding-protein-dependent transport system permease family
B4U62_19380	COG1879	ABC-type sugar transport system periplasmic component
B4U62_19385	COG3103	Sh3 type 3 domain protein
B4U62_19395	COG2249	NAD(P)H dehydrogenase (quinone) activity
B4U62_19400	COG3527	Alpha-acetolactate decarboxylase
B4U62_19405	COG0028	Belongs to the TPP enzyme family
B4U62_19410	COG0583	DNA-binding transcription factor activity
B4U62_19415	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B4U62_19430	COG5337	Spore coat protein CotH
B4U62_19440	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B4U62_19450	COG0405	Gamma-glutamyltransferase
B4U62_19455	COG1522	sequence-specific DNA binding
B4U62_19460	COG2059	Chromate
B4U62_19465	COG2059	Chromate
B4U62_19475	COG0655	NAD(P)H dehydrogenase (quinone) activity
B4U62_19480	COG0583	DNA-binding transcription factor activity
B4U62_19485	COG1515	deoxyribonuclease V activity
B4U62_19490	COG2849	repeat protein
B4U62_19495	COG5444	nuclease activity
B4U62_19515	COG3878	Protein conserved in bacteria
B4U62_19520	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B4U62_19525	COG4464	protein tyrosine phosphatase activity
B4U62_19530	COG0489	protein tyrosine kinase activity
B4U62_19535	COG3944	biosynthesis protein
B4U62_19545	COG4715	Zinc finger, swim domain protein
B4U62_19550	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B4U62_19560	COG0561	phosphatase activity
B4U62_19565	COG1349	DNA-binding transcription factor activity
B4U62_19570	COG0629	single-stranded DNA binding
B4U62_19585	COG3764	Sortase (surface protein transpeptidase)
B4U62_19590	COG0745	RESPONSE REGULATOR receiver
B4U62_19590	COG2972	Histidine kinase
B4U62_19595	COG1970	mechanosensitive ion channel activity
B4U62_19600	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B4U62_19605	COG0457	Tetratricopeptide repeat
B4U62_19610	COG4786	Flagellar basal body rod
B4U62_19615	COG4786	Flagellar basal body rod
B4U62_19620	COG1077	Cell shape determining protein MreB Mrl
B4U62_19625	COG1609	Transcriptional regulator
B4U62_19635	COG1846	Transcriptional regulator
B4U62_19640	COG2814	Major facilitator Superfamily
B4U62_19645	COG3420	alginic acid biosynthetic process
B4U62_19650	COG1953	Uracil, thiamine, allantoin
B4U62_19655	COG0477	Major facilitator Superfamily
B4U62_19660	COG1335	isochorismatase
B4U62_19670	COG0004	ammonium transporteR
B4U62_19675	COG0347	Belongs to the P(II) protein family
B4U62_19680	COG0671	phosphoesterase, PA-phosphatase related
B4U62_19690	COG0739	heme binding
B4U62_19695	COG1247	-acetyltransferase
B4U62_19710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4U62_19715	COG0789	Transcriptional regulator
B4U62_19725	COG2910	NAD(P)H-binding
B4U62_19730	COG1959	2 iron, 2 sulfur cluster binding
B4U62_19735	COG0804	urea catabolic process
B4U62_19740	COG0832	Belongs to the urease beta subunit family
B4U62_19745	COG0831	urea catabolic process
B4U62_19760	COG3237	CsbD-like
B4U62_19765	COG1994	Peptidase M50
B4U62_19770	COG0457	Tetratricopeptide repeat
B4U62_19780	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B4U62_19785	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B4U62_19795	COG2304	oxidoreductase activity
B4U62_19805	COG2304	oxidoreductase activity
B4U62_19810	COG2385	sporulation resulting in formation of a cellular spore
B4U62_19815	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B4U62_19825	COG4836	Membrane
B4U62_19835	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B4U62_19840	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B4U62_19845	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B4U62_19850	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B4U62_19855	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B4U62_19860	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B4U62_19865	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B4U62_19870	COG0356	it plays a direct role in the translocation of protons across the membrane
B4U62_19880	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B4U62_19885	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B4U62_19890	COG4475	Protein of unknown function (DUF436)
B4U62_19895	COG0698	ribose 5-phosphate isomerase
B4U62_19900	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B4U62_19905	COG1971	Probably functions as a manganese efflux pump
B4U62_19910	COG0009	L-threonylcarbamoyladenylate synthase
B4U62_19915	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B4U62_19935	COG2890	protein-(glutamine-N5) methyltransferase activity
B4U62_19940	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B4U62_19945	COG0346	lactoylglutathione lyase activity
B4U62_19950	COG0789	Transcriptional regulator
B4U62_19955	COG0679	Auxin Efflux Carrier
B4U62_19960	COG0281	malic enzyme
B4U62_19965	COG1435	thymidine kinase activity
B4U62_19970	COG0254	rRNA binding
B4U62_19975	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B4U62_19980	COG1494	fructose-1,6-bisphosphatase
B4U62_19985	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B4U62_19990	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B4U62_19995	COG0191	fructose-bisphosphate aldolase activity
B4U62_20000	COG2204	response regulator
B4U62_20005	COG4821	SIS domain
B4U62_20010	COG0504	CTP synthase activity
B4U62_20015	COG3343	RNA polymerase activity
B4U62_20020	COG1960	acyl-CoA dehydrogenase activity
B4U62_20025	COG2181	nitrate reductase activity
B4U62_20025	COG0247	lactate metabolic process
B4U62_20030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4U62_20035	COG4294	response to UV
B4U62_20045	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B4U62_20050	COG1132	(ABC) transporter
B4U62_20055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B4U62_20065	COG2181	nitrate reductase activity
B4U62_20070	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
B4U62_20075	COG1140	nitrate reductase beta subunit
B4U62_20080	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
B4U62_20085	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B4U62_20095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B4U62_20100	COG2223	nitrite transmembrane transporter activity
B4U62_20105	COG0018	arginyl-trna synthetase
B4U62_20110	COG4506	Protein conserved in bacteria
B4U62_20125	COG0535	radical SAM domain protein
B4U62_20135	COG1131	(ABC) transporter
B4U62_20140	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B4U62_20145	COG0612	Peptidase, M16
B4U62_20150	COG0612	Peptidase, M16
B4U62_20160	COG3391	amine dehydrogenase activity
B4U62_20165	COG3391	amine dehydrogenase activity
B4U62_20175	COG0457	Tetratricopeptide repeat
B4U62_20185	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B4U62_20190	COG0010	Belongs to the arginase family
B4U62_20195	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B4U62_20200	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B4U62_20215	COG1994	Peptidase M50
B4U62_20220	COG1942	4-Oxalocrotonate Tautomerase
B4U62_20225	COG1846	Transcriptional regulator
B4U62_20230	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B4U62_20235	COG0477	Major facilitator Superfamily
B4U62_20240	COG1959	2 iron, 2 sulfur cluster binding
B4U62_20245	COG3465	dGTPase activity
B4U62_20250	COG1078	dGTPase activity
B4U62_20255	COG4844	belongs to the
B4U62_20265	COG0697	spore germination
B4U62_20270	COG0095	Lipoate-protein ligase
B4U62_20275	COG0583	DNA-binding transcription factor activity
B4U62_20280	COG0280	phosphate acetyltransferase
B4U62_20290	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_20295	COG0436	Aminotransferase
B4U62_20300	COG2814	Major facilitator Superfamily
B4U62_20305	COG0151	Belongs to the GarS family
B4U62_20310	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_20315	COG1917	Cupin 2, conserved barrel domain protein
B4U62_20320	COG0077	Prephenate dehydratase
B4U62_20325	COG2814	Major facilitator Superfamily
B4U62_20330	COG0833	amino acid
B4U62_20335	COG4187	Peptidase family M20/M25/M40
B4U62_20340	COG1012	belongs to the aldehyde dehydrogenase family
B4U62_20345	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B4U62_20355	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
B4U62_20360	COG1091	dTDP-4-dehydrorhamnose reductase activity
B4U62_20365	COG1088	dTDP-glucose 4,6-dehydratase activity
B4U62_20370	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
B4U62_20375	COG3980	spore coat polysaccharide biosynthesis protein
B4U62_20380	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
B4U62_20385	COG2089	acid synthase
B4U62_20390	COG0456	acetyltransferase
B4U62_20395	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B4U62_20400	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B4U62_20405	COG0463	Glycosyl transferase, family 2
B4U62_20420	COG2363	Small membrane protein
B4U62_20425	COG2233	PERMEase
B4U62_20435	COG1012	belongs to the aldehyde dehydrogenase family
B4U62_20440	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B4U62_20445	COG1216	Glycosyl transferase, family 2
B4U62_20460	COG1695	Transcriptional regulator
B4U62_20465	COG0351	phosphomethylpyrimidine kinase
B4U62_20475	COG1621	beta-fructofuranosidase activity
B4U62_20480	COG1263	PTS System
B4U62_20480	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U62_20485	COG2116	formate transmembrane transporter activity
B4U62_20490	COG3711	transcriptional antiterminator
B4U62_20500	COG1404	Belongs to the peptidase S8 family
B4U62_20505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B4U62_20510	COG0778	Nitroreductase
B4U62_20515	COG0772	Belongs to the SEDS family
B4U62_20525	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B4U62_20530	COG1845	cytochrome c oxidase, subunit III
B4U62_20535	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B4U62_20540	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B4U62_20545	COG2261	transglycosylase associated protein
B4U62_20550	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
B4U62_20555	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B4U62_20560	COG2246	polysaccharide biosynthetic process
B4U62_20565	COG1309	transcriptional regulator
B4U62_20575	COG3162	membrane
B4U62_20580	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B4U62_20585	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B4U62_20590	COG2837	iron assimilation
B4U62_20595	COG2822	iron ion transport
B4U62_20600	COG0672	)-iron permease
B4U62_20605	COG0352	thiamine-phosphate diphosphorylase activity
B4U62_20610	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
B4U62_20615	COG0583	DNA-binding transcription factor activity
B4U62_20620	COG1380	Effector of murein hydrolase LrgA
B4U62_20625	COG1346	cytolysis
B4U62_20630	COG2814	Major facilitator Superfamily
B4U62_20635	COG4895	conserved protein (DUF2196)
B4U62_20640	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B4U62_20645	COG0346	lactoylglutathione lyase activity
B4U62_20655	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4U62_20660	COG1404	Belongs to the peptidase S8 family
B4U62_20665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U62_20665	COG1263	PTS System
B4U62_20670	COG3711	transcriptional antiterminator
B4U62_20675	COG1442	glycosyl transferase family 8
B4U62_20680	COG5522	Integral membrane protein (intg_mem_TP0381)
B4U62_20685	COG1846	Transcriptional regulator
B4U62_20690	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B4U62_20695	COG2234	aminopeptidase activity
B4U62_20700	COG2357	RelA SpoT domain protein
B4U62_20705	COG1575	Belongs to the MenA family. Type 1 subfamily
B4U62_20720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B4U62_20725	COG1696	Membrane protein involved in D-alanine export
B4U62_20730	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B4U62_20735	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
B4U62_20740	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
B4U62_20745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B4U62_20750	COG1486	melibiose metabolic process
B4U62_20755	COG1447	Phosphotransferase system cellobiose-specific component IIA
B4U62_20760	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4U62_20765	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B4U62_20770	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B4U62_20770	COG3711	transcriptional antiterminator
B4U62_20780	COG2094	Belongs to the DNA glycosylase MPG family
B4U62_20785	COG0753	catalase activity
B4U62_20790	COG2814	Major facilitator Superfamily
B4U62_20795	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B4U62_20800	COG1131	(ABC) transporter
B4U62_20820	COG1595	DNA-templated transcription, initiation
B4U62_20825	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B4U62_20830	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B4U62_20835	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B4U62_20840	COG4988	ABC transporter
B4U62_20845	COG1294	oxidase, subunit
B4U62_20850	COG1271	oxidase subunit
B4U62_20855	COG3493	citrate carrier protein
B4U62_20860	COG0501	Belongs to the peptidase M48B family
B4U62_20870	COG0726	polysaccharide deacetylase
B4U62_20875	COG3842	ATPase activity
B4U62_20880	COG2508	Transcriptional regulator
B4U62_20885	COG1012	belongs to the aldehyde dehydrogenase family
B4U62_20890	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B4U62_20900	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B4U62_20905	COG1881	PFAM PEBP family protein
B4U62_20910	COG0583	DNA-binding transcription factor activity
B4U62_20920	COG4585	Histidine kinase
B4U62_20925	COG2197	response regulator
B4U62_20930	COG2195	Cleaves the N-terminal amino acid of tripeptides
B4U62_20940	COG4894	glucomannan catabolic process
B4U62_20945	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B4U62_20950	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B4U62_20955	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_20960	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B4U62_20965	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B4U62_20970	COG2610	gluconate transmembrane transporter activity
B4U62_20975	COG0500	methyltransferase
B4U62_20980	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4U62_20995	COG0693	protein deglycase activity
B4U62_20995	COG0753	catalase activity
B4U62_21000	COG2851	Citrate transporter
B4U62_21005	COG2273	Hydrolase Family 16
B4U62_21010	COG3711	transcriptional antiterminator
B4U62_21020	COG2270	Major facilitator Superfamily
B4U62_21025	COG0513	Belongs to the DEAD box helicase family
B4U62_21030	COG3401	FG-GAP repeat protein
B4U62_21030	COG2755	lipolytic protein G-D-S-L family
B4U62_21090	COG3209	COG3209 Rhs family protein
B4U62_21095	COG0697	spore germination
B4U62_21100	COG0589	response to stress
B4U62_21105	COG2723	6-phospho-beta-galactosidase activity
B4U62_21110	COG1263	PTS System
B4U62_21110	COG2190	(PTS) system
B4U62_21110	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U62_21125	COG5444	nuclease activity
B4U62_21140	COG3507	Belongs to the glycosyl hydrolase 43 family
B4U62_21155	COG2986	histidine ammonia-lyase
B4U62_21160	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B4U62_21165	COG1228	amidohydrolase
B4U62_21170	COG0010	Belongs to the arginase family
B4U62_21175	COG0833	amino acid
B4U62_21180	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
B4U62_21185	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B4U62_21190	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B4U62_21195	COG2390	Transcriptional regulator
B4U62_21205	COG3192	ethanolamine utilization protein
B4U62_21210	COG2079	MmgE PrpD family protein
B4U62_21220	COG1126	abc transporter atp-binding protein
B4U62_21225	COG0765	amino acid transport
B4U62_21230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B4U62_21250	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
B4U62_21255	COG0561	phosphatase activity
B4U62_21285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B4U62_21290	COG5294	Protein conserved in bacteria
B4U62_21295	COG0577	efflux transmembrane transporter activity
B4U62_21300	COG1136	(ABC) transporter
B4U62_21305	COG2205	protein histidine kinase activity
B4U62_21310	COG0745	RESPONSE REGULATOR receiver
B4U62_21315	COG0191	fructose-bisphosphate aldolase activity
B4U62_21320	COG1082	Xylose isomerase domain protein TIM barrel
B4U62_21325	COG1082	Xylose isomerase domain protein TIM barrel
B4U62_21330	COG0673	inositol 2-dehydrogenase activity
B4U62_21335	COG2814	Major facilitator Superfamily
B4U62_21340	COG1082	Xylose isomerase domain protein TIM barrel
B4U62_21345	COG3962	Belongs to the TPP enzyme family
B4U62_21350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B4U62_21355	COG3718	enzyme involved in inositol metabolism
B4U62_21360	COG1012	belongs to the aldehyde dehydrogenase family
B4U62_21365	COG1349	DNA-binding transcription factor activity
B4U62_21370	COG0667	Aldo Keto reductase
B4U62_21385	COG2814	Major facilitator Superfamily
B4U62_21390	COG0326	Molecular chaperone. Has ATPase activity
B4U62_21400	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_21405	COG1309	transcriptional regulator
B4U62_21410	COG1012	belongs to the aldehyde dehydrogenase family
B4U62_21415	COG0456	acetyltransferase
B4U62_21420	COG2850	peptidyl-arginine hydroxylation
B4U62_21425	COG2226	methyltransferase
B4U62_21440	COG0367	asparagine synthase
B4U62_21445	COG2814	Major facilitator Superfamily
B4U62_21450	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B4U62_21460	COG1714	RDD family
B4U62_21465	COG2311	Membrane
B4U62_21470	COG1917	Cupin 2, conserved barrel domain protein
B4U62_21475	COG1309	transcriptional regulator
B4U62_21480	COG1028	Short-chain dehydrogenase reductase Sdr
B4U62_21485	COG1846	Transcriptional regulator
B4U62_21490	COG1380	Effector of murein hydrolase LrgA
B4U62_21495	COG1346	cytolysis
B4U62_21500	COG5039	Polysaccharide pyruvyl transferase
B4U62_21505	COG1929	Belongs to the glycerate kinase type-1 family
B4U62_21510	COG1802	Transcriptional regulator
B4U62_21515	COG1070	Carbohydrate kinase
B4U62_21520	COG2610	gluconate transmembrane transporter activity
B4U62_21525	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B4U62_21530	COG0450	alkyl hydroperoxide reductase
B4U62_21535	COG3634	alkyl hydroperoxide reductase activity
B4U62_21540	COG2723	6-phospho-beta-galactosidase activity
B4U62_21545	COG2190	(PTS) system
B4U62_21550	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B4U62_21550	COG2190	(PTS) system
B4U62_21550	COG1263	PTS System
B4U62_21555	COG2188	Transcriptional regulator
B4U62_21570	COG1131	(ABC) transporter
B4U62_21575	COG1994	Peptidase M50
B4U62_21580	COG0535	radical SAM domain protein
B4U62_21590	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
B4U62_21595	COG5293	efflux transmembrane transporter activity
B4U62_21605	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B4U62_21610	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B4U62_21625	COG1063	alcohol dehydrogenase
B4U62_21645	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
B4U62_21650	COG0456	acetyltransferase
B4U62_21655	COG0457	Tetratricopeptide repeat
B4U62_21665	COG0010	Belongs to the arginase family
B4U62_21670	COG0833	amino acid
B4U62_21675	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B4U62_21680	COG3829	transcription factor binding
B4U62_21685	COG5002	protein histidine kinase activity
B4U62_21695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B4U62_21700	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B4U62_21705	COG4853	Protein conserved in bacteria
B4U62_21710	COG4863	YycH protein
B4U62_21715	COG5002	protein histidine kinase activity
B4U62_21720	COG0745	RESPONSE REGULATOR receiver
B4U62_21750	COG0346	lactoylglutathione lyase activity
B4U62_21755	COG0305	Participates in initiation and elongation during chromosome replication
B4U62_21770	COG3093	addiction module antidote protein HigA
B4U62_21775	COG2807	transmembrane transport
B4U62_21780	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B4U62_21785	COG0359	binds to the 23S rRNA
B4U62_21790	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
B4U62_21795	COG4241	membrane
B4U62_21805	COG5577	PFAM Coat F domain
B4U62_21810	COG1733	regulation of RNA biosynthetic process
B4U62_21815	COG1227	inorganic diphosphatase activity
B4U62_21830	COG2271	Major facilitator Superfamily
B4U62_21870	COG1131	(ABC) transporter
B4U62_21880	COG4319	ketosteroid isomerase
B4U62_21885	COG1357	PFAM Pentapeptide repeats (8 copies)
B4U62_21890	COG2814	Major facilitator Superfamily
B4U62_21895	COG0583	DNA-binding transcription factor activity
B4U62_21900	COG2153	protein acetylation
B4U62_21910	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B4U62_21915	COG1846	Transcriptional regulator
B4U62_21920	COG2153	protein acetylation
B4U62_21925	COG2364	Membrane
B4U62_21930	COG0456	acetyltransferase
B4U62_21935	COG2315	Protein conserved in bacteria
B4U62_21940	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B4U62_21950	COG2814	Major facilitator Superfamily
B4U62_21955	COG1331	Highly conserved protein containing a thioredoxin domain
B4U62_21960	COG0789	Transcriptional regulator
B4U62_21965	COG0697	spore germination
B4U62_21970	COG1331	Highly conserved protein containing a thioredoxin domain
B4U62_21975	COG1266	CAAX protease self-immunity
B4U62_21980	COG2814	Major facilitator Superfamily
B4U62_21980	COG0477	Major facilitator Superfamily
B4U62_21985	COG0110	maltose O-acetyltransferase activity
B4U62_21990	COG0346	lactoylglutathione lyase activity
B4U62_21995	COG1609	Transcriptional regulator
B4U62_22000	COG0708	Exodeoxyribonuclease III
B4U62_22005	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B4U62_22010	COG0629	single-stranded DNA binding
B4U62_22015	COG0360	Binds together with S18 to 16S ribosomal RNA
B4U62_22020	COG0012	GTP binding
B4U62_22025	COG0243	molybdopterin cofactor binding
B4U62_22030	COG4481	Protein conserved in bacteria
B4U62_22035	COG3949	Membrane
B4U62_22045	COG1475	DNA binding
B4U62_22050	COG1192	Involved in chromosome partitioning
B4U62_22060	COG1475	DNA binding
B4U62_22065	COG0357	Ribosomal RNA small subunit methyltransferase G
B4U62_22070	COG0445	tRNA wobble uridine modification
B4U62_22075	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B4U62_22080	COG1847	R3H domain protein
B4U62_22085	COG0706	membrane insertase activity
B4U62_22090	COG0594	ribonuclease P activity
B4U62_22095	COG0230	Belongs to the bacterial ribosomal protein bL34 family
B4U62_22120	COG5444	nuclease activity
B4U62_22175	COG3953	SLT domain
B4U62_22175	COG5280	Phage tail tape measure protein TP901
B4U62_22265	COG0457	Tetratricopeptide repeat
B4U62_22285	COG3584	3D domain protein
B4U62_22285	COG1388	LysM domain
B4U62_22300	COG0582	viral genome integration into host DNA
B4U62_22370	COG2887	Belongs to the helicase family. UvrD subfamily
B4U62_22375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4U62_22380	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B4U62_22385	COG0716	FMN binding
B4U62_22425	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B4U62_22460	COG0328	RNA-DNA hybrid ribonuclease activity
B4U62_22480	COG0587	DNA-directed DNA polymerase activity
B4U62_22500	COG0194	GDP metabolic process
B4U62_22545	COG0187	DNA topoisomerase II activity
B4U62_22550	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner