locus-tag	class	description
GII89_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GII89_00010	COG0592	DNA-directed DNA polymerase activity
GII89_00015	COG2501	S4 domain
GII89_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GII89_00030	COG0187	DNA topoisomerase II activity
GII89_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GII89_00070	COG0516	GMP reductase activity
GII89_00070	COG0517	IMP dehydrogenase activity
GII89_00075	COG1686	Belongs to the peptidase S11 family
GII89_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GII89_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GII89_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GII89_00100	COG1428	Deoxynucleoside kinase
GII89_00105	COG1428	Deoxynucleoside kinase
GII89_00110	COG3858	chitin binding
GII89_00110	COG1388	LysM domain
GII89_00115	COG1335	isochorismatase
GII89_00120	COG0590	tRNA wobble adenosine to inosine editing
GII89_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GII89_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GII89_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GII89_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
GII89_00190	COG3853	Toxic anion resistance protein (TelA)
GII89_00195	COG1982	Orn Lys Arg decarboxylase major
GII89_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GII89_00205	COG3870	Protein conserved in bacteria
GII89_00210	COG1728	Protein conserved in bacteria
GII89_00215	COG0470	DNA polymerase III
GII89_00220	COG1774	PSP1 C-terminal conserved region
GII89_00225	COG4467	Involved in initiation control of chromosome replication
GII89_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GII89_00235	COG2827	Endonuclease containing a URI domain
GII89_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GII89_00245	COG2002	toxin-antitoxin pair type II binding
GII89_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GII89_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GII89_00255	COG0084	hydrolase, TatD family'
GII89_00260	COG3584	3D domain protein
GII89_00260	COG3583	domain protein
GII89_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GII89_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GII89_00280	COG4466	Protein conserved in bacteria
GII89_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GII89_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GII89_00300	COG0251	oxidation-reduction process
GII89_00305	COG2088	sporulation resulting in formation of a cellular spore
GII89_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GII89_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GII89_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GII89_00325	COG0193	aminoacyl-tRNA hydrolase activity
GII89_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GII89_00340	COG2002	toxin-antitoxin pair type II binding
GII89_00345	COG2244	polysaccharide biosynthetic process
GII89_00350	COG3956	TIGRFAM MazG family protein
GII89_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GII89_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GII89_00375	COG1098	S1 RNA binding domain
GII89_00390	COG2208	phosphoserine phosphatase activity
GII89_00395	COG2304	oxidoreductase activity
GII89_00400	COG0515	serine threonine protein kinase
GII89_00405	COG0037	tRNA processing
GII89_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GII89_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GII89_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GII89_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GII89_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GII89_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GII89_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
GII89_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GII89_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GII89_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GII89_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GII89_00470	COG1396	sequence-specific DNA binding
GII89_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GII89_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GII89_00560	COG4463	regulation of RNA biosynthetic process
GII89_00565	COG3880	PFAM UvrB UvrC protein
GII89_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GII89_00575	COG0542	response to heat
GII89_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GII89_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GII89_00590	COG4956	integral membrane protein (PIN domain superfamily)
GII89_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GII89_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GII89_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GII89_00610	COG1045	serine acetyltransferase
GII89_00615	COG0215	cysteine-tRNA ligase activity
GII89_00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GII89_00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GII89_00630	COG3688	RNA-binding protein containing a PIN domain
GII89_00635	COG1595	DNA-templated transcription, initiation
GII89_00640	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GII89_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GII89_00650	COG0250	Participates in transcription elongation, termination and antitermination
GII89_00655	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
GII89_00660	COG0081	regulation of translation
GII89_00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GII89_00670	COG0222	ribosome binding
GII89_00675	COG2813	Specifically methylates the guanine in position
GII89_00680	COG0085	RNA polymerase activity
GII89_00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GII89_00690	COG1358	cellular component organization or biogenesis
GII89_00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GII89_00700	COG0049	tRNA binding
GII89_00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GII89_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GII89_00715	COG0596	Alpha beta hydrolase
GII89_00720	COG0051	transcription antitermination factor activity, RNA binding
GII89_00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GII89_00730	COG0088	Forms part of the polypeptide exit tunnel
GII89_00735	COG0089	rRNA binding
GII89_00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GII89_00745	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
GII89_00750	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
GII89_00755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
GII89_00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GII89_00765	COG0255	Belongs to the universal ribosomal protein uL29 family
GII89_00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GII89_00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GII89_00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GII89_00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GII89_00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GII89_00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GII89_00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GII89_00815	COG1841	ribosomal large subunit assembly
GII89_00820	COG0200	Binds to the 23S rRNA
GII89_00825	COG0201	protein transport
GII89_00830	COG0563	adenylate kinase activity
GII89_00835	COG0024	Methionine aminopeptidase
GII89_00840	COG2163	COG2163 Ribosomal protein L14E L6E L27E
GII89_00845	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
GII89_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GII89_00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GII89_00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GII89_00865	COG0202	RNA polymerase activity
GII89_00870	COG0203	ribosomal protein L17
GII89_00875	COG1122	ATPase activity
GII89_00880	COG1122	ATPase activity
GII89_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GII89_00890	COG0101	tRNA pseudouridine synthase activity
GII89_00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GII89_00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GII89_00905	COG2226	methyltransferase
GII89_00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
GII89_00920	COG0489	protein tyrosine kinase activity
GII89_00930	COG2194	sulfuric ester hydrolase activity
GII89_00935	COG0726	polysaccharide deacetylase
GII89_01015	COG0659	secondary active sulfate transmembrane transporter activity
GII89_01020	COG0385	Bile acid
GII89_01025	COG2819	hydrolase of the alpha beta superfamily
GII89_01030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII89_01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII89_01040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GII89_01045	COG2207	Transcriptional regulator
GII89_01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GII89_01050	COG3876	Protein conserved in bacteria
GII89_01055	COG1472	Belongs to the glycosyl hydrolase 3 family
GII89_01060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GII89_01065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII89_01065	COG1263	PTS System
GII89_01070	COG1737	Transcriptional regulator
GII89_01075	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GII89_01080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GII89_01085	COG1683	Conserved Protein
GII89_01115	COG1595	DNA-templated transcription, initiation
GII89_01120	COG5662	AntiSigma factor
GII89_01125	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GII89_01130	COG4856	YbbR-like protein
GII89_01135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GII89_01140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GII89_01150	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GII89_01155	COG2169	Transcriptional regulator
GII89_01160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GII89_01165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GII89_01170	COG3002	Belongs to the UPF0753 family
GII89_01175	COG0288	reversible hydration of carbon dioxide
GII89_01185	COG5609	conserved protein (DUF2294)
GII89_01190	COG0640	Transcriptional regulator
GII89_01195	COG2814	Major facilitator Superfamily
GII89_01200	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GII89_01210	COG0535	radical SAM domain protein
GII89_01215	COG1266	CAAX protease self-immunity
GII89_01220	COG1131	(ABC) transporter
GII89_01230	COG1413	lyase activity
GII89_01235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII89_01240	COG0596	Alpha beta hydrolase
GII89_01245	COG0745	RESPONSE REGULATOR receiver
GII89_01250	COG0642	Histidine kinase
GII89_01260	COG0515	serine threonine protein kinase
GII89_01275	COG1113	amino acid transport
GII89_01290	COG2602	Beta-lactamase
GII89_01295	COG2124	cytochrome p450
GII89_01305	COG0531	amino acid
GII89_01310	COG0584	glycerophosphoryl diester phosphodiesterase
GII89_01315	COG2271	Major facilitator Superfamily
GII89_01325	COG0456	acetyltransferase
GII89_01325	COG1846	Transcriptional regulator
GII89_01330	COG2271	Major facilitator Superfamily
GII89_01345	COG3409	Peptidoglycan-binding domain 1 protein
GII89_01350	COG0697	spore germination
GII89_01355	COG2207	Transcriptional regulator
GII89_01355	COG1917	Cupin 2, conserved barrel domain protein
GII89_01360	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GII89_01365	COG3591	Belongs to the peptidase S1B family
GII89_01375	COG0596	Alpha beta hydrolase
GII89_01380	COG1183	phosphatidylcholine synthase activity
GII89_01385	COG0586	Pfam SNARE associated Golgi protein
GII89_01390	COG0688	phosphatidylethanolamine metabolic process
GII89_01400	COG2312	Erythromycin esterase
GII89_01405	COG2207	Transcriptional regulator
GII89_01415	COG1301	dicarboxylic acid transport
GII89_01420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII89_01420	COG1263	PTS System
GII89_01420	COG2190	(PTS) system
GII89_01425	COG0363	glucosamine-6-phosphate deaminase activity
GII89_01440	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GII89_01445	COG0833	amino acid
GII89_01450	COG2040	homocysteine
GII89_01460	COG1115	amino acid carrier protein
GII89_01465	COG2066	Belongs to the glutaminase family
GII89_01470	COG4191	Histidine kinase
GII89_01475	COG0784	Response regulator, receiver
GII89_01480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GII89_01485	COG1012	belongs to the aldehyde dehydrogenase family
GII89_01490	COG2271	Major facilitator Superfamily
GII89_01495	COG4948	Mandelate Racemase Muconate Lactonizing
GII89_01500	COG2186	Transcriptional regulator
GII89_01505	COG2721	sulfolactate sulfo-lyase activity
GII89_01510	COG3173	Aminoglycoside phosphotransferase
GII89_01520	COG0697	spore germination
GII89_01525	COG0745	RESPONSE REGULATOR receiver
GII89_01530	COG2205	protein histidine kinase activity
GII89_01535	COG1131	(ABC) transporter
GII89_01555	COG3773	Cell wall hydrolase
GII89_01560	COG2304	oxidoreductase activity
GII89_01570	COG3540	Alkaline phosphatase
GII89_01575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GII89_01580	COG0805	protein transport
GII89_01585	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GII89_01590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GII89_01595	COG0477	Major facilitator Superfamily
GII89_01600	COG1309	transcriptional regulator
GII89_01605	COG0252	asparaginase activity
GII89_01610	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GII89_01615	COG1714	RDD family
GII89_01620	COG1405	negative regulation of cell septum assembly
GII89_01620	COG3012	SEC-C Motif Domain Protein
GII89_01625	COG3290	protein histidine kinase activity
GII89_01630	COG3279	Response regulator of the LytR AlgR family
GII89_01635	COG4555	ABC transporter
GII89_01640	COG1668	transmembrane transport
GII89_01645	COG0667	Aldo Keto reductase
GII89_01660	COG1595	DNA-templated transcription, initiation
GII89_01665	COG1595	DNA-templated transcription, initiation
GII89_01670	COG1876	peptidase activity
GII89_01675	COG0457	Tetratricopeptide repeat
GII89_01680	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_01685	COG0366	Alpha amylase catalytic
GII89_01690	COG0803	Belongs to the bacterial solute-binding protein 9 family
GII89_01695	COG1121	(ABC) transporter
GII89_01700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GII89_01705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GII89_01715	COG2310	stress, protein
GII89_01720	COG2310	stress, protein
GII89_01725	COG0861	Integral membrane protein TerC family
GII89_01735	COG3853	Toxic anion resistance protein (TelA)
GII89_01740	COG0477	Major facilitator Superfamily
GII89_01745	COG2814	Major facilitator Superfamily
GII89_01750	COG0640	Transcriptional regulator
GII89_01755	COG0517	IMP dehydrogenase activity
GII89_01755	COG4175	Glycine betaine
GII89_01760	COG4176	ABC-type proline glycine betaine transport system permease component
GII89_01765	COG2113	Glycine betaine
GII89_01770	COG1473	amidohydrolase
GII89_01775	COG1288	antiporter activity
GII89_01785	COG0366	Alpha amylase catalytic
GII89_01790	COG0039	L-malate dehydrogenase activity
GII89_01795	COG1620	l-lactate permease
GII89_01800	COG2814	Major facilitator Superfamily
GII89_01805	COG1846	Transcriptional regulator
GII89_01810	COG1280	lysine exporter protein (LysE YggA)
GII89_01815	COG3403	YqcI/YcgG family
GII89_01820	COG1113	amino acid transport
GII89_01825	COG3665	Urea carboxylase-associated protein
GII89_01830	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GII89_01835	COG1660	Displays ATPase and GTPase activities
GII89_01840	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GII89_01845	COG2226	methyltransferase
GII89_01850	COG0583	DNA-binding transcription factor activity
GII89_01855	COG3458	cephalosporin-C deacetylase activity
GII89_01860	COG3541	Predicted nucleotidyltransferase
GII89_01865	COG0506	proline dehydrogenase activity
GII89_01870	COG1012	belongs to the aldehyde dehydrogenase family
GII89_01875	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GII89_01880	COG2508	Transcriptional regulator
GII89_01885	COG3689	TIGRFAM TIGR03943 family protein
GII89_01890	COG0701	Predicted permease
GII89_01895	COG2267	carboxylic ester hydrolase activity
GII89_01900	COG0492	ferredoxin-NADP+ reductase activity
GII89_01905	COG1587	Uroporphyrinogen-III synthase
GII89_01905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GII89_01910	COG2146	nitrite reductase [NAD(P)H] activity
GII89_01915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GII89_01920	COG0243	molybdopterin cofactor binding
GII89_01925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GII89_01930	COG2223	nitrite transmembrane transporter activity
GII89_01935	COG1469	GTP cyclohydrolase I activity
GII89_01940	COG1376	ErfK ybiS ycfS ynhG family protein
GII89_01950	COG0523	cobalamin synthesis protein
GII89_01955	COG0765	amino acid transport
GII89_01960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GII89_01970	COG1714	RDD family
GII89_01980	COG2723	6-phospho-beta-galactosidase activity
GII89_01990	COG3209	COG3209 Rhs family protein
GII89_01995	COG0840	transmembrane signaling receptor activity
GII89_01995	COG3290	protein histidine kinase activity
GII89_02000	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GII89_02005	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GII89_02010	COG1733	regulation of RNA biosynthetic process
GII89_02015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII89_02020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII89_02025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII89_02030	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
GII89_02035	COG2814	Major facilitator Superfamily
GII89_02045	COG0697	spore germination
GII89_02050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GII89_02060	COG2364	Membrane
GII89_02065	COG1126	abc transporter atp-binding protein
GII89_02070	COG0765	amino acid transport
GII89_02075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GII89_02080	COG0583	DNA-binding transcription factor activity
GII89_02085	COG0163	prenyltransferase activity
GII89_02090	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GII89_02105	COG0596	Alpha beta hydrolase
GII89_02110	COG3104	oligopeptide transport
GII89_02115	COG5434	Belongs to the glycosyl hydrolase 28 family
GII89_02125	COG0697	spore germination
GII89_02135	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GII89_02140	COG1136	(ABC) transporter
GII89_02145	COG0577	efflux transmembrane transporter activity
GII89_02150	COG0745	RESPONSE REGULATOR receiver
GII89_02155	COG5002	protein histidine kinase activity
GII89_02155	COG3850	Histidine kinase
GII89_02160	COG0457	Tetratricopeptide repeat
GII89_02180	COG0527	aspartate kinase activity
GII89_02185	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII89_02190	COG4605	iron ion homeostasis
GII89_02195	COG4604	ABC transporter, ATP-binding protein
GII89_02200	COG4607	ABC-type enterochelin transport system periplasmic component
GII89_02205	COG2814	Major facilitator Superfamily
GII89_02210	COG1309	transcriptional regulator
GII89_02215	COG0778	Nitroreductase
GII89_02220	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GII89_02225	COG0640	Transcriptional regulator
GII89_02230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GII89_02235	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GII89_02240	COG1012	belongs to the aldehyde dehydrogenase family
GII89_02245	COG4975	Glucose uptake
GII89_02250	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_02255	COG4549	nuclear export factor GLE1
GII89_02260	COG2372	response to copper ion
GII89_02260	COG1276	copper resistance
GII89_02265	COG1349	DNA-binding transcription factor activity
GII89_02275	COG2213	PTS system mannitol-specific
GII89_02280	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII89_02285	COG0246	Mannitol dehydrogenase
GII89_02290	COG0473	3-isopropylmalate dehydrogenase activity
GII89_02295	COG0681	Belongs to the peptidase S26 family
GII89_02300	COG0412	Dienelactone hydrolase
GII89_02305	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GII89_02315	COG0561	phosphatase activity
GII89_02320	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GII89_02325	COG1914	H( )-stimulated, divalent metal cation uptake system
GII89_02330	COG4336	lyase activity
GII89_02335	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GII89_02340	COG1984	allophanate hydrolase subunit 2
GII89_02345	COG1414	Transcriptional regulator
GII89_02350	COG2755	lipolytic protein G-D-S-L family
GII89_02360	COG2329	Antibiotic biosynthesis monooxygenase
GII89_02365	COG0768	penicillin binding
GII89_02370	COG4989	oxidoreductase activity
GII89_02375	COG3711	transcriptional antiterminator
GII89_02380	COG0318	PFAM AMP-dependent synthetase and ligase
GII89_02385	COG2226	methyltransferase
GII89_02390	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_02395	COG1917	Cupin 2, conserved barrel domain protein
GII89_02400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GII89_02405	COG3871	stress protein (general stress protein 26)
GII89_02415	COG2814	Major facilitator Superfamily
GII89_02420	COG1522	sequence-specific DNA binding
GII89_02425	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GII89_02425	COG0551	DNA topoisomerase type I activity
GII89_02430	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GII89_02435	COG3706	GGDEF domain
GII89_02440	COG5298	Protein conserved in bacteria
GII89_02445	COG1215	transferase activity, transferring glycosyl groups
GII89_02455	COG0531	amino acid
GII89_02460	COG0494	nUDIX hydrolase
GII89_02465	COG0028	Belongs to the TPP enzyme family
GII89_02480	COG1914	H( )-stimulated, divalent metal cation uptake system
GII89_02485	COG2261	transglycosylase associated protein
GII89_02490	COG4876	unkown
GII89_02495	COG2217	Heavy metal translocating P-type atpase
GII89_02500	COG3729	General stress protein
GII89_02505	COG0662	Cupin 2, conserved barrel domain protein
GII89_02510	COG2329	Antibiotic biosynthesis monooxygenase
GII89_02515	COG3546	catalase activity
GII89_02520	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GII89_02525	COG3290	protein histidine kinase activity
GII89_02530	COG4565	transcriptional regulatory protein
GII89_02535	COG1301	dicarboxylic acid transport
GII89_02540	COG0628	permease
GII89_02545	COG1131	(ABC) transporter
GII89_02550	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GII89_02560	COG1960	acyl-CoA dehydrogenase activity
GII89_02575	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GII89_02580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII89_02585	COG1181	Belongs to the D-alanine--D-alanine ligase family
GII89_02590	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GII89_02595	COG0513	Belongs to the DEAD box helicase family
GII89_02600	COG3402	PFAM membrane-flanked domain
GII89_02605	COG3428	Bacterial PH domain
GII89_02610	COG0705	Rhomboid family
GII89_02615	COG0736	holo-[acyl-carrier-protein] synthase activity
GII89_02620	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GII89_02625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GII89_02630	COG0864	Transcriptional regulator
GII89_02635	COG2337	Toxic component of a toxin-antitoxin (TA) module
GII89_02640	COG1366	Belongs to the anti-sigma-factor antagonist family
GII89_02645	COG1366	Belongs to the anti-sigma-factor antagonist family
GII89_02650	COG2172	sigma factor antagonist activity
GII89_02655	COG2208	phosphoserine phosphatase activity
GII89_02660	COG1366	Belongs to the anti-sigma-factor antagonist family
GII89_02665	COG2172	sigma factor antagonist activity
GII89_02670	COG1191	sigma factor activity
GII89_02675	COG2208	phosphoserine phosphatase activity
GII89_02690	COG1673	EVE domain
GII89_02695	COG1846	Transcriptional regulator
GII89_02700	COG2183	response to ionizing radiation
GII89_02710	COG3091	SprT-like family
GII89_02750	COG0582	viral genome integration into host DNA
GII89_02755	COG2856	Zn peptidase
GII89_02760	COG1396	sequence-specific DNA binding
GII89_02790	COG1674	ftsk spoiiie
GII89_02795	COG2946	Replication initiation factor
GII89_02830	COG0433	COG0433 Predicted ATPase
GII89_02840	COG5644	endopeptidase inhibitor activity
GII89_02845	COG0741	lytic transglycosylase activity
GII89_02845	COG0791	NLP P60 protein
GII89_02865	COG0457	Tetratricopeptide repeat
GII89_02880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GII89_02885	COG1522	sequence-specific DNA binding
GII89_02890	COG1522	sequence-specific DNA binding
GII89_02895	COG1335	isochorismatase
GII89_02900	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GII89_02905	COG2814	Major facilitator Superfamily
GII89_02925	COG0693	protein deglycase activity
GII89_02930	COG1278	Cold shock
GII89_02935	COG1329	Transcriptional regulator
GII89_02945	COG2207	Transcriptional regulator
GII89_02945	COG1917	Cupin 2, conserved barrel domain protein
GII89_02950	COG0697	spore germination
GII89_02955	COG2207	Transcriptional regulator
GII89_02955	COG3708	Transcriptional regulator
GII89_02960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GII89_02965	COG0477	Major facilitator Superfamily
GII89_02975	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
GII89_02985	COG0697	spore germination
GII89_02990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GII89_02995	COG2030	dehydratase
GII89_03000	COG3545	Serine hydrolase
GII89_03005	COG1733	regulation of RNA biosynthetic process
GII89_03010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GII89_03015	COG1733	regulation of RNA biosynthetic process
GII89_03020	COG2249	NAD(P)H dehydrogenase (quinone) activity
GII89_03025	COG2814	Major facilitator Superfamily
GII89_03030	COG1309	transcriptional regulator
GII89_03040	COG0640	Transcriptional regulator
GII89_03045	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GII89_03055	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GII89_03060	COG0697	spore germination
GII89_03065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GII89_03070	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GII89_03075	COG0640	Transcriptional regulator
GII89_03080	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GII89_03095	COG4585	Histidine kinase
GII89_03100	COG2197	response regulator
GII89_03105	COG2409	Drug exporters of the RND superfamily
GII89_03110	COG0596	Alpha beta hydrolase
GII89_03115	COG1811	Na channel or pump
GII89_03120	COG4978	Transcriptional regulator
GII89_03120	COG0789	Transcriptional regulator
GII89_03125	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GII89_03130	COG0778	Nitroreductase
GII89_03135	COG0346	lactoylglutathione lyase activity
GII89_03140	COG2259	Doxx family
GII89_03145	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII89_03160	COG2323	membrane
GII89_03165	COG2323	membrane
GII89_03170	COG0071	Belongs to the small heat shock protein (HSP20) family
GII89_03185	COG1309	transcriptional regulator
GII89_03195	COG0456	acetyltransferase
GII89_03205	COG1113	amino acid transport
GII89_03210	COG2318	DinB family
GII89_03215	COG1846	Transcriptional regulator
GII89_03220	COG1033	growth of symbiont in host cell
GII89_03220	COG2409	Drug exporters of the RND superfamily
GII89_03225	COG0778	Nitroreductase
GII89_03230	COG1846	Transcriptional regulator
GII89_03235	COG2814	Major facilitator Superfamily
GII89_03240	COG0730	response to heat
GII89_03245	COG1802	Transcriptional regulator
GII89_03250	COG1388	LysM domain
GII89_03250	COG3858	chitin binding
GII89_03255	COG1819	glycosyl
GII89_03265	COG1785	Belongs to the alkaline phosphatase family
GII89_03270	COG5646	InterPro IPR014922
GII89_03280	COG0454	-acetyltransferase
GII89_03285	COG1078	dGTPase activity
GII89_03290	COG1388	LysM domain
GII89_03295	COG2814	Major facilitator Superfamily
GII89_03300	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GII89_03305	COG1447	Phosphotransferase system cellobiose-specific component IIA
GII89_03310	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GII89_03315	COG2723	6-phospho-beta-galactosidase activity
GII89_03320	COG2188	Transcriptional regulator
GII89_03325	COG1940	carbohydrate kinase activity
GII89_03330	COG1482	cell wall glycoprotein biosynthetic process
GII89_03335	COG4124	Belongs to the glycosyl hydrolase 26 family
GII89_03380	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GII89_03385	COG0802	atpase or kinase
GII89_03390	COG1214	PFAM Peptidase M22, glycoprotease
GII89_03395	COG0456	acetyltransferase
GII89_03400	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GII89_03405	COG0488	(ABC) transporter
GII89_03410	COG0315	cyclic pyranopterin monophosphate synthase activity
GII89_03415	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GII89_03420	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GII89_03425	COG0805	protein transport
GII89_03435	COG1266	CAAX protease self-immunity
GII89_03440	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
GII89_03445	COG0459	protein refolding
GII89_03455	COG3378	Phage plasmid primase P4 family
GII89_03470	COG0270	DNA (cytosine-5-)-methyltransferase activity
GII89_03475	COG0270	DNA (cytosine-5-)-methyltransferase activity
GII89_03495	COG1401	restriction endodeoxyribonuclease activity
GII89_03510	COG1073	alpha beta
GII89_03515	COG0457	Tetratricopeptide repeat
GII89_03520	COG1063	alcohol dehydrogenase
GII89_03525	COG2211	Major facilitator Superfamily
GII89_03530	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GII89_03535	COG1842	Phage shock protein A
GII89_03540	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GII89_03545	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GII89_03550	COG4260	virion core protein, lumpy skin disease virus
GII89_03560	COG2814	Major facilitator Superfamily
GII89_03565	COG1063	alcohol dehydrogenase
GII89_03570	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GII89_03575	COG0823	Involved in the tonB-independent uptake of proteins
GII89_03590	COG2267	carboxylic ester hydrolase activity
GII89_03600	COG2132	Multicopper oxidase
GII89_03605	COG1113	amino acid transport
GII89_03615	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GII89_03620	COG0714	Associated with various cellular activities
GII89_03625	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
GII89_03630	COG1305	Transglutaminase-like
GII89_03635	COG0519	Catalyzes the synthesis of GMP from XMP
GII89_03635	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GII89_03640	COG2252	PERMEase
GII89_03645	COG3064	Membrane
GII89_03655	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
GII89_03665	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GII89_03670	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GII89_03675	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GII89_03680	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GII89_03685	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GII89_03690	COG0047	phosphoribosylformylglycinamidine synthase activity
GII89_03695	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GII89_03700	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GII89_03705	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GII89_03710	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GII89_03715	COG0138	bifunctional purine biosynthesis protein purh
GII89_03720	COG0151	Belongs to the GarS family
GII89_03725	COG1522	sequence-specific DNA binding
GII89_03730	COG0531	amino acid
GII89_03740	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GII89_03745	COG1470	cell adhesion involved in biofilm formation
GII89_03750	COG4496	protein, YerC YecD
GII89_03755	COG0069	glutamate synthase activity
GII89_03760	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GII89_03765	COG0210	DNA helicase
GII89_03770	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GII89_03775	COG4851	CamS sex pheromone cAM373 precursor
GII89_03780	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GII89_03785	COG1285	pathogenesis
GII89_03790	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GII89_03795	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GII89_03800	COG0154	amidase activity
GII89_03805	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GII89_03810	COG1309	transcriptional regulator
GII89_03815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GII89_03820	COG1597	lipid kinase activity
GII89_03825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GII89_03830	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GII89_03835	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GII89_03840	COG1002	Type II restriction enzyme, methylase subunits
GII89_03845	COG1061	Type III restriction enzyme res subunit
GII89_03850	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GII89_03870	COG5444	nuclease activity
GII89_03875	COG3391	amine dehydrogenase activity
GII89_03880	COG0457	Tetratricopeptide repeat
GII89_03890	COG0217	transcriptional regulatory protein
GII89_03900	COG1309	transcriptional regulator
GII89_03905	COG3631	Ketosteroid isomerase-related protein
GII89_03910	COG0702	epimerase
GII89_03925	COG3546	catalase activity
GII89_03930	COG0454	-acetyltransferase
GII89_03940	COG5578	integral membrane protein
GII89_03945	COG2972	Histidine kinase
GII89_03950	COG2207	Transcriptional regulator
GII89_03950	COG4753	response regulator
GII89_03955	COG1653	transport
GII89_03960	COG1175	transmembrane transport
GII89_03965	COG0395	ABC-type sugar transport system, permease component
GII89_03970	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GII89_03975	COG2207	Transcriptional regulator
GII89_03980	COG2755	lipolytic protein G-D-S-L family
GII89_03990	COG5578	integral membrane protein
GII89_03995	COG3401	FG-GAP repeat protein
GII89_04000	COG3401	FG-GAP repeat protein
GII89_04005	COG2755	lipolytic protein G-D-S-L family
GII89_04010	COG1874	Beta-galactosidase
GII89_04020	COG1653	transport
GII89_04025	COG4209	transmembrane transport
GII89_04030	COG0395	ABC-type sugar transport system, permease component
GII89_04035	COG1486	melibiose metabolic process
GII89_04040	COG2323	membrane
GII89_04045	COG2329	Antibiotic biosynthesis monooxygenase
GII89_04050	COG0346	lactoylglutathione lyase activity
GII89_04065	COG5583	Uncharacterized small protein (DUF2292)
GII89_04070	COG0670	Belongs to the BI1 family
GII89_04075	COG0697	spore germination
GII89_04080	COG1846	Transcriptional regulator
GII89_04085	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GII89_04095	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GII89_04095	COG2124	cytochrome p450
GII89_04100	COG1368	sulfuric ester hydrolase activity
GII89_04105	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GII89_04110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GII89_04115	COG1442	glycosyl transferase family 8
GII89_04120	COG1216	Glycosyl transferase, family 2
GII89_04125	COG1442	glycosyl transferase family 8
GII89_04130	COG2223	nitrite transmembrane transporter activity
GII89_04135	COG1011	Hydrolase
GII89_04140	COG0531	amino acid
GII89_04145	COG1012	belongs to the aldehyde dehydrogenase family
GII89_04150	COG0840	transmembrane signaling receptor activity
GII89_04155	COG0488	(ABC) transporter
GII89_04165	COG0789	Transcriptional regulator
GII89_04170	COG2814	Major facilitator Superfamily
GII89_04180	COG0488	(ABC) transporter
GII89_04185	COG0513	Belongs to the DEAD box helicase family
GII89_04190	COG0456	acetyltransferase
GII89_04195	COG2130	NADP-dependent
GII89_04200	COG2211	Major facilitator Superfamily
GII89_04205	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GII89_04210	COG1120	ATPase activity
GII89_04215	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII89_04220	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII89_04225	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GII89_04240	COG3866	Pectate lyase
GII89_04245	COG0471	metal ion transport
GII89_04250	COG3290	protein histidine kinase activity
GII89_04255	COG4565	transcriptional regulatory protein
GII89_04260	COG3181	Tripartite tricarboxylate transporter family receptor
GII89_04265	COG2851	Citrate transporter
GII89_04270	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GII89_04275	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
GII89_04280	COG1254	Belongs to the acylphosphatase family
GII89_04285	COG2258	MOSC domain
GII89_04305	COG0024	Methionine aminopeptidase
GII89_04310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII89_04310	COG1263	PTS System
GII89_04315	COG1368	sulfuric ester hydrolase activity
GII89_04330	COG1115	amino acid carrier protein
GII89_04335	COG0531	amino acid
GII89_04350	COG0697	spore germination
GII89_04355	COG1263	PTS System
GII89_04355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII89_04360	COG0366	Alpha amylase catalytic
GII89_04365	COG2188	Transcriptional regulator
GII89_04370	COG0778	Nitroreductase
GII89_04375	COG0737	Belongs to the 5'-nucleotidase family
GII89_04380	COG0693	protein deglycase activity
GII89_04385	COG2814	Major facilitator Superfamily
GII89_04390	COG4840	Belongs to the UPF0435 family
GII89_04395	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GII89_04400	COG4980	gas vesicle protein
GII89_04405	COG1295	ribonuclease BN
GII89_04410	COG0477	Major facilitator Superfamily
GII89_04420	COG0387	Pfam Sodium calcium exchanger
GII89_04430	COG0668	transmembrane transport
GII89_04435	COG0535	radical SAM domain protein
GII89_04445	COG0726	polysaccharide deacetylase
GII89_04450	COG2084	Dehydrogenase
GII89_04455	COG0598	Magnesium transport protein CorA
GII89_04460	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GII89_04465	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GII89_04475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GII89_04480	COG4637	Psort location Cytoplasmic, score
GII89_04490	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GII89_04495	COG0022	dehydrogenase e1 component
GII89_04500	COG0508	dehydrogenase complex catalyzes the overall conversion of
GII89_04505	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GII89_04510	COG3284	Transcriptional regulator
GII89_04520	COG1742	UPF0060 membrane protein
GII89_04545	COG4842	Belongs to the WXG100 family
GII89_04550	COG1486	melibiose metabolic process
GII89_04555	COG1737	Transcriptional regulator
GII89_04560	COG1263	PTS System
GII89_04560	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII89_04565	COG1132	(ABC) transporter
GII89_04570	COG1132	(ABC) transporter
GII89_04575	COG2259	Doxx family
GII89_04580	COG2514	catechol 2,3-dioxygenase activity
GII89_04585	COG1917	Cupin 2, conserved barrel domain protein
GII89_04585	COG4977	sequence-specific DNA binding
GII89_04590	COG2814	Major facilitator Superfamily
GII89_04595	COG1082	Xylose isomerase domain protein TIM barrel
GII89_04600	COG0673	inositol 2-dehydrogenase activity
GII89_04605	COG4585	Histidine kinase
GII89_04610	COG2197	response regulator
GII89_04615	COG1131	(ABC) transporter
GII89_04620	COG1511	domain protein
GII89_04620	COG0842	Transport permease protein
GII89_04625	COG0842	Transport permease protein
GII89_04630	COG1695	Transcriptional regulator
GII89_04635	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GII89_04640	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
GII89_04645	COG1309	transcriptional regulator
GII89_04650	COG2814	Major facilitator Superfamily
GII89_04655	COG2318	DinB family
GII89_04660	COG2814	Major facilitator Superfamily
GII89_04665	COG1846	Transcriptional regulator
GII89_04670	COG0392	lysyltransferase activity
GII89_04670	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GII89_04675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GII89_04680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII89_04685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII89_04690	COG0384	phenazine biosynthesis protein PhzF
GII89_04695	COG0778	Nitroreductase
GII89_04710	COG1090	epimerase
GII89_04715	COG2137	regulation of response to DNA damage stimulus
GII89_04725	COG2814	Major facilitator Superfamily
GII89_04740	COG3103	Sh3 type 3 domain protein
GII89_04745	COG5658	integral membrane protein
GII89_04750	COG0596	Alpha beta hydrolase
GII89_04755	COG0463	Glycosyl transferase, family 2
GII89_04760	COG4485	Bacterial membrane protein, YfhO
GII89_04765	COG1988	membrane-bound metal-dependent
GII89_04770	COG1194	a g-specific adenine glycosylase
GII89_04780	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_04795	COG3557	Belongs to the UPF0374 family
GII89_04800	COG1132	(ABC) transporter
GII89_04805	COG4129	membrane
GII89_04810	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GII89_04815	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GII89_04820	COG0735	belongs to the Fur family
GII89_04930	COG4326	sporulation control protein
GII89_04940	COG5577	PFAM Coat F domain
GII89_04945	COG3340	Belongs to the peptidase S51 family
GII89_04950	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GII89_04955	COG0277	FAD linked oxidase domain protein
GII89_04965	COG0753	catalase activity
GII89_04970	COG1116	anion transmembrane transporter activity
GII89_04975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GII89_04980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GII89_04985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GII89_04995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GII89_05005	COG1476	TRANSCRIPTIONal
GII89_05015	COG3382	B3 4 domain protein
GII89_05020	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GII89_05030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GII89_05035	COG0789	Transcriptional regulator
GII89_05040	COG1664	Polymer-forming cytoskeletal
GII89_05045	COG1664	Polymer-forming cytoskeletal
GII89_05050	COG2766	serine protein kinase
GII89_05055	COG2718	Belongs to the UPF0229 family
GII89_05060	COG1846	Transcriptional regulator
GII89_05065	COG1566	PFAM secretion protein HlyD family protein
GII89_05070	COG2814	Major facilitator Superfamily
GII89_05075	COG0655	NAD(P)H dehydrogenase (quinone) activity
GII89_05095	COG1725	Transcriptional regulator
GII89_05100	COG1131	(ABC) transporter
GII89_05105	COG1131	(ABC) transporter
GII89_05110	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GII89_05115	COG1278	Cold shock
GII89_05120	COG1464	Belongs to the NlpA lipoprotein family
GII89_05125	COG3706	GGDEF domain
GII89_05130	COG1823	symporter activity
GII89_05150	COG5577	PFAM Coat F domain
GII89_05155	COG4085	toxin activity
GII89_05155	COG1525	nuclease
GII89_05155	COG0737	Belongs to the 5'-nucleotidase family
GII89_05160	COG3764	Sortase (surface protein transpeptidase)
GII89_05165	COG0564	pseudouridine synthase activity
GII89_05175	COG0517	IMP dehydrogenase activity
GII89_05180	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GII89_05185	COG3153	acetyltransferase
GII89_05185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GII89_05190	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GII89_05195	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GII89_05200	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GII89_05205	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GII89_05210	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GII89_05215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GII89_05220	COG4585	Histidine kinase
GII89_05220	COG2203	Gaf domain
GII89_05225	COG2197	response regulator
GII89_05230	COG0431	NADPH-dependent FMN reductase
GII89_05245	COG1388	LysM domain
GII89_05245	COG0791	NLP P60 protein
GII89_05250	COG1959	2 iron, 2 sulfur cluster binding
GII89_05255	COG0668	transmembrane transport
GII89_05260	COG2719	SpoVR family
GII89_05265	COG1785	Belongs to the alkaline phosphatase family
GII89_05270	COG0791	NLP P60 protein
GII89_05270	COG1388	LysM domain
GII89_05275	COG0583	DNA-binding transcription factor activity
GII89_05280	COG0372	Belongs to the citrate synthase family
GII89_05285	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_05290	COG0531	amino acid
GII89_05295	COG0733	neurotransmitter:sodium symporter activity
GII89_05300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GII89_05305	COG0456	acetyltransferase
GII89_05320	COG1595	DNA-templated transcription, initiation
GII89_05325	COG0667	Aldo Keto reductase
GII89_05330	COG0204	Acyl-transferase
GII89_05335	COG1253	flavin adenine dinucleotide binding
GII89_05340	COG0789	Transcriptional regulator
GII89_05345	COG0436	Aminotransferase
GII89_05350	COG1253	flavin adenine dinucleotide binding
GII89_05355	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GII89_05360	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GII89_05365	COG0584	glycerophosphoryl diester phosphodiesterase
GII89_05375	COG0668	transmembrane transport
GII89_05380	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GII89_05385	COG0726	polysaccharide deacetylase
GII89_05390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GII89_05395	COG1757	Na H antiporter
GII89_05400	COG0589	response to stress
GII89_05410	COG1132	(ABC) transporter
GII89_05415	COG1132	(ABC) transporter
GII89_05420	COG0702	epimerase
GII89_05440	COG0189	ligase activity
GII89_05445	COG0189	ligase activity
GII89_05450	COG4399	Belongs to the UPF0754 family
GII89_05455	COG3679	Belongs to the UPF0342 family
GII89_05460	COG4335	DNA alkylation repair
GII89_05465	COG0561	phosphatase activity
GII89_05470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GII89_05475	COG0475	glutathione-regulated potassium exporter activity
GII89_05480	COG0490	domain, Protein
GII89_05490	COG1024	Enoyl-CoA hydratase
GII89_05500	COG4152	abc transporter atp-binding protein
GII89_05505	COG1668	transmembrane transport
GII89_05510	COG0420	3'-5' exonuclease activity
GII89_05515	COG4717	serine-type aminopeptidase activity
GII89_05520	COG3481	metal-dependent phosphohydrolase, HD sub domain
GII89_05530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GII89_05560	COG1846	Transcriptional regulator
GII89_05565	COG4980	gas vesicle protein
GII89_05580	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GII89_05585	COG0537	adenosine 5'-monophosphoramidase activity
GII89_05590	COG1131	(ABC) transporter
GII89_05595	COG4473	ABC transporter
GII89_05605	COG1473	amidohydrolase
GII89_05610	COG3069	C4-dicarboxylate transmembrane transporter activity
GII89_05620	COG2329	Antibiotic biosynthesis monooxygenase
GII89_05625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GII89_05630	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GII89_05645	COG1309	transcriptional regulator
GII89_05650	COG1511	domain protein
GII89_05655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GII89_05660	COG4377	Putative membrane peptidase family (DUF2324)
GII89_05670	COG1363	Peptidase, m42
GII89_05675	COG4405	Protein conserved in bacteria
GII89_05680	COG1301	dicarboxylic acid transport
GII89_05690	COG1234	tRNA 3'-trailer cleavage
GII89_05695	COG0095	Lipoate-protein ligase
GII89_05700	COG0702	epimerase
GII89_05705	COG0318	PFAM AMP-dependent synthetase and ligase
GII89_05715	COG0501	Belongs to the peptidase M48B family
GII89_05720	COG1404	Belongs to the peptidase S8 family
GII89_05725	COG0456	acetyltransferase
GII89_05730	COG0604	alcohol dehydrogenase
GII89_05735	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GII89_05740	COG0406	alpha-ribazole phosphatase activity
GII89_05745	COG0183	Belongs to the thiolase family
GII89_05750	COG0318	PFAM AMP-dependent synthetase and ligase
GII89_05755	COG1268	BioY protein
GII89_05760	COG0840	transmembrane signaling receptor activity
GII89_05765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GII89_05765	COG0723	plastoquinol--plastocyanin reductase activity
GII89_05770	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_05780	COG4903	ComK protein
GII89_05785	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_05795	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GII89_05810	COG0398	Pfam SNARE associated Golgi protein
GII89_05815	COG0681	Belongs to the peptidase S26 family
GII89_05820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GII89_05825	COG1846	Transcriptional regulator
GII89_05830	COG0738	Major facilitator superfamily
GII89_05835	COG0673	inositol 2-dehydrogenase activity
GII89_05840	COG0561	phosphatase activity
GII89_05845	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GII89_05850	COG1609	Transcriptional regulator
GII89_05855	COG3180	Ammonia monooxygenase
GII89_05860	COG0477	Major facilitator Superfamily
GII89_05860	COG2814	Major facilitator Superfamily
GII89_05865	COG4533	DNA binding
GII89_05875	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
GII89_05880	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GII89_05885	COG1074	ATP-dependent DNA helicase activity
GII89_05890	COG0420	3'-5' exonuclease activity
GII89_05895	COG0419	ATPase involved in DNA repair
GII89_05900	COG1403	HNH endonuclease
GII89_05940	COG5337	Spore coat protein CotH
GII89_05945	COG0179	Fumarylacetoacetate (FAA) hydrolase
GII89_05955	COG1404	Belongs to the peptidase S8 family
GII89_05965	COG0367	asparagine synthase
GII89_05970	COG2318	DinB family
GII89_05975	COG1562	ergosterol biosynthetic process
GII89_05980	COG0534	Mate efflux family protein
GII89_05985	COG2207	Transcriptional regulator
GII89_05985	COG1917	Cupin 2, conserved barrel domain protein
GII89_05990	COG1609	Transcriptional regulator
GII89_05995	COG0673	inositol 2-dehydrogenase activity
GII89_06000	COG2318	DinB family
GII89_06005	COG1279	arginine transmembrane transporter activity
GII89_06010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GII89_06015	COG1357	PFAM Pentapeptide repeats (8 copies)
GII89_06020	COG2267	carboxylic ester hydrolase activity
GII89_06025	COG0529	Catalyzes the synthesis of activated sulfate
GII89_06030	COG2046	Belongs to the sulfate adenylyltransferase family
GII89_06035	COG0175	sulfate reduction
GII89_06040	COG2045	Belongs to the ComB family
GII89_06045	COG1809	phosphosulfolactate synthase activity
GII89_06050	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GII89_06055	COG4948	Mandelate Racemase Muconate Lactonizing
GII89_06060	COG2814	Major facilitator Superfamily
GII89_06065	COG0454	-acetyltransferase
GII89_06070	COG2153	protein acetylation
GII89_06075	COG0646	methionine synthase
GII89_06075	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GII89_06080	COG1666	GTP binding
GII89_06085	COG2996	Protein conserved in bacteria
GII89_06105	COG1695	Transcriptional regulator
GII89_06120	COG3227	Zinc metalloprotease (Elastase)
GII89_06125	COG1307	EDD domain protein, DegV family
GII89_06130	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GII89_06145	COG0561	phosphatase activity
GII89_06150	COG1073	alpha beta
GII89_06155	COG2151	metal-sulfur cluster biosynthetic enzyme
GII89_06165	COG0277	FAD linked oxidase domain protein
GII89_06170	COG2271	Major facilitator Superfamily
GII89_06175	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GII89_06190	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GII89_06195	COG0505	Belongs to the CarA family
GII89_06200	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GII89_06205	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GII89_06220	COG2267	carboxylic ester hydrolase activity
GII89_06230	COG1744	ABC transporter substrate-binding protein PnrA-like
GII89_06245	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GII89_06250	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GII89_06255	COG5504	Zn-dependent protease
GII89_06260	COG0444	Belongs to the ABC transporter superfamily
GII89_06265	COG4608	Belongs to the ABC transporter superfamily
GII89_06275	COG0601	transmembrane transport
GII89_06280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GII89_06290	COG0180	Tryptophanyl-tRNA synthetase
GII89_06295	COG4166	transmembrane transport
GII89_06300	COG0601	transmembrane transport
GII89_06305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GII89_06310	COG0444	Belongs to the ABC transporter superfamily
GII89_06315	COG4608	Belongs to the ABC transporter superfamily
GII89_06320	COG2814	Major facilitator Superfamily
GII89_06325	COG0456	acetyltransferase
GII89_06330	COG1393	Belongs to the ArsC family
GII89_06335	COG0861	Integral membrane protein TerC family
GII89_06345	COG4862	establishment of competence for transformation
GII89_06355	COG4469	Competence protein
GII89_06360	COG1164	Oligoendopeptidase f
GII89_06375	COG2346	COG2346, Truncated hemoglobins
GII89_06380	COG0741	lytic transglycosylase activity
GII89_06385	COG4116	CYTH
GII89_06395	COG2357	RelA SpoT domain protein
GII89_06400	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GII89_06405	COG0564	pseudouridine synthase activity
GII89_06410	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GII89_06415	COG0475	glutathione-regulated potassium exporter activity
GII89_06415	COG0569	domain protein
GII89_06420	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GII89_06425	COG0352	thiamine-phosphate diphosphorylase activity
GII89_06430	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GII89_06435	COG2104	thiamine diphosphate biosynthetic process
GII89_06440	COG2022	thiamine diphosphate biosynthetic process
GII89_06445	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GII89_06450	COG0351	phosphomethylpyrimidine kinase
GII89_06455	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GII89_06510	COG0210	DNA helicase
GII89_06520	COG2153	protein acetylation
GII89_06525	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GII89_06530	COG2382	esterase
GII89_06535	COG0626	cystathionine gamma-synthase activity
GII89_06540	COG0626	cystathionine gamma-synthase activity
GII89_06545	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GII89_06550	COG5505	Protein of unknown function (DUF819)
GII89_06580	COG3677	Transposase
GII89_06595	COG5484	DNA packaging
GII89_06600	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GII89_06605	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_06615	COG3711	transcriptional antiterminator
GII89_06615	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII89_06620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GII89_06620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII89_06620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GII89_06625	COG1482	cell wall glycoprotein biosynthetic process
GII89_06635	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GII89_06645	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GII89_06660	COG0109	protoheme IX farnesyltransferase activity
GII89_06670	COG0726	polysaccharide deacetylase
GII89_06685	COG5504	Zn-dependent protease
GII89_06690	COG2205	protein histidine kinase activity
GII89_06700	COG3383	formate dehydrogenase (NAD+) activity
GII89_06705	COG2427	Protein of unknown function (DUF1641)
GII89_06715	COG1051	belongs to the nudix hydrolase family
GII89_06725	COG2124	cytochrome p450
GII89_06730	COG1819	glycosyl
GII89_06740	COG1587	Uroporphyrinogen-III synthase
GII89_06745	COG0390	transport system, permease component
GII89_06750	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GII89_06755	COG0697	spore germination
GII89_06760	COG4297	protein containing double-stranded beta helix domain
GII89_06770	COG1252	NADH dehydrogenase
GII89_06775	COG1904	glucuronate isomerase
GII89_06780	COG2211	Major facilitator Superfamily
GII89_06785	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GII89_06790	COG1063	alcohol dehydrogenase
GII89_06795	COG1312	Catalyzes the dehydration of D-mannonate
GII89_06800	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_06805	COG2271	Major facilitator Superfamily
GII89_06810	COG1609	Transcriptional regulator
GII89_06815	COG0246	Mannitol dehydrogenase
GII89_06820	COG2721	sulfolactate sulfo-lyase activity
GII89_06825	COG0730	response to heat
GII89_06830	COG2318	DinB family
GII89_06835	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GII89_06840	COG0457	Tetratricopeptide repeat
GII89_06850	COG2350	Protein conserved in bacteria
GII89_06855	COG5632	N-Acetylmuramoyl-L-alanine amidase
GII89_06855	COG3409	Peptidoglycan-binding domain 1 protein
GII89_06855	COG1388	LysM domain
GII89_06865	COG4195	phage-related replication protein
GII89_06870	COG3546	catalase activity
GII89_06875	COG2856	Zn peptidase
GII89_06880	COG1396	sequence-specific DNA binding
GII89_06890	COG1522	sequence-specific DNA binding
GII89_06895	COG1484	DNA-dependent DNA replication
GII89_06915	COG1595	DNA-templated transcription, initiation
GII89_06920	COG5484	DNA packaging
GII89_06920	COG3728	DNA packaging
GII89_06925	COG1783	phage Terminase large subunit
GII89_06930	COG5518	Phage portal protein
GII89_06935	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GII89_06940	COG4653	Phage capsid family
GII89_06990	COG3953	SLT domain
GII89_06990	COG5412	phage tail tape measure protein
GII89_06995	COG1652	LysM domain
GII89_07000	COG4193	domain, Protein
GII89_07010	COG3628	GPW Gp25 family protein
GII89_07015	COG3299	homolog of phage Mu protein gp47
GII89_07020	COG3778	Protein conserved in bacteria
GII89_07060	COG3409	Peptidoglycan-binding domain 1 protein
GII89_07060	COG5632	N-Acetylmuramoyl-L-alanine amidase
GII89_07080	COG0306	phosphate transporter
GII89_07085	COG1392	Phosphate transport regulator
GII89_07090	COG0531	amino acid
GII89_07095	COG0346	lactoylglutathione lyase activity
GII89_07105	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GII89_07110	COG0463	Glycosyl transferase, family 2
GII89_07115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GII89_07120	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GII89_07125	COG2362	D-Aminopeptidase
GII89_07130	COG0601	transmembrane transport
GII89_07135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GII89_07140	COG0444	Belongs to the ABC transporter superfamily
GII89_07145	COG4166	transmembrane transport
GII89_07150	COG1619	proteins homologs of microcin C7 resistance protein MccF
GII89_07155	COG4948	Mandelate Racemase Muconate Lactonizing
GII89_07160	COG0791	NLP P60 protein
GII89_07165	COG4608	Belongs to the ABC transporter superfamily
GII89_07170	COG2706	6-phosphogluconolactonase activity
GII89_07175	COG1834	amidinotransferase
GII89_07180	COG1607	acyl-coa hydrolase
GII89_07185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GII89_07185	COG1017	nitric oxide dioxygenase activity
GII89_07195	COG2323	membrane
GII89_07200	COG2318	DinB family
GII89_07205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GII89_07210	COG2076	Multidrug Resistance protein
GII89_07215	COG2076	Multidrug Resistance protein
GII89_07220	COG0788	formyltetrahydrofolate deformylase activity
GII89_07225	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GII89_07230	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GII89_07235	COG1764	response to oxidative stress
GII89_07240	COG1846	Transcriptional regulator
GII89_07245	COG1764	response to oxidative stress
GII89_07255	COG0590	tRNA wobble adenosine to inosine editing
GII89_07260	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GII89_07265	COG1404	Belongs to the peptidase S8 family
GII89_07270	COG1366	Belongs to the anti-sigma-factor antagonist family
GII89_07275	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GII89_07280	COG1122	ATPase activity
GII89_07285	COG4721	ABC-type cobalt transport system, permease component
GII89_07295	COG0745	RESPONSE REGULATOR receiver
GII89_07300	COG3850	Histidine kinase
GII89_07300	COG5002	protein histidine kinase activity
GII89_07305	COG3212	peptidase
GII89_07310	COG3212	peptidase
GII89_07320	COG2239	Acts as a magnesium transporter
GII89_07325	COG0789	Transcriptional regulator
GII89_07340	COG1846	Transcriptional regulator
GII89_07345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GII89_07350	COG0726	polysaccharide deacetylase
GII89_07355	COG1408	metallophosphoesterase
GII89_07365	COG0463	Glycosyl transferase, family 2
GII89_07370	COG3285	dna ligase
GII89_07370	COG1793	dna ligase
GII89_07375	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GII89_07380	COG3300	MHYT domain
GII89_07380	COG5001	Diguanylate cyclase
GII89_07385	COG0586	Pfam SNARE associated Golgi protein
GII89_07390	COG0861	Integral membrane protein TerC family
GII89_07395	COG1191	sigma factor activity
GII89_07415	COG0501	Belongs to the peptidase M48B family
GII89_07420	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GII89_07435	COG3594	Acyltransferase
GII89_07440	COG5002	protein histidine kinase activity
GII89_07445	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GII89_07455	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GII89_07460	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
GII89_07465	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GII89_07470	COG0436	Aminotransferase
GII89_07475	COG1850	ribulose-bisphosphate carboxylase activity
GII89_07480	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
GII89_07485	COG0235	Class ii aldolase
GII89_07490	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GII89_07495	COG3339	Conserved Protein
GII89_07510	COG3852	Histidine kinase
GII89_07515	COG1846	Transcriptional regulator
GII89_07520	COG1360	Flagellar Motor Protein
GII89_07525	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GII89_07530	COG0542	response to heat
GII89_07535	COG3949	Membrane
GII89_07540	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GII89_07545	COG0720	synthase
GII89_07550	COG0602	queuosine metabolic process
GII89_07555	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GII89_07560	COG1733	regulation of RNA biosynthetic process
GII89_07565	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_07570	COG4641	Protein conserved in bacteria
GII89_07570	COG1388	LysM domain
GII89_07575	COG1388	LysM domain
GII89_07590	COG4873	Protein conserved in bacteria
GII89_07600	COG3773	Cell wall hydrolase
GII89_07605	COG2244	polysaccharide biosynthetic process
GII89_07610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII89_07615	COG2217	Heavy metal translocating P-type atpase
GII89_07625	COG0006	proline dipeptidase activity
GII89_07630	COG1609	Transcriptional regulator
GII89_07635	COG3711	transcriptional antiterminator
GII89_07640	COG1263	PTS System
GII89_07640	COG2190	(PTS) system
GII89_07640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII89_07645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII89_07650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GII89_07660	COG1533	DNA photolyase activity
GII89_07665	COG0456	acetyltransferase
GII89_07670	COG0840	transmembrane signaling receptor activity
GII89_07675	COG2084	Dehydrogenase
GII89_07680	COG2340	Cysteine-rich secretory protein family
GII89_07685	COG0768	penicillin binding
GII89_07690	COG4191	Histidine kinase
GII89_07695	COG0436	Aminotransferase
GII89_07705	COG0784	Response regulator, receiver
GII89_07705	COG0835	chemotaxis
GII89_07715	COG2814	Major facilitator Superfamily
GII89_07720	COG1376	ErfK ybiS ycfS ynhG family protein
GII89_07725	COG1408	metallophosphoesterase
GII89_07730	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_07735	COG3409	Peptidoglycan-binding domain 1 protein
GII89_07740	COG3409	Peptidoglycan-binding domain 1 protein
GII89_07750	COG2200	EAL domain
GII89_07755	COG4703	Protein of unknown function (DUF1797)
GII89_07760	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
GII89_07770	COG0517	IMP dehydrogenase activity
GII89_07775	COG0583	DNA-binding transcription factor activity
GII89_07780	COG0716	FMN binding
GII89_07790	COG0716	FMN binding
GII89_07795	COG2171	N-acyltransferase activity
GII89_07800	COG1473	amidohydrolase
GII89_07810	COG0668	transmembrane transport
GII89_07815	COG0450	alkyl hydroperoxide reductase
GII89_07820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII89_07835	COG0746	molybdenum cofactor guanylyltransferase activity
GII89_07840	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GII89_07845	COG0303	'Molybdopterin
GII89_07850	COG1763	Mo-molybdopterin cofactor biosynthetic process
GII89_07855	COG0314	molybdopterin synthase activity
GII89_07860	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GII89_07865	COG1132	(ABC) transporter
GII89_07870	COG1132	(ABC) transporter
GII89_07880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GII89_07885	COG1136	(ABC) transporter
GII89_07890	COG0577	efflux transmembrane transporter activity
GII89_07895	COG1349	DNA-binding transcription factor activity
GII89_07900	COG1105	Belongs to the carbohydrate kinase PfkB family
GII89_07905	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GII89_07905	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GII89_07905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII89_07910	COG0681	Belongs to the peptidase S26 family
GII89_07920	COG0488	(ABC) transporter
GII89_07925	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GII89_07930	COG2309	aminopeptidase activity
GII89_07940	COG1077	Cell shape determining protein MreB Mrl
GII89_07945	COG2002	toxin-antitoxin pair type II binding
GII89_07950	COG3852	Histidine kinase
GII89_07955	COG2105	PFAM AIG2 family protein
GII89_07955	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
GII89_07960	COG0569	domain protein
GII89_07965	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GII89_07970	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GII89_07980	COG0561	phosphatase activity
GII89_07985	COG0242	peptide deformylase activity
GII89_07995	COG0497	DNA recombination
GII89_08000	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GII89_08005	COG0022	dehydrogenase e1 component
GII89_08010	COG0508	dehydrogenase complex catalyzes the overall conversion of
GII89_08015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GII89_08020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII89_08030	COG1982	Orn Lys Arg decarboxylase major
GII89_08035	COG4476	Belongs to the UPF0223 family
GII89_08040	COG4493	Belongs to the UPF0637 family
GII89_08050	COG0483	inositol monophosphate 1-phosphatase activity
GII89_08060	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GII89_08080	COG1595	DNA-templated transcription, initiation
GII89_08110	COG4896	Protein conserved in bacteria
GII89_08120	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GII89_08125	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GII89_08130	COG2066	Belongs to the glutaminase family
GII89_08135	COG4838	Belongs to the UPF0358 family
GII89_08140	COG0772	Belongs to the SEDS family
GII89_08145	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GII89_08150	COG1612	heme a metabolic process
GII89_08155	COG0109	protoheme IX farnesyltransferase activity
GII89_08160	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GII89_08160	COG2010	Cytochrome c
GII89_08165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GII89_08170	COG1845	cytochrome c oxidase, subunit III
GII89_08175	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GII89_08180	COG3336	cytochrome c oxidase
GII89_08190	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GII89_08195	COG2340	Cysteine-rich secretory protein family
GII89_08210	COG3679	Belongs to the UPF0342 family
GII89_08215	COG4471	UPF0298 protein
GII89_08220	COG0742	ribosomal rna small subunit methyltransferase
GII89_08225	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GII89_08230	COG3314	Sporulation integral membrane protein YlbJ
GII89_08235	COG1752	Esterase of the alpha-beta hydrolase superfamily
GII89_08240	COG3480	Lon protease (S16) C-terminal proteolytic domain
GII89_08245	COG1323	Belongs to the UPF0348 family
GII89_08255	COG1399	metal-binding, possibly nucleic acid-binding protein
GII89_08260	COG0333	Belongs to the bacterial ribosomal protein bL32 family
GII89_08270	COG0454	-acetyltransferase
GII89_08275	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GII89_08280	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GII89_08285	COG2001	Belongs to the MraZ family
GII89_08290	COG0275	rRNA processing
GII89_08295	COG4839	cell division protein FtsL
GII89_08305	COG0768	penicillin binding
GII89_08310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GII89_08315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GII89_08320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GII89_08325	COG0772	Belongs to the SEDS family
GII89_08330	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GII89_08335	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GII89_08340	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GII89_08345	COG3879	Bacterial protein of unknown function (DUF881)
GII89_08350	COG3879	Bacterial protein of unknown function (DUF881)
GII89_08355	COG3856	small basic protein
GII89_08360	COG0849	cell division
GII89_08365	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GII89_08370	COG4412	M6 family metalloprotease domain protein
GII89_08370	COG1404	Belongs to the peptidase S8 family
GII89_08380	COG1191	sigma factor activity
GII89_08385	COG1191	sigma factor activity
GII89_08390	COG1119	ATPase activity
GII89_08395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GII89_08400	COG1873	PFAM PRC-barrel domain
GII89_08410	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GII89_08415	COG1799	cell septum assembly
GII89_08420	COG0762	integral membrane protein
GII89_08425	COG2302	S4 RNA-binding domain
GII89_08430	COG3599	regulation of cell shape
GII89_08435	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GII89_08440	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GII89_08445	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GII89_08450	COG0564	pseudouridine synthase activity
GII89_08455	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GII89_08460	COG2233	PERMEase
GII89_08465	COG0540	Belongs to the ATCase OTCase family
GII89_08470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GII89_08475	COG0505	Belongs to the CarA family
GII89_08480	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GII89_08485	COG0543	2 iron, 2 sulfur cluster binding
GII89_08490	COG0167	dihydroorotate dehydrogenase activity
GII89_08495	COG0284	orotidine-5'-phosphate decarboxylase activity
GII89_08500	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GII89_08505	COG0175	sulfate reduction
GII89_08510	COG0306	phosphate transporter
GII89_08515	COG2046	Belongs to the sulfate adenylyltransferase family
GII89_08520	COG0529	Catalyzes the synthesis of activated sulfate
GII89_08525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GII89_08530	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
GII89_08535	COG1648	precorrin-2 dehydrogenase activity
GII89_08545	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GII89_08550	COG1561	YicC-like family, N-terminal region
GII89_08555	COG2052	Domain of unknown function (DUF370)
GII89_08560	COG0194	GDP metabolic process
GII89_08565	COG1758	RNA polymerase activity
GII89_08570	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GII89_08575	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GII89_08580	COG0242	peptide deformylase activity
GII89_08585	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GII89_08590	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GII89_08590	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GII89_08595	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GII89_08600	COG0631	protein serine/threonine phosphatase activity
GII89_08605	COG0515	serine threonine protein kinase
GII89_08605	COG2815	serine threonine protein kinase
GII89_08610	COG1162	GTPase activity
GII89_08615	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GII89_08620	COG1564	THIamine pyrophosphokinase
GII89_08630	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GII89_08635	COG1302	Protein conserved in bacteria
GII89_08640	COG1461	Dihydroxyacetone kinase
GII89_08645	COG1760	l-serine dehydratase
GII89_08650	COG1760	l-serine dehydratase
GII89_08655	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GII89_08660	COG1349	DNA-binding transcription factor activity
GII89_08660	COG2050	protein possibly involved in aromatic compounds catabolism
GII89_08665	COG0416	fatty acid biosynthetic process
GII89_08670	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GII89_08675	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_08680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GII89_08685	COG0571	ribonuclease III activity
GII89_08690	COG1196	nuclear chromosome segregation
GII89_08695	COG0552	protein localization to endoplasmic reticulum
GII89_08705	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GII89_08710	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GII89_08715	COG0228	four-way junction DNA binding
GII89_08720	COG1837	Belongs to the UPF0109 family
GII89_08730	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GII89_08735	COG0336	Belongs to the RNA methyltransferase TrmD family
GII89_08740	COG0335	large ribosomal subunit rRNA binding
GII89_08745	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GII89_08750	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GII89_08760	COG2257	FlhB HrpN YscU SpaS Family
GII89_08765	COG0045	succinate-CoA ligase (ADP-forming) activity
GII89_08770	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GII89_08775	COG0758	DNA mediated transformation
GII89_08780	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GII89_08785	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GII89_08790	COG4974	Belongs to the 'phage' integrase family
GII89_08795	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GII89_08800	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GII89_08805	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GII89_08810	COG1815	bacterial-type flagellum-dependent cell motility
GII89_08815	COG1558	bacterial-type flagellum-dependent cell motility
GII89_08820	COG1677	Flagellar hook-basal body complex protein FliE
GII89_08825	COG1766	The M ring may be actively involved in energy transduction
GII89_08830	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GII89_08835	COG1317	bacterial-type flagellum organization
GII89_08840	COG1157	protein secretion by the type III secretion system
GII89_08845	COG2882	bacterial-type flagellum organization
GII89_08850	COG3334	PFAM MgtE intracellular
GII89_08855	COG3144	bacterial-type flagellum assembly
GII89_08860	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GII89_08865	COG4786	Flagellar basal body rod
GII89_08870	COG1582	Flagellar protein (FlbD)
GII89_08875	COG1580	Controls the rotational direction of flagella during chemotaxis
GII89_08880	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GII89_08885	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GII89_08885	COG1776	CheC inhibitor of MCP methylation
GII89_08890	COG2201	protein-glutamate methylesterase activity
GII89_08895	COG3190	flagellar
GII89_08900	COG1338	Plays a role in the flagellum-specific transport system
GII89_08905	COG1987	bacterial-type flagellum assembly
GII89_08910	COG1684	flagellar biosynthetic protein fliR
GII89_08915	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GII89_08920	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GII89_08925	COG1419	protein localization to endoplasmic reticulum
GII89_08930	COG0455	bacterial-type flagellum organization
GII89_08935	COG2201	protein-glutamate methylesterase activity
GII89_08940	COG0643	Histidine kinase
GII89_08940	COG2198	Histidine kinase
GII89_08945	COG0835	chemotaxis
GII89_08950	COG1776	CheC inhibitor of MCP methylation
GII89_08955	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GII89_08960	COG1191	sigma factor activity
GII89_08970	COG0052	Belongs to the universal ribosomal protein uS2 family
GII89_08975	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GII89_08980	COG0528	UMP kinase activity
GII89_08985	COG0233	cytoplasmic translational termination
GII89_08990	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GII89_08995	COG4589	Belongs to the CDS family
GII89_09000	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GII89_09005	COG0750	zinc metalloprotease
GII89_09010	COG0442	prolyl-tRNA aminoacylation
GII89_09015	COG2176	DNA-directed DNA polymerase activity
GII89_09020	COG0779	Required for maturation of 30S ribosomal subunits
GII89_09025	COG0195	Participates in both transcription termination and antitermination
GII89_09030	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GII89_09035	COG1358	cellular component organization or biogenesis
GII89_09040	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GII89_09045	COG1550	Protein conserved in bacteria
GII89_09050	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GII89_09055	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GII89_09060	COG0196	riboflavin kinase activity
GII89_09065	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GII89_09070	COG1185	polyribonucleotide nucleotidyltransferase activity
GII89_09075	COG0726	polysaccharide deacetylase
GII89_09080	COG0612	Peptidase, M16
GII89_09085	COG1873	PFAM PRC-barrel domain
GII89_09090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GII89_09095	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GII89_09100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GII89_09105	COG0527	aspartate kinase activity
GII89_09110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GII89_09115	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GII89_09120	COG0740	serine-type endopeptidase activity
GII89_09130	COG1674	ftsk spoiiie
GII89_09130	COG4980	gas vesicle protein
GII89_09135	COG2188	Transcriptional regulator
GII89_09140	COG2814	Major facilitator Superfamily
GII89_09145	COG0612	Peptidase, M16
GII89_09150	COG0612	Peptidase, M16
GII89_09155	COG0300	oxidoreductase activity
GII89_09170	COG1426	Protein conserved in bacteria
GII89_09175	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GII89_09180	COG1058	Belongs to the CinA family
GII89_09180	COG1546	Belongs to the CinA family
GII89_09185	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GII89_09190	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GII89_09195	COG1418	mRNA catabolic process
GII89_09200	COG1692	metallophosphoesterase
GII89_09205	COG2359	stage V sporulation protein S
GII89_09210	COG1063	alcohol dehydrogenase
GII89_09215	COG0156	8-amino-7-oxononanoate synthase activity
GII89_09220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GII89_09225	COG4550	Control of competence regulator ComK, YlbF/YmcA
GII89_09235	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GII89_09240	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GII89_09255	COG3226	Transcriptional regulator
GII89_09260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GII89_09270	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GII89_09275	COG3321	synthase
GII89_09280	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GII89_09280	COG2070	2-Nitropropane dioxygenase
GII89_09285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GII89_09290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GII89_09295	COG3425	synthase
GII89_09300	COG1024	Enoyl-CoA hydratase
GII89_09305	COG1024	Enoyl-CoA hydratase
GII89_09310	COG0300	oxidoreductase activity
GII89_09310	COG0318	PFAM AMP-dependent synthetase and ligase
GII89_09310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII89_09310	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_09310	COG3321	synthase
GII89_09315	COG3321	synthase
GII89_09315	COG0300	oxidoreductase activity
GII89_09315	COG4221	oxidoreductase activity
GII89_09315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GII89_09320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GII89_09320	COG3321	synthase
GII89_09320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GII89_09320	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_09320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII89_09325	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_09325	COG3321	synthase
GII89_09325	COG4221	oxidoreductase activity
GII89_09325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII89_09330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GII89_09330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GII89_09330	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GII89_09330	COG3321	synthase
GII89_09335	COG2124	cytochrome p450
GII89_09345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GII89_09350	COG1404	Belongs to the peptidase S8 family
GII89_09355	COG4195	phage-related replication protein
GII89_09360	COG1764	response to oxidative stress
GII89_09365	COG2076	Multidrug Resistance protein
GII89_09370	COG2076	Multidrug Resistance protein
GII89_09385	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GII89_09390	COG1923	regulation of RNA biosynthetic process
GII89_09405	COG1780	Probably involved in ribonucleotide reductase function
GII89_09410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GII89_09415	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GII89_09420	COG4112	unkown
GII89_09425	COG0860	N-Acetylmuramoyl-L-alanine amidase
GII89_09430	COG0464	growth
GII89_09435	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GII89_09440	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GII89_09445	COG0789	Transcriptional regulator
GII89_09450	COG0174	glutamine synthetase
GII89_09470	COG4282	regulation of fungal-type cell wall biogenesis
GII89_09480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GII89_09510	COG0135	phosphoribosylanthranilate isomerase activity
GII89_09515	COG2211	Major facilitator Superfamily
GII89_09520	COG3507	Belongs to the glycosyl hydrolase 43 family
GII89_09525	COG1940	carbohydrate kinase activity
GII89_09530	COG2115	Belongs to the xylose isomerase family
GII89_09535	COG1070	Carbohydrate kinase
GII89_09545	COG1525	nuclease
GII89_09550	COG2814	Major facilitator Superfamily
GII89_09555	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GII89_09565	COG0756	dUTP diphosphatase activity
GII89_09580	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GII89_09605	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GII89_09620	COG3832	glyoxalase III activity
GII89_09630	COG0697	spore germination
GII89_09635	COG0531	amino acid
GII89_09665	COG4195	phage-related replication protein
GII89_09675	COG0346	lactoylglutathione lyase activity
GII89_09680	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GII89_09685	COG1388	LysM domain
GII89_09690	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GII89_09695	COG4224	UPF0291 protein
GII89_09700	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GII89_09710	COG3763	UPF0154 protein
GII89_09720	COG0785	Cytochrome C biogenesis protein
GII89_09725	COG2201	protein-glutamate methylesterase activity
GII89_09730	COG4846	Membrane protein involved in cytochrome C biogenesis
GII89_09740	COG0071	Belongs to the small heat shock protein (HSP20) family
GII89_09755	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GII89_09760	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII89_09780	COG0824	Thioesterase
GII89_09790	COG4841	protein insertion into membrane
GII89_09795	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GII89_09800	COG1832	CoA-binding protein
GII89_09805	COG0187	DNA topoisomerase II activity
GII89_09810	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GII89_09820	COG1115	amino acid carrier protein
GII89_09825	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GII89_09835	COG5520	Belongs to the glycosyl hydrolase 30 family
GII89_09840	COG3507	Belongs to the glycosyl hydrolase 43 family
GII89_09845	COG2246	polysaccharide biosynthetic process
GII89_09850	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GII89_09855	COG0586	Pfam SNARE associated Golgi protein
GII89_09860	COG2404	hydrolase activity, acting on ester bonds
GII89_09865	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GII89_09870	COG1024	Enoyl-CoA hydratase
GII89_09875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GII89_09880	COG0511	ligase activity, forming carbon-carbon bonds
GII89_09885	COG0439	Biotin carboxylase
GII89_09890	COG0318	PFAM AMP-dependent synthetase and ligase
GII89_09895	COG1960	acyl-CoA dehydrogenase activity
GII89_09910	COG1649	PFAM Uncharacterised BCR, COG1649
GII89_09920	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GII89_09920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII89_09925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII89_09930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII89_09935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII89_09940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII89_09945	COG2027	D-alanyl-D-alanine carboxypeptidase
GII89_09950	COG2017	converts alpha-aldose to the beta-anomer
GII89_09955	COG0534	Mate efflux family protein
GII89_09970	COG0582	viral genome integration into host DNA
GII89_09975	COG0166	Belongs to the GPI family
GII89_09980	COG0405	Gamma-glutamyltransferase
GII89_09985	COG0583	DNA-binding transcription factor activity
GII89_09990	COG0604	alcohol dehydrogenase
GII89_09995	COG0493	'glutamate synthase
GII89_10000	COG0069	glutamate synthase activity
GII89_10000	COG0067	glutamate synthase
GII89_10000	COG0070	glutamate synthase
GII89_10005	COG0583	DNA-binding transcription factor activity
GII89_10010	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GII89_10015	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GII89_10025	COG0300	oxidoreductase activity
GII89_10030	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GII89_10040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GII89_10045	COG2814	Major facilitator Superfamily
GII89_10050	COG1070	Carbohydrate kinase
GII89_10055	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GII89_10060	COG0243	molybdopterin cofactor binding
GII89_10090	COG0840	transmembrane signaling receptor activity
GII89_10090	COG5278	phosphoserine phosphatase activity
GII89_10095	COG2368	4-hydroxyphenylacetate
GII89_10100	COG4305	rare lipoprotein A
GII89_10105	COG3619	membrane
GII89_10110	COG3866	Pectate lyase
GII89_10115	COG2135	peptidase activity
GII89_10125	COG2140	Oxalate decarboxylase
GII89_10140	COG0456	acetyltransferase
GII89_10160	COG2720	vancomycin resistance protein
GII89_10170	COG3655	Transcriptional regulator
GII89_10175	COG3739	integral membrane protein
GII89_10180	COG0583	DNA-binding transcription factor activity
GII89_10185	COG0697	spore germination
GII89_10195	COG0693	protein deglycase activity
GII89_10200	COG2367	Beta-lactamase
GII89_10225	COG3848	Pyruvate phosphate dikinase
GII89_10225	COG0574	Belongs to the PEP-utilizing enzyme family
GII89_10230	COG0726	polysaccharide deacetylase
GII89_10235	COG2314	TM2 domain
GII89_10240	COG1396	sequence-specific DNA binding
GII89_10255	COG2135	peptidase activity
GII89_10290	COG0457	Tetratricopeptide repeat
GII89_10315	COG5290	Psort location Cytoplasmic, score
GII89_10340	COG5444	nuclease activity
GII89_10345	COG4282	regulation of fungal-type cell wall biogenesis
GII89_10350	COG1231	oxidoreductase activity
GII89_10355	COG5434	Belongs to the glycosyl hydrolase 28 family
GII89_10360	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GII89_10365	COG0662	Cupin 2, conserved barrel domain protein
GII89_10365	COG2207	Transcriptional regulator
GII89_10370	COG0456	acetyltransferase
GII89_10375	COG1309	transcriptional regulator
GII89_10380	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GII89_10385	COG3708	Transcriptional regulator
GII89_10390	COG2378	regulation of single-species biofilm formation
GII89_10400	COG0640	Transcriptional regulator
GII89_10405	COG0741	lytic transglycosylase activity
GII89_10410	COG2322	membrane
GII89_10425	COG1619	proteins homologs of microcin C7 resistance protein MccF
GII89_10430	COG3239	Fatty acid desaturase
GII89_10435	COG4585	Histidine kinase
GII89_10440	COG2197	response regulator
GII89_10445	COG3584	3D domain protein
GII89_10445	COG1388	LysM domain
GII89_10450	COG0514	ATP-dependent DNA helicase (RecQ)
GII89_10460	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GII89_10465	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GII89_10480	COG0071	Belongs to the small heat shock protein (HSP20) family
GII89_10505	COG1012	belongs to the aldehyde dehydrogenase family
GII89_10510	COG1657	PFAM Prenyltransferase squalene oxidase
GII89_10515	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GII89_10520	COG0733	neurotransmitter:sodium symporter activity
GII89_10525	COG0385	Bile acid
GII89_10530	COG0508	dehydrogenase complex catalyzes the overall conversion of
GII89_10535	COG0567	Dehydrogenase, E1 component
GII89_10540	COG4548	von Willebrand factor, type A
GII89_10545	COG0714	Associated with various cellular activities
GII89_10550	COG2032	superoxide dismutase activity
GII89_10555	COG0791	NLP P60 protein
GII89_10555	COG1388	LysM domain
GII89_10560	COG1819	glycosyl
GII89_10565	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GII89_10570	COG0534	Mate efflux family protein
GII89_10575	COG1366	Belongs to the anti-sigma-factor antagonist family
GII89_10580	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GII89_10585	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GII89_10595	COG2962	Rard protein
GII89_10610	COG2610	gluconate transmembrane transporter activity
GII89_10615	COG1942	4-Oxalocrotonate Tautomerase
GII89_10620	COG1733	regulation of RNA biosynthetic process
GII89_10625	COG0778	Nitroreductase
GII89_10630	COG0400	carboxylic ester hydrolase activity
GII89_10635	COG0346	lactoylglutathione lyase activity
GII89_10645	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GII89_10650	COG3409	Peptidoglycan-binding domain 1 protein
GII89_10650	COG0793	Belongs to the peptidase S41A family
GII89_10655	COG2226	methyltransferase
GII89_10665	COG1876	peptidase activity
GII89_10670	COG0813	purine-nucleoside phosphorylase activity
GII89_10685	COG0671	phosphoesterase, PA-phosphatase related
GII89_10705	COG4479	Belongs to the UPF0346 family
GII89_10715	COG1509	lysine 2,3-aminomutase activity
GII89_10720	COG0456	acetyltransferase
GII89_10725	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GII89_10730	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GII89_10735	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GII89_10740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GII89_10755	COG0456	acetyltransferase
GII89_10760	COG0463	Glycosyl transferase, family 2
GII89_10775	COG4641	Protein conserved in bacteria
GII89_10780	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
GII89_10785	COG1086	Polysaccharide biosynthesis protein
GII89_10795	COG3331	DNA recombination
GII89_10850	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GII89_10885	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
GII89_10890	COG0756	dUTP diphosphatase activity
GII89_10895	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII89_10915	COG1372	Participates in initiation and elongation during chromosome replication
GII89_10915	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GII89_10920	COG1372	Participates in initiation and elongation during chromosome replication
GII89_10920	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GII89_10925	COG1780	Probably involved in ribonucleotide reductase function
GII89_11015	COG0270	DNA (cytosine-5-)-methyltransferase activity
GII89_11025	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
GII89_11030	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GII89_11055	COG3584	3D domain protein
GII89_11060	COG0587	DNA-directed DNA polymerase activity
GII89_11065	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GII89_11070	COG0358	DNA primase activity
GII89_11075	COG0305	Participates in initiation and elongation during chromosome replication
GII89_11085	COG2887	Belongs to the helicase family. UvrD subfamily
GII89_11115	COG3420	alginic acid biosynthetic process
GII89_11115	COG5434	Belongs to the glycosyl hydrolase 28 family
GII89_11120	COG4195	phage-related replication protein
GII89_11135	COG2135	peptidase activity
GII89_11140	COG1793	dna ligase
GII89_11195	COG4474	Belongs to the UPF0398 family
GII89_11205	COG1388	LysM domain
GII89_11225	COG3646	Phage regulatory protein
GII89_11225	COG3645	SOS response
GII89_11280	COG3655	Transcriptional regulator
GII89_11295	COG0582	viral genome integration into host DNA
GII89_11375	COG3655	Transcriptional regulator
GII89_11415	COG1395	domain, Protein
GII89_11430	COG0776	regulation of translation
GII89_11465	COG4373	Mu-like prophage FluMu protein gp28
GII89_11565	COG0582	viral genome integration into host DNA
GII89_11595	COG0739	heme binding
GII89_11595	COG0741	lytic transglycosylase activity
GII89_11595	COG1196	nuclear chromosome segregation
GII89_11605	COG2433	Pfam Transposase IS66
GII89_11615	COG5434	Belongs to the glycosyl hydrolase 28 family
GII89_11615	COG4632	Exopolysaccharide biosynthesis protein
GII89_11630	COG5632	N-Acetylmuramoyl-L-alanine amidase
GII89_11645	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GII89_11650	COG0463	Glycosyl transferase, family 2
GII89_11655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII89_11660	COG3271	cysteine-type peptidase activity
GII89_11660	COG2274	protein secretion by the type I secretion system
GII89_11675	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GII89_11705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GII89_11720	COG5444	nuclease activity
GII89_11725	COG4282	regulation of fungal-type cell wall biogenesis
GII89_11740	COG1525	nuclease
GII89_11750	COG2746	aminoglycoside 3-N-acetyltransferase activity
GII89_11775	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GII89_11780	COG1086	Polysaccharide biosynthesis protein
GII89_11785	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GII89_11790	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GII89_11795	COG1846	Transcriptional regulator
GII89_11800	COG0534	Mate efflux family protein
GII89_11810	COG4698	Protein conserved in bacteria
GII89_11815	COG2755	lipolytic protein G-D-S-L family
GII89_11820	COG1999	signal sequence binding
GII89_11830	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GII89_11835	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GII89_11840	COG1272	protein, Hemolysin III
GII89_11845	COG0204	Acyl-transferase
GII89_11850	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GII89_11855	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GII89_11860	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GII89_11870	COG2521	methyltransferase
GII89_11870	COG2136	Putative SAM-dependent methyltransferase
GII89_11880	COG0129	dihydroxy-acid dehydratase activity
GII89_11885	COG1413	lyase activity
GII89_11890	COG1418	mRNA catabolic process
GII89_11895	COG0386	Belongs to the glutathione peroxidase family
GII89_11900	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GII89_11905	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GII89_11915	COG1278	Cold shock
GII89_11935	COG0328	RNA-DNA hybrid ribonuclease activity
GII89_11940	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GII89_11945	COG0328	RNA-DNA hybrid ribonuclease activity
GII89_11955	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GII89_11970	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GII89_11980	COG1755	Isoprenylcysteine carboxyl methyltransferase
GII89_11985	COG3424	synthase
GII89_11990	COG2233	PERMEase
GII89_11995	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GII89_12000	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GII89_12010	COG0800	Aldolase
GII89_12015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GII89_12020	COG1609	Transcriptional regulator
GII89_12025	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GII89_12030	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_12035	COG1199	ATP-dependent helicase activity
GII89_12050	COG0116	Belongs to the methyltransferase superfamily
GII89_12065	COG4474	Belongs to the UPF0398 family
GII89_12080	COG3359	exonuclease
GII89_12085	COG1111	helicase
GII89_12085	COG1205	dead DEAH box helicase
GII89_12090	COG2190	(PTS) system
GII89_12095	COG0071	Belongs to the small heat shock protein (HSP20) family
GII89_12130	COG3331	DNA recombination
GII89_12135	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GII89_12135	COG4499	WXG100 protein secretion system (Wss), protein YukC
GII89_12145	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GII89_12150	COG3935	DnaD domain protein
GII89_12155	COG0017	Asparaginyl-tRNA synthetase
GII89_12160	COG0436	Aminotransferase
GII89_12165	COG5353	protein conserved in bacteria
GII89_12175	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GII89_12175	COG1199	ATP-dependent helicase activity
GII89_12180	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GII89_12185	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GII89_12190	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GII89_12195	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GII89_12195	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GII89_12200	COG0617	tRNA 3'-terminal CCA addition
GII89_12205	COG0438	transferase activity, transferring glycosyl groups
GII89_12210	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GII89_12215	COG1803	Methylglyoxal synthase
GII89_12220	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GII89_12225	COG1694	Mazg nucleotide pyrophosphohydrolase
GII89_12230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GII89_12240	COG4347	Protein of unknown function (DUF1405)
GII89_12245	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GII89_12245	COG2010	Cytochrome c
GII89_12250	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GII89_12255	COG0723	plastoquinol--plastocyanin reductase activity
GII89_12265	COG5582	Belongs to the UPF0302 family
GII89_12270	COG0457	Tetratricopeptide repeat
GII89_12275	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GII89_12280	COG0287	Prephenate dehydrogenase
GII89_12285	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GII89_12290	COG0159	tryptophan synthase activity
GII89_12295	COG0133	tryptophan synthase activity
GII89_12300	COG0135	phosphoribosylanthranilate isomerase activity
GII89_12310	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GII89_12315	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GII89_12320	COG4401	Chorismate mutase type I
GII89_12325	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GII89_12330	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GII89_12335	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GII89_12340	COG0105	UTP biosynthetic process
GII89_12345	COG0142	geranyltranstransferase activity
GII89_12350	COG2226	methyltransferase
GII89_12355	COG0142	geranyltranstransferase activity
GII89_12365	COG0302	gtp cyclohydrolase
GII89_12370	COG0776	regulation of translation
GII89_12375	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GII89_12390	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GII89_12395	COG1160	GTP binding
GII89_12420	COG1304	FMN binding
GII89_12425	COG0539	negative regulation of cytoplasmic translation
GII89_12430	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GII89_12440	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
GII89_12445	COG2959	enzyme of heme biosynthesis
GII89_12450	COG3773	Cell wall hydrolase
GII89_12450	COG3409	Peptidoglycan-binding domain 1 protein
GII89_12455	COG2339	peptidase activity
GII89_12460	COG0492	ferredoxin-NADP+ reductase activity
GII89_12465	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GII89_12470	COG4862	establishment of competence for transformation
GII89_12475	COG1408	metallophosphoesterase
GII89_12485	COG1388	LysM domain
GII89_12490	COG1266	CAAX protease self-immunity
GII89_12495	COG0514	ATP-dependent DNA helicase (RecQ)
GII89_12500	COG4955	Helix-turn-helix domain
GII89_12505	COG1141	Ferredoxin
GII89_12510	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GII89_12515	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GII89_12520	COG0710	3-dehydroquinate dehydratase activity
GII89_12530	COG1595	DNA-templated transcription, initiation
GII89_12535	COG5002	protein histidine kinase activity
GII89_12540	COG0745	RESPONSE REGULATOR receiver
GII89_12545	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GII89_12550	COG1333	cytochrome c biogenesis protein
GII89_12555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII89_12560	COG1187	pseudouridine synthase activity
GII89_12565	COG0700	Nucleoside recognition
GII89_12570	COG2715	membrane protein required for spore maturation
GII89_12575	COG1686	Belongs to the peptidase S11 family
GII89_12585	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GII89_12590	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GII89_12595	COG1547	Domain of unknown function (DUF309)
GII89_12600	COG0456	acetyltransferase
GII89_12605	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GII89_12610	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GII89_12610	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GII89_12615	COG0307	riboflavin synthase, alpha
GII89_12620	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GII89_12620	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GII89_12630	COG0681	Belongs to the peptidase S26 family
GII89_12640	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
GII89_12655	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GII89_12660	COG4086	secreted protein
GII89_12665	COG0019	diaminopimelate decarboxylase activity
GII89_12670	COG0697	spore germination
GII89_12685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GII89_12705	COG1191	sigma factor activity
GII89_12710	COG2172	sigma factor antagonist activity
GII89_12715	COG1366	Belongs to the anti-sigma-factor antagonist family
GII89_12720	COG1686	Belongs to the peptidase S11 family
GII89_12725	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GII89_12730	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GII89_12735	COG4974	Belongs to the 'phage' integrase family
GII89_12745	COG0735	belongs to the Fur family
GII89_12750	COG1300	Membrane
GII89_12760	COG0281	malic enzyme
GII89_12765	COG1757	Na H antiporter
GII89_12770	COG1027	Aspartate ammonia-lyase
GII89_12775	COG0252	asparaginase activity
GII89_12780	COG1396	sequence-specific DNA binding
GII89_12785	COG1379	DNA repair
GII89_12790	COG0494	nUDIX hydrolase
GII89_12800	COG0667	Aldo Keto reductase
GII89_12810	COG1073	alpha beta
GII89_12820	COG4918	Iron-sulphur cluster biosynthesis
GII89_12825	COG0456	acetyltransferase
GII89_12825	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GII89_12830	COG2329	Antibiotic biosynthesis monooxygenase
GII89_12835	COG0456	acetyltransferase
GII89_12845	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GII89_12855	COG2211	Major facilitator Superfamily
GII89_12860	COG0346	lactoylglutathione lyase activity
GII89_12865	COG1072	(Pantothenic acid kinase))
GII89_12870	COG3048	D-serine ammonia-lyase activity
GII89_12875	COG0300	oxidoreductase activity
GII89_12880	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GII89_12885	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GII89_12890	COG4187	Peptidase family M20/M25/M40
GII89_12895	COG1902	pentaerythritol trinitrate reductase activity
GII89_12900	COG0596	Alpha beta hydrolase
GII89_12910	COG1234	tRNA 3'-trailer cleavage
GII89_12915	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GII89_12920	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GII89_12925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GII89_12935	COG0706	membrane insertase activity
GII89_12940	COG3361	conserved protein (COG2071)
GII89_12945	COG2195	Cleaves the N-terminal amino acid of tripeptides
GII89_12950	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GII89_12955	COG0346	lactoylglutathione lyase activity
GII89_12965	COG1376	ErfK ybiS ycfS ynhG family protein
GII89_12970	COG4129	membrane
GII89_12975	COG1126	abc transporter atp-binding protein
GII89_12980	COG0765	amino acid transport
GII89_12985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GII89_12995	COG1597	lipid kinase activity
GII89_13000	COG2814	Major facilitator Superfamily
GII89_13005	COG4978	Transcriptional regulator
GII89_13005	COG0789	Transcriptional regulator
GII89_13010	COG0508	dehydrogenase complex catalyzes the overall conversion of
GII89_13015	COG0022	dehydrogenase e1 component
GII89_13020	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GII89_13025	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GII89_13030	COG3426	butyrate kinase activity
GII89_13035	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GII89_13040	COG0280	phosphate acetyltransferase
GII89_13045	COG3829	transcription factor binding
GII89_13045	COG3290	protein histidine kinase activity
GII89_13055	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GII89_13060	COG2079	MmgE PrpD family protein
GII89_13065	COG0372	Belongs to the citrate synthase family
GII89_13070	COG1960	acyl-CoA dehydrogenase activity
GII89_13075	COG1250	3-hydroxyacyl-CoA dehydrogenase
GII89_13080	COG0183	Belongs to the thiolase family
GII89_13085	COG0584	glycerophosphoryl diester phosphodiesterase
GII89_13090	COG0860	N-Acetylmuramoyl-L-alanine amidase
GII89_13105	COG1902	pentaerythritol trinitrate reductase activity
GII89_13110	COG0745	RESPONSE REGULATOR receiver
GII89_13115	COG0750	zinc metalloprotease
GII89_13120	COG0497	DNA recombination
GII89_13125	COG1438	arginine binding
GII89_13130	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GII89_13135	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GII89_13140	COG0142	geranyltranstransferase activity
GII89_13145	COG1722	exodeoxyribonuclease VII activity
GII89_13150	COG1570	exodeoxyribonuclease VII activity
GII89_13155	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GII89_13160	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GII89_13165	COG1302	Protein conserved in bacteria
GII89_13170	COG0439	Biotin carboxylase
GII89_13175	COG0511	ligase activity, forming carbon-carbon bonds
GII89_13215	COG3854	ATPases associated with a variety of cellular activities
GII89_13225	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GII89_13230	COG0006	proline dipeptidase activity
GII89_13235	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GII89_13245	COG3872	metal-dependent enzyme
GII89_13255	COG1752	Esterase of the alpha-beta hydrolase superfamily
GII89_13260	COG1321	iron dependent repressor
GII89_13265	COG0095	Lipoate-protein ligase
GII89_13270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GII89_13275	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GII89_13280	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GII89_13285	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GII89_13290	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GII89_13305	COG1396	sequence-specific DNA binding
GII89_13315	COG0681	Belongs to the peptidase S26 family
GII89_13340	COG4940	Competence protein ComGF
GII89_13350	COG4970	Tfp pilus assembly protein FimT
GII89_13355	COG4537	Required for transformation and DNA binding
GII89_13360	COG1459	type II secretion system
GII89_13365	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GII89_13370	COG0598	Magnesium transport protein CorA
GII89_13375	COG1253	flavin adenine dinucleotide binding
GII89_13380	COG1366	Belongs to the anti-sigma-factor antagonist family
GII89_13390	COG1393	Belongs to the ArsC family
GII89_13400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GII89_13410	COG0011	TIGRFAM Protein of
GII89_13420	COG2866	Carboxypeptidase
GII89_13425	COG1368	sulfuric ester hydrolase activity
GII89_13430	COG1940	carbohydrate kinase activity
GII89_13435	COG4483	Protein conserved in bacteria
GII89_13440	COG0705	Rhomboid family
GII89_13440	COG0457	Tetratricopeptide repeat
GII89_13450	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GII89_13455	COG0267	Belongs to the bacterial ribosomal protein bL33 family
GII89_13460	COG0438	transferase activity, transferring glycosyl groups
GII89_13475	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GII89_13480	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GII89_13485	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GII89_13490	COG0581	inorganic phosphate transmembrane transporter activity
GII89_13495	COG0573	inorganic phosphate transmembrane transporter activity
GII89_13500	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GII89_13510	COG0477	Major facilitator Superfamily
GII89_13515	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GII89_13520	COG2839	Protein conserved in bacteria
GII89_13525	COG5521	maltodextrose utilization protein MalA
GII89_13535	COG1388	LysM domain
GII89_13540	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GII89_13545	COG4709	membrane
GII89_13550	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
GII89_13555	COG0735	belongs to the Fur family
GII89_13560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GII89_13570	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GII89_13575	COG0513	Belongs to the DEAD box helicase family
GII89_13585	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GII89_13590	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GII89_13595	COG2384	SAM-dependent methyltransferase
GII89_13600	COG2010	Cytochrome c
GII89_13605	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GII89_13610	COG0358	DNA primase activity
GII89_13615	COG1671	Belongs to the UPF0178 family
GII89_13620	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GII89_13625	COG0517	IMP dehydrogenase activity
GII89_13630	COG0751	glycine-tRNA ligase activity
GII89_13635	COG0752	glycyl-tRNA synthetase alpha subunit
GII89_13640	COG1381	Involved in DNA repair and RecF pathway recombination
GII89_13650	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GII89_13655	COG0295	cytidine deaminase activity
GII89_13660	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GII89_13665	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GII89_13670	COG1480	7TM receptor with intracellular HD hydrolase
GII89_13675	COG1702	phosphate starvation-inducible protein PhoH
GII89_13680	COG0561	phosphatase activity
GII89_13695	COG4864	UPF0365 protein
GII89_13700	COG1030	water channel activity
GII89_13705	COG1610	YqeY-like protein
GII89_13710	COG0828	Belongs to the bacterial ribosomal protein bS21 family
GII89_13715	COG1283	sodium-dependent phosphate transmembrane transporter activity
GII89_13720	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GII89_13725	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GII89_13730	COG2264	protein methyltransferase activity
GII89_13735	COG0484	heat shock protein binding
GII89_13740	COG0443	Heat shock 70 kDa protein
GII89_13745	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GII89_13750	COG1420	regulation of RNA biosynthetic process
GII89_13755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GII89_13760	COG0481	GTPase activity
GII89_13770	COG0860	N-Acetylmuramoyl-L-alanine amidase
GII89_13775	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GII89_13780	COG0268	Binds directly to 16S ribosomal RNA
GII89_13785	COG1466	dna polymerase III delta subunit
GII89_13800	COG0658	competence protein
GII89_13800	COG2333	competence protein COMEC
GII89_13805	COG2131	deaminase
GII89_13810	COG1596	polysaccharide export
GII89_13810	COG1555	photosystem II stabilization
GII89_13815	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GII89_13820	COG2226	methyltransferase
GII89_13825	COG0799	negative regulation of ribosome biogenesis
GII89_13830	COG1713	HD superfamily hydrolase involved in NAD metabolism
GII89_13835	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GII89_13840	COG1534	Rna-binding protein
GII89_13845	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GII89_13850	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GII89_13855	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GII89_13865	COG2755	lipolytic protein G-D-S-L family
GII89_13870	COG5632	N-Acetylmuramoyl-L-alanine amidase
GII89_13870	COG3409	Peptidoglycan-binding domain 1 protein
GII89_13875	COG0398	Pfam SNARE associated Golgi protein
GII89_13880	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GII89_13890	COG3209	COG3209 Rhs family protein
GII89_13900	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GII89_13905	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GII89_13910	COG0798	PFAM Bile acid sodium symporter
GII89_13915	COG0346	lactoylglutathione lyase activity
GII89_13920	COG0640	Transcriptional regulator
GII89_13925	COG3403	YqcI/YcgG family
GII89_13930	COG0457	Tetratricopeptide repeat
GII89_13945	COG5444	nuclease activity
GII89_13970	COG3409	Peptidoglycan-binding domain 1 protein
GII89_13970	COG5632	N-Acetylmuramoyl-L-alanine amidase
GII89_13975	COG4824	toxin secretion phage lysis holin
GII89_14005	COG3778	Protein conserved in bacteria
GII89_14010	COG3299	homolog of phage Mu protein gp47
GII89_14015	COG3628	GPW Gp25 family protein
GII89_14025	COG4193	domain, Protein
GII89_14030	COG1652	LysM domain
GII89_14035	COG3953	SLT domain
GII89_14035	COG5280	Phage tail tape measure protein TP901
GII89_14100	COG4653	Phage capsid family
GII89_14105	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GII89_14115	COG2369	cell adhesion
GII89_14120	COG5518	Phage portal protein
GII89_14125	COG1783	phage Terminase large subunit
GII89_14130	COG5484	DNA packaging
GII89_14140	COG3677	Transposase
GII89_14155	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
GII89_14165	COG1484	DNA-dependent DNA replication
GII89_14170	COG3935	DnaD domain protein
GII89_14175	COG3723	Recombinational DNA repair protein, rece pathway
GII89_14180	COG5377	YqaJ viral recombinase family
GII89_14210	COG1476	TRANSCRIPTIONal
GII89_14215	COG3620	sequence-specific DNA binding
GII89_14225	COG0563	adenylate kinase activity
GII89_14230	COG2856	Zn peptidase
GII89_14255	COG3223	Belongs to the PsiE family
GII89_14260	COG0642	Histidine kinase
GII89_14260	COG5002	protein histidine kinase activity
GII89_14265	COG0745	RESPONSE REGULATOR receiver
GII89_14270	COG2311	Membrane
GII89_14280	COG0454	-acetyltransferase
GII89_14285	COG2249	NAD(P)H dehydrogenase (quinone) activity
GII89_14295	COG0730	response to heat
GII89_14300	COG0425	Belongs to the sulfur carrier protein TusA family
GII89_14305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GII89_14305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GII89_14315	COG0425	Belongs to the sulfur carrier protein TusA family
GII89_14315	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GII89_14325	COG2210	Belongs to the sulfur carrier protein TusA family
GII89_14330	COG1937	Protein conserved in bacteria
GII89_14335	COG0662	Cupin 2, conserved barrel domain protein
GII89_14345	COG0789	Transcriptional regulator
GII89_14345	COG4978	Transcriptional regulator
GII89_14350	COG2814	Major facilitator Superfamily
GII89_14355	COG0456	acetyltransferase
GII89_14360	COG1253	flavin adenine dinucleotide binding
GII89_14370	COG0697	spore germination
GII89_14375	COG0583	DNA-binding transcription factor activity
GII89_14380	COG2072	flavoprotein involved in K transport
GII89_14385	COG1230	cation diffusion facilitator family transporter
GII89_14390	COG1942	4-Oxalocrotonate Tautomerase
GII89_14395	COG0583	DNA-binding transcription factor activity
GII89_14405	COG1114	Component of the transport system for branched-chain amino acids
GII89_14410	COG1687	branched-chain amino acid
GII89_14415	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GII89_14420	COG1522	sequence-specific DNA binding
GII89_14425	COG2732	(Barnase) inhibitor
GII89_14430	COG2124	cytochrome p450
GII89_14435	COG1335	isochorismatase
GII89_14445	COG2318	DinB family
GII89_14455	COG2070	2-Nitropropane dioxygenase
GII89_14460	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GII89_14480	COG3443	Belongs to the bacterial solute-binding protein 9 family
GII89_14485	COG1595	DNA-templated transcription, initiation
GII89_14490	COG0667	Aldo Keto reductase
GII89_14495	COG2851	Citrate transporter
GII89_14500	COG0583	DNA-binding transcription factor activity
GII89_14505	COG2828	Protein conserved in bacteria
GII89_14510	COG3409	Peptidoglycan-binding domain 1 protein
GII89_14515	COG5566	PFAM Mor transcription activator
GII89_14520	COG0596	Alpha beta hydrolase
GII89_14525	COG4991	sh3 domain protein
GII89_14530	COG4991	sh3 domain protein
GII89_14540	COG0346	lactoylglutathione lyase activity
GII89_14550	COG5577	PFAM Coat F domain
GII89_14555	COG1063	alcohol dehydrogenase
GII89_14565	COG5577	PFAM Coat F domain
GII89_14570	COG0789	Transcriptional regulator
GII89_14580	COG1064	alcohol dehydrogenase
GII89_14585	COG0693	protein deglycase activity
GII89_14590	COG1621	beta-fructofuranosidase activity
GII89_14595	COG3716	PTS system mannose fructose sorbose family IID component
GII89_14600	COG3715	PTS system
GII89_14605	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII89_14610	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII89_14615	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GII89_14615	COG3933	PFAM sigma-54 factor interaction domain-containing protein
GII89_14625	COG1113	amino acid transport
GII89_14630	COG1280	lysine exporter protein (LysE YggA)
GII89_14635	COG1378	Sugar-specific transcriptional regulator TrmB
GII89_14640	COG1595	DNA-templated transcription, initiation
GII89_14650	COG2755	lipolytic protein G-D-S-L family
GII89_14650	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GII89_14660	COG2124	cytochrome p450
GII89_14660	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GII89_14665	COG1309	transcriptional regulator
GII89_14670	COG2226	methyltransferase
GII89_14685	COG2116	formate transmembrane transporter activity
GII89_14690	COG5609	conserved protein (DUF2294)
GII89_14695	COG3383	formate dehydrogenase (NAD+) activity
GII89_14700	COG2427	Protein of unknown function (DUF1641)
GII89_14710	COG0626	cystathionine gamma-synthase activity
GII89_14715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GII89_14720	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GII89_14725	COG2226	methyltransferase
GII89_14740	COG0768	penicillin binding
GII89_14745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GII89_14750	COG0572	uridine kinase
GII89_14770	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GII89_14775	COG3906	Belongs to the UPF0473 family
GII89_14780	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GII89_14785	COG4472	Bacterial protein of unknown function (DUF965)
GII89_14790	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GII89_14795	COG0628	permease
GII89_14800	COG1126	abc transporter atp-binding protein
GII89_14805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GII89_14810	COG0765	amino acid transport
GII89_14815	COG0765	amino acid transport
GII89_14830	COG3881	PFAM PRC-barrel domain
GII89_14835	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GII89_14840	COG0457	Tetratricopeptide repeat
GII89_14845	COG0482	sulfurtransferase activity
GII89_14850	COG1104	cysteine desulfurase activity
GII89_14855	COG1959	2 iron, 2 sulfur cluster binding
GII89_14860	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GII89_14865	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GII89_14875	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GII89_14880	COG0124	histidyl-tRNA synthetase
GII89_14890	COG0860	N-Acetylmuramoyl-L-alanine amidase
GII89_14890	COG3103	Sh3 type 3 domain protein
GII89_14890	COG4991	sh3 domain protein
GII89_14895	COG1490	D-aminoacyl-tRNA deacylase activity
GII89_14900	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GII89_14905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GII89_14910	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GII89_14910	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GII89_14915	COG5416	Lipopolysaccharide assembly protein A domain
GII89_14920	COG0490	domain, Protein
GII89_14925	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GII89_14925	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GII89_14935	COG2244	polysaccharide biosynthetic process
GII89_14940	COG2323	membrane
GII89_14950	COG1862	Preprotein translocase
GII89_14955	COG0343	queuine tRNA-ribosyltransferase activity
GII89_14960	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GII89_14970	COG2255	four-way junction helicase activity
GII89_14975	COG0632	four-way junction helicase activity
GII89_14985	COG2814	Major facilitator Superfamily
GII89_14990	COG0673	inositol 2-dehydrogenase activity
GII89_14995	COG2112	serine threonine protein kinase
GII89_15015	COG1115	amino acid carrier protein
GII89_15020	COG0217	transcriptional regulatory protein
GII89_15030	COG1388	LysM domain
GII89_15035	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GII89_15040	COG0157	Belongs to the NadC ModD family
GII89_15045	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GII89_15050	COG1104	cysteine desulfurase activity
GII89_15055	COG1827	regulation of RNA biosynthetic process
GII89_15060	COG0077	Prephenate dehydratase
GII89_15065	COG4492	Belongs to the UPF0735 family
GII89_15070	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GII89_15075	COG3290	protein histidine kinase activity
GII89_15085	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GII89_15090	COG2868	ribosomal protein
GII89_15095	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GII89_15100	COG1994	Peptidase M50
GII89_15105	COG0739	heme binding
GII89_15110	COG2894	cell division
GII89_15115	COG0850	regulation of cytokinetic process
GII89_15120	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GII89_15125	COG1792	Involved in formation and maintenance of cell shape
GII89_15130	COG1077	Cell shape determining protein MreB Mrl
GII89_15135	COG2003	Belongs to the UPF0758 family
GII89_15140	COG0424	maF-like protein
GII89_15150	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GII89_15155	COG0285	dihydrofolate synthase activity
GII89_15160	COG0525	valine-tRNA ligase activity
GII89_15170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GII89_15175	COG1388	LysM domain
GII89_15180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GII89_15185	COG0113	porphobilinogen synthase activity
GII89_15190	COG1587	Uroporphyrinogen-III synthase
GII89_15195	COG0181	hydroxymethylbilane synthase activity
GII89_15200	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GII89_15205	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GII89_15215	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GII89_15220	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GII89_15225	COG0470	DNA polymerase III
GII89_15225	COG1067	ATP-dependent peptidase activity
GII89_15230	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GII89_15235	COG0544	peptidyl-prolyl cis-trans isomerase activity
GII89_15240	COG1477	protein flavinylation
GII89_15240	COG0457	Tetratricopeptide repeat
GII89_15245	COG0066	3-isopropylmalate dehydratase activity
GII89_15250	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GII89_15255	COG0473	3-isopropylmalate dehydrogenase activity
GII89_15260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GII89_15265	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GII89_15270	COG0440	acetolactate synthase activity
GII89_15275	COG0028	Belongs to the TPP enzyme family
GII89_15285	COG0454	-acetyltransferase
GII89_15290	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
GII89_15300	COG0622	Phosphoesterase
GII89_15305	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GII89_15310	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GII89_15315	COG5401	PFAM Sporulation and spore germination
GII89_15320	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GII89_15325	COG1846	Transcriptional regulator
GII89_15330	COG2197	response regulator
GII89_15335	COG0824	Thioesterase
GII89_15340	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GII89_15345	COG1053	succinate dehydrogenase
GII89_15350	COG2009	succinate dehydrogenase
GII89_15355	COG1719	4-vinyl reductase, 4VR
GII89_15360	COG0527	aspartate kinase activity
GII89_15365	COG0322	excinuclease ABC activity
GII89_15370	COG3118	belongs to the thioredoxin family
GII89_15375	COG3534	alpha-L-arabinofuranosidase
GII89_15380	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GII89_15385	COG2086	electron transfer activity
GII89_15390	COG1024	Enoyl-CoA hydratase
GII89_15395	COG1309	transcriptional regulator
GII89_15400	COG0318	PFAM AMP-dependent synthetase and ligase
GII89_15405	COG3766	membrane
GII89_15410	COG1193	negative regulation of DNA recombination
GII89_15415	COG1796	DNA polymerase
GII89_15415	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GII89_15420	COG1286	toxin biosynthetic process
GII89_15425	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GII89_15430	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GII89_15435	COG0072	phenylalanine-tRNA ligase activity
GII89_15435	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GII89_15440	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GII89_15450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GII89_15460	COG3835	regulator
GII89_15465	COG0277	FAD linked oxidase domain protein
GII89_15470	COG0247	lactate metabolic process
GII89_15475	COG0346	lactoylglutathione lyase activity
GII89_15485	COG1966	Carbon starvation protein
GII89_15490	COG3534	alpha-L-arabinofuranosidase
GII89_15495	COG0395	ABC-type sugar transport system, permease component
GII89_15500	COG1175	transmembrane transport
GII89_15505	COG1653	transport
GII89_15510	COG0371	Dehydrogenase
GII89_15515	COG0647	UMP catabolic process
GII89_15520	COG0235	Class ii aldolase
GII89_15525	COG1069	ribulokinase activity
GII89_15530	COG2160	L-arabinose isomerase activity
GII89_15535	COG3507	Belongs to the glycosyl hydrolase 43 family
GII89_15540	COG1363	Peptidase, m42
GII89_15550	COG3326	Membrane
GII89_15555	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GII89_15560	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GII89_15565	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GII89_15575	COG1346	cytolysis
GII89_15580	COG1380	Effector of murein hydrolase LrgA
GII89_15585	COG3279	Response regulator of the LytR AlgR family
GII89_15590	COG3275	phosphorelay sensor kinase activity
GII89_15600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GII89_15610	COG0398	Pfam SNARE associated Golgi protein
GII89_15615	COG1484	DNA-dependent DNA replication
GII89_15620	COG3611	Membrane attachment protein
GII89_15625	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GII89_15630	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GII89_15635	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GII89_15640	COG1733	regulation of RNA biosynthetic process
GII89_15645	COG2814	Major facilitator Superfamily
GII89_15650	COG0656	L-ascorbic acid biosynthetic process
GII89_15655	COG0237	dephospho-CoA kinase activity
GII89_15660	COG1971	Probably functions as a manganese efflux pump
GII89_15665	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GII89_15670	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GII89_15670	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GII89_15675	COG5002	protein histidine kinase activity
GII89_15680	COG0745	RESPONSE REGULATOR receiver
GII89_15685	COG0039	L-malate dehydrogenase activity
GII89_15690	COG0538	isocitrate dehydrogenase activity
GII89_15695	COG0372	Belongs to the citrate synthase family
GII89_15700	COG2707	UPF0756 membrane protein
GII89_15705	COG0628	permease
GII89_15710	COG3030	protein affecting phage T7 exclusion by the F plasmid
GII89_15715	COG0469	pyruvate kinase activity
GII89_15720	COG0205	6-phosphofructokinase activity
GII89_15725	COG0825	malonyl-CoA metabolic process
GII89_15730	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GII89_15735	COG0281	malic enzyme
GII89_15740	COG0587	DNA-directed DNA polymerase activity
GII89_15760	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GII89_15770	COG4109	DRTGG domain
GII89_15775	COG0730	response to heat
GII89_15780	COG1473	amidohydrolase
GII89_15785	COG0196	riboflavin kinase activity
GII89_15790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GII89_15795	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GII89_15800	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GII89_15805	COG1126	abc transporter atp-binding protein
GII89_15810	COG0765	amino acid transport
GII89_15815	COG0765	amino acid transport
GII89_15820	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GII89_15825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GII89_15830	COG0454	-acetyltransferase
GII89_15835	COG0583	DNA-binding transcription factor activity
GII89_15840	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GII89_15845	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_15855	COG0165	Argininosuccinate lyase
GII89_15860	COG0137	argininosuccinate synthase activity
GII89_15865	COG0521	Mo-molybdopterin cofactor biosynthetic process
GII89_15870	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GII89_15880	COG0827	DNA restriction-modification system
GII89_15885	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GII89_15890	COG3874	Sporulation protein YtfJ
GII89_15900	COG1714	RDD family
GII89_15905	COG0616	signal peptide processing
GII89_15910	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GII89_15915	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GII89_15920	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GII89_15930	COG0301	tRNA thio-modification
GII89_15935	COG1104	cysteine desulfurase activity
GII89_15940	COG1114	Component of the transport system for branched-chain amino acids
GII89_15945	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GII89_15950	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GII89_15955	COG1309	transcriptional regulator
GII89_15960	COG1956	GAF domain-containing protein
GII89_15965	COG2203	Gaf domain
GII89_15965	COG2199	diguanylate cyclase activity
GII89_15975	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GII89_15980	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GII89_15985	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GII89_15990	COG0454	-acetyltransferase
GII89_15995	COG0517	IMP dehydrogenase activity
GII89_16000	COG0123	including yeast histone deacetylase and acetoin utilization protein
GII89_16005	COG1360	Flagellar Motor Protein
GII89_16010	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GII89_16015	COG1609	Transcriptional regulator
GII89_16020	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GII89_16020	COG1605	Chorismate mutase
GII89_16025	COG3118	belongs to the thioredoxin family
GII89_16030	COG4980	gas vesicle protein
GII89_16035	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GII89_16040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GII89_16045	COG1674	ftsk spoiiie
GII89_16050	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GII89_16055	COG4848	Belongs to the UPF0354 family
GII89_16060	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII89_16075	COG1363	Peptidase, m42
GII89_16080	COG5584	Small secreted protein
GII89_16085	COG0281	malic enzyme
GII89_16090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GII89_16095	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GII89_16105	COG0510	thiamine kinase activity
GII89_16110	COG1523	belongs to the glycosyl hydrolase 13 family
GII89_16115	COG1597	lipid kinase activity
GII89_16125	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GII89_16130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GII89_16135	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GII89_16140	COG2252	PERMEase
GII89_16145	COG4473	ABC transporter
GII89_16150	COG1131	(ABC) transporter
GII89_16155	COG1349	DNA-binding transcription factor activity
GII89_16160	COG1187	pseudouridine synthase activity
GII89_16165	COG2244	polysaccharide biosynthetic process
GII89_16170	COG2081	HI0933 family
GII89_16175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GII89_16185	COG5578	integral membrane protein
GII89_16190	COG0673	inositol 2-dehydrogenase activity
GII89_16195	COG1653	transport
GII89_16200	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GII89_16205	COG4209	transmembrane transport
GII89_16210	COG2207	Transcriptional regulator
GII89_16215	COG1653	transport
GII89_16220	COG0395	ABC-type sugar transport system, permease component
GII89_16225	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GII89_16230	COG2124	cytochrome p450
GII89_16235	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GII89_16240	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
GII89_16245	COG0156	8-amino-7-oxononanoate synthase activity
GII89_16250	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GII89_16255	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
GII89_16260	COG1073	alpha beta
GII89_16285	COG1486	melibiose metabolic process
GII89_16290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GII89_16295	COG0495	leucyl-tRNA aminoacylation
GII89_16305	COG2202	Pas domain
GII89_16305	COG1366	Belongs to the anti-sigma-factor antagonist family
GII89_16310	COG2814	Major facilitator Superfamily
GII89_16315	COG2433	Pfam Transposase IS66
GII89_16320	COG0577	efflux transmembrane transporter activity
GII89_16325	COG1136	(ABC) transporter
GII89_16330	COG2205	protein histidine kinase activity
GII89_16335	COG0745	RESPONSE REGULATOR receiver
GII89_16340	COG0577	efflux transmembrane transporter activity
GII89_16345	COG1136	(ABC) transporter
GII89_16360	COG1131	(ABC) transporter
GII89_16365	COG1725	Transcriptional regulator
GII89_16380	COG1242	4 iron, 4 sulfur cluster binding
GII89_16385	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GII89_16395	COG2267	carboxylic ester hydrolase activity
GII89_16400	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GII89_16405	COG1113	amino acid transport
GII89_16410	COG0367	asparagine synthase
GII89_16415	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GII89_16420	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GII89_16430	COG1506	peptidase
GII89_16435	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GII89_16440	COG1116	anion transmembrane transporter activity
GII89_16445	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GII89_16450	COG0494	nUDIX hydrolase
GII89_16455	COG4824	toxin secretion phage lysis holin
GII89_16460	COG0783	Belongs to the Dps family
GII89_16475	COG1854	S-ribosylhomocysteine lyase activity
GII89_16480	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GII89_16485	COG0288	reversible hydration of carbon dioxide
GII89_16490	COG0254	rRNA binding
GII89_16495	COG1271	oxidase subunit
GII89_16500	COG1294	oxidase, subunit
GII89_16510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GII89_16515	COG1321	iron dependent repressor
GII89_16515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GII89_16520	COG1121	(ABC) transporter
GII89_16525	COG0803	Belongs to the bacterial solute-binding protein 9 family
GII89_16530	COG4948	Mandelate Racemase Muconate Lactonizing
GII89_16535	COG0318	PFAM AMP-dependent synthetase and ligase
GII89_16540	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GII89_16545	COG0596	Alpha beta hydrolase
GII89_16550	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GII89_16555	COG1169	isochorismate synthase
GII89_16560	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GII89_16565	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GII89_16570	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GII89_16575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GII89_16580	COG0438	transferase activity, transferring glycosyl groups
GII89_16590	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GII89_16595	COG0438	transferase activity, transferring glycosyl groups
GII89_16600	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GII89_16605	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GII89_16610	COG0058	SHG alpha-glucan phosphorylase activity
GII89_16615	COG0297	glycogen (starch) synthase activity
GII89_16620	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GII89_16625	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GII89_16630	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GII89_16755	COG3859	Proton-coupled thiamine transporter YuaJ
GII89_16760	COG1247	-acetyltransferase
GII89_16765	COG2268	Band 7 protein
GII89_16770	COG1585	Membrane protein implicated in regulation of membrane protease activity
GII89_16775	COG2318	DinB family
GII89_16785	COG1454	alcohol dehydrogenase
GII89_16795	COG1510	regulation of RNA biosynthetic process
GII89_16805	COG0569	domain protein
GII89_16810	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GII89_16815	COG4682	membrane
GII89_16820	COG1705	Flagellar rod assembly protein muramidase FlgJ
GII89_16825	COG0477	Major facilitator Superfamily
GII89_16830	COG5553	Cysteine dioxygenase type I
GII89_16840	COG1968	undecaprenyl-diphosphatase activity
GII89_16845	COG0628	permease
GII89_16850	COG0673	inositol 2-dehydrogenase activity
GII89_16855	COG4806	L-rhamnose isomerase
GII89_16860	COG3254	rhamnose metabolic process
GII89_16865	COG1070	Carbohydrate kinase
GII89_16870	COG1349	DNA-binding transcription factor activity
GII89_16875	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_16875	COG3347	Dehydrogenase
GII89_16880	COG0840	transmembrane signaling receptor activity
GII89_16885	COG0840	transmembrane signaling receptor activity
GII89_16890	COG0840	transmembrane signaling receptor activity
GII89_16895	COG0840	transmembrane signaling receptor activity
GII89_16910	COG0432	Pfam Uncharacterised protein family UPF0047
GII89_16920	COG0366	Alpha amylase catalytic
GII89_16925	COG1253	flavin adenine dinucleotide binding
GII89_16930	COG2738	Putative neutral zinc metallopeptidase
GII89_16945	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GII89_16960	COG0166	Belongs to the GPI family
GII89_16965	COG1979	alcohol dehydrogenase
GII89_16970	COG1979	alcohol dehydrogenase
GII89_16975	COG2155	Conserved Protein
GII89_16980	COG1098	S1 RNA binding domain
GII89_16985	COG0436	Aminotransferase
GII89_16990	COG1522	sequence-specific DNA binding
GII89_16995	COG2267	carboxylic ester hydrolase activity
GII89_17005	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GII89_17010	COG2205	protein histidine kinase activity
GII89_17020	COG5018	Exonuclease
GII89_17030	COG2814	Major facilitator Superfamily
GII89_17035	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GII89_17040	COG3011	Protein conserved in bacteria
GII89_17050	COG3290	protein histidine kinase activity
GII89_17055	COG4565	transcriptional regulatory protein
GII89_17080	COG3493	citrate carrier protein
GII89_17090	COG2111	Na H antiporter
GII89_17090	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GII89_17095	COG2111	Na H antiporter
GII89_17100	COG1006	Multisubunit Na H antiporter MnhC subunit
GII89_17105	COG0651	ATP synthesis coupled electron transport
GII89_17110	COG1863	multisubunit Na H antiporter MnhE subunit
GII89_17115	COG2212	antiporter activity
GII89_17120	COG1320	monovalent cation:proton antiporter activity
GII89_17125	COG2050	protein possibly involved in aromatic compounds catabolism
GII89_17130	COG2197	response regulator
GII89_17135	COG4585	Histidine kinase
GII89_17145	COG0142	geranyltranstransferase activity
GII89_17165	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GII89_17170	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GII89_17175	COG1335	isochorismatase
GII89_17180	COG5506	Protein of unknown function (DUF1694)
GII89_17195	COG0628	permease
GII89_17210	COG1418	mRNA catabolic process
GII89_17215	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_17225	COG1511	domain protein
GII89_17230	COG0433	COG0433 Predicted ATPase
GII89_17230	COG1674	ftsk spoiiie
GII89_17235	COG4499	WXG100 protein secretion system (Wss), protein YukC
GII89_17240	COG5417	Belongs to the EsaB family
GII89_17245	COG4842	Belongs to the WXG100 family
GII89_17250	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GII89_17250	COG2508	Transcriptional regulator
GII89_17255	COG0686	Belongs to the AlaDH PNT family
GII89_17260	COG5634	Uncharacterized conserved protein (DUF2278)
GII89_17265	COG3251	PFAM MbtH domain protein
GII89_17270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII89_17275	COG1535	isochorismatase
GII89_17275	COG3433	isochorismatase activity
GII89_17280	COG1021	2,3-dihydroxybenzoate-AMP ligase
GII89_17285	COG1169	isochorismate synthase
GII89_17290	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_17295	COG2819	hydrolase of the alpha beta superfamily
GII89_17300	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GII89_17305	COG1268	BioY protein
GII89_17310	COG2056	Na+-H+ antiporter family
GII89_17315	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GII89_17320	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GII89_17325	COG3584	3D domain protein
GII89_17340	COG1252	NADH dehydrogenase
GII89_17345	COG0492	ferredoxin-NADP+ reductase activity
GII89_17355	COG0516	GMP reductase activity
GII89_17360	COG2808	Putative FMN-binding domain
GII89_17365	COG0456	acetyltransferase
GII89_17370	COG0316	Belongs to the HesB IscA family
GII89_17375	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GII89_17380	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GII89_17385	COG4844	belongs to the
GII89_17390	COG1252	NADH dehydrogenase
GII89_17395	COG4837	Protein of unknown function (DUF1462)
GII89_17400	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GII89_17405	COG0823	Involved in the tonB-independent uptake of proteins
GII89_17405	COG1506	peptidase
GII89_17405	COG4946	Tricorn protease homolog
GII89_17410	COG0083	homoserine kinase activity
GII89_17415	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GII89_17420	COG0460	homoserine dehydrogenase
GII89_17425	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GII89_17430	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GII89_17435	COG0647	UMP catabolic process
GII89_17440	COG2445	Protein of unknown function DUF86
GII89_17445	COG4470	Protein conserved in bacteria
GII89_17455	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GII89_17460	COG0739	heme binding
GII89_17470	COG3377	Domain of unknown function (DUF1805)
GII89_17475	COG0737	Belongs to the 5'-nucleotidase family
GII89_17480	COG0730	response to heat
GII89_17485	COG1801	Protein of unknown function DUF72
GII89_17495	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GII89_17500	COG2508	Transcriptional regulator
GII89_17505	COG2233	PERMEase
GII89_17510	COG2233	PERMEase
GII89_17515	COG3648	Uricase
GII89_17515	COG3195	allantoin biosynthetic process
GII89_17520	COG2351	hydroxyisourate hydrolase activity
GII89_17530	COG2080	2 iron, 2 sulfur cluster binding
GII89_17535	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GII89_17540	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GII89_17545	COG2068	MobA-Related Protein
GII89_17550	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GII89_17555	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GII89_17560	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GII89_17570	COG2356	endonuclease I
GII89_17575	COG3842	ATPase activity
GII89_17580	COG2188	Transcriptional regulator
GII89_17585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GII89_17590	COG0395	ABC-type sugar transport system, permease component
GII89_17595	COG1175	transmembrane transport
GII89_17600	COG1653	transport
GII89_17605	COG2222	sugar isomerase
GII89_17610	COG0322	excinuclease ABC activity
GII89_17615	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GII89_17630	COG0346	lactoylglutathione lyase activity
GII89_17635	COG0640	Transcriptional regulator
GII89_17640	COG0719	Fe-S assembly protein
GII89_17645	COG0822	iron-sulfur transferase activity
GII89_17650	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GII89_17655	COG0719	Fe-S assembly protein
GII89_17660	COG0396	ATPase activity
GII89_17670	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GII89_17675	COG1464	Belongs to the NlpA lipoprotein family
GII89_17680	COG2011	ABC-type metal ion transport system permease component
GII89_17685	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GII89_17695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GII89_17700	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GII89_17710	COG0509	glycine decarboxylation via glycine cleavage system
GII89_17715	COG1393	Belongs to the ArsC family
GII89_17720	COG1960	acyl-CoA dehydrogenase activity
GII89_17725	COG0183	Belongs to the thiolase family
GII89_17730	COG1024	Enoyl-CoA hydratase
GII89_17730	COG1250	3-hydroxyacyl-CoA dehydrogenase
GII89_17740	COG0506	proline dehydrogenase activity
GII89_17750	COG5577	PFAM Coat F domain
GII89_17755	COG1846	Transcriptional regulator
GII89_17760	COG0477	Major facilitator Superfamily
GII89_17765	COG1942	4-Oxalocrotonate Tautomerase
GII89_17775	COG0583	DNA-binding transcription factor activity
GII89_17785	COG1120	ATPase activity
GII89_17800	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_17805	COG0783	Belongs to the Dps family
GII89_17810	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GII89_17815	COG0745	RESPONSE REGULATOR receiver
GII89_17820	COG2770	Histidine kinase
GII89_17820	COG2205	protein histidine kinase activity
GII89_17830	COG1309	transcriptional regulator
GII89_17835	COG0114	fumarate hydratase activity
GII89_17845	COG0697	spore germination
GII89_17850	COG0814	amino acid
GII89_17860	COG2197	response regulator
GII89_17865	COG4585	Histidine kinase
GII89_17870	COG4758	membrane
GII89_17875	COG3595	metallopeptidase activity
GII89_17880	COG1842	Phage shock protein A
GII89_17885	COG4758	membrane
GII89_17890	COG2814	Major facilitator Superfamily
GII89_17895	COG2096	Adenosyltransferase
GII89_17900	COG1120	ATPase activity
GII89_17905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII89_17910	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GII89_17915	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_17920	COG3386	PFAM SMP-30 Gluconolaconase
GII89_17925	COG2205	protein histidine kinase activity
GII89_17930	COG0745	RESPONSE REGULATOR receiver
GII89_17940	COG1191	sigma factor activity
GII89_17950	COG2140	Oxalate decarboxylase
GII89_17960	COG0577	efflux transmembrane transporter activity
GII89_17965	COG1136	(ABC) transporter
GII89_17970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GII89_17975	COG1120	ATPase activity
GII89_17980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII89_17985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GII89_17990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GII89_17995	COG0531	amino acid
GII89_18005	COG1988	membrane-bound metal-dependent
GII89_18010	COG1368	sulfuric ester hydrolase activity
GII89_18015	COG1910	domain protein
GII89_18020	COG0725	ABC transporter, periplasmic molybdate-binding protein
GII89_18025	COG4149	molybdate abc transporter
GII89_18030	COG0656	L-ascorbic acid biosynthetic process
GII89_18040	COG0025	NhaP-type Na H and K H
GII89_18045	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GII89_18050	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GII89_18055	COG3973	AAA domain
GII89_18060	COG2860	membrane
GII89_18065	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GII89_18070	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GII89_18075	COG2217	Heavy metal translocating P-type atpase
GII89_18080	COG2217	Heavy metal translocating P-type atpase
GII89_18085	COG2608	mercury ion transmembrane transporter activity
GII89_18090	COG1937	Protein conserved in bacteria
GII89_18095	COG0673	inositol 2-dehydrogenase activity
GII89_18100	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GII89_18105	COG1289	transmembrane transporter activity
GII89_18115	COG2076	Multidrug Resistance protein
GII89_18120	COG1309	transcriptional regulator
GII89_18125	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_18135	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GII89_18140	COG0557	exoribonuclease II activity
GII89_18145	COG1647	Serine aminopeptidase, S33
GII89_18150	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GII89_18155	COG0596	Alpha beta hydrolase
GII89_18160	COG1476	TRANSCRIPTIONal
GII89_18165	COG1396	sequence-specific DNA binding
GII89_18170	COG1396	sequence-specific DNA binding
GII89_18175	COG1733	regulation of RNA biosynthetic process
GII89_18180	COG0840	transmembrane signaling receptor activity
GII89_18185	COG1174	glycine betaine transport
GII89_18190	COG1732	Glycine betaine
GII89_18195	COG1174	glycine betaine transport
GII89_18200	COG1125	glycine betaine transport
GII89_18200	COG0517	IMP dehydrogenase activity
GII89_18205	COG1510	regulation of RNA biosynthetic process
GII89_18225	COG5658	integral membrane protein
GII89_18230	COG0640	Transcriptional regulator
GII89_18235	COG1174	glycine betaine transport
GII89_18240	COG1732	Glycine betaine
GII89_18245	COG1174	glycine betaine transport
GII89_18250	COG1125	glycine betaine transport
GII89_18250	COG0517	IMP dehydrogenase activity
GII89_18255	COG1510	regulation of RNA biosynthetic process
GII89_18260	COG2095	MarC family integral membrane protein
GII89_18270	COG3064	Membrane
GII89_18275	COG4640	response to antibiotic
GII89_18280	COG0456	acetyltransferase
GII89_18285	COG0148	phosphopyruvate hydratase activity
GII89_18290	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GII89_18295	COG0149	triose-phosphate isomerase activity
GII89_18300	COG0126	phosphoglycerate kinase activity
GII89_18305	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GII89_18310	COG2390	Transcriptional regulator
GII89_18315	COG2814	Major facilitator Superfamily
GII89_18320	COG1609	Transcriptional regulator
GII89_18325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GII89_18330	COG0583	DNA-binding transcription factor activity
GII89_18335	COG0697	spore germination
GII89_18340	COG1113	amino acid transport
GII89_18345	COG3858	chitin binding
GII89_18350	COG1556	Lactate utilization protein
GII89_18355	COG1139	Iron-sulfur cluster binding protein
GII89_18360	COG0247	lactate metabolic process
GII89_18365	COG2197	response regulator
GII89_18370	COG4585	Histidine kinase
GII89_18375	COG0842	Transport permease protein
GII89_18380	COG1131	(ABC) transporter
GII89_18385	COG0596	Alpha beta hydrolase
GII89_18390	COG2208	phosphoserine phosphatase activity
GII89_18395	COG3867	Arabinogalactan endo-beta-1,4-galactanase
GII89_18400	COG1874	Beta-galactosidase
GII89_18405	COG3833	ABC-type maltose transport systems, permease component
GII89_18410	COG1175	transmembrane transport
GII89_18415	COG2182	Extracellular solute-binding protein
GII89_18420	COG1609	Transcriptional regulator
GII89_18425	COG2186	Transcriptional regulator
GII89_18430	COG1620	l-lactate permease
GII89_18435	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GII89_18445	COG5039	Polysaccharide pyruvyl transferase
GII89_18450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GII89_18455	COG0110	maltose O-acetyltransferase activity
GII89_18460	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GII89_18465	COG2244	polysaccharide biosynthetic process
GII89_18470	COG1216	Glycosyl transferase, family 2
GII89_18475	COG5039	Polysaccharide pyruvyl transferase
GII89_18480	COG1216	Glycosyl transferase, family 2
GII89_18490	COG0438	transferase activity, transferring glycosyl groups
GII89_18495	COG1215	transferase activity, transferring glycosyl groups
GII89_18500	COG0438	transferase activity, transferring glycosyl groups
GII89_18505	COG1086	Polysaccharide biosynthesis protein
GII89_18510	COG0489	protein tyrosine kinase activity
GII89_18515	COG3944	biosynthesis protein
GII89_18520	COG1396	sequence-specific DNA binding
GII89_18525	COG2272	Belongs to the type-B carboxylesterase lipase family
GII89_18535	COG3479	Phenolic acid decarboxylase
GII89_18545	COG1794	racemase activity, acting on amino acids and derivatives
GII89_18550	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GII89_18555	COG1621	beta-fructofuranosidase activity
GII89_18560	COG1621	beta-fructofuranosidase activity
GII89_18565	COG0531	amino acid
GII89_18570	COG1309	transcriptional regulator
GII89_18575	COG2076	Multidrug Resistance protein
GII89_18580	COG2076	Multidrug Resistance protein
GII89_18590	COG0277	FAD linked oxidase domain protein
GII89_18595	COG3621	Patatin-like phospholipase
GII89_18605	COG0740	serine-type endopeptidase activity
GII89_18610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GII89_18615	COG0366	Alpha amylase catalytic
GII89_18620	COG1554	hydrolase, family 65, central catalytic
GII89_18625	COG5521	maltodextrose utilization protein MalA
GII89_18630	COG3833	ABC-type maltose transport systems, permease component
GII89_18635	COG1175	transmembrane transport
GII89_18640	COG2182	Extracellular solute-binding protein
GII89_18645	COG0366	Alpha amylase catalytic
GII89_18650	COG1609	Transcriptional regulator
GII89_18655	COG1611	Belongs to the LOG family
GII89_18660	COG1694	Mazg nucleotide pyrophosphohydrolase
GII89_18665	COG0659	secondary active sulfate transmembrane transporter activity
GII89_18670	COG0288	reversible hydration of carbon dioxide
GII89_18675	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GII89_18680	COG0577	efflux transmembrane transporter activity
GII89_18685	COG1136	(ABC) transporter
GII89_18690	COG5002	protein histidine kinase activity
GII89_18695	COG0745	RESPONSE REGULATOR receiver
GII89_18705	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GII89_18710	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII89_18715	COG1481	regulation of sporulation
GII89_18720	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GII89_18725	COG1660	Displays ATPase and GTPase activities
GII89_18730	COG1051	belongs to the nudix hydrolase family
GII89_18735	COG0492	ferredoxin-NADP+ reductase activity
GII89_18740	COG3883	PFAM NLP P60 protein
GII89_18740	COG0791	NLP P60 protein
GII89_18745	COG0457	Tetratricopeptide repeat
GII89_18750	COG1132	(ABC) transporter
GII89_18770	COG0140	phosphoribosyl-ATP diphosphatase activity
GII89_18770	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GII89_18775	COG0107	imidazoleglycerol-phosphate synthase activity
GII89_18780	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GII89_18785	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GII89_18790	COG0131	Imidazoleglycerol-phosphate dehydratase
GII89_18795	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GII89_18800	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GII89_18805	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GII89_18810	COG4990	cell redox homeostasis
GII89_18815	COG5297	Belongs to the glycosyl hydrolase family 6
GII89_18820	COG0110	maltose O-acetyltransferase activity
GII89_18825	COG0546	phosphoglycolate phosphatase activity
GII89_18830	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GII89_18835	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GII89_18840	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GII89_18845	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GII89_18850	COG0363	glucosamine-6-phosphate deaminase activity
GII89_18860	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GII89_18865	COG1846	Transcriptional regulator
GII89_18870	COG2124	cytochrome p450
GII89_18880	COG1846	Transcriptional regulator
GII89_18885	COG2814	Major facilitator Superfamily
GII89_18890	COG1950	PFAM Membrane protein of
GII89_18895	COG1983	PspC domain protein
GII89_18900	COG3595	metallopeptidase activity
GII89_18920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GII89_18925	COG0556	nucleotide-excision repair
GII89_18930	COG4897	Protein conserved in bacteria
GII89_18935	COG0574	Belongs to the PEP-utilizing enzyme family
GII89_18935	COG3848	Pyruvate phosphate dikinase
GII89_18940	COG1309	transcriptional regulator
GII89_18945	COG2814	Major facilitator Superfamily
GII89_18950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GII89_18960	COG0793	Belongs to the peptidase S41A family
GII89_18960	COG3409	Peptidoglycan-binding domain 1 protein
GII89_18965	COG2177	Part of the ABC transporter FtsEX involved in
GII89_18970	COG2884	Cell division ATP-binding protein ftsE
GII89_18975	COG2010	Cytochrome c
GII89_18980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GII89_18990	COG0653	protein targeting
GII89_18995	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GII89_19010	COG1516	flagellar protein fliS
GII89_19015	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GII89_19020	COG1334	flagellar protein FlaG
GII89_19025	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GII89_19030	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GII89_19035	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GII89_19045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GII89_19050	COG4786	Flagellar basal body rod
GII89_19050	COG1256	bacterial-type flagellum assembly
GII89_19055	COG3418	PFAM FlgN family protein
GII89_19060	COG2747	anti-sigma28 factor FlgM
GII89_19070	COG1040	competence protein
GII89_19080	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GII89_19085	COG1307	EDD domain protein, DegV family
GII89_19090	COG2197	response regulator
GII89_19095	COG4585	Histidine kinase
GII89_19100	COG1739	Uncharacterized protein family UPF0029
GII89_19105	COG1316	TRANSCRIPTIONal
GII89_19110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GII89_19115	COG0438	transferase activity, transferring glycosyl groups
GII89_19120	COG1215	transferase activity, transferring glycosyl groups
GII89_19125	COG3206	protein involved in exopolysaccharide biosynthesis
GII89_19130	COG3307	-O-antigen
GII89_19135	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GII89_19140	COG0297	glycogen (starch) synthase activity
GII89_19140	COG0438	transferase activity, transferring glycosyl groups
GII89_19145	COG2244	polysaccharide biosynthetic process
GII89_19155	COG0860	N-Acetylmuramoyl-L-alanine amidase
GII89_19155	COG2247	cell wall binding repeat
GII89_19160	COG2385	sporulation resulting in formation of a cellular spore
GII89_19160	COG2247	cell wall binding repeat
GII89_19170	COG1316	TRANSCRIPTIONal
GII89_19175	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GII89_19180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GII89_19190	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GII89_19190	COG1215	transferase activity, transferring glycosyl groups
GII89_19195	COG0463	Glycosyl transferase, family 2
GII89_19205	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GII89_19215	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GII89_19220	COG1134	teichoic acid transport
GII89_19225	COG1682	transport, permease protein
GII89_19230	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GII89_19235	COG0438	transferase activity, transferring glycosyl groups
GII89_19240	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GII89_19245	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GII89_19250	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GII89_19260	COG4193	domain, Protein
GII89_19265	COG1482	cell wall glycoprotein biosynthetic process
GII89_19270	COG0697	spore germination
GII89_19275	COG0814	amino acid
GII89_19285	COG2814	Major facilitator Superfamily
GII89_19290	COG1316	TRANSCRIPTIONal
GII89_19295	COG0561	phosphatase activity
GII89_19300	COG0791	NLP P60 protein
GII89_19310	COG2843	Capsule synthesis protein
GII89_19320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GII89_19325	COG1609	Transcriptional regulator
GII89_19330	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GII89_19335	COG1869	D-ribose catabolic process
GII89_19340	COG1129	ABC transporter
GII89_19345	COG1172	Belongs to the binding-protein-dependent transport system permease family
GII89_19350	COG1879	ABC-type sugar transport system periplasmic component
GII89_19355	COG3103	Sh3 type 3 domain protein
GII89_19365	COG2249	NAD(P)H dehydrogenase (quinone) activity
GII89_19370	COG3527	Alpha-acetolactate decarboxylase
GII89_19375	COG0028	Belongs to the TPP enzyme family
GII89_19380	COG0583	DNA-binding transcription factor activity
GII89_19385	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GII89_19400	COG5337	Spore coat protein CotH
GII89_19410	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GII89_19420	COG0405	Gamma-glutamyltransferase
GII89_19425	COG1522	sequence-specific DNA binding
GII89_19430	COG2059	Chromate
GII89_19435	COG2059	Chromate
GII89_19445	COG0655	NAD(P)H dehydrogenase (quinone) activity
GII89_19450	COG0583	DNA-binding transcription factor activity
GII89_19455	COG1515	deoxyribonuclease V activity
GII89_19460	COG2849	repeat protein
GII89_19465	COG5444	nuclease activity
GII89_19485	COG3878	Protein conserved in bacteria
GII89_19490	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GII89_19495	COG4464	protein tyrosine phosphatase activity
GII89_19500	COG0489	protein tyrosine kinase activity
GII89_19505	COG3944	biosynthesis protein
GII89_19515	COG4715	Zinc finger, swim domain protein
GII89_19520	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GII89_19525	COG0561	phosphatase activity
GII89_19530	COG1349	DNA-binding transcription factor activity
GII89_19535	COG0629	single-stranded DNA binding
GII89_19550	COG3764	Sortase (surface protein transpeptidase)
GII89_19560	COG2972	Histidine kinase
GII89_19560	COG0745	RESPONSE REGULATOR receiver
GII89_19565	COG1970	mechanosensitive ion channel activity
GII89_19570	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GII89_19575	COG0457	Tetratricopeptide repeat
GII89_19580	COG4786	Flagellar basal body rod
GII89_19585	COG4786	Flagellar basal body rod
GII89_19590	COG1077	Cell shape determining protein MreB Mrl
GII89_19595	COG1609	Transcriptional regulator
GII89_19605	COG1846	Transcriptional regulator
GII89_19610	COG2814	Major facilitator Superfamily
GII89_19615	COG3420	alginic acid biosynthetic process
GII89_19620	COG1953	Uracil, thiamine, allantoin
GII89_19625	COG0477	Major facilitator Superfamily
GII89_19630	COG1335	isochorismatase
GII89_19640	COG0004	ammonium transporteR
GII89_19645	COG0347	Belongs to the P(II) protein family
GII89_19650	COG0671	phosphoesterase, PA-phosphatase related
GII89_19660	COG0739	heme binding
GII89_19665	COG1247	-acetyltransferase
GII89_19685	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GII89_19690	COG0789	Transcriptional regulator
GII89_19700	COG2910	NAD(P)H-binding
GII89_19705	COG1959	2 iron, 2 sulfur cluster binding
GII89_19710	COG0804	urea catabolic process
GII89_19715	COG0832	Belongs to the urease beta subunit family
GII89_19720	COG0831	urea catabolic process
GII89_19735	COG3237	CsbD-like
GII89_19740	COG1994	Peptidase M50
GII89_19745	COG0457	Tetratricopeptide repeat
GII89_19750	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GII89_19755	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GII89_19765	COG2304	oxidoreductase activity
GII89_19775	COG2304	oxidoreductase activity
GII89_19780	COG2385	sporulation resulting in formation of a cellular spore
GII89_19785	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GII89_19795	COG4836	Membrane
GII89_19805	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GII89_19810	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GII89_19815	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GII89_19820	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GII89_19825	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GII89_19830	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GII89_19835	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GII89_19840	COG0356	it plays a direct role in the translocation of protons across the membrane
GII89_19850	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GII89_19855	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GII89_19860	COG4475	Protein of unknown function (DUF436)
GII89_19865	COG0698	ribose 5-phosphate isomerase
GII89_19870	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GII89_19875	COG1971	Probably functions as a manganese efflux pump
GII89_19880	COG0009	L-threonylcarbamoyladenylate synthase
GII89_19885	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GII89_19905	COG2890	protein-(glutamine-N5) methyltransferase activity
GII89_19910	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GII89_19915	COG0346	lactoylglutathione lyase activity
GII89_19920	COG0789	Transcriptional regulator
GII89_19925	COG0679	Auxin Efflux Carrier
GII89_19930	COG0281	malic enzyme
GII89_19935	COG1435	thymidine kinase activity
GII89_19940	COG0254	rRNA binding
GII89_19945	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GII89_19955	COG1494	fructose-1,6-bisphosphatase
GII89_19960	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GII89_19965	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GII89_19970	COG0191	fructose-bisphosphate aldolase activity
GII89_19975	COG2204	response regulator
GII89_19980	COG4821	SIS domain
GII89_19985	COG0504	CTP synthase activity
GII89_19990	COG3343	RNA polymerase activity
GII89_19995	COG1960	acyl-CoA dehydrogenase activity
GII89_20000	COG2181	nitrate reductase activity
GII89_20000	COG0247	lactate metabolic process
GII89_20005	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GII89_20010	COG4294	response to UV
GII89_20020	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GII89_20025	COG1132	(ABC) transporter
GII89_20030	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GII89_20040	COG2181	nitrate reductase activity
GII89_20045	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GII89_20050	COG1140	nitrate reductase beta subunit
GII89_20055	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GII89_20060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GII89_20070	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GII89_20075	COG2223	nitrite transmembrane transporter activity
GII89_20080	COG0018	arginyl-trna synthetase
GII89_20085	COG4506	Protein conserved in bacteria
GII89_20100	COG0535	radical SAM domain protein
GII89_20110	COG1131	(ABC) transporter
GII89_20115	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GII89_20120	COG0612	Peptidase, M16
GII89_20125	COG0612	Peptidase, M16
GII89_20135	COG3391	amine dehydrogenase activity
GII89_20140	COG3391	amine dehydrogenase activity
GII89_20150	COG0457	Tetratricopeptide repeat
GII89_20160	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GII89_20165	COG0010	Belongs to the arginase family
GII89_20170	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GII89_20175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GII89_20185	COG1994	Peptidase M50
GII89_20190	COG1942	4-Oxalocrotonate Tautomerase
GII89_20195	COG1846	Transcriptional regulator
GII89_20200	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GII89_20205	COG0477	Major facilitator Superfamily
GII89_20210	COG1959	2 iron, 2 sulfur cluster binding
GII89_20215	COG3465	dGTPase activity
GII89_20220	COG1078	dGTPase activity
GII89_20225	COG4844	belongs to the
GII89_20235	COG0697	spore germination
GII89_20240	COG0095	Lipoate-protein ligase
GII89_20245	COG0583	DNA-binding transcription factor activity
GII89_20250	COG0280	phosphate acetyltransferase
GII89_20260	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_20265	COG0436	Aminotransferase
GII89_20270	COG2814	Major facilitator Superfamily
GII89_20275	COG0151	Belongs to the GarS family
GII89_20280	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_20285	COG1917	Cupin 2, conserved barrel domain protein
GII89_20290	COG0077	Prephenate dehydratase
GII89_20295	COG2814	Major facilitator Superfamily
GII89_20300	COG0833	amino acid
GII89_20305	COG4187	Peptidase family M20/M25/M40
GII89_20310	COG1012	belongs to the aldehyde dehydrogenase family
GII89_20315	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GII89_20325	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GII89_20330	COG1091	dTDP-4-dehydrorhamnose reductase activity
GII89_20335	COG1088	dTDP-glucose 4,6-dehydratase activity
GII89_20340	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GII89_20345	COG3980	spore coat polysaccharide biosynthesis protein
GII89_20350	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
GII89_20355	COG2089	acid synthase
GII89_20360	COG0456	acetyltransferase
GII89_20365	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GII89_20370	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GII89_20375	COG0463	Glycosyl transferase, family 2
GII89_20385	COG2363	Small membrane protein
GII89_20390	COG2233	PERMEase
GII89_20400	COG1012	belongs to the aldehyde dehydrogenase family
GII89_20405	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GII89_20410	COG1216	Glycosyl transferase, family 2
GII89_20425	COG1695	Transcriptional regulator
GII89_20430	COG0351	phosphomethylpyrimidine kinase
GII89_20440	COG1621	beta-fructofuranosidase activity
GII89_20445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII89_20445	COG1263	PTS System
GII89_20450	COG2116	formate transmembrane transporter activity
GII89_20455	COG3711	transcriptional antiterminator
GII89_20465	COG1404	Belongs to the peptidase S8 family
GII89_20470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GII89_20475	COG0778	Nitroreductase
GII89_20480	COG0772	Belongs to the SEDS family
GII89_20490	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GII89_20495	COG1845	cytochrome c oxidase, subunit III
GII89_20500	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GII89_20505	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GII89_20510	COG2261	transglycosylase associated protein
GII89_20515	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GII89_20520	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GII89_20525	COG2246	polysaccharide biosynthetic process
GII89_20530	COG1309	transcriptional regulator
GII89_20540	COG3162	membrane
GII89_20545	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GII89_20550	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GII89_20555	COG2837	iron assimilation
GII89_20560	COG2822	iron ion transport
GII89_20565	COG0672	)-iron permease
GII89_20570	COG0352	thiamine-phosphate diphosphorylase activity
GII89_20575	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GII89_20580	COG0583	DNA-binding transcription factor activity
GII89_20585	COG1380	Effector of murein hydrolase LrgA
GII89_20590	COG1346	cytolysis
GII89_20595	COG2814	Major facilitator Superfamily
GII89_20600	COG4895	conserved protein (DUF2196)
GII89_20605	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GII89_20610	COG0346	lactoylglutathione lyase activity
GII89_20620	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GII89_20625	COG1404	Belongs to the peptidase S8 family
GII89_20630	COG1263	PTS System
GII89_20630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII89_20635	COG3711	transcriptional antiterminator
GII89_20640	COG1442	glycosyl transferase family 8
GII89_20645	COG5522	Integral membrane protein (intg_mem_TP0381)
GII89_20650	COG1846	Transcriptional regulator
GII89_20655	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GII89_20660	COG2234	aminopeptidase activity
GII89_20665	COG2357	RelA SpoT domain protein
GII89_20670	COG1575	Belongs to the MenA family. Type 1 subfamily
GII89_20685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GII89_20690	COG1696	Membrane protein involved in D-alanine export
GII89_20695	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GII89_20700	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GII89_20705	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GII89_20710	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GII89_20715	COG1486	melibiose metabolic process
GII89_20720	COG1447	Phosphotransferase system cellobiose-specific component IIA
GII89_20725	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GII89_20730	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GII89_20735	COG3711	transcriptional antiterminator
GII89_20735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GII89_20745	COG2094	Belongs to the DNA glycosylase MPG family
GII89_20750	COG0753	catalase activity
GII89_20755	COG2814	Major facilitator Superfamily
GII89_20760	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GII89_20765	COG1131	(ABC) transporter
GII89_20785	COG1595	DNA-templated transcription, initiation
GII89_20790	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GII89_20795	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GII89_20800	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GII89_20805	COG4988	ABC transporter
GII89_20810	COG1294	oxidase, subunit
GII89_20815	COG1271	oxidase subunit
GII89_20820	COG3493	citrate carrier protein
GII89_20825	COG0501	Belongs to the peptidase M48B family
GII89_20835	COG0726	polysaccharide deacetylase
GII89_20840	COG3842	ATPase activity
GII89_20845	COG2508	Transcriptional regulator
GII89_20850	COG1012	belongs to the aldehyde dehydrogenase family
GII89_20855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GII89_20865	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GII89_20870	COG1881	PFAM PEBP family protein
GII89_20875	COG0583	DNA-binding transcription factor activity
GII89_20885	COG4585	Histidine kinase
GII89_20890	COG2197	response regulator
GII89_20895	COG2195	Cleaves the N-terminal amino acid of tripeptides
GII89_20905	COG4894	glucomannan catabolic process
GII89_20910	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GII89_20915	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GII89_20920	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_20925	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GII89_20930	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GII89_20935	COG2610	gluconate transmembrane transporter activity
GII89_20940	COG0500	methyltransferase
GII89_20945	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GII89_20960	COG0753	catalase activity
GII89_20960	COG0693	protein deglycase activity
GII89_20965	COG2851	Citrate transporter
GII89_20970	COG2273	Hydrolase Family 16
GII89_20975	COG3711	transcriptional antiterminator
GII89_20985	COG2270	Major facilitator Superfamily
GII89_20990	COG0513	Belongs to the DEAD box helicase family
GII89_20995	COG3401	FG-GAP repeat protein
GII89_20995	COG2755	lipolytic protein G-D-S-L family
GII89_21050	COG3209	COG3209 Rhs family protein
GII89_21055	COG0697	spore germination
GII89_21060	COG0589	response to stress
GII89_21065	COG2723	6-phospho-beta-galactosidase activity
GII89_21070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII89_21070	COG2190	(PTS) system
GII89_21070	COG1263	PTS System
GII89_21085	COG5444	nuclease activity
GII89_21100	COG3507	Belongs to the glycosyl hydrolase 43 family
GII89_21115	COG2986	histidine ammonia-lyase
GII89_21120	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GII89_21125	COG1228	amidohydrolase
GII89_21130	COG0010	Belongs to the arginase family
GII89_21135	COG0833	amino acid
GII89_21140	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GII89_21145	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GII89_21150	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GII89_21155	COG2390	Transcriptional regulator
GII89_21165	COG3192	ethanolamine utilization protein
GII89_21170	COG2079	MmgE PrpD family protein
GII89_21180	COG1126	abc transporter atp-binding protein
GII89_21185	COG0765	amino acid transport
GII89_21190	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GII89_21210	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GII89_21215	COG0561	phosphatase activity
GII89_21245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GII89_21250	COG5294	Protein conserved in bacteria
GII89_21255	COG0577	efflux transmembrane transporter activity
GII89_21260	COG1136	(ABC) transporter
GII89_21265	COG2205	protein histidine kinase activity
GII89_21270	COG0745	RESPONSE REGULATOR receiver
GII89_21275	COG0191	fructose-bisphosphate aldolase activity
GII89_21280	COG1082	Xylose isomerase domain protein TIM barrel
GII89_21285	COG1082	Xylose isomerase domain protein TIM barrel
GII89_21290	COG0673	inositol 2-dehydrogenase activity
GII89_21295	COG2814	Major facilitator Superfamily
GII89_21300	COG1082	Xylose isomerase domain protein TIM barrel
GII89_21305	COG3962	Belongs to the TPP enzyme family
GII89_21310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GII89_21315	COG3718	enzyme involved in inositol metabolism
GII89_21320	COG1012	belongs to the aldehyde dehydrogenase family
GII89_21325	COG1349	DNA-binding transcription factor activity
GII89_21330	COG0667	Aldo Keto reductase
GII89_21345	COG2814	Major facilitator Superfamily
GII89_21350	COG0326	Molecular chaperone. Has ATPase activity
GII89_21360	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_21365	COG1309	transcriptional regulator
GII89_21370	COG1012	belongs to the aldehyde dehydrogenase family
GII89_21375	COG0456	acetyltransferase
GII89_21380	COG2850	peptidyl-arginine hydroxylation
GII89_21385	COG2226	methyltransferase
GII89_21400	COG0367	asparagine synthase
GII89_21405	COG2814	Major facilitator Superfamily
GII89_21410	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GII89_21420	COG1714	RDD family
GII89_21425	COG2311	Membrane
GII89_21430	COG1917	Cupin 2, conserved barrel domain protein
GII89_21435	COG1309	transcriptional regulator
GII89_21440	COG1028	Short-chain dehydrogenase reductase Sdr
GII89_21445	COG1846	Transcriptional regulator
GII89_21450	COG1380	Effector of murein hydrolase LrgA
GII89_21455	COG1346	cytolysis
GII89_21460	COG5039	Polysaccharide pyruvyl transferase
GII89_21465	COG1929	Belongs to the glycerate kinase type-1 family
GII89_21470	COG1802	Transcriptional regulator
GII89_21475	COG1070	Carbohydrate kinase
GII89_21480	COG2610	gluconate transmembrane transporter activity
GII89_21485	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GII89_21490	COG0450	alkyl hydroperoxide reductase
GII89_21495	COG3634	alkyl hydroperoxide reductase activity
GII89_21500	COG2723	6-phospho-beta-galactosidase activity
GII89_21505	COG2190	(PTS) system
GII89_21510	COG1263	PTS System
GII89_21510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GII89_21510	COG2190	(PTS) system
GII89_21515	COG2188	Transcriptional regulator
GII89_21530	COG1131	(ABC) transporter
GII89_21535	COG1994	Peptidase M50
GII89_21540	COG0535	radical SAM domain protein
GII89_21550	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GII89_21555	COG5293	efflux transmembrane transporter activity
GII89_21565	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GII89_21570	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GII89_21585	COG1063	alcohol dehydrogenase
GII89_21605	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
GII89_21610	COG0456	acetyltransferase
GII89_21615	COG0457	Tetratricopeptide repeat
GII89_21625	COG0010	Belongs to the arginase family
GII89_21630	COG0833	amino acid
GII89_21635	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GII89_21640	COG3829	transcription factor binding
GII89_21655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GII89_21660	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GII89_21665	COG4853	Protein conserved in bacteria
GII89_21670	COG4863	YycH protein
GII89_21675	COG5002	protein histidine kinase activity
GII89_21680	COG0745	RESPONSE REGULATOR receiver
GII89_21710	COG0346	lactoylglutathione lyase activity
GII89_21715	COG0305	Participates in initiation and elongation during chromosome replication
GII89_21730	COG3093	addiction module antidote protein HigA
GII89_21735	COG2807	transmembrane transport
GII89_21740	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GII89_21745	COG0359	binds to the 23S rRNA
GII89_21750	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GII89_21755	COG4241	membrane
GII89_21765	COG5577	PFAM Coat F domain
GII89_21770	COG1733	regulation of RNA biosynthetic process
GII89_21775	COG1227	inorganic diphosphatase activity
GII89_21790	COG2271	Major facilitator Superfamily
GII89_21825	COG1131	(ABC) transporter
GII89_21840	COG4319	ketosteroid isomerase
GII89_21845	COG1357	PFAM Pentapeptide repeats (8 copies)
GII89_21850	COG2814	Major facilitator Superfamily
GII89_21855	COG0583	DNA-binding transcription factor activity
GII89_21860	COG2153	protein acetylation
GII89_21870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GII89_21875	COG1846	Transcriptional regulator
GII89_21880	COG2153	protein acetylation
GII89_21885	COG2364	Membrane
GII89_21890	COG0456	acetyltransferase
GII89_21895	COG2315	Protein conserved in bacteria
GII89_21900	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GII89_21910	COG2814	Major facilitator Superfamily
GII89_21920	COG1331	Highly conserved protein containing a thioredoxin domain
GII89_21925	COG0789	Transcriptional regulator
GII89_21930	COG0697	spore germination
GII89_21935	COG1331	Highly conserved protein containing a thioredoxin domain
GII89_21940	COG1266	CAAX protease self-immunity
GII89_21945	COG2814	Major facilitator Superfamily
GII89_21945	COG0477	Major facilitator Superfamily
GII89_21950	COG0110	maltose O-acetyltransferase activity
GII89_21955	COG0346	lactoylglutathione lyase activity
GII89_21960	COG1609	Transcriptional regulator
GII89_21965	COG0708	Exodeoxyribonuclease III
GII89_21970	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GII89_21975	COG0629	single-stranded DNA binding
GII89_21980	COG0360	Binds together with S18 to 16S ribosomal RNA
GII89_21985	COG0012	GTP binding
GII89_21990	COG0243	molybdopterin cofactor binding
GII89_21995	COG4481	Protein conserved in bacteria
GII89_22000	COG3949	Membrane
GII89_22010	COG1475	DNA binding
GII89_22015	COG1192	Involved in chromosome partitioning
GII89_22025	COG1475	DNA binding
GII89_22030	COG0357	Ribosomal RNA small subunit methyltransferase G
GII89_22035	COG0445	tRNA wobble uridine modification
GII89_22040	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GII89_22045	COG1847	R3H domain protein
GII89_22050	COG0706	membrane insertase activity
GII89_22055	COG0594	ribonuclease P activity
GII89_22060	COG0230	Belongs to the bacterial ribosomal protein bL34 family
GII89_22120	COG5444	nuclease activity
GII89_22175	COG5280	Phage tail tape measure protein TP901
GII89_22175	COG3953	SLT domain
GII89_22265	COG0457	Tetratricopeptide repeat
GII89_22285	COG3584	3D domain protein
GII89_22285	COG1388	LysM domain
GII89_22295	COG0582	viral genome integration into host DNA
GII89_22365	COG2887	Belongs to the helicase family. UvrD subfamily
GII89_22370	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GII89_22375	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GII89_22380	COG0716	FMN binding
GII89_22420	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GII89_22455	COG0328	RNA-DNA hybrid ribonuclease activity
GII89_22475	COG0587	DNA-directed DNA polymerase activity
GII89_22495	COG0194	GDP metabolic process
GII89_22545	COG0187	DNA topoisomerase II activity