locus-tag	class	description
C2I05_00005	COG2368	4-hydroxyphenylacetate
C2I05_00010	COG4305	rare lipoprotein A
C2I05_00015	COG3619	membrane
C2I05_00020	COG3866	Pectate lyase
C2I05_00025	COG2135	peptidase activity
C2I05_00035	COG2140	Oxalate decarboxylase
C2I05_00055	COG2720	vancomycin resistance protein
C2I05_00065	COG3655	Transcriptional regulator
C2I05_00070	COG3739	integral membrane protein
C2I05_00075	COG0583	DNA-binding transcription factor activity
C2I05_00080	COG0697	spore germination
C2I05_00090	COG0693	protein deglycase activity
C2I05_00095	COG2367	Beta-lactamase
C2I05_00115	COG0574	Belongs to the PEP-utilizing enzyme family
C2I05_00115	COG3848	Pyruvate phosphate dikinase
C2I05_00120	COG0726	polysaccharide deacetylase
C2I05_00150	COG5444	nuclease activity
C2I05_00155	COG4282	regulation of fungal-type cell wall biogenesis
C2I05_00160	COG1231	oxidoreductase activity
C2I05_00165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2I05_00170	COG0662	Cupin 2, conserved barrel domain protein
C2I05_00170	COG2207	Transcriptional regulator
C2I05_00175	COG0456	acetyltransferase
C2I05_00180	COG1309	transcriptional regulator
C2I05_00185	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I05_00190	COG3708	Transcriptional regulator
C2I05_00195	COG2378	regulation of single-species biofilm formation
C2I05_00205	COG0640	Transcriptional regulator
C2I05_00215	COG2322	membrane
C2I05_00230	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2I05_00235	COG3239	Fatty acid desaturase
C2I05_00240	COG4585	Histidine kinase
C2I05_00245	COG2197	response regulator
C2I05_00250	COG1388	LysM domain
C2I05_00250	COG3584	3D domain protein
C2I05_00255	COG0514	ATP-dependent DNA helicase (RecQ)
C2I05_00270	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2I05_00275	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2I05_00290	COG0071	Belongs to the small heat shock protein (HSP20) family
C2I05_00315	COG1012	belongs to the aldehyde dehydrogenase family
C2I05_00320	COG1657	PFAM Prenyltransferase squalene oxidase
C2I05_00325	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2I05_00330	COG0733	neurotransmitter:sodium symporter activity
C2I05_00335	COG0385	Bile acid
C2I05_00340	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2I05_00345	COG0567	Dehydrogenase, E1 component
C2I05_00350	COG4548	von Willebrand factor, type A
C2I05_00355	COG0714	Associated with various cellular activities
C2I05_00360	COG2032	superoxide dismutase activity
C2I05_00365	COG0791	NLP P60 protein
C2I05_00365	COG1388	LysM domain
C2I05_00370	COG1819	glycosyl
C2I05_00375	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C2I05_00380	COG0534	Mate efflux family protein
C2I05_00385	COG1366	Belongs to the anti-sigma-factor antagonist family
C2I05_00390	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2I05_00395	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2I05_00405	COG2962	Rard protein
C2I05_00420	COG2610	gluconate transmembrane transporter activity
C2I05_00425	COG1942	4-Oxalocrotonate Tautomerase
C2I05_00430	COG1733	regulation of RNA biosynthetic process
C2I05_00435	COG0778	Nitroreductase
C2I05_00440	COG0400	carboxylic ester hydrolase activity
C2I05_00445	COG0346	lactoylglutathione lyase activity
C2I05_00455	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2I05_00460	COG3409	Peptidoglycan-binding domain 1 protein
C2I05_00460	COG0793	Belongs to the peptidase S41A family
C2I05_00465	COG2226	methyltransferase
C2I05_00475	COG1876	peptidase activity
C2I05_00480	COG0813	purine-nucleoside phosphorylase activity
C2I05_00495	COG0671	phosphoesterase, PA-phosphatase related
C2I05_00520	COG4479	Belongs to the UPF0346 family
C2I05_00580	COG1509	lysine 2,3-aminomutase activity
C2I05_00585	COG0456	acetyltransferase
C2I05_00590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2I05_00595	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2I05_00600	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2I05_00605	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2I05_00615	COG0456	acetyltransferase
C2I05_00620	COG0463	Glycosyl transferase, family 2
C2I05_00635	COG4641	Protein conserved in bacteria
C2I05_00640	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
C2I05_00645	COG1086	Polysaccharide biosynthesis protein
C2I05_00650	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2I05_00655	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2I05_00660	COG1846	Transcriptional regulator
C2I05_00665	COG0534	Mate efflux family protein
C2I05_00675	COG4698	Protein conserved in bacteria
C2I05_00680	COG2755	lipolytic protein G-D-S-L family
C2I05_00685	COG1999	signal sequence binding
C2I05_00695	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2I05_00700	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2I05_00705	COG1272	protein, Hemolysin III
C2I05_00710	COG0204	Acyl-transferase
C2I05_00715	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2I05_00720	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2I05_00730	COG2521	methyltransferase
C2I05_00730	COG2136	Putative SAM-dependent methyltransferase
C2I05_00740	COG0129	dihydroxy-acid dehydratase activity
C2I05_00745	COG1413	lyase activity
C2I05_00750	COG1418	mRNA catabolic process
C2I05_00755	COG0386	Belongs to the glutathione peroxidase family
C2I05_00760	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C2I05_00765	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2I05_00770	COG1278	Cold shock
C2I05_00790	COG0328	RNA-DNA hybrid ribonuclease activity
C2I05_00795	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2I05_00800	COG0328	RNA-DNA hybrid ribonuclease activity
C2I05_00810	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2I05_00825	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2I05_00835	COG1755	Isoprenylcysteine carboxyl methyltransferase
C2I05_00840	COG3424	synthase
C2I05_00845	COG2233	PERMEase
C2I05_00850	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2I05_00855	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C2I05_00865	COG0800	Aldolase
C2I05_00870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2I05_00875	COG1609	Transcriptional regulator
C2I05_00880	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C2I05_00885	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_00890	COG1199	ATP-dependent helicase activity
C2I05_00905	COG0116	Belongs to the methyltransferase superfamily
C2I05_00920	COG4474	Belongs to the UPF0398 family
C2I05_00930	COG3359	exonuclease
C2I05_00935	COG1205	dead DEAH box helicase
C2I05_00935	COG1111	helicase
C2I05_00940	COG2190	(PTS) system
C2I05_00945	COG0071	Belongs to the small heat shock protein (HSP20) family
C2I05_00980	COG3331	DNA recombination
C2I05_00985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2I05_00985	COG4499	WXG100 protein secretion system (Wss), protein YukC
C2I05_00995	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2I05_01000	COG3935	DnaD domain protein
C2I05_01005	COG0017	Asparaginyl-tRNA synthetase
C2I05_01010	COG0436	Aminotransferase
C2I05_01015	COG5353	protein conserved in bacteria
C2I05_01025	COG1199	ATP-dependent helicase activity
C2I05_01025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2I05_01030	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C2I05_01035	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C2I05_01040	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C2I05_01045	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C2I05_01045	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C2I05_01050	COG0617	tRNA 3'-terminal CCA addition
C2I05_01055	COG0438	transferase activity, transferring glycosyl groups
C2I05_01060	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2I05_01065	COG1803	Methylglyoxal synthase
C2I05_01070	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C2I05_01075	COG1694	Mazg nucleotide pyrophosphohydrolase
C2I05_01080	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I05_01090	COG4347	Protein of unknown function (DUF1405)
C2I05_01095	COG2010	Cytochrome c
C2I05_01095	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2I05_01100	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2I05_01105	COG0723	plastoquinol--plastocyanin reductase activity
C2I05_01115	COG5582	Belongs to the UPF0302 family
C2I05_01120	COG0457	Tetratricopeptide repeat
C2I05_01125	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C2I05_01130	COG0287	Prephenate dehydrogenase
C2I05_01140	COG0159	tryptophan synthase activity
C2I05_01145	COG0133	tryptophan synthase activity
C2I05_01150	COG0135	phosphoribosylanthranilate isomerase activity
C2I05_01160	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2I05_01165	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2I05_01170	COG4401	Chorismate mutase type I
C2I05_01175	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C2I05_01180	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C2I05_01185	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2I05_01190	COG0105	UTP biosynthetic process
C2I05_01195	COG0142	geranyltranstransferase activity
C2I05_01200	COG2226	methyltransferase
C2I05_01205	COG0142	geranyltranstransferase activity
C2I05_01215	COG0302	gtp cyclohydrolase
C2I05_01220	COG0776	regulation of translation
C2I05_01225	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2I05_01240	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C2I05_01245	COG1160	GTP binding
C2I05_01270	COG1304	FMN binding
C2I05_01275	COG0539	negative regulation of cytoplasmic translation
C2I05_01280	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C2I05_01290	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C2I05_01295	COG2959	enzyme of heme biosynthesis
C2I05_01300	COG3409	Peptidoglycan-binding domain 1 protein
C2I05_01300	COG3773	Cell wall hydrolase
C2I05_01305	COG2339	peptidase activity
C2I05_01310	COG0492	ferredoxin-NADP+ reductase activity
C2I05_01315	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2I05_01320	COG4862	establishment of competence for transformation
C2I05_01325	COG1408	metallophosphoesterase
C2I05_01335	COG1388	LysM domain
C2I05_01340	COG1266	CAAX protease self-immunity
C2I05_01345	COG0514	ATP-dependent DNA helicase (RecQ)
C2I05_01350	COG4955	Helix-turn-helix domain
C2I05_01355	COG1141	Ferredoxin
C2I05_01360	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C2I05_01365	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2I05_01370	COG0710	3-dehydroquinate dehydratase activity
C2I05_01380	COG1595	DNA-templated transcription, initiation
C2I05_01385	COG5002	protein histidine kinase activity
C2I05_01390	COG0745	RESPONSE REGULATOR receiver
C2I05_01395	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2I05_01400	COG1333	cytochrome c biogenesis protein
C2I05_01405	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2I05_01410	COG1187	pseudouridine synthase activity
C2I05_01415	COG0700	Nucleoside recognition
C2I05_01420	COG2715	membrane protein required for spore maturation
C2I05_01425	COG1686	Belongs to the peptidase S11 family
C2I05_01435	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C2I05_01440	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C2I05_01445	COG1547	Domain of unknown function (DUF309)
C2I05_01450	COG0456	acetyltransferase
C2I05_01455	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C2I05_01460	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2I05_01460	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2I05_01465	COG0307	riboflavin synthase, alpha
C2I05_01470	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2I05_01470	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2I05_01480	COG0681	Belongs to the peptidase S26 family
C2I05_01485	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
C2I05_01495	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2I05_01505	COG4086	secreted protein
C2I05_01510	COG0019	diaminopimelate decarboxylase activity
C2I05_01515	COG0697	spore germination
C2I05_01530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2I05_01550	COG1191	sigma factor activity
C2I05_01555	COG2172	sigma factor antagonist activity
C2I05_01560	COG1366	Belongs to the anti-sigma-factor antagonist family
C2I05_01565	COG1686	Belongs to the peptidase S11 family
C2I05_01570	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C2I05_01575	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C2I05_01580	COG4974	Belongs to the 'phage' integrase family
C2I05_01590	COG0735	belongs to the Fur family
C2I05_01595	COG1300	Membrane
C2I05_01605	COG0281	malic enzyme
C2I05_01610	COG1757	Na H antiporter
C2I05_01615	COG1027	Aspartate ammonia-lyase
C2I05_01620	COG0252	asparaginase activity
C2I05_01625	COG1396	sequence-specific DNA binding
C2I05_01630	COG1379	DNA repair
C2I05_01635	COG0494	nUDIX hydrolase
C2I05_01645	COG0667	Aldo Keto reductase
C2I05_01655	COG1073	alpha beta
C2I05_01665	COG4918	Iron-sulphur cluster biosynthesis
C2I05_01670	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2I05_01670	COG0456	acetyltransferase
C2I05_01675	COG2329	Antibiotic biosynthesis monooxygenase
C2I05_01680	COG0456	acetyltransferase
C2I05_01700	COG2211	Major facilitator Superfamily
C2I05_01710	COG0346	lactoylglutathione lyase activity
C2I05_01720	COG3048	D-serine ammonia-lyase activity
C2I05_01725	COG0300	oxidoreductase activity
C2I05_01730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I05_01735	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2I05_01740	COG4187	Peptidase family M20/M25/M40
C2I05_01745	COG1902	pentaerythritol trinitrate reductase activity
C2I05_01750	COG0596	Alpha beta hydrolase
C2I05_01760	COG1234	tRNA 3'-trailer cleavage
C2I05_01765	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2I05_01770	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C2I05_01775	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2I05_01790	COG3361	conserved protein (COG2071)
C2I05_01795	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2I05_01800	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2I05_01805	COG0346	lactoylglutathione lyase activity
C2I05_01810	COG1376	ErfK ybiS ycfS ynhG family protein
C2I05_01815	COG4129	membrane
C2I05_01820	COG1126	abc transporter atp-binding protein
C2I05_01825	COG0765	amino acid transport
C2I05_01830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2I05_01840	COG1597	lipid kinase activity
C2I05_01845	COG2814	Major facilitator Superfamily
C2I05_01850	COG4978	Transcriptional regulator
C2I05_01850	COG0789	Transcriptional regulator
C2I05_01855	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2I05_01860	COG0022	dehydrogenase e1 component
C2I05_01865	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2I05_01870	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2I05_01875	COG3426	butyrate kinase activity
C2I05_01880	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2I05_01885	COG0280	phosphate acetyltransferase
C2I05_01890	COG3829	transcription factor binding
C2I05_01890	COG3290	protein histidine kinase activity
C2I05_01900	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C2I05_01905	COG2079	MmgE PrpD family protein
C2I05_01910	COG0372	Belongs to the citrate synthase family
C2I05_01915	COG1960	acyl-CoA dehydrogenase activity
C2I05_01920	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2I05_01925	COG0183	Belongs to the thiolase family
C2I05_01930	COG0584	glycerophosphoryl diester phosphodiesterase
C2I05_01935	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2I05_01945	COG1902	pentaerythritol trinitrate reductase activity
C2I05_01950	COG0745	RESPONSE REGULATOR receiver
C2I05_01960	COG0750	zinc metalloprotease
C2I05_01965	COG0497	DNA recombination
C2I05_01970	COG1438	arginine binding
C2I05_01975	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C2I05_01980	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2I05_01985	COG0142	geranyltranstransferase activity
C2I05_01990	COG1722	exodeoxyribonuclease VII activity
C2I05_01995	COG1570	exodeoxyribonuclease VII activity
C2I05_02000	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C2I05_02005	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2I05_02010	COG1302	Protein conserved in bacteria
C2I05_02015	COG0439	Biotin carboxylase
C2I05_02020	COG0511	ligase activity, forming carbon-carbon bonds
C2I05_02060	COG3854	ATPases associated with a variety of cellular activities
C2I05_02070	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C2I05_02075	COG0006	proline dipeptidase activity
C2I05_02080	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C2I05_02090	COG3872	metal-dependent enzyme
C2I05_02100	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2I05_02105	COG1321	iron dependent repressor
C2I05_02110	COG0095	Lipoate-protein ligase
C2I05_02115	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2I05_02125	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2I05_02130	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2I05_02135	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2I05_02155	COG1396	sequence-specific DNA binding
C2I05_02165	COG0681	Belongs to the peptidase S26 family
C2I05_02190	COG4940	Competence protein ComGF
C2I05_02200	COG4970	Tfp pilus assembly protein FimT
C2I05_02205	COG4537	Required for transformation and DNA binding
C2I05_02210	COG1459	type II secretion system
C2I05_02215	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2I05_02225	COG0598	Magnesium transport protein CorA
C2I05_02230	COG1253	flavin adenine dinucleotide binding
C2I05_02235	COG1366	Belongs to the anti-sigma-factor antagonist family
C2I05_02245	COG1393	Belongs to the ArsC family
C2I05_02255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I05_02265	COG0011	TIGRFAM Protein of
C2I05_02275	COG2866	Carboxypeptidase
C2I05_02280	COG1368	sulfuric ester hydrolase activity
C2I05_02285	COG1940	carbohydrate kinase activity
C2I05_02290	COG4483	Protein conserved in bacteria
C2I05_02295	COG0457	Tetratricopeptide repeat
C2I05_02295	COG0705	Rhomboid family
C2I05_02305	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2I05_02315	COG0438	transferase activity, transferring glycosyl groups
C2I05_02330	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2I05_02335	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2I05_02340	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2I05_02345	COG0581	inorganic phosphate transmembrane transporter activity
C2I05_02350	COG0573	inorganic phosphate transmembrane transporter activity
C2I05_02355	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2I05_02360	COG0768	penicillin binding
C2I05_02370	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2I05_02375	COG2839	Protein conserved in bacteria
C2I05_02380	COG5521	maltodextrose utilization protein MalA
C2I05_02390	COG1388	LysM domain
C2I05_02395	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C2I05_02400	COG4709	membrane
C2I05_02405	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
C2I05_02410	COG0735	belongs to the Fur family
C2I05_02415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I05_02425	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C2I05_02430	COG0513	Belongs to the DEAD box helicase family
C2I05_02440	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C2I05_02445	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2I05_02450	COG2384	SAM-dependent methyltransferase
C2I05_02455	COG2010	Cytochrome c
C2I05_02465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2I05_02470	COG0358	DNA primase activity
C2I05_02475	COG1671	Belongs to the UPF0178 family
C2I05_02480	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C2I05_02485	COG0517	IMP dehydrogenase activity
C2I05_02490	COG0751	glycine-tRNA ligase activity
C2I05_02495	COG0752	glycyl-tRNA synthetase alpha subunit
C2I05_02500	COG1381	Involved in DNA repair and RecF pathway recombination
C2I05_02510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C2I05_02515	COG0295	cytidine deaminase activity
C2I05_02520	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2I05_02525	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C2I05_02530	COG1480	7TM receptor with intracellular HD hydrolase
C2I05_02535	COG1702	phosphate starvation-inducible protein PhoH
C2I05_02540	COG0561	phosphatase activity
C2I05_02555	COG4864	UPF0365 protein
C2I05_02560	COG1030	water channel activity
C2I05_02565	COG1610	YqeY-like protein
C2I05_02575	COG1283	sodium-dependent phosphate transmembrane transporter activity
C2I05_02580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2I05_02585	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2I05_02590	COG2264	protein methyltransferase activity
C2I05_02595	COG0484	heat shock protein binding
C2I05_02600	COG0443	Heat shock 70 kDa protein
C2I05_02605	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C2I05_02610	COG1420	regulation of RNA biosynthetic process
C2I05_02615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2I05_02620	COG0481	GTPase activity
C2I05_02630	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2I05_02635	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C2I05_02640	COG0268	Binds directly to 16S ribosomal RNA
C2I05_02645	COG1466	dna polymerase III delta subunit
C2I05_02660	COG2131	deaminase
C2I05_02665	COG1555	photosystem II stabilization
C2I05_02665	COG1596	polysaccharide export
C2I05_02670	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2I05_02675	COG2226	methyltransferase
C2I05_02680	COG0799	negative regulation of ribosome biogenesis
C2I05_02685	COG1713	HD superfamily hydrolase involved in NAD metabolism
C2I05_02690	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2I05_02695	COG1534	Rna-binding protein
C2I05_02700	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2I05_02705	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2I05_02710	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C2I05_02720	COG2755	lipolytic protein G-D-S-L family
C2I05_02725	COG3409	Peptidoglycan-binding domain 1 protein
C2I05_02725	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2I05_02730	COG0398	Pfam SNARE associated Golgi protein
C2I05_02735	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C2I05_02745	COG3209	COG3209 Rhs family protein
C2I05_02755	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2I05_02775	COG0457	Tetratricopeptide repeat
C2I05_02780	COG0758	DNA mediated transformation
C2I05_02795	COG0546	phosphoglycolate phosphatase activity
C2I05_02800	COG0457	Tetratricopeptide repeat
C2I05_02815	COG5444	nuclease activity
C2I05_02835	COG4282	regulation of fungal-type cell wall biogenesis
C2I05_02845	COG3409	Peptidoglycan-binding domain 1 protein
C2I05_02845	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2I05_02850	COG4824	toxin secretion phage lysis holin
C2I05_02880	COG3778	Protein conserved in bacteria
C2I05_02885	COG3299	homolog of phage Mu protein gp47
C2I05_02890	COG3628	GPW Gp25 family protein
C2I05_02900	COG4193	domain, Protein
C2I05_02905	COG1652	LysM domain
C2I05_02910	COG3953	SLT domain
C2I05_02910	COG5280	Phage tail tape measure protein TP901
C2I05_02970	COG4653	Phage capsid family
C2I05_02975	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C2I05_02985	COG2369	cell adhesion
C2I05_02990	COG5518	Phage portal protein
C2I05_02995	COG1783	phage Terminase large subunit
C2I05_03000	COG5484	DNA packaging
C2I05_03030	COG3677	Transposase
C2I05_03045	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C2I05_03055	COG1484	DNA-dependent DNA replication
C2I05_03060	COG3935	DnaD domain protein
C2I05_03065	COG3723	Recombinational DNA repair protein, rece pathway
C2I05_03070	COG5377	YqaJ viral recombinase family
C2I05_03095	COG1476	TRANSCRIPTIONal
C2I05_03100	COG3620	sequence-specific DNA binding
C2I05_03110	COG2856	Zn peptidase
C2I05_03125	COG0114	fumarate hydratase activity
C2I05_03130	COG0583	DNA-binding transcription factor activity
C2I05_03140	COG1819	glycosyl
C2I05_03145	COG3223	Belongs to the PsiE family
C2I05_03150	COG5002	protein histidine kinase activity
C2I05_03150	COG0642	Histidine kinase
C2I05_03155	COG0745	RESPONSE REGULATOR receiver
C2I05_03160	COG2311	Membrane
C2I05_03165	COG0454	-acetyltransferase
C2I05_03170	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2I05_03180	COG0730	response to heat
C2I05_03185	COG0425	Belongs to the sulfur carrier protein TusA family
C2I05_03190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I05_03190	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2I05_03200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2I05_03200	COG0425	Belongs to the sulfur carrier protein TusA family
C2I05_03205	COG2210	Belongs to the sulfur carrier protein TusA family
C2I05_03210	COG1937	Protein conserved in bacteria
C2I05_03225	COG0662	Cupin 2, conserved barrel domain protein
C2I05_03245	COG4978	Transcriptional regulator
C2I05_03245	COG0789	Transcriptional regulator
C2I05_03250	COG2814	Major facilitator Superfamily
C2I05_03255	COG0456	acetyltransferase
C2I05_03260	COG1253	flavin adenine dinucleotide binding
C2I05_03270	COG0697	spore germination
C2I05_03275	COG0583	DNA-binding transcription factor activity
C2I05_03280	COG2072	flavoprotein involved in K transport
C2I05_03285	COG1230	cation diffusion facilitator family transporter
C2I05_03295	COG1114	Component of the transport system for branched-chain amino acids
C2I05_03300	COG1687	branched-chain amino acid
C2I05_03305	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C2I05_03310	COG1522	sequence-specific DNA binding
C2I05_03315	COG2124	cytochrome p450
C2I05_03325	COG1335	isochorismatase
C2I05_03345	COG2318	DinB family
C2I05_03355	COG2070	2-Nitropropane dioxygenase
C2I05_03370	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2I05_03385	COG3443	Belongs to the bacterial solute-binding protein 9 family
C2I05_03390	COG1595	DNA-templated transcription, initiation
C2I05_03395	COG0667	Aldo Keto reductase
C2I05_03400	COG2851	Citrate transporter
C2I05_03405	COG0583	DNA-binding transcription factor activity
C2I05_03410	COG2828	Protein conserved in bacteria
C2I05_03415	COG3409	Peptidoglycan-binding domain 1 protein
C2I05_03420	COG5566	PFAM Mor transcription activator
C2I05_03425	COG0596	Alpha beta hydrolase
C2I05_03430	COG4991	sh3 domain protein
C2I05_03435	COG4991	sh3 domain protein
C2I05_03440	COG0346	lactoylglutathione lyase activity
C2I05_03450	COG5577	PFAM Coat F domain
C2I05_03455	COG1063	alcohol dehydrogenase
C2I05_03465	COG5577	PFAM Coat F domain
C2I05_03470	COG0789	Transcriptional regulator
C2I05_03480	COG1064	alcohol dehydrogenase
C2I05_03485	COG0693	protein deglycase activity
C2I05_03490	COG1621	beta-fructofuranosidase activity
C2I05_03495	COG3716	PTS system mannose fructose sorbose family IID component
C2I05_03500	COG3715	PTS system
C2I05_03505	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I05_03510	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I05_03515	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C2I05_03515	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2I05_03520	COG1113	amino acid transport
C2I05_03525	COG1280	lysine exporter protein (LysE YggA)
C2I05_03530	COG1378	Sugar-specific transcriptional regulator TrmB
C2I05_03535	COG1595	DNA-templated transcription, initiation
C2I05_03545	COG2755	lipolytic protein G-D-S-L family
C2I05_03545	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C2I05_03555	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2I05_03555	COG2124	cytochrome p450
C2I05_03560	COG1309	transcriptional regulator
C2I05_03565	COG2226	methyltransferase
C2I05_03575	COG2116	formate transmembrane transporter activity
C2I05_03580	COG5609	conserved protein (DUF2294)
C2I05_03585	COG3383	formate dehydrogenase (NAD+) activity
C2I05_03590	COG2427	Protein of unknown function (DUF1641)
C2I05_03600	COG0626	cystathionine gamma-synthase activity
C2I05_03605	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2I05_03610	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2I05_03615	COG2226	methyltransferase
C2I05_03630	COG0768	penicillin binding
C2I05_03635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2I05_03640	COG0572	uridine kinase
C2I05_03645	COG0826	peptidase U32
C2I05_03650	COG0826	peptidase U32
C2I05_03655	COG4122	O-methyltransferase activity
C2I05_03660	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2I05_03665	COG3906	Belongs to the UPF0473 family
C2I05_03670	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C2I05_03675	COG4472	Bacterial protein of unknown function (DUF965)
C2I05_03685	COG0628	permease
C2I05_03690	COG1126	abc transporter atp-binding protein
C2I05_03695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2I05_03700	COG0765	amino acid transport
C2I05_03705	COG0765	amino acid transport
C2I05_03720	COG3881	PFAM PRC-barrel domain
C2I05_03725	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2I05_03730	COG0457	Tetratricopeptide repeat
C2I05_03735	COG0482	sulfurtransferase activity
C2I05_03740	COG1104	cysteine desulfurase activity
C2I05_03745	COG1959	2 iron, 2 sulfur cluster binding
C2I05_03750	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2I05_03755	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2I05_03765	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C2I05_03770	COG0124	histidyl-tRNA synthetase
C2I05_03780	COG4991	sh3 domain protein
C2I05_03780	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2I05_03780	COG3103	Sh3 type 3 domain protein
C2I05_03785	COG1490	D-aminoacyl-tRNA deacylase activity
C2I05_03790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2I05_03795	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2I05_03800	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C2I05_03800	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2I05_03805	COG5416	Lipopolysaccharide assembly protein A domain
C2I05_03810	COG0490	domain, Protein
C2I05_03815	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2I05_03815	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2I05_03825	COG2244	polysaccharide biosynthetic process
C2I05_03830	COG2323	membrane
C2I05_03840	COG1862	Preprotein translocase
C2I05_03845	COG0343	queuine tRNA-ribosyltransferase activity
C2I05_03850	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C2I05_03860	COG2255	four-way junction helicase activity
C2I05_03865	COG0632	four-way junction helicase activity
C2I05_03875	COG2814	Major facilitator Superfamily
C2I05_03880	COG0673	inositol 2-dehydrogenase activity
C2I05_03885	COG2112	serine threonine protein kinase
C2I05_03900	COG1115	amino acid carrier protein
C2I05_03905	COG0217	transcriptional regulatory protein
C2I05_03915	COG1388	LysM domain
C2I05_03920	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2I05_03925	COG0157	Belongs to the NadC ModD family
C2I05_03930	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2I05_03935	COG1104	cysteine desulfurase activity
C2I05_03940	COG1827	regulation of RNA biosynthetic process
C2I05_03945	COG0077	Prephenate dehydratase
C2I05_03950	COG4492	Belongs to the UPF0735 family
C2I05_03955	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C2I05_03960	COG3290	protein histidine kinase activity
C2I05_03965	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C2I05_03970	COG2868	ribosomal protein
C2I05_03975	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C2I05_03980	COG1994	Peptidase M50
C2I05_03985	COG0739	heme binding
C2I05_03990	COG2894	cell division
C2I05_03995	COG0850	regulation of cytokinetic process
C2I05_04000	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2I05_04010	COG1077	Cell shape determining protein MreB Mrl
C2I05_04015	COG2003	Belongs to the UPF0758 family
C2I05_04020	COG0424	maF-like protein
C2I05_04030	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C2I05_04035	COG0285	dihydrofolate synthase activity
C2I05_04040	COG0525	valine-tRNA ligase activity
C2I05_04050	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2I05_04055	COG1388	LysM domain
C2I05_04060	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2I05_04065	COG0113	porphobilinogen synthase activity
C2I05_04070	COG1587	Uroporphyrinogen-III synthase
C2I05_04075	COG0181	hydroxymethylbilane synthase activity
C2I05_04080	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2I05_04085	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C2I05_04095	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C2I05_04100	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2I05_04105	COG1067	ATP-dependent peptidase activity
C2I05_04105	COG0470	DNA polymerase III
C2I05_04110	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C2I05_04115	COG0544	peptidyl-prolyl cis-trans isomerase activity
C2I05_04120	COG0457	Tetratricopeptide repeat
C2I05_04120	COG1477	protein flavinylation
C2I05_04125	COG0066	3-isopropylmalate dehydratase activity
C2I05_04130	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2I05_04135	COG0473	3-isopropylmalate dehydrogenase activity
C2I05_04140	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2I05_04145	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C2I05_04150	COG0440	acetolactate synthase activity
C2I05_04155	COG0028	Belongs to the TPP enzyme family
C2I05_04165	COG0454	-acetyltransferase
C2I05_04175	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
C2I05_04185	COG0622	Phosphoesterase
C2I05_04190	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C2I05_04195	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C2I05_04200	COG5401	PFAM Sporulation and spore germination
C2I05_04205	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2I05_04210	COG1846	Transcriptional regulator
C2I05_04215	COG2197	response regulator
C2I05_04220	COG0824	Thioesterase
C2I05_04225	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2I05_04230	COG1053	succinate dehydrogenase
C2I05_04235	COG2009	succinate dehydrogenase
C2I05_04240	COG1719	4-vinyl reductase, 4VR
C2I05_04245	COG0527	aspartate kinase activity
C2I05_04255	COG0322	excinuclease ABC activity
C2I05_04260	COG3118	belongs to the thioredoxin family
C2I05_04270	COG3534	alpha-L-arabinofuranosidase
C2I05_04275	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C2I05_04280	COG2086	electron transfer activity
C2I05_04285	COG1024	Enoyl-CoA hydratase
C2I05_04290	COG1309	transcriptional regulator
C2I05_04295	COG0318	PFAM AMP-dependent synthetase and ligase
C2I05_04300	COG3766	membrane
C2I05_04305	COG1193	negative regulation of DNA recombination
C2I05_04310	COG1796	DNA polymerase
C2I05_04310	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2I05_04315	COG1286	toxin biosynthetic process
C2I05_04320	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C2I05_04325	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2I05_04330	COG0072	phenylalanine-tRNA ligase activity
C2I05_04330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2I05_04335	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C2I05_04345	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2I05_04355	COG3835	regulator
C2I05_04360	COG0277	FAD linked oxidase domain protein
C2I05_04365	COG0247	lactate metabolic process
C2I05_04370	COG0346	lactoylglutathione lyase activity
C2I05_04380	COG1966	Carbon starvation protein
C2I05_04385	COG3534	alpha-L-arabinofuranosidase
C2I05_04390	COG0395	ABC-type sugar transport system, permease component
C2I05_04395	COG1175	transmembrane transport
C2I05_04405	COG0371	Dehydrogenase
C2I05_04410	COG0647	UMP catabolic process
C2I05_04415	COG0235	Class ii aldolase
C2I05_04420	COG1069	ribulokinase activity
C2I05_04425	COG2160	L-arabinose isomerase activity
C2I05_04430	COG3507	Belongs to the glycosyl hydrolase 43 family
C2I05_04435	COG1363	Peptidase, m42
C2I05_04445	COG3326	Membrane
C2I05_04450	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C2I05_04455	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C2I05_04460	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C2I05_04470	COG1346	cytolysis
C2I05_04475	COG1380	Effector of murein hydrolase LrgA
C2I05_04480	COG3279	Response regulator of the LytR AlgR family
C2I05_04490	COG1011	Hydrolase
C2I05_04495	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2I05_04505	COG0398	Pfam SNARE associated Golgi protein
C2I05_04510	COG1484	DNA-dependent DNA replication
C2I05_04515	COG3611	Membrane attachment protein
C2I05_04520	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C2I05_04525	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C2I05_04530	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2I05_04535	COG1733	regulation of RNA biosynthetic process
C2I05_04540	COG2814	Major facilitator Superfamily
C2I05_04545	COG0656	L-ascorbic acid biosynthetic process
C2I05_04550	COG0237	dephospho-CoA kinase activity
C2I05_04555	COG1971	Probably functions as a manganese efflux pump
C2I05_04560	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C2I05_04565	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2I05_04565	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2I05_04570	COG5002	protein histidine kinase activity
C2I05_04575	COG0745	RESPONSE REGULATOR receiver
C2I05_04580	COG0039	L-malate dehydrogenase activity
C2I05_04585	COG0538	isocitrate dehydrogenase activity
C2I05_04590	COG0372	Belongs to the citrate synthase family
C2I05_04595	COG2707	UPF0756 membrane protein
C2I05_04600	COG0628	permease
C2I05_04605	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2I05_04610	COG0469	pyruvate kinase activity
C2I05_04615	COG0205	6-phosphofructokinase activity
C2I05_04620	COG0825	malonyl-CoA metabolic process
C2I05_04625	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C2I05_04630	COG0281	malic enzyme
C2I05_04635	COG0587	DNA-directed DNA polymerase activity
C2I05_04655	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C2I05_04665	COG4109	DRTGG domain
C2I05_04670	COG0730	response to heat
C2I05_04675	COG1473	amidohydrolase
C2I05_04680	COG0196	riboflavin kinase activity
C2I05_04685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2I05_04690	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2I05_04695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2I05_04700	COG1126	abc transporter atp-binding protein
C2I05_04705	COG0765	amino acid transport
C2I05_04710	COG0765	amino acid transport
C2I05_04715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2I05_04720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2I05_04725	COG0454	-acetyltransferase
C2I05_04730	COG0583	DNA-binding transcription factor activity
C2I05_04735	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2I05_04740	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_04750	COG0165	Argininosuccinate lyase
C2I05_04755	COG0137	argininosuccinate synthase activity
C2I05_04760	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2I05_04765	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2I05_04775	COG0827	DNA restriction-modification system
C2I05_04780	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C2I05_04785	COG3874	Sporulation protein YtfJ
C2I05_04795	COG1714	RDD family
C2I05_04800	COG0616	signal peptide processing
C2I05_04805	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2I05_04810	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C2I05_04815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2I05_04825	COG0301	tRNA thio-modification
C2I05_04830	COG1104	cysteine desulfurase activity
C2I05_04835	COG1114	Component of the transport system for branched-chain amino acids
C2I05_04840	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C2I05_04845	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2I05_04850	COG1309	transcriptional regulator
C2I05_04855	COG1956	GAF domain-containing protein
C2I05_04860	COG2203	Gaf domain
C2I05_04860	COG2199	diguanylate cyclase activity
C2I05_04870	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C2I05_04875	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2I05_04885	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2I05_04890	COG0454	-acetyltransferase
C2I05_04895	COG0517	IMP dehydrogenase activity
C2I05_04900	COG0123	including yeast histone deacetylase and acetoin utilization protein
C2I05_04905	COG1360	Flagellar Motor Protein
C2I05_04910	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2I05_04915	COG1609	Transcriptional regulator
C2I05_04920	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C2I05_04920	COG1605	Chorismate mutase
C2I05_04925	COG3118	belongs to the thioredoxin family
C2I05_04930	COG4980	gas vesicle protein
C2I05_04935	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
C2I05_04940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2I05_04945	COG1674	ftsk spoiiie
C2I05_04950	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2I05_04955	COG4848	Belongs to the UPF0354 family
C2I05_04960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2I05_04970	COG1363	Peptidase, m42
C2I05_04975	COG5584	Small secreted protein
C2I05_04980	COG0281	malic enzyme
C2I05_04985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I05_04990	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2I05_05000	COG0510	thiamine kinase activity
C2I05_05005	COG1523	belongs to the glycosyl hydrolase 13 family
C2I05_05010	COG1597	lipid kinase activity
C2I05_05020	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2I05_05025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2I05_05030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2I05_05035	COG2252	PERMEase
C2I05_05040	COG4473	ABC transporter
C2I05_05045	COG1131	(ABC) transporter
C2I05_05050	COG1349	DNA-binding transcription factor activity
C2I05_05055	COG1187	pseudouridine synthase activity
C2I05_05060	COG2244	polysaccharide biosynthetic process
C2I05_05065	COG2081	HI0933 family
C2I05_05070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2I05_05080	COG5578	integral membrane protein
C2I05_05085	COG0673	inositol 2-dehydrogenase activity
C2I05_05090	COG1653	transport
C2I05_05100	COG4209	transmembrane transport
C2I05_05105	COG2207	Transcriptional regulator
C2I05_05110	COG1653	transport
C2I05_05115	COG0395	ABC-type sugar transport system, permease component
C2I05_05120	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2I05_05125	COG2124	cytochrome p450
C2I05_05130	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2I05_05140	COG0156	8-amino-7-oxononanoate synthase activity
C2I05_05145	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2I05_05155	COG1073	alpha beta
C2I05_05160	COG1609	Transcriptional regulator
C2I05_05165	COG1653	transport
C2I05_05170	COG1175	transmembrane transport
C2I05_05175	COG0395	ABC-type sugar transport system, permease component
C2I05_05180	COG1486	melibiose metabolic process
C2I05_05185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2I05_05190	COG0495	leucyl-tRNA aminoacylation
C2I05_05200	COG2202	Pas domain
C2I05_05200	COG1366	Belongs to the anti-sigma-factor antagonist family
C2I05_05210	COG2814	Major facilitator Superfamily
C2I05_05215	COG2433	Pfam Transposase IS66
C2I05_05220	COG0577	efflux transmembrane transporter activity
C2I05_05225	COG1136	(ABC) transporter
C2I05_05230	COG2205	protein histidine kinase activity
C2I05_05235	COG0745	RESPONSE REGULATOR receiver
C2I05_05240	COG0577	efflux transmembrane transporter activity
C2I05_05245	COG1136	(ABC) transporter
C2I05_05260	COG1131	(ABC) transporter
C2I05_05265	COG1725	Transcriptional regulator
C2I05_05275	COG1242	4 iron, 4 sulfur cluster binding
C2I05_05280	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C2I05_05290	COG2267	carboxylic ester hydrolase activity
C2I05_05295	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2I05_05300	COG1113	amino acid transport
C2I05_05305	COG0367	asparagine synthase
C2I05_05310	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C2I05_05315	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C2I05_05325	COG1506	peptidase
C2I05_05330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2I05_05335	COG1116	anion transmembrane transporter activity
C2I05_05340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2I05_05345	COG0494	nUDIX hydrolase
C2I05_05350	COG4824	toxin secretion phage lysis holin
C2I05_05355	COG0783	Belongs to the Dps family
C2I05_05370	COG1854	S-ribosylhomocysteine lyase activity
C2I05_05375	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2I05_05380	COG0288	reversible hydration of carbon dioxide
C2I05_05385	COG0254	rRNA binding
C2I05_05390	COG1271	oxidase subunit
C2I05_05395	COG1294	oxidase, subunit
C2I05_05405	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2I05_05410	COG1321	iron dependent repressor
C2I05_05410	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2I05_05415	COG1121	(ABC) transporter
C2I05_05420	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2I05_05425	COG4948	Mandelate Racemase Muconate Lactonizing
C2I05_05430	COG0318	PFAM AMP-dependent synthetase and ligase
C2I05_05435	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C2I05_05440	COG0596	Alpha beta hydrolase
C2I05_05445	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C2I05_05450	COG1169	isochorismate synthase
C2I05_05455	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2I05_05465	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C2I05_05470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2I05_05475	COG0438	transferase activity, transferring glycosyl groups
C2I05_05485	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2I05_05490	COG0438	transferase activity, transferring glycosyl groups
C2I05_05495	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2I05_05500	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C2I05_05505	COG0058	SHG alpha-glucan phosphorylase activity
C2I05_05510	COG0297	glycogen (starch) synthase activity
C2I05_05515	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2I05_05520	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2I05_05525	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C2I05_05650	COG3859	Proton-coupled thiamine transporter YuaJ
C2I05_05655	COG1247	-acetyltransferase
C2I05_05660	COG2268	Band 7 protein
C2I05_05665	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2I05_05670	COG2318	DinB family
C2I05_05680	COG1454	alcohol dehydrogenase
C2I05_05685	COG1012	belongs to the aldehyde dehydrogenase family
C2I05_05690	COG1510	regulation of RNA biosynthetic process
C2I05_05700	COG0569	domain protein
C2I05_05705	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2I05_05710	COG4682	membrane
C2I05_05715	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2I05_05720	COG0477	Major facilitator Superfamily
C2I05_05725	COG5553	Cysteine dioxygenase type I
C2I05_05735	COG1968	undecaprenyl-diphosphatase activity
C2I05_05740	COG0628	permease
C2I05_05745	COG0673	inositol 2-dehydrogenase activity
C2I05_05750	COG4806	L-rhamnose isomerase
C2I05_05755	COG3254	rhamnose metabolic process
C2I05_05760	COG1070	Carbohydrate kinase
C2I05_05765	COG1349	DNA-binding transcription factor activity
C2I05_05770	COG3347	Dehydrogenase
C2I05_05770	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_05780	COG0840	transmembrane signaling receptor activity
C2I05_05785	COG0840	transmembrane signaling receptor activity
C2I05_05790	COG0840	transmembrane signaling receptor activity
C2I05_05795	COG0840	transmembrane signaling receptor activity
C2I05_05810	COG0432	Pfam Uncharacterised protein family UPF0047
C2I05_05815	COG0366	Alpha amylase catalytic
C2I05_05820	COG1253	flavin adenine dinucleotide binding
C2I05_05825	COG2738	Putative neutral zinc metallopeptidase
C2I05_05840	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2I05_05855	COG0166	Belongs to the GPI family
C2I05_05860	COG1979	alcohol dehydrogenase
C2I05_05865	COG1979	alcohol dehydrogenase
C2I05_05870	COG2155	Conserved Protein
C2I05_05875	COG1098	S1 RNA binding domain
C2I05_05880	COG0436	Aminotransferase
C2I05_05885	COG1522	sequence-specific DNA binding
C2I05_05900	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2I05_05905	COG2205	protein histidine kinase activity
C2I05_05915	COG5018	Exonuclease
C2I05_05925	COG2814	Major facilitator Superfamily
C2I05_05930	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2I05_05935	COG3011	Protein conserved in bacteria
C2I05_05945	COG3290	protein histidine kinase activity
C2I05_05950	COG4565	transcriptional regulatory protein
C2I05_05955	COG1744	ABC transporter substrate-binding protein PnrA-like
C2I05_05960	COG3845	ABC transporter
C2I05_05965	COG4603	Belongs to the binding-protein-dependent transport system permease family
C2I05_05970	COG1079	Belongs to the binding-protein-dependent transport system permease family
C2I05_05975	COG3493	citrate carrier protein
C2I05_05985	COG2111	Na H antiporter
C2I05_05985	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2I05_05990	COG2111	Na H antiporter
C2I05_05995	COG1006	Multisubunit Na H antiporter MnhC subunit
C2I05_06000	COG0651	ATP synthesis coupled electron transport
C2I05_06005	COG1863	multisubunit Na H antiporter MnhE subunit
C2I05_06010	COG2212	antiporter activity
C2I05_06015	COG1320	monovalent cation:proton antiporter activity
C2I05_06020	COG2050	protein possibly involved in aromatic compounds catabolism
C2I05_06025	COG2197	response regulator
C2I05_06030	COG4585	Histidine kinase
C2I05_06040	COG0142	geranyltranstransferase activity
C2I05_06055	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C2I05_06060	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C2I05_06065	COG1335	isochorismatase
C2I05_06070	COG5506	Protein of unknown function (DUF1694)
C2I05_06085	COG0628	permease
C2I05_06100	COG1418	mRNA catabolic process
C2I05_06105	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_06115	COG1511	domain protein
C2I05_06120	COG0433	COG0433 Predicted ATPase
C2I05_06120	COG1674	ftsk spoiiie
C2I05_06125	COG4499	WXG100 protein secretion system (Wss), protein YukC
C2I05_06130	COG5417	Belongs to the EsaB family
C2I05_06135	COG4842	Belongs to the WXG100 family
C2I05_06140	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C2I05_06140	COG2508	Transcriptional regulator
C2I05_06145	COG0686	Belongs to the AlaDH PNT family
C2I05_06150	COG5634	Uncharacterized conserved protein (DUF2278)
C2I05_06155	COG3251	PFAM MbtH domain protein
C2I05_06160	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2I05_06165	COG3433	isochorismatase activity
C2I05_06165	COG1535	isochorismatase
C2I05_06170	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2I05_06175	COG1169	isochorismate synthase
C2I05_06180	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_06185	COG2819	hydrolase of the alpha beta superfamily
C2I05_06190	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2I05_06195	COG1268	BioY protein
C2I05_06200	COG2056	Na+-H+ antiporter family
C2I05_06205	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2I05_06210	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
C2I05_06215	COG3584	3D domain protein
C2I05_06230	COG1252	NADH dehydrogenase
C2I05_06235	COG0492	ferredoxin-NADP+ reductase activity
C2I05_06245	COG0516	GMP reductase activity
C2I05_06250	COG2808	Putative FMN-binding domain
C2I05_06255	COG0456	acetyltransferase
C2I05_06260	COG0316	Belongs to the HesB IscA family
C2I05_06265	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C2I05_06270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2I05_06275	COG4844	belongs to the
C2I05_06280	COG1252	NADH dehydrogenase
C2I05_06285	COG4837	Protein of unknown function (DUF1462)
C2I05_06290	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C2I05_06295	COG1506	peptidase
C2I05_06295	COG0823	Involved in the tonB-independent uptake of proteins
C2I05_06295	COG4946	Tricorn protease homolog
C2I05_06300	COG0083	homoserine kinase activity
C2I05_06305	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2I05_06310	COG0460	homoserine dehydrogenase
C2I05_06315	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2I05_06320	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2I05_06325	COG0647	UMP catabolic process
C2I05_06330	COG2445	Protein of unknown function DUF86
C2I05_06335	COG4470	Protein conserved in bacteria
C2I05_06345	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2I05_06350	COG0739	heme binding
C2I05_06360	COG3377	Domain of unknown function (DUF1805)
C2I05_06365	COG0737	Belongs to the 5'-nucleotidase family
C2I05_06370	COG0730	response to heat
C2I05_06375	COG1801	Protein of unknown function DUF72
C2I05_06385	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2I05_06390	COG2508	Transcriptional regulator
C2I05_06395	COG2233	PERMEase
C2I05_06400	COG2233	PERMEase
C2I05_06405	COG3648	Uricase
C2I05_06405	COG3195	allantoin biosynthetic process
C2I05_06410	COG2351	hydroxyisourate hydrolase activity
C2I05_06420	COG2080	2 iron, 2 sulfur cluster binding
C2I05_06425	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2I05_06430	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C2I05_06435	COG2068	MobA-Related Protein
C2I05_06440	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C2I05_06445	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2I05_06450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2I05_06455	COG2356	endonuclease I
C2I05_06460	COG3842	ATPase activity
C2I05_06465	COG2188	Transcriptional regulator
C2I05_06470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2I05_06475	COG0395	ABC-type sugar transport system, permease component
C2I05_06480	COG1175	transmembrane transport
C2I05_06485	COG1653	transport
C2I05_06490	COG2222	sugar isomerase
C2I05_06495	COG0322	excinuclease ABC activity
C2I05_06515	COG0346	lactoylglutathione lyase activity
C2I05_06520	COG0640	Transcriptional regulator
C2I05_06525	COG0719	Fe-S assembly protein
C2I05_06530	COG0822	iron-sulfur transferase activity
C2I05_06535	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2I05_06540	COG0719	Fe-S assembly protein
C2I05_06545	COG0396	ATPase activity
C2I05_06560	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2I05_06565	COG1464	Belongs to the NlpA lipoprotein family
C2I05_06570	COG2011	ABC-type metal ion transport system permease component
C2I05_06575	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2I05_06585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2I05_06590	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C2I05_06600	COG0509	glycine decarboxylation via glycine cleavage system
C2I05_06605	COG1393	Belongs to the ArsC family
C2I05_06610	COG1960	acyl-CoA dehydrogenase activity
C2I05_06615	COG0183	Belongs to the thiolase family
C2I05_06620	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2I05_06620	COG1024	Enoyl-CoA hydratase
C2I05_06630	COG0506	proline dehydrogenase activity
C2I05_06640	COG5577	PFAM Coat F domain
C2I05_06645	COG1846	Transcriptional regulator
C2I05_06650	COG0477	Major facilitator Superfamily
C2I05_06655	COG1942	4-Oxalocrotonate Tautomerase
C2I05_06660	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_06665	COG0583	DNA-binding transcription factor activity
C2I05_06675	COG1120	ATPase activity
C2I05_06690	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_06695	COG0783	Belongs to the Dps family
C2I05_06700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2I05_06705	COG0745	RESPONSE REGULATOR receiver
C2I05_06710	COG2770	Histidine kinase
C2I05_06710	COG2205	protein histidine kinase activity
C2I05_06720	COG1309	transcriptional regulator
C2I05_06725	COG0114	fumarate hydratase activity
C2I05_06735	COG0697	spore germination
C2I05_06740	COG0814	amino acid
C2I05_06750	COG2197	response regulator
C2I05_06755	COG4585	Histidine kinase
C2I05_06760	COG4758	membrane
C2I05_06765	COG3595	metallopeptidase activity
C2I05_06770	COG1842	Phage shock protein A
C2I05_06775	COG4758	membrane
C2I05_06780	COG2814	Major facilitator Superfamily
C2I05_06785	COG2096	Adenosyltransferase
C2I05_06790	COG1120	ATPase activity
C2I05_06795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I05_06800	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I05_06805	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_06810	COG3386	PFAM SMP-30 Gluconolaconase
C2I05_06815	COG2205	protein histidine kinase activity
C2I05_06820	COG0745	RESPONSE REGULATOR receiver
C2I05_06830	COG1191	sigma factor activity
C2I05_06840	COG2140	Oxalate decarboxylase
C2I05_06850	COG0577	efflux transmembrane transporter activity
C2I05_06855	COG1136	(ABC) transporter
C2I05_06860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2I05_06865	COG1120	ATPase activity
C2I05_06870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I05_06875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I05_06880	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I05_06890	COG0531	amino acid
C2I05_06905	COG1988	membrane-bound metal-dependent
C2I05_06910	COG1368	sulfuric ester hydrolase activity
C2I05_06915	COG1910	domain protein
C2I05_06920	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2I05_06925	COG4149	molybdate abc transporter
C2I05_06930	COG0656	L-ascorbic acid biosynthetic process
C2I05_06940	COG0025	NhaP-type Na H and K H
C2I05_06945	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2I05_06950	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2I05_06955	COG3973	AAA domain
C2I05_06965	COG2860	membrane
C2I05_06970	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C2I05_06975	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2I05_06980	COG2217	Heavy metal translocating P-type atpase
C2I05_06985	COG2217	Heavy metal translocating P-type atpase
C2I05_06990	COG2608	mercury ion transmembrane transporter activity
C2I05_06995	COG1937	Protein conserved in bacteria
C2I05_07000	COG0673	inositol 2-dehydrogenase activity
C2I05_07005	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2I05_07010	COG1289	transmembrane transporter activity
C2I05_07020	COG2076	Multidrug Resistance protein
C2I05_07025	COG1309	transcriptional regulator
C2I05_07030	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_07040	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C2I05_07045	COG0557	exoribonuclease II activity
C2I05_07050	COG1647	Serine aminopeptidase, S33
C2I05_07055	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2I05_07060	COG0596	Alpha beta hydrolase
C2I05_07065	COG1476	TRANSCRIPTIONal
C2I05_07070	COG1396	sequence-specific DNA binding
C2I05_07075	COG1396	sequence-specific DNA binding
C2I05_07080	COG1733	regulation of RNA biosynthetic process
C2I05_07085	COG0840	transmembrane signaling receptor activity
C2I05_07090	COG1174	glycine betaine transport
C2I05_07095	COG1732	Glycine betaine
C2I05_07100	COG1174	glycine betaine transport
C2I05_07105	COG1125	glycine betaine transport
C2I05_07105	COG0517	IMP dehydrogenase activity
C2I05_07110	COG1510	regulation of RNA biosynthetic process
C2I05_07115	COG1174	glycine betaine transport
C2I05_07120	COG1732	Glycine betaine
C2I05_07125	COG1174	glycine betaine transport
C2I05_07130	COG0517	IMP dehydrogenase activity
C2I05_07130	COG1125	glycine betaine transport
C2I05_07135	COG1510	regulation of RNA biosynthetic process
C2I05_07140	COG2095	MarC family integral membrane protein
C2I05_07150	COG3064	Membrane
C2I05_07155	COG4640	response to antibiotic
C2I05_07160	COG0456	acetyltransferase
C2I05_07165	COG0148	phosphopyruvate hydratase activity
C2I05_07170	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C2I05_07175	COG0149	triose-phosphate isomerase activity
C2I05_07180	COG0126	phosphoglycerate kinase activity
C2I05_07185	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2I05_07190	COG2390	Transcriptional regulator
C2I05_07195	COG2814	Major facilitator Superfamily
C2I05_07200	COG1609	Transcriptional regulator
C2I05_07205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2I05_07215	COG0583	DNA-binding transcription factor activity
C2I05_07220	COG0697	spore germination
C2I05_07225	COG1113	amino acid transport
C2I05_07230	COG3858	chitin binding
C2I05_07235	COG1556	Lactate utilization protein
C2I05_07240	COG1139	Iron-sulfur cluster binding protein
C2I05_07245	COG0247	lactate metabolic process
C2I05_07260	COG2197	response regulator
C2I05_07265	COG4585	Histidine kinase
C2I05_07270	COG0842	Transport permease protein
C2I05_07275	COG1131	(ABC) transporter
C2I05_07280	COG0596	Alpha beta hydrolase
C2I05_07285	COG2208	phosphoserine phosphatase activity
C2I05_07290	COG3867	Arabinogalactan endo-beta-1,4-galactanase
C2I05_07295	COG1874	Beta-galactosidase
C2I05_07300	COG3833	ABC-type maltose transport systems, permease component
C2I05_07305	COG1175	transmembrane transport
C2I05_07310	COG2182	Extracellular solute-binding protein
C2I05_07315	COG1609	Transcriptional regulator
C2I05_07320	COG2186	Transcriptional regulator
C2I05_07325	COG1620	l-lactate permease
C2I05_07330	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2I05_07340	COG5039	Polysaccharide pyruvyl transferase
C2I05_07345	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2I05_07350	COG0110	maltose O-acetyltransferase activity
C2I05_07355	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2I05_07360	COG2244	polysaccharide biosynthetic process
C2I05_07365	COG1216	Glycosyl transferase, family 2
C2I05_07370	COG5039	Polysaccharide pyruvyl transferase
C2I05_07375	COG1216	Glycosyl transferase, family 2
C2I05_07385	COG0438	transferase activity, transferring glycosyl groups
C2I05_07390	COG1215	transferase activity, transferring glycosyl groups
C2I05_07395	COG0438	transferase activity, transferring glycosyl groups
C2I05_07400	COG1086	Polysaccharide biosynthesis protein
C2I05_07405	COG0489	protein tyrosine kinase activity
C2I05_07410	COG3944	biosynthesis protein
C2I05_07415	COG1396	sequence-specific DNA binding
C2I05_07420	COG2272	Belongs to the type-B carboxylesterase lipase family
C2I05_07430	COG3479	Phenolic acid decarboxylase
C2I05_07440	COG1794	racemase activity, acting on amino acids and derivatives
C2I05_07445	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2I05_07450	COG1621	beta-fructofuranosidase activity
C2I05_07455	COG1621	beta-fructofuranosidase activity
C2I05_07460	COG0531	amino acid
C2I05_07465	COG1309	transcriptional regulator
C2I05_07470	COG2076	Multidrug Resistance protein
C2I05_07475	COG2076	Multidrug Resistance protein
C2I05_07490	COG0740	serine-type endopeptidase activity
C2I05_07495	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2I05_07500	COG0366	Alpha amylase catalytic
C2I05_07505	COG1554	hydrolase, family 65, central catalytic
C2I05_07510	COG5521	maltodextrose utilization protein MalA
C2I05_07515	COG3833	ABC-type maltose transport systems, permease component
C2I05_07520	COG1175	transmembrane transport
C2I05_07525	COG2182	Extracellular solute-binding protein
C2I05_07530	COG0366	Alpha amylase catalytic
C2I05_07535	COG1609	Transcriptional regulator
C2I05_07540	COG1611	Belongs to the LOG family
C2I05_07545	COG1694	Mazg nucleotide pyrophosphohydrolase
C2I05_07550	COG0659	secondary active sulfate transmembrane transporter activity
C2I05_07555	COG0288	reversible hydration of carbon dioxide
C2I05_07560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2I05_07565	COG0577	efflux transmembrane transporter activity
C2I05_07570	COG1136	(ABC) transporter
C2I05_07575	COG5002	protein histidine kinase activity
C2I05_07580	COG0745	RESPONSE REGULATOR receiver
C2I05_07590	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C2I05_07595	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I05_07600	COG1481	regulation of sporulation
C2I05_07605	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C2I05_07610	COG1660	Displays ATPase and GTPase activities
C2I05_07615	COG1051	belongs to the nudix hydrolase family
C2I05_07620	COG0492	ferredoxin-NADP+ reductase activity
C2I05_07625	COG3883	PFAM NLP P60 protein
C2I05_07625	COG0791	NLP P60 protein
C2I05_07630	COG0457	Tetratricopeptide repeat
C2I05_07635	COG1132	(ABC) transporter
C2I05_07655	COG0140	phosphoribosyl-ATP diphosphatase activity
C2I05_07655	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2I05_07660	COG0107	imidazoleglycerol-phosphate synthase activity
C2I05_07665	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C2I05_07670	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2I05_07675	COG0131	Imidazoleglycerol-phosphate dehydratase
C2I05_07680	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C2I05_07685	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C2I05_07690	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C2I05_07695	COG4990	cell redox homeostasis
C2I05_07700	COG5297	Belongs to the glycosyl hydrolase family 6
C2I05_07705	COG0110	maltose O-acetyltransferase activity
C2I05_07710	COG0546	phosphoglycolate phosphatase activity
C2I05_07715	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C2I05_07720	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C2I05_07725	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C2I05_07730	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2I05_07735	COG0363	glucosamine-6-phosphate deaminase activity
C2I05_07740	COG2188	Transcriptional regulator
C2I05_07745	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2I05_07750	COG1846	Transcriptional regulator
C2I05_07755	COG2124	cytochrome p450
C2I05_07765	COG1846	Transcriptional regulator
C2I05_07770	COG2814	Major facilitator Superfamily
C2I05_07775	COG1950	PFAM Membrane protein of
C2I05_07780	COG1983	PspC domain protein
C2I05_07785	COG3595	metallopeptidase activity
C2I05_07800	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2I05_07805	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2I05_07810	COG0556	nucleotide-excision repair
C2I05_07815	COG4897	Protein conserved in bacteria
C2I05_07820	COG0574	Belongs to the PEP-utilizing enzyme family
C2I05_07820	COG3848	Pyruvate phosphate dikinase
C2I05_07825	COG1309	transcriptional regulator
C2I05_07830	COG2814	Major facilitator Superfamily
C2I05_07835	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2I05_07845	COG3409	Peptidoglycan-binding domain 1 protein
C2I05_07845	COG0793	Belongs to the peptidase S41A family
C2I05_07850	COG2177	Part of the ABC transporter FtsEX involved in
C2I05_07855	COG2884	Cell division ATP-binding protein ftsE
C2I05_07860	COG2010	Cytochrome c
C2I05_07865	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I05_07875	COG0653	protein targeting
C2I05_07880	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2I05_07895	COG1516	flagellar protein fliS
C2I05_07900	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C2I05_07905	COG1334	flagellar protein FlaG
C2I05_07910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2I05_07915	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C2I05_07920	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
C2I05_07930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2I05_07935	COG4786	Flagellar basal body rod
C2I05_07935	COG1256	bacterial-type flagellum assembly
C2I05_07940	COG3418	PFAM FlgN family protein
C2I05_07945	COG2747	anti-sigma28 factor FlgM
C2I05_07955	COG1040	competence protein
C2I05_07965	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C2I05_07970	COG1307	EDD domain protein, DegV family
C2I05_07975	COG2197	response regulator
C2I05_07980	COG4585	Histidine kinase
C2I05_07985	COG1739	Uncharacterized protein family UPF0029
C2I05_07990	COG1316	TRANSCRIPTIONal
C2I05_07995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2I05_08000	COG0438	transferase activity, transferring glycosyl groups
C2I05_08005	COG1215	transferase activity, transferring glycosyl groups
C2I05_08010	COG3206	protein involved in exopolysaccharide biosynthesis
C2I05_08015	COG3307	-O-antigen
C2I05_08020	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C2I05_08025	COG0438	transferase activity, transferring glycosyl groups
C2I05_08025	COG0297	glycogen (starch) synthase activity
C2I05_08030	COG2244	polysaccharide biosynthetic process
C2I05_08045	COG2247	cell wall binding repeat
C2I05_08045	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2I05_08050	COG2247	cell wall binding repeat
C2I05_08050	COG2385	sporulation resulting in formation of a cellular spore
C2I05_08060	COG1316	TRANSCRIPTIONal
C2I05_08065	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2I05_08085	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2I05_08090	COG1134	teichoic acid transport
C2I05_08095	COG1682	transport, permease protein
C2I05_08100	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C2I05_08105	COG1442	glycosyl transferase family 8
C2I05_08105	COG1216	Glycosyl transferase, family 2
C2I05_08145	COG4193	domain, Protein
C2I05_08150	COG1482	cell wall glycoprotein biosynthetic process
C2I05_08155	COG0697	spore germination
C2I05_08160	COG0814	amino acid
C2I05_08170	COG2814	Major facilitator Superfamily
C2I05_08175	COG1316	TRANSCRIPTIONal
C2I05_08180	COG0561	phosphatase activity
C2I05_08185	COG0791	NLP P60 protein
C2I05_08195	COG2843	Capsule synthesis protein
C2I05_08205	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2I05_08215	COG1609	Transcriptional regulator
C2I05_08220	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2I05_08225	COG1869	D-ribose catabolic process
C2I05_08230	COG1129	ABC transporter
C2I05_08235	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2I05_08240	COG1879	ABC-type sugar transport system periplasmic component
C2I05_08245	COG3103	Sh3 type 3 domain protein
C2I05_08255	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2I05_08260	COG3527	Alpha-acetolactate decarboxylase
C2I05_08265	COG0028	Belongs to the TPP enzyme family
C2I05_08270	COG0583	DNA-binding transcription factor activity
C2I05_08275	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2I05_08290	COG5337	Spore coat protein CotH
C2I05_08300	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2I05_08310	COG0405	Gamma-glutamyltransferase
C2I05_08315	COG1522	sequence-specific DNA binding
C2I05_08320	COG2059	Chromate
C2I05_08325	COG2059	Chromate
C2I05_08340	COG5444	nuclease activity
C2I05_08355	COG3878	Protein conserved in bacteria
C2I05_08360	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C2I05_08365	COG4464	protein tyrosine phosphatase activity
C2I05_08370	COG0489	protein tyrosine kinase activity
C2I05_08375	COG3944	biosynthesis protein
C2I05_08385	COG4715	Zinc finger, swim domain protein
C2I05_08390	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2I05_08400	COG0561	phosphatase activity
C2I05_08405	COG1349	DNA-binding transcription factor activity
C2I05_08410	COG0629	single-stranded DNA binding
C2I05_08425	COG3764	Sortase (surface protein transpeptidase)
C2I05_08435	COG3279	Response regulator of the LytR AlgR family
C2I05_08440	COG0745	RESPONSE REGULATOR receiver
C2I05_08440	COG2972	Histidine kinase
C2I05_08445	COG1970	mechanosensitive ion channel activity
C2I05_08450	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2I05_08455	COG0457	Tetratricopeptide repeat
C2I05_08460	COG4786	Flagellar basal body rod
C2I05_08465	COG4786	Flagellar basal body rod
C2I05_08470	COG1077	Cell shape determining protein MreB Mrl
C2I05_08475	COG1609	Transcriptional regulator
C2I05_08485	COG1846	Transcriptional regulator
C2I05_08490	COG2814	Major facilitator Superfamily
C2I05_08500	COG3420	alginic acid biosynthetic process
C2I05_08505	COG1953	Uracil, thiamine, allantoin
C2I05_08510	COG0477	Major facilitator Superfamily
C2I05_08515	COG1335	isochorismatase
C2I05_08525	COG0004	ammonium transporteR
C2I05_08530	COG0347	Belongs to the P(II) protein family
C2I05_08535	COG0671	phosphoesterase, PA-phosphatase related
C2I05_08545	COG0739	heme binding
C2I05_08550	COG1247	-acetyltransferase
C2I05_08565	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2I05_08570	COG0789	Transcriptional regulator
C2I05_08580	COG2910	NAD(P)H-binding
C2I05_08585	COG1959	2 iron, 2 sulfur cluster binding
C2I05_08590	COG0804	urea catabolic process
C2I05_08595	COG0832	Belongs to the urease beta subunit family
C2I05_08600	COG0831	urea catabolic process
C2I05_08615	COG3237	CsbD-like
C2I05_08620	COG1994	Peptidase M50
C2I05_08625	COG0457	Tetratricopeptide repeat
C2I05_08630	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2I05_08635	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2I05_08645	COG2304	oxidoreductase activity
C2I05_08655	COG2304	oxidoreductase activity
C2I05_08660	COG2385	sporulation resulting in formation of a cellular spore
C2I05_08665	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2I05_08675	COG4836	Membrane
C2I05_08685	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C2I05_08690	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C2I05_08695	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C2I05_08700	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C2I05_08705	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2I05_08710	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C2I05_08720	COG0356	it plays a direct role in the translocation of protons across the membrane
C2I05_08730	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C2I05_08735	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2I05_08740	COG4475	Protein of unknown function (DUF436)
C2I05_08745	COG0698	ribose 5-phosphate isomerase
C2I05_08750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2I05_08755	COG1971	Probably functions as a manganese efflux pump
C2I05_08760	COG0009	L-threonylcarbamoyladenylate synthase
C2I05_08765	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2I05_08785	COG2890	protein-(glutamine-N5) methyltransferase activity
C2I05_08790	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C2I05_08795	COG0346	lactoylglutathione lyase activity
C2I05_08800	COG0789	Transcriptional regulator
C2I05_08805	COG0679	Auxin Efflux Carrier
C2I05_08810	COG0281	malic enzyme
C2I05_08815	COG1435	thymidine kinase activity
C2I05_08825	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2I05_08830	COG1494	fructose-1,6-bisphosphatase
C2I05_08835	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2I05_08840	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2I05_08845	COG0191	fructose-bisphosphate aldolase activity
C2I05_08850	COG2204	response regulator
C2I05_08855	COG4821	SIS domain
C2I05_08860	COG0504	CTP synthase activity
C2I05_08865	COG3343	RNA polymerase activity
C2I05_08870	COG1960	acyl-CoA dehydrogenase activity
C2I05_08875	COG2181	nitrate reductase activity
C2I05_08875	COG0247	lactate metabolic process
C2I05_08880	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2I05_08885	COG4294	response to UV
C2I05_08895	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2I05_08900	COG1132	(ABC) transporter
C2I05_08905	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2I05_08915	COG2181	nitrate reductase activity
C2I05_08920	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2I05_08925	COG1140	nitrate reductase beta subunit
C2I05_08930	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2I05_08940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2I05_08950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2I05_08955	COG2223	nitrite transmembrane transporter activity
C2I05_08960	COG0018	arginyl-trna synthetase
C2I05_08965	COG4506	Protein conserved in bacteria
C2I05_08980	COG0535	radical SAM domain protein
C2I05_08990	COG1131	(ABC) transporter
C2I05_08995	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C2I05_09000	COG0612	Peptidase, M16
C2I05_09005	COG0612	Peptidase, M16
C2I05_09015	COG3391	amine dehydrogenase activity
C2I05_09020	COG3391	amine dehydrogenase activity
C2I05_09030	COG0457	Tetratricopeptide repeat
C2I05_09060	COG1131	(ABC) transporter
C2I05_09070	COG0010	Belongs to the arginase family
C2I05_09075	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C2I05_09080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2I05_09095	COG1994	Peptidase M50
C2I05_09100	COG1942	4-Oxalocrotonate Tautomerase
C2I05_09105	COG1846	Transcriptional regulator
C2I05_09110	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2I05_09115	COG0477	Major facilitator Superfamily
C2I05_09120	COG1959	2 iron, 2 sulfur cluster binding
C2I05_09125	COG3465	dGTPase activity
C2I05_09130	COG1078	dGTPase activity
C2I05_09135	COG4844	belongs to the
C2I05_09145	COG0697	spore germination
C2I05_09150	COG0095	Lipoate-protein ligase
C2I05_09155	COG0583	DNA-binding transcription factor activity
C2I05_09160	COG0280	phosphate acetyltransferase
C2I05_09165	COG3253	May function as heme-dependent peroxidase
C2I05_09170	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_09175	COG0436	Aminotransferase
C2I05_09180	COG2814	Major facilitator Superfamily
C2I05_09185	COG0151	Belongs to the GarS family
C2I05_09190	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_09195	COG1917	Cupin 2, conserved barrel domain protein
C2I05_09200	COG0077	Prephenate dehydratase
C2I05_09205	COG2814	Major facilitator Superfamily
C2I05_09210	COG0833	amino acid
C2I05_09215	COG4187	Peptidase family M20/M25/M40
C2I05_09220	COG1012	belongs to the aldehyde dehydrogenase family
C2I05_09225	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2I05_09235	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C2I05_09240	COG1091	dTDP-4-dehydrorhamnose reductase activity
C2I05_09245	COG1088	dTDP-glucose 4,6-dehydratase activity
C2I05_09250	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C2I05_09255	COG3980	spore coat polysaccharide biosynthesis protein
C2I05_09260	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
C2I05_09265	COG2089	acid synthase
C2I05_09270	COG0456	acetyltransferase
C2I05_09275	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2I05_09280	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C2I05_09285	COG0463	Glycosyl transferase, family 2
C2I05_09300	COG2363	Small membrane protein
C2I05_09305	COG2233	PERMEase
C2I05_09315	COG1012	belongs to the aldehyde dehydrogenase family
C2I05_09320	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C2I05_09325	COG1216	Glycosyl transferase, family 2
C2I05_09330	COG0351	phosphomethylpyrimidine kinase
C2I05_09340	COG1621	beta-fructofuranosidase activity
C2I05_09345	COG1263	PTS System
C2I05_09345	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I05_09350	COG2116	formate transmembrane transporter activity
C2I05_09355	COG3711	transcriptional antiterminator
C2I05_09365	COG1404	Belongs to the peptidase S8 family
C2I05_09370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2I05_09375	COG0778	Nitroreductase
C2I05_09380	COG0772	Belongs to the SEDS family
C2I05_09390	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2I05_09395	COG1845	cytochrome c oxidase, subunit III
C2I05_09400	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2I05_09410	COG2261	transglycosylase associated protein
C2I05_09415	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C2I05_09420	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C2I05_09425	COG2246	polysaccharide biosynthetic process
C2I05_09430	COG1309	transcriptional regulator
C2I05_09440	COG3162	membrane
C2I05_09445	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2I05_09450	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C2I05_09455	COG2837	iron assimilation
C2I05_09460	COG2822	iron ion transport
C2I05_09465	COG0672	)-iron permease
C2I05_09470	COG0352	thiamine-phosphate diphosphorylase activity
C2I05_09475	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C2I05_09480	COG0583	DNA-binding transcription factor activity
C2I05_09485	COG1380	Effector of murein hydrolase LrgA
C2I05_09490	COG1346	cytolysis
C2I05_09495	COG2814	Major facilitator Superfamily
C2I05_09500	COG4895	conserved protein (DUF2196)
C2I05_09505	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2I05_09510	COG0346	lactoylglutathione lyase activity
C2I05_09520	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2I05_09525	COG1404	Belongs to the peptidase S8 family
C2I05_09530	COG1263	PTS System
C2I05_09530	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I05_09535	COG3711	transcriptional antiterminator
C2I05_09540	COG1442	glycosyl transferase family 8
C2I05_09545	COG5522	Integral membrane protein (intg_mem_TP0381)
C2I05_09550	COG1846	Transcriptional regulator
C2I05_09555	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2I05_09560	COG2234	aminopeptidase activity
C2I05_09565	COG2357	RelA SpoT domain protein
C2I05_09570	COG1575	Belongs to the MenA family. Type 1 subfamily
C2I05_09585	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2I05_09590	COG1696	Membrane protein involved in D-alanine export
C2I05_09595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2I05_09600	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C2I05_09605	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
C2I05_09610	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2I05_09615	COG1486	melibiose metabolic process
C2I05_09620	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2I05_09625	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2I05_09630	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2I05_09635	COG3711	transcriptional antiterminator
C2I05_09635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I05_09645	COG2094	Belongs to the DNA glycosylase MPG family
C2I05_09650	COG0753	catalase activity
C2I05_09655	COG2814	Major facilitator Superfamily
C2I05_09660	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2I05_09685	COG1595	DNA-templated transcription, initiation
C2I05_09690	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2I05_09695	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2I05_09700	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2I05_09705	COG4988	ABC transporter
C2I05_09710	COG1294	oxidase, subunit
C2I05_09715	COG1271	oxidase subunit
C2I05_09720	COG3493	citrate carrier protein
C2I05_09725	COG0501	Belongs to the peptidase M48B family
C2I05_09735	COG0726	polysaccharide deacetylase
C2I05_09740	COG3842	ATPase activity
C2I05_09745	COG2508	Transcriptional regulator
C2I05_09750	COG1012	belongs to the aldehyde dehydrogenase family
C2I05_09755	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I05_09765	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2I05_09775	COG4585	Histidine kinase
C2I05_09780	COG2197	response regulator
C2I05_09785	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2I05_09795	COG4894	glucomannan catabolic process
C2I05_09800	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2I05_09805	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2I05_09810	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_09815	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2I05_09820	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2I05_09830	COG0500	methyltransferase
C2I05_09835	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2I05_09850	COG0693	protein deglycase activity
C2I05_09850	COG0753	catalase activity
C2I05_09860	COG2273	Hydrolase Family 16
C2I05_09865	COG3711	transcriptional antiterminator
C2I05_09875	COG2270	Major facilitator Superfamily
C2I05_09880	COG0513	Belongs to the DEAD box helicase family
C2I05_09885	COG3401	FG-GAP repeat protein
C2I05_09885	COG2755	lipolytic protein G-D-S-L family
C2I05_09955	COG0697	spore germination
C2I05_09960	COG0589	response to stress
C2I05_09965	COG2723	6-phospho-beta-galactosidase activity
C2I05_09970	COG2190	(PTS) system
C2I05_09970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I05_09970	COG1263	PTS System
C2I05_10005	COG5444	nuclease activity
C2I05_10025	COG0494	nUDIX hydrolase
C2I05_10035	COG3507	Belongs to the glycosyl hydrolase 43 family
C2I05_10045	COG2986	histidine ammonia-lyase
C2I05_10050	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C2I05_10055	COG1228	amidohydrolase
C2I05_10060	COG0010	Belongs to the arginase family
C2I05_10065	COG0833	amino acid
C2I05_10070	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C2I05_10075	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2I05_10080	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C2I05_10085	COG2390	Transcriptional regulator
C2I05_10095	COG3192	ethanolamine utilization protein
C2I05_10100	COG2079	MmgE PrpD family protein
C2I05_10105	COG1473	amidohydrolase
C2I05_10110	COG1126	abc transporter atp-binding protein
C2I05_10115	COG0765	amino acid transport
C2I05_10120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2I05_10125	COG0456	acetyltransferase
C2I05_10130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2I05_10140	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C2I05_10145	COG0561	phosphatase activity
C2I05_10175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I05_10180	COG5294	Protein conserved in bacteria
C2I05_10185	COG0577	efflux transmembrane transporter activity
C2I05_10190	COG1136	(ABC) transporter
C2I05_10195	COG2205	protein histidine kinase activity
C2I05_10200	COG0745	RESPONSE REGULATOR receiver
C2I05_10205	COG0191	fructose-bisphosphate aldolase activity
C2I05_10210	COG1082	Xylose isomerase domain protein TIM barrel
C2I05_10215	COG1082	Xylose isomerase domain protein TIM barrel
C2I05_10220	COG0673	inositol 2-dehydrogenase activity
C2I05_10225	COG2814	Major facilitator Superfamily
C2I05_10230	COG1082	Xylose isomerase domain protein TIM barrel
C2I05_10235	COG3962	Belongs to the TPP enzyme family
C2I05_10240	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2I05_10250	COG1012	belongs to the aldehyde dehydrogenase family
C2I05_10255	COG1349	DNA-binding transcription factor activity
C2I05_10260	COG0667	Aldo Keto reductase
C2I05_10290	COG2814	Major facilitator Superfamily
C2I05_10295	COG0326	Molecular chaperone. Has ATPase activity
C2I05_10305	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_10310	COG1309	transcriptional regulator
C2I05_10315	COG1012	belongs to the aldehyde dehydrogenase family
C2I05_10325	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2I05_10335	COG1714	RDD family
C2I05_10340	COG2311	Membrane
C2I05_10345	COG1917	Cupin 2, conserved barrel domain protein
C2I05_10350	COG1309	transcriptional regulator
C2I05_10355	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_10360	COG1846	Transcriptional regulator
C2I05_10365	COG1380	Effector of murein hydrolase LrgA
C2I05_10370	COG1346	cytolysis
C2I05_10375	COG5039	Polysaccharide pyruvyl transferase
C2I05_10385	COG1802	Transcriptional regulator
C2I05_10390	COG1070	Carbohydrate kinase
C2I05_10395	COG2610	gluconate transmembrane transporter activity
C2I05_10400	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C2I05_10405	COG0450	alkyl hydroperoxide reductase
C2I05_10410	COG3634	alkyl hydroperoxide reductase activity
C2I05_10420	COG2723	6-phospho-beta-galactosidase activity
C2I05_10425	COG2190	(PTS) system
C2I05_10435	COG2188	Transcriptional regulator
C2I05_10450	COG1131	(ABC) transporter
C2I05_10455	COG1994	Peptidase M50
C2I05_10460	COG0535	radical SAM domain protein
C2I05_10470	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
C2I05_10480	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C2I05_10495	COG1063	alcohol dehydrogenase
C2I05_10515	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
C2I05_10520	COG0456	acetyltransferase
C2I05_10525	COG0457	Tetratricopeptide repeat
C2I05_10535	COG0010	Belongs to the arginase family
C2I05_10540	COG0833	amino acid
C2I05_10545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2I05_10550	COG3829	transcription factor binding
C2I05_10565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2I05_10570	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C2I05_10575	COG4853	Protein conserved in bacteria
C2I05_10580	COG4863	YycH protein
C2I05_10585	COG5002	protein histidine kinase activity
C2I05_10590	COG0745	RESPONSE REGULATOR receiver
C2I05_10625	COG0305	Participates in initiation and elongation during chromosome replication
C2I05_10640	COG3093	addiction module antidote protein HigA
C2I05_10645	COG2807	transmembrane transport
C2I05_10650	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2I05_10655	COG0359	binds to the 23S rRNA
C2I05_10660	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
C2I05_10665	COG4241	membrane
C2I05_10675	COG5577	PFAM Coat F domain
C2I05_10680	COG1733	regulation of RNA biosynthetic process
C2I05_10685	COG1227	inorganic diphosphatase activity
C2I05_10700	COG2271	Major facilitator Superfamily
C2I05_10715	COG4319	ketosteroid isomerase
C2I05_10725	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I05_10730	COG1846	Transcriptional regulator
C2I05_10735	COG2153	protein acetylation
C2I05_10740	COG2364	Membrane
C2I05_10745	COG0456	acetyltransferase
C2I05_10750	COG2315	Protein conserved in bacteria
C2I05_10755	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2I05_10795	COG1331	Highly conserved protein containing a thioredoxin domain
C2I05_10800	COG1266	CAAX protease self-immunity
C2I05_10805	COG0477	Major facilitator Superfamily
C2I05_10805	COG2814	Major facilitator Superfamily
C2I05_10810	COG0110	maltose O-acetyltransferase activity
C2I05_10815	COG0346	lactoylglutathione lyase activity
C2I05_10820	COG1609	Transcriptional regulator
C2I05_10825	COG0708	Exodeoxyribonuclease III
C2I05_10830	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2I05_10835	COG0629	single-stranded DNA binding
C2I05_10840	COG0360	Binds together with S18 to 16S ribosomal RNA
C2I05_10845	COG0012	GTP binding
C2I05_10850	COG0243	molybdopterin cofactor binding
C2I05_10855	COG4481	Protein conserved in bacteria
C2I05_10860	COG3949	Membrane
C2I05_10870	COG1475	DNA binding
C2I05_10875	COG1192	Involved in chromosome partitioning
C2I05_10885	COG1475	DNA binding
C2I05_10890	COG0357	Ribosomal RNA small subunit methyltransferase G
C2I05_10895	COG0445	tRNA wobble uridine modification
C2I05_10900	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C2I05_10905	COG1847	R3H domain protein
C2I05_10910	COG0706	membrane insertase activity
C2I05_10915	COG0594	ribonuclease P activity
C2I05_10925	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C2I05_10930	COG0592	DNA-directed DNA polymerase activity
C2I05_10935	COG2501	S4 domain
C2I05_10940	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2I05_10950	COG0187	DNA topoisomerase II activity
C2I05_10955	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2I05_10990	COG0516	GMP reductase activity
C2I05_10990	COG0517	IMP dehydrogenase activity
C2I05_10995	COG1686	Belongs to the peptidase S11 family
C2I05_11000	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C2I05_11005	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C2I05_11010	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C2I05_11020	COG1428	Deoxynucleoside kinase
C2I05_11025	COG1428	Deoxynucleoside kinase
C2I05_11030	COG3858	chitin binding
C2I05_11030	COG1388	LysM domain
C2I05_11035	COG1335	isochorismatase
C2I05_11040	COG0590	tRNA wobble adenosine to inosine editing
C2I05_11050	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C2I05_11055	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C2I05_11060	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C2I05_11105	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
C2I05_11110	COG3853	Toxic anion resistance protein (TelA)
C2I05_11115	COG1982	Orn Lys Arg decarboxylase major
C2I05_11120	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C2I05_11125	COG3870	Protein conserved in bacteria
C2I05_11130	COG1728	Protein conserved in bacteria
C2I05_11135	COG0470	DNA polymerase III
C2I05_11140	COG1774	PSP1 C-terminal conserved region
C2I05_11145	COG4467	Involved in initiation control of chromosome replication
C2I05_11150	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C2I05_11155	COG2827	Endonuclease containing a URI domain
C2I05_11160	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2I05_11165	COG2002	toxin-antitoxin pair type II binding
C2I05_11170	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2I05_11170	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2I05_11175	COG0084	hydrolase, TatD family'
C2I05_11180	COG3584	3D domain protein
C2I05_11180	COG3583	domain protein
C2I05_11185	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C2I05_11190	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2I05_11200	COG4466	Protein conserved in bacteria
C2I05_11210	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C2I05_11215	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2I05_11220	COG0251	oxidation-reduction process
C2I05_11225	COG2088	sporulation resulting in formation of a cellular spore
C2I05_11230	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2I05_11235	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2I05_11240	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C2I05_11245	COG0193	aminoacyl-tRNA hydrolase activity
C2I05_11255	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2I05_11260	COG2002	toxin-antitoxin pair type II binding
C2I05_11265	COG2244	polysaccharide biosynthetic process
C2I05_11270	COG3956	TIGRFAM MazG family protein
C2I05_11275	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C2I05_11290	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C2I05_11295	COG1098	S1 RNA binding domain
C2I05_11310	COG2208	phosphoserine phosphatase activity
C2I05_11315	COG2304	oxidoreductase activity
C2I05_11320	COG0515	serine threonine protein kinase
C2I05_11325	COG0037	tRNA processing
C2I05_11330	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C2I05_11335	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2I05_11340	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C2I05_11345	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C2I05_11350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2I05_11355	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2I05_11360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2I05_11365	COG0512	Glutamine amidotransferase of anthranilate synthase
C2I05_11370	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2I05_11375	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2I05_11380	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2I05_11385	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2I05_11390	COG1396	sequence-specific DNA binding
C2I05_11395	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2I05_11400	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2I05_11480	COG4463	regulation of RNA biosynthetic process
C2I05_11485	COG3880	PFAM UvrB UvrC protein
C2I05_11490	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C2I05_11495	COG0542	response to heat
C2I05_11500	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2I05_11505	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C2I05_11510	COG4956	integral membrane protein (PIN domain superfamily)
C2I05_11515	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C2I05_11520	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C2I05_11525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2I05_11535	COG1045	serine acetyltransferase
C2I05_11540	COG0215	cysteine-tRNA ligase activity
C2I05_11545	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C2I05_11550	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2I05_11555	COG3688	RNA-binding protein containing a PIN domain
C2I05_11560	COG1595	DNA-templated transcription, initiation
C2I05_11570	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2I05_11575	COG0250	Participates in transcription elongation, termination and antitermination
C2I05_11585	COG0081	regulation of translation
C2I05_11590	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C2I05_11600	COG2813	Specifically methylates the guanine in position
C2I05_11605	COG0085	RNA polymerase activity
C2I05_11610	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C2I05_11615	COG1358	cellular component organization or biogenesis
C2I05_11620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C2I05_11625	COG0049	tRNA binding
C2I05_11630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2I05_11635	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2I05_11640	COG0596	Alpha beta hydrolase
C2I05_11650	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C2I05_11655	COG0088	Forms part of the polypeptide exit tunnel
C2I05_11665	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C2I05_11685	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2I05_11695	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C2I05_11700	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C2I05_11710	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C2I05_11720	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C2I05_11725	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C2I05_11730	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C2I05_11735	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C2I05_11745	COG0200	Binds to the 23S rRNA
C2I05_11750	COG0201	protein transport
C2I05_11755	COG0563	adenylate kinase activity
C2I05_11760	COG0024	Methionine aminopeptidase
C2I05_11765	COG2163	COG2163 Ribosomal protein L14E L6E L27E
C2I05_11775	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2I05_11780	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C2I05_11785	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C2I05_11790	COG0202	RNA polymerase activity
C2I05_11795	COG0203	ribosomal protein L17
C2I05_11800	COG1122	ATPase activity
C2I05_11805	COG1122	ATPase activity
C2I05_11810	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C2I05_11815	COG0101	tRNA pseudouridine synthase activity
C2I05_11820	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2I05_11825	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C2I05_11830	COG2226	methyltransferase
C2I05_11840	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2I05_11845	COG0489	protein tyrosine kinase activity
C2I05_11855	COG2194	sulfuric ester hydrolase activity
C2I05_11860	COG0726	polysaccharide deacetylase
C2I05_11945	COG0659	secondary active sulfate transmembrane transporter activity
C2I05_11950	COG0385	Bile acid
C2I05_11955	COG2819	hydrolase of the alpha beta superfamily
C2I05_11960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I05_11965	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I05_11970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I05_11975	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I05_11975	COG2207	Transcriptional regulator
C2I05_11980	COG3876	Protein conserved in bacteria
C2I05_11985	COG1472	Belongs to the glycosyl hydrolase 3 family
C2I05_11990	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2I05_11995	COG1263	PTS System
C2I05_11995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I05_12000	COG1737	Transcriptional regulator
C2I05_12005	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C2I05_12010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I05_12015	COG1683	Conserved Protein
C2I05_12045	COG1595	DNA-templated transcription, initiation
C2I05_12050	COG5662	AntiSigma factor
C2I05_12055	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C2I05_12060	COG4856	YbbR-like protein
C2I05_12065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2I05_12070	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2I05_12080	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2I05_12085	COG2169	Transcriptional regulator
C2I05_12090	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2I05_12095	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2I05_12100	COG3002	Belongs to the UPF0753 family
C2I05_12105	COG0288	reversible hydration of carbon dioxide
C2I05_12115	COG5609	conserved protein (DUF2294)
C2I05_12120	COG0640	Transcriptional regulator
C2I05_12125	COG2814	Major facilitator Superfamily
C2I05_12140	COG0596	Alpha beta hydrolase
C2I05_12145	COG0745	RESPONSE REGULATOR receiver
C2I05_12150	COG0642	Histidine kinase
C2I05_12160	COG0515	serine threonine protein kinase
C2I05_12175	COG1113	amino acid transport
C2I05_12190	COG2602	Beta-lactamase
C2I05_12195	COG2124	cytochrome p450
C2I05_12205	COG0531	amino acid
C2I05_12210	COG0584	glycerophosphoryl diester phosphodiesterase
C2I05_12215	COG2271	Major facilitator Superfamily
C2I05_12230	COG1846	Transcriptional regulator
C2I05_12230	COG0456	acetyltransferase
C2I05_12235	COG2271	Major facilitator Superfamily
C2I05_12245	COG3409	Peptidoglycan-binding domain 1 protein
C2I05_12250	COG0697	spore germination
C2I05_12255	COG2207	Transcriptional regulator
C2I05_12255	COG1917	Cupin 2, conserved barrel domain protein
C2I05_12260	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C2I05_12265	COG3591	Belongs to the peptidase S1B family
C2I05_12275	COG0596	Alpha beta hydrolase
C2I05_12280	COG1183	phosphatidylcholine synthase activity
C2I05_12285	COG0586	Pfam SNARE associated Golgi protein
C2I05_12290	COG0688	phosphatidylethanolamine metabolic process
C2I05_12300	COG2312	Erythromycin esterase
C2I05_12305	COG1054	Belongs to the UPF0176 family
C2I05_12310	COG1301	dicarboxylic acid transport
C2I05_12315	COG1263	PTS System
C2I05_12315	COG2190	(PTS) system
C2I05_12315	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I05_12320	COG0363	glucosamine-6-phosphate deaminase activity
C2I05_12325	COG2188	Transcriptional regulator
C2I05_12335	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2I05_12340	COG0833	amino acid
C2I05_12345	COG2040	homocysteine
C2I05_12355	COG1115	amino acid carrier protein
C2I05_12360	COG2066	Belongs to the glutaminase family
C2I05_12365	COG4191	Histidine kinase
C2I05_12370	COG0784	Response regulator, receiver
C2I05_12380	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2I05_12385	COG1012	belongs to the aldehyde dehydrogenase family
C2I05_12390	COG2271	Major facilitator Superfamily
C2I05_12395	COG4948	Mandelate Racemase Muconate Lactonizing
C2I05_12400	COG2186	Transcriptional regulator
C2I05_12405	COG2721	sulfolactate sulfo-lyase activity
C2I05_12410	COG3173	Aminoglycoside phosphotransferase
C2I05_12425	COG0745	RESPONSE REGULATOR receiver
C2I05_12430	COG2205	protein histidine kinase activity
C2I05_12435	COG1131	(ABC) transporter
C2I05_12450	COG3773	Cell wall hydrolase
C2I05_12455	COG2304	oxidoreductase activity
C2I05_12465	COG3540	Alkaline phosphatase
C2I05_12470	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2I05_12475	COG0805	protein transport
C2I05_12480	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C2I05_12485	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2I05_12490	COG0477	Major facilitator Superfamily
C2I05_12495	COG1309	transcriptional regulator
C2I05_12500	COG0252	asparaginase activity
C2I05_12505	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C2I05_12510	COG1714	RDD family
C2I05_12515	COG3012	SEC-C Motif Domain Protein
C2I05_12515	COG1405	negative regulation of cell septum assembly
C2I05_12520	COG3290	protein histidine kinase activity
C2I05_12525	COG3279	Response regulator of the LytR AlgR family
C2I05_12530	COG4555	ABC transporter
C2I05_12535	COG1668	transmembrane transport
C2I05_12540	COG0667	Aldo Keto reductase
C2I05_12550	COG1595	DNA-templated transcription, initiation
C2I05_12560	COG1595	DNA-templated transcription, initiation
C2I05_12565	COG1876	peptidase activity
C2I05_12570	COG0457	Tetratricopeptide repeat
C2I05_12575	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_12580	COG0366	Alpha amylase catalytic
C2I05_12585	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2I05_12590	COG1121	(ABC) transporter
C2I05_12595	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2I05_12600	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2I05_12605	COG2310	stress, protein
C2I05_12610	COG2310	stress, protein
C2I05_12615	COG2310	stress, protein
C2I05_12620	COG0861	Integral membrane protein TerC family
C2I05_12630	COG3853	Toxic anion resistance protein (TelA)
C2I05_12635	COG0477	Major facilitator Superfamily
C2I05_12645	COG2814	Major facilitator Superfamily
C2I05_12650	COG0640	Transcriptional regulator
C2I05_12655	COG0517	IMP dehydrogenase activity
C2I05_12655	COG4175	Glycine betaine
C2I05_12660	COG4176	ABC-type proline glycine betaine transport system permease component
C2I05_12665	COG2113	Glycine betaine
C2I05_12670	COG1473	amidohydrolase
C2I05_12675	COG1288	antiporter activity
C2I05_12685	COG0366	Alpha amylase catalytic
C2I05_12690	COG0039	L-malate dehydrogenase activity
C2I05_12695	COG1620	l-lactate permease
C2I05_12700	COG2814	Major facilitator Superfamily
C2I05_12705	COG1846	Transcriptional regulator
C2I05_12710	COG1280	lysine exporter protein (LysE YggA)
C2I05_12715	COG3403	YqcI/YcgG family
C2I05_12720	COG1113	amino acid transport
C2I05_12725	COG3665	Urea carboxylase-associated protein
C2I05_12730	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C2I05_12735	COG1660	Displays ATPase and GTPase activities
C2I05_12740	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2I05_12745	COG2226	methyltransferase
C2I05_12750	COG0583	DNA-binding transcription factor activity
C2I05_12755	COG3458	cephalosporin-C deacetylase activity
C2I05_12760	COG3541	Predicted nucleotidyltransferase
C2I05_12765	COG0506	proline dehydrogenase activity
C2I05_12770	COG1012	belongs to the aldehyde dehydrogenase family
C2I05_12775	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2I05_12780	COG2508	Transcriptional regulator
C2I05_12785	COG3689	TIGRFAM TIGR03943 family protein
C2I05_12790	COG0701	Predicted permease
C2I05_12795	COG2267	carboxylic ester hydrolase activity
C2I05_12800	COG0492	ferredoxin-NADP+ reductase activity
C2I05_12805	COG1587	Uroporphyrinogen-III synthase
C2I05_12805	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2I05_12810	COG2146	nitrite reductase [NAD(P)H] activity
C2I05_12815	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2I05_12820	COG0243	molybdopterin cofactor binding
C2I05_12825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2I05_12830	COG2223	nitrite transmembrane transporter activity
C2I05_12835	COG1469	GTP cyclohydrolase I activity
C2I05_12855	COG0523	cobalamin synthesis protein
C2I05_12860	COG0765	amino acid transport
C2I05_12865	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2I05_12870	COG1714	RDD family
C2I05_12880	COG1846	Transcriptional regulator
C2I05_12890	COG3842	ATPase activity
C2I05_12895	COG2723	6-phospho-beta-galactosidase activity
C2I05_12905	COG3209	COG3209 Rhs family protein
C2I05_12910	COG3290	protein histidine kinase activity
C2I05_12910	COG0840	transmembrane signaling receptor activity
C2I05_12915	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2I05_12920	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C2I05_12925	COG1733	regulation of RNA biosynthetic process
C2I05_12930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2I05_12935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2I05_12940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2I05_12945	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C2I05_12950	COG2814	Major facilitator Superfamily
C2I05_12960	COG0697	spore germination
C2I05_12965	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I05_12975	COG2364	Membrane
C2I05_12980	COG1126	abc transporter atp-binding protein
C2I05_12985	COG0765	amino acid transport
C2I05_12990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2I05_12995	COG0583	DNA-binding transcription factor activity
C2I05_13000	COG0163	prenyltransferase activity
C2I05_13005	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2I05_13020	COG0596	Alpha beta hydrolase
C2I05_13025	COG3104	oligopeptide transport
C2I05_13030	COG5434	Belongs to the glycosyl hydrolase 28 family
C2I05_13040	COG0697	spore germination
C2I05_13050	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2I05_13055	COG1136	(ABC) transporter
C2I05_13060	COG0577	efflux transmembrane transporter activity
C2I05_13065	COG0745	RESPONSE REGULATOR receiver
C2I05_13070	COG5002	protein histidine kinase activity
C2I05_13070	COG3850	Histidine kinase
C2I05_13075	COG0457	Tetratricopeptide repeat
C2I05_13095	COG0527	aspartate kinase activity
C2I05_13100	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I05_13105	COG4605	iron ion homeostasis
C2I05_13110	COG4604	ABC transporter, ATP-binding protein
C2I05_13115	COG4607	ABC-type enterochelin transport system periplasmic component
C2I05_13120	COG2814	Major facilitator Superfamily
C2I05_13125	COG1309	transcriptional regulator
C2I05_13130	COG0778	Nitroreductase
C2I05_13135	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C2I05_13140	COG0640	Transcriptional regulator
C2I05_13145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I05_13150	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2I05_13155	COG1012	belongs to the aldehyde dehydrogenase family
C2I05_13180	COG4975	Glucose uptake
C2I05_13185	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_13190	COG4549	nuclear export factor GLE1
C2I05_13195	COG1276	copper resistance
C2I05_13195	COG2372	response to copper ion
C2I05_13200	COG1349	DNA-binding transcription factor activity
C2I05_13210	COG2213	PTS system mannitol-specific
C2I05_13215	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I05_13220	COG0246	Mannitol dehydrogenase
C2I05_13225	COG0473	3-isopropylmalate dehydrogenase activity
C2I05_13230	COG0681	Belongs to the peptidase S26 family
C2I05_13235	COG0412	Dienelactone hydrolase
C2I05_13240	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2I05_13250	COG0561	phosphatase activity
C2I05_13255	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C2I05_13260	COG1914	H( )-stimulated, divalent metal cation uptake system
C2I05_13265	COG4336	lyase activity
C2I05_13270	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C2I05_13275	COG1984	allophanate hydrolase subunit 2
C2I05_13280	COG1414	Transcriptional regulator
C2I05_13285	COG2755	lipolytic protein G-D-S-L family
C2I05_13295	COG2329	Antibiotic biosynthesis monooxygenase
C2I05_13300	COG0768	penicillin binding
C2I05_13305	COG4989	oxidoreductase activity
C2I05_13310	COG3711	transcriptional antiterminator
C2I05_13315	COG0318	PFAM AMP-dependent synthetase and ligase
C2I05_13320	COG2226	methyltransferase
C2I05_13325	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_13330	COG1917	Cupin 2, conserved barrel domain protein
C2I05_13335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I05_13340	COG3871	stress protein (general stress protein 26)
C2I05_13350	COG2814	Major facilitator Superfamily
C2I05_13355	COG1522	sequence-specific DNA binding
C2I05_13360	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2I05_13360	COG0551	DNA topoisomerase type I activity
C2I05_13365	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C2I05_13370	COG3706	GGDEF domain
C2I05_13375	COG5298	Protein conserved in bacteria
C2I05_13380	COG1215	transferase activity, transferring glycosyl groups
C2I05_13390	COG0531	amino acid
C2I05_13395	COG0494	nUDIX hydrolase
C2I05_13400	COG0028	Belongs to the TPP enzyme family
C2I05_13410	COG1914	H( )-stimulated, divalent metal cation uptake system
C2I05_13415	COG2261	transglycosylase associated protein
C2I05_13420	COG4876	unkown
C2I05_13425	COG2217	Heavy metal translocating P-type atpase
C2I05_13430	COG3729	General stress protein
C2I05_13435	COG0662	Cupin 2, conserved barrel domain protein
C2I05_13440	COG2329	Antibiotic biosynthesis monooxygenase
C2I05_13445	COG3546	catalase activity
C2I05_13450	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C2I05_13455	COG3290	protein histidine kinase activity
C2I05_13460	COG4565	transcriptional regulatory protein
C2I05_13465	COG1301	dicarboxylic acid transport
C2I05_13470	COG0628	permease
C2I05_13475	COG1131	(ABC) transporter
C2I05_13480	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2I05_13490	COG1960	acyl-CoA dehydrogenase activity
C2I05_13505	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2I05_13510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2I05_13515	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2I05_13520	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2I05_13530	COG0513	Belongs to the DEAD box helicase family
C2I05_13535	COG3402	PFAM membrane-flanked domain
C2I05_13540	COG3428	Bacterial PH domain
C2I05_13545	COG0705	Rhomboid family
C2I05_13550	COG0736	holo-[acyl-carrier-protein] synthase activity
C2I05_13555	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2I05_13560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2I05_13565	COG0864	Transcriptional regulator
C2I05_13570	COG2337	Toxic component of a toxin-antitoxin (TA) module
C2I05_13575	COG1366	Belongs to the anti-sigma-factor antagonist family
C2I05_13580	COG1366	Belongs to the anti-sigma-factor antagonist family
C2I05_13585	COG2172	sigma factor antagonist activity
C2I05_13590	COG2208	phosphoserine phosphatase activity
C2I05_13595	COG1366	Belongs to the anti-sigma-factor antagonist family
C2I05_13600	COG2172	sigma factor antagonist activity
C2I05_13605	COG1191	sigma factor activity
C2I05_13610	COG2208	phosphoserine phosphatase activity
C2I05_13620	COG1673	EVE domain
C2I05_13625	COG1846	Transcriptional regulator
C2I05_13630	COG2183	response to ionizing radiation
C2I05_13640	COG3091	SprT-like family
C2I05_13680	COG0582	viral genome integration into host DNA
C2I05_13685	COG2856	Zn peptidase
C2I05_13690	COG1396	sequence-specific DNA binding
C2I05_13720	COG1674	ftsk spoiiie
C2I05_13725	COG2946	Replication initiation factor
C2I05_13760	COG0433	COG0433 Predicted ATPase
C2I05_13770	COG5644	endopeptidase inhibitor activity
C2I05_13775	COG0741	lytic transglycosylase activity
C2I05_13775	COG0791	NLP P60 protein
C2I05_13795	COG0457	Tetratricopeptide repeat
C2I05_13810	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2I05_13815	COG1522	sequence-specific DNA binding
C2I05_13820	COG1522	sequence-specific DNA binding
C2I05_13825	COG1335	isochorismatase
C2I05_13830	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2I05_13835	COG2814	Major facilitator Superfamily
C2I05_13850	COG3239	Fatty acid desaturase
C2I05_13855	COG1278	Cold shock
C2I05_13860	COG1329	Transcriptional regulator
C2I05_13875	COG1917	Cupin 2, conserved barrel domain protein
C2I05_13875	COG2207	Transcriptional regulator
C2I05_13880	COG0697	spore germination
C2I05_13885	COG2207	Transcriptional regulator
C2I05_13885	COG3708	Transcriptional regulator
C2I05_13895	COG0477	Major facilitator Superfamily
C2I05_13905	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
C2I05_13920	COG0697	spore germination
C2I05_13925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I05_13930	COG2030	dehydratase
C2I05_13935	COG3545	Serine hydrolase
C2I05_13940	COG1733	regulation of RNA biosynthetic process
C2I05_13945	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I05_13950	COG0640	Transcriptional regulator
C2I05_13955	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2I05_13960	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2I05_13965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I05_13985	COG5002	protein histidine kinase activity
C2I05_13990	COG0745	RESPONSE REGULATOR receiver
C2I05_13995	COG0697	spore germination
C2I05_14000	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I05_14005	COG0076	glutamate decarboxylase activity
C2I05_14010	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2I05_14015	COG0640	Transcriptional regulator
C2I05_14020	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2I05_14035	COG4585	Histidine kinase
C2I05_14040	COG2197	response regulator
C2I05_14045	COG2409	Drug exporters of the RND superfamily
C2I05_14050	COG1811	Na channel or pump
C2I05_14055	COG4978	Transcriptional regulator
C2I05_14055	COG0789	Transcriptional regulator
C2I05_14060	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2I05_14065	COG0778	Nitroreductase
C2I05_14070	COG0346	lactoylglutathione lyase activity
C2I05_14075	COG2259	Doxx family
C2I05_14080	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2I05_14100	COG2323	membrane
C2I05_14105	COG0071	Belongs to the small heat shock protein (HSP20) family
C2I05_14120	COG1309	transcriptional regulator
C2I05_14130	COG0456	acetyltransferase
C2I05_14135	COG0488	(ABC) transporter
C2I05_14140	COG1113	amino acid transport
C2I05_14145	COG2318	DinB family
C2I05_14150	COG1846	Transcriptional regulator
C2I05_14155	COG1033	growth of symbiont in host cell
C2I05_14155	COG2409	Drug exporters of the RND superfamily
C2I05_14160	COG0778	Nitroreductase
C2I05_14165	COG1846	Transcriptional regulator
C2I05_14170	COG2814	Major facilitator Superfamily
C2I05_14175	COG0730	response to heat
C2I05_14180	COG1802	Transcriptional regulator
C2I05_14185	COG3858	chitin binding
C2I05_14185	COG1388	LysM domain
C2I05_14190	COG1819	glycosyl
C2I05_14200	COG1785	Belongs to the alkaline phosphatase family
C2I05_14205	COG5646	InterPro IPR014922
C2I05_14215	COG0454	-acetyltransferase
C2I05_14220	COG1078	dGTPase activity
C2I05_14225	COG1388	LysM domain
C2I05_14230	COG2814	Major facilitator Superfamily
C2I05_14235	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2I05_14240	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2I05_14245	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2I05_14250	COG2723	6-phospho-beta-galactosidase activity
C2I05_14255	COG2188	Transcriptional regulator
C2I05_14260	COG1940	carbohydrate kinase activity
C2I05_14265	COG1482	cell wall glycoprotein biosynthetic process
C2I05_14270	COG4124	Belongs to the glycosyl hydrolase 26 family
C2I05_14315	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C2I05_14320	COG0802	atpase or kinase
C2I05_14325	COG1214	PFAM Peptidase M22, glycoprotease
C2I05_14330	COG0456	acetyltransferase
C2I05_14335	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C2I05_14340	COG0488	(ABC) transporter
C2I05_14345	COG0315	cyclic pyranopterin monophosphate synthase activity
C2I05_14350	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C2I05_14355	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2I05_14360	COG0805	protein transport
C2I05_14375	COG1266	CAAX protease self-immunity
C2I05_14385	COG0459	protein refolding
C2I05_14415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I05_14425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2I05_14425	COG0072	phenylalanine-tRNA ligase activity
C2I05_14450	COG1073	alpha beta
C2I05_14455	COG0457	Tetratricopeptide repeat
C2I05_14460	COG1063	alcohol dehydrogenase
C2I05_14465	COG2211	Major facilitator Superfamily
C2I05_14470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2I05_14475	COG1842	Phage shock protein A
C2I05_14480	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2I05_14485	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C2I05_14490	COG4260	virion core protein, lumpy skin disease virus
C2I05_14500	COG2814	Major facilitator Superfamily
C2I05_14505	COG1063	alcohol dehydrogenase
C2I05_14510	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2I05_14515	COG0823	Involved in the tonB-independent uptake of proteins
C2I05_14530	COG2267	carboxylic ester hydrolase activity
C2I05_14540	COG2132	Multicopper oxidase
C2I05_14545	COG1113	amino acid transport
C2I05_14555	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2I05_14560	COG0714	Associated with various cellular activities
C2I05_14565	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
C2I05_14570	COG1305	Transglutaminase-like
C2I05_14575	COG0519	Catalyzes the synthesis of GMP from XMP
C2I05_14575	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2I05_14590	COG2252	PERMEase
C2I05_14595	COG3064	Membrane
C2I05_14605	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
C2I05_14615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2I05_14620	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2I05_14625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2I05_14630	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C2I05_14635	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2I05_14640	COG0047	phosphoribosylformylglycinamidine synthase activity
C2I05_14645	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2I05_14650	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2I05_14655	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C2I05_14660	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2I05_14665	COG0138	bifunctional purine biosynthesis protein purh
C2I05_14670	COG0151	Belongs to the GarS family
C2I05_14675	COG1522	sequence-specific DNA binding
C2I05_14680	COG0531	amino acid
C2I05_14690	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C2I05_14695	COG1470	cell adhesion involved in biofilm formation
C2I05_14700	COG4496	protein, YerC YecD
C2I05_14705	COG0069	glutamate synthase activity
C2I05_14710	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
C2I05_14715	COG0210	DNA helicase
C2I05_14720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2I05_14730	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2I05_14735	COG1285	pathogenesis
C2I05_14740	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2I05_14745	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2I05_14750	COG0154	amidase activity
C2I05_14755	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2I05_14760	COG1309	transcriptional regulator
C2I05_14765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2I05_14770	COG1597	lipid kinase activity
C2I05_14775	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2I05_14800	COG0457	Tetratricopeptide repeat
C2I05_14825	COG5444	nuclease activity
C2I05_14835	COG3586	endonuclease activity
C2I05_14840	COG3391	amine dehydrogenase activity
C2I05_14850	COG0457	Tetratricopeptide repeat
C2I05_14860	COG0217	transcriptional regulatory protein
C2I05_14870	COG1309	transcriptional regulator
C2I05_14875	COG3631	Ketosteroid isomerase-related protein
C2I05_14880	COG0702	epimerase
C2I05_14895	COG3546	catalase activity
C2I05_14900	COG0454	-acetyltransferase
C2I05_14910	COG5578	integral membrane protein
C2I05_14915	COG2972	Histidine kinase
C2I05_14920	COG2207	Transcriptional regulator
C2I05_14920	COG4753	response regulator
C2I05_14925	COG1653	transport
C2I05_14930	COG1175	transmembrane transport
C2I05_14935	COG0395	ABC-type sugar transport system, permease component
C2I05_14940	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2I05_14945	COG2207	Transcriptional regulator
C2I05_14950	COG2755	lipolytic protein G-D-S-L family
C2I05_14960	COG5578	integral membrane protein
C2I05_14965	COG3401	FG-GAP repeat protein
C2I05_14970	COG3401	FG-GAP repeat protein
C2I05_14975	COG2755	lipolytic protein G-D-S-L family
C2I05_14980	COG1874	Beta-galactosidase
C2I05_14990	COG1653	transport
C2I05_14995	COG4209	transmembrane transport
C2I05_15000	COG0395	ABC-type sugar transport system, permease component
C2I05_15005	COG1486	melibiose metabolic process
C2I05_15010	COG2323	membrane
C2I05_15015	COG2329	Antibiotic biosynthesis monooxygenase
C2I05_15020	COG0346	lactoylglutathione lyase activity
C2I05_15035	COG5583	Uncharacterized small protein (DUF2292)
C2I05_15040	COG0670	Belongs to the BI1 family
C2I05_15050	COG1846	Transcriptional regulator
C2I05_15055	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2I05_15070	COG2124	cytochrome p450
C2I05_15070	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2I05_15080	COG1368	sulfuric ester hydrolase activity
C2I05_15085	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2I05_15090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2I05_15095	COG1442	glycosyl transferase family 8
C2I05_15100	COG1216	Glycosyl transferase, family 2
C2I05_15105	COG1442	glycosyl transferase family 8
C2I05_15110	COG2223	nitrite transmembrane transporter activity
C2I05_15115	COG1011	Hydrolase
C2I05_15120	COG0531	amino acid
C2I05_15125	COG1012	belongs to the aldehyde dehydrogenase family
C2I05_15130	COG0840	transmembrane signaling receptor activity
C2I05_15135	COG0488	(ABC) transporter
C2I05_15145	COG0789	Transcriptional regulator
C2I05_15150	COG2814	Major facilitator Superfamily
C2I05_15155	COG1404	Belongs to the peptidase S8 family
C2I05_15170	COG0488	(ABC) transporter
C2I05_15175	COG0513	Belongs to the DEAD box helicase family
C2I05_15180	COG0456	acetyltransferase
C2I05_15185	COG2130	NADP-dependent
C2I05_15190	COG1120	ATPase activity
C2I05_15195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I05_15200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I05_15205	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C2I05_15225	COG3866	Pectate lyase
C2I05_15230	COG0471	metal ion transport
C2I05_15235	COG3290	protein histidine kinase activity
C2I05_15240	COG4565	transcriptional regulatory protein
C2I05_15245	COG3181	Tripartite tricarboxylate transporter family receptor
C2I05_15250	COG2851	Citrate transporter
C2I05_15255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I05_15260	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
C2I05_15265	COG1254	Belongs to the acylphosphatase family
C2I05_15270	COG2258	MOSC domain
C2I05_15290	COG0024	Methionine aminopeptidase
C2I05_15295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I05_15295	COG1263	PTS System
C2I05_15300	COG1368	sulfuric ester hydrolase activity
C2I05_15315	COG1115	amino acid carrier protein
C2I05_15320	COG0531	amino acid
C2I05_15335	COG0697	spore germination
C2I05_15340	COG1263	PTS System
C2I05_15340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I05_15345	COG0366	Alpha amylase catalytic
C2I05_15350	COG2188	Transcriptional regulator
C2I05_15355	COG0778	Nitroreductase
C2I05_15360	COG0737	Belongs to the 5'-nucleotidase family
C2I05_15365	COG0693	protein deglycase activity
C2I05_15370	COG2814	Major facilitator Superfamily
C2I05_15375	COG4840	Belongs to the UPF0435 family
C2I05_15380	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2I05_15385	COG4980	gas vesicle protein
C2I05_15390	COG1295	ribonuclease BN
C2I05_15395	COG0477	Major facilitator Superfamily
C2I05_15400	COG0387	Pfam Sodium calcium exchanger
C2I05_15410	COG0668	transmembrane transport
C2I05_15415	COG0535	radical SAM domain protein
C2I05_15425	COG0726	polysaccharide deacetylase
C2I05_15430	COG2084	Dehydrogenase
C2I05_15435	COG0598	Magnesium transport protein CorA
C2I05_15440	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2I05_15445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2I05_15460	COG4637	Psort location Cytoplasmic, score
C2I05_15465	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2I05_15470	COG0022	dehydrogenase e1 component
C2I05_15475	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2I05_15480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2I05_15485	COG3284	Transcriptional regulator
C2I05_15495	COG1742	UPF0060 membrane protein
C2I05_15520	COG4842	Belongs to the WXG100 family
C2I05_15545	COG5444	nuclease activity
C2I05_15560	COG1486	melibiose metabolic process
C2I05_15565	COG1737	Transcriptional regulator
C2I05_15570	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I05_15570	COG1263	PTS System
C2I05_15575	COG1132	(ABC) transporter
C2I05_15580	COG1132	(ABC) transporter
C2I05_15585	COG2259	Doxx family
C2I05_15590	COG2514	catechol 2,3-dioxygenase activity
C2I05_15595	COG4585	Histidine kinase
C2I05_15600	COG2197	response regulator
C2I05_15610	COG1131	(ABC) transporter
C2I05_15615	COG1511	domain protein
C2I05_15615	COG0842	Transport permease protein
C2I05_15620	COG0842	Transport permease protein
C2I05_15625	COG1695	Transcriptional regulator
C2I05_15630	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C2I05_15635	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
C2I05_15640	COG2318	DinB family
C2I05_15645	COG2814	Major facilitator Superfamily
C2I05_15650	COG1846	Transcriptional regulator
C2I05_15655	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C2I05_15655	COG0392	lysyltransferase activity
C2I05_15660	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2I05_15665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I05_15670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2I05_15675	COG0384	phenazine biosynthesis protein PhzF
C2I05_15680	COG0778	Nitroreductase
C2I05_15695	COG1090	epimerase
C2I05_15700	COG2137	regulation of response to DNA damage stimulus
C2I05_15710	COG2814	Major facilitator Superfamily
C2I05_15725	COG3103	Sh3 type 3 domain protein
C2I05_15730	COG5658	integral membrane protein
C2I05_15735	COG0596	Alpha beta hydrolase
C2I05_15740	COG0463	Glycosyl transferase, family 2
C2I05_15745	COG4485	Bacterial membrane protein, YfhO
C2I05_15750	COG1988	membrane-bound metal-dependent
C2I05_15755	COG1194	a g-specific adenine glycosylase
C2I05_15765	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_15780	COG3557	Belongs to the UPF0374 family
C2I05_15785	COG1132	(ABC) transporter
C2I05_15790	COG4129	membrane
C2I05_15795	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2I05_15800	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2I05_15805	COG0735	belongs to the Fur family
C2I05_15935	COG4326	sporulation control protein
C2I05_15945	COG5577	PFAM Coat F domain
C2I05_15950	COG3340	Belongs to the peptidase S51 family
C2I05_15955	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C2I05_15965	COG0753	catalase activity
C2I05_15970	COG1116	anion transmembrane transporter activity
C2I05_15975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2I05_15980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2I05_15985	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2I05_15995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C2I05_16005	COG1476	TRANSCRIPTIONal
C2I05_16015	COG3382	B3 4 domain protein
C2I05_16020	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2I05_16030	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2I05_16035	COG0789	Transcriptional regulator
C2I05_16040	COG1664	Polymer-forming cytoskeletal
C2I05_16045	COG1664	Polymer-forming cytoskeletal
C2I05_16050	COG2766	serine protein kinase
C2I05_16055	COG2718	Belongs to the UPF0229 family
C2I05_16060	COG1846	Transcriptional regulator
C2I05_16065	COG1566	PFAM secretion protein HlyD family protein
C2I05_16070	COG2814	Major facilitator Superfamily
C2I05_16075	COG0655	NAD(P)H dehydrogenase (quinone) activity
C2I05_16095	COG1725	Transcriptional regulator
C2I05_16100	COG1131	(ABC) transporter
C2I05_16105	COG1131	(ABC) transporter
C2I05_16110	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2I05_16115	COG1278	Cold shock
C2I05_16125	COG1464	Belongs to the NlpA lipoprotein family
C2I05_16130	COG3706	GGDEF domain
C2I05_16135	COG1823	symporter activity
C2I05_16165	COG5577	PFAM Coat F domain
C2I05_16170	COG0737	Belongs to the 5'-nucleotidase family
C2I05_16170	COG4085	toxin activity
C2I05_16170	COG1525	nuclease
C2I05_16175	COG3764	Sortase (surface protein transpeptidase)
C2I05_16180	COG0564	pseudouridine synthase activity
C2I05_16190	COG0517	IMP dehydrogenase activity
C2I05_16195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2I05_16200	COG3153	acetyltransferase
C2I05_16200	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2I05_16205	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2I05_16210	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
C2I05_16215	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2I05_16220	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2I05_16225	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2I05_16230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2I05_16235	COG4585	Histidine kinase
C2I05_16235	COG2203	Gaf domain
C2I05_16240	COG2197	response regulator
C2I05_16245	COG0431	NADPH-dependent FMN reductase
C2I05_16260	COG1388	LysM domain
C2I05_16260	COG0791	NLP P60 protein
C2I05_16265	COG1959	2 iron, 2 sulfur cluster binding
C2I05_16270	COG0668	transmembrane transport
C2I05_16275	COG2719	SpoVR family
C2I05_16280	COG1785	Belongs to the alkaline phosphatase family
C2I05_16285	COG0791	NLP P60 protein
C2I05_16285	COG1388	LysM domain
C2I05_16290	COG0583	DNA-binding transcription factor activity
C2I05_16295	COG0372	Belongs to the citrate synthase family
C2I05_16300	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_16305	COG0531	amino acid
C2I05_16310	COG0733	neurotransmitter:sodium symporter activity
C2I05_16315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2I05_16320	COG0456	acetyltransferase
C2I05_16335	COG1595	DNA-templated transcription, initiation
C2I05_16340	COG0667	Aldo Keto reductase
C2I05_16345	COG0204	Acyl-transferase
C2I05_16350	COG1253	flavin adenine dinucleotide binding
C2I05_16355	COG0789	Transcriptional regulator
C2I05_16360	COG0436	Aminotransferase
C2I05_16365	COG1253	flavin adenine dinucleotide binding
C2I05_16370	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2I05_16375	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2I05_16380	COG0584	glycerophosphoryl diester phosphodiesterase
C2I05_16390	COG0668	transmembrane transport
C2I05_16395	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2I05_16400	COG0726	polysaccharide deacetylase
C2I05_16405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2I05_16410	COG1757	Na H antiporter
C2I05_16415	COG0589	response to stress
C2I05_16425	COG1132	(ABC) transporter
C2I05_16430	COG1132	(ABC) transporter
C2I05_16435	COG0702	epimerase
C2I05_16455	COG0189	ligase activity
C2I05_16460	COG0189	ligase activity
C2I05_16465	COG4399	Belongs to the UPF0754 family
C2I05_16470	COG3679	Belongs to the UPF0342 family
C2I05_16475	COG4335	DNA alkylation repair
C2I05_16480	COG0561	phosphatase activity
C2I05_16485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2I05_16490	COG0475	glutathione-regulated potassium exporter activity
C2I05_16495	COG0490	domain, Protein
C2I05_16505	COG1024	Enoyl-CoA hydratase
C2I05_16515	COG4152	abc transporter atp-binding protein
C2I05_16520	COG1668	transmembrane transport
C2I05_16525	COG0420	3'-5' exonuclease activity
C2I05_16530	COG4717	serine-type aminopeptidase activity
C2I05_16535	COG3481	metal-dependent phosphohydrolase, HD sub domain
C2I05_16545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2I05_16575	COG1846	Transcriptional regulator
C2I05_16580	COG4980	gas vesicle protein
C2I05_16595	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C2I05_16600	COG0537	adenosine 5'-monophosphoramidase activity
C2I05_16605	COG1131	(ABC) transporter
C2I05_16610	COG4473	ABC transporter
C2I05_16620	COG1473	amidohydrolase
C2I05_16625	COG3069	C4-dicarboxylate transmembrane transporter activity
C2I05_16635	COG2329	Antibiotic biosynthesis monooxygenase
C2I05_16640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2I05_16645	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C2I05_16650	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C2I05_16655	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C2I05_16660	COG1309	transcriptional regulator
C2I05_16665	COG1511	domain protein
C2I05_16670	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2I05_16675	COG4377	Putative membrane peptidase family (DUF2324)
C2I05_16685	COG1363	Peptidase, m42
C2I05_16690	COG4405	Protein conserved in bacteria
C2I05_16695	COG1301	dicarboxylic acid transport
C2I05_16705	COG1234	tRNA 3'-trailer cleavage
C2I05_16710	COG0095	Lipoate-protein ligase
C2I05_16715	COG0702	epimerase
C2I05_16720	COG0318	PFAM AMP-dependent synthetase and ligase
C2I05_16730	COG0501	Belongs to the peptidase M48B family
C2I05_16740	COG0456	acetyltransferase
C2I05_16745	COG0604	alcohol dehydrogenase
C2I05_16750	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C2I05_16755	COG0406	alpha-ribazole phosphatase activity
C2I05_16760	COG0183	Belongs to the thiolase family
C2I05_16765	COG0318	PFAM AMP-dependent synthetase and ligase
C2I05_16770	COG1268	BioY protein
C2I05_16775	COG0840	transmembrane signaling receptor activity
C2I05_16780	COG0723	plastoquinol--plastocyanin reductase activity
C2I05_16780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2I05_16785	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_16795	COG4903	ComK protein
C2I05_16800	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_16810	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2I05_16825	COG0398	Pfam SNARE associated Golgi protein
C2I05_16830	COG0681	Belongs to the peptidase S26 family
C2I05_16835	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2I05_16840	COG1846	Transcriptional regulator
C2I05_16855	COG0738	Major facilitator superfamily
C2I05_16860	COG0673	inositol 2-dehydrogenase activity
C2I05_16865	COG0561	phosphatase activity
C2I05_16870	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2I05_16875	COG1609	Transcriptional regulator
C2I05_16880	COG3180	Ammonia monooxygenase
C2I05_16885	COG2814	Major facilitator Superfamily
C2I05_16885	COG0477	Major facilitator Superfamily
C2I05_16890	COG4533	DNA binding
C2I05_16900	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
C2I05_16905	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C2I05_16910	COG1074	ATP-dependent DNA helicase activity
C2I05_16915	COG0420	3'-5' exonuclease activity
C2I05_16920	COG0419	ATPase involved in DNA repair
C2I05_16925	COG1403	HNH endonuclease
C2I05_16965	COG5337	Spore coat protein CotH
C2I05_16970	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2I05_16980	COG1404	Belongs to the peptidase S8 family
C2I05_16990	COG0367	asparagine synthase
C2I05_16995	COG2318	DinB family
C2I05_17000	COG1562	ergosterol biosynthetic process
C2I05_17005	COG0534	Mate efflux family protein
C2I05_17010	COG2207	Transcriptional regulator
C2I05_17010	COG1917	Cupin 2, conserved barrel domain protein
C2I05_17015	COG1609	Transcriptional regulator
C2I05_17020	COG0673	inositol 2-dehydrogenase activity
C2I05_17025	COG2318	DinB family
C2I05_17030	COG1279	arginine transmembrane transporter activity
C2I05_17040	COG1357	PFAM Pentapeptide repeats (8 copies)
C2I05_17045	COG2267	carboxylic ester hydrolase activity
C2I05_17050	COG0529	Catalyzes the synthesis of activated sulfate
C2I05_17055	COG2046	Belongs to the sulfate adenylyltransferase family
C2I05_17060	COG0175	sulfate reduction
C2I05_17065	COG2045	Belongs to the ComB family
C2I05_17070	COG1809	phosphosulfolactate synthase activity
C2I05_17075	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I05_17080	COG4948	Mandelate Racemase Muconate Lactonizing
C2I05_17085	COG2814	Major facilitator Superfamily
C2I05_17090	COG0454	-acetyltransferase
C2I05_17095	COG2153	protein acetylation
C2I05_17100	COG0646	methionine synthase
C2I05_17100	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C2I05_17105	COG1666	GTP binding
C2I05_17110	COG2996	Protein conserved in bacteria
C2I05_17130	COG1695	Transcriptional regulator
C2I05_17145	COG3227	Zinc metalloprotease (Elastase)
C2I05_17150	COG1307	EDD domain protein, DegV family
C2I05_17155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2I05_17170	COG0561	phosphatase activity
C2I05_17175	COG1073	alpha beta
C2I05_17180	COG2151	metal-sulfur cluster biosynthetic enzyme
C2I05_17190	COG0277	FAD linked oxidase domain protein
C2I05_17195	COG2271	Major facilitator Superfamily
C2I05_17200	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2I05_17205	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C2I05_17215	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2I05_17220	COG0505	Belongs to the CarA family
C2I05_17225	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2I05_17230	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2I05_17245	COG2267	carboxylic ester hydrolase activity
C2I05_17255	COG1744	ABC transporter substrate-binding protein PnrA-like
C2I05_17270	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2I05_17275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2I05_17280	COG5504	Zn-dependent protease
C2I05_17285	COG0444	Belongs to the ABC transporter superfamily
C2I05_17290	COG4608	Belongs to the ABC transporter superfamily
C2I05_17300	COG0601	transmembrane transport
C2I05_17305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2I05_17315	COG0180	Tryptophanyl-tRNA synthetase
C2I05_17320	COG4166	transmembrane transport
C2I05_17325	COG0601	transmembrane transport
C2I05_17330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2I05_17335	COG0444	Belongs to the ABC transporter superfamily
C2I05_17340	COG4608	Belongs to the ABC transporter superfamily
C2I05_17345	COG2814	Major facilitator Superfamily
C2I05_17350	COG0456	acetyltransferase
C2I05_17355	COG1393	Belongs to the ArsC family
C2I05_17360	COG0861	Integral membrane protein TerC family
C2I05_17365	COG4862	establishment of competence for transformation
C2I05_17370	COG4469	Competence protein
C2I05_17375	COG1164	Oligoendopeptidase f
C2I05_17390	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C2I05_17395	COG2346	COG2346, Truncated hemoglobins
C2I05_17400	COG0741	lytic transglycosylase activity
C2I05_17405	COG4116	CYTH
C2I05_17415	COG2357	RelA SpoT domain protein
C2I05_17420	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2I05_17425	COG0564	pseudouridine synthase activity
C2I05_17430	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2I05_17435	COG0475	glutathione-regulated potassium exporter activity
C2I05_17435	COG0569	domain protein
C2I05_17440	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2I05_17445	COG0352	thiamine-phosphate diphosphorylase activity
C2I05_17450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2I05_17455	COG2104	thiamine diphosphate biosynthetic process
C2I05_17460	COG2022	thiamine diphosphate biosynthetic process
C2I05_17465	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2I05_17470	COG0351	phosphomethylpyrimidine kinase
C2I05_17475	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2I05_17530	COG0210	DNA helicase
C2I05_17540	COG2153	protein acetylation
C2I05_17545	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2I05_17550	COG2382	esterase
C2I05_17555	COG0626	cystathionine gamma-synthase activity
C2I05_17560	COG0626	cystathionine gamma-synthase activity
C2I05_17565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I05_17570	COG5505	Protein of unknown function (DUF819)
C2I05_17595	COG5444	nuclease activity
C2I05_17620	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C2I05_17630	COG3711	transcriptional antiterminator
C2I05_17630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I05_17635	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I05_17635	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2I05_17635	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2I05_17640	COG1482	cell wall glycoprotein biosynthetic process
C2I05_17650	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I05_17660	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2I05_17680	COG0109	protoheme IX farnesyltransferase activity
C2I05_17690	COG0726	polysaccharide deacetylase
C2I05_17705	COG5504	Zn-dependent protease
C2I05_17710	COG2205	protein histidine kinase activity
C2I05_17720	COG3383	formate dehydrogenase (NAD+) activity
C2I05_17725	COG2427	Protein of unknown function (DUF1641)
C2I05_17735	COG1051	belongs to the nudix hydrolase family
C2I05_17745	COG2124	cytochrome p450
C2I05_17750	COG1819	glycosyl
C2I05_17760	COG1587	Uroporphyrinogen-III synthase
C2I05_17765	COG0390	transport system, permease component
C2I05_17770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2I05_17775	COG0697	spore germination
C2I05_17780	COG4297	protein containing double-stranded beta helix domain
C2I05_17790	COG1252	NADH dehydrogenase
C2I05_17795	COG1904	glucuronate isomerase
C2I05_17800	COG2211	Major facilitator Superfamily
C2I05_17805	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C2I05_17810	COG1063	alcohol dehydrogenase
C2I05_17815	COG1312	Catalyzes the dehydration of D-mannonate
C2I05_17820	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_17825	COG2271	Major facilitator Superfamily
C2I05_17830	COG1609	Transcriptional regulator
C2I05_17835	COG0246	Mannitol dehydrogenase
C2I05_17840	COG2721	sulfolactate sulfo-lyase activity
C2I05_17845	COG0730	response to heat
C2I05_17850	COG2318	DinB family
C2I05_17855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2I05_17860	COG0457	Tetratricopeptide repeat
C2I05_17870	COG2350	Protein conserved in bacteria
C2I05_17875	COG3409	Peptidoglycan-binding domain 1 protein
C2I05_17875	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2I05_17875	COG1388	LysM domain
C2I05_17885	COG4195	phage-related replication protein
C2I05_17895	COG2856	Zn peptidase
C2I05_17900	COG1396	sequence-specific DNA binding
C2I05_17910	COG1522	sequence-specific DNA binding
C2I05_17915	COG1484	DNA-dependent DNA replication
C2I05_17935	COG1595	DNA-templated transcription, initiation
C2I05_17940	COG5484	DNA packaging
C2I05_17940	COG3728	DNA packaging
C2I05_17945	COG1783	phage Terminase large subunit
C2I05_17950	COG5518	Phage portal protein
C2I05_17955	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C2I05_17960	COG4653	Phage capsid family
C2I05_18010	COG3953	SLT domain
C2I05_18010	COG5412	phage tail tape measure protein
C2I05_18010	COG5412	phage tail tape measure protein
C2I05_18010	COG3953	SLT domain
C2I05_18015	COG1652	LysM domain
C2I05_18020	COG4193	domain, Protein
C2I05_18030	COG3628	GPW Gp25 family protein
C2I05_18035	COG3299	homolog of phage Mu protein gp47
C2I05_18040	COG3778	Protein conserved in bacteria
C2I05_18080	COG3409	Peptidoglycan-binding domain 1 protein
C2I05_18080	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2I05_18095	COG0306	phosphate transporter
C2I05_18100	COG1392	Phosphate transport regulator
C2I05_18105	COG0531	amino acid
C2I05_18110	COG0346	lactoylglutathione lyase activity
C2I05_18115	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2I05_18120	COG0463	Glycosyl transferase, family 2
C2I05_18130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2I05_18135	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2I05_18140	COG2362	D-Aminopeptidase
C2I05_18145	COG0601	transmembrane transport
C2I05_18150	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2I05_18155	COG0444	Belongs to the ABC transporter superfamily
C2I05_18160	COG4166	transmembrane transport
C2I05_18165	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2I05_18170	COG4948	Mandelate Racemase Muconate Lactonizing
C2I05_18175	COG0791	NLP P60 protein
C2I05_18180	COG4608	Belongs to the ABC transporter superfamily
C2I05_18185	COG2706	6-phosphogluconolactonase activity
C2I05_18190	COG1834	amidinotransferase
C2I05_18195	COG1607	acyl-coa hydrolase
C2I05_18200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2I05_18200	COG1017	nitric oxide dioxygenase activity
C2I05_18210	COG2323	membrane
C2I05_18215	COG2318	DinB family
C2I05_18220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I05_18225	COG2076	Multidrug Resistance protein
C2I05_18230	COG2076	Multidrug Resistance protein
C2I05_18235	COG0788	formyltetrahydrofolate deformylase activity
C2I05_18240	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C2I05_18245	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C2I05_18250	COG1764	response to oxidative stress
C2I05_18255	COG1846	Transcriptional regulator
C2I05_18260	COG1764	response to oxidative stress
C2I05_18265	COG0590	tRNA wobble adenosine to inosine editing
C2I05_18270	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2I05_18275	COG1404	Belongs to the peptidase S8 family
C2I05_18280	COG1366	Belongs to the anti-sigma-factor antagonist family
C2I05_18285	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C2I05_18290	COG1122	ATPase activity
C2I05_18295	COG4721	ABC-type cobalt transport system, permease component
C2I05_18305	COG0745	RESPONSE REGULATOR receiver
C2I05_18310	COG5002	protein histidine kinase activity
C2I05_18310	COG3850	Histidine kinase
C2I05_18315	COG3212	peptidase
C2I05_18320	COG3212	peptidase
C2I05_18335	COG2239	Acts as a magnesium transporter
C2I05_18340	COG0789	Transcriptional regulator
C2I05_18355	COG1846	Transcriptional regulator
C2I05_18360	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2I05_18365	COG0726	polysaccharide deacetylase
C2I05_18370	COG1408	metallophosphoesterase
C2I05_18380	COG0463	Glycosyl transferase, family 2
C2I05_18385	COG1793	dna ligase
C2I05_18385	COG3285	dna ligase
C2I05_18390	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C2I05_18395	COG3300	MHYT domain
C2I05_18395	COG5001	Diguanylate cyclase
C2I05_18400	COG0586	Pfam SNARE associated Golgi protein
C2I05_18405	COG0861	Integral membrane protein TerC family
C2I05_18410	COG1191	sigma factor activity
C2I05_18430	COG0501	Belongs to the peptidase M48B family
C2I05_18435	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2I05_18450	COG3594	Acyltransferase
C2I05_18455	COG5002	protein histidine kinase activity
C2I05_18460	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2I05_18470	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
C2I05_18475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2I05_18480	COG0436	Aminotransferase
C2I05_18485	COG1850	ribulose-bisphosphate carboxylase activity
C2I05_18490	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
C2I05_18495	COG0235	Class ii aldolase
C2I05_18500	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C2I05_18505	COG3339	Conserved Protein
C2I05_18520	COG3852	Histidine kinase
C2I05_18525	COG1846	Transcriptional regulator
C2I05_18530	COG1360	Flagellar Motor Protein
C2I05_18535	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2I05_18540	COG0542	response to heat
C2I05_18545	COG3949	Membrane
C2I05_18550	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C2I05_18555	COG0720	synthase
C2I05_18560	COG0602	queuosine metabolic process
C2I05_18565	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2I05_18570	COG1733	regulation of RNA biosynthetic process
C2I05_18575	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_18580	COG4641	Protein conserved in bacteria
C2I05_18580	COG1388	LysM domain
C2I05_18585	COG1388	LysM domain
C2I05_18590	COG3858	chitin binding
C2I05_18600	COG4873	Protein conserved in bacteria
C2I05_18610	COG3773	Cell wall hydrolase
C2I05_18615	COG2244	polysaccharide biosynthetic process
C2I05_18620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2I05_18625	COG2217	Heavy metal translocating P-type atpase
C2I05_18635	COG0006	proline dipeptidase activity
C2I05_18640	COG1609	Transcriptional regulator
C2I05_18645	COG3711	transcriptional antiterminator
C2I05_18650	COG1263	PTS System
C2I05_18650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2I05_18650	COG2190	(PTS) system
C2I05_18655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I05_18660	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2I05_18670	COG1533	DNA photolyase activity
C2I05_18675	COG0456	acetyltransferase
C2I05_18680	COG0840	transmembrane signaling receptor activity
C2I05_18685	COG2084	Dehydrogenase
C2I05_18690	COG4257	antibiotic catabolic process
C2I05_18695	COG2340	Cysteine-rich secretory protein family
C2I05_18700	COG0768	penicillin binding
C2I05_18705	COG4191	Histidine kinase
C2I05_18710	COG0436	Aminotransferase
C2I05_18720	COG0784	Response regulator, receiver
C2I05_18720	COG0835	chemotaxis
C2I05_18730	COG2814	Major facilitator Superfamily
C2I05_18735	COG1376	ErfK ybiS ycfS ynhG family protein
C2I05_18740	COG1408	metallophosphoesterase
C2I05_18745	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_18750	COG2200	EAL domain
C2I05_18755	COG4703	Protein of unknown function (DUF1797)
C2I05_18760	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
C2I05_18770	COG0517	IMP dehydrogenase activity
C2I05_18775	COG0583	DNA-binding transcription factor activity
C2I05_18780	COG0716	FMN binding
C2I05_18790	COG0716	FMN binding
C2I05_18795	COG2171	N-acyltransferase activity
C2I05_18800	COG1473	amidohydrolase
C2I05_18810	COG0668	transmembrane transport
C2I05_18815	COG0450	alkyl hydroperoxide reductase
C2I05_18820	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2I05_18835	COG0746	molybdenum cofactor guanylyltransferase activity
C2I05_18840	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2I05_18845	COG0303	'Molybdopterin
C2I05_18850	COG1763	Mo-molybdopterin cofactor biosynthetic process
C2I05_18855	COG0314	molybdopterin synthase activity
C2I05_18860	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C2I05_18865	COG1132	(ABC) transporter
C2I05_18870	COG1132	(ABC) transporter
C2I05_18880	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2I05_18885	COG1136	(ABC) transporter
C2I05_18890	COG0577	efflux transmembrane transporter activity
C2I05_18895	COG1349	DNA-binding transcription factor activity
C2I05_18900	COG1105	Belongs to the carbohydrate kinase PfkB family
C2I05_18905	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2I05_18905	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2I05_18905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2I05_18910	COG0681	Belongs to the peptidase S26 family
C2I05_18920	COG0488	(ABC) transporter
C2I05_18925	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2I05_18930	COG2309	aminopeptidase activity
C2I05_18940	COG1077	Cell shape determining protein MreB Mrl
C2I05_18945	COG2002	toxin-antitoxin pair type II binding
C2I05_18950	COG3852	Histidine kinase
C2I05_18955	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C2I05_18955	COG2105	PFAM AIG2 family protein
C2I05_18960	COG0569	domain protein
C2I05_18965	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C2I05_18970	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2I05_18975	COG5503	Protein of unknown function (DUF1447)
C2I05_18980	COG0561	phosphatase activity
C2I05_18985	COG0242	peptide deformylase activity
C2I05_18995	COG0497	DNA recombination
C2I05_19000	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2I05_19005	COG0022	dehydrogenase e1 component
C2I05_19010	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2I05_19015	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2I05_19020	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2I05_19030	COG1982	Orn Lys Arg decarboxylase major
C2I05_19035	COG4476	Belongs to the UPF0223 family
C2I05_19040	COG4493	Belongs to the UPF0637 family
C2I05_19050	COG0483	inositol monophosphate 1-phosphatase activity
C2I05_19060	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C2I05_19080	COG1595	DNA-templated transcription, initiation
C2I05_19100	COG1217	gtp-binding protein TYPA
C2I05_19110	COG4896	Protein conserved in bacteria
C2I05_19120	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C2I05_19125	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2I05_19130	COG2066	Belongs to the glutaminase family
C2I05_19135	COG4838	Belongs to the UPF0358 family
C2I05_19140	COG0772	Belongs to the SEDS family
C2I05_19145	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C2I05_19150	COG1612	heme a metabolic process
C2I05_19155	COG0109	protoheme IX farnesyltransferase activity
C2I05_19160	COG2010	Cytochrome c
C2I05_19160	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2I05_19165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2I05_19170	COG1845	cytochrome c oxidase, subunit III
C2I05_19175	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2I05_19180	COG3336	cytochrome c oxidase
C2I05_19190	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C2I05_19195	COG2340	Cysteine-rich secretory protein family
C2I05_19210	COG3679	Belongs to the UPF0342 family
C2I05_19215	COG4471	UPF0298 protein
C2I05_19220	COG0742	ribosomal rna small subunit methyltransferase
C2I05_19225	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C2I05_19230	COG3314	Sporulation integral membrane protein YlbJ
C2I05_19235	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2I05_19240	COG3480	Lon protease (S16) C-terminal proteolytic domain
C2I05_19245	COG1323	Belongs to the UPF0348 family
C2I05_19255	COG1399	metal-binding, possibly nucleic acid-binding protein
C2I05_19270	COG0454	-acetyltransferase
C2I05_19275	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2I05_19280	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
C2I05_19285	COG2001	Belongs to the MraZ family
C2I05_19290	COG0275	rRNA processing
C2I05_19295	COG4839	cell division protein FtsL
C2I05_19300	COG0768	penicillin binding
C2I05_19305	COG0768	penicillin binding
C2I05_19310	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2I05_19315	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2I05_19320	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2I05_19325	COG0772	Belongs to the SEDS family
C2I05_19330	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2I05_19335	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C2I05_19340	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C2I05_19345	COG3879	Bacterial protein of unknown function (DUF881)
C2I05_19350	COG3879	Bacterial protein of unknown function (DUF881)
C2I05_19355	COG3856	small basic protein
C2I05_19360	COG0849	cell division
C2I05_19365	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2I05_19370	COG4412	M6 family metalloprotease domain protein
C2I05_19370	COG1404	Belongs to the peptidase S8 family
C2I05_19380	COG1191	sigma factor activity
C2I05_19385	COG1191	sigma factor activity
C2I05_19390	COG1119	ATPase activity
C2I05_19395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2I05_19400	COG1873	PFAM PRC-barrel domain
C2I05_19405	COG1496	oxidoreductase activity
C2I05_19410	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2I05_19415	COG1799	cell septum assembly
C2I05_19420	COG0762	integral membrane protein
C2I05_19425	COG2302	S4 RNA-binding domain
C2I05_19430	COG3599	regulation of cell shape
C2I05_19435	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2I05_19440	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2I05_19445	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C2I05_19450	COG0564	pseudouridine synthase activity
C2I05_19455	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C2I05_19460	COG2233	PERMEase
C2I05_19465	COG0540	Belongs to the ATCase OTCase family
C2I05_19470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2I05_19475	COG0505	Belongs to the CarA family
C2I05_19480	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2I05_19485	COG0543	2 iron, 2 sulfur cluster binding
C2I05_19490	COG0167	dihydroorotate dehydrogenase activity
C2I05_19495	COG0284	orotidine-5'-phosphate decarboxylase activity
C2I05_19500	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C2I05_19505	COG0175	sulfate reduction
C2I05_19510	COG0306	phosphate transporter
C2I05_19515	COG2046	Belongs to the sulfate adenylyltransferase family
C2I05_19520	COG0529	Catalyzes the synthesis of activated sulfate
C2I05_19525	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2I05_19530	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
C2I05_19535	COG1648	precorrin-2 dehydrogenase activity
C2I05_19540	COG1293	RNA-binding protein homologous to eukaryotic snRNP
C2I05_19545	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C2I05_19550	COG1561	YicC-like family, N-terminal region
C2I05_19560	COG0194	GDP metabolic process
C2I05_19565	COG1758	RNA polymerase activity
C2I05_19570	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2I05_19575	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2I05_19580	COG0242	peptide deformylase activity
C2I05_19585	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2I05_19590	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2I05_19590	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2I05_19595	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C2I05_19600	COG0631	protein serine/threonine phosphatase activity
C2I05_19605	COG0515	serine threonine protein kinase
C2I05_19605	COG2815	serine threonine protein kinase
C2I05_19610	COG1162	GTPase activity
C2I05_19615	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2I05_19620	COG1564	THIamine pyrophosphokinase
C2I05_19630	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C2I05_19635	COG1302	Protein conserved in bacteria
C2I05_19640	COG1461	Dihydroxyacetone kinase
C2I05_19645	COG1760	l-serine dehydratase
C2I05_19650	COG1760	l-serine dehydratase
C2I05_19655	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2I05_19660	COG1349	DNA-binding transcription factor activity
C2I05_19660	COG2050	protein possibly involved in aromatic compounds catabolism
C2I05_19665	COG0416	fatty acid biosynthetic process
C2I05_19670	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2I05_19675	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_19690	COG1196	nuclear chromosome segregation
C2I05_19695	COG0552	protein localization to endoplasmic reticulum
C2I05_19705	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C2I05_19710	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2I05_19715	COG0228	four-way junction DNA binding
C2I05_19720	COG1837	Belongs to the UPF0109 family
C2I05_19730	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2I05_19735	COG0336	Belongs to the RNA methyltransferase TrmD family
C2I05_19740	COG0335	large ribosomal subunit rRNA binding
C2I05_19745	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2I05_19750	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2I05_19760	COG2257	FlhB HrpN YscU SpaS Family
C2I05_19765	COG0045	succinate-CoA ligase (ADP-forming) activity
C2I05_19770	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2I05_19775	COG0758	DNA mediated transformation
C2I05_19780	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2I05_19785	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C2I05_19790	COG4974	Belongs to the 'phage' integrase family
C2I05_19795	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C2I05_19800	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C2I05_19805	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C2I05_19810	COG1815	bacterial-type flagellum-dependent cell motility
C2I05_19815	COG1558	bacterial-type flagellum-dependent cell motility
C2I05_19820	COG1677	Flagellar hook-basal body complex protein FliE
C2I05_19825	COG1766	The M ring may be actively involved in energy transduction
C2I05_19830	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2I05_19835	COG1317	bacterial-type flagellum organization
C2I05_19840	COG1157	protein secretion by the type III secretion system
C2I05_19845	COG2882	bacterial-type flagellum organization
C2I05_19850	COG3334	PFAM MgtE intracellular
C2I05_19855	COG3144	bacterial-type flagellum assembly
C2I05_19860	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C2I05_19865	COG4786	Flagellar basal body rod
C2I05_19870	COG1582	Flagellar protein (FlbD)
C2I05_19875	COG1580	Controls the rotational direction of flagella during chemotaxis
C2I05_19880	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2I05_19885	COG1776	CheC inhibitor of MCP methylation
C2I05_19885	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2I05_19890	COG2201	protein-glutamate methylesterase activity
C2I05_19895	COG3190	flagellar
C2I05_19900	COG1338	Plays a role in the flagellum-specific transport system
C2I05_19905	COG1987	bacterial-type flagellum assembly
C2I05_19910	COG1684	flagellar biosynthetic protein fliR
C2I05_19915	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2I05_19920	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2I05_19925	COG1419	protein localization to endoplasmic reticulum
C2I05_19930	COG0455	bacterial-type flagellum organization
C2I05_19935	COG2201	protein-glutamate methylesterase activity
C2I05_19940	COG0643	Histidine kinase
C2I05_19940	COG2198	Histidine kinase
C2I05_19945	COG0835	chemotaxis
C2I05_19950	COG1776	CheC inhibitor of MCP methylation
C2I05_19955	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C2I05_19960	COG1191	sigma factor activity
C2I05_19970	COG0052	Belongs to the universal ribosomal protein uS2 family
C2I05_19975	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C2I05_19980	COG0528	UMP kinase activity
C2I05_19985	COG0233	cytoplasmic translational termination
C2I05_19990	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C2I05_19995	COG4589	Belongs to the CDS family
C2I05_20000	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2I05_20005	COG0750	zinc metalloprotease
C2I05_20010	COG0442	prolyl-tRNA aminoacylation
C2I05_20015	COG2176	DNA-directed DNA polymerase activity
C2I05_20020	COG0779	Required for maturation of 30S ribosomal subunits
C2I05_20025	COG0195	Participates in both transcription termination and antitermination
C2I05_20030	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C2I05_20035	COG1358	cellular component organization or biogenesis
C2I05_20040	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C2I05_20045	COG1550	Protein conserved in bacteria
C2I05_20050	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C2I05_20055	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C2I05_20060	COG0196	riboflavin kinase activity
C2I05_20065	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C2I05_20070	COG1185	polyribonucleotide nucleotidyltransferase activity
C2I05_20075	COG0726	polysaccharide deacetylase
C2I05_20080	COG0612	Peptidase, M16
C2I05_20085	COG1873	PFAM PRC-barrel domain
C2I05_20090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2I05_20095	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2I05_20100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2I05_20105	COG0527	aspartate kinase activity
C2I05_20110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2I05_20115	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2I05_20120	COG0740	serine-type endopeptidase activity
C2I05_20130	COG4980	gas vesicle protein
C2I05_20130	COG1674	ftsk spoiiie
C2I05_20135	COG2188	Transcriptional regulator
C2I05_20140	COG2814	Major facilitator Superfamily
C2I05_20145	COG0612	Peptidase, M16
C2I05_20150	COG0612	Peptidase, M16
C2I05_20155	COG0300	oxidoreductase activity
C2I05_20170	COG1426	Protein conserved in bacteria
C2I05_20175	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2I05_20180	COG1058	Belongs to the CinA family
C2I05_20180	COG1546	Belongs to the CinA family
C2I05_20185	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C2I05_20190	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2I05_20195	COG1418	mRNA catabolic process
C2I05_20200	COG1692	metallophosphoesterase
C2I05_20205	COG2359	stage V sporulation protein S
C2I05_20210	COG1063	alcohol dehydrogenase
C2I05_20215	COG0156	8-amino-7-oxononanoate synthase activity
C2I05_20220	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2I05_20225	COG4550	Control of competence regulator ComK, YlbF/YmcA
C2I05_20235	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C2I05_20240	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2I05_20255	COG3226	Transcriptional regulator
C2I05_20260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I05_20270	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2I05_20275	COG3321	synthase
C2I05_20280	COG2070	2-Nitropropane dioxygenase
C2I05_20280	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2I05_20285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2I05_20290	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2I05_20295	COG3425	synthase
C2I05_20300	COG1024	Enoyl-CoA hydratase
C2I05_20305	COG1024	Enoyl-CoA hydratase
C2I05_20310	COG0318	PFAM AMP-dependent synthetase and ligase
C2I05_20310	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_20310	COG3321	synthase
C2I05_20310	COG0300	oxidoreductase activity
C2I05_20310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2I05_20315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2I05_20315	COG0300	oxidoreductase activity
C2I05_20315	COG3321	synthase
C2I05_20315	COG4221	oxidoreductase activity
C2I05_20320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2I05_20320	COG3321	synthase
C2I05_20320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2I05_20320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2I05_20320	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_20325	COG4221	oxidoreductase activity
C2I05_20325	COG3321	synthase
C2I05_20325	COG1028	Short-chain dehydrogenase reductase Sdr
C2I05_20325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2I05_20330	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2I05_20330	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2I05_20330	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C2I05_20330	COG3321	synthase
C2I05_20335	COG2124	cytochrome p450
C2I05_20345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2I05_20350	COG1404	Belongs to the peptidase S8 family
C2I05_20360	COG4195	phage-related replication protein
C2I05_20365	COG1764	response to oxidative stress
C2I05_20370	COG2076	Multidrug Resistance protein
C2I05_20375	COG2076	Multidrug Resistance protein
C2I05_20390	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C2I05_20395	COG1923	regulation of RNA biosynthetic process
C2I05_20410	COG1780	Probably involved in ribonucleotide reductase function
C2I05_20415	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2I05_20420	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2I05_20425	COG4112	unkown
C2I05_20430	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2I05_20440	COG0464	growth
C2I05_20445	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2I05_20450	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
C2I05_20455	COG0789	Transcriptional regulator
C2I05_20460	COG0174	glutamine synthetase
C2I05_20465	COG4974	Belongs to the 'phage' integrase family
C2I05_20545	COG0582	viral genome integration into host DNA
C2I05_20660	COG3942	CHAP domain
C2I05_20660	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2I05_20690	COG4824	toxin secretion phage lysis holin
C2I05_20695	COG3409	Peptidoglycan-binding domain 1 protein
C2I05_20695	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2I05_20695	COG1388	LysM domain
C2I05_20705	COG5444	nuclease activity
C2I05_20745	COG0463	Glycosyl transferase, family 2
C2I05_20800	COG0135	phosphoribosylanthranilate isomerase activity
C2I05_20805	COG2211	Major facilitator Superfamily
C2I05_20810	COG3507	Belongs to the glycosyl hydrolase 43 family
C2I05_20815	COG1940	carbohydrate kinase activity
C2I05_20820	COG2115	Belongs to the xylose isomerase family
C2I05_20825	COG1070	Carbohydrate kinase
C2I05_20835	COG1525	nuclease
C2I05_20840	COG2814	Major facilitator Superfamily
C2I05_20845	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2I05_20860	COG0756	dUTP diphosphatase activity
C2I05_20900	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2I05_20910	COG3832	glyoxalase III activity
C2I05_20920	COG0697	spore germination
C2I05_20925	COG0531	amino acid
C2I05_20955	COG4195	phage-related replication protein
C2I05_20965	COG0346	lactoylglutathione lyase activity
C2I05_20975	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2I05_20980	COG1388	LysM domain
C2I05_20985	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2I05_20990	COG4224	UPF0291 protein
C2I05_20995	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2I05_21005	COG3763	UPF0154 protein
C2I05_21015	COG0785	Cytochrome C biogenesis protein
C2I05_21020	COG2201	protein-glutamate methylesterase activity
C2I05_21025	COG4846	Membrane protein involved in cytochrome C biogenesis
C2I05_21035	COG0071	Belongs to the small heat shock protein (HSP20) family
C2I05_21050	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2I05_21055	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2I05_21075	COG0824	Thioesterase
C2I05_21085	COG4841	protein insertion into membrane
C2I05_21090	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C2I05_21095	COG1832	CoA-binding protein
C2I05_21100	COG0187	DNA topoisomerase II activity
C2I05_21105	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2I05_21115	COG1115	amino acid carrier protein
C2I05_21120	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C2I05_21130	COG5520	Belongs to the glycosyl hydrolase 30 family
C2I05_21135	COG3507	Belongs to the glycosyl hydrolase 43 family
C2I05_21140	COG2246	polysaccharide biosynthetic process
C2I05_21145	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2I05_21150	COG0586	Pfam SNARE associated Golgi protein
C2I05_21155	COG2404	hydrolase activity, acting on ester bonds
C2I05_21160	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2I05_21165	COG1024	Enoyl-CoA hydratase
C2I05_21170	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2I05_21175	COG0511	ligase activity, forming carbon-carbon bonds
C2I05_21180	COG0439	Biotin carboxylase
C2I05_21185	COG0318	PFAM AMP-dependent synthetase and ligase
C2I05_21190	COG1960	acyl-CoA dehydrogenase activity
C2I05_21195	COG1649	PFAM Uncharacterised BCR, COG1649
C2I05_21205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2I05_21205	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C2I05_21210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2I05_21215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2I05_21220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2I05_21225	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2I05_21230	COG2027	D-alanyl-D-alanine carboxypeptidase
C2I05_21235	COG2017	converts alpha-aldose to the beta-anomer
C2I05_21240	COG0534	Mate efflux family protein
C2I05_21255	COG0582	viral genome integration into host DNA
C2I05_21260	COG0166	Belongs to the GPI family
C2I05_21265	COG0405	Gamma-glutamyltransferase
C2I05_21270	COG0583	DNA-binding transcription factor activity
C2I05_21275	COG0604	alcohol dehydrogenase
C2I05_21280	COG0493	'glutamate synthase
C2I05_21285	COG0067	glutamate synthase
C2I05_21285	COG0069	glutamate synthase activity
C2I05_21285	COG0070	glutamate synthase
C2I05_21290	COG0583	DNA-binding transcription factor activity
C2I05_21295	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C2I05_21300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2I05_21310	COG0300	oxidoreductase activity
C2I05_21315	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
C2I05_21325	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2I05_21330	COG2814	Major facilitator Superfamily
C2I05_21335	COG1070	Carbohydrate kinase
C2I05_21340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2I05_21345	COG0243	molybdopterin cofactor binding
C2I05_21370	COG0840	transmembrane signaling receptor activity
C2I05_21370	COG5278	phosphoserine phosphatase activity