locus-tag	class	description
C2H91_00005	COG0583	DNA-binding transcription factor activity
C2H91_00010	COG0405	Gamma-glutamyltransferase
C2H91_00015	COG0166	Belongs to the GPI family
C2H91_00020	COG0582	viral genome integration into host DNA
C2H91_00115	COG0582	viral genome integration into host DNA
C2H91_00235	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2H91_00235	COG3942	CHAP domain
C2H91_00275	COG1388	LysM domain
C2H91_00275	COG3409	Peptidoglycan-binding domain 1 protein
C2H91_00275	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2H91_00290	COG5444	nuclease activity
C2H91_00305	COG0534	Mate efflux family protein
C2H91_00310	COG2017	converts alpha-aldose to the beta-anomer
C2H91_00315	COG2027	D-alanyl-D-alanine carboxypeptidase
C2H91_00320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H91_00325	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H91_00330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H91_00335	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H91_00340	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H91_00340	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C2H91_00350	COG1649	PFAM Uncharacterised BCR, COG1649
C2H91_00360	COG1960	acyl-CoA dehydrogenase activity
C2H91_00365	COG0318	PFAM AMP-dependent synthetase and ligase
C2H91_00370	COG0439	Biotin carboxylase
C2H91_00375	COG0511	ligase activity, forming carbon-carbon bonds
C2H91_00380	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2H91_00385	COG1024	Enoyl-CoA hydratase
C2H91_00390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2H91_00395	COG2404	hydrolase activity, acting on ester bonds
C2H91_00400	COG0586	Pfam SNARE associated Golgi protein
C2H91_00405	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2H91_00410	COG2246	polysaccharide biosynthetic process
C2H91_00415	COG3507	Belongs to the glycosyl hydrolase 43 family
C2H91_00420	COG5520	Belongs to the glycosyl hydrolase 30 family
C2H91_00430	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C2H91_00435	COG1115	amino acid carrier protein
C2H91_00445	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2H91_00450	COG0187	DNA topoisomerase II activity
C2H91_00455	COG1832	CoA-binding protein
C2H91_00460	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C2H91_00465	COG4841	protein insertion into membrane
C2H91_00475	COG0824	Thioesterase
C2H91_00495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H91_00500	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2H91_00515	COG0071	Belongs to the small heat shock protein (HSP20) family
C2H91_00525	COG4846	Membrane protein involved in cytochrome C biogenesis
C2H91_00530	COG2201	protein-glutamate methylesterase activity
C2H91_00535	COG0785	Cytochrome C biogenesis protein
C2H91_00545	COG3763	UPF0154 protein
C2H91_00555	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2H91_00560	COG4224	UPF0291 protein
C2H91_00565	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2H91_00570	COG1388	LysM domain
C2H91_00575	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2H91_00585	COG0346	lactoylglutathione lyase activity
C2H91_00595	COG4195	phage-related replication protein
C2H91_00625	COG0531	amino acid
C2H91_00630	COG0697	spore germination
C2H91_00640	COG3832	glyoxalase III activity
C2H91_00650	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2H91_00685	COG0756	dUTP diphosphatase activity
C2H91_00695	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2H91_00700	COG2814	Major facilitator Superfamily
C2H91_00705	COG1525	nuclease
C2H91_00715	COG1070	Carbohydrate kinase
C2H91_00720	COG2115	Belongs to the xylose isomerase family
C2H91_00725	COG1940	carbohydrate kinase activity
C2H91_00730	COG3507	Belongs to the glycosyl hydrolase 43 family
C2H91_00735	COG2211	Major facilitator Superfamily
C2H91_00740	COG0135	phosphoribosylanthranilate isomerase activity
C2H91_00765	COG3655	Transcriptional regulator
C2H91_00780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H91_00790	COG0463	Glycosyl transferase, family 2
C2H91_00830	COG5444	nuclease activity
C2H91_00850	COG0174	glutamine synthetase
C2H91_00855	COG0789	Transcriptional regulator
C2H91_00860	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
C2H91_00865	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2H91_00870	COG0464	growth
C2H91_00880	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H91_00885	COG4112	unkown
C2H91_00890	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2H91_00895	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2H91_00900	COG1780	Probably involved in ribonucleotide reductase function
C2H91_00915	COG1923	regulation of RNA biosynthetic process
C2H91_00920	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C2H91_00935	COG2076	Multidrug Resistance protein
C2H91_00940	COG2076	Multidrug Resistance protein
C2H91_00945	COG1764	response to oxidative stress
C2H91_00950	COG4195	phage-related replication protein
C2H91_00960	COG1404	Belongs to the peptidase S8 family
C2H91_00965	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H91_00975	COG2124	cytochrome p450
C2H91_00980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H91_00980	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2H91_00980	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C2H91_00980	COG3321	synthase
C2H91_00985	COG4221	oxidoreductase activity
C2H91_00985	COG3321	synthase
C2H91_00985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H91_00985	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_00990	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_00990	COG3321	synthase
C2H91_00990	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H91_00990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H91_00990	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H91_00995	COG4221	oxidoreductase activity
C2H91_00995	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H91_00995	COG0300	oxidoreductase activity
C2H91_00995	COG3321	synthase
C2H91_01000	COG3321	synthase
C2H91_01000	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_01000	COG0300	oxidoreductase activity
C2H91_01000	COG0318	PFAM AMP-dependent synthetase and ligase
C2H91_01000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H91_01005	COG1024	Enoyl-CoA hydratase
C2H91_01010	COG1024	Enoyl-CoA hydratase
C2H91_01015	COG3425	synthase
C2H91_01020	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2H91_01025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H91_01030	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2H91_01030	COG2070	2-Nitropropane dioxygenase
C2H91_01035	COG3321	synthase
C2H91_01040	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2H91_01050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H91_01055	COG3226	Transcriptional regulator
C2H91_01070	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2H91_01075	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C2H91_01085	COG4550	Control of competence regulator ComK, YlbF/YmcA
C2H91_01090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2H91_01095	COG0156	8-amino-7-oxononanoate synthase activity
C2H91_01100	COG1063	alcohol dehydrogenase
C2H91_01105	COG2359	stage V sporulation protein S
C2H91_01110	COG1692	metallophosphoesterase
C2H91_01115	COG1418	mRNA catabolic process
C2H91_01120	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2H91_01125	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C2H91_01130	COG1546	Belongs to the CinA family
C2H91_01130	COG1058	Belongs to the CinA family
C2H91_01135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2H91_01140	COG1426	Protein conserved in bacteria
C2H91_01155	COG0300	oxidoreductase activity
C2H91_01160	COG0612	Peptidase, M16
C2H91_01165	COG0612	Peptidase, M16
C2H91_01170	COG2814	Major facilitator Superfamily
C2H91_01175	COG2188	Transcriptional regulator
C2H91_01180	COG1674	ftsk spoiiie
C2H91_01180	COG4980	gas vesicle protein
C2H91_01190	COG0740	serine-type endopeptidase activity
C2H91_01195	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2H91_01200	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2H91_01205	COG0527	aspartate kinase activity
C2H91_01210	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2H91_01215	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2H91_01220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2H91_01225	COG1873	PFAM PRC-barrel domain
C2H91_01230	COG0612	Peptidase, M16
C2H91_01235	COG0726	polysaccharide deacetylase
C2H91_01240	COG1185	polyribonucleotide nucleotidyltransferase activity
C2H91_01245	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C2H91_01250	COG0196	riboflavin kinase activity
C2H91_01255	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C2H91_01260	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C2H91_01265	COG1550	Protein conserved in bacteria
C2H91_01275	COG1358	cellular component organization or biogenesis
C2H91_01280	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C2H91_01285	COG0195	Participates in both transcription termination and antitermination
C2H91_01290	COG0779	Required for maturation of 30S ribosomal subunits
C2H91_01295	COG2176	DNA-directed DNA polymerase activity
C2H91_01300	COG0442	prolyl-tRNA aminoacylation
C2H91_01305	COG0750	zinc metalloprotease
C2H91_01310	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2H91_01315	COG4589	Belongs to the CDS family
C2H91_01320	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C2H91_01325	COG0233	cytoplasmic translational termination
C2H91_01330	COG0528	UMP kinase activity
C2H91_01335	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C2H91_01340	COG0052	Belongs to the universal ribosomal protein uS2 family
C2H91_01350	COG1191	sigma factor activity
C2H91_01355	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C2H91_01360	COG1776	CheC inhibitor of MCP methylation
C2H91_01365	COG0835	chemotaxis
C2H91_01370	COG2198	Histidine kinase
C2H91_01370	COG0643	Histidine kinase
C2H91_01375	COG2201	protein-glutamate methylesterase activity
C2H91_01380	COG0455	bacterial-type flagellum organization
C2H91_01385	COG1419	protein localization to endoplasmic reticulum
C2H91_01390	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2H91_01395	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2H91_01400	COG1684	flagellar biosynthetic protein fliR
C2H91_01405	COG1987	bacterial-type flagellum assembly
C2H91_01410	COG1338	Plays a role in the flagellum-specific transport system
C2H91_01415	COG3190	flagellar
C2H91_01420	COG2201	protein-glutamate methylesterase activity
C2H91_01425	COG1776	CheC inhibitor of MCP methylation
C2H91_01425	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2H91_01430	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2H91_01435	COG1580	Controls the rotational direction of flagella during chemotaxis
C2H91_01440	COG1582	Flagellar protein (FlbD)
C2H91_01445	COG4786	Flagellar basal body rod
C2H91_01450	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C2H91_01455	COG3144	bacterial-type flagellum assembly
C2H91_01460	COG3334	PFAM MgtE intracellular
C2H91_01465	COG2882	bacterial-type flagellum organization
C2H91_01470	COG1157	protein secretion by the type III secretion system
C2H91_01475	COG1317	bacterial-type flagellum organization
C2H91_01480	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2H91_01485	COG1766	The M ring may be actively involved in energy transduction
C2H91_01490	COG1677	Flagellar hook-basal body complex protein FliE
C2H91_01495	COG1558	bacterial-type flagellum-dependent cell motility
C2H91_01500	COG1815	bacterial-type flagellum-dependent cell motility
C2H91_01505	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C2H91_01510	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C2H91_01515	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C2H91_01520	COG4974	Belongs to the 'phage' integrase family
C2H91_01525	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C2H91_01530	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2H91_01535	COG0758	DNA mediated transformation
C2H91_01540	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2H91_01545	COG0045	succinate-CoA ligase (ADP-forming) activity
C2H91_01550	COG2257	FlhB HrpN YscU SpaS Family
C2H91_01560	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2H91_01565	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2H91_01570	COG0335	large ribosomal subunit rRNA binding
C2H91_01575	COG0336	Belongs to the RNA methyltransferase TrmD family
C2H91_01580	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2H91_01590	COG1837	Belongs to the UPF0109 family
C2H91_01595	COG0228	four-way junction DNA binding
C2H91_01600	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2H91_01605	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C2H91_01615	COG0552	protein localization to endoplasmic reticulum
C2H91_01620	COG1196	nuclear chromosome segregation
C2H91_01625	COG0571	ribonuclease III activity
C2H91_01635	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_01640	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2H91_01645	COG0416	fatty acid biosynthetic process
C2H91_01650	COG1349	DNA-binding transcription factor activity
C2H91_01650	COG2050	protein possibly involved in aromatic compounds catabolism
C2H91_01655	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2H91_01660	COG1760	l-serine dehydratase
C2H91_01665	COG1760	l-serine dehydratase
C2H91_01670	COG1461	Dihydroxyacetone kinase
C2H91_01675	COG1302	Protein conserved in bacteria
C2H91_01680	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C2H91_01690	COG1564	THIamine pyrophosphokinase
C2H91_01695	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2H91_01700	COG1162	GTPase activity
C2H91_01705	COG0515	serine threonine protein kinase
C2H91_01705	COG2815	serine threonine protein kinase
C2H91_01710	COG0631	protein serine/threonine phosphatase activity
C2H91_01715	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C2H91_01720	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2H91_01720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2H91_01725	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2H91_01730	COG0242	peptide deformylase activity
C2H91_01735	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2H91_01740	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2H91_01745	COG1758	RNA polymerase activity
C2H91_01750	COG0194	GDP metabolic process
C2H91_01760	COG1561	YicC-like family, N-terminal region
C2H91_01765	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C2H91_01770	COG1293	RNA-binding protein homologous to eukaryotic snRNP
C2H91_01775	COG1648	precorrin-2 dehydrogenase activity
C2H91_01780	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
C2H91_01785	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2H91_01790	COG0529	Catalyzes the synthesis of activated sulfate
C2H91_01795	COG2046	Belongs to the sulfate adenylyltransferase family
C2H91_01800	COG0306	phosphate transporter
C2H91_01805	COG0175	sulfate reduction
C2H91_01810	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C2H91_01815	COG0284	orotidine-5'-phosphate decarboxylase activity
C2H91_01820	COG0167	dihydroorotate dehydrogenase activity
C2H91_01825	COG0543	2 iron, 2 sulfur cluster binding
C2H91_01830	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2H91_01835	COG0505	Belongs to the CarA family
C2H91_01840	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2H91_01845	COG0540	Belongs to the ATCase OTCase family
C2H91_01850	COG2233	PERMEase
C2H91_01855	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C2H91_01860	COG0564	pseudouridine synthase activity
C2H91_01865	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C2H91_01870	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2H91_01875	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2H91_01880	COG3599	regulation of cell shape
C2H91_01885	COG2302	S4 RNA-binding domain
C2H91_01890	COG0762	integral membrane protein
C2H91_01895	COG1799	cell septum assembly
C2H91_01900	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2H91_01905	COG1496	oxidoreductase activity
C2H91_01910	COG1873	PFAM PRC-barrel domain
C2H91_01915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2H91_01920	COG1119	ATPase activity
C2H91_01925	COG1191	sigma factor activity
C2H91_01930	COG1191	sigma factor activity
C2H91_01940	COG4412	M6 family metalloprotease domain protein
C2H91_01940	COG1404	Belongs to the peptidase S8 family
C2H91_01945	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2H91_01950	COG0849	cell division
C2H91_01955	COG3856	small basic protein
C2H91_01960	COG3879	Bacterial protein of unknown function (DUF881)
C2H91_01965	COG3879	Bacterial protein of unknown function (DUF881)
C2H91_01970	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C2H91_01975	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C2H91_01980	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2H91_01985	COG0772	Belongs to the SEDS family
C2H91_01990	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2H91_01995	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2H91_02000	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2H91_02005	COG0768	penicillin binding
C2H91_02010	COG0768	penicillin binding
C2H91_02015	COG4839	cell division protein FtsL
C2H91_02020	COG0275	rRNA processing
C2H91_02025	COG2001	Belongs to the MraZ family
C2H91_02030	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
C2H91_02035	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2H91_02040	COG0454	-acetyltransferase
C2H91_02055	COG1399	metal-binding, possibly nucleic acid-binding protein
C2H91_02065	COG1323	Belongs to the UPF0348 family
C2H91_02070	COG3480	Lon protease (S16) C-terminal proteolytic domain
C2H91_02075	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2H91_02080	COG3314	Sporulation integral membrane protein YlbJ
C2H91_02085	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C2H91_02090	COG0742	ribosomal rna small subunit methyltransferase
C2H91_02095	COG4471	UPF0298 protein
C2H91_02100	COG3679	Belongs to the UPF0342 family
C2H91_02115	COG2340	Cysteine-rich secretory protein family
C2H91_02120	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C2H91_02130	COG3336	cytochrome c oxidase
C2H91_02135	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2H91_02140	COG1845	cytochrome c oxidase, subunit III
C2H91_02145	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2H91_02150	COG2010	Cytochrome c
C2H91_02150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2H91_02155	COG0109	protoheme IX farnesyltransferase activity
C2H91_02160	COG1612	heme a metabolic process
C2H91_02165	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C2H91_02170	COG0772	Belongs to the SEDS family
C2H91_02175	COG4838	Belongs to the UPF0358 family
C2H91_02180	COG2066	Belongs to the glutaminase family
C2H91_02185	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2H91_02190	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C2H91_02200	COG4896	Protein conserved in bacteria
C2H91_02210	COG1217	gtp-binding protein TYPA
C2H91_02230	COG1595	DNA-templated transcription, initiation
C2H91_02250	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C2H91_02260	COG0483	inositol monophosphate 1-phosphatase activity
C2H91_02270	COG4493	Belongs to the UPF0637 family
C2H91_02275	COG4476	Belongs to the UPF0223 family
C2H91_02280	COG1982	Orn Lys Arg decarboxylase major
C2H91_02290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H91_02295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2H91_02300	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H91_02305	COG0022	dehydrogenase e1 component
C2H91_02310	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2H91_02315	COG0497	DNA recombination
C2H91_02325	COG0242	peptide deformylase activity
C2H91_02330	COG0561	phosphatase activity
C2H91_02335	COG5503	Protein of unknown function (DUF1447)
C2H91_02340	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2H91_02345	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C2H91_02350	COG0569	domain protein
C2H91_02355	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C2H91_02355	COG2105	PFAM AIG2 family protein
C2H91_02360	COG3852	Histidine kinase
C2H91_02365	COG2002	toxin-antitoxin pair type II binding
C2H91_02370	COG1077	Cell shape determining protein MreB Mrl
C2H91_02380	COG2309	aminopeptidase activity
C2H91_02385	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2H91_02390	COG0488	(ABC) transporter
C2H91_02400	COG0681	Belongs to the peptidase S26 family
C2H91_02405	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H91_02405	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H91_02405	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H91_02410	COG1105	Belongs to the carbohydrate kinase PfkB family
C2H91_02415	COG1349	DNA-binding transcription factor activity
C2H91_02420	COG0577	efflux transmembrane transporter activity
C2H91_02425	COG1136	(ABC) transporter
C2H91_02430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2H91_02440	COG1132	(ABC) transporter
C2H91_02445	COG1132	(ABC) transporter
C2H91_02450	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C2H91_02455	COG0314	molybdopterin synthase activity
C2H91_02460	COG1763	Mo-molybdopterin cofactor biosynthetic process
C2H91_02465	COG0303	'Molybdopterin
C2H91_02470	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2H91_02475	COG0746	molybdenum cofactor guanylyltransferase activity
C2H91_02490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H91_02495	COG0450	alkyl hydroperoxide reductase
C2H91_02500	COG0668	transmembrane transport
C2H91_02510	COG1473	amidohydrolase
C2H91_02515	COG2171	N-acyltransferase activity
C2H91_02520	COG0716	FMN binding
C2H91_02530	COG0716	FMN binding
C2H91_02535	COG0583	DNA-binding transcription factor activity
C2H91_02540	COG0517	IMP dehydrogenase activity
C2H91_02550	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
C2H91_02555	COG4703	Protein of unknown function (DUF1797)
C2H91_02560	COG2200	EAL domain
C2H91_02565	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_02570	COG1408	metallophosphoesterase
C2H91_02575	COG1376	ErfK ybiS ycfS ynhG family protein
C2H91_02580	COG2814	Major facilitator Superfamily
C2H91_02590	COG0835	chemotaxis
C2H91_02590	COG0784	Response regulator, receiver
C2H91_02600	COG0436	Aminotransferase
C2H91_02605	COG4191	Histidine kinase
C2H91_02610	COG0768	penicillin binding
C2H91_02615	COG2340	Cysteine-rich secretory protein family
C2H91_02620	COG4257	antibiotic catabolic process
C2H91_02625	COG2084	Dehydrogenase
C2H91_02630	COG0840	transmembrane signaling receptor activity
C2H91_02640	COG1533	DNA photolyase activity
C2H91_02650	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2H91_02655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H91_02660	COG2190	(PTS) system
C2H91_02660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H91_02660	COG1263	PTS System
C2H91_02665	COG3711	transcriptional antiterminator
C2H91_02670	COG1609	Transcriptional regulator
C2H91_02675	COG0006	proline dipeptidase activity
C2H91_02685	COG2217	Heavy metal translocating P-type atpase
C2H91_02690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H91_02695	COG2244	polysaccharide biosynthetic process
C2H91_02700	COG3773	Cell wall hydrolase
C2H91_02710	COG4873	Protein conserved in bacteria
C2H91_02720	COG3858	chitin binding
C2H91_02725	COG1388	LysM domain
C2H91_02730	COG1388	LysM domain
C2H91_02730	COG4641	Protein conserved in bacteria
C2H91_02735	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_02740	COG1733	regulation of RNA biosynthetic process
C2H91_02745	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2H91_02750	COG0602	queuosine metabolic process
C2H91_02755	COG0720	synthase
C2H91_02760	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C2H91_02765	COG3949	Membrane
C2H91_02770	COG0542	response to heat
C2H91_02775	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2H91_02780	COG1360	Flagellar Motor Protein
C2H91_02785	COG1846	Transcriptional regulator
C2H91_02790	COG3852	Histidine kinase
C2H91_02805	COG3339	Conserved Protein
C2H91_02810	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C2H91_02815	COG0235	Class ii aldolase
C2H91_02820	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
C2H91_02825	COG1850	ribulose-bisphosphate carboxylase activity
C2H91_02830	COG0436	Aminotransferase
C2H91_02835	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2H91_02840	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
C2H91_02845	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C2H91_02850	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2H91_02855	COG5002	protein histidine kinase activity
C2H91_02860	COG3594	Acyltransferase
C2H91_02875	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2H91_02880	COG0501	Belongs to the peptidase M48B family
C2H91_02900	COG1191	sigma factor activity
C2H91_02905	COG0861	Integral membrane protein TerC family
C2H91_02910	COG0586	Pfam SNARE associated Golgi protein
C2H91_02915	COG5001	Diguanylate cyclase
C2H91_02915	COG3300	MHYT domain
C2H91_02920	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C2H91_02925	COG1793	dna ligase
C2H91_02925	COG3285	dna ligase
C2H91_02930	COG0463	Glycosyl transferase, family 2
C2H91_02940	COG1408	metallophosphoesterase
C2H91_02945	COG0726	polysaccharide deacetylase
C2H91_02950	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2H91_02955	COG1846	Transcriptional regulator
C2H91_02970	COG0789	Transcriptional regulator
C2H91_02975	COG2239	Acts as a magnesium transporter
C2H91_02990	COG3212	peptidase
C2H91_02995	COG3212	peptidase
C2H91_03000	COG5002	protein histidine kinase activity
C2H91_03000	COG3850	Histidine kinase
C2H91_03005	COG0745	RESPONSE REGULATOR receiver
C2H91_03015	COG4721	ABC-type cobalt transport system, permease component
C2H91_03020	COG1122	ATPase activity
C2H91_03025	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C2H91_03030	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H91_03035	COG1404	Belongs to the peptidase S8 family
C2H91_03040	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2H91_03050	COG0590	tRNA wobble adenosine to inosine editing
C2H91_03060	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H91_03065	COG2814	Major facilitator Superfamily
C2H91_03080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H91_03115	COG1764	response to oxidative stress
C2H91_03120	COG1846	Transcriptional regulator
C2H91_03125	COG1764	response to oxidative stress
C2H91_03130	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C2H91_03135	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C2H91_03140	COG0788	formyltetrahydrofolate deformylase activity
C2H91_03145	COG2076	Multidrug Resistance protein
C2H91_03150	COG2076	Multidrug Resistance protein
C2H91_03155	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H91_03160	COG2318	DinB family
C2H91_03165	COG2323	membrane
C2H91_03175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2H91_03175	COG1017	nitric oxide dioxygenase activity
C2H91_03180	COG1607	acyl-coa hydrolase
C2H91_03185	COG1834	amidinotransferase
C2H91_03190	COG2706	6-phosphogluconolactonase activity
C2H91_03195	COG4608	Belongs to the ABC transporter superfamily
C2H91_03200	COG0791	NLP P60 protein
C2H91_03205	COG4948	Mandelate Racemase Muconate Lactonizing
C2H91_03210	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2H91_03215	COG4166	transmembrane transport
C2H91_03220	COG0444	Belongs to the ABC transporter superfamily
C2H91_03225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2H91_03230	COG0601	transmembrane transport
C2H91_03235	COG2362	D-Aminopeptidase
C2H91_03240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2H91_03245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H91_03250	COG0463	Glycosyl transferase, family 2
C2H91_03255	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2H91_03260	COG0346	lactoylglutathione lyase activity
C2H91_03265	COG0531	amino acid
C2H91_03270	COG1392	Phosphate transport regulator
C2H91_03275	COG0306	phosphate transporter
C2H91_03290	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2H91_03290	COG3409	Peptidoglycan-binding domain 1 protein
C2H91_03330	COG3778	Protein conserved in bacteria
C2H91_03335	COG3299	homolog of phage Mu protein gp47
C2H91_03340	COG3628	GPW Gp25 family protein
C2H91_03350	COG4193	domain, Protein
C2H91_03355	COG1652	LysM domain
C2H91_03360	COG3953	SLT domain
C2H91_03360	COG5412	phage tail tape measure protein
C2H91_03410	COG4653	Phage capsid family
C2H91_03415	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C2H91_03420	COG5518	Phage portal protein
C2H91_03425	COG1783	phage Terminase large subunit
C2H91_03430	COG5484	DNA packaging
C2H91_03430	COG3728	DNA packaging
C2H91_03435	COG1595	DNA-templated transcription, initiation
C2H91_03455	COG1484	DNA-dependent DNA replication
C2H91_03460	COG1522	sequence-specific DNA binding
C2H91_03470	COG1396	sequence-specific DNA binding
C2H91_03475	COG2856	Zn peptidase
C2H91_03480	COG3546	catalase activity
C2H91_03485	COG4195	phage-related replication protein
C2H91_03495	COG1388	LysM domain
C2H91_03495	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2H91_03495	COG3409	Peptidoglycan-binding domain 1 protein
C2H91_03500	COG2350	Protein conserved in bacteria
C2H91_03510	COG0457	Tetratricopeptide repeat
C2H91_03515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2H91_03520	COG2318	DinB family
C2H91_03525	COG0730	response to heat
C2H91_03530	COG2721	sulfolactate sulfo-lyase activity
C2H91_03535	COG0246	Mannitol dehydrogenase
C2H91_03540	COG1609	Transcriptional regulator
C2H91_03545	COG2271	Major facilitator Superfamily
C2H91_03550	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_03555	COG1312	Catalyzes the dehydration of D-mannonate
C2H91_03560	COG1063	alcohol dehydrogenase
C2H91_03565	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C2H91_03570	COG2211	Major facilitator Superfamily
C2H91_03575	COG1904	glucuronate isomerase
C2H91_03580	COG1252	NADH dehydrogenase
C2H91_03590	COG4297	protein containing double-stranded beta helix domain
C2H91_03595	COG0697	spore germination
C2H91_03600	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2H91_03605	COG0390	transport system, permease component
C2H91_03610	COG1587	Uroporphyrinogen-III synthase
C2H91_03620	COG1819	glycosyl
C2H91_03625	COG2124	cytochrome p450
C2H91_03635	COG1051	belongs to the nudix hydrolase family
C2H91_03645	COG2427	Protein of unknown function (DUF1641)
C2H91_03650	COG3383	formate dehydrogenase (NAD+) activity
C2H91_03660	COG2205	protein histidine kinase activity
C2H91_03665	COG5504	Zn-dependent protease
C2H91_03680	COG0726	polysaccharide deacetylase
C2H91_03690	COG0109	protoheme IX farnesyltransferase activity
C2H91_03710	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2H91_03720	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H91_03730	COG1482	cell wall glycoprotein biosynthetic process
C2H91_03735	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H91_03735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H91_03735	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H91_03740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H91_03740	COG3711	transcriptional antiterminator
C2H91_03750	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C2H91_03795	COG5505	Protein of unknown function (DUF819)
C2H91_03800	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H91_03805	COG0626	cystathionine gamma-synthase activity
C2H91_03810	COG0626	cystathionine gamma-synthase activity
C2H91_03815	COG2382	esterase
C2H91_03820	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2H91_03825	COG2153	protein acetylation
C2H91_03835	COG0210	DNA helicase
C2H91_03890	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2H91_03895	COG0351	phosphomethylpyrimidine kinase
C2H91_03900	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2H91_03905	COG2022	thiamine diphosphate biosynthetic process
C2H91_03910	COG2104	thiamine diphosphate biosynthetic process
C2H91_03915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2H91_03920	COG0352	thiamine-phosphate diphosphorylase activity
C2H91_03925	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2H91_03930	COG0569	domain protein
C2H91_03930	COG0475	glutathione-regulated potassium exporter activity
C2H91_03935	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2H91_03940	COG0564	pseudouridine synthase activity
C2H91_03945	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2H91_03950	COG2357	RelA SpoT domain protein
C2H91_03960	COG4116	CYTH
C2H91_03965	COG0741	lytic transglycosylase activity
C2H91_03970	COG2346	COG2346, Truncated hemoglobins
C2H91_03975	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C2H91_03990	COG1164	Oligoendopeptidase f
C2H91_03995	COG4469	Competence protein
C2H91_04000	COG4862	establishment of competence for transformation
C2H91_04005	COG0861	Integral membrane protein TerC family
C2H91_04010	COG1393	Belongs to the ArsC family
C2H91_04015	COG0456	acetyltransferase
C2H91_04020	COG2814	Major facilitator Superfamily
C2H91_04025	COG4608	Belongs to the ABC transporter superfamily
C2H91_04030	COG0444	Belongs to the ABC transporter superfamily
C2H91_04035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2H91_04040	COG0601	transmembrane transport
C2H91_04045	COG4166	transmembrane transport
C2H91_04050	COG0180	Tryptophanyl-tRNA synthetase
C2H91_04060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2H91_04065	COG0601	transmembrane transport
C2H91_04075	COG4608	Belongs to the ABC transporter superfamily
C2H91_04080	COG0444	Belongs to the ABC transporter superfamily
C2H91_04085	COG5504	Zn-dependent protease
C2H91_04090	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2H91_04095	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2H91_04110	COG1744	ABC transporter substrate-binding protein PnrA-like
C2H91_04120	COG2267	carboxylic ester hydrolase activity
C2H91_04135	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2H91_04140	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2H91_04145	COG0505	Belongs to the CarA family
C2H91_04150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2H91_04160	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C2H91_04165	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2H91_04170	COG2271	Major facilitator Superfamily
C2H91_04175	COG0277	FAD linked oxidase domain protein
C2H91_04185	COG2151	metal-sulfur cluster biosynthetic enzyme
C2H91_04190	COG1073	alpha beta
C2H91_04195	COG0561	phosphatase activity
C2H91_04210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H91_04215	COG1307	EDD domain protein, DegV family
C2H91_04235	COG1695	Transcriptional regulator
C2H91_04255	COG2996	Protein conserved in bacteria
C2H91_04260	COG1666	GTP binding
C2H91_04265	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C2H91_04265	COG0646	methionine synthase
C2H91_04270	COG2153	protein acetylation
C2H91_04275	COG0454	-acetyltransferase
C2H91_04280	COG2814	Major facilitator Superfamily
C2H91_04285	COG4948	Mandelate Racemase Muconate Lactonizing
C2H91_04290	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H91_04295	COG1809	phosphosulfolactate synthase activity
C2H91_04300	COG2045	Belongs to the ComB family
C2H91_04305	COG0175	sulfate reduction
C2H91_04310	COG2046	Belongs to the sulfate adenylyltransferase family
C2H91_04315	COG0529	Catalyzes the synthesis of activated sulfate
C2H91_04320	COG2267	carboxylic ester hydrolase activity
C2H91_04325	COG1357	PFAM Pentapeptide repeats (8 copies)
C2H91_04330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H91_04335	COG1279	arginine transmembrane transporter activity
C2H91_04340	COG2318	DinB family
C2H91_04345	COG0673	inositol 2-dehydrogenase activity
C2H91_04350	COG1609	Transcriptional regulator
C2H91_04355	COG1917	Cupin 2, conserved barrel domain protein
C2H91_04355	COG2207	Transcriptional regulator
C2H91_04360	COG0534	Mate efflux family protein
C2H91_04365	COG1562	ergosterol biosynthetic process
C2H91_04370	COG2318	DinB family
C2H91_04375	COG0367	asparagine synthase
C2H91_04385	COG1404	Belongs to the peptidase S8 family
C2H91_04395	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2H91_04400	COG5337	Spore coat protein CotH
C2H91_04440	COG1403	HNH endonuclease
C2H91_04445	COG0419	ATPase involved in DNA repair
C2H91_04450	COG0420	3'-5' exonuclease activity
C2H91_04455	COG1074	ATP-dependent DNA helicase activity
C2H91_04460	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C2H91_04465	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
C2H91_04475	COG4533	DNA binding
C2H91_04480	COG0477	Major facilitator Superfamily
C2H91_04480	COG2814	Major facilitator Superfamily
C2H91_04490	COG1609	Transcriptional regulator
C2H91_04495	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2H91_04500	COG0561	phosphatase activity
C2H91_04505	COG0673	inositol 2-dehydrogenase activity
C2H91_04510	COG0738	Major facilitator superfamily
C2H91_04525	COG1846	Transcriptional regulator
C2H91_04530	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2H91_04535	COG0681	Belongs to the peptidase S26 family
C2H91_04540	COG0398	Pfam SNARE associated Golgi protein
C2H91_04555	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H91_04565	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_04570	COG4903	ComK protein
C2H91_04580	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_04585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2H91_04585	COG0723	plastoquinol--plastocyanin reductase activity
C2H91_04590	COG0840	transmembrane signaling receptor activity
C2H91_04595	COG1268	BioY protein
C2H91_04600	COG0318	PFAM AMP-dependent synthetase and ligase
C2H91_04605	COG0183	Belongs to the thiolase family
C2H91_04610	COG0406	alpha-ribazole phosphatase activity
C2H91_04615	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C2H91_04620	COG0604	alcohol dehydrogenase
C2H91_04625	COG0456	acetyltransferase
C2H91_04635	COG0501	Belongs to the peptidase M48B family
C2H91_04645	COG0318	PFAM AMP-dependent synthetase and ligase
C2H91_04650	COG0702	epimerase
C2H91_04655	COG0095	Lipoate-protein ligase
C2H91_04660	COG1234	tRNA 3'-trailer cleavage
C2H91_04670	COG1301	dicarboxylic acid transport
C2H91_04675	COG4405	Protein conserved in bacteria
C2H91_04680	COG1363	Peptidase, m42
C2H91_04690	COG4377	Putative membrane peptidase family (DUF2324)
C2H91_04695	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2H91_04700	COG1511	domain protein
C2H91_04705	COG1309	transcriptional regulator
C2H91_04710	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C2H91_04715	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C2H91_04720	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C2H91_04725	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2H91_04730	COG2329	Antibiotic biosynthesis monooxygenase
C2H91_04740	COG3069	C4-dicarboxylate transmembrane transporter activity
C2H91_04745	COG1473	amidohydrolase
C2H91_04755	COG4473	ABC transporter
C2H91_04760	COG1131	(ABC) transporter
C2H91_04765	COG0537	adenosine 5'-monophosphoramidase activity
C2H91_04770	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C2H91_04785	COG4980	gas vesicle protein
C2H91_04790	COG1846	Transcriptional regulator
C2H91_04820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2H91_04830	COG3481	metal-dependent phosphohydrolase, HD sub domain
C2H91_04835	COG4717	serine-type aminopeptidase activity
C2H91_04840	COG0420	3'-5' exonuclease activity
C2H91_04845	COG1668	transmembrane transport
C2H91_04850	COG4152	abc transporter atp-binding protein
C2H91_04860	COG1024	Enoyl-CoA hydratase
C2H91_04870	COG0490	domain, Protein
C2H91_04875	COG0475	glutathione-regulated potassium exporter activity
C2H91_04880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2H91_04885	COG0561	phosphatase activity
C2H91_04890	COG4335	DNA alkylation repair
C2H91_04895	COG3679	Belongs to the UPF0342 family
C2H91_04900	COG4399	Belongs to the UPF0754 family
C2H91_04905	COG0189	ligase activity
C2H91_04910	COG0189	ligase activity
C2H91_04930	COG0702	epimerase
C2H91_04935	COG1132	(ABC) transporter
C2H91_04940	COG1132	(ABC) transporter
C2H91_04950	COG0589	response to stress
C2H91_04955	COG1757	Na H antiporter
C2H91_04960	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2H91_04965	COG0726	polysaccharide deacetylase
C2H91_04970	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2H91_04975	COG0668	transmembrane transport
C2H91_04985	COG0584	glycerophosphoryl diester phosphodiesterase
C2H91_04990	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2H91_04995	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2H91_05000	COG1253	flavin adenine dinucleotide binding
C2H91_05005	COG0436	Aminotransferase
C2H91_05010	COG0789	Transcriptional regulator
C2H91_05015	COG1253	flavin adenine dinucleotide binding
C2H91_05020	COG0204	Acyl-transferase
C2H91_05025	COG0667	Aldo Keto reductase
C2H91_05030	COG1595	DNA-templated transcription, initiation
C2H91_05045	COG0456	acetyltransferase
C2H91_05050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H91_05055	COG0733	neurotransmitter:sodium symporter activity
C2H91_05060	COG0531	amino acid
C2H91_05065	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_05070	COG0372	Belongs to the citrate synthase family
C2H91_05075	COG0583	DNA-binding transcription factor activity
C2H91_05080	COG1388	LysM domain
C2H91_05080	COG0791	NLP P60 protein
C2H91_05085	COG1785	Belongs to the alkaline phosphatase family
C2H91_05090	COG2719	SpoVR family
C2H91_05095	COG0668	transmembrane transport
C2H91_05100	COG1959	2 iron, 2 sulfur cluster binding
C2H91_05105	COG1388	LysM domain
C2H91_05105	COG0791	NLP P60 protein
C2H91_05120	COG0431	NADPH-dependent FMN reductase
C2H91_05125	COG2197	response regulator
C2H91_05130	COG4585	Histidine kinase
C2H91_05130	COG2203	Gaf domain
C2H91_05135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2H91_05140	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2H91_05145	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2H91_05150	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2H91_05155	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
C2H91_05160	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2H91_05165	COG3153	acetyltransferase
C2H91_05165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2H91_05170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2H91_05175	COG0517	IMP dehydrogenase activity
C2H91_05185	COG0564	pseudouridine synthase activity
C2H91_05190	COG3764	Sortase (surface protein transpeptidase)
C2H91_05195	COG4085	toxin activity
C2H91_05195	COG1525	nuclease
C2H91_05195	COG0737	Belongs to the 5'-nucleotidase family
C2H91_05200	COG5577	PFAM Coat F domain
C2H91_05230	COG1823	symporter activity
C2H91_05235	COG3706	GGDEF domain
C2H91_05240	COG1464	Belongs to the NlpA lipoprotein family
C2H91_05250	COG1278	Cold shock
C2H91_05255	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2H91_05260	COG1131	(ABC) transporter
C2H91_05265	COG1131	(ABC) transporter
C2H91_05270	COG1725	Transcriptional regulator
C2H91_05290	COG0655	NAD(P)H dehydrogenase (quinone) activity
C2H91_05295	COG2814	Major facilitator Superfamily
C2H91_05300	COG1566	PFAM secretion protein HlyD family protein
C2H91_05305	COG1846	Transcriptional regulator
C2H91_05310	COG2718	Belongs to the UPF0229 family
C2H91_05315	COG2766	serine protein kinase
C2H91_05320	COG1664	Polymer-forming cytoskeletal
C2H91_05325	COG1664	Polymer-forming cytoskeletal
C2H91_05330	COG0789	Transcriptional regulator
C2H91_05335	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2H91_05350	COG3382	B3 4 domain protein
C2H91_05360	COG1476	TRANSCRIPTIONal
C2H91_05370	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C2H91_05380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H91_05385	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2H91_05390	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2H91_05395	COG1116	anion transmembrane transporter activity
C2H91_05400	COG0753	catalase activity
C2H91_05415	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C2H91_05420	COG3340	Belongs to the peptidase S51 family
C2H91_05425	COG5577	PFAM Coat F domain
C2H91_05435	COG4326	sporulation control protein
C2H91_05545	COG0735	belongs to the Fur family
C2H91_05550	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2H91_05555	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2H91_05560	COG4129	membrane
C2H91_05565	COG1132	(ABC) transporter
C2H91_05570	COG3557	Belongs to the UPF0374 family
C2H91_05585	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_05595	COG1194	a g-specific adenine glycosylase
C2H91_05600	COG1988	membrane-bound metal-dependent
C2H91_05605	COG4485	Bacterial membrane protein, YfhO
C2H91_05610	COG0463	Glycosyl transferase, family 2
C2H91_05615	COG0596	Alpha beta hydrolase
C2H91_05620	COG5658	integral membrane protein
C2H91_05625	COG3103	Sh3 type 3 domain protein
C2H91_05640	COG2814	Major facilitator Superfamily
C2H91_05650	COG2137	regulation of response to DNA damage stimulus
C2H91_05655	COG1090	epimerase
C2H91_05670	COG0778	Nitroreductase
C2H91_05675	COG0384	phenazine biosynthesis protein PhzF
C2H91_05680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H91_05685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H91_05690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H91_05695	COG0392	lysyltransferase activity
C2H91_05695	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C2H91_05700	COG1846	Transcriptional regulator
C2H91_05705	COG2814	Major facilitator Superfamily
C2H91_05710	COG2318	DinB family
C2H91_05715	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
C2H91_05720	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C2H91_05725	COG1695	Transcriptional regulator
C2H91_05730	COG0842	Transport permease protein
C2H91_05735	COG1511	domain protein
C2H91_05735	COG0842	Transport permease protein
C2H91_05740	COG1131	(ABC) transporter
C2H91_05750	COG2197	response regulator
C2H91_05755	COG4585	Histidine kinase
C2H91_05760	COG2514	catechol 2,3-dioxygenase activity
C2H91_05765	COG2259	Doxx family
C2H91_05770	COG1132	(ABC) transporter
C2H91_05775	COG1132	(ABC) transporter
C2H91_05780	COG5434	Belongs to the glycosyl hydrolase 28 family
C2H91_05785	COG1263	PTS System
C2H91_05785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H91_05790	COG1737	Transcriptional regulator
C2H91_05795	COG1486	melibiose metabolic process
C2H91_05800	COG4842	Belongs to the WXG100 family
C2H91_05825	COG1742	UPF0060 membrane protein
C2H91_05835	COG3284	Transcriptional regulator
C2H91_05840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2H91_05845	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H91_05850	COG0022	dehydrogenase e1 component
C2H91_05855	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2H91_05865	COG4637	Psort location Cytoplasmic, score
C2H91_05870	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2H91_05880	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2H91_05885	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2H91_05890	COG0598	Magnesium transport protein CorA
C2H91_05895	COG2084	Dehydrogenase
C2H91_05900	COG0726	polysaccharide deacetylase
C2H91_05910	COG0535	radical SAM domain protein
C2H91_05915	COG0668	transmembrane transport
C2H91_05925	COG0387	Pfam Sodium calcium exchanger
C2H91_05930	COG0477	Major facilitator Superfamily
C2H91_05935	COG1295	ribonuclease BN
C2H91_05940	COG4980	gas vesicle protein
C2H91_05945	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2H91_05950	COG4840	Belongs to the UPF0435 family
C2H91_05955	COG2814	Major facilitator Superfamily
C2H91_05960	COG0693	protein deglycase activity
C2H91_05965	COG0737	Belongs to the 5'-nucleotidase family
C2H91_05970	COG0778	Nitroreductase
C2H91_05975	COG2188	Transcriptional regulator
C2H91_05980	COG0366	Alpha amylase catalytic
C2H91_05985	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H91_05985	COG1263	PTS System
C2H91_05990	COG0697	spore germination
C2H91_06005	COG0531	amino acid
C2H91_06010	COG1115	amino acid carrier protein
C2H91_06025	COG1368	sulfuric ester hydrolase activity
C2H91_06030	COG1263	PTS System
C2H91_06030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H91_06035	COG0024	Methionine aminopeptidase
C2H91_06055	COG2258	MOSC domain
C2H91_06060	COG1254	Belongs to the acylphosphatase family
C2H91_06065	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
C2H91_06070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H91_06075	COG2851	Citrate transporter
C2H91_06080	COG3181	Tripartite tricarboxylate transporter family receptor
C2H91_06085	COG4565	transcriptional regulatory protein
C2H91_06090	COG3290	protein histidine kinase activity
C2H91_06095	COG0471	metal ion transport
C2H91_06100	COG3866	Pectate lyase
C2H91_06120	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C2H91_06125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H91_06130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H91_06135	COG1120	ATPase activity
C2H91_06140	COG2130	NADP-dependent
C2H91_06145	COG0456	acetyltransferase
C2H91_06150	COG0513	Belongs to the DEAD box helicase family
C2H91_06155	COG0488	(ABC) transporter
C2H91_06170	COG1404	Belongs to the peptidase S8 family
C2H91_06175	COG2814	Major facilitator Superfamily
C2H91_06180	COG0789	Transcriptional regulator
C2H91_06190	COG0488	(ABC) transporter
C2H91_06195	COG0840	transmembrane signaling receptor activity
C2H91_06200	COG1012	belongs to the aldehyde dehydrogenase family
C2H91_06205	COG0531	amino acid
C2H91_06210	COG1011	Hydrolase
C2H91_06215	COG2223	nitrite transmembrane transporter activity
C2H91_06220	COG1442	glycosyl transferase family 8
C2H91_06225	COG1216	Glycosyl transferase, family 2
C2H91_06230	COG1442	glycosyl transferase family 8
C2H91_06235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H91_06240	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2H91_06245	COG1368	sulfuric ester hydrolase activity
C2H91_06250	COG2124	cytochrome p450
C2H91_06250	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2H91_06260	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2H91_06265	COG1846	Transcriptional regulator
C2H91_06270	COG0697	spore germination
C2H91_06275	COG0670	Belongs to the BI1 family
C2H91_06280	COG5583	Uncharacterized small protein (DUF2292)
C2H91_06295	COG0346	lactoylglutathione lyase activity
C2H91_06300	COG2329	Antibiotic biosynthesis monooxygenase
C2H91_06305	COG2323	membrane
C2H91_06310	COG1486	melibiose metabolic process
C2H91_06315	COG0395	ABC-type sugar transport system, permease component
C2H91_06320	COG4209	transmembrane transport
C2H91_06325	COG1653	transport
C2H91_06335	COG1874	Beta-galactosidase
C2H91_06340	COG2755	lipolytic protein G-D-S-L family
C2H91_06345	COG3401	FG-GAP repeat protein
C2H91_06350	COG3401	FG-GAP repeat protein
C2H91_06355	COG5578	integral membrane protein
C2H91_06365	COG2755	lipolytic protein G-D-S-L family
C2H91_06370	COG2207	Transcriptional regulator
C2H91_06375	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2H91_06380	COG0395	ABC-type sugar transport system, permease component
C2H91_06385	COG1175	transmembrane transport
C2H91_06390	COG1653	transport
C2H91_06395	COG4753	response regulator
C2H91_06395	COG2207	Transcriptional regulator
C2H91_06400	COG2972	Histidine kinase
C2H91_06405	COG5578	integral membrane protein
C2H91_06415	COG0454	-acetyltransferase
C2H91_06420	COG3546	catalase activity
C2H91_06435	COG0702	epimerase
C2H91_06440	COG3631	Ketosteroid isomerase-related protein
C2H91_06445	COG1309	transcriptional regulator
C2H91_06455	COG0217	transcriptional regulatory protein
C2H91_06465	COG0457	Tetratricopeptide repeat
C2H91_06485	COG3586	endonuclease activity
C2H91_06495	COG5444	nuclease activity
C2H91_06510	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
C2H91_06540	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2H91_06545	COG1597	lipid kinase activity
C2H91_06550	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2H91_06555	COG1309	transcriptional regulator
C2H91_06560	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2H91_06565	COG0154	amidase activity
C2H91_06570	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2H91_06575	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H91_06580	COG1285	pathogenesis
C2H91_06585	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H91_06590	COG4851	CamS sex pheromone cAM373 precursor
C2H91_06595	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2H91_06600	COG0210	DNA helicase
C2H91_06605	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
C2H91_06610	COG0069	glutamate synthase activity
C2H91_06615	COG4496	protein, YerC YecD
C2H91_06620	COG1470	cell adhesion involved in biofilm formation
C2H91_06625	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C2H91_06645	COG0151	Belongs to the GarS family
C2H91_06650	COG0138	bifunctional purine biosynthesis protein purh
C2H91_06655	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2H91_06660	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C2H91_06665	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2H91_06670	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2H91_06675	COG0047	phosphoribosylformylglycinamidine synthase activity
C2H91_06680	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2H91_06685	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C2H91_06690	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2H91_06695	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2H91_06700	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2H91_06710	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
C2H91_06720	COG3064	Membrane
C2H91_06725	COG2252	PERMEase
C2H91_06740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2H91_06740	COG0519	Catalyzes the synthesis of GMP from XMP
C2H91_06745	COG1305	Transglutaminase-like
C2H91_06750	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
C2H91_06755	COG0714	Associated with various cellular activities
C2H91_06760	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2H91_06770	COG1113	amino acid transport
C2H91_06775	COG2132	Multicopper oxidase
C2H91_06785	COG2267	carboxylic ester hydrolase activity
C2H91_06800	COG0823	Involved in the tonB-independent uptake of proteins
C2H91_06805	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2H91_06810	COG1063	alcohol dehydrogenase
C2H91_06815	COG2814	Major facilitator Superfamily
C2H91_06825	COG4260	virion core protein, lumpy skin disease virus
C2H91_06830	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C2H91_06835	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2H91_06840	COG1842	Phage shock protein A
C2H91_06845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H91_06850	COG2211	Major facilitator Superfamily
C2H91_06855	COG1063	alcohol dehydrogenase
C2H91_06860	COG0457	Tetratricopeptide repeat
C2H91_06865	COG1073	alpha beta
C2H91_06875	COG0459	protein refolding
C2H91_06885	COG1266	CAAX protease self-immunity
C2H91_06900	COG0805	protein transport
C2H91_06905	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2H91_06910	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C2H91_06915	COG0315	cyclic pyranopterin monophosphate synthase activity
C2H91_06920	COG0488	(ABC) transporter
C2H91_06925	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C2H91_06930	COG0456	acetyltransferase
C2H91_06935	COG1214	PFAM Peptidase M22, glycoprotease
C2H91_06940	COG0802	atpase or kinase
C2H91_06945	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C2H91_06990	COG4124	Belongs to the glycosyl hydrolase 26 family
C2H91_06995	COG1482	cell wall glycoprotein biosynthetic process
C2H91_07000	COG1940	carbohydrate kinase activity
C2H91_07005	COG2188	Transcriptional regulator
C2H91_07010	COG2723	6-phospho-beta-galactosidase activity
C2H91_07015	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H91_07020	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2H91_07025	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H91_07030	COG2814	Major facilitator Superfamily
C2H91_07035	COG1388	LysM domain
C2H91_07045	COG1078	dGTPase activity
C2H91_07050	COG0454	-acetyltransferase
C2H91_07060	COG5646	InterPro IPR014922
C2H91_07065	COG1785	Belongs to the alkaline phosphatase family
C2H91_07075	COG1819	glycosyl
C2H91_07080	COG1388	LysM domain
C2H91_07080	COG3858	chitin binding
C2H91_07085	COG1802	Transcriptional regulator
C2H91_07090	COG0730	response to heat
C2H91_07095	COG2814	Major facilitator Superfamily
C2H91_07100	COG1846	Transcriptional regulator
C2H91_07105	COG0778	Nitroreductase
C2H91_07110	COG1033	growth of symbiont in host cell
C2H91_07110	COG2409	Drug exporters of the RND superfamily
C2H91_07115	COG1846	Transcriptional regulator
C2H91_07120	COG2318	DinB family
C2H91_07125	COG1113	amino acid transport
C2H91_07130	COG0488	(ABC) transporter
C2H91_07135	COG0456	acetyltransferase
C2H91_07145	COG1309	transcriptional regulator
C2H91_07160	COG0071	Belongs to the small heat shock protein (HSP20) family
C2H91_07185	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H91_07190	COG2259	Doxx family
C2H91_07195	COG0346	lactoylglutathione lyase activity
C2H91_07200	COG0778	Nitroreductase
C2H91_07205	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2H91_07210	COG4978	Transcriptional regulator
C2H91_07210	COG0789	Transcriptional regulator
C2H91_07215	COG1811	Na channel or pump
C2H91_07220	COG2409	Drug exporters of the RND superfamily
C2H91_07225	COG2197	response regulator
C2H91_07230	COG4585	Histidine kinase
C2H91_07245	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2H91_07250	COG0640	Transcriptional regulator
C2H91_07255	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2H91_07260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H91_07265	COG0697	spore germination
C2H91_07270	COG0745	RESPONSE REGULATOR receiver
C2H91_07275	COG5002	protein histidine kinase activity
C2H91_07290	COG1316	TRANSCRIPTIONal
C2H91_07295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H91_07305	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2H91_07310	COG0640	Transcriptional regulator
C2H91_07315	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H91_07320	COG1733	regulation of RNA biosynthetic process
C2H91_07325	COG3545	Serine hydrolase
C2H91_07330	COG2030	dehydratase
C2H91_07335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H91_07340	COG0697	spore germination
C2H91_07355	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
C2H91_07365	COG0477	Major facilitator Superfamily
C2H91_07370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H91_07375	COG3708	Transcriptional regulator
C2H91_07375	COG2207	Transcriptional regulator
C2H91_07380	COG0697	spore germination
C2H91_07385	COG2207	Transcriptional regulator
C2H91_07385	COG1917	Cupin 2, conserved barrel domain protein
C2H91_07400	COG1329	Transcriptional regulator
C2H91_07405	COG1278	Cold shock
C2H91_07410	COG3239	Fatty acid desaturase
C2H91_07425	COG5444	nuclease activity
C2H91_07480	COG3091	SprT-like family
C2H91_07490	COG2183	response to ionizing radiation
C2H91_07495	COG1846	Transcriptional regulator
C2H91_07500	COG1673	EVE domain
C2H91_07510	COG2208	phosphoserine phosphatase activity
C2H91_07515	COG1191	sigma factor activity
C2H91_07520	COG2172	sigma factor antagonist activity
C2H91_07525	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H91_07530	COG2208	phosphoserine phosphatase activity
C2H91_07535	COG2172	sigma factor antagonist activity
C2H91_07540	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H91_07545	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H91_07550	COG2337	Toxic component of a toxin-antitoxin (TA) module
C2H91_07555	COG0864	Transcriptional regulator
C2H91_07560	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2H91_07565	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2H91_07570	COG0736	holo-[acyl-carrier-protein] synthase activity
C2H91_07575	COG0705	Rhomboid family
C2H91_07580	COG3428	Bacterial PH domain
C2H91_07585	COG3402	PFAM membrane-flanked domain
C2H91_07590	COG0513	Belongs to the DEAD box helicase family
C2H91_07600	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2H91_07605	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2H91_07610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H91_07615	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2H91_07630	COG1960	acyl-CoA dehydrogenase activity
C2H91_07640	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2H91_07645	COG1131	(ABC) transporter
C2H91_07650	COG0628	permease
C2H91_07655	COG1301	dicarboxylic acid transport
C2H91_07660	COG4565	transcriptional regulatory protein
C2H91_07665	COG3290	protein histidine kinase activity
C2H91_07670	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C2H91_07675	COG3546	catalase activity
C2H91_07680	COG2329	Antibiotic biosynthesis monooxygenase
C2H91_07685	COG0662	Cupin 2, conserved barrel domain protein
C2H91_07690	COG3729	General stress protein
C2H91_07695	COG2217	Heavy metal translocating P-type atpase
C2H91_07700	COG4876	unkown
C2H91_07705	COG2261	transglycosylase associated protein
C2H91_07710	COG1914	H( )-stimulated, divalent metal cation uptake system
C2H91_07740	COG0028	Belongs to the TPP enzyme family
C2H91_07745	COG0494	nUDIX hydrolase
C2H91_07750	COG0531	amino acid
C2H91_07760	COG1215	transferase activity, transferring glycosyl groups
C2H91_07765	COG5298	Protein conserved in bacteria
C2H91_07770	COG3706	GGDEF domain
C2H91_07775	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C2H91_07780	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2H91_07780	COG0551	DNA topoisomerase type I activity
C2H91_07785	COG1522	sequence-specific DNA binding
C2H91_07790	COG2814	Major facilitator Superfamily
C2H91_07800	COG3871	stress protein (general stress protein 26)
C2H91_07805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H91_07810	COG1917	Cupin 2, conserved barrel domain protein
C2H91_07815	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_07820	COG2226	methyltransferase
C2H91_07825	COG0318	PFAM AMP-dependent synthetase and ligase
C2H91_07830	COG3711	transcriptional antiterminator
C2H91_07835	COG4989	oxidoreductase activity
C2H91_07840	COG0768	penicillin binding
C2H91_07845	COG2329	Antibiotic biosynthesis monooxygenase
C2H91_07855	COG2755	lipolytic protein G-D-S-L family
C2H91_07860	COG1414	Transcriptional regulator
C2H91_07865	COG1984	allophanate hydrolase subunit 2
C2H91_07870	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C2H91_07875	COG4336	lyase activity
C2H91_07880	COG1914	H( )-stimulated, divalent metal cation uptake system
C2H91_07885	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C2H91_07890	COG0561	phosphatase activity
C2H91_07900	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2H91_07910	COG0681	Belongs to the peptidase S26 family
C2H91_07915	COG0473	3-isopropylmalate dehydrogenase activity
C2H91_07920	COG0246	Mannitol dehydrogenase
C2H91_07925	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H91_07930	COG2213	PTS system mannitol-specific
C2H91_07940	COG1349	DNA-binding transcription factor activity
C2H91_07945	COG1276	copper resistance
C2H91_07945	COG2372	response to copper ion
C2H91_07950	COG4549	nuclear export factor GLE1
C2H91_07955	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_07960	COG4975	Glucose uptake
C2H91_07965	COG1012	belongs to the aldehyde dehydrogenase family
C2H91_07970	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2H91_07975	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H91_07980	COG0640	Transcriptional regulator
C2H91_07985	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C2H91_07990	COG0778	Nitroreductase
C2H91_07995	COG1309	transcriptional regulator
C2H91_08000	COG2814	Major facilitator Superfamily
C2H91_08005	COG4607	ABC-type enterochelin transport system periplasmic component
C2H91_08010	COG4604	ABC transporter, ATP-binding protein
C2H91_08015	COG4605	iron ion homeostasis
C2H91_08020	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H91_08025	COG0527	aspartate kinase activity
C2H91_08045	COG0457	Tetratricopeptide repeat
C2H91_08050	COG5002	protein histidine kinase activity
C2H91_08050	COG3850	Histidine kinase
C2H91_08055	COG0745	RESPONSE REGULATOR receiver
C2H91_08060	COG0577	efflux transmembrane transporter activity
C2H91_08065	COG1136	(ABC) transporter
C2H91_08070	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2H91_08080	COG0697	spore germination
C2H91_08090	COG5434	Belongs to the glycosyl hydrolase 28 family
C2H91_08095	COG3104	oligopeptide transport
C2H91_08100	COG0596	Alpha beta hydrolase
C2H91_08115	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2H91_08120	COG0163	prenyltransferase activity
C2H91_08125	COG0583	DNA-binding transcription factor activity
C2H91_08130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H91_08135	COG0765	amino acid transport
C2H91_08140	COG1126	abc transporter atp-binding protein
C2H91_08145	COG2364	Membrane
C2H91_08155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H91_08160	COG0697	spore germination
C2H91_08170	COG2814	Major facilitator Superfamily
C2H91_08175	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C2H91_08180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H91_08185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H91_08190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H91_08195	COG1733	regulation of RNA biosynthetic process
C2H91_08200	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C2H91_08205	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2H91_08210	COG3290	protein histidine kinase activity
C2H91_08210	COG0840	transmembrane signaling receptor activity
C2H91_08215	COG3209	COG3209 Rhs family protein
C2H91_08225	COG2723	6-phospho-beta-galactosidase activity
C2H91_08230	COG3842	ATPase activity
C2H91_08240	COG1846	Transcriptional regulator
C2H91_08250	COG1714	RDD family
C2H91_08255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H91_08260	COG0765	amino acid transport
C2H91_08265	COG0523	cobalamin synthesis protein
C2H91_08275	COG1376	ErfK ybiS ycfS ynhG family protein
C2H91_08280	COG1469	GTP cyclohydrolase I activity
C2H91_08285	COG2223	nitrite transmembrane transporter activity
C2H91_08290	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2H91_08295	COG0243	molybdopterin cofactor binding
C2H91_08300	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2H91_08305	COG2146	nitrite reductase [NAD(P)H] activity
C2H91_08310	COG1587	Uroporphyrinogen-III synthase
C2H91_08310	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2H91_08315	COG0492	ferredoxin-NADP+ reductase activity
C2H91_08320	COG2267	carboxylic ester hydrolase activity
C2H91_08325	COG0701	Predicted permease
C2H91_08330	COG3689	TIGRFAM TIGR03943 family protein
C2H91_08350	COG2508	Transcriptional regulator
C2H91_08355	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H91_08360	COG1012	belongs to the aldehyde dehydrogenase family
C2H91_08365	COG0506	proline dehydrogenase activity
C2H91_08370	COG3541	Predicted nucleotidyltransferase
C2H91_08375	COG3458	cephalosporin-C deacetylase activity
C2H91_08380	COG0583	DNA-binding transcription factor activity
C2H91_08385	COG2226	methyltransferase
C2H91_08390	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2H91_08395	COG1660	Displays ATPase and GTPase activities
C2H91_08400	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C2H91_08405	COG3665	Urea carboxylase-associated protein
C2H91_08410	COG1113	amino acid transport
C2H91_08415	COG3403	YqcI/YcgG family
C2H91_08420	COG1280	lysine exporter protein (LysE YggA)
C2H91_08425	COG1846	Transcriptional regulator
C2H91_08430	COG2814	Major facilitator Superfamily
C2H91_08435	COG1620	l-lactate permease
C2H91_08440	COG0039	L-malate dehydrogenase activity
C2H91_08445	COG0366	Alpha amylase catalytic
C2H91_08455	COG1288	antiporter activity
C2H91_08460	COG1473	amidohydrolase
C2H91_08465	COG2113	Glycine betaine
C2H91_08470	COG4176	ABC-type proline glycine betaine transport system permease component
C2H91_08475	COG4175	Glycine betaine
C2H91_08475	COG0517	IMP dehydrogenase activity
C2H91_08480	COG0640	Transcriptional regulator
C2H91_08485	COG2814	Major facilitator Superfamily
C2H91_08495	COG0477	Major facilitator Superfamily
C2H91_08500	COG3853	Toxic anion resistance protein (TelA)
C2H91_08510	COG0861	Integral membrane protein TerC family
C2H91_08515	COG2310	stress, protein
C2H91_08520	COG2310	stress, protein
C2H91_08525	COG2310	stress, protein
C2H91_08530	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H91_08535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2H91_08540	COG1121	(ABC) transporter
C2H91_08545	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2H91_08550	COG0366	Alpha amylase catalytic
C2H91_08555	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_08560	COG0457	Tetratricopeptide repeat
C2H91_08565	COG1876	peptidase activity
C2H91_08570	COG1595	DNA-templated transcription, initiation
C2H91_08580	COG1595	DNA-templated transcription, initiation
C2H91_08590	COG0667	Aldo Keto reductase
C2H91_08595	COG1668	transmembrane transport
C2H91_08600	COG4555	ABC transporter
C2H91_08605	COG3279	Response regulator of the LytR AlgR family
C2H91_08610	COG3290	protein histidine kinase activity
C2H91_08615	COG3012	SEC-C Motif Domain Protein
C2H91_08615	COG1405	negative regulation of cell septum assembly
C2H91_08620	COG1714	RDD family
C2H91_08625	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C2H91_08630	COG0252	asparaginase activity
C2H91_08635	COG1309	transcriptional regulator
C2H91_08640	COG0477	Major facilitator Superfamily
C2H91_08645	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2H91_08650	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C2H91_08655	COG0805	protein transport
C2H91_08660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2H91_08665	COG3540	Alkaline phosphatase
C2H91_08675	COG2304	oxidoreductase activity
C2H91_08680	COG3773	Cell wall hydrolase
C2H91_08695	COG1131	(ABC) transporter
C2H91_08700	COG2205	protein histidine kinase activity
C2H91_08705	COG0745	RESPONSE REGULATOR receiver
C2H91_08710	COG0697	spore germination
C2H91_08720	COG3173	Aminoglycoside phosphotransferase
C2H91_08725	COG2721	sulfolactate sulfo-lyase activity
C2H91_08730	COG2186	Transcriptional regulator
C2H91_08735	COG4948	Mandelate Racemase Muconate Lactonizing
C2H91_08740	COG2271	Major facilitator Superfamily
C2H91_08745	COG1012	belongs to the aldehyde dehydrogenase family
C2H91_08750	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2H91_08760	COG0784	Response regulator, receiver
C2H91_08765	COG4191	Histidine kinase
C2H91_08770	COG2066	Belongs to the glutaminase family
C2H91_08775	COG1115	amino acid carrier protein
C2H91_08785	COG2040	homocysteine
C2H91_08790	COG0833	amino acid
C2H91_08795	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2H91_08805	COG2188	Transcriptional regulator
C2H91_08810	COG0363	glucosamine-6-phosphate deaminase activity
C2H91_08815	COG2190	(PTS) system
C2H91_08815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H91_08815	COG1263	PTS System
C2H91_08820	COG1301	dicarboxylic acid transport
C2H91_08825	COG1054	Belongs to the UPF0176 family
C2H91_08830	COG2207	Transcriptional regulator
C2H91_08835	COG2312	Erythromycin esterase
C2H91_08845	COG0688	phosphatidylethanolamine metabolic process
C2H91_08850	COG0586	Pfam SNARE associated Golgi protein
C2H91_08855	COG1183	phosphatidylcholine synthase activity
C2H91_08860	COG0596	Alpha beta hydrolase
C2H91_08870	COG3591	Belongs to the peptidase S1B family
C2H91_08875	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C2H91_08880	COG5444	nuclease activity
C2H91_08885	COG1397	ADP-ribosylglycohydrolase
C2H91_08890	COG1917	Cupin 2, conserved barrel domain protein
C2H91_08890	COG2207	Transcriptional regulator
C2H91_08895	COG0697	spore germination
C2H91_08900	COG3409	Peptidoglycan-binding domain 1 protein
C2H91_08910	COG2271	Major facilitator Superfamily
C2H91_08915	COG0456	acetyltransferase
C2H91_08915	COG1846	Transcriptional regulator
C2H91_08930	COG2271	Major facilitator Superfamily
C2H91_08935	COG0584	glycerophosphoryl diester phosphodiesterase
C2H91_08940	COG0531	amino acid
C2H91_08950	COG2124	cytochrome p450
C2H91_08955	COG2602	Beta-lactamase
C2H91_08970	COG1113	amino acid transport
C2H91_08985	COG0515	serine threonine protein kinase
C2H91_08995	COG0642	Histidine kinase
C2H91_09000	COG0745	RESPONSE REGULATOR receiver
C2H91_09005	COG0596	Alpha beta hydrolase
C2H91_09020	COG2814	Major facilitator Superfamily
C2H91_09025	COG0640	Transcriptional regulator
C2H91_09030	COG5609	conserved protein (DUF2294)
C2H91_09040	COG0288	reversible hydration of carbon dioxide
C2H91_09045	COG3002	Belongs to the UPF0753 family
C2H91_09050	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2H91_09060	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2H91_09065	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2H91_09070	COG4856	YbbR-like protein
C2H91_09075	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C2H91_09080	COG5662	AntiSigma factor
C2H91_09085	COG1595	DNA-templated transcription, initiation
C2H91_09115	COG1683	Conserved Protein
C2H91_09120	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H91_09125	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C2H91_09130	COG1737	Transcriptional regulator
C2H91_09135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H91_09135	COG1263	PTS System
C2H91_09140	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2H91_09145	COG1472	Belongs to the glycosyl hydrolase 3 family
C2H91_09150	COG3876	Protein conserved in bacteria
C2H91_09155	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H91_09155	COG2207	Transcriptional regulator
C2H91_09160	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H91_09165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H91_09170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H91_09175	COG2819	hydrolase of the alpha beta superfamily
C2H91_09180	COG0385	Bile acid
C2H91_09185	COG0659	secondary active sulfate transmembrane transporter activity
C2H91_09270	COG0726	polysaccharide deacetylase
C2H91_09275	COG2194	sulfuric ester hydrolase activity
C2H91_09285	COG0489	protein tyrosine kinase activity
C2H91_09290	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H91_09300	COG2226	methyltransferase
C2H91_09305	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C2H91_09310	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2H91_09315	COG0101	tRNA pseudouridine synthase activity
C2H91_09320	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C2H91_09330	COG1122	ATPase activity
C2H91_09335	COG0203	ribosomal protein L17
C2H91_09340	COG0202	RNA polymerase activity
C2H91_09345	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C2H91_09350	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C2H91_09355	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2H91_09365	COG2163	COG2163 Ribosomal protein L14E L6E L27E
C2H91_09370	COG0024	Methionine aminopeptidase
C2H91_09375	COG0563	adenylate kinase activity
C2H91_09380	COG0201	protein transport
C2H91_09385	COG0200	Binds to the 23S rRNA
C2H91_09395	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C2H91_09400	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C2H91_09405	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C2H91_09410	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C2H91_09420	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C2H91_09430	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C2H91_09435	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C2H91_09445	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2H91_09450	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
C2H91_09465	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C2H91_09475	COG0088	Forms part of the polypeptide exit tunnel
C2H91_09480	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C2H91_09490	COG0596	Alpha beta hydrolase
C2H91_09495	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2H91_09500	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2H91_09505	COG0049	tRNA binding
C2H91_09510	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C2H91_09515	COG1358	cellular component organization or biogenesis
C2H91_09520	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C2H91_09525	COG0085	RNA polymerase activity
C2H91_09530	COG2813	Specifically methylates the guanine in position
C2H91_09540	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C2H91_09545	COG0081	regulation of translation
C2H91_09555	COG0250	Participates in transcription elongation, termination and antitermination
C2H91_09560	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2H91_09570	COG1595	DNA-templated transcription, initiation
C2H91_09575	COG3688	RNA-binding protein containing a PIN domain
C2H91_09580	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2H91_09585	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C2H91_09590	COG0215	cysteine-tRNA ligase activity
C2H91_09595	COG1045	serine acetyltransferase
C2H91_09605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2H91_09610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C2H91_09615	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C2H91_09620	COG4956	integral membrane protein (PIN domain superfamily)
C2H91_09625	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C2H91_09630	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2H91_09635	COG0542	response to heat
C2H91_09640	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C2H91_09645	COG3880	PFAM UvrB UvrC protein
C2H91_09650	COG4463	regulation of RNA biosynthetic process
C2H91_09730	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2H91_09735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2H91_09740	COG1396	sequence-specific DNA binding
C2H91_09745	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2H91_09750	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2H91_09755	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2H91_09760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2H91_09765	COG0512	Glutamine amidotransferase of anthranilate synthase
C2H91_09770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2H91_09775	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2H91_09780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2H91_09785	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C2H91_09790	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C2H91_09795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2H91_09800	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C2H91_09805	COG0037	tRNA processing
C2H91_09810	COG0515	serine threonine protein kinase
C2H91_09815	COG2304	oxidoreductase activity
C2H91_09820	COG2208	phosphoserine phosphatase activity
C2H91_09835	COG1098	S1 RNA binding domain
C2H91_09840	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C2H91_09855	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C2H91_09860	COG3956	TIGRFAM MazG family protein
C2H91_09865	COG2244	polysaccharide biosynthetic process
C2H91_09870	COG2002	toxin-antitoxin pair type II binding
C2H91_09875	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2H91_09885	COG0193	aminoacyl-tRNA hydrolase activity
C2H91_09890	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C2H91_09895	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2H91_09900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2H91_09905	COG2088	sporulation resulting in formation of a cellular spore
C2H91_09910	COG0251	oxidation-reduction process
C2H91_09915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2H91_09920	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C2H91_09930	COG4466	Protein conserved in bacteria
C2H91_09940	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2H91_09945	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C2H91_09950	COG3583	domain protein
C2H91_09950	COG3584	3D domain protein
C2H91_09955	COG0084	hydrolase, TatD family'
C2H91_09960	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H91_09960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H91_09965	COG2002	toxin-antitoxin pair type II binding
C2H91_09970	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2H91_09975	COG2827	Endonuclease containing a URI domain
C2H91_09980	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C2H91_09985	COG4467	Involved in initiation control of chromosome replication
C2H91_09990	COG1774	PSP1 C-terminal conserved region
C2H91_09995	COG0470	DNA polymerase III
C2H91_10000	COG1728	Protein conserved in bacteria
C2H91_10005	COG3870	Protein conserved in bacteria
C2H91_10010	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C2H91_10015	COG1982	Orn Lys Arg decarboxylase major
C2H91_10020	COG3853	Toxic anion resistance protein (TelA)
C2H91_10025	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
C2H91_10070	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C2H91_10075	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C2H91_10080	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C2H91_10090	COG0590	tRNA wobble adenosine to inosine editing
C2H91_10095	COG1335	isochorismatase
C2H91_10100	COG3858	chitin binding
C2H91_10100	COG1388	LysM domain
C2H91_10105	COG1428	Deoxynucleoside kinase
C2H91_10110	COG1428	Deoxynucleoside kinase
C2H91_10120	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C2H91_10125	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C2H91_10130	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C2H91_10135	COG1686	Belongs to the peptidase S11 family
C2H91_10140	COG0516	GMP reductase activity
C2H91_10140	COG0517	IMP dehydrogenase activity
C2H91_10175	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2H91_10180	COG0187	DNA topoisomerase II activity
C2H91_10190	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2H91_10195	COG2501	S4 domain
C2H91_10200	COG0592	DNA-directed DNA polymerase activity
C2H91_10205	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C2H91_10215	COG0594	ribonuclease P activity
C2H91_10220	COG0706	membrane insertase activity
C2H91_10225	COG1847	R3H domain protein
C2H91_10230	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C2H91_10235	COG0445	tRNA wobble uridine modification
C2H91_10240	COG0357	Ribosomal RNA small subunit methyltransferase G
C2H91_10245	COG1475	DNA binding
C2H91_10255	COG1192	Involved in chromosome partitioning
C2H91_10260	COG1475	DNA binding
C2H91_10270	COG3949	Membrane
C2H91_10275	COG4481	Protein conserved in bacteria
C2H91_10280	COG0243	molybdopterin cofactor binding
C2H91_10285	COG0012	GTP binding
C2H91_10290	COG0360	Binds together with S18 to 16S ribosomal RNA
C2H91_10295	COG0629	single-stranded DNA binding
C2H91_10300	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2H91_10305	COG0708	Exodeoxyribonuclease III
C2H91_10310	COG1609	Transcriptional regulator
C2H91_10315	COG0346	lactoylglutathione lyase activity
C2H91_10320	COG0110	maltose O-acetyltransferase activity
C2H91_10325	COG2814	Major facilitator Superfamily
C2H91_10325	COG0477	Major facilitator Superfamily
C2H91_10330	COG1266	CAAX protease self-immunity
C2H91_10335	COG1331	Highly conserved protein containing a thioredoxin domain
C2H91_10345	COG0640	Transcriptional regulator
C2H91_10355	COG0798	PFAM Bile acid sodium symporter
C2H91_10360	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2H91_10370	COG2814	Major facilitator Superfamily
C2H91_10375	COG1331	Highly conserved protein containing a thioredoxin domain
C2H91_10380	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2H91_10385	COG2315	Protein conserved in bacteria
C2H91_10390	COG0456	acetyltransferase
C2H91_10395	COG2364	Membrane
C2H91_10400	COG2153	protein acetylation
C2H91_10405	COG1846	Transcriptional regulator
C2H91_10410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H91_10425	COG2153	protein acetylation
C2H91_10430	COG0583	DNA-binding transcription factor activity
C2H91_10435	COG2814	Major facilitator Superfamily
C2H91_10440	COG1357	PFAM Pentapeptide repeats (8 copies)
C2H91_10445	COG4319	ketosteroid isomerase
C2H91_10455	COG4978	Transcriptional regulator
C2H91_10455	COG0789	Transcriptional regulator
C2H91_10460	COG2271	Major facilitator Superfamily
C2H91_10475	COG1227	inorganic diphosphatase activity
C2H91_10480	COG1733	regulation of RNA biosynthetic process
C2H91_10485	COG5577	PFAM Coat F domain
C2H91_10495	COG4241	membrane
C2H91_10500	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
C2H91_10505	COG0359	binds to the 23S rRNA
C2H91_10510	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2H91_10515	COG2807	transmembrane transport
C2H91_10520	COG3093	addiction module antidote protein HigA
C2H91_10535	COG0305	Participates in initiation and elongation during chromosome replication
C2H91_10540	COG0346	lactoylglutathione lyase activity
C2H91_10570	COG0745	RESPONSE REGULATOR receiver
C2H91_10575	COG5002	protein histidine kinase activity
C2H91_10580	COG4863	YycH protein
C2H91_10585	COG4853	Protein conserved in bacteria
C2H91_10590	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C2H91_10595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H91_10610	COG3829	transcription factor binding
C2H91_10615	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2H91_10620	COG0833	amino acid
C2H91_10625	COG0010	Belongs to the arginase family
C2H91_10635	COG0457	Tetratricopeptide repeat
C2H91_10640	COG0456	acetyltransferase
C2H91_10645	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
C2H91_10665	COG1063	alcohol dehydrogenase
C2H91_10680	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C2H91_10700	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
C2H91_10705	COG1131	(ABC) transporter
C2H91_10720	COG2188	Transcriptional regulator
C2H91_10735	COG2723	6-phospho-beta-galactosidase activity
C2H91_10745	COG3634	alkyl hydroperoxide reductase activity
C2H91_10750	COG0450	alkyl hydroperoxide reductase
C2H91_10755	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C2H91_10760	COG2610	gluconate transmembrane transporter activity
C2H91_10765	COG1070	Carbohydrate kinase
C2H91_10770	COG1802	Transcriptional regulator
C2H91_10775	COG1929	Belongs to the glycerate kinase type-1 family
C2H91_10780	COG5039	Polysaccharide pyruvyl transferase
C2H91_10785	COG1346	cytolysis
C2H91_10790	COG1380	Effector of murein hydrolase LrgA
C2H91_10795	COG1846	Transcriptional regulator
C2H91_10805	COG1309	transcriptional regulator
C2H91_10810	COG1917	Cupin 2, conserved barrel domain protein
C2H91_10815	COG2311	Membrane
C2H91_10820	COG1714	RDD family
C2H91_10830	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2H91_10840	COG1012	belongs to the aldehyde dehydrogenase family
C2H91_10845	COG1309	transcriptional regulator
C2H91_10850	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_10860	COG0326	Molecular chaperone. Has ATPase activity
C2H91_10865	COG2814	Major facilitator Superfamily
C2H91_10880	COG0667	Aldo Keto reductase
C2H91_10885	COG1349	DNA-binding transcription factor activity
C2H91_10890	COG1012	belongs to the aldehyde dehydrogenase family
C2H91_10900	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H91_10905	COG3962	Belongs to the TPP enzyme family
C2H91_10910	COG1082	Xylose isomerase domain protein TIM barrel
C2H91_10915	COG2814	Major facilitator Superfamily
C2H91_10920	COG0673	inositol 2-dehydrogenase activity
C2H91_10925	COG1082	Xylose isomerase domain protein TIM barrel
C2H91_10930	COG1082	Xylose isomerase domain protein TIM barrel
C2H91_10935	COG0191	fructose-bisphosphate aldolase activity
C2H91_10940	COG0745	RESPONSE REGULATOR receiver
C2H91_10945	COG2205	protein histidine kinase activity
C2H91_10950	COG1136	(ABC) transporter
C2H91_10955	COG0577	efflux transmembrane transporter activity
C2H91_10960	COG5294	Protein conserved in bacteria
C2H91_10965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H91_10995	COG0561	phosphatase activity
C2H91_11000	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C2H91_11010	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H91_11015	COG0456	acetyltransferase
C2H91_11020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H91_11025	COG0765	amino acid transport
C2H91_11030	COG1126	abc transporter atp-binding protein
C2H91_11035	COG1473	amidohydrolase
C2H91_11040	COG2079	MmgE PrpD family protein
C2H91_11045	COG3192	ethanolamine utilization protein
C2H91_11055	COG2390	Transcriptional regulator
C2H91_11060	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C2H91_11065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2H91_11070	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C2H91_11075	COG0833	amino acid
C2H91_11080	COG0010	Belongs to the arginase family
C2H91_11085	COG1228	amidohydrolase
C2H91_11090	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C2H91_11095	COG2986	histidine ammonia-lyase
C2H91_11110	COG3507	Belongs to the glycosyl hydrolase 43 family
C2H91_11120	COG0494	nUDIX hydrolase
C2H91_11150	COG1263	PTS System
C2H91_11150	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H91_11150	COG2190	(PTS) system
C2H91_11155	COG2723	6-phospho-beta-galactosidase activity
C2H91_11160	COG0589	response to stress
C2H91_11175	COG0697	spore germination
C2H91_11220	COG2755	lipolytic protein G-D-S-L family
C2H91_11220	COG3401	FG-GAP repeat protein
C2H91_11225	COG0513	Belongs to the DEAD box helicase family
C2H91_11230	COG2270	Major facilitator Superfamily
C2H91_11240	COG3711	transcriptional antiterminator
C2H91_11250	COG2851	Citrate transporter
C2H91_11255	COG0753	catalase activity
C2H91_11255	COG0693	protein deglycase activity
C2H91_11270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2H91_11275	COG0500	methyltransferase
C2H91_11280	COG2610	gluconate transmembrane transporter activity
C2H91_11285	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2H91_11290	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2H91_11295	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_11300	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2H91_11305	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2H91_11310	COG4894	glucomannan catabolic process
C2H91_11320	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2H91_11325	COG2197	response regulator
C2H91_11330	COG4585	Histidine kinase
C2H91_11340	COG0583	DNA-binding transcription factor activity
C2H91_11345	COG1881	PFAM PEBP family protein
C2H91_11350	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2H91_11360	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H91_11365	COG1012	belongs to the aldehyde dehydrogenase family
C2H91_11370	COG2508	Transcriptional regulator
C2H91_11375	COG3842	ATPase activity
C2H91_11380	COG0726	polysaccharide deacetylase
C2H91_11390	COG0501	Belongs to the peptidase M48B family
C2H91_11395	COG3493	citrate carrier protein
C2H91_11400	COG1271	oxidase subunit
C2H91_11405	COG1294	oxidase, subunit
C2H91_11410	COG4988	ABC transporter
C2H91_11415	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2H91_11420	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2H91_11425	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2H91_11430	COG1595	DNA-templated transcription, initiation
C2H91_11450	COG1131	(ABC) transporter
C2H91_11455	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2H91_11460	COG2814	Major facilitator Superfamily
C2H91_11465	COG0753	catalase activity
C2H91_11470	COG2094	Belongs to the DNA glycosylase MPG family
C2H91_11480	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H91_11480	COG3711	transcriptional antiterminator
C2H91_11485	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H91_11490	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H91_11495	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2H91_11500	COG1486	melibiose metabolic process
C2H91_11505	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2H91_11510	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
C2H91_11515	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C2H91_11520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H91_11525	COG1696	Membrane protein involved in D-alanine export
C2H91_11530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H91_11545	COG1575	Belongs to the MenA family. Type 1 subfamily
C2H91_11550	COG2357	RelA SpoT domain protein
C2H91_11555	COG2234	aminopeptidase activity
C2H91_11560	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2H91_11565	COG1846	Transcriptional regulator
C2H91_11570	COG5522	Integral membrane protein (intg_mem_TP0381)
C2H91_11575	COG1442	glycosyl transferase family 8
C2H91_11580	COG3711	transcriptional antiterminator
C2H91_11585	COG1263	PTS System
C2H91_11585	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H91_11590	COG1404	Belongs to the peptidase S8 family
C2H91_11595	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H91_11605	COG0346	lactoylglutathione lyase activity
C2H91_11610	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2H91_11615	COG4895	conserved protein (DUF2196)
C2H91_11620	COG2814	Major facilitator Superfamily
C2H91_11625	COG1346	cytolysis
C2H91_11630	COG1380	Effector of murein hydrolase LrgA
C2H91_11635	COG0583	DNA-binding transcription factor activity
C2H91_11640	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C2H91_11645	COG0352	thiamine-phosphate diphosphorylase activity
C2H91_11655	COG0672	)-iron permease
C2H91_11660	COG2822	iron ion transport
C2H91_11665	COG2837	iron assimilation
C2H91_11670	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C2H91_11675	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H91_11680	COG3162	membrane
C2H91_11690	COG1309	transcriptional regulator
C2H91_11695	COG2246	polysaccharide biosynthetic process
C2H91_11700	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C2H91_11705	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C2H91_11710	COG2261	transglycosylase associated protein
C2H91_11715	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2H91_11720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2H91_11725	COG1845	cytochrome c oxidase, subunit III
C2H91_11730	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2H91_11740	COG0772	Belongs to the SEDS family
C2H91_11745	COG0778	Nitroreductase
C2H91_11750	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H91_11755	COG1404	Belongs to the peptidase S8 family
C2H91_11765	COG3711	transcriptional antiterminator
C2H91_11770	COG2116	formate transmembrane transporter activity
C2H91_11775	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H91_11775	COG1263	PTS System
C2H91_11780	COG1621	beta-fructofuranosidase activity
C2H91_11790	COG0351	phosphomethylpyrimidine kinase
C2H91_11795	COG1695	Transcriptional regulator
C2H91_11810	COG1216	Glycosyl transferase, family 2
C2H91_11815	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C2H91_11820	COG1012	belongs to the aldehyde dehydrogenase family
C2H91_11830	COG2233	PERMEase
C2H91_11835	COG2363	Small membrane protein
C2H91_11850	COG0463	Glycosyl transferase, family 2
C2H91_11855	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C2H91_11860	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2H91_11865	COG0456	acetyltransferase
C2H91_11870	COG2089	acid synthase
C2H91_11875	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
C2H91_11880	COG3980	spore coat polysaccharide biosynthesis protein
C2H91_11885	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C2H91_11890	COG1088	dTDP-glucose 4,6-dehydratase activity
C2H91_11895	COG1091	dTDP-4-dehydrorhamnose reductase activity
C2H91_11900	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C2H91_11910	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2H91_11915	COG1012	belongs to the aldehyde dehydrogenase family
C2H91_11920	COG4187	Peptidase family M20/M25/M40
C2H91_11925	COG0833	amino acid
C2H91_11930	COG2814	Major facilitator Superfamily
C2H91_11935	COG0077	Prephenate dehydratase
C2H91_11940	COG1917	Cupin 2, conserved barrel domain protein
C2H91_11945	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_11950	COG0151	Belongs to the GarS family
C2H91_11955	COG2814	Major facilitator Superfamily
C2H91_11960	COG0436	Aminotransferase
C2H91_11965	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_11970	COG3253	May function as heme-dependent peroxidase
C2H91_11975	COG0280	phosphate acetyltransferase
C2H91_11980	COG0583	DNA-binding transcription factor activity
C2H91_11985	COG0095	Lipoate-protein ligase
C2H91_11990	COG0697	spore germination
C2H91_12000	COG4844	belongs to the
C2H91_12005	COG1078	dGTPase activity
C2H91_12010	COG3465	dGTPase activity
C2H91_12015	COG1959	2 iron, 2 sulfur cluster binding
C2H91_12020	COG0477	Major facilitator Superfamily
C2H91_12025	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2H91_12030	COG1846	Transcriptional regulator
C2H91_12035	COG1942	4-Oxalocrotonate Tautomerase
C2H91_12040	COG1994	Peptidase M50
C2H91_12055	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2H91_12060	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C2H91_12065	COG0010	Belongs to the arginase family
C2H91_12080	COG0457	Tetratricopeptide repeat
C2H91_12090	COG3391	amine dehydrogenase activity
C2H91_12095	COG3391	amine dehydrogenase activity
C2H91_12105	COG0612	Peptidase, M16
C2H91_12110	COG0612	Peptidase, M16
C2H91_12115	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C2H91_12120	COG1131	(ABC) transporter
C2H91_12130	COG0535	radical SAM domain protein
C2H91_12145	COG4506	Protein conserved in bacteria
C2H91_12150	COG0018	arginyl-trna synthetase
C2H91_12155	COG2223	nitrite transmembrane transporter activity
C2H91_12160	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2H91_12170	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2H91_12175	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2H91_12180	COG1140	nitrate reductase beta subunit
C2H91_12185	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2H91_12190	COG2181	nitrate reductase activity
C2H91_12200	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2H91_12205	COG1132	(ABC) transporter
C2H91_12210	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2H91_12220	COG4294	response to UV
C2H91_12225	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2H91_12230	COG2181	nitrate reductase activity
C2H91_12230	COG0247	lactate metabolic process
C2H91_12235	COG1960	acyl-CoA dehydrogenase activity
C2H91_12240	COG3343	RNA polymerase activity
C2H91_12245	COG0504	CTP synthase activity
C2H91_12250	COG4821	SIS domain
C2H91_12255	COG2204	response regulator
C2H91_12260	COG0191	fructose-bisphosphate aldolase activity
C2H91_12265	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2H91_12270	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2H91_12275	COG1494	fructose-1,6-bisphosphatase
C2H91_12280	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2H91_12290	COG1435	thymidine kinase activity
C2H91_12295	COG0281	malic enzyme
C2H91_12300	COG0679	Auxin Efflux Carrier
C2H91_12305	COG0789	Transcriptional regulator
C2H91_12310	COG0346	lactoylglutathione lyase activity
C2H91_12315	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C2H91_12320	COG2890	protein-(glutamine-N5) methyltransferase activity
C2H91_12340	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2H91_12345	COG0009	L-threonylcarbamoyladenylate synthase
C2H91_12350	COG1971	Probably functions as a manganese efflux pump
C2H91_12355	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2H91_12360	COG0698	ribose 5-phosphate isomerase
C2H91_12365	COG4475	Protein of unknown function (DUF436)
C2H91_12370	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2H91_12375	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C2H91_12385	COG0356	it plays a direct role in the translocation of protons across the membrane
C2H91_12395	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C2H91_12400	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2H91_12405	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C2H91_12410	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C2H91_12415	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C2H91_12420	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C2H91_12430	COG4836	Membrane
C2H91_12440	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2H91_12445	COG2385	sporulation resulting in formation of a cellular spore
C2H91_12450	COG2304	oxidoreductase activity
C2H91_12460	COG2304	oxidoreductase activity
C2H91_12470	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2H91_12475	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2H91_12480	COG0457	Tetratricopeptide repeat
C2H91_12485	COG1994	Peptidase M50
C2H91_12490	COG3237	CsbD-like
C2H91_12505	COG0831	urea catabolic process
C2H91_12510	COG0832	Belongs to the urease beta subunit family
C2H91_12515	COG0804	urea catabolic process
C2H91_12520	COG1959	2 iron, 2 sulfur cluster binding
C2H91_12525	COG2910	NAD(P)H-binding
C2H91_12535	COG0789	Transcriptional regulator
C2H91_12545	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2H91_12560	COG1247	-acetyltransferase
C2H91_12565	COG0739	heme binding
C2H91_12575	COG0671	phosphoesterase, PA-phosphatase related
C2H91_12580	COG0347	Belongs to the P(II) protein family
C2H91_12585	COG0004	ammonium transporteR
C2H91_12595	COG1335	isochorismatase
C2H91_12600	COG0477	Major facilitator Superfamily
C2H91_12605	COG1953	Uracil, thiamine, allantoin
C2H91_12610	COG3420	alginic acid biosynthetic process
C2H91_12615	COG2814	Major facilitator Superfamily
C2H91_12620	COG1846	Transcriptional regulator
C2H91_12630	COG1609	Transcriptional regulator
C2H91_12635	COG1077	Cell shape determining protein MreB Mrl
C2H91_12640	COG4786	Flagellar basal body rod
C2H91_12645	COG4786	Flagellar basal body rod
C2H91_12650	COG0457	Tetratricopeptide repeat
C2H91_12655	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2H91_12660	COG1970	mechanosensitive ion channel activity
C2H91_12665	COG2972	Histidine kinase
C2H91_12665	COG0745	RESPONSE REGULATOR receiver
C2H91_12670	COG3279	Response regulator of the LytR AlgR family
C2H91_12680	COG3764	Sortase (surface protein transpeptidase)
C2H91_12695	COG0629	single-stranded DNA binding
C2H91_12700	COG1349	DNA-binding transcription factor activity
C2H91_12705	COG0561	phosphatase activity
C2H91_12715	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2H91_12720	COG4715	Zinc finger, swim domain protein
C2H91_12730	COG3944	biosynthesis protein
C2H91_12735	COG0489	protein tyrosine kinase activity
C2H91_12740	COG4464	protein tyrosine phosphatase activity
C2H91_12745	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C2H91_12750	COG3878	Protein conserved in bacteria
C2H91_12770	COG5444	nuclease activity
C2H91_12780	COG1515	deoxyribonuclease V activity
C2H91_12785	COG2059	Chromate
C2H91_12790	COG2059	Chromate
C2H91_12795	COG1522	sequence-specific DNA binding
C2H91_12800	COG0405	Gamma-glutamyltransferase
C2H91_12810	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2H91_12820	COG5337	Spore coat protein CotH
C2H91_12835	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2H91_12840	COG0583	DNA-binding transcription factor activity
C2H91_12845	COG0028	Belongs to the TPP enzyme family
C2H91_12850	COG3527	Alpha-acetolactate decarboxylase
C2H91_12855	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2H91_12865	COG3103	Sh3 type 3 domain protein
C2H91_12870	COG1879	ABC-type sugar transport system periplasmic component
C2H91_12875	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2H91_12880	COG1129	ABC transporter
C2H91_12885	COG1869	D-ribose catabolic process
C2H91_12890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H91_12895	COG1609	Transcriptional regulator
C2H91_12900	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2H91_12910	COG2843	Capsule synthesis protein
C2H91_12920	COG0791	NLP P60 protein
C2H91_12925	COG0561	phosphatase activity
C2H91_12930	COG1316	TRANSCRIPTIONal
C2H91_12935	COG2814	Major facilitator Superfamily
C2H91_12945	COG0814	amino acid
C2H91_12950	COG0697	spore germination
C2H91_12955	COG1482	cell wall glycoprotein biosynthetic process
C2H91_12960	COG4193	domain, Protein
C2H91_13005	COG0463	Glycosyl transferase, family 2
C2H91_13025	COG1682	transport, permease protein
C2H91_13030	COG1134	teichoic acid transport
C2H91_13035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2H91_13055	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2H91_13060	COG1316	TRANSCRIPTIONal
C2H91_13070	COG2247	cell wall binding repeat
C2H91_13070	COG2385	sporulation resulting in formation of a cellular spore
C2H91_13075	COG2247	cell wall binding repeat
C2H91_13075	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H91_13090	COG2244	polysaccharide biosynthetic process
C2H91_13095	COG0297	glycogen (starch) synthase activity
C2H91_13095	COG0438	transferase activity, transferring glycosyl groups
C2H91_13100	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C2H91_13105	COG3307	-O-antigen
C2H91_13110	COG3206	protein involved in exopolysaccharide biosynthesis
C2H91_13115	COG1215	transferase activity, transferring glycosyl groups
C2H91_13120	COG0438	transferase activity, transferring glycosyl groups
C2H91_13125	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2H91_13130	COG1316	TRANSCRIPTIONal
C2H91_13135	COG1739	Uncharacterized protein family UPF0029
C2H91_13140	COG4585	Histidine kinase
C2H91_13145	COG2197	response regulator
C2H91_13150	COG1307	EDD domain protein, DegV family
C2H91_13155	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C2H91_13165	COG1040	competence protein
C2H91_13175	COG2747	anti-sigma28 factor FlgM
C2H91_13180	COG3418	PFAM FlgN family protein
C2H91_13185	COG4786	Flagellar basal body rod
C2H91_13185	COG1256	bacterial-type flagellum assembly
C2H91_13190	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2H91_13200	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
C2H91_13205	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C2H91_13210	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2H91_13215	COG1334	flagellar protein FlaG
C2H91_13220	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C2H91_13225	COG1516	flagellar protein fliS
C2H91_13240	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2H91_13245	COG0653	protein targeting
C2H91_13255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H91_13260	COG2010	Cytochrome c
C2H91_13265	COG2884	Cell division ATP-binding protein ftsE
C2H91_13270	COG2177	Part of the ABC transporter FtsEX involved in
C2H91_13275	COG0793	Belongs to the peptidase S41A family
C2H91_13275	COG3409	Peptidoglycan-binding domain 1 protein
C2H91_13285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H91_13290	COG2814	Major facilitator Superfamily
C2H91_13295	COG1309	transcriptional regulator
C2H91_13300	COG3848	Pyruvate phosphate dikinase
C2H91_13300	COG0574	Belongs to the PEP-utilizing enzyme family
C2H91_13305	COG4897	Protein conserved in bacteria
C2H91_13310	COG0556	nucleotide-excision repair
C2H91_13315	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2H91_13320	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2H91_13335	COG3595	metallopeptidase activity
C2H91_13340	COG1983	PspC domain protein
C2H91_13345	COG1950	PFAM Membrane protein of
C2H91_13350	COG2814	Major facilitator Superfamily
C2H91_13355	COG1846	Transcriptional regulator
C2H91_13365	COG2124	cytochrome p450
C2H91_13370	COG1846	Transcriptional regulator
C2H91_13375	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2H91_13380	COG2188	Transcriptional regulator
C2H91_13385	COG0363	glucosamine-6-phosphate deaminase activity
C2H91_13390	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2H91_13395	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C2H91_13400	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C2H91_13405	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C2H91_13410	COG0546	phosphoglycolate phosphatase activity
C2H91_13415	COG0110	maltose O-acetyltransferase activity
C2H91_13420	COG5297	Belongs to the glycosyl hydrolase family 6
C2H91_13425	COG4990	cell redox homeostasis
C2H91_13430	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C2H91_13435	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C2H91_13440	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C2H91_13445	COG0131	Imidazoleglycerol-phosphate dehydratase
C2H91_13450	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2H91_13455	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C2H91_13460	COG0107	imidazoleglycerol-phosphate synthase activity
C2H91_13465	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2H91_13465	COG0140	phosphoribosyl-ATP diphosphatase activity
C2H91_13485	COG1132	(ABC) transporter
C2H91_13490	COG0457	Tetratricopeptide repeat
C2H91_13495	COG3883	PFAM NLP P60 protein
C2H91_13495	COG0791	NLP P60 protein
C2H91_13500	COG0492	ferredoxin-NADP+ reductase activity
C2H91_13505	COG1051	belongs to the nudix hydrolase family
C2H91_13510	COG1660	Displays ATPase and GTPase activities
C2H91_13515	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C2H91_13520	COG1481	regulation of sporulation
C2H91_13525	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H91_13530	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C2H91_13540	COG0745	RESPONSE REGULATOR receiver
C2H91_13545	COG5002	protein histidine kinase activity
C2H91_13550	COG1136	(ABC) transporter
C2H91_13555	COG0577	efflux transmembrane transporter activity
C2H91_13560	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2H91_13565	COG0288	reversible hydration of carbon dioxide
C2H91_13570	COG0659	secondary active sulfate transmembrane transporter activity
C2H91_13575	COG1694	Mazg nucleotide pyrophosphohydrolase
C2H91_13580	COG1611	Belongs to the LOG family
C2H91_13585	COG1609	Transcriptional regulator
C2H91_13590	COG0366	Alpha amylase catalytic
C2H91_13595	COG2182	Extracellular solute-binding protein
C2H91_13600	COG1175	transmembrane transport
C2H91_13605	COG3833	ABC-type maltose transport systems, permease component
C2H91_13610	COG5521	maltodextrose utilization protein MalA
C2H91_13615	COG1554	hydrolase, family 65, central catalytic
C2H91_13620	COG0366	Alpha amylase catalytic
C2H91_13625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2H91_13630	COG0740	serine-type endopeptidase activity
C2H91_13645	COG2076	Multidrug Resistance protein
C2H91_13650	COG2076	Multidrug Resistance protein
C2H91_13655	COG1309	transcriptional regulator
C2H91_13660	COG0531	amino acid
C2H91_13665	COG1621	beta-fructofuranosidase activity
C2H91_13670	COG1621	beta-fructofuranosidase activity
C2H91_13680	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2H91_13685	COG1794	racemase activity, acting on amino acids and derivatives
C2H91_13695	COG3479	Phenolic acid decarboxylase
C2H91_13705	COG2272	Belongs to the type-B carboxylesterase lipase family
C2H91_13710	COG1396	sequence-specific DNA binding
C2H91_13715	COG3944	biosynthesis protein
C2H91_13720	COG0489	protein tyrosine kinase activity
C2H91_13725	COG1086	Polysaccharide biosynthesis protein
C2H91_13730	COG0438	transferase activity, transferring glycosyl groups
C2H91_13735	COG1215	transferase activity, transferring glycosyl groups
C2H91_13740	COG0438	transferase activity, transferring glycosyl groups
C2H91_13750	COG1216	Glycosyl transferase, family 2
C2H91_13755	COG5039	Polysaccharide pyruvyl transferase
C2H91_13760	COG1216	Glycosyl transferase, family 2
C2H91_13765	COG2244	polysaccharide biosynthetic process
C2H91_13770	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2H91_13775	COG0110	maltose O-acetyltransferase activity
C2H91_13780	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2H91_13785	COG5039	Polysaccharide pyruvyl transferase
C2H91_13795	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2H91_13800	COG1620	l-lactate permease
C2H91_13805	COG2186	Transcriptional regulator
C2H91_13810	COG1609	Transcriptional regulator
C2H91_13815	COG2182	Extracellular solute-binding protein
C2H91_13820	COG1175	transmembrane transport
C2H91_13825	COG3833	ABC-type maltose transport systems, permease component
C2H91_13830	COG1874	Beta-galactosidase
C2H91_13835	COG3867	Arabinogalactan endo-beta-1,4-galactanase
C2H91_13840	COG2208	phosphoserine phosphatase activity
C2H91_13845	COG0596	Alpha beta hydrolase
C2H91_13850	COG1131	(ABC) transporter
C2H91_13855	COG0842	Transport permease protein
C2H91_13860	COG4585	Histidine kinase
C2H91_13865	COG2197	response regulator
C2H91_13870	COG0247	lactate metabolic process
C2H91_13875	COG1139	Iron-sulfur cluster binding protein
C2H91_13880	COG1556	Lactate utilization protein
C2H91_13885	COG3858	chitin binding
C2H91_13890	COG1113	amino acid transport
C2H91_13895	COG0697	spore germination
C2H91_13900	COG0583	DNA-binding transcription factor activity
C2H91_13910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H91_13915	COG1609	Transcriptional regulator
C2H91_13920	COG2814	Major facilitator Superfamily
C2H91_13925	COG2390	Transcriptional regulator
C2H91_13930	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2H91_13935	COG0126	phosphoglycerate kinase activity
C2H91_13940	COG0149	triose-phosphate isomerase activity
C2H91_13945	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C2H91_13950	COG0148	phosphopyruvate hydratase activity
C2H91_13955	COG2234	aminopeptidase activity
C2H91_13965	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2H91_13970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H91_13990	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2H91_14005	COG0456	acetyltransferase
C2H91_14010	COG4640	response to antibiotic
C2H91_14015	COG3064	Membrane
C2H91_14025	COG2095	MarC family integral membrane protein
C2H91_14030	COG1510	regulation of RNA biosynthetic process
C2H91_14035	COG1125	glycine betaine transport
C2H91_14035	COG0517	IMP dehydrogenase activity
C2H91_14040	COG1174	glycine betaine transport
C2H91_14045	COG1732	Glycine betaine
C2H91_14050	COG1174	glycine betaine transport
C2H91_14055	COG1510	regulation of RNA biosynthetic process
C2H91_14060	COG1125	glycine betaine transport
C2H91_14060	COG0517	IMP dehydrogenase activity
C2H91_14065	COG1174	glycine betaine transport
C2H91_14070	COG1732	Glycine betaine
C2H91_14075	COG1174	glycine betaine transport
C2H91_14080	COG0840	transmembrane signaling receptor activity
C2H91_14085	COG1733	regulation of RNA biosynthetic process
C2H91_14090	COG1396	sequence-specific DNA binding
C2H91_14095	COG1396	sequence-specific DNA binding
C2H91_14100	COG1476	TRANSCRIPTIONal
C2H91_14105	COG0596	Alpha beta hydrolase
C2H91_14110	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2H91_14115	COG1647	Serine aminopeptidase, S33
C2H91_14120	COG0557	exoribonuclease II activity
C2H91_14125	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C2H91_14135	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_14140	COG1309	transcriptional regulator
C2H91_14145	COG2076	Multidrug Resistance protein
C2H91_14155	COG1289	transmembrane transporter activity
C2H91_14160	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2H91_14165	COG0673	inositol 2-dehydrogenase activity
C2H91_14170	COG1937	Protein conserved in bacteria
C2H91_14175	COG2608	mercury ion transmembrane transporter activity
C2H91_14180	COG2217	Heavy metal translocating P-type atpase
C2H91_14185	COG2217	Heavy metal translocating P-type atpase
C2H91_14190	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2H91_14195	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C2H91_14200	COG2860	membrane
C2H91_14210	COG3973	AAA domain
C2H91_14215	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2H91_14220	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2H91_14225	COG0025	NhaP-type Na H and K H
C2H91_14235	COG0656	L-ascorbic acid biosynthetic process
C2H91_14240	COG4149	molybdate abc transporter
C2H91_14245	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2H91_14250	COG1910	domain protein
C2H91_14255	COG1368	sulfuric ester hydrolase activity
C2H91_14260	COG1988	membrane-bound metal-dependent
C2H91_14275	COG0531	amino acid
C2H91_14280	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H91_14285	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H91_14290	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H91_14295	COG1120	ATPase activity
C2H91_14300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2H91_14305	COG1136	(ABC) transporter
C2H91_14310	COG0577	efflux transmembrane transporter activity
C2H91_14320	COG2140	Oxalate decarboxylase
C2H91_14330	COG1191	sigma factor activity
C2H91_14340	COG0745	RESPONSE REGULATOR receiver
C2H91_14345	COG2205	protein histidine kinase activity
C2H91_14350	COG3386	PFAM SMP-30 Gluconolaconase
C2H91_14355	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_14360	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H91_14365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H91_14370	COG1120	ATPase activity
C2H91_14375	COG2096	Adenosyltransferase
C2H91_14380	COG2814	Major facilitator Superfamily
C2H91_14385	COG4758	membrane
C2H91_14390	COG1842	Phage shock protein A
C2H91_14395	COG3595	metallopeptidase activity
C2H91_14400	COG4758	membrane
C2H91_14405	COG4585	Histidine kinase
C2H91_14410	COG2197	response regulator
C2H91_14420	COG0814	amino acid
C2H91_14425	COG0697	spore germination
C2H91_14435	COG0114	fumarate hydratase activity
C2H91_14440	COG1309	transcriptional regulator
C2H91_14450	COG2770	Histidine kinase
C2H91_14450	COG2205	protein histidine kinase activity
C2H91_14455	COG0745	RESPONSE REGULATOR receiver
C2H91_14460	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H91_14465	COG0783	Belongs to the Dps family
C2H91_14470	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_14485	COG1120	ATPase activity
C2H91_14495	COG0583	DNA-binding transcription factor activity
C2H91_14500	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_14505	COG1942	4-Oxalocrotonate Tautomerase
C2H91_14510	COG0477	Major facilitator Superfamily
C2H91_14515	COG1846	Transcriptional regulator
C2H91_14520	COG5577	PFAM Coat F domain
C2H91_14530	COG0506	proline dehydrogenase activity
C2H91_14540	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2H91_14540	COG1024	Enoyl-CoA hydratase
C2H91_14545	COG0183	Belongs to the thiolase family
C2H91_14550	COG1960	acyl-CoA dehydrogenase activity
C2H91_14555	COG1393	Belongs to the ArsC family
C2H91_14560	COG0509	glycine decarboxylation via glycine cleavage system
C2H91_14570	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C2H91_14575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H91_14585	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2H91_14590	COG2011	ABC-type metal ion transport system permease component
C2H91_14595	COG1464	Belongs to the NlpA lipoprotein family
C2H91_14600	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2H91_14615	COG0396	ATPase activity
C2H91_14620	COG0719	Fe-S assembly protein
C2H91_14625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2H91_14630	COG0822	iron-sulfur transferase activity
C2H91_14635	COG0719	Fe-S assembly protein
C2H91_14640	COG0640	Transcriptional regulator
C2H91_14645	COG0346	lactoylglutathione lyase activity
C2H91_14660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2H91_14665	COG0322	excinuclease ABC activity
C2H91_14670	COG2222	sugar isomerase
C2H91_14675	COG1653	transport
C2H91_14680	COG1175	transmembrane transport
C2H91_14685	COG0395	ABC-type sugar transport system, permease component
C2H91_14690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H91_14695	COG2188	Transcriptional regulator
C2H91_14700	COG3842	ATPase activity
C2H91_14705	COG2356	endonuclease I
C2H91_14710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2H91_14715	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2H91_14720	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C2H91_14725	COG2068	MobA-Related Protein
C2H91_14730	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C2H91_14735	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2H91_14740	COG2080	2 iron, 2 sulfur cluster binding
C2H91_14750	COG2351	hydroxyisourate hydrolase activity
C2H91_14755	COG3648	Uricase
C2H91_14755	COG3195	allantoin biosynthetic process
C2H91_14760	COG2233	PERMEase
C2H91_14765	COG2233	PERMEase
C2H91_14770	COG2508	Transcriptional regulator
C2H91_14775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2H91_14785	COG1801	Protein of unknown function DUF72
C2H91_14790	COG0730	response to heat
C2H91_14795	COG0737	Belongs to the 5'-nucleotidase family
C2H91_14800	COG3377	Domain of unknown function (DUF1805)
C2H91_14810	COG0739	heme binding
C2H91_14815	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2H91_14825	COG4470	Protein conserved in bacteria
C2H91_14830	COG2445	Protein of unknown function DUF86
C2H91_14835	COG0647	UMP catabolic process
C2H91_14840	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2H91_14845	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H91_14850	COG0460	homoserine dehydrogenase
C2H91_14855	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2H91_14860	COG0083	homoserine kinase activity
C2H91_14865	COG0823	Involved in the tonB-independent uptake of proteins
C2H91_14865	COG1506	peptidase
C2H91_14865	COG4946	Tricorn protease homolog
C2H91_14870	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C2H91_14875	COG4837	Protein of unknown function (DUF1462)
C2H91_14880	COG1252	NADH dehydrogenase
C2H91_14885	COG4844	belongs to the
C2H91_14890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2H91_14895	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C2H91_14900	COG0316	Belongs to the HesB IscA family
C2H91_14905	COG0456	acetyltransferase
C2H91_14910	COG2808	Putative FMN-binding domain
C2H91_14915	COG0516	GMP reductase activity
C2H91_14925	COG0492	ferredoxin-NADP+ reductase activity
C2H91_14930	COG1252	NADH dehydrogenase
C2H91_14945	COG3584	3D domain protein
C2H91_14950	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
C2H91_14955	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2H91_14960	COG2056	Na+-H+ antiporter family
C2H91_14965	COG1268	BioY protein
C2H91_14970	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2H91_14975	COG2819	hydrolase of the alpha beta superfamily
C2H91_14980	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_14985	COG1169	isochorismate synthase
C2H91_14990	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2H91_14995	COG3433	isochorismatase activity
C2H91_14995	COG1535	isochorismatase
C2H91_15000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H91_15005	COG3251	PFAM MbtH domain protein
C2H91_15010	COG5634	Uncharacterized conserved protein (DUF2278)
C2H91_15015	COG0686	Belongs to the AlaDH PNT family
C2H91_15020	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C2H91_15020	COG2508	Transcriptional regulator
C2H91_15030	COG4842	Belongs to the WXG100 family
C2H91_15035	COG5417	Belongs to the EsaB family
C2H91_15040	COG4499	WXG100 protein secretion system (Wss), protein YukC
C2H91_15045	COG1674	ftsk spoiiie
C2H91_15045	COG0433	COG0433 Predicted ATPase
C2H91_15050	COG1511	domain protein
C2H91_15060	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_15065	COG1418	mRNA catabolic process
C2H91_15080	COG0628	permease
C2H91_15095	COG5506	Protein of unknown function (DUF1694)
C2H91_15100	COG1335	isochorismatase
C2H91_15105	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C2H91_15110	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C2H91_15125	COG0142	geranyltranstransferase activity
C2H91_15135	COG4585	Histidine kinase
C2H91_15140	COG2197	response regulator
C2H91_15145	COG2050	protein possibly involved in aromatic compounds catabolism
C2H91_15150	COG1320	monovalent cation:proton antiporter activity
C2H91_15155	COG2212	antiporter activity
C2H91_15160	COG1863	multisubunit Na H antiporter MnhE subunit
C2H91_15165	COG0651	ATP synthesis coupled electron transport
C2H91_15170	COG1006	Multisubunit Na H antiporter MnhC subunit
C2H91_15175	COG2111	Na H antiporter
C2H91_15180	COG2111	Na H antiporter
C2H91_15180	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2H91_15190	COG3493	citrate carrier protein
C2H91_15195	COG1079	Belongs to the binding-protein-dependent transport system permease family
C2H91_15200	COG4603	Belongs to the binding-protein-dependent transport system permease family
C2H91_15205	COG3845	ABC transporter
C2H91_15210	COG1744	ABC transporter substrate-binding protein PnrA-like
C2H91_15215	COG4565	transcriptional regulatory protein
C2H91_15220	COG3290	protein histidine kinase activity
C2H91_15230	COG3011	Protein conserved in bacteria
C2H91_15235	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2H91_15240	COG2814	Major facilitator Superfamily
C2H91_15250	COG5018	Exonuclease
C2H91_15260	COG2205	protein histidine kinase activity
C2H91_15265	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2H91_15275	COG2267	carboxylic ester hydrolase activity
C2H91_15280	COG1522	sequence-specific DNA binding
C2H91_15285	COG0436	Aminotransferase
C2H91_15290	COG1098	S1 RNA binding domain
C2H91_15295	COG2155	Conserved Protein
C2H91_15300	COG1979	alcohol dehydrogenase
C2H91_15305	COG1979	alcohol dehydrogenase
C2H91_15310	COG0166	Belongs to the GPI family
C2H91_15325	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2H91_15340	COG2738	Putative neutral zinc metallopeptidase
C2H91_15345	COG1253	flavin adenine dinucleotide binding
C2H91_15350	COG0366	Alpha amylase catalytic
C2H91_15355	COG0432	Pfam Uncharacterised protein family UPF0047
C2H91_15370	COG0840	transmembrane signaling receptor activity
C2H91_15375	COG0840	transmembrane signaling receptor activity
C2H91_15380	COG0840	transmembrane signaling receptor activity
C2H91_15385	COG0840	transmembrane signaling receptor activity
C2H91_15400	COG1349	DNA-binding transcription factor activity
C2H91_15405	COG1070	Carbohydrate kinase
C2H91_15410	COG3254	rhamnose metabolic process
C2H91_15415	COG4806	L-rhamnose isomerase
C2H91_15420	COG0673	inositol 2-dehydrogenase activity
C2H91_15425	COG0628	permease
C2H91_15430	COG1968	undecaprenyl-diphosphatase activity
C2H91_15440	COG5553	Cysteine dioxygenase type I
C2H91_15445	COG0477	Major facilitator Superfamily
C2H91_15450	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2H91_15455	COG4682	membrane
C2H91_15460	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2H91_15465	COG0569	domain protein
C2H91_15475	COG1510	regulation of RNA biosynthetic process
C2H91_15480	COG1012	belongs to the aldehyde dehydrogenase family
C2H91_15485	COG1454	alcohol dehydrogenase
C2H91_15495	COG2318	DinB family
C2H91_15500	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2H91_15505	COG2268	Band 7 protein
C2H91_15510	COG1247	-acetyltransferase
C2H91_15515	COG3859	Proton-coupled thiamine transporter YuaJ
C2H91_15640	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C2H91_15645	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2H91_15650	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2H91_15655	COG0297	glycogen (starch) synthase activity
C2H91_15660	COG0058	SHG alpha-glucan phosphorylase activity
C2H91_15665	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C2H91_15670	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H91_15675	COG0438	transferase activity, transferring glycosyl groups
C2H91_15680	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H91_15690	COG0438	transferase activity, transferring glycosyl groups
C2H91_15695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H91_15700	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C2H91_15705	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2H91_15710	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2H91_15715	COG1169	isochorismate synthase
C2H91_15720	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C2H91_15725	COG0596	Alpha beta hydrolase
C2H91_15730	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C2H91_15735	COG0318	PFAM AMP-dependent synthetase and ligase
C2H91_15740	COG4948	Mandelate Racemase Muconate Lactonizing
C2H91_15745	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2H91_15750	COG1121	(ABC) transporter
C2H91_15755	COG1321	iron dependent repressor
C2H91_15755	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2H91_15760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2H91_15770	COG1294	oxidase, subunit
C2H91_15775	COG1271	oxidase subunit
C2H91_15780	COG0254	rRNA binding
C2H91_15785	COG0288	reversible hydration of carbon dioxide
C2H91_15790	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2H91_15795	COG1854	S-ribosylhomocysteine lyase activity
C2H91_15810	COG0783	Belongs to the Dps family
C2H91_15815	COG4824	toxin secretion phage lysis holin
C2H91_15820	COG0494	nUDIX hydrolase
C2H91_15825	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2H91_15830	COG1116	anion transmembrane transporter activity
C2H91_15835	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2H91_15840	COG1506	peptidase
C2H91_15850	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C2H91_15855	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C2H91_15860	COG0367	asparagine synthase
C2H91_15865	COG1113	amino acid transport
C2H91_15870	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2H91_15875	COG2267	carboxylic ester hydrolase activity
C2H91_15885	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C2H91_15890	COG1242	4 iron, 4 sulfur cluster binding
C2H91_15900	COG1725	Transcriptional regulator
C2H91_15905	COG1131	(ABC) transporter
C2H91_15920	COG1136	(ABC) transporter
C2H91_15925	COG0577	efflux transmembrane transporter activity
C2H91_15930	COG0745	RESPONSE REGULATOR receiver
C2H91_15935	COG2205	protein histidine kinase activity
C2H91_15940	COG1136	(ABC) transporter
C2H91_15945	COG0577	efflux transmembrane transporter activity
C2H91_15955	COG2814	Major facilitator Superfamily
C2H91_15960	COG2202	Pas domain
C2H91_15960	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H91_15970	COG0495	leucyl-tRNA aminoacylation
C2H91_15975	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2H91_15980	COG1486	melibiose metabolic process
C2H91_15985	COG0395	ABC-type sugar transport system, permease component
C2H91_15990	COG1175	transmembrane transport
C2H91_15995	COG1653	transport
C2H91_16000	COG1609	Transcriptional regulator
C2H91_16005	COG1073	alpha beta
C2H91_16015	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2H91_16020	COG0156	8-amino-7-oxononanoate synthase activity
C2H91_16030	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2H91_16035	COG2124	cytochrome p450
C2H91_16040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H91_16045	COG0395	ABC-type sugar transport system, permease component
C2H91_16050	COG1653	transport
C2H91_16055	COG2207	Transcriptional regulator
C2H91_16060	COG4209	transmembrane transport
C2H91_16065	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2H91_16070	COG1653	transport
C2H91_16075	COG0673	inositol 2-dehydrogenase activity
C2H91_16080	COG5578	integral membrane protein
C2H91_16090	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2H91_16095	COG2081	HI0933 family
C2H91_16100	COG2244	polysaccharide biosynthetic process
C2H91_16105	COG1187	pseudouridine synthase activity
C2H91_16110	COG1349	DNA-binding transcription factor activity
C2H91_16115	COG1131	(ABC) transporter
C2H91_16120	COG4473	ABC transporter
C2H91_16125	COG2252	PERMEase
C2H91_16130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2H91_16135	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2H91_16140	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2H91_16150	COG1597	lipid kinase activity
C2H91_16155	COG1523	belongs to the glycosyl hydrolase 13 family
C2H91_16160	COG0510	thiamine kinase activity
C2H91_16170	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2H91_16175	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H91_16180	COG0281	malic enzyme
C2H91_16185	COG5584	Small secreted protein
C2H91_16190	COG1363	Peptidase, m42
C2H91_16200	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H91_16205	COG4848	Belongs to the UPF0354 family
C2H91_16210	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H91_16215	COG1674	ftsk spoiiie
C2H91_16220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2H91_16225	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
C2H91_16230	COG4980	gas vesicle protein
C2H91_16235	COG3118	belongs to the thioredoxin family
C2H91_16240	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C2H91_16240	COG1605	Chorismate mutase
C2H91_16245	COG1609	Transcriptional regulator
C2H91_16250	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2H91_16255	COG1360	Flagellar Motor Protein
C2H91_16260	COG0123	including yeast histone deacetylase and acetoin utilization protein
C2H91_16265	COG0517	IMP dehydrogenase activity
C2H91_16270	COG0454	-acetyltransferase
C2H91_16275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2H91_16285	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2H91_16290	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C2H91_16300	COG2199	diguanylate cyclase activity
C2H91_16300	COG2203	Gaf domain
C2H91_16305	COG1956	GAF domain-containing protein
C2H91_16310	COG1309	transcriptional regulator
C2H91_16315	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2H91_16320	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C2H91_16325	COG1114	Component of the transport system for branched-chain amino acids
C2H91_16330	COG1104	cysteine desulfurase activity
C2H91_16335	COG0301	tRNA thio-modification
C2H91_16345	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2H91_16350	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C2H91_16355	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2H91_16360	COG0616	signal peptide processing
C2H91_16365	COG1714	RDD family
C2H91_16375	COG3874	Sporulation protein YtfJ
C2H91_16380	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C2H91_16385	COG0827	DNA restriction-modification system
C2H91_16395	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2H91_16400	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2H91_16405	COG0137	argininosuccinate synthase activity
C2H91_16410	COG0165	Argininosuccinate lyase
C2H91_16420	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_16425	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2H91_16430	COG4109	DRTGG domain
C2H91_16440	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C2H91_16460	COG0587	DNA-directed DNA polymerase activity
C2H91_16465	COG0281	malic enzyme
C2H91_16470	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C2H91_16475	COG0825	malonyl-CoA metabolic process
C2H91_16480	COG0205	6-phosphofructokinase activity
C2H91_16485	COG0469	pyruvate kinase activity
C2H91_16490	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2H91_16495	COG0628	permease
C2H91_16500	COG2707	UPF0756 membrane protein
C2H91_16505	COG0372	Belongs to the citrate synthase family
C2H91_16510	COG0538	isocitrate dehydrogenase activity
C2H91_16515	COG0039	L-malate dehydrogenase activity
C2H91_16520	COG0745	RESPONSE REGULATOR receiver
C2H91_16525	COG5002	protein histidine kinase activity
C2H91_16530	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2H91_16530	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2H91_16535	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C2H91_16540	COG1971	Probably functions as a manganese efflux pump
C2H91_16545	COG0237	dephospho-CoA kinase activity
C2H91_16550	COG0656	L-ascorbic acid biosynthetic process
C2H91_16555	COG2814	Major facilitator Superfamily
C2H91_16560	COG1733	regulation of RNA biosynthetic process
C2H91_16565	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2H91_16570	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C2H91_16575	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C2H91_16580	COG3611	Membrane attachment protein
C2H91_16585	COG1484	DNA-dependent DNA replication
C2H91_16590	COG0398	Pfam SNARE associated Golgi protein
C2H91_16600	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2H91_16605	COG1011	Hydrolase
C2H91_16610	COG3275	phosphorelay sensor kinase activity
C2H91_16615	COG3279	Response regulator of the LytR AlgR family
C2H91_16620	COG1380	Effector of murein hydrolase LrgA
C2H91_16625	COG1346	cytolysis
C2H91_16635	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C2H91_16640	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C2H91_16645	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C2H91_16650	COG3326	Membrane
C2H91_16660	COG1363	Peptidase, m42
C2H91_16665	COG3507	Belongs to the glycosyl hydrolase 43 family
C2H91_16670	COG2160	L-arabinose isomerase activity
C2H91_16675	COG1069	ribulokinase activity
C2H91_16680	COG0235	Class ii aldolase
C2H91_16685	COG0647	UMP catabolic process
C2H91_16690	COG0371	Dehydrogenase
C2H91_16695	COG1653	transport
C2H91_16700	COG1175	transmembrane transport
C2H91_16705	COG0395	ABC-type sugar transport system, permease component
C2H91_16710	COG3534	alpha-L-arabinofuranosidase
C2H91_16715	COG1966	Carbon starvation protein
C2H91_16725	COG0346	lactoylglutathione lyase activity
C2H91_16730	COG0247	lactate metabolic process
C2H91_16735	COG0277	FAD linked oxidase domain protein
C2H91_16740	COG3835	regulator
C2H91_16750	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2H91_16760	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C2H91_16765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H91_16765	COG0072	phenylalanine-tRNA ligase activity
C2H91_16770	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2H91_16775	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C2H91_16780	COG1286	toxin biosynthetic process
C2H91_16785	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2H91_16785	COG1796	DNA polymerase
C2H91_16790	COG1193	negative regulation of DNA recombination
C2H91_16795	COG3766	membrane
C2H91_16800	COG0318	PFAM AMP-dependent synthetase and ligase
C2H91_16805	COG1309	transcriptional regulator
C2H91_16810	COG1024	Enoyl-CoA hydratase
C2H91_16815	COG2086	electron transfer activity
C2H91_16820	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C2H91_16825	COG3534	alpha-L-arabinofuranosidase
C2H91_16835	COG3118	belongs to the thioredoxin family
C2H91_16840	COG0322	excinuclease ABC activity
C2H91_16850	COG0527	aspartate kinase activity
C2H91_16855	COG1719	4-vinyl reductase, 4VR
C2H91_16860	COG2009	succinate dehydrogenase
C2H91_16865	COG1053	succinate dehydrogenase
C2H91_16870	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2H91_16875	COG0824	Thioesterase
C2H91_16880	COG2197	response regulator
C2H91_16885	COG1846	Transcriptional regulator
C2H91_16890	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2H91_16895	COG5401	PFAM Sporulation and spore germination
C2H91_16900	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C2H91_16905	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C2H91_16910	COG0622	Phosphoesterase
C2H91_16920	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
C2H91_16930	COG0454	-acetyltransferase
C2H91_16940	COG0028	Belongs to the TPP enzyme family
C2H91_16945	COG0440	acetolactate synthase activity
C2H91_16950	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C2H91_16955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2H91_16960	COG0473	3-isopropylmalate dehydrogenase activity
C2H91_16965	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2H91_16970	COG0066	3-isopropylmalate dehydratase activity
C2H91_16975	COG1477	protein flavinylation
C2H91_16975	COG0457	Tetratricopeptide repeat
C2H91_16980	COG0544	peptidyl-prolyl cis-trans isomerase activity
C2H91_16985	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C2H91_16990	COG1067	ATP-dependent peptidase activity
C2H91_16990	COG0470	DNA polymerase III
C2H91_16995	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2H91_17000	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C2H91_17010	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C2H91_17015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2H91_17020	COG0181	hydroxymethylbilane synthase activity
C2H91_17025	COG1587	Uroporphyrinogen-III synthase
C2H91_17030	COG0113	porphobilinogen synthase activity
C2H91_17035	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2H91_17040	COG1388	LysM domain
C2H91_17045	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H91_17055	COG0525	valine-tRNA ligase activity
C2H91_17060	COG0285	dihydrofolate synthase activity
C2H91_17065	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C2H91_17075	COG0424	maF-like protein
C2H91_17080	COG2003	Belongs to the UPF0758 family
C2H91_17085	COG1077	Cell shape determining protein MreB Mrl
C2H91_17095	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2H91_17100	COG0850	regulation of cytokinetic process
C2H91_17105	COG2894	cell division
C2H91_17110	COG0739	heme binding
C2H91_17115	COG1994	Peptidase M50
C2H91_17120	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C2H91_17125	COG2868	ribosomal protein
C2H91_17130	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C2H91_17135	COG3290	protein histidine kinase activity
C2H91_17140	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C2H91_17145	COG4492	Belongs to the UPF0735 family
C2H91_17150	COG0077	Prephenate dehydratase
C2H91_17155	COG1827	regulation of RNA biosynthetic process
C2H91_17160	COG1104	cysteine desulfurase activity
C2H91_17165	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2H91_17170	COG0157	Belongs to the NadC ModD family
C2H91_17175	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2H91_17180	COG1388	LysM domain
C2H91_17190	COG0217	transcriptional regulatory protein
C2H91_17195	COG1115	amino acid carrier protein
C2H91_17210	COG2112	serine threonine protein kinase
C2H91_17215	COG0673	inositol 2-dehydrogenase activity
C2H91_17220	COG2814	Major facilitator Superfamily
C2H91_17230	COG0632	four-way junction helicase activity
C2H91_17235	COG2255	four-way junction helicase activity
C2H91_17245	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C2H91_17250	COG0343	queuine tRNA-ribosyltransferase activity
C2H91_17255	COG1862	Preprotein translocase
C2H91_17265	COG2323	membrane
C2H91_17270	COG2244	polysaccharide biosynthetic process
C2H91_17280	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2H91_17280	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2H91_17285	COG0490	domain, Protein
C2H91_17290	COG5416	Lipopolysaccharide assembly protein A domain
C2H91_17295	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2H91_17295	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C2H91_17300	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2H91_17305	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2H91_17310	COG1490	D-aminoacyl-tRNA deacylase activity
C2H91_17315	COG3103	Sh3 type 3 domain protein
C2H91_17315	COG4991	sh3 domain protein
C2H91_17315	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H91_17325	COG0124	histidyl-tRNA synthetase
C2H91_17330	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C2H91_17340	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2H91_17345	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2H91_17350	COG1959	2 iron, 2 sulfur cluster binding
C2H91_17355	COG1104	cysteine desulfurase activity
C2H91_17360	COG0482	sulfurtransferase activity
C2H91_17365	COG0457	Tetratricopeptide repeat
C2H91_17370	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2H91_17375	COG3881	PFAM PRC-barrel domain
C2H91_17390	COG0765	amino acid transport
C2H91_17395	COG0765	amino acid transport
C2H91_17400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H91_17405	COG1126	abc transporter atp-binding protein
C2H91_17410	COG0628	permease
C2H91_17415	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2H91_17420	COG4472	Bacterial protein of unknown function (DUF965)
C2H91_17425	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C2H91_17430	COG3906	Belongs to the UPF0473 family
C2H91_17435	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2H91_17440	COG4122	O-methyltransferase activity
C2H91_17445	COG0826	peptidase U32
C2H91_17450	COG0826	peptidase U32
C2H91_17455	COG0572	uridine kinase
C2H91_17460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2H91_17465	COG0768	penicillin binding
C2H91_17480	COG2226	methyltransferase
C2H91_17485	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2H91_17490	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2H91_17495	COG0626	cystathionine gamma-synthase activity
C2H91_17505	COG2427	Protein of unknown function (DUF1641)
C2H91_17510	COG3383	formate dehydrogenase (NAD+) activity
C2H91_17515	COG5609	conserved protein (DUF2294)
C2H91_17520	COG2116	formate transmembrane transporter activity
C2H91_17530	COG2226	methyltransferase
C2H91_17535	COG1309	transcriptional regulator
C2H91_17540	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2H91_17540	COG2124	cytochrome p450
C2H91_17550	COG2755	lipolytic protein G-D-S-L family
C2H91_17550	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C2H91_17560	COG1595	DNA-templated transcription, initiation
C2H91_17570	COG1280	lysine exporter protein (LysE YggA)
C2H91_17575	COG1113	amino acid transport
C2H91_17580	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2H91_17580	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C2H91_17585	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H91_17590	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H91_17595	COG3715	PTS system
C2H91_17600	COG3716	PTS system mannose fructose sorbose family IID component
C2H91_17605	COG1621	beta-fructofuranosidase activity
C2H91_17610	COG0693	protein deglycase activity
C2H91_17615	COG1064	alcohol dehydrogenase
C2H91_17625	COG0789	Transcriptional regulator
C2H91_17630	COG5577	PFAM Coat F domain
C2H91_17640	COG1063	alcohol dehydrogenase
C2H91_17645	COG5577	PFAM Coat F domain
C2H91_17655	COG0346	lactoylglutathione lyase activity
C2H91_17660	COG4991	sh3 domain protein
C2H91_17665	COG4991	sh3 domain protein
C2H91_17670	COG0596	Alpha beta hydrolase
C2H91_17675	COG5566	PFAM Mor transcription activator
C2H91_17680	COG3409	Peptidoglycan-binding domain 1 protein
C2H91_17685	COG2828	Protein conserved in bacteria
C2H91_17690	COG0583	DNA-binding transcription factor activity
C2H91_17695	COG2851	Citrate transporter
C2H91_17700	COG0667	Aldo Keto reductase
C2H91_17705	COG1595	DNA-templated transcription, initiation
C2H91_17710	COG3443	Belongs to the bacterial solute-binding protein 9 family
C2H91_17725	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2H91_17740	COG2070	2-Nitropropane dioxygenase
C2H91_17750	COG2318	DinB family
C2H91_17770	COG1335	isochorismatase
C2H91_17785	COG2124	cytochrome p450
C2H91_17790	COG2732	(Barnase) inhibitor
C2H91_17795	COG1522	sequence-specific DNA binding
C2H91_17800	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C2H91_17805	COG1687	branched-chain amino acid
C2H91_17810	COG1114	Component of the transport system for branched-chain amino acids
C2H91_17820	COG1230	cation diffusion facilitator family transporter
C2H91_17825	COG2072	flavoprotein involved in K transport
C2H91_17830	COG0583	DNA-binding transcription factor activity
C2H91_17835	COG0697	spore germination
C2H91_17845	COG1253	flavin adenine dinucleotide binding
C2H91_17850	COG0456	acetyltransferase
C2H91_17855	COG2814	Major facilitator Superfamily
C2H91_17860	COG0789	Transcriptional regulator
C2H91_17860	COG4978	Transcriptional regulator
C2H91_17880	COG0662	Cupin 2, conserved barrel domain protein
C2H91_17895	COG1937	Protein conserved in bacteria
C2H91_17900	COG2210	Belongs to the sulfur carrier protein TusA family
C2H91_17905	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2H91_17905	COG0425	Belongs to the sulfur carrier protein TusA family
C2H91_17915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H91_17915	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2H91_17920	COG0425	Belongs to the sulfur carrier protein TusA family
C2H91_17925	COG0730	response to heat
C2H91_17935	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2H91_17940	COG0454	-acetyltransferase
C2H91_17945	COG2311	Membrane
C2H91_17950	COG0745	RESPONSE REGULATOR receiver
C2H91_17955	COG0642	Histidine kinase
C2H91_17955	COG5002	protein histidine kinase activity
C2H91_17960	COG3223	Belongs to the PsiE family
C2H91_17980	COG3209	COG3209 Rhs family protein
C2H91_17990	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C2H91_17995	COG0398	Pfam SNARE associated Golgi protein
C2H91_18000	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2H91_18000	COG3409	Peptidoglycan-binding domain 1 protein
C2H91_18005	COG2755	lipolytic protein G-D-S-L family
C2H91_18015	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C2H91_18020	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2H91_18025	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2H91_18030	COG1534	Rna-binding protein
C2H91_18035	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2H91_18040	COG1713	HD superfamily hydrolase involved in NAD metabolism
C2H91_18045	COG0799	negative regulation of ribosome biogenesis
C2H91_18050	COG2226	methyltransferase
C2H91_18055	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2H91_18060	COG1555	photosystem II stabilization
C2H91_18060	COG1596	polysaccharide export
C2H91_18065	COG2131	deaminase
C2H91_18070	COG2333	competence protein COMEC
C2H91_18070	COG0658	competence protein
C2H91_18080	COG1466	dna polymerase III delta subunit
C2H91_18085	COG0268	Binds directly to 16S ribosomal RNA
C2H91_18090	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C2H91_18095	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H91_18105	COG0481	GTPase activity
C2H91_18110	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2H91_18115	COG1420	regulation of RNA biosynthetic process
C2H91_18120	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C2H91_18125	COG0443	Heat shock 70 kDa protein
C2H91_18130	COG0484	heat shock protein binding
C2H91_18135	COG2264	protein methyltransferase activity
C2H91_18140	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2H91_18145	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2H91_18150	COG1283	sodium-dependent phosphate transmembrane transporter activity
C2H91_18160	COG1610	YqeY-like protein
C2H91_18165	COG1030	water channel activity
C2H91_18170	COG4864	UPF0365 protein
C2H91_18185	COG0561	phosphatase activity
C2H91_18190	COG1702	phosphate starvation-inducible protein PhoH
C2H91_18195	COG1480	7TM receptor with intracellular HD hydrolase
C2H91_18200	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C2H91_18205	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2H91_18210	COG0295	cytidine deaminase activity
C2H91_18215	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C2H91_18225	COG1381	Involved in DNA repair and RecF pathway recombination
C2H91_18230	COG0752	glycyl-tRNA synthetase alpha subunit
C2H91_18235	COG0751	glycine-tRNA ligase activity
C2H91_18240	COG0517	IMP dehydrogenase activity
C2H91_18245	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C2H91_18250	COG1671	Belongs to the UPF0178 family
C2H91_18255	COG0358	DNA primase activity
C2H91_18260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2H91_18270	COG2010	Cytochrome c
C2H91_18275	COG2384	SAM-dependent methyltransferase
C2H91_18280	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2H91_18285	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C2H91_18295	COG0513	Belongs to the DEAD box helicase family
C2H91_18300	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C2H91_18310	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H91_18315	COG0735	belongs to the Fur family
C2H91_18320	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
C2H91_18325	COG4709	membrane
C2H91_18330	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C2H91_18335	COG1388	LysM domain
C2H91_18345	COG5521	maltodextrose utilization protein MalA
C2H91_18350	COG2839	Protein conserved in bacteria
C2H91_18355	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2H91_18360	COG0477	Major facilitator Superfamily
C2H91_18365	COG0768	penicillin binding
C2H91_18370	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2H91_18375	COG0573	inorganic phosphate transmembrane transporter activity
C2H91_18380	COG0581	inorganic phosphate transmembrane transporter activity
C2H91_18385	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2H91_18390	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2H91_18395	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2H91_18410	COG0438	transferase activity, transferring glycosyl groups
C2H91_18420	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2H91_18430	COG0705	Rhomboid family
C2H91_18430	COG0457	Tetratricopeptide repeat
C2H91_18435	COG4483	Protein conserved in bacteria
C2H91_18440	COG1940	carbohydrate kinase activity
C2H91_18445	COG1368	sulfuric ester hydrolase activity
C2H91_18450	COG2866	Carboxypeptidase
C2H91_18460	COG0011	TIGRFAM Protein of
C2H91_18470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H91_18480	COG1393	Belongs to the ArsC family
C2H91_18490	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H91_18495	COG1253	flavin adenine dinucleotide binding
C2H91_18500	COG0598	Magnesium transport protein CorA
C2H91_18505	COG0517	IMP dehydrogenase activity
C2H91_18510	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2H91_18515	COG1459	type II secretion system
C2H91_18520	COG4537	Required for transformation and DNA binding
C2H91_18525	COG4970	Tfp pilus assembly protein FimT
C2H91_18535	COG4940	Competence protein ComGF
C2H91_18560	COG0681	Belongs to the peptidase S26 family
C2H91_18570	COG1396	sequence-specific DNA binding
C2H91_18590	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2H91_18595	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2H91_18600	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2H91_18605	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2H91_18610	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2H91_18615	COG0095	Lipoate-protein ligase
C2H91_18620	COG1321	iron dependent repressor
C2H91_18625	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2H91_18635	COG3872	metal-dependent enzyme
C2H91_18645	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C2H91_18650	COG0006	proline dipeptidase activity
C2H91_18655	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C2H91_18665	COG3854	ATPases associated with a variety of cellular activities
C2H91_18705	COG0511	ligase activity, forming carbon-carbon bonds
C2H91_18710	COG0439	Biotin carboxylase
C2H91_18715	COG1302	Protein conserved in bacteria
C2H91_18720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2H91_18725	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C2H91_18730	COG1570	exodeoxyribonuclease VII activity
C2H91_18735	COG1722	exodeoxyribonuclease VII activity
C2H91_18740	COG0142	geranyltranstransferase activity
C2H91_18745	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2H91_18750	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C2H91_18755	COG1438	arginine binding
C2H91_18760	COG0497	DNA recombination
C2H91_18765	COG0750	zinc metalloprotease
C2H91_18770	COG0745	RESPONSE REGULATOR receiver
C2H91_18775	COG1902	pentaerythritol trinitrate reductase activity
C2H91_18785	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H91_18790	COG0584	glycerophosphoryl diester phosphodiesterase
C2H91_18800	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2H91_18805	COG1960	acyl-CoA dehydrogenase activity
C2H91_18810	COG0372	Belongs to the citrate synthase family
C2H91_18815	COG2079	MmgE PrpD family protein
C2H91_18820	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C2H91_18830	COG3829	transcription factor binding
C2H91_18830	COG3290	protein histidine kinase activity
C2H91_18835	COG0280	phosphate acetyltransferase
C2H91_18840	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2H91_18845	COG3426	butyrate kinase activity
C2H91_18850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2H91_18855	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2H91_18860	COG0022	dehydrogenase e1 component
C2H91_18865	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H91_18870	COG0789	Transcriptional regulator
C2H91_18870	COG4978	Transcriptional regulator
C2H91_18875	COG2814	Major facilitator Superfamily
C2H91_18880	COG1597	lipid kinase activity
C2H91_18890	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H91_18895	COG0765	amino acid transport
C2H91_18900	COG1126	abc transporter atp-binding protein
C2H91_18905	COG4129	membrane
C2H91_18910	COG1376	ErfK ybiS ycfS ynhG family protein
C2H91_18915	COG0346	lactoylglutathione lyase activity
C2H91_18920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2H91_18925	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2H91_18930	COG3361	conserved protein (COG2071)
C2H91_18935	COG0706	membrane insertase activity
C2H91_18945	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2H91_18950	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C2H91_18955	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2H91_18960	COG1234	tRNA 3'-trailer cleavage
C2H91_18970	COG0596	Alpha beta hydrolase
C2H91_18975	COG1902	pentaerythritol trinitrate reductase activity
C2H91_18980	COG4187	Peptidase family M20/M25/M40
C2H91_18985	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2H91_18990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H91_18995	COG0300	oxidoreductase activity
C2H91_19000	COG3048	D-serine ammonia-lyase activity
C2H91_19005	COG1072	(Pantothenic acid kinase))
C2H91_19020	COG2211	Major facilitator Superfamily
C2H91_19030	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2H91_19040	COG0456	acetyltransferase
C2H91_19045	COG2329	Antibiotic biosynthesis monooxygenase
C2H91_19050	COG0456	acetyltransferase
C2H91_19050	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2H91_19055	COG4918	Iron-sulphur cluster biosynthesis
C2H91_19065	COG1073	alpha beta
C2H91_19075	COG0667	Aldo Keto reductase
C2H91_19085	COG0494	nUDIX hydrolase
C2H91_19090	COG1379	DNA repair
C2H91_19095	COG1396	sequence-specific DNA binding
C2H91_19100	COG0252	asparaginase activity
C2H91_19105	COG1027	Aspartate ammonia-lyase
C2H91_19110	COG1757	Na H antiporter
C2H91_19115	COG0281	malic enzyme
C2H91_19125	COG1300	Membrane
C2H91_19130	COG0735	belongs to the Fur family
C2H91_19140	COG4974	Belongs to the 'phage' integrase family
C2H91_19145	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C2H91_19150	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C2H91_19155	COG1686	Belongs to the peptidase S11 family
C2H91_19160	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H91_19165	COG2172	sigma factor antagonist activity
C2H91_19170	COG1191	sigma factor activity
C2H91_19190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2H91_19205	COG0697	spore germination
C2H91_19210	COG0019	diaminopimelate decarboxylase activity
C2H91_19215	COG4086	secreted protein
C2H91_19225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2H91_19235	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
C2H91_19240	COG0681	Belongs to the peptidase S26 family
C2H91_19250	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2H91_19250	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2H91_19255	COG0307	riboflavin synthase, alpha
C2H91_19260	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2H91_19260	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2H91_19265	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C2H91_19270	COG0456	acetyltransferase
C2H91_19275	COG1547	Domain of unknown function (DUF309)
C2H91_19280	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C2H91_19285	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C2H91_19295	COG1686	Belongs to the peptidase S11 family
C2H91_19300	COG2715	membrane protein required for spore maturation
C2H91_19305	COG0700	Nucleoside recognition
C2H91_19310	COG1187	pseudouridine synthase activity
C2H91_19315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H91_19320	COG1333	cytochrome c biogenesis protein
C2H91_19325	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2H91_19330	COG0745	RESPONSE REGULATOR receiver
C2H91_19335	COG5002	protein histidine kinase activity
C2H91_19340	COG1595	DNA-templated transcription, initiation
C2H91_19350	COG0710	3-dehydroquinate dehydratase activity
C2H91_19355	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2H91_19360	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C2H91_19365	COG1141	Ferredoxin
C2H91_19370	COG4955	Helix-turn-helix domain
C2H91_19375	COG0514	ATP-dependent DNA helicase (RecQ)
C2H91_19380	COG1266	CAAX protease self-immunity
C2H91_19385	COG1388	LysM domain
C2H91_19395	COG1408	metallophosphoesterase
C2H91_19400	COG4862	establishment of competence for transformation
C2H91_19405	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2H91_19410	COG0492	ferredoxin-NADP+ reductase activity
C2H91_19415	COG2339	peptidase activity
C2H91_19420	COG3773	Cell wall hydrolase
C2H91_19420	COG3409	Peptidoglycan-binding domain 1 protein
C2H91_19425	COG2959	enzyme of heme biosynthesis
C2H91_19430	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C2H91_19440	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C2H91_19445	COG0539	negative regulation of cytoplasmic translation
C2H91_19450	COG1304	FMN binding
C2H91_19475	COG1160	GTP binding
C2H91_19480	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C2H91_19495	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2H91_19500	COG0776	regulation of translation
C2H91_19505	COG0302	gtp cyclohydrolase
C2H91_19515	COG0142	geranyltranstransferase activity
C2H91_19520	COG2226	methyltransferase
C2H91_19525	COG0142	geranyltranstransferase activity
C2H91_19530	COG0105	UTP biosynthetic process
C2H91_19535	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2H91_19540	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C2H91_19545	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C2H91_19550	COG4401	Chorismate mutase type I
C2H91_19555	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2H91_19560	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2H91_19570	COG0135	phosphoribosylanthranilate isomerase activity
C2H91_19575	COG0133	tryptophan synthase activity
C2H91_19580	COG0159	tryptophan synthase activity
C2H91_19590	COG0287	Prephenate dehydrogenase
C2H91_19595	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C2H91_19600	COG0457	Tetratricopeptide repeat
C2H91_19605	COG5582	Belongs to the UPF0302 family
C2H91_19615	COG0723	plastoquinol--plastocyanin reductase activity
C2H91_19620	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2H91_19625	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2H91_19625	COG2010	Cytochrome c
C2H91_19630	COG4347	Protein of unknown function (DUF1405)
C2H91_19640	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H91_19645	COG1694	Mazg nucleotide pyrophosphohydrolase
C2H91_19650	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C2H91_19655	COG1803	Methylglyoxal synthase
C2H91_19660	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2H91_19665	COG0438	transferase activity, transferring glycosyl groups
C2H91_19670	COG0617	tRNA 3'-terminal CCA addition
C2H91_19675	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C2H91_19675	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C2H91_19680	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C2H91_19685	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C2H91_19690	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C2H91_19695	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2H91_19695	COG1199	ATP-dependent helicase activity
C2H91_19705	COG5353	protein conserved in bacteria
C2H91_19710	COG0436	Aminotransferase
C2H91_19715	COG0017	Asparaginyl-tRNA synthetase
C2H91_19720	COG3935	DnaD domain protein
C2H91_19725	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2H91_19735	COG4499	WXG100 protein secretion system (Wss), protein YukC
C2H91_19735	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2H91_19740	COG3331	DNA recombination
C2H91_19775	COG0071	Belongs to the small heat shock protein (HSP20) family
C2H91_19780	COG2190	(PTS) system
C2H91_19785	COG1111	helicase
C2H91_19785	COG1205	dead DEAH box helicase
C2H91_19790	COG3359	exonuclease
C2H91_19800	COG4474	Belongs to the UPF0398 family
C2H91_19815	COG0116	Belongs to the methyltransferase superfamily
C2H91_19830	COG1199	ATP-dependent helicase activity
C2H91_19835	COG1028	Short-chain dehydrogenase reductase Sdr
C2H91_19840	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C2H91_19845	COG1609	Transcriptional regulator
C2H91_19850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H91_19855	COG0800	Aldolase
C2H91_19865	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C2H91_19870	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2H91_19875	COG2233	PERMEase
C2H91_19880	COG3424	synthase
C2H91_19885	COG1755	Isoprenylcysteine carboxyl methyltransferase
C2H91_19895	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2H91_19910	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2H91_19920	COG0328	RNA-DNA hybrid ribonuclease activity
C2H91_19925	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2H91_19930	COG0328	RNA-DNA hybrid ribonuclease activity
C2H91_19950	COG1278	Cold shock
C2H91_19955	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2H91_19960	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C2H91_19965	COG0386	Belongs to the glutathione peroxidase family
C2H91_19970	COG1418	mRNA catabolic process
C2H91_19975	COG1413	lyase activity
C2H91_19980	COG0129	dihydroxy-acid dehydratase activity
C2H91_19990	COG2521	methyltransferase
C2H91_19990	COG2136	Putative SAM-dependent methyltransferase
C2H91_20000	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2H91_20005	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2H91_20010	COG0204	Acyl-transferase
C2H91_20015	COG1272	protein, Hemolysin III
C2H91_20020	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2H91_20025	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2H91_20035	COG1999	signal sequence binding
C2H91_20040	COG2755	lipolytic protein G-D-S-L family
C2H91_20045	COG4698	Protein conserved in bacteria
C2H91_20055	COG0534	Mate efflux family protein
C2H91_20060	COG1846	Transcriptional regulator
C2H91_20065	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2H91_20070	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2H91_20075	COG1086	Polysaccharide biosynthesis protein
C2H91_20080	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
C2H91_20085	COG4641	Protein conserved in bacteria
C2H91_20100	COG0463	Glycosyl transferase, family 2
C2H91_20105	COG0456	acetyltransferase
C2H91_20115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2H91_20120	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2H91_20125	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2H91_20130	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2H91_20135	COG0456	acetyltransferase
C2H91_20140	COG1509	lysine 2,3-aminomutase activity
C2H91_20150	COG4479	Belongs to the UPF0346 family
C2H91_20175	COG0671	phosphoesterase, PA-phosphatase related
C2H91_20190	COG0813	purine-nucleoside phosphorylase activity
C2H91_20195	COG1876	peptidase activity
C2H91_20205	COG2226	methyltransferase
C2H91_20210	COG0793	Belongs to the peptidase S41A family
C2H91_20210	COG3409	Peptidoglycan-binding domain 1 protein
C2H91_20215	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H91_20225	COG0346	lactoylglutathione lyase activity
C2H91_20230	COG0400	carboxylic ester hydrolase activity
C2H91_20235	COG0778	Nitroreductase
C2H91_20240	COG1733	regulation of RNA biosynthetic process
C2H91_20245	COG1942	4-Oxalocrotonate Tautomerase
C2H91_20265	COG2962	Rard protein
C2H91_20275	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2H91_20280	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2H91_20285	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H91_20290	COG0534	Mate efflux family protein
C2H91_20295	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C2H91_20300	COG1819	glycosyl
C2H91_20305	COG0791	NLP P60 protein
C2H91_20305	COG1388	LysM domain
C2H91_20310	COG2032	superoxide dismutase activity
C2H91_20315	COG0714	Associated with various cellular activities
C2H91_20320	COG4548	von Willebrand factor, type A
C2H91_20325	COG0567	Dehydrogenase, E1 component
C2H91_20330	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H91_20335	COG0385	Bile acid
C2H91_20340	COG0733	neurotransmitter:sodium symporter activity
C2H91_20345	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2H91_20350	COG1657	PFAM Prenyltransferase squalene oxidase
C2H91_20355	COG1012	belongs to the aldehyde dehydrogenase family
C2H91_20380	COG0071	Belongs to the small heat shock protein (HSP20) family
C2H91_20395	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2H91_20400	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2H91_20415	COG0514	ATP-dependent DNA helicase (RecQ)
C2H91_20420	COG3584	3D domain protein
C2H91_20420	COG1388	LysM domain
C2H91_20425	COG2197	response regulator
C2H91_20430	COG4585	Histidine kinase
C2H91_20435	COG3239	Fatty acid desaturase
C2H91_20440	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2H91_20455	COG2322	membrane
C2H91_20460	COG0741	lytic transglycosylase activity
C2H91_20465	COG0640	Transcriptional regulator
C2H91_20475	COG2378	regulation of single-species biofilm formation
C2H91_20480	COG3708	Transcriptional regulator
C2H91_20485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H91_20490	COG1309	transcriptional regulator
C2H91_20495	COG0456	acetyltransferase
C2H91_20500	COG0662	Cupin 2, conserved barrel domain protein
C2H91_20500	COG2207	Transcriptional regulator
C2H91_20505	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H91_20510	COG1231	oxidoreductase activity
C2H91_20520	COG5444	nuclease activity
C2H91_20550	COG0726	polysaccharide deacetylase
C2H91_20555	COG0574	Belongs to the PEP-utilizing enzyme family
C2H91_20555	COG3848	Pyruvate phosphate dikinase
C2H91_20575	COG2367	Beta-lactamase
C2H91_20580	COG0693	protein deglycase activity
C2H91_20590	COG0697	spore germination
C2H91_20595	COG0583	DNA-binding transcription factor activity
C2H91_20600	COG3739	integral membrane protein
C2H91_20605	COG3655	Transcriptional regulator
C2H91_20615	COG2720	vancomycin resistance protein
C2H91_20635	COG2140	Oxalate decarboxylase
C2H91_20645	COG2135	peptidase activity
C2H91_20650	COG3866	Pectate lyase
C2H91_20655	COG3619	membrane
C2H91_20660	COG4305	rare lipoprotein A
C2H91_20665	COG2368	4-hydroxyphenylacetate
C2H91_20670	COG0840	transmembrane signaling receptor activity
C2H91_20670	COG5278	phosphoserine phosphatase activity
C2H91_20695	COG0243	molybdopterin cofactor binding
C2H91_20700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2H91_20705	COG1070	Carbohydrate kinase
C2H91_20710	COG2814	Major facilitator Superfamily
C2H91_20715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H91_20725	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
C2H91_20730	COG0300	oxidoreductase activity
C2H91_20740	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2H91_20745	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C2H91_20750	COG0583	DNA-binding transcription factor activity
C2H91_20755	COG0067	glutamate synthase
C2H91_20755	COG0069	glutamate synthase activity
C2H91_20755	COG0070	glutamate synthase
C2H91_20760	COG0493	'glutamate synthase
C2H91_20765	COG0604	alcohol dehydrogenase