locus-tag	class	description
C2H95_00005	COG0574	Belongs to the PEP-utilizing enzyme family
C2H95_00005	COG3848	Pyruvate phosphate dikinase
C2H95_00010	COG1309	transcriptional regulator
C2H95_00015	COG2814	Major facilitator Superfamily
C2H95_00020	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H95_00030	COG0793	Belongs to the peptidase S41A family
C2H95_00030	COG3409	Peptidoglycan-binding domain 1 protein
C2H95_00035	COG2177	Part of the ABC transporter FtsEX involved in
C2H95_00040	COG2884	Cell division ATP-binding protein ftsE
C2H95_00045	COG2010	Cytochrome c
C2H95_00050	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H95_00060	COG0653	protein targeting
C2H95_00065	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2H95_00080	COG1516	flagellar protein fliS
C2H95_00085	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C2H95_00090	COG1334	flagellar protein FlaG
C2H95_00095	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2H95_00100	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C2H95_00105	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
C2H95_00115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2H95_00120	COG4786	Flagellar basal body rod
C2H95_00120	COG1256	bacterial-type flagellum assembly
C2H95_00125	COG3418	PFAM FlgN family protein
C2H95_00130	COG2747	anti-sigma28 factor FlgM
C2H95_00140	COG1040	competence protein
C2H95_00150	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C2H95_00155	COG1307	EDD domain protein, DegV family
C2H95_00160	COG2197	response regulator
C2H95_00165	COG4585	Histidine kinase
C2H95_00170	COG1739	Uncharacterized protein family UPF0029
C2H95_00175	COG1316	TRANSCRIPTIONal
C2H95_00180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2H95_00185	COG0438	transferase activity, transferring glycosyl groups
C2H95_00190	COG1215	transferase activity, transferring glycosyl groups
C2H95_00195	COG3206	protein involved in exopolysaccharide biosynthesis
C2H95_00200	COG3307	-O-antigen
C2H95_00205	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C2H95_00210	COG0297	glycogen (starch) synthase activity
C2H95_00210	COG0438	transferase activity, transferring glycosyl groups
C2H95_00215	COG2244	polysaccharide biosynthetic process
C2H95_00230	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H95_00230	COG2247	cell wall binding repeat
C2H95_00235	COG2385	sporulation resulting in formation of a cellular spore
C2H95_00235	COG2247	cell wall binding repeat
C2H95_00245	COG1316	TRANSCRIPTIONal
C2H95_00250	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2H95_00270	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2H95_00275	COG1134	teichoic acid transport
C2H95_00280	COG1682	transport, permease protein
C2H95_00290	COG0463	Glycosyl transferase, family 2
C2H95_00335	COG4193	domain, Protein
C2H95_00340	COG1482	cell wall glycoprotein biosynthetic process
C2H95_00345	COG0697	spore germination
C2H95_00350	COG0814	amino acid
C2H95_00360	COG2814	Major facilitator Superfamily
C2H95_00365	COG1316	TRANSCRIPTIONal
C2H95_00370	COG0561	phosphatase activity
C2H95_00375	COG0791	NLP P60 protein
C2H95_00385	COG2843	Capsule synthesis protein
C2H95_00395	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2H95_00400	COG1609	Transcriptional regulator
C2H95_00405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H95_00410	COG1869	D-ribose catabolic process
C2H95_00415	COG1129	ABC transporter
C2H95_00420	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2H95_00425	COG1879	ABC-type sugar transport system periplasmic component
C2H95_00430	COG3103	Sh3 type 3 domain protein
C2H95_00440	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2H95_00445	COG3527	Alpha-acetolactate decarboxylase
C2H95_00450	COG0028	Belongs to the TPP enzyme family
C2H95_00455	COG0583	DNA-binding transcription factor activity
C2H95_00460	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2H95_00475	COG5337	Spore coat protein CotH
C2H95_00485	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2H95_00495	COG0405	Gamma-glutamyltransferase
C2H95_00500	COG1522	sequence-specific DNA binding
C2H95_00505	COG2059	Chromate
C2H95_00510	COG2059	Chromate
C2H95_00515	COG1515	deoxyribonuclease V activity
C2H95_00525	COG5444	nuclease activity
C2H95_00540	COG3878	Protein conserved in bacteria
C2H95_00545	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C2H95_00550	COG4464	protein tyrosine phosphatase activity
C2H95_00555	COG0489	protein tyrosine kinase activity
C2H95_00560	COG3944	biosynthesis protein
C2H95_00570	COG4715	Zinc finger, swim domain protein
C2H95_00575	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2H95_00580	COG0561	phosphatase activity
C2H95_00585	COG1349	DNA-binding transcription factor activity
C2H95_00590	COG0629	single-stranded DNA binding
C2H95_00605	COG3764	Sortase (surface protein transpeptidase)
C2H95_00615	COG3279	Response regulator of the LytR AlgR family
C2H95_00620	COG2972	Histidine kinase
C2H95_00620	COG0745	RESPONSE REGULATOR receiver
C2H95_00625	COG1970	mechanosensitive ion channel activity
C2H95_00630	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2H95_00635	COG0457	Tetratricopeptide repeat
C2H95_00640	COG4786	Flagellar basal body rod
C2H95_00645	COG4786	Flagellar basal body rod
C2H95_00650	COG1077	Cell shape determining protein MreB Mrl
C2H95_00655	COG1609	Transcriptional regulator
C2H95_00665	COG1846	Transcriptional regulator
C2H95_00670	COG2814	Major facilitator Superfamily
C2H95_00675	COG3420	alginic acid biosynthetic process
C2H95_00680	COG1953	Uracil, thiamine, allantoin
C2H95_00685	COG0477	Major facilitator Superfamily
C2H95_00690	COG1335	isochorismatase
C2H95_00700	COG0004	ammonium transporteR
C2H95_00705	COG0347	Belongs to the P(II) protein family
C2H95_00710	COG0671	phosphoesterase, PA-phosphatase related
C2H95_00720	COG0739	heme binding
C2H95_00725	COG1247	-acetyltransferase
C2H95_00740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2H95_00745	COG0789	Transcriptional regulator
C2H95_00755	COG2910	NAD(P)H-binding
C2H95_00760	COG1959	2 iron, 2 sulfur cluster binding
C2H95_00765	COG0804	urea catabolic process
C2H95_00770	COG0832	Belongs to the urease beta subunit family
C2H95_00775	COG0831	urea catabolic process
C2H95_00790	COG3237	CsbD-like
C2H95_00795	COG1994	Peptidase M50
C2H95_00800	COG0457	Tetratricopeptide repeat
C2H95_00805	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2H95_00810	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2H95_00820	COG2304	oxidoreductase activity
C2H95_00830	COG2304	oxidoreductase activity
C2H95_00835	COG2385	sporulation resulting in formation of a cellular spore
C2H95_00840	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2H95_00850	COG4836	Membrane
C2H95_00860	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C2H95_00865	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C2H95_00870	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C2H95_00875	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C2H95_00880	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2H95_00895	COG0356	it plays a direct role in the translocation of protons across the membrane
C2H95_00905	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C2H95_00910	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2H95_00915	COG4475	Protein of unknown function (DUF436)
C2H95_00920	COG0698	ribose 5-phosphate isomerase
C2H95_00925	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2H95_00930	COG1971	Probably functions as a manganese efflux pump
C2H95_00935	COG0009	L-threonylcarbamoyladenylate synthase
C2H95_00940	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2H95_00960	COG2890	protein-(glutamine-N5) methyltransferase activity
C2H95_00965	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C2H95_00970	COG0346	lactoylglutathione lyase activity
C2H95_00975	COG0789	Transcriptional regulator
C2H95_00980	COG0679	Auxin Efflux Carrier
C2H95_00985	COG0281	malic enzyme
C2H95_00990	COG1435	thymidine kinase activity
C2H95_01000	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2H95_01005	COG1494	fructose-1,6-bisphosphatase
C2H95_01010	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2H95_01015	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2H95_01020	COG0191	fructose-bisphosphate aldolase activity
C2H95_01025	COG2204	response regulator
C2H95_01030	COG4821	SIS domain
C2H95_01035	COG0504	CTP synthase activity
C2H95_01040	COG3343	RNA polymerase activity
C2H95_01045	COG1960	acyl-CoA dehydrogenase activity
C2H95_01050	COG0247	lactate metabolic process
C2H95_01050	COG2181	nitrate reductase activity
C2H95_01055	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2H95_01060	COG4294	response to UV
C2H95_01070	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2H95_01075	COG1132	(ABC) transporter
C2H95_01080	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2H95_01090	COG2181	nitrate reductase activity
C2H95_01095	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2H95_01100	COG1140	nitrate reductase beta subunit
C2H95_01105	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2H95_01110	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2H95_01120	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2H95_01125	COG2223	nitrite transmembrane transporter activity
C2H95_01130	COG0018	arginyl-trna synthetase
C2H95_01135	COG4506	Protein conserved in bacteria
C2H95_01150	COG0535	radical SAM domain protein
C2H95_01160	COG1131	(ABC) transporter
C2H95_01165	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C2H95_01170	COG0612	Peptidase, M16
C2H95_01175	COG0612	Peptidase, M16
C2H95_01185	COG3391	amine dehydrogenase activity
C2H95_01190	COG3391	amine dehydrogenase activity
C2H95_01200	COG0457	Tetratricopeptide repeat
C2H95_01215	COG0010	Belongs to the arginase family
C2H95_01220	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C2H95_01225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2H95_01240	COG1994	Peptidase M50
C2H95_01245	COG1942	4-Oxalocrotonate Tautomerase
C2H95_01250	COG1846	Transcriptional regulator
C2H95_01255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2H95_01260	COG0477	Major facilitator Superfamily
C2H95_01265	COG1959	2 iron, 2 sulfur cluster binding
C2H95_01270	COG3465	dGTPase activity
C2H95_01275	COG1078	dGTPase activity
C2H95_01280	COG4844	belongs to the
C2H95_01290	COG0697	spore germination
C2H95_01295	COG0095	Lipoate-protein ligase
C2H95_01300	COG0583	DNA-binding transcription factor activity
C2H95_01305	COG0280	phosphate acetyltransferase
C2H95_01310	COG3253	May function as heme-dependent peroxidase
C2H95_01315	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_01320	COG0436	Aminotransferase
C2H95_01325	COG2814	Major facilitator Superfamily
C2H95_01330	COG0151	Belongs to the GarS family
C2H95_01335	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_01340	COG1917	Cupin 2, conserved barrel domain protein
C2H95_01345	COG0077	Prephenate dehydratase
C2H95_01350	COG2814	Major facilitator Superfamily
C2H95_01360	COG4187	Peptidase family M20/M25/M40
C2H95_01365	COG1012	belongs to the aldehyde dehydrogenase family
C2H95_01370	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2H95_01380	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C2H95_01385	COG1091	dTDP-4-dehydrorhamnose reductase activity
C2H95_01390	COG1088	dTDP-glucose 4,6-dehydratase activity
C2H95_01395	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C2H95_01400	COG3980	spore coat polysaccharide biosynthesis protein
C2H95_01405	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
C2H95_01410	COG2089	acid synthase
C2H95_01415	COG0456	acetyltransferase
C2H95_01420	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2H95_01425	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C2H95_01430	COG0463	Glycosyl transferase, family 2
C2H95_01445	COG2363	Small membrane protein
C2H95_01450	COG2233	PERMEase
C2H95_01460	COG1012	belongs to the aldehyde dehydrogenase family
C2H95_01465	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C2H95_01470	COG1216	Glycosyl transferase, family 2
C2H95_01485	COG1695	Transcriptional regulator
C2H95_01490	COG0351	phosphomethylpyrimidine kinase
C2H95_01505	COG1621	beta-fructofuranosidase activity
C2H95_01510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H95_01510	COG1263	PTS System
C2H95_01515	COG2116	formate transmembrane transporter activity
C2H95_01520	COG3711	transcriptional antiterminator
C2H95_01530	COG1404	Belongs to the peptidase S8 family
C2H95_01535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H95_01540	COG0778	Nitroreductase
C2H95_01545	COG0772	Belongs to the SEDS family
C2H95_01560	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2H95_01565	COG1845	cytochrome c oxidase, subunit III
C2H95_01570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2H95_01575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2H95_01580	COG2261	transglycosylase associated protein
C2H95_01585	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C2H95_01590	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C2H95_01595	COG2246	polysaccharide biosynthetic process
C2H95_01600	COG1309	transcriptional regulator
C2H95_01610	COG3162	membrane
C2H95_01615	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H95_01620	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C2H95_01625	COG2837	iron assimilation
C2H95_01630	COG2822	iron ion transport
C2H95_01635	COG0672	)-iron permease
C2H95_01645	COG0352	thiamine-phosphate diphosphorylase activity
C2H95_01650	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C2H95_01655	COG0583	DNA-binding transcription factor activity
C2H95_01660	COG1380	Effector of murein hydrolase LrgA
C2H95_01665	COG1346	cytolysis
C2H95_01670	COG2814	Major facilitator Superfamily
C2H95_01675	COG4895	conserved protein (DUF2196)
C2H95_01685	COG0346	lactoylglutathione lyase activity
C2H95_01695	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H95_01700	COG1404	Belongs to the peptidase S8 family
C2H95_01705	COG1263	PTS System
C2H95_01705	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H95_01710	COG3711	transcriptional antiterminator
C2H95_01715	COG1442	glycosyl transferase family 8
C2H95_01720	COG5522	Integral membrane protein (intg_mem_TP0381)
C2H95_01725	COG1846	Transcriptional regulator
C2H95_01730	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2H95_01735	COG2234	aminopeptidase activity
C2H95_01750	COG2814	Major facilitator Superfamily
C2H95_01755	COG2357	RelA SpoT domain protein
C2H95_01760	COG1575	Belongs to the MenA family. Type 1 subfamily
C2H95_01775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H95_01780	COG1696	Membrane protein involved in D-alanine export
C2H95_01785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H95_01790	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C2H95_01795	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
C2H95_01800	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2H95_01805	COG1486	melibiose metabolic process
C2H95_01810	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2H95_01815	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H95_01820	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H95_01825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H95_01825	COG3711	transcriptional antiterminator
C2H95_01835	COG2094	Belongs to the DNA glycosylase MPG family
C2H95_01840	COG0753	catalase activity
C2H95_01845	COG2814	Major facilitator Superfamily
C2H95_01850	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2H95_01855	COG1131	(ABC) transporter
C2H95_01875	COG1595	DNA-templated transcription, initiation
C2H95_01880	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2H95_01885	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2H95_01890	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2H95_01895	COG4988	ABC transporter
C2H95_01900	COG1294	oxidase, subunit
C2H95_01905	COG1271	oxidase subunit
C2H95_01910	COG3493	citrate carrier protein
C2H95_01915	COG0501	Belongs to the peptidase M48B family
C2H95_01925	COG0726	polysaccharide deacetylase
C2H95_01940	COG3842	ATPase activity
C2H95_01945	COG2508	Transcriptional regulator
C2H95_01950	COG1012	belongs to the aldehyde dehydrogenase family
C2H95_01955	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H95_01970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2H95_01980	COG4585	Histidine kinase
C2H95_01985	COG2197	response regulator
C2H95_01990	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2H95_02000	COG4894	glucomannan catabolic process
C2H95_02005	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2H95_02010	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2H95_02015	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_02020	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2H95_02025	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2H95_02030	COG2610	gluconate transmembrane transporter activity
C2H95_02035	COG0500	methyltransferase
C2H95_02040	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2H95_02055	COG0753	catalase activity
C2H95_02055	COG0693	protein deglycase activity
C2H95_02060	COG2851	Citrate transporter
C2H95_02065	COG2273	Hydrolase Family 16
C2H95_02070	COG3711	transcriptional antiterminator
C2H95_02080	COG2270	Major facilitator Superfamily
C2H95_02085	COG0513	Belongs to the DEAD box helicase family
C2H95_02090	COG2755	lipolytic protein G-D-S-L family
C2H95_02090	COG3401	FG-GAP repeat protein
C2H95_02160	COG3209	COG3209 Rhs family protein
C2H95_02165	COG0697	spore germination
C2H95_02170	COG0589	response to stress
C2H95_02175	COG2723	6-phospho-beta-galactosidase activity
C2H95_02180	COG1263	PTS System
C2H95_02180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H95_02180	COG2190	(PTS) system
C2H95_02225	COG3507	Belongs to the glycosyl hydrolase 43 family
C2H95_02240	COG2986	histidine ammonia-lyase
C2H95_02245	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C2H95_02250	COG1228	amidohydrolase
C2H95_02255	COG0010	Belongs to the arginase family
C2H95_02260	COG0833	amino acid
C2H95_02265	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C2H95_02270	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2H95_02275	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C2H95_02280	COG2390	Transcriptional regulator
C2H95_02290	COG3192	ethanolamine utilization protein
C2H95_02295	COG2079	MmgE PrpD family protein
C2H95_02300	COG1473	amidohydrolase
C2H95_02305	COG1126	abc transporter atp-binding protein
C2H95_02310	COG0765	amino acid transport
C2H95_02315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H95_02320	COG0456	acetyltransferase
C2H95_02325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H95_02335	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C2H95_02340	COG0561	phosphatase activity
C2H95_02370	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H95_02375	COG5294	Protein conserved in bacteria
C2H95_02380	COG0577	efflux transmembrane transporter activity
C2H95_02385	COG1136	(ABC) transporter
C2H95_02390	COG2205	protein histidine kinase activity
C2H95_02395	COG0745	RESPONSE REGULATOR receiver
C2H95_02400	COG0191	fructose-bisphosphate aldolase activity
C2H95_02405	COG1082	Xylose isomerase domain protein TIM barrel
C2H95_02410	COG1082	Xylose isomerase domain protein TIM barrel
C2H95_02415	COG0673	inositol 2-dehydrogenase activity
C2H95_02420	COG2814	Major facilitator Superfamily
C2H95_02425	COG1082	Xylose isomerase domain protein TIM barrel
C2H95_02430	COG3962	Belongs to the TPP enzyme family
C2H95_02435	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H95_02445	COG1012	belongs to the aldehyde dehydrogenase family
C2H95_02450	COG1349	DNA-binding transcription factor activity
C2H95_02455	COG0667	Aldo Keto reductase
C2H95_02470	COG2814	Major facilitator Superfamily
C2H95_02475	COG0326	Molecular chaperone. Has ATPase activity
C2H95_02485	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_02490	COG1309	transcriptional regulator
C2H95_02495	COG1012	belongs to the aldehyde dehydrogenase family
C2H95_02505	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2H95_02515	COG1714	RDD family
C2H95_02520	COG2311	Membrane
C2H95_02525	COG1917	Cupin 2, conserved barrel domain protein
C2H95_02530	COG1309	transcriptional regulator
C2H95_02535	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_02540	COG1846	Transcriptional regulator
C2H95_02545	COG1380	Effector of murein hydrolase LrgA
C2H95_02550	COG1346	cytolysis
C2H95_02555	COG5039	Polysaccharide pyruvyl transferase
C2H95_02560	COG1929	Belongs to the glycerate kinase type-1 family
C2H95_02565	COG1802	Transcriptional regulator
C2H95_02570	COG1070	Carbohydrate kinase
C2H95_02575	COG2610	gluconate transmembrane transporter activity
C2H95_02580	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C2H95_02585	COG0450	alkyl hydroperoxide reductase
C2H95_02590	COG3634	alkyl hydroperoxide reductase activity
C2H95_02600	COG2723	6-phospho-beta-galactosidase activity
C2H95_02610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H95_02610	COG1263	PTS System
C2H95_02615	COG2188	Transcriptional regulator
C2H95_02630	COG1131	(ABC) transporter
C2H95_02635	COG1994	Peptidase M50
C2H95_02640	COG0535	radical SAM domain protein
C2H95_02650	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
C2H95_02670	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2H95_02680	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C2H95_02695	COG1063	alcohol dehydrogenase
C2H95_02715	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
C2H95_02720	COG0456	acetyltransferase
C2H95_02725	COG0457	Tetratricopeptide repeat
C2H95_02735	COG0010	Belongs to the arginase family
C2H95_02740	COG0833	amino acid
C2H95_02745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2H95_02750	COG3829	transcription factor binding
C2H95_02760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H95_02765	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C2H95_02770	COG4853	Protein conserved in bacteria
C2H95_02775	COG4863	YycH protein
C2H95_02780	COG5002	protein histidine kinase activity
C2H95_02785	COG0745	RESPONSE REGULATOR receiver
C2H95_02815	COG0346	lactoylglutathione lyase activity
C2H95_02820	COG0305	Participates in initiation and elongation during chromosome replication
C2H95_02835	COG3093	addiction module antidote protein HigA
C2H95_02840	COG2807	transmembrane transport
C2H95_02845	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2H95_02850	COG0359	binds to the 23S rRNA
C2H95_02855	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
C2H95_02860	COG4241	membrane
C2H95_02870	COG5577	PFAM Coat F domain
C2H95_02875	COG1733	regulation of RNA biosynthetic process
C2H95_02880	COG1227	inorganic diphosphatase activity
C2H95_02890	COG2271	Major facilitator Superfamily
C2H95_02895	COG4978	Transcriptional regulator
C2H95_02895	COG0789	Transcriptional regulator
C2H95_02905	COG4319	ketosteroid isomerase
C2H95_02915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H95_02920	COG1846	Transcriptional regulator
C2H95_02925	COG2153	protein acetylation
C2H95_02930	COG2364	Membrane
C2H95_02935	COG0456	acetyltransferase
C2H95_02940	COG2315	Protein conserved in bacteria
C2H95_02945	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2H95_02950	COG1331	Highly conserved protein containing a thioredoxin domain
C2H95_02965	COG0789	Transcriptional regulator
C2H95_02970	COG0697	spore germination
C2H95_02975	COG1331	Highly conserved protein containing a thioredoxin domain
C2H95_02980	COG1266	CAAX protease self-immunity
C2H95_02985	COG0477	Major facilitator Superfamily
C2H95_02985	COG2814	Major facilitator Superfamily
C2H95_02990	COG0110	maltose O-acetyltransferase activity
C2H95_02995	COG0346	lactoylglutathione lyase activity
C2H95_03000	COG1609	Transcriptional regulator
C2H95_03005	COG0708	Exodeoxyribonuclease III
C2H95_03010	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2H95_03015	COG0629	single-stranded DNA binding
C2H95_03020	COG0360	Binds together with S18 to 16S ribosomal RNA
C2H95_03025	COG0012	GTP binding
C2H95_03030	COG0243	molybdopterin cofactor binding
C2H95_03035	COG4481	Protein conserved in bacteria
C2H95_03040	COG3949	Membrane
C2H95_03050	COG1475	DNA binding
C2H95_03055	COG1192	Involved in chromosome partitioning
C2H95_03065	COG1475	DNA binding
C2H95_03070	COG0357	Ribosomal RNA small subunit methyltransferase G
C2H95_03075	COG0445	tRNA wobble uridine modification
C2H95_03080	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C2H95_03085	COG1847	R3H domain protein
C2H95_03090	COG0706	membrane insertase activity
C2H95_03095	COG0594	ribonuclease P activity
C2H95_03105	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C2H95_03110	COG0592	DNA-directed DNA polymerase activity
C2H95_03115	COG2501	S4 domain
C2H95_03120	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2H95_03130	COG0187	DNA topoisomerase II activity
C2H95_03135	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2H95_03170	COG0516	GMP reductase activity
C2H95_03170	COG0517	IMP dehydrogenase activity
C2H95_03175	COG1686	Belongs to the peptidase S11 family
C2H95_03180	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C2H95_03185	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C2H95_03190	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C2H95_03200	COG1428	Deoxynucleoside kinase
C2H95_03205	COG1428	Deoxynucleoside kinase
C2H95_03210	COG1388	LysM domain
C2H95_03210	COG3858	chitin binding
C2H95_03215	COG1335	isochorismatase
C2H95_03220	COG0590	tRNA wobble adenosine to inosine editing
C2H95_03230	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C2H95_03235	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C2H95_03240	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C2H95_03285	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
C2H95_03290	COG3853	Toxic anion resistance protein (TelA)
C2H95_03295	COG1982	Orn Lys Arg decarboxylase major
C2H95_03300	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C2H95_03305	COG3870	Protein conserved in bacteria
C2H95_03310	COG1728	Protein conserved in bacteria
C2H95_03315	COG0470	DNA polymerase III
C2H95_03320	COG1774	PSP1 C-terminal conserved region
C2H95_03325	COG4467	Involved in initiation control of chromosome replication
C2H95_03330	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C2H95_03335	COG2827	Endonuclease containing a URI domain
C2H95_03340	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2H95_03345	COG2002	toxin-antitoxin pair type II binding
C2H95_03350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H95_03350	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H95_03355	COG0084	hydrolase, TatD family'
C2H95_03360	COG3584	3D domain protein
C2H95_03360	COG3583	domain protein
C2H95_03365	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C2H95_03370	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2H95_03380	COG4466	Protein conserved in bacteria
C2H95_03390	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C2H95_03395	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2H95_03400	COG0251	oxidation-reduction process
C2H95_03405	COG2088	sporulation resulting in formation of a cellular spore
C2H95_03410	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2H95_03415	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2H95_03420	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C2H95_03425	COG0193	aminoacyl-tRNA hydrolase activity
C2H95_03435	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2H95_03440	COG2002	toxin-antitoxin pair type II binding
C2H95_03445	COG2244	polysaccharide biosynthetic process
C2H95_03450	COG3956	TIGRFAM MazG family protein
C2H95_03455	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C2H95_03470	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C2H95_03475	COG1098	S1 RNA binding domain
C2H95_03490	COG2208	phosphoserine phosphatase activity
C2H95_03495	COG2304	oxidoreductase activity
C2H95_03500	COG0515	serine threonine protein kinase
C2H95_03505	COG0037	tRNA processing
C2H95_03510	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C2H95_03515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2H95_03520	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C2H95_03525	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C2H95_03530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2H95_03535	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2H95_03540	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2H95_03545	COG0512	Glutamine amidotransferase of anthranilate synthase
C2H95_03550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2H95_03555	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2H95_03560	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2H95_03565	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2H95_03570	COG1396	sequence-specific DNA binding
C2H95_03575	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2H95_03580	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2H95_03660	COG4463	regulation of RNA biosynthetic process
C2H95_03665	COG3880	PFAM UvrB UvrC protein
C2H95_03670	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C2H95_03675	COG0542	response to heat
C2H95_03680	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2H95_03685	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C2H95_03690	COG4956	integral membrane protein (PIN domain superfamily)
C2H95_03695	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C2H95_03700	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C2H95_03705	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2H95_03715	COG1045	serine acetyltransferase
C2H95_03720	COG0215	cysteine-tRNA ligase activity
C2H95_03725	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C2H95_03730	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2H95_03735	COG3688	RNA-binding protein containing a PIN domain
C2H95_03740	COG1595	DNA-templated transcription, initiation
C2H95_03750	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2H95_03755	COG0250	Participates in transcription elongation, termination and antitermination
C2H95_03765	COG0081	regulation of translation
C2H95_03770	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C2H95_03780	COG2813	Specifically methylates the guanine in position
C2H95_03785	COG0085	RNA polymerase activity
C2H95_03790	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C2H95_03795	COG1358	cellular component organization or biogenesis
C2H95_03800	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C2H95_03805	COG0049	tRNA binding
C2H95_03810	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2H95_03815	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2H95_03820	COG0596	Alpha beta hydrolase
C2H95_03830	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C2H95_03835	COG0088	Forms part of the polypeptide exit tunnel
C2H95_03845	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C2H95_03865	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2H95_03875	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C2H95_03880	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C2H95_03890	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C2H95_03900	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C2H95_03905	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C2H95_03910	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C2H95_03915	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C2H95_03925	COG0200	Binds to the 23S rRNA
C2H95_03930	COG0201	protein transport
C2H95_03935	COG0563	adenylate kinase activity
C2H95_03940	COG0024	Methionine aminopeptidase
C2H95_03945	COG2163	COG2163 Ribosomal protein L14E L6E L27E
C2H95_03955	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2H95_03960	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C2H95_03965	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C2H95_03970	COG0202	RNA polymerase activity
C2H95_03975	COG0203	ribosomal protein L17
C2H95_03980	COG1122	ATPase activity
C2H95_03985	COG1122	ATPase activity
C2H95_03990	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C2H95_03995	COG0101	tRNA pseudouridine synthase activity
C2H95_04000	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2H95_04005	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C2H95_04010	COG2226	methyltransferase
C2H95_04020	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H95_04025	COG0489	protein tyrosine kinase activity
C2H95_04035	COG2194	sulfuric ester hydrolase activity
C2H95_04040	COG0726	polysaccharide deacetylase
C2H95_04140	COG0659	secondary active sulfate transmembrane transporter activity
C2H95_04145	COG0385	Bile acid
C2H95_04150	COG2819	hydrolase of the alpha beta superfamily
C2H95_04155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H95_04160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H95_04165	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H95_04170	COG2207	Transcriptional regulator
C2H95_04170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H95_04175	COG3876	Protein conserved in bacteria
C2H95_04180	COG1472	Belongs to the glycosyl hydrolase 3 family
C2H95_04185	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2H95_04190	COG1263	PTS System
C2H95_04190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H95_04195	COG1737	Transcriptional regulator
C2H95_04200	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C2H95_04205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H95_04210	COG1683	Conserved Protein
C2H95_04240	COG1595	DNA-templated transcription, initiation
C2H95_04245	COG5662	AntiSigma factor
C2H95_04250	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C2H95_04255	COG4856	YbbR-like protein
C2H95_04260	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2H95_04265	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2H95_04275	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2H95_04280	COG2169	Transcriptional regulator
C2H95_04285	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2H95_04290	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2H95_04295	COG3002	Belongs to the UPF0753 family
C2H95_04300	COG0288	reversible hydration of carbon dioxide
C2H95_04310	COG5609	conserved protein (DUF2294)
C2H95_04315	COG0640	Transcriptional regulator
C2H95_04320	COG2814	Major facilitator Superfamily
C2H95_04335	COG0596	Alpha beta hydrolase
C2H95_04340	COG0745	RESPONSE REGULATOR receiver
C2H95_04345	COG0642	Histidine kinase
C2H95_04355	COG0515	serine threonine protein kinase
C2H95_04370	COG1113	amino acid transport
C2H95_04385	COG2602	Beta-lactamase
C2H95_04390	COG2124	cytochrome p450
C2H95_04400	COG0531	amino acid
C2H95_04405	COG0584	glycerophosphoryl diester phosphodiesterase
C2H95_04410	COG2271	Major facilitator Superfamily
C2H95_04425	COG0456	acetyltransferase
C2H95_04425	COG1846	Transcriptional regulator
C2H95_04430	COG2271	Major facilitator Superfamily
C2H95_04440	COG3409	Peptidoglycan-binding domain 1 protein
C2H95_04445	COG0697	spore germination
C2H95_04450	COG2207	Transcriptional regulator
C2H95_04450	COG1917	Cupin 2, conserved barrel domain protein
C2H95_04455	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C2H95_04460	COG3591	Belongs to the peptidase S1B family
C2H95_04470	COG0596	Alpha beta hydrolase
C2H95_04475	COG1183	phosphatidylcholine synthase activity
C2H95_04480	COG0586	Pfam SNARE associated Golgi protein
C2H95_04485	COG0688	phosphatidylethanolamine metabolic process
C2H95_04500	COG1054	Belongs to the UPF0176 family
C2H95_04505	COG1301	dicarboxylic acid transport
C2H95_04510	COG2190	(PTS) system
C2H95_04510	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H95_04510	COG1263	PTS System
C2H95_04515	COG0363	glucosamine-6-phosphate deaminase activity
C2H95_04520	COG2188	Transcriptional regulator
C2H95_04530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2H95_04535	COG0833	amino acid
C2H95_04540	COG2040	homocysteine
C2H95_04550	COG1115	amino acid carrier protein
C2H95_04555	COG2066	Belongs to the glutaminase family
C2H95_04560	COG4191	Histidine kinase
C2H95_04565	COG0784	Response regulator, receiver
C2H95_04575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2H95_04580	COG1012	belongs to the aldehyde dehydrogenase family
C2H95_04585	COG2271	Major facilitator Superfamily
C2H95_04590	COG4948	Mandelate Racemase Muconate Lactonizing
C2H95_04595	COG2186	Transcriptional regulator
C2H95_04600	COG2721	sulfolactate sulfo-lyase activity
C2H95_04605	COG3173	Aminoglycoside phosphotransferase
C2H95_04615	COG0697	spore germination
C2H95_04620	COG0745	RESPONSE REGULATOR receiver
C2H95_04625	COG2205	protein histidine kinase activity
C2H95_04630	COG1131	(ABC) transporter
C2H95_04645	COG3773	Cell wall hydrolase
C2H95_04650	COG2304	oxidoreductase activity
C2H95_04660	COG3540	Alkaline phosphatase
C2H95_04665	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2H95_04670	COG0805	protein transport
C2H95_04675	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C2H95_04680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2H95_04685	COG0477	Major facilitator Superfamily
C2H95_04690	COG1309	transcriptional regulator
C2H95_04695	COG0252	asparaginase activity
C2H95_04700	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C2H95_04705	COG1714	RDD family
C2H95_04710	COG3012	SEC-C Motif Domain Protein
C2H95_04710	COG1405	negative regulation of cell septum assembly
C2H95_04715	COG3290	protein histidine kinase activity
C2H95_04720	COG3279	Response regulator of the LytR AlgR family
C2H95_04725	COG4555	ABC transporter
C2H95_04730	COG1668	transmembrane transport
C2H95_04735	COG0667	Aldo Keto reductase
C2H95_04745	COG1595	DNA-templated transcription, initiation
C2H95_04750	COG1595	DNA-templated transcription, initiation
C2H95_04755	COG1876	peptidase activity
C2H95_04760	COG0457	Tetratricopeptide repeat
C2H95_04765	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_04770	COG0366	Alpha amylase catalytic
C2H95_04775	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2H95_04780	COG1121	(ABC) transporter
C2H95_04785	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2H95_04790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H95_04795	COG2310	stress, protein
C2H95_04800	COG2310	stress, protein
C2H95_04805	COG2310	stress, protein
C2H95_04810	COG0861	Integral membrane protein TerC family
C2H95_04820	COG3853	Toxic anion resistance protein (TelA)
C2H95_04825	COG0477	Major facilitator Superfamily
C2H95_04835	COG2814	Major facilitator Superfamily
C2H95_04840	COG0640	Transcriptional regulator
C2H95_04845	COG4175	Glycine betaine
C2H95_04845	COG0517	IMP dehydrogenase activity
C2H95_04850	COG4176	ABC-type proline glycine betaine transport system permease component
C2H95_04855	COG2113	Glycine betaine
C2H95_04860	COG1473	amidohydrolase
C2H95_04865	COG1288	antiporter activity
C2H95_04875	COG0366	Alpha amylase catalytic
C2H95_04880	COG0039	L-malate dehydrogenase activity
C2H95_04885	COG1620	l-lactate permease
C2H95_04890	COG2814	Major facilitator Superfamily
C2H95_04895	COG1846	Transcriptional regulator
C2H95_04900	COG1280	lysine exporter protein (LysE YggA)
C2H95_04905	COG3403	YqcI/YcgG family
C2H95_04910	COG1113	amino acid transport
C2H95_04915	COG3665	Urea carboxylase-associated protein
C2H95_04920	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C2H95_04925	COG1660	Displays ATPase and GTPase activities
C2H95_04935	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2H95_04940	COG2226	methyltransferase
C2H95_04945	COG0583	DNA-binding transcription factor activity
C2H95_04950	COG3458	cephalosporin-C deacetylase activity
C2H95_04955	COG3541	Predicted nucleotidyltransferase
C2H95_04960	COG0506	proline dehydrogenase activity
C2H95_04965	COG1012	belongs to the aldehyde dehydrogenase family
C2H95_04970	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H95_04975	COG2508	Transcriptional regulator
C2H95_04980	COG3689	TIGRFAM TIGR03943 family protein
C2H95_04985	COG0701	Predicted permease
C2H95_04990	COG2267	carboxylic ester hydrolase activity
C2H95_04995	COG0492	ferredoxin-NADP+ reductase activity
C2H95_05000	COG1587	Uroporphyrinogen-III synthase
C2H95_05000	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2H95_05005	COG2146	nitrite reductase [NAD(P)H] activity
C2H95_05010	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2H95_05015	COG0243	molybdopterin cofactor binding
C2H95_05020	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2H95_05025	COG2223	nitrite transmembrane transporter activity
C2H95_05030	COG1469	GTP cyclohydrolase I activity
C2H95_05035	COG1376	ErfK ybiS ycfS ynhG family protein
C2H95_05040	COG0523	cobalamin synthesis protein
C2H95_05045	COG0765	amino acid transport
C2H95_05050	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H95_05055	COG1714	RDD family
C2H95_05065	COG1846	Transcriptional regulator
C2H95_05075	COG3842	ATPase activity
C2H95_05080	COG2723	6-phospho-beta-galactosidase activity
C2H95_05090	COG3209	COG3209 Rhs family protein
C2H95_05095	COG3290	protein histidine kinase activity
C2H95_05095	COG0840	transmembrane signaling receptor activity
C2H95_05100	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2H95_05105	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C2H95_05110	COG1733	regulation of RNA biosynthetic process
C2H95_05115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H95_05120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H95_05125	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H95_05130	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C2H95_05135	COG2814	Major facilitator Superfamily
C2H95_05145	COG0697	spore germination
C2H95_05150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H95_05160	COG2364	Membrane
C2H95_05165	COG1126	abc transporter atp-binding protein
C2H95_05170	COG0765	amino acid transport
C2H95_05175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H95_05180	COG0583	DNA-binding transcription factor activity
C2H95_05185	COG0163	prenyltransferase activity
C2H95_05190	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2H95_05205	COG0596	Alpha beta hydrolase
C2H95_05210	COG3104	oligopeptide transport
C2H95_05215	COG5434	Belongs to the glycosyl hydrolase 28 family
C2H95_05225	COG0697	spore germination
C2H95_05235	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2H95_05240	COG1136	(ABC) transporter
C2H95_05245	COG0577	efflux transmembrane transporter activity
C2H95_05250	COG0745	RESPONSE REGULATOR receiver
C2H95_05255	COG3850	Histidine kinase
C2H95_05255	COG5002	protein histidine kinase activity
C2H95_05260	COG0457	Tetratricopeptide repeat
C2H95_05280	COG0527	aspartate kinase activity
C2H95_05285	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H95_05290	COG4605	iron ion homeostasis
C2H95_05295	COG4604	ABC transporter, ATP-binding protein
C2H95_05300	COG4607	ABC-type enterochelin transport system periplasmic component
C2H95_05305	COG2814	Major facilitator Superfamily
C2H95_05310	COG1309	transcriptional regulator
C2H95_05315	COG0778	Nitroreductase
C2H95_05320	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C2H95_05325	COG0640	Transcriptional regulator
C2H95_05330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H95_05335	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2H95_05340	COG1012	belongs to the aldehyde dehydrogenase family
C2H95_05345	COG4975	Glucose uptake
C2H95_05350	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_05355	COG4549	nuclear export factor GLE1
C2H95_05360	COG2372	response to copper ion
C2H95_05360	COG1276	copper resistance
C2H95_05365	COG1349	DNA-binding transcription factor activity
C2H95_05375	COG2213	PTS system mannitol-specific
C2H95_05380	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H95_05385	COG0246	Mannitol dehydrogenase
C2H95_05390	COG0473	3-isopropylmalate dehydrogenase activity
C2H95_05395	COG0681	Belongs to the peptidase S26 family
C2H95_05400	COG0412	Dienelactone hydrolase
C2H95_05405	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2H95_05415	COG0561	phosphatase activity
C2H95_05420	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C2H95_05425	COG1914	H( )-stimulated, divalent metal cation uptake system
C2H95_05430	COG4336	lyase activity
C2H95_05435	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C2H95_05440	COG1984	allophanate hydrolase subunit 2
C2H95_05445	COG1414	Transcriptional regulator
C2H95_05450	COG2755	lipolytic protein G-D-S-L family
C2H95_05460	COG2329	Antibiotic biosynthesis monooxygenase
C2H95_05465	COG0768	penicillin binding
C2H95_05470	COG4989	oxidoreductase activity
C2H95_05475	COG3711	transcriptional antiterminator
C2H95_05480	COG0318	PFAM AMP-dependent synthetase and ligase
C2H95_05485	COG2226	methyltransferase
C2H95_05490	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_05495	COG1917	Cupin 2, conserved barrel domain protein
C2H95_05500	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H95_05505	COG3871	stress protein (general stress protein 26)
C2H95_05515	COG2814	Major facilitator Superfamily
C2H95_05520	COG1522	sequence-specific DNA binding
C2H95_05525	COG0551	DNA topoisomerase type I activity
C2H95_05525	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2H95_05530	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C2H95_05535	COG3706	GGDEF domain
C2H95_05540	COG5298	Protein conserved in bacteria
C2H95_05545	COG1215	transferase activity, transferring glycosyl groups
C2H95_05555	COG0531	amino acid
C2H95_05560	COG0494	nUDIX hydrolase
C2H95_05565	COG0028	Belongs to the TPP enzyme family
C2H95_05575	COG1914	H( )-stimulated, divalent metal cation uptake system
C2H95_05580	COG2261	transglycosylase associated protein
C2H95_05585	COG4876	unkown
C2H95_05590	COG2217	Heavy metal translocating P-type atpase
C2H95_05595	COG3729	General stress protein
C2H95_05600	COG0662	Cupin 2, conserved barrel domain protein
C2H95_05605	COG2329	Antibiotic biosynthesis monooxygenase
C2H95_05610	COG3546	catalase activity
C2H95_05615	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C2H95_05620	COG3290	protein histidine kinase activity
C2H95_05625	COG4565	transcriptional regulatory protein
C2H95_05630	COG1301	dicarboxylic acid transport
C2H95_05635	COG0628	permease
C2H95_05640	COG1131	(ABC) transporter
C2H95_05645	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2H95_05655	COG1960	acyl-CoA dehydrogenase activity
C2H95_05670	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2H95_05675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H95_05680	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2H95_05685	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2H95_05695	COG0513	Belongs to the DEAD box helicase family
C2H95_05700	COG3402	PFAM membrane-flanked domain
C2H95_05705	COG3428	Bacterial PH domain
C2H95_05710	COG0705	Rhomboid family
C2H95_05715	COG0736	holo-[acyl-carrier-protein] synthase activity
C2H95_05720	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2H95_05725	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2H95_05730	COG0864	Transcriptional regulator
C2H95_05735	COG2337	Toxic component of a toxin-antitoxin (TA) module
C2H95_05740	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H95_05745	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H95_05750	COG2172	sigma factor antagonist activity
C2H95_05755	COG2208	phosphoserine phosphatase activity
C2H95_05760	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H95_05765	COG2172	sigma factor antagonist activity
C2H95_05770	COG1191	sigma factor activity
C2H95_05775	COG2208	phosphoserine phosphatase activity
C2H95_05785	COG1673	EVE domain
C2H95_05790	COG1846	Transcriptional regulator
C2H95_05795	COG2183	response to ionizing radiation
C2H95_05805	COG3091	SprT-like family
C2H95_05855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2H95_05865	COG3764	Sortase (surface protein transpeptidase)
C2H95_05885	COG0693	protein deglycase activity
C2H95_05890	COG1278	Cold shock
C2H95_05895	COG1329	Transcriptional regulator
C2H95_05910	COG1917	Cupin 2, conserved barrel domain protein
C2H95_05910	COG2207	Transcriptional regulator
C2H95_05915	COG0697	spore germination
C2H95_05920	COG2207	Transcriptional regulator
C2H95_05920	COG3708	Transcriptional regulator
C2H95_05925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H95_05930	COG0477	Major facilitator Superfamily
C2H95_05940	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
C2H95_05955	COG0697	spore germination
C2H95_05960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H95_05965	COG2030	dehydratase
C2H95_05970	COG3545	Serine hydrolase
C2H95_05975	COG1733	regulation of RNA biosynthetic process
C2H95_05980	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H95_05985	COG0640	Transcriptional regulator
C2H95_05990	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2H95_06000	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H95_06005	COG1316	TRANSCRIPTIONal
C2H95_06025	COG0745	RESPONSE REGULATOR receiver
C2H95_06030	COG0697	spore germination
C2H95_06035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H95_06040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2H95_06045	COG0640	Transcriptional regulator
C2H95_06050	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2H95_06065	COG4585	Histidine kinase
C2H95_06070	COG2197	response regulator
C2H95_06075	COG2409	Drug exporters of the RND superfamily
C2H95_06080	COG1811	Na channel or pump
C2H95_06085	COG0789	Transcriptional regulator
C2H95_06085	COG4978	Transcriptional regulator
C2H95_06090	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2H95_06095	COG0778	Nitroreductase
C2H95_06100	COG0346	lactoylglutathione lyase activity
C2H95_06105	COG2259	Doxx family
C2H95_06110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H95_06130	COG2323	membrane
C2H95_06135	COG0071	Belongs to the small heat shock protein (HSP20) family
C2H95_06150	COG1309	transcriptional regulator
C2H95_06160	COG0456	acetyltransferase
C2H95_06165	COG0488	(ABC) transporter
C2H95_06170	COG1113	amino acid transport
C2H95_06175	COG2318	DinB family
C2H95_06180	COG1846	Transcriptional regulator
C2H95_06185	COG1033	growth of symbiont in host cell
C2H95_06185	COG2409	Drug exporters of the RND superfamily
C2H95_06190	COG0778	Nitroreductase
C2H95_06195	COG1846	Transcriptional regulator
C2H95_06200	COG2814	Major facilitator Superfamily
C2H95_06205	COG0730	response to heat
C2H95_06210	COG1802	Transcriptional regulator
C2H95_06215	COG1388	LysM domain
C2H95_06215	COG3858	chitin binding
C2H95_06220	COG1819	glycosyl
C2H95_06230	COG1785	Belongs to the alkaline phosphatase family
C2H95_06245	COG0454	-acetyltransferase
C2H95_06250	COG1078	dGTPase activity
C2H95_06255	COG1388	LysM domain
C2H95_06260	COG2814	Major facilitator Superfamily
C2H95_06265	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H95_06270	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2H95_06275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H95_06280	COG2723	6-phospho-beta-galactosidase activity
C2H95_06285	COG2188	Transcriptional regulator
C2H95_06290	COG1940	carbohydrate kinase activity
C2H95_06295	COG1482	cell wall glycoprotein biosynthetic process
C2H95_06300	COG4124	Belongs to the glycosyl hydrolase 26 family
C2H95_06345	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C2H95_06350	COG0802	atpase or kinase
C2H95_06355	COG1214	PFAM Peptidase M22, glycoprotease
C2H95_06360	COG0456	acetyltransferase
C2H95_06365	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C2H95_06370	COG0488	(ABC) transporter
C2H95_06375	COG0315	cyclic pyranopterin monophosphate synthase activity
C2H95_06380	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C2H95_06385	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2H95_06390	COG0805	protein transport
C2H95_06400	COG1266	CAAX protease self-immunity
C2H95_06410	COG0459	protein refolding
C2H95_06420	COG1073	alpha beta
C2H95_06425	COG0457	Tetratricopeptide repeat
C2H95_06430	COG1063	alcohol dehydrogenase
C2H95_06435	COG2211	Major facilitator Superfamily
C2H95_06440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H95_06445	COG1842	Phage shock protein A
C2H95_06450	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2H95_06455	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C2H95_06460	COG4260	virion core protein, lumpy skin disease virus
C2H95_06470	COG2814	Major facilitator Superfamily
C2H95_06475	COG1063	alcohol dehydrogenase
C2H95_06480	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2H95_06485	COG0823	Involved in the tonB-independent uptake of proteins
C2H95_06500	COG2267	carboxylic ester hydrolase activity
C2H95_06510	COG2132	Multicopper oxidase
C2H95_06515	COG1113	amino acid transport
C2H95_06525	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2H95_06530	COG0714	Associated with various cellular activities
C2H95_06535	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
C2H95_06540	COG1305	Transglutaminase-like
C2H95_06545	COG0519	Catalyzes the synthesis of GMP from XMP
C2H95_06545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2H95_06575	COG2252	PERMEase
C2H95_06580	COG3064	Membrane
C2H95_06590	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
C2H95_06600	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2H95_06605	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2H95_06610	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2H95_06615	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C2H95_06620	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2H95_06625	COG0047	phosphoribosylformylglycinamidine synthase activity
C2H95_06630	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2H95_06635	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2H95_06640	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C2H95_06645	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2H95_06650	COG0138	bifunctional purine biosynthesis protein purh
C2H95_06655	COG0151	Belongs to the GarS family
C2H95_06660	COG1522	sequence-specific DNA binding
C2H95_06665	COG0531	amino acid
C2H95_06675	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C2H95_06680	COG1470	cell adhesion involved in biofilm formation
C2H95_06685	COG4496	protein, YerC YecD
C2H95_06690	COG0069	glutamate synthase activity
C2H95_06695	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
C2H95_06700	COG0210	DNA helicase
C2H95_06705	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2H95_06710	COG4851	CamS sex pheromone cAM373 precursor
C2H95_06715	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H95_06720	COG1285	pathogenesis
C2H95_06725	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H95_06730	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2H95_06735	COG0154	amidase activity
C2H95_06740	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2H95_06745	COG1309	transcriptional regulator
C2H95_06750	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2H95_06755	COG1597	lipid kinase activity
C2H95_06760	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2H95_06780	COG0457	Tetratricopeptide repeat
C2H95_06795	COG5444	nuclease activity
C2H95_06805	COG3586	endonuclease activity
C2H95_06815	COG0457	Tetratricopeptide repeat
C2H95_06825	COG0217	transcriptional regulatory protein
C2H95_06835	COG1309	transcriptional regulator
C2H95_06840	COG3631	Ketosteroid isomerase-related protein
C2H95_06845	COG0702	epimerase
C2H95_06860	COG3546	catalase activity
C2H95_06865	COG0454	-acetyltransferase
C2H95_06875	COG5578	integral membrane protein
C2H95_06880	COG2972	Histidine kinase
C2H95_06885	COG2207	Transcriptional regulator
C2H95_06885	COG4753	response regulator
C2H95_06890	COG1653	transport
C2H95_06895	COG1175	transmembrane transport
C2H95_06900	COG0395	ABC-type sugar transport system, permease component
C2H95_06905	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2H95_06910	COG2207	Transcriptional regulator
C2H95_06915	COG2755	lipolytic protein G-D-S-L family
C2H95_06925	COG5578	integral membrane protein
C2H95_06930	COG3401	FG-GAP repeat protein
C2H95_06935	COG3401	FG-GAP repeat protein
C2H95_06940	COG2755	lipolytic protein G-D-S-L family
C2H95_06945	COG1874	Beta-galactosidase
C2H95_06955	COG1653	transport
C2H95_06960	COG4209	transmembrane transport
C2H95_06965	COG0395	ABC-type sugar transport system, permease component
C2H95_06970	COG1486	melibiose metabolic process
C2H95_06975	COG2323	membrane
C2H95_06980	COG2329	Antibiotic biosynthesis monooxygenase
C2H95_06985	COG0346	lactoylglutathione lyase activity
C2H95_07000	COG5583	Uncharacterized small protein (DUF2292)
C2H95_07005	COG0670	Belongs to the BI1 family
C2H95_07010	COG0697	spore germination
C2H95_07015	COG1846	Transcriptional regulator
C2H95_07020	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2H95_07035	COG2124	cytochrome p450
C2H95_07035	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2H95_07040	COG1368	sulfuric ester hydrolase activity
C2H95_07045	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2H95_07050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H95_07055	COG1442	glycosyl transferase family 8
C2H95_07060	COG1216	Glycosyl transferase, family 2
C2H95_07065	COG1442	glycosyl transferase family 8
C2H95_07070	COG2223	nitrite transmembrane transporter activity
C2H95_07075	COG1011	Hydrolase
C2H95_07080	COG0531	amino acid
C2H95_07085	COG1012	belongs to the aldehyde dehydrogenase family
C2H95_07090	COG0840	transmembrane signaling receptor activity
C2H95_07095	COG0488	(ABC) transporter
C2H95_07105	COG0789	Transcriptional regulator
C2H95_07110	COG2814	Major facilitator Superfamily
C2H95_07115	COG1404	Belongs to the peptidase S8 family
C2H95_07130	COG0488	(ABC) transporter
C2H95_07135	COG0513	Belongs to the DEAD box helicase family
C2H95_07140	COG0456	acetyltransferase
C2H95_07145	COG2130	NADP-dependent
C2H95_07150	COG1120	ATPase activity
C2H95_07155	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H95_07160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H95_07165	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C2H95_07185	COG3866	Pectate lyase
C2H95_07190	COG0471	metal ion transport
C2H95_07195	COG3290	protein histidine kinase activity
C2H95_07200	COG4565	transcriptional regulatory protein
C2H95_07205	COG3181	Tripartite tricarboxylate transporter family receptor
C2H95_07210	COG2851	Citrate transporter
C2H95_07215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H95_07220	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
C2H95_07225	COG1254	Belongs to the acylphosphatase family
C2H95_07230	COG2258	MOSC domain
C2H95_07250	COG0024	Methionine aminopeptidase
C2H95_07255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H95_07255	COG1263	PTS System
C2H95_07260	COG1368	sulfuric ester hydrolase activity
C2H95_07275	COG1115	amino acid carrier protein
C2H95_07280	COG0531	amino acid
C2H95_07295	COG0697	spore germination
C2H95_07300	COG1263	PTS System
C2H95_07300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H95_07305	COG0366	Alpha amylase catalytic
C2H95_07310	COG2188	Transcriptional regulator
C2H95_07315	COG0778	Nitroreductase
C2H95_07320	COG0737	Belongs to the 5'-nucleotidase family
C2H95_07325	COG0693	protein deglycase activity
C2H95_07330	COG2814	Major facilitator Superfamily
C2H95_07335	COG4840	Belongs to the UPF0435 family
C2H95_07340	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2H95_07345	COG4980	gas vesicle protein
C2H95_07350	COG1295	ribonuclease BN
C2H95_07355	COG0477	Major facilitator Superfamily
C2H95_07360	COG0387	Pfam Sodium calcium exchanger
C2H95_07370	COG0668	transmembrane transport
C2H95_07375	COG0535	radical SAM domain protein
C2H95_07385	COG0726	polysaccharide deacetylase
C2H95_07390	COG2084	Dehydrogenase
C2H95_07395	COG0598	Magnesium transport protein CorA
C2H95_07400	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2H95_07405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2H95_07415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2H95_07420	COG4637	Psort location Cytoplasmic, score
C2H95_07430	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2H95_07435	COG0022	dehydrogenase e1 component
C2H95_07440	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H95_07445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2H95_07450	COG3284	Transcriptional regulator
C2H95_07460	COG1742	UPF0060 membrane protein
C2H95_07485	COG4842	Belongs to the WXG100 family
C2H95_07490	COG1486	melibiose metabolic process
C2H95_07495	COG1737	Transcriptional regulator
C2H95_07500	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H95_07500	COG1263	PTS System
C2H95_07510	COG1132	(ABC) transporter
C2H95_07515	COG1132	(ABC) transporter
C2H95_07520	COG2259	Doxx family
C2H95_07525	COG2514	catechol 2,3-dioxygenase activity
C2H95_07530	COG4585	Histidine kinase
C2H95_07535	COG2197	response regulator
C2H95_07545	COG1131	(ABC) transporter
C2H95_07550	COG1511	domain protein
C2H95_07550	COG0842	Transport permease protein
C2H95_07555	COG0842	Transport permease protein
C2H95_07560	COG1695	Transcriptional regulator
C2H95_07565	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C2H95_07570	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
C2H95_07575	COG2318	DinB family
C2H95_07580	COG2814	Major facilitator Superfamily
C2H95_07585	COG1846	Transcriptional regulator
C2H95_07590	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C2H95_07590	COG0392	lysyltransferase activity
C2H95_07595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H95_07600	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H95_07605	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H95_07610	COG0384	phenazine biosynthesis protein PhzF
C2H95_07615	COG0778	Nitroreductase
C2H95_07630	COG1090	epimerase
C2H95_07635	COG2137	regulation of response to DNA damage stimulus
C2H95_07645	COG2814	Major facilitator Superfamily
C2H95_07660	COG3103	Sh3 type 3 domain protein
C2H95_07665	COG5658	integral membrane protein
C2H95_07670	COG0596	Alpha beta hydrolase
C2H95_07675	COG0463	Glycosyl transferase, family 2
C2H95_07680	COG4485	Bacterial membrane protein, YfhO
C2H95_07685	COG1988	membrane-bound metal-dependent
C2H95_07690	COG1194	a g-specific adenine glycosylase
C2H95_07700	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_07715	COG3557	Belongs to the UPF0374 family
C2H95_07720	COG1132	(ABC) transporter
C2H95_07725	COG4129	membrane
C2H95_07730	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2H95_07735	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2H95_07740	COG0735	belongs to the Fur family
C2H95_07850	COG4326	sporulation control protein
C2H95_07860	COG5577	PFAM Coat F domain
C2H95_07865	COG3340	Belongs to the peptidase S51 family
C2H95_07870	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C2H95_07885	COG0753	catalase activity
C2H95_07890	COG1116	anion transmembrane transporter activity
C2H95_07895	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2H95_07900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2H95_07905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H95_07915	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C2H95_07925	COG1476	TRANSCRIPTIONal
C2H95_07935	COG3382	B3 4 domain protein
C2H95_07940	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2H95_07950	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2H95_07955	COG0789	Transcriptional regulator
C2H95_07960	COG1664	Polymer-forming cytoskeletal
C2H95_07965	COG1664	Polymer-forming cytoskeletal
C2H95_07970	COG2766	serine protein kinase
C2H95_07975	COG2718	Belongs to the UPF0229 family
C2H95_07980	COG1846	Transcriptional regulator
C2H95_07985	COG1566	PFAM secretion protein HlyD family protein
C2H95_07990	COG2814	Major facilitator Superfamily
C2H95_07995	COG0655	NAD(P)H dehydrogenase (quinone) activity
C2H95_08015	COG1725	Transcriptional regulator
C2H95_08020	COG1131	(ABC) transporter
C2H95_08025	COG1131	(ABC) transporter
C2H95_08030	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2H95_08035	COG1278	Cold shock
C2H95_08045	COG1464	Belongs to the NlpA lipoprotein family
C2H95_08050	COG3706	GGDEF domain
C2H95_08055	COG1823	symporter activity
C2H95_08085	COG5577	PFAM Coat F domain
C2H95_08090	COG4085	toxin activity
C2H95_08090	COG1525	nuclease
C2H95_08090	COG0737	Belongs to the 5'-nucleotidase family
C2H95_08095	COG3764	Sortase (surface protein transpeptidase)
C2H95_08100	COG0564	pseudouridine synthase activity
C2H95_08110	COG0517	IMP dehydrogenase activity
C2H95_08115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2H95_08120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2H95_08120	COG3153	acetyltransferase
C2H95_08130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2H95_08135	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
C2H95_08140	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2H95_08145	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2H95_08150	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2H95_08155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2H95_08160	COG2203	Gaf domain
C2H95_08160	COG4585	Histidine kinase
C2H95_08165	COG2197	response regulator
C2H95_08170	COG0431	NADPH-dependent FMN reductase
C2H95_08185	COG0791	NLP P60 protein
C2H95_08185	COG1388	LysM domain
C2H95_08190	COG1959	2 iron, 2 sulfur cluster binding
C2H95_08195	COG0668	transmembrane transport
C2H95_08200	COG2719	SpoVR family
C2H95_08205	COG1785	Belongs to the alkaline phosphatase family
C2H95_08210	COG1388	LysM domain
C2H95_08210	COG0791	NLP P60 protein
C2H95_08215	COG0583	DNA-binding transcription factor activity
C2H95_08220	COG0372	Belongs to the citrate synthase family
C2H95_08225	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_08230	COG0531	amino acid
C2H95_08235	COG0733	neurotransmitter:sodium symporter activity
C2H95_08240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H95_08245	COG0456	acetyltransferase
C2H95_08260	COG1595	DNA-templated transcription, initiation
C2H95_08265	COG0667	Aldo Keto reductase
C2H95_08270	COG0204	Acyl-transferase
C2H95_08275	COG1253	flavin adenine dinucleotide binding
C2H95_08280	COG0789	Transcriptional regulator
C2H95_08285	COG0436	Aminotransferase
C2H95_08290	COG1253	flavin adenine dinucleotide binding
C2H95_08295	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2H95_08300	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2H95_08305	COG0584	glycerophosphoryl diester phosphodiesterase
C2H95_08315	COG0668	transmembrane transport
C2H95_08320	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2H95_08325	COG0726	polysaccharide deacetylase
C2H95_08330	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2H95_08335	COG1757	Na H antiporter
C2H95_08340	COG0589	response to stress
C2H95_08350	COG1132	(ABC) transporter
C2H95_08355	COG1132	(ABC) transporter
C2H95_08360	COG0702	epimerase
C2H95_08380	COG0189	ligase activity
C2H95_08385	COG0189	ligase activity
C2H95_08390	COG4399	Belongs to the UPF0754 family
C2H95_08395	COG3679	Belongs to the UPF0342 family
C2H95_08400	COG4335	DNA alkylation repair
C2H95_08405	COG0561	phosphatase activity
C2H95_08410	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2H95_08415	COG0475	glutathione-regulated potassium exporter activity
C2H95_08420	COG0490	domain, Protein
C2H95_08430	COG1024	Enoyl-CoA hydratase
C2H95_08440	COG4152	abc transporter atp-binding protein
C2H95_08445	COG1668	transmembrane transport
C2H95_08450	COG0420	3'-5' exonuclease activity
C2H95_08455	COG4717	serine-type aminopeptidase activity
C2H95_08460	COG3481	metal-dependent phosphohydrolase, HD sub domain
C2H95_08470	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2H95_08500	COG1846	Transcriptional regulator
C2H95_08505	COG4980	gas vesicle protein
C2H95_08520	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C2H95_08525	COG0537	adenosine 5'-monophosphoramidase activity
C2H95_08530	COG1131	(ABC) transporter
C2H95_08535	COG4473	ABC transporter
C2H95_08545	COG1473	amidohydrolase
C2H95_08550	COG3069	C4-dicarboxylate transmembrane transporter activity
C2H95_08560	COG2329	Antibiotic biosynthesis monooxygenase
C2H95_08565	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2H95_08570	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C2H95_08575	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C2H95_08580	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C2H95_08585	COG1309	transcriptional regulator
C2H95_08590	COG1511	domain protein
C2H95_08595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2H95_08600	COG4377	Putative membrane peptidase family (DUF2324)
C2H95_08610	COG1363	Peptidase, m42
C2H95_08615	COG4405	Protein conserved in bacteria
C2H95_08620	COG1301	dicarboxylic acid transport
C2H95_08630	COG1234	tRNA 3'-trailer cleavage
C2H95_08635	COG0095	Lipoate-protein ligase
C2H95_08640	COG0702	epimerase
C2H95_08645	COG0318	PFAM AMP-dependent synthetase and ligase
C2H95_08655	COG0501	Belongs to the peptidase M48B family
C2H95_08665	COG0456	acetyltransferase
C2H95_08670	COG0604	alcohol dehydrogenase
C2H95_08675	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C2H95_08680	COG0406	alpha-ribazole phosphatase activity
C2H95_08685	COG0183	Belongs to the thiolase family
C2H95_08690	COG0318	PFAM AMP-dependent synthetase and ligase
C2H95_08695	COG1268	BioY protein
C2H95_08700	COG0840	transmembrane signaling receptor activity
C2H95_08705	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2H95_08705	COG0723	plastoquinol--plastocyanin reductase activity
C2H95_08710	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_08720	COG4903	ComK protein
C2H95_08725	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_08735	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H95_08750	COG0398	Pfam SNARE associated Golgi protein
C2H95_08755	COG0681	Belongs to the peptidase S26 family
C2H95_08760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2H95_08765	COG1846	Transcriptional regulator
C2H95_08770	COG0738	Major facilitator superfamily
C2H95_08775	COG0673	inositol 2-dehydrogenase activity
C2H95_08780	COG0561	phosphatase activity
C2H95_08785	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2H95_08790	COG1609	Transcriptional regulator
C2H95_08795	COG3180	Ammonia monooxygenase
C2H95_08800	COG0477	Major facilitator Superfamily
C2H95_08800	COG2814	Major facilitator Superfamily
C2H95_08805	COG4533	DNA binding
C2H95_08815	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
C2H95_08820	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C2H95_08825	COG1074	ATP-dependent DNA helicase activity
C2H95_08830	COG0420	3'-5' exonuclease activity
C2H95_08835	COG0419	ATPase involved in DNA repair
C2H95_08840	COG1403	HNH endonuclease
C2H95_08880	COG5337	Spore coat protein CotH
C2H95_08885	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2H95_08895	COG1404	Belongs to the peptidase S8 family
C2H95_08905	COG0367	asparagine synthase
C2H95_08910	COG2318	DinB family
C2H95_08915	COG1562	ergosterol biosynthetic process
C2H95_08920	COG0534	Mate efflux family protein
C2H95_08925	COG1917	Cupin 2, conserved barrel domain protein
C2H95_08925	COG2207	Transcriptional regulator
C2H95_08930	COG1609	Transcriptional regulator
C2H95_08935	COG0673	inositol 2-dehydrogenase activity
C2H95_08940	COG2318	DinB family
C2H95_08945	COG1279	arginine transmembrane transporter activity
C2H95_08950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H95_08955	COG1357	PFAM Pentapeptide repeats (8 copies)
C2H95_08960	COG2267	carboxylic ester hydrolase activity
C2H95_08965	COG0529	Catalyzes the synthesis of activated sulfate
C2H95_08970	COG2046	Belongs to the sulfate adenylyltransferase family
C2H95_08975	COG0175	sulfate reduction
C2H95_08980	COG2045	Belongs to the ComB family
C2H95_08985	COG1809	phosphosulfolactate synthase activity
C2H95_08990	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H95_08995	COG4948	Mandelate Racemase Muconate Lactonizing
C2H95_09000	COG2814	Major facilitator Superfamily
C2H95_09005	COG0454	-acetyltransferase
C2H95_09010	COG2153	protein acetylation
C2H95_09015	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C2H95_09015	COG0646	methionine synthase
C2H95_09020	COG1666	GTP binding
C2H95_09025	COG2996	Protein conserved in bacteria
C2H95_09045	COG1695	Transcriptional regulator
C2H95_09060	COG3227	Zinc metalloprotease (Elastase)
C2H95_09065	COG1307	EDD domain protein, DegV family
C2H95_09070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H95_09085	COG0561	phosphatase activity
C2H95_09090	COG1073	alpha beta
C2H95_09095	COG2151	metal-sulfur cluster biosynthetic enzyme
C2H95_09110	COG2271	Major facilitator Superfamily
C2H95_09115	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2H95_09120	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C2H95_09130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2H95_09135	COG0505	Belongs to the CarA family
C2H95_09140	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2H95_09145	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2H95_09160	COG2267	carboxylic ester hydrolase activity
C2H95_09170	COG1744	ABC transporter substrate-binding protein PnrA-like
C2H95_09185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2H95_09190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2H95_09195	COG5504	Zn-dependent protease
C2H95_09200	COG0444	Belongs to the ABC transporter superfamily
C2H95_09205	COG4608	Belongs to the ABC transporter superfamily
C2H95_09215	COG0601	transmembrane transport
C2H95_09220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2H95_09230	COG0180	Tryptophanyl-tRNA synthetase
C2H95_09235	COG4166	transmembrane transport
C2H95_09240	COG0601	transmembrane transport
C2H95_09245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2H95_09250	COG0444	Belongs to the ABC transporter superfamily
C2H95_09255	COG4608	Belongs to the ABC transporter superfamily
C2H95_09260	COG2814	Major facilitator Superfamily
C2H95_09265	COG0456	acetyltransferase
C2H95_09270	COG1393	Belongs to the ArsC family
C2H95_09275	COG0861	Integral membrane protein TerC family
C2H95_09280	COG4862	establishment of competence for transformation
C2H95_09285	COG4469	Competence protein
C2H95_09290	COG1164	Oligoendopeptidase f
C2H95_09305	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C2H95_09310	COG2346	COG2346, Truncated hemoglobins
C2H95_09315	COG0741	lytic transglycosylase activity
C2H95_09320	COG4116	CYTH
C2H95_09330	COG2357	RelA SpoT domain protein
C2H95_09335	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2H95_09340	COG0564	pseudouridine synthase activity
C2H95_09345	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2H95_09350	COG0475	glutathione-regulated potassium exporter activity
C2H95_09350	COG0569	domain protein
C2H95_09355	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2H95_09360	COG0352	thiamine-phosphate diphosphorylase activity
C2H95_09365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2H95_09370	COG2104	thiamine diphosphate biosynthetic process
C2H95_09375	COG2022	thiamine diphosphate biosynthetic process
C2H95_09380	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2H95_09385	COG0351	phosphomethylpyrimidine kinase
C2H95_09390	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2H95_09445	COG0210	DNA helicase
C2H95_09455	COG2153	protein acetylation
C2H95_09460	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2H95_09465	COG2382	esterase
C2H95_09470	COG0626	cystathionine gamma-synthase activity
C2H95_09475	COG0626	cystathionine gamma-synthase activity
C2H95_09480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H95_09485	COG5505	Protein of unknown function (DUF819)
C2H95_09515	COG5444	nuclease activity
C2H95_09545	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C2H95_09555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H95_09555	COG3711	transcriptional antiterminator
C2H95_09560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H95_09560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H95_09560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H95_09565	COG1482	cell wall glycoprotein biosynthetic process
C2H95_09575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H95_09585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2H95_09615	COG0726	polysaccharide deacetylase
C2H95_09635	COG2205	protein histidine kinase activity
C2H95_09645	COG3383	formate dehydrogenase (NAD+) activity
C2H95_09650	COG2427	Protein of unknown function (DUF1641)
C2H95_09660	COG1051	belongs to the nudix hydrolase family
C2H95_09670	COG2124	cytochrome p450
C2H95_09675	COG1819	glycosyl
C2H95_09685	COG1587	Uroporphyrinogen-III synthase
C2H95_09690	COG0390	transport system, permease component
C2H95_09695	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2H95_09700	COG0697	spore germination
C2H95_09705	COG4297	protein containing double-stranded beta helix domain
C2H95_09715	COG1252	NADH dehydrogenase
C2H95_09720	COG1904	glucuronate isomerase
C2H95_09725	COG2211	Major facilitator Superfamily
C2H95_09730	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C2H95_09735	COG1063	alcohol dehydrogenase
C2H95_09740	COG1312	Catalyzes the dehydration of D-mannonate
C2H95_09745	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_09750	COG2271	Major facilitator Superfamily
C2H95_09755	COG1609	Transcriptional regulator
C2H95_09760	COG0246	Mannitol dehydrogenase
C2H95_09765	COG2721	sulfolactate sulfo-lyase activity
C2H95_09770	COG0730	response to heat
C2H95_09775	COG2318	DinB family
C2H95_09780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2H95_09785	COG0457	Tetratricopeptide repeat
C2H95_09795	COG2350	Protein conserved in bacteria
C2H95_09800	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2H95_09800	COG3409	Peptidoglycan-binding domain 1 protein
C2H95_09800	COG1388	LysM domain
C2H95_09810	COG4195	phage-related replication protein
C2H95_09815	COG3546	catalase activity
C2H95_09820	COG2856	Zn peptidase
C2H95_09825	COG1396	sequence-specific DNA binding
C2H95_09835	COG1522	sequence-specific DNA binding
C2H95_09840	COG1484	DNA-dependent DNA replication
C2H95_09860	COG1595	DNA-templated transcription, initiation
C2H95_09865	COG5484	DNA packaging
C2H95_09865	COG3728	DNA packaging
C2H95_09875	COG5518	Phage portal protein
C2H95_09880	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C2H95_09885	COG4653	Phage capsid family
C2H95_09935	COG3953	SLT domain
C2H95_09935	COG5412	phage tail tape measure protein
C2H95_09935	COG3953	SLT domain
C2H95_09935	COG5412	phage tail tape measure protein
C2H95_09940	COG1652	LysM domain
C2H95_09945	COG4193	domain, Protein
C2H95_09955	COG3628	GPW Gp25 family protein
C2H95_09960	COG3299	homolog of phage Mu protein gp47
C2H95_09965	COG3778	Protein conserved in bacteria
C2H95_10005	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2H95_10005	COG3409	Peptidoglycan-binding domain 1 protein
C2H95_10020	COG0306	phosphate transporter
C2H95_10025	COG1392	Phosphate transport regulator
C2H95_10030	COG0531	amino acid
C2H95_10035	COG0346	lactoylglutathione lyase activity
C2H95_10040	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2H95_10045	COG0463	Glycosyl transferase, family 2
C2H95_10060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H95_10065	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2H95_10070	COG2362	D-Aminopeptidase
C2H95_10075	COG0601	transmembrane transport
C2H95_10080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2H95_10085	COG0444	Belongs to the ABC transporter superfamily
C2H95_10090	COG4166	transmembrane transport
C2H95_10095	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2H95_10100	COG4948	Mandelate Racemase Muconate Lactonizing
C2H95_10105	COG0791	NLP P60 protein
C2H95_10110	COG4608	Belongs to the ABC transporter superfamily
C2H95_10115	COG2706	6-phosphogluconolactonase activity
C2H95_10120	COG1834	amidinotransferase
C2H95_10125	COG1607	acyl-coa hydrolase
C2H95_10130	COG1017	nitric oxide dioxygenase activity
C2H95_10130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2H95_10140	COG2323	membrane
C2H95_10145	COG2318	DinB family
C2H95_10150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H95_10155	COG2076	Multidrug Resistance protein
C2H95_10160	COG2076	Multidrug Resistance protein
C2H95_10165	COG0788	formyltetrahydrofolate deformylase activity
C2H95_10170	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C2H95_10175	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C2H95_10180	COG1764	response to oxidative stress
C2H95_10185	COG1846	Transcriptional regulator
C2H95_10190	COG1764	response to oxidative stress
C2H95_10195	COG0590	tRNA wobble adenosine to inosine editing
C2H95_10200	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2H95_10205	COG1404	Belongs to the peptidase S8 family
C2H95_10210	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H95_10215	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C2H95_10220	COG1122	ATPase activity
C2H95_10225	COG4721	ABC-type cobalt transport system, permease component
C2H95_10235	COG0745	RESPONSE REGULATOR receiver
C2H95_10240	COG5002	protein histidine kinase activity
C2H95_10240	COG3850	Histidine kinase
C2H95_10245	COG3212	peptidase
C2H95_10250	COG3212	peptidase
C2H95_10265	COG2239	Acts as a magnesium transporter
C2H95_10270	COG0789	Transcriptional regulator
C2H95_10285	COG1846	Transcriptional regulator
C2H95_10290	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2H95_10295	COG0726	polysaccharide deacetylase
C2H95_10300	COG1408	metallophosphoesterase
C2H95_10310	COG0463	Glycosyl transferase, family 2
C2H95_10315	COG1793	dna ligase
C2H95_10315	COG3285	dna ligase
C2H95_10320	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C2H95_10325	COG3300	MHYT domain
C2H95_10325	COG5001	Diguanylate cyclase
C2H95_10330	COG0586	Pfam SNARE associated Golgi protein
C2H95_10335	COG0861	Integral membrane protein TerC family
C2H95_10340	COG1191	sigma factor activity
C2H95_10360	COG0501	Belongs to the peptidase M48B family
C2H95_10365	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2H95_10380	COG3594	Acyltransferase
C2H95_10385	COG5002	protein histidine kinase activity
C2H95_10390	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2H95_10395	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C2H95_10400	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
C2H95_10405	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2H95_10410	COG0436	Aminotransferase
C2H95_10415	COG1850	ribulose-bisphosphate carboxylase activity
C2H95_10420	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
C2H95_10425	COG0235	Class ii aldolase
C2H95_10430	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C2H95_10435	COG3339	Conserved Protein
C2H95_10450	COG3852	Histidine kinase
C2H95_10455	COG1846	Transcriptional regulator
C2H95_10460	COG1360	Flagellar Motor Protein
C2H95_10465	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2H95_10470	COG0542	response to heat
C2H95_10475	COG3949	Membrane
C2H95_10480	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C2H95_10485	COG0720	synthase
C2H95_10490	COG0602	queuosine metabolic process
C2H95_10495	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2H95_10500	COG1733	regulation of RNA biosynthetic process
C2H95_10505	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_10510	COG1388	LysM domain
C2H95_10510	COG4641	Protein conserved in bacteria
C2H95_10515	COG1388	LysM domain
C2H95_10520	COG3858	chitin binding
C2H95_10530	COG4873	Protein conserved in bacteria
C2H95_10540	COG3773	Cell wall hydrolase
C2H95_10545	COG2244	polysaccharide biosynthetic process
C2H95_10550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H95_10555	COG2217	Heavy metal translocating P-type atpase
C2H95_10565	COG0006	proline dipeptidase activity
C2H95_10570	COG1609	Transcriptional regulator
C2H95_10575	COG3711	transcriptional antiterminator
C2H95_10580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H95_10580	COG1263	PTS System
C2H95_10580	COG2190	(PTS) system
C2H95_10585	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H95_10590	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2H95_10600	COG1533	DNA photolyase activity
C2H95_10610	COG0840	transmembrane signaling receptor activity
C2H95_10615	COG2084	Dehydrogenase
C2H95_10620	COG4257	antibiotic catabolic process
C2H95_10625	COG2340	Cysteine-rich secretory protein family
C2H95_10630	COG0768	penicillin binding
C2H95_10635	COG4191	Histidine kinase
C2H95_10640	COG0436	Aminotransferase
C2H95_10650	COG0784	Response regulator, receiver
C2H95_10650	COG0835	chemotaxis
C2H95_10660	COG2814	Major facilitator Superfamily
C2H95_10665	COG1376	ErfK ybiS ycfS ynhG family protein
C2H95_10670	COG1408	metallophosphoesterase
C2H95_10675	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_10680	COG2200	EAL domain
C2H95_10685	COG4703	Protein of unknown function (DUF1797)
C2H95_10690	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
C2H95_10700	COG0517	IMP dehydrogenase activity
C2H95_10705	COG0583	DNA-binding transcription factor activity
C2H95_10710	COG0716	FMN binding
C2H95_10720	COG0716	FMN binding
C2H95_10725	COG2171	N-acyltransferase activity
C2H95_10730	COG1473	amidohydrolase
C2H95_10740	COG0668	transmembrane transport
C2H95_10745	COG0450	alkyl hydroperoxide reductase
C2H95_10750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H95_10765	COG0746	molybdenum cofactor guanylyltransferase activity
C2H95_10770	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2H95_10775	COG0303	'Molybdopterin
C2H95_10780	COG1763	Mo-molybdopterin cofactor biosynthetic process
C2H95_10785	COG0314	molybdopterin synthase activity
C2H95_10790	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C2H95_10795	COG1132	(ABC) transporter
C2H95_10800	COG1132	(ABC) transporter
C2H95_10810	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2H95_10815	COG1136	(ABC) transporter
C2H95_10820	COG0577	efflux transmembrane transporter activity
C2H95_10825	COG1349	DNA-binding transcription factor activity
C2H95_10830	COG1105	Belongs to the carbohydrate kinase PfkB family
C2H95_10835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H95_10835	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H95_10835	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H95_10840	COG0681	Belongs to the peptidase S26 family
C2H95_10850	COG0488	(ABC) transporter
C2H95_10855	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2H95_10860	COG2309	aminopeptidase activity
C2H95_10870	COG1077	Cell shape determining protein MreB Mrl
C2H95_10875	COG2002	toxin-antitoxin pair type II binding
C2H95_10880	COG3852	Histidine kinase
C2H95_10885	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C2H95_10885	COG2105	PFAM AIG2 family protein
C2H95_10890	COG0569	domain protein
C2H95_10895	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C2H95_10900	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2H95_10905	COG5503	Protein of unknown function (DUF1447)
C2H95_10910	COG0561	phosphatase activity
C2H95_10915	COG0242	peptide deformylase activity
C2H95_10925	COG0497	DNA recombination
C2H95_10930	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2H95_10935	COG0022	dehydrogenase e1 component
C2H95_10940	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H95_10945	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2H95_10950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H95_10960	COG1982	Orn Lys Arg decarboxylase major
C2H95_10965	COG4476	Belongs to the UPF0223 family
C2H95_10970	COG4493	Belongs to the UPF0637 family
C2H95_10980	COG0483	inositol monophosphate 1-phosphatase activity
C2H95_10990	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C2H95_11010	COG1595	DNA-templated transcription, initiation
C2H95_11030	COG1217	gtp-binding protein TYPA
C2H95_11040	COG4896	Protein conserved in bacteria
C2H95_11050	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C2H95_11055	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2H95_11060	COG2066	Belongs to the glutaminase family
C2H95_11065	COG4838	Belongs to the UPF0358 family
C2H95_11070	COG0772	Belongs to the SEDS family
C2H95_11075	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C2H95_11080	COG1612	heme a metabolic process
C2H95_11085	COG0109	protoheme IX farnesyltransferase activity
C2H95_11090	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2H95_11090	COG2010	Cytochrome c
C2H95_11095	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2H95_11100	COG1845	cytochrome c oxidase, subunit III
C2H95_11105	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2H95_11110	COG3336	cytochrome c oxidase
C2H95_11120	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C2H95_11125	COG2340	Cysteine-rich secretory protein family
C2H95_11140	COG3679	Belongs to the UPF0342 family
C2H95_11145	COG4471	UPF0298 protein
C2H95_11150	COG0742	ribosomal rna small subunit methyltransferase
C2H95_11155	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C2H95_11160	COG3314	Sporulation integral membrane protein YlbJ
C2H95_11165	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2H95_11170	COG3480	Lon protease (S16) C-terminal proteolytic domain
C2H95_11175	COG1323	Belongs to the UPF0348 family
C2H95_11185	COG1399	metal-binding, possibly nucleic acid-binding protein
C2H95_11200	COG0454	-acetyltransferase
C2H95_11205	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2H95_11210	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
C2H95_11215	COG2001	Belongs to the MraZ family
C2H95_11220	COG0275	rRNA processing
C2H95_11225	COG4839	cell division protein FtsL
C2H95_11230	COG0768	penicillin binding
C2H95_11235	COG0768	penicillin binding
C2H95_11240	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2H95_11245	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2H95_11250	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2H95_11255	COG0772	Belongs to the SEDS family
C2H95_11260	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2H95_11265	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C2H95_11270	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C2H95_11275	COG3879	Bacterial protein of unknown function (DUF881)
C2H95_11280	COG3879	Bacterial protein of unknown function (DUF881)
C2H95_11285	COG3856	small basic protein
C2H95_11290	COG0849	cell division
C2H95_11295	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2H95_11300	COG4412	M6 family metalloprotease domain protein
C2H95_11300	COG1404	Belongs to the peptidase S8 family
C2H95_11310	COG1191	sigma factor activity
C2H95_11315	COG1191	sigma factor activity
C2H95_11320	COG1119	ATPase activity
C2H95_11325	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2H95_11330	COG1873	PFAM PRC-barrel domain
C2H95_11335	COG1496	oxidoreductase activity
C2H95_11340	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2H95_11345	COG1799	cell septum assembly
C2H95_11350	COG0762	integral membrane protein
C2H95_11355	COG2302	S4 RNA-binding domain
C2H95_11360	COG3599	regulation of cell shape
C2H95_11365	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2H95_11370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2H95_11375	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C2H95_11380	COG0564	pseudouridine synthase activity
C2H95_11385	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C2H95_11390	COG2233	PERMEase
C2H95_11395	COG0540	Belongs to the ATCase OTCase family
C2H95_11400	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2H95_11405	COG0505	Belongs to the CarA family
C2H95_11410	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2H95_11415	COG0543	2 iron, 2 sulfur cluster binding
C2H95_11420	COG0167	dihydroorotate dehydrogenase activity
C2H95_11425	COG0284	orotidine-5'-phosphate decarboxylase activity
C2H95_11430	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C2H95_11435	COG0175	sulfate reduction
C2H95_11440	COG0306	phosphate transporter
C2H95_11445	COG2046	Belongs to the sulfate adenylyltransferase family
C2H95_11450	COG0529	Catalyzes the synthesis of activated sulfate
C2H95_11455	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2H95_11460	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
C2H95_11465	COG1648	precorrin-2 dehydrogenase activity
C2H95_11470	COG1293	RNA-binding protein homologous to eukaryotic snRNP
C2H95_11475	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C2H95_11480	COG1561	YicC-like family, N-terminal region
C2H95_11490	COG0194	GDP metabolic process
C2H95_11495	COG1758	RNA polymerase activity
C2H95_11500	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2H95_11505	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2H95_11510	COG0242	peptide deformylase activity
C2H95_11515	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2H95_11520	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2H95_11520	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2H95_11525	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C2H95_11530	COG0631	protein serine/threonine phosphatase activity
C2H95_11535	COG2815	serine threonine protein kinase
C2H95_11535	COG0515	serine threonine protein kinase
C2H95_11540	COG1162	GTPase activity
C2H95_11545	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2H95_11550	COG1564	THIamine pyrophosphokinase
C2H95_11560	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C2H95_11565	COG1302	Protein conserved in bacteria
C2H95_11570	COG1461	Dihydroxyacetone kinase
C2H95_11575	COG1760	l-serine dehydratase
C2H95_11580	COG1760	l-serine dehydratase
C2H95_11585	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2H95_11590	COG2050	protein possibly involved in aromatic compounds catabolism
C2H95_11590	COG1349	DNA-binding transcription factor activity
C2H95_11595	COG0416	fatty acid biosynthetic process
C2H95_11600	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2H95_11605	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_11615	COG0571	ribonuclease III activity
C2H95_11620	COG1196	nuclear chromosome segregation
C2H95_11625	COG0552	protein localization to endoplasmic reticulum
C2H95_11635	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C2H95_11640	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2H95_11645	COG0228	four-way junction DNA binding
C2H95_11650	COG1837	Belongs to the UPF0109 family
C2H95_11660	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2H95_11665	COG0336	Belongs to the RNA methyltransferase TrmD family
C2H95_11670	COG0335	large ribosomal subunit rRNA binding
C2H95_11675	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2H95_11680	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2H95_11690	COG2257	FlhB HrpN YscU SpaS Family
C2H95_11695	COG0045	succinate-CoA ligase (ADP-forming) activity
C2H95_11700	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2H95_11705	COG0758	DNA mediated transformation
C2H95_11710	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2H95_11715	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C2H95_11720	COG4974	Belongs to the 'phage' integrase family
C2H95_11725	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C2H95_11730	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C2H95_11735	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C2H95_11740	COG1815	bacterial-type flagellum-dependent cell motility
C2H95_11745	COG1558	bacterial-type flagellum-dependent cell motility
C2H95_11750	COG1677	Flagellar hook-basal body complex protein FliE
C2H95_11755	COG1766	The M ring may be actively involved in energy transduction
C2H95_11760	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2H95_11765	COG1317	bacterial-type flagellum organization
C2H95_11770	COG1157	protein secretion by the type III secretion system
C2H95_11775	COG2882	bacterial-type flagellum organization
C2H95_11780	COG3334	PFAM MgtE intracellular
C2H95_11785	COG3144	bacterial-type flagellum assembly
C2H95_11790	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C2H95_11795	COG4786	Flagellar basal body rod
C2H95_11800	COG1582	Flagellar protein (FlbD)
C2H95_11805	COG1580	Controls the rotational direction of flagella during chemotaxis
C2H95_11810	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2H95_11815	COG1776	CheC inhibitor of MCP methylation
C2H95_11815	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2H95_11820	COG2201	protein-glutamate methylesterase activity
C2H95_11825	COG3190	flagellar
C2H95_11830	COG1338	Plays a role in the flagellum-specific transport system
C2H95_11835	COG1987	bacterial-type flagellum assembly
C2H95_11840	COG1684	flagellar biosynthetic protein fliR
C2H95_11845	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2H95_11850	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2H95_11855	COG1419	protein localization to endoplasmic reticulum
C2H95_11860	COG0455	bacterial-type flagellum organization
C2H95_11865	COG2201	protein-glutamate methylesterase activity
C2H95_11870	COG2198	Histidine kinase
C2H95_11870	COG0643	Histidine kinase
C2H95_11875	COG0835	chemotaxis
C2H95_11880	COG1776	CheC inhibitor of MCP methylation
C2H95_11885	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C2H95_11890	COG1191	sigma factor activity
C2H95_11900	COG0052	Belongs to the universal ribosomal protein uS2 family
C2H95_11905	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C2H95_11910	COG0528	UMP kinase activity
C2H95_11915	COG0233	cytoplasmic translational termination
C2H95_11920	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C2H95_11925	COG4589	Belongs to the CDS family
C2H95_11930	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2H95_11935	COG0750	zinc metalloprotease
C2H95_11940	COG0442	prolyl-tRNA aminoacylation
C2H95_11945	COG2176	DNA-directed DNA polymerase activity
C2H95_11950	COG0779	Required for maturation of 30S ribosomal subunits
C2H95_11955	COG0195	Participates in both transcription termination and antitermination
C2H95_11960	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C2H95_11965	COG1358	cellular component organization or biogenesis
C2H95_11970	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C2H95_11975	COG1550	Protein conserved in bacteria
C2H95_11980	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C2H95_11985	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C2H95_11990	COG0196	riboflavin kinase activity
C2H95_11995	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C2H95_12000	COG1185	polyribonucleotide nucleotidyltransferase activity
C2H95_12005	COG0726	polysaccharide deacetylase
C2H95_12010	COG0612	Peptidase, M16
C2H95_12015	COG1873	PFAM PRC-barrel domain
C2H95_12020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2H95_12025	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2H95_12030	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2H95_12035	COG0527	aspartate kinase activity
C2H95_12040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2H95_12045	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2H95_12050	COG0740	serine-type endopeptidase activity
C2H95_12060	COG4980	gas vesicle protein
C2H95_12060	COG1674	ftsk spoiiie
C2H95_12065	COG2188	Transcriptional regulator
C2H95_12070	COG2814	Major facilitator Superfamily
C2H95_12075	COG0612	Peptidase, M16
C2H95_12080	COG0612	Peptidase, M16
C2H95_12085	COG0300	oxidoreductase activity
C2H95_12100	COG1426	Protein conserved in bacteria
C2H95_12105	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2H95_12110	COG1058	Belongs to the CinA family
C2H95_12110	COG1546	Belongs to the CinA family
C2H95_12115	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C2H95_12120	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2H95_12125	COG1418	mRNA catabolic process
C2H95_12130	COG1692	metallophosphoesterase
C2H95_12135	COG2359	stage V sporulation protein S
C2H95_12140	COG1063	alcohol dehydrogenase
C2H95_12145	COG0156	8-amino-7-oxononanoate synthase activity
C2H95_12150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2H95_12155	COG4550	Control of competence regulator ComK, YlbF/YmcA
C2H95_12165	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C2H95_12170	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2H95_12185	COG3226	Transcriptional regulator
C2H95_12190	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H95_12200	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2H95_12205	COG3321	synthase
C2H95_12210	COG2070	2-Nitropropane dioxygenase
C2H95_12210	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2H95_12215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H95_12220	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2H95_12225	COG3425	synthase
C2H95_12230	COG1024	Enoyl-CoA hydratase
C2H95_12235	COG1024	Enoyl-CoA hydratase
C2H95_12240	COG0300	oxidoreductase activity
C2H95_12240	COG0318	PFAM AMP-dependent synthetase and ligase
C2H95_12240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H95_12240	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_12240	COG3321	synthase
C2H95_12245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H95_12245	COG0300	oxidoreductase activity
C2H95_12245	COG4221	oxidoreductase activity
C2H95_12245	COG3321	synthase
C2H95_12250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H95_12250	COG3321	synthase
C2H95_12250	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_12250	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H95_12250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H95_12255	COG4221	oxidoreductase activity
C2H95_12255	COG3321	synthase
C2H95_12255	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_12255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H95_12260	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C2H95_12260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2H95_12260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H95_12260	COG3321	synthase
C2H95_12265	COG2124	cytochrome p450
C2H95_12275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H95_12280	COG1404	Belongs to the peptidase S8 family
C2H95_12290	COG4195	phage-related replication protein
C2H95_12295	COG1764	response to oxidative stress
C2H95_12300	COG2076	Multidrug Resistance protein
C2H95_12305	COG2076	Multidrug Resistance protein
C2H95_12320	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C2H95_12325	COG1923	regulation of RNA biosynthetic process
C2H95_12340	COG1780	Probably involved in ribonucleotide reductase function
C2H95_12345	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2H95_12350	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2H95_12355	COG4112	unkown
C2H95_12360	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H95_12370	COG0464	growth
C2H95_12375	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2H95_12380	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
C2H95_12385	COG0789	Transcriptional regulator
C2H95_12390	COG0174	glutamine synthetase
C2H95_12395	COG4974	Belongs to the 'phage' integrase family
C2H95_12405	COG1396	sequence-specific DNA binding
C2H95_12410	COG1917	Cupin 2, conserved barrel domain protein
C2H95_12410	COG1396	sequence-specific DNA binding
C2H95_12480	COG0582	viral genome integration into host DNA
C2H95_12575	COG5280	Phage tail tape measure protein TP901
C2H95_12575	COG3953	SLT domain
C2H95_12585	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2H95_12615	COG4824	toxin secretion phage lysis holin
C2H95_12620	COG3409	Peptidoglycan-binding domain 1 protein
C2H95_12620	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2H95_12620	COG1388	LysM domain
C2H95_12630	COG5444	nuclease activity
C2H95_12660	COG4282	regulation of fungal-type cell wall biogenesis
C2H95_12670	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H95_12705	COG2211	Major facilitator Superfamily
C2H95_12710	COG3507	Belongs to the glycosyl hydrolase 43 family
C2H95_12715	COG1940	carbohydrate kinase activity
C2H95_12720	COG2115	Belongs to the xylose isomerase family
C2H95_12725	COG1070	Carbohydrate kinase
C2H95_12735	COG1525	nuclease
C2H95_12740	COG2814	Major facilitator Superfamily
C2H95_12745	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2H95_12755	COG0756	dUTP diphosphatase activity
C2H95_12790	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2H95_12800	COG3832	glyoxalase III activity
C2H95_12810	COG0697	spore germination
C2H95_12815	COG0531	amino acid
C2H95_12845	COG4195	phage-related replication protein
C2H95_12855	COG0346	lactoylglutathione lyase activity
C2H95_12865	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2H95_12870	COG1388	LysM domain
C2H95_12875	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2H95_12880	COG4224	UPF0291 protein
C2H95_12885	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2H95_12895	COG3763	UPF0154 protein
C2H95_12905	COG0785	Cytochrome C biogenesis protein
C2H95_12910	COG2201	protein-glutamate methylesterase activity
C2H95_12915	COG4846	Membrane protein involved in cytochrome C biogenesis
C2H95_12925	COG0071	Belongs to the small heat shock protein (HSP20) family
C2H95_12940	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2H95_12945	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H95_12965	COG0824	Thioesterase
C2H95_12975	COG4841	protein insertion into membrane
C2H95_12980	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C2H95_12985	COG1832	CoA-binding protein
C2H95_12990	COG0187	DNA topoisomerase II activity
C2H95_12995	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2H95_13005	COG1115	amino acid carrier protein
C2H95_13010	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C2H95_13020	COG5520	Belongs to the glycosyl hydrolase 30 family
C2H95_13025	COG3507	Belongs to the glycosyl hydrolase 43 family
C2H95_13030	COG2246	polysaccharide biosynthetic process
C2H95_13035	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2H95_13040	COG0586	Pfam SNARE associated Golgi protein
C2H95_13045	COG2404	hydrolase activity, acting on ester bonds
C2H95_13050	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2H95_13055	COG1024	Enoyl-CoA hydratase
C2H95_13060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2H95_13065	COG0511	ligase activity, forming carbon-carbon bonds
C2H95_13070	COG0439	Biotin carboxylase
C2H95_13075	COG0318	PFAM AMP-dependent synthetase and ligase
C2H95_13080	COG1960	acyl-CoA dehydrogenase activity
C2H95_13085	COG1649	PFAM Uncharacterised BCR, COG1649
C2H95_13095	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C2H95_13095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H95_13100	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H95_13105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H95_13110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H95_13115	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H95_13120	COG2027	D-alanyl-D-alanine carboxypeptidase
C2H95_13125	COG2017	converts alpha-aldose to the beta-anomer
C2H95_13130	COG0534	Mate efflux family protein
C2H95_13145	COG0582	viral genome integration into host DNA
C2H95_13150	COG0166	Belongs to the GPI family
C2H95_13155	COG0405	Gamma-glutamyltransferase
C2H95_13160	COG0583	DNA-binding transcription factor activity
C2H95_13165	COG0604	alcohol dehydrogenase
C2H95_13170	COG0493	'glutamate synthase
C2H95_13175	COG0067	glutamate synthase
C2H95_13175	COG0070	glutamate synthase
C2H95_13175	COG0069	glutamate synthase activity
C2H95_13180	COG0583	DNA-binding transcription factor activity
C2H95_13185	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C2H95_13190	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2H95_13200	COG0300	oxidoreductase activity
C2H95_13205	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
C2H95_13215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H95_13230	COG1131	(ABC) transporter
C2H95_13240	COG2814	Major facilitator Superfamily
C2H95_13245	COG1070	Carbohydrate kinase
C2H95_13250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2H95_13255	COG0243	molybdopterin cofactor binding
C2H95_13265	COG2814	Major facilitator Superfamily
C2H95_13270	COG0673	inositol 2-dehydrogenase activity
C2H95_13275	COG1082	Xylose isomerase domain protein TIM barrel
C2H95_13280	COG1609	Transcriptional regulator
C2H95_13300	COG0840	transmembrane signaling receptor activity
C2H95_13300	COG5278	phosphoserine phosphatase activity
C2H95_13305	COG2368	4-hydroxyphenylacetate
C2H95_13310	COG4305	rare lipoprotein A
C2H95_13315	COG3619	membrane
C2H95_13320	COG3866	Pectate lyase
C2H95_13325	COG2135	peptidase activity
C2H95_13335	COG2140	Oxalate decarboxylase
C2H95_13355	COG2720	vancomycin resistance protein
C2H95_13365	COG3655	Transcriptional regulator
C2H95_13370	COG3739	integral membrane protein
C2H95_13375	COG0583	DNA-binding transcription factor activity
C2H95_13380	COG0697	spore germination
C2H95_13390	COG0693	protein deglycase activity
C2H95_13395	COG2367	Beta-lactamase
C2H95_13415	COG3848	Pyruvate phosphate dikinase
C2H95_13415	COG0574	Belongs to the PEP-utilizing enzyme family
C2H95_13420	COG0726	polysaccharide deacetylase
C2H95_13430	COG2314	TM2 domain
C2H95_13460	COG3655	Transcriptional regulator
C2H95_13495	COG0457	Tetratricopeptide repeat
C2H95_13505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2H95_13515	COG4282	regulation of fungal-type cell wall biogenesis
C2H95_13520	COG1231	oxidoreductase activity
C2H95_13525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H95_13530	COG0662	Cupin 2, conserved barrel domain protein
C2H95_13530	COG2207	Transcriptional regulator
C2H95_13535	COG0456	acetyltransferase
C2H95_13540	COG1309	transcriptional regulator
C2H95_13545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H95_13550	COG3708	Transcriptional regulator
C2H95_13555	COG2378	regulation of single-species biofilm formation
C2H95_13565	COG0640	Transcriptional regulator
C2H95_13570	COG0741	lytic transglycosylase activity
C2H95_13575	COG2322	membrane
C2H95_13590	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2H95_13595	COG3239	Fatty acid desaturase
C2H95_13600	COG4585	Histidine kinase
C2H95_13605	COG2197	response regulator
C2H95_13610	COG1388	LysM domain
C2H95_13610	COG3584	3D domain protein
C2H95_13615	COG0514	ATP-dependent DNA helicase (RecQ)
C2H95_13630	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2H95_13635	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2H95_13650	COG0071	Belongs to the small heat shock protein (HSP20) family
C2H95_13675	COG1012	belongs to the aldehyde dehydrogenase family
C2H95_13680	COG1657	PFAM Prenyltransferase squalene oxidase
C2H95_13685	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2H95_13690	COG0733	neurotransmitter:sodium symporter activity
C2H95_13695	COG0385	Bile acid
C2H95_13700	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H95_13705	COG0567	Dehydrogenase, E1 component
C2H95_13710	COG4548	von Willebrand factor, type A
C2H95_13715	COG0714	Associated with various cellular activities
C2H95_13720	COG2032	superoxide dismutase activity
C2H95_13725	COG0791	NLP P60 protein
C2H95_13725	COG1388	LysM domain
C2H95_13730	COG1819	glycosyl
C2H95_13735	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C2H95_13740	COG0534	Mate efflux family protein
C2H95_13745	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H95_13750	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2H95_13755	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2H95_13765	COG2962	Rard protein
C2H95_13780	COG2610	gluconate transmembrane transporter activity
C2H95_13785	COG1942	4-Oxalocrotonate Tautomerase
C2H95_13790	COG1733	regulation of RNA biosynthetic process
C2H95_13795	COG0778	Nitroreductase
C2H95_13800	COG0400	carboxylic ester hydrolase activity
C2H95_13805	COG0346	lactoylglutathione lyase activity
C2H95_13815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H95_13820	COG3409	Peptidoglycan-binding domain 1 protein
C2H95_13820	COG0793	Belongs to the peptidase S41A family
C2H95_13825	COG2226	methyltransferase
C2H95_13835	COG1876	peptidase activity
C2H95_13840	COG0813	purine-nucleoside phosphorylase activity
C2H95_13855	COG0671	phosphoesterase, PA-phosphatase related
C2H95_13880	COG4479	Belongs to the UPF0346 family
C2H95_13890	COG1509	lysine 2,3-aminomutase activity
C2H95_13895	COG0456	acetyltransferase
C2H95_13900	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2H95_13905	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2H95_13910	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2H95_13915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2H95_13925	COG0456	acetyltransferase
C2H95_13930	COG0463	Glycosyl transferase, family 2
C2H95_13945	COG4641	Protein conserved in bacteria
C2H95_13950	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
C2H95_13955	COG1086	Polysaccharide biosynthesis protein
C2H95_13960	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2H95_13965	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2H95_13970	COG1846	Transcriptional regulator
C2H95_13975	COG0534	Mate efflux family protein
C2H95_13985	COG4698	Protein conserved in bacteria
C2H95_13990	COG2755	lipolytic protein G-D-S-L family
C2H95_13995	COG1999	signal sequence binding
C2H95_14005	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2H95_14010	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2H95_14015	COG1272	protein, Hemolysin III
C2H95_14020	COG0204	Acyl-transferase
C2H95_14025	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2H95_14030	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2H95_14040	COG2521	methyltransferase
C2H95_14040	COG2136	Putative SAM-dependent methyltransferase
C2H95_14050	COG0129	dihydroxy-acid dehydratase activity
C2H95_14055	COG1413	lyase activity
C2H95_14060	COG1418	mRNA catabolic process
C2H95_14065	COG0386	Belongs to the glutathione peroxidase family
C2H95_14070	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C2H95_14075	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2H95_14080	COG1278	Cold shock
C2H95_14100	COG0328	RNA-DNA hybrid ribonuclease activity
C2H95_14105	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2H95_14110	COG0328	RNA-DNA hybrid ribonuclease activity
C2H95_14120	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2H95_14135	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2H95_14145	COG1755	Isoprenylcysteine carboxyl methyltransferase
C2H95_14150	COG3424	synthase
C2H95_14155	COG2233	PERMEase
C2H95_14160	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2H95_14165	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C2H95_14175	COG0800	Aldolase
C2H95_14180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H95_14185	COG1609	Transcriptional regulator
C2H95_14190	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C2H95_14195	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_14200	COG1199	ATP-dependent helicase activity
C2H95_14215	COG0116	Belongs to the methyltransferase superfamily
C2H95_14230	COG4474	Belongs to the UPF0398 family
C2H95_14240	COG3359	exonuclease
C2H95_14245	COG1111	helicase
C2H95_14245	COG1205	dead DEAH box helicase
C2H95_14250	COG2190	(PTS) system
C2H95_14255	COG0071	Belongs to the small heat shock protein (HSP20) family
C2H95_14290	COG3331	DNA recombination
C2H95_14295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2H95_14295	COG4499	WXG100 protein secretion system (Wss), protein YukC
C2H95_14305	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2H95_14310	COG3935	DnaD domain protein
C2H95_14315	COG0017	Asparaginyl-tRNA synthetase
C2H95_14320	COG0436	Aminotransferase
C2H95_14325	COG5353	protein conserved in bacteria
C2H95_14335	COG1199	ATP-dependent helicase activity
C2H95_14335	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2H95_14340	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C2H95_14345	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C2H95_14350	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C2H95_14355	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C2H95_14355	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C2H95_14360	COG0617	tRNA 3'-terminal CCA addition
C2H95_14365	COG0438	transferase activity, transferring glycosyl groups
C2H95_14370	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2H95_14375	COG1803	Methylglyoxal synthase
C2H95_14380	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C2H95_14385	COG1694	Mazg nucleotide pyrophosphohydrolase
C2H95_14390	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H95_14400	COG4347	Protein of unknown function (DUF1405)
C2H95_14405	COG2010	Cytochrome c
C2H95_14405	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2H95_14410	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2H95_14415	COG0723	plastoquinol--plastocyanin reductase activity
C2H95_14425	COG5582	Belongs to the UPF0302 family
C2H95_14430	COG0457	Tetratricopeptide repeat
C2H95_14435	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C2H95_14440	COG0287	Prephenate dehydrogenase
C2H95_14450	COG0159	tryptophan synthase activity
C2H95_14455	COG0133	tryptophan synthase activity
C2H95_14460	COG0135	phosphoribosylanthranilate isomerase activity
C2H95_14470	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2H95_14475	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2H95_14480	COG4401	Chorismate mutase type I
C2H95_14485	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C2H95_14490	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C2H95_14495	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2H95_14500	COG0105	UTP biosynthetic process
C2H95_14505	COG0142	geranyltranstransferase activity
C2H95_14510	COG2226	methyltransferase
C2H95_14515	COG0142	geranyltranstransferase activity
C2H95_14525	COG0302	gtp cyclohydrolase
C2H95_14530	COG0776	regulation of translation
C2H95_14535	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2H95_14550	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C2H95_14555	COG1160	GTP binding
C2H95_14580	COG1304	FMN binding
C2H95_14585	COG0539	negative regulation of cytoplasmic translation
C2H95_14590	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C2H95_14600	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C2H95_14605	COG2959	enzyme of heme biosynthesis
C2H95_14610	COG3409	Peptidoglycan-binding domain 1 protein
C2H95_14610	COG3773	Cell wall hydrolase
C2H95_14615	COG2339	peptidase activity
C2H95_14620	COG0492	ferredoxin-NADP+ reductase activity
C2H95_14625	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2H95_14630	COG4862	establishment of competence for transformation
C2H95_14635	COG1408	metallophosphoesterase
C2H95_14645	COG1388	LysM domain
C2H95_14650	COG1266	CAAX protease self-immunity
C2H95_14655	COG0514	ATP-dependent DNA helicase (RecQ)
C2H95_14660	COG4955	Helix-turn-helix domain
C2H95_14665	COG1141	Ferredoxin
C2H95_14670	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C2H95_14675	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2H95_14680	COG0710	3-dehydroquinate dehydratase activity
C2H95_14690	COG1595	DNA-templated transcription, initiation
C2H95_14695	COG5002	protein histidine kinase activity
C2H95_14700	COG0745	RESPONSE REGULATOR receiver
C2H95_14705	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2H95_14710	COG1333	cytochrome c biogenesis protein
C2H95_14715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H95_14720	COG1187	pseudouridine synthase activity
C2H95_14725	COG0700	Nucleoside recognition
C2H95_14730	COG2715	membrane protein required for spore maturation
C2H95_14735	COG1686	Belongs to the peptidase S11 family
C2H95_14745	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C2H95_14750	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C2H95_14755	COG1547	Domain of unknown function (DUF309)
C2H95_14760	COG0456	acetyltransferase
C2H95_14765	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C2H95_14770	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2H95_14770	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2H95_14775	COG0307	riboflavin synthase, alpha
C2H95_14780	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2H95_14780	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2H95_14790	COG0681	Belongs to the peptidase S26 family
C2H95_14800	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
C2H95_14810	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2H95_14820	COG4086	secreted protein
C2H95_14825	COG0019	diaminopimelate decarboxylase activity
C2H95_14830	COG0697	spore germination
C2H95_14845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2H95_14865	COG1191	sigma factor activity
C2H95_14870	COG2172	sigma factor antagonist activity
C2H95_14875	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H95_14880	COG1686	Belongs to the peptidase S11 family
C2H95_14885	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C2H95_14890	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C2H95_14895	COG4974	Belongs to the 'phage' integrase family
C2H95_14905	COG0735	belongs to the Fur family
C2H95_14910	COG1300	Membrane
C2H95_14920	COG0281	malic enzyme
C2H95_14925	COG1757	Na H antiporter
C2H95_14930	COG1027	Aspartate ammonia-lyase
C2H95_14935	COG0252	asparaginase activity
C2H95_14940	COG1396	sequence-specific DNA binding
C2H95_14945	COG1379	DNA repair
C2H95_14950	COG0494	nUDIX hydrolase
C2H95_14960	COG0667	Aldo Keto reductase
C2H95_14970	COG1073	alpha beta
C2H95_14980	COG4918	Iron-sulphur cluster biosynthesis
C2H95_14985	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2H95_14985	COG0456	acetyltransferase
C2H95_14990	COG2329	Antibiotic biosynthesis monooxygenase
C2H95_14995	COG0456	acetyltransferase
C2H95_15005	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2H95_15015	COG2211	Major facilitator Superfamily
C2H95_15025	COG0346	lactoylglutathione lyase activity
C2H95_15030	COG1072	(Pantothenic acid kinase))
C2H95_15035	COG3048	D-serine ammonia-lyase activity
C2H95_15040	COG0300	oxidoreductase activity
C2H95_15045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H95_15050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2H95_15055	COG4187	Peptidase family M20/M25/M40
C2H95_15060	COG1902	pentaerythritol trinitrate reductase activity
C2H95_15065	COG0596	Alpha beta hydrolase
C2H95_15075	COG1234	tRNA 3'-trailer cleavage
C2H95_15080	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2H95_15085	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C2H95_15090	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2H95_15100	COG0706	membrane insertase activity
C2H95_15105	COG3361	conserved protein (COG2071)
C2H95_15110	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2H95_15115	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2H95_15120	COG0346	lactoylglutathione lyase activity
C2H95_15125	COG1376	ErfK ybiS ycfS ynhG family protein
C2H95_15130	COG4129	membrane
C2H95_15135	COG1126	abc transporter atp-binding protein
C2H95_15140	COG0765	amino acid transport
C2H95_15145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H95_15155	COG1597	lipid kinase activity
C2H95_15160	COG2814	Major facilitator Superfamily
C2H95_15165	COG4978	Transcriptional regulator
C2H95_15165	COG0789	Transcriptional regulator
C2H95_15170	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H95_15175	COG0022	dehydrogenase e1 component
C2H95_15180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2H95_15185	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2H95_15190	COG3426	butyrate kinase activity
C2H95_15195	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2H95_15200	COG0280	phosphate acetyltransferase
C2H95_15205	COG3290	protein histidine kinase activity
C2H95_15205	COG3829	transcription factor binding
C2H95_15215	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C2H95_15220	COG2079	MmgE PrpD family protein
C2H95_15225	COG0372	Belongs to the citrate synthase family
C2H95_15230	COG1960	acyl-CoA dehydrogenase activity
C2H95_15235	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2H95_15240	COG0183	Belongs to the thiolase family
C2H95_15245	COG0584	glycerophosphoryl diester phosphodiesterase
C2H95_15250	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H95_15260	COG1902	pentaerythritol trinitrate reductase activity
C2H95_15265	COG0745	RESPONSE REGULATOR receiver
C2H95_15270	COG0750	zinc metalloprotease
C2H95_15275	COG0497	DNA recombination
C2H95_15280	COG1438	arginine binding
C2H95_15285	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C2H95_15290	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2H95_15295	COG0142	geranyltranstransferase activity
C2H95_15300	COG1722	exodeoxyribonuclease VII activity
C2H95_15305	COG1570	exodeoxyribonuclease VII activity
C2H95_15310	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C2H95_15315	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2H95_15320	COG1302	Protein conserved in bacteria
C2H95_15325	COG0439	Biotin carboxylase
C2H95_15330	COG0511	ligase activity, forming carbon-carbon bonds
C2H95_15370	COG3854	ATPases associated with a variety of cellular activities
C2H95_15380	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C2H95_15385	COG0006	proline dipeptidase activity
C2H95_15390	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C2H95_15400	COG3872	metal-dependent enzyme
C2H95_15410	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2H95_15415	COG1321	iron dependent repressor
C2H95_15420	COG0095	Lipoate-protein ligase
C2H95_15425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2H95_15430	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2H95_15435	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2H95_15440	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2H95_15445	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2H95_15465	COG1396	sequence-specific DNA binding
C2H95_15475	COG0681	Belongs to the peptidase S26 family
C2H95_15500	COG4940	Competence protein ComGF
C2H95_15510	COG4970	Tfp pilus assembly protein FimT
C2H95_15515	COG4537	Required for transformation and DNA binding
C2H95_15520	COG1459	type II secretion system
C2H95_15525	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2H95_15530	COG0517	IMP dehydrogenase activity
C2H95_15535	COG0598	Magnesium transport protein CorA
C2H95_15540	COG1253	flavin adenine dinucleotide binding
C2H95_15545	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H95_15555	COG1393	Belongs to the ArsC family
C2H95_15565	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H95_15575	COG0011	TIGRFAM Protein of
C2H95_15585	COG2866	Carboxypeptidase
C2H95_15590	COG1368	sulfuric ester hydrolase activity
C2H95_15595	COG1940	carbohydrate kinase activity
C2H95_15600	COG4483	Protein conserved in bacteria
C2H95_15605	COG0457	Tetratricopeptide repeat
C2H95_15605	COG0705	Rhomboid family
C2H95_15615	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2H95_15625	COG0438	transferase activity, transferring glycosyl groups
C2H95_15640	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2H95_15645	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2H95_15650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2H95_15655	COG0581	inorganic phosphate transmembrane transporter activity
C2H95_15660	COG0573	inorganic phosphate transmembrane transporter activity
C2H95_15665	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2H95_15670	COG0768	penicillin binding
C2H95_15675	COG0477	Major facilitator Superfamily
C2H95_15680	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2H95_15685	COG2839	Protein conserved in bacteria
C2H95_15690	COG5521	maltodextrose utilization protein MalA
C2H95_15695	COG1388	LysM domain
C2H95_15700	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C2H95_15705	COG4709	membrane
C2H95_15710	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
C2H95_15715	COG0735	belongs to the Fur family
C2H95_15720	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H95_15730	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C2H95_15735	COG0513	Belongs to the DEAD box helicase family
C2H95_15745	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C2H95_15750	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2H95_15755	COG2384	SAM-dependent methyltransferase
C2H95_15760	COG2010	Cytochrome c
C2H95_15770	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2H95_15775	COG0358	DNA primase activity
C2H95_15780	COG1671	Belongs to the UPF0178 family
C2H95_15785	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C2H95_15790	COG0517	IMP dehydrogenase activity
C2H95_15795	COG0751	glycine-tRNA ligase activity
C2H95_15800	COG0752	glycyl-tRNA synthetase alpha subunit
C2H95_15805	COG1381	Involved in DNA repair and RecF pathway recombination
C2H95_15815	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C2H95_15820	COG0295	cytidine deaminase activity
C2H95_15825	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2H95_15830	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C2H95_15835	COG1480	7TM receptor with intracellular HD hydrolase
C2H95_15840	COG1702	phosphate starvation-inducible protein PhoH
C2H95_15845	COG0561	phosphatase activity
C2H95_15860	COG4864	UPF0365 protein
C2H95_15865	COG1030	water channel activity
C2H95_15870	COG1610	YqeY-like protein
C2H95_15880	COG1283	sodium-dependent phosphate transmembrane transporter activity
C2H95_15885	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2H95_15890	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2H95_15895	COG2264	protein methyltransferase activity
C2H95_15900	COG0484	heat shock protein binding
C2H95_15905	COG0443	Heat shock 70 kDa protein
C2H95_15910	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C2H95_15915	COG1420	regulation of RNA biosynthetic process
C2H95_15920	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2H95_15925	COG0481	GTPase activity
C2H95_15935	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H95_15940	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C2H95_15945	COG0268	Binds directly to 16S ribosomal RNA
C2H95_15950	COG1466	dna polymerase III delta subunit
C2H95_15960	COG0658	competence protein
C2H95_15960	COG2333	competence protein COMEC
C2H95_15965	COG2131	deaminase
C2H95_15970	COG1555	photosystem II stabilization
C2H95_15970	COG1596	polysaccharide export
C2H95_15975	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2H95_15980	COG2226	methyltransferase
C2H95_15985	COG0799	negative regulation of ribosome biogenesis
C2H95_15990	COG1713	HD superfamily hydrolase involved in NAD metabolism
C2H95_15995	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2H95_16000	COG1534	Rna-binding protein
C2H95_16005	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2H95_16010	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2H95_16015	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C2H95_16025	COG2755	lipolytic protein G-D-S-L family
C2H95_16030	COG3409	Peptidoglycan-binding domain 1 protein
C2H95_16030	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2H95_16035	COG0398	Pfam SNARE associated Golgi protein
C2H95_16040	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C2H95_16050	COG3209	COG3209 Rhs family protein
C2H95_16065	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2H95_16085	COG0457	Tetratricopeptide repeat
C2H95_16100	COG5444	nuclease activity
C2H95_16110	COG2732	(Barnase) inhibitor
C2H95_16125	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2H95_16125	COG3409	Peptidoglycan-binding domain 1 protein
C2H95_16140	COG5484	DNA packaging
C2H95_16165	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C2H95_16175	COG1484	DNA-dependent DNA replication
C2H95_16180	COG3935	DnaD domain protein
C2H95_16185	COG3723	Recombinational DNA repair protein, rece pathway
C2H95_16190	COG5377	YqaJ viral recombinase family
C2H95_16215	COG1476	TRANSCRIPTIONal
C2H95_16220	COG3620	sequence-specific DNA binding
C2H95_16235	COG2856	Zn peptidase
C2H95_16245	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2H95_16255	COG3223	Belongs to the PsiE family
C2H95_16260	COG0642	Histidine kinase
C2H95_16260	COG5002	protein histidine kinase activity
C2H95_16265	COG0745	RESPONSE REGULATOR receiver
C2H95_16270	COG2311	Membrane
C2H95_16275	COG0454	-acetyltransferase
C2H95_16280	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2H95_16290	COG0730	response to heat
C2H95_16295	COG0425	Belongs to the sulfur carrier protein TusA family
C2H95_16300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H95_16300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2H95_16310	COG0425	Belongs to the sulfur carrier protein TusA family
C2H95_16310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2H95_16320	COG2210	Belongs to the sulfur carrier protein TusA family
C2H95_16325	COG1937	Protein conserved in bacteria
C2H95_16340	COG0662	Cupin 2, conserved barrel domain protein
C2H95_16360	COG0789	Transcriptional regulator
C2H95_16360	COG4978	Transcriptional regulator
C2H95_16365	COG2814	Major facilitator Superfamily
C2H95_16370	COG0456	acetyltransferase
C2H95_16375	COG1253	flavin adenine dinucleotide binding
C2H95_16385	COG0697	spore germination
C2H95_16390	COG0583	DNA-binding transcription factor activity
C2H95_16395	COG2072	flavoprotein involved in K transport
C2H95_16400	COG1230	cation diffusion facilitator family transporter
C2H95_16410	COG1114	Component of the transport system for branched-chain amino acids
C2H95_16415	COG1687	branched-chain amino acid
C2H95_16420	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C2H95_16425	COG1522	sequence-specific DNA binding
C2H95_16430	COG2732	(Barnase) inhibitor
C2H95_16435	COG2124	cytochrome p450
C2H95_16450	COG1335	isochorismatase
C2H95_16465	COG2318	DinB family
C2H95_16475	COG2070	2-Nitropropane dioxygenase
C2H95_16490	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2H95_16505	COG3443	Belongs to the bacterial solute-binding protein 9 family
C2H95_16510	COG1595	DNA-templated transcription, initiation
C2H95_16515	COG0667	Aldo Keto reductase
C2H95_16520	COG2851	Citrate transporter
C2H95_16525	COG0583	DNA-binding transcription factor activity
C2H95_16530	COG2828	Protein conserved in bacteria
C2H95_16535	COG3409	Peptidoglycan-binding domain 1 protein
C2H95_16540	COG5566	PFAM Mor transcription activator
C2H95_16545	COG0596	Alpha beta hydrolase
C2H95_16550	COG4991	sh3 domain protein
C2H95_16555	COG4991	sh3 domain protein
C2H95_16560	COG0346	lactoylglutathione lyase activity
C2H95_16570	COG5577	PFAM Coat F domain
C2H95_16575	COG1063	alcohol dehydrogenase
C2H95_16585	COG5577	PFAM Coat F domain
C2H95_16590	COG0789	Transcriptional regulator
C2H95_16600	COG1064	alcohol dehydrogenase
C2H95_16605	COG0693	protein deglycase activity
C2H95_16610	COG1621	beta-fructofuranosidase activity
C2H95_16615	COG3716	PTS system mannose fructose sorbose family IID component
C2H95_16620	COG3715	PTS system
C2H95_16625	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H95_16630	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H95_16635	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2H95_16635	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C2H95_16640	COG1113	amino acid transport
C2H95_16645	COG1280	lysine exporter protein (LysE YggA)
C2H95_16650	COG1378	Sugar-specific transcriptional regulator TrmB
C2H95_16655	COG1595	DNA-templated transcription, initiation
C2H95_16665	COG2755	lipolytic protein G-D-S-L family
C2H95_16665	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C2H95_16675	COG2124	cytochrome p450
C2H95_16675	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2H95_16680	COG1309	transcriptional regulator
C2H95_16685	COG2226	methyltransferase
C2H95_16695	COG2116	formate transmembrane transporter activity
C2H95_16700	COG5609	conserved protein (DUF2294)
C2H95_16705	COG3383	formate dehydrogenase (NAD+) activity
C2H95_16710	COG2427	Protein of unknown function (DUF1641)
C2H95_16720	COG0626	cystathionine gamma-synthase activity
C2H95_16725	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2H95_16730	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2H95_16735	COG2226	methyltransferase
C2H95_16750	COG0768	penicillin binding
C2H95_16755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2H95_16760	COG0572	uridine kinase
C2H95_16765	COG0826	peptidase U32
C2H95_16770	COG0826	peptidase U32
C2H95_16775	COG4122	O-methyltransferase activity
C2H95_16780	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2H95_16785	COG3906	Belongs to the UPF0473 family
C2H95_16790	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C2H95_16795	COG4472	Bacterial protein of unknown function (DUF965)
C2H95_16800	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2H95_16805	COG0628	permease
C2H95_16810	COG1126	abc transporter atp-binding protein
C2H95_16815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H95_16820	COG0765	amino acid transport
C2H95_16825	COG0765	amino acid transport
C2H95_16840	COG3881	PFAM PRC-barrel domain
C2H95_16845	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2H95_16850	COG0457	Tetratricopeptide repeat
C2H95_16855	COG0482	sulfurtransferase activity
C2H95_16860	COG1104	cysteine desulfurase activity
C2H95_16865	COG1959	2 iron, 2 sulfur cluster binding
C2H95_16870	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2H95_16875	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2H95_16885	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C2H95_16890	COG0124	histidyl-tRNA synthetase
C2H95_16900	COG4991	sh3 domain protein
C2H95_16900	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H95_16900	COG3103	Sh3 type 3 domain protein
C2H95_16905	COG1490	D-aminoacyl-tRNA deacylase activity
C2H95_16910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2H95_16915	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2H95_16920	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2H95_16920	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C2H95_16925	COG5416	Lipopolysaccharide assembly protein A domain
C2H95_16930	COG0490	domain, Protein
C2H95_16935	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2H95_16935	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2H95_16945	COG2244	polysaccharide biosynthetic process
C2H95_16950	COG2323	membrane
C2H95_16960	COG1862	Preprotein translocase
C2H95_16965	COG0343	queuine tRNA-ribosyltransferase activity
C2H95_16970	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C2H95_16980	COG2255	four-way junction helicase activity
C2H95_16985	COG0632	four-way junction helicase activity
C2H95_16995	COG2814	Major facilitator Superfamily
C2H95_17000	COG0673	inositol 2-dehydrogenase activity
C2H95_17005	COG2112	serine threonine protein kinase
C2H95_17020	COG1115	amino acid carrier protein
C2H95_17025	COG0217	transcriptional regulatory protein
C2H95_17035	COG1388	LysM domain
C2H95_17040	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2H95_17045	COG0157	Belongs to the NadC ModD family
C2H95_17050	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2H95_17055	COG1104	cysteine desulfurase activity
C2H95_17060	COG1827	regulation of RNA biosynthetic process
C2H95_17065	COG0077	Prephenate dehydratase
C2H95_17070	COG4492	Belongs to the UPF0735 family
C2H95_17075	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C2H95_17080	COG3290	protein histidine kinase activity
C2H95_17085	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C2H95_17090	COG2868	ribosomal protein
C2H95_17095	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C2H95_17100	COG1994	Peptidase M50
C2H95_17105	COG0739	heme binding
C2H95_17110	COG2894	cell division
C2H95_17115	COG0850	regulation of cytokinetic process
C2H95_17120	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2H95_17130	COG1077	Cell shape determining protein MreB Mrl
C2H95_17135	COG2003	Belongs to the UPF0758 family
C2H95_17140	COG0424	maF-like protein
C2H95_17150	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C2H95_17155	COG0285	dihydrofolate synthase activity
C2H95_17160	COG0525	valine-tRNA ligase activity
C2H95_17170	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H95_17175	COG1388	LysM domain
C2H95_17180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2H95_17185	COG0113	porphobilinogen synthase activity
C2H95_17190	COG1587	Uroporphyrinogen-III synthase
C2H95_17195	COG0181	hydroxymethylbilane synthase activity
C2H95_17200	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2H95_17205	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C2H95_17215	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C2H95_17220	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2H95_17225	COG0470	DNA polymerase III
C2H95_17225	COG1067	ATP-dependent peptidase activity
C2H95_17230	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C2H95_17235	COG0544	peptidyl-prolyl cis-trans isomerase activity
C2H95_17240	COG1477	protein flavinylation
C2H95_17240	COG0457	Tetratricopeptide repeat
C2H95_17245	COG0066	3-isopropylmalate dehydratase activity
C2H95_17250	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2H95_17255	COG0473	3-isopropylmalate dehydrogenase activity
C2H95_17260	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2H95_17265	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C2H95_17270	COG0440	acetolactate synthase activity
C2H95_17275	COG0028	Belongs to the TPP enzyme family
C2H95_17285	COG0454	-acetyltransferase
C2H95_17295	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
C2H95_17305	COG0622	Phosphoesterase
C2H95_17310	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C2H95_17315	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C2H95_17320	COG5401	PFAM Sporulation and spore germination
C2H95_17325	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2H95_17330	COG1846	Transcriptional regulator
C2H95_17335	COG2197	response regulator
C2H95_17340	COG0824	Thioesterase
C2H95_17345	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2H95_17350	COG1053	succinate dehydrogenase
C2H95_17355	COG2009	succinate dehydrogenase
C2H95_17360	COG1719	4-vinyl reductase, 4VR
C2H95_17365	COG0527	aspartate kinase activity
C2H95_17375	COG0322	excinuclease ABC activity
C2H95_17380	COG3118	belongs to the thioredoxin family
C2H95_17390	COG3534	alpha-L-arabinofuranosidase
C2H95_17395	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C2H95_17400	COG2086	electron transfer activity
C2H95_17405	COG1024	Enoyl-CoA hydratase
C2H95_17410	COG1309	transcriptional regulator
C2H95_17415	COG0318	PFAM AMP-dependent synthetase and ligase
C2H95_17420	COG3766	membrane
C2H95_17425	COG1193	negative regulation of DNA recombination
C2H95_17430	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2H95_17430	COG1796	DNA polymerase
C2H95_17435	COG1286	toxin biosynthetic process
C2H95_17440	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C2H95_17445	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2H95_17450	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H95_17450	COG0072	phenylalanine-tRNA ligase activity
C2H95_17455	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C2H95_17465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2H95_17475	COG3835	regulator
C2H95_17480	COG0277	FAD linked oxidase domain protein
C2H95_17485	COG0247	lactate metabolic process
C2H95_17490	COG0346	lactoylglutathione lyase activity
C2H95_17500	COG1966	Carbon starvation protein
C2H95_17505	COG3534	alpha-L-arabinofuranosidase
C2H95_17510	COG0395	ABC-type sugar transport system, permease component
C2H95_17515	COG1175	transmembrane transport
C2H95_17520	COG1653	transport
C2H95_17525	COG0371	Dehydrogenase
C2H95_17530	COG0647	UMP catabolic process
C2H95_17535	COG0235	Class ii aldolase
C2H95_17540	COG1069	ribulokinase activity
C2H95_17545	COG2160	L-arabinose isomerase activity
C2H95_17550	COG3507	Belongs to the glycosyl hydrolase 43 family
C2H95_17555	COG1363	Peptidase, m42
C2H95_17565	COG3326	Membrane
C2H95_17570	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C2H95_17575	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C2H95_17580	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C2H95_17590	COG1346	cytolysis
C2H95_17595	COG1380	Effector of murein hydrolase LrgA
C2H95_17600	COG3279	Response regulator of the LytR AlgR family
C2H95_17605	COG3275	phosphorelay sensor kinase activity
C2H95_17610	COG1011	Hydrolase
C2H95_17615	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2H95_17625	COG0398	Pfam SNARE associated Golgi protein
C2H95_17630	COG1484	DNA-dependent DNA replication
C2H95_17635	COG3611	Membrane attachment protein
C2H95_17640	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C2H95_17645	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C2H95_17650	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2H95_17655	COG1733	regulation of RNA biosynthetic process
C2H95_17660	COG2814	Major facilitator Superfamily
C2H95_17665	COG0656	L-ascorbic acid biosynthetic process
C2H95_17670	COG0237	dephospho-CoA kinase activity
C2H95_17675	COG1971	Probably functions as a manganese efflux pump
C2H95_17680	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C2H95_17685	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2H95_17685	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2H95_17690	COG5002	protein histidine kinase activity
C2H95_17695	COG0745	RESPONSE REGULATOR receiver
C2H95_17700	COG0039	L-malate dehydrogenase activity
C2H95_17705	COG0538	isocitrate dehydrogenase activity
C2H95_17710	COG0372	Belongs to the citrate synthase family
C2H95_17715	COG2707	UPF0756 membrane protein
C2H95_17720	COG0628	permease
C2H95_17725	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2H95_17730	COG0469	pyruvate kinase activity
C2H95_17735	COG0205	6-phosphofructokinase activity
C2H95_17740	COG0825	malonyl-CoA metabolic process
C2H95_17745	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C2H95_17750	COG0281	malic enzyme
C2H95_17755	COG0587	DNA-directed DNA polymerase activity
C2H95_17775	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C2H95_17785	COG4109	DRTGG domain
C2H95_17790	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2H95_17795	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_17805	COG0165	Argininosuccinate lyase
C2H95_17810	COG0137	argininosuccinate synthase activity
C2H95_17815	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2H95_17820	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2H95_17830	COG0827	DNA restriction-modification system
C2H95_17835	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C2H95_17840	COG3874	Sporulation protein YtfJ
C2H95_17850	COG1714	RDD family
C2H95_17855	COG0616	signal peptide processing
C2H95_17860	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2H95_17865	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C2H95_17870	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2H95_17880	COG0301	tRNA thio-modification
C2H95_17885	COG1104	cysteine desulfurase activity
C2H95_17890	COG1114	Component of the transport system for branched-chain amino acids
C2H95_17895	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C2H95_17900	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2H95_17905	COG1309	transcriptional regulator
C2H95_17910	COG1956	GAF domain-containing protein
C2H95_17915	COG2199	diguanylate cyclase activity
C2H95_17915	COG2203	Gaf domain
C2H95_17925	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C2H95_17930	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2H95_17940	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2H95_17945	COG0454	-acetyltransferase
C2H95_17950	COG0517	IMP dehydrogenase activity
C2H95_17955	COG0123	including yeast histone deacetylase and acetoin utilization protein
C2H95_17960	COG1360	Flagellar Motor Protein
C2H95_17965	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2H95_17970	COG1609	Transcriptional regulator
C2H95_17975	COG1605	Chorismate mutase
C2H95_17975	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C2H95_17980	COG3118	belongs to the thioredoxin family
C2H95_17985	COG4980	gas vesicle protein
C2H95_17990	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
C2H95_17995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2H95_18000	COG1674	ftsk spoiiie
C2H95_18005	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H95_18010	COG4848	Belongs to the UPF0354 family
C2H95_18015	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H95_18025	COG1363	Peptidase, m42
C2H95_18030	COG5584	Small secreted protein
C2H95_18035	COG0281	malic enzyme
C2H95_18040	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H95_18045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2H95_18055	COG0510	thiamine kinase activity
C2H95_18060	COG1523	belongs to the glycosyl hydrolase 13 family
C2H95_18065	COG1597	lipid kinase activity
C2H95_18075	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2H95_18080	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2H95_18085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2H95_18090	COG2252	PERMEase
C2H95_18095	COG4473	ABC transporter
C2H95_18100	COG1131	(ABC) transporter
C2H95_18105	COG1349	DNA-binding transcription factor activity
C2H95_18110	COG1187	pseudouridine synthase activity
C2H95_18115	COG2244	polysaccharide biosynthetic process
C2H95_18120	COG2081	HI0933 family
C2H95_18125	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2H95_18135	COG5578	integral membrane protein
C2H95_18140	COG0673	inositol 2-dehydrogenase activity
C2H95_18145	COG1653	transport
C2H95_18150	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2H95_18155	COG4209	transmembrane transport
C2H95_18160	COG2207	Transcriptional regulator
C2H95_18165	COG1653	transport
C2H95_18170	COG0395	ABC-type sugar transport system, permease component
C2H95_18175	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H95_18180	COG2124	cytochrome p450
C2H95_18185	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2H95_18195	COG0156	8-amino-7-oxononanoate synthase activity
C2H95_18200	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2H95_18210	COG1073	alpha beta
C2H95_18215	COG1609	Transcriptional regulator
C2H95_18220	COG1653	transport
C2H95_18225	COG1175	transmembrane transport
C2H95_18230	COG0395	ABC-type sugar transport system, permease component
C2H95_18235	COG1486	melibiose metabolic process
C2H95_18240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2H95_18245	COG0495	leucyl-tRNA aminoacylation
C2H95_18255	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H95_18255	COG2202	Pas domain
C2H95_18260	COG2814	Major facilitator Superfamily
C2H95_18265	COG2433	Pfam Transposase IS66
C2H95_18270	COG0577	efflux transmembrane transporter activity
C2H95_18275	COG1136	(ABC) transporter
C2H95_18280	COG2205	protein histidine kinase activity
C2H95_18285	COG0745	RESPONSE REGULATOR receiver
C2H95_18290	COG0577	efflux transmembrane transporter activity
C2H95_18295	COG1136	(ABC) transporter
C2H95_18310	COG1131	(ABC) transporter
C2H95_18315	COG1725	Transcriptional regulator
C2H95_18325	COG1242	4 iron, 4 sulfur cluster binding
C2H95_18330	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C2H95_18340	COG2267	carboxylic ester hydrolase activity
C2H95_18345	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2H95_18350	COG1113	amino acid transport
C2H95_18355	COG0367	asparagine synthase
C2H95_18360	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C2H95_18365	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C2H95_18375	COG1506	peptidase
C2H95_18380	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2H95_18385	COG1116	anion transmembrane transporter activity
C2H95_18390	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2H95_18395	COG0494	nUDIX hydrolase
C2H95_18400	COG4824	toxin secretion phage lysis holin
C2H95_18405	COG0783	Belongs to the Dps family
C2H95_18420	COG1854	S-ribosylhomocysteine lyase activity
C2H95_18425	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2H95_18430	COG0288	reversible hydration of carbon dioxide
C2H95_18435	COG0254	rRNA binding
C2H95_18440	COG1271	oxidase subunit
C2H95_18445	COG1294	oxidase, subunit
C2H95_18455	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2H95_18460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2H95_18460	COG1321	iron dependent repressor
C2H95_18465	COG1121	(ABC) transporter
C2H95_18470	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2H95_18475	COG4948	Mandelate Racemase Muconate Lactonizing
C2H95_18480	COG0318	PFAM AMP-dependent synthetase and ligase
C2H95_18485	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C2H95_18490	COG0596	Alpha beta hydrolase
C2H95_18495	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C2H95_18500	COG1169	isochorismate synthase
C2H95_18510	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2H95_18515	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2H95_18520	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C2H95_18525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H95_18530	COG0438	transferase activity, transferring glycosyl groups
C2H95_18540	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H95_18545	COG0438	transferase activity, transferring glycosyl groups
C2H95_18550	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H95_18555	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C2H95_18560	COG0058	SHG alpha-glucan phosphorylase activity
C2H95_18565	COG0297	glycogen (starch) synthase activity
C2H95_18570	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2H95_18575	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2H95_18580	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C2H95_18705	COG3859	Proton-coupled thiamine transporter YuaJ
C2H95_18710	COG1247	-acetyltransferase
C2H95_18715	COG2268	Band 7 protein
C2H95_18720	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2H95_18725	COG2318	DinB family
C2H95_18735	COG1454	alcohol dehydrogenase
C2H95_18740	COG1012	belongs to the aldehyde dehydrogenase family
C2H95_18745	COG1510	regulation of RNA biosynthetic process
C2H95_18755	COG0569	domain protein
C2H95_18760	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2H95_18765	COG4682	membrane
C2H95_18770	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2H95_18775	COG0477	Major facilitator Superfamily
C2H95_18780	COG5553	Cysteine dioxygenase type I
C2H95_18790	COG1968	undecaprenyl-diphosphatase activity
C2H95_18795	COG0628	permease
C2H95_18800	COG0673	inositol 2-dehydrogenase activity
C2H95_18805	COG4806	L-rhamnose isomerase
C2H95_18810	COG3254	rhamnose metabolic process
C2H95_18815	COG1070	Carbohydrate kinase
C2H95_18820	COG1349	DNA-binding transcription factor activity
C2H95_18825	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_18825	COG3347	Dehydrogenase
C2H95_18835	COG0840	transmembrane signaling receptor activity
C2H95_18840	COG0840	transmembrane signaling receptor activity
C2H95_18845	COG0840	transmembrane signaling receptor activity
C2H95_18850	COG0840	transmembrane signaling receptor activity
C2H95_18865	COG0432	Pfam Uncharacterised protein family UPF0047
C2H95_18870	COG0366	Alpha amylase catalytic
C2H95_18875	COG1253	flavin adenine dinucleotide binding
C2H95_18880	COG2738	Putative neutral zinc metallopeptidase
C2H95_18895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2H95_18910	COG0166	Belongs to the GPI family
C2H95_18915	COG1979	alcohol dehydrogenase
C2H95_18920	COG1979	alcohol dehydrogenase
C2H95_18925	COG2155	Conserved Protein
C2H95_18930	COG1098	S1 RNA binding domain
C2H95_18935	COG0436	Aminotransferase
C2H95_18940	COG1522	sequence-specific DNA binding
C2H95_18945	COG2267	carboxylic ester hydrolase activity
C2H95_18955	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2H95_18960	COG2205	protein histidine kinase activity
C2H95_18970	COG5018	Exonuclease
C2H95_18980	COG2814	Major facilitator Superfamily
C2H95_18985	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2H95_18990	COG3011	Protein conserved in bacteria
C2H95_19000	COG3290	protein histidine kinase activity
C2H95_19005	COG4565	transcriptional regulatory protein
C2H95_19010	COG1744	ABC transporter substrate-binding protein PnrA-like
C2H95_19015	COG3845	ABC transporter
C2H95_19020	COG4603	Belongs to the binding-protein-dependent transport system permease family
C2H95_19025	COG1079	Belongs to the binding-protein-dependent transport system permease family
C2H95_19030	COG3493	citrate carrier protein
C2H95_19040	COG2111	Na H antiporter
C2H95_19040	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2H95_19045	COG2111	Na H antiporter
C2H95_19050	COG1006	Multisubunit Na H antiporter MnhC subunit
C2H95_19055	COG0651	ATP synthesis coupled electron transport
C2H95_19060	COG1863	multisubunit Na H antiporter MnhE subunit
C2H95_19065	COG2212	antiporter activity
C2H95_19070	COG1320	monovalent cation:proton antiporter activity
C2H95_19075	COG2050	protein possibly involved in aromatic compounds catabolism
C2H95_19080	COG2197	response regulator
C2H95_19095	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C2H95_19100	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C2H95_19105	COG1335	isochorismatase
C2H95_19110	COG5506	Protein of unknown function (DUF1694)
C2H95_19125	COG0628	permease
C2H95_19140	COG1418	mRNA catabolic process
C2H95_19145	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_19155	COG1511	domain protein
C2H95_19160	COG0433	COG0433 Predicted ATPase
C2H95_19160	COG1674	ftsk spoiiie
C2H95_19165	COG4499	WXG100 protein secretion system (Wss), protein YukC
C2H95_19170	COG5417	Belongs to the EsaB family
C2H95_19175	COG4842	Belongs to the WXG100 family
C2H95_19180	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C2H95_19180	COG2508	Transcriptional regulator
C2H95_19185	COG0686	Belongs to the AlaDH PNT family
C2H95_19190	COG5634	Uncharacterized conserved protein (DUF2278)
C2H95_19195	COG3251	PFAM MbtH domain protein
C2H95_19200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H95_19205	COG1535	isochorismatase
C2H95_19205	COG3433	isochorismatase activity
C2H95_19210	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2H95_19215	COG1169	isochorismate synthase
C2H95_19220	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_19225	COG2819	hydrolase of the alpha beta superfamily
C2H95_19230	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2H95_19235	COG1268	BioY protein
C2H95_19240	COG2056	Na+-H+ antiporter family
C2H95_19245	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2H95_19250	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
C2H95_19255	COG3584	3D domain protein
C2H95_19270	COG1252	NADH dehydrogenase
C2H95_19275	COG0492	ferredoxin-NADP+ reductase activity
C2H95_19285	COG0516	GMP reductase activity
C2H95_19290	COG2808	Putative FMN-binding domain
C2H95_19295	COG0456	acetyltransferase
C2H95_19300	COG0316	Belongs to the HesB IscA family
C2H95_19305	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C2H95_19310	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2H95_19315	COG4844	belongs to the
C2H95_19320	COG1252	NADH dehydrogenase
C2H95_19325	COG4837	Protein of unknown function (DUF1462)
C2H95_19330	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C2H95_19335	COG1506	peptidase
C2H95_19335	COG0823	Involved in the tonB-independent uptake of proteins
C2H95_19335	COG4946	Tricorn protease homolog
C2H95_19340	COG0083	homoserine kinase activity
C2H95_19345	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2H95_19350	COG0460	homoserine dehydrogenase
C2H95_19355	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H95_19360	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2H95_19365	COG0647	UMP catabolic process
C2H95_19370	COG2445	Protein of unknown function DUF86
C2H95_19375	COG4470	Protein conserved in bacteria
C2H95_19385	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2H95_19390	COG0739	heme binding
C2H95_19400	COG3377	Domain of unknown function (DUF1805)
C2H95_19405	COG0737	Belongs to the 5'-nucleotidase family
C2H95_19410	COG0730	response to heat
C2H95_19415	COG1801	Protein of unknown function DUF72
C2H95_19425	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2H95_19430	COG2508	Transcriptional regulator
C2H95_19435	COG2233	PERMEase
C2H95_19440	COG2233	PERMEase
C2H95_19445	COG3648	Uricase
C2H95_19445	COG3195	allantoin biosynthetic process
C2H95_19450	COG2351	hydroxyisourate hydrolase activity
C2H95_19460	COG2080	2 iron, 2 sulfur cluster binding
C2H95_19465	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2H95_19470	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C2H95_19475	COG2068	MobA-Related Protein
C2H95_19480	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C2H95_19485	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2H95_19490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2H95_19495	COG2356	endonuclease I
C2H95_19500	COG3842	ATPase activity
C2H95_19505	COG2188	Transcriptional regulator
C2H95_19510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H95_19515	COG0395	ABC-type sugar transport system, permease component
C2H95_19520	COG1175	transmembrane transport
C2H95_19525	COG1653	transport
C2H95_19530	COG2222	sugar isomerase
C2H95_19535	COG0322	excinuclease ABC activity
C2H95_19540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2H95_19555	COG0346	lactoylglutathione lyase activity
C2H95_19560	COG0640	Transcriptional regulator
C2H95_19565	COG0719	Fe-S assembly protein
C2H95_19570	COG0822	iron-sulfur transferase activity
C2H95_19575	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2H95_19580	COG0719	Fe-S assembly protein
C2H95_19585	COG0396	ATPase activity
C2H95_19600	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2H95_19605	COG1464	Belongs to the NlpA lipoprotein family
C2H95_19610	COG2011	ABC-type metal ion transport system permease component
C2H95_19615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2H95_19625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H95_19630	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C2H95_19640	COG0509	glycine decarboxylation via glycine cleavage system
C2H95_19645	COG1393	Belongs to the ArsC family
C2H95_19650	COG1960	acyl-CoA dehydrogenase activity
C2H95_19655	COG0183	Belongs to the thiolase family
C2H95_19660	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2H95_19660	COG1024	Enoyl-CoA hydratase
C2H95_19670	COG0506	proline dehydrogenase activity
C2H95_19680	COG5577	PFAM Coat F domain
C2H95_19685	COG1846	Transcriptional regulator
C2H95_19690	COG0477	Major facilitator Superfamily
C2H95_19695	COG1942	4-Oxalocrotonate Tautomerase
C2H95_19700	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_19705	COG0583	DNA-binding transcription factor activity
C2H95_19715	COG1120	ATPase activity
C2H95_19730	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_19735	COG0783	Belongs to the Dps family
C2H95_19740	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H95_19745	COG0745	RESPONSE REGULATOR receiver
C2H95_19750	COG2205	protein histidine kinase activity
C2H95_19750	COG2770	Histidine kinase
C2H95_19760	COG1309	transcriptional regulator
C2H95_19765	COG0114	fumarate hydratase activity
C2H95_19775	COG0697	spore germination
C2H95_19780	COG0814	amino acid
C2H95_19790	COG2197	response regulator
C2H95_19795	COG4585	Histidine kinase
C2H95_19800	COG4758	membrane
C2H95_19805	COG3595	metallopeptidase activity
C2H95_19810	COG1842	Phage shock protein A
C2H95_19815	COG4758	membrane
C2H95_19820	COG2814	Major facilitator Superfamily
C2H95_19825	COG2096	Adenosyltransferase
C2H95_19830	COG1120	ATPase activity
C2H95_19835	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H95_19840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H95_19845	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_19850	COG3386	PFAM SMP-30 Gluconolaconase
C2H95_19855	COG2205	protein histidine kinase activity
C2H95_19860	COG0745	RESPONSE REGULATOR receiver
C2H95_19875	COG1191	sigma factor activity
C2H95_19885	COG2140	Oxalate decarboxylase
C2H95_19895	COG0577	efflux transmembrane transporter activity
C2H95_19900	COG1136	(ABC) transporter
C2H95_19905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2H95_19910	COG1120	ATPase activity
C2H95_19915	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H95_19920	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H95_19925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H95_19935	COG0531	amino acid
C2H95_19950	COG1988	membrane-bound metal-dependent
C2H95_19955	COG1368	sulfuric ester hydrolase activity
C2H95_19960	COG1910	domain protein
C2H95_19965	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2H95_19970	COG4149	molybdate abc transporter
C2H95_19975	COG0656	L-ascorbic acid biosynthetic process
C2H95_19985	COG0025	NhaP-type Na H and K H
C2H95_19990	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2H95_19995	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2H95_20000	COG3973	AAA domain
C2H95_20010	COG2860	membrane
C2H95_20015	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C2H95_20020	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2H95_20025	COG2217	Heavy metal translocating P-type atpase
C2H95_20030	COG2217	Heavy metal translocating P-type atpase
C2H95_20035	COG2608	mercury ion transmembrane transporter activity
C2H95_20040	COG1937	Protein conserved in bacteria
C2H95_20045	COG0673	inositol 2-dehydrogenase activity
C2H95_20050	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2H95_20055	COG1289	transmembrane transporter activity
C2H95_20065	COG2076	Multidrug Resistance protein
C2H95_20070	COG1309	transcriptional regulator
C2H95_20075	COG1028	Short-chain dehydrogenase reductase Sdr
C2H95_20100	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C2H95_20105	COG0557	exoribonuclease II activity
C2H95_20110	COG1647	Serine aminopeptidase, S33
C2H95_20115	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2H95_20120	COG0596	Alpha beta hydrolase
C2H95_20125	COG1476	TRANSCRIPTIONal
C2H95_20130	COG1396	sequence-specific DNA binding
C2H95_20135	COG1396	sequence-specific DNA binding
C2H95_20140	COG1733	regulation of RNA biosynthetic process
C2H95_20145	COG0840	transmembrane signaling receptor activity
C2H95_20170	COG1131	(ABC) transporter
C2H95_20200	COG1174	glycine betaine transport
C2H95_20205	COG1732	Glycine betaine
C2H95_20210	COG1174	glycine betaine transport
C2H95_20215	COG1125	glycine betaine transport
C2H95_20215	COG0517	IMP dehydrogenase activity
C2H95_20220	COG1510	regulation of RNA biosynthetic process
C2H95_20225	COG1174	glycine betaine transport
C2H95_20230	COG1732	Glycine betaine
C2H95_20235	COG1174	glycine betaine transport
C2H95_20240	COG1125	glycine betaine transport
C2H95_20240	COG0517	IMP dehydrogenase activity
C2H95_20245	COG1510	regulation of RNA biosynthetic process
C2H95_20250	COG2095	MarC family integral membrane protein
C2H95_20260	COG3064	Membrane
C2H95_20265	COG4640	response to antibiotic
C2H95_20270	COG0456	acetyltransferase
C2H95_20310	COG0148	phosphopyruvate hydratase activity
C2H95_20315	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C2H95_20320	COG0149	triose-phosphate isomerase activity
C2H95_20325	COG0126	phosphoglycerate kinase activity
C2H95_20330	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2H95_20335	COG2390	Transcriptional regulator
C2H95_20340	COG2814	Major facilitator Superfamily
C2H95_20345	COG1609	Transcriptional regulator
C2H95_20350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H95_20360	COG0583	DNA-binding transcription factor activity
C2H95_20365	COG0697	spore germination
C2H95_20370	COG1113	amino acid transport
C2H95_20375	COG3858	chitin binding
C2H95_20380	COG1556	Lactate utilization protein
C2H95_20385	COG1139	Iron-sulfur cluster binding protein
C2H95_20390	COG0247	lactate metabolic process
C2H95_20395	COG2197	response regulator
C2H95_20400	COG4585	Histidine kinase
C2H95_20405	COG0842	Transport permease protein
C2H95_20410	COG1131	(ABC) transporter
C2H95_20415	COG0596	Alpha beta hydrolase
C2H95_20420	COG2208	phosphoserine phosphatase activity
C2H95_20425	COG3867	Arabinogalactan endo-beta-1,4-galactanase
C2H95_20430	COG1874	Beta-galactosidase
C2H95_20435	COG3833	ABC-type maltose transport systems, permease component
C2H95_20440	COG1175	transmembrane transport
C2H95_20445	COG2182	Extracellular solute-binding protein
C2H95_20450	COG1609	Transcriptional regulator
C2H95_20455	COG2186	Transcriptional regulator
C2H95_20460	COG1620	l-lactate permease
C2H95_20465	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2H95_20475	COG5039	Polysaccharide pyruvyl transferase
C2H95_20480	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2H95_20485	COG0110	maltose O-acetyltransferase activity
C2H95_20490	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2H95_20495	COG2244	polysaccharide biosynthetic process
C2H95_20500	COG1216	Glycosyl transferase, family 2
C2H95_20505	COG5039	Polysaccharide pyruvyl transferase
C2H95_20510	COG1216	Glycosyl transferase, family 2
C2H95_20520	COG0438	transferase activity, transferring glycosyl groups
C2H95_20525	COG1215	transferase activity, transferring glycosyl groups
C2H95_20530	COG0438	transferase activity, transferring glycosyl groups
C2H95_20535	COG1086	Polysaccharide biosynthesis protein
C2H95_20540	COG0489	protein tyrosine kinase activity
C2H95_20545	COG3944	biosynthesis protein
C2H95_20550	COG1396	sequence-specific DNA binding
C2H95_20555	COG2272	Belongs to the type-B carboxylesterase lipase family
C2H95_20565	COG3479	Phenolic acid decarboxylase
C2H95_20575	COG1794	racemase activity, acting on amino acids and derivatives
C2H95_20580	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2H95_20590	COG1621	beta-fructofuranosidase activity
C2H95_20595	COG1621	beta-fructofuranosidase activity
C2H95_20600	COG0531	amino acid
C2H95_20605	COG1309	transcriptional regulator
C2H95_20610	COG2076	Multidrug Resistance protein
C2H95_20615	COG2076	Multidrug Resistance protein
C2H95_20630	COG0740	serine-type endopeptidase activity
C2H95_20635	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2H95_20640	COG0366	Alpha amylase catalytic
C2H95_20645	COG1554	hydrolase, family 65, central catalytic
C2H95_20650	COG5521	maltodextrose utilization protein MalA
C2H95_20655	COG3833	ABC-type maltose transport systems, permease component
C2H95_20660	COG1175	transmembrane transport
C2H95_20665	COG2182	Extracellular solute-binding protein
C2H95_20670	COG0366	Alpha amylase catalytic
C2H95_20675	COG1609	Transcriptional regulator
C2H95_20680	COG1611	Belongs to the LOG family
C2H95_20685	COG1694	Mazg nucleotide pyrophosphohydrolase
C2H95_20690	COG0659	secondary active sulfate transmembrane transporter activity
C2H95_20695	COG0288	reversible hydration of carbon dioxide
C2H95_20700	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2H95_20705	COG0577	efflux transmembrane transporter activity
C2H95_20710	COG1136	(ABC) transporter
C2H95_20715	COG5002	protein histidine kinase activity
C2H95_20720	COG0745	RESPONSE REGULATOR receiver
C2H95_20730	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C2H95_20735	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H95_20740	COG1481	regulation of sporulation
C2H95_20745	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C2H95_20750	COG1660	Displays ATPase and GTPase activities
C2H95_20755	COG1051	belongs to the nudix hydrolase family
C2H95_20760	COG0492	ferredoxin-NADP+ reductase activity
C2H95_20765	COG0791	NLP P60 protein
C2H95_20765	COG3883	PFAM NLP P60 protein
C2H95_20770	COG0457	Tetratricopeptide repeat
C2H95_20775	COG1132	(ABC) transporter
C2H95_20795	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2H95_20795	COG0140	phosphoribosyl-ATP diphosphatase activity
C2H95_20800	COG0107	imidazoleglycerol-phosphate synthase activity
C2H95_20805	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C2H95_20810	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2H95_20815	COG0131	Imidazoleglycerol-phosphate dehydratase
C2H95_20820	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C2H95_20825	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C2H95_20830	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C2H95_20835	COG4990	cell redox homeostasis
C2H95_20840	COG5297	Belongs to the glycosyl hydrolase family 6
C2H95_20845	COG0110	maltose O-acetyltransferase activity
C2H95_20850	COG0546	phosphoglycolate phosphatase activity
C2H95_20855	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C2H95_20860	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C2H95_20865	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C2H95_20870	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2H95_20875	COG0363	glucosamine-6-phosphate deaminase activity
C2H95_20880	COG2188	Transcriptional regulator
C2H95_20885	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2H95_20890	COG1846	Transcriptional regulator
C2H95_20895	COG2124	cytochrome p450
C2H95_20905	COG1846	Transcriptional regulator
C2H95_20910	COG2814	Major facilitator Superfamily
C2H95_20915	COG1950	PFAM Membrane protein of
C2H95_20920	COG1983	PspC domain protein
C2H95_20925	COG3595	metallopeptidase activity
C2H95_20940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2H95_20945	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2H95_20950	COG0556	nucleotide-excision repair
C2H95_20955	COG4897	Protein conserved in bacteria