locus-tag	class	description
C2H94_00010	COG0346	lactoylglutathione lyase activity
C2H94_00020	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H94_00025	COG0793	Belongs to the peptidase S41A family
C2H94_00025	COG3409	Peptidoglycan-binding domain 1 protein
C2H94_00030	COG2226	methyltransferase
C2H94_00040	COG1876	peptidase activity
C2H94_00045	COG0813	purine-nucleoside phosphorylase activity
C2H94_00060	COG0671	phosphoesterase, PA-phosphatase related
C2H94_00085	COG4479	Belongs to the UPF0346 family
C2H94_00095	COG1509	lysine 2,3-aminomutase activity
C2H94_00100	COG0456	acetyltransferase
C2H94_00105	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2H94_00110	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2H94_00115	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2H94_00120	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2H94_00130	COG0456	acetyltransferase
C2H94_00135	COG0463	Glycosyl transferase, family 2
C2H94_00150	COG4641	Protein conserved in bacteria
C2H94_00155	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
C2H94_00160	COG1086	Polysaccharide biosynthesis protein
C2H94_00165	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2H94_00170	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2H94_00175	COG1846	Transcriptional regulator
C2H94_00180	COG0534	Mate efflux family protein
C2H94_00190	COG4698	Protein conserved in bacteria
C2H94_00195	COG2755	lipolytic protein G-D-S-L family
C2H94_00200	COG1999	signal sequence binding
C2H94_00215	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2H94_00220	COG1272	protein, Hemolysin III
C2H94_00225	COG0204	Acyl-transferase
C2H94_00230	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2H94_00235	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2H94_00245	COG2136	Putative SAM-dependent methyltransferase
C2H94_00245	COG2521	methyltransferase
C2H94_00255	COG0129	dihydroxy-acid dehydratase activity
C2H94_00260	COG1413	lyase activity
C2H94_00265	COG1418	mRNA catabolic process
C2H94_00270	COG0386	Belongs to the glutathione peroxidase family
C2H94_00275	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C2H94_00280	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2H94_00285	COG1278	Cold shock
C2H94_00305	COG0328	RNA-DNA hybrid ribonuclease activity
C2H94_00310	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2H94_00315	COG0328	RNA-DNA hybrid ribonuclease activity
C2H94_00325	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2H94_00340	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2H94_00350	COG1755	Isoprenylcysteine carboxyl methyltransferase
C2H94_00355	COG3424	synthase
C2H94_00360	COG2233	PERMEase
C2H94_00365	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2H94_00370	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C2H94_00380	COG0800	Aldolase
C2H94_00385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H94_00395	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C2H94_00400	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_00405	COG1199	ATP-dependent helicase activity
C2H94_00420	COG0116	Belongs to the methyltransferase superfamily
C2H94_00435	COG4474	Belongs to the UPF0398 family
C2H94_00445	COG3359	exonuclease
C2H94_00450	COG1205	dead DEAH box helicase
C2H94_00450	COG1111	helicase
C2H94_00455	COG2190	(PTS) system
C2H94_00460	COG0071	Belongs to the small heat shock protein (HSP20) family
C2H94_00495	COG3331	DNA recombination
C2H94_00500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2H94_00500	COG4499	WXG100 protein secretion system (Wss), protein YukC
C2H94_00510	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2H94_00515	COG3935	DnaD domain protein
C2H94_00520	COG0017	Asparaginyl-tRNA synthetase
C2H94_00525	COG0436	Aminotransferase
C2H94_00530	COG5353	protein conserved in bacteria
C2H94_00540	COG1199	ATP-dependent helicase activity
C2H94_00540	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2H94_00545	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C2H94_00550	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C2H94_00555	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C2H94_00560	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C2H94_00560	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C2H94_00565	COG0617	tRNA 3'-terminal CCA addition
C2H94_00570	COG0438	transferase activity, transferring glycosyl groups
C2H94_00575	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2H94_00580	COG1803	Methylglyoxal synthase
C2H94_00585	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C2H94_00590	COG1694	Mazg nucleotide pyrophosphohydrolase
C2H94_00595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H94_00605	COG4347	Protein of unknown function (DUF1405)
C2H94_00610	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2H94_00610	COG2010	Cytochrome c
C2H94_00615	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2H94_00620	COG0723	plastoquinol--plastocyanin reductase activity
C2H94_00630	COG5582	Belongs to the UPF0302 family
C2H94_00635	COG0457	Tetratricopeptide repeat
C2H94_00640	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C2H94_00645	COG0287	Prephenate dehydrogenase
C2H94_00655	COG0159	tryptophan synthase activity
C2H94_00660	COG0133	tryptophan synthase activity
C2H94_00665	COG0135	phosphoribosylanthranilate isomerase activity
C2H94_00675	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2H94_00680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2H94_00685	COG4401	Chorismate mutase type I
C2H94_00690	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C2H94_00695	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C2H94_00700	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2H94_00705	COG0105	UTP biosynthetic process
C2H94_00710	COG0142	geranyltranstransferase activity
C2H94_00715	COG2226	methyltransferase
C2H94_00720	COG0142	geranyltranstransferase activity
C2H94_00730	COG0302	gtp cyclohydrolase
C2H94_00735	COG0776	regulation of translation
C2H94_00740	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2H94_00755	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C2H94_00760	COG1160	GTP binding
C2H94_00785	COG1304	FMN binding
C2H94_00790	COG0539	negative regulation of cytoplasmic translation
C2H94_00795	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C2H94_00805	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C2H94_00810	COG2959	enzyme of heme biosynthesis
C2H94_00815	COG3409	Peptidoglycan-binding domain 1 protein
C2H94_00815	COG3773	Cell wall hydrolase
C2H94_00820	COG2339	peptidase activity
C2H94_00825	COG0492	ferredoxin-NADP+ reductase activity
C2H94_00830	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2H94_00835	COG4862	establishment of competence for transformation
C2H94_00840	COG1408	metallophosphoesterase
C2H94_00855	COG1266	CAAX protease self-immunity
C2H94_00860	COG0514	ATP-dependent DNA helicase (RecQ)
C2H94_00865	COG4955	Helix-turn-helix domain
C2H94_00870	COG1141	Ferredoxin
C2H94_00875	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C2H94_00880	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2H94_00885	COG0710	3-dehydroquinate dehydratase activity
C2H94_00895	COG1595	DNA-templated transcription, initiation
C2H94_00900	COG5002	protein histidine kinase activity
C2H94_00905	COG0745	RESPONSE REGULATOR receiver
C2H94_00910	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2H94_00915	COG1333	cytochrome c biogenesis protein
C2H94_00920	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H94_00925	COG1187	pseudouridine synthase activity
C2H94_00930	COG0700	Nucleoside recognition
C2H94_00935	COG2715	membrane protein required for spore maturation
C2H94_00940	COG1686	Belongs to the peptidase S11 family
C2H94_00950	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C2H94_00955	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C2H94_00960	COG1547	Domain of unknown function (DUF309)
C2H94_00965	COG0456	acetyltransferase
C2H94_00970	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C2H94_00975	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2H94_00975	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2H94_00980	COG0307	riboflavin synthase, alpha
C2H94_00985	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2H94_00985	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2H94_00995	COG0681	Belongs to the peptidase S26 family
C2H94_01005	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
C2H94_01015	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2H94_01025	COG4086	secreted protein
C2H94_01030	COG0019	diaminopimelate decarboxylase activity
C2H94_01035	COG0697	spore germination
C2H94_01070	COG1191	sigma factor activity
C2H94_01075	COG2172	sigma factor antagonist activity
C2H94_01080	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H94_01085	COG1686	Belongs to the peptidase S11 family
C2H94_01090	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C2H94_01095	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C2H94_01100	COG4974	Belongs to the 'phage' integrase family
C2H94_01110	COG0735	belongs to the Fur family
C2H94_01115	COG1300	Membrane
C2H94_01125	COG0281	malic enzyme
C2H94_01130	COG1757	Na H antiporter
C2H94_01135	COG1027	Aspartate ammonia-lyase
C2H94_01140	COG0252	asparaginase activity
C2H94_01145	COG1396	sequence-specific DNA binding
C2H94_01150	COG1379	DNA repair
C2H94_01155	COG0494	nUDIX hydrolase
C2H94_01165	COG0667	Aldo Keto reductase
C2H94_01175	COG1073	alpha beta
C2H94_01185	COG4918	Iron-sulphur cluster biosynthesis
C2H94_01190	COG0456	acetyltransferase
C2H94_01190	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2H94_01195	COG2329	Antibiotic biosynthesis monooxygenase
C2H94_01200	COG0456	acetyltransferase
C2H94_01210	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2H94_01220	COG2211	Major facilitator Superfamily
C2H94_01230	COG0346	lactoylglutathione lyase activity
C2H94_01235	COG1072	(Pantothenic acid kinase))
C2H94_01240	COG3048	D-serine ammonia-lyase activity
C2H94_01245	COG0300	oxidoreductase activity
C2H94_01250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H94_01255	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2H94_01260	COG4187	Peptidase family M20/M25/M40
C2H94_01265	COG1902	pentaerythritol trinitrate reductase activity
C2H94_01270	COG0596	Alpha beta hydrolase
C2H94_01280	COG1234	tRNA 3'-trailer cleavage
C2H94_01285	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2H94_01290	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C2H94_01295	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2H94_01305	COG0706	membrane insertase activity
C2H94_01310	COG3361	conserved protein (COG2071)
C2H94_01315	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2H94_01320	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2H94_01325	COG0346	lactoylglutathione lyase activity
C2H94_01330	COG1376	ErfK ybiS ycfS ynhG family protein
C2H94_01335	COG4129	membrane
C2H94_01340	COG1126	abc transporter atp-binding protein
C2H94_01345	COG0765	amino acid transport
C2H94_01350	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H94_01360	COG1597	lipid kinase activity
C2H94_01365	COG2814	Major facilitator Superfamily
C2H94_01370	COG4978	Transcriptional regulator
C2H94_01370	COG0789	Transcriptional regulator
C2H94_01375	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H94_01380	COG0022	dehydrogenase e1 component
C2H94_01385	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2H94_01390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2H94_01395	COG3426	butyrate kinase activity
C2H94_01400	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2H94_01405	COG0280	phosphate acetyltransferase
C2H94_01410	COG3290	protein histidine kinase activity
C2H94_01410	COG3829	transcription factor binding
C2H94_01420	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C2H94_01425	COG2079	MmgE PrpD family protein
C2H94_01430	COG0372	Belongs to the citrate synthase family
C2H94_01435	COG1960	acyl-CoA dehydrogenase activity
C2H94_01440	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2H94_01445	COG0183	Belongs to the thiolase family
C2H94_01450	COG0584	glycerophosphoryl diester phosphodiesterase
C2H94_01455	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H94_01465	COG1902	pentaerythritol trinitrate reductase activity
C2H94_01470	COG0745	RESPONSE REGULATOR receiver
C2H94_01475	COG0750	zinc metalloprotease
C2H94_01480	COG0497	DNA recombination
C2H94_01485	COG1438	arginine binding
C2H94_01490	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C2H94_01495	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2H94_01500	COG0142	geranyltranstransferase activity
C2H94_01505	COG1722	exodeoxyribonuclease VII activity
C2H94_01510	COG1570	exodeoxyribonuclease VII activity
C2H94_01515	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C2H94_01520	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2H94_01525	COG1302	Protein conserved in bacteria
C2H94_01530	COG0439	Biotin carboxylase
C2H94_01535	COG0511	ligase activity, forming carbon-carbon bonds
C2H94_01575	COG3854	ATPases associated with a variety of cellular activities
C2H94_01585	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C2H94_01590	COG0006	proline dipeptidase activity
C2H94_01595	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C2H94_01605	COG3872	metal-dependent enzyme
C2H94_01615	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2H94_01620	COG1321	iron dependent repressor
C2H94_01625	COG0095	Lipoate-protein ligase
C2H94_01630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2H94_01635	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2H94_01640	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2H94_01645	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2H94_01650	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2H94_01670	COG1396	sequence-specific DNA binding
C2H94_01680	COG0681	Belongs to the peptidase S26 family
C2H94_01705	COG4940	Competence protein ComGF
C2H94_01715	COG4970	Tfp pilus assembly protein FimT
C2H94_01720	COG4537	Required for transformation and DNA binding
C2H94_01725	COG1459	type II secretion system
C2H94_01730	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2H94_01735	COG0517	IMP dehydrogenase activity
C2H94_01740	COG0598	Magnesium transport protein CorA
C2H94_01745	COG1253	flavin adenine dinucleotide binding
C2H94_01750	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H94_01760	COG1393	Belongs to the ArsC family
C2H94_01770	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H94_01780	COG0011	TIGRFAM Protein of
C2H94_01790	COG2866	Carboxypeptidase
C2H94_01795	COG1368	sulfuric ester hydrolase activity
C2H94_01800	COG1940	carbohydrate kinase activity
C2H94_01805	COG4483	Protein conserved in bacteria
C2H94_01810	COG0457	Tetratricopeptide repeat
C2H94_01810	COG0705	Rhomboid family
C2H94_01820	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2H94_01830	COG0438	transferase activity, transferring glycosyl groups
C2H94_01845	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2H94_01850	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2H94_01855	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2H94_01860	COG0581	inorganic phosphate transmembrane transporter activity
C2H94_01865	COG0573	inorganic phosphate transmembrane transporter activity
C2H94_01870	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2H94_01875	COG0768	penicillin binding
C2H94_01880	COG0477	Major facilitator Superfamily
C2H94_01885	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2H94_01890	COG2839	Protein conserved in bacteria
C2H94_01895	COG5521	maltodextrose utilization protein MalA
C2H94_01900	COG1388	LysM domain
C2H94_01905	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C2H94_01910	COG4709	membrane
C2H94_01915	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
C2H94_01920	COG0735	belongs to the Fur family
C2H94_01925	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H94_01935	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C2H94_01940	COG0513	Belongs to the DEAD box helicase family
C2H94_01950	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C2H94_01955	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2H94_01960	COG2384	SAM-dependent methyltransferase
C2H94_01965	COG2010	Cytochrome c
C2H94_01975	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2H94_01980	COG0358	DNA primase activity
C2H94_01985	COG1671	Belongs to the UPF0178 family
C2H94_01990	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C2H94_01995	COG0517	IMP dehydrogenase activity
C2H94_02000	COG0751	glycine-tRNA ligase activity
C2H94_02005	COG0752	glycyl-tRNA synthetase alpha subunit
C2H94_02010	COG1381	Involved in DNA repair and RecF pathway recombination
C2H94_02020	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C2H94_02025	COG0295	cytidine deaminase activity
C2H94_02030	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2H94_02035	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C2H94_02040	COG1480	7TM receptor with intracellular HD hydrolase
C2H94_02045	COG1702	phosphate starvation-inducible protein PhoH
C2H94_02050	COG0561	phosphatase activity
C2H94_02065	COG4864	UPF0365 protein
C2H94_02075	COG1610	YqeY-like protein
C2H94_02085	COG1283	sodium-dependent phosphate transmembrane transporter activity
C2H94_02090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2H94_02095	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2H94_02100	COG2264	protein methyltransferase activity
C2H94_02105	COG0484	heat shock protein binding
C2H94_02115	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C2H94_02120	COG1420	regulation of RNA biosynthetic process
C2H94_02125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2H94_02130	COG0481	GTPase activity
C2H94_02140	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H94_02145	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C2H94_02150	COG0268	Binds directly to 16S ribosomal RNA
C2H94_02155	COG1466	dna polymerase III delta subunit
C2H94_02165	COG0658	competence protein
C2H94_02165	COG2333	competence protein COMEC
C2H94_02170	COG2131	deaminase
C2H94_02175	COG1555	photosystem II stabilization
C2H94_02175	COG1596	polysaccharide export
C2H94_02180	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2H94_02185	COG2226	methyltransferase
C2H94_02190	COG0799	negative regulation of ribosome biogenesis
C2H94_02195	COG1713	HD superfamily hydrolase involved in NAD metabolism
C2H94_02200	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2H94_02205	COG1534	Rna-binding protein
C2H94_02210	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2H94_02215	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2H94_02220	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C2H94_02230	COG2755	lipolytic protein G-D-S-L family
C2H94_02235	COG3409	Peptidoglycan-binding domain 1 protein
C2H94_02235	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2H94_02240	COG0398	Pfam SNARE associated Golgi protein
C2H94_02245	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C2H94_02255	COG3209	COG3209 Rhs family protein
C2H94_02270	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2H94_02290	COG0457	Tetratricopeptide repeat
C2H94_02305	COG5444	nuclease activity
C2H94_02315	COG2732	(Barnase) inhibitor
C2H94_02330	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2H94_02330	COG3409	Peptidoglycan-binding domain 1 protein
C2H94_02345	COG5484	DNA packaging
C2H94_02370	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C2H94_02380	COG1484	DNA-dependent DNA replication
C2H94_02385	COG3935	DnaD domain protein
C2H94_02390	COG3723	Recombinational DNA repair protein, rece pathway
C2H94_02395	COG5377	YqaJ viral recombinase family
C2H94_02420	COG1476	TRANSCRIPTIONal
C2H94_02425	COG3620	sequence-specific DNA binding
C2H94_02440	COG2856	Zn peptidase
C2H94_02450	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2H94_02460	COG3223	Belongs to the PsiE family
C2H94_02465	COG0642	Histidine kinase
C2H94_02465	COG5002	protein histidine kinase activity
C2H94_02470	COG0745	RESPONSE REGULATOR receiver
C2H94_02475	COG2311	Membrane
C2H94_02480	COG0454	-acetyltransferase
C2H94_02485	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2H94_02495	COG0730	response to heat
C2H94_02500	COG0425	Belongs to the sulfur carrier protein TusA family
C2H94_02505	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H94_02505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2H94_02515	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2H94_02515	COG0425	Belongs to the sulfur carrier protein TusA family
C2H94_02525	COG2210	Belongs to the sulfur carrier protein TusA family
C2H94_02530	COG1937	Protein conserved in bacteria
C2H94_02545	COG0662	Cupin 2, conserved barrel domain protein
C2H94_02565	COG0789	Transcriptional regulator
C2H94_02565	COG4978	Transcriptional regulator
C2H94_02570	COG2814	Major facilitator Superfamily
C2H94_02575	COG0456	acetyltransferase
C2H94_02580	COG1253	flavin adenine dinucleotide binding
C2H94_02590	COG0697	spore germination
C2H94_02595	COG0583	DNA-binding transcription factor activity
C2H94_02600	COG2072	flavoprotein involved in K transport
C2H94_02605	COG1230	cation diffusion facilitator family transporter
C2H94_02615	COG1114	Component of the transport system for branched-chain amino acids
C2H94_02620	COG1687	branched-chain amino acid
C2H94_02630	COG1522	sequence-specific DNA binding
C2H94_02635	COG2732	(Barnase) inhibitor
C2H94_02640	COG2124	cytochrome p450
C2H94_02655	COG1335	isochorismatase
C2H94_02670	COG2318	DinB family
C2H94_02680	COG2070	2-Nitropropane dioxygenase
C2H94_02695	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2H94_02710	COG3443	Belongs to the bacterial solute-binding protein 9 family
C2H94_02715	COG1595	DNA-templated transcription, initiation
C2H94_02720	COG0667	Aldo Keto reductase
C2H94_02725	COG2851	Citrate transporter
C2H94_02730	COG0583	DNA-binding transcription factor activity
C2H94_02735	COG2828	Protein conserved in bacteria
C2H94_02740	COG3409	Peptidoglycan-binding domain 1 protein
C2H94_02745	COG5566	PFAM Mor transcription activator
C2H94_02750	COG0596	Alpha beta hydrolase
C2H94_02755	COG4991	sh3 domain protein
C2H94_02760	COG4991	sh3 domain protein
C2H94_02765	COG0346	lactoylglutathione lyase activity
C2H94_02775	COG5577	PFAM Coat F domain
C2H94_02780	COG1063	alcohol dehydrogenase
C2H94_02790	COG5577	PFAM Coat F domain
C2H94_02795	COG0789	Transcriptional regulator
C2H94_02805	COG1064	alcohol dehydrogenase
C2H94_02810	COG0693	protein deglycase activity
C2H94_02815	COG1621	beta-fructofuranosidase activity
C2H94_02820	COG3716	PTS system mannose fructose sorbose family IID component
C2H94_02825	COG3715	PTS system
C2H94_02830	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H94_02835	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H94_02840	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2H94_02840	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C2H94_02845	COG1113	amino acid transport
C2H94_02850	COG1280	lysine exporter protein (LysE YggA)
C2H94_02855	COG1378	Sugar-specific transcriptional regulator TrmB
C2H94_02860	COG1595	DNA-templated transcription, initiation
C2H94_02870	COG2755	lipolytic protein G-D-S-L family
C2H94_02870	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C2H94_02880	COG2124	cytochrome p450
C2H94_02880	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2H94_02885	COG1309	transcriptional regulator
C2H94_02890	COG2226	methyltransferase
C2H94_02900	COG2116	formate transmembrane transporter activity
C2H94_02905	COG5609	conserved protein (DUF2294)
C2H94_02910	COG3383	formate dehydrogenase (NAD+) activity
C2H94_02915	COG2427	Protein of unknown function (DUF1641)
C2H94_02925	COG0626	cystathionine gamma-synthase activity
C2H94_02930	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2H94_02935	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2H94_02940	COG2226	methyltransferase
C2H94_02955	COG0768	penicillin binding
C2H94_02960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2H94_02965	COG0572	uridine kinase
C2H94_02970	COG0826	peptidase U32
C2H94_02975	COG0826	peptidase U32
C2H94_02980	COG4122	O-methyltransferase activity
C2H94_02985	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2H94_02990	COG3906	Belongs to the UPF0473 family
C2H94_02995	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C2H94_03000	COG4472	Bacterial protein of unknown function (DUF965)
C2H94_03005	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2H94_03010	COG0628	permease
C2H94_03015	COG1126	abc transporter atp-binding protein
C2H94_03020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H94_03025	COG0765	amino acid transport
C2H94_03030	COG0765	amino acid transport
C2H94_03045	COG3881	PFAM PRC-barrel domain
C2H94_03050	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2H94_03055	COG0457	Tetratricopeptide repeat
C2H94_03060	COG0482	sulfurtransferase activity
C2H94_03065	COG1104	cysteine desulfurase activity
C2H94_03070	COG1959	2 iron, 2 sulfur cluster binding
C2H94_03075	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2H94_03080	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2H94_03090	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C2H94_03095	COG0124	histidyl-tRNA synthetase
C2H94_03105	COG4991	sh3 domain protein
C2H94_03105	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H94_03105	COG3103	Sh3 type 3 domain protein
C2H94_03110	COG1490	D-aminoacyl-tRNA deacylase activity
C2H94_03115	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2H94_03120	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2H94_03125	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2H94_03125	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C2H94_03130	COG5416	Lipopolysaccharide assembly protein A domain
C2H94_03135	COG0490	domain, Protein
C2H94_03140	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2H94_03140	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2H94_03150	COG2244	polysaccharide biosynthetic process
C2H94_03155	COG2323	membrane
C2H94_03165	COG1862	Preprotein translocase
C2H94_03170	COG0343	queuine tRNA-ribosyltransferase activity
C2H94_03175	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C2H94_03185	COG2255	four-way junction helicase activity
C2H94_03190	COG0632	four-way junction helicase activity
C2H94_03200	COG2814	Major facilitator Superfamily
C2H94_03205	COG0673	inositol 2-dehydrogenase activity
C2H94_03210	COG2112	serine threonine protein kinase
C2H94_03225	COG1115	amino acid carrier protein
C2H94_03230	COG0217	transcriptional regulatory protein
C2H94_03240	COG1388	LysM domain
C2H94_03245	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2H94_03250	COG0157	Belongs to the NadC ModD family
C2H94_03255	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2H94_03260	COG1104	cysteine desulfurase activity
C2H94_03265	COG1827	regulation of RNA biosynthetic process
C2H94_03270	COG0077	Prephenate dehydratase
C2H94_03275	COG4492	Belongs to the UPF0735 family
C2H94_03280	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C2H94_03285	COG3290	protein histidine kinase activity
C2H94_03290	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C2H94_03295	COG2868	ribosomal protein
C2H94_03300	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C2H94_03305	COG1994	Peptidase M50
C2H94_03310	COG0739	heme binding
C2H94_03315	COG2894	cell division
C2H94_03320	COG0850	regulation of cytokinetic process
C2H94_03325	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2H94_03335	COG1077	Cell shape determining protein MreB Mrl
C2H94_03340	COG2003	Belongs to the UPF0758 family
C2H94_03345	COG0424	maF-like protein
C2H94_03355	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C2H94_03360	COG0285	dihydrofolate synthase activity
C2H94_03365	COG0525	valine-tRNA ligase activity
C2H94_03375	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H94_03380	COG1388	LysM domain
C2H94_03385	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2H94_03390	COG0113	porphobilinogen synthase activity
C2H94_03395	COG1587	Uroporphyrinogen-III synthase
C2H94_03400	COG0181	hydroxymethylbilane synthase activity
C2H94_03405	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2H94_03410	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C2H94_03420	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C2H94_03425	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2H94_03430	COG1067	ATP-dependent peptidase activity
C2H94_03430	COG0470	DNA polymerase III
C2H94_03435	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C2H94_03440	COG0544	peptidyl-prolyl cis-trans isomerase activity
C2H94_03445	COG0457	Tetratricopeptide repeat
C2H94_03445	COG1477	protein flavinylation
C2H94_03450	COG0066	3-isopropylmalate dehydratase activity
C2H94_03455	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2H94_03460	COG0473	3-isopropylmalate dehydrogenase activity
C2H94_03465	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2H94_03470	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C2H94_03475	COG0440	acetolactate synthase activity
C2H94_03480	COG0028	Belongs to the TPP enzyme family
C2H94_03490	COG0454	-acetyltransferase
C2H94_03500	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
C2H94_03510	COG0622	Phosphoesterase
C2H94_03515	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C2H94_03520	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C2H94_03525	COG5401	PFAM Sporulation and spore germination
C2H94_03530	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2H94_03535	COG1846	Transcriptional regulator
C2H94_03540	COG2197	response regulator
C2H94_03545	COG0824	Thioesterase
C2H94_03550	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2H94_03555	COG1053	succinate dehydrogenase
C2H94_03560	COG2009	succinate dehydrogenase
C2H94_03565	COG1719	4-vinyl reductase, 4VR
C2H94_03570	COG0527	aspartate kinase activity
C2H94_03580	COG0322	excinuclease ABC activity
C2H94_03585	COG3118	belongs to the thioredoxin family
C2H94_03595	COG3534	alpha-L-arabinofuranosidase
C2H94_03600	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C2H94_03605	COG2086	electron transfer activity
C2H94_03610	COG1024	Enoyl-CoA hydratase
C2H94_03615	COG1309	transcriptional regulator
C2H94_03620	COG0318	PFAM AMP-dependent synthetase and ligase
C2H94_03625	COG3766	membrane
C2H94_03630	COG1193	negative regulation of DNA recombination
C2H94_03635	COG1796	DNA polymerase
C2H94_03635	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2H94_03640	COG1286	toxin biosynthetic process
C2H94_03645	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C2H94_03650	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2H94_03655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H94_03655	COG0072	phenylalanine-tRNA ligase activity
C2H94_03660	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C2H94_03670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2H94_03680	COG3835	regulator
C2H94_03685	COG0277	FAD linked oxidase domain protein
C2H94_03690	COG0247	lactate metabolic process
C2H94_03695	COG0346	lactoylglutathione lyase activity
C2H94_03705	COG1966	Carbon starvation protein
C2H94_03710	COG3534	alpha-L-arabinofuranosidase
C2H94_03715	COG0395	ABC-type sugar transport system, permease component
C2H94_03720	COG1175	transmembrane transport
C2H94_03725	COG1653	transport
C2H94_03730	COG0371	Dehydrogenase
C2H94_03735	COG0647	UMP catabolic process
C2H94_03740	COG0235	Class ii aldolase
C2H94_03745	COG1069	ribulokinase activity
C2H94_03750	COG2160	L-arabinose isomerase activity
C2H94_03755	COG3507	Belongs to the glycosyl hydrolase 43 family
C2H94_03760	COG1363	Peptidase, m42
C2H94_03770	COG3326	Membrane
C2H94_03775	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C2H94_03780	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C2H94_03785	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C2H94_03795	COG1346	cytolysis
C2H94_03800	COG1380	Effector of murein hydrolase LrgA
C2H94_03805	COG3279	Response regulator of the LytR AlgR family
C2H94_03810	COG3275	phosphorelay sensor kinase activity
C2H94_03815	COG1011	Hydrolase
C2H94_03820	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2H94_03830	COG0398	Pfam SNARE associated Golgi protein
C2H94_03835	COG1484	DNA-dependent DNA replication
C2H94_03840	COG3611	Membrane attachment protein
C2H94_03845	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C2H94_03850	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C2H94_03855	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2H94_03860	COG1733	regulation of RNA biosynthetic process
C2H94_03865	COG2814	Major facilitator Superfamily
C2H94_03870	COG0656	L-ascorbic acid biosynthetic process
C2H94_03875	COG0237	dephospho-CoA kinase activity
C2H94_03880	COG1971	Probably functions as a manganese efflux pump
C2H94_03885	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C2H94_03890	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2H94_03890	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2H94_03895	COG5002	protein histidine kinase activity
C2H94_03900	COG0745	RESPONSE REGULATOR receiver
C2H94_03910	COG0039	L-malate dehydrogenase activity
C2H94_03915	COG0538	isocitrate dehydrogenase activity
C2H94_03920	COG0372	Belongs to the citrate synthase family
C2H94_03925	COG2707	UPF0756 membrane protein
C2H94_03930	COG0628	permease
C2H94_03935	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2H94_03940	COG0469	pyruvate kinase activity
C2H94_03945	COG0205	6-phosphofructokinase activity
C2H94_03950	COG0825	malonyl-CoA metabolic process
C2H94_03955	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C2H94_03960	COG0281	malic enzyme
C2H94_03965	COG0587	DNA-directed DNA polymerase activity
C2H94_03985	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C2H94_03995	COG4109	DRTGG domain
C2H94_04000	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2H94_04005	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_04015	COG0165	Argininosuccinate lyase
C2H94_04020	COG0137	argininosuccinate synthase activity
C2H94_04025	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2H94_04030	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2H94_04040	COG0827	DNA restriction-modification system
C2H94_04045	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C2H94_04050	COG3874	Sporulation protein YtfJ
C2H94_04060	COG1714	RDD family
C2H94_04065	COG0616	signal peptide processing
C2H94_04070	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2H94_04075	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C2H94_04080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2H94_04090	COG0301	tRNA thio-modification
C2H94_04095	COG1104	cysteine desulfurase activity
C2H94_04100	COG1114	Component of the transport system for branched-chain amino acids
C2H94_04105	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C2H94_04110	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2H94_04115	COG1309	transcriptional regulator
C2H94_04120	COG1956	GAF domain-containing protein
C2H94_04125	COG2199	diguanylate cyclase activity
C2H94_04125	COG2203	Gaf domain
C2H94_04135	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C2H94_04140	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2H94_04150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2H94_04155	COG0454	-acetyltransferase
C2H94_04160	COG0517	IMP dehydrogenase activity
C2H94_04165	COG0123	including yeast histone deacetylase and acetoin utilization protein
C2H94_04170	COG1360	Flagellar Motor Protein
C2H94_04175	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2H94_04180	COG1609	Transcriptional regulator
C2H94_04185	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C2H94_04185	COG1605	Chorismate mutase
C2H94_04190	COG3118	belongs to the thioredoxin family
C2H94_04195	COG4980	gas vesicle protein
C2H94_04200	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
C2H94_04205	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2H94_04210	COG1674	ftsk spoiiie
C2H94_04215	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H94_04220	COG4848	Belongs to the UPF0354 family
C2H94_04225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H94_04235	COG1363	Peptidase, m42
C2H94_04240	COG5584	Small secreted protein
C2H94_04245	COG0281	malic enzyme
C2H94_04250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H94_04255	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2H94_04265	COG0510	thiamine kinase activity
C2H94_04270	COG1523	belongs to the glycosyl hydrolase 13 family
C2H94_04285	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2H94_04290	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2H94_04300	COG2252	PERMEase
C2H94_04305	COG4473	ABC transporter
C2H94_04310	COG1131	(ABC) transporter
C2H94_04315	COG1349	DNA-binding transcription factor activity
C2H94_04320	COG1187	pseudouridine synthase activity
C2H94_04325	COG2244	polysaccharide biosynthetic process
C2H94_04330	COG2081	HI0933 family
C2H94_04335	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2H94_04345	COG5578	integral membrane protein
C2H94_04350	COG0673	inositol 2-dehydrogenase activity
C2H94_04355	COG1653	transport
C2H94_04360	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2H94_04365	COG4209	transmembrane transport
C2H94_04370	COG2207	Transcriptional regulator
C2H94_04375	COG1653	transport
C2H94_04380	COG0395	ABC-type sugar transport system, permease component
C2H94_04385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H94_04390	COG2124	cytochrome p450
C2H94_04395	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2H94_04405	COG0156	8-amino-7-oxononanoate synthase activity
C2H94_04410	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2H94_04420	COG1073	alpha beta
C2H94_04425	COG1609	Transcriptional regulator
C2H94_04430	COG1653	transport
C2H94_04435	COG1175	transmembrane transport
C2H94_04440	COG0395	ABC-type sugar transport system, permease component
C2H94_04445	COG1486	melibiose metabolic process
C2H94_04450	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2H94_04455	COG0495	leucyl-tRNA aminoacylation
C2H94_04465	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H94_04465	COG2202	Pas domain
C2H94_04470	COG2814	Major facilitator Superfamily
C2H94_04475	COG2433	Pfam Transposase IS66
C2H94_04480	COG0577	efflux transmembrane transporter activity
C2H94_04485	COG1136	(ABC) transporter
C2H94_04490	COG2205	protein histidine kinase activity
C2H94_04495	COG0745	RESPONSE REGULATOR receiver
C2H94_04500	COG0577	efflux transmembrane transporter activity
C2H94_04505	COG1136	(ABC) transporter
C2H94_04520	COG1131	(ABC) transporter
C2H94_04525	COG1725	Transcriptional regulator
C2H94_04535	COG1242	4 iron, 4 sulfur cluster binding
C2H94_04540	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C2H94_04550	COG2267	carboxylic ester hydrolase activity
C2H94_04555	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2H94_04560	COG1113	amino acid transport
C2H94_04565	COG0367	asparagine synthase
C2H94_04570	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C2H94_04575	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C2H94_04585	COG1506	peptidase
C2H94_04590	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2H94_04595	COG1116	anion transmembrane transporter activity
C2H94_04600	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2H94_04605	COG0494	nUDIX hydrolase
C2H94_04610	COG4824	toxin secretion phage lysis holin
C2H94_04615	COG0783	Belongs to the Dps family
C2H94_04630	COG1854	S-ribosylhomocysteine lyase activity
C2H94_04635	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2H94_04640	COG0288	reversible hydration of carbon dioxide
C2H94_04645	COG0254	rRNA binding
C2H94_04650	COG1271	oxidase subunit
C2H94_04655	COG1294	oxidase, subunit
C2H94_04665	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2H94_04670	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2H94_04670	COG1321	iron dependent repressor
C2H94_04675	COG1121	(ABC) transporter
C2H94_04680	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2H94_04685	COG4948	Mandelate Racemase Muconate Lactonizing
C2H94_04690	COG0318	PFAM AMP-dependent synthetase and ligase
C2H94_04695	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C2H94_04700	COG0596	Alpha beta hydrolase
C2H94_04705	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C2H94_04710	COG1169	isochorismate synthase
C2H94_04720	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2H94_04725	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2H94_04730	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C2H94_04735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H94_04740	COG0438	transferase activity, transferring glycosyl groups
C2H94_04750	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H94_04755	COG0438	transferase activity, transferring glycosyl groups
C2H94_04760	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H94_04765	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C2H94_04770	COG0058	SHG alpha-glucan phosphorylase activity
C2H94_04775	COG0297	glycogen (starch) synthase activity
C2H94_04780	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2H94_04785	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2H94_04915	COG3859	Proton-coupled thiamine transporter YuaJ
C2H94_04920	COG1247	-acetyltransferase
C2H94_04925	COG2268	Band 7 protein
C2H94_04930	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2H94_04935	COG2318	DinB family
C2H94_04945	COG1454	alcohol dehydrogenase
C2H94_04950	COG1012	belongs to the aldehyde dehydrogenase family
C2H94_04955	COG1510	regulation of RNA biosynthetic process
C2H94_04965	COG0569	domain protein
C2H94_04970	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2H94_04975	COG4682	membrane
C2H94_04980	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2H94_04985	COG0477	Major facilitator Superfamily
C2H94_04990	COG5553	Cysteine dioxygenase type I
C2H94_05000	COG1968	undecaprenyl-diphosphatase activity
C2H94_05005	COG0628	permease
C2H94_05010	COG0673	inositol 2-dehydrogenase activity
C2H94_05015	COG4806	L-rhamnose isomerase
C2H94_05020	COG3254	rhamnose metabolic process
C2H94_05025	COG1070	Carbohydrate kinase
C2H94_05030	COG1349	DNA-binding transcription factor activity
C2H94_05035	COG3347	Dehydrogenase
C2H94_05035	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_05045	COG0840	transmembrane signaling receptor activity
C2H94_05050	COG0840	transmembrane signaling receptor activity
C2H94_05055	COG0840	transmembrane signaling receptor activity
C2H94_05060	COG0840	transmembrane signaling receptor activity
C2H94_05075	COG0432	Pfam Uncharacterised protein family UPF0047
C2H94_05080	COG0366	Alpha amylase catalytic
C2H94_05085	COG1253	flavin adenine dinucleotide binding
C2H94_05090	COG2738	Putative neutral zinc metallopeptidase
C2H94_05105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2H94_05120	COG0166	Belongs to the GPI family
C2H94_05125	COG1979	alcohol dehydrogenase
C2H94_05130	COG1979	alcohol dehydrogenase
C2H94_05135	COG2155	Conserved Protein
C2H94_05140	COG1098	S1 RNA binding domain
C2H94_05145	COG0436	Aminotransferase
C2H94_05150	COG1522	sequence-specific DNA binding
C2H94_05155	COG2267	carboxylic ester hydrolase activity
C2H94_05165	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2H94_05170	COG2205	protein histidine kinase activity
C2H94_05180	COG5018	Exonuclease
C2H94_05190	COG2814	Major facilitator Superfamily
C2H94_05195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2H94_05200	COG3011	Protein conserved in bacteria
C2H94_05210	COG3290	protein histidine kinase activity
C2H94_05215	COG4565	transcriptional regulatory protein
C2H94_05220	COG1744	ABC transporter substrate-binding protein PnrA-like
C2H94_05225	COG3845	ABC transporter
C2H94_05230	COG4603	Belongs to the binding-protein-dependent transport system permease family
C2H94_05235	COG1079	Belongs to the binding-protein-dependent transport system permease family
C2H94_05240	COG3493	citrate carrier protein
C2H94_05250	COG2111	Na H antiporter
C2H94_05250	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2H94_05255	COG2111	Na H antiporter
C2H94_05260	COG1006	Multisubunit Na H antiporter MnhC subunit
C2H94_05265	COG0651	ATP synthesis coupled electron transport
C2H94_05270	COG1863	multisubunit Na H antiporter MnhE subunit
C2H94_05275	COG2212	antiporter activity
C2H94_05280	COG1320	monovalent cation:proton antiporter activity
C2H94_05285	COG2050	protein possibly involved in aromatic compounds catabolism
C2H94_05290	COG2197	response regulator
C2H94_05305	COG0142	geranyltranstransferase activity
C2H94_05320	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C2H94_05325	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C2H94_05330	COG1335	isochorismatase
C2H94_05335	COG5506	Protein of unknown function (DUF1694)
C2H94_05350	COG0628	permease
C2H94_05365	COG1418	mRNA catabolic process
C2H94_05370	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_05380	COG1511	domain protein
C2H94_05385	COG0433	COG0433 Predicted ATPase
C2H94_05385	COG1674	ftsk spoiiie
C2H94_05390	COG4499	WXG100 protein secretion system (Wss), protein YukC
C2H94_05395	COG5417	Belongs to the EsaB family
C2H94_05400	COG4842	Belongs to the WXG100 family
C2H94_05405	COG2508	Transcriptional regulator
C2H94_05405	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C2H94_05410	COG0686	Belongs to the AlaDH PNT family
C2H94_05415	COG5634	Uncharacterized conserved protein (DUF2278)
C2H94_05420	COG3251	PFAM MbtH domain protein
C2H94_05425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H94_05430	COG3433	isochorismatase activity
C2H94_05430	COG1535	isochorismatase
C2H94_05435	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2H94_05440	COG1169	isochorismate synthase
C2H94_05445	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_05450	COG2819	hydrolase of the alpha beta superfamily
C2H94_05455	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2H94_05460	COG1268	BioY protein
C2H94_05465	COG2056	Na+-H+ antiporter family
C2H94_05470	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2H94_05475	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
C2H94_05480	COG3584	3D domain protein
C2H94_05495	COG1252	NADH dehydrogenase
C2H94_05500	COG0492	ferredoxin-NADP+ reductase activity
C2H94_05510	COG0516	GMP reductase activity
C2H94_05515	COG2808	Putative FMN-binding domain
C2H94_05520	COG0456	acetyltransferase
C2H94_05525	COG0316	Belongs to the HesB IscA family
C2H94_05530	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C2H94_05535	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2H94_05540	COG4844	belongs to the
C2H94_05545	COG1252	NADH dehydrogenase
C2H94_05550	COG4837	Protein of unknown function (DUF1462)
C2H94_05555	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C2H94_05560	COG4946	Tricorn protease homolog
C2H94_05560	COG1506	peptidase
C2H94_05560	COG0823	Involved in the tonB-independent uptake of proteins
C2H94_05565	COG0083	homoserine kinase activity
C2H94_05570	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2H94_05575	COG0460	homoserine dehydrogenase
C2H94_05580	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H94_05585	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2H94_05590	COG0647	UMP catabolic process
C2H94_05595	COG2445	Protein of unknown function DUF86
C2H94_05600	COG4470	Protein conserved in bacteria
C2H94_05610	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2H94_05615	COG0739	heme binding
C2H94_05625	COG3377	Domain of unknown function (DUF1805)
C2H94_05630	COG0737	Belongs to the 5'-nucleotidase family
C2H94_05635	COG0730	response to heat
C2H94_05640	COG1801	Protein of unknown function DUF72
C2H94_05650	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2H94_05655	COG2508	Transcriptional regulator
C2H94_05660	COG2233	PERMEase
C2H94_05665	COG2233	PERMEase
C2H94_05670	COG3648	Uricase
C2H94_05670	COG3195	allantoin biosynthetic process
C2H94_05675	COG2351	hydroxyisourate hydrolase activity
C2H94_05685	COG2080	2 iron, 2 sulfur cluster binding
C2H94_05690	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2H94_05695	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C2H94_05700	COG2068	MobA-Related Protein
C2H94_05705	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C2H94_05710	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2H94_05715	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2H94_05720	COG2356	endonuclease I
C2H94_05725	COG3842	ATPase activity
C2H94_05730	COG2188	Transcriptional regulator
C2H94_05735	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H94_05740	COG0395	ABC-type sugar transport system, permease component
C2H94_05745	COG1175	transmembrane transport
C2H94_05750	COG1653	transport
C2H94_05755	COG2222	sugar isomerase
C2H94_05760	COG0322	excinuclease ABC activity
C2H94_05765	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2H94_05780	COG0346	lactoylglutathione lyase activity
C2H94_05785	COG0640	Transcriptional regulator
C2H94_05790	COG0719	Fe-S assembly protein
C2H94_05795	COG0822	iron-sulfur transferase activity
C2H94_05800	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2H94_05805	COG0719	Fe-S assembly protein
C2H94_05810	COG0396	ATPase activity
C2H94_05825	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2H94_05830	COG1464	Belongs to the NlpA lipoprotein family
C2H94_05835	COG2011	ABC-type metal ion transport system permease component
C2H94_05840	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2H94_05850	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H94_05855	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C2H94_05865	COG0509	glycine decarboxylation via glycine cleavage system
C2H94_05870	COG1393	Belongs to the ArsC family
C2H94_05875	COG1960	acyl-CoA dehydrogenase activity
C2H94_05880	COG0183	Belongs to the thiolase family
C2H94_05885	COG1024	Enoyl-CoA hydratase
C2H94_05885	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2H94_05895	COG0506	proline dehydrogenase activity
C2H94_05905	COG5577	PFAM Coat F domain
C2H94_05910	COG1846	Transcriptional regulator
C2H94_05915	COG0477	Major facilitator Superfamily
C2H94_05920	COG1942	4-Oxalocrotonate Tautomerase
C2H94_05925	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_05930	COG0583	DNA-binding transcription factor activity
C2H94_05940	COG1120	ATPase activity
C2H94_05955	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_05960	COG0783	Belongs to the Dps family
C2H94_05965	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H94_05970	COG0745	RESPONSE REGULATOR receiver
C2H94_05975	COG2205	protein histidine kinase activity
C2H94_05975	COG2770	Histidine kinase
C2H94_05985	COG1309	transcriptional regulator
C2H94_05990	COG0114	fumarate hydratase activity
C2H94_06000	COG0697	spore germination
C2H94_06005	COG0814	amino acid
C2H94_06015	COG2197	response regulator
C2H94_06020	COG4585	Histidine kinase
C2H94_06025	COG4758	membrane
C2H94_06030	COG3595	metallopeptidase activity
C2H94_06035	COG1842	Phage shock protein A
C2H94_06040	COG4758	membrane
C2H94_06045	COG2814	Major facilitator Superfamily
C2H94_06050	COG2096	Adenosyltransferase
C2H94_06055	COG1120	ATPase activity
C2H94_06060	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H94_06065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H94_06070	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_06075	COG3386	PFAM SMP-30 Gluconolaconase
C2H94_06080	COG2205	protein histidine kinase activity
C2H94_06085	COG0745	RESPONSE REGULATOR receiver
C2H94_06100	COG1191	sigma factor activity
C2H94_06110	COG2140	Oxalate decarboxylase
C2H94_06125	COG1136	(ABC) transporter
C2H94_06130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2H94_06135	COG1120	ATPase activity
C2H94_06140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H94_06145	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H94_06150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H94_06160	COG0531	amino acid
C2H94_06175	COG1988	membrane-bound metal-dependent
C2H94_06180	COG1368	sulfuric ester hydrolase activity
C2H94_06185	COG1910	domain protein
C2H94_06190	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2H94_06195	COG4149	molybdate abc transporter
C2H94_06200	COG0656	L-ascorbic acid biosynthetic process
C2H94_06210	COG0025	NhaP-type Na H and K H
C2H94_06215	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2H94_06220	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2H94_06235	COG2860	membrane
C2H94_06240	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C2H94_06245	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2H94_06250	COG2217	Heavy metal translocating P-type atpase
C2H94_06255	COG2217	Heavy metal translocating P-type atpase
C2H94_06260	COG2608	mercury ion transmembrane transporter activity
C2H94_06265	COG1937	Protein conserved in bacteria
C2H94_06270	COG0673	inositol 2-dehydrogenase activity
C2H94_06275	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2H94_06280	COG1289	transmembrane transporter activity
C2H94_06290	COG2076	Multidrug Resistance protein
C2H94_06295	COG1309	transcriptional regulator
C2H94_06300	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_06325	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C2H94_06330	COG0557	exoribonuclease II activity
C2H94_06335	COG1647	Serine aminopeptidase, S33
C2H94_06340	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2H94_06345	COG0596	Alpha beta hydrolase
C2H94_06350	COG1476	TRANSCRIPTIONal
C2H94_06355	COG1396	sequence-specific DNA binding
C2H94_06360	COG1396	sequence-specific DNA binding
C2H94_06365	COG1733	regulation of RNA biosynthetic process
C2H94_06370	COG0840	transmembrane signaling receptor activity
C2H94_06395	COG1131	(ABC) transporter
C2H94_06425	COG1174	glycine betaine transport
C2H94_06430	COG1732	Glycine betaine
C2H94_06435	COG1174	glycine betaine transport
C2H94_06440	COG0517	IMP dehydrogenase activity
C2H94_06440	COG1125	glycine betaine transport
C2H94_06445	COG1510	regulation of RNA biosynthetic process
C2H94_06450	COG1174	glycine betaine transport
C2H94_06455	COG1732	Glycine betaine
C2H94_06460	COG1174	glycine betaine transport
C2H94_06465	COG0517	IMP dehydrogenase activity
C2H94_06465	COG1125	glycine betaine transport
C2H94_06470	COG1510	regulation of RNA biosynthetic process
C2H94_06475	COG2095	MarC family integral membrane protein
C2H94_06485	COG3064	Membrane
C2H94_06490	COG4640	response to antibiotic
C2H94_06495	COG0456	acetyltransferase
C2H94_06535	COG0148	phosphopyruvate hydratase activity
C2H94_06540	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C2H94_06545	COG0149	triose-phosphate isomerase activity
C2H94_06550	COG0126	phosphoglycerate kinase activity
C2H94_06555	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2H94_06565	COG2814	Major facilitator Superfamily
C2H94_06570	COG1609	Transcriptional regulator
C2H94_06575	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H94_06585	COG0583	DNA-binding transcription factor activity
C2H94_06590	COG0697	spore germination
C2H94_06595	COG1113	amino acid transport
C2H94_06600	COG3858	chitin binding
C2H94_06605	COG1556	Lactate utilization protein
C2H94_06610	COG1139	Iron-sulfur cluster binding protein
C2H94_06615	COG0247	lactate metabolic process
C2H94_06620	COG2197	response regulator
C2H94_06625	COG4585	Histidine kinase
C2H94_06630	COG0842	Transport permease protein
C2H94_06635	COG1131	(ABC) transporter
C2H94_06640	COG0596	Alpha beta hydrolase
C2H94_06645	COG2208	phosphoserine phosphatase activity
C2H94_06650	COG3867	Arabinogalactan endo-beta-1,4-galactanase
C2H94_06655	COG1874	Beta-galactosidase
C2H94_06660	COG3833	ABC-type maltose transport systems, permease component
C2H94_06665	COG1175	transmembrane transport
C2H94_06670	COG2182	Extracellular solute-binding protein
C2H94_06675	COG1609	Transcriptional regulator
C2H94_06680	COG2186	Transcriptional regulator
C2H94_06685	COG1620	l-lactate permease
C2H94_06690	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2H94_06700	COG5039	Polysaccharide pyruvyl transferase
C2H94_06710	COG0110	maltose O-acetyltransferase activity
C2H94_06715	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2H94_06720	COG2244	polysaccharide biosynthetic process
C2H94_06725	COG1216	Glycosyl transferase, family 2
C2H94_06730	COG5039	Polysaccharide pyruvyl transferase
C2H94_06735	COG1216	Glycosyl transferase, family 2
C2H94_06745	COG0438	transferase activity, transferring glycosyl groups
C2H94_06750	COG1215	transferase activity, transferring glycosyl groups
C2H94_06755	COG0438	transferase activity, transferring glycosyl groups
C2H94_06760	COG1086	Polysaccharide biosynthesis protein
C2H94_06765	COG0489	protein tyrosine kinase activity
C2H94_06770	COG3944	biosynthesis protein
C2H94_06775	COG1396	sequence-specific DNA binding
C2H94_06780	COG2272	Belongs to the type-B carboxylesterase lipase family
C2H94_06790	COG3479	Phenolic acid decarboxylase
C2H94_06800	COG1794	racemase activity, acting on amino acids and derivatives
C2H94_06805	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2H94_06815	COG1621	beta-fructofuranosidase activity
C2H94_06820	COG1621	beta-fructofuranosidase activity
C2H94_06825	COG0531	amino acid
C2H94_06830	COG1309	transcriptional regulator
C2H94_06835	COG2076	Multidrug Resistance protein
C2H94_06840	COG2076	Multidrug Resistance protein
C2H94_06855	COG0740	serine-type endopeptidase activity
C2H94_06860	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2H94_06870	COG1554	hydrolase, family 65, central catalytic
C2H94_06875	COG5521	maltodextrose utilization protein MalA
C2H94_06880	COG3833	ABC-type maltose transport systems, permease component
C2H94_06885	COG1175	transmembrane transport
C2H94_06890	COG2182	Extracellular solute-binding protein
C2H94_06895	COG0366	Alpha amylase catalytic
C2H94_06900	COG1609	Transcriptional regulator
C2H94_06905	COG1611	Belongs to the LOG family
C2H94_06910	COG1694	Mazg nucleotide pyrophosphohydrolase
C2H94_06915	COG0659	secondary active sulfate transmembrane transporter activity
C2H94_06920	COG0288	reversible hydration of carbon dioxide
C2H94_06925	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2H94_06930	COG0577	efflux transmembrane transporter activity
C2H94_06935	COG1136	(ABC) transporter
C2H94_06940	COG5002	protein histidine kinase activity
C2H94_06945	COG0745	RESPONSE REGULATOR receiver
C2H94_06955	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C2H94_06960	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H94_06965	COG1481	regulation of sporulation
C2H94_06970	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C2H94_06975	COG1660	Displays ATPase and GTPase activities
C2H94_06980	COG1051	belongs to the nudix hydrolase family
C2H94_06985	COG0492	ferredoxin-NADP+ reductase activity
C2H94_06990	COG3883	PFAM NLP P60 protein
C2H94_06990	COG0791	NLP P60 protein
C2H94_06995	COG0457	Tetratricopeptide repeat
C2H94_07000	COG1132	(ABC) transporter
C2H94_07020	COG0140	phosphoribosyl-ATP diphosphatase activity
C2H94_07020	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2H94_07025	COG0107	imidazoleglycerol-phosphate synthase activity
C2H94_07030	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C2H94_07035	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2H94_07040	COG0131	Imidazoleglycerol-phosphate dehydratase
C2H94_07045	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C2H94_07050	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C2H94_07055	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C2H94_07060	COG4990	cell redox homeostasis
C2H94_07065	COG5297	Belongs to the glycosyl hydrolase family 6
C2H94_07070	COG0110	maltose O-acetyltransferase activity
C2H94_07075	COG0546	phosphoglycolate phosphatase activity
C2H94_07080	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C2H94_07085	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C2H94_07090	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C2H94_07095	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2H94_07100	COG0363	glucosamine-6-phosphate deaminase activity
C2H94_07105	COG2188	Transcriptional regulator
C2H94_07110	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2H94_07115	COG1846	Transcriptional regulator
C2H94_07120	COG2124	cytochrome p450
C2H94_07135	COG2814	Major facilitator Superfamily
C2H94_07140	COG1950	PFAM Membrane protein of
C2H94_07145	COG1983	PspC domain protein
C2H94_07150	COG3595	metallopeptidase activity
C2H94_07165	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2H94_07170	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2H94_07175	COG0556	nucleotide-excision repair
C2H94_07180	COG4897	Protein conserved in bacteria
C2H94_07185	COG3848	Pyruvate phosphate dikinase
C2H94_07185	COG0574	Belongs to the PEP-utilizing enzyme family
C2H94_07190	COG1309	transcriptional regulator
C2H94_07195	COG2814	Major facilitator Superfamily
C2H94_07200	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H94_07210	COG3409	Peptidoglycan-binding domain 1 protein
C2H94_07210	COG0793	Belongs to the peptidase S41A family
C2H94_07215	COG2177	Part of the ABC transporter FtsEX involved in
C2H94_07220	COG2884	Cell division ATP-binding protein ftsE
C2H94_07225	COG2010	Cytochrome c
C2H94_07230	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H94_07240	COG0653	protein targeting
C2H94_07245	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2H94_07260	COG1516	flagellar protein fliS
C2H94_07265	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C2H94_07270	COG1334	flagellar protein FlaG
C2H94_07275	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2H94_07280	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C2H94_07285	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
C2H94_07295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2H94_07300	COG1256	bacterial-type flagellum assembly
C2H94_07300	COG4786	Flagellar basal body rod
C2H94_07305	COG3418	PFAM FlgN family protein
C2H94_07310	COG2747	anti-sigma28 factor FlgM
C2H94_07320	COG1040	competence protein
C2H94_07330	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C2H94_07335	COG1307	EDD domain protein, DegV family
C2H94_07340	COG2197	response regulator
C2H94_07345	COG4585	Histidine kinase
C2H94_07350	COG1739	Uncharacterized protein family UPF0029
C2H94_07355	COG1316	TRANSCRIPTIONal
C2H94_07360	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2H94_07365	COG0438	transferase activity, transferring glycosyl groups
C2H94_07370	COG1215	transferase activity, transferring glycosyl groups
C2H94_07375	COG3206	protein involved in exopolysaccharide biosynthesis
C2H94_07380	COG3307	-O-antigen
C2H94_07385	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C2H94_07390	COG0438	transferase activity, transferring glycosyl groups
C2H94_07390	COG0297	glycogen (starch) synthase activity
C2H94_07395	COG2244	polysaccharide biosynthetic process
C2H94_07410	COG2247	cell wall binding repeat
C2H94_07410	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H94_07415	COG2385	sporulation resulting in formation of a cellular spore
C2H94_07415	COG2247	cell wall binding repeat
C2H94_07425	COG1316	TRANSCRIPTIONal
C2H94_07430	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2H94_07450	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2H94_07455	COG1134	teichoic acid transport
C2H94_07460	COG1682	transport, permease protein
C2H94_07470	COG0463	Glycosyl transferase, family 2
C2H94_07515	COG4193	domain, Protein
C2H94_07520	COG1482	cell wall glycoprotein biosynthetic process
C2H94_07525	COG0697	spore germination
C2H94_07530	COG0814	amino acid
C2H94_07540	COG2814	Major facilitator Superfamily
C2H94_07545	COG1316	TRANSCRIPTIONal
C2H94_07550	COG0561	phosphatase activity
C2H94_07555	COG0791	NLP P60 protein
C2H94_07565	COG2843	Capsule synthesis protein
C2H94_07575	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2H94_07580	COG1609	Transcriptional regulator
C2H94_07585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H94_07590	COG1869	D-ribose catabolic process
C2H94_07595	COG1129	ABC transporter
C2H94_07600	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2H94_07605	COG1879	ABC-type sugar transport system periplasmic component
C2H94_07610	COG3103	Sh3 type 3 domain protein
C2H94_07620	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2H94_07625	COG3527	Alpha-acetolactate decarboxylase
C2H94_07630	COG0028	Belongs to the TPP enzyme family
C2H94_07635	COG0583	DNA-binding transcription factor activity
C2H94_07640	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2H94_07655	COG5337	Spore coat protein CotH
C2H94_07665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2H94_07675	COG0405	Gamma-glutamyltransferase
C2H94_07680	COG1522	sequence-specific DNA binding
C2H94_07685	COG2059	Chromate
C2H94_07690	COG2059	Chromate
C2H94_07695	COG1515	deoxyribonuclease V activity
C2H94_07705	COG5444	nuclease activity
C2H94_07720	COG3878	Protein conserved in bacteria
C2H94_07725	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C2H94_07730	COG4464	protein tyrosine phosphatase activity
C2H94_07735	COG0489	protein tyrosine kinase activity
C2H94_07740	COG3944	biosynthesis protein
C2H94_07750	COG4715	Zinc finger, swim domain protein
C2H94_07755	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2H94_07760	COG0561	phosphatase activity
C2H94_07765	COG1349	DNA-binding transcription factor activity
C2H94_07770	COG0629	single-stranded DNA binding
C2H94_07785	COG3764	Sortase (surface protein transpeptidase)
C2H94_07795	COG3279	Response regulator of the LytR AlgR family
C2H94_07805	COG1970	mechanosensitive ion channel activity
C2H94_07810	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2H94_07815	COG0457	Tetratricopeptide repeat
C2H94_07820	COG4786	Flagellar basal body rod
C2H94_07825	COG4786	Flagellar basal body rod
C2H94_07830	COG1077	Cell shape determining protein MreB Mrl
C2H94_07835	COG1609	Transcriptional regulator
C2H94_07845	COG1846	Transcriptional regulator
C2H94_07850	COG2814	Major facilitator Superfamily
C2H94_07855	COG3420	alginic acid biosynthetic process
C2H94_07860	COG1953	Uracil, thiamine, allantoin
C2H94_07865	COG0477	Major facilitator Superfamily
C2H94_07870	COG1335	isochorismatase
C2H94_07880	COG0004	ammonium transporteR
C2H94_07885	COG0347	Belongs to the P(II) protein family
C2H94_07890	COG0671	phosphoesterase, PA-phosphatase related
C2H94_07900	COG0739	heme binding
C2H94_07905	COG1247	-acetyltransferase
C2H94_07920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2H94_07925	COG0789	Transcriptional regulator
C2H94_07935	COG2910	NAD(P)H-binding
C2H94_07940	COG1959	2 iron, 2 sulfur cluster binding
C2H94_07945	COG0804	urea catabolic process
C2H94_07950	COG0832	Belongs to the urease beta subunit family
C2H94_07955	COG0831	urea catabolic process
C2H94_07970	COG3237	CsbD-like
C2H94_07975	COG1994	Peptidase M50
C2H94_07980	COG0457	Tetratricopeptide repeat
C2H94_07985	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2H94_07990	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2H94_08000	COG2304	oxidoreductase activity
C2H94_08010	COG2304	oxidoreductase activity
C2H94_08015	COG2385	sporulation resulting in formation of a cellular spore
C2H94_08020	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2H94_08030	COG4836	Membrane
C2H94_08040	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C2H94_08045	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C2H94_08050	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C2H94_08055	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C2H94_08060	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2H94_08075	COG0356	it plays a direct role in the translocation of protons across the membrane
C2H94_08085	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C2H94_08090	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2H94_08095	COG4475	Protein of unknown function (DUF436)
C2H94_08100	COG0698	ribose 5-phosphate isomerase
C2H94_08105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2H94_08110	COG1971	Probably functions as a manganese efflux pump
C2H94_08115	COG0009	L-threonylcarbamoyladenylate synthase
C2H94_08120	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2H94_08140	COG2890	protein-(glutamine-N5) methyltransferase activity
C2H94_08145	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C2H94_08150	COG0346	lactoylglutathione lyase activity
C2H94_08155	COG0789	Transcriptional regulator
C2H94_08160	COG0679	Auxin Efflux Carrier
C2H94_08165	COG0281	malic enzyme
C2H94_08170	COG1435	thymidine kinase activity
C2H94_08180	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C2H94_08185	COG1494	fructose-1,6-bisphosphatase
C2H94_08190	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2H94_08195	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2H94_08200	COG0191	fructose-bisphosphate aldolase activity
C2H94_08205	COG2204	response regulator
C2H94_08210	COG4821	SIS domain
C2H94_08220	COG3343	RNA polymerase activity
C2H94_08225	COG1960	acyl-CoA dehydrogenase activity
C2H94_08230	COG2181	nitrate reductase activity
C2H94_08230	COG0247	lactate metabolic process
C2H94_08235	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2H94_08240	COG4294	response to UV
C2H94_08250	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2H94_08255	COG1132	(ABC) transporter
C2H94_08260	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2H94_08270	COG2181	nitrate reductase activity
C2H94_08275	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2H94_08280	COG1140	nitrate reductase beta subunit
C2H94_08285	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2H94_08290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2H94_08300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2H94_08305	COG2223	nitrite transmembrane transporter activity
C2H94_08310	COG0018	arginyl-trna synthetase
C2H94_08315	COG4506	Protein conserved in bacteria
C2H94_08330	COG0535	radical SAM domain protein
C2H94_08340	COG1131	(ABC) transporter
C2H94_08345	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C2H94_08350	COG0612	Peptidase, M16
C2H94_08355	COG0612	Peptidase, M16
C2H94_08365	COG3391	amine dehydrogenase activity
C2H94_08370	COG3391	amine dehydrogenase activity
C2H94_08380	COG0457	Tetratricopeptide repeat
C2H94_08395	COG0010	Belongs to the arginase family
C2H94_08400	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C2H94_08405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2H94_08420	COG1994	Peptidase M50
C2H94_08425	COG1942	4-Oxalocrotonate Tautomerase
C2H94_08430	COG1846	Transcriptional regulator
C2H94_08435	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2H94_08440	COG0477	Major facilitator Superfamily
C2H94_08445	COG1959	2 iron, 2 sulfur cluster binding
C2H94_08450	COG3465	dGTPase activity
C2H94_08455	COG1078	dGTPase activity
C2H94_08460	COG4844	belongs to the
C2H94_08470	COG0697	spore germination
C2H94_08475	COG0095	Lipoate-protein ligase
C2H94_08480	COG0583	DNA-binding transcription factor activity
C2H94_08485	COG0280	phosphate acetyltransferase
C2H94_08490	COG3253	May function as heme-dependent peroxidase
C2H94_08495	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_08500	COG0436	Aminotransferase
C2H94_08505	COG2814	Major facilitator Superfamily
C2H94_08510	COG0151	Belongs to the GarS family
C2H94_08515	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_08520	COG1917	Cupin 2, conserved barrel domain protein
C2H94_08525	COG0077	Prephenate dehydratase
C2H94_08530	COG2814	Major facilitator Superfamily
C2H94_08535	COG0833	amino acid
C2H94_08540	COG4187	Peptidase family M20/M25/M40
C2H94_08545	COG1012	belongs to the aldehyde dehydrogenase family
C2H94_08550	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2H94_08560	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C2H94_08565	COG1091	dTDP-4-dehydrorhamnose reductase activity
C2H94_08570	COG1088	dTDP-glucose 4,6-dehydratase activity
C2H94_08575	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C2H94_08580	COG3980	spore coat polysaccharide biosynthesis protein
C2H94_08585	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
C2H94_08590	COG2089	acid synthase
C2H94_08595	COG0456	acetyltransferase
C2H94_08600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2H94_08605	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C2H94_08610	COG0463	Glycosyl transferase, family 2
C2H94_08625	COG2363	Small membrane protein
C2H94_08630	COG2233	PERMEase
C2H94_08640	COG1012	belongs to the aldehyde dehydrogenase family
C2H94_08645	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C2H94_08650	COG1216	Glycosyl transferase, family 2
C2H94_08665	COG1695	Transcriptional regulator
C2H94_08670	COG0351	phosphomethylpyrimidine kinase
C2H94_08685	COG1621	beta-fructofuranosidase activity
C2H94_08690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H94_08690	COG1263	PTS System
C2H94_08695	COG2116	formate transmembrane transporter activity
C2H94_08700	COG3711	transcriptional antiterminator
C2H94_08710	COG1404	Belongs to the peptidase S8 family
C2H94_08715	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H94_08720	COG0778	Nitroreductase
C2H94_08725	COG0772	Belongs to the SEDS family
C2H94_08740	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2H94_08745	COG1845	cytochrome c oxidase, subunit III
C2H94_08750	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2H94_08755	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2H94_08760	COG2261	transglycosylase associated protein
C2H94_08765	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C2H94_08770	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C2H94_08775	COG2246	polysaccharide biosynthetic process
C2H94_08780	COG1309	transcriptional regulator
C2H94_08790	COG3162	membrane
C2H94_08795	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H94_08800	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C2H94_08805	COG2837	iron assimilation
C2H94_08810	COG2822	iron ion transport
C2H94_08825	COG0352	thiamine-phosphate diphosphorylase activity
C2H94_08830	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C2H94_08835	COG0583	DNA-binding transcription factor activity
C2H94_08840	COG1380	Effector of murein hydrolase LrgA
C2H94_08845	COG1346	cytolysis
C2H94_08850	COG2814	Major facilitator Superfamily
C2H94_08855	COG4895	conserved protein (DUF2196)
C2H94_08860	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2H94_08865	COG0346	lactoylglutathione lyase activity
C2H94_08875	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H94_08880	COG1404	Belongs to the peptidase S8 family
C2H94_08885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H94_08885	COG1263	PTS System
C2H94_08890	COG3711	transcriptional antiterminator
C2H94_08895	COG1442	glycosyl transferase family 8
C2H94_08900	COG5522	Integral membrane protein (intg_mem_TP0381)
C2H94_08905	COG1846	Transcriptional regulator
C2H94_08910	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2H94_08915	COG2234	aminopeptidase activity
C2H94_08930	COG2814	Major facilitator Superfamily
C2H94_08935	COG2357	RelA SpoT domain protein
C2H94_08940	COG1575	Belongs to the MenA family. Type 1 subfamily
C2H94_08955	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H94_08960	COG1696	Membrane protein involved in D-alanine export
C2H94_08965	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H94_08970	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C2H94_08975	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
C2H94_08980	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2H94_08985	COG1486	melibiose metabolic process
C2H94_08990	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2H94_08995	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H94_09000	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H94_09005	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H94_09005	COG3711	transcriptional antiterminator
C2H94_09015	COG2094	Belongs to the DNA glycosylase MPG family
C2H94_09020	COG0753	catalase activity
C2H94_09025	COG2814	Major facilitator Superfamily
C2H94_09030	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2H94_09035	COG1131	(ABC) transporter
C2H94_09055	COG1595	DNA-templated transcription, initiation
C2H94_09060	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2H94_09065	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2H94_09070	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2H94_09075	COG4988	ABC transporter
C2H94_09080	COG1294	oxidase, subunit
C2H94_09085	COG1271	oxidase subunit
C2H94_09090	COG3493	citrate carrier protein
C2H94_09095	COG0501	Belongs to the peptidase M48B family
C2H94_09105	COG0726	polysaccharide deacetylase
C2H94_09120	COG3842	ATPase activity
C2H94_09125	COG2508	Transcriptional regulator
C2H94_09130	COG1012	belongs to the aldehyde dehydrogenase family
C2H94_09135	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H94_09150	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2H94_09160	COG4585	Histidine kinase
C2H94_09165	COG2197	response regulator
C2H94_09170	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2H94_09180	COG4894	glucomannan catabolic process
C2H94_09185	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2H94_09190	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2H94_09195	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_09200	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2H94_09205	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2H94_09210	COG2610	gluconate transmembrane transporter activity
C2H94_09215	COG0500	methyltransferase
C2H94_09220	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2H94_09235	COG0693	protein deglycase activity
C2H94_09235	COG0753	catalase activity
C2H94_09240	COG2851	Citrate transporter
C2H94_09245	COG2273	Hydrolase Family 16
C2H94_09250	COG3711	transcriptional antiterminator
C2H94_09260	COG2270	Major facilitator Superfamily
C2H94_09265	COG0513	Belongs to the DEAD box helicase family
C2H94_09270	COG3401	FG-GAP repeat protein
C2H94_09270	COG2755	lipolytic protein G-D-S-L family
C2H94_09340	COG3209	COG3209 Rhs family protein
C2H94_09345	COG0697	spore germination
C2H94_09350	COG0589	response to stress
C2H94_09355	COG2723	6-phospho-beta-galactosidase activity
C2H94_09360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H94_09360	COG1263	PTS System
C2H94_09360	COG2190	(PTS) system
C2H94_09405	COG3507	Belongs to the glycosyl hydrolase 43 family
C2H94_09420	COG2986	histidine ammonia-lyase
C2H94_09425	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C2H94_09430	COG1228	amidohydrolase
C2H94_09435	COG0010	Belongs to the arginase family
C2H94_09440	COG0833	amino acid
C2H94_09445	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C2H94_09450	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2H94_09455	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C2H94_09460	COG2390	Transcriptional regulator
C2H94_09470	COG3192	ethanolamine utilization protein
C2H94_09475	COG2079	MmgE PrpD family protein
C2H94_09480	COG1473	amidohydrolase
C2H94_09485	COG1126	abc transporter atp-binding protein
C2H94_09490	COG0765	amino acid transport
C2H94_09495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H94_09500	COG0456	acetyltransferase
C2H94_09505	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H94_09515	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C2H94_09520	COG0561	phosphatase activity
C2H94_09550	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H94_09555	COG5294	Protein conserved in bacteria
C2H94_09560	COG0577	efflux transmembrane transporter activity
C2H94_09565	COG1136	(ABC) transporter
C2H94_09570	COG2205	protein histidine kinase activity
C2H94_09575	COG0745	RESPONSE REGULATOR receiver
C2H94_09580	COG0191	fructose-bisphosphate aldolase activity
C2H94_09585	COG1082	Xylose isomerase domain protein TIM barrel
C2H94_09590	COG1082	Xylose isomerase domain protein TIM barrel
C2H94_09595	COG0673	inositol 2-dehydrogenase activity
C2H94_09600	COG2814	Major facilitator Superfamily
C2H94_09605	COG1082	Xylose isomerase domain protein TIM barrel
C2H94_09610	COG3962	Belongs to the TPP enzyme family
C2H94_09615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H94_09625	COG1012	belongs to the aldehyde dehydrogenase family
C2H94_09630	COG1349	DNA-binding transcription factor activity
C2H94_09635	COG0667	Aldo Keto reductase
C2H94_09650	COG2814	Major facilitator Superfamily
C2H94_09655	COG0326	Molecular chaperone. Has ATPase activity
C2H94_09665	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_09670	COG1309	transcriptional regulator
C2H94_09675	COG1012	belongs to the aldehyde dehydrogenase family
C2H94_09685	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2H94_09695	COG1714	RDD family
C2H94_09700	COG2311	Membrane
C2H94_09705	COG1917	Cupin 2, conserved barrel domain protein
C2H94_09710	COG1309	transcriptional regulator
C2H94_09715	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_09720	COG1846	Transcriptional regulator
C2H94_09725	COG1380	Effector of murein hydrolase LrgA
C2H94_09730	COG1346	cytolysis
C2H94_09735	COG5039	Polysaccharide pyruvyl transferase
C2H94_09740	COG1929	Belongs to the glycerate kinase type-1 family
C2H94_09745	COG1802	Transcriptional regulator
C2H94_09750	COG1070	Carbohydrate kinase
C2H94_09755	COG2610	gluconate transmembrane transporter activity
C2H94_09760	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C2H94_09765	COG0450	alkyl hydroperoxide reductase
C2H94_09770	COG3634	alkyl hydroperoxide reductase activity
C2H94_09780	COG2723	6-phospho-beta-galactosidase activity
C2H94_09790	COG1263	PTS System
C2H94_09790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H94_09795	COG2188	Transcriptional regulator
C2H94_09810	COG1131	(ABC) transporter
C2H94_09815	COG1994	Peptidase M50
C2H94_09820	COG0535	radical SAM domain protein
C2H94_09830	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
C2H94_09850	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2H94_09860	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C2H94_09875	COG1063	alcohol dehydrogenase
C2H94_09895	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
C2H94_09900	COG0456	acetyltransferase
C2H94_09905	COG0457	Tetratricopeptide repeat
C2H94_09915	COG0010	Belongs to the arginase family
C2H94_09920	COG0833	amino acid
C2H94_09925	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2H94_09930	COG3829	transcription factor binding
C2H94_09940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H94_09945	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C2H94_09950	COG4853	Protein conserved in bacteria
C2H94_09955	COG4863	YycH protein
C2H94_09960	COG5002	protein histidine kinase activity
C2H94_09965	COG0745	RESPONSE REGULATOR receiver
C2H94_09995	COG0346	lactoylglutathione lyase activity
C2H94_10000	COG0305	Participates in initiation and elongation during chromosome replication
C2H94_10015	COG3093	addiction module antidote protein HigA
C2H94_10020	COG2807	transmembrane transport
C2H94_10025	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2H94_10030	COG0359	binds to the 23S rRNA
C2H94_10035	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
C2H94_10040	COG4241	membrane
C2H94_10050	COG5577	PFAM Coat F domain
C2H94_10055	COG1733	regulation of RNA biosynthetic process
C2H94_10060	COG1227	inorganic diphosphatase activity
C2H94_10070	COG2271	Major facilitator Superfamily
C2H94_10075	COG4978	Transcriptional regulator
C2H94_10075	COG0789	Transcriptional regulator
C2H94_10085	COG4319	ketosteroid isomerase
C2H94_10095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H94_10100	COG1846	Transcriptional regulator
C2H94_10105	COG2153	protein acetylation
C2H94_10110	COG2364	Membrane
C2H94_10115	COG0456	acetyltransferase
C2H94_10125	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2H94_10130	COG1331	Highly conserved protein containing a thioredoxin domain
C2H94_10145	COG0789	Transcriptional regulator
C2H94_10150	COG0697	spore germination
C2H94_10155	COG1331	Highly conserved protein containing a thioredoxin domain
C2H94_10160	COG1266	CAAX protease self-immunity
C2H94_10165	COG0477	Major facilitator Superfamily
C2H94_10165	COG2814	Major facilitator Superfamily
C2H94_10170	COG0110	maltose O-acetyltransferase activity
C2H94_10175	COG0346	lactoylglutathione lyase activity
C2H94_10180	COG1609	Transcriptional regulator
C2H94_10185	COG0708	Exodeoxyribonuclease III
C2H94_10190	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2H94_10195	COG0629	single-stranded DNA binding
C2H94_10200	COG0360	Binds together with S18 to 16S ribosomal RNA
C2H94_10205	COG0012	GTP binding
C2H94_10210	COG0243	molybdopterin cofactor binding
C2H94_10215	COG4481	Protein conserved in bacteria
C2H94_10220	COG3949	Membrane
C2H94_10230	COG1475	DNA binding
C2H94_10235	COG1192	Involved in chromosome partitioning
C2H94_10245	COG1475	DNA binding
C2H94_10250	COG0357	Ribosomal RNA small subunit methyltransferase G
C2H94_10255	COG0445	tRNA wobble uridine modification
C2H94_10260	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C2H94_10265	COG1847	R3H domain protein
C2H94_10270	COG0706	membrane insertase activity
C2H94_10275	COG0594	ribonuclease P activity
C2H94_10285	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C2H94_10290	COG0592	DNA-directed DNA polymerase activity
C2H94_10295	COG2501	S4 domain
C2H94_10300	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2H94_10310	COG0187	DNA topoisomerase II activity
C2H94_10315	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2H94_10350	COG0517	IMP dehydrogenase activity
C2H94_10350	COG0516	GMP reductase activity
C2H94_10355	COG1686	Belongs to the peptidase S11 family
C2H94_10360	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C2H94_10365	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C2H94_10370	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C2H94_10380	COG1428	Deoxynucleoside kinase
C2H94_10385	COG1428	Deoxynucleoside kinase
C2H94_10390	COG3858	chitin binding
C2H94_10390	COG1388	LysM domain
C2H94_10395	COG1335	isochorismatase
C2H94_10400	COG0590	tRNA wobble adenosine to inosine editing
C2H94_10410	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C2H94_10415	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C2H94_10420	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C2H94_10465	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
C2H94_10475	COG1982	Orn Lys Arg decarboxylase major
C2H94_10480	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C2H94_10485	COG3870	Protein conserved in bacteria
C2H94_10490	COG1728	Protein conserved in bacteria
C2H94_10495	COG0470	DNA polymerase III
C2H94_10500	COG1774	PSP1 C-terminal conserved region
C2H94_10505	COG4467	Involved in initiation control of chromosome replication
C2H94_10510	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C2H94_10515	COG2827	Endonuclease containing a URI domain
C2H94_10520	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2H94_10525	COG2002	toxin-antitoxin pair type II binding
C2H94_10530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H94_10530	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H94_10535	COG0084	hydrolase, TatD family'
C2H94_10540	COG3584	3D domain protein
C2H94_10540	COG3583	domain protein
C2H94_10545	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C2H94_10550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2H94_10560	COG4466	Protein conserved in bacteria
C2H94_10570	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C2H94_10575	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2H94_10580	COG0251	oxidation-reduction process
C2H94_10585	COG2088	sporulation resulting in formation of a cellular spore
C2H94_10590	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2H94_10595	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2H94_10600	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C2H94_10605	COG0193	aminoacyl-tRNA hydrolase activity
C2H94_10615	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2H94_10620	COG2002	toxin-antitoxin pair type II binding
C2H94_10625	COG2244	polysaccharide biosynthetic process
C2H94_10630	COG3956	TIGRFAM MazG family protein
C2H94_10635	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C2H94_10650	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C2H94_10655	COG1098	S1 RNA binding domain
C2H94_10670	COG2208	phosphoserine phosphatase activity
C2H94_10675	COG2304	oxidoreductase activity
C2H94_10680	COG0515	serine threonine protein kinase
C2H94_10685	COG0037	tRNA processing
C2H94_10690	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C2H94_10695	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2H94_10700	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C2H94_10705	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C2H94_10710	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2H94_10715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2H94_10720	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2H94_10725	COG0512	Glutamine amidotransferase of anthranilate synthase
C2H94_10730	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2H94_10735	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2H94_10740	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2H94_10745	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2H94_10750	COG1396	sequence-specific DNA binding
C2H94_10755	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2H94_10760	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2H94_10840	COG4463	regulation of RNA biosynthetic process
C2H94_10845	COG3880	PFAM UvrB UvrC protein
C2H94_10850	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C2H94_10855	COG0542	response to heat
C2H94_10860	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2H94_10865	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C2H94_10870	COG4956	integral membrane protein (PIN domain superfamily)
C2H94_10875	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C2H94_10880	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C2H94_10885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2H94_10895	COG1045	serine acetyltransferase
C2H94_10900	COG0215	cysteine-tRNA ligase activity
C2H94_10905	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C2H94_10910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2H94_10915	COG3688	RNA-binding protein containing a PIN domain
C2H94_10920	COG1595	DNA-templated transcription, initiation
C2H94_10930	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2H94_10935	COG0250	Participates in transcription elongation, termination and antitermination
C2H94_10945	COG0081	regulation of translation
C2H94_10950	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C2H94_10960	COG2813	Specifically methylates the guanine in position
C2H94_10965	COG0085	RNA polymerase activity
C2H94_10970	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C2H94_10975	COG1358	cellular component organization or biogenesis
C2H94_10980	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C2H94_10985	COG0049	tRNA binding
C2H94_10990	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2H94_10995	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2H94_11000	COG0596	Alpha beta hydrolase
C2H94_11010	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C2H94_11015	COG0088	Forms part of the polypeptide exit tunnel
C2H94_11025	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C2H94_11045	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2H94_11055	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C2H94_11060	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C2H94_11070	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C2H94_11080	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C2H94_11085	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C2H94_11090	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C2H94_11095	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C2H94_11105	COG0200	Binds to the 23S rRNA
C2H94_11110	COG0201	protein transport
C2H94_11115	COG0563	adenylate kinase activity
C2H94_11120	COG0024	Methionine aminopeptidase
C2H94_11125	COG2163	COG2163 Ribosomal protein L14E L6E L27E
C2H94_11135	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2H94_11140	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C2H94_11145	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C2H94_11150	COG0202	RNA polymerase activity
C2H94_11155	COG0203	ribosomal protein L17
C2H94_11160	COG1122	ATPase activity
C2H94_11165	COG1122	ATPase activity
C2H94_11170	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C2H94_11175	COG0101	tRNA pseudouridine synthase activity
C2H94_11180	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2H94_11185	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C2H94_11190	COG2226	methyltransferase
C2H94_11200	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H94_11205	COG0489	protein tyrosine kinase activity
C2H94_11215	COG2194	sulfuric ester hydrolase activity
C2H94_11220	COG0726	polysaccharide deacetylase
C2H94_11320	COG0659	secondary active sulfate transmembrane transporter activity
C2H94_11325	COG0385	Bile acid
C2H94_11330	COG2819	hydrolase of the alpha beta superfamily
C2H94_11335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H94_11340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H94_11345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H94_11350	COG2207	Transcriptional regulator
C2H94_11350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H94_11355	COG3876	Protein conserved in bacteria
C2H94_11360	COG1472	Belongs to the glycosyl hydrolase 3 family
C2H94_11365	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2H94_11370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H94_11370	COG1263	PTS System
C2H94_11375	COG1737	Transcriptional regulator
C2H94_11380	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C2H94_11385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H94_11390	COG1683	Conserved Protein
C2H94_11420	COG1595	DNA-templated transcription, initiation
C2H94_11425	COG5662	AntiSigma factor
C2H94_11430	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C2H94_11435	COG4856	YbbR-like protein
C2H94_11440	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2H94_11445	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2H94_11455	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2H94_11460	COG2169	Transcriptional regulator
C2H94_11465	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2H94_11470	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2H94_11475	COG3002	Belongs to the UPF0753 family
C2H94_11480	COG0288	reversible hydration of carbon dioxide
C2H94_11490	COG5609	conserved protein (DUF2294)
C2H94_11495	COG0640	Transcriptional regulator
C2H94_11500	COG2814	Major facilitator Superfamily
C2H94_11515	COG0596	Alpha beta hydrolase
C2H94_11520	COG0745	RESPONSE REGULATOR receiver
C2H94_11525	COG0642	Histidine kinase
C2H94_11535	COG0515	serine threonine protein kinase
C2H94_11550	COG1113	amino acid transport
C2H94_11565	COG2602	Beta-lactamase
C2H94_11570	COG2124	cytochrome p450
C2H94_11585	COG0584	glycerophosphoryl diester phosphodiesterase
C2H94_11590	COG2271	Major facilitator Superfamily
C2H94_11605	COG0456	acetyltransferase
C2H94_11605	COG1846	Transcriptional regulator
C2H94_11610	COG2271	Major facilitator Superfamily
C2H94_11620	COG3409	Peptidoglycan-binding domain 1 protein
C2H94_11625	COG0697	spore germination
C2H94_11630	COG1917	Cupin 2, conserved barrel domain protein
C2H94_11630	COG2207	Transcriptional regulator
C2H94_11635	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C2H94_11640	COG3591	Belongs to the peptidase S1B family
C2H94_11650	COG0596	Alpha beta hydrolase
C2H94_11655	COG1183	phosphatidylcholine synthase activity
C2H94_11660	COG0586	Pfam SNARE associated Golgi protein
C2H94_11665	COG0688	phosphatidylethanolamine metabolic process
C2H94_11675	COG2312	Erythromycin esterase
C2H94_11680	COG1054	Belongs to the UPF0176 family
C2H94_11685	COG1301	dicarboxylic acid transport
C2H94_11690	COG2190	(PTS) system
C2H94_11690	COG1263	PTS System
C2H94_11690	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H94_11695	COG0363	glucosamine-6-phosphate deaminase activity
C2H94_11700	COG2188	Transcriptional regulator
C2H94_11710	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2H94_11715	COG0833	amino acid
C2H94_11720	COG2040	homocysteine
C2H94_11730	COG1115	amino acid carrier protein
C2H94_11735	COG2066	Belongs to the glutaminase family
C2H94_11740	COG4191	Histidine kinase
C2H94_11745	COG0784	Response regulator, receiver
C2H94_11755	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2H94_11760	COG1012	belongs to the aldehyde dehydrogenase family
C2H94_11765	COG2271	Major facilitator Superfamily
C2H94_11770	COG4948	Mandelate Racemase Muconate Lactonizing
C2H94_11775	COG2186	Transcriptional regulator
C2H94_11780	COG2721	sulfolactate sulfo-lyase activity
C2H94_11785	COG3173	Aminoglycoside phosphotransferase
C2H94_11795	COG0697	spore germination
C2H94_11800	COG0745	RESPONSE REGULATOR receiver
C2H94_11805	COG2205	protein histidine kinase activity
C2H94_11810	COG1131	(ABC) transporter
C2H94_11825	COG3773	Cell wall hydrolase
C2H94_11830	COG2304	oxidoreductase activity
C2H94_11840	COG3540	Alkaline phosphatase
C2H94_11845	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2H94_11850	COG0805	protein transport
C2H94_11855	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C2H94_11860	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2H94_11865	COG0477	Major facilitator Superfamily
C2H94_11870	COG1309	transcriptional regulator
C2H94_11875	COG0252	asparaginase activity
C2H94_11880	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C2H94_11885	COG1714	RDD family
C2H94_11890	COG1405	negative regulation of cell septum assembly
C2H94_11890	COG3012	SEC-C Motif Domain Protein
C2H94_11895	COG3290	protein histidine kinase activity
C2H94_11900	COG3279	Response regulator of the LytR AlgR family
C2H94_11905	COG4555	ABC transporter
C2H94_11910	COG1668	transmembrane transport
C2H94_11915	COG0667	Aldo Keto reductase
C2H94_11925	COG1595	DNA-templated transcription, initiation
C2H94_11930	COG1595	DNA-templated transcription, initiation
C2H94_11935	COG1876	peptidase activity
C2H94_11940	COG0457	Tetratricopeptide repeat
C2H94_11945	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_11950	COG0366	Alpha amylase catalytic
C2H94_11955	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2H94_11960	COG1121	(ABC) transporter
C2H94_11965	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2H94_11970	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H94_11975	COG2310	stress, protein
C2H94_11980	COG2310	stress, protein
C2H94_11985	COG2310	stress, protein
C2H94_11990	COG0861	Integral membrane protein TerC family
C2H94_12000	COG3853	Toxic anion resistance protein (TelA)
C2H94_12005	COG0477	Major facilitator Superfamily
C2H94_12015	COG2814	Major facilitator Superfamily
C2H94_12020	COG0640	Transcriptional regulator
C2H94_12025	COG0517	IMP dehydrogenase activity
C2H94_12025	COG4175	Glycine betaine
C2H94_12030	COG4176	ABC-type proline glycine betaine transport system permease component
C2H94_12035	COG2113	Glycine betaine
C2H94_12040	COG1473	amidohydrolase
C2H94_12045	COG1288	antiporter activity
C2H94_12055	COG0366	Alpha amylase catalytic
C2H94_12060	COG0039	L-malate dehydrogenase activity
C2H94_12065	COG1620	l-lactate permease
C2H94_12070	COG2814	Major facilitator Superfamily
C2H94_12075	COG1846	Transcriptional regulator
C2H94_12080	COG1280	lysine exporter protein (LysE YggA)
C2H94_12085	COG3403	YqcI/YcgG family
C2H94_12090	COG1113	amino acid transport
C2H94_12095	COG3665	Urea carboxylase-associated protein
C2H94_12100	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C2H94_12105	COG1660	Displays ATPase and GTPase activities
C2H94_12115	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2H94_12120	COG2226	methyltransferase
C2H94_12125	COG0583	DNA-binding transcription factor activity
C2H94_12130	COG3458	cephalosporin-C deacetylase activity
C2H94_12135	COG3541	Predicted nucleotidyltransferase
C2H94_12140	COG0506	proline dehydrogenase activity
C2H94_12145	COG1012	belongs to the aldehyde dehydrogenase family
C2H94_12150	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H94_12155	COG2508	Transcriptional regulator
C2H94_12160	COG3689	TIGRFAM TIGR03943 family protein
C2H94_12165	COG0701	Predicted permease
C2H94_12170	COG2267	carboxylic ester hydrolase activity
C2H94_12175	COG0492	ferredoxin-NADP+ reductase activity
C2H94_12180	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2H94_12180	COG1587	Uroporphyrinogen-III synthase
C2H94_12185	COG2146	nitrite reductase [NAD(P)H] activity
C2H94_12190	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2H94_12195	COG0243	molybdopterin cofactor binding
C2H94_12200	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2H94_12205	COG2223	nitrite transmembrane transporter activity
C2H94_12210	COG1469	GTP cyclohydrolase I activity
C2H94_12215	COG1376	ErfK ybiS ycfS ynhG family protein
C2H94_12220	COG0523	cobalamin synthesis protein
C2H94_12225	COG0765	amino acid transport
C2H94_12230	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H94_12235	COG1714	RDD family
C2H94_12245	COG1846	Transcriptional regulator
C2H94_12255	COG3842	ATPase activity
C2H94_12260	COG2723	6-phospho-beta-galactosidase activity
C2H94_12270	COG3209	COG3209 Rhs family protein
C2H94_12275	COG3290	protein histidine kinase activity
C2H94_12275	COG0840	transmembrane signaling receptor activity
C2H94_12280	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2H94_12285	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C2H94_12290	COG1733	regulation of RNA biosynthetic process
C2H94_12295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H94_12300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H94_12305	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H94_12310	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C2H94_12315	COG2814	Major facilitator Superfamily
C2H94_12325	COG0697	spore germination
C2H94_12330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H94_12340	COG2364	Membrane
C2H94_12345	COG1126	abc transporter atp-binding protein
C2H94_12350	COG0765	amino acid transport
C2H94_12355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H94_12360	COG0583	DNA-binding transcription factor activity
C2H94_12365	COG0163	prenyltransferase activity
C2H94_12370	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2H94_12385	COG0596	Alpha beta hydrolase
C2H94_12390	COG3104	oligopeptide transport
C2H94_12395	COG5434	Belongs to the glycosyl hydrolase 28 family
C2H94_12405	COG0697	spore germination
C2H94_12415	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2H94_12420	COG1136	(ABC) transporter
C2H94_12425	COG0577	efflux transmembrane transporter activity
C2H94_12430	COG0745	RESPONSE REGULATOR receiver
C2H94_12435	COG3850	Histidine kinase
C2H94_12435	COG5002	protein histidine kinase activity
C2H94_12440	COG0457	Tetratricopeptide repeat
C2H94_12460	COG0527	aspartate kinase activity
C2H94_12465	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H94_12470	COG4605	iron ion homeostasis
C2H94_12475	COG4604	ABC transporter, ATP-binding protein
C2H94_12480	COG4607	ABC-type enterochelin transport system periplasmic component
C2H94_12485	COG2814	Major facilitator Superfamily
C2H94_12490	COG1309	transcriptional regulator
C2H94_12495	COG0778	Nitroreductase
C2H94_12500	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C2H94_12505	COG0640	Transcriptional regulator
C2H94_12515	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2H94_12520	COG1012	belongs to the aldehyde dehydrogenase family
C2H94_12525	COG4975	Glucose uptake
C2H94_12530	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_12535	COG4549	nuclear export factor GLE1
C2H94_12540	COG1276	copper resistance
C2H94_12540	COG2372	response to copper ion
C2H94_12545	COG1349	DNA-binding transcription factor activity
C2H94_12555	COG2213	PTS system mannitol-specific
C2H94_12560	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H94_12565	COG0246	Mannitol dehydrogenase
C2H94_12570	COG0473	3-isopropylmalate dehydrogenase activity
C2H94_12575	COG0681	Belongs to the peptidase S26 family
C2H94_12580	COG0412	Dienelactone hydrolase
C2H94_12585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2H94_12595	COG0561	phosphatase activity
C2H94_12600	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C2H94_12605	COG1914	H( )-stimulated, divalent metal cation uptake system
C2H94_12610	COG4336	lyase activity
C2H94_12615	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C2H94_12620	COG1984	allophanate hydrolase subunit 2
C2H94_12625	COG1414	Transcriptional regulator
C2H94_12630	COG2755	lipolytic protein G-D-S-L family
C2H94_12640	COG2329	Antibiotic biosynthesis monooxygenase
C2H94_12645	COG0768	penicillin binding
C2H94_12650	COG4989	oxidoreductase activity
C2H94_12655	COG3711	transcriptional antiterminator
C2H94_12660	COG0318	PFAM AMP-dependent synthetase and ligase
C2H94_12665	COG2226	methyltransferase
C2H94_12670	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_12675	COG1917	Cupin 2, conserved barrel domain protein
C2H94_12680	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H94_12685	COG3871	stress protein (general stress protein 26)
C2H94_12695	COG2814	Major facilitator Superfamily
C2H94_12700	COG1522	sequence-specific DNA binding
C2H94_12705	COG0551	DNA topoisomerase type I activity
C2H94_12705	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2H94_12710	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C2H94_12715	COG3706	GGDEF domain
C2H94_12720	COG5298	Protein conserved in bacteria
C2H94_12725	COG1215	transferase activity, transferring glycosyl groups
C2H94_12735	COG0531	amino acid
C2H94_12740	COG0494	nUDIX hydrolase
C2H94_12745	COG0028	Belongs to the TPP enzyme family
C2H94_12755	COG1914	H( )-stimulated, divalent metal cation uptake system
C2H94_12760	COG2261	transglycosylase associated protein
C2H94_12765	COG4876	unkown
C2H94_12770	COG2217	Heavy metal translocating P-type atpase
C2H94_12775	COG3729	General stress protein
C2H94_12780	COG0662	Cupin 2, conserved barrel domain protein
C2H94_12785	COG2329	Antibiotic biosynthesis monooxygenase
C2H94_12790	COG3546	catalase activity
C2H94_12795	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C2H94_12800	COG3290	protein histidine kinase activity
C2H94_12805	COG4565	transcriptional regulatory protein
C2H94_12810	COG1301	dicarboxylic acid transport
C2H94_12815	COG0628	permease
C2H94_12820	COG1131	(ABC) transporter
C2H94_12825	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2H94_12835	COG1960	acyl-CoA dehydrogenase activity
C2H94_12850	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2H94_12855	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H94_12860	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2H94_12865	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2H94_12875	COG0513	Belongs to the DEAD box helicase family
C2H94_12880	COG3402	PFAM membrane-flanked domain
C2H94_12885	COG3428	Bacterial PH domain
C2H94_12890	COG0705	Rhomboid family
C2H94_12895	COG0736	holo-[acyl-carrier-protein] synthase activity
C2H94_12900	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2H94_12905	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2H94_12910	COG0864	Transcriptional regulator
C2H94_12915	COG2337	Toxic component of a toxin-antitoxin (TA) module
C2H94_12920	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H94_12925	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H94_12930	COG2172	sigma factor antagonist activity
C2H94_12935	COG2208	phosphoserine phosphatase activity
C2H94_12940	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H94_12945	COG2172	sigma factor antagonist activity
C2H94_12950	COG1191	sigma factor activity
C2H94_12955	COG2208	phosphoserine phosphatase activity
C2H94_12965	COG1673	EVE domain
C2H94_12970	COG1846	Transcriptional regulator
C2H94_12975	COG2183	response to ionizing radiation
C2H94_12985	COG3091	SprT-like family
C2H94_13035	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2H94_13045	COG3764	Sortase (surface protein transpeptidase)
C2H94_13065	COG0693	protein deglycase activity
C2H94_13070	COG1278	Cold shock
C2H94_13075	COG1329	Transcriptional regulator
C2H94_13090	COG2207	Transcriptional regulator
C2H94_13090	COG1917	Cupin 2, conserved barrel domain protein
C2H94_13095	COG0697	spore germination
C2H94_13100	COG3708	Transcriptional regulator
C2H94_13100	COG2207	Transcriptional regulator
C2H94_13105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H94_13110	COG0477	Major facilitator Superfamily
C2H94_13120	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
C2H94_13135	COG0697	spore germination
C2H94_13140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H94_13145	COG2030	dehydratase
C2H94_13150	COG3545	Serine hydrolase
C2H94_13155	COG1733	regulation of RNA biosynthetic process
C2H94_13160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H94_13165	COG0640	Transcriptional regulator
C2H94_13170	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2H94_13180	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H94_13185	COG1316	TRANSCRIPTIONal
C2H94_13205	COG0745	RESPONSE REGULATOR receiver
C2H94_13210	COG0697	spore germination
C2H94_13215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H94_13220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2H94_13225	COG0640	Transcriptional regulator
C2H94_13230	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2H94_13245	COG4585	Histidine kinase
C2H94_13250	COG2197	response regulator
C2H94_13255	COG2409	Drug exporters of the RND superfamily
C2H94_13260	COG1811	Na channel or pump
C2H94_13265	COG4978	Transcriptional regulator
C2H94_13265	COG0789	Transcriptional regulator
C2H94_13270	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2H94_13275	COG0778	Nitroreductase
C2H94_13280	COG0346	lactoylglutathione lyase activity
C2H94_13285	COG2259	Doxx family
C2H94_13290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H94_13310	COG2323	membrane
C2H94_13315	COG0071	Belongs to the small heat shock protein (HSP20) family
C2H94_13330	COG1309	transcriptional regulator
C2H94_13340	COG0456	acetyltransferase
C2H94_13345	COG0488	(ABC) transporter
C2H94_13350	COG1113	amino acid transport
C2H94_13355	COG2318	DinB family
C2H94_13360	COG1846	Transcriptional regulator
C2H94_13365	COG1033	growth of symbiont in host cell
C2H94_13365	COG2409	Drug exporters of the RND superfamily
C2H94_13370	COG0778	Nitroreductase
C2H94_13375	COG1846	Transcriptional regulator
C2H94_13380	COG2814	Major facilitator Superfamily
C2H94_13385	COG0730	response to heat
C2H94_13390	COG1802	Transcriptional regulator
C2H94_13395	COG3858	chitin binding
C2H94_13395	COG1388	LysM domain
C2H94_13400	COG1819	glycosyl
C2H94_13410	COG1785	Belongs to the alkaline phosphatase family
C2H94_13425	COG0454	-acetyltransferase
C2H94_13430	COG1078	dGTPase activity
C2H94_13435	COG1388	LysM domain
C2H94_13440	COG2814	Major facilitator Superfamily
C2H94_13445	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H94_13450	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2H94_13455	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H94_13460	COG2723	6-phospho-beta-galactosidase activity
C2H94_13465	COG2188	Transcriptional regulator
C2H94_13470	COG1940	carbohydrate kinase activity
C2H94_13475	COG1482	cell wall glycoprotein biosynthetic process
C2H94_13480	COG4124	Belongs to the glycosyl hydrolase 26 family
C2H94_13525	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C2H94_13530	COG0802	atpase or kinase
C2H94_13535	COG1214	PFAM Peptidase M22, glycoprotease
C2H94_13540	COG0456	acetyltransferase
C2H94_13545	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C2H94_13550	COG0488	(ABC) transporter
C2H94_13555	COG0315	cyclic pyranopterin monophosphate synthase activity
C2H94_13560	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C2H94_13565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2H94_13570	COG0805	protein transport
C2H94_13580	COG1266	CAAX protease self-immunity
C2H94_13590	COG0459	protein refolding
C2H94_13600	COG1073	alpha beta
C2H94_13605	COG0457	Tetratricopeptide repeat
C2H94_13610	COG1063	alcohol dehydrogenase
C2H94_13615	COG2211	Major facilitator Superfamily
C2H94_13620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H94_13625	COG1842	Phage shock protein A
C2H94_13630	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2H94_13635	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C2H94_13640	COG4260	virion core protein, lumpy skin disease virus
C2H94_13650	COG2814	Major facilitator Superfamily
C2H94_13655	COG1063	alcohol dehydrogenase
C2H94_13660	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2H94_13665	COG0823	Involved in the tonB-independent uptake of proteins
C2H94_13680	COG2267	carboxylic ester hydrolase activity
C2H94_13690	COG2132	Multicopper oxidase
C2H94_13695	COG1113	amino acid transport
C2H94_13705	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2H94_13710	COG0714	Associated with various cellular activities
C2H94_13715	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
C2H94_13720	COG1305	Transglutaminase-like
C2H94_13725	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2H94_13725	COG0519	Catalyzes the synthesis of GMP from XMP
C2H94_13760	COG2252	PERMEase
C2H94_13765	COG3064	Membrane
C2H94_13775	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
C2H94_13785	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2H94_13790	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2H94_13795	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2H94_13800	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C2H94_13805	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2H94_13810	COG0047	phosphoribosylformylglycinamidine synthase activity
C2H94_13815	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2H94_13820	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2H94_13825	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C2H94_13830	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2H94_13835	COG0138	bifunctional purine biosynthesis protein purh
C2H94_13840	COG0151	Belongs to the GarS family
C2H94_13845	COG1522	sequence-specific DNA binding
C2H94_13850	COG0531	amino acid
C2H94_13860	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C2H94_13865	COG1470	cell adhesion involved in biofilm formation
C2H94_13870	COG4496	protein, YerC YecD
C2H94_13875	COG0069	glutamate synthase activity
C2H94_13880	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
C2H94_13885	COG0210	DNA helicase
C2H94_13890	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2H94_13900	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H94_13905	COG1285	pathogenesis
C2H94_13910	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H94_13915	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2H94_13920	COG0154	amidase activity
C2H94_13925	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2H94_13930	COG1309	transcriptional regulator
C2H94_13935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2H94_13940	COG1597	lipid kinase activity
C2H94_13945	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2H94_13965	COG0457	Tetratricopeptide repeat
C2H94_13980	COG5444	nuclease activity
C2H94_13990	COG3586	endonuclease activity
C2H94_14000	COG0457	Tetratricopeptide repeat
C2H94_14010	COG0217	transcriptional regulatory protein
C2H94_14020	COG1309	transcriptional regulator
C2H94_14025	COG3631	Ketosteroid isomerase-related protein
C2H94_14030	COG0702	epimerase
C2H94_14045	COG3546	catalase activity
C2H94_14050	COG0454	-acetyltransferase
C2H94_14060	COG5578	integral membrane protein
C2H94_14065	COG2972	Histidine kinase
C2H94_14070	COG2207	Transcriptional regulator
C2H94_14070	COG4753	response regulator
C2H94_14075	COG1653	transport
C2H94_14080	COG1175	transmembrane transport
C2H94_14085	COG0395	ABC-type sugar transport system, permease component
C2H94_14090	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2H94_14095	COG2207	Transcriptional regulator
C2H94_14100	COG2755	lipolytic protein G-D-S-L family
C2H94_14110	COG5578	integral membrane protein
C2H94_14115	COG3401	FG-GAP repeat protein
C2H94_14120	COG3401	FG-GAP repeat protein
C2H94_14125	COG2755	lipolytic protein G-D-S-L family
C2H94_14130	COG1874	Beta-galactosidase
C2H94_14140	COG1653	transport
C2H94_14145	COG4209	transmembrane transport
C2H94_14150	COG0395	ABC-type sugar transport system, permease component
C2H94_14155	COG1486	melibiose metabolic process
C2H94_14160	COG2323	membrane
C2H94_14165	COG2329	Antibiotic biosynthesis monooxygenase
C2H94_14170	COG0346	lactoylglutathione lyase activity
C2H94_14185	COG5583	Uncharacterized small protein (DUF2292)
C2H94_14190	COG0670	Belongs to the BI1 family
C2H94_14195	COG0697	spore germination
C2H94_14200	COG1846	Transcriptional regulator
C2H94_14205	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2H94_14220	COG2124	cytochrome p450
C2H94_14220	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2H94_14225	COG1368	sulfuric ester hydrolase activity
C2H94_14230	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2H94_14235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H94_14245	COG1216	Glycosyl transferase, family 2
C2H94_14250	COG1442	glycosyl transferase family 8
C2H94_14255	COG2223	nitrite transmembrane transporter activity
C2H94_14260	COG1011	Hydrolase
C2H94_14265	COG0531	amino acid
C2H94_14270	COG1012	belongs to the aldehyde dehydrogenase family
C2H94_14275	COG0840	transmembrane signaling receptor activity
C2H94_14280	COG0488	(ABC) transporter
C2H94_14290	COG0789	Transcriptional regulator
C2H94_14295	COG2814	Major facilitator Superfamily
C2H94_14300	COG1404	Belongs to the peptidase S8 family
C2H94_14315	COG0488	(ABC) transporter
C2H94_14320	COG0513	Belongs to the DEAD box helicase family
C2H94_14325	COG0456	acetyltransferase
C2H94_14330	COG2130	NADP-dependent
C2H94_14335	COG1120	ATPase activity
C2H94_14340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H94_14345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H94_14350	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C2H94_14370	COG3866	Pectate lyase
C2H94_14375	COG0471	metal ion transport
C2H94_14380	COG3290	protein histidine kinase activity
C2H94_14385	COG4565	transcriptional regulatory protein
C2H94_14390	COG3181	Tripartite tricarboxylate transporter family receptor
C2H94_14395	COG2851	Citrate transporter
C2H94_14400	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H94_14405	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
C2H94_14410	COG1254	Belongs to the acylphosphatase family
C2H94_14415	COG2258	MOSC domain
C2H94_14435	COG0024	Methionine aminopeptidase
C2H94_14440	COG1263	PTS System
C2H94_14440	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H94_14445	COG1368	sulfuric ester hydrolase activity
C2H94_14460	COG1115	amino acid carrier protein
C2H94_14465	COG0531	amino acid
C2H94_14480	COG0697	spore germination
C2H94_14485	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H94_14485	COG1263	PTS System
C2H94_14490	COG0366	Alpha amylase catalytic
C2H94_14495	COG2188	Transcriptional regulator
C2H94_14500	COG0778	Nitroreductase
C2H94_14505	COG0737	Belongs to the 5'-nucleotidase family
C2H94_14510	COG0693	protein deglycase activity
C2H94_14515	COG2814	Major facilitator Superfamily
C2H94_14520	COG4840	Belongs to the UPF0435 family
C2H94_14525	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2H94_14530	COG4980	gas vesicle protein
C2H94_14535	COG1295	ribonuclease BN
C2H94_14540	COG0477	Major facilitator Superfamily
C2H94_14545	COG0387	Pfam Sodium calcium exchanger
C2H94_14555	COG0668	transmembrane transport
C2H94_14560	COG0535	radical SAM domain protein
C2H94_14570	COG0726	polysaccharide deacetylase
C2H94_14575	COG2084	Dehydrogenase
C2H94_14580	COG0598	Magnesium transport protein CorA
C2H94_14585	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2H94_14590	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2H94_14600	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2H94_14605	COG4637	Psort location Cytoplasmic, score
C2H94_14615	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2H94_14620	COG0022	dehydrogenase e1 component
C2H94_14625	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H94_14630	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2H94_14635	COG3284	Transcriptional regulator
C2H94_14645	COG1742	UPF0060 membrane protein
C2H94_14670	COG4842	Belongs to the WXG100 family
C2H94_14675	COG1486	melibiose metabolic process
C2H94_14680	COG1737	Transcriptional regulator
C2H94_14685	COG1263	PTS System
C2H94_14685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H94_14695	COG1132	(ABC) transporter
C2H94_14700	COG1132	(ABC) transporter
C2H94_14705	COG2259	Doxx family
C2H94_14710	COG2514	catechol 2,3-dioxygenase activity
C2H94_14715	COG4585	Histidine kinase
C2H94_14720	COG2197	response regulator
C2H94_14730	COG1131	(ABC) transporter
C2H94_14735	COG1511	domain protein
C2H94_14735	COG0842	Transport permease protein
C2H94_14740	COG0842	Transport permease protein
C2H94_14745	COG1695	Transcriptional regulator
C2H94_14750	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C2H94_14755	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
C2H94_14760	COG2318	DinB family
C2H94_14765	COG2814	Major facilitator Superfamily
C2H94_14770	COG1846	Transcriptional regulator
C2H94_14775	COG0392	lysyltransferase activity
C2H94_14775	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C2H94_14780	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H94_14785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H94_14790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H94_14795	COG0384	phenazine biosynthesis protein PhzF
C2H94_14800	COG0778	Nitroreductase
C2H94_14815	COG1090	epimerase
C2H94_14820	COG2137	regulation of response to DNA damage stimulus
C2H94_14830	COG2814	Major facilitator Superfamily
C2H94_14845	COG3103	Sh3 type 3 domain protein
C2H94_14850	COG5658	integral membrane protein
C2H94_14855	COG0596	Alpha beta hydrolase
C2H94_14860	COG0463	Glycosyl transferase, family 2
C2H94_14865	COG4485	Bacterial membrane protein, YfhO
C2H94_14870	COG1988	membrane-bound metal-dependent
C2H94_14875	COG1194	a g-specific adenine glycosylase
C2H94_14885	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_14900	COG3557	Belongs to the UPF0374 family
C2H94_14905	COG1132	(ABC) transporter
C2H94_14910	COG4129	membrane
C2H94_14915	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2H94_14920	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2H94_14925	COG0735	belongs to the Fur family
C2H94_15035	COG4326	sporulation control protein
C2H94_15045	COG5577	PFAM Coat F domain
C2H94_15050	COG3340	Belongs to the peptidase S51 family
C2H94_15055	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C2H94_15070	COG0753	catalase activity
C2H94_15075	COG1116	anion transmembrane transporter activity
C2H94_15080	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2H94_15085	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2H94_15090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H94_15100	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C2H94_15110	COG1476	TRANSCRIPTIONal
C2H94_15120	COG3382	B3 4 domain protein
C2H94_15125	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2H94_15135	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2H94_15140	COG0789	Transcriptional regulator
C2H94_15145	COG1664	Polymer-forming cytoskeletal
C2H94_15150	COG1664	Polymer-forming cytoskeletal
C2H94_15155	COG2766	serine protein kinase
C2H94_15160	COG2718	Belongs to the UPF0229 family
C2H94_15165	COG1846	Transcriptional regulator
C2H94_15170	COG1566	PFAM secretion protein HlyD family protein
C2H94_15175	COG2814	Major facilitator Superfamily
C2H94_15180	COG0655	NAD(P)H dehydrogenase (quinone) activity
C2H94_15200	COG1725	Transcriptional regulator
C2H94_15205	COG1131	(ABC) transporter
C2H94_15210	COG1131	(ABC) transporter
C2H94_15215	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2H94_15220	COG1278	Cold shock
C2H94_15230	COG1464	Belongs to the NlpA lipoprotein family
C2H94_15235	COG3706	GGDEF domain
C2H94_15240	COG1823	symporter activity
C2H94_15270	COG5577	PFAM Coat F domain
C2H94_15275	COG0737	Belongs to the 5'-nucleotidase family
C2H94_15275	COG1525	nuclease
C2H94_15275	COG4085	toxin activity
C2H94_15280	COG3764	Sortase (surface protein transpeptidase)
C2H94_15285	COG0564	pseudouridine synthase activity
C2H94_15295	COG0517	IMP dehydrogenase activity
C2H94_15300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2H94_15305	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2H94_15305	COG3153	acetyltransferase
C2H94_15315	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2H94_15320	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
C2H94_15325	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2H94_15330	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2H94_15335	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2H94_15340	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2H94_15345	COG2203	Gaf domain
C2H94_15345	COG4585	Histidine kinase
C2H94_15350	COG2197	response regulator
C2H94_15370	COG0791	NLP P60 protein
C2H94_15370	COG1388	LysM domain
C2H94_15375	COG1959	2 iron, 2 sulfur cluster binding
C2H94_15380	COG0668	transmembrane transport
C2H94_15385	COG2719	SpoVR family
C2H94_15390	COG1785	Belongs to the alkaline phosphatase family
C2H94_15395	COG0791	NLP P60 protein
C2H94_15395	COG1388	LysM domain
C2H94_15400	COG0583	DNA-binding transcription factor activity
C2H94_15405	COG0372	Belongs to the citrate synthase family
C2H94_15410	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_15415	COG0531	amino acid
C2H94_15420	COG0733	neurotransmitter:sodium symporter activity
C2H94_15425	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H94_15430	COG0456	acetyltransferase
C2H94_15445	COG1595	DNA-templated transcription, initiation
C2H94_15450	COG0667	Aldo Keto reductase
C2H94_15460	COG1253	flavin adenine dinucleotide binding
C2H94_15465	COG0789	Transcriptional regulator
C2H94_15470	COG0436	Aminotransferase
C2H94_15475	COG1253	flavin adenine dinucleotide binding
C2H94_15480	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2H94_15485	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2H94_15490	COG0584	glycerophosphoryl diester phosphodiesterase
C2H94_15500	COG0668	transmembrane transport
C2H94_15505	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2H94_15510	COG0726	polysaccharide deacetylase
C2H94_15515	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2H94_15520	COG1757	Na H antiporter
C2H94_15525	COG0589	response to stress
C2H94_15535	COG1132	(ABC) transporter
C2H94_15540	COG1132	(ABC) transporter
C2H94_15545	COG0702	epimerase
C2H94_15570	COG0189	ligase activity
C2H94_15575	COG4399	Belongs to the UPF0754 family
C2H94_15580	COG3679	Belongs to the UPF0342 family
C2H94_15585	COG4335	DNA alkylation repair
C2H94_15590	COG0561	phosphatase activity
C2H94_15595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2H94_15600	COG0475	glutathione-regulated potassium exporter activity
C2H94_15605	COG0490	domain, Protein
C2H94_15615	COG1024	Enoyl-CoA hydratase
C2H94_15625	COG4152	abc transporter atp-binding protein
C2H94_15630	COG1668	transmembrane transport
C2H94_15635	COG0420	3'-5' exonuclease activity
C2H94_15640	COG4717	serine-type aminopeptidase activity
C2H94_15645	COG3481	metal-dependent phosphohydrolase, HD sub domain
C2H94_15655	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2H94_15685	COG1846	Transcriptional regulator
C2H94_15690	COG4980	gas vesicle protein
C2H94_15705	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C2H94_15710	COG0537	adenosine 5'-monophosphoramidase activity
C2H94_15715	COG1131	(ABC) transporter
C2H94_15720	COG4473	ABC transporter
C2H94_15730	COG1473	amidohydrolase
C2H94_15735	COG3069	C4-dicarboxylate transmembrane transporter activity
C2H94_15745	COG2329	Antibiotic biosynthesis monooxygenase
C2H94_15750	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2H94_15755	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C2H94_15760	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C2H94_15765	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C2H94_15770	COG1309	transcriptional regulator
C2H94_15775	COG1511	domain protein
C2H94_15780	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2H94_15785	COG4377	Putative membrane peptidase family (DUF2324)
C2H94_15795	COG1363	Peptidase, m42
C2H94_15800	COG4405	Protein conserved in bacteria
C2H94_15805	COG1301	dicarboxylic acid transport
C2H94_15815	COG1234	tRNA 3'-trailer cleavage
C2H94_15820	COG0095	Lipoate-protein ligase
C2H94_15825	COG0702	epimerase
C2H94_15830	COG0318	PFAM AMP-dependent synthetase and ligase
C2H94_15840	COG0501	Belongs to the peptidase M48B family
C2H94_15850	COG0456	acetyltransferase
C2H94_15855	COG0604	alcohol dehydrogenase
C2H94_15860	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C2H94_15865	COG0406	alpha-ribazole phosphatase activity
C2H94_15870	COG0183	Belongs to the thiolase family
C2H94_15875	COG0318	PFAM AMP-dependent synthetase and ligase
C2H94_15880	COG1268	BioY protein
C2H94_15885	COG0840	transmembrane signaling receptor activity
C2H94_15890	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2H94_15890	COG0723	plastoquinol--plastocyanin reductase activity
C2H94_15895	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_15905	COG4903	ComK protein
C2H94_15910	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_15935	COG0398	Pfam SNARE associated Golgi protein
C2H94_15940	COG0681	Belongs to the peptidase S26 family
C2H94_15945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2H94_15950	COG1846	Transcriptional regulator
C2H94_15955	COG0738	Major facilitator superfamily
C2H94_15960	COG0673	inositol 2-dehydrogenase activity
C2H94_15965	COG0561	phosphatase activity
C2H94_15970	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2H94_15975	COG1609	Transcriptional regulator
C2H94_15980	COG3180	Ammonia monooxygenase
C2H94_15985	COG0477	Major facilitator Superfamily
C2H94_15985	COG2814	Major facilitator Superfamily
C2H94_15990	COG4533	DNA binding
C2H94_16000	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
C2H94_16005	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C2H94_16010	COG1074	ATP-dependent DNA helicase activity
C2H94_16015	COG0420	3'-5' exonuclease activity
C2H94_16020	COG0419	ATPase involved in DNA repair
C2H94_16025	COG1403	HNH endonuclease
C2H94_16065	COG5337	Spore coat protein CotH
C2H94_16070	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2H94_16080	COG1404	Belongs to the peptidase S8 family
C2H94_16090	COG0367	asparagine synthase
C2H94_16095	COG2318	DinB family
C2H94_16100	COG1562	ergosterol biosynthetic process
C2H94_16105	COG0534	Mate efflux family protein
C2H94_16110	COG2207	Transcriptional regulator
C2H94_16110	COG1917	Cupin 2, conserved barrel domain protein
C2H94_16120	COG0673	inositol 2-dehydrogenase activity
C2H94_16125	COG2318	DinB family
C2H94_16130	COG1279	arginine transmembrane transporter activity
C2H94_16135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H94_16140	COG1357	PFAM Pentapeptide repeats (8 copies)
C2H94_16145	COG2267	carboxylic ester hydrolase activity
C2H94_16150	COG0529	Catalyzes the synthesis of activated sulfate
C2H94_16155	COG2046	Belongs to the sulfate adenylyltransferase family
C2H94_16160	COG0175	sulfate reduction
C2H94_16165	COG2045	Belongs to the ComB family
C2H94_16170	COG1809	phosphosulfolactate synthase activity
C2H94_16175	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H94_16185	COG2814	Major facilitator Superfamily
C2H94_16190	COG0454	-acetyltransferase
C2H94_16195	COG2153	protein acetylation
C2H94_16200	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C2H94_16200	COG0646	methionine synthase
C2H94_16205	COG1666	GTP binding
C2H94_16210	COG2996	Protein conserved in bacteria
C2H94_16230	COG1695	Transcriptional regulator
C2H94_16245	COG3227	Zinc metalloprotease (Elastase)
C2H94_16250	COG1307	EDD domain protein, DegV family
C2H94_16255	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H94_16270	COG0561	phosphatase activity
C2H94_16275	COG1073	alpha beta
C2H94_16280	COG2151	metal-sulfur cluster biosynthetic enzyme
C2H94_16295	COG2271	Major facilitator Superfamily
C2H94_16300	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2H94_16305	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C2H94_16315	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2H94_16320	COG0505	Belongs to the CarA family
C2H94_16325	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2H94_16330	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2H94_16345	COG2267	carboxylic ester hydrolase activity
C2H94_16355	COG1744	ABC transporter substrate-binding protein PnrA-like
C2H94_16370	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2H94_16375	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2H94_16380	COG5504	Zn-dependent protease
C2H94_16385	COG0444	Belongs to the ABC transporter superfamily
C2H94_16390	COG4608	Belongs to the ABC transporter superfamily
C2H94_16400	COG0601	transmembrane transport
C2H94_16405	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2H94_16415	COG0180	Tryptophanyl-tRNA synthetase
C2H94_16420	COG4166	transmembrane transport
C2H94_16425	COG0601	transmembrane transport
C2H94_16430	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2H94_16435	COG0444	Belongs to the ABC transporter superfamily
C2H94_16440	COG4608	Belongs to the ABC transporter superfamily
C2H94_16445	COG2814	Major facilitator Superfamily
C2H94_16450	COG0456	acetyltransferase
C2H94_16455	COG1393	Belongs to the ArsC family
C2H94_16460	COG0861	Integral membrane protein TerC family
C2H94_16465	COG4862	establishment of competence for transformation
C2H94_16470	COG4469	Competence protein
C2H94_16475	COG1164	Oligoendopeptidase f
C2H94_16490	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C2H94_16495	COG2346	COG2346, Truncated hemoglobins
C2H94_16500	COG0741	lytic transglycosylase activity
C2H94_16505	COG4116	CYTH
C2H94_16515	COG2357	RelA SpoT domain protein
C2H94_16520	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2H94_16525	COG0564	pseudouridine synthase activity
C2H94_16530	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2H94_16535	COG0569	domain protein
C2H94_16535	COG0475	glutathione-regulated potassium exporter activity
C2H94_16540	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2H94_16545	COG0352	thiamine-phosphate diphosphorylase activity
C2H94_16550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2H94_16555	COG2104	thiamine diphosphate biosynthetic process
C2H94_16560	COG2022	thiamine diphosphate biosynthetic process
C2H94_16565	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2H94_16570	COG0351	phosphomethylpyrimidine kinase
C2H94_16575	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2H94_16630	COG0210	DNA helicase
C2H94_16640	COG2153	protein acetylation
C2H94_16645	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2H94_16650	COG2382	esterase
C2H94_16655	COG0626	cystathionine gamma-synthase activity
C2H94_16660	COG0626	cystathionine gamma-synthase activity
C2H94_16665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H94_16670	COG5505	Protein of unknown function (DUF819)
C2H94_16700	COG5444	nuclease activity
C2H94_16730	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C2H94_16740	COG3711	transcriptional antiterminator
C2H94_16740	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H94_16745	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H94_16745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H94_16745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H94_16750	COG1482	cell wall glycoprotein biosynthetic process
C2H94_16760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H94_16770	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2H94_16800	COG0726	polysaccharide deacetylase
C2H94_16820	COG2205	protein histidine kinase activity
C2H94_16830	COG3383	formate dehydrogenase (NAD+) activity
C2H94_16835	COG2427	Protein of unknown function (DUF1641)
C2H94_16845	COG1051	belongs to the nudix hydrolase family
C2H94_16855	COG2124	cytochrome p450
C2H94_16860	COG1819	glycosyl
C2H94_16870	COG1587	Uroporphyrinogen-III synthase
C2H94_16875	COG0390	transport system, permease component
C2H94_16880	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2H94_16885	COG0697	spore germination
C2H94_16890	COG4297	protein containing double-stranded beta helix domain
C2H94_16900	COG1252	NADH dehydrogenase
C2H94_16905	COG1904	glucuronate isomerase
C2H94_16910	COG2211	Major facilitator Superfamily
C2H94_16915	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C2H94_16920	COG1063	alcohol dehydrogenase
C2H94_16925	COG1312	Catalyzes the dehydration of D-mannonate
C2H94_16930	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_16935	COG2271	Major facilitator Superfamily
C2H94_16940	COG1609	Transcriptional regulator
C2H94_16945	COG0246	Mannitol dehydrogenase
C2H94_16950	COG2721	sulfolactate sulfo-lyase activity
C2H94_16955	COG0730	response to heat
C2H94_16960	COG2318	DinB family
C2H94_16965	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2H94_16970	COG0457	Tetratricopeptide repeat
C2H94_16980	COG2350	Protein conserved in bacteria
C2H94_16985	COG1388	LysM domain
C2H94_16985	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2H94_16985	COG3409	Peptidoglycan-binding domain 1 protein
C2H94_16995	COG4195	phage-related replication protein
C2H94_17000	COG3546	catalase activity
C2H94_17005	COG2856	Zn peptidase
C2H94_17010	COG1396	sequence-specific DNA binding
C2H94_17020	COG1522	sequence-specific DNA binding
C2H94_17025	COG1484	DNA-dependent DNA replication
C2H94_17045	COG1595	DNA-templated transcription, initiation
C2H94_17050	COG3728	DNA packaging
C2H94_17050	COG5484	DNA packaging
C2H94_17055	COG1783	phage Terminase large subunit
C2H94_17060	COG5518	Phage portal protein
C2H94_17065	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C2H94_17070	COG4653	Phage capsid family
C2H94_17120	COG3953	SLT domain
C2H94_17120	COG3953	SLT domain
C2H94_17120	COG5412	phage tail tape measure protein
C2H94_17120	COG5412	phage tail tape measure protein
C2H94_17125	COG1652	LysM domain
C2H94_17130	COG4193	domain, Protein
C2H94_17140	COG3628	GPW Gp25 family protein
C2H94_17145	COG3299	homolog of phage Mu protein gp47
C2H94_17150	COG3778	Protein conserved in bacteria
C2H94_17190	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2H94_17190	COG3409	Peptidoglycan-binding domain 1 protein
C2H94_17205	COG0306	phosphate transporter
C2H94_17210	COG1392	Phosphate transport regulator
C2H94_17215	COG0531	amino acid
C2H94_17220	COG0346	lactoylglutathione lyase activity
C2H94_17225	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2H94_17230	COG0463	Glycosyl transferase, family 2
C2H94_17245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H94_17250	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2H94_17255	COG2362	D-Aminopeptidase
C2H94_17260	COG0601	transmembrane transport
C2H94_17270	COG0444	Belongs to the ABC transporter superfamily
C2H94_17275	COG4166	transmembrane transport
C2H94_17280	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2H94_17285	COG4948	Mandelate Racemase Muconate Lactonizing
C2H94_17290	COG0791	NLP P60 protein
C2H94_17295	COG4608	Belongs to the ABC transporter superfamily
C2H94_17300	COG2706	6-phosphogluconolactonase activity
C2H94_17305	COG1834	amidinotransferase
C2H94_17310	COG1607	acyl-coa hydrolase
C2H94_17315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2H94_17315	COG1017	nitric oxide dioxygenase activity
C2H94_17325	COG2323	membrane
C2H94_17330	COG2318	DinB family
C2H94_17335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H94_17340	COG2076	Multidrug Resistance protein
C2H94_17345	COG2076	Multidrug Resistance protein
C2H94_17350	COG0788	formyltetrahydrofolate deformylase activity
C2H94_17355	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C2H94_17360	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C2H94_17365	COG1764	response to oxidative stress
C2H94_17370	COG1846	Transcriptional regulator
C2H94_17375	COG1764	response to oxidative stress
C2H94_17380	COG0590	tRNA wobble adenosine to inosine editing
C2H94_17385	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2H94_17390	COG1404	Belongs to the peptidase S8 family
C2H94_17395	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H94_17400	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C2H94_17405	COG1122	ATPase activity
C2H94_17410	COG4721	ABC-type cobalt transport system, permease component
C2H94_17420	COG0745	RESPONSE REGULATOR receiver
C2H94_17425	COG5002	protein histidine kinase activity
C2H94_17425	COG3850	Histidine kinase
C2H94_17430	COG3212	peptidase
C2H94_17435	COG3212	peptidase
C2H94_17450	COG2239	Acts as a magnesium transporter
C2H94_17455	COG0789	Transcriptional regulator
C2H94_17470	COG1846	Transcriptional regulator
C2H94_17475	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2H94_17480	COG0726	polysaccharide deacetylase
C2H94_17485	COG1408	metallophosphoesterase
C2H94_17495	COG0463	Glycosyl transferase, family 2
C2H94_17500	COG3285	dna ligase
C2H94_17500	COG1793	dna ligase
C2H94_17505	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C2H94_17510	COG5001	Diguanylate cyclase
C2H94_17510	COG3300	MHYT domain
C2H94_17515	COG0586	Pfam SNARE associated Golgi protein
C2H94_17520	COG0861	Integral membrane protein TerC family
C2H94_17525	COG1191	sigma factor activity
C2H94_17545	COG0501	Belongs to the peptidase M48B family
C2H94_17550	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2H94_17565	COG3594	Acyltransferase
C2H94_17570	COG5002	protein histidine kinase activity
C2H94_17575	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2H94_17580	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C2H94_17585	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
C2H94_17590	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2H94_17595	COG0436	Aminotransferase
C2H94_17600	COG1850	ribulose-bisphosphate carboxylase activity
C2H94_17605	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
C2H94_17610	COG0235	Class ii aldolase
C2H94_17615	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C2H94_17620	COG3339	Conserved Protein
C2H94_17635	COG3852	Histidine kinase
C2H94_17640	COG1846	Transcriptional regulator
C2H94_17645	COG1360	Flagellar Motor Protein
C2H94_17650	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2H94_17655	COG0542	response to heat
C2H94_17660	COG3949	Membrane
C2H94_17665	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C2H94_17670	COG0720	synthase
C2H94_17675	COG0602	queuosine metabolic process
C2H94_17680	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2H94_17685	COG1733	regulation of RNA biosynthetic process
C2H94_17690	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_17695	COG4641	Protein conserved in bacteria
C2H94_17695	COG1388	LysM domain
C2H94_17700	COG1388	LysM domain
C2H94_17705	COG3858	chitin binding
C2H94_17715	COG4873	Protein conserved in bacteria
C2H94_17725	COG3773	Cell wall hydrolase
C2H94_17730	COG2244	polysaccharide biosynthetic process
C2H94_17735	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H94_17740	COG2217	Heavy metal translocating P-type atpase
C2H94_17750	COG0006	proline dipeptidase activity
C2H94_17755	COG1609	Transcriptional regulator
C2H94_17760	COG3711	transcriptional antiterminator
C2H94_17765	COG1263	PTS System
C2H94_17765	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H94_17765	COG2190	(PTS) system
C2H94_17770	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H94_17775	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2H94_17785	COG1533	DNA photolyase activity
C2H94_17795	COG0840	transmembrane signaling receptor activity
C2H94_17800	COG2084	Dehydrogenase
C2H94_17805	COG4257	antibiotic catabolic process
C2H94_17810	COG2340	Cysteine-rich secretory protein family
C2H94_17815	COG0768	penicillin binding
C2H94_17820	COG4191	Histidine kinase
C2H94_17825	COG0436	Aminotransferase
C2H94_17835	COG0784	Response regulator, receiver
C2H94_17835	COG0835	chemotaxis
C2H94_17845	COG2814	Major facilitator Superfamily
C2H94_17850	COG1376	ErfK ybiS ycfS ynhG family protein
C2H94_17855	COG1408	metallophosphoesterase
C2H94_17860	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_17865	COG2200	EAL domain
C2H94_17870	COG4703	Protein of unknown function (DUF1797)
C2H94_17875	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
C2H94_17885	COG0517	IMP dehydrogenase activity
C2H94_17890	COG0583	DNA-binding transcription factor activity
C2H94_17895	COG0716	FMN binding
C2H94_17905	COG0716	FMN binding
C2H94_17910	COG2171	N-acyltransferase activity
C2H94_17915	COG1473	amidohydrolase
C2H94_17925	COG0668	transmembrane transport
C2H94_17930	COG0450	alkyl hydroperoxide reductase
C2H94_17935	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H94_17950	COG0746	molybdenum cofactor guanylyltransferase activity
C2H94_17955	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2H94_17960	COG0303	'Molybdopterin
C2H94_17965	COG1763	Mo-molybdopterin cofactor biosynthetic process
C2H94_17970	COG0314	molybdopterin synthase activity
C2H94_17975	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C2H94_17980	COG1132	(ABC) transporter
C2H94_17985	COG1132	(ABC) transporter
C2H94_17995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2H94_18000	COG1136	(ABC) transporter
C2H94_18005	COG0577	efflux transmembrane transporter activity
C2H94_18010	COG1349	DNA-binding transcription factor activity
C2H94_18015	COG1105	Belongs to the carbohydrate kinase PfkB family
C2H94_18020	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H94_18020	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H94_18020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H94_18025	COG0681	Belongs to the peptidase S26 family
C2H94_18035	COG0488	(ABC) transporter
C2H94_18040	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2H94_18045	COG2309	aminopeptidase activity
C2H94_18055	COG1077	Cell shape determining protein MreB Mrl
C2H94_18060	COG2002	toxin-antitoxin pair type II binding
C2H94_18065	COG3852	Histidine kinase
C2H94_18070	COG2105	PFAM AIG2 family protein
C2H94_18070	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C2H94_18075	COG0569	domain protein
C2H94_18080	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C2H94_18085	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2H94_18090	COG5503	Protein of unknown function (DUF1447)
C2H94_18095	COG0561	phosphatase activity
C2H94_18100	COG0242	peptide deformylase activity
C2H94_18110	COG0497	DNA recombination
C2H94_18115	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2H94_18120	COG0022	dehydrogenase e1 component
C2H94_18125	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H94_18130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2H94_18135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H94_18145	COG1982	Orn Lys Arg decarboxylase major
C2H94_18150	COG4476	Belongs to the UPF0223 family
C2H94_18155	COG4493	Belongs to the UPF0637 family
C2H94_18165	COG0483	inositol monophosphate 1-phosphatase activity
C2H94_18175	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C2H94_18195	COG1595	DNA-templated transcription, initiation
C2H94_18215	COG1217	gtp-binding protein TYPA
C2H94_18225	COG4896	Protein conserved in bacteria
C2H94_18235	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C2H94_18240	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2H94_18245	COG2066	Belongs to the glutaminase family
C2H94_18250	COG4838	Belongs to the UPF0358 family
C2H94_18255	COG0772	Belongs to the SEDS family
C2H94_18260	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C2H94_18265	COG1612	heme a metabolic process
C2H94_18270	COG0109	protoheme IX farnesyltransferase activity
C2H94_18275	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2H94_18275	COG2010	Cytochrome c
C2H94_18280	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2H94_18285	COG1845	cytochrome c oxidase, subunit III
C2H94_18290	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2H94_18295	COG3336	cytochrome c oxidase
C2H94_18305	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C2H94_18310	COG2340	Cysteine-rich secretory protein family
C2H94_18325	COG3679	Belongs to the UPF0342 family
C2H94_18330	COG4471	UPF0298 protein
C2H94_18335	COG0742	ribosomal rna small subunit methyltransferase
C2H94_18340	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C2H94_18345	COG3314	Sporulation integral membrane protein YlbJ
C2H94_18350	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2H94_18355	COG3480	Lon protease (S16) C-terminal proteolytic domain
C2H94_18360	COG1323	Belongs to the UPF0348 family
C2H94_18370	COG1399	metal-binding, possibly nucleic acid-binding protein
C2H94_18385	COG0454	-acetyltransferase
C2H94_18390	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2H94_18395	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
C2H94_18400	COG2001	Belongs to the MraZ family
C2H94_18405	COG0275	rRNA processing
C2H94_18410	COG4839	cell division protein FtsL
C2H94_18415	COG0768	penicillin binding
C2H94_18420	COG0768	penicillin binding
C2H94_18425	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2H94_18430	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2H94_18435	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2H94_18440	COG0772	Belongs to the SEDS family
C2H94_18445	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2H94_18450	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C2H94_18455	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C2H94_18460	COG3879	Bacterial protein of unknown function (DUF881)
C2H94_18465	COG3879	Bacterial protein of unknown function (DUF881)
C2H94_18470	COG3856	small basic protein
C2H94_18475	COG0849	cell division
C2H94_18480	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2H94_18485	COG4412	M6 family metalloprotease domain protein
C2H94_18485	COG1404	Belongs to the peptidase S8 family
C2H94_18495	COG1191	sigma factor activity
C2H94_18500	COG1191	sigma factor activity
C2H94_18505	COG1119	ATPase activity
C2H94_18510	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2H94_18515	COG1873	PFAM PRC-barrel domain
C2H94_18520	COG1496	oxidoreductase activity
C2H94_18525	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2H94_18530	COG1799	cell septum assembly
C2H94_18535	COG0762	integral membrane protein
C2H94_18540	COG2302	S4 RNA-binding domain
C2H94_18545	COG3599	regulation of cell shape
C2H94_18550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2H94_18555	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2H94_18560	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C2H94_18565	COG0564	pseudouridine synthase activity
C2H94_18570	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C2H94_18575	COG2233	PERMEase
C2H94_18580	COG0540	Belongs to the ATCase OTCase family
C2H94_18585	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2H94_18590	COG0505	Belongs to the CarA family
C2H94_18595	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2H94_18600	COG0543	2 iron, 2 sulfur cluster binding
C2H94_18605	COG0167	dihydroorotate dehydrogenase activity
C2H94_18610	COG0284	orotidine-5'-phosphate decarboxylase activity
C2H94_18615	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C2H94_18620	COG0175	sulfate reduction
C2H94_18625	COG0306	phosphate transporter
C2H94_18630	COG2046	Belongs to the sulfate adenylyltransferase family
C2H94_18635	COG0529	Catalyzes the synthesis of activated sulfate
C2H94_18640	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2H94_18645	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
C2H94_18650	COG1648	precorrin-2 dehydrogenase activity
C2H94_18655	COG1293	RNA-binding protein homologous to eukaryotic snRNP
C2H94_18660	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C2H94_18665	COG1561	YicC-like family, N-terminal region
C2H94_18675	COG0194	GDP metabolic process
C2H94_18680	COG1758	RNA polymerase activity
C2H94_18685	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2H94_18690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2H94_18695	COG0242	peptide deformylase activity
C2H94_18700	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2H94_18705	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2H94_18705	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2H94_18710	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C2H94_18715	COG0631	protein serine/threonine phosphatase activity
C2H94_18720	COG2815	serine threonine protein kinase
C2H94_18720	COG0515	serine threonine protein kinase
C2H94_18725	COG1162	GTPase activity
C2H94_18730	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2H94_18735	COG1564	THIamine pyrophosphokinase
C2H94_18745	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C2H94_18750	COG1302	Protein conserved in bacteria
C2H94_18755	COG1461	Dihydroxyacetone kinase
C2H94_18760	COG1760	l-serine dehydratase
C2H94_18765	COG1760	l-serine dehydratase
C2H94_18770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2H94_18775	COG2050	protein possibly involved in aromatic compounds catabolism
C2H94_18775	COG1349	DNA-binding transcription factor activity
C2H94_18780	COG0416	fatty acid biosynthetic process
C2H94_18785	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2H94_18790	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_18800	COG0571	ribonuclease III activity
C2H94_18805	COG1196	nuclear chromosome segregation
C2H94_18810	COG0552	protein localization to endoplasmic reticulum
C2H94_18820	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C2H94_18825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2H94_18830	COG0228	four-way junction DNA binding
C2H94_18835	COG1837	Belongs to the UPF0109 family
C2H94_18845	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2H94_18850	COG0336	Belongs to the RNA methyltransferase TrmD family
C2H94_18855	COG0335	large ribosomal subunit rRNA binding
C2H94_18860	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2H94_18865	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2H94_18875	COG2257	FlhB HrpN YscU SpaS Family
C2H94_18880	COG0045	succinate-CoA ligase (ADP-forming) activity
C2H94_18885	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2H94_18890	COG0758	DNA mediated transformation
C2H94_18895	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2H94_18900	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C2H94_18905	COG4974	Belongs to the 'phage' integrase family
C2H94_18910	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C2H94_18915	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C2H94_18920	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C2H94_18925	COG1815	bacterial-type flagellum-dependent cell motility
C2H94_18930	COG1558	bacterial-type flagellum-dependent cell motility
C2H94_18935	COG1677	Flagellar hook-basal body complex protein FliE
C2H94_18940	COG1766	The M ring may be actively involved in energy transduction
C2H94_18945	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2H94_18950	COG1317	bacterial-type flagellum organization
C2H94_18955	COG1157	protein secretion by the type III secretion system
C2H94_18960	COG2882	bacterial-type flagellum organization
C2H94_18970	COG3144	bacterial-type flagellum assembly
C2H94_18975	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C2H94_18980	COG4786	Flagellar basal body rod
C2H94_18985	COG1582	Flagellar protein (FlbD)
C2H94_18990	COG1580	Controls the rotational direction of flagella during chemotaxis
C2H94_18995	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2H94_19000	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2H94_19000	COG1776	CheC inhibitor of MCP methylation
C2H94_19005	COG2201	protein-glutamate methylesterase activity
C2H94_19010	COG3190	flagellar
C2H94_19015	COG1338	Plays a role in the flagellum-specific transport system
C2H94_19020	COG1987	bacterial-type flagellum assembly
C2H94_19025	COG1684	flagellar biosynthetic protein fliR
C2H94_19030	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2H94_19035	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2H94_19040	COG1419	protein localization to endoplasmic reticulum
C2H94_19045	COG0455	bacterial-type flagellum organization
C2H94_19050	COG2201	protein-glutamate methylesterase activity
C2H94_19055	COG0643	Histidine kinase
C2H94_19055	COG2198	Histidine kinase
C2H94_19060	COG0835	chemotaxis
C2H94_19065	COG1776	CheC inhibitor of MCP methylation
C2H94_19070	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C2H94_19075	COG1191	sigma factor activity
C2H94_19085	COG0052	Belongs to the universal ribosomal protein uS2 family
C2H94_19090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C2H94_19095	COG0528	UMP kinase activity
C2H94_19100	COG0233	cytoplasmic translational termination
C2H94_19105	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C2H94_19110	COG4589	Belongs to the CDS family
C2H94_19115	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2H94_19120	COG0750	zinc metalloprotease
C2H94_19125	COG0442	prolyl-tRNA aminoacylation
C2H94_19130	COG2176	DNA-directed DNA polymerase activity
C2H94_19135	COG0779	Required for maturation of 30S ribosomal subunits
C2H94_19140	COG0195	Participates in both transcription termination and antitermination
C2H94_19145	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C2H94_19150	COG1358	cellular component organization or biogenesis
C2H94_19160	COG1550	Protein conserved in bacteria
C2H94_19165	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C2H94_19170	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C2H94_19175	COG0196	riboflavin kinase activity
C2H94_19180	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C2H94_19185	COG1185	polyribonucleotide nucleotidyltransferase activity
C2H94_19190	COG0726	polysaccharide deacetylase
C2H94_19195	COG0612	Peptidase, M16
C2H94_19200	COG1873	PFAM PRC-barrel domain
C2H94_19205	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2H94_19210	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2H94_19215	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2H94_19220	COG0527	aspartate kinase activity
C2H94_19225	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2H94_19230	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2H94_19235	COG0740	serine-type endopeptidase activity
C2H94_19245	COG4980	gas vesicle protein
C2H94_19245	COG1674	ftsk spoiiie
C2H94_19250	COG2188	Transcriptional regulator
C2H94_19255	COG2814	Major facilitator Superfamily
C2H94_19260	COG0612	Peptidase, M16
C2H94_19265	COG0612	Peptidase, M16
C2H94_19270	COG0300	oxidoreductase activity
C2H94_19285	COG1426	Protein conserved in bacteria
C2H94_19290	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2H94_19295	COG1058	Belongs to the CinA family
C2H94_19295	COG1546	Belongs to the CinA family
C2H94_19300	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C2H94_19305	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2H94_19310	COG1418	mRNA catabolic process
C2H94_19315	COG1692	metallophosphoesterase
C2H94_19320	COG2359	stage V sporulation protein S
C2H94_19325	COG1063	alcohol dehydrogenase
C2H94_19330	COG0156	8-amino-7-oxononanoate synthase activity
C2H94_19335	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2H94_19340	COG4550	Control of competence regulator ComK, YlbF/YmcA
C2H94_19350	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C2H94_19355	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2H94_19370	COG3226	Transcriptional regulator
C2H94_19375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H94_19385	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2H94_19390	COG3321	synthase
C2H94_19400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H94_19405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2H94_19410	COG3425	synthase
C2H94_19415	COG1024	Enoyl-CoA hydratase
C2H94_19420	COG1024	Enoyl-CoA hydratase
C2H94_19425	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_19425	COG3321	synthase
C2H94_19425	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H94_19425	COG0318	PFAM AMP-dependent synthetase and ligase
C2H94_19425	COG0300	oxidoreductase activity
C2H94_19430	COG4221	oxidoreductase activity
C2H94_19430	COG0300	oxidoreductase activity
C2H94_19430	COG3321	synthase
C2H94_19430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H94_19435	COG3321	synthase
C2H94_19435	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_19435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H94_19435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H94_19435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H94_19440	COG1028	Short-chain dehydrogenase reductase Sdr
C2H94_19440	COG3321	synthase
C2H94_19440	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H94_19440	COG4221	oxidoreductase activity
C2H94_19445	COG3321	synthase
C2H94_19445	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C2H94_19445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2H94_19445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H94_19450	COG2124	cytochrome p450
C2H94_19460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H94_19465	COG1404	Belongs to the peptidase S8 family
C2H94_19475	COG4195	phage-related replication protein
C2H94_19480	COG1764	response to oxidative stress
C2H94_19485	COG2076	Multidrug Resistance protein
C2H94_19490	COG2076	Multidrug Resistance protein
C2H94_19505	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C2H94_19510	COG1923	regulation of RNA biosynthetic process
C2H94_19525	COG1780	Probably involved in ribonucleotide reductase function
C2H94_19530	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2H94_19535	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2H94_19540	COG4112	unkown
C2H94_19545	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H94_19555	COG0464	growth
C2H94_19560	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2H94_19565	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
C2H94_19570	COG0789	Transcriptional regulator
C2H94_19575	COG0174	glutamine synthetase
C2H94_19580	COG4974	Belongs to the 'phage' integrase family
C2H94_19590	COG1396	sequence-specific DNA binding
C2H94_19595	COG1396	sequence-specific DNA binding
C2H94_19595	COG1917	Cupin 2, conserved barrel domain protein
C2H94_19665	COG0582	viral genome integration into host DNA
C2H94_19760	COG3953	SLT domain
C2H94_19760	COG5280	Phage tail tape measure protein TP901
C2H94_19770	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2H94_19800	COG4824	toxin secretion phage lysis holin
C2H94_19805	COG3409	Peptidoglycan-binding domain 1 protein
C2H94_19805	COG1388	LysM domain
C2H94_19805	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2H94_19815	COG5444	nuclease activity
C2H94_19845	COG4282	regulation of fungal-type cell wall biogenesis
C2H94_19855	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H94_19890	COG2211	Major facilitator Superfamily
C2H94_19895	COG3507	Belongs to the glycosyl hydrolase 43 family
C2H94_19900	COG1940	carbohydrate kinase activity
C2H94_19905	COG2115	Belongs to the xylose isomerase family
C2H94_19910	COG1070	Carbohydrate kinase
C2H94_19920	COG1525	nuclease
C2H94_19925	COG2814	Major facilitator Superfamily
C2H94_19930	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2H94_19940	COG0756	dUTP diphosphatase activity
C2H94_19975	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2H94_19985	COG3832	glyoxalase III activity
C2H94_19995	COG0697	spore germination
C2H94_20000	COG0531	amino acid
C2H94_20030	COG4195	phage-related replication protein
C2H94_20040	COG0346	lactoylglutathione lyase activity
C2H94_20050	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2H94_20055	COG1388	LysM domain
C2H94_20060	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2H94_20065	COG4224	UPF0291 protein
C2H94_20070	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2H94_20080	COG3763	UPF0154 protein
C2H94_20090	COG0785	Cytochrome C biogenesis protein
C2H94_20095	COG2201	protein-glutamate methylesterase activity
C2H94_20100	COG4846	Membrane protein involved in cytochrome C biogenesis
C2H94_20110	COG0071	Belongs to the small heat shock protein (HSP20) family
C2H94_20125	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2H94_20130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H94_20150	COG0824	Thioesterase
C2H94_20160	COG4841	protein insertion into membrane
C2H94_20165	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C2H94_20170	COG1832	CoA-binding protein
C2H94_20175	COG0187	DNA topoisomerase II activity
C2H94_20180	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2H94_20190	COG1115	amino acid carrier protein
C2H94_20195	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C2H94_20205	COG5520	Belongs to the glycosyl hydrolase 30 family
C2H94_20210	COG3507	Belongs to the glycosyl hydrolase 43 family
C2H94_20215	COG2246	polysaccharide biosynthetic process
C2H94_20220	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2H94_20225	COG0586	Pfam SNARE associated Golgi protein
C2H94_20230	COG2404	hydrolase activity, acting on ester bonds
C2H94_20235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2H94_20240	COG1024	Enoyl-CoA hydratase
C2H94_20245	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2H94_20250	COG0511	ligase activity, forming carbon-carbon bonds
C2H94_20255	COG0439	Biotin carboxylase
C2H94_20260	COG0318	PFAM AMP-dependent synthetase and ligase
C2H94_20265	COG1960	acyl-CoA dehydrogenase activity
C2H94_20270	COG1649	PFAM Uncharacterised BCR, COG1649
C2H94_20280	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C2H94_20280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H94_20285	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H94_20290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H94_20295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H94_20300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H94_20305	COG2027	D-alanyl-D-alanine carboxypeptidase
C2H94_20310	COG2017	converts alpha-aldose to the beta-anomer
C2H94_20315	COG0534	Mate efflux family protein
C2H94_20330	COG0582	viral genome integration into host DNA
C2H94_20335	COG0166	Belongs to the GPI family
C2H94_20340	COG0405	Gamma-glutamyltransferase
C2H94_20345	COG0583	DNA-binding transcription factor activity
C2H94_20350	COG0604	alcohol dehydrogenase
C2H94_20355	COG0493	'glutamate synthase
C2H94_20360	COG0070	glutamate synthase
C2H94_20360	COG0067	glutamate synthase
C2H94_20360	COG0069	glutamate synthase activity
C2H94_20365	COG0583	DNA-binding transcription factor activity
C2H94_20370	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C2H94_20375	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2H94_20385	COG0300	oxidoreductase activity
C2H94_20390	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
C2H94_20400	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H94_20415	COG1131	(ABC) transporter
C2H94_20425	COG2814	Major facilitator Superfamily
C2H94_20435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2H94_20440	COG0243	molybdopterin cofactor binding
C2H94_20450	COG2814	Major facilitator Superfamily
C2H94_20455	COG0673	inositol 2-dehydrogenase activity
C2H94_20460	COG1082	Xylose isomerase domain protein TIM barrel
C2H94_20465	COG1609	Transcriptional regulator
C2H94_20485	COG5278	phosphoserine phosphatase activity
C2H94_20485	COG0840	transmembrane signaling receptor activity
C2H94_20490	COG2368	4-hydroxyphenylacetate
C2H94_20495	COG4305	rare lipoprotein A
C2H94_20500	COG3619	membrane
C2H94_20505	COG3866	Pectate lyase
C2H94_20510	COG2135	peptidase activity
C2H94_20520	COG2140	Oxalate decarboxylase
C2H94_20540	COG2720	vancomycin resistance protein
C2H94_20550	COG3655	Transcriptional regulator
C2H94_20555	COG3739	integral membrane protein
C2H94_20560	COG0583	DNA-binding transcription factor activity
C2H94_20565	COG0697	spore germination
C2H94_20575	COG0693	protein deglycase activity
C2H94_20580	COG2367	Beta-lactamase
C2H94_20600	COG0574	Belongs to the PEP-utilizing enzyme family
C2H94_20600	COG3848	Pyruvate phosphate dikinase
C2H94_20605	COG0726	polysaccharide deacetylase
C2H94_20615	COG2314	TM2 domain
C2H94_20645	COG3655	Transcriptional regulator
C2H94_20680	COG0457	Tetratricopeptide repeat
C2H94_20690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2H94_20700	COG4282	regulation of fungal-type cell wall biogenesis
C2H94_20705	COG1231	oxidoreductase activity
C2H94_20710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H94_20715	COG2207	Transcriptional regulator
C2H94_20715	COG0662	Cupin 2, conserved barrel domain protein
C2H94_20720	COG0456	acetyltransferase
C2H94_20725	COG1309	transcriptional regulator
C2H94_20730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H94_20735	COG3708	Transcriptional regulator
C2H94_20740	COG2378	regulation of single-species biofilm formation
C2H94_20750	COG0640	Transcriptional regulator
C2H94_20755	COG0741	lytic transglycosylase activity
C2H94_20760	COG2322	membrane
C2H94_20775	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2H94_20780	COG3239	Fatty acid desaturase
C2H94_20785	COG4585	Histidine kinase
C2H94_20790	COG2197	response regulator
C2H94_20795	COG1388	LysM domain
C2H94_20795	COG3584	3D domain protein
C2H94_20800	COG0514	ATP-dependent DNA helicase (RecQ)
C2H94_20815	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2H94_20820	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2H94_20835	COG0071	Belongs to the small heat shock protein (HSP20) family
C2H94_20860	COG1012	belongs to the aldehyde dehydrogenase family
C2H94_20865	COG1657	PFAM Prenyltransferase squalene oxidase
C2H94_20870	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2H94_20875	COG0733	neurotransmitter:sodium symporter activity
C2H94_20880	COG0385	Bile acid
C2H94_20885	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H94_20890	COG0567	Dehydrogenase, E1 component
C2H94_20895	COG4548	von Willebrand factor, type A
C2H94_20900	COG0714	Associated with various cellular activities
C2H94_20905	COG2032	superoxide dismutase activity
C2H94_20910	COG1388	LysM domain
C2H94_20910	COG0791	NLP P60 protein
C2H94_20915	COG1819	glycosyl
C2H94_20920	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C2H94_20925	COG0534	Mate efflux family protein
C2H94_20930	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H94_20935	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2H94_20940	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2H94_20950	COG2962	Rard protein
C2H94_20965	COG2610	gluconate transmembrane transporter activity
C2H94_20970	COG1942	4-Oxalocrotonate Tautomerase
C2H94_20975	COG1733	regulation of RNA biosynthetic process
C2H94_20980	COG0778	Nitroreductase