locus-tag	class	description
C2H96_00005	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
C2H96_00010	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2H96_00015	COG2233	PERMEase
C2H96_00020	COG3424	synthase
C2H96_00025	COG1755	Isoprenylcysteine carboxyl methyltransferase
C2H96_00035	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2H96_00050	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2H96_00060	COG0328	RNA-DNA hybrid ribonuclease activity
C2H96_00065	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C2H96_00070	COG0328	RNA-DNA hybrid ribonuclease activity
C2H96_00090	COG1278	Cold shock
C2H96_00095	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2H96_00100	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
C2H96_00105	COG0386	Belongs to the glutathione peroxidase family
C2H96_00110	COG1418	mRNA catabolic process
C2H96_00115	COG1413	lyase activity
C2H96_00120	COG0129	dihydroxy-acid dehydratase activity
C2H96_00130	COG2136	Putative SAM-dependent methyltransferase
C2H96_00130	COG2521	methyltransferase
C2H96_00140	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2H96_00145	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2H96_00150	COG0204	Acyl-transferase
C2H96_00155	COG1272	protein, Hemolysin III
C2H96_00160	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2H96_00165	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C2H96_00175	COG1999	signal sequence binding
C2H96_00180	COG2755	lipolytic protein G-D-S-L family
C2H96_00185	COG4698	Protein conserved in bacteria
C2H96_00195	COG0534	Mate efflux family protein
C2H96_00200	COG1846	Transcriptional regulator
C2H96_00205	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2H96_00210	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C2H96_00215	COG1086	Polysaccharide biosynthesis protein
C2H96_00220	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
C2H96_00225	COG4641	Protein conserved in bacteria
C2H96_00240	COG0463	Glycosyl transferase, family 2
C2H96_00245	COG0456	acetyltransferase
C2H96_00255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2H96_00260	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2H96_00265	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2H96_00270	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2H96_00275	COG0456	acetyltransferase
C2H96_00280	COG1509	lysine 2,3-aminomutase activity
C2H96_00340	COG4479	Belongs to the UPF0346 family
C2H96_00365	COG0671	phosphoesterase, PA-phosphatase related
C2H96_00380	COG0813	purine-nucleoside phosphorylase activity
C2H96_00385	COG1876	peptidase activity
C2H96_00395	COG2226	methyltransferase
C2H96_00400	COG0793	Belongs to the peptidase S41A family
C2H96_00400	COG3409	Peptidoglycan-binding domain 1 protein
C2H96_00405	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H96_00415	COG0346	lactoylglutathione lyase activity
C2H96_00420	COG0400	carboxylic ester hydrolase activity
C2H96_00425	COG0778	Nitroreductase
C2H96_00430	COG1733	regulation of RNA biosynthetic process
C2H96_00435	COG1942	4-Oxalocrotonate Tautomerase
C2H96_00440	COG2610	gluconate transmembrane transporter activity
C2H96_00455	COG2962	Rard protein
C2H96_00465	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2H96_00470	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2H96_00475	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H96_00480	COG0534	Mate efflux family protein
C2H96_00485	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C2H96_00490	COG1819	glycosyl
C2H96_00495	COG0791	NLP P60 protein
C2H96_00495	COG1388	LysM domain
C2H96_00500	COG2032	superoxide dismutase activity
C2H96_00505	COG0714	Associated with various cellular activities
C2H96_00510	COG4548	von Willebrand factor, type A
C2H96_00515	COG0567	Dehydrogenase, E1 component
C2H96_00520	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H96_00525	COG0385	Bile acid
C2H96_00530	COG0733	neurotransmitter:sodium symporter activity
C2H96_00535	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2H96_00540	COG1657	PFAM Prenyltransferase squalene oxidase
C2H96_00545	COG1012	belongs to the aldehyde dehydrogenase family
C2H96_00570	COG0071	Belongs to the small heat shock protein (HSP20) family
C2H96_00585	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2H96_00590	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2H96_00605	COG0514	ATP-dependent DNA helicase (RecQ)
C2H96_00610	COG1388	LysM domain
C2H96_00610	COG3584	3D domain protein
C2H96_00615	COG2197	response regulator
C2H96_00620	COG4585	Histidine kinase
C2H96_00625	COG3239	Fatty acid desaturase
C2H96_00630	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2H96_00645	COG2322	membrane
C2H96_00655	COG0640	Transcriptional regulator
C2H96_00665	COG2378	regulation of single-species biofilm formation
C2H96_00670	COG3708	Transcriptional regulator
C2H96_00675	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H96_00680	COG1309	transcriptional regulator
C2H96_00685	COG0456	acetyltransferase
C2H96_00690	COG2207	Transcriptional regulator
C2H96_00690	COG0662	Cupin 2, conserved barrel domain protein
C2H96_00695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H96_00700	COG1231	oxidoreductase activity
C2H96_00705	COG4282	regulation of fungal-type cell wall biogenesis
C2H96_00710	COG5444	nuclease activity
C2H96_00740	COG0726	polysaccharide deacetylase
C2H96_00745	COG0574	Belongs to the PEP-utilizing enzyme family
C2H96_00745	COG3848	Pyruvate phosphate dikinase
C2H96_00765	COG2367	Beta-lactamase
C2H96_00770	COG0693	protein deglycase activity
C2H96_00780	COG0697	spore germination
C2H96_00785	COG0583	DNA-binding transcription factor activity
C2H96_00790	COG3739	integral membrane protein
C2H96_00795	COG3655	Transcriptional regulator
C2H96_00805	COG2720	vancomycin resistance protein
C2H96_00825	COG2140	Oxalate decarboxylase
C2H96_00835	COG2135	peptidase activity
C2H96_00840	COG3866	Pectate lyase
C2H96_00845	COG3619	membrane
C2H96_00850	COG4305	rare lipoprotein A
C2H96_00855	COG2368	4-hydroxyphenylacetate
C2H96_00860	COG0840	transmembrane signaling receptor activity
C2H96_00860	COG5278	phosphoserine phosphatase activity
C2H96_00885	COG0243	molybdopterin cofactor binding
C2H96_00890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2H96_00895	COG1070	Carbohydrate kinase
C2H96_00900	COG2814	Major facilitator Superfamily
C2H96_00905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H96_00915	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
C2H96_00920	COG0300	oxidoreductase activity
C2H96_00930	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2H96_00935	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C2H96_00940	COG0583	DNA-binding transcription factor activity
C2H96_00945	COG0067	glutamate synthase
C2H96_00945	COG0070	glutamate synthase
C2H96_00945	COG0069	glutamate synthase activity
C2H96_00950	COG0493	'glutamate synthase
C2H96_00955	COG0604	alcohol dehydrogenase
C2H96_00960	COG0583	DNA-binding transcription factor activity
C2H96_00965	COG0405	Gamma-glutamyltransferase
C2H96_00970	COG0166	Belongs to the GPI family
C2H96_00975	COG0582	viral genome integration into host DNA
C2H96_00990	COG0534	Mate efflux family protein
C2H96_00995	COG2017	converts alpha-aldose to the beta-anomer
C2H96_01000	COG2027	D-alanyl-D-alanine carboxypeptidase
C2H96_01005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H96_01010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H96_01015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H96_01020	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H96_01025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H96_01025	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C2H96_01035	COG1649	PFAM Uncharacterised BCR, COG1649
C2H96_01040	COG1960	acyl-CoA dehydrogenase activity
C2H96_01045	COG0318	PFAM AMP-dependent synthetase and ligase
C2H96_01050	COG0439	Biotin carboxylase
C2H96_01055	COG0511	ligase activity, forming carbon-carbon bonds
C2H96_01060	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2H96_01065	COG1024	Enoyl-CoA hydratase
C2H96_01070	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2H96_01075	COG2404	hydrolase activity, acting on ester bonds
C2H96_01080	COG0586	Pfam SNARE associated Golgi protein
C2H96_01085	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2H96_01090	COG2246	polysaccharide biosynthetic process
C2H96_01095	COG3507	Belongs to the glycosyl hydrolase 43 family
C2H96_01100	COG5520	Belongs to the glycosyl hydrolase 30 family
C2H96_01110	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
C2H96_01115	COG1115	amino acid carrier protein
C2H96_01125	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2H96_01130	COG0187	DNA topoisomerase II activity
C2H96_01135	COG1832	CoA-binding protein
C2H96_01140	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
C2H96_01145	COG4841	protein insertion into membrane
C2H96_01155	COG0824	Thioesterase
C2H96_01175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H96_01180	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C2H96_01195	COG0071	Belongs to the small heat shock protein (HSP20) family
C2H96_01205	COG4846	Membrane protein involved in cytochrome C biogenesis
C2H96_01210	COG2201	protein-glutamate methylesterase activity
C2H96_01215	COG0785	Cytochrome C biogenesis protein
C2H96_01225	COG3763	UPF0154 protein
C2H96_01235	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C2H96_01240	COG4224	UPF0291 protein
C2H96_01245	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2H96_01250	COG1388	LysM domain
C2H96_01255	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
C2H96_01265	COG0346	lactoylglutathione lyase activity
C2H96_01275	COG4195	phage-related replication protein
C2H96_01305	COG0531	amino acid
C2H96_01310	COG0697	spore germination
C2H96_01320	COG3832	glyoxalase III activity
C2H96_01330	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2H96_01370	COG0756	dUTP diphosphatase activity
C2H96_01385	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2H96_01390	COG2814	Major facilitator Superfamily
C2H96_01395	COG1525	nuclease
C2H96_01405	COG1070	Carbohydrate kinase
C2H96_01410	COG2115	Belongs to the xylose isomerase family
C2H96_01415	COG1940	carbohydrate kinase activity
C2H96_01420	COG3507	Belongs to the glycosyl hydrolase 43 family
C2H96_01425	COG2211	Major facilitator Superfamily
C2H96_01430	COG0135	phosphoribosylanthranilate isomerase activity
C2H96_01485	COG0463	Glycosyl transferase, family 2
C2H96_01525	COG5444	nuclease activity
C2H96_01535	COG1388	LysM domain
C2H96_01535	COG3409	Peptidoglycan-binding domain 1 protein
C2H96_01535	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2H96_01540	COG4824	toxin secretion phage lysis holin
C2H96_01570	COG3942	CHAP domain
C2H96_01570	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2H96_01685	COG0582	viral genome integration into host DNA
C2H96_01765	COG4974	Belongs to the 'phage' integrase family
C2H96_01770	COG0174	glutamine synthetase
C2H96_01775	COG0789	Transcriptional regulator
C2H96_01780	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
C2H96_01785	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C2H96_01790	COG0464	growth
C2H96_01800	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H96_01805	COG4112	unkown
C2H96_01810	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2H96_01815	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C2H96_01820	COG1780	Probably involved in ribonucleotide reductase function
C2H96_01835	COG1923	regulation of RNA biosynthetic process
C2H96_01840	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
C2H96_01855	COG2076	Multidrug Resistance protein
C2H96_01860	COG2076	Multidrug Resistance protein
C2H96_01865	COG1764	response to oxidative stress
C2H96_01870	COG4195	phage-related replication protein
C2H96_01880	COG1404	Belongs to the peptidase S8 family
C2H96_01885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H96_01895	COG2124	cytochrome p450
C2H96_01900	COG3321	synthase
C2H96_01900	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C2H96_01900	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C2H96_01900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H96_01905	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_01905	COG4221	oxidoreductase activity
C2H96_01905	COG3321	synthase
C2H96_01905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H96_01910	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H96_01910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H96_01910	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_01910	COG3321	synthase
C2H96_01910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H96_01915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H96_01915	COG0300	oxidoreductase activity
C2H96_01915	COG3321	synthase
C2H96_01915	COG4221	oxidoreductase activity
C2H96_01920	COG3321	synthase
C2H96_01920	COG0300	oxidoreductase activity
C2H96_01920	COG0318	PFAM AMP-dependent synthetase and ligase
C2H96_01920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H96_01920	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_01925	COG1024	Enoyl-CoA hydratase
C2H96_01930	COG1024	Enoyl-CoA hydratase
C2H96_01935	COG3425	synthase
C2H96_01940	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2H96_01945	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H96_01950	COG2070	2-Nitropropane dioxygenase
C2H96_01950	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2H96_01955	COG3321	synthase
C2H96_01960	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2H96_01970	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H96_01975	COG3226	Transcriptional regulator
C2H96_01990	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
C2H96_01995	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
C2H96_02005	COG4550	Control of competence regulator ComK, YlbF/YmcA
C2H96_02010	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2H96_02015	COG0156	8-amino-7-oxononanoate synthase activity
C2H96_02020	COG1063	alcohol dehydrogenase
C2H96_02025	COG2359	stage V sporulation protein S
C2H96_02030	COG1692	metallophosphoesterase
C2H96_02035	COG1418	mRNA catabolic process
C2H96_02040	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2H96_02045	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
C2H96_02050	COG1546	Belongs to the CinA family
C2H96_02050	COG1058	Belongs to the CinA family
C2H96_02055	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C2H96_02060	COG1426	Protein conserved in bacteria
C2H96_02075	COG0300	oxidoreductase activity
C2H96_02080	COG0612	Peptidase, M16
C2H96_02085	COG0612	Peptidase, M16
C2H96_02090	COG2814	Major facilitator Superfamily
C2H96_02095	COG2188	Transcriptional regulator
C2H96_02100	COG1674	ftsk spoiiie
C2H96_02100	COG4980	gas vesicle protein
C2H96_02110	COG0740	serine-type endopeptidase activity
C2H96_02115	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2H96_02120	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2H96_02125	COG0527	aspartate kinase activity
C2H96_02130	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C2H96_02135	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2H96_02140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2H96_02145	COG1873	PFAM PRC-barrel domain
C2H96_02150	COG0612	Peptidase, M16
C2H96_02155	COG0726	polysaccharide deacetylase
C2H96_02160	COG1185	polyribonucleotide nucleotidyltransferase activity
C2H96_02165	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
C2H96_02170	COG0196	riboflavin kinase activity
C2H96_02175	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C2H96_02180	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
C2H96_02185	COG1550	Protein conserved in bacteria
C2H96_02190	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
C2H96_02195	COG1358	cellular component organization or biogenesis
C2H96_02200	COG2740	Nucleic-acid-binding protein implicated in transcription termination
C2H96_02205	COG0195	Participates in both transcription termination and antitermination
C2H96_02210	COG0779	Required for maturation of 30S ribosomal subunits
C2H96_02215	COG2176	DNA-directed DNA polymerase activity
C2H96_02220	COG0442	prolyl-tRNA aminoacylation
C2H96_02225	COG0750	zinc metalloprotease
C2H96_02230	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
C2H96_02235	COG4589	Belongs to the CDS family
C2H96_02240	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C2H96_02245	COG0233	cytoplasmic translational termination
C2H96_02250	COG0528	UMP kinase activity
C2H96_02255	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
C2H96_02260	COG0052	Belongs to the universal ribosomal protein uS2 family
C2H96_02270	COG1191	sigma factor activity
C2H96_02275	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
C2H96_02280	COG1776	CheC inhibitor of MCP methylation
C2H96_02285	COG0835	chemotaxis
C2H96_02290	COG2198	Histidine kinase
C2H96_02290	COG0643	Histidine kinase
C2H96_02295	COG2201	protein-glutamate methylesterase activity
C2H96_02300	COG0455	bacterial-type flagellum organization
C2H96_02305	COG1419	protein localization to endoplasmic reticulum
C2H96_02310	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2H96_02315	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C2H96_02320	COG1684	flagellar biosynthetic protein fliR
C2H96_02325	COG1987	bacterial-type flagellum assembly
C2H96_02330	COG1338	Plays a role in the flagellum-specific transport system
C2H96_02335	COG3190	flagellar
C2H96_02340	COG2201	protein-glutamate methylesterase activity
C2H96_02345	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2H96_02345	COG1776	CheC inhibitor of MCP methylation
C2H96_02350	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2H96_02355	COG1580	Controls the rotational direction of flagella during chemotaxis
C2H96_02360	COG1582	Flagellar protein (FlbD)
C2H96_02365	COG4786	Flagellar basal body rod
C2H96_02370	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C2H96_02375	COG3144	bacterial-type flagellum assembly
C2H96_02380	COG3334	PFAM MgtE intracellular
C2H96_02385	COG2882	bacterial-type flagellum organization
C2H96_02390	COG1157	protein secretion by the type III secretion system
C2H96_02395	COG1317	bacterial-type flagellum organization
C2H96_02400	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C2H96_02405	COG1766	The M ring may be actively involved in energy transduction
C2H96_02410	COG1677	Flagellar hook-basal body complex protein FliE
C2H96_02415	COG1558	bacterial-type flagellum-dependent cell motility
C2H96_02420	COG1815	bacterial-type flagellum-dependent cell motility
C2H96_02425	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C2H96_02430	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
C2H96_02435	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C2H96_02440	COG4974	Belongs to the 'phage' integrase family
C2H96_02445	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
C2H96_02450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2H96_02455	COG0758	DNA mediated transformation
C2H96_02460	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C2H96_02465	COG0045	succinate-CoA ligase (ADP-forming) activity
C2H96_02470	COG2257	FlhB HrpN YscU SpaS Family
C2H96_02480	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2H96_02485	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2H96_02490	COG0335	large ribosomal subunit rRNA binding
C2H96_02495	COG0336	Belongs to the RNA methyltransferase TrmD family
C2H96_02500	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C2H96_02510	COG1837	Belongs to the UPF0109 family
C2H96_02515	COG0228	four-way junction DNA binding
C2H96_02520	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C2H96_02525	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
C2H96_02535	COG0552	protein localization to endoplasmic reticulum
C2H96_02540	COG1196	nuclear chromosome segregation
C2H96_02545	COG0571	ribonuclease III activity
C2H96_02555	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_02560	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C2H96_02565	COG0416	fatty acid biosynthetic process
C2H96_02570	COG2050	protein possibly involved in aromatic compounds catabolism
C2H96_02570	COG1349	DNA-binding transcription factor activity
C2H96_02575	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
C2H96_02580	COG1760	l-serine dehydratase
C2H96_02585	COG1760	l-serine dehydratase
C2H96_02590	COG1461	Dihydroxyacetone kinase
C2H96_02595	COG1302	Protein conserved in bacteria
C2H96_02600	COG0227	Belongs to the bacterial ribosomal protein bL28 family
C2H96_02610	COG1564	THIamine pyrophosphokinase
C2H96_02615	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C2H96_02620	COG1162	GTPase activity
C2H96_02625	COG2815	serine threonine protein kinase
C2H96_02625	COG0515	serine threonine protein kinase
C2H96_02630	COG0631	protein serine/threonine phosphatase activity
C2H96_02635	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C2H96_02640	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2H96_02640	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C2H96_02645	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
C2H96_02650	COG0242	peptide deformylase activity
C2H96_02655	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2H96_02660	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C2H96_02665	COG1758	RNA polymerase activity
C2H96_02670	COG0194	GDP metabolic process
C2H96_02680	COG1561	YicC-like family, N-terminal region
C2H96_02685	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C2H96_02690	COG1293	RNA-binding protein homologous to eukaryotic snRNP
C2H96_02695	COG1648	precorrin-2 dehydrogenase activity
C2H96_02700	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
C2H96_02705	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2H96_02710	COG0529	Catalyzes the synthesis of activated sulfate
C2H96_02715	COG2046	Belongs to the sulfate adenylyltransferase family
C2H96_02720	COG0306	phosphate transporter
C2H96_02725	COG0175	sulfate reduction
C2H96_02730	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
C2H96_02735	COG0284	orotidine-5'-phosphate decarboxylase activity
C2H96_02740	COG0167	dihydroorotate dehydrogenase activity
C2H96_02745	COG0543	2 iron, 2 sulfur cluster binding
C2H96_02750	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C2H96_02755	COG0505	Belongs to the CarA family
C2H96_02760	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2H96_02765	COG0540	Belongs to the ATCase OTCase family
C2H96_02770	COG2233	PERMEase
C2H96_02775	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
C2H96_02780	COG0564	pseudouridine synthase activity
C2H96_02785	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
C2H96_02790	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2H96_02795	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
C2H96_02800	COG3599	regulation of cell shape
C2H96_02805	COG2302	S4 RNA-binding domain
C2H96_02810	COG0762	integral membrane protein
C2H96_02815	COG1799	cell septum assembly
C2H96_02820	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C2H96_02825	COG1496	oxidoreductase activity
C2H96_02830	COG1873	PFAM PRC-barrel domain
C2H96_02835	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2H96_02840	COG1119	ATPase activity
C2H96_02845	COG1191	sigma factor activity
C2H96_02850	COG1191	sigma factor activity
C2H96_02860	COG1404	Belongs to the peptidase S8 family
C2H96_02860	COG4412	M6 family metalloprotease domain protein
C2H96_02865	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C2H96_02870	COG0849	cell division
C2H96_02875	COG3856	small basic protein
C2H96_02880	COG3879	Bacterial protein of unknown function (DUF881)
C2H96_02885	COG3879	Bacterial protein of unknown function (DUF881)
C2H96_02890	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C2H96_02895	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C2H96_02900	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2H96_02905	COG0772	Belongs to the SEDS family
C2H96_02910	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2H96_02915	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2H96_02920	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C2H96_02925	COG0768	penicillin binding
C2H96_02930	COG0768	penicillin binding
C2H96_02935	COG4839	cell division protein FtsL
C2H96_02940	COG0275	rRNA processing
C2H96_02945	COG2001	Belongs to the MraZ family
C2H96_02950	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
C2H96_02955	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2H96_02960	COG0454	-acetyltransferase
C2H96_02975	COG1399	metal-binding, possibly nucleic acid-binding protein
C2H96_02985	COG1323	Belongs to the UPF0348 family
C2H96_02990	COG3480	Lon protease (S16) C-terminal proteolytic domain
C2H96_02995	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2H96_03000	COG3314	Sporulation integral membrane protein YlbJ
C2H96_03005	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
C2H96_03010	COG0742	ribosomal rna small subunit methyltransferase
C2H96_03015	COG4471	UPF0298 protein
C2H96_03020	COG3679	Belongs to the UPF0342 family
C2H96_03035	COG2340	Cysteine-rich secretory protein family
C2H96_03040	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
C2H96_03050	COG3336	cytochrome c oxidase
C2H96_03055	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2H96_03060	COG1845	cytochrome c oxidase, subunit III
C2H96_03065	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2H96_03070	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2H96_03070	COG2010	Cytochrome c
C2H96_03075	COG0109	protoheme IX farnesyltransferase activity
C2H96_03080	COG1612	heme a metabolic process
C2H96_03085	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C2H96_03090	COG0772	Belongs to the SEDS family
C2H96_03095	COG4838	Belongs to the UPF0358 family
C2H96_03100	COG2066	Belongs to the glutaminase family
C2H96_03105	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2H96_03110	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
C2H96_03120	COG4896	Protein conserved in bacteria
C2H96_03130	COG1217	gtp-binding protein TYPA
C2H96_03150	COG1595	DNA-templated transcription, initiation
C2H96_03170	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
C2H96_03180	COG0483	inositol monophosphate 1-phosphatase activity
C2H96_03190	COG4493	Belongs to the UPF0637 family
C2H96_03195	COG4476	Belongs to the UPF0223 family
C2H96_03200	COG1982	Orn Lys Arg decarboxylase major
C2H96_03210	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H96_03215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2H96_03220	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H96_03225	COG0022	dehydrogenase e1 component
C2H96_03230	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2H96_03235	COG0497	DNA recombination
C2H96_03245	COG0242	peptide deformylase activity
C2H96_03250	COG0561	phosphatase activity
C2H96_03255	COG5503	Protein of unknown function (DUF1447)
C2H96_03260	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
C2H96_03265	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C2H96_03270	COG0569	domain protein
C2H96_03275	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
C2H96_03275	COG2105	PFAM AIG2 family protein
C2H96_03280	COG3852	Histidine kinase
C2H96_03285	COG2002	toxin-antitoxin pair type II binding
C2H96_03290	COG1077	Cell shape determining protein MreB Mrl
C2H96_03300	COG2309	aminopeptidase activity
C2H96_03305	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
C2H96_03310	COG0488	(ABC) transporter
C2H96_03320	COG0681	Belongs to the peptidase S26 family
C2H96_03325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H96_03325	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H96_03325	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H96_03330	COG1105	Belongs to the carbohydrate kinase PfkB family
C2H96_03335	COG1349	DNA-binding transcription factor activity
C2H96_03340	COG0577	efflux transmembrane transporter activity
C2H96_03345	COG1136	(ABC) transporter
C2H96_03350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2H96_03360	COG1132	(ABC) transporter
C2H96_03365	COG1132	(ABC) transporter
C2H96_03370	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C2H96_03375	COG0314	molybdopterin synthase activity
C2H96_03380	COG1763	Mo-molybdopterin cofactor biosynthetic process
C2H96_03385	COG0303	'Molybdopterin
C2H96_03390	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2H96_03395	COG0746	molybdenum cofactor guanylyltransferase activity
C2H96_03410	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H96_03415	COG0450	alkyl hydroperoxide reductase
C2H96_03420	COG0668	transmembrane transport
C2H96_03430	COG1473	amidohydrolase
C2H96_03435	COG2171	N-acyltransferase activity
C2H96_03440	COG0716	FMN binding
C2H96_03450	COG0716	FMN binding
C2H96_03455	COG0583	DNA-binding transcription factor activity
C2H96_03460	COG0517	IMP dehydrogenase activity
C2H96_03470	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
C2H96_03475	COG4703	Protein of unknown function (DUF1797)
C2H96_03480	COG2200	EAL domain
C2H96_03485	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_03490	COG1408	metallophosphoesterase
C2H96_03495	COG1376	ErfK ybiS ycfS ynhG family protein
C2H96_03500	COG2814	Major facilitator Superfamily
C2H96_03510	COG0784	Response regulator, receiver
C2H96_03510	COG0835	chemotaxis
C2H96_03520	COG0436	Aminotransferase
C2H96_03525	COG4191	Histidine kinase
C2H96_03530	COG0768	penicillin binding
C2H96_03535	COG2340	Cysteine-rich secretory protein family
C2H96_03540	COG4257	antibiotic catabolic process
C2H96_03545	COG2084	Dehydrogenase
C2H96_03550	COG0840	transmembrane signaling receptor activity
C2H96_03555	COG0456	acetyltransferase
C2H96_03560	COG1533	DNA photolyase activity
C2H96_03570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C2H96_03575	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H96_03580	COG1263	PTS System
C2H96_03580	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H96_03580	COG2190	(PTS) system
C2H96_03585	COG3711	transcriptional antiterminator
C2H96_03590	COG1609	Transcriptional regulator
C2H96_03595	COG0006	proline dipeptidase activity
C2H96_03605	COG2217	Heavy metal translocating P-type atpase
C2H96_03610	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H96_03615	COG2244	polysaccharide biosynthetic process
C2H96_03620	COG3773	Cell wall hydrolase
C2H96_03630	COG4873	Protein conserved in bacteria
C2H96_03640	COG3858	chitin binding
C2H96_03645	COG1388	LysM domain
C2H96_03650	COG4641	Protein conserved in bacteria
C2H96_03650	COG1388	LysM domain
C2H96_03655	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_03660	COG1733	regulation of RNA biosynthetic process
C2H96_03665	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
C2H96_03670	COG0602	queuosine metabolic process
C2H96_03675	COG0720	synthase
C2H96_03680	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
C2H96_03685	COG3949	Membrane
C2H96_03690	COG0542	response to heat
C2H96_03695	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2H96_03700	COG1360	Flagellar Motor Protein
C2H96_03705	COG1846	Transcriptional regulator
C2H96_03710	COG3852	Histidine kinase
C2H96_03725	COG3339	Conserved Protein
C2H96_03730	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
C2H96_03735	COG0235	Class ii aldolase
C2H96_03740	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
C2H96_03745	COG1850	ribulose-bisphosphate carboxylase activity
C2H96_03750	COG0436	Aminotransferase
C2H96_03755	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2H96_03760	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
C2H96_03765	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
C2H96_03770	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2H96_03775	COG5002	protein histidine kinase activity
C2H96_03780	COG3594	Acyltransferase
C2H96_03795	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2H96_03800	COG0501	Belongs to the peptidase M48B family
C2H96_03820	COG1191	sigma factor activity
C2H96_03825	COG0861	Integral membrane protein TerC family
C2H96_03830	COG0586	Pfam SNARE associated Golgi protein
C2H96_03835	COG3300	MHYT domain
C2H96_03835	COG5001	Diguanylate cyclase
C2H96_03840	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
C2H96_03845	COG3285	dna ligase
C2H96_03845	COG1793	dna ligase
C2H96_03850	COG0463	Glycosyl transferase, family 2
C2H96_03860	COG1408	metallophosphoesterase
C2H96_03865	COG0726	polysaccharide deacetylase
C2H96_03870	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C2H96_03875	COG1846	Transcriptional regulator
C2H96_03890	COG0789	Transcriptional regulator
C2H96_03895	COG2239	Acts as a magnesium transporter
C2H96_03910	COG3212	peptidase
C2H96_03915	COG3212	peptidase
C2H96_03920	COG5002	protein histidine kinase activity
C2H96_03920	COG3850	Histidine kinase
C2H96_03925	COG0745	RESPONSE REGULATOR receiver
C2H96_03935	COG4721	ABC-type cobalt transport system, permease component
C2H96_03940	COG1122	ATPase activity
C2H96_03945	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C2H96_03950	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H96_03955	COG1404	Belongs to the peptidase S8 family
C2H96_03960	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2H96_03965	COG0590	tRNA wobble adenosine to inosine editing
C2H96_03970	COG1764	response to oxidative stress
C2H96_03975	COG1846	Transcriptional regulator
C2H96_03980	COG1764	response to oxidative stress
C2H96_03985	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
C2H96_03990	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
C2H96_03995	COG0788	formyltetrahydrofolate deformylase activity
C2H96_04000	COG2076	Multidrug Resistance protein
C2H96_04005	COG2076	Multidrug Resistance protein
C2H96_04010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H96_04015	COG2318	DinB family
C2H96_04020	COG2323	membrane
C2H96_04030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C2H96_04030	COG1017	nitric oxide dioxygenase activity
C2H96_04035	COG1607	acyl-coa hydrolase
C2H96_04040	COG1834	amidinotransferase
C2H96_04045	COG2706	6-phosphogluconolactonase activity
C2H96_04050	COG4608	Belongs to the ABC transporter superfamily
C2H96_04055	COG0791	NLP P60 protein
C2H96_04060	COG4948	Mandelate Racemase Muconate Lactonizing
C2H96_04065	COG1619	proteins homologs of microcin C7 resistance protein MccF
C2H96_04070	COG4166	transmembrane transport
C2H96_04075	COG0444	Belongs to the ABC transporter superfamily
C2H96_04080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2H96_04085	COG0601	transmembrane transport
C2H96_04090	COG2362	D-Aminopeptidase
C2H96_04095	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2H96_04100	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H96_04110	COG0463	Glycosyl transferase, family 2
C2H96_04115	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2H96_04120	COG0346	lactoylglutathione lyase activity
C2H96_04125	COG0531	amino acid
C2H96_04130	COG1392	Phosphate transport regulator
C2H96_04135	COG0306	phosphate transporter
C2H96_04150	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2H96_04150	COG3409	Peptidoglycan-binding domain 1 protein
C2H96_04190	COG3778	Protein conserved in bacteria
C2H96_04195	COG3299	homolog of phage Mu protein gp47
C2H96_04200	COG3628	GPW Gp25 family protein
C2H96_04210	COG4193	domain, Protein
C2H96_04215	COG1652	LysM domain
C2H96_04220	COG3953	SLT domain
C2H96_04220	COG5412	phage tail tape measure protein
C2H96_04220	COG3953	SLT domain
C2H96_04220	COG5412	phage tail tape measure protein
C2H96_04270	COG4653	Phage capsid family
C2H96_04275	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C2H96_04280	COG5518	Phage portal protein
C2H96_04285	COG1783	phage Terminase large subunit
C2H96_04290	COG5484	DNA packaging
C2H96_04290	COG3728	DNA packaging
C2H96_04295	COG1595	DNA-templated transcription, initiation
C2H96_04315	COG1484	DNA-dependent DNA replication
C2H96_04320	COG1522	sequence-specific DNA binding
C2H96_04330	COG1396	sequence-specific DNA binding
C2H96_04335	COG2856	Zn peptidase
C2H96_04340	COG3546	catalase activity
C2H96_04345	COG4195	phage-related replication protein
C2H96_04355	COG3409	Peptidoglycan-binding domain 1 protein
C2H96_04355	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2H96_04355	COG1388	LysM domain
C2H96_04360	COG2350	Protein conserved in bacteria
C2H96_04370	COG0457	Tetratricopeptide repeat
C2H96_04375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2H96_04380	COG2318	DinB family
C2H96_04385	COG0730	response to heat
C2H96_04390	COG2721	sulfolactate sulfo-lyase activity
C2H96_04395	COG0246	Mannitol dehydrogenase
C2H96_04400	COG1609	Transcriptional regulator
C2H96_04405	COG2271	Major facilitator Superfamily
C2H96_04410	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_04415	COG1312	Catalyzes the dehydration of D-mannonate
C2H96_04420	COG1063	alcohol dehydrogenase
C2H96_04425	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C2H96_04430	COG2211	Major facilitator Superfamily
C2H96_04435	COG1904	glucuronate isomerase
C2H96_04440	COG1252	NADH dehydrogenase
C2H96_04450	COG4297	protein containing double-stranded beta helix domain
C2H96_04455	COG0697	spore germination
C2H96_04460	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2H96_04465	COG0390	transport system, permease component
C2H96_04470	COG1587	Uroporphyrinogen-III synthase
C2H96_04480	COG1819	glycosyl
C2H96_04485	COG2124	cytochrome p450
C2H96_04495	COG1051	belongs to the nudix hydrolase family
C2H96_04505	COG2427	Protein of unknown function (DUF1641)
C2H96_04510	COG3383	formate dehydrogenase (NAD+) activity
C2H96_04520	COG2205	protein histidine kinase activity
C2H96_04525	COG5504	Zn-dependent protease
C2H96_04540	COG0726	polysaccharide deacetylase
C2H96_04550	COG0109	protoheme IX farnesyltransferase activity
C2H96_04570	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C2H96_04580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H96_04590	COG1482	cell wall glycoprotein biosynthetic process
C2H96_04595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H96_04595	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H96_04595	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
C2H96_04600	COG3711	transcriptional antiterminator
C2H96_04600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H96_04610	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C2H96_04635	COG5444	nuclease activity
C2H96_04660	COG5505	Protein of unknown function (DUF819)
C2H96_04665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H96_04670	COG0626	cystathionine gamma-synthase activity
C2H96_04675	COG0626	cystathionine gamma-synthase activity
C2H96_04680	COG2382	esterase
C2H96_04685	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2H96_04690	COG2153	protein acetylation
C2H96_04700	COG0210	DNA helicase
C2H96_04755	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C2H96_04760	COG0351	phosphomethylpyrimidine kinase
C2H96_04765	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
C2H96_04770	COG2022	thiamine diphosphate biosynthetic process
C2H96_04775	COG2104	thiamine diphosphate biosynthetic process
C2H96_04780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2H96_04785	COG0352	thiamine-phosphate diphosphorylase activity
C2H96_04790	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C2H96_04795	COG0475	glutathione-regulated potassium exporter activity
C2H96_04795	COG0569	domain protein
C2H96_04800	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
C2H96_04805	COG0564	pseudouridine synthase activity
C2H96_04810	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2H96_04815	COG2357	RelA SpoT domain protein
C2H96_04825	COG4116	CYTH
C2H96_04830	COG0741	lytic transglycosylase activity
C2H96_04835	COG2346	COG2346, Truncated hemoglobins
C2H96_04840	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C2H96_04855	COG1164	Oligoendopeptidase f
C2H96_04860	COG4469	Competence protein
C2H96_04865	COG4862	establishment of competence for transformation
C2H96_04870	COG0861	Integral membrane protein TerC family
C2H96_04875	COG1393	Belongs to the ArsC family
C2H96_04880	COG0456	acetyltransferase
C2H96_04890	COG4608	Belongs to the ABC transporter superfamily
C2H96_04895	COG0444	Belongs to the ABC transporter superfamily
C2H96_04900	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2H96_04905	COG0601	transmembrane transport
C2H96_04910	COG4166	transmembrane transport
C2H96_04915	COG0180	Tryptophanyl-tRNA synthetase
C2H96_04925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C2H96_04930	COG0601	transmembrane transport
C2H96_04940	COG4608	Belongs to the ABC transporter superfamily
C2H96_04945	COG0444	Belongs to the ABC transporter superfamily
C2H96_04950	COG5504	Zn-dependent protease
C2H96_04955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C2H96_04960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2H96_04975	COG1744	ABC transporter substrate-binding protein PnrA-like
C2H96_04985	COG2267	carboxylic ester hydrolase activity
C2H96_05000	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
C2H96_05010	COG0505	Belongs to the CarA family
C2H96_05015	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2H96_05025	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
C2H96_05030	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
C2H96_05035	COG2271	Major facilitator Superfamily
C2H96_05040	COG0277	FAD linked oxidase domain protein
C2H96_05050	COG2151	metal-sulfur cluster biosynthetic enzyme
C2H96_05055	COG1073	alpha beta
C2H96_05060	COG0561	phosphatase activity
C2H96_05075	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H96_05080	COG1307	EDD domain protein, DegV family
C2H96_05085	COG3227	Zinc metalloprotease (Elastase)
C2H96_05100	COG1695	Transcriptional regulator
C2H96_05120	COG2996	Protein conserved in bacteria
C2H96_05125	COG1666	GTP binding
C2H96_05130	COG0646	methionine synthase
C2H96_05130	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C2H96_05135	COG2153	protein acetylation
C2H96_05140	COG0454	-acetyltransferase
C2H96_05145	COG2814	Major facilitator Superfamily
C2H96_05150	COG4948	Mandelate Racemase Muconate Lactonizing
C2H96_05155	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H96_05160	COG1809	phosphosulfolactate synthase activity
C2H96_05165	COG2045	Belongs to the ComB family
C2H96_05170	COG0175	sulfate reduction
C2H96_05175	COG2046	Belongs to the sulfate adenylyltransferase family
C2H96_05180	COG0529	Catalyzes the synthesis of activated sulfate
C2H96_05185	COG2267	carboxylic ester hydrolase activity
C2H96_05190	COG1357	PFAM Pentapeptide repeats (8 copies)
C2H96_05200	COG1279	arginine transmembrane transporter activity
C2H96_05205	COG2318	DinB family
C2H96_05210	COG0673	inositol 2-dehydrogenase activity
C2H96_05215	COG1609	Transcriptional regulator
C2H96_05220	COG1917	Cupin 2, conserved barrel domain protein
C2H96_05220	COG2207	Transcriptional regulator
C2H96_05225	COG0534	Mate efflux family protein
C2H96_05230	COG1562	ergosterol biosynthetic process
C2H96_05235	COG2318	DinB family
C2H96_05240	COG0367	asparagine synthase
C2H96_05250	COG1404	Belongs to the peptidase S8 family
C2H96_05260	COG0179	Fumarylacetoacetate (FAA) hydrolase
C2H96_05265	COG5337	Spore coat protein CotH
C2H96_05305	COG1403	HNH endonuclease
C2H96_05310	COG0419	ATPase involved in DNA repair
C2H96_05315	COG0420	3'-5' exonuclease activity
C2H96_05320	COG1074	ATP-dependent DNA helicase activity
C2H96_05325	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
C2H96_05330	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
C2H96_05340	COG4533	DNA binding
C2H96_05345	COG0477	Major facilitator Superfamily
C2H96_05345	COG2814	Major facilitator Superfamily
C2H96_05350	COG3180	Ammonia monooxygenase
C2H96_05355	COG1609	Transcriptional regulator
C2H96_05360	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2H96_05365	COG0561	phosphatase activity
C2H96_05370	COG0673	inositol 2-dehydrogenase activity
C2H96_05375	COG0738	Major facilitator superfamily
C2H96_05390	COG1846	Transcriptional regulator
C2H96_05395	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2H96_05400	COG0681	Belongs to the peptidase S26 family
C2H96_05405	COG0398	Pfam SNARE associated Golgi protein
C2H96_05420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H96_05430	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_05435	COG4903	ComK protein
C2H96_05445	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_05450	COG0723	plastoquinol--plastocyanin reductase activity
C2H96_05450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2H96_05455	COG0840	transmembrane signaling receptor activity
C2H96_05460	COG1268	BioY protein
C2H96_05465	COG0318	PFAM AMP-dependent synthetase and ligase
C2H96_05470	COG0183	Belongs to the thiolase family
C2H96_05475	COG0406	alpha-ribazole phosphatase activity
C2H96_05480	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C2H96_05485	COG0604	alcohol dehydrogenase
C2H96_05490	COG0456	acetyltransferase
C2H96_05500	COG0501	Belongs to the peptidase M48B family
C2H96_05510	COG0318	PFAM AMP-dependent synthetase and ligase
C2H96_05515	COG0702	epimerase
C2H96_05520	COG0095	Lipoate-protein ligase
C2H96_05525	COG1234	tRNA 3'-trailer cleavage
C2H96_05535	COG1301	dicarboxylic acid transport
C2H96_05540	COG4405	Protein conserved in bacteria
C2H96_05545	COG1363	Peptidase, m42
C2H96_05555	COG4377	Putative membrane peptidase family (DUF2324)
C2H96_05560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2H96_05565	COG1511	domain protein
C2H96_05570	COG1309	transcriptional regulator
C2H96_05575	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
C2H96_05580	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
C2H96_05585	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
C2H96_05590	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2H96_05595	COG2329	Antibiotic biosynthesis monooxygenase
C2H96_05605	COG3069	C4-dicarboxylate transmembrane transporter activity
C2H96_05610	COG1473	amidohydrolase
C2H96_05620	COG4473	ABC transporter
C2H96_05625	COG1131	(ABC) transporter
C2H96_05630	COG0537	adenosine 5'-monophosphoramidase activity
C2H96_05635	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
C2H96_05650	COG4980	gas vesicle protein
C2H96_05655	COG1846	Transcriptional regulator
C2H96_05685	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2H96_05695	COG3481	metal-dependent phosphohydrolase, HD sub domain
C2H96_05700	COG4717	serine-type aminopeptidase activity
C2H96_05705	COG0420	3'-5' exonuclease activity
C2H96_05710	COG1668	transmembrane transport
C2H96_05715	COG4152	abc transporter atp-binding protein
C2H96_05725	COG1024	Enoyl-CoA hydratase
C2H96_05735	COG0490	domain, Protein
C2H96_05740	COG0475	glutathione-regulated potassium exporter activity
C2H96_05745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2H96_05750	COG0561	phosphatase activity
C2H96_05755	COG4335	DNA alkylation repair
C2H96_05760	COG3679	Belongs to the UPF0342 family
C2H96_05765	COG4399	Belongs to the UPF0754 family
C2H96_05770	COG0189	ligase activity
C2H96_05775	COG0189	ligase activity
C2H96_05795	COG0702	epimerase
C2H96_05800	COG1132	(ABC) transporter
C2H96_05805	COG1132	(ABC) transporter
C2H96_05815	COG0589	response to stress
C2H96_05820	COG1757	Na H antiporter
C2H96_05825	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2H96_05830	COG0726	polysaccharide deacetylase
C2H96_05835	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
C2H96_05840	COG0668	transmembrane transport
C2H96_05850	COG0584	glycerophosphoryl diester phosphodiesterase
C2H96_05855	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2H96_05860	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
C2H96_05865	COG1253	flavin adenine dinucleotide binding
C2H96_05870	COG0436	Aminotransferase
C2H96_05875	COG0789	Transcriptional regulator
C2H96_05880	COG1253	flavin adenine dinucleotide binding
C2H96_05885	COG0204	Acyl-transferase
C2H96_05890	COG0667	Aldo Keto reductase
C2H96_05895	COG1595	DNA-templated transcription, initiation
C2H96_05910	COG0456	acetyltransferase
C2H96_05915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H96_05920	COG0733	neurotransmitter:sodium symporter activity
C2H96_05925	COG0531	amino acid
C2H96_05930	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_05935	COG0372	Belongs to the citrate synthase family
C2H96_05940	COG0583	DNA-binding transcription factor activity
C2H96_05945	COG0791	NLP P60 protein
C2H96_05945	COG1388	LysM domain
C2H96_05950	COG1785	Belongs to the alkaline phosphatase family
C2H96_05955	COG2719	SpoVR family
C2H96_05960	COG0668	transmembrane transport
C2H96_05965	COG1959	2 iron, 2 sulfur cluster binding
C2H96_05970	COG0791	NLP P60 protein
C2H96_05970	COG1388	LysM domain
C2H96_05985	COG0431	NADPH-dependent FMN reductase
C2H96_05990	COG2197	response regulator
C2H96_05995	COG4585	Histidine kinase
C2H96_05995	COG2203	Gaf domain
C2H96_06000	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2H96_06005	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
C2H96_06010	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
C2H96_06015	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C2H96_06020	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
C2H96_06025	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2H96_06030	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
C2H96_06030	COG3153	acetyltransferase
C2H96_06035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2H96_06040	COG0517	IMP dehydrogenase activity
C2H96_06050	COG0564	pseudouridine synthase activity
C2H96_06055	COG3764	Sortase (surface protein transpeptidase)
C2H96_06060	COG4085	toxin activity
C2H96_06060	COG1525	nuclease
C2H96_06060	COG0737	Belongs to the 5'-nucleotidase family
C2H96_06065	COG5577	PFAM Coat F domain
C2H96_06095	COG1823	symporter activity
C2H96_06100	COG3706	GGDEF domain
C2H96_06105	COG1464	Belongs to the NlpA lipoprotein family
C2H96_06115	COG1278	Cold shock
C2H96_06120	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2H96_06125	COG1131	(ABC) transporter
C2H96_06130	COG1131	(ABC) transporter
C2H96_06135	COG1725	Transcriptional regulator
C2H96_06155	COG0655	NAD(P)H dehydrogenase (quinone) activity
C2H96_06160	COG2814	Major facilitator Superfamily
C2H96_06165	COG1566	PFAM secretion protein HlyD family protein
C2H96_06170	COG1846	Transcriptional regulator
C2H96_06175	COG2718	Belongs to the UPF0229 family
C2H96_06180	COG2766	serine protein kinase
C2H96_06185	COG1664	Polymer-forming cytoskeletal
C2H96_06190	COG1664	Polymer-forming cytoskeletal
C2H96_06195	COG0789	Transcriptional regulator
C2H96_06200	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C2H96_06210	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C2H96_06215	COG3382	B3 4 domain protein
C2H96_06225	COG1476	TRANSCRIPTIONal
C2H96_06235	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C2H96_06245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H96_06250	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2H96_06255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2H96_06260	COG1116	anion transmembrane transporter activity
C2H96_06265	COG0753	catalase activity
C2H96_06275	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
C2H96_06280	COG3340	Belongs to the peptidase S51 family
C2H96_06285	COG5577	PFAM Coat F domain
C2H96_06295	COG4326	sporulation control protein
C2H96_06425	COG0735	belongs to the Fur family
C2H96_06430	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C2H96_06435	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2H96_06440	COG4129	membrane
C2H96_06445	COG1132	(ABC) transporter
C2H96_06450	COG3557	Belongs to the UPF0374 family
C2H96_06465	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_06475	COG1194	a g-specific adenine glycosylase
C2H96_06480	COG1988	membrane-bound metal-dependent
C2H96_06485	COG4485	Bacterial membrane protein, YfhO
C2H96_06490	COG0463	Glycosyl transferase, family 2
C2H96_06495	COG0596	Alpha beta hydrolase
C2H96_06500	COG5658	integral membrane protein
C2H96_06505	COG3103	Sh3 type 3 domain protein
C2H96_06520	COG2814	Major facilitator Superfamily
C2H96_06530	COG2137	regulation of response to DNA damage stimulus
C2H96_06535	COG1090	epimerase
C2H96_06550	COG0778	Nitroreductase
C2H96_06555	COG0384	phenazine biosynthesis protein PhzF
C2H96_06560	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H96_06565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H96_06570	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H96_06575	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
C2H96_06575	COG0392	lysyltransferase activity
C2H96_06580	COG1846	Transcriptional regulator
C2H96_06585	COG2814	Major facilitator Superfamily
C2H96_06590	COG2318	DinB family
C2H96_06595	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
C2H96_06600	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C2H96_06605	COG1695	Transcriptional regulator
C2H96_06610	COG0842	Transport permease protein
C2H96_06615	COG0842	Transport permease protein
C2H96_06615	COG1511	domain protein
C2H96_06620	COG1131	(ABC) transporter
C2H96_06630	COG2197	response regulator
C2H96_06635	COG4585	Histidine kinase
C2H96_06640	COG2514	catechol 2,3-dioxygenase activity
C2H96_06645	COG2259	Doxx family
C2H96_06650	COG1132	(ABC) transporter
C2H96_06655	COG1132	(ABC) transporter
C2H96_06660	COG1263	PTS System
C2H96_06660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H96_06665	COG1737	Transcriptional regulator
C2H96_06670	COG1486	melibiose metabolic process
C2H96_06685	COG5444	nuclease activity
C2H96_06710	COG4842	Belongs to the WXG100 family
C2H96_06735	COG1742	UPF0060 membrane protein
C2H96_06745	COG3284	Transcriptional regulator
C2H96_06750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2H96_06755	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H96_06760	COG0022	dehydrogenase e1 component
C2H96_06765	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2H96_06770	COG4637	Psort location Cytoplasmic, score
C2H96_06775	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2H96_06785	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2H96_06790	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2H96_06795	COG0598	Magnesium transport protein CorA
C2H96_06800	COG2084	Dehydrogenase
C2H96_06805	COG0726	polysaccharide deacetylase
C2H96_06815	COG0535	radical SAM domain protein
C2H96_06820	COG0668	transmembrane transport
C2H96_06830	COG0387	Pfam Sodium calcium exchanger
C2H96_06835	COG0477	Major facilitator Superfamily
C2H96_06840	COG1295	ribonuclease BN
C2H96_06845	COG4980	gas vesicle protein
C2H96_06850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2H96_06855	COG4840	Belongs to the UPF0435 family
C2H96_06860	COG2814	Major facilitator Superfamily
C2H96_06865	COG0693	protein deglycase activity
C2H96_06870	COG0737	Belongs to the 5'-nucleotidase family
C2H96_06875	COG0778	Nitroreductase
C2H96_06880	COG2188	Transcriptional regulator
C2H96_06885	COG0366	Alpha amylase catalytic
C2H96_06890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H96_06890	COG1263	PTS System
C2H96_06895	COG0697	spore germination
C2H96_06910	COG0531	amino acid
C2H96_06915	COG1115	amino acid carrier protein
C2H96_06930	COG1368	sulfuric ester hydrolase activity
C2H96_06935	COG1263	PTS System
C2H96_06935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H96_06940	COG0024	Methionine aminopeptidase
C2H96_06960	COG2258	MOSC domain
C2H96_06965	COG1254	Belongs to the acylphosphatase family
C2H96_06970	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
C2H96_06975	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H96_06980	COG2851	Citrate transporter
C2H96_06985	COG3181	Tripartite tricarboxylate transporter family receptor
C2H96_06990	COG4565	transcriptional regulatory protein
C2H96_06995	COG3290	protein histidine kinase activity
C2H96_07000	COG0471	metal ion transport
C2H96_07005	COG3866	Pectate lyase
C2H96_07025	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
C2H96_07030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H96_07035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H96_07040	COG1120	ATPase activity
C2H96_07045	COG2130	NADP-dependent
C2H96_07050	COG0456	acetyltransferase
C2H96_07055	COG0513	Belongs to the DEAD box helicase family
C2H96_07060	COG0488	(ABC) transporter
C2H96_07075	COG1404	Belongs to the peptidase S8 family
C2H96_07080	COG2814	Major facilitator Superfamily
C2H96_07085	COG0789	Transcriptional regulator
C2H96_07095	COG0488	(ABC) transporter
C2H96_07100	COG0840	transmembrane signaling receptor activity
C2H96_07105	COG1012	belongs to the aldehyde dehydrogenase family
C2H96_07110	COG0531	amino acid
C2H96_07115	COG1011	Hydrolase
C2H96_07120	COG2223	nitrite transmembrane transporter activity
C2H96_07125	COG1442	glycosyl transferase family 8
C2H96_07130	COG1216	Glycosyl transferase, family 2
C2H96_07135	COG1442	glycosyl transferase family 8
C2H96_07140	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H96_07145	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C2H96_07150	COG1368	sulfuric ester hydrolase activity
C2H96_07160	COG2124	cytochrome p450
C2H96_07160	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2H96_07175	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C2H96_07180	COG1846	Transcriptional regulator
C2H96_07190	COG0670	Belongs to the BI1 family
C2H96_07195	COG5583	Uncharacterized small protein (DUF2292)
C2H96_07210	COG0346	lactoylglutathione lyase activity
C2H96_07215	COG2329	Antibiotic biosynthesis monooxygenase
C2H96_07220	COG2323	membrane
C2H96_07225	COG1486	melibiose metabolic process
C2H96_07230	COG0395	ABC-type sugar transport system, permease component
C2H96_07235	COG4209	transmembrane transport
C2H96_07240	COG1653	transport
C2H96_07250	COG1874	Beta-galactosidase
C2H96_07255	COG2755	lipolytic protein G-D-S-L family
C2H96_07260	COG3401	FG-GAP repeat protein
C2H96_07265	COG3401	FG-GAP repeat protein
C2H96_07270	COG5578	integral membrane protein
C2H96_07280	COG2755	lipolytic protein G-D-S-L family
C2H96_07285	COG2207	Transcriptional regulator
C2H96_07290	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2H96_07295	COG0395	ABC-type sugar transport system, permease component
C2H96_07300	COG1175	transmembrane transport
C2H96_07305	COG1653	transport
C2H96_07310	COG4753	response regulator
C2H96_07310	COG2207	Transcriptional regulator
C2H96_07315	COG2972	Histidine kinase
C2H96_07320	COG5578	integral membrane protein
C2H96_07330	COG0454	-acetyltransferase
C2H96_07335	COG3546	catalase activity
C2H96_07350	COG0702	epimerase
C2H96_07355	COG3631	Ketosteroid isomerase-related protein
C2H96_07360	COG1309	transcriptional regulator
C2H96_07370	COG0217	transcriptional regulatory protein
C2H96_07380	COG0457	Tetratricopeptide repeat
C2H96_07390	COG3391	amine dehydrogenase activity
C2H96_07395	COG3586	endonuclease activity
C2H96_07405	COG5444	nuclease activity
C2H96_07430	COG0457	Tetratricopeptide repeat
C2H96_07455	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
C2H96_07460	COG1597	lipid kinase activity
C2H96_07465	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C2H96_07470	COG1309	transcriptional regulator
C2H96_07475	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2H96_07480	COG0154	amidase activity
C2H96_07485	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
C2H96_07490	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H96_07495	COG1285	pathogenesis
C2H96_07500	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H96_07505	COG4851	CamS sex pheromone cAM373 precursor
C2H96_07510	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C2H96_07515	COG0210	DNA helicase
C2H96_07520	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
C2H96_07525	COG0069	glutamate synthase activity
C2H96_07530	COG4496	protein, YerC YecD
C2H96_07535	COG1470	cell adhesion involved in biofilm formation
C2H96_07540	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
C2H96_07550	COG0531	amino acid
C2H96_07555	COG1522	sequence-specific DNA binding
C2H96_07560	COG0151	Belongs to the GarS family
C2H96_07565	COG0138	bifunctional purine biosynthesis protein purh
C2H96_07570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C2H96_07575	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
C2H96_07580	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C2H96_07585	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2H96_07590	COG0047	phosphoribosylformylglycinamidine synthase activity
C2H96_07595	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C2H96_07600	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
C2H96_07605	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C2H96_07610	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C2H96_07615	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C2H96_07625	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
C2H96_07635	COG3064	Membrane
C2H96_07640	COG2252	PERMEase
C2H96_07655	COG0518	GMP synthase (glutamine-hydrolyzing) activity
C2H96_07655	COG0519	Catalyzes the synthesis of GMP from XMP
C2H96_07660	COG1305	Transglutaminase-like
C2H96_07665	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
C2H96_07670	COG0714	Associated with various cellular activities
C2H96_07675	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2H96_07685	COG1113	amino acid transport
C2H96_07690	COG2132	Multicopper oxidase
C2H96_07700	COG2267	carboxylic ester hydrolase activity
C2H96_07715	COG0823	Involved in the tonB-independent uptake of proteins
C2H96_07720	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C2H96_07725	COG1063	alcohol dehydrogenase
C2H96_07730	COG2814	Major facilitator Superfamily
C2H96_07740	COG4260	virion core protein, lumpy skin disease virus
C2H96_07745	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C2H96_07750	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C2H96_07755	COG1842	Phage shock protein A
C2H96_07760	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H96_07765	COG2211	Major facilitator Superfamily
C2H96_07770	COG1063	alcohol dehydrogenase
C2H96_07775	COG0457	Tetratricopeptide repeat
C2H96_07780	COG1073	alpha beta
C2H96_07805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H96_07805	COG0072	phenylalanine-tRNA ligase activity
C2H96_07815	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H96_07845	COG0459	protein refolding
C2H96_07855	COG1266	CAAX protease self-immunity
C2H96_07870	COG0805	protein transport
C2H96_07875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2H96_07880	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
C2H96_07885	COG0315	cyclic pyranopterin monophosphate synthase activity
C2H96_07890	COG0488	(ABC) transporter
C2H96_07895	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
C2H96_07900	COG0456	acetyltransferase
C2H96_07905	COG1214	PFAM Peptidase M22, glycoprotease
C2H96_07910	COG0802	atpase or kinase
C2H96_07915	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C2H96_07960	COG4124	Belongs to the glycosyl hydrolase 26 family
C2H96_07965	COG1482	cell wall glycoprotein biosynthetic process
C2H96_07970	COG1940	carbohydrate kinase activity
C2H96_07975	COG2188	Transcriptional regulator
C2H96_07980	COG2723	6-phospho-beta-galactosidase activity
C2H96_07985	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H96_07990	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2H96_07995	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H96_08000	COG2814	Major facilitator Superfamily
C2H96_08005	COG1388	LysM domain
C2H96_08010	COG1078	dGTPase activity
C2H96_08015	COG0454	-acetyltransferase
C2H96_08025	COG5646	InterPro IPR014922
C2H96_08030	COG1785	Belongs to the alkaline phosphatase family
C2H96_08040	COG1819	glycosyl
C2H96_08045	COG1388	LysM domain
C2H96_08045	COG3858	chitin binding
C2H96_08050	COG1802	Transcriptional regulator
C2H96_08055	COG0730	response to heat
C2H96_08060	COG2814	Major facilitator Superfamily
C2H96_08065	COG1846	Transcriptional regulator
C2H96_08070	COG0778	Nitroreductase
C2H96_08075	COG2409	Drug exporters of the RND superfamily
C2H96_08075	COG1033	growth of symbiont in host cell
C2H96_08080	COG1846	Transcriptional regulator
C2H96_08085	COG2318	DinB family
C2H96_08090	COG1113	amino acid transport
C2H96_08095	COG0488	(ABC) transporter
C2H96_08100	COG0456	acetyltransferase
C2H96_08110	COG1309	transcriptional regulator
C2H96_08125	COG0071	Belongs to the small heat shock protein (HSP20) family
C2H96_08130	COG2323	membrane
C2H96_08150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H96_08155	COG2259	Doxx family
C2H96_08160	COG0346	lactoylglutathione lyase activity
C2H96_08165	COG0778	Nitroreductase
C2H96_08170	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2H96_08175	COG0789	Transcriptional regulator
C2H96_08175	COG4978	Transcriptional regulator
C2H96_08180	COG1811	Na channel or pump
C2H96_08185	COG2409	Drug exporters of the RND superfamily
C2H96_08190	COG2197	response regulator
C2H96_08195	COG4585	Histidine kinase
C2H96_08210	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2H96_08215	COG0640	Transcriptional regulator
C2H96_08220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2H96_08225	COG0076	glutamate decarboxylase activity
C2H96_08230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H96_08235	COG0697	spore germination
C2H96_08240	COG0745	RESPONSE REGULATOR receiver
C2H96_08245	COG5002	protein histidine kinase activity
C2H96_08260	COG1316	TRANSCRIPTIONal
C2H96_08265	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H96_08270	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2H96_08275	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2H96_08280	COG0640	Transcriptional regulator
C2H96_08285	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H96_08290	COG1733	regulation of RNA biosynthetic process
C2H96_08295	COG3545	Serine hydrolase
C2H96_08300	COG2030	dehydratase
C2H96_08305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H96_08310	COG0697	spore germination
C2H96_08325	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
C2H96_08335	COG0477	Major facilitator Superfamily
C2H96_08345	COG3708	Transcriptional regulator
C2H96_08345	COG2207	Transcriptional regulator
C2H96_08350	COG0697	spore germination
C2H96_08355	COG2207	Transcriptional regulator
C2H96_08355	COG1917	Cupin 2, conserved barrel domain protein
C2H96_08370	COG1329	Transcriptional regulator
C2H96_08375	COG1278	Cold shock
C2H96_08380	COG3239	Fatty acid desaturase
C2H96_08395	COG2814	Major facilitator Superfamily
C2H96_08400	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2H96_08405	COG1335	isochorismatase
C2H96_08410	COG1522	sequence-specific DNA binding
C2H96_08415	COG1522	sequence-specific DNA binding
C2H96_08420	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H96_08435	COG0457	Tetratricopeptide repeat
C2H96_08455	COG0791	NLP P60 protein
C2H96_08455	COG0741	lytic transglycosylase activity
C2H96_08460	COG5644	endopeptidase inhibitor activity
C2H96_08470	COG0433	COG0433 Predicted ATPase
C2H96_08505	COG2946	Replication initiation factor
C2H96_08510	COG1674	ftsk spoiiie
C2H96_08540	COG1396	sequence-specific DNA binding
C2H96_08545	COG2856	Zn peptidase
C2H96_08550	COG0582	viral genome integration into host DNA
C2H96_08590	COG3091	SprT-like family
C2H96_08600	COG2183	response to ionizing radiation
C2H96_08605	COG1846	Transcriptional regulator
C2H96_08610	COG1673	EVE domain
C2H96_08620	COG2208	phosphoserine phosphatase activity
C2H96_08625	COG1191	sigma factor activity
C2H96_08630	COG2172	sigma factor antagonist activity
C2H96_08635	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H96_08640	COG2208	phosphoserine phosphatase activity
C2H96_08645	COG2172	sigma factor antagonist activity
C2H96_08650	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H96_08655	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H96_08660	COG2337	Toxic component of a toxin-antitoxin (TA) module
C2H96_08665	COG0864	Transcriptional regulator
C2H96_08670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
C2H96_08675	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C2H96_08680	COG0736	holo-[acyl-carrier-protein] synthase activity
C2H96_08685	COG0705	Rhomboid family
C2H96_08690	COG3428	Bacterial PH domain
C2H96_08695	COG3402	PFAM membrane-flanked domain
C2H96_08700	COG0513	Belongs to the DEAD box helicase family
C2H96_08710	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C2H96_08715	COG1181	Belongs to the D-alanine--D-alanine ligase family
C2H96_08720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H96_08725	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C2H96_08740	COG1960	acyl-CoA dehydrogenase activity
C2H96_08750	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2H96_08755	COG1131	(ABC) transporter
C2H96_08760	COG0628	permease
C2H96_08765	COG1301	dicarboxylic acid transport
C2H96_08770	COG4565	transcriptional regulatory protein
C2H96_08775	COG3290	protein histidine kinase activity
C2H96_08780	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
C2H96_08785	COG3546	catalase activity
C2H96_08790	COG2329	Antibiotic biosynthesis monooxygenase
C2H96_08795	COG0662	Cupin 2, conserved barrel domain protein
C2H96_08800	COG3729	General stress protein
C2H96_08805	COG2217	Heavy metal translocating P-type atpase
C2H96_08810	COG4876	unkown
C2H96_08815	COG2261	transglycosylase associated protein
C2H96_08820	COG1914	H( )-stimulated, divalent metal cation uptake system
C2H96_08830	COG0028	Belongs to the TPP enzyme family
C2H96_08835	COG0494	nUDIX hydrolase
C2H96_08840	COG0531	amino acid
C2H96_08850	COG1215	transferase activity, transferring glycosyl groups
C2H96_08855	COG5298	Protein conserved in bacteria
C2H96_08860	COG3706	GGDEF domain
C2H96_08865	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
C2H96_08870	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C2H96_08870	COG0551	DNA topoisomerase type I activity
C2H96_08875	COG1522	sequence-specific DNA binding
C2H96_08880	COG2814	Major facilitator Superfamily
C2H96_08890	COG3871	stress protein (general stress protein 26)
C2H96_08895	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H96_08900	COG1917	Cupin 2, conserved barrel domain protein
C2H96_08905	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_08910	COG2226	methyltransferase
C2H96_08915	COG0318	PFAM AMP-dependent synthetase and ligase
C2H96_08920	COG3711	transcriptional antiterminator
C2H96_08925	COG4989	oxidoreductase activity
C2H96_08930	COG0768	penicillin binding
C2H96_08935	COG2329	Antibiotic biosynthesis monooxygenase
C2H96_08945	COG2755	lipolytic protein G-D-S-L family
C2H96_08950	COG1414	Transcriptional regulator
C2H96_08955	COG1984	allophanate hydrolase subunit 2
C2H96_08960	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
C2H96_08965	COG4336	lyase activity
C2H96_08970	COG1914	H( )-stimulated, divalent metal cation uptake system
C2H96_08975	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
C2H96_08980	COG0561	phosphatase activity
C2H96_08990	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2H96_08995	COG0412	Dienelactone hydrolase
C2H96_09000	COG0681	Belongs to the peptidase S26 family
C2H96_09005	COG0473	3-isopropylmalate dehydrogenase activity
C2H96_09010	COG0246	Mannitol dehydrogenase
C2H96_09015	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H96_09020	COG2213	PTS system mannitol-specific
C2H96_09030	COG1349	DNA-binding transcription factor activity
C2H96_09035	COG1276	copper resistance
C2H96_09035	COG2372	response to copper ion
C2H96_09040	COG4549	nuclear export factor GLE1
C2H96_09045	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_09050	COG4975	Glucose uptake
C2H96_09075	COG1012	belongs to the aldehyde dehydrogenase family
C2H96_09080	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C2H96_09085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H96_09090	COG0640	Transcriptional regulator
C2H96_09095	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
C2H96_09100	COG0778	Nitroreductase
C2H96_09105	COG1309	transcriptional regulator
C2H96_09110	COG2814	Major facilitator Superfamily
C2H96_09115	COG4607	ABC-type enterochelin transport system periplasmic component
C2H96_09120	COG4604	ABC transporter, ATP-binding protein
C2H96_09125	COG4605	iron ion homeostasis
C2H96_09130	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H96_09135	COG0527	aspartate kinase activity
C2H96_09155	COG0457	Tetratricopeptide repeat
C2H96_09160	COG3850	Histidine kinase
C2H96_09160	COG5002	protein histidine kinase activity
C2H96_09165	COG0745	RESPONSE REGULATOR receiver
C2H96_09170	COG0577	efflux transmembrane transporter activity
C2H96_09175	COG1136	(ABC) transporter
C2H96_09180	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2H96_09190	COG0697	spore germination
C2H96_09200	COG5434	Belongs to the glycosyl hydrolase 28 family
C2H96_09205	COG3104	oligopeptide transport
C2H96_09210	COG0596	Alpha beta hydrolase
C2H96_09225	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
C2H96_09230	COG0163	prenyltransferase activity
C2H96_09235	COG0583	DNA-binding transcription factor activity
C2H96_09240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H96_09245	COG0765	amino acid transport
C2H96_09250	COG1126	abc transporter atp-binding protein
C2H96_09255	COG2364	Membrane
C2H96_09265	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C2H96_09270	COG0697	spore germination
C2H96_09280	COG2814	Major facilitator Superfamily
C2H96_09285	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
C2H96_09290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H96_09295	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H96_09300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H96_09305	COG1733	regulation of RNA biosynthetic process
C2H96_09310	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
C2H96_09315	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
C2H96_09320	COG3290	protein histidine kinase activity
C2H96_09320	COG0840	transmembrane signaling receptor activity
C2H96_09325	COG3209	COG3209 Rhs family protein
C2H96_09335	COG2723	6-phospho-beta-galactosidase activity
C2H96_09340	COG3842	ATPase activity
C2H96_09350	COG1846	Transcriptional regulator
C2H96_09360	COG1714	RDD family
C2H96_09365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H96_09370	COG0765	amino acid transport
C2H96_09375	COG0523	cobalamin synthesis protein
C2H96_09395	COG1469	GTP cyclohydrolase I activity
C2H96_09400	COG2223	nitrite transmembrane transporter activity
C2H96_09405	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2H96_09410	COG0243	molybdopterin cofactor binding
C2H96_09415	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2H96_09420	COG2146	nitrite reductase [NAD(P)H] activity
C2H96_09425	COG1587	Uroporphyrinogen-III synthase
C2H96_09425	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C2H96_09430	COG0492	ferredoxin-NADP+ reductase activity
C2H96_09435	COG2267	carboxylic ester hydrolase activity
C2H96_09440	COG0701	Predicted permease
C2H96_09445	COG3689	TIGRFAM TIGR03943 family protein
C2H96_09450	COG2508	Transcriptional regulator
C2H96_09455	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H96_09460	COG1012	belongs to the aldehyde dehydrogenase family
C2H96_09465	COG0506	proline dehydrogenase activity
C2H96_09470	COG3541	Predicted nucleotidyltransferase
C2H96_09475	COG3458	cephalosporin-C deacetylase activity
C2H96_09480	COG0583	DNA-binding transcription factor activity
C2H96_09485	COG2226	methyltransferase
C2H96_09490	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C2H96_09495	COG1660	Displays ATPase and GTPase activities
C2H96_09500	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
C2H96_09505	COG3665	Urea carboxylase-associated protein
C2H96_09510	COG1113	amino acid transport
C2H96_09515	COG3403	YqcI/YcgG family
C2H96_09520	COG1280	lysine exporter protein (LysE YggA)
C2H96_09525	COG1846	Transcriptional regulator
C2H96_09530	COG2814	Major facilitator Superfamily
C2H96_09535	COG1620	l-lactate permease
C2H96_09540	COG0039	L-malate dehydrogenase activity
C2H96_09545	COG0366	Alpha amylase catalytic
C2H96_09555	COG1288	antiporter activity
C2H96_09560	COG1473	amidohydrolase
C2H96_09565	COG2113	Glycine betaine
C2H96_09570	COG4176	ABC-type proline glycine betaine transport system permease component
C2H96_09575	COG4175	Glycine betaine
C2H96_09575	COG0517	IMP dehydrogenase activity
C2H96_09580	COG0640	Transcriptional regulator
C2H96_09585	COG2814	Major facilitator Superfamily
C2H96_09595	COG0477	Major facilitator Superfamily
C2H96_09600	COG3853	Toxic anion resistance protein (TelA)
C2H96_09610	COG0861	Integral membrane protein TerC family
C2H96_09615	COG2310	stress, protein
C2H96_09620	COG2310	stress, protein
C2H96_09625	COG2310	stress, protein
C2H96_09630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H96_09635	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2H96_09640	COG1121	(ABC) transporter
C2H96_09645	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2H96_09650	COG0366	Alpha amylase catalytic
C2H96_09655	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_09660	COG0457	Tetratricopeptide repeat
C2H96_09665	COG1876	peptidase activity
C2H96_09670	COG1595	DNA-templated transcription, initiation
C2H96_09680	COG1595	DNA-templated transcription, initiation
C2H96_09690	COG0667	Aldo Keto reductase
C2H96_09695	COG1668	transmembrane transport
C2H96_09700	COG4555	ABC transporter
C2H96_09705	COG3279	Response regulator of the LytR AlgR family
C2H96_09710	COG3290	protein histidine kinase activity
C2H96_09715	COG3012	SEC-C Motif Domain Protein
C2H96_09715	COG1405	negative regulation of cell septum assembly
C2H96_09720	COG1714	RDD family
C2H96_09725	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
C2H96_09730	COG0252	asparaginase activity
C2H96_09735	COG1309	transcriptional regulator
C2H96_09740	COG0477	Major facilitator Superfamily
C2H96_09745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2H96_09750	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
C2H96_09755	COG0805	protein transport
C2H96_09760	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C2H96_09765	COG3540	Alkaline phosphatase
C2H96_09775	COG2304	oxidoreductase activity
C2H96_09780	COG3773	Cell wall hydrolase
C2H96_09795	COG1131	(ABC) transporter
C2H96_09800	COG2205	protein histidine kinase activity
C2H96_09805	COG0745	RESPONSE REGULATOR receiver
C2H96_09820	COG3173	Aminoglycoside phosphotransferase
C2H96_09825	COG2721	sulfolactate sulfo-lyase activity
C2H96_09830	COG2186	Transcriptional regulator
C2H96_09835	COG4948	Mandelate Racemase Muconate Lactonizing
C2H96_09840	COG2271	Major facilitator Superfamily
C2H96_09845	COG1012	belongs to the aldehyde dehydrogenase family
C2H96_09850	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C2H96_09860	COG0784	Response regulator, receiver
C2H96_09865	COG4191	Histidine kinase
C2H96_09870	COG2066	Belongs to the glutaminase family
C2H96_09875	COG1115	amino acid carrier protein
C2H96_09885	COG2040	homocysteine
C2H96_09890	COG0833	amino acid
C2H96_09895	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2H96_09905	COG2188	Transcriptional regulator
C2H96_09910	COG0363	glucosamine-6-phosphate deaminase activity
C2H96_09915	COG1263	PTS System
C2H96_09915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H96_09915	COG2190	(PTS) system
C2H96_09920	COG1301	dicarboxylic acid transport
C2H96_09925	COG1054	Belongs to the UPF0176 family
C2H96_09930	COG2312	Erythromycin esterase
C2H96_09940	COG0688	phosphatidylethanolamine metabolic process
C2H96_09945	COG0586	Pfam SNARE associated Golgi protein
C2H96_09950	COG1183	phosphatidylcholine synthase activity
C2H96_09955	COG0596	Alpha beta hydrolase
C2H96_09965	COG3591	Belongs to the peptidase S1B family
C2H96_09970	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
C2H96_09975	COG2207	Transcriptional regulator
C2H96_09975	COG1917	Cupin 2, conserved barrel domain protein
C2H96_09980	COG0697	spore germination
C2H96_09985	COG3409	Peptidoglycan-binding domain 1 protein
C2H96_09995	COG2271	Major facilitator Superfamily
C2H96_10000	COG0456	acetyltransferase
C2H96_10000	COG1846	Transcriptional regulator
C2H96_10015	COG2271	Major facilitator Superfamily
C2H96_10020	COG0584	glycerophosphoryl diester phosphodiesterase
C2H96_10025	COG0531	amino acid
C2H96_10035	COG2124	cytochrome p450
C2H96_10040	COG2602	Beta-lactamase
C2H96_10055	COG1113	amino acid transport
C2H96_10070	COG0515	serine threonine protein kinase
C2H96_10080	COG0642	Histidine kinase
C2H96_10085	COG0745	RESPONSE REGULATOR receiver
C2H96_10090	COG0596	Alpha beta hydrolase
C2H96_10105	COG2814	Major facilitator Superfamily
C2H96_10110	COG0640	Transcriptional regulator
C2H96_10115	COG5609	conserved protein (DUF2294)
C2H96_10125	COG0288	reversible hydration of carbon dioxide
C2H96_10130	COG3002	Belongs to the UPF0753 family
C2H96_10135	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2H96_10140	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C2H96_10145	COG2169	Transcriptional regulator
C2H96_10150	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
C2H96_10160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C2H96_10165	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C2H96_10170	COG4856	YbbR-like protein
C2H96_10175	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
C2H96_10180	COG5662	AntiSigma factor
C2H96_10185	COG1595	DNA-templated transcription, initiation
C2H96_10215	COG1683	Conserved Protein
C2H96_10220	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C2H96_10225	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
C2H96_10230	COG1737	Transcriptional regulator
C2H96_10235	COG1263	PTS System
C2H96_10235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H96_10240	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2H96_10245	COG1472	Belongs to the glycosyl hydrolase 3 family
C2H96_10250	COG3876	Protein conserved in bacteria
C2H96_10255	COG2207	Transcriptional regulator
C2H96_10255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H96_10260	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H96_10265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H96_10270	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H96_10275	COG2819	hydrolase of the alpha beta superfamily
C2H96_10280	COG0385	Bile acid
C2H96_10285	COG0659	secondary active sulfate transmembrane transporter activity
C2H96_10415	COG0726	polysaccharide deacetylase
C2H96_10420	COG2194	sulfuric ester hydrolase activity
C2H96_10430	COG0489	protein tyrosine kinase activity
C2H96_10435	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H96_10445	COG2226	methyltransferase
C2H96_10450	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
C2H96_10455	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
C2H96_10460	COG0101	tRNA pseudouridine synthase activity
C2H96_10465	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
C2H96_10470	COG1122	ATPase activity
C2H96_10475	COG1122	ATPase activity
C2H96_10480	COG0203	ribosomal protein L17
C2H96_10485	COG0202	RNA polymerase activity
C2H96_10490	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
C2H96_10495	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
C2H96_10500	COG0257	Belongs to the bacterial ribosomal protein bL36 family
C2H96_10510	COG2163	COG2163 Ribosomal protein L14E L6E L27E
C2H96_10515	COG0024	Methionine aminopeptidase
C2H96_10520	COG0563	adenylate kinase activity
C2H96_10525	COG0201	protein transport
C2H96_10530	COG0200	Binds to the 23S rRNA
C2H96_10540	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C2H96_10545	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
C2H96_10550	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C2H96_10555	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
C2H96_10565	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
C2H96_10575	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
C2H96_10580	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
C2H96_10590	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
C2H96_10610	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
C2H96_10620	COG0088	Forms part of the polypeptide exit tunnel
C2H96_10625	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
C2H96_10635	COG0596	Alpha beta hydrolase
C2H96_10640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
C2H96_10645	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
C2H96_10650	COG0049	tRNA binding
C2H96_10655	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
C2H96_10660	COG1358	cellular component organization or biogenesis
C2H96_10665	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C2H96_10670	COG0085	RNA polymerase activity
C2H96_10675	COG2813	Specifically methylates the guanine in position
C2H96_10685	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
C2H96_10690	COG0081	regulation of translation
C2H96_10700	COG0250	Participates in transcription elongation, termination and antitermination
C2H96_10705	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2H96_10715	COG1595	DNA-templated transcription, initiation
C2H96_10720	COG3688	RNA-binding protein containing a PIN domain
C2H96_10725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2H96_10730	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
C2H96_10735	COG0215	cysteine-tRNA ligase activity
C2H96_10740	COG1045	serine acetyltransferase
C2H96_10750	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C2H96_10755	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
C2H96_10760	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C2H96_10765	COG4956	integral membrane protein (PIN domain superfamily)
C2H96_10770	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
C2H96_10775	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
C2H96_10780	COG0542	response to heat
C2H96_10785	COG3869	Catalyzes the specific phosphorylation of arginine residues in
C2H96_10790	COG3880	PFAM UvrB UvrC protein
C2H96_10795	COG4463	regulation of RNA biosynthetic process
C2H96_10875	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C2H96_10880	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C2H96_10885	COG1396	sequence-specific DNA binding
C2H96_10890	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C2H96_10895	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
C2H96_10900	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C2H96_10905	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2H96_10910	COG0512	Glutamine amidotransferase of anthranilate synthase
C2H96_10915	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2H96_10920	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2H96_10925	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C2H96_10930	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C2H96_10935	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
C2H96_10940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C2H96_10945	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C2H96_10950	COG0037	tRNA processing
C2H96_10955	COG0515	serine threonine protein kinase
C2H96_10960	COG2304	oxidoreductase activity
C2H96_10965	COG2208	phosphoserine phosphatase activity
C2H96_10980	COG1098	S1 RNA binding domain
C2H96_10985	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C2H96_11000	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C2H96_11005	COG3956	TIGRFAM MazG family protein
C2H96_11010	COG2244	polysaccharide biosynthetic process
C2H96_11015	COG2002	toxin-antitoxin pair type II binding
C2H96_11020	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C2H96_11030	COG0193	aminoacyl-tRNA hydrolase activity
C2H96_11035	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
C2H96_11040	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C2H96_11045	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
C2H96_11050	COG2088	sporulation resulting in formation of a cellular spore
C2H96_11055	COG0251	oxidation-reduction process
C2H96_11060	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2H96_11065	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C2H96_11075	COG4466	Protein conserved in bacteria
C2H96_11085	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C2H96_11090	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C2H96_11095	COG3584	3D domain protein
C2H96_11095	COG3583	domain protein
C2H96_11100	COG0084	hydrolase, TatD family'
C2H96_11105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H96_11105	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H96_11110	COG2002	toxin-antitoxin pair type II binding
C2H96_11115	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C2H96_11120	COG2827	Endonuclease containing a URI domain
C2H96_11125	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
C2H96_11130	COG4467	Involved in initiation control of chromosome replication
C2H96_11135	COG1774	PSP1 C-terminal conserved region
C2H96_11140	COG0470	DNA polymerase III
C2H96_11145	COG1728	Protein conserved in bacteria
C2H96_11150	COG3870	Protein conserved in bacteria
C2H96_11155	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C2H96_11160	COG1982	Orn Lys Arg decarboxylase major
C2H96_11165	COG3853	Toxic anion resistance protein (TelA)
C2H96_11170	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
C2H96_11215	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
C2H96_11220	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
C2H96_11225	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C2H96_11235	COG0590	tRNA wobble adenosine to inosine editing
C2H96_11240	COG1335	isochorismatase
C2H96_11245	COG1388	LysM domain
C2H96_11245	COG3858	chitin binding
C2H96_11250	COG1428	Deoxynucleoside kinase
C2H96_11255	COG1428	Deoxynucleoside kinase
C2H96_11265	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
C2H96_11270	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
C2H96_11275	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
C2H96_11280	COG1686	Belongs to the peptidase S11 family
C2H96_11285	COG0516	GMP reductase activity
C2H96_11285	COG0517	IMP dehydrogenase activity
C2H96_11320	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C2H96_11325	COG0187	DNA topoisomerase II activity
C2H96_11335	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
C2H96_11340	COG2501	S4 domain
C2H96_11345	COG0592	DNA-directed DNA polymerase activity
C2H96_11350	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C2H96_11360	COG0594	ribonuclease P activity
C2H96_11365	COG0706	membrane insertase activity
C2H96_11370	COG1847	R3H domain protein
C2H96_11375	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C2H96_11380	COG0445	tRNA wobble uridine modification
C2H96_11385	COG0357	Ribosomal RNA small subunit methyltransferase G
C2H96_11390	COG1475	DNA binding
C2H96_11400	COG1192	Involved in chromosome partitioning
C2H96_11405	COG1475	DNA binding
C2H96_11415	COG3949	Membrane
C2H96_11420	COG4481	Protein conserved in bacteria
C2H96_11425	COG0243	molybdopterin cofactor binding
C2H96_11430	COG0012	GTP binding
C2H96_11435	COG0360	Binds together with S18 to 16S ribosomal RNA
C2H96_11440	COG0629	single-stranded DNA binding
C2H96_11445	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
C2H96_11450	COG0708	Exodeoxyribonuclease III
C2H96_11455	COG1609	Transcriptional regulator
C2H96_11460	COG0346	lactoylglutathione lyase activity
C2H96_11465	COG0110	maltose O-acetyltransferase activity
C2H96_11470	COG2814	Major facilitator Superfamily
C2H96_11470	COG0477	Major facilitator Superfamily
C2H96_11475	COG1266	CAAX protease self-immunity
C2H96_11480	COG1331	Highly conserved protein containing a thioredoxin domain
C2H96_11520	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2H96_11525	COG2315	Protein conserved in bacteria
C2H96_11530	COG0456	acetyltransferase
C2H96_11535	COG2364	Membrane
C2H96_11540	COG2153	protein acetylation
C2H96_11545	COG1846	Transcriptional regulator
C2H96_11550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H96_11560	COG4319	ketosteroid isomerase
C2H96_11575	COG2271	Major facilitator Superfamily
C2H96_11590	COG1227	inorganic diphosphatase activity
C2H96_11595	COG1733	regulation of RNA biosynthetic process
C2H96_11600	COG5577	PFAM Coat F domain
C2H96_11610	COG4241	membrane
C2H96_11615	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
C2H96_11620	COG0359	binds to the 23S rRNA
C2H96_11625	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C2H96_11630	COG2807	transmembrane transport
C2H96_11635	COG3093	addiction module antidote protein HigA
C2H96_11650	COG0305	Participates in initiation and elongation during chromosome replication
C2H96_11685	COG0745	RESPONSE REGULATOR receiver
C2H96_11690	COG5002	protein histidine kinase activity
C2H96_11695	COG4863	YycH protein
C2H96_11700	COG4853	Protein conserved in bacteria
C2H96_11705	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
C2H96_11710	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H96_11725	COG3829	transcription factor binding
C2H96_11730	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C2H96_11735	COG0833	amino acid
C2H96_11740	COG0010	Belongs to the arginase family
C2H96_11750	COG0457	Tetratricopeptide repeat
C2H96_11755	COG0456	acetyltransferase
C2H96_11760	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
C2H96_11780	COG1063	alcohol dehydrogenase
C2H96_11795	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
C2H96_11805	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
C2H96_11815	COG0535	radical SAM domain protein
C2H96_11820	COG1994	Peptidase M50
C2H96_11825	COG1131	(ABC) transporter
C2H96_11840	COG2188	Transcriptional regulator
C2H96_11850	COG2190	(PTS) system
C2H96_11855	COG2723	6-phospho-beta-galactosidase activity
C2H96_11865	COG3634	alkyl hydroperoxide reductase activity
C2H96_11870	COG0450	alkyl hydroperoxide reductase
C2H96_11875	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C2H96_11880	COG2610	gluconate transmembrane transporter activity
C2H96_11885	COG1070	Carbohydrate kinase
C2H96_11890	COG1802	Transcriptional regulator
C2H96_11895	COG1929	Belongs to the glycerate kinase type-1 family
C2H96_11900	COG5039	Polysaccharide pyruvyl transferase
C2H96_11905	COG1346	cytolysis
C2H96_11910	COG1380	Effector of murein hydrolase LrgA
C2H96_11915	COG1846	Transcriptional regulator
C2H96_11920	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_11925	COG1309	transcriptional regulator
C2H96_11930	COG1917	Cupin 2, conserved barrel domain protein
C2H96_11935	COG2311	Membrane
C2H96_11940	COG1714	RDD family
C2H96_11950	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C2H96_11960	COG1012	belongs to the aldehyde dehydrogenase family
C2H96_11965	COG1309	transcriptional regulator
C2H96_11970	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_11980	COG0326	Molecular chaperone. Has ATPase activity
C2H96_11985	COG2814	Major facilitator Superfamily
C2H96_12015	COG0667	Aldo Keto reductase
C2H96_12020	COG1349	DNA-binding transcription factor activity
C2H96_12025	COG1012	belongs to the aldehyde dehydrogenase family
C2H96_12035	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H96_12040	COG3962	Belongs to the TPP enzyme family
C2H96_12045	COG1082	Xylose isomerase domain protein TIM barrel
C2H96_12050	COG2814	Major facilitator Superfamily
C2H96_12055	COG0673	inositol 2-dehydrogenase activity
C2H96_12060	COG1082	Xylose isomerase domain protein TIM barrel
C2H96_12065	COG1082	Xylose isomerase domain protein TIM barrel
C2H96_12070	COG0191	fructose-bisphosphate aldolase activity
C2H96_12075	COG0745	RESPONSE REGULATOR receiver
C2H96_12080	COG2205	protein histidine kinase activity
C2H96_12085	COG1136	(ABC) transporter
C2H96_12090	COG0577	efflux transmembrane transporter activity
C2H96_12095	COG5294	Protein conserved in bacteria
C2H96_12100	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H96_12130	COG0561	phosphatase activity
C2H96_12135	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C2H96_12145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H96_12150	COG0456	acetyltransferase
C2H96_12155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H96_12160	COG0765	amino acid transport
C2H96_12165	COG1126	abc transporter atp-binding protein
C2H96_12170	COG1473	amidohydrolase
C2H96_12175	COG2079	MmgE PrpD family protein
C2H96_12180	COG3192	ethanolamine utilization protein
C2H96_12190	COG2390	Transcriptional regulator
C2H96_12195	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
C2H96_12200	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2H96_12205	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
C2H96_12210	COG0833	amino acid
C2H96_12215	COG0010	Belongs to the arginase family
C2H96_12220	COG1228	amidohydrolase
C2H96_12225	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
C2H96_12230	COG2986	histidine ammonia-lyase
C2H96_12240	COG3507	Belongs to the glycosyl hydrolase 43 family
C2H96_12250	COG0494	nUDIX hydrolase
C2H96_12270	COG5444	nuclease activity
C2H96_12305	COG2190	(PTS) system
C2H96_12305	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H96_12305	COG1263	PTS System
C2H96_12310	COG2723	6-phospho-beta-galactosidase activity
C2H96_12315	COG0589	response to stress
C2H96_12320	COG0697	spore germination
C2H96_12390	COG2755	lipolytic protein G-D-S-L family
C2H96_12390	COG3401	FG-GAP repeat protein
C2H96_12395	COG0513	Belongs to the DEAD box helicase family
C2H96_12400	COG2270	Major facilitator Superfamily
C2H96_12410	COG3711	transcriptional antiterminator
C2H96_12415	COG2273	Hydrolase Family 16
C2H96_12425	COG0753	catalase activity
C2H96_12425	COG0693	protein deglycase activity
C2H96_12440	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2H96_12445	COG0500	methyltransferase
C2H96_12455	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
C2H96_12460	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C2H96_12465	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_12470	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2H96_12475	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C2H96_12480	COG4894	glucomannan catabolic process
C2H96_12490	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2H96_12495	COG2197	response regulator
C2H96_12500	COG4585	Histidine kinase
C2H96_12510	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C2H96_12520	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H96_12525	COG1012	belongs to the aldehyde dehydrogenase family
C2H96_12530	COG2508	Transcriptional regulator
C2H96_12535	COG3842	ATPase activity
C2H96_12540	COG0726	polysaccharide deacetylase
C2H96_12550	COG0501	Belongs to the peptidase M48B family
C2H96_12555	COG3493	citrate carrier protein
C2H96_12560	COG1271	oxidase subunit
C2H96_12565	COG1294	oxidase, subunit
C2H96_12570	COG4988	ABC transporter
C2H96_12575	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C2H96_12580	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C2H96_12585	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
C2H96_12590	COG1595	DNA-templated transcription, initiation
C2H96_12615	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
C2H96_12620	COG2814	Major facilitator Superfamily
C2H96_12625	COG0753	catalase activity
C2H96_12630	COG2094	Belongs to the DNA glycosylase MPG family
C2H96_12640	COG3711	transcriptional antiterminator
C2H96_12640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H96_12645	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H96_12650	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H96_12655	COG1447	Phosphotransferase system cellobiose-specific component IIA
C2H96_12660	COG1486	melibiose metabolic process
C2H96_12665	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
C2H96_12670	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
C2H96_12675	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
C2H96_12680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C2H96_12685	COG1696	Membrane protein involved in D-alanine export
C2H96_12690	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H96_12705	COG1575	Belongs to the MenA family. Type 1 subfamily
C2H96_12710	COG2357	RelA SpoT domain protein
C2H96_12715	COG2234	aminopeptidase activity
C2H96_12720	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2H96_12725	COG1846	Transcriptional regulator
C2H96_12730	COG5522	Integral membrane protein (intg_mem_TP0381)
C2H96_12735	COG1442	glycosyl transferase family 8
C2H96_12740	COG3711	transcriptional antiterminator
C2H96_12745	COG1263	PTS System
C2H96_12745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H96_12750	COG1404	Belongs to the peptidase S8 family
C2H96_12755	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
C2H96_12765	COG0346	lactoylglutathione lyase activity
C2H96_12770	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C2H96_12775	COG4895	conserved protein (DUF2196)
C2H96_12780	COG2814	Major facilitator Superfamily
C2H96_12785	COG1346	cytolysis
C2H96_12790	COG1380	Effector of murein hydrolase LrgA
C2H96_12795	COG0583	DNA-binding transcription factor activity
C2H96_12800	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
C2H96_12805	COG0352	thiamine-phosphate diphosphorylase activity
C2H96_12810	COG0672	)-iron permease
C2H96_12815	COG2822	iron ion transport
C2H96_12820	COG2837	iron assimilation
C2H96_12825	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
C2H96_12830	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
C2H96_12835	COG3162	membrane
C2H96_12845	COG1309	transcriptional regulator
C2H96_12850	COG2246	polysaccharide biosynthetic process
C2H96_12855	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
C2H96_12860	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
C2H96_12865	COG2261	transglycosylase associated protein
C2H96_12870	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C2H96_12875	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C2H96_12880	COG1845	cytochrome c oxidase, subunit III
C2H96_12885	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C2H96_12895	COG0772	Belongs to the SEDS family
C2H96_12900	COG0778	Nitroreductase
C2H96_12905	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H96_12910	COG1404	Belongs to the peptidase S8 family
C2H96_12920	COG3711	transcriptional antiterminator
C2H96_12925	COG2116	formate transmembrane transporter activity
C2H96_12930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H96_12930	COG1263	PTS System
C2H96_12935	COG1621	beta-fructofuranosidase activity
C2H96_12945	COG0351	phosphomethylpyrimidine kinase
C2H96_12950	COG1216	Glycosyl transferase, family 2
C2H96_12955	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
C2H96_12960	COG1012	belongs to the aldehyde dehydrogenase family
C2H96_12970	COG2233	PERMEase
C2H96_12975	COG2363	Small membrane protein
C2H96_12990	COG0463	Glycosyl transferase, family 2
C2H96_12995	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
C2H96_13000	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2H96_13005	COG0456	acetyltransferase
C2H96_13010	COG2089	acid synthase
C2H96_13015	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
C2H96_13020	COG3980	spore coat polysaccharide biosynthesis protein
C2H96_13025	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
C2H96_13030	COG1088	dTDP-glucose 4,6-dehydratase activity
C2H96_13035	COG1091	dTDP-4-dehydrorhamnose reductase activity
C2H96_13040	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
C2H96_13050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2H96_13055	COG1012	belongs to the aldehyde dehydrogenase family
C2H96_13060	COG4187	Peptidase family M20/M25/M40
C2H96_13065	COG0833	amino acid
C2H96_13070	COG2814	Major facilitator Superfamily
C2H96_13075	COG0077	Prephenate dehydratase
C2H96_13080	COG1917	Cupin 2, conserved barrel domain protein
C2H96_13085	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_13090	COG0151	Belongs to the GarS family
C2H96_13095	COG2814	Major facilitator Superfamily
C2H96_13100	COG0436	Aminotransferase
C2H96_13105	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_13110	COG3253	May function as heme-dependent peroxidase
C2H96_13115	COG0280	phosphate acetyltransferase
C2H96_13120	COG0583	DNA-binding transcription factor activity
C2H96_13125	COG0095	Lipoate-protein ligase
C2H96_13130	COG0697	spore germination
C2H96_13140	COG4844	belongs to the
C2H96_13145	COG1078	dGTPase activity
C2H96_13150	COG3465	dGTPase activity
C2H96_13155	COG1959	2 iron, 2 sulfur cluster binding
C2H96_13160	COG0477	Major facilitator Superfamily
C2H96_13165	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2H96_13170	COG1846	Transcriptional regulator
C2H96_13175	COG1942	4-Oxalocrotonate Tautomerase
C2H96_13180	COG1994	Peptidase M50
C2H96_13195	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2H96_13200	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
C2H96_13205	COG0010	Belongs to the arginase family
C2H96_13215	COG1131	(ABC) transporter
C2H96_13245	COG0457	Tetratricopeptide repeat
C2H96_13255	COG3391	amine dehydrogenase activity
C2H96_13260	COG3391	amine dehydrogenase activity
C2H96_13270	COG0612	Peptidase, M16
C2H96_13275	COG0612	Peptidase, M16
C2H96_13280	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
C2H96_13285	COG1131	(ABC) transporter
C2H96_13295	COG0535	radical SAM domain protein
C2H96_13310	COG4506	Protein conserved in bacteria
C2H96_13315	COG0018	arginyl-trna synthetase
C2H96_13320	COG2223	nitrite transmembrane transporter activity
C2H96_13325	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2H96_13335	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C2H96_13345	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C2H96_13350	COG1140	nitrate reductase beta subunit
C2H96_13355	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C2H96_13360	COG2181	nitrate reductase activity
C2H96_13370	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2H96_13375	COG1132	(ABC) transporter
C2H96_13380	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C2H96_13390	COG4294	response to UV
C2H96_13395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2H96_13400	COG2181	nitrate reductase activity
C2H96_13400	COG0247	lactate metabolic process
C2H96_13405	COG1960	acyl-CoA dehydrogenase activity
C2H96_13410	COG3343	RNA polymerase activity
C2H96_13415	COG0504	CTP synthase activity
C2H96_13420	COG4821	SIS domain
C2H96_13425	COG2204	response regulator
C2H96_13430	COG0191	fructose-bisphosphate aldolase activity
C2H96_13435	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
C2H96_13440	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2H96_13445	COG1494	fructose-1,6-bisphosphatase
C2H96_13460	COG1435	thymidine kinase activity
C2H96_13465	COG0281	malic enzyme
C2H96_13470	COG0679	Auxin Efflux Carrier
C2H96_13475	COG0789	Transcriptional regulator
C2H96_13480	COG0346	lactoylglutathione lyase activity
C2H96_13485	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
C2H96_13490	COG2890	protein-(glutamine-N5) methyltransferase activity
C2H96_13510	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C2H96_13515	COG0009	L-threonylcarbamoyladenylate synthase
C2H96_13520	COG1971	Probably functions as a manganese efflux pump
C2H96_13525	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C2H96_13530	COG0698	ribose 5-phosphate isomerase
C2H96_13535	COG4475	Protein of unknown function (DUF436)
C2H96_13540	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
C2H96_13545	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
C2H96_13555	COG0356	it plays a direct role in the translocation of protons across the membrane
C2H96_13565	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C2H96_13570	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
C2H96_13575	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
C2H96_13580	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
C2H96_13585	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
C2H96_13590	COG0355	proton-transporting ATP synthase activity, rotational mechanism
C2H96_13600	COG4836	Membrane
C2H96_13610	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
C2H96_13615	COG2385	sporulation resulting in formation of a cellular spore
C2H96_13620	COG2304	oxidoreductase activity
C2H96_13630	COG2304	oxidoreductase activity
C2H96_13640	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
C2H96_13645	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
C2H96_13650	COG0457	Tetratricopeptide repeat
C2H96_13655	COG1994	Peptidase M50
C2H96_13660	COG3237	CsbD-like
C2H96_13675	COG0831	urea catabolic process
C2H96_13680	COG0832	Belongs to the urease beta subunit family
C2H96_13685	COG0804	urea catabolic process
C2H96_13690	COG1959	2 iron, 2 sulfur cluster binding
C2H96_13695	COG2910	NAD(P)H-binding
C2H96_13705	COG0789	Transcriptional regulator
C2H96_13710	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C2H96_13725	COG1247	-acetyltransferase
C2H96_13730	COG0739	heme binding
C2H96_13740	COG0671	phosphoesterase, PA-phosphatase related
C2H96_13745	COG0347	Belongs to the P(II) protein family
C2H96_13750	COG0004	ammonium transporteR
C2H96_13760	COG1335	isochorismatase
C2H96_13765	COG0477	Major facilitator Superfamily
C2H96_13770	COG1953	Uracil, thiamine, allantoin
C2H96_13775	COG3420	alginic acid biosynthetic process
C2H96_13785	COG2814	Major facilitator Superfamily
C2H96_13790	COG1846	Transcriptional regulator
C2H96_13800	COG1609	Transcriptional regulator
C2H96_13805	COG1077	Cell shape determining protein MreB Mrl
C2H96_13810	COG4786	Flagellar basal body rod
C2H96_13815	COG4786	Flagellar basal body rod
C2H96_13820	COG0457	Tetratricopeptide repeat
C2H96_13825	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
C2H96_13830	COG1970	mechanosensitive ion channel activity
C2H96_13835	COG2972	Histidine kinase
C2H96_13835	COG0745	RESPONSE REGULATOR receiver
C2H96_13840	COG3279	Response regulator of the LytR AlgR family
C2H96_13850	COG3764	Sortase (surface protein transpeptidase)
C2H96_13865	COG0629	single-stranded DNA binding
C2H96_13870	COG1349	DNA-binding transcription factor activity
C2H96_13875	COG0561	phosphatase activity
C2H96_13885	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2H96_13890	COG4715	Zinc finger, swim domain protein
C2H96_13900	COG3944	biosynthesis protein
C2H96_13905	COG0489	protein tyrosine kinase activity
C2H96_13910	COG4464	protein tyrosine phosphatase activity
C2H96_13915	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C2H96_13920	COG3878	Protein conserved in bacteria
C2H96_13940	COG5444	nuclease activity
C2H96_13955	COG2059	Chromate
C2H96_13960	COG2059	Chromate
C2H96_13965	COG1522	sequence-specific DNA binding
C2H96_13970	COG0405	Gamma-glutamyltransferase
C2H96_13980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C2H96_13990	COG5337	Spore coat protein CotH
C2H96_14005	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
C2H96_14010	COG0583	DNA-binding transcription factor activity
C2H96_14015	COG0028	Belongs to the TPP enzyme family
C2H96_14020	COG3527	Alpha-acetolactate decarboxylase
C2H96_14025	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2H96_14035	COG3103	Sh3 type 3 domain protein
C2H96_14040	COG1879	ABC-type sugar transport system periplasmic component
C2H96_14045	COG1172	Belongs to the binding-protein-dependent transport system permease family
C2H96_14050	COG1129	ABC transporter
C2H96_14055	COG1869	D-ribose catabolic process
C2H96_14060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H96_14065	COG1609	Transcriptional regulator
C2H96_14075	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
C2H96_14085	COG2843	Capsule synthesis protein
C2H96_14095	COG0791	NLP P60 protein
C2H96_14100	COG0561	phosphatase activity
C2H96_14105	COG1316	TRANSCRIPTIONal
C2H96_14110	COG2814	Major facilitator Superfamily
C2H96_14120	COG0814	amino acid
C2H96_14125	COG0697	spore germination
C2H96_14130	COG1482	cell wall glycoprotein biosynthetic process
C2H96_14135	COG4193	domain, Protein
C2H96_14175	COG1216	Glycosyl transferase, family 2
C2H96_14175	COG1442	glycosyl transferase family 8
C2H96_14180	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
C2H96_14185	COG1682	transport, permease protein
C2H96_14190	COG1134	teichoic acid transport
C2H96_14195	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2H96_14215	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
C2H96_14220	COG1316	TRANSCRIPTIONal
C2H96_14230	COG2385	sporulation resulting in formation of a cellular spore
C2H96_14230	COG2247	cell wall binding repeat
C2H96_14235	COG2247	cell wall binding repeat
C2H96_14235	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H96_14250	COG2244	polysaccharide biosynthetic process
C2H96_14255	COG0438	transferase activity, transferring glycosyl groups
C2H96_14255	COG0297	glycogen (starch) synthase activity
C2H96_14260	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C2H96_14265	COG3307	-O-antigen
C2H96_14270	COG3206	protein involved in exopolysaccharide biosynthesis
C2H96_14275	COG1215	transferase activity, transferring glycosyl groups
C2H96_14280	COG0438	transferase activity, transferring glycosyl groups
C2H96_14285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C2H96_14290	COG1316	TRANSCRIPTIONal
C2H96_14295	COG1739	Uncharacterized protein family UPF0029
C2H96_14300	COG4585	Histidine kinase
C2H96_14305	COG2197	response regulator
C2H96_14310	COG1307	EDD domain protein, DegV family
C2H96_14315	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
C2H96_14325	COG1040	competence protein
C2H96_14335	COG2747	anti-sigma28 factor FlgM
C2H96_14340	COG3418	PFAM FlgN family protein
C2H96_14345	COG4786	Flagellar basal body rod
C2H96_14345	COG1256	bacterial-type flagellum assembly
C2H96_14350	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2H96_14360	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
C2H96_14365	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
C2H96_14370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2H96_14375	COG1334	flagellar protein FlaG
C2H96_14380	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
C2H96_14385	COG1516	flagellar protein fliS
C2H96_14400	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C2H96_14405	COG0653	protein targeting
C2H96_14415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H96_14420	COG2010	Cytochrome c
C2H96_14425	COG2884	Cell division ATP-binding protein ftsE
C2H96_14430	COG2177	Part of the ABC transporter FtsEX involved in
C2H96_14435	COG0793	Belongs to the peptidase S41A family
C2H96_14435	COG3409	Peptidoglycan-binding domain 1 protein
C2H96_14445	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H96_14450	COG2814	Major facilitator Superfamily
C2H96_14455	COG1309	transcriptional regulator
C2H96_14460	COG0574	Belongs to the PEP-utilizing enzyme family
C2H96_14460	COG3848	Pyruvate phosphate dikinase
C2H96_14465	COG4897	Protein conserved in bacteria
C2H96_14470	COG0556	nucleotide-excision repair
C2H96_14475	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
C2H96_14480	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C2H96_14495	COG3595	metallopeptidase activity
C2H96_14500	COG1983	PspC domain protein
C2H96_14505	COG1950	PFAM Membrane protein of
C2H96_14510	COG2814	Major facilitator Superfamily
C2H96_14515	COG1846	Transcriptional regulator
C2H96_14525	COG2124	cytochrome p450
C2H96_14530	COG1846	Transcriptional regulator
C2H96_14535	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
C2H96_14540	COG2188	Transcriptional regulator
C2H96_14545	COG0363	glucosamine-6-phosphate deaminase activity
C2H96_14550	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C2H96_14555	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
C2H96_14560	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
C2H96_14565	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
C2H96_14570	COG0546	phosphoglycolate phosphatase activity
C2H96_14575	COG0110	maltose O-acetyltransferase activity
C2H96_14580	COG5297	Belongs to the glycosyl hydrolase family 6
C2H96_14585	COG4990	cell redox homeostasis
C2H96_14590	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
C2H96_14595	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
C2H96_14600	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C2H96_14605	COG0131	Imidazoleglycerol-phosphate dehydratase
C2H96_14610	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C2H96_14615	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
C2H96_14620	COG0107	imidazoleglycerol-phosphate synthase activity
C2H96_14625	COG0140	phosphoribosyl-ATP diphosphatase activity
C2H96_14625	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C2H96_14645	COG1132	(ABC) transporter
C2H96_14650	COG0457	Tetratricopeptide repeat
C2H96_14655	COG3883	PFAM NLP P60 protein
C2H96_14655	COG0791	NLP P60 protein
C2H96_14660	COG0492	ferredoxin-NADP+ reductase activity
C2H96_14665	COG1051	belongs to the nudix hydrolase family
C2H96_14670	COG1660	Displays ATPase and GTPase activities
C2H96_14675	COG0391	Required for morphogenesis under gluconeogenic growth conditions
C2H96_14680	COG1481	regulation of sporulation
C2H96_14685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H96_14690	COG2162	N-hydroxyarylamine O-acetyltransferase activity
C2H96_14700	COG0745	RESPONSE REGULATOR receiver
C2H96_14705	COG5002	protein histidine kinase activity
C2H96_14710	COG1136	(ABC) transporter
C2H96_14715	COG0577	efflux transmembrane transporter activity
C2H96_14720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C2H96_14725	COG0288	reversible hydration of carbon dioxide
C2H96_14730	COG0659	secondary active sulfate transmembrane transporter activity
C2H96_14735	COG1694	Mazg nucleotide pyrophosphohydrolase
C2H96_14740	COG1611	Belongs to the LOG family
C2H96_14745	COG1609	Transcriptional regulator
C2H96_14750	COG0366	Alpha amylase catalytic
C2H96_14755	COG2182	Extracellular solute-binding protein
C2H96_14760	COG1175	transmembrane transport
C2H96_14765	COG3833	ABC-type maltose transport systems, permease component
C2H96_14770	COG5521	maltodextrose utilization protein MalA
C2H96_14775	COG1554	hydrolase, family 65, central catalytic
C2H96_14780	COG0366	Alpha amylase catalytic
C2H96_14785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C2H96_14790	COG0740	serine-type endopeptidase activity
C2H96_14805	COG2076	Multidrug Resistance protein
C2H96_14810	COG2076	Multidrug Resistance protein
C2H96_14815	COG1309	transcriptional regulator
C2H96_14820	COG0531	amino acid
C2H96_14825	COG1621	beta-fructofuranosidase activity
C2H96_14830	COG1621	beta-fructofuranosidase activity
C2H96_14835	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
C2H96_14840	COG1794	racemase activity, acting on amino acids and derivatives
C2H96_14850	COG3479	Phenolic acid decarboxylase
C2H96_14860	COG2272	Belongs to the type-B carboxylesterase lipase family
C2H96_14865	COG1396	sequence-specific DNA binding
C2H96_14870	COG3944	biosynthesis protein
C2H96_14875	COG0489	protein tyrosine kinase activity
C2H96_14880	COG1086	Polysaccharide biosynthesis protein
C2H96_14885	COG0438	transferase activity, transferring glycosyl groups
C2H96_14890	COG1215	transferase activity, transferring glycosyl groups
C2H96_14895	COG0438	transferase activity, transferring glycosyl groups
C2H96_14905	COG1216	Glycosyl transferase, family 2
C2H96_14910	COG5039	Polysaccharide pyruvyl transferase
C2H96_14915	COG1216	Glycosyl transferase, family 2
C2H96_14920	COG2244	polysaccharide biosynthetic process
C2H96_14925	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
C2H96_14930	COG0110	maltose O-acetyltransferase activity
C2H96_14935	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
C2H96_14940	COG5039	Polysaccharide pyruvyl transferase
C2H96_14950	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C2H96_14955	COG1620	l-lactate permease
C2H96_14960	COG2186	Transcriptional regulator
C2H96_14965	COG1609	Transcriptional regulator
C2H96_14970	COG2182	Extracellular solute-binding protein
C2H96_14975	COG1175	transmembrane transport
C2H96_14980	COG3833	ABC-type maltose transport systems, permease component
C2H96_14985	COG1874	Beta-galactosidase
C2H96_14990	COG3867	Arabinogalactan endo-beta-1,4-galactanase
C2H96_14995	COG2208	phosphoserine phosphatase activity
C2H96_15000	COG0596	Alpha beta hydrolase
C2H96_15005	COG1131	(ABC) transporter
C2H96_15010	COG0842	Transport permease protein
C2H96_15015	COG4585	Histidine kinase
C2H96_15020	COG2197	response regulator
C2H96_15035	COG0247	lactate metabolic process
C2H96_15040	COG1139	Iron-sulfur cluster binding protein
C2H96_15045	COG1556	Lactate utilization protein
C2H96_15050	COG3858	chitin binding
C2H96_15055	COG1113	amino acid transport
C2H96_15060	COG0697	spore germination
C2H96_15065	COG0583	DNA-binding transcription factor activity
C2H96_15075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H96_15080	COG1609	Transcriptional regulator
C2H96_15090	COG2390	Transcriptional regulator
C2H96_15095	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2H96_15100	COG0126	phosphoglycerate kinase activity
C2H96_15105	COG0149	triose-phosphate isomerase activity
C2H96_15110	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
C2H96_15115	COG0148	phosphopyruvate hydratase activity
C2H96_15120	COG0456	acetyltransferase
C2H96_15125	COG4640	response to antibiotic
C2H96_15130	COG3064	Membrane
C2H96_15140	COG2095	MarC family integral membrane protein
C2H96_15145	COG1510	regulation of RNA biosynthetic process
C2H96_15150	COG0517	IMP dehydrogenase activity
C2H96_15150	COG1125	glycine betaine transport
C2H96_15155	COG1174	glycine betaine transport
C2H96_15160	COG1732	Glycine betaine
C2H96_15165	COG1174	glycine betaine transport
C2H96_15170	COG1510	regulation of RNA biosynthetic process
C2H96_15175	COG1125	glycine betaine transport
C2H96_15175	COG0517	IMP dehydrogenase activity
C2H96_15180	COG1174	glycine betaine transport
C2H96_15185	COG1732	Glycine betaine
C2H96_15190	COG1174	glycine betaine transport
C2H96_15195	COG0840	transmembrane signaling receptor activity
C2H96_15200	COG1733	regulation of RNA biosynthetic process
C2H96_15205	COG1396	sequence-specific DNA binding
C2H96_15210	COG1396	sequence-specific DNA binding
C2H96_15215	COG1476	TRANSCRIPTIONal
C2H96_15220	COG0596	Alpha beta hydrolase
C2H96_15225	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C2H96_15230	COG1647	Serine aminopeptidase, S33
C2H96_15235	COG0557	exoribonuclease II activity
C2H96_15240	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
C2H96_15250	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_15255	COG1309	transcriptional regulator
C2H96_15260	COG2076	Multidrug Resistance protein
C2H96_15270	COG1289	transmembrane transporter activity
C2H96_15275	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
C2H96_15280	COG0673	inositol 2-dehydrogenase activity
C2H96_15285	COG1937	Protein conserved in bacteria
C2H96_15290	COG2608	mercury ion transmembrane transporter activity
C2H96_15295	COG2217	Heavy metal translocating P-type atpase
C2H96_15300	COG2217	Heavy metal translocating P-type atpase
C2H96_15305	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C2H96_15310	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
C2H96_15315	COG2860	membrane
C2H96_15325	COG3973	AAA domain
C2H96_15330	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2H96_15335	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C2H96_15340	COG0025	NhaP-type Na H and K H
C2H96_15350	COG0656	L-ascorbic acid biosynthetic process
C2H96_15355	COG4149	molybdate abc transporter
C2H96_15360	COG0725	ABC transporter, periplasmic molybdate-binding protein
C2H96_15365	COG1910	domain protein
C2H96_15370	COG1368	sulfuric ester hydrolase activity
C2H96_15375	COG1988	membrane-bound metal-dependent
C2H96_15390	COG0531	amino acid
C2H96_15400	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H96_15405	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H96_15410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H96_15415	COG1120	ATPase activity
C2H96_15420	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C2H96_15425	COG1136	(ABC) transporter
C2H96_15430	COG0577	efflux transmembrane transporter activity
C2H96_15440	COG2140	Oxalate decarboxylase
C2H96_15450	COG1191	sigma factor activity
C2H96_15460	COG0745	RESPONSE REGULATOR receiver
C2H96_15465	COG2205	protein histidine kinase activity
C2H96_15470	COG3386	PFAM SMP-30 Gluconolaconase
C2H96_15475	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_15480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
C2H96_15485	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C2H96_15490	COG1120	ATPase activity
C2H96_15495	COG2096	Adenosyltransferase
C2H96_15500	COG2814	Major facilitator Superfamily
C2H96_15505	COG4758	membrane
C2H96_15510	COG1842	Phage shock protein A
C2H96_15515	COG3595	metallopeptidase activity
C2H96_15520	COG4758	membrane
C2H96_15525	COG4585	Histidine kinase
C2H96_15530	COG2197	response regulator
C2H96_15540	COG0814	amino acid
C2H96_15545	COG0697	spore germination
C2H96_15555	COG0114	fumarate hydratase activity
C2H96_15560	COG1309	transcriptional regulator
C2H96_15570	COG2770	Histidine kinase
C2H96_15570	COG2205	protein histidine kinase activity
C2H96_15575	COG0745	RESPONSE REGULATOR receiver
C2H96_15580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C2H96_15585	COG0783	Belongs to the Dps family
C2H96_15590	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_15605	COG1120	ATPase activity
C2H96_15615	COG0583	DNA-binding transcription factor activity
C2H96_15620	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_15625	COG1942	4-Oxalocrotonate Tautomerase
C2H96_15630	COG0477	Major facilitator Superfamily
C2H96_15635	COG1846	Transcriptional regulator
C2H96_15640	COG5577	PFAM Coat F domain
C2H96_15650	COG0506	proline dehydrogenase activity
C2H96_15660	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2H96_15660	COG1024	Enoyl-CoA hydratase
C2H96_15665	COG0183	Belongs to the thiolase family
C2H96_15670	COG1960	acyl-CoA dehydrogenase activity
C2H96_15675	COG1393	Belongs to the ArsC family
C2H96_15680	COG0509	glycine decarboxylation via glycine cleavage system
C2H96_15690	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
C2H96_15695	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H96_15705	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
C2H96_15710	COG2011	ABC-type metal ion transport system permease component
C2H96_15715	COG1464	Belongs to the NlpA lipoprotein family
C2H96_15720	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C2H96_15735	COG0396	ATPase activity
C2H96_15740	COG0719	Fe-S assembly protein
C2H96_15745	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C2H96_15750	COG0822	iron-sulfur transferase activity
C2H96_15755	COG0719	Fe-S assembly protein
C2H96_15760	COG0640	Transcriptional regulator
C2H96_15765	COG0346	lactoylglutathione lyase activity
C2H96_15780	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C2H96_15785	COG0322	excinuclease ABC activity
C2H96_15790	COG2222	sugar isomerase
C2H96_15795	COG1653	transport
C2H96_15800	COG1175	transmembrane transport
C2H96_15805	COG0395	ABC-type sugar transport system, permease component
C2H96_15810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H96_15815	COG2188	Transcriptional regulator
C2H96_15820	COG3842	ATPase activity
C2H96_15825	COG2356	endonuclease I
C2H96_15830	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2H96_15835	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
C2H96_15840	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
C2H96_15845	COG2068	MobA-Related Protein
C2H96_15850	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
C2H96_15855	COG1529	Aldehyde oxidase and xanthine dehydrogenase
C2H96_15860	COG2080	2 iron, 2 sulfur cluster binding
C2H96_15870	COG2351	hydroxyisourate hydrolase activity
C2H96_15875	COG3648	Uricase
C2H96_15875	COG3195	allantoin biosynthetic process
C2H96_15880	COG2233	PERMEase
C2H96_15885	COG2233	PERMEase
C2H96_15890	COG2508	Transcriptional regulator
C2H96_15895	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C2H96_15905	COG1801	Protein of unknown function DUF72
C2H96_15910	COG0730	response to heat
C2H96_15915	COG0737	Belongs to the 5'-nucleotidase family
C2H96_15920	COG3377	Domain of unknown function (DUF1805)
C2H96_15930	COG0739	heme binding
C2H96_15935	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
C2H96_15945	COG4470	Protein conserved in bacteria
C2H96_15950	COG2445	Protein of unknown function DUF86
C2H96_15955	COG0647	UMP catabolic process
C2H96_15960	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
C2H96_15965	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H96_15970	COG0460	homoserine dehydrogenase
C2H96_15975	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C2H96_15980	COG0083	homoserine kinase activity
C2H96_15985	COG4946	Tricorn protease homolog
C2H96_15985	COG1506	peptidase
C2H96_15985	COG0823	Involved in the tonB-independent uptake of proteins
C2H96_15990	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C2H96_15995	COG4837	Protein of unknown function (DUF1462)
C2H96_16000	COG1252	NADH dehydrogenase
C2H96_16005	COG4844	belongs to the
C2H96_16010	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
C2H96_16015	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
C2H96_16020	COG0316	Belongs to the HesB IscA family
C2H96_16025	COG0456	acetyltransferase
C2H96_16030	COG2808	Putative FMN-binding domain
C2H96_16035	COG0516	GMP reductase activity
C2H96_16045	COG0492	ferredoxin-NADP+ reductase activity
C2H96_16050	COG1252	NADH dehydrogenase
C2H96_16065	COG3584	3D domain protein
C2H96_16070	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
C2H96_16075	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C2H96_16080	COG2056	Na+-H+ antiporter family
C2H96_16085	COG1268	BioY protein
C2H96_16090	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C2H96_16095	COG2819	hydrolase of the alpha beta superfamily
C2H96_16100	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_16105	COG1169	isochorismate synthase
C2H96_16110	COG1021	2,3-dihydroxybenzoate-AMP ligase
C2H96_16115	COG3433	isochorismatase activity
C2H96_16115	COG1535	isochorismatase
C2H96_16120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C2H96_16125	COG3251	PFAM MbtH domain protein
C2H96_16130	COG5634	Uncharacterized conserved protein (DUF2278)
C2H96_16135	COG0686	Belongs to the AlaDH PNT family
C2H96_16140	COG2508	Transcriptional regulator
C2H96_16140	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
C2H96_16145	COG4842	Belongs to the WXG100 family
C2H96_16150	COG5417	Belongs to the EsaB family
C2H96_16155	COG4499	WXG100 protein secretion system (Wss), protein YukC
C2H96_16160	COG1674	ftsk spoiiie
C2H96_16160	COG0433	COG0433 Predicted ATPase
C2H96_16165	COG1511	domain protein
C2H96_16175	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_16180	COG1418	mRNA catabolic process
C2H96_16195	COG0628	permease
C2H96_16210	COG5506	Protein of unknown function (DUF1694)
C2H96_16215	COG1335	isochorismatase
C2H96_16220	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
C2H96_16225	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
C2H96_16240	COG0142	geranyltranstransferase activity
C2H96_16250	COG4585	Histidine kinase
C2H96_16255	COG2197	response regulator
C2H96_16260	COG2050	protein possibly involved in aromatic compounds catabolism
C2H96_16265	COG1320	monovalent cation:proton antiporter activity
C2H96_16270	COG2212	antiporter activity
C2H96_16275	COG1863	multisubunit Na H antiporter MnhE subunit
C2H96_16280	COG0651	ATP synthesis coupled electron transport
C2H96_16285	COG1006	Multisubunit Na H antiporter MnhC subunit
C2H96_16290	COG2111	Na H antiporter
C2H96_16295	COG2111	Na H antiporter
C2H96_16295	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C2H96_16305	COG3493	citrate carrier protein
C2H96_16310	COG1079	Belongs to the binding-protein-dependent transport system permease family
C2H96_16315	COG4603	Belongs to the binding-protein-dependent transport system permease family
C2H96_16320	COG3845	ABC transporter
C2H96_16325	COG1744	ABC transporter substrate-binding protein PnrA-like
C2H96_16330	COG4565	transcriptional regulatory protein
C2H96_16335	COG3290	protein histidine kinase activity
C2H96_16345	COG3011	Protein conserved in bacteria
C2H96_16350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2H96_16355	COG2814	Major facilitator Superfamily
C2H96_16365	COG5018	Exonuclease
C2H96_16375	COG2205	protein histidine kinase activity
C2H96_16380	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
C2H96_16390	COG2267	carboxylic ester hydrolase activity
C2H96_16395	COG1522	sequence-specific DNA binding
C2H96_16400	COG0436	Aminotransferase
C2H96_16405	COG1098	S1 RNA binding domain
C2H96_16410	COG2155	Conserved Protein
C2H96_16415	COG1979	alcohol dehydrogenase
C2H96_16420	COG1979	alcohol dehydrogenase
C2H96_16425	COG0166	Belongs to the GPI family
C2H96_16440	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C2H96_16455	COG2738	Putative neutral zinc metallopeptidase
C2H96_16460	COG1253	flavin adenine dinucleotide binding
C2H96_16465	COG0366	Alpha amylase catalytic
C2H96_16470	COG0432	Pfam Uncharacterised protein family UPF0047
C2H96_16485	COG0840	transmembrane signaling receptor activity
C2H96_16490	COG0840	transmembrane signaling receptor activity
C2H96_16495	COG0840	transmembrane signaling receptor activity
C2H96_16500	COG0840	transmembrane signaling receptor activity
C2H96_16510	COG3347	Dehydrogenase
C2H96_16510	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_16515	COG1349	DNA-binding transcription factor activity
C2H96_16520	COG1070	Carbohydrate kinase
C2H96_16525	COG3254	rhamnose metabolic process
C2H96_16530	COG4806	L-rhamnose isomerase
C2H96_16535	COG0673	inositol 2-dehydrogenase activity
C2H96_16540	COG0628	permease
C2H96_16545	COG1968	undecaprenyl-diphosphatase activity
C2H96_16555	COG5553	Cysteine dioxygenase type I
C2H96_16560	COG0477	Major facilitator Superfamily
C2H96_16565	COG1705	Flagellar rod assembly protein muramidase FlgJ
C2H96_16570	COG4682	membrane
C2H96_16575	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C2H96_16580	COG0569	domain protein
C2H96_16590	COG1510	regulation of RNA biosynthetic process
C2H96_16595	COG1012	belongs to the aldehyde dehydrogenase family
C2H96_16600	COG1454	alcohol dehydrogenase
C2H96_16610	COG2318	DinB family
C2H96_16615	COG1585	Membrane protein implicated in regulation of membrane protease activity
C2H96_16620	COG2268	Band 7 protein
C2H96_16625	COG1247	-acetyltransferase
C2H96_16630	COG3859	Proton-coupled thiamine transporter YuaJ
C2H96_16755	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
C2H96_16760	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2H96_16765	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
C2H96_16770	COG0297	glycogen (starch) synthase activity
C2H96_16775	COG0058	SHG alpha-glucan phosphorylase activity
C2H96_16780	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
C2H96_16785	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H96_16790	COG0438	transferase activity, transferring glycosyl groups
C2H96_16795	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H96_16805	COG0438	transferase activity, transferring glycosyl groups
C2H96_16810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H96_16815	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C2H96_16820	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C2H96_16825	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C2H96_16830	COG1169	isochorismate synthase
C2H96_16835	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
C2H96_16840	COG0596	Alpha beta hydrolase
C2H96_16845	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C2H96_16850	COG0318	PFAM AMP-dependent synthetase and ligase
C2H96_16855	COG4948	Mandelate Racemase Muconate Lactonizing
C2H96_16860	COG0803	Belongs to the bacterial solute-binding protein 9 family
C2H96_16865	COG1121	(ABC) transporter
C2H96_16870	COG1321	iron dependent repressor
C2H96_16870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2H96_16875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C2H96_16885	COG1294	oxidase, subunit
C2H96_16890	COG1271	oxidase subunit
C2H96_16895	COG0254	rRNA binding
C2H96_16900	COG0288	reversible hydration of carbon dioxide
C2H96_16905	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
C2H96_16910	COG1854	S-ribosylhomocysteine lyase activity
C2H96_16925	COG0783	Belongs to the Dps family
C2H96_16930	COG4824	toxin secretion phage lysis holin
C2H96_16935	COG0494	nUDIX hydrolase
C2H96_16940	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C2H96_16945	COG1116	anion transmembrane transporter activity
C2H96_16950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C2H96_16955	COG1506	peptidase
C2H96_16965	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
C2H96_16970	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C2H96_16975	COG0367	asparagine synthase
C2H96_16980	COG1113	amino acid transport
C2H96_16985	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
C2H96_16990	COG2267	carboxylic ester hydrolase activity
C2H96_17000	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
C2H96_17005	COG1242	4 iron, 4 sulfur cluster binding
C2H96_17015	COG1725	Transcriptional regulator
C2H96_17020	COG1131	(ABC) transporter
C2H96_17035	COG1136	(ABC) transporter
C2H96_17040	COG0577	efflux transmembrane transporter activity
C2H96_17045	COG0745	RESPONSE REGULATOR receiver
C2H96_17050	COG2205	protein histidine kinase activity
C2H96_17055	COG1136	(ABC) transporter
C2H96_17060	COG0577	efflux transmembrane transporter activity
C2H96_17065	COG2433	Pfam Transposase IS66
C2H96_17070	COG2814	Major facilitator Superfamily
C2H96_17080	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H96_17080	COG2202	Pas domain
C2H96_17090	COG0495	leucyl-tRNA aminoacylation
C2H96_17095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2H96_17100	COG1486	melibiose metabolic process
C2H96_17105	COG0395	ABC-type sugar transport system, permease component
C2H96_17110	COG1175	transmembrane transport
C2H96_17115	COG1653	transport
C2H96_17120	COG1609	Transcriptional regulator
C2H96_17125	COG1073	alpha beta
C2H96_17135	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C2H96_17140	COG0156	8-amino-7-oxononanoate synthase activity
C2H96_17150	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
C2H96_17155	COG2124	cytochrome p450
C2H96_17160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C2H96_17165	COG0395	ABC-type sugar transport system, permease component
C2H96_17170	COG1653	transport
C2H96_17175	COG2207	Transcriptional regulator
C2H96_17180	COG4209	transmembrane transport
C2H96_17185	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
C2H96_17190	COG1653	transport
C2H96_17195	COG0673	inositol 2-dehydrogenase activity
C2H96_17200	COG5578	integral membrane protein
C2H96_17210	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
C2H96_17215	COG2081	HI0933 family
C2H96_17220	COG2244	polysaccharide biosynthetic process
C2H96_17225	COG1187	pseudouridine synthase activity
C2H96_17230	COG1349	DNA-binding transcription factor activity
C2H96_17235	COG1131	(ABC) transporter
C2H96_17240	COG4473	ABC transporter
C2H96_17245	COG2252	PERMEase
C2H96_17250	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C2H96_17255	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2H96_17260	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C2H96_17270	COG1597	lipid kinase activity
C2H96_17275	COG1523	belongs to the glycosyl hydrolase 13 family
C2H96_17280	COG0510	thiamine kinase activity
C2H96_17290	COG0220	tRNA (guanine-N7-)-methyltransferase activity
C2H96_17295	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H96_17300	COG0281	malic enzyme
C2H96_17305	COG5584	Small secreted protein
C2H96_17310	COG1363	Peptidase, m42
C2H96_17320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H96_17325	COG4848	Belongs to the UPF0354 family
C2H96_17330	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H96_17335	COG1674	ftsk spoiiie
C2H96_17340	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
C2H96_17345	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
C2H96_17350	COG4980	gas vesicle protein
C2H96_17355	COG3118	belongs to the thioredoxin family
C2H96_17360	COG1605	Chorismate mutase
C2H96_17360	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
C2H96_17365	COG1609	Transcriptional regulator
C2H96_17370	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C2H96_17375	COG1360	Flagellar Motor Protein
C2H96_17380	COG0123	including yeast histone deacetylase and acetoin utilization protein
C2H96_17385	COG0517	IMP dehydrogenase activity
C2H96_17390	COG0454	-acetyltransferase
C2H96_17395	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2H96_17405	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
C2H96_17410	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
C2H96_17420	COG2199	diguanylate cyclase activity
C2H96_17420	COG2203	Gaf domain
C2H96_17425	COG1956	GAF domain-containing protein
C2H96_17430	COG1309	transcriptional regulator
C2H96_17435	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2H96_17440	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
C2H96_17445	COG1114	Component of the transport system for branched-chain amino acids
C2H96_17450	COG1104	cysteine desulfurase activity
C2H96_17455	COG0301	tRNA thio-modification
C2H96_17465	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C2H96_17470	COG1574	metal-dependent hydrolase with the TIM-barrel fold
C2H96_17475	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C2H96_17480	COG0616	signal peptide processing
C2H96_17485	COG1714	RDD family
C2H96_17495	COG3874	Sporulation protein YtfJ
C2H96_17500	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
C2H96_17505	COG0827	DNA restriction-modification system
C2H96_17515	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C2H96_17520	COG0521	Mo-molybdopterin cofactor biosynthetic process
C2H96_17525	COG0137	argininosuccinate synthase activity
C2H96_17530	COG0165	Argininosuccinate lyase
C2H96_17540	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_17545	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
C2H96_17550	COG0583	DNA-binding transcription factor activity
C2H96_17555	COG0454	-acetyltransferase
C2H96_17560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H96_17565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H96_17570	COG0765	amino acid transport
C2H96_17575	COG0765	amino acid transport
C2H96_17580	COG1126	abc transporter atp-binding protein
C2H96_17585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H96_17590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C2H96_17595	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C2H96_17600	COG0196	riboflavin kinase activity
C2H96_17605	COG1473	amidohydrolase
C2H96_17610	COG0730	response to heat
C2H96_17615	COG4109	DRTGG domain
C2H96_17625	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
C2H96_17645	COG0587	DNA-directed DNA polymerase activity
C2H96_17650	COG0281	malic enzyme
C2H96_17655	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
C2H96_17660	COG0825	malonyl-CoA metabolic process
C2H96_17665	COG0205	6-phosphofructokinase activity
C2H96_17670	COG0469	pyruvate kinase activity
C2H96_17675	COG3030	protein affecting phage T7 exclusion by the F plasmid
C2H96_17680	COG0628	permease
C2H96_17685	COG2707	UPF0756 membrane protein
C2H96_17690	COG0372	Belongs to the citrate synthase family
C2H96_17695	COG0538	isocitrate dehydrogenase activity
C2H96_17700	COG0039	L-malate dehydrogenase activity
C2H96_17710	COG0745	RESPONSE REGULATOR receiver
C2H96_17715	COG5002	protein histidine kinase activity
C2H96_17720	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2H96_17720	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C2H96_17725	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
C2H96_17730	COG1971	Probably functions as a manganese efflux pump
C2H96_17735	COG0237	dephospho-CoA kinase activity
C2H96_17740	COG0656	L-ascorbic acid biosynthetic process
C2H96_17745	COG2814	Major facilitator Superfamily
C2H96_17750	COG1733	regulation of RNA biosynthetic process
C2H96_17755	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C2H96_17760	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
C2H96_17765	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
C2H96_17770	COG3611	Membrane attachment protein
C2H96_17775	COG1484	DNA-dependent DNA replication
C2H96_17780	COG0398	Pfam SNARE associated Golgi protein
C2H96_17790	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
C2H96_17795	COG1011	Hydrolase
C2H96_17800	COG3275	phosphorelay sensor kinase activity
C2H96_17805	COG3279	Response regulator of the LytR AlgR family
C2H96_17810	COG1380	Effector of murein hydrolase LrgA
C2H96_17815	COG1346	cytolysis
C2H96_17825	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C2H96_17830	COG0291	Belongs to the bacterial ribosomal protein bL35 family
C2H96_17835	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
C2H96_17840	COG3326	Membrane
C2H96_17850	COG1363	Peptidase, m42
C2H96_17855	COG3507	Belongs to the glycosyl hydrolase 43 family
C2H96_17860	COG2160	L-arabinose isomerase activity
C2H96_17865	COG1069	ribulokinase activity
C2H96_17870	COG0235	Class ii aldolase
C2H96_17875	COG0647	UMP catabolic process
C2H96_17880	COG0371	Dehydrogenase
C2H96_17885	COG1653	transport
C2H96_17890	COG1175	transmembrane transport
C2H96_17895	COG0395	ABC-type sugar transport system, permease component
C2H96_17900	COG3534	alpha-L-arabinofuranosidase
C2H96_17905	COG1966	Carbon starvation protein
C2H96_17915	COG0346	lactoylglutathione lyase activity
C2H96_17920	COG0247	lactate metabolic process
C2H96_17925	COG0277	FAD linked oxidase domain protein
C2H96_17930	COG3835	regulator
C2H96_17940	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C2H96_17950	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C2H96_17955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C2H96_17955	COG0072	phenylalanine-tRNA ligase activity
C2H96_17960	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
C2H96_17965	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
C2H96_17970	COG1286	toxin biosynthetic process
C2H96_17975	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
C2H96_17975	COG1796	DNA polymerase
C2H96_17980	COG1193	negative regulation of DNA recombination
C2H96_17985	COG3766	membrane
C2H96_17990	COG0318	PFAM AMP-dependent synthetase and ligase
C2H96_17995	COG1309	transcriptional regulator
C2H96_18000	COG1024	Enoyl-CoA hydratase
C2H96_18005	COG2086	electron transfer activity
C2H96_18010	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C2H96_18015	COG3534	alpha-L-arabinofuranosidase
C2H96_18025	COG3118	belongs to the thioredoxin family
C2H96_18030	COG0322	excinuclease ABC activity
C2H96_18040	COG0527	aspartate kinase activity
C2H96_18045	COG1719	4-vinyl reductase, 4VR
C2H96_18050	COG2009	succinate dehydrogenase
C2H96_18055	COG1053	succinate dehydrogenase
C2H96_18060	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
C2H96_18065	COG0824	Thioesterase
C2H96_18070	COG2197	response regulator
C2H96_18075	COG1846	Transcriptional regulator
C2H96_18080	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2H96_18085	COG5401	PFAM Sporulation and spore germination
C2H96_18090	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
C2H96_18095	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C2H96_18100	COG0622	Phosphoesterase
C2H96_18110	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
C2H96_18120	COG0454	-acetyltransferase
C2H96_18130	COG0028	Belongs to the TPP enzyme family
C2H96_18135	COG0440	acetolactate synthase activity
C2H96_18140	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
C2H96_18145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C2H96_18150	COG0473	3-isopropylmalate dehydrogenase activity
C2H96_18155	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
C2H96_18160	COG0066	3-isopropylmalate dehydratase activity
C2H96_18165	COG0457	Tetratricopeptide repeat
C2H96_18165	COG1477	protein flavinylation
C2H96_18170	COG0544	peptidyl-prolyl cis-trans isomerase activity
C2H96_18175	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
C2H96_18180	COG0470	DNA polymerase III
C2H96_18180	COG1067	ATP-dependent peptidase activity
C2H96_18185	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C2H96_18190	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C2H96_18200	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
C2H96_18205	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2H96_18210	COG0181	hydroxymethylbilane synthase activity
C2H96_18215	COG1587	Uroporphyrinogen-III synthase
C2H96_18220	COG0113	porphobilinogen synthase activity
C2H96_18225	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
C2H96_18230	COG1388	LysM domain
C2H96_18235	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C2H96_18245	COG0525	valine-tRNA ligase activity
C2H96_18250	COG0285	dihydrofolate synthase activity
C2H96_18255	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
C2H96_18265	COG0424	maF-like protein
C2H96_18270	COG2003	Belongs to the UPF0758 family
C2H96_18275	COG1077	Cell shape determining protein MreB Mrl
C2H96_18285	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
C2H96_18290	COG0850	regulation of cytokinetic process
C2H96_18295	COG2894	cell division
C2H96_18300	COG0739	heme binding
C2H96_18305	COG1994	Peptidase M50
C2H96_18310	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C2H96_18315	COG2868	ribosomal protein
C2H96_18320	COG0211	Belongs to the bacterial ribosomal protein bL27 family
C2H96_18325	COG3290	protein histidine kinase activity
C2H96_18330	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
C2H96_18335	COG4492	Belongs to the UPF0735 family
C2H96_18340	COG0077	Prephenate dehydratase
C2H96_18345	COG1827	regulation of RNA biosynthetic process
C2H96_18350	COG1104	cysteine desulfurase activity
C2H96_18355	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
C2H96_18360	COG0157	Belongs to the NadC ModD family
C2H96_18365	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
C2H96_18370	COG1388	LysM domain
C2H96_18380	COG0217	transcriptional regulatory protein
C2H96_18385	COG1115	amino acid carrier protein
C2H96_18400	COG2112	serine threonine protein kinase
C2H96_18405	COG0673	inositol 2-dehydrogenase activity
C2H96_18410	COG2814	Major facilitator Superfamily
C2H96_18420	COG0632	four-way junction helicase activity
C2H96_18425	COG2255	four-way junction helicase activity
C2H96_18435	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
C2H96_18440	COG0343	queuine tRNA-ribosyltransferase activity
C2H96_18445	COG1862	Preprotein translocase
C2H96_18455	COG2323	membrane
C2H96_18460	COG2244	polysaccharide biosynthetic process
C2H96_18470	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2H96_18470	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
C2H96_18475	COG0490	domain, Protein
C2H96_18480	COG5416	Lipopolysaccharide assembly protein A domain
C2H96_18485	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
C2H96_18485	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
C2H96_18490	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
C2H96_18495	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
C2H96_18500	COG1490	D-aminoacyl-tRNA deacylase activity
C2H96_18505	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H96_18505	COG3103	Sh3 type 3 domain protein
C2H96_18505	COG4991	sh3 domain protein
C2H96_18515	COG0124	histidyl-tRNA synthetase
C2H96_18520	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
C2H96_18530	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
C2H96_18535	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C2H96_18540	COG1959	2 iron, 2 sulfur cluster binding
C2H96_18545	COG1104	cysteine desulfurase activity
C2H96_18550	COG0482	sulfurtransferase activity
C2H96_18555	COG0457	Tetratricopeptide repeat
C2H96_18560	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C2H96_18565	COG3881	PFAM PRC-barrel domain
C2H96_18580	COG0765	amino acid transport
C2H96_18585	COG0765	amino acid transport
C2H96_18590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H96_18595	COG1126	abc transporter atp-binding protein
C2H96_18600	COG0628	permease
C2H96_18605	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C2H96_18610	COG4472	Bacterial protein of unknown function (DUF965)
C2H96_18615	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
C2H96_18620	COG3906	Belongs to the UPF0473 family
C2H96_18625	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2H96_18630	COG4122	O-methyltransferase activity
C2H96_18635	COG0826	peptidase U32
C2H96_18640	COG0826	peptidase U32
C2H96_18645	COG0572	uridine kinase
C2H96_18650	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C2H96_18655	COG0768	penicillin binding
C2H96_18670	COG2226	methyltransferase
C2H96_18675	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C2H96_18680	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C2H96_18685	COG0626	cystathionine gamma-synthase activity
C2H96_18695	COG2427	Protein of unknown function (DUF1641)
C2H96_18700	COG3383	formate dehydrogenase (NAD+) activity
C2H96_18705	COG5609	conserved protein (DUF2294)
C2H96_18710	COG2116	formate transmembrane transporter activity
C2H96_18720	COG2226	methyltransferase
C2H96_18725	COG1309	transcriptional regulator
C2H96_18730	COG2124	cytochrome p450
C2H96_18730	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C2H96_18740	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
C2H96_18740	COG2755	lipolytic protein G-D-S-L family
C2H96_18750	COG1595	DNA-templated transcription, initiation
C2H96_18755	COG1378	Sugar-specific transcriptional regulator TrmB
C2H96_18760	COG1280	lysine exporter protein (LysE YggA)
C2H96_18765	COG1113	amino acid transport
C2H96_18770	COG3933	PFAM sigma-54 factor interaction domain-containing protein
C2H96_18770	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
C2H96_18775	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C2H96_18780	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C2H96_18785	COG3715	PTS system
C2H96_18790	COG3716	PTS system mannose fructose sorbose family IID component
C2H96_18795	COG1621	beta-fructofuranosidase activity
C2H96_18800	COG0693	protein deglycase activity
C2H96_18805	COG1064	alcohol dehydrogenase
C2H96_18815	COG0789	Transcriptional regulator
C2H96_18820	COG5577	PFAM Coat F domain
C2H96_18830	COG1063	alcohol dehydrogenase
C2H96_18835	COG5577	PFAM Coat F domain
C2H96_18845	COG0346	lactoylglutathione lyase activity
C2H96_18850	COG4991	sh3 domain protein
C2H96_18855	COG4991	sh3 domain protein
C2H96_18860	COG0596	Alpha beta hydrolase
C2H96_18865	COG5566	PFAM Mor transcription activator
C2H96_18870	COG3409	Peptidoglycan-binding domain 1 protein
C2H96_18875	COG2828	Protein conserved in bacteria
C2H96_18880	COG0583	DNA-binding transcription factor activity
C2H96_18885	COG2851	Citrate transporter
C2H96_18890	COG0667	Aldo Keto reductase
C2H96_18895	COG1595	DNA-templated transcription, initiation
C2H96_18900	COG3443	Belongs to the bacterial solute-binding protein 9 family
C2H96_18915	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
C2H96_18930	COG2070	2-Nitropropane dioxygenase
C2H96_18940	COG2318	DinB family
C2H96_18960	COG1335	isochorismatase
C2H96_18970	COG2124	cytochrome p450
C2H96_18975	COG1522	sequence-specific DNA binding
C2H96_18980	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C2H96_18985	COG1687	branched-chain amino acid
C2H96_18990	COG1114	Component of the transport system for branched-chain amino acids
C2H96_19000	COG1230	cation diffusion facilitator family transporter
C2H96_19005	COG2072	flavoprotein involved in K transport
C2H96_19010	COG0583	DNA-binding transcription factor activity
C2H96_19015	COG0697	spore germination
C2H96_19025	COG1253	flavin adenine dinucleotide binding
C2H96_19030	COG0456	acetyltransferase
C2H96_19035	COG2814	Major facilitator Superfamily
C2H96_19040	COG4978	Transcriptional regulator
C2H96_19040	COG0789	Transcriptional regulator
C2H96_19060	COG0662	Cupin 2, conserved barrel domain protein
C2H96_19075	COG1937	Protein conserved in bacteria
C2H96_19080	COG2210	Belongs to the sulfur carrier protein TusA family
C2H96_19085	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2H96_19085	COG0425	Belongs to the sulfur carrier protein TusA family
C2H96_19095	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2H96_19095	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H96_19100	COG0425	Belongs to the sulfur carrier protein TusA family
C2H96_19105	COG0730	response to heat
C2H96_19115	COG2249	NAD(P)H dehydrogenase (quinone) activity
C2H96_19120	COG0454	-acetyltransferase
C2H96_19125	COG2311	Membrane
C2H96_19130	COG0745	RESPONSE REGULATOR receiver
C2H96_19135	COG5002	protein histidine kinase activity
C2H96_19135	COG0642	Histidine kinase
C2H96_19140	COG3223	Belongs to the PsiE family
C2H96_19145	COG1819	glycosyl
C2H96_19155	COG0583	DNA-binding transcription factor activity
C2H96_19160	COG0114	fumarate hydratase activity
C2H96_19175	COG2856	Zn peptidase
C2H96_19185	COG3620	sequence-specific DNA binding
C2H96_19190	COG1476	TRANSCRIPTIONal
C2H96_19215	COG5377	YqaJ viral recombinase family
C2H96_19220	COG3723	Recombinational DNA repair protein, rece pathway
C2H96_19225	COG3935	DnaD domain protein
C2H96_19230	COG1484	DNA-dependent DNA replication
C2H96_19240	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
C2H96_19255	COG3677	Transposase
C2H96_19285	COG5484	DNA packaging
C2H96_19290	COG1783	phage Terminase large subunit
C2H96_19295	COG5518	Phage portal protein
C2H96_19300	COG2369	cell adhesion
C2H96_19310	COG0338	D12 class N6 adenine-specific DNA methyltransferase
C2H96_19315	COG4653	Phage capsid family
C2H96_19375	COG3953	SLT domain
C2H96_19375	COG5280	Phage tail tape measure protein TP901
C2H96_19380	COG1652	LysM domain
C2H96_19385	COG4193	domain, Protein
C2H96_19395	COG3628	GPW Gp25 family protein
C2H96_19400	COG3299	homolog of phage Mu protein gp47
C2H96_19405	COG3778	Protein conserved in bacteria
C2H96_19435	COG4824	toxin secretion phage lysis holin
C2H96_19440	COG3409	Peptidoglycan-binding domain 1 protein
C2H96_19440	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2H96_19450	COG4282	regulation of fungal-type cell wall biogenesis
C2H96_19470	COG5444	nuclease activity
C2H96_19485	COG0457	Tetratricopeptide repeat
C2H96_19490	COG0546	phosphoglycolate phosphatase activity
C2H96_19500	COG0758	DNA mediated transformation
C2H96_19505	COG0457	Tetratricopeptide repeat
C2H96_19525	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C2H96_19535	COG3209	COG3209 Rhs family protein
C2H96_19545	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
C2H96_19550	COG0398	Pfam SNARE associated Golgi protein
C2H96_19555	COG3409	Peptidoglycan-binding domain 1 protein
C2H96_19555	COG5632	N-Acetylmuramoyl-L-alanine amidase
C2H96_19560	COG2755	lipolytic protein G-D-S-L family
C2H96_19570	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
C2H96_19575	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
C2H96_19580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C2H96_19585	COG1534	Rna-binding protein
C2H96_19590	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
C2H96_19595	COG1713	HD superfamily hydrolase involved in NAD metabolism
C2H96_19600	COG0799	negative regulation of ribosome biogenesis
C2H96_19605	COG2226	methyltransferase
C2H96_19610	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2H96_19615	COG1555	photosystem II stabilization
C2H96_19615	COG1596	polysaccharide export
C2H96_19620	COG2131	deaminase
C2H96_19625	COG0658	competence protein
C2H96_19625	COG2333	competence protein COMEC
C2H96_19635	COG1466	dna polymerase III delta subunit
C2H96_19640	COG0268	Binds directly to 16S ribosomal RNA
C2H96_19645	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
C2H96_19650	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H96_19660	COG0481	GTPase activity
C2H96_19665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C2H96_19670	COG1420	regulation of RNA biosynthetic process
C2H96_19675	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C2H96_19680	COG0443	Heat shock 70 kDa protein
C2H96_19685	COG0484	heat shock protein binding
C2H96_19690	COG2264	protein methyltransferase activity
C2H96_19695	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C2H96_19700	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C2H96_19705	COG1283	sodium-dependent phosphate transmembrane transporter activity
C2H96_19715	COG1610	YqeY-like protein
C2H96_19720	COG1030	water channel activity
C2H96_19725	COG4864	UPF0365 protein
C2H96_19740	COG0561	phosphatase activity
C2H96_19745	COG1702	phosphate starvation-inducible protein PhoH
C2H96_19750	COG1480	7TM receptor with intracellular HD hydrolase
C2H96_19755	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
C2H96_19760	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C2H96_19765	COG0295	cytidine deaminase activity
C2H96_19770	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
C2H96_19780	COG1381	Involved in DNA repair and RecF pathway recombination
C2H96_19785	COG0752	glycyl-tRNA synthetase alpha subunit
C2H96_19790	COG0751	glycine-tRNA ligase activity
C2H96_19795	COG0517	IMP dehydrogenase activity
C2H96_19800	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
C2H96_19805	COG1671	Belongs to the UPF0178 family
C2H96_19810	COG0358	DNA primase activity
C2H96_19815	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C2H96_19825	COG2010	Cytochrome c
C2H96_19830	COG2384	SAM-dependent methyltransferase
C2H96_19835	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C2H96_19840	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
C2H96_19850	COG0513	Belongs to the DEAD box helicase family
C2H96_19855	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
C2H96_19865	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H96_19870	COG0735	belongs to the Fur family
C2H96_19875	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
C2H96_19880	COG4709	membrane
C2H96_19885	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C2H96_19890	COG1388	LysM domain
C2H96_19900	COG5521	maltodextrose utilization protein MalA
C2H96_19905	COG2839	Protein conserved in bacteria
C2H96_19910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C2H96_19915	COG0477	Major facilitator Superfamily
C2H96_19920	COG0768	penicillin binding
C2H96_19925	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C2H96_19930	COG0573	inorganic phosphate transmembrane transporter activity
C2H96_19935	COG0581	inorganic phosphate transmembrane transporter activity
C2H96_19940	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2H96_19945	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C2H96_19950	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C2H96_19965	COG0438	transferase activity, transferring glycosyl groups
C2H96_19975	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
C2H96_19985	COG0457	Tetratricopeptide repeat
C2H96_19985	COG0705	Rhomboid family
C2H96_19990	COG4483	Protein conserved in bacteria
C2H96_19995	COG1940	carbohydrate kinase activity
C2H96_20000	COG1368	sulfuric ester hydrolase activity
C2H96_20005	COG2866	Carboxypeptidase
C2H96_20015	COG0011	TIGRFAM Protein of
C2H96_20025	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H96_20035	COG1393	Belongs to the ArsC family
C2H96_20045	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H96_20050	COG1253	flavin adenine dinucleotide binding
C2H96_20055	COG0598	Magnesium transport protein CorA
C2H96_20065	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
C2H96_20070	COG1459	type II secretion system
C2H96_20075	COG4537	Required for transformation and DNA binding
C2H96_20080	COG4970	Tfp pilus assembly protein FimT
C2H96_20090	COG4940	Competence protein ComGF
C2H96_20115	COG0681	Belongs to the peptidase S26 family
C2H96_20125	COG1396	sequence-specific DNA binding
C2H96_20145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
C2H96_20150	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C2H96_20155	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2H96_20160	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
C2H96_20165	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C2H96_20170	COG0095	Lipoate-protein ligase
C2H96_20175	COG1321	iron dependent repressor
C2H96_20180	COG1752	Esterase of the alpha-beta hydrolase superfamily
C2H96_20190	COG3872	metal-dependent enzyme
C2H96_20200	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
C2H96_20205	COG0006	proline dipeptidase activity
C2H96_20210	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C2H96_20220	COG3854	ATPases associated with a variety of cellular activities
C2H96_20260	COG0511	ligase activity, forming carbon-carbon bonds
C2H96_20265	COG0439	Biotin carboxylase
C2H96_20270	COG1302	Protein conserved in bacteria
C2H96_20275	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C2H96_20280	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C2H96_20285	COG1570	exodeoxyribonuclease VII activity
C2H96_20290	COG1722	exodeoxyribonuclease VII activity
C2H96_20295	COG0142	geranyltranstransferase activity
C2H96_20300	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
C2H96_20305	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C2H96_20310	COG1438	arginine binding
C2H96_20315	COG0497	DNA recombination
C2H96_20320	COG0750	zinc metalloprotease
C2H96_20330	COG0745	RESPONSE REGULATOR receiver
C2H96_20335	COG1902	pentaerythritol trinitrate reductase activity
C2H96_20345	COG0860	N-Acetylmuramoyl-L-alanine amidase
C2H96_20350	COG0584	glycerophosphoryl diester phosphodiesterase
C2H96_20355	COG0183	Belongs to the thiolase family
C2H96_20360	COG1250	3-hydroxyacyl-CoA dehydrogenase
C2H96_20370	COG0372	Belongs to the citrate synthase family
C2H96_20375	COG2079	MmgE PrpD family protein
C2H96_20380	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
C2H96_20390	COG3290	protein histidine kinase activity
C2H96_20390	COG3829	transcription factor binding
C2H96_20395	COG0280	phosphate acetyltransferase
C2H96_20400	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2H96_20405	COG3426	butyrate kinase activity
C2H96_20410	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C2H96_20415	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C2H96_20420	COG0022	dehydrogenase e1 component
C2H96_20425	COG0508	dehydrogenase complex catalyzes the overall conversion of
C2H96_20430	COG0789	Transcriptional regulator
C2H96_20430	COG4978	Transcriptional regulator
C2H96_20435	COG2814	Major facilitator Superfamily
C2H96_20440	COG1597	lipid kinase activity
C2H96_20450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C2H96_20455	COG0765	amino acid transport
C2H96_20460	COG1126	abc transporter atp-binding protein
C2H96_20465	COG4129	membrane
C2H96_20470	COG1376	ErfK ybiS ycfS ynhG family protein
C2H96_20475	COG0346	lactoylglutathione lyase activity
C2H96_20480	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C2H96_20485	COG2195	Cleaves the N-terminal amino acid of tripeptides
C2H96_20490	COG3361	conserved protein (COG2071)
C2H96_20495	COG0706	membrane insertase activity
C2H96_20505	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2H96_20510	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C2H96_20515	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C2H96_20520	COG1234	tRNA 3'-trailer cleavage
C2H96_20530	COG0596	Alpha beta hydrolase
C2H96_20535	COG1902	pentaerythritol trinitrate reductase activity
C2H96_20540	COG4187	Peptidase family M20/M25/M40
C2H96_20545	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
C2H96_20550	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C2H96_20555	COG0300	oxidoreductase activity
C2H96_20560	COG3048	D-serine ammonia-lyase activity
C2H96_20565	COG1072	(Pantothenic acid kinase))
C2H96_20570	COG0346	lactoylglutathione lyase activity
C2H96_20580	COG2211	Major facilitator Superfamily
C2H96_20590	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C2H96_20600	COG0456	acetyltransferase
C2H96_20605	COG2329	Antibiotic biosynthesis monooxygenase
C2H96_20610	COG0456	acetyltransferase
C2H96_20610	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
C2H96_20615	COG4918	Iron-sulphur cluster biosynthesis
C2H96_20625	COG1073	alpha beta
C2H96_20635	COG0667	Aldo Keto reductase
C2H96_20645	COG0494	nUDIX hydrolase
C2H96_20650	COG1379	DNA repair
C2H96_20655	COG1396	sequence-specific DNA binding
C2H96_20660	COG0252	asparaginase activity
C2H96_20665	COG1027	Aspartate ammonia-lyase
C2H96_20670	COG1757	Na H antiporter
C2H96_20675	COG0281	malic enzyme
C2H96_20685	COG1300	Membrane
C2H96_20690	COG0735	belongs to the Fur family
C2H96_20700	COG4974	Belongs to the 'phage' integrase family
C2H96_20705	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
C2H96_20710	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
C2H96_20715	COG1686	Belongs to the peptidase S11 family
C2H96_20720	COG1366	Belongs to the anti-sigma-factor antagonist family
C2H96_20725	COG2172	sigma factor antagonist activity
C2H96_20730	COG1191	sigma factor activity
C2H96_20750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C2H96_20765	COG0697	spore germination
C2H96_20770	COG0019	diaminopimelate decarboxylase activity
C2H96_20775	COG4086	secreted protein
C2H96_20785	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
C2H96_20795	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
C2H96_20800	COG0681	Belongs to the peptidase S26 family
C2H96_20810	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2H96_20810	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C2H96_20815	COG0307	riboflavin synthase, alpha
C2H96_20820	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2H96_20820	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C2H96_20825	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
C2H96_20830	COG0456	acetyltransferase
C2H96_20835	COG1547	Domain of unknown function (DUF309)
C2H96_20840	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C2H96_20845	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C2H96_20855	COG1686	Belongs to the peptidase S11 family
C2H96_20860	COG2715	membrane protein required for spore maturation
C2H96_20865	COG0700	Nucleoside recognition
C2H96_20870	COG1187	pseudouridine synthase activity
C2H96_20875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C2H96_20880	COG1333	cytochrome c biogenesis protein
C2H96_20885	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C2H96_20890	COG0745	RESPONSE REGULATOR receiver
C2H96_20895	COG5002	protein histidine kinase activity
C2H96_20900	COG1595	DNA-templated transcription, initiation
C2H96_20910	COG0710	3-dehydroquinate dehydratase activity
C2H96_20915	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C2H96_20920	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
C2H96_20925	COG1141	Ferredoxin
C2H96_20930	COG4955	Helix-turn-helix domain
C2H96_20935	COG0514	ATP-dependent DNA helicase (RecQ)
C2H96_20940	COG1266	CAAX protease self-immunity
C2H96_20945	COG1388	LysM domain
C2H96_20955	COG1408	metallophosphoesterase
C2H96_20960	COG4862	establishment of competence for transformation
C2H96_20965	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C2H96_20970	COG0492	ferredoxin-NADP+ reductase activity
C2H96_20975	COG2339	peptidase activity
C2H96_20980	COG3409	Peptidoglycan-binding domain 1 protein
C2H96_20980	COG3773	Cell wall hydrolase
C2H96_20985	COG2959	enzyme of heme biosynthesis
C2H96_20990	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
C2H96_21000	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C2H96_21005	COG0539	negative regulation of cytoplasmic translation
C2H96_21010	COG1304	FMN binding
C2H96_21035	COG1160	GTP binding
C2H96_21040	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
C2H96_21055	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
C2H96_21060	COG0776	regulation of translation
C2H96_21065	COG0302	gtp cyclohydrolase
C2H96_21075	COG0142	geranyltranstransferase activity
C2H96_21080	COG2226	methyltransferase
C2H96_21085	COG0142	geranyltranstransferase activity
C2H96_21090	COG0105	UTP biosynthetic process
C2H96_21095	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
C2H96_21100	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
C2H96_21105	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C2H96_21110	COG4401	Chorismate mutase type I
C2H96_21115	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C2H96_21120	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
C2H96_21130	COG0135	phosphoribosylanthranilate isomerase activity
C2H96_21135	COG0133	tryptophan synthase activity
C2H96_21140	COG0159	tryptophan synthase activity
C2H96_21150	COG0287	Prephenate dehydrogenase
C2H96_21155	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
C2H96_21160	COG0457	Tetratricopeptide repeat
C2H96_21165	COG5582	Belongs to the UPF0302 family
C2H96_21175	COG0723	plastoquinol--plastocyanin reductase activity
C2H96_21180	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2H96_21185	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C2H96_21185	COG2010	Cytochrome c
C2H96_21190	COG4347	Protein of unknown function (DUF1405)
C2H96_21200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
C2H96_21205	COG1694	Mazg nucleotide pyrophosphohydrolase
C2H96_21210	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
C2H96_21215	COG1803	Methylglyoxal synthase
C2H96_21220	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C2H96_21225	COG0438	transferase activity, transferring glycosyl groups
C2H96_21230	COG0617	tRNA 3'-terminal CCA addition
C2H96_21235	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
C2H96_21235	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
C2H96_21240	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
C2H96_21245	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
C2H96_21250	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
C2H96_21255	COG1199	ATP-dependent helicase activity
C2H96_21255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C2H96_21265	COG5353	protein conserved in bacteria
C2H96_21270	COG0436	Aminotransferase
C2H96_21275	COG0017	Asparaginyl-tRNA synthetase
C2H96_21280	COG3935	DnaD domain protein
C2H96_21285	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C2H96_21295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C2H96_21295	COG4499	WXG100 protein secretion system (Wss), protein YukC
C2H96_21300	COG3331	DNA recombination
C2H96_21335	COG0071	Belongs to the small heat shock protein (HSP20) family
C2H96_21340	COG2190	(PTS) system
C2H96_21345	COG1111	helicase
C2H96_21345	COG1205	dead DEAH box helicase
C2H96_21350	COG3359	exonuclease
C2H96_21360	COG4474	Belongs to the UPF0398 family
C2H96_21375	COG0116	Belongs to the methyltransferase superfamily
C2H96_21390	COG1199	ATP-dependent helicase activity
C2H96_21395	COG1028	Short-chain dehydrogenase reductase Sdr
C2H96_21400	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
C2H96_21405	COG1609	Transcriptional regulator
C2H96_21410	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C2H96_21415	COG0800	Aldolase