locus-tag	class	description
U712_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
U712_00010	COG0592	DNA-directed DNA polymerase activity
U712_00015	COG2501	S4 domain
U712_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
U712_00030	COG0187	DNA topoisomerase II activity
U712_00040	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
U712_00050	COG0517	IMP dehydrogenase activity
U712_00050	COG0516	GMP reductase activity
U712_00055	COG1686	Belongs to the peptidase S11 family
U712_00060	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
U712_00065	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
U712_00070	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
U712_00075	COG1428	Deoxynucleoside kinase
U712_00085	COG1388	LysM domain
U712_00085	COG3858	chitin binding
U712_00090	COG1335	isochorismatase
U712_00095	COG0590	tRNA wobble adenosine to inosine editing
U712_00100	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
U712_00105	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
U712_00110	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
U712_00130	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
U712_00135	COG3853	Toxic anion resistance protein (TelA)
U712_00140	COG1982	Orn Lys Arg decarboxylase major
U712_00145	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
U712_00150	COG3870	Protein conserved in bacteria
U712_00155	COG1728	Protein conserved in bacteria
U712_00160	COG0470	DNA polymerase III
U712_00165	COG1774	PSP1 C-terminal conserved region
U712_00170	COG4467	Involved in initiation control of chromosome replication
U712_00175	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
U712_00180	COG2827	Endonuclease containing a URI domain
U712_00185	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
U712_00190	COG2002	toxin-antitoxin pair type II binding
U712_00195	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U712_00195	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U712_00200	COG0084	hydrolase, TatD family'
U712_00205	COG3583	domain protein
U712_00205	COG3584	3D domain protein
U712_00210	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
U712_00215	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
U712_00225	COG4466	Protein conserved in bacteria
U712_00235	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
U712_00240	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
U712_00245	COG0251	oxidation-reduction process
U712_00250	COG2088	sporulation resulting in formation of a cellular spore
U712_00260	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
U712_00265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
U712_00270	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
U712_00275	COG0193	aminoacyl-tRNA hydrolase activity
U712_00285	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
U712_00290	COG2002	toxin-antitoxin pair type II binding
U712_00295	COG2244	polysaccharide biosynthetic process
U712_00300	COG3956	TIGRFAM MazG family protein
U712_00305	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
U712_00320	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
U712_00325	COG1098	S1 RNA binding domain
U712_00330	COG2208	phosphoserine phosphatase activity
U712_00335	COG2304	oxidoreductase activity
U712_00340	COG0515	serine threonine protein kinase
U712_00345	COG0037	tRNA processing
U712_00355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
U712_00360	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
U712_00365	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
U712_00370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
U712_00375	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
U712_00380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
U712_00385	COG0512	Glutamine amidotransferase of anthranilate synthase
U712_00390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
U712_00395	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
U712_00400	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
U712_00405	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
U712_00410	COG1396	sequence-specific DNA binding
U712_00415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
U712_00420	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
U712_00425	COG4463	regulation of RNA biosynthetic process
U712_00430	COG3880	PFAM UvrB UvrC protein
U712_00435	COG3869	Catalyzes the specific phosphorylation of arginine residues in
U712_00440	COG0542	response to heat
U712_00445	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
U712_00450	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
U712_00455	COG4956	integral membrane protein (PIN domain superfamily)
U712_00460	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
U712_00465	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
U712_00470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
U712_00485	COG1045	serine acetyltransferase
U712_00490	COG0215	cysteine-tRNA ligase activity
U712_00495	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
U712_00500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
U712_00505	COG3688	RNA-binding protein containing a PIN domain
U712_00510	COG1595	DNA-templated transcription, initiation
U712_00515	COG0267	Belongs to the bacterial ribosomal protein bL33 family
U712_00520	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
U712_00525	COG0250	Participates in transcription elongation, termination and antitermination
U712_00530	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
U712_00535	COG0081	regulation of translation
U712_00540	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
U712_00545	COG0222	ribosome binding
U712_00550	COG2813	Specifically methylates the guanine in position
U712_00555	COG0085	RNA polymerase activity
U712_00560	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
U712_00565	COG1358	cellular component organization or biogenesis
U712_00570	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
U712_00575	COG0049	tRNA binding
U712_00580	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
U712_00585	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
U712_00590	COG0596	Alpha beta hydrolase
U712_00595	COG0051	transcription antitermination factor activity, RNA binding
U712_00600	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
U712_00605	COG0088	Forms part of the polypeptide exit tunnel
U712_00610	COG0089	rRNA binding
U712_00615	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
U712_00620	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
U712_00625	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
U712_00630	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
U712_00635	COG0255	Belongs to the universal ribosomal protein uL29 family
U712_00640	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
U712_00645	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
U712_00655	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
U712_00665	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
U712_00670	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
U712_00675	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
U712_00685	COG1841	ribosomal large subunit assembly
U712_00690	COG0200	Binds to the 23S rRNA
U712_00695	COG0201	protein transport
U712_00700	COG0563	adenylate kinase activity
U712_00705	COG0024	Methionine aminopeptidase
U712_00710	COG2163	COG2163 Ribosomal protein L14E L6E L27E
U712_00715	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
U712_00720	COG0257	Belongs to the bacterial ribosomal protein bL36 family
U712_00725	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
U712_00730	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
U712_00735	COG0202	RNA polymerase activity
U712_00740	COG0203	ribosomal protein L17
U712_00745	COG1122	ATPase activity
U712_00750	COG1122	ATPase activity
U712_00755	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
U712_00760	COG0101	tRNA pseudouridine synthase activity
U712_00765	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
U712_00770	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
U712_00775	COG2226	methyltransferase
U712_00785	COG0860	N-Acetylmuramoyl-L-alanine amidase
U712_00790	COG0489	protein tyrosine kinase activity
U712_00800	COG2194	sulfuric ester hydrolase activity
U712_00805	COG0726	polysaccharide deacetylase
U712_00815	COG0659	secondary active sulfate transmembrane transporter activity
U712_00820	COG0385	Bile acid
U712_00825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U712_00830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U712_00835	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
U712_00840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
U712_00840	COG2207	Transcriptional regulator
U712_00845	COG3876	Protein conserved in bacteria
U712_00850	COG1472	Belongs to the glycosyl hydrolase 3 family
U712_00855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
U712_00860	COG1263	PTS System
U712_00860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U712_00865	COG1737	Transcriptional regulator
U712_00870	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
U712_00875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
U712_00880	COG1683	Conserved Protein
U712_00885	COG1595	DNA-templated transcription, initiation
U712_00890	COG5662	AntiSigma factor
U712_00895	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
U712_00900	COG4856	YbbR-like protein
U712_00905	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
U712_00915	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
U712_00920	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
U712_00925	COG2169	Transcriptional regulator
U712_00930	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
U712_00935	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
U712_00940	COG3002	Belongs to the UPF0753 family
U712_00945	COG0288	reversible hydration of carbon dioxide
U712_00955	COG5609	conserved protein (DUF2294)
U712_00965	COG0640	Transcriptional regulator
U712_00975	COG2814	Major facilitator Superfamily
U712_00980	COG0535	radical SAM domain protein
U712_00985	COG1266	CAAX protease self-immunity
U712_00990	COG1131	(ABC) transporter
U712_01000	COG1413	lyase activity
U712_01005	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U712_01010	COG0596	Alpha beta hydrolase
U712_01015	COG0745	RESPONSE REGULATOR receiver
U712_01020	COG0642	Histidine kinase
U712_01030	COG0515	serine threonine protein kinase
U712_01045	COG1113	amino acid transport
U712_01060	COG2602	Beta-lactamase
U712_01065	COG2124	cytochrome p450
U712_01075	COG0531	amino acid
U712_01080	COG0584	glycerophosphoryl diester phosphodiesterase
U712_01085	COG2271	Major facilitator Superfamily
U712_01095	COG0456	acetyltransferase
U712_01095	COG1846	Transcriptional regulator
U712_01100	COG2271	Major facilitator Superfamily
U712_01120	COG3409	Peptidoglycan-binding domain 1 protein
U712_01125	COG0697	spore germination
U712_01130	COG1917	Cupin 2, conserved barrel domain protein
U712_01130	COG2207	Transcriptional regulator
U712_01135	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
U712_01140	COG3591	Belongs to the peptidase S1B family
U712_01150	COG0596	Alpha beta hydrolase
U712_01155	COG1183	phosphatidylcholine synthase activity
U712_01160	COG0586	Pfam SNARE associated Golgi protein
U712_01165	COG0688	phosphatidylethanolamine metabolic process
U712_01175	COG2312	Erythromycin esterase
U712_01180	COG2207	Transcriptional regulator
U712_01190	COG1301	dicarboxylic acid transport
U712_01195	COG2190	(PTS) system
U712_01195	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U712_01195	COG1263	PTS System
U712_01200	COG0363	glucosamine-6-phosphate deaminase activity
U712_01215	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
U712_01220	COG0833	amino acid
U712_01225	COG2040	homocysteine
U712_01235	COG1115	amino acid carrier protein
U712_01240	COG2066	Belongs to the glutaminase family
U712_01245	COG4191	Histidine kinase
U712_01250	COG0784	Response regulator, receiver
U712_01255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
U712_01260	COG1012	belongs to the aldehyde dehydrogenase family
U712_01265	COG2271	Major facilitator Superfamily
U712_01270	COG4948	Mandelate Racemase Muconate Lactonizing
U712_01275	COG2186	Transcriptional regulator
U712_01280	COG2721	sulfolactate sulfo-lyase activity
U712_01290	COG3173	Aminoglycoside phosphotransferase
U712_01300	COG0697	spore germination
U712_01305	COG0745	RESPONSE REGULATOR receiver
U712_01310	COG2205	protein histidine kinase activity
U712_01315	COG1131	(ABC) transporter
U712_01335	COG3773	Cell wall hydrolase
U712_01340	COG2304	oxidoreductase activity
U712_01350	COG3540	Alkaline phosphatase
U712_01355	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
U712_01360	COG0805	protein transport
U712_01365	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
U712_01370	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
U712_01375	COG0477	Major facilitator Superfamily
U712_01380	COG1309	transcriptional regulator
U712_01390	COG0252	asparaginase activity
U712_01395	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
U712_01400	COG1714	RDD family
U712_01405	COG3012	SEC-C Motif Domain Protein
U712_01405	COG1405	negative regulation of cell septum assembly
U712_01410	COG3290	protein histidine kinase activity
U712_01415	COG3279	Response regulator of the LytR AlgR family
U712_01420	COG4555	ABC transporter
U712_01425	COG1668	transmembrane transport
U712_01430	COG0667	Aldo Keto reductase
U712_01440	COG1595	DNA-templated transcription, initiation
U712_01445	COG1595	DNA-templated transcription, initiation
U712_01450	COG1876	peptidase activity
U712_01455	COG0457	Tetratricopeptide repeat
U712_01460	COG1028	Short-chain dehydrogenase reductase Sdr
U712_01465	COG0366	Alpha amylase catalytic
U712_01470	COG0803	Belongs to the bacterial solute-binding protein 9 family
U712_01475	COG1121	(ABC) transporter
U712_01480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
U712_01485	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
U712_01490	COG2310	stress, protein
U712_01495	COG2310	stress, protein
U712_01500	COG2310	stress, protein
U712_01505	COG0861	Integral membrane protein TerC family
U712_01515	COG3853	Toxic anion resistance protein (TelA)
U712_01520	COG0477	Major facilitator Superfamily
U712_01525	COG2814	Major facilitator Superfamily
U712_01530	COG0640	Transcriptional regulator
U712_01535	COG4175	Glycine betaine
U712_01535	COG0517	IMP dehydrogenase activity
U712_01540	COG4176	ABC-type proline glycine betaine transport system permease component
U712_01545	COG2113	Glycine betaine
U712_01550	COG1473	amidohydrolase
U712_01555	COG1288	antiporter activity
U712_01565	COG0366	Alpha amylase catalytic
U712_01575	COG0039	L-malate dehydrogenase activity
U712_01580	COG1620	l-lactate permease
U712_01585	COG2814	Major facilitator Superfamily
U712_01590	COG1846	Transcriptional regulator
U712_01595	COG1280	lysine exporter protein (LysE YggA)
U712_01600	COG3403	YqcI/YcgG family
U712_01605	COG1113	amino acid transport
U712_01610	COG3665	Urea carboxylase-associated protein
U712_01615	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
U712_01620	COG1660	Displays ATPase and GTPase activities
U712_01625	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
U712_01630	COG2226	methyltransferase
U712_01635	COG0583	DNA-binding transcription factor activity
U712_01640	COG3458	cephalosporin-C deacetylase activity
U712_01645	COG3541	Predicted nucleotidyltransferase
U712_01650	COG0506	proline dehydrogenase activity
U712_01655	COG1012	belongs to the aldehyde dehydrogenase family
U712_01660	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
U712_01665	COG2508	Transcriptional regulator
U712_01670	COG3689	TIGRFAM TIGR03943 family protein
U712_01675	COG0701	Predicted permease
U712_01680	COG2267	carboxylic ester hydrolase activity
U712_01685	COG0492	ferredoxin-NADP+ reductase activity
U712_01690	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
U712_01690	COG1587	Uroporphyrinogen-III synthase
U712_01695	COG2146	nitrite reductase [NAD(P)H] activity
U712_01700	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
U712_01705	COG0243	molybdopterin cofactor binding
U712_01710	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
U712_01715	COG2223	nitrite transmembrane transporter activity
U712_01720	COG1469	GTP cyclohydrolase I activity
U712_01725	COG1376	ErfK ybiS ycfS ynhG family protein
U712_01735	COG0523	cobalamin synthesis protein
U712_01740	COG0765	amino acid transport
U712_01745	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U712_01755	COG1714	RDD family
U712_01765	COG2723	6-phospho-beta-galactosidase activity
U712_01775	COG3209	COG3209 Rhs family protein
U712_01780	COG0840	transmembrane signaling receptor activity
U712_01780	COG3290	protein histidine kinase activity
U712_01785	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
U712_01790	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
U712_01795	COG1733	regulation of RNA biosynthetic process
U712_01805	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U712_01810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U712_01815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U712_01820	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
U712_01825	COG2814	Major facilitator Superfamily
U712_01835	COG0697	spore germination
U712_01840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
U712_01850	COG2364	Membrane
U712_01860	COG1126	abc transporter atp-binding protein
U712_01865	COG0765	amino acid transport
U712_01870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U712_01875	COG0583	DNA-binding transcription factor activity
U712_01880	COG0163	prenyltransferase activity
U712_01885	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
U712_01895	COG0596	Alpha beta hydrolase
U712_01900	COG3104	oligopeptide transport
U712_01905	COG5434	Belongs to the glycosyl hydrolase 28 family
U712_01915	COG0697	spore germination
U712_01925	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
U712_01930	COG1136	(ABC) transporter
U712_01935	COG0577	efflux transmembrane transporter activity
U712_01940	COG0745	RESPONSE REGULATOR receiver
U712_01945	COG5002	protein histidine kinase activity
U712_01945	COG3850	Histidine kinase
U712_01950	COG0457	Tetratricopeptide repeat
U712_01970	COG0527	aspartate kinase activity
U712_01975	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U712_01980	COG4605	iron ion homeostasis
U712_01985	COG4604	ABC transporter, ATP-binding protein
U712_01990	COG4607	ABC-type enterochelin transport system periplasmic component
U712_01995	COG2814	Major facilitator Superfamily
U712_02000	COG1309	transcriptional regulator
U712_02005	COG0778	Nitroreductase
U712_02010	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
U712_02015	COG0640	Transcriptional regulator
U712_02020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
U712_02025	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
U712_02030	COG1012	belongs to the aldehyde dehydrogenase family
U712_02035	COG4975	Glucose uptake
U712_02040	COG1028	Short-chain dehydrogenase reductase Sdr
U712_02045	COG4549	nuclear export factor GLE1
U712_02050	COG2372	response to copper ion
U712_02050	COG1276	copper resistance
U712_02055	COG1349	DNA-binding transcription factor activity
U712_02070	COG0246	Mannitol dehydrogenase
U712_02075	COG0473	3-isopropylmalate dehydrogenase activity
U712_02085	COG0681	Belongs to the peptidase S26 family
U712_02090	COG0412	Dienelactone hydrolase
U712_02095	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
U712_02100	COG0561	phosphatase activity
U712_02105	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
U712_02110	COG1914	H( )-stimulated, divalent metal cation uptake system
U712_02115	COG4336	lyase activity
U712_02125	COG1414	Transcriptional regulator
U712_02130	COG2755	lipolytic protein G-D-S-L family
U712_02140	COG2329	Antibiotic biosynthesis monooxygenase
U712_02145	COG0768	penicillin binding
U712_02150	COG4989	oxidoreductase activity
U712_02155	COG3711	transcriptional antiterminator
U712_02165	COG0318	PFAM AMP-dependent synthetase and ligase
U712_02170	COG2226	methyltransferase
U712_02175	COG1028	Short-chain dehydrogenase reductase Sdr
U712_02180	COG1917	Cupin 2, conserved barrel domain protein
U712_02185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
U712_02190	COG3871	stress protein (general stress protein 26)
U712_02200	COG2814	Major facilitator Superfamily
U712_02205	COG1914	H( )-stimulated, divalent metal cation uptake system
U712_02210	COG2261	transglycosylase associated protein
U712_02220	COG4876	unkown
U712_02225	COG2217	Heavy metal translocating P-type atpase
U712_02230	COG3729	General stress protein
U712_02235	COG0662	Cupin 2, conserved barrel domain protein
U712_02240	COG2329	Antibiotic biosynthesis monooxygenase
U712_02245	COG3546	catalase activity
U712_02250	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
U712_02255	COG3290	protein histidine kinase activity
U712_02260	COG4565	transcriptional regulatory protein
U712_02265	COG1301	dicarboxylic acid transport
U712_02270	COG0628	permease
U712_02280	COG1131	(ABC) transporter
U712_02285	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
U712_02295	COG1960	acyl-CoA dehydrogenase activity
U712_02310	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
U712_02315	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U712_02320	COG1181	Belongs to the D-alanine--D-alanine ligase family
U712_02325	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
U712_02330	COG0513	Belongs to the DEAD box helicase family
U712_02335	COG3402	PFAM membrane-flanked domain
U712_02340	COG3428	Bacterial PH domain
U712_02345	COG0705	Rhomboid family
U712_02350	COG0736	holo-[acyl-carrier-protein] synthase activity
U712_02355	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
U712_02360	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
U712_02365	COG0864	Transcriptional regulator
U712_02370	COG2337	Toxic component of a toxin-antitoxin (TA) module
U712_02375	COG1366	Belongs to the anti-sigma-factor antagonist family
U712_02380	COG1366	Belongs to the anti-sigma-factor antagonist family
U712_02385	COG2172	sigma factor antagonist activity
U712_02390	COG2208	phosphoserine phosphatase activity
U712_02395	COG1366	Belongs to the anti-sigma-factor antagonist family
U712_02400	COG2172	sigma factor antagonist activity
U712_02405	COG1191	sigma factor activity
U712_02410	COG2208	phosphoserine phosphatase activity
U712_02430	COG1673	EVE domain
U712_02435	COG1846	Transcriptional regulator
U712_02440	COG2183	response to ionizing radiation
U712_02450	COG3091	SprT-like family
U712_02455	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
U712_02460	COG1522	sequence-specific DNA binding
U712_02465	COG1522	sequence-specific DNA binding
U712_02470	COG1335	isochorismatase
U712_02475	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
U712_02480	COG2814	Major facilitator Superfamily
U712_02500	COG0693	protein deglycase activity
U712_02505	COG1278	Cold shock
U712_02510	COG1329	Transcriptional regulator
U712_02520	COG0697	spore germination
U712_02525	COG1917	Cupin 2, conserved barrel domain protein
U712_02525	COG2207	Transcriptional regulator
U712_02530	COG0697	spore germination
U712_02535	COG2207	Transcriptional regulator
U712_02535	COG3708	Transcriptional regulator
U712_02540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
U712_02545	COG0477	Major facilitator Superfamily
U712_02555	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
U712_02570	COG0697	spore germination
U712_02575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
U712_02580	COG2030	dehydratase
U712_02585	COG3545	Serine hydrolase
U712_02590	COG1733	regulation of RNA biosynthetic process
U712_02595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
U712_02600	COG1733	regulation of RNA biosynthetic process
U712_02605	COG2249	NAD(P)H dehydrogenase (quinone) activity
U712_02610	COG2814	Major facilitator Superfamily
U712_02615	COG1309	transcriptional regulator
U712_02625	COG0640	Transcriptional regulator
U712_02630	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
U712_02640	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
U712_02645	COG0697	spore germination
U712_02650	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
U712_02655	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
U712_02660	COG0640	Transcriptional regulator
U712_02665	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
U712_02680	COG4585	Histidine kinase
U712_02685	COG2197	response regulator
U712_02690	COG2409	Drug exporters of the RND superfamily
U712_02700	COG0596	Alpha beta hydrolase
U712_02710	COG1811	Na channel or pump
U712_02715	COG0789	Transcriptional regulator
U712_02715	COG4978	Transcriptional regulator
U712_02720	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
U712_02725	COG0778	Nitroreductase
U712_02730	COG0346	lactoylglutathione lyase activity
U712_02735	COG2259	Doxx family
U712_02740	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U712_02765	COG2323	membrane
U712_02770	COG2323	membrane
U712_02775	COG0071	Belongs to the small heat shock protein (HSP20) family
U712_02790	COG1309	transcriptional regulator
U712_02800	COG0456	acetyltransferase
U712_02810	COG1113	amino acid transport
U712_02815	COG2318	DinB family
U712_02820	COG1846	Transcriptional regulator
U712_02825	COG1033	growth of symbiont in host cell
U712_02825	COG2409	Drug exporters of the RND superfamily
U712_02830	COG0778	Nitroreductase
U712_02835	COG1846	Transcriptional regulator
U712_02840	COG2814	Major facilitator Superfamily
U712_02845	COG0730	response to heat
U712_02850	COG1802	Transcriptional regulator
U712_02855	COG3858	chitin binding
U712_02855	COG1388	LysM domain
U712_02860	COG1819	glycosyl
U712_02870	COG1785	Belongs to the alkaline phosphatase family
U712_02875	COG5646	InterPro IPR014922
U712_02885	COG0454	-acetyltransferase
U712_02890	COG1078	dGTPase activity
U712_02900	COG1388	LysM domain
U712_02905	COG2814	Major facilitator Superfamily
U712_02910	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
U712_02915	COG1447	Phosphotransferase system cellobiose-specific component IIA
U712_02920	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
U712_02925	COG2723	6-phospho-beta-galactosidase activity
U712_02930	COG2188	Transcriptional regulator
U712_02935	COG1940	carbohydrate kinase activity
U712_02940	COG1482	cell wall glycoprotein biosynthetic process
U712_02945	COG4124	Belongs to the glycosyl hydrolase 26 family
U712_02955	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
U712_02960	COG0802	atpase or kinase
U712_02965	COG1214	PFAM Peptidase M22, glycoprotease
U712_02970	COG0456	acetyltransferase
U712_02975	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
U712_02980	COG0488	(ABC) transporter
U712_02985	COG0315	cyclic pyranopterin monophosphate synthase activity
U712_02990	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
U712_02995	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
U712_03000	COG0805	protein transport
U712_03010	COG1266	CAAX protease self-immunity
U712_03015	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
U712_03020	COG0459	protein refolding
U712_03040	COG0270	DNA (cytosine-5-)-methyltransferase activity
U712_03045	COG0270	DNA (cytosine-5-)-methyltransferase activity
U712_03055	COG1401	restriction endodeoxyribonuclease activity
U712_03075	COG1073	alpha beta
U712_03080	COG0457	Tetratricopeptide repeat
U712_03085	COG1063	alcohol dehydrogenase
U712_03090	COG2211	Major facilitator Superfamily
U712_03095	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U712_03100	COG1842	Phage shock protein A
U712_03105	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
U712_03110	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
U712_03115	COG4260	virion core protein, lumpy skin disease virus
U712_03130	COG2814	Major facilitator Superfamily
U712_03135	COG1063	alcohol dehydrogenase
U712_03140	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
U712_03145	COG0823	Involved in the tonB-independent uptake of proteins
U712_03160	COG2267	carboxylic ester hydrolase activity
U712_03170	COG2132	Multicopper oxidase
U712_03175	COG1113	amino acid transport
U712_03185	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
U712_03190	COG0714	Associated with various cellular activities
U712_03195	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
U712_03200	COG1305	Transglutaminase-like
U712_03210	COG0519	Catalyzes the synthesis of GMP from XMP
U712_03210	COG0518	GMP synthase (glutamine-hydrolyzing) activity
U712_03215	COG2252	PERMEase
U712_03220	COG3064	Membrane
U712_03230	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
U712_03240	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
U712_03245	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
U712_03250	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
U712_03255	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
U712_03260	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
U712_03265	COG0047	phosphoribosylformylglycinamidine synthase activity
U712_03270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
U712_03275	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
U712_03280	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
U712_03285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
U712_03290	COG0138	bifunctional purine biosynthesis protein purh
U712_03295	COG0151	Belongs to the GarS family
U712_03300	COG1522	sequence-specific DNA binding
U712_03305	COG0531	amino acid
U712_03315	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
U712_03320	COG1470	cell adhesion involved in biofilm formation
U712_03325	COG4496	protein, YerC YecD
U712_03330	COG0069	glutamate synthase activity
U712_03340	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
U712_03345	COG0210	DNA helicase
U712_03350	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
U712_03355	COG4851	CamS sex pheromone cAM373 precursor
U712_03360	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
U712_03365	COG1285	pathogenesis
U712_03370	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
U712_03375	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
U712_03380	COG0154	amidase activity
U712_03385	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
U712_03390	COG1309	transcriptional regulator
U712_03395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
U712_03400	COG1597	lipid kinase activity
U712_03405	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
U712_03410	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
U712_03415	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
U712_03420	COG1002	Type II restriction enzyme, methylase subunits
U712_03425	COG1061	Type III restriction enzyme res subunit
U712_03430	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
U712_03445	COG5444	nuclease activity
U712_03450	COG3391	amine dehydrogenase activity
U712_03455	COG0457	Tetratricopeptide repeat
U712_03460	COG0217	transcriptional regulatory protein
U712_03470	COG3631	Ketosteroid isomerase-related protein
U712_03475	COG0702	epimerase
U712_03490	COG3546	catalase activity
U712_03495	COG0454	-acetyltransferase
U712_03505	COG5578	integral membrane protein
U712_03510	COG2972	Histidine kinase
U712_03515	COG4753	response regulator
U712_03515	COG2207	Transcriptional regulator
U712_03520	COG1653	transport
U712_03525	COG1175	transmembrane transport
U712_03530	COG0395	ABC-type sugar transport system, permease component
U712_03535	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
U712_03540	COG2207	Transcriptional regulator
U712_03545	COG2755	lipolytic protein G-D-S-L family
U712_03555	COG5578	integral membrane protein
U712_03560	COG3401	FG-GAP repeat protein
U712_03565	COG3401	FG-GAP repeat protein
U712_03570	COG2755	lipolytic protein G-D-S-L family
U712_03575	COG1874	Beta-galactosidase
U712_03585	COG1653	transport
U712_03590	COG4209	transmembrane transport
U712_03595	COG0395	ABC-type sugar transport system, permease component
U712_03600	COG1486	melibiose metabolic process
U712_03605	COG2323	membrane
U712_03610	COG2329	Antibiotic biosynthesis monooxygenase
U712_03615	COG0346	lactoylglutathione lyase activity
U712_03630	COG5583	Uncharacterized small protein (DUF2292)
U712_03635	COG0670	Belongs to the BI1 family
U712_03640	COG0697	spore germination
U712_03645	COG1846	Transcriptional regulator
U712_03650	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
U712_03660	COG2124	cytochrome p450
U712_03660	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
U712_03670	COG1368	sulfuric ester hydrolase activity
U712_03680	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
U712_03685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
U712_03690	COG1442	glycosyl transferase family 8
U712_03695	COG1216	Glycosyl transferase, family 2
U712_03700	COG1442	glycosyl transferase family 8
U712_03705	COG2223	nitrite transmembrane transporter activity
U712_03710	COG1011	Hydrolase
U712_03715	COG0531	amino acid
U712_03720	COG1012	belongs to the aldehyde dehydrogenase family
U712_03725	COG0840	transmembrane signaling receptor activity
U712_03730	COG0488	(ABC) transporter
U712_03740	COG0789	Transcriptional regulator
U712_03745	COG2814	Major facilitator Superfamily
U712_03760	COG0488	(ABC) transporter
U712_03765	COG0513	Belongs to the DEAD box helicase family
U712_03770	COG0456	acetyltransferase
U712_03775	COG2130	NADP-dependent
U712_03785	COG2211	Major facilitator Superfamily
U712_03790	COG1262	PFAM Formylglycine-generating sulfatase enzyme
U712_03805	COG1120	ATPase activity
U712_03810	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U712_03815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U712_03820	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
U712_03835	COG3866	Pectate lyase
U712_03840	COG0471	metal ion transport
U712_03845	COG3290	protein histidine kinase activity
U712_03850	COG4565	transcriptional regulatory protein
U712_03855	COG3181	Tripartite tricarboxylate transporter family receptor
U712_03865	COG2851	Citrate transporter
U712_03870	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U712_03875	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
U712_03880	COG1254	Belongs to the acylphosphatase family
U712_03885	COG2258	MOSC domain
U712_03905	COG0024	Methionine aminopeptidase
U712_03910	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U712_03910	COG1263	PTS System
U712_03915	COG1368	sulfuric ester hydrolase activity
U712_03925	COG1115	amino acid carrier protein
U712_03930	COG0531	amino acid
U712_03945	COG0697	spore germination
U712_03950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U712_03950	COG1263	PTS System
U712_03955	COG0366	Alpha amylase catalytic
U712_03960	COG2188	Transcriptional regulator
U712_03965	COG0778	Nitroreductase
U712_03970	COG0737	Belongs to the 5'-nucleotidase family
U712_03975	COG0693	protein deglycase activity
U712_03980	COG2814	Major facilitator Superfamily
U712_03985	COG4840	Belongs to the UPF0435 family
U712_03995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
U712_04000	COG4980	gas vesicle protein
U712_04005	COG1295	ribonuclease BN
U712_04010	COG0477	Major facilitator Superfamily
U712_04020	COG0387	Pfam Sodium calcium exchanger
U712_04030	COG0668	transmembrane transport
U712_04035	COG0535	radical SAM domain protein
U712_04045	COG0726	polysaccharide deacetylase
U712_04050	COG2084	Dehydrogenase
U712_04055	COG0598	Magnesium transport protein CorA
U712_04060	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
U712_04065	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
U712_04070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
U712_04075	COG4637	Psort location Cytoplasmic, score
U712_04085	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
U712_04090	COG0022	dehydrogenase e1 component
U712_04095	COG0508	dehydrogenase complex catalyzes the overall conversion of
U712_04100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
U712_04105	COG3284	Transcriptional regulator
U712_04115	COG1742	UPF0060 membrane protein
U712_04140	COG4842	Belongs to the WXG100 family
U712_04145	COG1486	melibiose metabolic process
U712_04150	COG1737	Transcriptional regulator
U712_04155	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U712_04155	COG1263	PTS System
U712_04160	COG1132	(ABC) transporter
U712_04165	COG1132	(ABC) transporter
U712_04170	COG2259	Doxx family
U712_04175	COG2514	catechol 2,3-dioxygenase activity
U712_04180	COG1917	Cupin 2, conserved barrel domain protein
U712_04180	COG4977	sequence-specific DNA binding
U712_04185	COG2814	Major facilitator Superfamily
U712_04190	COG1082	Xylose isomerase domain protein TIM barrel
U712_04195	COG0673	inositol 2-dehydrogenase activity
U712_04205	COG4585	Histidine kinase
U712_04210	COG2197	response regulator
U712_04220	COG1131	(ABC) transporter
U712_04225	COG0842	Transport permease protein
U712_04225	COG1511	domain protein
U712_04230	COG0842	Transport permease protein
U712_04235	COG1695	Transcriptional regulator
U712_04245	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
U712_04250	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
U712_04255	COG1309	transcriptional regulator
U712_04260	COG2814	Major facilitator Superfamily
U712_04265	COG2318	DinB family
U712_04270	COG2814	Major facilitator Superfamily
U712_04275	COG1846	Transcriptional regulator
U712_04280	COG0392	lysyltransferase activity
U712_04280	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
U712_04285	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
U712_04295	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U712_04300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U712_04305	COG0384	phenazine biosynthesis protein PhzF
U712_04310	COG0778	Nitroreductase
U712_04325	COG1090	epimerase
U712_04330	COG2137	regulation of response to DNA damage stimulus
U712_04340	COG2814	Major facilitator Superfamily
U712_04355	COG3103	Sh3 type 3 domain protein
U712_04360	COG5658	integral membrane protein
U712_04365	COG0596	Alpha beta hydrolase
U712_04375	COG0463	Glycosyl transferase, family 2
U712_04380	COG4485	Bacterial membrane protein, YfhO
U712_04385	COG1988	membrane-bound metal-dependent
U712_04390	COG1194	a g-specific adenine glycosylase
U712_04400	COG1028	Short-chain dehydrogenase reductase Sdr
U712_04415	COG3557	Belongs to the UPF0374 family
U712_04420	COG1132	(ABC) transporter
U712_04425	COG4129	membrane
U712_04430	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
U712_04435	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
U712_04440	COG0735	belongs to the Fur family
U712_04455	COG4326	sporulation control protein
U712_04465	COG5577	PFAM Coat F domain
U712_04470	COG3340	Belongs to the peptidase S51 family
U712_04475	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
U712_04480	COG0277	FAD linked oxidase domain protein
U712_04490	COG0753	catalase activity
U712_04495	COG1116	anion transmembrane transporter activity
U712_04500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
U712_04505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
U712_04510	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
U712_04520	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
U712_04530	COG1476	TRANSCRIPTIONal
U712_04535	COG3382	B3 4 domain protein
U712_04540	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
U712_04550	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
U712_04555	COG0789	Transcriptional regulator
U712_04560	COG1664	Polymer-forming cytoskeletal
U712_04565	COG1664	Polymer-forming cytoskeletal
U712_04575	COG2766	serine protein kinase
U712_04580	COG2718	Belongs to the UPF0229 family
U712_04585	COG1846	Transcriptional regulator
U712_04590	COG1566	PFAM secretion protein HlyD family protein
U712_04595	COG2814	Major facilitator Superfamily
U712_04600	COG0655	NAD(P)H dehydrogenase (quinone) activity
U712_04620	COG1725	Transcriptional regulator
U712_04625	COG1131	(ABC) transporter
U712_04630	COG1131	(ABC) transporter
U712_04635	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
U712_04640	COG1278	Cold shock
U712_04645	COG1464	Belongs to the NlpA lipoprotein family
U712_04650	COG3706	GGDEF domain
U712_04655	COG1823	symporter activity
U712_04675	COG0737	Belongs to the 5'-nucleotidase family
U712_04675	COG4085	toxin activity
U712_04675	COG1525	nuclease
U712_04680	COG3764	Sortase (surface protein transpeptidase)
U712_04685	COG0564	pseudouridine synthase activity
U712_04695	COG0517	IMP dehydrogenase activity
U712_04700	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
U712_04705	COG3153	acetyltransferase
U712_04705	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
U712_04715	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
U712_04720	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
U712_04725	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
U712_04730	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
U712_04735	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
U712_04740	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
U712_04745	COG2203	Gaf domain
U712_04745	COG4585	Histidine kinase
U712_04750	COG2197	response regulator
U712_04755	COG0431	NADPH-dependent FMN reductase
U712_04770	COG0791	NLP P60 protein
U712_04770	COG1388	LysM domain
U712_04775	COG1959	2 iron, 2 sulfur cluster binding
U712_04780	COG0668	transmembrane transport
U712_04785	COG2719	SpoVR family
U712_04790	COG1785	Belongs to the alkaline phosphatase family
U712_04795	COG1388	LysM domain
U712_04795	COG0791	NLP P60 protein
U712_04800	COG0583	DNA-binding transcription factor activity
U712_04805	COG0372	Belongs to the citrate synthase family
U712_04810	COG1028	Short-chain dehydrogenase reductase Sdr
U712_04815	COG0531	amino acid
U712_04820	COG0733	neurotransmitter:sodium symporter activity
U712_04825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
U712_04830	COG0456	acetyltransferase
U712_04845	COG1595	DNA-templated transcription, initiation
U712_04850	COG0667	Aldo Keto reductase
U712_04855	COG0204	Acyl-transferase
U712_04860	COG1253	flavin adenine dinucleotide binding
U712_04865	COG0789	Transcriptional regulator
U712_04870	COG0436	Aminotransferase
U712_04880	COG1253	flavin adenine dinucleotide binding
U712_04885	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
U712_04890	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
U712_04895	COG0584	glycerophosphoryl diester phosphodiesterase
U712_04905	COG0668	transmembrane transport
U712_04910	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
U712_04915	COG0726	polysaccharide deacetylase
U712_04920	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
U712_04925	COG1757	Na H antiporter
U712_04930	COG0589	response to stress
U712_04940	COG1132	(ABC) transporter
U712_04945	COG1132	(ABC) transporter
U712_04950	COG0702	epimerase
U712_04970	COG0189	ligase activity
U712_04975	COG0189	ligase activity
U712_04980	COG4399	Belongs to the UPF0754 family
U712_04985	COG3679	Belongs to the UPF0342 family
U712_04990	COG4335	DNA alkylation repair
U712_04995	COG0561	phosphatase activity
U712_05000	COG0635	Involved in the biosynthesis of porphyrin-containing compound
U712_05005	COG0475	glutathione-regulated potassium exporter activity
U712_05010	COG0490	domain, Protein
U712_05020	COG1024	Enoyl-CoA hydratase
U712_05030	COG4152	abc transporter atp-binding protein
U712_05035	COG1668	transmembrane transport
U712_05040	COG0420	3'-5' exonuclease activity
U712_05045	COG4717	serine-type aminopeptidase activity
U712_05050	COG3481	metal-dependent phosphohydrolase, HD sub domain
U712_05060	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
U712_05085	COG1846	Transcriptional regulator
U712_05090	COG4980	gas vesicle protein
U712_05105	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
U712_05110	COG0537	adenosine 5'-monophosphoramidase activity
U712_05115	COG1131	(ABC) transporter
U712_05120	COG4473	ABC transporter
U712_05130	COG1473	amidohydrolase
U712_05135	COG3069	C4-dicarboxylate transmembrane transporter activity
U712_05145	COG2329	Antibiotic biosynthesis monooxygenase
U712_05150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
U712_05155	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
U712_05175	COG1309	transcriptional regulator
U712_05180	COG1511	domain protein
U712_05185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
U712_05190	COG4377	Putative membrane peptidase family (DUF2324)
U712_05200	COG1363	Peptidase, m42
U712_05205	COG4405	Protein conserved in bacteria
U712_05210	COG1301	dicarboxylic acid transport
U712_05220	COG1234	tRNA 3'-trailer cleavage
U712_05225	COG0095	Lipoate-protein ligase
U712_05230	COG0702	epimerase
U712_05235	COG0318	PFAM AMP-dependent synthetase and ligase
U712_05245	COG0501	Belongs to the peptidase M48B family
U712_05250	COG1404	Belongs to the peptidase S8 family
U712_05260	COG0456	acetyltransferase
U712_05265	COG0604	alcohol dehydrogenase
U712_05275	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
U712_05280	COG0406	alpha-ribazole phosphatase activity
U712_05285	COG0183	Belongs to the thiolase family
U712_05290	COG0318	PFAM AMP-dependent synthetase and ligase
U712_05295	COG1268	BioY protein
U712_05300	COG0840	transmembrane signaling receptor activity
U712_05305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
U712_05305	COG0723	plastoquinol--plastocyanin reductase activity
U712_05310	COG1028	Short-chain dehydrogenase reductase Sdr
U712_05320	COG4903	ComK protein
U712_05325	COG1028	Short-chain dehydrogenase reductase Sdr
U712_05340	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
U712_05355	COG0398	Pfam SNARE associated Golgi protein
U712_05360	COG0681	Belongs to the peptidase S26 family
U712_05365	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
U712_05370	COG1846	Transcriptional regulator
U712_05375	COG0738	Major facilitator superfamily
U712_05380	COG0673	inositol 2-dehydrogenase activity
U712_05385	COG0561	phosphatase activity
U712_05390	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
U712_05395	COG1609	Transcriptional regulator
U712_05400	COG3180	Ammonia monooxygenase
U712_05405	COG2814	Major facilitator Superfamily
U712_05405	COG0477	Major facilitator Superfamily
U712_05410	COG4533	DNA binding
U712_05425	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
U712_05430	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
U712_05435	COG1074	ATP-dependent DNA helicase activity
U712_05440	COG0420	3'-5' exonuclease activity
U712_05445	COG0419	ATPase involved in DNA repair
U712_05450	COG1403	HNH endonuclease
U712_05495	COG5337	Spore coat protein CotH
U712_05500	COG0179	Fumarylacetoacetate (FAA) hydrolase
U712_05510	COG1404	Belongs to the peptidase S8 family
U712_05520	COG0367	asparagine synthase
U712_05525	COG2318	DinB family
U712_05530	COG1562	ergosterol biosynthetic process
U712_05535	COG0534	Mate efflux family protein
U712_05540	COG2207	Transcriptional regulator
U712_05540	COG1917	Cupin 2, conserved barrel domain protein
U712_05545	COG1609	Transcriptional regulator
U712_05555	COG0673	inositol 2-dehydrogenase activity
U712_05560	COG2318	DinB family
U712_05565	COG1279	arginine transmembrane transporter activity
U712_05570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
U712_05575	COG1357	PFAM Pentapeptide repeats (8 copies)
U712_05580	COG2267	carboxylic ester hydrolase activity
U712_05585	COG0529	Catalyzes the synthesis of activated sulfate
U712_05590	COG2046	Belongs to the sulfate adenylyltransferase family
U712_05595	COG0175	sulfate reduction
U712_05600	COG2045	Belongs to the ComB family
U712_05605	COG1809	phosphosulfolactate synthase activity
U712_05610	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
U712_05615	COG4948	Mandelate Racemase Muconate Lactonizing
U712_05620	COG2814	Major facilitator Superfamily
U712_05625	COG0454	-acetyltransferase
U712_05630	COG2153	protein acetylation
U712_05635	COG0646	methionine synthase
U712_05635	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
U712_05640	COG1666	GTP binding
U712_05645	COG2996	Protein conserved in bacteria
U712_05670	COG1695	Transcriptional regulator
U712_05685	COG3227	Zinc metalloprotease (Elastase)
U712_05690	COG1307	EDD domain protein, DegV family
U712_05695	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
U712_05715	COG0561	phosphatase activity
U712_05720	COG1073	alpha beta
U712_05725	COG2151	metal-sulfur cluster biosynthetic enzyme
U712_05735	COG0277	FAD linked oxidase domain protein
U712_05740	COG2271	Major facilitator Superfamily
U712_05745	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
U712_05760	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
U712_05765	COG0505	Belongs to the CarA family
U712_05770	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
U712_05775	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
U712_05790	COG2267	carboxylic ester hydrolase activity
U712_05805	COG1744	ABC transporter substrate-binding protein PnrA-like
U712_05820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
U712_05825	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
U712_05830	COG5504	Zn-dependent protease
U712_05835	COG0444	Belongs to the ABC transporter superfamily
U712_05840	COG4608	Belongs to the ABC transporter superfamily
U712_05850	COG0601	transmembrane transport
U712_05855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
U712_05865	COG0180	Tryptophanyl-tRNA synthetase
U712_05870	COG4166	transmembrane transport
U712_05875	COG0601	transmembrane transport
U712_05880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
U712_05885	COG0444	Belongs to the ABC transporter superfamily
U712_05890	COG4608	Belongs to the ABC transporter superfamily
U712_05900	COG2814	Major facilitator Superfamily
U712_05905	COG0456	acetyltransferase
U712_05910	COG1393	Belongs to the ArsC family
U712_05915	COG0861	Integral membrane protein TerC family
U712_05920	COG4862	establishment of competence for transformation
U712_05930	COG4469	Competence protein
U712_05935	COG1164	Oligoendopeptidase f
U712_05950	COG2346	COG2346, Truncated hemoglobins
U712_05955	COG0741	lytic transglycosylase activity
U712_05960	COG4116	CYTH
U712_05970	COG2357	RelA SpoT domain protein
U712_05975	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
U712_05980	COG0564	pseudouridine synthase activity
U712_05985	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
U712_05990	COG0475	glutathione-regulated potassium exporter activity
U712_05990	COG0569	domain protein
U712_05995	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
U712_06000	COG0352	thiamine-phosphate diphosphorylase activity
U712_06005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
U712_06010	COG2104	thiamine diphosphate biosynthetic process
U712_06015	COG2022	thiamine diphosphate biosynthetic process
U712_06020	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
U712_06025	COG0351	phosphomethylpyrimidine kinase
U712_06030	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
U712_06100	COG0210	DNA helicase
U712_06110	COG2153	protein acetylation
U712_06115	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
U712_06120	COG2382	esterase
U712_06130	COG0626	cystathionine gamma-synthase activity
U712_06135	COG0626	cystathionine gamma-synthase activity
U712_06140	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
U712_06145	COG5505	Protein of unknown function (DUF819)
U712_06175	COG3677	Transposase
U712_06190	COG5484	DNA packaging
U712_06195	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
U712_06200	COG1028	Short-chain dehydrogenase reductase Sdr
U712_06210	COG3711	transcriptional antiterminator
U712_06210	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
U712_06215	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U712_06215	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
U712_06215	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U712_06220	COG1482	cell wall glycoprotein biosynthetic process
U712_06230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
U712_06235	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
U712_06255	COG0109	protoheme IX farnesyltransferase activity
U712_06265	COG0726	polysaccharide deacetylase
U712_06285	COG5504	Zn-dependent protease
U712_06290	COG2205	protein histidine kinase activity
U712_06300	COG3383	formate dehydrogenase (NAD+) activity
U712_06305	COG2427	Protein of unknown function (DUF1641)
U712_06315	COG1051	belongs to the nudix hydrolase family
U712_06325	COG2124	cytochrome p450
U712_06330	COG1819	glycosyl
U712_06340	COG1587	Uroporphyrinogen-III synthase
U712_06345	COG0390	transport system, permease component
U712_06350	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
U712_06355	COG0697	spore germination
U712_06365	COG4297	protein containing double-stranded beta helix domain
U712_06380	COG1252	NADH dehydrogenase
U712_06390	COG1904	glucuronate isomerase
U712_06395	COG2211	Major facilitator Superfamily
U712_06400	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
U712_06405	COG1063	alcohol dehydrogenase
U712_06410	COG1312	Catalyzes the dehydration of D-mannonate
U712_06415	COG1028	Short-chain dehydrogenase reductase Sdr
U712_06420	COG2271	Major facilitator Superfamily
U712_06425	COG1609	Transcriptional regulator
U712_06430	COG0246	Mannitol dehydrogenase
U712_06435	COG2721	sulfolactate sulfo-lyase activity
U712_06440	COG0730	response to heat
U712_06445	COG2318	DinB family
U712_06450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
U712_06455	COG0457	Tetratricopeptide repeat
U712_06465	COG2350	Protein conserved in bacteria
U712_06470	COG5632	N-Acetylmuramoyl-L-alanine amidase
U712_06470	COG1388	LysM domain
U712_06470	COG3409	Peptidoglycan-binding domain 1 protein
U712_06480	COG4195	phage-related replication protein
U712_06485	COG3546	catalase activity
U712_06490	COG2856	Zn peptidase
U712_06495	COG1396	sequence-specific DNA binding
U712_06505	COG1522	sequence-specific DNA binding
U712_06515	COG1484	DNA-dependent DNA replication
U712_06535	COG1595	DNA-templated transcription, initiation
U712_06540	COG3728	DNA packaging
U712_06540	COG5484	DNA packaging
U712_06545	COG1783	phage Terminase large subunit
U712_06550	COG5518	Phage portal protein
U712_06555	COG0338	D12 class N6 adenine-specific DNA methyltransferase
U712_06560	COG4653	Phage capsid family
U712_06605	COG3953	SLT domain
U712_06605	COG5412	phage tail tape measure protein
U712_06610	COG1652	LysM domain
U712_06615	COG4193	domain, Protein
U712_06625	COG3628	GPW Gp25 family protein
U712_06630	COG3299	homolog of phage Mu protein gp47
U712_06635	COG3778	Protein conserved in bacteria
U712_06675	COG3409	Peptidoglycan-binding domain 1 protein
U712_06675	COG5632	N-Acetylmuramoyl-L-alanine amidase
U712_06695	COG0306	phosphate transporter
U712_06700	COG1392	Phosphate transport regulator
U712_06705	COG0531	amino acid
U712_06710	COG0346	lactoylglutathione lyase activity
U712_06715	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
U712_06720	COG0463	Glycosyl transferase, family 2
U712_06730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
U712_06735	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
U712_06740	COG2362	D-Aminopeptidase
U712_06745	COG0601	transmembrane transport
U712_06750	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
U712_06755	COG0444	Belongs to the ABC transporter superfamily
U712_06760	COG4166	transmembrane transport
U712_06770	COG1619	proteins homologs of microcin C7 resistance protein MccF
U712_06775	COG4948	Mandelate Racemase Muconate Lactonizing
U712_06780	COG0791	NLP P60 protein
U712_06785	COG4608	Belongs to the ABC transporter superfamily
U712_06790	COG2706	6-phosphogluconolactonase activity
U712_06795	COG1834	amidinotransferase
U712_06800	COG1607	acyl-coa hydrolase
U712_06805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
U712_06805	COG1017	nitric oxide dioxygenase activity
U712_06815	COG2323	membrane
U712_06820	COG2318	DinB family
U712_06825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
U712_06830	COG2076	Multidrug Resistance protein
U712_06835	COG2076	Multidrug Resistance protein
U712_06840	COG0788	formyltetrahydrofolate deformylase activity
U712_06845	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
U712_06850	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
U712_06855	COG1764	response to oxidative stress
U712_06860	COG1846	Transcriptional regulator
U712_06865	COG1764	response to oxidative stress
U712_06875	COG0590	tRNA wobble adenosine to inosine editing
U712_06880	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
U712_06890	COG1404	Belongs to the peptidase S8 family
U712_06900	COG1366	Belongs to the anti-sigma-factor antagonist family
U712_06905	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
U712_06910	COG1122	ATPase activity
U712_06915	COG4721	ABC-type cobalt transport system, permease component
U712_06925	COG0745	RESPONSE REGULATOR receiver
U712_06930	COG3850	Histidine kinase
U712_06930	COG5002	protein histidine kinase activity
U712_06935	COG3212	peptidase
U712_06940	COG3212	peptidase
U712_06950	COG2239	Acts as a magnesium transporter
U712_06955	COG0789	Transcriptional regulator
U712_06970	COG1846	Transcriptional regulator
U712_06975	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
U712_06980	COG0726	polysaccharide deacetylase
U712_06985	COG1408	metallophosphoesterase
U712_06995	COG0463	Glycosyl transferase, family 2
U712_07000	COG1793	dna ligase
U712_07000	COG3285	dna ligase
U712_07005	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
U712_07010	COG5001	Diguanylate cyclase
U712_07010	COG3300	MHYT domain
U712_07015	COG0586	Pfam SNARE associated Golgi protein
U712_07025	COG0861	Integral membrane protein TerC family
U712_07030	COG1191	sigma factor activity
U712_07050	COG0501	Belongs to the peptidase M48B family
U712_07055	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
U712_07070	COG3594	Acyltransferase
U712_07075	COG5002	protein histidine kinase activity
U712_07080	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
U712_07090	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
U712_07095	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
U712_07100	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
U712_07105	COG0436	Aminotransferase
U712_07110	COG1850	ribulose-bisphosphate carboxylase activity
U712_07120	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
U712_07125	COG3339	Conserved Protein
U712_07140	COG3852	Histidine kinase
U712_07145	COG1846	Transcriptional regulator
U712_07150	COG1360	Flagellar Motor Protein
U712_07155	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
U712_07160	COG0542	response to heat
U712_07165	COG3949	Membrane
U712_07170	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
U712_07175	COG0720	synthase
U712_07180	COG0602	queuosine metabolic process
U712_07185	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
U712_07195	COG1733	regulation of RNA biosynthetic process
U712_07200	COG1028	Short-chain dehydrogenase reductase Sdr
U712_07205	COG1388	LysM domain
U712_07205	COG4641	Protein conserved in bacteria
U712_07210	COG1388	LysM domain
U712_07215	COG3858	chitin binding
U712_07220	COG3858	chitin binding
U712_07240	COG4873	Protein conserved in bacteria
U712_07255	COG3773	Cell wall hydrolase
U712_07260	COG2244	polysaccharide biosynthetic process
U712_07265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U712_07270	COG2217	Heavy metal translocating P-type atpase
U712_07280	COG0006	proline dipeptidase activity
U712_07290	COG1609	Transcriptional regulator
U712_07295	COG3711	transcriptional antiterminator
U712_07300	COG1263	PTS System
U712_07300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U712_07300	COG2190	(PTS) system
U712_07305	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
U712_07310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
U712_07320	COG1533	DNA photolyase activity
U712_07325	COG0456	acetyltransferase
U712_07330	COG0840	transmembrane signaling receptor activity
U712_07335	COG2084	Dehydrogenase
U712_07340	COG2340	Cysteine-rich secretory protein family
U712_07345	COG0768	penicillin binding
U712_07350	COG4191	Histidine kinase
U712_07355	COG0436	Aminotransferase
U712_07365	COG0784	Response regulator, receiver
U712_07365	COG0835	chemotaxis
U712_07375	COG2814	Major facilitator Superfamily
U712_07380	COG1376	ErfK ybiS ycfS ynhG family protein
U712_07385	COG1408	metallophosphoesterase
U712_07390	COG1028	Short-chain dehydrogenase reductase Sdr
U712_07395	COG3409	Peptidoglycan-binding domain 1 protein
U712_07405	COG2200	EAL domain
U712_07415	COG4703	Protein of unknown function (DUF1797)
U712_07420	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
U712_07430	COG0517	IMP dehydrogenase activity
U712_07435	COG0583	DNA-binding transcription factor activity
U712_07440	COG0716	FMN binding
U712_07450	COG0716	FMN binding
U712_07455	COG2171	N-acyltransferase activity
U712_07460	COG1473	amidohydrolase
U712_07470	COG0668	transmembrane transport
U712_07475	COG0450	alkyl hydroperoxide reductase
U712_07480	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U712_07495	COG0746	molybdenum cofactor guanylyltransferase activity
U712_07500	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
U712_07505	COG0303	'Molybdopterin
U712_07510	COG1763	Mo-molybdopterin cofactor biosynthetic process
U712_07515	COG0314	molybdopterin synthase activity
U712_07520	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
U712_07525	COG1132	(ABC) transporter
U712_07530	COG1132	(ABC) transporter
U712_07540	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U712_07545	COG1136	(ABC) transporter
U712_07550	COG0577	efflux transmembrane transporter activity
U712_07555	COG1349	DNA-binding transcription factor activity
U712_07560	COG1105	Belongs to the carbohydrate kinase PfkB family
U712_07565	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U712_07565	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
U712_07565	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
U712_07570	COG0681	Belongs to the peptidase S26 family
U712_07580	COG0488	(ABC) transporter
U712_07585	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
U712_07590	COG2309	aminopeptidase activity
U712_07600	COG1077	Cell shape determining protein MreB Mrl
U712_07605	COG2002	toxin-antitoxin pair type II binding
U712_07610	COG3852	Histidine kinase
U712_07615	COG2105	PFAM AIG2 family protein
U712_07615	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
U712_07620	COG0569	domain protein
U712_07625	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
U712_07630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
U712_07645	COG0561	phosphatase activity
U712_07650	COG0242	peptide deformylase activity
U712_07660	COG0497	DNA recombination
U712_07665	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
U712_07670	COG0022	dehydrogenase e1 component
U712_07675	COG0508	dehydrogenase complex catalyzes the overall conversion of
U712_07680	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
U712_07685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U712_07695	COG1982	Orn Lys Arg decarboxylase major
U712_07700	COG4476	Belongs to the UPF0223 family
U712_07705	COG4493	Belongs to the UPF0637 family
U712_07720	COG0483	inositol monophosphate 1-phosphatase activity
U712_07730	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
U712_07755	COG1595	DNA-templated transcription, initiation
U712_07785	COG4896	Protein conserved in bacteria
U712_07795	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
U712_07800	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
U712_07805	COG2066	Belongs to the glutaminase family
U712_07810	COG4838	Belongs to the UPF0358 family
U712_07820	COG0772	Belongs to the SEDS family
U712_07825	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
U712_07830	COG1612	heme a metabolic process
U712_07835	COG0109	protoheme IX farnesyltransferase activity
U712_07845	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
U712_07845	COG2010	Cytochrome c
U712_07850	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
U712_07855	COG1845	cytochrome c oxidase, subunit III
U712_07860	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
U712_07865	COG3336	cytochrome c oxidase
U712_07875	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
U712_07880	COG2340	Cysteine-rich secretory protein family
U712_07895	COG3679	Belongs to the UPF0342 family
U712_07900	COG4471	UPF0298 protein
U712_07910	COG0742	ribosomal rna small subunit methyltransferase
U712_07915	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
U712_07920	COG3314	Sporulation integral membrane protein YlbJ
U712_07925	COG1752	Esterase of the alpha-beta hydrolase superfamily
U712_07930	COG3480	Lon protease (S16) C-terminal proteolytic domain
U712_07935	COG1323	Belongs to the UPF0348 family
U712_07945	COG1399	metal-binding, possibly nucleic acid-binding protein
U712_07960	COG0454	-acetyltransferase
U712_07965	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
U712_07970	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
U712_07975	COG2001	Belongs to the MraZ family
U712_07980	COG0275	rRNA processing
U712_07985	COG4839	cell division protein FtsL
U712_07995	COG0768	penicillin binding
U712_08000	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
U712_08005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
U712_08010	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
U712_08015	COG0772	Belongs to the SEDS family
U712_08020	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
U712_08025	COG0812	UDP-N-acetylmuramate dehydrogenase activity
U712_08030	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
U712_08035	COG3879	Bacterial protein of unknown function (DUF881)
U712_08040	COG3879	Bacterial protein of unknown function (DUF881)
U712_08045	COG3856	small basic protein
U712_08050	COG0849	cell division
U712_08055	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
U712_08060	COG4412	M6 family metalloprotease domain protein
U712_08060	COG1404	Belongs to the peptidase S8 family
U712_08070	COG1191	sigma factor activity
U712_08075	COG1191	sigma factor activity
U712_08080	COG1119	ATPase activity
U712_08085	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
U712_08090	COG1873	PFAM PRC-barrel domain
U712_08100	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
U712_08105	COG1799	cell septum assembly
U712_08110	COG0762	integral membrane protein
U712_08115	COG2302	S4 RNA-binding domain
U712_08120	COG3599	regulation of cell shape
U712_08130	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
U712_08135	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
U712_08140	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
U712_08145	COG0564	pseudouridine synthase activity
U712_08150	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
U712_08155	COG2233	PERMEase
U712_08160	COG0540	Belongs to the ATCase OTCase family
U712_08165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
U712_08170	COG0505	Belongs to the CarA family
U712_08175	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
U712_08180	COG0543	2 iron, 2 sulfur cluster binding
U712_08185	COG0167	dihydroorotate dehydrogenase activity
U712_08190	COG0284	orotidine-5'-phosphate decarboxylase activity
U712_08195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
U712_08200	COG0175	sulfate reduction
U712_08205	COG0306	phosphate transporter
U712_08210	COG2046	Belongs to the sulfate adenylyltransferase family
U712_08215	COG0529	Catalyzes the synthesis of activated sulfate
U712_08220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
U712_08225	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
U712_08230	COG1648	precorrin-2 dehydrogenase activity
U712_08240	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
U712_08245	COG1561	YicC-like family, N-terminal region
U712_08250	COG2052	Domain of unknown function (DUF370)
U712_08255	COG0194	GDP metabolic process
U712_08260	COG1758	RNA polymerase activity
U712_08265	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
U712_08270	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
U712_08275	COG0242	peptide deformylase activity
U712_08280	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
U712_08285	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
U712_08285	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
U712_08290	COG0820	rRNA (adenine-C2-)-methyltransferase activity
U712_08295	COG0631	protein serine/threonine phosphatase activity
U712_08300	COG0515	serine threonine protein kinase
U712_08300	COG2815	serine threonine protein kinase
U712_08305	COG1162	GTPase activity
U712_08310	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
U712_08315	COG1564	THIamine pyrophosphokinase
U712_08320	COG0227	Belongs to the bacterial ribosomal protein bL28 family
U712_08325	COG1302	Protein conserved in bacteria
U712_08330	COG1461	Dihydroxyacetone kinase
U712_08335	COG1760	l-serine dehydratase
U712_08340	COG1760	l-serine dehydratase
U712_08345	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
U712_08350	COG1349	DNA-binding transcription factor activity
U712_08350	COG2050	protein possibly involved in aromatic compounds catabolism
U712_08355	COG0416	fatty acid biosynthetic process
U712_08360	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
U712_08365	COG1028	Short-chain dehydrogenase reductase Sdr
U712_08370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
U712_08375	COG0571	ribonuclease III activity
U712_08380	COG1196	nuclear chromosome segregation
U712_08385	COG0552	protein localization to endoplasmic reticulum
U712_08395	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
U712_08400	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
U712_08405	COG0228	four-way junction DNA binding
U712_08410	COG1837	Belongs to the UPF0109 family
U712_08420	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
U712_08425	COG0336	Belongs to the RNA methyltransferase TrmD family
U712_08430	COG0335	large ribosomal subunit rRNA binding
U712_08435	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
U712_08440	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
U712_08450	COG2257	FlhB HrpN YscU SpaS Family
U712_08455	COG0045	succinate-CoA ligase (ADP-forming) activity
U712_08460	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
U712_08465	COG0758	DNA mediated transformation
U712_08470	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
U712_08475	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
U712_08480	COG4974	Belongs to the 'phage' integrase family
U712_08485	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
U712_08490	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
U712_08495	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
U712_08500	COG1815	bacterial-type flagellum-dependent cell motility
U712_08505	COG1558	bacterial-type flagellum-dependent cell motility
U712_08510	COG1677	Flagellar hook-basal body complex protein FliE
U712_08515	COG1766	The M ring may be actively involved in energy transduction
U712_08520	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
U712_08525	COG1317	bacterial-type flagellum organization
U712_08530	COG1157	protein secretion by the type III secretion system
U712_08535	COG2882	bacterial-type flagellum organization
U712_08540	COG3334	PFAM MgtE intracellular
U712_08545	COG3144	bacterial-type flagellum assembly
U712_08550	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
U712_08555	COG4786	Flagellar basal body rod
U712_08560	COG1582	Flagellar protein (FlbD)
U712_08565	COG1580	Controls the rotational direction of flagella during chemotaxis
U712_08570	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
U712_08575	COG1776	CheC inhibitor of MCP methylation
U712_08575	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
U712_08580	COG2201	protein-glutamate methylesterase activity
U712_08585	COG3190	flagellar
U712_08590	COG1338	Plays a role in the flagellum-specific transport system
U712_08595	COG1987	bacterial-type flagellum assembly
U712_08600	COG1684	flagellar biosynthetic protein fliR
U712_08605	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
U712_08610	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
U712_08615	COG1419	protein localization to endoplasmic reticulum
U712_08620	COG0455	bacterial-type flagellum organization
U712_08625	COG2201	protein-glutamate methylesterase activity
U712_08630	COG0643	Histidine kinase
U712_08630	COG2198	Histidine kinase
U712_08635	COG0835	chemotaxis
U712_08640	COG1776	CheC inhibitor of MCP methylation
U712_08645	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
U712_08650	COG1191	sigma factor activity
U712_08660	COG0052	Belongs to the universal ribosomal protein uS2 family
U712_08665	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
U712_08670	COG0528	UMP kinase activity
U712_08675	COG0233	cytoplasmic translational termination
U712_08680	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
U712_08685	COG4589	Belongs to the CDS family
U712_08690	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
U712_08695	COG0750	zinc metalloprotease
U712_08700	COG0442	prolyl-tRNA aminoacylation
U712_08705	COG2176	DNA-directed DNA polymerase activity
U712_08710	COG0779	Required for maturation of 30S ribosomal subunits
U712_08715	COG0195	Participates in both transcription termination and antitermination
U712_08720	COG2740	Nucleic-acid-binding protein implicated in transcription termination
U712_08725	COG1358	cellular component organization or biogenesis
U712_08730	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
U712_08735	COG1550	Protein conserved in bacteria
U712_08740	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
U712_08745	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
U712_08750	COG0196	riboflavin kinase activity
U712_08755	COG1185	polyribonucleotide nucleotidyltransferase activity
U712_08760	COG0726	polysaccharide deacetylase
U712_08765	COG0612	Peptidase, M16
U712_08770	COG1873	PFAM PRC-barrel domain
U712_08780	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
U712_08785	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
U712_08790	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
U712_08795	COG0527	aspartate kinase activity
U712_08800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
U712_08805	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
U712_08810	COG0740	serine-type endopeptidase activity
U712_08820	COG1674	ftsk spoiiie
U712_08820	COG4980	gas vesicle protein
U712_08825	COG2188	Transcriptional regulator
U712_08835	COG2814	Major facilitator Superfamily
U712_08840	COG0612	Peptidase, M16
U712_08845	COG0612	Peptidase, M16
U712_08850	COG0300	oxidoreductase activity
U712_08865	COG1426	Protein conserved in bacteria
U712_08870	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
U712_08875	COG1058	Belongs to the CinA family
U712_08875	COG1546	Belongs to the CinA family
U712_08880	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
U712_08885	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
U712_08890	COG1418	mRNA catabolic process
U712_08895	COG1692	metallophosphoesterase
U712_08900	COG2359	stage V sporulation protein S
U712_08905	COG1063	alcohol dehydrogenase
U712_08910	COG0156	8-amino-7-oxononanoate synthase activity
U712_08915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
U712_08920	COG4550	Control of competence regulator ComK, YlbF/YmcA
U712_08930	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
U712_08935	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
U712_08950	COG3226	Transcriptional regulator
U712_08955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U712_08960	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
U712_08970	COG3321	synthase
U712_08975	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
U712_08975	COG2070	2-Nitropropane dioxygenase
U712_08980	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
U712_08985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
U712_08990	COG3425	synthase
U712_08995	COG1024	Enoyl-CoA hydratase
U712_09000	COG1024	Enoyl-CoA hydratase
U712_09005	COG0318	PFAM AMP-dependent synthetase and ligase
U712_09005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U712_09005	COG1028	Short-chain dehydrogenase reductase Sdr
U712_09005	COG3321	synthase
U712_09005	COG0300	oxidoreductase activity
U712_09010	COG0300	oxidoreductase activity
U712_09010	COG4221	oxidoreductase activity
U712_09010	COG3321	synthase
U712_09010	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
U712_09015	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
U712_09015	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
U712_09015	COG3321	synthase
U712_09015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U712_09015	COG1028	Short-chain dehydrogenase reductase Sdr
U712_09030	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
U712_09030	COG3321	synthase
U712_09030	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
U712_09030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
U712_09035	COG2124	cytochrome p450
U712_09045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U712_09055	COG1404	Belongs to the peptidase S8 family
U712_09065	COG4195	phage-related replication protein
U712_09070	COG1764	response to oxidative stress
U712_09075	COG2076	Multidrug Resistance protein
U712_09080	COG2076	Multidrug Resistance protein
U712_09095	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
U712_09100	COG1923	regulation of RNA biosynthetic process
U712_09115	COG1780	Probably involved in ribonucleotide reductase function
U712_09120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
U712_09125	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
U712_09130	COG4112	unkown
U712_09135	COG0860	N-Acetylmuramoyl-L-alanine amidase
U712_09145	COG0464	growth
U712_09150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
U712_09155	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
U712_09160	COG0789	Transcriptional regulator
U712_09165	COG0174	glutamine synthetase
U712_09180	COG4282	regulation of fungal-type cell wall biogenesis
U712_09190	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
U712_09195	COG2135	peptidase activity
U712_09220	COG0135	phosphoribosylanthranilate isomerase activity
U712_09225	COG2211	Major facilitator Superfamily
U712_09230	COG3507	Belongs to the glycosyl hydrolase 43 family
U712_09235	COG1940	carbohydrate kinase activity
U712_09240	COG2115	Belongs to the xylose isomerase family
U712_09245	COG1070	Carbohydrate kinase
U712_09255	COG1525	nuclease
U712_09260	COG2814	Major facilitator Superfamily
U712_09265	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
U712_09275	COG0756	dUTP diphosphatase activity
U712_09295	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
U712_09315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
U712_09330	COG3832	glyoxalase III activity
U712_09340	COG0697	spore germination
U712_09345	COG0531	amino acid
U712_09375	COG4195	phage-related replication protein
U712_09385	COG0346	lactoylglutathione lyase activity
U712_09395	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
U712_09400	COG1388	LysM domain
U712_09405	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
U712_09410	COG4224	UPF0291 protein
U712_09415	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
U712_09425	COG3763	UPF0154 protein
U712_09435	COG0785	Cytochrome C biogenesis protein
U712_09440	COG2201	protein-glutamate methylesterase activity
U712_09445	COG4846	Membrane protein involved in cytochrome C biogenesis
U712_09455	COG0071	Belongs to the small heat shock protein (HSP20) family
U712_09470	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
U712_09475	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U712_09495	COG0824	Thioesterase
U712_09505	COG4841	protein insertion into membrane
U712_09510	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
U712_09515	COG1832	CoA-binding protein
U712_09525	COG0187	DNA topoisomerase II activity
U712_09530	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
U712_09545	COG1115	amino acid carrier protein
U712_09550	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
U712_09560	COG5520	Belongs to the glycosyl hydrolase 30 family
U712_09565	COG3507	Belongs to the glycosyl hydrolase 43 family
U712_09570	COG2246	polysaccharide biosynthetic process
U712_09575	COG1210	Utp--glucose-1-phosphate uridylyltransferase
U712_09580	COG0586	Pfam SNARE associated Golgi protein
U712_09585	COG2404	hydrolase activity, acting on ester bonds
U712_09590	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
U712_09595	COG1024	Enoyl-CoA hydratase
U712_09600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
U712_09605	COG0511	ligase activity, forming carbon-carbon bonds
U712_09610	COG0439	Biotin carboxylase
U712_09615	COG0318	PFAM AMP-dependent synthetase and ligase
U712_09620	COG1960	acyl-CoA dehydrogenase activity
U712_09630	COG1649	PFAM Uncharacterised BCR, COG1649
U712_09640	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
U712_09640	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U712_09645	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U712_09650	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U712_09655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U712_09660	COG2027	D-alanyl-D-alanine carboxypeptidase
U712_09665	COG2017	converts alpha-aldose to the beta-anomer
U712_09670	COG0534	Mate efflux family protein
U712_09680	COG0582	viral genome integration into host DNA
U712_09685	COG0166	Belongs to the GPI family
U712_09690	COG0405	Gamma-glutamyltransferase
U712_09695	COG0583	DNA-binding transcription factor activity
U712_09700	COG0604	alcohol dehydrogenase
U712_09705	COG0493	'glutamate synthase
U712_09710	COG0067	glutamate synthase
U712_09710	COG0070	glutamate synthase
U712_09710	COG0069	glutamate synthase activity
U712_09715	COG0583	DNA-binding transcription factor activity
U712_09720	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
U712_09725	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
U712_09740	COG0300	oxidoreductase activity
U712_09745	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
U712_09755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
U712_09760	COG2814	Major facilitator Superfamily
U712_09765	COG1070	Carbohydrate kinase
U712_09770	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
U712_09775	COG0243	molybdopterin cofactor binding
U712_09800	COG0840	transmembrane signaling receptor activity
U712_09800	COG5278	phosphoserine phosphatase activity
U712_09805	COG2368	4-hydroxyphenylacetate
U712_09810	COG4305	rare lipoprotein A
U712_09815	COG3619	membrane
U712_09820	COG3866	Pectate lyase
U712_09825	COG2135	peptidase activity
U712_09835	COG2140	Oxalate decarboxylase
U712_09845	COG0456	acetyltransferase
U712_09860	COG2720	vancomycin resistance protein
U712_09870	COG3655	Transcriptional regulator
U712_09875	COG3739	integral membrane protein
U712_09880	COG0583	DNA-binding transcription factor activity
U712_09885	COG0697	spore germination
U712_09895	COG0693	protein deglycase activity
U712_09900	COG2367	Beta-lactamase
U712_09910	COG0574	Belongs to the PEP-utilizing enzyme family
U712_09910	COG3848	Pyruvate phosphate dikinase
U712_09915	COG0726	polysaccharide deacetylase
U712_09920	COG2314	TM2 domain
U712_09925	COG1396	sequence-specific DNA binding
U712_09940	COG2135	peptidase activity
U712_09970	COG0457	Tetratricopeptide repeat
U712_09975	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
U712_09980	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
U712_09995	COG5290	Psort location Cytoplasmic, score
U712_10010	COG5444	nuclease activity
U712_10015	COG4282	regulation of fungal-type cell wall biogenesis
U712_10020	COG1231	oxidoreductase activity
U712_10025	COG5434	Belongs to the glycosyl hydrolase 28 family
U712_10030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U712_10035	COG0662	Cupin 2, conserved barrel domain protein
U712_10035	COG2207	Transcriptional regulator
U712_10040	COG0456	acetyltransferase
U712_10045	COG1309	transcriptional regulator
U712_10050	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U712_10055	COG3708	Transcriptional regulator
U712_10060	COG2378	regulation of single-species biofilm formation
U712_10070	COG0640	Transcriptional regulator
U712_10075	COG0741	lytic transglycosylase activity
U712_10080	COG2322	membrane
U712_10095	COG1619	proteins homologs of microcin C7 resistance protein MccF
U712_10105	COG3239	Fatty acid desaturase
U712_10110	COG4585	Histidine kinase
U712_10115	COG2197	response regulator
U712_10120	COG1388	LysM domain
U712_10120	COG3584	3D domain protein
U712_10125	COG0514	ATP-dependent DNA helicase (RecQ)
U712_10135	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
U712_10140	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
U712_10155	COG0071	Belongs to the small heat shock protein (HSP20) family
U712_10180	COG1012	belongs to the aldehyde dehydrogenase family
U712_10185	COG1657	PFAM Prenyltransferase squalene oxidase
U712_10190	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
U712_10195	COG0733	neurotransmitter:sodium symporter activity
U712_10200	COG0385	Bile acid
U712_10205	COG0508	dehydrogenase complex catalyzes the overall conversion of
U712_10210	COG0567	Dehydrogenase, E1 component
U712_10215	COG4548	von Willebrand factor, type A
U712_10220	COG0714	Associated with various cellular activities
U712_10225	COG2032	superoxide dismutase activity
U712_10230	COG0791	NLP P60 protein
U712_10230	COG1388	LysM domain
U712_10235	COG1819	glycosyl
U712_10240	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
U712_10245	COG0534	Mate efflux family protein
U712_10250	COG1366	Belongs to the anti-sigma-factor antagonist family
U712_10255	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
U712_10260	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
U712_10270	COG2962	Rard protein
U712_10285	COG2610	gluconate transmembrane transporter activity
U712_10290	COG1942	4-Oxalocrotonate Tautomerase
U712_10300	COG1733	regulation of RNA biosynthetic process
U712_10305	COG0778	Nitroreductase
U712_10310	COG0400	carboxylic ester hydrolase activity
U712_10315	COG0346	lactoylglutathione lyase activity
U712_10325	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
U712_10330	COG3409	Peptidoglycan-binding domain 1 protein
U712_10330	COG0793	Belongs to the peptidase S41A family
U712_10335	COG2226	methyltransferase
U712_10345	COG1876	peptidase activity
U712_10350	COG0813	purine-nucleoside phosphorylase activity
U712_10370	COG0671	phosphoesterase, PA-phosphatase related
U712_10390	COG4479	Belongs to the UPF0346 family
U712_10400	COG1509	lysine 2,3-aminomutase activity
U712_10405	COG0456	acetyltransferase
U712_10410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
U712_10415	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
U712_10420	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
U712_10425	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
U712_10440	COG0456	acetyltransferase
U712_10445	COG0463	Glycosyl transferase, family 2
U712_10460	COG4641	Protein conserved in bacteria
U712_10465	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
U712_10470	COG1086	Polysaccharide biosynthesis protein
U712_10475	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
U712_10480	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
U712_10485	COG1846	Transcriptional regulator
U712_10490	COG0534	Mate efflux family protein
U712_10500	COG4698	Protein conserved in bacteria
U712_10505	COG2755	lipolytic protein G-D-S-L family
U712_10510	COG1999	signal sequence binding
U712_10520	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
U712_10525	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
U712_10530	COG1272	protein, Hemolysin III
U712_10535	COG0204	Acyl-transferase
U712_10540	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
U712_10545	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
U712_10550	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
U712_10560	COG2521	methyltransferase
U712_10560	COG2136	Putative SAM-dependent methyltransferase
U712_10570	COG0129	dihydroxy-acid dehydratase activity
U712_10575	COG1413	lyase activity
U712_10580	COG1418	mRNA catabolic process
U712_10585	COG0386	Belongs to the glutathione peroxidase family
U712_10590	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
U712_10595	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
U712_10600	COG1278	Cold shock
U712_10620	COG0328	RNA-DNA hybrid ribonuclease activity
U712_10625	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
U712_10630	COG0328	RNA-DNA hybrid ribonuclease activity
U712_10640	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
U712_10660	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
U712_10665	COG1755	Isoprenylcysteine carboxyl methyltransferase
U712_10670	COG3424	synthase
U712_10675	COG2233	PERMEase
U712_10680	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
U712_10685	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
U712_10695	COG0800	Aldolase
U712_10700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U712_10705	COG1609	Transcriptional regulator
U712_10710	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
U712_10715	COG1028	Short-chain dehydrogenase reductase Sdr
U712_10720	COG1199	ATP-dependent helicase activity
U712_10730	COG0116	Belongs to the methyltransferase superfamily
U712_10740	COG4474	Belongs to the UPF0398 family
U712_10750	COG3359	exonuclease
U712_10755	COG1205	dead DEAH box helicase
U712_10755	COG1111	helicase
U712_10760	COG2190	(PTS) system
U712_10765	COG0071	Belongs to the small heat shock protein (HSP20) family
U712_10800	COG3331	DNA recombination
U712_10805	COG4499	WXG100 protein secretion system (Wss), protein YukC
U712_10805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
U712_10815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
U712_10820	COG3935	DnaD domain protein
U712_10825	COG0017	Asparaginyl-tRNA synthetase
U712_10830	COG0436	Aminotransferase
U712_10835	COG5353	protein conserved in bacteria
U712_10845	COG1199	ATP-dependent helicase activity
U712_10845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
U712_10850	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
U712_10855	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
U712_10860	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
U712_10875	COG0617	tRNA 3'-terminal CCA addition
U712_10880	COG0438	transferase activity, transferring glycosyl groups
U712_10885	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
U712_10890	COG1803	Methylglyoxal synthase
U712_10895	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
U712_10900	COG1694	Mazg nucleotide pyrophosphohydrolase
U712_10905	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
U712_10915	COG4347	Protein of unknown function (DUF1405)
U712_10920	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
U712_10920	COG2010	Cytochrome c
U712_10925	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
U712_10930	COG0723	plastoquinol--plastocyanin reductase activity
U712_10940	COG5582	Belongs to the UPF0302 family
U712_10945	COG0457	Tetratricopeptide repeat
U712_10955	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
U712_10960	COG0287	Prephenate dehydrogenase
U712_10965	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
U712_10970	COG0159	tryptophan synthase activity
U712_10975	COG0133	tryptophan synthase activity
U712_10980	COG0135	phosphoribosylanthranilate isomerase activity
U712_10990	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
U712_10995	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
U712_11000	COG4401	Chorismate mutase type I
U712_11005	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
U712_11010	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
U712_11015	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
U712_11020	COG0105	UTP biosynthetic process
U712_11025	COG0142	geranyltranstransferase activity
U712_11030	COG2226	methyltransferase
U712_11035	COG0142	geranyltranstransferase activity
U712_11045	COG0302	gtp cyclohydrolase
U712_11050	COG0776	regulation of translation
U712_11055	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
U712_11070	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
U712_11075	COG1160	GTP binding
U712_11100	COG1304	FMN binding
U712_11105	COG0539	negative regulation of cytoplasmic translation
U712_11110	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
U712_11120	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
U712_11125	COG2959	enzyme of heme biosynthesis
U712_11130	COG3409	Peptidoglycan-binding domain 1 protein
U712_11130	COG3773	Cell wall hydrolase
U712_11135	COG2339	peptidase activity
U712_11140	COG0492	ferredoxin-NADP+ reductase activity
U712_11145	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
U712_11150	COG4862	establishment of competence for transformation
U712_11155	COG1408	metallophosphoesterase
U712_11165	COG1388	LysM domain
U712_11170	COG1266	CAAX protease self-immunity
U712_11175	COG0514	ATP-dependent DNA helicase (RecQ)
U712_11180	COG4955	Helix-turn-helix domain
U712_11185	COG1141	Ferredoxin
U712_11190	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
U712_11200	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
U712_11205	COG0710	3-dehydroquinate dehydratase activity
U712_11215	COG1595	DNA-templated transcription, initiation
U712_11220	COG5002	protein histidine kinase activity
U712_11225	COG0745	RESPONSE REGULATOR receiver
U712_11230	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
U712_11235	COG1333	cytochrome c biogenesis protein
U712_11250	COG1187	pseudouridine synthase activity
U712_11255	COG0700	Nucleoside recognition
U712_11260	COG2715	membrane protein required for spore maturation
U712_11265	COG1686	Belongs to the peptidase S11 family
U712_11275	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
U712_11280	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
U712_11285	COG1547	Domain of unknown function (DUF309)
U712_11290	COG0456	acetyltransferase
U712_11295	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
U712_11300	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
U712_11300	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
U712_11305	COG0307	riboflavin synthase, alpha
U712_11310	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
U712_11310	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
U712_11320	COG0681	Belongs to the peptidase S26 family
U712_11325	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
U712_11350	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
U712_11360	COG4086	secreted protein
U712_11365	COG0019	diaminopimelate decarboxylase activity
U712_11370	COG0697	spore germination
U712_11380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
U712_11400	COG1191	sigma factor activity
U712_11405	COG2172	sigma factor antagonist activity
U712_11410	COG1366	Belongs to the anti-sigma-factor antagonist family
U712_11415	COG1686	Belongs to the peptidase S11 family
U712_11420	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
U712_11425	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
U712_11430	COG4974	Belongs to the 'phage' integrase family
U712_11445	COG0735	belongs to the Fur family
U712_11450	COG1300	Membrane
U712_11460	COG0281	malic enzyme
U712_11465	COG1757	Na H antiporter
U712_11470	COG1027	Aspartate ammonia-lyase
U712_11475	COG0252	asparaginase activity
U712_11480	COG1396	sequence-specific DNA binding
U712_11485	COG1379	DNA repair
U712_11490	COG0494	nUDIX hydrolase
U712_11500	COG0667	Aldo Keto reductase
U712_11510	COG1073	alpha beta
U712_11520	COG4918	Iron-sulphur cluster biosynthesis
U712_11525	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
U712_11525	COG0456	acetyltransferase
U712_11530	COG2329	Antibiotic biosynthesis monooxygenase
U712_11535	COG0456	acetyltransferase
U712_11545	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
U712_11560	COG2211	Major facilitator Superfamily
U712_11570	COG0346	lactoylglutathione lyase activity
U712_11575	COG1072	(Pantothenic acid kinase))
U712_11580	COG3048	D-serine ammonia-lyase activity
U712_11585	COG0300	oxidoreductase activity
U712_11590	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U712_11595	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
U712_11600	COG4187	Peptidase family M20/M25/M40
U712_11605	COG1902	pentaerythritol trinitrate reductase activity
U712_11610	COG0596	Alpha beta hydrolase
U712_11615	COG1234	tRNA 3'-trailer cleavage
U712_11620	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
U712_11625	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
U712_11630	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
U712_11640	COG0706	membrane insertase activity
U712_11645	COG3361	conserved protein (COG2071)
U712_11650	COG2195	Cleaves the N-terminal amino acid of tripeptides
U712_11655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
U712_11660	COG0346	lactoylglutathione lyase activity
U712_11665	COG1376	ErfK ybiS ycfS ynhG family protein
U712_11670	COG4129	membrane
U712_11675	COG1126	abc transporter atp-binding protein
U712_11680	COG0765	amino acid transport
U712_11685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U712_11695	COG1597	lipid kinase activity
U712_11700	COG2814	Major facilitator Superfamily
U712_11705	COG4978	Transcriptional regulator
U712_11705	COG0789	Transcriptional regulator
U712_11710	COG0508	dehydrogenase complex catalyzes the overall conversion of
U712_11715	COG0022	dehydrogenase e1 component
U712_11720	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
U712_11725	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
U712_11730	COG3426	butyrate kinase activity
U712_11735	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
U712_11740	COG0280	phosphate acetyltransferase
U712_11745	COG3829	transcription factor binding
U712_11745	COG3290	protein histidine kinase activity
U712_11755	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
U712_11760	COG2079	MmgE PrpD family protein
U712_11765	COG0372	Belongs to the citrate synthase family
U712_11770	COG1960	acyl-CoA dehydrogenase activity
U712_11775	COG1250	3-hydroxyacyl-CoA dehydrogenase
U712_11780	COG0183	Belongs to the thiolase family
U712_11785	COG0584	glycerophosphoryl diester phosphodiesterase
U712_11790	COG0860	N-Acetylmuramoyl-L-alanine amidase
U712_11805	COG1902	pentaerythritol trinitrate reductase activity
U712_11815	COG0745	RESPONSE REGULATOR receiver
U712_11825	COG0750	zinc metalloprotease
U712_11830	COG0497	DNA recombination
U712_11835	COG1438	arginine binding
U712_11840	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
U712_11845	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
U712_11850	COG0142	geranyltranstransferase activity
U712_11855	COG1722	exodeoxyribonuclease VII activity
U712_11860	COG1570	exodeoxyribonuclease VII activity
U712_11865	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
U712_11870	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
U712_11875	COG1302	Protein conserved in bacteria
U712_11880	COG0439	Biotin carboxylase
U712_11885	COG0511	ligase activity, forming carbon-carbon bonds
U712_11925	COG3854	ATPases associated with a variety of cellular activities
U712_11935	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
U712_11940	COG0006	proline dipeptidase activity
U712_11945	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
U712_11955	COG3872	metal-dependent enzyme
U712_11965	COG1752	Esterase of the alpha-beta hydrolase superfamily
U712_11970	COG1321	iron dependent repressor
U712_11975	COG0095	Lipoate-protein ligase
U712_11980	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
U712_11985	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
U712_11990	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
U712_11995	COG0404	The glycine cleavage system catalyzes the degradation of glycine
U712_12000	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
U712_12015	COG1396	sequence-specific DNA binding
U712_12025	COG0681	Belongs to the peptidase S26 family
U712_12050	COG4940	Competence protein ComGF
U712_12060	COG4970	Tfp pilus assembly protein FimT
U712_12065	COG4537	Required for transformation and DNA binding
U712_12070	COG1459	type II secretion system
U712_12075	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
U712_12085	COG0598	Magnesium transport protein CorA
U712_12090	COG1253	flavin adenine dinucleotide binding
U712_12095	COG1366	Belongs to the anti-sigma-factor antagonist family
U712_12100	COG1393	Belongs to the ArsC family
U712_12110	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U712_12120	COG0011	TIGRFAM Protein of
U712_12130	COG2866	Carboxypeptidase
U712_12135	COG1368	sulfuric ester hydrolase activity
U712_12140	COG1940	carbohydrate kinase activity
U712_12145	COG4483	Protein conserved in bacteria
U712_12150	COG0705	Rhomboid family
U712_12150	COG0457	Tetratricopeptide repeat
U712_12160	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
U712_12170	COG0438	transferase activity, transferring glycosyl groups
U712_12190	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
U712_12195	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
U712_12200	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
U712_12205	COG0581	inorganic phosphate transmembrane transporter activity
U712_12210	COG0573	inorganic phosphate transmembrane transporter activity
U712_12215	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
U712_12225	COG0477	Major facilitator Superfamily
U712_12230	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
U712_12235	COG2839	Protein conserved in bacteria
U712_12240	COG5521	maltodextrose utilization protein MalA
U712_12245	COG1388	LysM domain
U712_12250	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
U712_12255	COG4709	membrane
U712_12260	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
U712_12265	COG0735	belongs to the Fur family
U712_12270	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
U712_12280	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
U712_12285	COG0513	Belongs to the DEAD box helicase family
U712_12295	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
U712_12300	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
U712_12305	COG2384	SAM-dependent methyltransferase
U712_12310	COG2010	Cytochrome c
U712_12320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
U712_12325	COG0358	DNA primase activity
U712_12330	COG1671	Belongs to the UPF0178 family
U712_12335	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
U712_12340	COG0517	IMP dehydrogenase activity
U712_12345	COG0751	glycine-tRNA ligase activity
U712_12350	COG0752	glycyl-tRNA synthetase alpha subunit
U712_12355	COG1381	Involved in DNA repair and RecF pathway recombination
U712_12365	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
U712_12370	COG0295	cytidine deaminase activity
U712_12380	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
U712_12385	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
U712_12390	COG1480	7TM receptor with intracellular HD hydrolase
U712_12395	COG1702	phosphate starvation-inducible protein PhoH
U712_12400	COG0561	phosphatase activity
U712_12415	COG4864	UPF0365 protein
U712_12420	COG1030	water channel activity
U712_12425	COG1610	YqeY-like protein
U712_12430	COG0828	Belongs to the bacterial ribosomal protein bS21 family
U712_12435	COG1283	sodium-dependent phosphate transmembrane transporter activity
U712_12440	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
U712_12445	COG1385	rRNA (uridine-N3-)-methyltransferase activity
U712_12450	COG2264	protein methyltransferase activity
U712_12455	COG0484	heat shock protein binding
U712_12460	COG0443	Heat shock 70 kDa protein
U712_12465	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
U712_12470	COG1420	regulation of RNA biosynthetic process
U712_12475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
U712_12480	COG0481	GTPase activity
U712_12490	COG0860	N-Acetylmuramoyl-L-alanine amidase
U712_12495	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
U712_12500	COG0268	Binds directly to 16S ribosomal RNA
U712_12505	COG1466	dna polymerase III delta subunit
U712_12520	COG2333	competence protein COMEC
U712_12520	COG0658	competence protein
U712_12525	COG2131	deaminase
U712_12530	COG1555	photosystem II stabilization
U712_12530	COG1596	polysaccharide export
U712_12535	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
U712_12540	COG2226	methyltransferase
U712_12545	COG0799	negative regulation of ribosome biogenesis
U712_12550	COG1713	HD superfamily hydrolase involved in NAD metabolism
U712_12555	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
U712_12560	COG1534	Rna-binding protein
U712_12565	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
U712_12570	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
U712_12575	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
U712_12585	COG2755	lipolytic protein G-D-S-L family
U712_12590	COG3409	Peptidoglycan-binding domain 1 protein
U712_12590	COG5632	N-Acetylmuramoyl-L-alanine amidase
U712_12595	COG0398	Pfam SNARE associated Golgi protein
U712_12600	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
U712_12610	COG3209	COG3209 Rhs family protein
U712_12615	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
U712_12620	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
U712_12625	COG0798	PFAM Bile acid sodium symporter
U712_12630	COG0346	lactoylglutathione lyase activity
U712_12635	COG0640	Transcriptional regulator
U712_12640	COG3403	YqcI/YcgG family
U712_12645	COG0457	Tetratricopeptide repeat
U712_12660	COG5444	nuclease activity
U712_12680	COG5632	N-Acetylmuramoyl-L-alanine amidase
U712_12680	COG3409	Peptidoglycan-binding domain 1 protein
U712_12685	COG4824	toxin secretion phage lysis holin
U712_12710	COG3778	Protein conserved in bacteria
U712_12715	COG3299	homolog of phage Mu protein gp47
U712_12720	COG3628	GPW Gp25 family protein
U712_12730	COG4193	domain, Protein
U712_12735	COG1652	LysM domain
U712_12740	COG3953	SLT domain
U712_12740	COG5280	Phage tail tape measure protein TP901
U712_12795	COG4653	Phage capsid family
U712_12800	COG0338	D12 class N6 adenine-specific DNA methyltransferase
U712_12810	COG2369	cell adhesion
U712_12815	COG5518	Phage portal protein
U712_12820	COG1783	phage Terminase large subunit
U712_12825	COG5484	DNA packaging
U712_12835	COG3677	Transposase
U712_12850	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
U712_12860	COG1484	DNA-dependent DNA replication
U712_12865	COG3935	DnaD domain protein
U712_12870	COG3723	Recombinational DNA repair protein, rece pathway
U712_12875	COG5377	YqaJ viral recombinase family
U712_12900	COG1476	TRANSCRIPTIONal
U712_12905	COG3620	sequence-specific DNA binding
U712_12915	COG0563	adenylate kinase activity
U712_12920	COG2856	Zn peptidase
U712_12935	COG3223	Belongs to the PsiE family
U712_12940	COG0642	Histidine kinase
U712_12940	COG5002	protein histidine kinase activity
U712_12945	COG0745	RESPONSE REGULATOR receiver
U712_12950	COG2311	Membrane
U712_12960	COG0454	-acetyltransferase
U712_12965	COG2249	NAD(P)H dehydrogenase (quinone) activity
U712_12975	COG0730	response to heat
U712_12980	COG0425	Belongs to the sulfur carrier protein TusA family
U712_12985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
U712_12985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U712_12990	COG0425	Belongs to the sulfur carrier protein TusA family
U712_12990	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
U712_12995	COG2210	Belongs to the sulfur carrier protein TusA family
U712_13000	COG1937	Protein conserved in bacteria
U712_13010	COG0662	Cupin 2, conserved barrel domain protein
U712_13015	COG4978	Transcriptional regulator
U712_13015	COG0789	Transcriptional regulator
U712_13020	COG2814	Major facilitator Superfamily
U712_13025	COG0456	acetyltransferase
U712_13030	COG1253	flavin adenine dinucleotide binding
U712_13040	COG0697	spore germination
U712_13045	COG0583	DNA-binding transcription factor activity
U712_13050	COG2072	flavoprotein involved in K transport
U712_13055	COG1230	cation diffusion facilitator family transporter
U712_13060	COG1942	4-Oxalocrotonate Tautomerase
U712_13065	COG0583	DNA-binding transcription factor activity
U712_13070	COG1114	Component of the transport system for branched-chain amino acids
U712_13075	COG1687	branched-chain amino acid
U712_13080	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
U712_13085	COG1522	sequence-specific DNA binding
U712_13090	COG2732	(Barnase) inhibitor
U712_13095	COG2124	cytochrome p450
U712_13110	COG1335	isochorismatase
U712_13120	COG2318	DinB family
U712_13130	COG2070	2-Nitropropane dioxygenase
U712_13145	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
U712_13160	COG3443	Belongs to the bacterial solute-binding protein 9 family
U712_13165	COG1595	DNA-templated transcription, initiation
U712_13170	COG0667	Aldo Keto reductase
U712_13175	COG2851	Citrate transporter
U712_13180	COG0583	DNA-binding transcription factor activity
U712_13190	COG2828	Protein conserved in bacteria
U712_13195	COG3409	Peptidoglycan-binding domain 1 protein
U712_13200	COG5566	PFAM Mor transcription activator
U712_13205	COG0596	Alpha beta hydrolase
U712_13210	COG4991	sh3 domain protein
U712_13215	COG4991	sh3 domain protein
U712_13220	COG0346	lactoylglutathione lyase activity
U712_13230	COG5577	PFAM Coat F domain
U712_13235	COG1063	alcohol dehydrogenase
U712_13245	COG5577	PFAM Coat F domain
U712_13250	COG0789	Transcriptional regulator
U712_13260	COG1064	alcohol dehydrogenase
U712_13265	COG0693	protein deglycase activity
U712_13270	COG1621	beta-fructofuranosidase activity
U712_13275	COG3716	PTS system mannose fructose sorbose family IID component
U712_13280	COG3715	PTS system
U712_13285	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U712_13290	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
U712_13295	COG3933	PFAM sigma-54 factor interaction domain-containing protein
U712_13295	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
U712_13300	COG1113	amino acid transport
U712_13305	COG1280	lysine exporter protein (LysE YggA)
U712_13310	COG1378	Sugar-specific transcriptional regulator TrmB
U712_13315	COG1595	DNA-templated transcription, initiation
U712_13325	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
U712_13325	COG2755	lipolytic protein G-D-S-L family
U712_13335	COG2124	cytochrome p450
U712_13335	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
U712_13340	COG1309	transcriptional regulator
U712_13345	COG2226	methyltransferase
U712_13370	COG2116	formate transmembrane transporter activity
U712_13375	COG5609	conserved protein (DUF2294)
U712_13380	COG3383	formate dehydrogenase (NAD+) activity
U712_13385	COG2427	Protein of unknown function (DUF1641)
U712_13395	COG0626	cystathionine gamma-synthase activity
U712_13400	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
U712_13405	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
U712_13410	COG2226	methyltransferase
U712_13425	COG0768	penicillin binding
U712_13430	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
U712_13435	COG0572	uridine kinase
U712_13455	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
U712_13460	COG3906	Belongs to the UPF0473 family
U712_13465	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
U712_13470	COG4472	Bacterial protein of unknown function (DUF965)
U712_13475	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
U712_13480	COG0628	permease
U712_13485	COG1126	abc transporter atp-binding protein
U712_13490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U712_13495	COG0765	amino acid transport
U712_13500	COG0765	amino acid transport
U712_13515	COG3881	PFAM PRC-barrel domain
U712_13520	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
U712_13525	COG0457	Tetratricopeptide repeat
U712_13530	COG0482	sulfurtransferase activity
U712_13535	COG1104	cysteine desulfurase activity
U712_13540	COG1959	2 iron, 2 sulfur cluster binding
U712_13545	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
U712_13550	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
U712_13560	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
U712_13565	COG0124	histidyl-tRNA synthetase
U712_13575	COG4991	sh3 domain protein
U712_13575	COG3103	Sh3 type 3 domain protein
U712_13575	COG0860	N-Acetylmuramoyl-L-alanine amidase
U712_13580	COG1490	D-aminoacyl-tRNA deacylase activity
U712_13585	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
U712_13590	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
U712_13595	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
U712_13595	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
U712_13600	COG5416	Lipopolysaccharide assembly protein A domain
U712_13605	COG0490	domain, Protein
U712_13610	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
U712_13610	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
U712_13620	COG2244	polysaccharide biosynthetic process
U712_13625	COG2323	membrane
U712_13635	COG1862	Preprotein translocase
U712_13640	COG0343	queuine tRNA-ribosyltransferase activity
U712_13645	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
U712_13655	COG2255	four-way junction helicase activity
U712_13660	COG0632	four-way junction helicase activity
U712_13670	COG2814	Major facilitator Superfamily
U712_13675	COG0673	inositol 2-dehydrogenase activity
U712_13680	COG2112	serine threonine protein kinase
U712_13700	COG1115	amino acid carrier protein
U712_13705	COG0217	transcriptional regulatory protein
U712_13715	COG1388	LysM domain
U712_13720	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
U712_13725	COG0157	Belongs to the NadC ModD family
U712_13730	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
U712_13735	COG1104	cysteine desulfurase activity
U712_13740	COG1827	regulation of RNA biosynthetic process
U712_13745	COG0077	Prephenate dehydratase
U712_13750	COG4492	Belongs to the UPF0735 family
U712_13755	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
U712_13760	COG3290	protein histidine kinase activity
U712_13770	COG0211	Belongs to the bacterial ribosomal protein bL27 family
U712_13775	COG2868	ribosomal protein
U712_13780	COG0261	This protein binds to 23S rRNA in the presence of protein L20
U712_13785	COG1994	Peptidase M50
U712_13790	COG0739	heme binding
U712_13795	COG2894	cell division
U712_13800	COG0850	regulation of cytokinetic process
U712_13805	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
U712_13810	COG1792	Involved in formation and maintenance of cell shape
U712_13815	COG1077	Cell shape determining protein MreB Mrl
U712_13820	COG2003	Belongs to the UPF0758 family
U712_13825	COG0424	maF-like protein
U712_13835	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
U712_13845	COG0285	dihydrofolate synthase activity
U712_13850	COG0525	valine-tRNA ligase activity
U712_13860	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
U712_13865	COG1388	LysM domain
U712_13870	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
U712_13875	COG0113	porphobilinogen synthase activity
U712_13880	COG1587	Uroporphyrinogen-III synthase
U712_13885	COG0181	hydroxymethylbilane synthase activity
U712_13890	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
U712_13895	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
U712_13905	COG0218	Necessary for normal cell division and for the maintenance of normal septation
U712_13910	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
U712_13915	COG0470	DNA polymerase III
U712_13915	COG1067	ATP-dependent peptidase activity
U712_13920	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
U712_13925	COG0544	peptidyl-prolyl cis-trans isomerase activity
U712_13930	COG0457	Tetratricopeptide repeat
U712_13930	COG1477	protein flavinylation
U712_13940	COG0066	3-isopropylmalate dehydratase activity
U712_13945	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
U712_13950	COG0473	3-isopropylmalate dehydrogenase activity
U712_13955	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
U712_13960	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
U712_13965	COG0440	acetolactate synthase activity
U712_13970	COG0028	Belongs to the TPP enzyme family
U712_13985	COG0454	-acetyltransferase
U712_13995	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
U712_14000	COG0622	Phosphoesterase
U712_14005	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
U712_14010	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
U712_14015	COG5401	PFAM Sporulation and spore germination
U712_14020	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
U712_14025	COG1846	Transcriptional regulator
U712_14035	COG2197	response regulator
U712_14040	COG0824	Thioesterase
U712_14045	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
U712_14050	COG1053	succinate dehydrogenase
U712_14055	COG2009	succinate dehydrogenase
U712_14060	COG1719	4-vinyl reductase, 4VR
U712_14065	COG0527	aspartate kinase activity
U712_14070	COG0322	excinuclease ABC activity
U712_14075	COG3118	belongs to the thioredoxin family
U712_14090	COG3534	alpha-L-arabinofuranosidase
U712_14100	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
U712_14105	COG2086	electron transfer activity
U712_14110	COG1024	Enoyl-CoA hydratase
U712_14115	COG1309	transcriptional regulator
U712_14120	COG0318	PFAM AMP-dependent synthetase and ligase
U712_14125	COG3766	membrane
U712_14130	COG1193	negative regulation of DNA recombination
U712_14135	COG1796	DNA polymerase
U712_14135	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
U712_14140	COG1286	toxin biosynthetic process
U712_14145	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
U712_14150	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
U712_14155	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U712_14155	COG0072	phenylalanine-tRNA ligase activity
U712_14160	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
U712_14170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
U712_14180	COG3835	regulator
U712_14185	COG0277	FAD linked oxidase domain protein
U712_14190	COG0247	lactate metabolic process
U712_14195	COG0346	lactoylglutathione lyase activity
U712_14200	COG1966	Carbon starvation protein
U712_14205	COG3534	alpha-L-arabinofuranosidase
U712_14210	COG0395	ABC-type sugar transport system, permease component
U712_14215	COG1175	transmembrane transport
U712_14220	COG1653	transport
U712_14225	COG0371	Dehydrogenase
U712_14230	COG0647	UMP catabolic process
U712_14235	COG0235	Class ii aldolase
U712_14240	COG1069	ribulokinase activity
U712_14245	COG2160	L-arabinose isomerase activity
U712_14250	COG3507	Belongs to the glycosyl hydrolase 43 family
U712_14255	COG1363	Peptidase, m42
U712_14265	COG3326	Membrane
U712_14270	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
U712_14275	COG0291	Belongs to the bacterial ribosomal protein bL35 family
U712_14280	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
U712_14295	COG1346	cytolysis
U712_14300	COG1380	Effector of murein hydrolase LrgA
U712_14305	COG3279	Response regulator of the LytR AlgR family
U712_14310	COG3275	phosphorelay sensor kinase activity
U712_14320	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
U712_14335	COG0398	Pfam SNARE associated Golgi protein
U712_14340	COG1484	DNA-dependent DNA replication
U712_14345	COG3611	Membrane attachment protein
U712_14350	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
U712_14355	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
U712_14360	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
U712_14365	COG1733	regulation of RNA biosynthetic process
U712_14370	COG2814	Major facilitator Superfamily
U712_14375	COG0656	L-ascorbic acid biosynthetic process
U712_14380	COG0237	dephospho-CoA kinase activity
U712_14385	COG1971	Probably functions as a manganese efflux pump
U712_14390	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
U712_14395	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
U712_14395	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
U712_14400	COG5002	protein histidine kinase activity
U712_14405	COG0745	RESPONSE REGULATOR receiver
U712_14415	COG0039	L-malate dehydrogenase activity
U712_14420	COG0538	isocitrate dehydrogenase activity
U712_14425	COG0372	Belongs to the citrate synthase family
U712_14435	COG2707	UPF0756 membrane protein
U712_14440	COG0628	permease
U712_14445	COG3030	protein affecting phage T7 exclusion by the F plasmid
U712_14450	COG0469	pyruvate kinase activity
U712_14455	COG0205	6-phosphofructokinase activity
U712_14465	COG0825	malonyl-CoA metabolic process
U712_14470	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
U712_14475	COG0281	malic enzyme
U712_14480	COG0587	DNA-directed DNA polymerase activity
U712_14500	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
U712_14515	COG4109	DRTGG domain
U712_14520	COG0730	response to heat
U712_14525	COG1473	amidohydrolase
U712_14530	COG0196	riboflavin kinase activity
U712_14535	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
U712_14540	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
U712_14545	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
U712_14550	COG1126	abc transporter atp-binding protein
U712_14555	COG0765	amino acid transport
U712_14560	COG0765	amino acid transport
U712_14565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U712_14570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U712_14575	COG0454	-acetyltransferase
U712_14580	COG0583	DNA-binding transcription factor activity
U712_14585	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
U712_14590	COG1028	Short-chain dehydrogenase reductase Sdr
U712_14600	COG0165	Argininosuccinate lyase
U712_14605	COG0137	argininosuccinate synthase activity
U712_14610	COG0521	Mo-molybdopterin cofactor biosynthetic process
U712_14615	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
U712_14625	COG0827	DNA restriction-modification system
U712_14630	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
U712_14635	COG3874	Sporulation protein YtfJ
U712_14645	COG1714	RDD family
U712_14650	COG0616	signal peptide processing
U712_14660	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
U712_14665	COG1574	metal-dependent hydrolase with the TIM-barrel fold
U712_14670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
U712_14680	COG0301	tRNA thio-modification
U712_14685	COG1104	cysteine desulfurase activity
U712_14690	COG1114	Component of the transport system for branched-chain amino acids
U712_14695	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
U712_14700	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
U712_14705	COG1309	transcriptional regulator
U712_14710	COG1956	GAF domain-containing protein
U712_14715	COG2199	diguanylate cyclase activity
U712_14715	COG2203	Gaf domain
U712_14725	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
U712_14735	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
U712_14740	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
U712_14745	COG0454	-acetyltransferase
U712_14750	COG0517	IMP dehydrogenase activity
U712_14755	COG0123	including yeast histone deacetylase and acetoin utilization protein
U712_14760	COG1360	Flagellar Motor Protein
U712_14765	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
U712_14770	COG1609	Transcriptional regulator
U712_14775	COG1605	Chorismate mutase
U712_14775	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
U712_14780	COG3118	belongs to the thioredoxin family
U712_14785	COG4980	gas vesicle protein
U712_14790	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
U712_14795	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
U712_14800	COG1674	ftsk spoiiie
U712_14805	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
U712_14810	COG4848	Belongs to the UPF0354 family
U712_14815	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U712_14830	COG1363	Peptidase, m42
U712_14835	COG5584	Small secreted protein
U712_14840	COG0281	malic enzyme
U712_14845	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U712_14850	COG0220	tRNA (guanine-N7-)-methyltransferase activity
U712_14860	COG0510	thiamine kinase activity
U712_14865	COG1523	belongs to the glycosyl hydrolase 13 family
U712_14870	COG1597	lipid kinase activity
U712_14880	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
U712_14885	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
U712_14890	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
U712_14895	COG2252	PERMEase
U712_14900	COG4473	ABC transporter
U712_14905	COG1131	(ABC) transporter
U712_14910	COG1349	DNA-binding transcription factor activity
U712_14915	COG1187	pseudouridine synthase activity
U712_14920	COG2244	polysaccharide biosynthetic process
U712_14925	COG2081	HI0933 family
U712_14930	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
U712_14940	COG5578	integral membrane protein
U712_14945	COG0673	inositol 2-dehydrogenase activity
U712_14950	COG1653	transport
U712_14955	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
U712_14960	COG4209	transmembrane transport
U712_14965	COG2207	Transcriptional regulator
U712_14970	COG1653	transport
U712_14975	COG0395	ABC-type sugar transport system, permease component
U712_14980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
U712_14985	COG2124	cytochrome p450
U712_14990	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
U712_14995	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
U712_15000	COG0156	8-amino-7-oxononanoate synthase activity
U712_15005	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
U712_15010	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
U712_15015	COG1073	alpha beta
U712_15040	COG1486	melibiose metabolic process
U712_15045	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
U712_15050	COG0495	leucyl-tRNA aminoacylation
U712_15065	COG2202	Pas domain
U712_15065	COG1366	Belongs to the anti-sigma-factor antagonist family
U712_15070	COG2814	Major facilitator Superfamily
U712_15075	COG2433	Pfam Transposase IS66
U712_15080	COG0577	efflux transmembrane transporter activity
U712_15085	COG1136	(ABC) transporter
U712_15090	COG2205	protein histidine kinase activity
U712_15095	COG0745	RESPONSE REGULATOR receiver
U712_15100	COG0577	efflux transmembrane transporter activity
U712_15105	COG1136	(ABC) transporter
U712_15120	COG1131	(ABC) transporter
U712_15125	COG1725	Transcriptional regulator
U712_15140	COG1242	4 iron, 4 sulfur cluster binding
U712_15145	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
U712_15155	COG2267	carboxylic ester hydrolase activity
U712_15160	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
U712_15165	COG1113	amino acid transport
U712_15170	COG0367	asparagine synthase
U712_15175	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
U712_15180	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
U712_15190	COG1506	peptidase
U712_15195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
U712_15200	COG1116	anion transmembrane transporter activity
U712_15205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
U712_15210	COG0494	nUDIX hydrolase
U712_15215	COG4824	toxin secretion phage lysis holin
U712_15220	COG0783	Belongs to the Dps family
U712_15235	COG1854	S-ribosylhomocysteine lyase activity
U712_15240	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
U712_15245	COG0288	reversible hydration of carbon dioxide
U712_15250	COG0254	rRNA binding
U712_15255	COG1271	oxidase subunit
U712_15260	COG1294	oxidase, subunit
U712_15270	COG1108	ABC-type Mn2 Zn2 transport systems permease components
U712_15275	COG1321	iron dependent repressor
U712_15275	COG1108	ABC-type Mn2 Zn2 transport systems permease components
U712_15280	COG1121	(ABC) transporter
U712_15285	COG0803	Belongs to the bacterial solute-binding protein 9 family
U712_15290	COG4948	Mandelate Racemase Muconate Lactonizing
U712_15295	COG0318	PFAM AMP-dependent synthetase and ligase
U712_15300	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
U712_15305	COG0596	Alpha beta hydrolase
U712_15310	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
U712_15315	COG1169	isochorismate synthase
U712_15320	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
U712_15325	COG1210	Utp--glucose-1-phosphate uridylyltransferase
U712_15330	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
U712_15335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
U712_15340	COG0438	transferase activity, transferring glycosyl groups
U712_15350	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
U712_15355	COG0438	transferase activity, transferring glycosyl groups
U712_15360	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
U712_15365	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
U712_15370	COG0058	SHG alpha-glucan phosphorylase activity
U712_15375	COG0297	glycogen (starch) synthase activity
U712_15380	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
U712_15385	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
U712_15390	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
U712_15395	COG3859	Proton-coupled thiamine transporter YuaJ
U712_15400	COG1247	-acetyltransferase
U712_15405	COG2268	Band 7 protein
U712_15410	COG1585	Membrane protein implicated in regulation of membrane protease activity
U712_15415	COG2318	DinB family
U712_15425	COG1454	alcohol dehydrogenase
U712_15435	COG1510	regulation of RNA biosynthetic process
U712_15445	COG0569	domain protein
U712_15450	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
U712_15455	COG4682	membrane
U712_15460	COG1705	Flagellar rod assembly protein muramidase FlgJ
U712_15465	COG0477	Major facilitator Superfamily
U712_15470	COG5553	Cysteine dioxygenase type I
U712_15480	COG1968	undecaprenyl-diphosphatase activity
U712_15485	COG0628	permease
U712_15490	COG0673	inositol 2-dehydrogenase activity
U712_15495	COG4806	L-rhamnose isomerase
U712_15500	COG3254	rhamnose metabolic process
U712_15505	COG1070	Carbohydrate kinase
U712_15510	COG1349	DNA-binding transcription factor activity
U712_15515	COG3347	Dehydrogenase
U712_15515	COG1028	Short-chain dehydrogenase reductase Sdr
U712_15525	COG0840	transmembrane signaling receptor activity
U712_15530	COG0840	transmembrane signaling receptor activity
U712_15535	COG0840	transmembrane signaling receptor activity
U712_15540	COG0840	transmembrane signaling receptor activity
U712_15560	COG0432	Pfam Uncharacterised protein family UPF0047
U712_15570	COG0366	Alpha amylase catalytic
U712_15575	COG1253	flavin adenine dinucleotide binding
U712_15580	COG2738	Putative neutral zinc metallopeptidase
U712_15595	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
U712_15610	COG0166	Belongs to the GPI family
U712_15615	COG1979	alcohol dehydrogenase
U712_15620	COG1979	alcohol dehydrogenase
U712_15625	COG2155	Conserved Protein
U712_15630	COG1098	S1 RNA binding domain
U712_15635	COG0436	Aminotransferase
U712_15640	COG1522	sequence-specific DNA binding
U712_15645	COG2267	carboxylic ester hydrolase activity
U712_15655	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
U712_15660	COG2205	protein histidine kinase activity
U712_15680	COG2814	Major facilitator Superfamily
U712_15685	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
U712_15690	COG3011	Protein conserved in bacteria
U712_15700	COG3290	protein histidine kinase activity
U712_15705	COG4565	transcriptional regulatory protein
U712_15730	COG3493	citrate carrier protein
U712_15740	COG2111	Na H antiporter
U712_15740	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
U712_15745	COG2111	Na H antiporter
U712_15750	COG1006	Multisubunit Na H antiporter MnhC subunit
U712_15755	COG0651	ATP synthesis coupled electron transport
U712_15760	COG1863	multisubunit Na H antiporter MnhE subunit
U712_15765	COG2212	antiporter activity
U712_15770	COG1320	monovalent cation:proton antiporter activity
U712_15775	COG2050	protein possibly involved in aromatic compounds catabolism
U712_15780	COG2197	response regulator
U712_15785	COG4585	Histidine kinase
U712_15795	COG0142	geranyltranstransferase activity
U712_15815	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
U712_15820	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
U712_15825	COG1335	isochorismatase
U712_15830	COG5506	Protein of unknown function (DUF1694)
U712_15845	COG0628	permease
U712_15860	COG1418	mRNA catabolic process
U712_15865	COG1028	Short-chain dehydrogenase reductase Sdr
U712_15875	COG1511	domain protein
U712_15880	COG0433	COG0433 Predicted ATPase
U712_15880	COG1674	ftsk spoiiie
U712_15885	COG4499	WXG100 protein secretion system (Wss), protein YukC
U712_15890	COG5417	Belongs to the EsaB family
U712_15895	COG4842	Belongs to the WXG100 family
U712_15905	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
U712_15905	COG2508	Transcriptional regulator
U712_15910	COG0686	Belongs to the AlaDH PNT family
U712_15915	COG5634	Uncharacterized conserved protein (DUF2278)
U712_15920	COG3251	PFAM MbtH domain protein
U712_15925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U712_15930	COG1535	isochorismatase
U712_15930	COG3433	isochorismatase activity
U712_15935	COG1021	2,3-dihydroxybenzoate-AMP ligase
U712_15940	COG1169	isochorismate synthase
U712_15945	COG1028	Short-chain dehydrogenase reductase Sdr
U712_15950	COG2819	hydrolase of the alpha beta superfamily
U712_15955	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
U712_15960	COG1268	BioY protein
U712_15965	COG2056	Na+-H+ antiporter family
U712_15970	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
U712_15975	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
U712_15980	COG3584	3D domain protein
U712_15995	COG1252	NADH dehydrogenase
U712_16005	COG0492	ferredoxin-NADP+ reductase activity
U712_16015	COG0516	GMP reductase activity
U712_16020	COG2808	Putative FMN-binding domain
U712_16025	COG0456	acetyltransferase
U712_16030	COG0316	Belongs to the HesB IscA family
U712_16035	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
U712_16040	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
U712_16045	COG4844	belongs to the
U712_16050	COG1252	NADH dehydrogenase
U712_16055	COG4837	Protein of unknown function (DUF1462)
U712_16060	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
U712_16065	COG0823	Involved in the tonB-independent uptake of proteins
U712_16065	COG1506	peptidase
U712_16065	COG4946	Tricorn protease homolog
U712_16070	COG0083	homoserine kinase activity
U712_16075	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
U712_16080	COG0460	homoserine dehydrogenase
U712_16085	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
U712_16095	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
U712_16100	COG0647	UMP catabolic process
U712_16105	COG2445	Protein of unknown function DUF86
U712_16110	COG4470	Protein conserved in bacteria
U712_16120	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
U712_16125	COG0739	heme binding
U712_16135	COG3377	Domain of unknown function (DUF1805)
U712_16140	COG0737	Belongs to the 5'-nucleotidase family
U712_16145	COG0730	response to heat
U712_16150	COG1801	Protein of unknown function DUF72
U712_16160	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
U712_16165	COG2508	Transcriptional regulator
U712_16170	COG2233	PERMEase
U712_16175	COG2233	PERMEase
U712_16180	COG3195	allantoin biosynthetic process
U712_16180	COG3648	Uricase
U712_16185	COG2351	hydroxyisourate hydrolase activity
U712_16195	COG2080	2 iron, 2 sulfur cluster binding
U712_16200	COG1529	Aldehyde oxidase and xanthine dehydrogenase
U712_16205	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
U712_16210	COG2068	MobA-Related Protein
U712_16215	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
U712_16220	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
U712_16225	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
U712_16235	COG2356	endonuclease I
U712_16240	COG3842	ATPase activity
U712_16245	COG2188	Transcriptional regulator
U712_16250	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U712_16255	COG0395	ABC-type sugar transport system, permease component
U712_16260	COG1175	transmembrane transport
U712_16265	COG1653	transport
U712_16270	COG2222	sugar isomerase
U712_16275	COG0322	excinuclease ABC activity
U712_16280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
U712_16295	COG0346	lactoylglutathione lyase activity
U712_16300	COG0719	Fe-S assembly protein
U712_16305	COG0822	iron-sulfur transferase activity
U712_16310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
U712_16315	COG0719	Fe-S assembly protein
U712_16320	COG0396	ATPase activity
U712_16340	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
U712_16345	COG1464	Belongs to the NlpA lipoprotein family
U712_16350	COG2011	ABC-type metal ion transport system permease component
U712_16355	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
U712_16370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
U712_16375	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
U712_16385	COG0509	glycine decarboxylation via glycine cleavage system
U712_16390	COG1393	Belongs to the ArsC family
U712_16395	COG1960	acyl-CoA dehydrogenase activity
U712_16400	COG0183	Belongs to the thiolase family
U712_16405	COG1250	3-hydroxyacyl-CoA dehydrogenase
U712_16405	COG1024	Enoyl-CoA hydratase
U712_16415	COG0506	proline dehydrogenase activity
U712_16425	COG5577	PFAM Coat F domain
U712_16430	COG1846	Transcriptional regulator
U712_16435	COG0477	Major facilitator Superfamily
U712_16440	COG1942	4-Oxalocrotonate Tautomerase
U712_16450	COG0583	DNA-binding transcription factor activity
U712_16460	COG1120	ATPase activity
U712_16475	COG1028	Short-chain dehydrogenase reductase Sdr
U712_16480	COG0783	Belongs to the Dps family
U712_16485	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
U712_16490	COG0745	RESPONSE REGULATOR receiver
U712_16495	COG2770	Histidine kinase
U712_16495	COG2205	protein histidine kinase activity
U712_16505	COG1309	transcriptional regulator
U712_16510	COG0114	fumarate hydratase activity
U712_16520	COG0697	spore germination
U712_16525	COG0814	amino acid
U712_16535	COG2197	response regulator
U712_16540	COG4585	Histidine kinase
U712_16545	COG4758	membrane
U712_16550	COG3595	metallopeptidase activity
U712_16555	COG1842	Phage shock protein A
U712_16560	COG4758	membrane
U712_16570	COG2814	Major facilitator Superfamily
U712_16575	COG2096	Adenosyltransferase
U712_16580	COG1120	ATPase activity
U712_16585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U712_16590	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
U712_16600	COG1028	Short-chain dehydrogenase reductase Sdr
U712_16605	COG3386	PFAM SMP-30 Gluconolaconase
U712_16610	COG2205	protein histidine kinase activity
U712_16620	COG1191	sigma factor activity
U712_16635	COG2140	Oxalate decarboxylase
U712_16645	COG0577	efflux transmembrane transporter activity
U712_16650	COG1136	(ABC) transporter
U712_16655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
U712_16660	COG1120	ATPase activity
U712_16665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U712_16670	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
U712_16675	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
U712_16685	COG0531	amino acid
U712_16695	COG1988	membrane-bound metal-dependent
U712_16700	COG1368	sulfuric ester hydrolase activity
U712_16705	COG0725	ABC transporter, periplasmic molybdate-binding protein
U712_16710	COG4149	molybdate abc transporter
U712_16715	COG0656	L-ascorbic acid biosynthetic process
U712_16725	COG0025	NhaP-type Na H and K H
U712_16730	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
U712_16735	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
U712_16740	COG3973	AAA domain
U712_16745	COG2860	membrane
U712_16755	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
U712_16760	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
U712_16765	COG2217	Heavy metal translocating P-type atpase
U712_16770	COG2217	Heavy metal translocating P-type atpase
U712_16775	COG2608	mercury ion transmembrane transporter activity
U712_16780	COG1937	Protein conserved in bacteria
U712_16785	COG0673	inositol 2-dehydrogenase activity
U712_16790	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
U712_16795	COG1289	transmembrane transporter activity
U712_16805	COG2076	Multidrug Resistance protein
U712_16810	COG1309	transcriptional regulator
U712_16815	COG1028	Short-chain dehydrogenase reductase Sdr
U712_16820	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
U712_16825	COG0557	exoribonuclease II activity
U712_16830	COG1647	Serine aminopeptidase, S33
U712_16835	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
U712_16840	COG0596	Alpha beta hydrolase
U712_16845	COG1476	TRANSCRIPTIONal
U712_16850	COG1396	sequence-specific DNA binding
U712_16855	COG1733	regulation of RNA biosynthetic process
U712_16860	COG0840	transmembrane signaling receptor activity
U712_16865	COG1174	glycine betaine transport
U712_16870	COG1732	Glycine betaine
U712_16875	COG1174	glycine betaine transport
U712_16880	COG1125	glycine betaine transport
U712_16880	COG0517	IMP dehydrogenase activity
U712_16885	COG1510	regulation of RNA biosynthetic process
U712_16900	COG5658	integral membrane protein
U712_16905	COG0640	Transcriptional regulator
U712_16910	COG1174	glycine betaine transport
U712_16915	COG1732	Glycine betaine
U712_16920	COG1174	glycine betaine transport
U712_16925	COG0517	IMP dehydrogenase activity
U712_16925	COG1125	glycine betaine transport
U712_16930	COG1510	regulation of RNA biosynthetic process
U712_16935	COG2095	MarC family integral membrane protein
U712_16945	COG3064	Membrane
U712_16950	COG4640	response to antibiotic
U712_16955	COG0456	acetyltransferase
U712_16960	COG0148	phosphopyruvate hydratase activity
U712_16965	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
U712_16970	COG0149	triose-phosphate isomerase activity
U712_16975	COG0126	phosphoglycerate kinase activity
U712_16980	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
U712_16985	COG2390	Transcriptional regulator
U712_16990	COG2814	Major facilitator Superfamily
U712_16995	COG1609	Transcriptional regulator
U712_17000	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
U712_17005	COG0583	DNA-binding transcription factor activity
U712_17010	COG0697	spore germination
U712_17015	COG1113	amino acid transport
U712_17020	COG3858	chitin binding
U712_17025	COG1556	Lactate utilization protein
U712_17030	COG1139	Iron-sulfur cluster binding protein
U712_17035	COG0247	lactate metabolic process
U712_17040	COG2197	response regulator
U712_17045	COG4585	Histidine kinase
U712_17050	COG0842	Transport permease protein
U712_17055	COG1131	(ABC) transporter
U712_17065	COG0596	Alpha beta hydrolase
U712_17070	COG2208	phosphoserine phosphatase activity
U712_17075	COG3867	Arabinogalactan endo-beta-1,4-galactanase
U712_17080	COG1874	Beta-galactosidase
U712_17085	COG3833	ABC-type maltose transport systems, permease component
U712_17090	COG1175	transmembrane transport
U712_17095	COG2182	Extracellular solute-binding protein
U712_17100	COG1609	Transcriptional regulator
U712_17105	COG2186	Transcriptional regulator
U712_17110	COG1620	l-lactate permease
U712_17115	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
U712_17130	COG5039	Polysaccharide pyruvyl transferase
U712_17135	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
U712_17140	COG0110	maltose O-acetyltransferase activity
U712_17145	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
U712_17150	COG2244	polysaccharide biosynthetic process
U712_17155	COG1216	Glycosyl transferase, family 2
U712_17160	COG5039	Polysaccharide pyruvyl transferase
U712_17165	COG1216	Glycosyl transferase, family 2
U712_17175	COG0438	transferase activity, transferring glycosyl groups
U712_17180	COG1215	transferase activity, transferring glycosyl groups
U712_17185	COG0438	transferase activity, transferring glycosyl groups
U712_17190	COG1086	Polysaccharide biosynthesis protein
U712_17195	COG0489	protein tyrosine kinase activity
U712_17200	COG3944	biosynthesis protein
U712_17205	COG1396	sequence-specific DNA binding
U712_17210	COG2272	Belongs to the type-B carboxylesterase lipase family
U712_17220	COG3479	Phenolic acid decarboxylase
U712_17235	COG1794	racemase activity, acting on amino acids and derivatives
U712_17240	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
U712_17245	COG1621	beta-fructofuranosidase activity
U712_17250	COG1621	beta-fructofuranosidase activity
U712_17255	COG0531	amino acid
U712_17260	COG1309	transcriptional regulator
U712_17265	COG2076	Multidrug Resistance protein
U712_17270	COG2076	Multidrug Resistance protein
U712_17280	COG0277	FAD linked oxidase domain protein
U712_17285	COG3621	Patatin-like phospholipase
U712_17290	COG0740	serine-type endopeptidase activity
U712_17295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
U712_17300	COG0366	Alpha amylase catalytic
U712_17305	COG1554	hydrolase, family 65, central catalytic
U712_17310	COG5521	maltodextrose utilization protein MalA
U712_17315	COG3833	ABC-type maltose transport systems, permease component
U712_17320	COG1175	transmembrane transport
U712_17325	COG2182	Extracellular solute-binding protein
U712_17330	COG0366	Alpha amylase catalytic
U712_17335	COG1609	Transcriptional regulator
U712_17340	COG1611	Belongs to the LOG family
U712_17345	COG1694	Mazg nucleotide pyrophosphohydrolase
U712_17350	COG0659	secondary active sulfate transmembrane transporter activity
U712_17355	COG0288	reversible hydration of carbon dioxide
U712_17360	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
U712_17365	COG0577	efflux transmembrane transporter activity
U712_17370	COG1136	(ABC) transporter
U712_17375	COG5002	protein histidine kinase activity
U712_17380	COG0745	RESPONSE REGULATOR receiver
U712_17390	COG2162	N-hydroxyarylamine O-acetyltransferase activity
U712_17395	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
U712_17400	COG1481	regulation of sporulation
U712_17405	COG0391	Required for morphogenesis under gluconeogenic growth conditions
U712_17410	COG1660	Displays ATPase and GTPase activities
U712_17415	COG1051	belongs to the nudix hydrolase family
U712_17420	COG0492	ferredoxin-NADP+ reductase activity
U712_17425	COG3883	PFAM NLP P60 protein
U712_17425	COG0791	NLP P60 protein
U712_17430	COG0457	Tetratricopeptide repeat
U712_17435	COG1132	(ABC) transporter
U712_17455	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
U712_17455	COG0140	phosphoribosyl-ATP diphosphatase activity
U712_17460	COG0107	imidazoleglycerol-phosphate synthase activity
U712_17465	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
U712_17470	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
U712_17475	COG0131	Imidazoleglycerol-phosphate dehydratase
U712_17480	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
U712_17485	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
U712_17490	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
U712_17495	COG4990	cell redox homeostasis
U712_17500	COG5297	Belongs to the glycosyl hydrolase family 6
U712_17505	COG0110	maltose O-acetyltransferase activity
U712_17510	COG0546	phosphoglycolate phosphatase activity
U712_17515	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
U712_17520	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
U712_17525	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
U712_17530	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
U712_17535	COG0363	glucosamine-6-phosphate deaminase activity
U712_17545	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
U712_17555	COG1846	Transcriptional regulator
U712_17560	COG2124	cytochrome p450
U712_17575	COG1846	Transcriptional regulator
U712_17580	COG2814	Major facilitator Superfamily
U712_17585	COG1950	PFAM Membrane protein of
U712_17590	COG1983	PspC domain protein
U712_17595	COG3595	metallopeptidase activity
U712_17610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
U712_17615	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
U712_17620	COG0556	nucleotide-excision repair
U712_17625	COG4897	Protein conserved in bacteria
U712_17640	COG0574	Belongs to the PEP-utilizing enzyme family
U712_17640	COG3848	Pyruvate phosphate dikinase
U712_17645	COG1309	transcriptional regulator
U712_17650	COG2814	Major facilitator Superfamily
U712_17655	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
U712_17665	COG0793	Belongs to the peptidase S41A family
U712_17665	COG3409	Peptidoglycan-binding domain 1 protein
U712_17670	COG2177	Part of the ABC transporter FtsEX involved in
U712_17675	COG2884	Cell division ATP-binding protein ftsE
U712_17680	COG2010	Cytochrome c
U712_17685	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
U712_17690	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
U712_17695	COG0653	protein targeting
U712_17700	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
U712_17715	COG1516	flagellar protein fliS
U712_17720	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
U712_17725	COG1334	flagellar protein FlaG
U712_17730	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
U712_17735	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
U712_17740	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
U712_17750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
U712_17755	COG1256	bacterial-type flagellum assembly
U712_17755	COG4786	Flagellar basal body rod
U712_17760	COG3418	PFAM FlgN family protein
U712_17765	COG2747	anti-sigma28 factor FlgM
U712_17775	COG1040	competence protein
U712_17785	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
U712_17790	COG1307	EDD domain protein, DegV family
U712_17795	COG2197	response regulator
U712_17800	COG4585	Histidine kinase
U712_17805	COG1739	Uncharacterized protein family UPF0029
U712_17810	COG1316	TRANSCRIPTIONal
U712_17815	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
U712_17820	COG0438	transferase activity, transferring glycosyl groups
U712_17825	COG1215	transferase activity, transferring glycosyl groups
U712_17830	COG3206	protein involved in exopolysaccharide biosynthesis
U712_17835	COG3307	-O-antigen
U712_17840	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
U712_17845	COG0438	transferase activity, transferring glycosyl groups
U712_17845	COG0297	glycogen (starch) synthase activity
U712_17850	COG2244	polysaccharide biosynthetic process
U712_17860	COG0860	N-Acetylmuramoyl-L-alanine amidase
U712_17860	COG2247	cell wall binding repeat
U712_17865	COG2247	cell wall binding repeat
U712_17865	COG2385	sporulation resulting in formation of a cellular spore
U712_17875	COG1316	TRANSCRIPTIONal
U712_17880	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
U712_17890	COG1210	Utp--glucose-1-phosphate uridylyltransferase
U712_17895	COG1682	transport, permease protein
U712_17900	COG1215	transferase activity, transferring glycosyl groups
U712_17900	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
U712_17905	COG0463	Glycosyl transferase, family 2
U712_17915	COG1210	Utp--glucose-1-phosphate uridylyltransferase
U712_17920	COG1134	teichoic acid transport
U712_17925	COG1682	transport, permease protein
U712_17930	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
U712_17935	COG0438	transferase activity, transferring glycosyl groups
U712_17940	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
U712_17945	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
U712_17950	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
U712_17960	COG4193	domain, Protein
U712_17965	COG1482	cell wall glycoprotein biosynthetic process
U712_17975	COG0697	spore germination
U712_17980	COG0814	amino acid
U712_17990	COG2814	Major facilitator Superfamily
U712_17995	COG1316	TRANSCRIPTIONal
U712_18000	COG0561	phosphatase activity
U712_18005	COG0791	NLP P60 protein
U712_18015	COG2843	Capsule synthesis protein
U712_18025	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
U712_18035	COG1609	Transcriptional regulator
U712_18040	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U712_18045	COG1869	D-ribose catabolic process
U712_18050	COG1129	ABC transporter
U712_18055	COG1879	ABC-type sugar transport system periplasmic component
U712_18060	COG3103	Sh3 type 3 domain protein
U712_18070	COG2249	NAD(P)H dehydrogenase (quinone) activity
U712_18075	COG3527	Alpha-acetolactate decarboxylase
U712_18080	COG0028	Belongs to the TPP enzyme family
U712_18085	COG0583	DNA-binding transcription factor activity
U712_18090	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
U712_18105	COG5337	Spore coat protein CotH
U712_18110	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
U712_18120	COG0405	Gamma-glutamyltransferase
U712_18125	COG1522	sequence-specific DNA binding
U712_18130	COG2059	Chromate
U712_18135	COG2059	Chromate
U712_18145	COG0655	NAD(P)H dehydrogenase (quinone) activity
U712_18150	COG0583	DNA-binding transcription factor activity
U712_18155	COG1515	deoxyribonuclease V activity
U712_18160	COG2849	repeat protein
U712_18165	COG5444	nuclease activity
U712_18185	COG3878	Protein conserved in bacteria
U712_18190	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
U712_18195	COG4464	protein tyrosine phosphatase activity
U712_18200	COG0489	protein tyrosine kinase activity
U712_18205	COG3944	biosynthesis protein
U712_18215	COG4715	Zinc finger, swim domain protein
U712_18220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
U712_18225	COG0561	phosphatase activity
U712_18230	COG1349	DNA-binding transcription factor activity
U712_18235	COG0629	single-stranded DNA binding
U712_18255	COG3764	Sortase (surface protein transpeptidase)
U712_18265	COG0745	RESPONSE REGULATOR receiver
U712_18265	COG2972	Histidine kinase
U712_18270	COG1970	mechanosensitive ion channel activity
U712_18275	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
U712_18280	COG0457	Tetratricopeptide repeat
U712_18285	COG4786	Flagellar basal body rod
U712_18290	COG4786	Flagellar basal body rod
U712_18295	COG1077	Cell shape determining protein MreB Mrl
U712_18300	COG1609	Transcriptional regulator
U712_18305	COG1846	Transcriptional regulator
U712_18310	COG2814	Major facilitator Superfamily
U712_18315	COG3420	alginic acid biosynthetic process
U712_18320	COG1953	Uracil, thiamine, allantoin
U712_18325	COG0477	Major facilitator Superfamily
U712_18330	COG1335	isochorismatase
U712_18345	COG0004	ammonium transporteR
U712_18350	COG0347	Belongs to the P(II) protein family
U712_18355	COG0671	phosphoesterase, PA-phosphatase related
U712_18365	COG0739	heme binding
U712_18370	COG1247	-acetyltransferase
U712_18395	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
U712_18400	COG0789	Transcriptional regulator
U712_18410	COG2910	NAD(P)H-binding
U712_18415	COG1959	2 iron, 2 sulfur cluster binding
U712_18420	COG0804	urea catabolic process
U712_18425	COG0832	Belongs to the urease beta subunit family
U712_18430	COG0831	urea catabolic process
U712_18440	COG3237	CsbD-like
U712_18445	COG1994	Peptidase M50
U712_18455	COG0457	Tetratricopeptide repeat
U712_18465	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
U712_18470	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
U712_18480	COG2304	oxidoreductase activity
U712_18490	COG2304	oxidoreductase activity
U712_18500	COG2385	sporulation resulting in formation of a cellular spore
U712_18505	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
U712_18515	COG4836	Membrane
U712_18525	COG0355	proton-transporting ATP synthase activity, rotational mechanism
U712_18530	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
U712_18535	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
U712_18540	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
U712_18545	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
U712_18550	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
U712_18555	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
U712_18560	COG0356	it plays a direct role in the translocation of protons across the membrane
U712_18570	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
U712_18575	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
U712_18580	COG4475	Protein of unknown function (DUF436)
U712_18585	COG0698	ribose 5-phosphate isomerase
U712_18595	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
U712_18600	COG1971	Probably functions as a manganese efflux pump
U712_18605	COG0009	L-threonylcarbamoyladenylate synthase
U712_18610	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
U712_18630	COG2890	protein-(glutamine-N5) methyltransferase activity
U712_18635	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
U712_18640	COG0346	lactoylglutathione lyase activity
U712_18645	COG0789	Transcriptional regulator
U712_18650	COG0679	Auxin Efflux Carrier
U712_18655	COG0281	malic enzyme
U712_18665	COG1435	thymidine kinase activity
U712_18670	COG0254	rRNA binding
U712_18675	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
U712_18685	COG1494	fructose-1,6-bisphosphatase
U712_18690	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
U712_18695	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
U712_18700	COG0191	fructose-bisphosphate aldolase activity
U712_18705	COG2204	response regulator
U712_18710	COG4821	SIS domain
U712_18715	COG0504	CTP synthase activity
U712_18720	COG3343	RNA polymerase activity
U712_18730	COG1960	acyl-CoA dehydrogenase activity
U712_18735	COG2181	nitrate reductase activity
U712_18735	COG0247	lactate metabolic process
U712_18740	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
U712_18745	COG4294	response to UV
U712_18755	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
U712_18760	COG1132	(ABC) transporter
U712_18765	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
U712_18775	COG2181	nitrate reductase activity
U712_18780	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
U712_18785	COG1140	nitrate reductase beta subunit
U712_18790	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
U712_18795	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
U712_18805	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
U712_18810	COG2223	nitrite transmembrane transporter activity
U712_18815	COG0018	arginyl-trna synthetase
U712_18820	COG4506	Protein conserved in bacteria
U712_18830	COG0535	radical SAM domain protein
U712_18840	COG1131	(ABC) transporter
U712_18845	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
U712_18850	COG0612	Peptidase, M16
U712_18855	COG0612	Peptidase, M16
U712_18865	COG3391	amine dehydrogenase activity
U712_18870	COG3391	amine dehydrogenase activity
U712_18880	COG0457	Tetratricopeptide repeat
U712_18885	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
U712_18890	COG0010	Belongs to the arginase family
U712_18895	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
U712_18900	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
U712_18910	COG1994	Peptidase M50
U712_18915	COG1942	4-Oxalocrotonate Tautomerase
U712_18920	COG1846	Transcriptional regulator
U712_18925	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
U712_18935	COG0477	Major facilitator Superfamily
U712_18940	COG1959	2 iron, 2 sulfur cluster binding
U712_18945	COG3465	dGTPase activity
U712_18950	COG1078	dGTPase activity
U712_18955	COG4844	belongs to the
U712_18965	COG0697	spore germination
U712_18970	COG0095	Lipoate-protein ligase
U712_18975	COG0583	DNA-binding transcription factor activity
U712_18980	COG0280	phosphate acetyltransferase
U712_18990	COG1028	Short-chain dehydrogenase reductase Sdr
U712_18995	COG0436	Aminotransferase
U712_19000	COG2814	Major facilitator Superfamily
U712_19005	COG0151	Belongs to the GarS family
U712_19010	COG1028	Short-chain dehydrogenase reductase Sdr
U712_19015	COG1917	Cupin 2, conserved barrel domain protein
U712_19020	COG0077	Prephenate dehydratase
U712_19030	COG2814	Major facilitator Superfamily
U712_19035	COG0833	amino acid
U712_19040	COG4187	Peptidase family M20/M25/M40
U712_19045	COG1012	belongs to the aldehyde dehydrogenase family
U712_19050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
U712_19070	COG1088	dTDP-glucose 4,6-dehydratase activity
U712_19075	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
U712_19080	COG3980	spore coat polysaccharide biosynthesis protein
U712_19085	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
U712_19090	COG2089	acid synthase
U712_19095	COG0456	acetyltransferase
U712_19100	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
U712_19105	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
U712_19110	COG0463	Glycosyl transferase, family 2
U712_19125	COG2363	Small membrane protein
U712_19130	COG2233	PERMEase
U712_19145	COG1012	belongs to the aldehyde dehydrogenase family
U712_19150	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
U712_19155	COG1216	Glycosyl transferase, family 2
U712_19170	COG1695	Transcriptional regulator
U712_19175	COG0351	phosphomethylpyrimidine kinase
U712_19185	COG1621	beta-fructofuranosidase activity
U712_19190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U712_19190	COG1263	PTS System
U712_19195	COG2116	formate transmembrane transporter activity
U712_19200	COG3711	transcriptional antiterminator
U712_19210	COG1404	Belongs to the peptidase S8 family
U712_19215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
U712_19220	COG0778	Nitroreductase
U712_19230	COG0772	Belongs to the SEDS family
U712_19240	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
U712_19245	COG1845	cytochrome c oxidase, subunit III
U712_19250	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
U712_19255	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
U712_19260	COG2261	transglycosylase associated protein
U712_19265	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
U712_19270	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
U712_19275	COG2246	polysaccharide biosynthetic process
U712_19280	COG1309	transcriptional regulator
U712_19290	COG3162	membrane
U712_19300	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
U712_19305	COG2837	iron assimilation
U712_19310	COG2822	iron ion transport
U712_19315	COG0672	)-iron permease
U712_19320	COG0352	thiamine-phosphate diphosphorylase activity
U712_19325	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
U712_19330	COG0583	DNA-binding transcription factor activity
U712_19335	COG1380	Effector of murein hydrolase LrgA
U712_19340	COG1346	cytolysis
U712_19345	COG2814	Major facilitator Superfamily
U712_19350	COG4895	conserved protein (DUF2196)
U712_19355	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
U712_19360	COG0346	lactoylglutathione lyase activity
U712_19370	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
U712_19375	COG1404	Belongs to the peptidase S8 family
U712_19385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U712_19385	COG1263	PTS System
U712_19390	COG3711	transcriptional antiterminator
U712_19395	COG1442	glycosyl transferase family 8
U712_19400	COG5522	Integral membrane protein (intg_mem_TP0381)
U712_19405	COG1846	Transcriptional regulator
U712_19410	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
U712_19420	COG2234	aminopeptidase activity
U712_19425	COG2357	RelA SpoT domain protein
U712_19430	COG1575	Belongs to the MenA family. Type 1 subfamily
U712_19450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
U712_19455	COG1696	Membrane protein involved in D-alanine export
U712_19460	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
U712_19465	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
U712_19470	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
U712_19475	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
U712_19480	COG1486	melibiose metabolic process
U712_19485	COG1447	Phosphotransferase system cellobiose-specific component IIA
U712_19490	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
U712_19495	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
U712_19500	COG3711	transcriptional antiterminator
U712_19500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
U712_19510	COG2094	Belongs to the DNA glycosylase MPG family
U712_19515	COG0753	catalase activity
U712_19520	COG2814	Major facilitator Superfamily
U712_19525	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
U712_19530	COG1131	(ABC) transporter
U712_19550	COG1595	DNA-templated transcription, initiation
U712_19555	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
U712_19560	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
U712_19565	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
U712_19570	COG4988	ABC transporter
U712_19575	COG1294	oxidase, subunit
U712_19580	COG1271	oxidase subunit
U712_19585	COG3493	citrate carrier protein
U712_19590	COG0501	Belongs to the peptidase M48B family
U712_19600	COG0726	polysaccharide deacetylase
U712_19605	COG3842	ATPase activity
U712_19610	COG2508	Transcriptional regulator
U712_19615	COG1012	belongs to the aldehyde dehydrogenase family
U712_19620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
U712_19630	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
U712_19635	COG1881	PFAM PEBP family protein
U712_19640	COG0583	DNA-binding transcription factor activity
U712_19650	COG4585	Histidine kinase
U712_19655	COG2197	response regulator
U712_19660	COG2195	Cleaves the N-terminal amino acid of tripeptides
U712_19675	COG4894	glucomannan catabolic process
U712_19680	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
U712_19685	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
U712_19690	COG1028	Short-chain dehydrogenase reductase Sdr
U712_19695	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
U712_19700	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
U712_19705	COG2610	gluconate transmembrane transporter activity
U712_19715	COG0500	methyltransferase
U712_19725	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
U712_19740	COG0753	catalase activity
U712_19740	COG0693	protein deglycase activity
U712_19745	COG2851	Citrate transporter
U712_19750	COG2273	Hydrolase Family 16
U712_19755	COG3711	transcriptional antiterminator
U712_19775	COG2270	Major facilitator Superfamily
U712_19780	COG0513	Belongs to the DEAD box helicase family
U712_19785	COG3401	FG-GAP repeat protein
U712_19785	COG2755	lipolytic protein G-D-S-L family
U712_19840	COG3209	COG3209 Rhs family protein
U712_19845	COG0697	spore germination
U712_19850	COG0589	response to stress
U712_19855	COG2723	6-phospho-beta-galactosidase activity
U712_19860	COG2190	(PTS) system
U712_19860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
U712_19860	COG1263	PTS System
U712_19875	COG5444	nuclease activity
U712_19890	COG3507	Belongs to the glycosyl hydrolase 43 family
U712_19905	COG2986	histidine ammonia-lyase
U712_19910	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
U712_19915	COG1228	amidohydrolase
U712_19920	COG0010	Belongs to the arginase family
U712_19925	COG0833	amino acid
U712_19930	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
U712_19935	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
U712_19940	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
U712_19945	COG2390	Transcriptional regulator
U712_19955	COG3192	ethanolamine utilization protein
U712_19960	COG2079	MmgE PrpD family protein
U712_19970	COG1126	abc transporter atp-binding protein
U712_19975	COG0765	amino acid transport
U712_19980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
U712_20000	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
U712_20005	COG0561	phosphatase activity
U712_20035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
U712_20040	COG5294	Protein conserved in bacteria
U712_20045	COG0577	efflux transmembrane transporter activity
U712_20050	COG1136	(ABC) transporter
U712_20055	COG2205	protein histidine kinase activity
U712_20060	COG0745	RESPONSE REGULATOR receiver
U712_20065	COG0191	fructose-bisphosphate aldolase activity
U712_20070	COG1082	Xylose isomerase domain protein TIM barrel
U712_20075	COG1082	Xylose isomerase domain protein TIM barrel
U712_20080	COG0673	inositol 2-dehydrogenase activity
U712_20085	COG2814	Major facilitator Superfamily
U712_20090	COG1082	Xylose isomerase domain protein TIM barrel
U712_20095	COG3962	Belongs to the TPP enzyme family
U712_20100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
U712_20105	COG3718	enzyme involved in inositol metabolism
U712_20110	COG1012	belongs to the aldehyde dehydrogenase family
U712_20115	COG1349	DNA-binding transcription factor activity
U712_20120	COG0667	Aldo Keto reductase
U712_20140	COG2814	Major facilitator Superfamily
U712_20145	COG0326	Molecular chaperone. Has ATPase activity
U712_20155	COG1028	Short-chain dehydrogenase reductase Sdr
U712_20160	COG1309	transcriptional regulator
U712_20165	COG1012	belongs to the aldehyde dehydrogenase family
U712_20170	COG0456	acetyltransferase
U712_20175	COG2850	peptidyl-arginine hydroxylation
U712_20180	COG2226	methyltransferase
U712_20195	COG0367	asparagine synthase
U712_20200	COG2814	Major facilitator Superfamily
U712_20205	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
U712_20215	COG1714	RDD family
U712_20220	COG2311	Membrane
U712_20225	COG1917	Cupin 2, conserved barrel domain protein
U712_20230	COG1309	transcriptional regulator
U712_20235	COG1028	Short-chain dehydrogenase reductase Sdr
U712_20240	COG1846	Transcriptional regulator
U712_20245	COG1380	Effector of murein hydrolase LrgA
U712_20250	COG1346	cytolysis
U712_20255	COG5039	Polysaccharide pyruvyl transferase
U712_20260	COG1929	Belongs to the glycerate kinase type-1 family
U712_20265	COG1802	Transcriptional regulator
U712_20270	COG1070	Carbohydrate kinase
U712_20275	COG2610	gluconate transmembrane transporter activity
U712_20280	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
U712_20285	COG0450	alkyl hydroperoxide reductase
U712_20290	COG3634	alkyl hydroperoxide reductase activity
U712_20295	COG2723	6-phospho-beta-galactosidase activity
U712_20300	COG2190	(PTS) system
U712_20305	COG2188	Transcriptional regulator
U712_20320	COG1131	(ABC) transporter
U712_20325	COG1994	Peptidase M50
U712_20330	COG0535	radical SAM domain protein
U712_20340	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
U712_20345	COG5293	efflux transmembrane transporter activity
U712_20355	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
U712_20360	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
U712_20375	COG1063	alcohol dehydrogenase
U712_20395	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
U712_20400	COG0456	acetyltransferase
U712_20405	COG0457	Tetratricopeptide repeat
U712_20415	COG0010	Belongs to the arginase family
U712_20420	COG0833	amino acid
U712_20425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
U712_20430	COG3829	transcription factor binding
U712_20435	COG5002	protein histidine kinase activity
U712_20450	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
U712_20455	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
U712_20460	COG4853	Protein conserved in bacteria
U712_20465	COG4863	YycH protein
U712_20470	COG5002	protein histidine kinase activity
U712_20475	COG0745	RESPONSE REGULATOR receiver
U712_20485	COG0346	lactoylglutathione lyase activity
U712_20490	COG0305	Participates in initiation and elongation during chromosome replication
U712_20505	COG3093	addiction module antidote protein HigA
U712_20510	COG2807	transmembrane transport
U712_20515	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
U712_20520	COG0359	binds to the 23S rRNA
U712_20525	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
U712_20530	COG4241	membrane
U712_20545	COG5577	PFAM Coat F domain
U712_20550	COG1733	regulation of RNA biosynthetic process
U712_20555	COG1227	inorganic diphosphatase activity
U712_20570	COG2271	Major facilitator Superfamily
U712_20580	COG4319	ketosteroid isomerase
U712_20585	COG2271	Major facilitator Superfamily
U712_20620	COG1131	(ABC) transporter
U712_20630	COG4319	ketosteroid isomerase
U712_20635	COG1357	PFAM Pentapeptide repeats (8 copies)
U712_20640	COG2814	Major facilitator Superfamily
U712_20645	COG0583	DNA-binding transcription factor activity
U712_20650	COG2153	protein acetylation
U712_20660	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
U712_20665	COG1846	Transcriptional regulator
U712_20670	COG2153	protein acetylation
U712_20675	COG2364	Membrane
U712_20680	COG0456	acetyltransferase
U712_20685	COG2315	Protein conserved in bacteria
U712_20690	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
U712_20695	COG2814	Major facilitator Superfamily
U712_20700	COG1331	Highly conserved protein containing a thioredoxin domain
U712_20705	COG0789	Transcriptional regulator
U712_20710	COG0697	spore germination
U712_20715	COG1331	Highly conserved protein containing a thioredoxin domain
U712_20720	COG1266	CAAX protease self-immunity
U712_20725	COG0477	Major facilitator Superfamily
U712_20725	COG2814	Major facilitator Superfamily
U712_20730	COG0110	maltose O-acetyltransferase activity
U712_20735	COG0346	lactoylglutathione lyase activity
U712_20740	COG1609	Transcriptional regulator
U712_20745	COG0708	Exodeoxyribonuclease III
U712_20750	COG0629	single-stranded DNA binding
U712_20755	COG0360	Binds together with S18 to 16S ribosomal RNA
U712_20760	COG0012	GTP binding
U712_20765	COG0243	molybdopterin cofactor binding
U712_20770	COG4481	Protein conserved in bacteria
U712_20775	COG3949	Membrane
U712_20785	COG1475	DNA binding
U712_20790	COG1192	Involved in chromosome partitioning
U712_20800	COG1475	DNA binding
U712_20805	COG0357	Ribosomal RNA small subunit methyltransferase G
U712_20810	COG0445	tRNA wobble uridine modification
U712_20815	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
U712_20820	COG1847	R3H domain protein
U712_20825	COG0706	membrane insertase activity
U712_20830	COG0594	ribonuclease P activity