locus-tag	class	description
B657_00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
B657_00020	COG0592	DNA-directed DNA polymerase activity
B657_00030	COG2501	S4 domain
B657_00040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
B657_00060	COG0187	DNA topoisomerase II activity
B657_00070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B657_00090	COG0517	IMP dehydrogenase activity
B657_00090	COG0516	GMP reductase activity
B657_00100	COG1686	Belongs to the peptidase S11 family
B657_00110	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
B657_00120	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
B657_00130	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
B657_00140	COG1428	Deoxynucleoside kinase
B657_00150	COG1428	Deoxynucleoside kinase
B657_00160	COG1388	LysM domain
B657_00160	COG3858	chitin binding
B657_00170	COG1335	isochorismatase
B657_00180	COG0590	tRNA wobble adenosine to inosine editing
B657_00190	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
B657_00200	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
B657_00210	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
B657_00250	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
B657_00260	COG3853	Toxic anion resistance protein (TelA)
B657_00270	COG1982	Orn Lys Arg decarboxylase major
B657_00280	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B657_00290	COG3870	Protein conserved in bacteria
B657_00300	COG1728	Protein conserved in bacteria
B657_00310	COG0470	DNA polymerase III
B657_00320	COG1774	PSP1 C-terminal conserved region
B657_00330	COG4467	Involved in initiation control of chromosome replication
B657_00340	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
B657_00350	COG2827	Endonuclease containing a URI domain
B657_00360	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
B657_00370	COG2002	toxin-antitoxin pair type II binding
B657_00380	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B657_00380	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B657_00390	COG0084	hydrolase, TatD family'
B657_00400	COG3583	domain protein
B657_00400	COG3584	3D domain protein
B657_00410	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B657_00420	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
B657_00440	COG4466	Protein conserved in bacteria
B657_00460	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
B657_00470	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B657_00480	COG0251	oxidation-reduction process
B657_00490	COG2088	sporulation resulting in formation of a cellular spore
B657_00500	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
B657_00510	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
B657_00520	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
B657_00530	COG0193	aminoacyl-tRNA hydrolase activity
B657_00550	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
B657_00560	COG2002	toxin-antitoxin pair type II binding
B657_00570	COG2244	polysaccharide biosynthetic process
B657_00580	COG3956	TIGRFAM MazG family protein
B657_00590	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
B657_00620	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
B657_00630	COG1098	S1 RNA binding domain
B657_00640	COG2208	phosphoserine phosphatase activity
B657_00650	COG2304	oxidoreductase activity
B657_00660	COG0515	serine threonine protein kinase
B657_00670	COG0037	tRNA processing
B657_00690	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B657_00700	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
B657_00710	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
B657_00720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B657_00730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B657_00740	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B657_00750	COG0512	Glutamine amidotransferase of anthranilate synthase
B657_00760	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B657_00770	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
B657_00780	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
B657_00790	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
B657_00800	COG1396	sequence-specific DNA binding
B657_00810	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B657_00820	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
B657_00830	COG4463	regulation of RNA biosynthetic process
B657_00840	COG3880	PFAM UvrB UvrC protein
B657_00850	COG3869	Catalyzes the specific phosphorylation of arginine residues in
B657_00860	COG0542	response to heat
B657_00870	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
B657_00880	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
B657_00890	COG4956	integral membrane protein (PIN domain superfamily)
B657_00900	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
B657_00910	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
B657_00920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
B657_00930	COG1045	serine acetyltransferase
B657_00940	COG0215	cysteine-tRNA ligase activity
B657_00950	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
B657_00960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B657_00970	COG3688	RNA-binding protein containing a PIN domain
B657_00980	COG1595	DNA-templated transcription, initiation
B657_00990	COG0267	Belongs to the bacterial ribosomal protein bL33 family
B657_01000	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B657_01020	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
B657_01030	COG0081	regulation of translation
B657_01040	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
B657_01050	COG0222	ribosome binding
B657_01060	COG2813	Specifically methylates the guanine in position
B657_01070	COG0085	RNA polymerase activity
B657_01080	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
B657_01090	COG1358	cellular component organization or biogenesis
B657_01100	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
B657_01110	COG0049	tRNA binding
B657_01120	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
B657_01130	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
B657_01140	COG0596	Alpha beta hydrolase
B657_01150	COG0051	transcription antitermination factor activity, RNA binding
B657_01160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
B657_01170	COG0088	Forms part of the polypeptide exit tunnel
B657_01180	COG0089	rRNA binding
B657_01190	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
B657_01200	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
B657_01210	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
B657_01220	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
B657_01230	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
B657_01240	COG0255	Belongs to the universal ribosomal protein uL29 family
B657_01250	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
B657_01260	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
B657_01280	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
B657_01300	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
B657_01310	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
B657_01320	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
B657_01330	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
B657_01340	COG1841	ribosomal large subunit assembly
B657_01350	COG0200	Binds to the 23S rRNA
B657_01360	COG0201	protein transport
B657_01370	COG0563	adenylate kinase activity
B657_01380	COG0024	Methionine aminopeptidase
B657_01389	COG2163	COG2163 Ribosomal protein L14E L6E L27E
B657_01390	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
B657_01400	COG0257	Belongs to the bacterial ribosomal protein bL36 family
B657_01410	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
B657_01420	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
B657_01430	COG0202	RNA polymerase activity
B657_01440	COG0203	ribosomal protein L17
B657_01450	COG1122	ATPase activity
B657_01460	COG1122	ATPase activity
B657_01470	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B657_01480	COG0101	tRNA pseudouridine synthase activity
B657_01490	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
B657_01500	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
B657_01510	COG2226	methyltransferase
B657_01530	COG0860	N-Acetylmuramoyl-L-alanine amidase
B657_01540	COG0489	protein tyrosine kinase activity
B657_01560	COG2194	sulfuric ester hydrolase activity
B657_01570	COG0726	polysaccharide deacetylase
B657_01580	COG0659	secondary active sulfate transmembrane transporter activity
B657_01590	COG0385	Bile acid
B657_01600	COG2819	hydrolase of the alpha beta superfamily
B657_01610	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B657_01620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B657_01630	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B657_01640	COG2207	Transcriptional regulator
B657_01640	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B657_01650	COG3876	Protein conserved in bacteria
B657_01660	COG1472	Belongs to the glycosyl hydrolase 3 family
B657_01670	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B657_01680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B657_01680	COG1263	PTS System
B657_01690	COG1737	Transcriptional regulator
B657_01700	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
B657_01710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B657_01720	COG1683	Conserved Protein
B657_01730	COG1595	DNA-templated transcription, initiation
B657_01740	COG5662	AntiSigma factor
B657_01750	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B657_01760	COG4856	YbbR-like protein
B657_01770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B657_01780	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B657_01800	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B657_01810	COG2169	Transcriptional regulator
B657_01820	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B657_01830	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B657_01845	COG3002	Belongs to the UPF0753 family
B657_01860	COG0288	reversible hydration of carbon dioxide
B657_01880	COG5609	conserved protein (DUF2294)
B657_01889	COG0640	Transcriptional regulator
B657_01890	COG2814	Major facilitator Superfamily
B657_01900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B657_01920	COG0535	radical SAM domain protein
B657_01935	COG1266	CAAX protease self-immunity
B657_01950	COG1131	(ABC) transporter
B657_01970	COG1413	lyase activity
B657_01980	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B657_01990	COG0596	Alpha beta hydrolase
B657_02000	COG0745	RESPONSE REGULATOR receiver
B657_02030	COG0515	serine threonine protein kinase
B657_02060	COG1113	amino acid transport
B657_02090	COG2602	Beta-lactamase
B657_02100	COG2124	cytochrome p450
B657_02120	COG0531	amino acid
B657_02130	COG0584	glycerophosphoryl diester phosphodiesterase
B657_02140	COG2271	Major facilitator Superfamily
B657_02160	COG1846	Transcriptional regulator
B657_02160	COG0456	acetyltransferase
B657_02170	COG2271	Major facilitator Superfamily
B657_02200	COG3409	Peptidoglycan-binding domain 1 protein
B657_02210	COG0697	spore germination
B657_02220	COG2207	Transcriptional regulator
B657_02220	COG1917	Cupin 2, conserved barrel domain protein
B657_02230	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
B657_02240	COG3591	Belongs to the peptidase S1B family
B657_02260	COG0596	Alpha beta hydrolase
B657_02270	COG1183	phosphatidylcholine synthase activity
B657_02280	COG0586	Pfam SNARE associated Golgi protein
B657_02290	COG0688	phosphatidylethanolamine metabolic process
B657_02310	COG2312	Erythromycin esterase
B657_02320	COG2207	Transcriptional regulator
B657_02340	COG1301	dicarboxylic acid transport
B657_02350	COG1263	PTS System
B657_02350	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B657_02350	COG2190	(PTS) system
B657_02360	COG0363	glucosamine-6-phosphate deaminase activity
B657_02390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B657_02400	COG0833	amino acid
B657_02410	COG2040	homocysteine
B657_02420	COG1115	amino acid carrier protein
B657_02430	COG2066	Belongs to the glutaminase family
B657_02440	COG4191	Histidine kinase
B657_02450	COG0784	Response regulator, receiver
B657_02460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B657_02470	COG1012	belongs to the aldehyde dehydrogenase family
B657_02480	COG2271	Major facilitator Superfamily
B657_02490	COG4948	Mandelate Racemase Muconate Lactonizing
B657_02500	COG2186	Transcriptional regulator
B657_02510	COG2721	sulfolactate sulfo-lyase activity
B657_02520	COG3173	Aminoglycoside phosphotransferase
B657_02540	COG0697	spore germination
B657_02550	COG0745	RESPONSE REGULATOR receiver
B657_02560	COG2205	protein histidine kinase activity
B657_02570	COG1131	(ABC) transporter
B657_02600	COG3773	Cell wall hydrolase
B657_02610	COG2304	oxidoreductase activity
B657_02620	COG3540	Alkaline phosphatase
B657_02630	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B657_02640	COG0805	protein transport
B657_02650	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
B657_02660	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B657_02670	COG0477	Major facilitator Superfamily
B657_02680	COG1309	transcriptional regulator
B657_02690	COG0252	asparaginase activity
B657_02700	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B657_02710	COG1714	RDD family
B657_02720	COG3012	SEC-C Motif Domain Protein
B657_02720	COG1405	negative regulation of cell septum assembly
B657_02730	COG3290	protein histidine kinase activity
B657_02740	COG3279	Response regulator of the LytR AlgR family
B657_02750	COG4555	ABC transporter
B657_02760	COG1668	transmembrane transport
B657_02770	COG0667	Aldo Keto reductase
B657_02790	COG1595	DNA-templated transcription, initiation
B657_02800	COG1595	DNA-templated transcription, initiation
B657_02810	COG1876	peptidase activity
B657_02820	COG0457	Tetratricopeptide repeat
B657_02830	COG1028	Short-chain dehydrogenase reductase Sdr
B657_02840	COG0366	Alpha amylase catalytic
B657_02850	COG0803	Belongs to the bacterial solute-binding protein 9 family
B657_02860	COG1121	(ABC) transporter
B657_02870	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B657_02880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B657_02890	COG2310	stress, protein
B657_02900	COG2310	stress, protein
B657_02910	COG2310	stress, protein
B657_02920	COG0861	Integral membrane protein TerC family
B657_02940	COG3853	Toxic anion resistance protein (TelA)
B657_02950	COG0477	Major facilitator Superfamily
B657_02960	COG2814	Major facilitator Superfamily
B657_02970	COG0640	Transcriptional regulator
B657_02980	COG0517	IMP dehydrogenase activity
B657_02980	COG4175	Glycine betaine
B657_02990	COG4176	ABC-type proline glycine betaine transport system permease component
B657_03000	COG2113	Glycine betaine
B657_03010	COG1473	amidohydrolase
B657_03020	COG1288	antiporter activity
B657_03040	COG0366	Alpha amylase catalytic
B657_03050	COG0039	L-malate dehydrogenase activity
B657_03060	COG1620	l-lactate permease
B657_03070	COG2814	Major facilitator Superfamily
B657_03080	COG1846	Transcriptional regulator
B657_03090	COG1280	lysine exporter protein (LysE YggA)
B657_03100	COG3403	YqcI/YcgG family
B657_03110	COG1113	amino acid transport
B657_03120	COG3665	Urea carboxylase-associated protein
B657_03130	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
B657_03140	COG1660	Displays ATPase and GTPase activities
B657_03160	COG2226	methyltransferase
B657_03170	COG0583	DNA-binding transcription factor activity
B657_03180	COG3458	cephalosporin-C deacetylase activity
B657_03190	COG3541	Predicted nucleotidyltransferase
B657_03200	COG0506	proline dehydrogenase activity
B657_03210	COG1012	belongs to the aldehyde dehydrogenase family
B657_03220	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B657_03230	COG2508	Transcriptional regulator
B657_03240	COG3689	TIGRFAM TIGR03943 family protein
B657_03250	COG0701	Predicted permease
B657_03260	COG2267	carboxylic ester hydrolase activity
B657_03270	COG0492	ferredoxin-NADP+ reductase activity
B657_03280	COG1587	Uroporphyrinogen-III synthase
B657_03280	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B657_03290	COG2146	nitrite reductase [NAD(P)H] activity
B657_03300	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B657_03310	COG0243	molybdopterin cofactor binding
B657_03320	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B657_03330	COG2223	nitrite transmembrane transporter activity
B657_03340	COG1469	GTP cyclohydrolase I activity
B657_03350	COG1376	ErfK ybiS ycfS ynhG family protein
B657_03360	COG0523	cobalamin synthesis protein
B657_03370	COG0765	amino acid transport
B657_03380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B657_03390	COG1714	RDD family
B657_03410	COG2723	6-phospho-beta-galactosidase activity
B657_03430	COG3209	COG3209 Rhs family protein
B657_03440	COG3290	protein histidine kinase activity
B657_03440	COG0840	transmembrane signaling receptor activity
B657_03450	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
B657_03460	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
B657_03470	COG1733	regulation of RNA biosynthetic process
B657_03480	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B657_03490	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B657_03510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B657_03520	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
B657_03530	COG2814	Major facilitator Superfamily
B657_03550	COG0697	spore germination
B657_03560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B657_03580	COG2364	Membrane
B657_03590	COG1126	abc transporter atp-binding protein
B657_03600	COG0765	amino acid transport
B657_03610	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B657_03620	COG0583	DNA-binding transcription factor activity
B657_03630	COG0163	prenyltransferase activity
B657_03640	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
B657_03660	COG0596	Alpha beta hydrolase
B657_03670	COG3104	oligopeptide transport
B657_03680	COG5434	Belongs to the glycosyl hydrolase 28 family
B657_03700	COG0697	spore germination
B657_03720	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B657_03730	COG1136	(ABC) transporter
B657_03740	COG0577	efflux transmembrane transporter activity
B657_03750	COG0745	RESPONSE REGULATOR receiver
B657_03760	COG3850	Histidine kinase
B657_03760	COG5002	protein histidine kinase activity
B657_03770	COG0457	Tetratricopeptide repeat
B657_03790	COG0527	aspartate kinase activity
B657_03800	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B657_03810	COG4605	iron ion homeostasis
B657_03820	COG4604	ABC transporter, ATP-binding protein
B657_03830	COG4607	ABC-type enterochelin transport system periplasmic component
B657_03840	COG2814	Major facilitator Superfamily
B657_03850	COG1309	transcriptional regulator
B657_03860	COG0778	Nitroreductase
B657_03870	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
B657_03880	COG0640	Transcriptional regulator
B657_03890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B657_03900	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
B657_03910	COG1012	belongs to the aldehyde dehydrogenase family
B657_03920	COG4975	Glucose uptake
B657_03930	COG1028	Short-chain dehydrogenase reductase Sdr
B657_03940	COG4549	nuclear export factor GLE1
B657_03950	COG1276	copper resistance
B657_03950	COG2372	response to copper ion
B657_03960	COG1349	DNA-binding transcription factor activity
B657_03981	COG2213	PTS system mannitol-specific
B657_03982	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
B657_03990	COG0246	Mannitol dehydrogenase
B657_04000	COG0473	3-isopropylmalate dehydrogenase activity
B657_04010	COG0681	Belongs to the peptidase S26 family
B657_04020	COG0412	Dienelactone hydrolase
B657_04030	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B657_04040	COG0561	phosphatase activity
B657_04050	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
B657_04060	COG1914	H( )-stimulated, divalent metal cation uptake system
B657_04070	COG4336	lyase activity
B657_04080	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
B657_04090	COG1984	allophanate hydrolase subunit 2
B657_04100	COG1414	Transcriptional regulator
B657_04110	COG2755	lipolytic protein G-D-S-L family
B657_04130	COG2329	Antibiotic biosynthesis monooxygenase
B657_04140	COG0768	penicillin binding
B657_04150	COG4989	oxidoreductase activity
B657_04160	COG3711	transcriptional antiterminator
B657_04170	COG0318	PFAM AMP-dependent synthetase and ligase
B657_04180	COG2226	methyltransferase
B657_04190	COG1028	Short-chain dehydrogenase reductase Sdr
B657_04200	COG1917	Cupin 2, conserved barrel domain protein
B657_04210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B657_04220	COG3871	stress protein (general stress protein 26)
B657_04240	COG2814	Major facilitator Superfamily
B657_04250	COG1522	sequence-specific DNA binding
B657_04260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B657_04260	COG0551	DNA topoisomerase type I activity
B657_04270	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
B657_04280	COG3706	GGDEF domain
B657_04290	COG5298	Protein conserved in bacteria
B657_04300	COG1215	transferase activity, transferring glycosyl groups
B657_04320	COG0531	amino acid
B657_04330	COG0494	nUDIX hydrolase
B657_04340	COG0028	Belongs to the TPP enzyme family
B657_04360	COG1914	H( )-stimulated, divalent metal cation uptake system
B657_04380	COG4876	unkown
B657_04390	COG2217	Heavy metal translocating P-type atpase
B657_04400	COG3729	General stress protein
B657_04410	COG0662	Cupin 2, conserved barrel domain protein
B657_04420	COG2329	Antibiotic biosynthesis monooxygenase
B657_04430	COG3546	catalase activity
B657_04440	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
B657_04450	COG3290	protein histidine kinase activity
B657_04460	COG4565	transcriptional regulatory protein
B657_04470	COG1301	dicarboxylic acid transport
B657_04490	COG1131	(ABC) transporter
B657_04500	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B657_04520	COG1960	acyl-CoA dehydrogenase activity
B657_04540	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B657_04550	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B657_04560	COG1181	Belongs to the D-alanine--D-alanine ligase family
B657_04570	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
B657_04580	COG0513	Belongs to the DEAD box helicase family
B657_04590	COG3402	PFAM membrane-flanked domain
B657_04600	COG3428	Bacterial PH domain
B657_04610	COG0705	Rhomboid family
B657_04620	COG0736	holo-[acyl-carrier-protein] synthase activity
B657_04630	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
B657_04650	COG0864	Transcriptional regulator
B657_04660	COG2337	Toxic component of a toxin-antitoxin (TA) module
B657_04670	COG1366	Belongs to the anti-sigma-factor antagonist family
B657_04680	COG1366	Belongs to the anti-sigma-factor antagonist family
B657_04690	COG2172	sigma factor antagonist activity
B657_04700	COG2208	phosphoserine phosphatase activity
B657_04710	COG1366	Belongs to the anti-sigma-factor antagonist family
B657_04720	COG2172	sigma factor antagonist activity
B657_04730	COG1191	sigma factor activity
B657_04740	COG2208	phosphoserine phosphatase activity
B657_04760	COG1673	EVE domain
B657_04770	COG1846	Transcriptional regulator
B657_04780	COG2183	response to ionizing radiation
B657_04790	COG3091	SprT-like family
B657_05040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B657_05050	COG1522	sequence-specific DNA binding
B657_05060	COG1522	sequence-specific DNA binding
B657_05070	COG1335	isochorismatase
B657_05080	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B657_05090	COG2814	Major facilitator Superfamily
B657_05110	COG0693	protein deglycase activity
B657_05120	COG1278	Cold shock
B657_05130	COG1329	Transcriptional regulator
B657_05140	COG0697	spore germination
B657_05150	COG2207	Transcriptional regulator
B657_05150	COG1917	Cupin 2, conserved barrel domain protein
B657_05160	COG0697	spore germination
B657_05170	COG2207	Transcriptional regulator
B657_05170	COG3708	Transcriptional regulator
B657_05180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B657_05190	COG0477	Major facilitator Superfamily
B657_05210	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
B657_05230	COG0697	spore germination
B657_05240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B657_05250	COG2030	dehydratase
B657_05260	COG3545	Serine hydrolase
B657_05270	COG1733	regulation of RNA biosynthetic process
B657_05280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B657_05290	COG1733	regulation of RNA biosynthetic process
B657_05300	COG2249	NAD(P)H dehydrogenase (quinone) activity
B657_05310	COG2814	Major facilitator Superfamily
B657_05320	COG1309	transcriptional regulator
B657_05330	COG0640	Transcriptional regulator
B657_05340	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B657_05350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B657_05360	COG0697	spore germination
B657_05370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B657_05380	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B657_05390	COG0640	Transcriptional regulator
B657_05400	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B657_05410	COG4585	Histidine kinase
B657_05420	COG2197	response regulator
B657_05430	COG2409	Drug exporters of the RND superfamily
B657_05440	COG0596	Alpha beta hydrolase
B657_05450	COG1811	Na channel or pump
B657_05460	COG4978	Transcriptional regulator
B657_05460	COG0789	Transcriptional regulator
B657_05470	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B657_05480	COG0778	Nitroreductase
B657_05490	COG0346	lactoylglutathione lyase activity
B657_05500	COG2259	Doxx family
B657_05510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B657_05530	COG2323	membrane
B657_05540	COG2323	membrane
B657_05550	COG0071	Belongs to the small heat shock protein (HSP20) family
B657_05580	COG1309	transcriptional regulator
B657_05600	COG0456	acetyltransferase
B657_05620	COG1113	amino acid transport
B657_05630	COG2318	DinB family
B657_05640	COG1846	Transcriptional regulator
B657_05650	COG2409	Drug exporters of the RND superfamily
B657_05650	COG1033	growth of symbiont in host cell
B657_05660	COG0778	Nitroreductase
B657_05670	COG1846	Transcriptional regulator
B657_05680	COG2814	Major facilitator Superfamily
B657_05690	COG0730	response to heat
B657_05700	COG1802	Transcriptional regulator
B657_05710	COG3858	chitin binding
B657_05710	COG1388	LysM domain
B657_05720	COG1819	glycosyl
B657_05740	COG1785	Belongs to the alkaline phosphatase family
B657_05750	COG5646	InterPro IPR014922
B657_05770	COG0454	-acetyltransferase
B657_05780	COG1078	dGTPase activity
B657_05790	COG1388	LysM domain
B657_05800	COG2814	Major facilitator Superfamily
B657_05810	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B657_05820	COG1447	Phosphotransferase system cellobiose-specific component IIA
B657_05830	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B657_05840	COG2723	6-phospho-beta-galactosidase activity
B657_05850	COG2188	Transcriptional regulator
B657_05860	COG1940	carbohydrate kinase activity
B657_05870	COG1482	cell wall glycoprotein biosynthetic process
B657_05880	COG4124	Belongs to the glycosyl hydrolase 26 family
B657_05900	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
B657_05910	COG0802	atpase or kinase
B657_05920	COG1214	PFAM Peptidase M22, glycoprotease
B657_05930	COG0456	acetyltransferase
B657_05940	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
B657_05950	COG0488	(ABC) transporter
B657_05960	COG0315	cyclic pyranopterin monophosphate synthase activity
B657_05970	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
B657_05980	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B657_05990	COG0805	protein transport
B657_06010	COG1266	CAAX protease self-immunity
B657_06020	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
B657_06030	COG0459	protein refolding
B657_06040	COG3378	Phage plasmid primase P4 family
B657_06060	COG0270	DNA (cytosine-5-)-methyltransferase activity
B657_06070	COG0270	DNA (cytosine-5-)-methyltransferase activity
B657_06100	COG1401	restriction endodeoxyribonuclease activity
B657_06130	COG1073	alpha beta
B657_06140	COG0457	Tetratricopeptide repeat
B657_06150	COG1063	alcohol dehydrogenase
B657_06160	COG2211	Major facilitator Superfamily
B657_06170	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B657_06180	COG1842	Phage shock protein A
B657_06190	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B657_06200	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
B657_06210	COG4260	virion core protein, lumpy skin disease virus
B657_06230	COG2814	Major facilitator Superfamily
B657_06240	COG1063	alcohol dehydrogenase
B657_06250	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
B657_06260	COG0823	Involved in the tonB-independent uptake of proteins
B657_06280	COG2267	carboxylic ester hydrolase activity
B657_06300	COG2132	Multicopper oxidase
B657_06310	COG1113	amino acid transport
B657_06320	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
B657_06330	COG0714	Associated with various cellular activities
B657_06340	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
B657_06350	COG1305	Transglutaminase-like
B657_06360	COG0519	Catalyzes the synthesis of GMP from XMP
B657_06360	COG0518	GMP synthase (glutamine-hydrolyzing) activity
B657_06370	COG2252	PERMEase
B657_06380	COG3064	Membrane
B657_06400	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
B657_06420	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
B657_06430	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
B657_06440	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
B657_06450	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
B657_06460	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B657_06470	COG0047	phosphoribosylformylglycinamidine synthase activity
B657_06480	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
B657_06490	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
B657_06500	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
B657_06510	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
B657_06520	COG0138	bifunctional purine biosynthesis protein purh
B657_06530	COG0151	Belongs to the GarS family
B657_06540	COG1522	sequence-specific DNA binding
B657_06550	COG0531	amino acid
B657_06560	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B657_06570	COG1470	cell adhesion involved in biofilm formation
B657_06580	COG4496	protein, YerC YecD
B657_06590	COG0069	glutamate synthase activity
B657_06600	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
B657_06610	COG0210	DNA helicase
B657_06620	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
B657_06630	COG4851	CamS sex pheromone cAM373 precursor
B657_06640	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B657_06650	COG1285	pathogenesis
B657_06660	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B657_06670	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B657_06680	COG0154	amidase activity
B657_06690	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
B657_06700	COG1309	transcriptional regulator
B657_06710	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
B657_06720	COG1597	lipid kinase activity
B657_06730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B657_06740	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B657_06750	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B657_06760	COG1002	Type II restriction enzyme, methylase subunits
B657_06770	COG1061	Type III restriction enzyme res subunit
B657_06780	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B657_06812	COG5444	nuclease activity
B657_06820	COG3391	amine dehydrogenase activity
B657_06830	COG0457	Tetratricopeptide repeat
B657_06840	COG0217	transcriptional regulatory protein
B657_06860	COG1309	transcriptional regulator
B657_06870	COG3631	Ketosteroid isomerase-related protein
B657_06880	COG0702	epimerase
B657_06910	COG3546	catalase activity
B657_06920	COG0454	-acetyltransferase
B657_06940	COG5578	integral membrane protein
B657_06950	COG2972	Histidine kinase
B657_06960	COG4753	response regulator
B657_06960	COG2207	Transcriptional regulator
B657_06970	COG1653	transport
B657_06980	COG1175	transmembrane transport
B657_06990	COG0395	ABC-type sugar transport system, permease component
B657_07000	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
B657_07010	COG2207	Transcriptional regulator
B657_07020	COG2755	lipolytic protein G-D-S-L family
B657_07040	COG5578	integral membrane protein
B657_07050	COG3401	FG-GAP repeat protein
B657_07060	COG3401	FG-GAP repeat protein
B657_07070	COG2755	lipolytic protein G-D-S-L family
B657_07080	COG1874	Beta-galactosidase
B657_07100	COG1653	transport
B657_07110	COG4209	transmembrane transport
B657_07120	COG0395	ABC-type sugar transport system, permease component
B657_07130	COG1486	melibiose metabolic process
B657_07140	COG2323	membrane
B657_07150	COG2329	Antibiotic biosynthesis monooxygenase
B657_07160	COG0346	lactoylglutathione lyase activity
B657_07190	COG5583	Uncharacterized small protein (DUF2292)
B657_07200	COG0670	Belongs to the BI1 family
B657_07210	COG0697	spore germination
B657_07220	COG1846	Transcriptional regulator
B657_07230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B657_07250	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B657_07250	COG2124	cytochrome p450
B657_07260	COG1368	sulfuric ester hydrolase activity
B657_07270	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
B657_07280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B657_07290	COG1442	glycosyl transferase family 8
B657_07300	COG1216	Glycosyl transferase, family 2
B657_07310	COG1442	glycosyl transferase family 8
B657_07320	COG2223	nitrite transmembrane transporter activity
B657_07330	COG1011	Hydrolase
B657_07340	COG0531	amino acid
B657_07350	COG1012	belongs to the aldehyde dehydrogenase family
B657_07360	COG0840	transmembrane signaling receptor activity
B657_07370	COG0488	(ABC) transporter
B657_07390	COG0789	Transcriptional regulator
B657_07400	COG2814	Major facilitator Superfamily
B657_07420	COG0488	(ABC) transporter
B657_07430	COG0513	Belongs to the DEAD box helicase family
B657_07440	COG0456	acetyltransferase
B657_07450	COG2130	NADP-dependent
B657_07460	COG2211	Major facilitator Superfamily
B657_07480	COG1262	PFAM Formylglycine-generating sulfatase enzyme
B657_07490	COG1120	ATPase activity
B657_07500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B657_07510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B657_07520	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B657_07560	COG3866	Pectate lyase
B657_07570	COG0471	metal ion transport
B657_07580	COG3290	protein histidine kinase activity
B657_07590	COG4565	transcriptional regulatory protein
B657_07600	COG3181	Tripartite tricarboxylate transporter family receptor
B657_07610	COG2851	Citrate transporter
B657_07620	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B657_07630	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
B657_07640	COG1254	Belongs to the acylphosphatase family
B657_07650	COG2258	MOSC domain
B657_07690	COG0024	Methionine aminopeptidase
B657_07700	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B657_07700	COG1263	PTS System
B657_07710	COG1368	sulfuric ester hydrolase activity
B657_07750	COG1115	amino acid carrier protein
B657_07760	COG0531	amino acid
B657_07790	COG0697	spore germination
B657_07800	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B657_07800	COG1263	PTS System
B657_07810	COG0366	Alpha amylase catalytic
B657_07820	COG2188	Transcriptional regulator
B657_07830	COG0778	Nitroreductase
B657_07840	COG0737	Belongs to the 5'-nucleotidase family
B657_07850	COG0693	protein deglycase activity
B657_07860	COG2814	Major facilitator Superfamily
B657_07870	COG4840	Belongs to the UPF0435 family
B657_07880	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B657_07890	COG4980	gas vesicle protein
B657_07900	COG1295	ribonuclease BN
B657_07910	COG0477	Major facilitator Superfamily
B657_07920	COG0387	Pfam Sodium calcium exchanger
B657_07940	COG0668	transmembrane transport
B657_07955	COG0535	radical SAM domain protein
B657_07980	COG0726	polysaccharide deacetylase
B657_07990	COG2084	Dehydrogenase
B657_08000	COG0598	Magnesium transport protein CorA
B657_08010	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
B657_08020	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
B657_08030	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
B657_08040	COG4637	Psort location Cytoplasmic, score
B657_08060	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B657_08070	COG0022	dehydrogenase e1 component
B657_08080	COG0508	dehydrogenase complex catalyzes the overall conversion of
B657_08090	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B657_08100	COG3284	Transcriptional regulator
B657_08120	COG1742	UPF0060 membrane protein
B657_08170	COG4842	Belongs to the WXG100 family
B657_08180	COG1486	melibiose metabolic process
B657_08190	COG1737	Transcriptional regulator
B657_08200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B657_08200	COG1263	PTS System
B657_08210	COG1132	(ABC) transporter
B657_08220	COG1132	(ABC) transporter
B657_08230	COG2259	Doxx family
B657_08240	COG2514	catechol 2,3-dioxygenase activity
B657_08250	COG4977	sequence-specific DNA binding
B657_08250	COG1917	Cupin 2, conserved barrel domain protein
B657_08260	COG2814	Major facilitator Superfamily
B657_08270	COG1082	Xylose isomerase domain protein TIM barrel
B657_08280	COG0673	inositol 2-dehydrogenase activity
B657_08290	COG4585	Histidine kinase
B657_08300	COG2197	response regulator
B657_08310	COG1131	(ABC) transporter
B657_08320	COG1511	domain protein
B657_08320	COG0842	Transport permease protein
B657_08330	COG0842	Transport permease protein
B657_08340	COG1695	Transcriptional regulator
B657_08350	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
B657_08360	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
B657_08370	COG1309	transcriptional regulator
B657_08380	COG2814	Major facilitator Superfamily
B657_08390	COG2318	DinB family
B657_08400	COG2814	Major facilitator Superfamily
B657_08410	COG1846	Transcriptional regulator
B657_08425	COG0392	lysyltransferase activity
B657_08425	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
B657_08440	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B657_08450	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B657_08460	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B657_08470	COG0384	phenazine biosynthesis protein PhzF
B657_08480	COG0778	Nitroreductase
B657_08510	COG1090	epimerase
B657_08520	COG2137	regulation of response to DNA damage stimulus
B657_08540	COG2814	Major facilitator Superfamily
B657_08570	COG3103	Sh3 type 3 domain protein
B657_08580	COG5658	integral membrane protein
B657_08590	COG0596	Alpha beta hydrolase
B657_08600	COG0463	Glycosyl transferase, family 2
B657_08610	COG4485	Bacterial membrane protein, YfhO
B657_08620	COG1988	membrane-bound metal-dependent
B657_08630	COG1194	a g-specific adenine glycosylase
B657_08650	COG1028	Short-chain dehydrogenase reductase Sdr
B657_08680	COG3557	Belongs to the UPF0374 family
B657_08690	COG1132	(ABC) transporter
B657_08700	COG4129	membrane
B657_08710	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B657_08720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
B657_08730	COG0735	belongs to the Fur family
B657_08760	COG4326	sporulation control protein
B657_08779	COG5577	PFAM Coat F domain
B657_08780	COG3340	Belongs to the peptidase S51 family
B657_08790	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
B657_08800	COG0277	FAD linked oxidase domain protein
B657_08820	COG0753	catalase activity
B657_08830	COG1116	anion transmembrane transporter activity
B657_08840	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B657_08850	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B657_08860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B657_08880	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
B657_08899	COG1476	TRANSCRIPTIONal
B657_08900	COG3382	B3 4 domain protein
B657_08910	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
B657_08930	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
B657_08940	COG0789	Transcriptional regulator
B657_08950	COG1664	Polymer-forming cytoskeletal
B657_08960	COG1664	Polymer-forming cytoskeletal
B657_08970	COG2766	serine protein kinase
B657_08980	COG2718	Belongs to the UPF0229 family
B657_08990	COG1846	Transcriptional regulator
B657_09000	COG1566	PFAM secretion protein HlyD family protein
B657_09010	COG2814	Major facilitator Superfamily
B657_09020	COG0655	NAD(P)H dehydrogenase (quinone) activity
B657_09060	COG1725	Transcriptional regulator
B657_09070	COG1131	(ABC) transporter
B657_09080	COG1131	(ABC) transporter
B657_09090	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B657_09100	COG1278	Cold shock
B657_09110	COG1464	Belongs to the NlpA lipoprotein family
B657_09120	COG3706	GGDEF domain
B657_09130	COG1823	symporter activity
B657_09180	COG5577	PFAM Coat F domain
B657_09190	COG0737	Belongs to the 5'-nucleotidase family
B657_09190	COG1525	nuclease
B657_09190	COG4085	toxin activity
B657_09200	COG3764	Sortase (surface protein transpeptidase)
B657_09210	COG0564	pseudouridine synthase activity
B657_09230	COG0517	IMP dehydrogenase activity
B657_09240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B657_09250	COG3153	acetyltransferase
B657_09250	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B657_09260	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B657_09270	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
B657_09280	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
B657_09290	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
B657_09300	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
B657_09310	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
B657_09320	COG2203	Gaf domain
B657_09320	COG4585	Histidine kinase
B657_09330	COG2197	response regulator
B657_09340	COG0431	NADPH-dependent FMN reductase
B657_09370	COG0791	NLP P60 protein
B657_09370	COG1388	LysM domain
B657_09380	COG1959	2 iron, 2 sulfur cluster binding
B657_09390	COG0668	transmembrane transport
B657_09400	COG2719	SpoVR family
B657_09410	COG1785	Belongs to the alkaline phosphatase family
B657_09420	COG1388	LysM domain
B657_09420	COG0791	NLP P60 protein
B657_09430	COG0583	DNA-binding transcription factor activity
B657_09440	COG0372	Belongs to the citrate synthase family
B657_09450	COG1028	Short-chain dehydrogenase reductase Sdr
B657_09460	COG0531	amino acid
B657_09470	COG0733	neurotransmitter:sodium symporter activity
B657_09480	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B657_09490	COG0456	acetyltransferase
B657_09520	COG1595	DNA-templated transcription, initiation
B657_09530	COG0667	Aldo Keto reductase
B657_09540	COG0204	Acyl-transferase
B657_09550	COG1253	flavin adenine dinucleotide binding
B657_09560	COG0789	Transcriptional regulator
B657_09570	COG0436	Aminotransferase
B657_09590	COG1253	flavin adenine dinucleotide binding
B657_09600	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B657_09610	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
B657_09620	COG0584	glycerophosphoryl diester phosphodiesterase
B657_09640	COG0668	transmembrane transport
B657_09650	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
B657_09660	COG0726	polysaccharide deacetylase
B657_09670	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B657_09680	COG1757	Na H antiporter
B657_09690	COG0589	response to stress
B657_09710	COG1132	(ABC) transporter
B657_09730	COG0702	epimerase
B657_09770	COG0189	ligase activity
B657_09780	COG0189	ligase activity
B657_09790	COG4399	Belongs to the UPF0754 family
B657_09800	COG3679	Belongs to the UPF0342 family
B657_09810	COG4335	DNA alkylation repair
B657_09830	COG0561	phosphatase activity
B657_09840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
B657_09850	COG0475	glutathione-regulated potassium exporter activity
B657_09860	COG0490	domain, Protein
B657_09880	COG1024	Enoyl-CoA hydratase
B657_09890	COG4152	abc transporter atp-binding protein
B657_09900	COG1668	transmembrane transport
B657_09910	COG0420	3'-5' exonuclease activity
B657_09920	COG4717	serine-type aminopeptidase activity
B657_09930	COG3481	metal-dependent phosphohydrolase, HD sub domain
B657_09950	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
B657_09990	COG1846	Transcriptional regulator
B657_10000	COG4980	gas vesicle protein
B657_10020	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
B657_10030	COG0537	adenosine 5'-monophosphoramidase activity
B657_10040	COG1131	(ABC) transporter
B657_10050	COG4473	ABC transporter
B657_10070	COG1473	amidohydrolase
B657_10080	COG3069	C4-dicarboxylate transmembrane transporter activity
B657_10100	COG2329	Antibiotic biosynthesis monooxygenase
B657_10110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B657_10120	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
B657_10150	COG1309	transcriptional regulator
B657_10160	COG1511	domain protein
B657_10170	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B657_10180	COG4377	Putative membrane peptidase family (DUF2324)
B657_10200	COG1363	Peptidase, m42
B657_10210	COG4405	Protein conserved in bacteria
B657_10220	COG1301	dicarboxylic acid transport
B657_10240	COG1234	tRNA 3'-trailer cleavage
B657_10250	COG0095	Lipoate-protein ligase
B657_10260	COG0702	epimerase
B657_10270	COG0318	PFAM AMP-dependent synthetase and ligase
B657_10290	COG0501	Belongs to the peptidase M48B family
B657_10300	COG1404	Belongs to the peptidase S8 family
B657_10310	COG0456	acetyltransferase
B657_10320	COG0604	alcohol dehydrogenase
B657_10330	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
B657_10340	COG0406	alpha-ribazole phosphatase activity
B657_10350	COG0183	Belongs to the thiolase family
B657_10360	COG0318	PFAM AMP-dependent synthetase and ligase
B657_10370	COG1268	BioY protein
B657_10380	COG0840	transmembrane signaling receptor activity
B657_10390	COG0723	plastoquinol--plastocyanin reductase activity
B657_10390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B657_10400	COG1028	Short-chain dehydrogenase reductase Sdr
B657_10420	COG4903	ComK protein
B657_10430	COG1028	Short-chain dehydrogenase reductase Sdr
B657_10450	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B657_10480	COG0398	Pfam SNARE associated Golgi protein
B657_10490	COG0681	Belongs to the peptidase S26 family
B657_10500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
B657_10510	COG1846	Transcriptional regulator
B657_10520	COG0738	Major facilitator superfamily
B657_10530	COG0673	inositol 2-dehydrogenase activity
B657_10540	COG0561	phosphatase activity
B657_10550	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B657_10560	COG1609	Transcriptional regulator
B657_10570	COG3180	Ammonia monooxygenase
B657_10580	COG2814	Major facilitator Superfamily
B657_10580	COG0477	Major facilitator Superfamily
B657_10590	COG4533	DNA binding
B657_10610	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
B657_10620	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
B657_10630	COG1074	ATP-dependent DNA helicase activity
B657_10640	COG0420	3'-5' exonuclease activity
B657_10650	COG0419	ATPase involved in DNA repair
B657_10660	COG1403	HNH endonuclease
B657_10740	COG5337	Spore coat protein CotH
B657_10750	COG0179	Fumarylacetoacetate (FAA) hydrolase
B657_10770	COG1404	Belongs to the peptidase S8 family
B657_10790	COG0367	asparagine synthase
B657_10800	COG2318	DinB family
B657_10810	COG1562	ergosterol biosynthetic process
B657_10820	COG0534	Mate efflux family protein
B657_10830	COG2207	Transcriptional regulator
B657_10830	COG1917	Cupin 2, conserved barrel domain protein
B657_10840	COG1609	Transcriptional regulator
B657_10850	COG0673	inositol 2-dehydrogenase activity
B657_10860	COG2318	DinB family
B657_10870	COG1279	arginine transmembrane transporter activity
B657_10880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
B657_10890	COG1357	PFAM Pentapeptide repeats (8 copies)
B657_10900	COG2267	carboxylic ester hydrolase activity
B657_10910	COG0529	Catalyzes the synthesis of activated sulfate
B657_10920	COG2046	Belongs to the sulfate adenylyltransferase family
B657_10930	COG0175	sulfate reduction
B657_10940	COG2045	Belongs to the ComB family
B657_10950	COG1809	phosphosulfolactate synthase activity
B657_10960	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B657_10970	COG4948	Mandelate Racemase Muconate Lactonizing
B657_10980	COG2814	Major facilitator Superfamily
B657_10990	COG0454	-acetyltransferase
B657_11000	COG2153	protein acetylation
B657_11010	COG0646	methionine synthase
B657_11010	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
B657_11020	COG1666	GTP binding
B657_11030	COG2996	Protein conserved in bacteria
B657_11079	COG1695	Transcriptional regulator
B657_11100	COG3227	Zinc metalloprotease (Elastase)
B657_11110	COG1307	EDD domain protein, DegV family
B657_11120	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B657_11140	COG0561	phosphatase activity
B657_11150	COG1073	alpha beta
B657_11160	COG2151	metal-sulfur cluster biosynthetic enzyme
B657_11170	COG0277	FAD linked oxidase domain protein
B657_11180	COG2271	Major facilitator Superfamily
B657_11190	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
B657_11220	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B657_11230	COG0505	Belongs to the CarA family
B657_11240	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B657_11250	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
B657_11280	COG2267	carboxylic ester hydrolase activity
B657_11300	COG1744	ABC transporter substrate-binding protein PnrA-like
B657_11330	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B657_11340	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B657_11350	COG5504	Zn-dependent protease
B657_11360	COG0444	Belongs to the ABC transporter superfamily
B657_11370	COG4608	Belongs to the ABC transporter superfamily
B657_11390	COG0601	transmembrane transport
B657_11400	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B657_11420	COG0180	Tryptophanyl-tRNA synthetase
B657_11430	COG4166	transmembrane transport
B657_11440	COG0601	transmembrane transport
B657_11450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B657_11460	COG0444	Belongs to the ABC transporter superfamily
B657_11470	COG4608	Belongs to the ABC transporter superfamily
B657_11480	COG2814	Major facilitator Superfamily
B657_11490	COG0456	acetyltransferase
B657_11500	COG1393	Belongs to the ArsC family
B657_11510	COG0861	Integral membrane protein TerC family
B657_11520	COG4862	establishment of competence for transformation
B657_11530	COG4469	Competence protein
B657_11540	COG1164	Oligoendopeptidase f
B657_11560	COG2346	COG2346, Truncated hemoglobins
B657_11570	COG0741	lytic transglycosylase activity
B657_11580	COG4116	CYTH
B657_11600	COG2357	RelA SpoT domain protein
B657_11610	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B657_11620	COG0564	pseudouridine synthase activity
B657_11630	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
B657_11640	COG0569	domain protein
B657_11640	COG0475	glutathione-regulated potassium exporter activity
B657_11650	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
B657_11660	COG0352	thiamine-phosphate diphosphorylase activity
B657_11670	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B657_11680	COG2104	thiamine diphosphate biosynthetic process
B657_11690	COG2022	thiamine diphosphate biosynthetic process
B657_11700	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B657_11710	COG0351	phosphomethylpyrimidine kinase
B657_11720	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
B657_11820	COG0210	DNA helicase
B657_11840	COG2153	protein acetylation
B657_11850	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B657_11860	COG2382	esterase
B657_11870	COG0626	cystathionine gamma-synthase activity
B657_11880	COG0626	cystathionine gamma-synthase activity
B657_11890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B657_11900	COG5505	Protein of unknown function (DUF819)
B657_11930	COG3677	Transposase
B657_11960	COG5484	DNA packaging
B657_11970	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
B657_11980	COG1028	Short-chain dehydrogenase reductase Sdr
B657_12000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B657_12000	COG3711	transcriptional antiterminator
B657_12010	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B657_12010	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B657_12010	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B657_12020	COG1482	cell wall glycoprotein biosynthetic process
B657_12040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B657_12060	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B657_12080	COG0109	protoheme IX farnesyltransferase activity
B657_12100	COG0726	polysaccharide deacetylase
B657_12130	COG5504	Zn-dependent protease
B657_12140	COG2205	protein histidine kinase activity
B657_12160	COG3383	formate dehydrogenase (NAD+) activity
B657_12170	COG2427	Protein of unknown function (DUF1641)
B657_12190	COG1051	belongs to the nudix hydrolase family
B657_12210	COG2124	cytochrome p450
B657_12220	COG1819	glycosyl
B657_12230	COG1587	Uroporphyrinogen-III synthase
B657_12240	COG0390	transport system, permease component
B657_12250	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B657_12260	COG0697	spore germination
B657_12270	COG4297	protein containing double-stranded beta helix domain
B657_12290	COG1252	NADH dehydrogenase
B657_12300	COG1904	glucuronate isomerase
B657_12310	COG2211	Major facilitator Superfamily
B657_12320	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
B657_12330	COG1063	alcohol dehydrogenase
B657_12340	COG1312	Catalyzes the dehydration of D-mannonate
B657_12350	COG1028	Short-chain dehydrogenase reductase Sdr
B657_12360	COG2271	Major facilitator Superfamily
B657_12370	COG1609	Transcriptional regulator
B657_12380	COG0246	Mannitol dehydrogenase
B657_12390	COG2721	sulfolactate sulfo-lyase activity
B657_12400	COG0730	response to heat
B657_12410	COG2318	DinB family
B657_12420	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
B657_12430	COG0457	Tetratricopeptide repeat
B657_12450	COG2350	Protein conserved in bacteria
B657_12460	COG1388	LysM domain
B657_12460	COG3409	Peptidoglycan-binding domain 1 protein
B657_12460	COG5632	N-Acetylmuramoyl-L-alanine amidase
B657_12480	COG4195	phage-related replication protein
B657_12490	COG3546	catalase activity
B657_12500	COG2856	Zn peptidase
B657_12510	COG1396	sequence-specific DNA binding
B657_12520	COG1522	sequence-specific DNA binding
B657_12530	COG1484	DNA-dependent DNA replication
B657_12560	COG1595	DNA-templated transcription, initiation
B657_12570	COG5484	DNA packaging
B657_12570	COG3728	DNA packaging
B657_12580	COG1783	phage Terminase large subunit
B657_12590	COG5518	Phage portal protein
B657_12600	COG0338	D12 class N6 adenine-specific DNA methyltransferase
B657_12610	COG4653	Phage capsid family
B657_12680	COG3953	SLT domain
B657_12680	COG5412	phage tail tape measure protein
B657_12690	COG1652	LysM domain
B657_12700	COG4193	domain, Protein
B657_12720	COG3628	GPW Gp25 family protein
B657_12730	COG3299	homolog of phage Mu protein gp47
B657_12740	COG3778	Protein conserved in bacteria
B657_12810	COG5632	N-Acetylmuramoyl-L-alanine amidase
B657_12810	COG3409	Peptidoglycan-binding domain 1 protein
B657_12840	COG0306	phosphate transporter
B657_12850	COG1392	Phosphate transport regulator
B657_12860	COG0531	amino acid
B657_12870	COG0346	lactoylglutathione lyase activity
B657_12880	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B657_12890	COG0463	Glycosyl transferase, family 2
B657_12900	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B657_12910	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B657_12920	COG2362	D-Aminopeptidase
B657_12930	COG0601	transmembrane transport
B657_12940	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
B657_12950	COG0444	Belongs to the ABC transporter superfamily
B657_12960	COG4166	transmembrane transport
B657_12970	COG1619	proteins homologs of microcin C7 resistance protein MccF
B657_12980	COG4948	Mandelate Racemase Muconate Lactonizing
B657_12990	COG0791	NLP P60 protein
B657_13000	COG4608	Belongs to the ABC transporter superfamily
B657_13010	COG2706	6-phosphogluconolactonase activity
B657_13020	COG1834	amidinotransferase
B657_13030	COG1607	acyl-coa hydrolase
B657_13040	COG1017	nitric oxide dioxygenase activity
B657_13040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
B657_13060	COG2323	membrane
B657_13070	COG2318	DinB family
B657_13080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B657_13090	COG2076	Multidrug Resistance protein
B657_13100	COG2076	Multidrug Resistance protein
B657_13110	COG0788	formyltetrahydrofolate deformylase activity
B657_13120	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B657_13130	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
B657_13140	COG1764	response to oxidative stress
B657_13150	COG1846	Transcriptional regulator
B657_13160	COG1764	response to oxidative stress
B657_13170	COG0590	tRNA wobble adenosine to inosine editing
B657_13180	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B657_13190	COG1404	Belongs to the peptidase S8 family
B657_13200	COG1366	Belongs to the anti-sigma-factor antagonist family
B657_13210	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
B657_13220	COG1122	ATPase activity
B657_13230	COG4721	ABC-type cobalt transport system, permease component
B657_13250	COG0745	RESPONSE REGULATOR receiver
B657_13260	COG3850	Histidine kinase
B657_13260	COG5002	protein histidine kinase activity
B657_13270	COG3212	peptidase
B657_13280	COG3212	peptidase
B657_13300	COG2239	Acts as a magnesium transporter
B657_13310	COG0789	Transcriptional regulator
B657_13340	COG1846	Transcriptional regulator
B657_13350	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B657_13360	COG0726	polysaccharide deacetylase
B657_13370	COG1408	metallophosphoesterase
B657_13390	COG0463	Glycosyl transferase, family 2
B657_13400	COG3285	dna ligase
B657_13400	COG1793	dna ligase
B657_13410	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
B657_13420	COG3300	MHYT domain
B657_13420	COG5001	Diguanylate cyclase
B657_13430	COG0586	Pfam SNARE associated Golgi protein
B657_13440	COG0861	Integral membrane protein TerC family
B657_13450	COG1191	sigma factor activity
B657_13490	COG0501	Belongs to the peptidase M48B family
B657_13500	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B657_13520	COG3594	Acyltransferase
B657_13530	COG5002	protein histidine kinase activity
B657_13540	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
B657_13550	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
B657_13560	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
B657_13570	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
B657_13580	COG0436	Aminotransferase
B657_13590	COG1850	ribulose-bisphosphate carboxylase activity
B657_13600	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
B657_13610	COG0235	Class ii aldolase
B657_13620	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
B657_13630	COG3339	Conserved Protein
B657_13660	COG3852	Histidine kinase
B657_13670	COG1846	Transcriptional regulator
B657_13680	COG1360	Flagellar Motor Protein
B657_13690	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B657_13700	COG0542	response to heat
B657_13710	COG3949	Membrane
B657_13720	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
B657_13730	COG0720	synthase
B657_13740	COG0602	queuosine metabolic process
B657_13750	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
B657_13760	COG1733	regulation of RNA biosynthetic process
B657_13770	COG1028	Short-chain dehydrogenase reductase Sdr
B657_13780	COG4641	Protein conserved in bacteria
B657_13780	COG1388	LysM domain
B657_13789	COG1388	LysM domain
B657_13790	COG3858	chitin binding
B657_13799	COG3858	chitin binding
B657_13810	COG4873	Protein conserved in bacteria
B657_13820	COG3773	Cell wall hydrolase
B657_13830	COG2244	polysaccharide biosynthetic process
B657_13840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B657_13850	COG2217	Heavy metal translocating P-type atpase
B657_13860	COG0006	proline dipeptidase activity
B657_13870	COG1609	Transcriptional regulator
B657_13880	COG3711	transcriptional antiterminator
B657_13890	COG1263	PTS System
B657_13890	COG2190	(PTS) system
B657_13890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B657_13900	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B657_13910	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
B657_13930	COG1533	DNA photolyase activity
B657_13940	COG0456	acetyltransferase
B657_13950	COG0840	transmembrane signaling receptor activity
B657_13960	COG2084	Dehydrogenase
B657_13970	COG2340	Cysteine-rich secretory protein family
B657_13980	COG0768	penicillin binding
B657_13990	COG4191	Histidine kinase
B657_14000	COG0436	Aminotransferase
B657_14010	COG0835	chemotaxis
B657_14010	COG0784	Response regulator, receiver
B657_14030	COG2814	Major facilitator Superfamily
B657_14040	COG1376	ErfK ybiS ycfS ynhG family protein
B657_14050	COG1408	metallophosphoesterase
B657_14060	COG1028	Short-chain dehydrogenase reductase Sdr
B657_14071	COG3409	Peptidoglycan-binding domain 1 protein
B657_14072	COG3409	Peptidoglycan-binding domain 1 protein
B657_14090	COG2200	EAL domain
B657_14100	COG4703	Protein of unknown function (DUF1797)
B657_14110	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
B657_14130	COG0517	IMP dehydrogenase activity
B657_14140	COG0583	DNA-binding transcription factor activity
B657_14150	COG0716	FMN binding
B657_14170	COG0716	FMN binding
B657_14180	COG2171	N-acyltransferase activity
B657_14190	COG1473	amidohydrolase
B657_14210	COG0668	transmembrane transport
B657_14220	COG0450	alkyl hydroperoxide reductase
B657_14230	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B657_14260	COG0746	molybdenum cofactor guanylyltransferase activity
B657_14270	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
B657_14280	COG0303	'Molybdopterin
B657_14290	COG1763	Mo-molybdopterin cofactor biosynthetic process
B657_14300	COG0314	molybdopterin synthase activity
B657_14310	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
B657_14320	COG1132	(ABC) transporter
B657_14330	COG1132	(ABC) transporter
B657_14350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B657_14360	COG1136	(ABC) transporter
B657_14370	COG0577	efflux transmembrane transporter activity
B657_14380	COG1349	DNA-binding transcription factor activity
B657_14390	COG1105	Belongs to the carbohydrate kinase PfkB family
B657_14400	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B657_14400	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
B657_14400	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B657_14410	COG0681	Belongs to the peptidase S26 family
B657_14430	COG0488	(ABC) transporter
B657_14440	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B657_14450	COG2309	aminopeptidase activity
B657_14470	COG1077	Cell shape determining protein MreB Mrl
B657_14480	COG2002	toxin-antitoxin pair type II binding
B657_14490	COG3852	Histidine kinase
B657_14500	COG2105	PFAM AIG2 family protein
B657_14500	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
B657_14510	COG0569	domain protein
B657_14520	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
B657_14530	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B657_14550	COG0561	phosphatase activity
B657_14560	COG0242	peptide deformylase activity
B657_14570	COG0497	DNA recombination
B657_14580	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B657_14590	COG0022	dehydrogenase e1 component
B657_14600	COG0508	dehydrogenase complex catalyzes the overall conversion of
B657_14610	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B657_14620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B657_14630	COG1982	Orn Lys Arg decarboxylase major
B657_14640	COG4476	Belongs to the UPF0223 family
B657_14650	COG4493	Belongs to the UPF0637 family
B657_14670	COG0483	inositol monophosphate 1-phosphatase activity
B657_14690	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
B657_14730	COG1595	DNA-templated transcription, initiation
B657_14790	COG4896	Protein conserved in bacteria
B657_14810	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
B657_14820	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B657_14830	COG2066	Belongs to the glutaminase family
B657_14840	COG4838	Belongs to the UPF0358 family
B657_14850	COG0772	Belongs to the SEDS family
B657_14860	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
B657_14870	COG1612	heme a metabolic process
B657_14880	COG0109	protoheme IX farnesyltransferase activity
B657_14890	COG2010	Cytochrome c
B657_14890	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B657_14900	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B657_14910	COG1845	cytochrome c oxidase, subunit III
B657_14920	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B657_14930	COG3336	cytochrome c oxidase
B657_14950	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
B657_14960	COG2340	Cysteine-rich secretory protein family
B657_14990	COG3679	Belongs to the UPF0342 family
B657_15000	COG4471	UPF0298 protein
B657_15010	COG0742	ribosomal rna small subunit methyltransferase
B657_15020	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
B657_15030	COG3314	Sporulation integral membrane protein YlbJ
B657_15040	COG1752	Esterase of the alpha-beta hydrolase superfamily
B657_15050	COG3480	Lon protease (S16) C-terminal proteolytic domain
B657_15060	COG1323	Belongs to the UPF0348 family
B657_15070	COG1399	metal-binding, possibly nucleic acid-binding protein
B657_15080	COG0333	Belongs to the bacterial ribosomal protein bL32 family
B657_15100	COG0454	-acetyltransferase
B657_15110	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
B657_15120	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
B657_15130	COG2001	Belongs to the MraZ family
B657_15140	COG0275	rRNA processing
B657_15150	COG4839	cell division protein FtsL
B657_15170	COG0768	penicillin binding
B657_15180	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
B657_15190	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B657_15200	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B657_15210	COG0772	Belongs to the SEDS family
B657_15220	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B657_15230	COG0812	UDP-N-acetylmuramate dehydrogenase activity
B657_15240	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
B657_15250	COG3879	Bacterial protein of unknown function (DUF881)
B657_15260	COG3879	Bacterial protein of unknown function (DUF881)
B657_15270	COG3856	small basic protein
B657_15280	COG0849	cell division
B657_15290	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
B657_15300	COG4412	M6 family metalloprotease domain protein
B657_15300	COG1404	Belongs to the peptidase S8 family
B657_15320	COG1191	sigma factor activity
B657_15330	COG1191	sigma factor activity
B657_15340	COG1119	ATPase activity
B657_15350	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B657_15360	COG1873	PFAM PRC-barrel domain
B657_15380	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
B657_15390	COG1799	cell septum assembly
B657_15400	COG0762	integral membrane protein
B657_15410	COG2302	S4 RNA-binding domain
B657_15420	COG3599	regulation of cell shape
B657_15430	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
B657_15440	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B657_15450	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
B657_15460	COG0564	pseudouridine synthase activity
B657_15470	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
B657_15480	COG2233	PERMEase
B657_15490	COG0540	Belongs to the ATCase OTCase family
B657_15500	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B657_15510	COG0505	Belongs to the CarA family
B657_15520	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B657_15530	COG0543	2 iron, 2 sulfur cluster binding
B657_15540	COG0167	dihydroorotate dehydrogenase activity
B657_15550	COG0284	orotidine-5'-phosphate decarboxylase activity
B657_15560	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
B657_15570	COG0175	sulfate reduction
B657_15580	COG0306	phosphate transporter
B657_15590	COG2046	Belongs to the sulfate adenylyltransferase family
B657_15600	COG0529	Catalyzes the synthesis of activated sulfate
B657_15610	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
B657_15620	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
B657_15630	COG1648	precorrin-2 dehydrogenase activity
B657_15650	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B657_15660	COG1561	YicC-like family, N-terminal region
B657_15670	COG2052	Domain of unknown function (DUF370)
B657_15680	COG0194	GDP metabolic process
B657_15690	COG1758	RNA polymerase activity
B657_15700	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B657_15710	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
B657_15720	COG0242	peptide deformylase activity
B657_15730	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
B657_15740	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B657_15740	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
B657_15750	COG0820	rRNA (adenine-C2-)-methyltransferase activity
B657_15760	COG0631	protein serine/threonine phosphatase activity
B657_15770	COG0515	serine threonine protein kinase
B657_15770	COG2815	serine threonine protein kinase
B657_15780	COG1162	GTPase activity
B657_15790	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
B657_15800	COG1564	THIamine pyrophosphokinase
B657_15820	COG0227	Belongs to the bacterial ribosomal protein bL28 family
B657_15830	COG1302	Protein conserved in bacteria
B657_15840	COG1461	Dihydroxyacetone kinase
B657_15850	COG1760	l-serine dehydratase
B657_15860	COG1760	l-serine dehydratase
B657_15870	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
B657_15880	COG2050	protein possibly involved in aromatic compounds catabolism
B657_15880	COG1349	DNA-binding transcription factor activity
B657_15890	COG0416	fatty acid biosynthetic process
B657_15900	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B657_15910	COG1028	Short-chain dehydrogenase reductase Sdr
B657_15920	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B657_15930	COG0571	ribonuclease III activity
B657_15940	COG1196	nuclear chromosome segregation
B657_15950	COG0552	protein localization to endoplasmic reticulum
B657_15970	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
B657_15980	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
B657_15990	COG0228	four-way junction DNA binding
B657_16000	COG1837	Belongs to the UPF0109 family
B657_16020	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
B657_16030	COG0336	Belongs to the RNA methyltransferase TrmD family
B657_16040	COG0335	large ribosomal subunit rRNA binding
B657_16050	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
B657_16060	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B657_16080	COG2257	FlhB HrpN YscU SpaS Family
B657_16090	COG0045	succinate-CoA ligase (ADP-forming) activity
B657_16100	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
B657_16110	COG0758	DNA mediated transformation
B657_16120	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
B657_16130	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
B657_16140	COG4974	Belongs to the 'phage' integrase family
B657_16150	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
B657_16160	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
B657_16170	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
B657_16180	COG1815	bacterial-type flagellum-dependent cell motility
B657_16190	COG1558	bacterial-type flagellum-dependent cell motility
B657_16200	COG1677	Flagellar hook-basal body complex protein FliE
B657_16210	COG1766	The M ring may be actively involved in energy transduction
B657_16220	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B657_16230	COG1317	bacterial-type flagellum organization
B657_16240	COG1157	protein secretion by the type III secretion system
B657_16250	COG2882	bacterial-type flagellum organization
B657_16260	COG3334	PFAM MgtE intracellular
B657_16270	COG3144	bacterial-type flagellum assembly
B657_16280	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
B657_16290	COG4786	Flagellar basal body rod
B657_16299	COG1582	Flagellar protein (FlbD)
B657_16300	COG1580	Controls the rotational direction of flagella during chemotaxis
B657_16310	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B657_16320	COG1776	CheC inhibitor of MCP methylation
B657_16320	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
B657_16330	COG2201	protein-glutamate methylesterase activity
B657_16340	COG3190	flagellar
B657_16350	COG1338	Plays a role in the flagellum-specific transport system
B657_16360	COG1987	bacterial-type flagellum assembly
B657_16370	COG1684	flagellar biosynthetic protein fliR
B657_16380	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B657_16390	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
B657_16400	COG1419	protein localization to endoplasmic reticulum
B657_16410	COG0455	bacterial-type flagellum organization
B657_16420	COG2201	protein-glutamate methylesterase activity
B657_16430	COG2198	Histidine kinase
B657_16430	COG0643	Histidine kinase
B657_16440	COG0835	chemotaxis
B657_16450	COG1776	CheC inhibitor of MCP methylation
B657_16460	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
B657_16470	COG1191	sigma factor activity
B657_16490	COG0052	Belongs to the universal ribosomal protein uS2 family
B657_16500	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
B657_16510	COG0528	UMP kinase activity
B657_16520	COG0233	cytoplasmic translational termination
B657_16530	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
B657_16540	COG4589	Belongs to the CDS family
B657_16550	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
B657_16560	COG0750	zinc metalloprotease
B657_16570	COG0442	prolyl-tRNA aminoacylation
B657_16580	COG2176	DNA-directed DNA polymerase activity
B657_16590	COG0779	Required for maturation of 30S ribosomal subunits
B657_16600	COG0195	Participates in both transcription termination and antitermination
B657_16610	COG2740	Nucleic-acid-binding protein implicated in transcription termination
B657_16620	COG1358	cellular component organization or biogenesis
B657_16630	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
B657_16640	COG1550	Protein conserved in bacteria
B657_16650	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
B657_16660	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
B657_16670	COG0196	riboflavin kinase activity
B657_16680	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
B657_16690	COG1185	polyribonucleotide nucleotidyltransferase activity
B657_16700	COG0726	polysaccharide deacetylase
B657_16710	COG0612	Peptidase, M16
B657_16720	COG1873	PFAM PRC-barrel domain
B657_16730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B657_16740	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
B657_16750	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
B657_16760	COG0527	aspartate kinase activity
B657_16770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
B657_16780	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
B657_16790	COG0740	serine-type endopeptidase activity
B657_16800	COG1674	ftsk spoiiie
B657_16800	COG4980	gas vesicle protein
B657_16810	COG2188	Transcriptional regulator
B657_16825	COG2814	Major facilitator Superfamily
B657_16845	COG0612	Peptidase, M16
B657_16860	COG0612	Peptidase, M16
B657_16870	COG0300	oxidoreductase activity
B657_16910	COG1426	Protein conserved in bacteria
B657_16920	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
B657_16930	COG1546	Belongs to the CinA family
B657_16930	COG1058	Belongs to the CinA family
B657_16940	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
B657_16950	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B657_16960	COG1418	mRNA catabolic process
B657_16970	COG1692	metallophosphoesterase
B657_16980	COG2359	stage V sporulation protein S
B657_16990	COG1063	alcohol dehydrogenase
B657_17000	COG0156	8-amino-7-oxononanoate synthase activity
B657_17010	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
B657_17020	COG4550	Control of competence regulator ComK, YlbF/YmcA
B657_17040	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
B657_17050	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
B657_17080	COG3226	Transcriptional regulator
B657_17090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B657_17100	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B657_17110	COG3321	synthase
B657_17120	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
B657_17120	COG2070	2-Nitropropane dioxygenase
B657_17130	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B657_17140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
B657_17150	COG3425	synthase
B657_17160	COG1024	Enoyl-CoA hydratase
B657_17170	COG1024	Enoyl-CoA hydratase
B657_17180	COG3321	synthase
B657_17180	COG0318	PFAM AMP-dependent synthetase and ligase
B657_17180	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B657_17180	COG0300	oxidoreductase activity
B657_17180	COG1028	Short-chain dehydrogenase reductase Sdr
B657_17190	COG4221	oxidoreductase activity
B657_17190	COG3321	synthase
B657_17190	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B657_17190	COG0300	oxidoreductase activity
B657_17200	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B657_17200	COG3321	synthase
B657_17200	COG1028	Short-chain dehydrogenase reductase Sdr
B657_17200	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B657_17200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B657_17220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B657_17220	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
B657_17220	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
B657_17220	COG3321	synthase
B657_17230	COG2124	cytochrome p450
B657_17250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B657_17260	COG1404	Belongs to the peptidase S8 family
B657_17270	COG4195	phage-related replication protein
B657_17280	COG1764	response to oxidative stress
B657_17290	COG2076	Multidrug Resistance protein
B657_17300	COG2076	Multidrug Resistance protein
B657_17330	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
B657_17340	COG1923	regulation of RNA biosynthetic process
B657_17370	COG1780	Probably involved in ribonucleotide reductase function
B657_17380	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B657_17390	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
B657_17400	COG4112	unkown
B657_17410	COG0860	N-Acetylmuramoyl-L-alanine amidase
B657_17420	COG0464	growth
B657_17430	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
B657_17440	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
B657_17450	COG0789	Transcriptional regulator
B657_17460	COG0174	glutamine synthetase
B657_17500	COG4282	regulation of fungal-type cell wall biogenesis
B657_17520	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B657_17560	COG0135	phosphoribosylanthranilate isomerase activity
B657_17570	COG2211	Major facilitator Superfamily
B657_17580	COG3507	Belongs to the glycosyl hydrolase 43 family
B657_17590	COG1940	carbohydrate kinase activity
B657_17600	COG2115	Belongs to the xylose isomerase family
B657_17610	COG1070	Carbohydrate kinase
B657_17620	COG1525	nuclease
B657_17630	COG2814	Major facilitator Superfamily
B657_17640	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
B657_17660	COG0756	dUTP diphosphatase activity
B657_17680	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B657_17710	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
B657_17730	COG3832	glyoxalase III activity
B657_17750	COG0697	spore germination
B657_17760	COG0531	amino acid
B657_17820	COG4195	phage-related replication protein
B657_17840	COG0346	lactoylglutathione lyase activity
B657_17850	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
B657_17860	COG1388	LysM domain
B657_17870	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B657_17880	COG4224	UPF0291 protein
B657_17890	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
B657_17910	COG3763	UPF0154 protein
B657_17930	COG0785	Cytochrome C biogenesis protein
B657_17940	COG2201	protein-glutamate methylesterase activity
B657_17950	COG4846	Membrane protein involved in cytochrome C biogenesis
B657_17970	COG0071	Belongs to the small heat shock protein (HSP20) family
B657_18000	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
B657_18010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B657_18040	COG0824	Thioesterase
B657_18060	COG4841	protein insertion into membrane
B657_18070	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
B657_18080	COG1832	CoA-binding protein
B657_18090	COG0187	DNA topoisomerase II activity
B657_18100	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
B657_18120	COG1115	amino acid carrier protein
B657_18130	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
B657_18150	COG5520	Belongs to the glycosyl hydrolase 30 family
B657_18160	COG3507	Belongs to the glycosyl hydrolase 43 family
B657_18170	COG2246	polysaccharide biosynthetic process
B657_18180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B657_18190	COG0586	Pfam SNARE associated Golgi protein
B657_18200	COG2404	hydrolase activity, acting on ester bonds
B657_18210	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B657_18220	COG1024	Enoyl-CoA hydratase
B657_18230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B657_18239	COG0511	ligase activity, forming carbon-carbon bonds
B657_18240	COG0439	Biotin carboxylase
B657_18250	COG0318	PFAM AMP-dependent synthetase and ligase
B657_18260	COG1960	acyl-CoA dehydrogenase activity
B657_18280	COG1649	PFAM Uncharacterised BCR, COG1649
B657_18300	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
B657_18300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B657_18310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B657_18320	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B657_18330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B657_18350	COG2027	D-alanyl-D-alanine carboxypeptidase
B657_18360	COG2017	converts alpha-aldose to the beta-anomer
B657_18370	COG0534	Mate efflux family protein
B657_18390	COG0582	viral genome integration into host DNA
B657_18400	COG0166	Belongs to the GPI family
B657_18410	COG0405	Gamma-glutamyltransferase
B657_18420	COG0583	DNA-binding transcription factor activity
B657_18450	COG0067	glutamate synthase
B657_18450	COG0069	glutamate synthase activity
B657_18450	COG0070	glutamate synthase
B657_18460	COG0583	DNA-binding transcription factor activity
B657_18470	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
B657_18480	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B657_18500	COG0300	oxidoreductase activity
B657_18510	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
B657_18530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B657_18540	COG2814	Major facilitator Superfamily
B657_18550	COG1070	Carbohydrate kinase
B657_18560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B657_18570	COG0243	molybdopterin cofactor binding
B657_18610	COG5278	phosphoserine phosphatase activity
B657_18610	COG0840	transmembrane signaling receptor activity
B657_18620	COG2368	4-hydroxyphenylacetate
B657_18630	COG4305	rare lipoprotein A
B657_18640	COG3619	membrane
B657_18650	COG3866	Pectate lyase
B657_18660	COG2135	peptidase activity
B657_18670	COG2140	Oxalate decarboxylase
B657_18690	COG0456	acetyltransferase
B657_18720	COG2720	vancomycin resistance protein
B657_18740	COG3655	Transcriptional regulator
B657_18750	COG3739	integral membrane protein
B657_18760	COG0583	DNA-binding transcription factor activity
B657_18770	COG0697	spore germination
B657_18790	COG0693	protein deglycase activity
B657_18800	COG2367	Beta-lactamase
B657_18830	COG0574	Belongs to the PEP-utilizing enzyme family
B657_18830	COG3848	Pyruvate phosphate dikinase
B657_18840	COG0726	polysaccharide deacetylase
B657_18849	COG2314	TM2 domain
B657_18850	COG1396	sequence-specific DNA binding
B657_18880	COG2135	peptidase activity
B657_18910	COG0457	Tetratricopeptide repeat
B657_18930	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B657_18940	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B657_18970	COG5290	Psort location Cytoplasmic, score
B657_19000	COG5444	nuclease activity
B657_19010	COG4282	regulation of fungal-type cell wall biogenesis
B657_19020	COG1231	oxidoreductase activity
B657_19030	COG5434	Belongs to the glycosyl hydrolase 28 family
B657_19040	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B657_19050	COG0662	Cupin 2, conserved barrel domain protein
B657_19050	COG2207	Transcriptional regulator
B657_19060	COG0456	acetyltransferase
B657_19070	COG1309	transcriptional regulator
B657_19080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B657_19090	COG3708	Transcriptional regulator
B657_19100	COG2378	regulation of single-species biofilm formation
B657_19120	COG0640	Transcriptional regulator
B657_19130	COG0741	lytic transglycosylase activity
B657_19140	COG2322	membrane
B657_19170	COG1619	proteins homologs of microcin C7 resistance protein MccF
B657_19180	COG3239	Fatty acid desaturase
B657_19190	COG4585	Histidine kinase
B657_19200	COG2197	response regulator
B657_19210	COG3584	3D domain protein
B657_19210	COG1388	LysM domain
B657_19220	COG0514	ATP-dependent DNA helicase (RecQ)
B657_19230	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B657_19240	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B657_19260	COG0071	Belongs to the small heat shock protein (HSP20) family
B657_19310	COG1012	belongs to the aldehyde dehydrogenase family
B657_19320	COG1657	PFAM Prenyltransferase squalene oxidase
B657_19330	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B657_19340	COG0733	neurotransmitter:sodium symporter activity
B657_19350	COG0385	Bile acid
B657_19360	COG0508	dehydrogenase complex catalyzes the overall conversion of
B657_19370	COG0567	Dehydrogenase, E1 component
B657_19380	COG4548	von Willebrand factor, type A
B657_19390	COG0714	Associated with various cellular activities
B657_19400	COG2032	superoxide dismutase activity
B657_19410	COG1388	LysM domain
B657_19410	COG0791	NLP P60 protein
B657_19420	COG1819	glycosyl
B657_19430	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
B657_19440	COG0534	Mate efflux family protein
B657_19450	COG1366	Belongs to the anti-sigma-factor antagonist family
B657_19460	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B657_19470	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B657_19480	COG2962	Rard protein
B657_19520	COG2610	gluconate transmembrane transporter activity
B657_19530	COG1942	4-Oxalocrotonate Tautomerase
B657_19540	COG1733	regulation of RNA biosynthetic process
B657_19550	COG0778	Nitroreductase
B657_19560	COG0400	carboxylic ester hydrolase activity
B657_19570	COG0346	lactoylglutathione lyase activity
B657_19580	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B657_19590	COG3409	Peptidoglycan-binding domain 1 protein
B657_19590	COG0793	Belongs to the peptidase S41A family
B657_19600	COG2226	methyltransferase
B657_19620	COG1876	peptidase activity
B657_19630	COG0813	purine-nucleoside phosphorylase activity
B657_19650	COG0671	phosphoesterase, PA-phosphatase related
B657_19680	COG4479	Belongs to the UPF0346 family
B657_19690	COG1509	lysine 2,3-aminomutase activity
B657_19700	COG0456	acetyltransferase
B657_19710	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B657_19720	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B657_19730	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B657_19740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B657_19750	COG0456	acetyltransferase
B657_19760	COG0463	Glycosyl transferase, family 2
B657_19790	COG4641	Protein conserved in bacteria
B657_19800	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
B657_19830	COG3331	DNA recombination
B657_19940	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B657_20010	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
B657_20020	COG0756	dUTP diphosphatase activity
B657_20030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B657_20070	COG1780	Probably involved in ribonucleotide reductase function
B657_20250	COG0270	DNA (cytosine-5-)-methyltransferase activity
B657_20270	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
B657_20280	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
B657_20330	COG3584	3D domain protein
B657_20340	COG0587	DNA-directed DNA polymerase activity
B657_20350	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B657_20360	COG0358	DNA primase activity
B657_20370	COG0305	Participates in initiation and elongation during chromosome replication
B657_20390	COG2887	Belongs to the helicase family. UvrD subfamily
B657_20450	COG3420	alginic acid biosynthetic process
B657_20450	COG5434	Belongs to the glycosyl hydrolase 28 family
B657_20460	COG4195	phage-related replication protein
B657_20490	COG2135	peptidase activity
B657_20500	COG1793	dna ligase
B657_20610	COG4474	Belongs to the UPF0398 family
B657_20630	COG1388	LysM domain
B657_20670	COG3646	Phage regulatory protein
B657_20670	COG3645	SOS response
B657_20780	COG3655	Transcriptional regulator
B657_20810	COG0582	viral genome integration into host DNA
B657_20950	COG3655	Transcriptional regulator
B657_21020	COG1395	domain, Protein
B657_21050	COG0776	regulation of translation
B657_21110	COG4373	Mu-like prophage FluMu protein gp28
B657_21300	COG0582	viral genome integration into host DNA
B657_21350	COG1196	nuclear chromosome segregation
B657_21350	COG0741	lytic transglycosylase activity
B657_21350	COG0739	heme binding
B657_21370	COG2433	Pfam Transposase IS66
B657_21390	COG4632	Exopolysaccharide biosynthesis protein
B657_21390	COG5434	Belongs to the glycosyl hydrolase 28 family
B657_21410	COG5632	N-Acetylmuramoyl-L-alanine amidase
B657_21440	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B657_21450	COG0463	Glycosyl transferase, family 2
B657_21460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B657_21470	COG3271	cysteine-type peptidase activity
B657_21470	COG2274	protein secretion by the type I secretion system
B657_21500	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B657_21550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
B657_21580	COG5444	nuclease activity
B657_21590	COG4282	regulation of fungal-type cell wall biogenesis
B657_21610	COG1525	nuclease
B657_21630	COG2746	aminoglycoside 3-N-acetyltransferase activity
B657_21660	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
B657_21680	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B657_21690	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
B657_21700	COG1846	Transcriptional regulator
B657_21710	COG0534	Mate efflux family protein
B657_21730	COG4698	Protein conserved in bacteria
B657_21740	COG2755	lipolytic protein G-D-S-L family
B657_21750	COG1999	signal sequence binding
B657_21770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
B657_21780	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B657_21790	COG1272	protein, Hemolysin III
B657_21800	COG0204	Acyl-transferase
B657_21810	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B657_21820	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
B657_21830	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B657_21850	COG2521	methyltransferase
B657_21850	COG2136	Putative SAM-dependent methyltransferase
B657_21870	COG0129	dihydroxy-acid dehydratase activity
B657_21880	COG1413	lyase activity
B657_21890	COG1418	mRNA catabolic process
B657_21900	COG0386	Belongs to the glutathione peroxidase family
B657_21910	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
B657_21920	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
B657_21930	COG1278	Cold shock
B657_21970	COG0328	RNA-DNA hybrid ribonuclease activity
B657_21980	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
B657_21990	COG0328	RNA-DNA hybrid ribonuclease activity
B657_22010	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B657_22030	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B657_22040	COG1755	Isoprenylcysteine carboxyl methyltransferase
B657_22050	COG3424	synthase
B657_22060	COG2233	PERMEase
B657_22070	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B657_22080	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
B657_22100	COG0800	Aldolase
B657_22110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B657_22130	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
B657_22140	COG1028	Short-chain dehydrogenase reductase Sdr
B657_22150	COG1199	ATP-dependent helicase activity
B657_22170	COG0116	Belongs to the methyltransferase superfamily
B657_22190	COG4474	Belongs to the UPF0398 family
B657_22210	COG3359	exonuclease
B657_22220	COG1111	helicase
B657_22220	COG1205	dead DEAH box helicase
B657_22230	COG2190	(PTS) system
B657_22240	COG0071	Belongs to the small heat shock protein (HSP20) family
B657_22310	COG3331	DNA recombination
B657_22320	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B657_22320	COG4499	WXG100 protein secretion system (Wss), protein YukC
B657_22340	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
B657_22350	COG3935	DnaD domain protein
B657_22360	COG0017	Asparaginyl-tRNA synthetase
B657_22370	COG0436	Aminotransferase
B657_22380	COG5353	protein conserved in bacteria
B657_22400	COG1199	ATP-dependent helicase activity
B657_22400	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
B657_22410	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
B657_22420	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
B657_22430	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
B657_22450	COG0617	tRNA 3'-terminal CCA addition
B657_22460	COG0438	transferase activity, transferring glycosyl groups
B657_22470	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
B657_22480	COG1803	Methylglyoxal synthase
B657_22490	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
B657_22500	COG1694	Mazg nucleotide pyrophosphohydrolase
B657_22510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B657_22530	COG4347	Protein of unknown function (DUF1405)
B657_22540	COG2010	Cytochrome c
B657_22540	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B657_22550	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
B657_22560	COG0723	plastoquinol--plastocyanin reductase activity
B657_22580	COG5582	Belongs to the UPF0302 family
B657_22590	COG0457	Tetratricopeptide repeat
B657_22600	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
B657_22610	COG0287	Prephenate dehydrogenase
B657_22620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
B657_22630	COG0159	tryptophan synthase activity
B657_22640	COG0133	tryptophan synthase activity
B657_22650	COG0135	phosphoribosylanthranilate isomerase activity
B657_22670	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
B657_22680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
B657_22690	COG4401	Chorismate mutase type I
B657_22700	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
B657_22710	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
B657_22720	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
B657_22730	COG0105	UTP biosynthetic process
B657_22740	COG0142	geranyltranstransferase activity
B657_22750	COG2226	methyltransferase
B657_22760	COG0142	geranyltranstransferase activity
B657_22780	COG0302	gtp cyclohydrolase
B657_22790	COG0776	regulation of translation
B657_22800	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
B657_22830	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
B657_22840	COG1160	GTP binding
B657_22870	COG1304	FMN binding
B657_22880	COG0539	negative regulation of cytoplasmic translation
B657_22890	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
B657_22910	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
B657_22920	COG2959	enzyme of heme biosynthesis
B657_22930	COG3773	Cell wall hydrolase
B657_22930	COG3409	Peptidoglycan-binding domain 1 protein
B657_22940	COG2339	peptidase activity
B657_22950	COG0492	ferredoxin-NADP+ reductase activity
B657_22960	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B657_22970	COG4862	establishment of competence for transformation
B657_22980	COG1408	metallophosphoesterase
B657_23000	COG1388	LysM domain
B657_23010	COG1266	CAAX protease self-immunity
B657_23020	COG0514	ATP-dependent DNA helicase (RecQ)
B657_23030	COG4955	Helix-turn-helix domain
B657_23040	COG1141	Ferredoxin
B657_23050	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
B657_23070	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
B657_23080	COG0710	3-dehydroquinate dehydratase activity
B657_23100	COG1595	DNA-templated transcription, initiation
B657_23110	COG5002	protein histidine kinase activity
B657_23120	COG0745	RESPONSE REGULATOR receiver
B657_23130	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B657_23140	COG1333	cytochrome c biogenesis protein
B657_23150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B657_23160	COG1187	pseudouridine synthase activity
B657_23170	COG0700	Nucleoside recognition
B657_23180	COG2715	membrane protein required for spore maturation
B657_23190	COG1686	Belongs to the peptidase S11 family
B657_23210	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
B657_23220	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
B657_23230	COG1547	Domain of unknown function (DUF309)
B657_23240	COG0456	acetyltransferase
B657_23250	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
B657_23260	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B657_23260	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
B657_23270	COG0307	riboflavin synthase, alpha
B657_23280	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B657_23280	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
B657_23310	COG0681	Belongs to the peptidase S26 family
B657_23328	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
B657_23360	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
B657_23370	COG4086	secreted protein
B657_23380	COG0019	diaminopimelate decarboxylase activity
B657_23390	COG0697	spore germination
B657_23410	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
B657_23450	COG1191	sigma factor activity
B657_23460	COG2172	sigma factor antagonist activity
B657_23470	COG1366	Belongs to the anti-sigma-factor antagonist family
B657_23480	COG1686	Belongs to the peptidase S11 family
B657_23490	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
B657_23500	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
B657_23510	COG4974	Belongs to the 'phage' integrase family
B657_23520	COG0735	belongs to the Fur family
B657_23530	COG1300	Membrane
B657_23550	COG0281	malic enzyme
B657_23560	COG1757	Na H antiporter
B657_23570	COG1027	Aspartate ammonia-lyase
B657_23580	COG0252	asparaginase activity
B657_23590	COG1396	sequence-specific DNA binding
B657_23600	COG1379	DNA repair
B657_23610	COG0494	nUDIX hydrolase
B657_23620	COG0667	Aldo Keto reductase
B657_23640	COG1073	alpha beta
B657_23660	COG4918	Iron-sulphur cluster biosynthesis
B657_23670	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
B657_23670	COG0456	acetyltransferase
B657_23680	COG2329	Antibiotic biosynthesis monooxygenase
B657_23690	COG0456	acetyltransferase
B657_23710	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B657_23730	COG2211	Major facilitator Superfamily
B657_23750	COG0346	lactoylglutathione lyase activity
B657_23760	COG1072	(Pantothenic acid kinase))
B657_23770	COG3048	D-serine ammonia-lyase activity
B657_23780	COG0300	oxidoreductase activity
B657_23790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B657_23800	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
B657_23810	COG4187	Peptidase family M20/M25/M40
B657_23820	COG1902	pentaerythritol trinitrate reductase activity
B657_23830	COG0596	Alpha beta hydrolase
B657_23840	COG1234	tRNA 3'-trailer cleavage
B657_23850	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
B657_23860	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B657_23870	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
B657_23890	COG0706	membrane insertase activity
B657_23900	COG3361	conserved protein (COG2071)
B657_23910	COG2195	Cleaves the N-terminal amino acid of tripeptides
B657_23920	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
B657_23930	COG0346	lactoylglutathione lyase activity
B657_23940	COG1376	ErfK ybiS ycfS ynhG family protein
B657_23950	COG4129	membrane
B657_23960	COG1126	abc transporter atp-binding protein
B657_23970	COG0765	amino acid transport
B657_23980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B657_24000	COG1597	lipid kinase activity
B657_24010	COG2814	Major facilitator Superfamily
B657_24020	COG0789	Transcriptional regulator
B657_24020	COG4978	Transcriptional regulator
B657_24030	COG0508	dehydrogenase complex catalyzes the overall conversion of
B657_24040	COG0022	dehydrogenase e1 component
B657_24050	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
B657_24060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
B657_24070	COG3426	butyrate kinase activity
B657_24080	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B657_24090	COG0280	phosphate acetyltransferase
B657_24100	COG3290	protein histidine kinase activity
B657_24100	COG3829	transcription factor binding
B657_24120	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
B657_24130	COG2079	MmgE PrpD family protein
B657_24140	COG0372	Belongs to the citrate synthase family
B657_24150	COG1960	acyl-CoA dehydrogenase activity
B657_24160	COG1250	3-hydroxyacyl-CoA dehydrogenase
B657_24170	COG0183	Belongs to the thiolase family
B657_24180	COG0584	glycerophosphoryl diester phosphodiesterase
B657_24190	COG0860	N-Acetylmuramoyl-L-alanine amidase
B657_24210	COG1902	pentaerythritol trinitrate reductase activity
B657_24220	COG0745	RESPONSE REGULATOR receiver
B657_24230	COG0750	zinc metalloprotease
B657_24240	COG0497	DNA recombination
B657_24250	COG1438	arginine binding
B657_24260	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
B657_24270	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
B657_24280	COG0142	geranyltranstransferase activity
B657_24290	COG1722	exodeoxyribonuclease VII activity
B657_24300	COG1570	exodeoxyribonuclease VII activity
B657_24310	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
B657_24320	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
B657_24330	COG1302	Protein conserved in bacteria
B657_24340	COG0439	Biotin carboxylase
B657_24350	COG0511	ligase activity, forming carbon-carbon bonds
B657_24430	COG3854	ATPases associated with a variety of cellular activities
B657_24450	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
B657_24460	COG0006	proline dipeptidase activity
B657_24470	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
B657_24490	COG3872	metal-dependent enzyme
B657_24510	COG1752	Esterase of the alpha-beta hydrolase superfamily
B657_24520	COG1321	iron dependent repressor
B657_24530	COG0095	Lipoate-protein ligase
B657_24540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B657_24550	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B657_24560	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
B657_24570	COG0404	The glycine cleavage system catalyzes the degradation of glycine
B657_24580	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B657_24610	COG1396	sequence-specific DNA binding
B657_24630	COG0681	Belongs to the peptidase S26 family
B657_24680	COG4940	Competence protein ComGF
B657_24700	COG4970	Tfp pilus assembly protein FimT
B657_24710	COG4537	Required for transformation and DNA binding
B657_24720	COG1459	type II secretion system
B657_24730	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
B657_24740	COG0598	Magnesium transport protein CorA
B657_24750	COG1253	flavin adenine dinucleotide binding
B657_24760	COG1366	Belongs to the anti-sigma-factor antagonist family
B657_24770	COG1393	Belongs to the ArsC family
B657_24790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B657_24810	COG0011	TIGRFAM Protein of
B657_24830	COG2866	Carboxypeptidase
B657_24840	COG1368	sulfuric ester hydrolase activity
B657_24850	COG1940	carbohydrate kinase activity
B657_24860	COG4483	Protein conserved in bacteria
B657_24870	COG0705	Rhomboid family
B657_24870	COG0457	Tetratricopeptide repeat
B657_24890	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
B657_24910	COG0438	transferase activity, transferring glycosyl groups
B657_24940	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B657_24950	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B657_24960	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
B657_24970	COG0581	inorganic phosphate transmembrane transporter activity
B657_24980	COG0573	inorganic phosphate transmembrane transporter activity
B657_24990	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
B657_25010	COG0477	Major facilitator Superfamily
B657_25020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
B657_25030	COG2839	Protein conserved in bacteria
B657_25040	COG5521	maltodextrose utilization protein MalA
B657_25060	COG1388	LysM domain
B657_25070	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
B657_25080	COG4709	membrane
B657_25090	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
B657_25100	COG0735	belongs to the Fur family
B657_25110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B657_25130	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
B657_25140	COG0513	Belongs to the DEAD box helicase family
B657_25160	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
B657_25170	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
B657_25180	COG2384	SAM-dependent methyltransferase
B657_25190	COG2010	Cytochrome c
B657_25200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
B657_25210	COG0358	DNA primase activity
B657_25230	COG1671	Belongs to the UPF0178 family
B657_25240	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
B657_25250	COG0517	IMP dehydrogenase activity
B657_25260	COG0751	glycine-tRNA ligase activity
B657_25270	COG0752	glycyl-tRNA synthetase alpha subunit
B657_25280	COG1381	Involved in DNA repair and RecF pathway recombination
B657_25290	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
B657_25300	COG0295	cytidine deaminase activity
B657_26410	COG3223	Belongs to the PsiE family
B657_26420	COG0642	Histidine kinase
B657_26420	COG5002	protein histidine kinase activity
B657_26430	COG0745	RESPONSE REGULATOR receiver
B657_26440	COG2311	Membrane
B657_26450	COG0454	-acetyltransferase
B657_26470	COG2249	NAD(P)H dehydrogenase (quinone) activity
B657_26490	COG0730	response to heat
B657_26500	COG0425	Belongs to the sulfur carrier protein TusA family
B657_26510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B657_26510	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B657_26530	COG0425	Belongs to the sulfur carrier protein TusA family
B657_26530	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B657_26540	COG2210	Belongs to the sulfur carrier protein TusA family
B657_26550	COG1937	Protein conserved in bacteria
B657_26560	COG0662	Cupin 2, conserved barrel domain protein
B657_26580	COG0789	Transcriptional regulator
B657_26580	COG4978	Transcriptional regulator
B657_26590	COG2814	Major facilitator Superfamily
B657_26600	COG0456	acetyltransferase
B657_26610	COG1253	flavin adenine dinucleotide binding
B657_26620	COG0697	spore germination
B657_26630	COG0583	DNA-binding transcription factor activity
B657_26640	COG2072	flavoprotein involved in K transport
B657_26650	COG1230	cation diffusion facilitator family transporter
B657_26660	COG1942	4-Oxalocrotonate Tautomerase
B657_26670	COG0583	DNA-binding transcription factor activity
B657_26690	COG1114	Component of the transport system for branched-chain amino acids
B657_26700	COG1687	branched-chain amino acid
B657_26710	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
B657_26720	COG1522	sequence-specific DNA binding
B657_26730	COG2732	(Barnase) inhibitor
B657_26740	COG2124	cytochrome p450
B657_26760	COG1335	isochorismatase
B657_26780	COG2318	DinB family
B657_26800	COG2070	2-Nitropropane dioxygenase
B657_26810	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B657_26830	COG3443	Belongs to the bacterial solute-binding protein 9 family
B657_26840	COG1595	DNA-templated transcription, initiation
B657_26850	COG0667	Aldo Keto reductase
B657_26860	COG2851	Citrate transporter
B657_26870	COG0583	DNA-binding transcription factor activity
B657_26880	COG2828	Protein conserved in bacteria
B657_26890	COG3409	Peptidoglycan-binding domain 1 protein
B657_26900	COG5566	PFAM Mor transcription activator
B657_26910	COG0596	Alpha beta hydrolase
B657_26920	COG4991	sh3 domain protein
B657_26930	COG4991	sh3 domain protein
B657_26940	COG0346	lactoylglutathione lyase activity
B657_26960	COG5577	PFAM Coat F domain
B657_26970	COG1063	alcohol dehydrogenase
B657_26990	COG5577	PFAM Coat F domain
B657_27000	COG0789	Transcriptional regulator
B657_27010	COG1064	alcohol dehydrogenase
B657_27020	COG0693	protein deglycase activity
B657_27030	COG1621	beta-fructofuranosidase activity
B657_27040	COG3716	PTS system mannose fructose sorbose family IID component
B657_27050	COG3715	PTS system
B657_27060	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B657_27070	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
B657_27080	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
B657_27080	COG3933	PFAM sigma-54 factor interaction domain-containing protein
B657_27090	COG1113	amino acid transport
B657_27100	COG1280	lysine exporter protein (LysE YggA)
B657_27110	COG1378	Sugar-specific transcriptional regulator TrmB
B657_27120	COG1595	DNA-templated transcription, initiation
B657_27140	COG2755	lipolytic protein G-D-S-L family
B657_27140	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
B657_27160	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B657_27160	COG2124	cytochrome p450
B657_27170	COG1309	transcriptional regulator
B657_27180	COG2226	methyltransferase
B657_27200	COG2116	formate transmembrane transporter activity
B657_27210	COG5609	conserved protein (DUF2294)
B657_27220	COG3383	formate dehydrogenase (NAD+) activity
B657_27230	COG2427	Protein of unknown function (DUF1641)
B657_27250	COG0626	cystathionine gamma-synthase activity
B657_27260	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B657_27270	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
B657_27280	COG2226	methyltransferase
B657_27310	COG0768	penicillin binding
B657_27320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
B657_27330	COG0572	uridine kinase
B657_27370	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
B657_27380	COG3906	Belongs to the UPF0473 family
B657_27390	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
B657_27400	COG4472	Bacterial protein of unknown function (DUF965)
B657_27410	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
B657_27420	COG0628	permease
B657_27430	COG1126	abc transporter atp-binding protein
B657_27440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B657_27450	COG0765	amino acid transport
B657_27460	COG0765	amino acid transport
B657_27470	COG3881	PFAM PRC-barrel domain
B657_27480	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
B657_27490	COG0457	Tetratricopeptide repeat
B657_27500	COG0482	sulfurtransferase activity
B657_27510	COG1104	cysteine desulfurase activity
B657_27520	COG1959	2 iron, 2 sulfur cluster binding
B657_27530	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
B657_27540	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
B657_27550	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
B657_27560	COG0124	histidyl-tRNA synthetase
B657_27580	COG4991	sh3 domain protein
B657_27580	COG0860	N-Acetylmuramoyl-L-alanine amidase
B657_27580	COG3103	Sh3 type 3 domain protein
B657_27590	COG1490	D-aminoacyl-tRNA deacylase activity
B657_27600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
B657_27610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
B657_27620	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
B657_27620	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
B657_27630	COG5416	Lipopolysaccharide assembly protein A domain
B657_27640	COG0490	domain, Protein
B657_27650	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B657_27650	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
B657_27670	COG2244	polysaccharide biosynthetic process
B657_27680	COG2323	membrane
B657_27700	COG1862	Preprotein translocase
B657_27710	COG0343	queuine tRNA-ribosyltransferase activity
B657_27720	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
B657_27730	COG2255	four-way junction helicase activity
B657_27740	COG0632	four-way junction helicase activity
B657_27760	COG2814	Major facilitator Superfamily
B657_27770	COG0673	inositol 2-dehydrogenase activity
B657_27785	COG2112	serine threonine protein kinase
B657_27810	COG1115	amino acid carrier protein
B657_27820	COG0217	transcriptional regulatory protein
B657_27840	COG1388	LysM domain
B657_27850	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
B657_27860	COG0157	Belongs to the NadC ModD family
B657_27870	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
B657_27880	COG1104	cysteine desulfurase activity
B657_27890	COG1827	regulation of RNA biosynthetic process
B657_27900	COG0077	Prephenate dehydratase
B657_27910	COG4492	Belongs to the UPF0735 family
B657_27920	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
B657_27930	COG3290	protein histidine kinase activity
B657_27940	COG0211	Belongs to the bacterial ribosomal protein bL27 family
B657_27950	COG2868	ribosomal protein
B657_27960	COG0261	This protein binds to 23S rRNA in the presence of protein L20
B657_27970	COG1994	Peptidase M50
B657_27980	COG0739	heme binding
B657_27990	COG2894	cell division
B657_28000	COG0850	regulation of cytokinetic process
B657_28010	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
B657_28020	COG1792	Involved in formation and maintenance of cell shape
B657_28030	COG1077	Cell shape determining protein MreB Mrl
B657_28040	COG2003	Belongs to the UPF0758 family
B657_28050	COG0424	maF-like protein
B657_28070	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
B657_28080	COG0285	dihydrofolate synthase activity
B657_28090	COG0525	valine-tRNA ligase activity
B657_28100	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B657_28110	COG1388	LysM domain
B657_28120	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
B657_28130	COG0113	porphobilinogen synthase activity
B657_28140	COG1587	Uroporphyrinogen-III synthase
B657_28150	COG0181	hydroxymethylbilane synthase activity
B657_28160	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
B657_28170	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
B657_28190	COG0218	Necessary for normal cell division and for the maintenance of normal septation
B657_28200	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
B657_28210	COG1067	ATP-dependent peptidase activity
B657_28210	COG0470	DNA polymerase III
B657_28220	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
B657_28230	COG0544	peptidyl-prolyl cis-trans isomerase activity
B657_28240	COG0457	Tetratricopeptide repeat
B657_28240	COG1477	protein flavinylation
B657_28250	COG0066	3-isopropylmalate dehydratase activity
B657_28260	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
B657_28270	COG0473	3-isopropylmalate dehydrogenase activity
B657_28280	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
B657_28290	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
B657_28300	COG0440	acetolactate synthase activity
B657_28310	COG0028	Belongs to the TPP enzyme family
B657_28330	COG0454	-acetyltransferase
B657_28340	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
B657_28350	COG0622	Phosphoesterase
B657_28360	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
B657_28370	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
B657_28380	COG5401	PFAM Sporulation and spore germination
B657_28390	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
B657_28400	COG1846	Transcriptional regulator
B657_28410	COG2197	response regulator
B657_28420	COG0824	Thioesterase
B657_28430	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
B657_28440	COG1053	succinate dehydrogenase
B657_28450	COG2009	succinate dehydrogenase
B657_28460	COG1719	4-vinyl reductase, 4VR
B657_28470	COG0527	aspartate kinase activity
B657_28490	COG0322	excinuclease ABC activity
B657_28500	COG3118	belongs to the thioredoxin family
B657_28510	COG3534	alpha-L-arabinofuranosidase
B657_28520	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
B657_28530	COG2086	electron transfer activity
B657_28540	COG1024	Enoyl-CoA hydratase
B657_28550	COG1309	transcriptional regulator
B657_28560	COG0318	PFAM AMP-dependent synthetase and ligase
B657_28570	COG3766	membrane
B657_28580	COG1193	negative regulation of DNA recombination
B657_28590	COG1796	DNA polymerase
B657_28590	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B657_28600	COG1286	toxin biosynthetic process
B657_28610	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
B657_28620	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
B657_28630	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B657_28630	COG0072	phenylalanine-tRNA ligase activity
B657_28640	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
B657_28650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
B657_28670	COG3835	regulator
B657_28680	COG0277	FAD linked oxidase domain protein
B657_28690	COG0247	lactate metabolic process
B657_28700	COG0346	lactoylglutathione lyase activity
B657_28710	COG1966	Carbon starvation protein
B657_28720	COG3534	alpha-L-arabinofuranosidase
B657_28730	COG0395	ABC-type sugar transport system, permease component
B657_28740	COG1175	transmembrane transport
B657_28750	COG1653	transport
B657_28760	COG0371	Dehydrogenase
B657_28770	COG0647	UMP catabolic process
B657_28780	COG0235	Class ii aldolase
B657_28790	COG1069	ribulokinase activity
B657_28800	COG2160	L-arabinose isomerase activity
B657_28810	COG3507	Belongs to the glycosyl hydrolase 43 family
B657_28820	COG1363	Peptidase, m42
B657_28840	COG3326	Membrane
B657_28850	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
B657_28860	COG0291	Belongs to the bacterial ribosomal protein bL35 family
B657_28870	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
B657_28900	COG1346	cytolysis
B657_28910	COG1380	Effector of murein hydrolase LrgA
B657_28920	COG3279	Response regulator of the LytR AlgR family
B657_28930	COG3275	phosphorelay sensor kinase activity
B657_28950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B657_28970	COG0398	Pfam SNARE associated Golgi protein
B657_28980	COG1484	DNA-dependent DNA replication
B657_28990	COG3611	Membrane attachment protein
B657_29000	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
B657_29010	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
B657_29020	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B657_29030	COG1733	regulation of RNA biosynthetic process
B657_29040	COG2814	Major facilitator Superfamily
B657_29050	COG0656	L-ascorbic acid biosynthetic process
B657_29060	COG0237	dephospho-CoA kinase activity
B657_29070	COG1971	Probably functions as a manganese efflux pump
B657_29080	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
B657_29090	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B657_29090	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
B657_29100	COG5002	protein histidine kinase activity
B657_29110	COG0745	RESPONSE REGULATOR receiver
B657_29120	COG0039	L-malate dehydrogenase activity
B657_29130	COG0538	isocitrate dehydrogenase activity
B657_29140	COG0372	Belongs to the citrate synthase family
B657_29150	COG2707	UPF0756 membrane protein
B657_29160	COG0628	permease
B657_29170	COG3030	protein affecting phage T7 exclusion by the F plasmid
B657_29180	COG0469	pyruvate kinase activity
B657_29190	COG0205	6-phosphofructokinase activity
B657_29200	COG0825	malonyl-CoA metabolic process
B657_29210	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
B657_29220	COG0281	malic enzyme
B657_29230	COG0587	DNA-directed DNA polymerase activity
B657_29250	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
B657_29270	COG4109	DRTGG domain
B657_29280	COG0730	response to heat
B657_29290	COG1473	amidohydrolase
B657_29300	COG0196	riboflavin kinase activity
B657_29310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B657_29320	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
B657_29330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B657_29340	COG1126	abc transporter atp-binding protein
B657_29350	COG0765	amino acid transport
B657_29360	COG0765	amino acid transport
B657_29370	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B657_29380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B657_29390	COG0454	-acetyltransferase
B657_29400	COG0583	DNA-binding transcription factor activity
B657_29410	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
B657_29420	COG1028	Short-chain dehydrogenase reductase Sdr
B657_29440	COG0165	Argininosuccinate lyase
B657_29450	COG0137	argininosuccinate synthase activity
B657_29460	COG0521	Mo-molybdopterin cofactor biosynthetic process
B657_29470	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
B657_29480	COG0827	DNA restriction-modification system
B657_29490	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
B657_29500	COG3874	Sporulation protein YtfJ
B657_29520	COG1714	RDD family
B657_29530	COG0616	signal peptide processing
B657_29540	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
B657_29550	COG1574	metal-dependent hydrolase with the TIM-barrel fold
B657_29560	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B657_29580	COG0301	tRNA thio-modification
B657_29590	COG1104	cysteine desulfurase activity
B657_29600	COG1114	Component of the transport system for branched-chain amino acids
B657_29610	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
B657_29620	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
B657_29630	COG1309	transcriptional regulator
B657_29640	COG1956	GAF domain-containing protein
B657_29650	COG2203	Gaf domain
B657_29650	COG2199	diguanylate cyclase activity
B657_29660	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
B657_29670	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B657_29680	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
B657_29690	COG0454	-acetyltransferase
B657_29700	COG0517	IMP dehydrogenase activity
B657_29710	COG0123	including yeast histone deacetylase and acetoin utilization protein
B657_29720	COG1360	Flagellar Motor Protein
B657_29730	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
B657_29740	COG1609	Transcriptional regulator
B657_29750	COG1605	Chorismate mutase
B657_29750	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
B657_29760	COG3118	belongs to the thioredoxin family
B657_29770	COG4980	gas vesicle protein
B657_29780	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
B657_29790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
B657_29805	COG1674	ftsk spoiiie
B657_29820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
B657_29830	COG4848	Belongs to the UPF0354 family
B657_29840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B657_29860	COG1363	Peptidase, m42
B657_29870	COG5584	Small secreted protein
B657_29880	COG0281	malic enzyme
B657_29890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B657_29900	COG0220	tRNA (guanine-N7-)-methyltransferase activity
B657_29920	COG0510	thiamine kinase activity
B657_29930	COG1523	belongs to the glycosyl hydrolase 13 family
B657_29940	COG1597	lipid kinase activity
B657_29960	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
B657_29970	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
B657_29980	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B657_29990	COG2252	PERMEase
B657_30000	COG4473	ABC transporter
B657_30010	COG1131	(ABC) transporter
B657_30020	COG1349	DNA-binding transcription factor activity
B657_30035	COG1187	pseudouridine synthase activity
B657_30050	COG2244	polysaccharide biosynthetic process
B657_30060	COG2081	HI0933 family
B657_30070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
B657_30090	COG5578	integral membrane protein
B657_30100	COG0673	inositol 2-dehydrogenase activity
B657_30110	COG1653	transport
B657_30120	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
B657_30135	COG4209	transmembrane transport
B657_30150	COG2207	Transcriptional regulator
B657_30160	COG1653	transport
B657_30170	COG0395	ABC-type sugar transport system, permease component
B657_30180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B657_30190	COG2124	cytochrome p450
B657_30200	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
B657_30210	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
B657_30220	COG0156	8-amino-7-oxononanoate synthase activity
B657_30230	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
B657_30240	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
B657_30250	COG1073	alpha beta
B657_30300	COG1486	melibiose metabolic process
B657_30310	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
B657_30320	COG0495	leucyl-tRNA aminoacylation
B657_30340	COG2202	Pas domain
B657_30340	COG1366	Belongs to the anti-sigma-factor antagonist family
B657_30350	COG2814	Major facilitator Superfamily
B657_30360	COG2433	Pfam Transposase IS66
B657_30370	COG0577	efflux transmembrane transporter activity
B657_30380	COG1136	(ABC) transporter
B657_30390	COG2205	protein histidine kinase activity
B657_30400	COG0745	RESPONSE REGULATOR receiver
B657_30410	COG0577	efflux transmembrane transporter activity
B657_30420	COG1136	(ABC) transporter
B657_30450	COG1131	(ABC) transporter
B657_30460	COG1725	Transcriptional regulator
B657_30480	COG1242	4 iron, 4 sulfur cluster binding
B657_30490	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
B657_30510	COG2267	carboxylic ester hydrolase activity
B657_30520	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
B657_30530	COG1113	amino acid transport
B657_30540	COG0367	asparagine synthase
B657_30550	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
B657_30560	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
B657_30580	COG1506	peptidase
B657_30595	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
B657_30610	COG1116	anion transmembrane transporter activity
B657_30620	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
B657_30630	COG0494	nUDIX hydrolase
B657_30640	COG4824	toxin secretion phage lysis holin
B657_30650	COG0783	Belongs to the Dps family
B657_30670	COG1854	S-ribosylhomocysteine lyase activity
B657_30680	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
B657_30690	COG0288	reversible hydration of carbon dioxide
B657_30700	COG0254	rRNA binding
B657_30710	COG1271	oxidase subunit
B657_30720	COG1294	oxidase, subunit
B657_30740	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B657_30750	COG1321	iron dependent repressor
B657_30750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
B657_30760	COG1121	(ABC) transporter
B657_30770	COG0803	Belongs to the bacterial solute-binding protein 9 family
B657_30780	COG4948	Mandelate Racemase Muconate Lactonizing
B657_30790	COG0318	PFAM AMP-dependent synthetase and ligase
B657_30800	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
B657_30810	COG0596	Alpha beta hydrolase
B657_30820	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
B657_30830	COG1169	isochorismate synthase
B657_30840	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
B657_30850	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B657_30860	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B657_30870	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
B657_30880	COG0438	transferase activity, transferring glycosyl groups
B657_30900	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B657_30910	COG0438	transferase activity, transferring glycosyl groups
B657_30920	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B657_30930	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
B657_30940	COG0058	SHG alpha-glucan phosphorylase activity
B657_30950	COG0297	glycogen (starch) synthase activity
B657_30960	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B657_30970	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
B657_30980	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
B657_30990	COG3859	Proton-coupled thiamine transporter YuaJ
B657_31000	COG1247	-acetyltransferase
B657_31010	COG2268	Band 7 protein
B657_31020	COG1585	Membrane protein implicated in regulation of membrane protease activity
B657_31030	COG2318	DinB family
B657_31050	COG1454	alcohol dehydrogenase
B657_31070	COG1510	regulation of RNA biosynthetic process
B657_31090	COG0569	domain protein
B657_31100	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
B657_31110	COG4682	membrane
B657_31120	COG1705	Flagellar rod assembly protein muramidase FlgJ
B657_31130	COG0477	Major facilitator Superfamily
B657_31140	COG5553	Cysteine dioxygenase type I
B657_31150	COG1968	undecaprenyl-diphosphatase activity
B657_31160	COG0628	permease
B657_31170	COG0673	inositol 2-dehydrogenase activity
B657_31180	COG4806	L-rhamnose isomerase
B657_31190	COG3254	rhamnose metabolic process
B657_31200	COG1070	Carbohydrate kinase
B657_31210	COG1349	DNA-binding transcription factor activity
B657_31220	COG3347	Dehydrogenase
B657_31220	COG1028	Short-chain dehydrogenase reductase Sdr
B657_31230	COG0840	transmembrane signaling receptor activity
B657_31240	COG0840	transmembrane signaling receptor activity
B657_31250	COG0840	transmembrane signaling receptor activity
B657_31260	COG0840	transmembrane signaling receptor activity
B657_31280	COG0432	Pfam Uncharacterised protein family UPF0047
B657_31290	COG0366	Alpha amylase catalytic
B657_31300	COG1253	flavin adenine dinucleotide binding
B657_31310	COG2738	Putative neutral zinc metallopeptidase
B657_31322	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
B657_31350	COG0166	Belongs to the GPI family
B657_31360	COG1979	alcohol dehydrogenase
B657_31370	COG1979	alcohol dehydrogenase
B657_31380	COG2155	Conserved Protein
B657_31390	COG1098	S1 RNA binding domain
B657_31400	COG0436	Aminotransferase
B657_31410	COG1522	sequence-specific DNA binding
B657_31420	COG2267	carboxylic ester hydrolase activity
B657_31440	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
B657_31450	COG2205	protein histidine kinase activity
B657_31470	COG5018	Exonuclease
B657_31480	COG2814	Major facilitator Superfamily
B657_31490	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B657_31500	COG3011	Protein conserved in bacteria
B657_31520	COG3290	protein histidine kinase activity
B657_31530	COG4565	transcriptional regulatory protein
B657_31580	COG3493	citrate carrier protein
B657_31600	COG2111	Na H antiporter
B657_31600	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
B657_31610	COG2111	Na H antiporter
B657_31620	COG1006	Multisubunit Na H antiporter MnhC subunit
B657_31630	COG0651	ATP synthesis coupled electron transport
B657_31640	COG1863	multisubunit Na H antiporter MnhE subunit
B657_31650	COG2212	antiporter activity
B657_31660	COG1320	monovalent cation:proton antiporter activity
B657_31670	COG2050	protein possibly involved in aromatic compounds catabolism
B657_31680	COG2197	response regulator
B657_31690	COG4585	Histidine kinase
B657_31710	COG0142	geranyltranstransferase activity
B657_31740	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
B657_31750	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
B657_31760	COG1335	isochorismatase
B657_31770	COG5506	Protein of unknown function (DUF1694)
B657_31800	COG0628	permease
B657_31830	COG1418	mRNA catabolic process
B657_31840	COG1028	Short-chain dehydrogenase reductase Sdr
B657_31860	COG1511	domain protein
B657_31875	COG1674	ftsk spoiiie
B657_31875	COG0433	COG0433 Predicted ATPase
B657_31890	COG4499	WXG100 protein secretion system (Wss), protein YukC
B657_31900	COG5417	Belongs to the EsaB family
B657_31910	COG4842	Belongs to the WXG100 family
B657_31920	COG2508	Transcriptional regulator
B657_31920	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
B657_31930	COG0686	Belongs to the AlaDH PNT family
B657_31945	COG5634	Uncharacterized conserved protein (DUF2278)
B657_31959	COG3251	PFAM MbtH domain protein
B657_31960	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B657_31970	COG3433	isochorismatase activity
B657_31970	COG1535	isochorismatase
B657_31980	COG1021	2,3-dihydroxybenzoate-AMP ligase
B657_31990	COG1169	isochorismate synthase
B657_32000	COG1028	Short-chain dehydrogenase reductase Sdr
B657_32010	COG2819	hydrolase of the alpha beta superfamily
B657_32020	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
B657_32030	COG1268	BioY protein
B657_32040	COG2056	Na+-H+ antiporter family
B657_32050	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
B657_32060	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
B657_32070	COG3584	3D domain protein
B657_32100	COG1252	NADH dehydrogenase
B657_32110	COG0492	ferredoxin-NADP+ reductase activity
B657_32130	COG0516	GMP reductase activity
B657_32140	COG2808	Putative FMN-binding domain
B657_32150	COG0456	acetyltransferase
B657_32160	COG0316	Belongs to the HesB IscA family
B657_32170	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
B657_32180	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B657_32190	COG4844	belongs to the
B657_32200	COG1252	NADH dehydrogenase
B657_32210	COG4837	Protein of unknown function (DUF1462)
B657_32220	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
B657_32230	COG4946	Tricorn protease homolog
B657_32230	COG1506	peptidase
B657_32230	COG0823	Involved in the tonB-independent uptake of proteins
B657_32240	COG0083	homoserine kinase activity
B657_32250	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
B657_32260	COG0460	homoserine dehydrogenase
B657_32270	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
B657_32280	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
B657_32290	COG0647	UMP catabolic process
B657_32300	COG2445	Protein of unknown function DUF86
B657_32310	COG4470	Protein conserved in bacteria
B657_32330	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
B657_32340	COG0739	heme binding
B657_32360	COG3377	Domain of unknown function (DUF1805)
B657_32370	COG0737	Belongs to the 5'-nucleotidase family
B657_32380	COG0730	response to heat
B657_32390	COG1801	Protein of unknown function DUF72
B657_32410	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
B657_32420	COG2508	Transcriptional regulator
B657_32430	COG2233	PERMEase
B657_32440	COG2233	PERMEase
B657_32450	COG3648	Uricase
B657_32450	COG3195	allantoin biosynthetic process
B657_32460	COG2351	hydroxyisourate hydrolase activity
B657_32470	COG2080	2 iron, 2 sulfur cluster binding
B657_32480	COG1529	Aldehyde oxidase and xanthine dehydrogenase
B657_32490	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
B657_32500	COG2068	MobA-Related Protein
B657_32510	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
B657_32520	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
B657_32530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
B657_32540	COG2356	endonuclease I
B657_32550	COG3842	ATPase activity
B657_32560	COG2188	Transcriptional regulator
B657_32570	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B657_32580	COG0395	ABC-type sugar transport system, permease component
B657_32590	COG1175	transmembrane transport
B657_32600	COG1653	transport
B657_32610	COG2222	sugar isomerase
B657_32620	COG0322	excinuclease ABC activity
B657_32630	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
B657_32660	COG0346	lactoylglutathione lyase activity
B657_32669	COG0640	Transcriptional regulator
B657_32670	COG0719	Fe-S assembly protein
B657_32680	COG0822	iron-sulfur transferase activity
B657_32690	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
B657_32700	COG0719	Fe-S assembly protein
B657_32710	COG0396	ATPase activity
B657_32720	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
B657_32730	COG1464	Belongs to the NlpA lipoprotein family
B657_32740	COG2011	ABC-type metal ion transport system permease component
B657_32750	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
B657_32770	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
B657_32780	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
B657_32800	COG0509	glycine decarboxylation via glycine cleavage system
B657_32810	COG1393	Belongs to the ArsC family
B657_32820	COG1960	acyl-CoA dehydrogenase activity
B657_32830	COG0183	Belongs to the thiolase family
B657_32840	COG1250	3-hydroxyacyl-CoA dehydrogenase
B657_32840	COG1024	Enoyl-CoA hydratase
B657_32850	COG0506	proline dehydrogenase activity
B657_32860	COG5577	PFAM Coat F domain
B657_32870	COG1846	Transcriptional regulator
B657_32880	COG0477	Major facilitator Superfamily
B657_32890	COG1942	4-Oxalocrotonate Tautomerase
B657_32900	COG1028	Short-chain dehydrogenase reductase Sdr
B657_32910	COG1028	Short-chain dehydrogenase reductase Sdr
B657_32920	COG0583	DNA-binding transcription factor activity
B657_32940	COG1120	ATPase activity
B657_32980	COG1028	Short-chain dehydrogenase reductase Sdr
B657_32990	COG0783	Belongs to the Dps family
B657_33000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B657_33010	COG0745	RESPONSE REGULATOR receiver
B657_33020	COG2205	protein histidine kinase activity
B657_33020	COG2770	Histidine kinase
B657_33030	COG1309	transcriptional regulator
B657_33040	COG0114	fumarate hydratase activity
B657_33050	COG0697	spore germination
B657_33060	COG0814	amino acid
B657_33080	COG2197	response regulator
B657_33090	COG4585	Histidine kinase
B657_33100	COG4758	membrane
B657_33110	COG3595	metallopeptidase activity
B657_33120	COG1842	Phage shock protein A
B657_33130	COG4758	membrane
B657_33140	COG2814	Major facilitator Superfamily
B657_33150	COG2096	Adenosyltransferase
B657_33160	COG1120	ATPase activity
B657_33170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B657_33180	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B657_33190	COG1028	Short-chain dehydrogenase reductase Sdr
B657_33200	COG3386	PFAM SMP-30 Gluconolaconase
B657_33210	COG2205	protein histidine kinase activity
B657_33221	COG0745	RESPONSE REGULATOR receiver
B657_33230	COG1191	sigma factor activity
B657_33240	COG2140	Oxalate decarboxylase
B657_33260	COG0577	efflux transmembrane transporter activity
B657_33270	COG1136	(ABC) transporter
B657_33280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
B657_33290	COG1120	ATPase activity
B657_33300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B657_33310	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
B657_33320	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B657_33330	COG0531	amino acid
B657_33350	COG1988	membrane-bound metal-dependent
B657_33360	COG1368	sulfuric ester hydrolase activity
B657_33370	COG1910	domain protein
B657_33380	COG0725	ABC transporter, periplasmic molybdate-binding protein
B657_33390	COG4149	molybdate abc transporter
B657_33400	COG0656	L-ascorbic acid biosynthetic process
B657_33420	COG0025	NhaP-type Na H and K H
B657_33430	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
B657_33440	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
B657_33450	COG3973	AAA domain
B657_33460	COG2860	membrane
B657_33470	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
B657_33480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
B657_33490	COG2217	Heavy metal translocating P-type atpase
B657_33500	COG2217	Heavy metal translocating P-type atpase
B657_33510	COG2608	mercury ion transmembrane transporter activity
B657_33520	COG1937	Protein conserved in bacteria
B657_33530	COG0673	inositol 2-dehydrogenase activity
B657_33540	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
B657_33550	COG1289	transmembrane transporter activity
B657_33570	COG2076	Multidrug Resistance protein
B657_33580	COG1309	transcriptional regulator
B657_33590	COG1028	Short-chain dehydrogenase reductase Sdr
B657_33600	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
B657_33610	COG0557	exoribonuclease II activity
B657_33620	COG1647	Serine aminopeptidase, S33
B657_33630	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
B657_33640	COG0596	Alpha beta hydrolase
B657_33650	COG1476	TRANSCRIPTIONal
B657_33660	COG1396	sequence-specific DNA binding
B657_33670	COG1396	sequence-specific DNA binding
B657_33680	COG1733	regulation of RNA biosynthetic process
B657_33690	COG0840	transmembrane signaling receptor activity
B657_33700	COG1174	glycine betaine transport
B657_33710	COG1732	Glycine betaine
B657_33720	COG1174	glycine betaine transport
B657_33730	COG1125	glycine betaine transport
B657_33730	COG0517	IMP dehydrogenase activity
B657_33740	COG1510	regulation of RNA biosynthetic process
B657_33780	COG5658	integral membrane protein
B657_33790	COG0640	Transcriptional regulator
B657_33800	COG1174	glycine betaine transport
B657_33810	COG1732	Glycine betaine
B657_33820	COG1174	glycine betaine transport
B657_33830	COG0517	IMP dehydrogenase activity
B657_33830	COG1125	glycine betaine transport
B657_33840	COG1510	regulation of RNA biosynthetic process
B657_33850	COG2095	MarC family integral membrane protein
B657_33870	COG3064	Membrane
B657_33880	COG4640	response to antibiotic
B657_33890	COG0456	acetyltransferase
B657_33900	COG0148	phosphopyruvate hydratase activity
B657_33910	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
B657_33920	COG0149	triose-phosphate isomerase activity
B657_33930	COG0126	phosphoglycerate kinase activity
B657_33940	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
B657_33950	COG2390	Transcriptional regulator
B657_33960	COG2814	Major facilitator Superfamily
B657_33970	COG1609	Transcriptional regulator
B657_33980	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B657_33990	COG0583	DNA-binding transcription factor activity
B657_34000	COG0697	spore germination
B657_34010	COG1113	amino acid transport
B657_34020	COG3858	chitin binding
B657_34030	COG1556	Lactate utilization protein
B657_34040	COG1139	Iron-sulfur cluster binding protein
B657_34050	COG0247	lactate metabolic process
B657_34060	COG2197	response regulator
B657_34070	COG4585	Histidine kinase
B657_34080	COG0842	Transport permease protein
B657_34090	COG1131	(ABC) transporter
B657_34100	COG0596	Alpha beta hydrolase
B657_34110	COG2208	phosphoserine phosphatase activity
B657_34120	COG3867	Arabinogalactan endo-beta-1,4-galactanase
B657_34130	COG1874	Beta-galactosidase
B657_34140	COG3833	ABC-type maltose transport systems, permease component
B657_34150	COG1175	transmembrane transport
B657_34160	COG2182	Extracellular solute-binding protein
B657_34170	COG1609	Transcriptional regulator
B657_34180	COG2186	Transcriptional regulator
B657_34190	COG1620	l-lactate permease
B657_34200	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
B657_34220	COG5039	Polysaccharide pyruvyl transferase
B657_34230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B657_34240	COG0110	maltose O-acetyltransferase activity
B657_34250	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
B657_34265	COG2244	polysaccharide biosynthetic process
B657_34280	COG1216	Glycosyl transferase, family 2
B657_34290	COG5039	Polysaccharide pyruvyl transferase
B657_34300	COG1216	Glycosyl transferase, family 2
B657_34320	COG0438	transferase activity, transferring glycosyl groups
B657_34330	COG1215	transferase activity, transferring glycosyl groups
B657_34340	COG0438	transferase activity, transferring glycosyl groups
B657_34350	COG1086	Polysaccharide biosynthesis protein
B657_34360	COG0489	protein tyrosine kinase activity
B657_34370	COG3944	biosynthesis protein
B657_34380	COG1396	sequence-specific DNA binding
B657_34390	COG2272	Belongs to the type-B carboxylesterase lipase family
B657_34400	COG3479	Phenolic acid decarboxylase
B657_34430	COG1794	racemase activity, acting on amino acids and derivatives
B657_34440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
B657_34450	COG1621	beta-fructofuranosidase activity
B657_34460	COG1621	beta-fructofuranosidase activity
B657_34470	COG0531	amino acid
B657_34480	COG1309	transcriptional regulator
B657_34490	COG2076	Multidrug Resistance protein
B657_34500	COG2076	Multidrug Resistance protein
B657_34520	COG0277	FAD linked oxidase domain protein
B657_34530	COG3621	Patatin-like phospholipase
B657_34540	COG0740	serine-type endopeptidase activity
B657_34550	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
B657_34560	COG0366	Alpha amylase catalytic
B657_34570	COG1554	hydrolase, family 65, central catalytic
B657_34580	COG5521	maltodextrose utilization protein MalA
B657_34590	COG3833	ABC-type maltose transport systems, permease component
B657_34600	COG1175	transmembrane transport
B657_34610	COG2182	Extracellular solute-binding protein
B657_34620	COG0366	Alpha amylase catalytic
B657_34630	COG1609	Transcriptional regulator
B657_34640	COG1611	Belongs to the LOG family
B657_34650	COG1694	Mazg nucleotide pyrophosphohydrolase
B657_34660	COG0659	secondary active sulfate transmembrane transporter activity
B657_34670	COG0288	reversible hydration of carbon dioxide
B657_34680	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
B657_34690	COG0577	efflux transmembrane transporter activity
B657_34700	COG1136	(ABC) transporter
B657_34710	COG5002	protein histidine kinase activity
B657_34720	COG0745	RESPONSE REGULATOR receiver
B657_34730	COG2162	N-hydroxyarylamine O-acetyltransferase activity
B657_34740	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
B657_34750	COG1481	regulation of sporulation
B657_34760	COG0391	Required for morphogenesis under gluconeogenic growth conditions
B657_34770	COG1660	Displays ATPase and GTPase activities
B657_34780	COG1051	belongs to the nudix hydrolase family
B657_34790	COG0492	ferredoxin-NADP+ reductase activity
B657_34800	COG0791	NLP P60 protein
B657_34800	COG3883	PFAM NLP P60 protein
B657_34810	COG0457	Tetratricopeptide repeat
B657_34820	COG1132	(ABC) transporter
B657_34860	COG0140	phosphoribosyl-ATP diphosphatase activity
B657_34860	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
B657_34870	COG0107	imidazoleglycerol-phosphate synthase activity
B657_34880	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
B657_34890	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
B657_34900	COG0131	Imidazoleglycerol-phosphate dehydratase
B657_34910	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
B657_34920	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
B657_34930	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
B657_34940	COG4990	cell redox homeostasis
B657_34950	COG5297	Belongs to the glycosyl hydrolase family 6
B657_34960	COG0110	maltose O-acetyltransferase activity
B657_34970	COG0546	phosphoglycolate phosphatase activity
B657_34980	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
B657_34990	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
B657_35000	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
B657_35010	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
B657_35020	COG0363	glucosamine-6-phosphate deaminase activity
B657_35040	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B657_35050	COG1846	Transcriptional regulator
B657_35060	COG2124	cytochrome p450
B657_35080	COG1846	Transcriptional regulator
B657_35090	COG2814	Major facilitator Superfamily
B657_35100	COG1950	PFAM Membrane protein of
B657_35110	COG1983	PspC domain protein
B657_35120	COG3595	metallopeptidase activity
B657_35150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B657_35160	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
B657_35170	COG0556	nucleotide-excision repair
B657_35180	COG4897	Protein conserved in bacteria
B657_35190	COG3848	Pyruvate phosphate dikinase
B657_35190	COG0574	Belongs to the PEP-utilizing enzyme family
B657_35200	COG1309	transcriptional regulator
B657_35210	COG2814	Major facilitator Superfamily
B657_35220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B657_35240	COG0793	Belongs to the peptidase S41A family
B657_35240	COG3409	Peptidoglycan-binding domain 1 protein
B657_35250	COG2177	Part of the ABC transporter FtsEX involved in
B657_35260	COG2884	Cell division ATP-binding protein ftsE
B657_35270	COG2010	Cytochrome c
B657_35280	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B657_35300	COG0653	protein targeting
B657_35310	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
B657_35330	COG1516	flagellar protein fliS
B657_35340	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
B657_35350	COG1334	flagellar protein FlaG
B657_35360	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B657_35370	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
B657_35380	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
B657_35400	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
B657_35410	COG4786	Flagellar basal body rod
B657_35410	COG1256	bacterial-type flagellum assembly
B657_35420	COG3418	PFAM FlgN family protein
B657_35430	COG2747	anti-sigma28 factor FlgM
B657_35450	COG1040	competence protein
B657_35470	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
B657_35480	COG1307	EDD domain protein, DegV family
B657_35490	COG2197	response regulator
B657_35500	COG4585	Histidine kinase
B657_35510	COG1739	Uncharacterized protein family UPF0029
B657_35520	COG1316	TRANSCRIPTIONal
B657_35530	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
B657_35540	COG0438	transferase activity, transferring glycosyl groups
B657_35550	COG1215	transferase activity, transferring glycosyl groups
B657_35560	COG3206	protein involved in exopolysaccharide biosynthesis
B657_35570	COG3307	-O-antigen
B657_35580	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B657_35590	COG0438	transferase activity, transferring glycosyl groups
B657_35590	COG0297	glycogen (starch) synthase activity
B657_35600	COG2244	polysaccharide biosynthetic process
B657_35620	COG0860	N-Acetylmuramoyl-L-alanine amidase
B657_35620	COG2247	cell wall binding repeat
B657_35630	COG2385	sporulation resulting in formation of a cellular spore
B657_35630	COG2247	cell wall binding repeat
B657_35650	COG1316	TRANSCRIPTIONal
B657_35660	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
B657_35670	COG1210	Utp--glucose-1-phosphate uridylyltransferase
B657_35680	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B657_35680	COG1215	transferase activity, transferring glycosyl groups
B657_35690	COG0463	Glycosyl transferase, family 2
B657_35700	COG1134	teichoic acid transport
B657_35710	COG1682	transport, permease protein
B657_35720	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B657_35730	COG0438	transferase activity, transferring glycosyl groups
B657_35740	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
B657_35750	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
B657_35760	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B657_35780	COG4193	domain, Protein
B657_35790	COG1482	cell wall glycoprotein biosynthetic process
B657_35800	COG0697	spore germination
B657_35810	COG0814	amino acid
B657_35830	COG2814	Major facilitator Superfamily
B657_35840	COG1316	TRANSCRIPTIONal
B657_35850	COG0561	phosphatase activity
B657_35860	COG0791	NLP P60 protein
B657_35880	COG2843	Capsule synthesis protein
B657_35900	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
B657_35910	COG1609	Transcriptional regulator
B657_35920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B657_35930	COG1869	D-ribose catabolic process
B657_35940	COG1129	ABC transporter
B657_35950	COG1172	Belongs to the binding-protein-dependent transport system permease family
B657_35960	COG1879	ABC-type sugar transport system periplasmic component
B657_35970	COG3103	Sh3 type 3 domain protein
B657_35990	COG2249	NAD(P)H dehydrogenase (quinone) activity
B657_36000	COG3527	Alpha-acetolactate decarboxylase
B657_36010	COG0028	Belongs to the TPP enzyme family
B657_36020	COG0583	DNA-binding transcription factor activity
B657_36030	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
B657_36060	COG5337	Spore coat protein CotH
B657_36080	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
B657_36100	COG0405	Gamma-glutamyltransferase
B657_36110	COG1522	sequence-specific DNA binding
B657_36120	COG2059	Chromate
B657_36130	COG2059	Chromate
B657_36150	COG0655	NAD(P)H dehydrogenase (quinone) activity
B657_36160	COG0583	DNA-binding transcription factor activity
B657_36170	COG1515	deoxyribonuclease V activity
B657_36180	COG2849	repeat protein
B657_36190	COG5444	nuclease activity
B657_36220	COG3878	Protein conserved in bacteria
B657_36230	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
B657_36240	COG4464	protein tyrosine phosphatase activity
B657_36250	COG0489	protein tyrosine kinase activity
B657_36260	COG3944	biosynthesis protein
B657_36270	COG4715	Zinc finger, swim domain protein
B657_36280	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
B657_36290	COG0561	phosphatase activity
B657_36300	COG1349	DNA-binding transcription factor activity
B657_36310	COG0629	single-stranded DNA binding
B657_36340	COG3764	Sortase (surface protein transpeptidase)
B657_36350	COG2972	Histidine kinase
B657_36350	COG0745	RESPONSE REGULATOR receiver
B657_36360	COG1970	mechanosensitive ion channel activity
B657_36370	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
B657_36380	COG0457	Tetratricopeptide repeat
B657_36390	COG4786	Flagellar basal body rod
B657_36400	COG4786	Flagellar basal body rod
B657_36410	COG1077	Cell shape determining protein MreB Mrl
B657_36420	COG1609	Transcriptional regulator
B657_36440	COG1846	Transcriptional regulator
B657_36450	COG2814	Major facilitator Superfamily
B657_36460	COG3420	alginic acid biosynthetic process
B657_36470	COG1953	Uracil, thiamine, allantoin
B657_36480	COG0477	Major facilitator Superfamily
B657_36490	COG1335	isochorismatase
B657_36510	COG0004	ammonium transporteR
B657_36520	COG0347	Belongs to the P(II) protein family
B657_36530	COG0671	phosphoesterase, PA-phosphatase related
B657_36550	COG0739	heme binding
B657_36560	COG1247	-acetyltransferase
B657_36590	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B657_36600	COG0789	Transcriptional regulator
B657_36620	COG2910	NAD(P)H-binding
B657_36630	COG1959	2 iron, 2 sulfur cluster binding
B657_36640	COG0804	urea catabolic process
B657_36650	COG0832	Belongs to the urease beta subunit family
B657_36660	COG0831	urea catabolic process
B657_36670	COG3237	CsbD-like
B657_36680	COG1994	Peptidase M50
B657_36690	COG0457	Tetratricopeptide repeat
B657_36700	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
B657_36710	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
B657_36730	COG2304	oxidoreductase activity
B657_36740	COG2304	oxidoreductase activity
B657_36750	COG2385	sporulation resulting in formation of a cellular spore
B657_36760	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B657_36780	COG4836	Membrane
B657_36800	COG0355	proton-transporting ATP synthase activity, rotational mechanism
B657_36810	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
B657_36820	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
B657_36830	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
B657_36840	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B657_36850	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
B657_36860	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
B657_36890	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
B657_36900	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
B657_36910	COG4475	Protein of unknown function (DUF436)
B657_36920	COG0698	ribose 5-phosphate isomerase
B657_36930	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
B657_36940	COG1971	Probably functions as a manganese efflux pump
B657_36950	COG0009	L-threonylcarbamoyladenylate synthase
B657_36960	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
B657_37000	COG2890	protein-(glutamine-N5) methyltransferase activity
B657_37010	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
B657_37020	COG0346	lactoylglutathione lyase activity
B657_37030	COG0789	Transcriptional regulator
B657_37040	COG0679	Auxin Efflux Carrier
B657_37050	COG0281	malic enzyme
B657_37060	COG1435	thymidine kinase activity
B657_37070	COG0254	rRNA binding
B657_37080	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
B657_37090	COG1494	fructose-1,6-bisphosphatase
B657_37100	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
B657_37110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
B657_37120	COG0191	fructose-bisphosphate aldolase activity
B657_37130	COG2204	response regulator
B657_37140	COG4821	SIS domain
B657_37150	COG0504	CTP synthase activity
B657_37160	COG3343	RNA polymerase activity
B657_37170	COG1960	acyl-CoA dehydrogenase activity
B657_37180	COG0247	lactate metabolic process
B657_37180	COG2181	nitrate reductase activity
B657_37190	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B657_37200	COG4294	response to UV
B657_37220	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B657_37230	COG1132	(ABC) transporter
B657_37240	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
B657_37250	COG2181	nitrate reductase activity
B657_37260	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
B657_37270	COG1140	nitrate reductase beta subunit
B657_37280	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
B657_37290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B657_37310	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
B657_37320	COG2223	nitrite transmembrane transporter activity
B657_37330	COG0018	arginyl-trna synthetase
B657_37340	COG4506	Protein conserved in bacteria
B657_37370	COG0535	radical SAM domain protein
B657_37390	COG1131	(ABC) transporter
B657_37400	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
B657_37410	COG0612	Peptidase, M16
B657_37420	COG0612	Peptidase, M16
B657_37440	COG3391	amine dehydrogenase activity
B657_37450	COG3391	amine dehydrogenase activity
B657_37460	COG0457	Tetratricopeptide repeat
B657_37480	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
B657_37490	COG0010	Belongs to the arginase family
B657_37500	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
B657_37510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
B657_37530	COG1994	Peptidase M50
B657_37540	COG1942	4-Oxalocrotonate Tautomerase
B657_37550	COG1846	Transcriptional regulator
B657_37560	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
B657_37570	COG0477	Major facilitator Superfamily
B657_37580	COG1959	2 iron, 2 sulfur cluster binding
B657_37590	COG3465	dGTPase activity
B657_37600	COG1078	dGTPase activity
B657_37610	COG4844	belongs to the
B657_37630	COG0697	spore germination
B657_37640	COG0095	Lipoate-protein ligase
B657_37650	COG0583	DNA-binding transcription factor activity
B657_37660	COG0280	phosphate acetyltransferase
B657_37680	COG1028	Short-chain dehydrogenase reductase Sdr
B657_37690	COG0436	Aminotransferase
B657_37700	COG2814	Major facilitator Superfamily
B657_37710	COG0151	Belongs to the GarS family
B657_37720	COG1028	Short-chain dehydrogenase reductase Sdr
B657_37730	COG1917	Cupin 2, conserved barrel domain protein
B657_37740	COG0077	Prephenate dehydratase
B657_37750	COG2814	Major facilitator Superfamily
B657_37760	COG0833	amino acid
B657_37770	COG4187	Peptidase family M20/M25/M40
B657_37780	COG1012	belongs to the aldehyde dehydrogenase family
B657_37790	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
B657_37810	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
B657_37820	COG1091	dTDP-4-dehydrorhamnose reductase activity
B657_37830	COG1088	dTDP-glucose 4,6-dehydratase activity
B657_37840	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
B657_37850	COG3980	spore coat polysaccharide biosynthesis protein
B657_37860	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
B657_37870	COG2089	acid synthase
B657_37880	COG0456	acetyltransferase
B657_37890	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
B657_37900	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
B657_37910	COG0463	Glycosyl transferase, family 2
B657_37930	COG2363	Small membrane protein
B657_37940	COG2233	PERMEase
B657_37960	COG1012	belongs to the aldehyde dehydrogenase family
B657_37970	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
B657_37980	COG1216	Glycosyl transferase, family 2
B657_38018	COG1695	Transcriptional regulator
B657_38020	COG0351	phosphomethylpyrimidine kinase
B657_38040	COG1621	beta-fructofuranosidase activity
B657_38050	COG1263	PTS System
B657_38050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B657_38060	COG2116	formate transmembrane transporter activity
B657_38070	COG3711	transcriptional antiterminator
B657_38090	COG1404	Belongs to the peptidase S8 family
B657_38100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
B657_38110	COG0778	Nitroreductase
B657_38120	COG0772	Belongs to the SEDS family
B657_38140	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
B657_38150	COG1845	cytochrome c oxidase, subunit III
B657_38160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
B657_38170	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
B657_38180	COG2261	transglycosylase associated protein
B657_38190	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
B657_38200	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
B657_38210	COG2246	polysaccharide biosynthetic process
B657_38220	COG1309	transcriptional regulator
B657_38230	COG3162	membrane
B657_38240	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
B657_38250	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
B657_38260	COG2837	iron assimilation
B657_38270	COG2822	iron ion transport
B657_38280	COG0672	)-iron permease
B657_38290	COG0352	thiamine-phosphate diphosphorylase activity
B657_38300	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
B657_38310	COG0583	DNA-binding transcription factor activity
B657_38320	COG1380	Effector of murein hydrolase LrgA
B657_38330	COG1346	cytolysis
B657_38340	COG2814	Major facilitator Superfamily
B657_38350	COG4895	conserved protein (DUF2196)
B657_38360	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
B657_38370	COG0346	lactoylglutathione lyase activity
B657_38390	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B657_38400	COG1404	Belongs to the peptidase S8 family
B657_38410	COG1263	PTS System
B657_38410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B657_38420	COG3711	transcriptional antiterminator
B657_38430	COG1442	glycosyl transferase family 8
B657_38440	COG5522	Integral membrane protein (intg_mem_TP0381)
B657_38450	COG1846	Transcriptional regulator
B657_38460	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
B657_38470	COG2234	aminopeptidase activity
B657_38480	COG2357	RelA SpoT domain protein
B657_38490	COG1575	Belongs to the MenA family. Type 1 subfamily
B657_38500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
B657_38510	COG1696	Membrane protein involved in D-alanine export
B657_38520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
B657_38530	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
B657_38540	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
B657_38550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
B657_38560	COG1486	melibiose metabolic process
B657_38570	COG1447	Phosphotransferase system cellobiose-specific component IIA
B657_38580	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B657_38590	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
B657_38600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
B657_38600	COG3711	transcriptional antiterminator
B657_38620	COG2094	Belongs to the DNA glycosylase MPG family
B657_38630	COG0753	catalase activity
B657_38640	COG2814	Major facilitator Superfamily
B657_38650	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
B657_38660	COG1131	(ABC) transporter
B657_38700	COG1595	DNA-templated transcription, initiation
B657_38710	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
B657_38720	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
B657_38730	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
B657_38740	COG4988	ABC transporter
B657_38750	COG1294	oxidase, subunit
B657_38760	COG1271	oxidase subunit
B657_38770	COG3493	citrate carrier protein
B657_38780	COG0501	Belongs to the peptidase M48B family
B657_38800	COG0726	polysaccharide deacetylase
B657_38810	COG3842	ATPase activity
B657_38820	COG2508	Transcriptional regulator
B657_38830	COG1012	belongs to the aldehyde dehydrogenase family
B657_38840	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
B657_38860	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
B657_38870	COG1881	PFAM PEBP family protein
B657_38880	COG0583	DNA-binding transcription factor activity
B657_38900	COG4585	Histidine kinase
B657_38910	COG2197	response regulator
B657_38920	COG2195	Cleaves the N-terminal amino acid of tripeptides
B657_38940	COG4894	glucomannan catabolic process
B657_38950	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B657_38960	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
B657_38970	COG1028	Short-chain dehydrogenase reductase Sdr
B657_38980	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
B657_38990	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
B657_39000	COG2610	gluconate transmembrane transporter activity
B657_39010	COG0500	methyltransferase
B657_39020	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B657_39050	COG0753	catalase activity
B657_39050	COG0693	protein deglycase activity
B657_39060	COG2851	Citrate transporter
B657_39070	COG2273	Hydrolase Family 16
B657_39080	COG3711	transcriptional antiterminator
B657_39100	COG2270	Major facilitator Superfamily
B657_39110	COG0513	Belongs to the DEAD box helicase family
B657_39120	COG2755	lipolytic protein G-D-S-L family
B657_39120	COG3401	FG-GAP repeat protein
B657_39230	COG3209	COG3209 Rhs family protein
B657_39240	COG0697	spore germination
B657_39250	COG0589	response to stress
B657_39260	COG2723	6-phospho-beta-galactosidase activity
B657_39270	COG1263	PTS System
B657_39270	COG2190	(PTS) system
B657_39270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
B657_39300	COG5444	nuclease activity
B657_39330	COG3507	Belongs to the glycosyl hydrolase 43 family
B657_39350	COG2986	histidine ammonia-lyase
B657_39360	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
B657_39370	COG1228	amidohydrolase
B657_39380	COG0010	Belongs to the arginase family
B657_39390	COG0833	amino acid
B657_39400	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
B657_39410	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
B657_39420	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
B657_39430	COG2390	Transcriptional regulator
B657_39450	COG3192	ethanolamine utilization protein
B657_39460	COG2079	MmgE PrpD family protein
B657_39480	COG1126	abc transporter atp-binding protein
B657_39490	COG0765	amino acid transport
B657_39500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
B657_39540	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
B657_39550	COG0561	phosphatase activity
B657_39610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
B657_39620	COG5294	Protein conserved in bacteria
B657_39630	COG0577	efflux transmembrane transporter activity
B657_39640	COG1136	(ABC) transporter
B657_39650	COG2205	protein histidine kinase activity
B657_39660	COG0745	RESPONSE REGULATOR receiver
B657_39670	COG0191	fructose-bisphosphate aldolase activity
B657_39680	COG1082	Xylose isomerase domain protein TIM barrel
B657_39690	COG1082	Xylose isomerase domain protein TIM barrel
B657_39700	COG0673	inositol 2-dehydrogenase activity
B657_39710	COG2814	Major facilitator Superfamily
B657_39720	COG1082	Xylose isomerase domain protein TIM barrel
B657_39730	COG3962	Belongs to the TPP enzyme family
B657_39740	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
B657_39750	COG3718	enzyme involved in inositol metabolism
B657_39760	COG1012	belongs to the aldehyde dehydrogenase family
B657_39770	COG1349	DNA-binding transcription factor activity
B657_39780	COG0667	Aldo Keto reductase
B657_39810	COG2814	Major facilitator Superfamily
B657_39820	COG0326	Molecular chaperone. Has ATPase activity
B657_39840	COG1028	Short-chain dehydrogenase reductase Sdr
B657_39850	COG1309	transcriptional regulator
B657_39860	COG1012	belongs to the aldehyde dehydrogenase family
B657_39870	COG0456	acetyltransferase
B657_39880	COG2850	peptidyl-arginine hydroxylation
B657_39890	COG2226	methyltransferase
B657_39920	COG0367	asparagine synthase
B657_39930	COG2814	Major facilitator Superfamily
B657_39940	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
B657_39960	COG1714	RDD family
B657_39970	COG2311	Membrane
B657_39980	COG1917	Cupin 2, conserved barrel domain protein
B657_39990	COG1309	transcriptional regulator
B657_40000	COG1028	Short-chain dehydrogenase reductase Sdr
B657_40010	COG1846	Transcriptional regulator
B657_40021	COG1380	Effector of murein hydrolase LrgA
B657_40022	COG1346	cytolysis
B657_40030	COG5039	Polysaccharide pyruvyl transferase
B657_40040	COG1929	Belongs to the glycerate kinase type-1 family
B657_40050	COG1802	Transcriptional regulator
B657_40060	COG1070	Carbohydrate kinase
B657_40070	COG2610	gluconate transmembrane transporter activity
B657_40080	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
B657_40090	COG0450	alkyl hydroperoxide reductase
B657_40100	COG3634	alkyl hydroperoxide reductase activity
B657_40110	COG2723	6-phospho-beta-galactosidase activity
B657_40120	COG2190	(PTS) system
B657_40130	COG2188	Transcriptional regulator
B657_40150	COG1131	(ABC) transporter
B657_40160	COG1994	Peptidase M50
B657_40170	COG0535	radical SAM domain protein
B657_40190	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
B657_40200	COG5293	efflux transmembrane transporter activity
B657_40220	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
B657_40230	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
B657_40250	COG1063	alcohol dehydrogenase
B657_40280	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
B657_40290	COG0456	acetyltransferase
B657_40300	COG0457	Tetratricopeptide repeat
B657_40320	COG0010	Belongs to the arginase family
B657_40330	COG0833	amino acid
B657_40340	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
B657_40350	COG3829	transcription factor binding
B657_40360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
B657_40370	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
B657_40380	COG4853	Protein conserved in bacteria
B657_40390	COG4863	YycH protein
B657_40400	COG5002	protein histidine kinase activity
B657_40410	COG0745	RESPONSE REGULATOR receiver
B657_40430	COG0346	lactoylglutathione lyase activity
B657_40440	COG0305	Participates in initiation and elongation during chromosome replication
B657_40470	COG3093	addiction module antidote protein HigA
B657_40480	COG2807	transmembrane transport
B657_40490	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
B657_40500	COG0359	binds to the 23S rRNA
B657_40510	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
B657_40520	COG4241	membrane
B657_40530	COG5577	PFAM Coat F domain
B657_40540	COG1733	regulation of RNA biosynthetic process
B657_40550	COG1227	inorganic diphosphatase activity
B657_40570	COG2271	Major facilitator Superfamily
B657_40620	COG1131	(ABC) transporter
B657_40640	COG4319	ketosteroid isomerase
B657_40650	COG1357	PFAM Pentapeptide repeats (8 copies)
B657_40660	COG2814	Major facilitator Superfamily
B657_40670	COG0583	DNA-binding transcription factor activity
B657_40680	COG2153	protein acetylation
B657_40700	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
B657_40710	COG1846	Transcriptional regulator
B657_40720	COG2153	protein acetylation
B657_40730	COG2364	Membrane
B657_40740	COG0456	acetyltransferase
B657_40750	COG2315	Protein conserved in bacteria
B657_40760	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
B657_40770	COG2814	Major facilitator Superfamily
B657_40790	COG1331	Highly conserved protein containing a thioredoxin domain
B657_40800	COG0789	Transcriptional regulator
B657_40810	COG0697	spore germination
B657_40820	COG1331	Highly conserved protein containing a thioredoxin domain
B657_40830	COG1266	CAAX protease self-immunity
B657_40840	COG2814	Major facilitator Superfamily
B657_40840	COG0477	Major facilitator Superfamily
B657_40850	COG0110	maltose O-acetyltransferase activity
B657_40860	COG0346	lactoylglutathione lyase activity
B657_40870	COG1609	Transcriptional regulator
B657_40880	COG0708	Exodeoxyribonuclease III
B657_40890	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
B657_40900	COG0629	single-stranded DNA binding
B657_40910	COG0360	Binds together with S18 to 16S ribosomal RNA
B657_40920	COG0012	GTP binding
B657_40930	COG0243	molybdopterin cofactor binding
B657_40939	COG4481	Protein conserved in bacteria
B657_40940	COG3949	Membrane
B657_40960	COG1475	DNA binding
B657_40970	COG1192	Involved in chromosome partitioning
B657_40990	COG1475	DNA binding
B657_41000	COG0357	Ribosomal RNA small subunit methyltransferase G
B657_41010	COG0445	tRNA wobble uridine modification
B657_41020	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
B657_41030	COG1847	R3H domain protein
B657_41040	COG0706	membrane insertase activity
B657_41050	COG0594	ribonuclease P activity
B657_41060	COG0230	Belongs to the bacterial ribosomal protein bL34 family