locus-tag	class	description
GO004_00005	COG4978	Transcriptional regulator
GO004_00005	COG0789	Transcriptional regulator
GO004_00015	COG3959	Transketolase, thiamine diphosphate binding domain
GO004_00020	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GO004_00025	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_00040	COG2186	Transcriptional regulator
GO004_00050	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GO004_00055	COG2070	2-Nitropropane dioxygenase
GO004_00065	COG2318	DinB family
GO004_00075	COG1335	isochorismatase
GO004_00085	COG2124	cytochrome p450
GO004_00095	COG1522	sequence-specific DNA binding
GO004_00100	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
GO004_00105	COG1687	branched-chain amino acid
GO004_00110	COG1114	Component of the transport system for branched-chain amino acids
GO004_00120	COG0583	DNA-binding transcription factor activity
GO004_00125	COG1942	4-Oxalocrotonate Tautomerase
GO004_00130	COG1230	cation diffusion facilitator family transporter
GO004_00135	COG2072	flavoprotein involved in K transport
GO004_00140	COG0583	DNA-binding transcription factor activity
GO004_00145	COG0697	spore germination
GO004_00155	COG1253	flavin adenine dinucleotide binding
GO004_00160	COG0456	acetyltransferase
GO004_00165	COG2814	Major facilitator Superfamily
GO004_00170	COG4978	Transcriptional regulator
GO004_00170	COG0789	Transcriptional regulator
GO004_00180	COG0662	Cupin 2, conserved barrel domain protein
GO004_00185	COG1937	Protein conserved in bacteria
GO004_00190	COG2210	Belongs to the sulfur carrier protein TusA family
GO004_00195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO004_00195	COG0425	Belongs to the sulfur carrier protein TusA family
GO004_00205	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO004_00205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO004_00210	COG0425	Belongs to the sulfur carrier protein TusA family
GO004_00215	COG0730	response to heat
GO004_00220	COG4124	Belongs to the glycosyl hydrolase 26 family
GO004_00240	COG2856	Zn peptidase
GO004_00245	COG0563	adenylate kinase activity
GO004_00255	COG3620	sequence-specific DNA binding
GO004_00260	COG1476	TRANSCRIPTIONal
GO004_00290	COG5377	YqaJ viral recombinase family
GO004_00295	COG3723	Recombinational DNA repair protein, rece pathway
GO004_00300	COG3935	DnaD domain protein
GO004_00305	COG1484	DNA-dependent DNA replication
GO004_00315	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
GO004_00330	COG3677	Transposase
GO004_00340	COG5484	DNA packaging
GO004_00345	COG1783	phage Terminase large subunit
GO004_00350	COG5518	Phage portal protein
GO004_00355	COG2369	cell adhesion
GO004_00365	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GO004_00370	COG4653	Phage capsid family
GO004_00430	COG3953	SLT domain
GO004_00430	COG5280	Phage tail tape measure protein TP901
GO004_00435	COG1652	LysM domain
GO004_00440	COG4193	domain, Protein
GO004_00450	COG1794	racemase activity, acting on amino acids and derivatives
GO004_00455	COG3628	GPW Gp25 family protein
GO004_00460	COG3299	homolog of phage Mu protein gp47
GO004_00465	COG3778	Protein conserved in bacteria
GO004_00495	COG4824	toxin secretion phage lysis holin
GO004_00500	COG5632	N-Acetylmuramoyl-L-alanine amidase
GO004_00500	COG3409	Peptidoglycan-binding domain 1 protein
GO004_00525	COG5444	nuclease activity
GO004_00540	COG0457	Tetratricopeptide repeat
GO004_00565	COG0604	alcohol dehydrogenase
GO004_00585	COG3403	YqcI/YcgG family
GO004_00590	COG0640	Transcriptional regulator
GO004_00595	COG0346	lactoylglutathione lyase activity
GO004_00600	COG0798	PFAM Bile acid sodium symporter
GO004_00605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GO004_00610	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GO004_00620	COG3209	COG3209 Rhs family protein
GO004_00630	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
GO004_00635	COG0398	Pfam SNARE associated Golgi protein
GO004_00640	COG3409	Peptidoglycan-binding domain 1 protein
GO004_00640	COG5632	N-Acetylmuramoyl-L-alanine amidase
GO004_00645	COG2755	lipolytic protein G-D-S-L family
GO004_00655	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
GO004_00660	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GO004_00665	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
GO004_00670	COG1534	Rna-binding protein
GO004_00675	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
GO004_00680	COG1713	HD superfamily hydrolase involved in NAD metabolism
GO004_00685	COG0799	negative regulation of ribosome biogenesis
GO004_00690	COG2226	methyltransferase
GO004_00695	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GO004_00700	COG1596	polysaccharide export
GO004_00700	COG1555	photosystem II stabilization
GO004_00705	COG2131	deaminase
GO004_00710	COG2333	competence protein COMEC
GO004_00710	COG0658	competence protein
GO004_00725	COG1466	dna polymerase III delta subunit
GO004_00730	COG0268	Binds directly to 16S ribosomal RNA
GO004_00735	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
GO004_00740	COG0860	N-Acetylmuramoyl-L-alanine amidase
GO004_00750	COG0481	GTPase activity
GO004_00755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GO004_00760	COG1420	regulation of RNA biosynthetic process
GO004_00765	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
GO004_00770	COG0443	Heat shock 70 kDa protein
GO004_00775	COG0484	heat shock protein binding
GO004_00780	COG2264	protein methyltransferase activity
GO004_00785	COG1385	rRNA (uridine-N3-)-methyltransferase activity
GO004_00790	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GO004_00795	COG1283	sodium-dependent phosphate transmembrane transporter activity
GO004_00805	COG1610	YqeY-like protein
GO004_00810	COG1030	water channel activity
GO004_00815	COG4864	UPF0365 protein
GO004_00830	COG0561	phosphatase activity
GO004_00835	COG1702	phosphate starvation-inducible protein PhoH
GO004_00840	COG1480	7TM receptor with intracellular HD hydrolase
GO004_00845	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
GO004_00850	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
GO004_00855	COG0295	cytidine deaminase activity
GO004_00860	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
GO004_00870	COG1381	Involved in DNA repair and RecF pathway recombination
GO004_00875	COG0752	glycyl-tRNA synthetase alpha subunit
GO004_00880	COG0751	glycine-tRNA ligase activity
GO004_00885	COG0517	IMP dehydrogenase activity
GO004_00890	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
GO004_00895	COG1671	Belongs to the UPF0178 family
GO004_00900	COG0358	DNA primase activity
GO004_00905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
GO004_00910	COG2010	Cytochrome c
GO004_00915	COG2384	SAM-dependent methyltransferase
GO004_00920	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
GO004_00925	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
GO004_00935	COG0513	Belongs to the DEAD box helicase family
GO004_00940	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
GO004_00950	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GO004_00955	COG0735	belongs to the Fur family
GO004_00960	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
GO004_00965	COG4709	membrane
GO004_00970	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
GO004_00975	COG1388	LysM domain
GO004_00980	COG5521	maltodextrose utilization protein MalA
GO004_00985	COG2839	Protein conserved in bacteria
GO004_00990	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GO004_00995	COG0477	Major facilitator Superfamily
GO004_01000	COG0768	penicillin binding
GO004_01005	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
GO004_01010	COG0573	inorganic phosphate transmembrane transporter activity
GO004_01015	COG0581	inorganic phosphate transmembrane transporter activity
GO004_01020	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GO004_01025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GO004_01030	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GO004_01045	COG0438	transferase activity, transferring glycosyl groups
GO004_01055	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
GO004_01065	COG0705	Rhomboid family
GO004_01065	COG0457	Tetratricopeptide repeat
GO004_01070	COG4483	Protein conserved in bacteria
GO004_01075	COG1940	carbohydrate kinase activity
GO004_01080	COG1368	sulfuric ester hydrolase activity
GO004_01085	COG2866	Carboxypeptidase
GO004_01095	COG0011	TIGRFAM Protein of
GO004_01105	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO004_01115	COG1393	Belongs to the ArsC family
GO004_01125	COG1366	Belongs to the anti-sigma-factor antagonist family
GO004_01130	COG1253	flavin adenine dinucleotide binding
GO004_01135	COG0598	Magnesium transport protein CorA
GO004_01140	COG0517	IMP dehydrogenase activity
GO004_01145	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
GO004_01150	COG1459	type II secretion system
GO004_01155	COG4537	Required for transformation and DNA binding
GO004_01160	COG4970	Tfp pilus assembly protein FimT
GO004_01170	COG4940	Competence protein ComGF
GO004_01195	COG0681	Belongs to the peptidase S26 family
GO004_01205	COG1396	sequence-specific DNA binding
GO004_01220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GO004_01225	COG0404	The glycine cleavage system catalyzes the degradation of glycine
GO004_01230	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GO004_01235	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
GO004_01240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO004_01245	COG0095	Lipoate-protein ligase
GO004_01250	COG1321	iron dependent repressor
GO004_01255	COG1752	Esterase of the alpha-beta hydrolase superfamily
GO004_01265	COG3872	metal-dependent enzyme
GO004_01275	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
GO004_01280	COG0006	proline dipeptidase activity
GO004_01285	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
GO004_01295	COG3854	ATPases associated with a variety of cellular activities
GO004_01335	COG0511	ligase activity, forming carbon-carbon bonds
GO004_01340	COG0439	Biotin carboxylase
GO004_01345	COG1302	Protein conserved in bacteria
GO004_01350	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GO004_01355	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
GO004_01360	COG1570	exodeoxyribonuclease VII activity
GO004_01365	COG1722	exodeoxyribonuclease VII activity
GO004_01370	COG0142	geranyltranstransferase activity
GO004_01375	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
GO004_01380	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
GO004_01385	COG1438	arginine binding
GO004_01390	COG0497	DNA recombination
GO004_01395	COG0750	zinc metalloprotease
GO004_01400	COG0745	RESPONSE REGULATOR receiver
GO004_01405	COG1902	pentaerythritol trinitrate reductase activity
GO004_01420	COG0860	N-Acetylmuramoyl-L-alanine amidase
GO004_01425	COG0584	glycerophosphoryl diester phosphodiesterase
GO004_01430	COG0183	Belongs to the thiolase family
GO004_01435	COG1250	3-hydroxyacyl-CoA dehydrogenase
GO004_01440	COG1960	acyl-CoA dehydrogenase activity
GO004_01445	COG0372	Belongs to the citrate synthase family
GO004_01450	COG2079	MmgE PrpD family protein
GO004_01455	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
GO004_01465	COG3829	transcription factor binding
GO004_01465	COG3290	protein histidine kinase activity
GO004_01470	COG0280	phosphate acetyltransferase
GO004_01475	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GO004_01480	COG3426	butyrate kinase activity
GO004_01485	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GO004_01490	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO004_01495	COG0022	dehydrogenase e1 component
GO004_01500	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO004_01505	COG4978	Transcriptional regulator
GO004_01505	COG0789	Transcriptional regulator
GO004_01510	COG2814	Major facilitator Superfamily
GO004_01515	COG1597	lipid kinase activity
GO004_01525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO004_01530	COG0765	amino acid transport
GO004_01535	COG1126	abc transporter atp-binding protein
GO004_01540	COG4129	membrane
GO004_01545	COG1376	ErfK ybiS ycfS ynhG family protein
GO004_01555	COG0346	lactoylglutathione lyase activity
GO004_01560	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GO004_01565	COG2195	Cleaves the N-terminal amino acid of tripeptides
GO004_01570	COG3361	conserved protein (COG2071)
GO004_01575	COG0706	membrane insertase activity
GO004_01585	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GO004_01590	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GO004_01595	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
GO004_01600	COG1234	tRNA 3'-trailer cleavage
GO004_01610	COG0596	Alpha beta hydrolase
GO004_01615	COG1902	pentaerythritol trinitrate reductase activity
GO004_01620	COG4187	Peptidase family M20/M25/M40
GO004_01625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GO004_01630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO004_01635	COG0300	oxidoreductase activity
GO004_01640	COG3048	D-serine ammonia-lyase activity
GO004_01645	COG1072	(Pantothenic acid kinase))
GO004_01650	COG0346	lactoylglutathione lyase activity
GO004_01655	COG2211	Major facilitator Superfamily
GO004_01665	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GO004_01675	COG0456	acetyltransferase
GO004_01680	COG2329	Antibiotic biosynthesis monooxygenase
GO004_01685	COG0456	acetyltransferase
GO004_01685	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
GO004_01690	COG4918	Iron-sulphur cluster biosynthesis
GO004_01700	COG1073	alpha beta
GO004_01710	COG0667	Aldo Keto reductase
GO004_01720	COG0494	nUDIX hydrolase
GO004_01725	COG1379	DNA repair
GO004_01730	COG1396	sequence-specific DNA binding
GO004_01735	COG0252	asparaginase activity
GO004_01740	COG1027	Aspartate ammonia-lyase
GO004_01745	COG1757	Na H antiporter
GO004_01750	COG0281	malic enzyme
GO004_01760	COG1300	Membrane
GO004_01765	COG0735	belongs to the Fur family
GO004_01775	COG4974	Belongs to the 'phage' integrase family
GO004_01780	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
GO004_01785	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
GO004_01790	COG1686	Belongs to the peptidase S11 family
GO004_01795	COG1366	Belongs to the anti-sigma-factor antagonist family
GO004_01800	COG2172	sigma factor antagonist activity
GO004_01805	COG1191	sigma factor activity
GO004_01825	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GO004_01840	COG0697	spore germination
GO004_01845	COG0019	diaminopimelate decarboxylase activity
GO004_01850	COG4086	secreted protein
GO004_01855	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
GO004_01890	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
GO004_01900	COG0681	Belongs to the peptidase S26 family
GO004_01910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GO004_01910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
GO004_01915	COG0307	riboflavin synthase, alpha
GO004_01920	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GO004_01920	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
GO004_01925	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
GO004_01930	COG0456	acetyltransferase
GO004_01935	COG1547	Domain of unknown function (DUF309)
GO004_01940	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
GO004_01945	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
GO004_01955	COG1686	Belongs to the peptidase S11 family
GO004_01960	COG2715	membrane protein required for spore maturation
GO004_01965	COG0700	Nucleoside recognition
GO004_01970	COG1187	pseudouridine synthase activity
GO004_01975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO004_01980	COG1333	cytochrome c biogenesis protein
GO004_01985	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GO004_01990	COG0745	RESPONSE REGULATOR receiver
GO004_01995	COG5002	protein histidine kinase activity
GO004_02000	COG1595	DNA-templated transcription, initiation
GO004_02010	COG0710	3-dehydroquinate dehydratase activity
GO004_02015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GO004_02020	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
GO004_02025	COG1141	Ferredoxin
GO004_02030	COG4955	Helix-turn-helix domain
GO004_02035	COG0514	ATP-dependent DNA helicase (RecQ)
GO004_02040	COG1266	CAAX protease self-immunity
GO004_02045	COG1388	LysM domain
GO004_02055	COG1408	metallophosphoesterase
GO004_02060	COG4862	establishment of competence for transformation
GO004_02065	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GO004_02070	COG0492	ferredoxin-NADP+ reductase activity
GO004_02075	COG2339	peptidase activity
GO004_02080	COG3773	Cell wall hydrolase
GO004_02080	COG3409	Peptidoglycan-binding domain 1 protein
GO004_02085	COG2959	enzyme of heme biosynthesis
GO004_02090	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
GO004_02100	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
GO004_02105	COG0539	negative regulation of cytoplasmic translation
GO004_02110	COG1304	FMN binding
GO004_02135	COG1160	GTP binding
GO004_02140	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
GO004_02155	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GO004_02160	COG0776	regulation of translation
GO004_02165	COG0302	gtp cyclohydrolase
GO004_02175	COG0142	geranyltranstransferase activity
GO004_02180	COG2226	methyltransferase
GO004_02185	COG0142	geranyltranstransferase activity
GO004_02190	COG0105	UTP biosynthetic process
GO004_02195	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
GO004_02200	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
GO004_02205	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
GO004_02210	COG4401	Chorismate mutase type I
GO004_02215	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GO004_02220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
GO004_02230	COG0135	phosphoribosylanthranilate isomerase activity
GO004_02235	COG0133	tryptophan synthase activity
GO004_02240	COG0159	tryptophan synthase activity
GO004_02245	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
GO004_02250	COG0287	Prephenate dehydrogenase
GO004_02255	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
GO004_02260	COG0457	Tetratricopeptide repeat
GO004_02265	COG5582	Belongs to the UPF0302 family
GO004_02275	COG0723	plastoquinol--plastocyanin reductase activity
GO004_02280	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GO004_02285	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
GO004_02285	COG2010	Cytochrome c
GO004_02290	COG4347	Protein of unknown function (DUF1405)
GO004_02300	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GO004_02305	COG1694	Mazg nucleotide pyrophosphohydrolase
GO004_02310	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
GO004_02315	COG1803	Methylglyoxal synthase
GO004_02320	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GO004_02325	COG0438	transferase activity, transferring glycosyl groups
GO004_02330	COG0617	tRNA 3'-terminal CCA addition
GO004_02335	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
GO004_02335	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
GO004_02340	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
GO004_02345	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
GO004_02350	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
GO004_02355	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
GO004_02355	COG1199	ATP-dependent helicase activity
GO004_02365	COG5353	protein conserved in bacteria
GO004_02370	COG0436	Aminotransferase
GO004_02375	COG0017	Asparaginyl-tRNA synthetase
GO004_02380	COG3935	DnaD domain protein
GO004_02385	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
GO004_02395	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GO004_02395	COG4499	WXG100 protein secretion system (Wss), protein YukC
GO004_02400	COG3331	DNA recombination
GO004_02435	COG0071	Belongs to the small heat shock protein (HSP20) family
GO004_02440	COG2190	(PTS) system
GO004_02445	COG1111	helicase
GO004_02445	COG1205	dead DEAH box helicase
GO004_02450	COG3359	exonuclease
GO004_02465	COG4474	Belongs to the UPF0398 family
GO004_02480	COG0116	Belongs to the methyltransferase superfamily
GO004_02495	COG1199	ATP-dependent helicase activity
GO004_02500	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_02505	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
GO004_02510	COG1609	Transcriptional regulator
GO004_02515	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO004_02520	COG0800	Aldolase
GO004_02530	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
GO004_02535	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GO004_02540	COG2233	PERMEase
GO004_02545	COG3424	synthase
GO004_02550	COG1755	Isoprenylcysteine carboxyl methyltransferase
GO004_02560	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
GO004_02575	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GO004_02585	COG0328	RNA-DNA hybrid ribonuclease activity
GO004_02590	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
GO004_02595	COG0328	RNA-DNA hybrid ribonuclease activity
GO004_02615	COG1278	Cold shock
GO004_02625	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GO004_02630	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
GO004_02635	COG0386	Belongs to the glutathione peroxidase family
GO004_02640	COG1418	mRNA catabolic process
GO004_02645	COG1413	lyase activity
GO004_02650	COG0129	dihydroxy-acid dehydratase activity
GO004_02660	COG2136	Putative SAM-dependent methyltransferase
GO004_02660	COG2521	methyltransferase
GO004_02670	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GO004_02675	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
GO004_02680	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GO004_02685	COG0204	Acyl-transferase
GO004_02690	COG1272	protein, Hemolysin III
GO004_02695	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GO004_02700	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
GO004_02710	COG1999	signal sequence binding
GO004_02715	COG2755	lipolytic protein G-D-S-L family
GO004_02720	COG4698	Protein conserved in bacteria
GO004_02730	COG0534	Mate efflux family protein
GO004_02735	COG1846	Transcriptional regulator
GO004_02740	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GO004_02745	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
GO004_02750	COG1086	Polysaccharide biosynthesis protein
GO004_02755	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
GO004_02760	COG4641	Protein conserved in bacteria
GO004_02775	COG0463	Glycosyl transferase, family 2
GO004_02780	COG0456	acetyltransferase
GO004_02795	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GO004_02800	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GO004_02805	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GO004_02810	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GO004_02815	COG0456	acetyltransferase
GO004_02820	COG1509	lysine 2,3-aminomutase activity
GO004_02830	COG4479	Belongs to the UPF0346 family
GO004_02850	COG0671	phosphoesterase, PA-phosphatase related
GO004_02865	COG0813	purine-nucleoside phosphorylase activity
GO004_02870	COG1876	peptidase activity
GO004_02880	COG2226	methyltransferase
GO004_02885	COG3409	Peptidoglycan-binding domain 1 protein
GO004_02885	COG0793	Belongs to the peptidase S41A family
GO004_02890	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO004_02900	COG0346	lactoylglutathione lyase activity
GO004_02905	COG0400	carboxylic ester hydrolase activity
GO004_02910	COG0778	Nitroreductase
GO004_02915	COG1733	regulation of RNA biosynthetic process
GO004_02920	COG1942	4-Oxalocrotonate Tautomerase
GO004_02925	COG2610	gluconate transmembrane transporter activity
GO004_02940	COG2962	Rard protein
GO004_02950	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GO004_02955	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
GO004_02960	COG1366	Belongs to the anti-sigma-factor antagonist family
GO004_02965	COG0534	Mate efflux family protein
GO004_02970	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GO004_02975	COG1819	glycosyl
GO004_02980	COG0791	NLP P60 protein
GO004_02980	COG1388	LysM domain
GO004_02985	COG2032	superoxide dismutase activity
GO004_02990	COG0714	Associated with various cellular activities
GO004_02995	COG4548	von Willebrand factor, type A
GO004_03000	COG0567	Dehydrogenase, E1 component
GO004_03005	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO004_03010	COG0385	Bile acid
GO004_03015	COG0733	neurotransmitter:sodium symporter activity
GO004_03020	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
GO004_03025	COG1657	PFAM Prenyltransferase squalene oxidase
GO004_03030	COG1012	belongs to the aldehyde dehydrogenase family
GO004_03055	COG0071	Belongs to the small heat shock protein (HSP20) family
GO004_03070	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GO004_03075	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GO004_03085	COG0514	ATP-dependent DNA helicase (RecQ)
GO004_03090	COG1388	LysM domain
GO004_03090	COG3584	3D domain protein
GO004_03095	COG2197	response regulator
GO004_03100	COG4585	Histidine kinase
GO004_03105	COG3239	Fatty acid desaturase
GO004_03110	COG1619	proteins homologs of microcin C7 resistance protein MccF
GO004_03125	COG2322	membrane
GO004_03130	COG0741	lytic transglycosylase activity
GO004_03135	COG0640	Transcriptional regulator
GO004_03145	COG2378	regulation of single-species biofilm formation
GO004_03150	COG3708	Transcriptional regulator
GO004_03155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO004_03160	COG1309	transcriptional regulator
GO004_03165	COG0456	acetyltransferase
GO004_03170	COG0662	Cupin 2, conserved barrel domain protein
GO004_03170	COG2207	Transcriptional regulator
GO004_03175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO004_03180	COG5434	Belongs to the glycosyl hydrolase 28 family
GO004_03185	COG1231	oxidoreductase activity
GO004_03190	COG4282	regulation of fungal-type cell wall biogenesis
GO004_03220	COG2314	TM2 domain
GO004_03225	COG0726	polysaccharide deacetylase
GO004_03230	COG0574	Belongs to the PEP-utilizing enzyme family
GO004_03230	COG3848	Pyruvate phosphate dikinase
GO004_03250	COG2367	Beta-lactamase
GO004_03255	COG0693	protein deglycase activity
GO004_03265	COG0697	spore germination
GO004_03270	COG0583	DNA-binding transcription factor activity
GO004_03275	COG3739	integral membrane protein
GO004_03280	COG3655	Transcriptional regulator
GO004_03290	COG2720	vancomycin resistance protein
GO004_03320	COG2140	Oxalate decarboxylase
GO004_03330	COG2135	peptidase activity
GO004_03335	COG3866	Pectate lyase
GO004_03340	COG3619	membrane
GO004_03345	COG4305	rare lipoprotein A
GO004_03350	COG2368	4-hydroxyphenylacetate
GO004_03355	COG5278	phosphoserine phosphatase activity
GO004_03355	COG0840	transmembrane signaling receptor activity
GO004_03385	COG0243	molybdopterin cofactor binding
GO004_03390	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
GO004_03395	COG1070	Carbohydrate kinase
GO004_03400	COG2814	Major facilitator Superfamily
GO004_03415	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GO004_03420	COG0300	oxidoreductase activity
GO004_03430	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GO004_03435	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GO004_03440	COG0583	DNA-binding transcription factor activity
GO004_03445	COG0070	glutamate synthase
GO004_03445	COG0067	glutamate synthase
GO004_03445	COG0069	glutamate synthase activity
GO004_03450	COG0493	'glutamate synthase
GO004_03455	COG0604	alcohol dehydrogenase
GO004_03460	COG0583	DNA-binding transcription factor activity
GO004_03465	COG0405	Gamma-glutamyltransferase
GO004_03470	COG0166	Belongs to the GPI family
GO004_03475	COG0582	viral genome integration into host DNA
GO004_03490	COG0534	Mate efflux family protein
GO004_03495	COG2017	converts alpha-aldose to the beta-anomer
GO004_03500	COG2027	D-alanyl-D-alanine carboxypeptidase
GO004_03505	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_03510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_03515	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_03520	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_03525	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_03525	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GO004_03535	COG1649	PFAM Uncharacterised BCR, COG1649
GO004_03550	COG1960	acyl-CoA dehydrogenase activity
GO004_03555	COG0318	PFAM AMP-dependent synthetase and ligase
GO004_03560	COG0439	Biotin carboxylase
GO004_03565	COG0511	ligase activity, forming carbon-carbon bonds
GO004_03570	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GO004_03575	COG1024	Enoyl-CoA hydratase
GO004_03580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
GO004_03585	COG2404	hydrolase activity, acting on ester bonds
GO004_03590	COG0586	Pfam SNARE associated Golgi protein
GO004_03595	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GO004_03600	COG2246	polysaccharide biosynthetic process
GO004_03605	COG3507	Belongs to the glycosyl hydrolase 43 family
GO004_03610	COG5520	Belongs to the glycosyl hydrolase 30 family
GO004_03620	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
GO004_03625	COG1115	amino acid carrier protein
GO004_03635	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GO004_03640	COG0187	DNA topoisomerase II activity
GO004_03645	COG1832	CoA-binding protein
GO004_03650	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
GO004_03655	COG4841	protein insertion into membrane
GO004_03665	COG0824	Thioesterase
GO004_03685	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO004_03690	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
GO004_03705	COG0071	Belongs to the small heat shock protein (HSP20) family
GO004_03715	COG4846	Membrane protein involved in cytochrome C biogenesis
GO004_03720	COG2201	protein-glutamate methylesterase activity
GO004_03725	COG0785	Cytochrome C biogenesis protein
GO004_03735	COG3763	UPF0154 protein
GO004_03745	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
GO004_03750	COG4224	UPF0291 protein
GO004_03755	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
GO004_03760	COG1388	LysM domain
GO004_03765	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
GO004_03770	COG0346	lactoylglutathione lyase activity
GO004_03780	COG4195	phage-related replication protein
GO004_03810	COG0531	amino acid
GO004_03825	COG3832	glyoxalase III activity
GO004_03835	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GO004_03875	COG0756	dUTP diphosphatase activity
GO004_03885	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GO004_03890	COG2814	Major facilitator Superfamily
GO004_03895	COG1525	nuclease
GO004_03905	COG1070	Carbohydrate kinase
GO004_03910	COG2115	Belongs to the xylose isomerase family
GO004_03915	COG1940	carbohydrate kinase activity
GO004_03920	COG3507	Belongs to the glycosyl hydrolase 43 family
GO004_03925	COG2211	Major facilitator Superfamily
GO004_03935	COG0135	phosphoribosylanthranilate isomerase activity
GO004_03950	COG3655	Transcriptional regulator
GO004_03965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO004_03985	COG0463	Glycosyl transferase, family 2
GO004_04020	COG0174	glutamine synthetase
GO004_04025	COG0789	Transcriptional regulator
GO004_04030	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
GO004_04035	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
GO004_04055	COG3331	DNA recombination
GO004_04105	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GO004_04135	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GO004_04165	COG0756	dUTP diphosphatase activity
GO004_04175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO004_04200	COG1372	Participates in initiation and elongation during chromosome replication
GO004_04200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GO004_04205	COG1780	Probably involved in ribonucleotide reductase function
GO004_04305	COG0270	DNA (cytosine-5-)-methyltransferase activity
GO004_04320	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GO004_04345	COG3584	3D domain protein
GO004_04350	COG0587	DNA-directed DNA polymerase activity
GO004_04355	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GO004_04360	COG0358	DNA primase activity
GO004_04365	COG0305	Participates in initiation and elongation during chromosome replication
GO004_04375	COG2887	Belongs to the helicase family. UvrD subfamily
GO004_04420	COG2135	peptidase activity
GO004_04425	COG1793	dna ligase
GO004_04505	COG3655	Transcriptional regulator
GO004_04520	COG0582	viral genome integration into host DNA
GO004_04645	COG0582	viral genome integration into host DNA
GO004_04685	COG2433	Pfam Transposase IS66
GO004_04695	COG5434	Belongs to the glycosyl hydrolase 28 family
GO004_04700	COG3409	Peptidoglycan-binding domain 1 protein
GO004_04700	COG5632	N-Acetylmuramoyl-L-alanine amidase
GO004_04715	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GO004_04720	COG0463	Glycosyl transferase, family 2
GO004_04725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO004_04730	COG2274	protein secretion by the type I secretion system
GO004_04730	COG3271	cysteine-type peptidase activity
GO004_04745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
GO004_04760	COG0457	Tetratricopeptide repeat
GO004_04780	COG5444	nuclease activity
GO004_04785	COG4282	regulation of fungal-type cell wall biogenesis
GO004_04795	COG1525	nuclease
GO004_04810	COG0464	growth
GO004_04815	COG0860	N-Acetylmuramoyl-L-alanine amidase
GO004_04820	COG4112	unkown
GO004_04825	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GO004_04830	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
GO004_04835	COG1780	Probably involved in ribonucleotide reductase function
GO004_04850	COG1923	regulation of RNA biosynthetic process
GO004_04855	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
GO004_04870	COG2076	Multidrug Resistance protein
GO004_04875	COG2076	Multidrug Resistance protein
GO004_04880	COG1764	response to oxidative stress
GO004_04885	COG4195	phage-related replication protein
GO004_04895	COG1404	Belongs to the peptidase S8 family
GO004_04900	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO004_04910	COG2124	cytochrome p450
GO004_04915	COG3321	synthase
GO004_04915	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
GO004_04915	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
GO004_04915	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO004_04920	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_04920	COG4221	oxidoreductase activity
GO004_04920	COG3321	synthase
GO004_04920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_04925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO004_04925	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_04925	COG3321	synthase
GO004_04925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_04925	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO004_04930	COG0300	oxidoreductase activity
GO004_04930	COG4221	oxidoreductase activity
GO004_04930	COG3321	synthase
GO004_04930	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO004_04935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_04935	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_04935	COG0318	PFAM AMP-dependent synthetase and ligase
GO004_04935	COG3321	synthase
GO004_04935	COG0300	oxidoreductase activity
GO004_04940	COG1024	Enoyl-CoA hydratase
GO004_04945	COG1024	Enoyl-CoA hydratase
GO004_04950	COG3425	synthase
GO004_04955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GO004_04960	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO004_04965	COG2070	2-Nitropropane dioxygenase
GO004_04965	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GO004_04970	COG3321	synthase
GO004_04975	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GO004_04985	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO004_04990	COG3226	Transcriptional regulator
GO004_05005	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
GO004_05010	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
GO004_05020	COG4550	Control of competence regulator ComK, YlbF/YmcA
GO004_05025	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
GO004_05030	COG0156	8-amino-7-oxononanoate synthase activity
GO004_05035	COG1063	alcohol dehydrogenase
GO004_05040	COG2359	stage V sporulation protein S
GO004_05045	COG1692	metallophosphoesterase
GO004_05050	COG1418	mRNA catabolic process
GO004_05055	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GO004_05060	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
GO004_05065	COG1546	Belongs to the CinA family
GO004_05065	COG1058	Belongs to the CinA family
GO004_05070	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
GO004_05075	COG1426	Protein conserved in bacteria
GO004_05090	COG0300	oxidoreductase activity
GO004_05095	COG0612	Peptidase, M16
GO004_05100	COG0612	Peptidase, M16
GO004_05105	COG2814	Major facilitator Superfamily
GO004_05110	COG2188	Transcriptional regulator
GO004_05115	COG4980	gas vesicle protein
GO004_05115	COG1674	ftsk spoiiie
GO004_05125	COG0740	serine-type endopeptidase activity
GO004_05130	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GO004_05135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GO004_05140	COG0527	aspartate kinase activity
GO004_05145	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
GO004_05150	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GO004_05155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GO004_05160	COG1873	PFAM PRC-barrel domain
GO004_05165	COG0612	Peptidase, M16
GO004_05170	COG0726	polysaccharide deacetylase
GO004_05175	COG1185	polyribonucleotide nucleotidyltransferase activity
GO004_05180	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
GO004_05185	COG0196	riboflavin kinase activity
GO004_05190	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
GO004_05195	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
GO004_05200	COG1550	Protein conserved in bacteria
GO004_05205	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
GO004_05210	COG1358	cellular component organization or biogenesis
GO004_05215	COG2740	Nucleic-acid-binding protein implicated in transcription termination
GO004_05220	COG0195	Participates in both transcription termination and antitermination
GO004_05225	COG0779	Required for maturation of 30S ribosomal subunits
GO004_05230	COG2176	DNA-directed DNA polymerase activity
GO004_05235	COG0442	prolyl-tRNA aminoacylation
GO004_05240	COG0750	zinc metalloprotease
GO004_05245	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
GO004_05250	COG4589	Belongs to the CDS family
GO004_05255	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
GO004_05260	COG0233	cytoplasmic translational termination
GO004_05265	COG0528	UMP kinase activity
GO004_05270	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
GO004_05275	COG0052	Belongs to the universal ribosomal protein uS2 family
GO004_05285	COG1191	sigma factor activity
GO004_05290	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
GO004_05295	COG1776	CheC inhibitor of MCP methylation
GO004_05300	COG0835	chemotaxis
GO004_05305	COG0643	Histidine kinase
GO004_05305	COG2198	Histidine kinase
GO004_05310	COG2201	protein-glutamate methylesterase activity
GO004_05315	COG0455	bacterial-type flagellum organization
GO004_05320	COG1419	protein localization to endoplasmic reticulum
GO004_05325	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GO004_05330	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
GO004_05335	COG1684	flagellar biosynthetic protein fliR
GO004_05340	COG1987	bacterial-type flagellum assembly
GO004_05345	COG1338	Plays a role in the flagellum-specific transport system
GO004_05350	COG3190	flagellar
GO004_05360	COG1776	CheC inhibitor of MCP methylation
GO004_05360	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GO004_05365	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GO004_05370	COG1580	Controls the rotational direction of flagella during chemotaxis
GO004_05375	COG1582	Flagellar protein (FlbD)
GO004_05380	COG4786	Flagellar basal body rod
GO004_05385	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
GO004_05390	COG3144	bacterial-type flagellum assembly
GO004_05395	COG3334	PFAM MgtE intracellular
GO004_05400	COG2882	bacterial-type flagellum organization
GO004_05405	COG1157	protein secretion by the type III secretion system
GO004_05410	COG1317	bacterial-type flagellum organization
GO004_05415	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
GO004_05420	COG1766	The M ring may be actively involved in energy transduction
GO004_05425	COG1677	Flagellar hook-basal body complex protein FliE
GO004_05430	COG1558	bacterial-type flagellum-dependent cell motility
GO004_05435	COG1815	bacterial-type flagellum-dependent cell motility
GO004_05440	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GO004_05445	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
GO004_05450	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
GO004_05455	COG4974	Belongs to the 'phage' integrase family
GO004_05460	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
GO004_05465	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GO004_05470	COG0758	DNA mediated transformation
GO004_05475	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
GO004_05480	COG0045	succinate-CoA ligase (ADP-forming) activity
GO004_05485	COG2257	FlhB HrpN YscU SpaS Family
GO004_05495	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GO004_05500	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
GO004_05505	COG0335	large ribosomal subunit rRNA binding
GO004_05510	COG0336	Belongs to the RNA methyltransferase TrmD family
GO004_05515	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
GO004_05525	COG1837	Belongs to the UPF0109 family
GO004_05530	COG0228	four-way junction DNA binding
GO004_05535	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
GO004_05540	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
GO004_05550	COG0552	protein localization to endoplasmic reticulum
GO004_05555	COG1196	nuclear chromosome segregation
GO004_05560	COG0571	ribonuclease III activity
GO004_05570	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_05575	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
GO004_05580	COG0416	fatty acid biosynthetic process
GO004_05585	COG1349	DNA-binding transcription factor activity
GO004_05585	COG2050	protein possibly involved in aromatic compounds catabolism
GO004_05590	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
GO004_05595	COG1760	l-serine dehydratase
GO004_05600	COG1760	l-serine dehydratase
GO004_05605	COG1461	Dihydroxyacetone kinase
GO004_05610	COG1302	Protein conserved in bacteria
GO004_05615	COG0227	Belongs to the bacterial ribosomal protein bL28 family
GO004_05625	COG1564	THIamine pyrophosphokinase
GO004_05630	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
GO004_05635	COG1162	GTPase activity
GO004_05640	COG0515	serine threonine protein kinase
GO004_05640	COG2815	serine threonine protein kinase
GO004_05645	COG0631	protein serine/threonine phosphatase activity
GO004_05650	COG0820	rRNA (adenine-C2-)-methyltransferase activity
GO004_05655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
GO004_05655	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
GO004_05660	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
GO004_05665	COG0242	peptide deformylase activity
GO004_05670	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GO004_05675	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
GO004_05680	COG1758	RNA polymerase activity
GO004_05685	COG0194	GDP metabolic process
GO004_05695	COG1561	YicC-like family, N-terminal region
GO004_05700	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GO004_05705	COG1293	RNA-binding protein homologous to eukaryotic snRNP
GO004_05710	COG1648	precorrin-2 dehydrogenase activity
GO004_05715	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
GO004_05720	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GO004_05725	COG0529	Catalyzes the synthesis of activated sulfate
GO004_05730	COG2046	Belongs to the sulfate adenylyltransferase family
GO004_05735	COG0306	phosphate transporter
GO004_05740	COG0175	sulfate reduction
GO004_05745	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
GO004_05750	COG0284	orotidine-5'-phosphate decarboxylase activity
GO004_05755	COG0167	dihydroorotate dehydrogenase activity
GO004_05760	COG0543	2 iron, 2 sulfur cluster binding
GO004_05765	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO004_05770	COG0505	Belongs to the CarA family
GO004_05775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO004_05780	COG0540	Belongs to the ATCase OTCase family
GO004_05785	COG2233	PERMEase
GO004_05790	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
GO004_05795	COG0564	pseudouridine synthase activity
GO004_05800	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
GO004_05805	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GO004_05810	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
GO004_05815	COG3599	regulation of cell shape
GO004_05820	COG2302	S4 RNA-binding domain
GO004_05825	COG0762	integral membrane protein
GO004_05830	COG1799	cell septum assembly
GO004_05835	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
GO004_05840	COG1496	oxidoreductase activity
GO004_05845	COG1873	PFAM PRC-barrel domain
GO004_05850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GO004_05855	COG1119	ATPase activity
GO004_05860	COG1191	sigma factor activity
GO004_05865	COG1191	sigma factor activity
GO004_05875	COG1404	Belongs to the peptidase S8 family
GO004_05875	COG4412	M6 family metalloprotease domain protein
GO004_05880	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
GO004_05885	COG0849	cell division
GO004_05890	COG3856	small basic protein
GO004_05895	COG3879	Bacterial protein of unknown function (DUF881)
GO004_05900	COG3879	Bacterial protein of unknown function (DUF881)
GO004_05905	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
GO004_05910	COG0812	UDP-N-acetylmuramate dehydrogenase activity
GO004_05915	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GO004_05920	COG0772	Belongs to the SEDS family
GO004_05925	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GO004_05930	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GO004_05935	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
GO004_05940	COG0768	penicillin binding
GO004_05945	COG0768	penicillin binding
GO004_05950	COG4839	cell division protein FtsL
GO004_05955	COG0275	rRNA processing
GO004_05960	COG2001	Belongs to the MraZ family
GO004_05965	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
GO004_05970	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GO004_05975	COG0454	-acetyltransferase
GO004_05990	COG1399	metal-binding, possibly nucleic acid-binding protein
GO004_06000	COG1323	Belongs to the UPF0348 family
GO004_06005	COG3480	Lon protease (S16) C-terminal proteolytic domain
GO004_06010	COG1752	Esterase of the alpha-beta hydrolase superfamily
GO004_06015	COG3314	Sporulation integral membrane protein YlbJ
GO004_06020	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
GO004_06025	COG0742	ribosomal rna small subunit methyltransferase
GO004_06030	COG4471	UPF0298 protein
GO004_06035	COG3679	Belongs to the UPF0342 family
GO004_06050	COG2340	Cysteine-rich secretory protein family
GO004_06055	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
GO004_06065	COG3336	cytochrome c oxidase
GO004_06070	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GO004_06075	COG1845	cytochrome c oxidase, subunit III
GO004_06080	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GO004_06085	COG2010	Cytochrome c
GO004_06085	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GO004_06090	COG0109	protoheme IX farnesyltransferase activity
GO004_06095	COG1612	heme a metabolic process
GO004_06100	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
GO004_06105	COG0772	Belongs to the SEDS family
GO004_06110	COG4838	Belongs to the UPF0358 family
GO004_06115	COG2066	Belongs to the glutaminase family
GO004_06120	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GO004_06125	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
GO004_06135	COG4896	Protein conserved in bacteria
GO004_06145	COG1217	gtp-binding protein TYPA
GO004_06165	COG1595	DNA-templated transcription, initiation
GO004_06185	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
GO004_06195	COG0483	inositol monophosphate 1-phosphatase activity
GO004_06205	COG4493	Belongs to the UPF0637 family
GO004_06210	COG4476	Belongs to the UPF0223 family
GO004_06215	COG1982	Orn Lys Arg decarboxylase major
GO004_06225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO004_06230	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GO004_06235	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO004_06240	COG0022	dehydrogenase e1 component
GO004_06245	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO004_06250	COG0497	DNA recombination
GO004_06260	COG0242	peptide deformylase activity
GO004_06265	COG0561	phosphatase activity
GO004_06270	COG5503	Protein of unknown function (DUF1447)
GO004_06275	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
GO004_06280	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GO004_06285	COG0569	domain protein
GO004_06290	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
GO004_06290	COG2105	PFAM AIG2 family protein
GO004_06295	COG3852	Histidine kinase
GO004_06300	COG2002	toxin-antitoxin pair type II binding
GO004_06305	COG1077	Cell shape determining protein MreB Mrl
GO004_06315	COG2309	aminopeptidase activity
GO004_06320	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
GO004_06325	COG0488	(ABC) transporter
GO004_06335	COG0681	Belongs to the peptidase S26 family
GO004_06340	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO004_06340	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO004_06340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO004_06345	COG1105	Belongs to the carbohydrate kinase PfkB family
GO004_06350	COG1349	DNA-binding transcription factor activity
GO004_06355	COG0577	efflux transmembrane transporter activity
GO004_06360	COG1136	(ABC) transporter
GO004_06365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO004_06375	COG1132	(ABC) transporter
GO004_06380	COG1132	(ABC) transporter
GO004_06385	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
GO004_06390	COG0314	molybdopterin synthase activity
GO004_06395	COG1763	Mo-molybdopterin cofactor biosynthetic process
GO004_06400	COG0303	'Molybdopterin
GO004_06405	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GO004_06410	COG0746	molybdenum cofactor guanylyltransferase activity
GO004_06425	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO004_06430	COG0450	alkyl hydroperoxide reductase
GO004_06435	COG0668	transmembrane transport
GO004_06445	COG1473	amidohydrolase
GO004_06450	COG2171	N-acyltransferase activity
GO004_06455	COG0716	FMN binding
GO004_06465	COG0716	FMN binding
GO004_06470	COG0583	DNA-binding transcription factor activity
GO004_06475	COG0517	IMP dehydrogenase activity
GO004_06485	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
GO004_06490	COG4703	Protein of unknown function (DUF1797)
GO004_06495	COG2200	EAL domain
GO004_06500	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_06505	COG1408	metallophosphoesterase
GO004_06510	COG1376	ErfK ybiS ycfS ynhG family protein
GO004_06515	COG2814	Major facilitator Superfamily
GO004_06525	COG0835	chemotaxis
GO004_06525	COG0784	Response regulator, receiver
GO004_06535	COG0436	Aminotransferase
GO004_06540	COG4191	Histidine kinase
GO004_06545	COG0768	penicillin binding
GO004_06550	COG2340	Cysteine-rich secretory protein family
GO004_06555	COG2084	Dehydrogenase
GO004_06560	COG0840	transmembrane signaling receptor activity
GO004_06565	COG0456	acetyltransferase
GO004_06570	COG1533	DNA photolyase activity
GO004_06580	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
GO004_06585	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO004_06590	COG2190	(PTS) system
GO004_06590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO004_06590	COG1263	PTS System
GO004_06595	COG3711	transcriptional antiterminator
GO004_06600	COG1609	Transcriptional regulator
GO004_06605	COG0006	proline dipeptidase activity
GO004_06615	COG2217	Heavy metal translocating P-type atpase
GO004_06620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO004_06625	COG2244	polysaccharide biosynthetic process
GO004_06630	COG3773	Cell wall hydrolase
GO004_06640	COG4873	Protein conserved in bacteria
GO004_06650	COG3858	chitin binding
GO004_06655	COG1388	LysM domain
GO004_06660	COG1388	LysM domain
GO004_06660	COG4641	Protein conserved in bacteria
GO004_06665	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_06670	COG1733	regulation of RNA biosynthetic process
GO004_06675	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
GO004_06680	COG0602	queuosine metabolic process
GO004_06685	COG0720	synthase
GO004_06690	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
GO004_06695	COG3949	Membrane
GO004_06700	COG0542	response to heat
GO004_06705	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GO004_06710	COG1360	Flagellar Motor Protein
GO004_06715	COG1846	Transcriptional regulator
GO004_06720	COG3852	Histidine kinase
GO004_06735	COG3339	Conserved Protein
GO004_06740	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
GO004_06745	COG0235	Class ii aldolase
GO004_06750	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
GO004_06755	COG1850	ribulose-bisphosphate carboxylase activity
GO004_06760	COG0436	Aminotransferase
GO004_06765	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GO004_06770	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
GO004_06775	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
GO004_06785	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GO004_06790	COG5002	protein histidine kinase activity
GO004_06795	COG3594	Acyltransferase
GO004_06810	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GO004_06815	COG0501	Belongs to the peptidase M48B family
GO004_06835	COG1191	sigma factor activity
GO004_06840	COG0861	Integral membrane protein TerC family
GO004_06845	COG0586	Pfam SNARE associated Golgi protein
GO004_06850	COG3300	MHYT domain
GO004_06850	COG5001	Diguanylate cyclase
GO004_06855	COG3300	MHYT domain
GO004_06855	COG5001	Diguanylate cyclase
GO004_06860	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
GO004_06865	COG3285	dna ligase
GO004_06865	COG1793	dna ligase
GO004_06870	COG0463	Glycosyl transferase, family 2
GO004_06880	COG1408	metallophosphoesterase
GO004_06885	COG0726	polysaccharide deacetylase
GO004_06890	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
GO004_06895	COG1846	Transcriptional regulator
GO004_06910	COG0789	Transcriptional regulator
GO004_06915	COG2239	Acts as a magnesium transporter
GO004_06930	COG3212	peptidase
GO004_06935	COG3212	peptidase
GO004_06940	COG3850	Histidine kinase
GO004_06940	COG5002	protein histidine kinase activity
GO004_06945	COG0745	RESPONSE REGULATOR receiver
GO004_06955	COG4721	ABC-type cobalt transport system, permease component
GO004_06960	COG1122	ATPase activity
GO004_06965	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GO004_06970	COG1366	Belongs to the anti-sigma-factor antagonist family
GO004_06975	COG1404	Belongs to the peptidase S8 family
GO004_06980	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GO004_06985	COG0590	tRNA wobble adenosine to inosine editing
GO004_06995	COG1764	response to oxidative stress
GO004_07000	COG1846	Transcriptional regulator
GO004_07005	COG1764	response to oxidative stress
GO004_07010	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
GO004_07015	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
GO004_07020	COG0788	formyltetrahydrofolate deformylase activity
GO004_07025	COG2076	Multidrug Resistance protein
GO004_07030	COG2076	Multidrug Resistance protein
GO004_07035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO004_07040	COG2318	DinB family
GO004_07045	COG2323	membrane
GO004_07055	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
GO004_07055	COG1017	nitric oxide dioxygenase activity
GO004_07060	COG1607	acyl-coa hydrolase
GO004_07065	COG1834	amidinotransferase
GO004_07070	COG2706	6-phosphogluconolactonase activity
GO004_07075	COG4608	Belongs to the ABC transporter superfamily
GO004_07080	COG0791	NLP P60 protein
GO004_07085	COG4948	Mandelate Racemase Muconate Lactonizing
GO004_07090	COG1619	proteins homologs of microcin C7 resistance protein MccF
GO004_07095	COG4166	transmembrane transport
GO004_07100	COG0444	Belongs to the ABC transporter superfamily
GO004_07105	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO004_07110	COG0601	transmembrane transport
GO004_07115	COG2362	D-Aminopeptidase
GO004_07120	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
GO004_07125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GO004_07135	COG0463	Glycosyl transferase, family 2
GO004_07140	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GO004_07145	COG0346	lactoylglutathione lyase activity
GO004_07150	COG0531	amino acid
GO004_07155	COG1392	Phosphate transport regulator
GO004_07160	COG0306	phosphate transporter
GO004_07180	COG5632	N-Acetylmuramoyl-L-alanine amidase
GO004_07180	COG3409	Peptidoglycan-binding domain 1 protein
GO004_07220	COG3778	Protein conserved in bacteria
GO004_07225	COG3299	homolog of phage Mu protein gp47
GO004_07230	COG3628	GPW Gp25 family protein
GO004_07240	COG4193	domain, Protein
GO004_07245	COG1652	LysM domain
GO004_07250	COG3953	SLT domain
GO004_07250	COG5412	phage tail tape measure protein
GO004_07300	COG4653	Phage capsid family
GO004_07305	COG0338	D12 class N6 adenine-specific DNA methyltransferase
GO004_07310	COG5518	Phage portal protein
GO004_07315	COG1783	phage Terminase large subunit
GO004_07320	COG5484	DNA packaging
GO004_07320	COG3728	DNA packaging
GO004_07325	COG1595	DNA-templated transcription, initiation
GO004_07345	COG1484	DNA-dependent DNA replication
GO004_07350	COG1522	sequence-specific DNA binding
GO004_07360	COG1396	sequence-specific DNA binding
GO004_07365	COG2856	Zn peptidase
GO004_07370	COG3546	catalase activity
GO004_07375	COG4195	phage-related replication protein
GO004_07385	COG1388	LysM domain
GO004_07385	COG3409	Peptidoglycan-binding domain 1 protein
GO004_07385	COG5632	N-Acetylmuramoyl-L-alanine amidase
GO004_07390	COG2350	Protein conserved in bacteria
GO004_07400	COG0457	Tetratricopeptide repeat
GO004_07405	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GO004_07410	COG2318	DinB family
GO004_07415	COG0730	response to heat
GO004_07420	COG2721	sulfolactate sulfo-lyase activity
GO004_07425	COG0246	Mannitol dehydrogenase
GO004_07430	COG1609	Transcriptional regulator
GO004_07435	COG2271	Major facilitator Superfamily
GO004_07440	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_07445	COG1312	Catalyzes the dehydration of D-mannonate
GO004_07450	COG1063	alcohol dehydrogenase
GO004_07455	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
GO004_07460	COG2211	Major facilitator Superfamily
GO004_07465	COG1904	glucuronate isomerase
GO004_07470	COG1252	NADH dehydrogenase
GO004_07480	COG4297	protein containing double-stranded beta helix domain
GO004_07485	COG0697	spore germination
GO004_07490	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
GO004_07495	COG0390	transport system, permease component
GO004_07500	COG1587	Uroporphyrinogen-III synthase
GO004_07510	COG1819	glycosyl
GO004_07515	COG2124	cytochrome p450
GO004_07525	COG1051	belongs to the nudix hydrolase family
GO004_07535	COG2427	Protein of unknown function (DUF1641)
GO004_07540	COG3383	formate dehydrogenase (NAD+) activity
GO004_07550	COG2205	protein histidine kinase activity
GO004_07555	COG5504	Zn-dependent protease
GO004_07570	COG0726	polysaccharide deacetylase
GO004_07580	COG0109	protoheme IX farnesyltransferase activity
GO004_07595	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
GO004_07605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO004_07615	COG1482	cell wall glycoprotein biosynthetic process
GO004_07620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO004_07620	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO004_07620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
GO004_07625	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO004_07625	COG3711	transcriptional antiterminator
GO004_07635	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_07640	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GO004_07685	COG5444	nuclease activity
GO004_07700	COG5505	Protein of unknown function (DUF819)
GO004_07705	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO004_07710	COG0626	cystathionine gamma-synthase activity
GO004_07715	COG0626	cystathionine gamma-synthase activity
GO004_07720	COG2382	esterase
GO004_07725	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GO004_07730	COG2153	protein acetylation
GO004_07740	COG0210	DNA helicase
GO004_07795	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
GO004_07800	COG0351	phosphomethylpyrimidine kinase
GO004_07805	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
GO004_07810	COG2022	thiamine diphosphate biosynthetic process
GO004_07815	COG2104	thiamine diphosphate biosynthetic process
GO004_07820	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO004_07825	COG0352	thiamine-phosphate diphosphorylase activity
GO004_07830	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
GO004_07835	COG0475	glutathione-regulated potassium exporter activity
GO004_07835	COG0569	domain protein
GO004_07840	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
GO004_07845	COG0564	pseudouridine synthase activity
GO004_07850	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GO004_07855	COG2357	RelA SpoT domain protein
GO004_07865	COG4116	CYTH
GO004_07870	COG0741	lytic transglycosylase activity
GO004_07875	COG2346	COG2346, Truncated hemoglobins
GO004_07880	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GO004_07890	COG1164	Oligoendopeptidase f
GO004_07895	COG4469	Competence protein
GO004_07905	COG4862	establishment of competence for transformation
GO004_07915	COG0861	Integral membrane protein TerC family
GO004_07920	COG1393	Belongs to the ArsC family
GO004_07925	COG0456	acetyltransferase
GO004_07930	COG2814	Major facilitator Superfamily
GO004_07935	COG4608	Belongs to the ABC transporter superfamily
GO004_07940	COG0444	Belongs to the ABC transporter superfamily
GO004_07945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO004_07950	COG0601	transmembrane transport
GO004_07955	COG4166	transmembrane transport
GO004_07960	COG0180	Tryptophanyl-tRNA synthetase
GO004_07970	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
GO004_07975	COG0601	transmembrane transport
GO004_07985	COG4608	Belongs to the ABC transporter superfamily
GO004_07990	COG0444	Belongs to the ABC transporter superfamily
GO004_07995	COG5504	Zn-dependent protease
GO004_08000	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
GO004_08005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GO004_08020	COG1744	ABC transporter substrate-binding protein PnrA-like
GO004_08030	COG2267	carboxylic ester hydrolase activity
GO004_08045	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
GO004_08050	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
GO004_08055	COG0505	Belongs to the CarA family
GO004_08060	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GO004_08070	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
GO004_08075	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
GO004_08080	COG2271	Major facilitator Superfamily
GO004_08085	COG0277	FAD linked oxidase domain protein
GO004_08095	COG2151	metal-sulfur cluster biosynthetic enzyme
GO004_08100	COG1073	alpha beta
GO004_08105	COG0561	phosphatase activity
GO004_08120	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GO004_08125	COG1307	EDD domain protein, DegV family
GO004_08130	COG3227	Zinc metalloprotease (Elastase)
GO004_08145	COG1695	Transcriptional regulator
GO004_08165	COG2996	Protein conserved in bacteria
GO004_08170	COG1666	GTP binding
GO004_08175	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
GO004_08175	COG0646	methionine synthase
GO004_08180	COG2153	protein acetylation
GO004_08185	COG0454	-acetyltransferase
GO004_08190	COG2814	Major facilitator Superfamily
GO004_08195	COG4948	Mandelate Racemase Muconate Lactonizing
GO004_08200	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GO004_08205	COG1809	phosphosulfolactate synthase activity
GO004_08210	COG2045	Belongs to the ComB family
GO004_08215	COG0175	sulfate reduction
GO004_08220	COG2046	Belongs to the sulfate adenylyltransferase family
GO004_08225	COG0529	Catalyzes the synthesis of activated sulfate
GO004_08230	COG2267	carboxylic ester hydrolase activity
GO004_08235	COG1357	PFAM Pentapeptide repeats (8 copies)
GO004_08240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO004_08245	COG1279	arginine transmembrane transporter activity
GO004_08250	COG2318	DinB family
GO004_08255	COG0673	inositol 2-dehydrogenase activity
GO004_08260	COG1609	Transcriptional regulator
GO004_08265	COG2207	Transcriptional regulator
GO004_08265	COG1917	Cupin 2, conserved barrel domain protein
GO004_08270	COG0534	Mate efflux family protein
GO004_08275	COG1562	ergosterol biosynthetic process
GO004_08280	COG2318	DinB family
GO004_08285	COG0367	asparagine synthase
GO004_08295	COG1404	Belongs to the peptidase S8 family
GO004_08305	COG0179	Fumarylacetoacetate (FAA) hydrolase
GO004_08310	COG5337	Spore coat protein CotH
GO004_08350	COG1403	HNH endonuclease
GO004_08355	COG0419	ATPase involved in DNA repair
GO004_08360	COG0420	3'-5' exonuclease activity
GO004_08365	COG1074	ATP-dependent DNA helicase activity
GO004_08370	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
GO004_08375	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
GO004_08385	COG4533	DNA binding
GO004_08390	COG2814	Major facilitator Superfamily
GO004_08390	COG0477	Major facilitator Superfamily
GO004_08395	COG3180	Ammonia monooxygenase
GO004_08400	COG1609	Transcriptional regulator
GO004_08405	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GO004_08410	COG0561	phosphatase activity
GO004_08415	COG0673	inositol 2-dehydrogenase activity
GO004_08420	COG0738	Major facilitator superfamily
GO004_08425	COG1846	Transcriptional regulator
GO004_08430	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO004_08435	COG0681	Belongs to the peptidase S26 family
GO004_08440	COG0398	Pfam SNARE associated Golgi protein
GO004_08455	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO004_08465	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_08470	COG4903	ComK protein
GO004_08480	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_08485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO004_08485	COG0723	plastoquinol--plastocyanin reductase activity
GO004_08490	COG0840	transmembrane signaling receptor activity
GO004_08495	COG1268	BioY protein
GO004_08500	COG0318	PFAM AMP-dependent synthetase and ligase
GO004_08505	COG0183	Belongs to the thiolase family
GO004_08510	COG0406	alpha-ribazole phosphatase activity
GO004_08515	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GO004_08520	COG0604	alcohol dehydrogenase
GO004_08525	COG0456	acetyltransferase
GO004_08535	COG0501	Belongs to the peptidase M48B family
GO004_08545	COG0318	PFAM AMP-dependent synthetase and ligase
GO004_08550	COG0702	epimerase
GO004_08555	COG0095	Lipoate-protein ligase
GO004_08560	COG1234	tRNA 3'-trailer cleavage
GO004_08570	COG1301	dicarboxylic acid transport
GO004_08575	COG4405	Protein conserved in bacteria
GO004_08580	COG1363	Peptidase, m42
GO004_08590	COG4377	Putative membrane peptidase family (DUF2324)
GO004_08595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
GO004_08600	COG1511	domain protein
GO004_08605	COG1309	transcriptional regulator
GO004_08610	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
GO004_08615	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
GO004_08620	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
GO004_08625	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GO004_08630	COG2329	Antibiotic biosynthesis monooxygenase
GO004_08640	COG3069	C4-dicarboxylate transmembrane transporter activity
GO004_08645	COG1473	amidohydrolase
GO004_08655	COG4473	ABC transporter
GO004_08660	COG1131	(ABC) transporter
GO004_08665	COG0537	adenosine 5'-monophosphoramidase activity
GO004_08670	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
GO004_08685	COG4980	gas vesicle protein
GO004_08690	COG1846	Transcriptional regulator
GO004_08720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GO004_08730	COG3481	metal-dependent phosphohydrolase, HD sub domain
GO004_08735	COG4717	serine-type aminopeptidase activity
GO004_08740	COG0420	3'-5' exonuclease activity
GO004_08750	COG4152	abc transporter atp-binding protein
GO004_08760	COG1024	Enoyl-CoA hydratase
GO004_08770	COG0490	domain, Protein
GO004_08775	COG0475	glutathione-regulated potassium exporter activity
GO004_08780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
GO004_08785	COG0561	phosphatase activity
GO004_08790	COG4335	DNA alkylation repair
GO004_08795	COG3679	Belongs to the UPF0342 family
GO004_08800	COG4399	Belongs to the UPF0754 family
GO004_08805	COG0189	ligase activity
GO004_08810	COG0189	ligase activity
GO004_08830	COG0702	epimerase
GO004_08835	COG1132	(ABC) transporter
GO004_08840	COG1132	(ABC) transporter
GO004_08850	COG0589	response to stress
GO004_08855	COG1757	Na H antiporter
GO004_08860	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GO004_08865	COG0726	polysaccharide deacetylase
GO004_08870	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
GO004_08875	COG0668	transmembrane transport
GO004_08885	COG0584	glycerophosphoryl diester phosphodiesterase
GO004_08890	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GO004_08895	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
GO004_08900	COG1253	flavin adenine dinucleotide binding
GO004_08905	COG0436	Aminotransferase
GO004_08910	COG0789	Transcriptional regulator
GO004_08915	COG1253	flavin adenine dinucleotide binding
GO004_08920	COG0204	Acyl-transferase
GO004_08925	COG0667	Aldo Keto reductase
GO004_08930	COG1595	DNA-templated transcription, initiation
GO004_08945	COG0456	acetyltransferase
GO004_08950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO004_08955	COG0733	neurotransmitter:sodium symporter activity
GO004_08960	COG0531	amino acid
GO004_08965	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_08970	COG0372	Belongs to the citrate synthase family
GO004_08975	COG0583	DNA-binding transcription factor activity
GO004_08980	COG1388	LysM domain
GO004_08980	COG0791	NLP P60 protein
GO004_08985	COG1785	Belongs to the alkaline phosphatase family
GO004_08990	COG2719	SpoVR family
GO004_08995	COG0668	transmembrane transport
GO004_09000	COG1959	2 iron, 2 sulfur cluster binding
GO004_09005	COG1388	LysM domain
GO004_09005	COG0791	NLP P60 protein
GO004_09020	COG0431	NADPH-dependent FMN reductase
GO004_09025	COG2197	response regulator
GO004_09030	COG2203	Gaf domain
GO004_09030	COG4585	Histidine kinase
GO004_09035	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GO004_09040	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
GO004_09045	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
GO004_09050	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
GO004_09055	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
GO004_09060	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GO004_09065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
GO004_09065	COG3153	acetyltransferase
GO004_09070	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO004_09075	COG0517	IMP dehydrogenase activity
GO004_09085	COG0564	pseudouridine synthase activity
GO004_09090	COG3764	Sortase (surface protein transpeptidase)
GO004_09095	COG4085	toxin activity
GO004_09095	COG0737	Belongs to the 5'-nucleotidase family
GO004_09095	COG1525	nuclease
GO004_09100	COG5577	PFAM Coat F domain
GO004_09120	COG1823	symporter activity
GO004_09125	COG3706	GGDEF domain
GO004_09130	COG1464	Belongs to the NlpA lipoprotein family
GO004_09135	COG1278	Cold shock
GO004_09140	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GO004_09145	COG1131	(ABC) transporter
GO004_09150	COG1131	(ABC) transporter
GO004_09155	COG1725	Transcriptional regulator
GO004_09175	COG0655	NAD(P)H dehydrogenase (quinone) activity
GO004_09180	COG2814	Major facilitator Superfamily
GO004_09185	COG1566	PFAM secretion protein HlyD family protein
GO004_09190	COG1846	Transcriptional regulator
GO004_09195	COG2718	Belongs to the UPF0229 family
GO004_09200	COG2766	serine protein kinase
GO004_09205	COG1664	Polymer-forming cytoskeletal
GO004_09210	COG1664	Polymer-forming cytoskeletal
GO004_09215	COG0789	Transcriptional regulator
GO004_09220	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
GO004_09230	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
GO004_09235	COG3382	B3 4 domain protein
GO004_09245	COG1476	TRANSCRIPTIONal
GO004_09255	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
GO004_09265	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO004_09270	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GO004_09275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GO004_09280	COG1116	anion transmembrane transporter activity
GO004_09285	COG0753	catalase activity
GO004_09295	COG0277	FAD linked oxidase domain protein
GO004_09300	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
GO004_09310	COG5577	PFAM Coat F domain
GO004_09320	COG4326	sporulation control protein
GO004_09430	COG0735	belongs to the Fur family
GO004_09435	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
GO004_09440	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GO004_09445	COG4129	membrane
GO004_09450	COG1132	(ABC) transporter
GO004_09455	COG3557	Belongs to the UPF0374 family
GO004_09470	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_09480	COG1194	a g-specific adenine glycosylase
GO004_09485	COG1988	membrane-bound metal-dependent
GO004_09490	COG4485	Bacterial membrane protein, YfhO
GO004_09495	COG0463	Glycosyl transferase, family 2
GO004_09500	COG0596	Alpha beta hydrolase
GO004_09505	COG5658	integral membrane protein
GO004_09525	COG2814	Major facilitator Superfamily
GO004_09535	COG2137	regulation of response to DNA damage stimulus
GO004_09540	COG1090	epimerase
GO004_09555	COG0778	Nitroreductase
GO004_09560	COG0384	phenazine biosynthesis protein PhzF
GO004_09565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO004_09570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO004_09575	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO004_09580	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
GO004_09580	COG0392	lysyltransferase activity
GO004_09585	COG1846	Transcriptional regulator
GO004_09590	COG2814	Major facilitator Superfamily
GO004_09595	COG2318	DinB family
GO004_09600	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
GO004_09605	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GO004_09610	COG1695	Transcriptional regulator
GO004_09615	COG0842	Transport permease protein
GO004_09620	COG0842	Transport permease protein
GO004_09620	COG1511	domain protein
GO004_09625	COG1131	(ABC) transporter
GO004_09630	COG2197	response regulator
GO004_09635	COG4585	Histidine kinase
GO004_09640	COG2514	catechol 2,3-dioxygenase activity
GO004_09645	COG2259	Doxx family
GO004_09650	COG1132	(ABC) transporter
GO004_09655	COG1132	(ABC) transporter
GO004_09660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO004_09660	COG1263	PTS System
GO004_09665	COG1737	Transcriptional regulator
GO004_09670	COG1486	melibiose metabolic process
GO004_09675	COG4842	Belongs to the WXG100 family
GO004_09695	COG1742	UPF0060 membrane protein
GO004_09705	COG3284	Transcriptional regulator
GO004_09710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
GO004_09715	COG0508	dehydrogenase complex catalyzes the overall conversion of
GO004_09720	COG0022	dehydrogenase e1 component
GO004_09725	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
GO004_09730	COG4637	Psort location Cytoplasmic, score
GO004_09735	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GO004_09745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GO004_09750	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GO004_09755	COG0598	Magnesium transport protein CorA
GO004_09760	COG2084	Dehydrogenase
GO004_09765	COG0726	polysaccharide deacetylase
GO004_09775	COG0535	radical SAM domain protein
GO004_09780	COG0668	transmembrane transport
GO004_09790	COG0387	Pfam Sodium calcium exchanger
GO004_09795	COG0477	Major facilitator Superfamily
GO004_09800	COG1295	ribonuclease BN
GO004_09805	COG4980	gas vesicle protein
GO004_09810	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GO004_09815	COG4840	Belongs to the UPF0435 family
GO004_09820	COG2814	Major facilitator Superfamily
GO004_09825	COG0693	protein deglycase activity
GO004_09830	COG0737	Belongs to the 5'-nucleotidase family
GO004_09835	COG0778	Nitroreductase
GO004_09840	COG2188	Transcriptional regulator
GO004_09845	COG0366	Alpha amylase catalytic
GO004_09850	COG1263	PTS System
GO004_09850	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO004_09855	COG0697	spore germination
GO004_09870	COG0531	amino acid
GO004_09875	COG1115	amino acid carrier protein
GO004_09890	COG1368	sulfuric ester hydrolase activity
GO004_09895	COG1263	PTS System
GO004_09895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO004_09900	COG0024	Methionine aminopeptidase
GO004_09920	COG2258	MOSC domain
GO004_09925	COG1254	Belongs to the acylphosphatase family
GO004_09930	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
GO004_09935	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO004_09940	COG2851	Citrate transporter
GO004_09945	COG3181	Tripartite tricarboxylate transporter family receptor
GO004_09950	COG4565	transcriptional regulatory protein
GO004_09955	COG3290	protein histidine kinase activity
GO004_09960	COG0471	metal ion transport
GO004_09965	COG3866	Pectate lyase
GO004_09980	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
GO004_09985	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO004_09990	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO004_09995	COG1120	ATPase activity
GO004_10000	COG1262	PFAM Formylglycine-generating sulfatase enzyme
GO004_10005	COG2211	Major facilitator Superfamily
GO004_10010	COG2130	NADP-dependent
GO004_10015	COG0456	acetyltransferase
GO004_10020	COG0513	Belongs to the DEAD box helicase family
GO004_10025	COG0488	(ABC) transporter
GO004_10035	COG2814	Major facilitator Superfamily
GO004_10040	COG0789	Transcriptional regulator
GO004_10050	COG0488	(ABC) transporter
GO004_10055	COG0840	transmembrane signaling receptor activity
GO004_10060	COG1012	belongs to the aldehyde dehydrogenase family
GO004_10065	COG0531	amino acid
GO004_10070	COG1011	Hydrolase
GO004_10075	COG2223	nitrite transmembrane transporter activity
GO004_10080	COG1442	glycosyl transferase family 8
GO004_10085	COG1216	Glycosyl transferase, family 2
GO004_10090	COG1442	glycosyl transferase family 8
GO004_10095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO004_10100	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
GO004_10105	COG1368	sulfuric ester hydrolase activity
GO004_10110	COG2124	cytochrome p450
GO004_10110	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GO004_10125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
GO004_10130	COG1846	Transcriptional regulator
GO004_10135	COG0697	spore germination
GO004_10140	COG0670	Belongs to the BI1 family
GO004_10145	COG5583	Uncharacterized small protein (DUF2292)
GO004_10160	COG0346	lactoylglutathione lyase activity
GO004_10165	COG2329	Antibiotic biosynthesis monooxygenase
GO004_10170	COG2323	membrane
GO004_10175	COG1486	melibiose metabolic process
GO004_10180	COG0395	ABC-type sugar transport system, permease component
GO004_10185	COG4209	transmembrane transport
GO004_10190	COG1653	transport
GO004_10200	COG1874	Beta-galactosidase
GO004_10205	COG2755	lipolytic protein G-D-S-L family
GO004_10210	COG3401	FG-GAP repeat protein
GO004_10215	COG3401	FG-GAP repeat protein
GO004_10220	COG5578	integral membrane protein
GO004_10230	COG2755	lipolytic protein G-D-S-L family
GO004_10235	COG2207	Transcriptional regulator
GO004_10240	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GO004_10245	COG0395	ABC-type sugar transport system, permease component
GO004_10250	COG1175	transmembrane transport
GO004_10255	COG1653	transport
GO004_10260	COG4753	response regulator
GO004_10260	COG2207	Transcriptional regulator
GO004_10265	COG2972	Histidine kinase
GO004_10270	COG5578	integral membrane protein
GO004_10280	COG0454	-acetyltransferase
GO004_10285	COG3546	catalase activity
GO004_10300	COG0702	epimerase
GO004_10305	COG3631	Ketosteroid isomerase-related protein
GO004_10310	COG1309	transcriptional regulator
GO004_10320	COG0217	transcriptional regulatory protein
GO004_10330	COG0457	Tetratricopeptide repeat
GO004_10335	COG3391	amine dehydrogenase activity
GO004_10340	COG3586	endonuclease activity
GO004_10350	COG5444	nuclease activity
GO004_10365	COG0457	Tetratricopeptide repeat
GO004_10395	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
GO004_10400	COG1597	lipid kinase activity
GO004_10405	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
GO004_10410	COG1309	transcriptional regulator
GO004_10415	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GO004_10420	COG0154	amidase activity
GO004_10425	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
GO004_10430	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO004_10435	COG1285	pathogenesis
GO004_10440	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GO004_10445	COG4851	CamS sex pheromone cAM373 precursor
GO004_10450	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
GO004_10455	COG0210	DNA helicase
GO004_10460	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
GO004_10465	COG0069	glutamate synthase activity
GO004_10470	COG4496	protein, YerC YecD
GO004_10475	COG1470	cell adhesion involved in biofilm formation
GO004_10480	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
GO004_10490	COG0531	amino acid
GO004_10495	COG1522	sequence-specific DNA binding
GO004_10500	COG0151	Belongs to the GarS family
GO004_10505	COG0138	bifunctional purine biosynthesis protein purh
GO004_10510	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
GO004_10515	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
GO004_10520	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
GO004_10525	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GO004_10530	COG0047	phosphoribosylformylglycinamidine synthase activity
GO004_10535	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
GO004_10540	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
GO004_10545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
GO004_10550	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
GO004_10555	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
GO004_10565	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
GO004_10575	COG3064	Membrane
GO004_10580	COG2252	PERMEase
GO004_10595	COG0519	Catalyzes the synthesis of GMP from XMP
GO004_10595	COG0518	GMP synthase (glutamine-hydrolyzing) activity
GO004_10600	COG1305	Transglutaminase-like
GO004_10605	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
GO004_10610	COG0714	Associated with various cellular activities
GO004_10615	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GO004_10625	COG1113	amino acid transport
GO004_10630	COG2132	Multicopper oxidase
GO004_10640	COG2267	carboxylic ester hydrolase activity
GO004_10655	COG0823	Involved in the tonB-independent uptake of proteins
GO004_10660	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
GO004_10665	COG1063	alcohol dehydrogenase
GO004_10670	COG2814	Major facilitator Superfamily
GO004_10680	COG4260	virion core protein, lumpy skin disease virus
GO004_10685	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
GO004_10690	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
GO004_10695	COG1842	Phage shock protein A
GO004_10700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO004_10705	COG2211	Major facilitator Superfamily
GO004_10710	COG1063	alcohol dehydrogenase
GO004_10715	COG0457	Tetratricopeptide repeat
GO004_10720	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
GO004_10740	COG2322	membrane
GO004_10750	COG5444	nuclease activity
GO004_10770	COG0459	protein refolding
GO004_10780	COG1266	CAAX protease self-immunity
GO004_10790	COG0805	protein transport
GO004_10795	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GO004_10800	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
GO004_10805	COG0315	cyclic pyranopterin monophosphate synthase activity
GO004_10810	COG0488	(ABC) transporter
GO004_10815	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
GO004_10820	COG0456	acetyltransferase
GO004_10825	COG1214	PFAM Peptidase M22, glycoprotease
GO004_10830	COG0802	atpase or kinase
GO004_10835	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
GO004_10880	COG4124	Belongs to the glycosyl hydrolase 26 family
GO004_10885	COG1482	cell wall glycoprotein biosynthetic process
GO004_10890	COG1940	carbohydrate kinase activity
GO004_10895	COG2188	Transcriptional regulator
GO004_10900	COG2723	6-phospho-beta-galactosidase activity
GO004_10905	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GO004_10910	COG1447	Phosphotransferase system cellobiose-specific component IIA
GO004_10915	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GO004_10920	COG2814	Major facilitator Superfamily
GO004_10925	COG1388	LysM domain
GO004_10930	COG1078	dGTPase activity
GO004_10935	COG0454	-acetyltransferase
GO004_10945	COG5646	InterPro IPR014922
GO004_10950	COG1785	Belongs to the alkaline phosphatase family
GO004_10960	COG1819	glycosyl
GO004_10965	COG3858	chitin binding
GO004_10965	COG1388	LysM domain
GO004_10970	COG1802	Transcriptional regulator
GO004_10975	COG0730	response to heat
GO004_10980	COG2814	Major facilitator Superfamily
GO004_10985	COG1846	Transcriptional regulator
GO004_10990	COG0778	Nitroreductase
GO004_10995	COG2409	Drug exporters of the RND superfamily
GO004_10995	COG1033	growth of symbiont in host cell
GO004_11000	COG1846	Transcriptional regulator
GO004_11005	COG2318	DinB family
GO004_11010	COG1113	amino acid transport
GO004_11015	COG0488	(ABC) transporter
GO004_11030	COG1309	transcriptional regulator
GO004_11045	COG0071	Belongs to the small heat shock protein (HSP20) family
GO004_11050	COG2323	membrane
GO004_11055	COG2323	membrane
GO004_11070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO004_11075	COG2259	Doxx family
GO004_11080	COG0346	lactoylglutathione lyase activity
GO004_11085	COG0778	Nitroreductase
GO004_11090	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GO004_11095	COG4978	Transcriptional regulator
GO004_11095	COG0789	Transcriptional regulator
GO004_11100	COG1811	Na channel or pump
GO004_11105	COG0596	Alpha beta hydrolase
GO004_11110	COG2409	Drug exporters of the RND superfamily
GO004_11115	COG2197	response regulator
GO004_11120	COG4585	Histidine kinase
GO004_11135	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GO004_11140	COG0640	Transcriptional regulator
GO004_11145	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GO004_11150	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO004_11155	COG0697	spore germination
GO004_11160	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO004_11170	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GO004_11175	COG0640	Transcriptional regulator
GO004_11185	COG1309	transcriptional regulator
GO004_11190	COG2814	Major facilitator Superfamily
GO004_11195	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GO004_11200	COG1733	regulation of RNA biosynthetic process
GO004_11205	COG3545	Serine hydrolase
GO004_11210	COG2030	dehydratase
GO004_11215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO004_11220	COG0697	spore germination
GO004_11225	COG1309	transcriptional regulator
GO004_11230	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO004_11245	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
GO004_11255	COG0477	Major facilitator Superfamily
GO004_11260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO004_11265	COG2207	Transcriptional regulator
GO004_11265	COG3708	Transcriptional regulator
GO004_11270	COG0697	spore germination
GO004_11275	COG2207	Transcriptional regulator
GO004_11275	COG1917	Cupin 2, conserved barrel domain protein
GO004_11280	COG0697	spore germination
GO004_11285	COG1329	Transcriptional regulator
GO004_11290	COG1278	Cold shock
GO004_11295	COG3239	Fatty acid desaturase
GO004_11305	COG1476	TRANSCRIPTIONal
GO004_11310	COG5444	nuclease activity
GO004_11320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO004_11360	COG3091	SprT-like family
GO004_11370	COG2183	response to ionizing radiation
GO004_11375	COG2208	phosphoserine phosphatase activity
GO004_11380	COG1191	sigma factor activity
GO004_11385	COG2172	sigma factor antagonist activity
GO004_11390	COG1366	Belongs to the anti-sigma-factor antagonist family
GO004_11395	COG2208	phosphoserine phosphatase activity
GO004_11400	COG2172	sigma factor antagonist activity
GO004_11405	COG1366	Belongs to the anti-sigma-factor antagonist family
GO004_11410	COG1366	Belongs to the anti-sigma-factor antagonist family
GO004_11415	COG2337	Toxic component of a toxin-antitoxin (TA) module
GO004_11420	COG0864	Transcriptional regulator
GO004_11425	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
GO004_11430	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
GO004_11435	COG0736	holo-[acyl-carrier-protein] synthase activity
GO004_11440	COG0705	Rhomboid family
GO004_11445	COG3428	Bacterial PH domain
GO004_11450	COG3402	PFAM membrane-flanked domain
GO004_11455	COG0513	Belongs to the DEAD box helicase family
GO004_11460	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
GO004_11465	COG1181	Belongs to the D-alanine--D-alanine ligase family
GO004_11470	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO004_11475	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
GO004_11490	COG1960	acyl-CoA dehydrogenase activity
GO004_11500	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GO004_11505	COG1131	(ABC) transporter
GO004_11510	COG0628	permease
GO004_11515	COG1301	dicarboxylic acid transport
GO004_11520	COG4565	transcriptional regulatory protein
GO004_11525	COG3290	protein histidine kinase activity
GO004_11530	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
GO004_11535	COG3546	catalase activity
GO004_11540	COG2329	Antibiotic biosynthesis monooxygenase
GO004_11545	COG0662	Cupin 2, conserved barrel domain protein
GO004_11550	COG3729	General stress protein
GO004_11555	COG2217	Heavy metal translocating P-type atpase
GO004_11560	COG4876	unkown
GO004_11565	COG2261	transglycosylase associated protein
GO004_11570	COG1914	H( )-stimulated, divalent metal cation uptake system
GO004_11595	COG0028	Belongs to the TPP enzyme family
GO004_11600	COG0494	nUDIX hydrolase
GO004_11605	COG0531	amino acid
GO004_11615	COG1215	transferase activity, transferring glycosyl groups
GO004_11625	COG3706	GGDEF domain
GO004_11630	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
GO004_11635	COG0551	DNA topoisomerase type I activity
GO004_11635	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
GO004_11640	COG1522	sequence-specific DNA binding
GO004_11645	COG2814	Major facilitator Superfamily
GO004_11655	COG3871	stress protein (general stress protein 26)
GO004_11660	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO004_11665	COG1917	Cupin 2, conserved barrel domain protein
GO004_11670	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_11675	COG2226	methyltransferase
GO004_11680	COG0318	PFAM AMP-dependent synthetase and ligase
GO004_11685	COG3711	transcriptional antiterminator
GO004_11690	COG4989	oxidoreductase activity
GO004_11695	COG0768	penicillin binding
GO004_11700	COG2329	Antibiotic biosynthesis monooxygenase
GO004_11710	COG2755	lipolytic protein G-D-S-L family
GO004_11715	COG1414	Transcriptional regulator
GO004_11720	COG1984	allophanate hydrolase subunit 2
GO004_11725	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
GO004_11730	COG4336	lyase activity
GO004_11735	COG1914	H( )-stimulated, divalent metal cation uptake system
GO004_11740	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
GO004_11745	COG0561	phosphatase activity
GO004_11755	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO004_11760	COG0412	Dienelactone hydrolase
GO004_11765	COG0681	Belongs to the peptidase S26 family
GO004_11770	COG0473	3-isopropylmalate dehydrogenase activity
GO004_11775	COG0246	Mannitol dehydrogenase
GO004_11780	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO004_11785	COG2213	PTS system mannitol-specific
GO004_11795	COG1349	DNA-binding transcription factor activity
GO004_11800	COG2372	response to copper ion
GO004_11800	COG1276	copper resistance
GO004_11805	COG4549	nuclear export factor GLE1
GO004_11810	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_11815	COG4975	Glucose uptake
GO004_11820	COG1012	belongs to the aldehyde dehydrogenase family
GO004_11825	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
GO004_11830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO004_11835	COG0640	Transcriptional regulator
GO004_11840	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
GO004_11845	COG0778	Nitroreductase
GO004_11850	COG1309	transcriptional regulator
GO004_11855	COG2814	Major facilitator Superfamily
GO004_11860	COG4607	ABC-type enterochelin transport system periplasmic component
GO004_11865	COG4604	ABC transporter, ATP-binding protein
GO004_11870	COG4605	iron ion homeostasis
GO004_11875	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO004_11880	COG0527	aspartate kinase activity
GO004_11900	COG0457	Tetratricopeptide repeat
GO004_11905	COG5002	protein histidine kinase activity
GO004_11905	COG3850	Histidine kinase
GO004_11910	COG0745	RESPONSE REGULATOR receiver
GO004_11915	COG0577	efflux transmembrane transporter activity
GO004_11920	COG1136	(ABC) transporter
GO004_11925	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GO004_11935	COG0697	spore germination
GO004_11945	COG5434	Belongs to the glycosyl hydrolase 28 family
GO004_11950	COG3104	oligopeptide transport
GO004_11955	COG0596	Alpha beta hydrolase
GO004_11970	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
GO004_11975	COG0163	prenyltransferase activity
GO004_11980	COG0583	DNA-binding transcription factor activity
GO004_11985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO004_11990	COG0765	amino acid transport
GO004_11995	COG1126	abc transporter atp-binding protein
GO004_12000	COG2364	Membrane
GO004_12010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
GO004_12015	COG0697	spore germination
GO004_12025	COG2814	Major facilitator Superfamily
GO004_12030	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
GO004_12035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_12040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_12045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_12050	COG1733	regulation of RNA biosynthetic process
GO004_12055	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
GO004_12060	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
GO004_12065	COG0840	transmembrane signaling receptor activity
GO004_12065	COG3290	protein histidine kinase activity
GO004_12070	COG3209	COG3209 Rhs family protein
GO004_12080	COG2723	6-phospho-beta-galactosidase activity
GO004_12090	COG1714	RDD family
GO004_12100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO004_12105	COG0765	amino acid transport
GO004_12120	COG1469	GTP cyclohydrolase I activity
GO004_12125	COG2223	nitrite transmembrane transporter activity
GO004_12130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GO004_12135	COG0243	molybdopterin cofactor binding
GO004_12140	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GO004_12145	COG2146	nitrite reductase [NAD(P)H] activity
GO004_12150	COG1587	Uroporphyrinogen-III synthase
GO004_12150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
GO004_12155	COG0492	ferredoxin-NADP+ reductase activity
GO004_12160	COG2267	carboxylic ester hydrolase activity
GO004_12165	COG0701	Predicted permease
GO004_12170	COG3689	TIGRFAM TIGR03943 family protein
GO004_12175	COG2508	Transcriptional regulator
GO004_12180	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO004_12185	COG1012	belongs to the aldehyde dehydrogenase family
GO004_12190	COG0506	proline dehydrogenase activity
GO004_12195	COG3541	Predicted nucleotidyltransferase
GO004_12200	COG3458	cephalosporin-C deacetylase activity
GO004_12205	COG0583	DNA-binding transcription factor activity
GO004_12210	COG2226	methyltransferase
GO004_12215	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
GO004_12220	COG1660	Displays ATPase and GTPase activities
GO004_12225	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
GO004_12230	COG3665	Urea carboxylase-associated protein
GO004_12235	COG1113	amino acid transport
GO004_12240	COG3403	YqcI/YcgG family
GO004_12245	COG1280	lysine exporter protein (LysE YggA)
GO004_12250	COG1846	Transcriptional regulator
GO004_12255	COG2814	Major facilitator Superfamily
GO004_12260	COG1620	l-lactate permease
GO004_12265	COG0039	L-malate dehydrogenase activity
GO004_12270	COG0366	Alpha amylase catalytic
GO004_12280	COG1288	antiporter activity
GO004_12285	COG1473	amidohydrolase
GO004_12290	COG2113	Glycine betaine
GO004_12295	COG4176	ABC-type proline glycine betaine transport system permease component
GO004_12300	COG0517	IMP dehydrogenase activity
GO004_12300	COG4175	Glycine betaine
GO004_12305	COG0640	Transcriptional regulator
GO004_12310	COG2814	Major facilitator Superfamily
GO004_12315	COG0477	Major facilitator Superfamily
GO004_12320	COG3853	Toxic anion resistance protein (TelA)
GO004_12330	COG0861	Integral membrane protein TerC family
GO004_12335	COG2310	stress, protein
GO004_12340	COG2310	stress, protein
GO004_12345	COG2310	stress, protein
GO004_12350	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO004_12355	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GO004_12360	COG1121	(ABC) transporter
GO004_12365	COG0803	Belongs to the bacterial solute-binding protein 9 family
GO004_12370	COG0366	Alpha amylase catalytic
GO004_12375	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_12380	COG0457	Tetratricopeptide repeat
GO004_12385	COG1876	peptidase activity
GO004_12390	COG1595	DNA-templated transcription, initiation
GO004_12395	COG1595	DNA-templated transcription, initiation
GO004_12410	COG0667	Aldo Keto reductase
GO004_12415	COG1668	transmembrane transport
GO004_12420	COG4555	ABC transporter
GO004_12425	COG3279	Response regulator of the LytR AlgR family
GO004_12430	COG3290	protein histidine kinase activity
GO004_12435	COG1405	negative regulation of cell septum assembly
GO004_12435	COG3012	SEC-C Motif Domain Protein
GO004_12440	COG1714	RDD family
GO004_12445	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
GO004_12450	COG0252	asparaginase activity
GO004_12455	COG1309	transcriptional regulator
GO004_12460	COG0477	Major facilitator Superfamily
GO004_12465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GO004_12470	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
GO004_12475	COG0805	protein transport
GO004_12480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
GO004_12485	COG3540	Alkaline phosphatase
GO004_12495	COG2304	oxidoreductase activity
GO004_12500	COG3773	Cell wall hydrolase
GO004_12520	COG1131	(ABC) transporter
GO004_12525	COG2205	protein histidine kinase activity
GO004_12530	COG0745	RESPONSE REGULATOR receiver
GO004_12535	COG0697	spore germination
GO004_12545	COG3173	Aminoglycoside phosphotransferase
GO004_12550	COG2721	sulfolactate sulfo-lyase activity
GO004_12555	COG2186	Transcriptional regulator
GO004_12560	COG4948	Mandelate Racemase Muconate Lactonizing
GO004_12565	COG2271	Major facilitator Superfamily
GO004_12570	COG1012	belongs to the aldehyde dehydrogenase family
GO004_12575	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
GO004_12580	COG0784	Response regulator, receiver
GO004_12585	COG4191	Histidine kinase
GO004_12590	COG2066	Belongs to the glutaminase family
GO004_12595	COG1115	amino acid carrier protein
GO004_12605	COG2040	homocysteine
GO004_12610	COG0833	amino acid
GO004_12615	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GO004_12625	COG2188	Transcriptional regulator
GO004_12630	COG0363	glucosamine-6-phosphate deaminase activity
GO004_12635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO004_12635	COG2190	(PTS) system
GO004_12635	COG1263	PTS System
GO004_12640	COG1301	dicarboxylic acid transport
GO004_12645	COG1054	Belongs to the UPF0176 family
GO004_12650	COG2312	Erythromycin esterase
GO004_12660	COG0688	phosphatidylethanolamine metabolic process
GO004_12665	COG0586	Pfam SNARE associated Golgi protein
GO004_12670	COG1183	phosphatidylcholine synthase activity
GO004_12675	COG0596	Alpha beta hydrolase
GO004_12685	COG3591	Belongs to the peptidase S1B family
GO004_12690	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
GO004_12695	COG1917	Cupin 2, conserved barrel domain protein
GO004_12695	COG2207	Transcriptional regulator
GO004_12700	COG0697	spore germination
GO004_12705	COG2271	Major facilitator Superfamily
GO004_12710	COG1846	Transcriptional regulator
GO004_12710	COG0456	acetyltransferase
GO004_12720	COG2271	Major facilitator Superfamily
GO004_12725	COG0584	glycerophosphoryl diester phosphodiesterase
GO004_12735	COG0531	amino acid
GO004_12745	COG2124	cytochrome p450
GO004_12750	COG2602	Beta-lactamase
GO004_12765	COG1113	amino acid transport
GO004_12780	COG0515	serine threonine protein kinase
GO004_12790	COG0642	Histidine kinase
GO004_12795	COG0745	RESPONSE REGULATOR receiver
GO004_12800	COG0596	Alpha beta hydrolase
GO004_12805	COG1132	(ABC) transporter
GO004_12825	COG1404	Belongs to the peptidase S8 family
GO004_12840	COG2814	Major facilitator Superfamily
GO004_12845	COG0640	Transcriptional regulator
GO004_12850	COG5609	conserved protein (DUF2294)
GO004_12860	COG0288	reversible hydration of carbon dioxide
GO004_12865	COG3002	Belongs to the UPF0753 family
GO004_12870	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GO004_12875	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
GO004_12880	COG2169	Transcriptional regulator
GO004_12885	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
GO004_12895	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
GO004_12900	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
GO004_12905	COG4856	YbbR-like protein
GO004_12910	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
GO004_12915	COG5662	AntiSigma factor
GO004_12920	COG1595	DNA-templated transcription, initiation
GO004_12950	COG1683	Conserved Protein
GO004_12955	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
GO004_12960	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
GO004_12965	COG1737	Transcriptional regulator
GO004_12970	COG1263	PTS System
GO004_12970	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO004_12975	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GO004_12980	COG1472	Belongs to the glycosyl hydrolase 3 family
GO004_12985	COG3876	Protein conserved in bacteria
GO004_12990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO004_12990	COG2207	Transcriptional regulator
GO004_12995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO004_13000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO004_13005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO004_13010	COG2819	hydrolase of the alpha beta superfamily
GO004_13015	COG0385	Bile acid
GO004_13020	COG0659	secondary active sulfate transmembrane transporter activity
GO004_13105	COG0726	polysaccharide deacetylase
GO004_13110	COG2194	sulfuric ester hydrolase activity
GO004_13120	COG0489	protein tyrosine kinase activity
GO004_13125	COG0860	N-Acetylmuramoyl-L-alanine amidase
GO004_13135	COG2226	methyltransferase
GO004_13140	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO004_13145	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
GO004_13150	COG0101	tRNA pseudouridine synthase activity
GO004_13155	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
GO004_13160	COG1122	ATPase activity
GO004_13165	COG1122	ATPase activity
GO004_13170	COG0203	ribosomal protein L17
GO004_13175	COG0202	RNA polymerase activity
GO004_13180	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
GO004_13185	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
GO004_13190	COG0257	Belongs to the bacterial ribosomal protein bL36 family
GO004_13200	COG2163	COG2163 Ribosomal protein L14E L6E L27E
GO004_13205	COG0024	Methionine aminopeptidase
GO004_13210	COG0563	adenylate kinase activity
GO004_13215	COG0201	protein transport
GO004_13220	COG0200	Binds to the 23S rRNA
GO004_13230	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
GO004_13235	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
GO004_13240	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
GO004_13245	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
GO004_13255	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
GO004_13265	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
GO004_13270	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
GO004_13280	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
GO004_13300	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
GO004_13310	COG0088	Forms part of the polypeptide exit tunnel
GO004_13315	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
GO004_13325	COG0596	Alpha beta hydrolase
GO004_13330	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
GO004_13335	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
GO004_13340	COG0049	tRNA binding
GO004_13345	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
GO004_13350	COG1358	cellular component organization or biogenesis
GO004_13355	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
GO004_13360	COG0085	RNA polymerase activity
GO004_13365	COG2813	Specifically methylates the guanine in position
GO004_13375	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
GO004_13380	COG0081	regulation of translation
GO004_13390	COG0250	Participates in transcription elongation, termination and antitermination
GO004_13395	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GO004_13405	COG1595	DNA-templated transcription, initiation
GO004_13410	COG3688	RNA-binding protein containing a PIN domain
GO004_13415	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GO004_13420	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
GO004_13425	COG0215	cysteine-tRNA ligase activity
GO004_13430	COG1045	serine acetyltransferase
GO004_13435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
GO004_13440	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
GO004_13445	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
GO004_13450	COG4956	integral membrane protein (PIN domain superfamily)
GO004_13455	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
GO004_13460	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
GO004_13465	COG0542	response to heat
GO004_13470	COG3869	Catalyzes the specific phosphorylation of arginine residues in
GO004_13475	COG3880	PFAM UvrB UvrC protein
GO004_13480	COG4463	regulation of RNA biosynthetic process
GO004_13560	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
GO004_13565	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
GO004_13570	COG1396	sequence-specific DNA binding
GO004_13575	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
GO004_13580	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
GO004_13585	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
GO004_13590	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GO004_13595	COG0512	Glutamine amidotransferase of anthranilate synthase
GO004_13600	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
GO004_13605	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GO004_13610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
GO004_13615	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
GO004_13620	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
GO004_13625	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
GO004_13630	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
GO004_13635	COG0037	tRNA processing
GO004_13640	COG0515	serine threonine protein kinase
GO004_13645	COG2304	oxidoreductase activity
GO004_13650	COG2208	phosphoserine phosphatase activity
GO004_13665	COG1098	S1 RNA binding domain
GO004_13670	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
GO004_13685	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
GO004_13690	COG3956	TIGRFAM MazG family protein
GO004_13695	COG2244	polysaccharide biosynthetic process
GO004_13700	COG2002	toxin-antitoxin pair type II binding
GO004_13705	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
GO004_13715	COG0193	aminoacyl-tRNA hydrolase activity
GO004_13720	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
GO004_13725	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
GO004_13730	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
GO004_13735	COG2088	sporulation resulting in formation of a cellular spore
GO004_13740	COG0251	oxidation-reduction process
GO004_13745	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GO004_13750	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
GO004_13760	COG4466	Protein conserved in bacteria
GO004_13770	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
GO004_13775	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GO004_13780	COG3583	domain protein
GO004_13780	COG3584	3D domain protein
GO004_13785	COG0084	hydrolase, TatD family'
GO004_13790	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO004_13790	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO004_13795	COG2002	toxin-antitoxin pair type II binding
GO004_13800	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
GO004_13805	COG2827	Endonuclease containing a URI domain
GO004_13810	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
GO004_13815	COG4467	Involved in initiation control of chromosome replication
GO004_13820	COG1774	PSP1 C-terminal conserved region
GO004_13825	COG0470	DNA polymerase III
GO004_13830	COG1728	Protein conserved in bacteria
GO004_13835	COG3870	Protein conserved in bacteria
GO004_13840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
GO004_13845	COG1982	Orn Lys Arg decarboxylase major
GO004_13850	COG3853	Toxic anion resistance protein (TelA)
GO004_13855	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
GO004_13900	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
GO004_13905	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
GO004_13910	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
GO004_13920	COG0590	tRNA wobble adenosine to inosine editing
GO004_13925	COG1335	isochorismatase
GO004_13930	COG1388	LysM domain
GO004_13930	COG3858	chitin binding
GO004_13935	COG1428	Deoxynucleoside kinase
GO004_13940	COG1428	Deoxynucleoside kinase
GO004_13950	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
GO004_13955	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
GO004_13960	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
GO004_13965	COG1686	Belongs to the peptidase S11 family
GO004_13970	COG0517	IMP dehydrogenase activity
GO004_13970	COG0516	GMP reductase activity
GO004_14005	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
GO004_14010	COG0187	DNA topoisomerase II activity
GO004_14020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
GO004_14025	COG2501	S4 domain
GO004_14030	COG0592	DNA-directed DNA polymerase activity
GO004_14035	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
GO004_14045	COG0594	ribonuclease P activity
GO004_14050	COG0706	membrane insertase activity
GO004_14055	COG1847	R3H domain protein
GO004_14060	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
GO004_14065	COG0445	tRNA wobble uridine modification
GO004_14070	COG0357	Ribosomal RNA small subunit methyltransferase G
GO004_14075	COG1475	DNA binding
GO004_14085	COG1192	Involved in chromosome partitioning
GO004_14090	COG1475	DNA binding
GO004_14100	COG3949	Membrane
GO004_14105	COG4481	Protein conserved in bacteria
GO004_14110	COG0243	molybdopterin cofactor binding
GO004_14115	COG0012	GTP binding
GO004_14120	COG0360	Binds together with S18 to 16S ribosomal RNA
GO004_14125	COG0629	single-stranded DNA binding
GO004_14130	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
GO004_14135	COG0708	Exodeoxyribonuclease III
GO004_14140	COG1609	Transcriptional regulator
GO004_14145	COG0346	lactoylglutathione lyase activity
GO004_14150	COG0110	maltose O-acetyltransferase activity
GO004_14155	COG0477	Major facilitator Superfamily
GO004_14155	COG2814	Major facilitator Superfamily
GO004_14160	COG1266	CAAX protease self-immunity
GO004_14165	COG1331	Highly conserved protein containing a thioredoxin domain
GO004_14175	COG2814	Major facilitator Superfamily
GO004_14185	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GO004_14190	COG2315	Protein conserved in bacteria
GO004_14195	COG0456	acetyltransferase
GO004_14200	COG2364	Membrane
GO004_14205	COG2153	protein acetylation
GO004_14210	COG1846	Transcriptional regulator
GO004_14215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO004_14225	COG2153	protein acetylation
GO004_14230	COG0583	DNA-binding transcription factor activity
GO004_14235	COG2814	Major facilitator Superfamily
GO004_14240	COG1357	PFAM Pentapeptide repeats (8 copies)
GO004_14245	COG4319	ketosteroid isomerase
GO004_14255	COG0789	Transcriptional regulator
GO004_14255	COG4978	Transcriptional regulator
GO004_14260	COG2271	Major facilitator Superfamily
GO004_14275	COG1227	inorganic diphosphatase activity
GO004_14280	COG1733	regulation of RNA biosynthetic process
GO004_14285	COG5577	PFAM Coat F domain
GO004_14295	COG4241	membrane
GO004_14300	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
GO004_14305	COG0359	binds to the 23S rRNA
GO004_14310	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
GO004_14315	COG2807	transmembrane transport
GO004_14320	COG3093	addiction module antidote protein HigA
GO004_14335	COG0305	Participates in initiation and elongation during chromosome replication
GO004_14340	COG0346	lactoylglutathione lyase activity
GO004_14370	COG0745	RESPONSE REGULATOR receiver
GO004_14375	COG5002	protein histidine kinase activity
GO004_14380	COG4863	YycH protein
GO004_14385	COG4853	Protein conserved in bacteria
GO004_14390	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
GO004_14395	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GO004_14410	COG3829	transcription factor binding
GO004_14415	COG0640	Transcriptional regulator
GO004_14420	COG5658	integral membrane protein
GO004_14440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
GO004_14445	COG0833	amino acid
GO004_14450	COG0010	Belongs to the arginase family
GO004_14460	COG0457	Tetratricopeptide repeat
GO004_14465	COG0456	acetyltransferase
GO004_14470	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
GO004_14490	COG1063	alcohol dehydrogenase
GO004_14505	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
GO004_14520	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
GO004_14535	COG3634	alkyl hydroperoxide reductase activity
GO004_14540	COG0450	alkyl hydroperoxide reductase
GO004_14545	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
GO004_14550	COG2610	gluconate transmembrane transporter activity
GO004_14555	COG1070	Carbohydrate kinase
GO004_14560	COG1802	Transcriptional regulator
GO004_14565	COG1929	Belongs to the glycerate kinase type-1 family
GO004_14570	COG5039	Polysaccharide pyruvyl transferase
GO004_14575	COG1346	cytolysis
GO004_14580	COG1380	Effector of murein hydrolase LrgA
GO004_14585	COG1846	Transcriptional regulator
GO004_14590	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_14595	COG1309	transcriptional regulator
GO004_14600	COG1917	Cupin 2, conserved barrel domain protein
GO004_14605	COG2311	Membrane
GO004_14610	COG1714	RDD family
GO004_14620	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
GO004_14625	COG2814	Major facilitator Superfamily
GO004_14630	COG0367	asparagine synthase
GO004_14645	COG2226	methyltransferase
GO004_14650	COG2850	peptidyl-arginine hydroxylation
GO004_14655	COG0456	acetyltransferase
GO004_14660	COG1012	belongs to the aldehyde dehydrogenase family
GO004_14665	COG1309	transcriptional regulator
GO004_14670	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_14680	COG0326	Molecular chaperone. Has ATPase activity
GO004_14685	COG2814	Major facilitator Superfamily
GO004_14700	COG0667	Aldo Keto reductase
GO004_14705	COG1349	DNA-binding transcription factor activity
GO004_14710	COG1012	belongs to the aldehyde dehydrogenase family
GO004_14720	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO004_14725	COG3962	Belongs to the TPP enzyme family
GO004_14730	COG1082	Xylose isomerase domain protein TIM barrel
GO004_14735	COG2814	Major facilitator Superfamily
GO004_14740	COG0673	inositol 2-dehydrogenase activity
GO004_14745	COG1082	Xylose isomerase domain protein TIM barrel
GO004_14750	COG1082	Xylose isomerase domain protein TIM barrel
GO004_14755	COG0191	fructose-bisphosphate aldolase activity
GO004_14760	COG0745	RESPONSE REGULATOR receiver
GO004_14765	COG2205	protein histidine kinase activity
GO004_14770	COG1136	(ABC) transporter
GO004_14775	COG0577	efflux transmembrane transporter activity
GO004_14780	COG5294	Protein conserved in bacteria
GO004_14785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO004_14815	COG0561	phosphatase activity
GO004_14820	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
GO004_14825	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO004_14830	COG0456	acetyltransferase
GO004_14835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO004_14840	COG0765	amino acid transport
GO004_14845	COG1126	abc transporter atp-binding protein
GO004_14850	COG1473	amidohydrolase
GO004_14855	COG2079	MmgE PrpD family protein
GO004_14860	COG3192	ethanolamine utilization protein
GO004_14870	COG2390	Transcriptional regulator
GO004_14875	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
GO004_14880	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GO004_14885	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
GO004_14890	COG0833	amino acid
GO004_14895	COG0010	Belongs to the arginase family
GO004_14900	COG1228	amidohydrolase
GO004_14905	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
GO004_14910	COG2986	histidine ammonia-lyase
GO004_14920	COG3507	Belongs to the glycosyl hydrolase 43 family
GO004_14935	COG5444	nuclease activity
GO004_14950	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO004_14950	COG1263	PTS System
GO004_14950	COG2190	(PTS) system
GO004_14955	COG2723	6-phospho-beta-galactosidase activity
GO004_14960	COG0589	response to stress
GO004_14965	COG0697	spore germination
GO004_14970	COG3209	COG3209 Rhs family protein
GO004_15030	COG2755	lipolytic protein G-D-S-L family
GO004_15030	COG3401	FG-GAP repeat protein
GO004_15035	COG0513	Belongs to the DEAD box helicase family
GO004_15040	COG2270	Major facilitator Superfamily
GO004_15050	COG3711	transcriptional antiterminator
GO004_15055	COG2273	Hydrolase Family 16
GO004_15060	COG2851	Citrate transporter
GO004_15065	COG0753	catalase activity
GO004_15065	COG0693	protein deglycase activity
GO004_15080	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GO004_15085	COG0500	methyltransferase
GO004_15090	COG2610	gluconate transmembrane transporter activity
GO004_15095	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
GO004_15100	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
GO004_15105	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_15110	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GO004_15115	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
GO004_15120	COG4894	glucomannan catabolic process
GO004_15130	COG2195	Cleaves the N-terminal amino acid of tripeptides
GO004_15135	COG2197	response regulator
GO004_15140	COG4585	Histidine kinase
GO004_15150	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
GO004_15160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GO004_15165	COG1012	belongs to the aldehyde dehydrogenase family
GO004_15170	COG2508	Transcriptional regulator
GO004_15175	COG3842	ATPase activity
GO004_15180	COG0726	polysaccharide deacetylase
GO004_15190	COG0501	Belongs to the peptidase M48B family
GO004_15195	COG3493	citrate carrier protein
GO004_15200	COG1271	oxidase subunit
GO004_15205	COG1294	oxidase, subunit
GO004_15210	COG4988	ABC transporter
GO004_15215	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
GO004_15220	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
GO004_15225	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
GO004_15230	COG1595	DNA-templated transcription, initiation
GO004_15250	COG1131	(ABC) transporter
GO004_15255	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
GO004_15265	COG0753	catalase activity
GO004_15270	COG2094	Belongs to the DNA glycosylase MPG family
GO004_15280	COG3711	transcriptional antiterminator
GO004_15280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO004_15285	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GO004_15290	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GO004_15295	COG1447	Phosphotransferase system cellobiose-specific component IIA
GO004_15300	COG1486	melibiose metabolic process
GO004_15305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
GO004_15310	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
GO004_15315	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
GO004_15320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
GO004_15325	COG1696	Membrane protein involved in D-alanine export
GO004_15330	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_15345	COG1575	Belongs to the MenA family. Type 1 subfamily
GO004_15350	COG2357	RelA SpoT domain protein
GO004_15355	COG2814	Major facilitator Superfamily
GO004_15370	COG2234	aminopeptidase activity
GO004_15375	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GO004_15380	COG1846	Transcriptional regulator
GO004_15385	COG5522	Integral membrane protein (intg_mem_TP0381)
GO004_15390	COG1442	glycosyl transferase family 8
GO004_15395	COG3711	transcriptional antiterminator
GO004_15400	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO004_15400	COG1263	PTS System
GO004_15405	COG1404	Belongs to the peptidase S8 family
GO004_15410	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
GO004_15425	COG0346	lactoylglutathione lyase activity
GO004_15430	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
GO004_15435	COG4895	conserved protein (DUF2196)
GO004_15440	COG2814	Major facilitator Superfamily
GO004_15445	COG1346	cytolysis
GO004_15450	COG1380	Effector of murein hydrolase LrgA
GO004_15455	COG0583	DNA-binding transcription factor activity
GO004_15460	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
GO004_15465	COG0352	thiamine-phosphate diphosphorylase activity
GO004_15470	COG0672	)-iron permease
GO004_15475	COG2822	iron ion transport
GO004_15480	COG2837	iron assimilation
GO004_15485	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
GO004_15490	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
GO004_15495	COG3162	membrane
GO004_15505	COG1309	transcriptional regulator
GO004_15510	COG2246	polysaccharide biosynthetic process
GO004_15515	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
GO004_15520	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
GO004_15525	COG2261	transglycosylase associated protein
GO004_15530	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
GO004_15535	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
GO004_15540	COG1845	cytochrome c oxidase, subunit III
GO004_15545	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
GO004_15555	COG0772	Belongs to the SEDS family
GO004_15560	COG0778	Nitroreductase
GO004_15565	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO004_15570	COG1404	Belongs to the peptidase S8 family
GO004_15580	COG3711	transcriptional antiterminator
GO004_15585	COG2116	formate transmembrane transporter activity
GO004_15590	COG1263	PTS System
GO004_15590	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO004_15595	COG1621	beta-fructofuranosidase activity
GO004_15605	COG0351	phosphomethylpyrimidine kinase
GO004_15610	COG1216	Glycosyl transferase, family 2
GO004_15615	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
GO004_15620	COG1012	belongs to the aldehyde dehydrogenase family
GO004_15630	COG2233	PERMEase
GO004_15635	COG2363	Small membrane protein
GO004_15645	COG0463	Glycosyl transferase, family 2
GO004_15650	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GO004_15655	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GO004_15660	COG0456	acetyltransferase
GO004_15665	COG2089	acid synthase
GO004_15670	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
GO004_15675	COG3980	spore coat polysaccharide biosynthesis protein
GO004_15680	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
GO004_15685	COG1088	dTDP-glucose 4,6-dehydratase activity
GO004_15690	COG1091	dTDP-4-dehydrorhamnose reductase activity
GO004_15695	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
GO004_15705	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
GO004_15710	COG1012	belongs to the aldehyde dehydrogenase family
GO004_15715	COG4187	Peptidase family M20/M25/M40
GO004_15720	COG0833	amino acid
GO004_15725	COG2814	Major facilitator Superfamily
GO004_15730	COG0077	Prephenate dehydratase
GO004_15735	COG1917	Cupin 2, conserved barrel domain protein
GO004_15740	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_15745	COG0151	Belongs to the GarS family
GO004_15750	COG2814	Major facilitator Superfamily
GO004_15755	COG0436	Aminotransferase
GO004_15760	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_15765	COG3253	May function as heme-dependent peroxidase
GO004_15770	COG0280	phosphate acetyltransferase
GO004_15775	COG0583	DNA-binding transcription factor activity
GO004_15780	COG0095	Lipoate-protein ligase
GO004_15785	COG0697	spore germination
GO004_15795	COG4844	belongs to the
GO004_15800	COG1078	dGTPase activity
GO004_15805	COG3465	dGTPase activity
GO004_15810	COG1959	2 iron, 2 sulfur cluster binding
GO004_15815	COG0477	Major facilitator Superfamily
GO004_15825	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GO004_15830	COG1846	Transcriptional regulator
GO004_15835	COG1942	4-Oxalocrotonate Tautomerase
GO004_15840	COG1994	Peptidase M50
GO004_15850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GO004_15855	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
GO004_15860	COG0010	Belongs to the arginase family
GO004_15870	COG1131	(ABC) transporter
GO004_15900	COG0457	Tetratricopeptide repeat
GO004_15910	COG3391	amine dehydrogenase activity
GO004_15915	COG3391	amine dehydrogenase activity
GO004_15925	COG0612	Peptidase, M16
GO004_15930	COG0612	Peptidase, M16
GO004_15935	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
GO004_15940	COG1131	(ABC) transporter
GO004_15950	COG0535	radical SAM domain protein
GO004_15965	COG4506	Protein conserved in bacteria
GO004_15970	COG0018	arginyl-trna synthetase
GO004_15975	COG2223	nitrite transmembrane transporter activity
GO004_15980	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GO004_15990	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
GO004_15995	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
GO004_16000	COG1140	nitrate reductase beta subunit
GO004_16005	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
GO004_16010	COG2181	nitrate reductase activity
GO004_16020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GO004_16025	COG1132	(ABC) transporter
GO004_16030	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
GO004_16040	COG4294	response to UV
GO004_16045	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GO004_16050	COG0247	lactate metabolic process
GO004_16050	COG2181	nitrate reductase activity
GO004_16055	COG1960	acyl-CoA dehydrogenase activity
GO004_16060	COG3343	RNA polymerase activity
GO004_16065	COG0504	CTP synthase activity
GO004_16070	COG4821	SIS domain
GO004_16075	COG2204	response regulator
GO004_16080	COG0191	fructose-bisphosphate aldolase activity
GO004_16085	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
GO004_16090	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GO004_16095	COG1494	fructose-1,6-bisphosphatase
GO004_16105	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
GO004_16115	COG1435	thymidine kinase activity
GO004_16120	COG0281	malic enzyme
GO004_16125	COG0679	Auxin Efflux Carrier
GO004_16130	COG0789	Transcriptional regulator
GO004_16135	COG0346	lactoylglutathione lyase activity
GO004_16140	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
GO004_16145	COG2890	protein-(glutamine-N5) methyltransferase activity
GO004_16165	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
GO004_16170	COG0009	L-threonylcarbamoyladenylate synthase
GO004_16175	COG1971	Probably functions as a manganese efflux pump
GO004_16180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
GO004_16185	COG0698	ribose 5-phosphate isomerase
GO004_16190	COG4475	Protein of unknown function (DUF436)
GO004_16195	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
GO004_16200	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
GO004_16210	COG0356	it plays a direct role in the translocation of protons across the membrane
GO004_16220	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
GO004_16225	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
GO004_16230	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
GO004_16235	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
GO004_16240	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
GO004_16245	COG0355	proton-transporting ATP synthase activity, rotational mechanism
GO004_16255	COG4836	Membrane
GO004_16265	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
GO004_16270	COG2385	sporulation resulting in formation of a cellular spore
GO004_16275	COG2304	oxidoreductase activity
GO004_16285	COG2304	oxidoreductase activity
GO004_16295	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
GO004_16300	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
GO004_16305	COG0457	Tetratricopeptide repeat
GO004_16310	COG1994	Peptidase M50
GO004_16315	COG3237	CsbD-like
GO004_16330	COG0831	urea catabolic process
GO004_16335	COG0832	Belongs to the urease beta subunit family
GO004_16340	COG0804	urea catabolic process
GO004_16345	COG1959	2 iron, 2 sulfur cluster binding
GO004_16350	COG2910	NAD(P)H-binding
GO004_16360	COG0789	Transcriptional regulator
GO004_16365	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
GO004_16385	COG1247	-acetyltransferase
GO004_16390	COG0739	heme binding
GO004_16400	COG0671	phosphoesterase, PA-phosphatase related
GO004_16405	COG0347	Belongs to the P(II) protein family
GO004_16410	COG0004	ammonium transporteR
GO004_16420	COG1335	isochorismatase
GO004_16425	COG0477	Major facilitator Superfamily
GO004_16430	COG1953	Uracil, thiamine, allantoin
GO004_16435	COG3420	alginic acid biosynthetic process
GO004_16440	COG2814	Major facilitator Superfamily
GO004_16445	COG1846	Transcriptional regulator
GO004_16455	COG1609	Transcriptional regulator
GO004_16460	COG1077	Cell shape determining protein MreB Mrl
GO004_16465	COG4786	Flagellar basal body rod
GO004_16470	COG4786	Flagellar basal body rod
GO004_16475	COG0457	Tetratricopeptide repeat
GO004_16480	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
GO004_16485	COG1970	mechanosensitive ion channel activity
GO004_16490	COG0745	RESPONSE REGULATOR receiver
GO004_16490	COG2972	Histidine kinase
GO004_16495	COG3764	Sortase (surface protein transpeptidase)
GO004_16510	COG0629	single-stranded DNA binding
GO004_16515	COG1349	DNA-binding transcription factor activity
GO004_16520	COG0561	phosphatase activity
GO004_16525	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
GO004_16530	COG4715	Zinc finger, swim domain protein
GO004_16540	COG3944	biosynthesis protein
GO004_16545	COG0489	protein tyrosine kinase activity
GO004_16550	COG4464	protein tyrosine phosphatase activity
GO004_16555	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GO004_16560	COG3878	Protein conserved in bacteria
GO004_16580	COG5444	nuclease activity
GO004_16595	COG0583	DNA-binding transcription factor activity
GO004_16600	COG0655	NAD(P)H dehydrogenase (quinone) activity
GO004_16610	COG2059	Chromate
GO004_16615	COG2059	Chromate
GO004_16620	COG1522	sequence-specific DNA binding
GO004_16625	COG0405	Gamma-glutamyltransferase
GO004_16630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
GO004_16640	COG5337	Spore coat protein CotH
GO004_16655	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
GO004_16660	COG0583	DNA-binding transcription factor activity
GO004_16665	COG0028	Belongs to the TPP enzyme family
GO004_16670	COG3527	Alpha-acetolactate decarboxylase
GO004_16675	COG2249	NAD(P)H dehydrogenase (quinone) activity
GO004_16685	COG3103	Sh3 type 3 domain protein
GO004_16690	COG1879	ABC-type sugar transport system periplasmic component
GO004_16695	COG1172	Belongs to the binding-protein-dependent transport system permease family
GO004_16700	COG1129	ABC transporter
GO004_16705	COG1869	D-ribose catabolic process
GO004_16710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO004_16715	COG1609	Transcriptional regulator
GO004_16720	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
GO004_16730	COG2843	Capsule synthesis protein
GO004_16740	COG0791	NLP P60 protein
GO004_16745	COG0561	phosphatase activity
GO004_16750	COG1316	TRANSCRIPTIONal
GO004_16755	COG2814	Major facilitator Superfamily
GO004_16765	COG0814	amino acid
GO004_16770	COG0697	spore germination
GO004_16775	COG1482	cell wall glycoprotein biosynthetic process
GO004_16780	COG4193	domain, Protein
GO004_16790	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GO004_16795	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
GO004_16800	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
GO004_16805	COG0438	transferase activity, transferring glycosyl groups
GO004_16810	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
GO004_16815	COG1682	transport, permease protein
GO004_16820	COG1134	teichoic acid transport
GO004_16825	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GO004_16830	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
GO004_16835	COG1316	TRANSCRIPTIONal
GO004_16845	COG2247	cell wall binding repeat
GO004_16845	COG2385	sporulation resulting in formation of a cellular spore
GO004_16850	COG0860	N-Acetylmuramoyl-L-alanine amidase
GO004_16850	COG2247	cell wall binding repeat
GO004_16860	COG2244	polysaccharide biosynthetic process
GO004_16865	COG0297	glycogen (starch) synthase activity
GO004_16865	COG0438	transferase activity, transferring glycosyl groups
GO004_16870	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GO004_16875	COG3307	-O-antigen
GO004_16880	COG3206	protein involved in exopolysaccharide biosynthesis
GO004_16885	COG1215	transferase activity, transferring glycosyl groups
GO004_16890	COG0438	transferase activity, transferring glycosyl groups
GO004_16895	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
GO004_16900	COG1316	TRANSCRIPTIONal
GO004_16905	COG1739	Uncharacterized protein family UPF0029
GO004_16910	COG4585	Histidine kinase
GO004_16915	COG2197	response regulator
GO004_16920	COG1307	EDD domain protein, DegV family
GO004_16925	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
GO004_16935	COG1040	competence protein
GO004_16945	COG2747	anti-sigma28 factor FlgM
GO004_16950	COG3418	PFAM FlgN family protein
GO004_16955	COG4786	Flagellar basal body rod
GO004_16955	COG1256	bacterial-type flagellum assembly
GO004_16960	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GO004_16970	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
GO004_16975	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
GO004_16980	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
GO004_16985	COG1334	flagellar protein FlaG
GO004_16990	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
GO004_16995	COG1516	flagellar protein fliS
GO004_17010	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
GO004_17015	COG0653	protein targeting
GO004_17025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
GO004_17030	COG2010	Cytochrome c
GO004_17035	COG2884	Cell division ATP-binding protein ftsE
GO004_17040	COG2177	Part of the ABC transporter FtsEX involved in
GO004_17045	COG0793	Belongs to the peptidase S41A family
GO004_17045	COG3409	Peptidoglycan-binding domain 1 protein
GO004_17055	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GO004_17060	COG2814	Major facilitator Superfamily
GO004_17065	COG1309	transcriptional regulator
GO004_17070	COG0574	Belongs to the PEP-utilizing enzyme family
GO004_17070	COG3848	Pyruvate phosphate dikinase
GO004_17075	COG4897	Protein conserved in bacteria
GO004_17080	COG0556	nucleotide-excision repair
GO004_17085	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
GO004_17105	COG3595	metallopeptidase activity
GO004_17110	COG1983	PspC domain protein
GO004_17115	COG1950	PFAM Membrane protein of
GO004_17120	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
GO004_17125	COG2188	Transcriptional regulator
GO004_17130	COG0363	glucosamine-6-phosphate deaminase activity
GO004_17135	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
GO004_17140	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
GO004_17145	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
GO004_17150	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
GO004_17155	COG0546	phosphoglycolate phosphatase activity
GO004_17160	COG0110	maltose O-acetyltransferase activity
GO004_17165	COG5297	Belongs to the glycosyl hydrolase family 6
GO004_17170	COG4990	cell redox homeostasis
GO004_17175	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
GO004_17180	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
GO004_17185	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
GO004_17190	COG0131	Imidazoleglycerol-phosphate dehydratase
GO004_17195	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
GO004_17200	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
GO004_17205	COG0107	imidazoleglycerol-phosphate synthase activity
GO004_17210	COG0140	phosphoribosyl-ATP diphosphatase activity
GO004_17210	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
GO004_17230	COG1132	(ABC) transporter
GO004_17235	COG0457	Tetratricopeptide repeat
GO004_17240	COG0791	NLP P60 protein
GO004_17240	COG3883	PFAM NLP P60 protein
GO004_17245	COG0492	ferredoxin-NADP+ reductase activity
GO004_17250	COG1051	belongs to the nudix hydrolase family
GO004_17255	COG1660	Displays ATPase and GTPase activities
GO004_17260	COG0391	Required for morphogenesis under gluconeogenic growth conditions
GO004_17265	COG1481	regulation of sporulation
GO004_17270	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO004_17275	COG2162	N-hydroxyarylamine O-acetyltransferase activity
GO004_17285	COG0745	RESPONSE REGULATOR receiver
GO004_17290	COG5002	protein histidine kinase activity
GO004_17295	COG1136	(ABC) transporter
GO004_17300	COG0577	efflux transmembrane transporter activity
GO004_17305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
GO004_17310	COG0288	reversible hydration of carbon dioxide
GO004_17315	COG0659	secondary active sulfate transmembrane transporter activity
GO004_17320	COG1694	Mazg nucleotide pyrophosphohydrolase
GO004_17325	COG1611	Belongs to the LOG family
GO004_17330	COG1609	Transcriptional regulator
GO004_17335	COG0366	Alpha amylase catalytic
GO004_17340	COG2182	Extracellular solute-binding protein
GO004_17345	COG1175	transmembrane transport
GO004_17350	COG3833	ABC-type maltose transport systems, permease component
GO004_17355	COG5521	maltodextrose utilization protein MalA
GO004_17360	COG1554	hydrolase, family 65, central catalytic
GO004_17365	COG0366	Alpha amylase catalytic
GO004_17370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
GO004_17375	COG0740	serine-type endopeptidase activity
GO004_17385	COG3621	Patatin-like phospholipase
GO004_17390	COG0277	FAD linked oxidase domain protein
GO004_17400	COG2076	Multidrug Resistance protein
GO004_17405	COG2076	Multidrug Resistance protein
GO004_17410	COG1309	transcriptional regulator
GO004_17415	COG0531	amino acid
GO004_17420	COG1621	beta-fructofuranosidase activity
GO004_17425	COG1621	beta-fructofuranosidase activity
GO004_17430	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
GO004_17435	COG1794	racemase activity, acting on amino acids and derivatives
GO004_17445	COG3479	Phenolic acid decarboxylase
GO004_17455	COG2272	Belongs to the type-B carboxylesterase lipase family
GO004_17460	COG1396	sequence-specific DNA binding
GO004_17465	COG3944	biosynthesis protein
GO004_17470	COG0489	protein tyrosine kinase activity
GO004_17475	COG1086	Polysaccharide biosynthesis protein
GO004_17480	COG0438	transferase activity, transferring glycosyl groups
GO004_17485	COG1215	transferase activity, transferring glycosyl groups
GO004_17490	COG0438	transferase activity, transferring glycosyl groups
GO004_17500	COG1216	Glycosyl transferase, family 2
GO004_17505	COG5039	Polysaccharide pyruvyl transferase
GO004_17510	COG1216	Glycosyl transferase, family 2
GO004_17515	COG2244	polysaccharide biosynthetic process
GO004_17520	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
GO004_17525	COG0110	maltose O-acetyltransferase activity
GO004_17530	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
GO004_17535	COG5039	Polysaccharide pyruvyl transferase
GO004_17545	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
GO004_17550	COG1620	l-lactate permease
GO004_17555	COG2186	Transcriptional regulator
GO004_17560	COG1609	Transcriptional regulator
GO004_17565	COG2182	Extracellular solute-binding protein
GO004_17570	COG1175	transmembrane transport
GO004_17575	COG3833	ABC-type maltose transport systems, permease component
GO004_17580	COG1874	Beta-galactosidase
GO004_17585	COG3867	Arabinogalactan endo-beta-1,4-galactanase
GO004_17590	COG2208	phosphoserine phosphatase activity
GO004_17595	COG0596	Alpha beta hydrolase
GO004_17600	COG1131	(ABC) transporter
GO004_17605	COG0842	Transport permease protein
GO004_17610	COG4585	Histidine kinase
GO004_17615	COG2197	response regulator
GO004_17620	COG0247	lactate metabolic process
GO004_17625	COG1139	Iron-sulfur cluster binding protein
GO004_17630	COG1556	Lactate utilization protein
GO004_17635	COG3858	chitin binding
GO004_17640	COG1113	amino acid transport
GO004_17645	COG0697	spore germination
GO004_17650	COG0583	DNA-binding transcription factor activity
GO004_17655	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO004_17660	COG1609	Transcriptional regulator
GO004_17665	COG2814	Major facilitator Superfamily
GO004_17670	COG2390	Transcriptional regulator
GO004_17675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO004_17680	COG0126	phosphoglycerate kinase activity
GO004_17685	COG0149	triose-phosphate isomerase activity
GO004_17690	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
GO004_17695	COG0148	phosphopyruvate hydratase activity
GO004_17700	COG0456	acetyltransferase
GO004_17705	COG4640	response to antibiotic
GO004_17710	COG3064	Membrane
GO004_17720	COG2095	MarC family integral membrane protein
GO004_17725	COG1510	regulation of RNA biosynthetic process
GO004_17730	COG0517	IMP dehydrogenase activity
GO004_17730	COG1125	glycine betaine transport
GO004_17735	COG1174	glycine betaine transport
GO004_17740	COG1732	Glycine betaine
GO004_17745	COG1174	glycine betaine transport
GO004_17750	COG1510	regulation of RNA biosynthetic process
GO004_17755	COG1125	glycine betaine transport
GO004_17755	COG0517	IMP dehydrogenase activity
GO004_17760	COG1174	glycine betaine transport
GO004_17765	COG1732	Glycine betaine
GO004_17770	COG1174	glycine betaine transport
GO004_17775	COG0840	transmembrane signaling receptor activity
GO004_17780	COG1733	regulation of RNA biosynthetic process
GO004_17785	COG1396	sequence-specific DNA binding
GO004_17790	COG1396	sequence-specific DNA binding
GO004_17795	COG1476	TRANSCRIPTIONal
GO004_17800	COG0596	Alpha beta hydrolase
GO004_17805	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
GO004_17810	COG1647	Serine aminopeptidase, S33
GO004_17815	COG0557	exoribonuclease II activity
GO004_17820	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
GO004_17830	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_17835	COG1309	transcriptional regulator
GO004_17840	COG2076	Multidrug Resistance protein
GO004_17850	COG1289	transmembrane transporter activity
GO004_17855	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
GO004_17860	COG0673	inositol 2-dehydrogenase activity
GO004_17865	COG1937	Protein conserved in bacteria
GO004_17870	COG2608	mercury ion transmembrane transporter activity
GO004_17875	COG2217	Heavy metal translocating P-type atpase
GO004_17880	COG2217	Heavy metal translocating P-type atpase
GO004_17885	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
GO004_17890	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
GO004_17895	COG2860	membrane
GO004_17905	COG3973	AAA domain
GO004_17910	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GO004_17915	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
GO004_17920	COG0025	NhaP-type Na H and K H
GO004_17930	COG0656	L-ascorbic acid biosynthetic process
GO004_17935	COG4149	molybdate abc transporter
GO004_17940	COG0725	ABC transporter, periplasmic molybdate-binding protein
GO004_17945	COG1910	domain protein
GO004_17950	COG1368	sulfuric ester hydrolase activity
GO004_17955	COG1988	membrane-bound metal-dependent
GO004_17965	COG0531	amino acid
GO004_17970	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO004_17975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO004_17980	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO004_17985	COG1120	ATPase activity
GO004_17990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
GO004_17995	COG1136	(ABC) transporter
GO004_18000	COG0577	efflux transmembrane transporter activity
GO004_18010	COG2140	Oxalate decarboxylase
GO004_18020	COG1191	sigma factor activity
GO004_18030	COG0745	RESPONSE REGULATOR receiver
GO004_18035	COG2205	protein histidine kinase activity
GO004_18040	COG3386	PFAM SMP-30 Gluconolaconase
GO004_18045	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_18050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
GO004_18055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
GO004_18060	COG1120	ATPase activity
GO004_18065	COG2096	Adenosyltransferase
GO004_18070	COG2814	Major facilitator Superfamily
GO004_18075	COG4758	membrane
GO004_18080	COG1842	Phage shock protein A
GO004_18085	COG3595	metallopeptidase activity
GO004_18090	COG4758	membrane
GO004_18095	COG4585	Histidine kinase
GO004_18100	COG2197	response regulator
GO004_18110	COG0814	amino acid
GO004_18115	COG0697	spore germination
GO004_18125	COG0114	fumarate hydratase activity
GO004_18130	COG1309	transcriptional regulator
GO004_18140	COG2205	protein histidine kinase activity
GO004_18140	COG2770	Histidine kinase
GO004_18145	COG0745	RESPONSE REGULATOR receiver
GO004_18150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
GO004_18155	COG0783	Belongs to the Dps family
GO004_18160	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_18175	COG1120	ATPase activity
GO004_18185	COG0583	DNA-binding transcription factor activity
GO004_18190	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_18195	COG1942	4-Oxalocrotonate Tautomerase
GO004_18200	COG0477	Major facilitator Superfamily
GO004_18205	COG1846	Transcriptional regulator
GO004_18210	COG5577	PFAM Coat F domain
GO004_18220	COG0506	proline dehydrogenase activity
GO004_18230	COG1024	Enoyl-CoA hydratase
GO004_18230	COG1250	3-hydroxyacyl-CoA dehydrogenase
GO004_18235	COG0183	Belongs to the thiolase family
GO004_18240	COG1960	acyl-CoA dehydrogenase activity
GO004_18245	COG1393	Belongs to the ArsC family
GO004_18250	COG0509	glycine decarboxylation via glycine cleavage system
GO004_18260	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
GO004_18265	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO004_18275	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
GO004_18280	COG2011	ABC-type metal ion transport system permease component
GO004_18285	COG1464	Belongs to the NlpA lipoprotein family
GO004_18290	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
GO004_18300	COG0396	ATPase activity
GO004_18305	COG0719	Fe-S assembly protein
GO004_18310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
GO004_18315	COG0822	iron-sulfur transferase activity
GO004_18320	COG0719	Fe-S assembly protein
GO004_18335	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
GO004_18340	COG0322	excinuclease ABC activity
GO004_18345	COG2222	sugar isomerase
GO004_18350	COG1653	transport
GO004_18355	COG1175	transmembrane transport
GO004_18360	COG0395	ABC-type sugar transport system, permease component
GO004_18365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
GO004_18370	COG2188	Transcriptional regulator
GO004_18375	COG3842	ATPase activity
GO004_18380	COG2356	endonuclease I
GO004_18390	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GO004_18395	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
GO004_18400	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
GO004_18405	COG2068	MobA-Related Protein
GO004_18410	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
GO004_18415	COG1529	Aldehyde oxidase and xanthine dehydrogenase
GO004_18420	COG2080	2 iron, 2 sulfur cluster binding
GO004_18430	COG2351	hydroxyisourate hydrolase activity
GO004_18435	COG3648	Uricase
GO004_18435	COG3195	allantoin biosynthetic process
GO004_18440	COG2233	PERMEase
GO004_18445	COG2233	PERMEase
GO004_18450	COG2508	Transcriptional regulator
GO004_18455	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
GO004_18465	COG1801	Protein of unknown function DUF72
GO004_18470	COG0730	response to heat
GO004_18475	COG0737	Belongs to the 5'-nucleotidase family
GO004_18480	COG3377	Domain of unknown function (DUF1805)
GO004_18490	COG0739	heme binding
GO004_18495	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
GO004_18505	COG4470	Protein conserved in bacteria
GO004_18510	COG2445	Protein of unknown function DUF86
GO004_18515	COG0647	UMP catabolic process
GO004_18520	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
GO004_18525	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GO004_18530	COG0460	homoserine dehydrogenase
GO004_18535	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
GO004_18540	COG0083	homoserine kinase activity
GO004_18545	COG1506	peptidase
GO004_18545	COG4946	Tricorn protease homolog
GO004_18545	COG0823	Involved in the tonB-independent uptake of proteins
GO004_18550	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
GO004_18555	COG4837	Protein of unknown function (DUF1462)
GO004_18560	COG1252	NADH dehydrogenase
GO004_18565	COG4844	belongs to the
GO004_18570	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
GO004_18575	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
GO004_18580	COG0316	Belongs to the HesB IscA family
GO004_18585	COG0456	acetyltransferase
GO004_18590	COG2808	Putative FMN-binding domain
GO004_18595	COG0516	GMP reductase activity
GO004_18605	COG0492	ferredoxin-NADP+ reductase activity
GO004_18610	COG1252	NADH dehydrogenase
GO004_18625	COG3584	3D domain protein
GO004_18630	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
GO004_18635	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
GO004_18640	COG2056	Na+-H+ antiporter family
GO004_18645	COG1268	BioY protein
GO004_18650	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
GO004_18655	COG2819	hydrolase of the alpha beta superfamily
GO004_18660	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_18665	COG1169	isochorismate synthase
GO004_18670	COG1021	2,3-dihydroxybenzoate-AMP ligase
GO004_18675	COG1535	isochorismatase
GO004_18675	COG3433	isochorismatase activity
GO004_18680	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
GO004_18685	COG3251	PFAM MbtH domain protein
GO004_18690	COG5634	Uncharacterized conserved protein (DUF2278)
GO004_18695	COG0686	Belongs to the AlaDH PNT family
GO004_18700	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
GO004_18700	COG2508	Transcriptional regulator
GO004_18705	COG4842	Belongs to the WXG100 family
GO004_18710	COG5417	Belongs to the EsaB family
GO004_18715	COG4499	WXG100 protein secretion system (Wss), protein YukC
GO004_18720	COG0433	COG0433 Predicted ATPase
GO004_18720	COG1674	ftsk spoiiie
GO004_18725	COG1511	domain protein
GO004_18735	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_18740	COG1418	mRNA catabolic process
GO004_18755	COG0628	permease
GO004_18770	COG5506	Protein of unknown function (DUF1694)
GO004_18775	COG1335	isochorismatase
GO004_18780	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
GO004_18785	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
GO004_18805	COG0142	geranyltranstransferase activity
GO004_18815	COG4585	Histidine kinase
GO004_18820	COG2197	response regulator
GO004_18825	COG2050	protein possibly involved in aromatic compounds catabolism
GO004_18830	COG1320	monovalent cation:proton antiporter activity
GO004_18835	COG2212	antiporter activity
GO004_18840	COG1863	multisubunit Na H antiporter MnhE subunit
GO004_18845	COG0651	ATP synthesis coupled electron transport
GO004_18850	COG1006	Multisubunit Na H antiporter MnhC subunit
GO004_18855	COG2111	Na H antiporter
GO004_18860	COG2111	Na H antiporter
GO004_18860	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
GO004_18870	COG3493	citrate carrier protein
GO004_18875	COG1079	Belongs to the binding-protein-dependent transport system permease family
GO004_18880	COG4603	Belongs to the binding-protein-dependent transport system permease family
GO004_18885	COG3845	ABC transporter
GO004_18890	COG1744	ABC transporter substrate-binding protein PnrA-like
GO004_18895	COG4565	transcriptional regulatory protein
GO004_18900	COG3290	protein histidine kinase activity
GO004_18910	COG3011	Protein conserved in bacteria
GO004_18915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
GO004_18920	COG2814	Major facilitator Superfamily
GO004_18930	COG5018	Exonuclease
GO004_18940	COG2205	protein histidine kinase activity
GO004_18945	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
GO004_18955	COG2267	carboxylic ester hydrolase activity
GO004_18960	COG1522	sequence-specific DNA binding
GO004_18965	COG0436	Aminotransferase
GO004_18970	COG1098	S1 RNA binding domain
GO004_18975	COG2155	Conserved Protein
GO004_18980	COG1979	alcohol dehydrogenase
GO004_18985	COG1979	alcohol dehydrogenase
GO004_18990	COG0166	Belongs to the GPI family
GO004_19005	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
GO004_19020	COG2738	Putative neutral zinc metallopeptidase
GO004_19025	COG1253	flavin adenine dinucleotide binding
GO004_19030	COG0366	Alpha amylase catalytic
GO004_19040	COG0432	Pfam Uncharacterised protein family UPF0047
GO004_19055	COG0840	transmembrane signaling receptor activity
GO004_19060	COG0840	transmembrane signaling receptor activity
GO004_19065	COG0840	transmembrane signaling receptor activity
GO004_19070	COG0840	transmembrane signaling receptor activity
GO004_19075	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_19075	COG3347	Dehydrogenase
GO004_19080	COG1349	DNA-binding transcription factor activity
GO004_19085	COG1070	Carbohydrate kinase
GO004_19090	COG3254	rhamnose metabolic process
GO004_19095	COG4806	L-rhamnose isomerase
GO004_19100	COG0673	inositol 2-dehydrogenase activity
GO004_19105	COG0628	permease
GO004_19110	COG1968	undecaprenyl-diphosphatase activity
GO004_19120	COG5553	Cysteine dioxygenase type I
GO004_19125	COG0477	Major facilitator Superfamily
GO004_19130	COG1705	Flagellar rod assembly protein muramidase FlgJ
GO004_19135	COG4682	membrane
GO004_19140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
GO004_19145	COG0569	domain protein
GO004_19155	COG1510	regulation of RNA biosynthetic process
GO004_19160	COG1012	belongs to the aldehyde dehydrogenase family
GO004_19165	COG1454	alcohol dehydrogenase
GO004_19175	COG2318	DinB family
GO004_19180	COG1585	Membrane protein implicated in regulation of membrane protease activity
GO004_19185	COG2268	Band 7 protein
GO004_19190	COG1247	-acetyltransferase
GO004_19195	COG3859	Proton-coupled thiamine transporter YuaJ
GO004_19320	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
GO004_19325	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GO004_19330	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
GO004_19335	COG0297	glycogen (starch) synthase activity
GO004_19340	COG0058	SHG alpha-glucan phosphorylase activity
GO004_19345	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
GO004_19350	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GO004_19355	COG0438	transferase activity, transferring glycosyl groups
GO004_19360	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GO004_19370	COG0438	transferase activity, transferring glycosyl groups
GO004_19375	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO004_19380	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
GO004_19385	COG1210	Utp--glucose-1-phosphate uridylyltransferase
GO004_19390	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
GO004_19395	COG1169	isochorismate synthase
GO004_19400	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
GO004_19405	COG0596	Alpha beta hydrolase
GO004_19410	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
GO004_19415	COG0318	PFAM AMP-dependent synthetase and ligase
GO004_19420	COG4948	Mandelate Racemase Muconate Lactonizing
GO004_19425	COG0803	Belongs to the bacterial solute-binding protein 9 family
GO004_19430	COG1121	(ABC) transporter
GO004_19435	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GO004_19435	COG1321	iron dependent repressor
GO004_19440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
GO004_19450	COG1294	oxidase, subunit
GO004_19455	COG1271	oxidase subunit
GO004_19460	COG0254	rRNA binding
GO004_19465	COG0288	reversible hydration of carbon dioxide
GO004_19470	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
GO004_19475	COG1854	S-ribosylhomocysteine lyase activity
GO004_19490	COG0783	Belongs to the Dps family
GO004_19495	COG4824	toxin secretion phage lysis holin
GO004_19500	COG0494	nUDIX hydrolase
GO004_19505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
GO004_19510	COG1116	anion transmembrane transporter activity
GO004_19515	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
GO004_19520	COG1506	peptidase
GO004_19530	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
GO004_19535	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
GO004_19540	COG0367	asparagine synthase
GO004_19545	COG1113	amino acid transport
GO004_19550	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
GO004_19555	COG2267	carboxylic ester hydrolase activity
GO004_19565	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
GO004_19570	COG1242	4 iron, 4 sulfur cluster binding
GO004_19585	COG1725	Transcriptional regulator
GO004_19590	COG1131	(ABC) transporter
GO004_19605	COG1136	(ABC) transporter
GO004_19610	COG0577	efflux transmembrane transporter activity
GO004_19615	COG0745	RESPONSE REGULATOR receiver
GO004_19620	COG2205	protein histidine kinase activity
GO004_19625	COG1136	(ABC) transporter
GO004_19630	COG0577	efflux transmembrane transporter activity
GO004_19635	COG2433	Pfam Transposase IS66
GO004_19640	COG2814	Major facilitator Superfamily
GO004_19645	COG2202	Pas domain
GO004_19645	COG1366	Belongs to the anti-sigma-factor antagonist family
GO004_19655	COG0495	leucyl-tRNA aminoacylation
GO004_19660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
GO004_19665	COG1486	melibiose metabolic process
GO004_19670	COG0395	ABC-type sugar transport system, permease component
GO004_19675	COG1175	transmembrane transport
GO004_19680	COG1653	transport
GO004_19685	COG1609	Transcriptional regulator
GO004_19690	COG1073	alpha beta
GO004_19700	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
GO004_19705	COG0156	8-amino-7-oxononanoate synthase activity
GO004_19715	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
GO004_19720	COG2124	cytochrome p450
GO004_19725	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
GO004_19730	COG0395	ABC-type sugar transport system, permease component
GO004_19735	COG1653	transport
GO004_19740	COG2207	Transcriptional regulator
GO004_19745	COG4209	transmembrane transport
GO004_19750	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
GO004_19755	COG1653	transport
GO004_19760	COG0673	inositol 2-dehydrogenase activity
GO004_19765	COG5578	integral membrane protein
GO004_19775	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
GO004_19780	COG2081	HI0933 family
GO004_19785	COG2244	polysaccharide biosynthetic process
GO004_19790	COG1187	pseudouridine synthase activity
GO004_19795	COG1349	DNA-binding transcription factor activity
GO004_19800	COG1131	(ABC) transporter
GO004_19805	COG4473	ABC transporter
GO004_19810	COG2252	PERMEase
GO004_19815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
GO004_19820	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GO004_19825	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
GO004_19835	COG1597	lipid kinase activity
GO004_19840	COG1523	belongs to the glycosyl hydrolase 13 family
GO004_19845	COG0510	thiamine kinase activity
GO004_19855	COG0220	tRNA (guanine-N7-)-methyltransferase activity
GO004_19860	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
GO004_19865	COG0281	malic enzyme
GO004_19870	COG5584	Small secreted protein
GO004_19875	COG1363	Peptidase, m42
GO004_19890	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
GO004_19895	COG4848	Belongs to the UPF0354 family
GO004_19900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO004_19905	COG1674	ftsk spoiiie
GO004_19910	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
GO004_19915	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
GO004_19920	COG4980	gas vesicle protein
GO004_19925	COG3118	belongs to the thioredoxin family
GO004_19930	COG1605	Chorismate mutase
GO004_19930	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
GO004_19935	COG1609	Transcriptional regulator
GO004_19940	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
GO004_19945	COG1360	Flagellar Motor Protein
GO004_19950	COG0123	including yeast histone deacetylase and acetoin utilization protein
GO004_19955	COG0517	IMP dehydrogenase activity
GO004_19960	COG0454	-acetyltransferase
GO004_19965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GO004_19970	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
GO004_19975	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
GO004_19985	COG2203	Gaf domain
GO004_19985	COG2199	diguanylate cyclase activity
GO004_19990	COG1956	GAF domain-containing protein
GO004_19995	COG1309	transcriptional regulator
GO004_20000	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GO004_20005	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
GO004_20010	COG1114	Component of the transport system for branched-chain amino acids
GO004_20015	COG1104	cysteine desulfurase activity
GO004_20020	COG0301	tRNA thio-modification
GO004_20030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
GO004_20035	COG1574	metal-dependent hydrolase with the TIM-barrel fold
GO004_20040	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
GO004_20045	COG0616	signal peptide processing
GO004_20050	COG1714	RDD family
GO004_20060	COG3874	Sporulation protein YtfJ
GO004_20065	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
GO004_20070	COG0827	DNA restriction-modification system
GO004_20080	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
GO004_20085	COG0521	Mo-molybdopterin cofactor biosynthetic process
GO004_20090	COG0137	argininosuccinate synthase activity
GO004_20095	COG0165	Argininosuccinate lyase
GO004_20105	COG1028	Short-chain dehydrogenase reductase Sdr
GO004_20110	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
GO004_20115	COG0583	DNA-binding transcription factor activity
GO004_20120	COG0454	-acetyltransferase
GO004_20125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO004_20130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO004_20135	COG0765	amino acid transport
GO004_20140	COG0765	amino acid transport
GO004_20145	COG1126	abc transporter atp-binding protein
GO004_20150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO004_20155	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
GO004_20160	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
GO004_20170	COG1473	amidohydrolase
GO004_20175	COG0730	response to heat
GO004_20180	COG4109	DRTGG domain
GO004_20190	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
GO004_20210	COG0587	DNA-directed DNA polymerase activity
GO004_20215	COG0281	malic enzyme
GO004_20220	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
GO004_20225	COG0825	malonyl-CoA metabolic process
GO004_20230	COG0205	6-phosphofructokinase activity
GO004_20235	COG0469	pyruvate kinase activity
GO004_20240	COG3030	protein affecting phage T7 exclusion by the F plasmid
GO004_20245	COG0628	permease
GO004_20250	COG2707	UPF0756 membrane protein
GO004_20255	COG0372	Belongs to the citrate synthase family
GO004_20260	COG0538	isocitrate dehydrogenase activity
GO004_20265	COG0039	L-malate dehydrogenase activity
GO004_20270	COG0745	RESPONSE REGULATOR receiver
GO004_20275	COG5002	protein histidine kinase activity
GO004_20280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GO004_20280	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
GO004_20285	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
GO004_20290	COG1971	Probably functions as a manganese efflux pump
GO004_20295	COG0237	dephospho-CoA kinase activity
GO004_20300	COG0656	L-ascorbic acid biosynthetic process
GO004_20305	COG2814	Major facilitator Superfamily
GO004_20310	COG1733	regulation of RNA biosynthetic process
GO004_20315	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO004_20320	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
GO004_20325	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
GO004_20330	COG3611	Membrane attachment protein
GO004_20335	COG1484	DNA-dependent DNA replication
GO004_20340	COG0398	Pfam SNARE associated Golgi protein
GO004_20350	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
GO004_20355	COG1011	Hydrolase
GO004_20360	COG3275	phosphorelay sensor kinase activity
GO004_20365	COG3279	Response regulator of the LytR AlgR family
GO004_20370	COG1380	Effector of murein hydrolase LrgA
GO004_20375	COG1346	cytolysis
GO004_20385	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
GO004_20390	COG0291	Belongs to the bacterial ribosomal protein bL35 family
GO004_20395	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
GO004_20400	COG3326	Membrane
GO004_20410	COG1363	Peptidase, m42
GO004_20415	COG3507	Belongs to the glycosyl hydrolase 43 family
GO004_20420	COG2160	L-arabinose isomerase activity
GO004_20425	COG1069	ribulokinase activity
GO004_20430	COG0235	Class ii aldolase
GO004_20435	COG0647	UMP catabolic process
GO004_20440	COG0371	Dehydrogenase
GO004_20445	COG1653	transport
GO004_20450	COG1175	transmembrane transport
GO004_20455	COG0395	ABC-type sugar transport system, permease component
GO004_20460	COG3534	alpha-L-arabinofuranosidase
GO004_20465	COG1966	Carbon starvation protein
GO004_20480	COG0247	lactate metabolic process
GO004_20485	COG0277	FAD linked oxidase domain protein
GO004_20490	COG3835	regulator
GO004_20500	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
GO004_20510	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
GO004_20515	COG0072	phenylalanine-tRNA ligase activity
GO004_20515	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
GO004_20520	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
GO004_20525	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
GO004_20530	COG1286	toxin biosynthetic process
GO004_20535	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
GO004_20535	COG1796	DNA polymerase
GO004_20540	COG1193	negative regulation of DNA recombination
GO004_20545	COG3766	membrane
GO004_20550	COG0318	PFAM AMP-dependent synthetase and ligase
GO004_20555	COG1309	transcriptional regulator
GO004_20560	COG1024	Enoyl-CoA hydratase
GO004_20565	COG2086	electron transfer activity
GO004_20570	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
GO004_20575	COG3534	alpha-L-arabinofuranosidase
GO004_20580	COG3118	belongs to the thioredoxin family
GO004_20585	COG0322	excinuclease ABC activity
GO004_20590	COG0527	aspartate kinase activity
GO004_20595	COG1719	4-vinyl reductase, 4VR
GO004_20600	COG2009	succinate dehydrogenase
GO004_20605	COG1053	succinate dehydrogenase
GO004_20610	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
GO004_20615	COG0824	Thioesterase
GO004_20620	COG2197	response regulator
GO004_20625	COG1846	Transcriptional regulator
GO004_20630	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
GO004_20635	COG5401	PFAM Sporulation and spore germination
GO004_20640	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
GO004_20645	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
GO004_20650	COG0622	Phosphoesterase
GO004_20660	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
GO004_20665	COG0454	-acetyltransferase
GO004_20675	COG0028	Belongs to the TPP enzyme family
GO004_20680	COG0440	acetolactate synthase activity
GO004_20685	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
GO004_20690	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
GO004_20695	COG0473	3-isopropylmalate dehydrogenase activity
GO004_20700	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
GO004_20705	COG0066	3-isopropylmalate dehydratase activity
GO004_20710	COG1477	protein flavinylation
GO004_20710	COG0457	Tetratricopeptide repeat
GO004_20715	COG0544	peptidyl-prolyl cis-trans isomerase activity
GO004_20720	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
GO004_20725	COG1067	ATP-dependent peptidase activity
GO004_20725	COG0470	DNA polymerase III
GO004_20730	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
GO004_20735	COG0218	Necessary for normal cell division and for the maintenance of normal septation
GO004_20745	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
GO004_20750	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
GO004_20755	COG0181	hydroxymethylbilane synthase activity
GO004_20760	COG1587	Uroporphyrinogen-III synthase
GO004_20765	COG0113	porphobilinogen synthase activity
GO004_20770	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
GO004_20775	COG1388	LysM domain
GO004_20780	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
GO004_20790	COG0525	valine-tRNA ligase activity
GO004_20795	COG0285	dihydrofolate synthase activity
GO004_20800	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
GO004_20810	COG0424	maF-like protein
GO004_20815	COG2003	Belongs to the UPF0758 family
GO004_20830	COG1396	sequence-specific DNA binding
GO004_20985	COG3953	SLT domain
GO004_20985	COG5412	phage tail tape measure protein
GO004_21000	COG5434	Belongs to the glycosyl hydrolase 28 family
GO004_21025	COG4824	toxin secretion phage lysis holin
GO004_21030	COG3409	Peptidoglycan-binding domain 1 protein
GO004_21030	COG1388	LysM domain
GO004_21030	COG5632	N-Acetylmuramoyl-L-alanine amidase
GO004_21055	COG1077	Cell shape determining protein MreB Mrl
GO004_21065	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
GO004_21070	COG0850	regulation of cytokinetic process
GO004_21075	COG2894	cell division
GO004_21080	COG0739	heme binding
GO004_21085	COG1994	Peptidase M50
GO004_21090	COG0261	This protein binds to 23S rRNA in the presence of protein L20
GO004_21095	COG2868	ribosomal protein
GO004_21100	COG0211	Belongs to the bacterial ribosomal protein bL27 family
GO004_21110	COG3290	protein histidine kinase activity
GO004_21115	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
GO004_21120	COG4492	Belongs to the UPF0735 family
GO004_21125	COG0077	Prephenate dehydratase
GO004_21130	COG1827	regulation of RNA biosynthetic process
GO004_21135	COG1104	cysteine desulfurase activity
GO004_21140	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
GO004_21145	COG0157	Belongs to the NadC ModD family
GO004_21150	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
GO004_21155	COG1388	LysM domain
GO004_21165	COG0217	transcriptional regulatory protein
GO004_21170	COG1115	amino acid carrier protein
GO004_21190	COG2112	serine threonine protein kinase
GO004_21195	COG0673	inositol 2-dehydrogenase activity
GO004_21200	COG2814	Major facilitator Superfamily
GO004_21210	COG0632	four-way junction helicase activity
GO004_21215	COG2255	four-way junction helicase activity
GO004_21225	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
GO004_21230	COG0343	queuine tRNA-ribosyltransferase activity
GO004_21235	COG1862	Preprotein translocase
GO004_21245	COG2323	membrane
GO004_21250	COG2244	polysaccharide biosynthetic process
GO004_21260	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GO004_21260	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
GO004_21265	COG0490	domain, Protein
GO004_21270	COG5416	Lipopolysaccharide assembly protein A domain
GO004_21275	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
GO004_21275	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
GO004_21280	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
GO004_21285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
GO004_21290	COG1490	D-aminoacyl-tRNA deacylase activity
GO004_21295	COG4991	sh3 domain protein
GO004_21295	COG3103	Sh3 type 3 domain protein
GO004_21295	COG0860	N-Acetylmuramoyl-L-alanine amidase
GO004_21305	COG0124	histidyl-tRNA synthetase
GO004_21310	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
GO004_21320	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
GO004_21325	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
GO004_21330	COG1959	2 iron, 2 sulfur cluster binding
GO004_21335	COG1104	cysteine desulfurase activity
GO004_21340	COG0482	sulfurtransferase activity
GO004_21345	COG0457	Tetratricopeptide repeat
GO004_21350	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
GO004_21355	COG3881	PFAM PRC-barrel domain
GO004_21370	COG0765	amino acid transport
GO004_21375	COG0765	amino acid transport
GO004_21380	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
GO004_21385	COG1126	abc transporter atp-binding protein
GO004_21390	COG0628	permease
GO004_21395	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
GO004_21400	COG4472	Bacterial protein of unknown function (DUF965)
GO004_21405	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
GO004_21410	COG3906	Belongs to the UPF0473 family
GO004_21415	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
GO004_21420	COG4122	O-methyltransferase activity
GO004_21425	COG0826	peptidase U32
GO004_21430	COG0826	peptidase U32
GO004_21435	COG0572	uridine kinase
GO004_21440	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
GO004_21445	COG0768	penicillin binding
GO004_21460	COG2226	methyltransferase
GO004_21465	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
GO004_21470	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
GO004_21475	COG0626	cystathionine gamma-synthase activity
GO004_21485	COG2427	Protein of unknown function (DUF1641)
GO004_21490	COG3383	formate dehydrogenase (NAD+) activity
GO004_21495	COG5609	conserved protein (DUF2294)
GO004_21500	COG2116	formate transmembrane transporter activity
GO004_21515	COG2226	methyltransferase
GO004_21520	COG1309	transcriptional regulator
GO004_21525	COG2124	cytochrome p450
GO004_21525	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
GO004_21535	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
GO004_21535	COG2755	lipolytic protein G-D-S-L family
GO004_21545	COG1595	DNA-templated transcription, initiation
GO004_21550	COG1378	Sugar-specific transcriptional regulator TrmB
GO004_21555	COG1280	lysine exporter protein (LysE YggA)
GO004_21560	COG1113	amino acid transport
GO004_21570	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
GO004_21570	COG3933	PFAM sigma-54 factor interaction domain-containing protein
GO004_21575	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
GO004_21580	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
GO004_21585	COG3715	PTS system
GO004_21590	COG3716	PTS system mannose fructose sorbose family IID component
GO004_21595	COG1621	beta-fructofuranosidase activity
GO004_21600	COG0693	protein deglycase activity
GO004_21605	COG1064	alcohol dehydrogenase
GO004_21615	COG0789	Transcriptional regulator
GO004_21620	COG5577	PFAM Coat F domain
GO004_21630	COG1063	alcohol dehydrogenase
GO004_21635	COG5577	PFAM Coat F domain
GO004_21645	COG0346	lactoylglutathione lyase activity
GO004_21655	COG4991	sh3 domain protein
GO004_21660	COG4991	sh3 domain protein
GO004_21665	COG0596	Alpha beta hydrolase
GO004_21670	COG5566	PFAM Mor transcription activator
GO004_21675	COG3409	Peptidoglycan-binding domain 1 protein
GO004_21680	COG2828	Protein conserved in bacteria
GO004_21685	COG0583	DNA-binding transcription factor activity
GO004_21690	COG2851	Citrate transporter
GO004_21695	COG0667	Aldo Keto reductase
GO004_21700	COG1595	DNA-templated transcription, initiation
GO004_21705	COG3443	Belongs to the bacterial solute-binding protein 9 family
GO004_21715	COG2315	Protein conserved in bacteria