locus-tag class description HGH94_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) HGH94_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HGH94_00015 ENOG410848D S4 domain protein YaaA HGH94_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HGH94_00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HGH94_00080 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) HGH94_00085 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) HGH94_00090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) HGH94_00100 ENOG4105ZMH deoxynucleoside kinase HGH94_00110 ENOG4105VRS hydrolase family 18 HGH94_00115 ENOG4105GTG Isochorismatase HGH94_00120 ENOG4108Z6B deaminase HGH94_00130 ENOG4105C6E dna polymerase iii HGH94_00135 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) HGH94_00140 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) HGH94_00150 ENOG41067KS pro-sigma K processing HGH94_00190 ENOG4105CDW Resistance protein HGH94_00195 ENOG4105CXN decarboxylase HGH94_00200 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) HGH94_00205 ENOG4105X0R protein from nitrogen regulatory protein P-II HGH94_00210 ENOG4105XVJ Protein of unknown function (DUF327) HGH94_00220 ENOG4105MA4 psp1 domain protein HGH94_00225 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) HGH94_00230 ENOG41060K3 Methyltransferase HGH94_00235 ENOG4105VC4 domain protein HGH94_00240 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HGH94_00245 ENOG4105KRN Transcriptional regulator, abrb family HGH94_00250 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HGH94_00255 ENOG4105F8V Hydrolase, tatD family HGH94_00260 ENOG41069ER domain protein HGH94_00270 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) HGH94_00275 ENOG4105XFA sporulation peptidase YabG HGH94_00280 ENOG4105W42 Veg protein HGH94_00285 ENOG4105XEW small acid-soluble spore protein HGH94_00290 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HGH94_00300 ENOG4105KME endoribonuclease L-psp HGH94_00305 ENOG4105K4W Could be involved in septation (By similarity) HGH94_00310 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HGH94_00315 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HGH94_00320 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) HGH94_00325 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) HGH94_00335 ENOG4108JA2 transcriptioN-repair coupling factor HGH94_00340 ENOG4108M14 stage v sporulation protein t HGH94_00350 ENOG4108IY2 MazG family HGH94_00355 ENOG41082I2 s4 domain protein HGH94_00360 ENOG4105VYY sporulation protein yabp HGH94_00375 ENOG41060GV RNA binding s1 domain protein HGH94_00405 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HGH94_00410 ENOG4108UGV hypoxanthine phosphoribosyltransferase HGH94_00415 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HGH94_00430 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase HGH94_00435 ENOG4105C6T cysteine synthase HGH94_00440 ENOG4105CRQ synthase (Component I) HGH94_00455 ENOG4105EEI dihydropteroate synthase HGH94_00460 ENOG4105KRF dihydroneopterin aldolase HGH94_00465 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HGH94_00475 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HGH94_00480 ENOG4105CRK lysyL-tRNA synthetase HGH94_00570 ENOG41066A3 ATP guanido phosphotransferase HGH94_00580 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HGH94_00585 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) HGH94_00590 ENOG4105CTP PilT protein domain protein HGH94_00600 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) HGH94_00610 ENOG4105D7W serine acetyltransferase HGH94_00615 ENOG4105C8N cysteinyl-tRNA synthetase HGH94_00620 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) HGH94_00625 ENOG4105C2N RNA methyltransferase TrmH family group 3 HGH94_00630 ENOG4105M0M Tetracycline resistance protein HGH94_00650 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HGH94_00665 ENOG4108VZM 50s ribosomal protein L10 HGH94_00675 ENOG4107Y49 methyltransferase HGH94_00680 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HGH94_00685 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HGH94_00690 ENOG4105XPM ribosomal protein HGH94_00695 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) HGH94_00705 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) HGH94_00710 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) HGH94_00715 ENOG4107SKW Inherit from COG: Alpha beta hydrolase HGH94_00720 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) HGH94_00725 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) HGH94_00730 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) HGH94_00740 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity HGH94_00755 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) HGH94_00760 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) HGH94_00770 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal HGH94_00785 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits HGH94_00795 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) HGH94_00800 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) HGH94_00805 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) HGH94_00810 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) HGH94_00820 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) HGH94_00825 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HGH94_00835 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HGH94_00850 ENOG41067V7 50S ribosomal protein L36 HGH94_00855 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits HGH94_00860 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) HGH94_00865 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) HGH94_00870 ENOG4108ZT0 50S ribosomal protein l17 HGH94_00875 ENOG4108JJB ABC transporter HGH94_00880 ENOG4108JJB ABC transporter HGH94_00885 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) HGH94_00890 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) HGH94_00895 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) HGH94_00900 ENOG4108UJD 30S ribosomal protein S9 HGH94_00905 ENOG4108I0C methyltransferase HGH94_00920 ENOG4105D1F ATP-binding protein HGH94_00935 ENOG4108NMV polysaccharide deacetylase HGH94_01020 ENOG4105CHH sulfate transporter HGH94_01030 ENOG4108SA1 esterase HGH94_01050 ENOG410874W AraC family transcriptional regulator HGH94_01055 ENOG4105EHZ conserved protein UCP016719 HGH94_01060 ENOG4105D17 glycoside hydrolase, family 3 domain protein HGH94_01080 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HGH94_01090 ENOG4105EWC Purine nucleoside phosphorylase HGH94_01120 ENOG4105EMN RNA polymerase sigma factor HGH94_01130 ENOG4105C8B TIGR00159 family HGH94_01135 ENOG4107U5W ybbr family HGH94_01140 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) HGH94_01145 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HGH94_01155 ENOG4105D03 DNA-3-methyladenine glycosylase II HGH94_01165 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HGH94_01170 ENOG4108TWJ NADH dehydrogenase subunit 5 HGH94_01190 ENOG4105GPN Uncharacterized conserved protein (DUF2294) HGH94_01195 ENOG4105WAB arsR family transcriptional regulator HGH94_01200 ENOG4108RWP Major Facilitator Superfamily protein HGH94_01210 ENOG4107ZBH radical SAM domain protein HGH94_01215 ENOG41066N6 Abortive infection protein HGH94_01220 ENOG4108WUZ (ABC) transporter HGH94_01270 ENOG4106K80 HGH94_01280 ENOG4106DDH Sporulation-specific SASP protein HGH94_01290 ENOG4108HWY Beta-lactamase HGH94_01305 ENOG4107QTZ amino acid HGH94_01310 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HGH94_01325 ENOG410645S MarR family Transcriptional regulator HGH94_01330 ENOG4105DCM major facilitator superfamily HGH94_01350 ENOG4106AXJ AraC family transcriptional regulator HGH94_01355 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HGH94_01360 ENOG4108TCS Glutamyl endopeptidase HGH94_01370 ENOG4108WC5 Alpha Beta Hydrolase Fold protein HGH94_01375 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase HGH94_01380 ENOG4107ZTW SNARE associated Golgi HGH94_01400 ENOG4105C72 UPF0176 protein HGH94_01410 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane HGH94_01430 ENOG4105CM2 brancheD-chain amino acid aminotransferase HGH94_01435 ENOG4108IQI permease HGH94_01440 ENOG4108J5H Homocysteine s-methyltransferase HGH94_01455 ENOG4105CSV Glutaminase HGH94_01470 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase HGH94_01475 ENOG4105C26 Dehydrogenase HGH94_01485 ENOG4105EQX glucarate dehydratase HGH94_01490 ENOG41073TP transcriptional regulator HGH94_01510 ENOG4106UX7 integral membrane protein HGH94_01515 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HGH94_01555 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HGH94_01580 ENOG4107QK3 aspartate-semialdehyde dehydrogenase (EC 1.2.1.11 HGH94_01585 ENOG4105DVH amino acid HGH94_01600 ENOG4105CDH Citrulline--aspartate ligase HGH94_01605 ENOG4105C28 cystathionine HGH94_01610 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HGH94_01630 ENOG4105DGI Alkaline phosphatase HGH94_01635 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HGH94_01640 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HGH94_01645 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) HGH94_01650 ENOG4107EPV Aminotransferase class V HGH94_01655 ENOG4105C0R drug resistance transporter emrb qaca subfamily HGH94_01660 ENOG4105J7D transcriptional regulator HGH94_01665 ENOG4107RB3 L-asparaginase HGH94_01670 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold HGH94_01680 ENOG41060AI SEC-C motif HGH94_01690 ENOG4107Y7X LytTR HGH94_01695 ENOG4108IUW ABC transporter HGH94_01700 ENOG4108SDH ABC, transporter HGH94_01750 ENOG4105DSE periplasmic solute binding protein HGH94_01755 ENOG4105DIK (ABC) transporter HGH94_01765 ENOG4105DEN Luciferase family HGH94_01770 ENOG4108N0M stress protein HGH94_01775 ENOG4106FN3 tellurium resistance protein HGH94_01780 ENOG4106FN3 tellurium resistance protein HGH94_01785 ENOG4107TS3 membrane protein, TerC HGH94_01790 ENOG4108TTB tellurium resistance protein HGH94_01800 ENOG41079KZ Major Facilitator Superfamily HGH94_01805 ENOG4107XZQ multidrug resistance protein HGH94_01810 ENOG4108A65 Transcriptional regulator HGH94_01815 ENOG4108IJ7 Glycine betaine HGH94_01820 ENOG4107SQ8 Glycine betaine HGH94_01855 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HGH94_01895 ENOG4107RA1 nh(3)-dependent nad( ) synthetase HGH94_01905 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) HGH94_01910 ENOG41089UC methyltransferase, type 11 HGH94_01915 ENOG4105C5Q Transcriptional regulator HGH94_01920 ENOG4105I82 acetyl xylan esterase HGH94_01925 ENOG410756H nucleotidyltransferase HGH94_01935 ENOG4105C26 Dehydrogenase HGH94_01940 ENOG4105CK7 Sodium proline symporter HGH94_01945 ENOG4107YHD transcriptional regulator HGH94_01955 ENOG4108PJD permease HGH94_01960 ENOG4105U6C Alpha beta hydrolase fold protein HGH94_01970 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HGH94_01975 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit HGH94_01980 ENOG4108IFG nitrite reductase, (NAD(P)H) HGH94_02005 ENOG4105S7A ErfK ybiS ycfS ynhG family protein HGH94_02025 ENOG4105E5Q amino acid AbC transporter HGH94_02030 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein HGH94_02040 ENOG4105HHM rdd domain containing protein HGH94_02070 ENOG41080HJ 6-phospho 3-hexuloisomerase HGH94_02075 ENOG4108VA3 3-hexulose-6-phosphate synthase HGH94_02080 ENOG4105KVH Transcriptional regulator HGH94_02085 ENOG4105CEY Amp-dependent synthetase and ligase HGH94_02125 ENOG4105W8Z 4'-phosphopantetheinyl transferase HGH94_02135 ENOG4105CDA abc transporter atp-binding protein HGH94_02140 ENOG4105DRP amino acid AbC transporter HGH94_02150 ENOG4106P55 Transcriptional regulator HGH94_02155 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HGH94_02160 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HGH94_02165 ENOG41069ZX HGH94_02170 ENOG41069ZX HGH94_02180 ENOG4105DUX Transporter HGH94_02195 ENOG4105E1K spore germination protein HGH94_02215 ENOG4107WD8 ABC transporter, permease HGH94_02220 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HGH94_02225 ENOG4105BZU Histidine kinase HGH94_02250 ENOG4105CFH Aspartokinase HGH94_02255 ENOG4105DHS permease protein HGH94_02260 ENOG4105CM4 permease protein HGH94_02265 ENOG4108IPW abc transporter atp-binding protein HGH94_02280 ENOG4105R8C Transcriptional regulator HGH94_02285 ENOG4108DBC nitroreductase HGH94_02290 ENOG41067V3 Antibiotic biosynthesis monooxygenase HGH94_02295 ENOG4105YVS arsR family transcriptional regulator HGH94_02305 ENOG4108JPW Aminotransferase HGH94_02310 ENOG4105C26 Dehydrogenase HGH94_02320 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HGH94_02325 ENOG4105KTB nuclear export factor GLE1 HGH94_02330 ENOG4108T5E Copper resistance protein HGH94_02335 ENOG4108ZYE Transcriptional regulator HGH94_02360 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HGH94_02365 ENOG4108ZX0 Signal peptidase I HGH94_02400 ENOG4105E7W lamb ycsf family protein HGH94_02405 ENOG4105C5A transporter HGH94_02410 ENOG4105CFM UPF0317 protein HGH94_02415 ENOG4105P4J Allophanate hydrolase, subunit 1 HGH94_02425 ENOG4107258 Transcriptional regulator HGH94_02430 ENOG4105XJB lipolytic protein G-D-S-L family HGH94_02445 ENOG4107RVG penicillin-binding protein HGH94_02450 ENOG4107QM2 Aldo Keto reductase HGH94_02455 ENOG4105ETD TRANSCRIPTIONal HGH94_02465 ENOG4105HMZ Methyltransferase HGH94_02470 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HGH94_02485 ENOG410606W general stress protein HGH94_02495 ENOG4105VCH membrane HGH94_02505 ENOG4105C9U ATP-dependent DNA helicase RecQ HGH94_02525 ENOG4107R8N Glycosyl transferase, family 2 HGH94_02535 ENOG4105C0X amino acid HGH94_02555 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) HGH94_02565 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) HGH94_02570 ENOG4105EU9 HGH94_02575 ENOG4105QVS general stress protein HGH94_02580 ENOG41082W1 Cupin 2, conserved barrel domain protein HGH94_02595 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HGH94_02600 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HGH94_02605 ENOG4108MRH transcriptional regulatory protein HGH94_02610 ENOG4107QJT sodium dicarboxylate symporter HGH94_02615 ENOG4106F5Q Membrane HGH94_02620 ENOG4105CJ1 ABC, transporter HGH94_02635 ENOG4105FDT acyl-CoA dehydrogenase HGH94_02655 ENOG4105SZ6 Thioredoxin HGH94_02660 ENOG4105CPF Cell wall formation (By similarity) HGH94_02665 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) HGH94_02670 ENOG4105C1J atp-dependent rna helicase HGH94_02675 ENOG410905X membrane-flanked domain protein HGH94_02680 ENOG4105CKV Membrane HGH94_02690 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HGH94_02695 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein HGH94_02700 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HGH94_02710 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) HGH94_02715 ENOG4107MMM Anti-sigma-factor antagonist HGH94_02720 ENOG4105FUA antagonist HGH94_02725 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase HGH94_02730 ENOG4107SGM protein serine threonine phosphatase HGH94_02740 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HGH94_02750 ENOG41064BQ Phosphatase HGH94_02820 ENOG4105VZ8 Transcriptional regulator HGH94_02830 ENOG4105ECK Fatty Acid Desaturase HGH94_02835 ENOG4105VEQ Cold shock protein HGH94_02850 ENOG4108MCI Transcriptional regulator, ARAC family HGH94_02855 ENOG4108UZ3 Transporter HGH94_02860 ENOG41086D8 Transcriptional regulator HGH94_02865 ENOG4107U9B transcriptional regulator HGH94_02875 ENOG4105CZ9 Domain of unknown function (DU1801) HGH94_02880 ENOG4105GIG HGH94_02885 ENOG4105KRI phosphocarrier protein (HPr HGH94_02890 ENOG4105ST3 Transcriptional regulator HGH94_02895 ENOG4105T38 integral membrane protein HGH94_02900 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HGH94_02905 ENOG4108ZMQ domain protein HGH94_02910 ENOG4105MJ9 esterase HGH94_02915 ENOG4107Z6X Transcriptional regulator HGH94_02925 ENOG41082YX Transcriptional regulator, arsr family HGH94_02930 ENOG4107R5R arsenical pump membrane protein HGH94_02935 ENOG4108UXE Protein tyrosine phosphatase HGH94_02940 ENOG4105Z7P Acetyltransferase (GNAT) family HGH94_02955 ENOG4108SQ9 flavin reductase domain protein, FMN-binding HGH94_02960 ENOG4108ZHR arsR family transcriptional regulator HGH94_02965 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HGH94_02980 ENOG4105ENE Histidine kinase HGH94_02985 ENOG4108VB1 regulatoR HGH94_02990 ENOG4105EYF MMPL domain protein HGH94_02995 ENOG4108UQV Membrane HGH94_03020 ENOG41076HS cation diffusion facilitator family transporter HGH94_03025 ENOG4108TVJ Nitroreductase HGH94_03030 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase HGH94_03035 ENOG4108VGI doxx family HGH94_03040 ENOG4105XXY Thioredoxin HGH94_03065 ENOG4108QY0 Membrane HGH94_03085 ENOG4105PF9 Transcriptional regulator HGH94_03095 ENOG4105WQG acetyltransferase HGH94_03105 ENOG4105C85 amino acid HGH94_03115 ENOG41062A4 Transcriptional regulator HGH94_03120 ENOG4105EYF MMPL domain protein HGH94_03125 ENOG4108TVJ Nitroreductase HGH94_03130 ENOG4105FS7 Transcriptional regulator HGH94_03135 ENOG4105C2C drug resistance transporter, Bcr CflA HGH94_03145 ENOG4105DRR Transcriptional regulator, GntR family HGH94_03150 ENOG4105VRS hydrolase family 18 HGH94_03165 ENOG4105G6Z alkaline phosphatase HGH94_03170 ENOG4108ZMX Domain of unknown function (DU1801) HGH94_03180 ENOG4108YM7 Gcn5-related n-acetyltransferase HGH94_03185 ENOG4107TVP HD domain protein HGH94_03190 ENOG41090UD (LipO)protein HGH94_03195 ENOG4105F27 Major Facilitator HGH94_03200 ENOG4105VZJ PTS System HGH94_03205 ENOG4105VCP PTS System HGH94_03210 ENOG4105CK1 PTS System HGH94_03215 ENOG4105CS2 ec 3.2.1.21 HGH94_03220 ENOG4108TZY GntR Family Transcriptional Regulator HGH94_03230 ENOG4105DG6 mannose-6-phosphate isomerase HGH94_03280 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HGH94_03285 ENOG4105K8N protein family UPF0079, ATPase HGH94_03290 ENOG41072GX Peptidase M22 Glycoprotease HGH94_03295 ENOG410801F ribosomal-protein-alanine acetyltransferase HGH94_03300 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HGH94_03305 ENOG4105C5H ABC transporter HGH94_03310 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HGH94_03315 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) HGH94_03320 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HGH94_03325 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HGH94_03335 ENOG4108TYN CAAX amino terminal protease family protein HGH94_03365 ENOG4106BHF HGH94_03375 ENOG4108SJC Membrane HGH94_03400 ENOG4105PGZ NB-ARC domain HGH94_03405 ENOG4105CPQ Dehydrogenase HGH94_03410 ENOG4105CT4 transporter HGH94_03420 ENOG41087YS Phage shock protein A HGH94_03425 ENOG4105DQX Zinc finger domain HGH94_03430 ENOG4108WV1 Pfam:DUF477 HGH94_03445 ENOG4107QNK )-transporter HGH94_03480 ENOG4107YUH hydrolase HGH94_03490 ENOG4107STQ Multicopper oxidase HGH94_03495 ENOG4105C85 amino acid HGH94_03545 ENOG4105C7N Xanthine uracil vitamin C permease HGH94_03570 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HGH94_03575 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HGH94_03580 ENOG4105C83 adenylosuccinate lyase HGH94_03585 ENOG4105C8V SAICAR synthetase HGH94_03590 ENOG4105VR9 phosphoribosylformylglycinamidine synthase HGH94_03595 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I HGH94_03600 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii HGH94_03610 ENOG4105CXB phosphoribosylaminoimidazole synthetase HGH94_03615 ENOG4108V3E phosphoribosylglycinamide formyltransferase HGH94_03620 ENOG4105DC1 bifunctional purine biosynthesis protein purh HGH94_03625 ENOG4105C12 Phosphoribosylglycinamide synthetase HGH94_03650 ENOG4108R5T secreted protein HGH94_03655 ENOG4105KGF protein, YerC YecD HGH94_03660 ENOG4105CBC glutamate synthase HGH94_03665 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) HGH94_03670 ENOG4105C4R Atp-dependent dna helicase HGH94_03675 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HGH94_03690 ENOG4105CRN Aminoglycoside phosphotransferase HGH94_03695 ENOG4105KT7 mgtC SapB transporter HGH94_03700 ENOG4105CK7 Sodium proline symporter HGH94_03705 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HGH94_03710 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HGH94_03715 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) HGH94_03720 ENOG4108IG5 Transcriptional regulator HGH94_03730 ENOG4105CBD Diacylglycerol kinase HGH94_03785 ENOG4105CDY transcriptional regulatory protein HGH94_03795 ENOG4105M4P Tetr family transcriptional regulator HGH94_03810 ENOG4105WEF catalase HGH94_03815 ENOG4105M18 -acetyltransferase HGH94_03830 ENOG4105C2F Histidine kinase HGH94_03835 ENOG4105EQD regulatoR HGH94_03840 ENOG410769Z extracellular solute-binding protein family 1 HGH94_03845 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component HGH94_03855 ENOG4105F5H Glycosyl Hydrolase Family 88 HGH94_03860 ENOG41075H3 AraC family transcriptional regulator HGH94_03865 ENOG4107TDE lipolytic protein G-D-S-L family HGH94_03880 ENOG4105CX8 fg-gap repeat protein HGH94_03885 ENOG4105CX8 fg-gap repeat protein HGH94_03900 ENOG4105EKC HGH94_03905 ENOG4105E0S extracellular solute-binding protein family 1 HGH94_03915 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HGH94_03920 ENOG4105F8D glycoside hydrolase family 4 HGH94_03925 ENOG4105H67 Protein of unknown function (DUF421) HGH94_03930 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) HGH94_03955 ENOG4106I4J membrane HGH94_03960 ENOG41061H0 Monooxygenase HGH94_03975 ENOG4108R1P HGH94_03980 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HGH94_03985 ENOG4105E0M Sulfatase HGH94_03990 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase HGH94_04000 ENOG41090R9 glycosyltransferase HGH94_04005 ENOG4107R51 Glycosyl transferase, family 2 HGH94_04010 ENOG41090R9 glycosyltransferase HGH94_04015 ENOG4105EU0 Major facilitator Superfamily HGH94_04025 ENOG4105CUB amino acid HGH94_04035 ENOG4105FKZ Methyl-accepting chemotaxis HGH94_04040 ENOG4105C5H ABC transporter HGH94_04050 ENOG4107SWG transcriptional regulator MERR family HGH94_04055 ENOG4105DXB Major Facilitator superfamily HGH94_04065 ENOG4105C5H ABC transporter HGH94_04070 ENOG4105FDU atp-dependent rna helicase HGH94_04085 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HGH94_04090 ENOG4105E0A ABC, transporter HGH94_04095 ENOG4108U1V ABC transporter, permease HGH94_04100 ENOG4105DQ5 transport system permease protein HGH94_04120 ENOG4108J20 pectate lyase HGH94_04125 ENOG4107QPK )-transporter HGH94_04135 ENOG4108MRH transcriptional regulatory protein HGH94_04160 ENOG410855V Acylphosphatase HGH94_04165 ENOG4108RPX mosc domain containing protein HGH94_04185 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) HGH94_04220 ENOG4105C5Y PTS System HGH94_04230 ENOG4107414 GntR family transcriptional regulator HGH94_04235 ENOG4108RCM Nitroreductase HGH94_04240 ENOG4105CGH 5'-nucleotidase HGH94_04245 ENOG4107RKG DJ-1/PfpI family HGH94_04260 ENOG4105KJF protein tyrosine phosphatase HGH94_04270 ENOG4107U9T Pfam:Ribonuclease_BN HGH94_04275 ENOG4108ISG Major Facilitator HGH94_04280 ENOG4105UPD Calcium Proton HGH94_04290 ENOG4105D8X mechanosensitive ion channel HGH94_04310 ENOG4106KE4 Dehydrogenase HGH94_04315 ENOG4105D7N magnesium and cobalt transport protein CorA HGH94_04325 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HGH94_04350 ENOG4107RUY (E1 component), alpha subunit HGH94_04360 ENOG4107QKR Dehydrogenase HGH94_04370 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HGH94_04375 ENOG41069DP small acid-soluble spore protein HGH94_04380 ENOG4105KK4 UPF0060 membrane protein HGH94_04410 ENOG4108Q3X Transcriptional regulator HGH94_04415 ENOG4105CI1 PTS System HGH94_04420 ENOG4105BZ1 (ABC) transporter HGH94_04425 ENOG4105BZ1 (ABC) transporter HGH94_04435 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase HGH94_04440 ENOG4105ID8 Transcriptional regulator, ARAC family HGH94_04445 ENOG4107QNK )-transporter HGH94_04450 ENOG4107QP6 Xylose isomerase domain protein TIM barrel HGH94_04455 ENOG4105CIB oxidoreductase Domain protein HGH94_04460 ENOG4105BZU Histidine kinase HGH94_04465 ENOG4105WH1 Two component transcriptional regulator luxr family HGH94_04470 ENOG4105CJ1 ABC, transporter HGH94_04475 ENOG41090VJ ABC-2 type transporter HGH94_04480 ENOG4108KYE ABC-2 type transporter HGH94_04490 ENOG4105U3E Transcriptional regulator HGH94_04495 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold HGH94_04505 ENOG4108YYS metal-dependent hydrolase (By similarity) HGH94_04510 ENOG4105C0R drug resistance transporter emrb qaca subfamily HGH94_04515 ENOG410834F Transcriptional regulator HGH94_04525 ENOG4108MES Periplasmic binding protein HGH94_04530 ENOG4105DQ5 transport system permease protein HGH94_04535 ENOG4108IHU transport system permease protein HGH94_04540 ENOG4105JAB phenazine biosynthesis protein, phzf family HGH94_04545 ENOG4107Y03 Nitroreductase HGH94_04560 ENOG4105ECP epimerase HGH94_04575 ENOG4105F27 Major Facilitator HGH94_04600 ENOG4106AKJ HGH94_04605 ENOG4105D74 hydrolase HGH94_04610 ENOG4105CKK Glycosyl transferase, family 2 HGH94_04615 ENOG4105EJV Membrane HGH94_04620 ENOG41067AE Membrane-bound metal-dependent hydrolase HGH94_04625 ENOG4105CEN a g-specific adenine glycosylase HGH94_04630 ENOG4106BXE HGH94_04635 ENOG4105CAN Short-chain dehydrogenase reductase Sdr HGH94_04650 ENOG4105EVI UPF0374 protein HGH94_04670 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HGH94_04675 ENOG4105G5W regulator Fur family HGH94_04805 ENOG4105EC3 peptidase S51, dipeptidase E HGH94_04810 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HGH94_04815 ENOG4105DNP FAD linked oxidase domain protein HGH94_04830 ENOG4105E2Y ABC, transporter HGH94_04835 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein HGH94_04845 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) HGH94_04855 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) HGH94_04860 ENOG4107D63 HGH94_04865 ENOG4105VZ8 Transcriptional regulator HGH94_04880 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HGH94_04890 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HGH94_04905 ENOG4105CYN Serine protein kinase HGH94_04910 ENOG4106AKX UPF0229 protein HGH94_04915 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HGH94_04920 ENOG4105CW7 secretion protein, HlyD family HGH94_04925 ENOG4105C0R drug resistance transporter emrb qaca subfamily HGH94_04930 ENOG4105CS1 NAD(P)H quinone oxidoreductase HGH94_04950 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family HGH94_04955 ENOG4105CZV ABC transporter HGH94_04960 ENOG4105CJ1 ABC, transporter HGH94_04965 ENOG4108TU7 Inherit from COG: (ABC) transporter HGH94_04970 ENOG4105VEQ Cold shock protein HGH94_04980 ENOG4105BZU Histidine kinase HGH94_05020 ENOG4108YBP pseudouridine synthase HGH94_05030 ENOG41080XP Cbs domain HGH94_05035 ENOG4107YBY Hydrolase HGH94_05040 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HGH94_05045 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HGH94_05050 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HGH94_05060 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HGH94_05065 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HGH94_05075 ENOG4105BZU Histidine kinase HGH94_05080 ENOG4105WH1 Two component transcriptional regulator luxr family HGH94_05115 ENOG4105ED1 spovr family HGH94_05120 ENOG4105G6Z alkaline phosphatase HGH94_05140 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HGH94_05145 ENOG4105CUB amino acid HGH94_05150 ENOG4105C8J )-transporter HGH94_05155 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HGH94_05170 ENOG4105J37 HGH94_05175 ENOG4108AEY RNA polymerase sigma factor HGH94_05180 ENOG4108FN7 Aldo keto reductase HGH94_05185 ENOG4105F6E Acyl-transferase HGH94_05190 ENOG4105C37 (CBS) domain HGH94_05205 ENOG4105C37 (CBS) domain HGH94_05215 ENOG4105WMR Protein CrcB homolog HGH94_05220 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HGH94_05230 ENOG4105D64 Mechanosensitive ion channel HGH94_05235 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HGH94_05240 ENOG4107VMI polysaccharide deacetylase HGH94_05245 ENOG4105F0I Aminotransferase HGH94_05265 ENOG4105BZ1 (ABC) transporter HGH94_05270 ENOG4105BZ1 (ABC) transporter HGH94_05295 ENOG410839P HGH94_05305 ENOG4106MP8 UPF0754 membrane protein HGH94_05310 ENOG4105WZB UPF0342 protein HGH94_05325 ENOG4105D4P Coproporphyrinogen iii oxidase HGH94_05330 ENOG4107S91 Sodium hydrogen exchanger HGH94_05335 ENOG4105NCW Trka-c domain protein HGH94_05345 ENOG4105CGU Enoyl-CoA hydratase HGH94_05355 ENOG4108IUX (ABC) transporter HGH94_05365 ENOG4107VRP DNA repair exonuclease HGH94_05370 ENOG4106D4I domain protein HGH94_05375 ENOG4105EQI Metal Dependent Phosphohydrolase HGH94_05385 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) HGH94_05430 ENOG4105NBU tryptophan transport protein HGH94_05440 ENOG4105K59 histidine triad (HIT) protein HGH94_05475 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation HGH94_05485 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) HGH94_05490 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HGH94_05495 ENOG4105C1Q protoporphyrinogen oxidase HGH94_05515 ENOG41090T1 Membrane HGH94_05525 ENOG4105DER m42 family HGH94_05540 ENOG4106AXD HGH94_05545 ENOG4108RQ5 Beta-lactamase domain-containing protein HGH94_05550 ENOG4105DF9 Lipoate-protein, ligase HGH94_05560 ENOG4105CEY Amp-dependent synthetase and ligase HGH94_05570 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 HGH94_05575 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HGH94_05580 ENOG4105KD7 acetyltransferase HGH94_05590 ENOG4108HUF Transporter HGH94_05595 ENOG4107TB6 phosphoglycerate mutase HGH94_05605 ENOG4107F3J Amp-dependent synthetase and ligase HGH94_05610 ENOG4107ZYJ bioY protein HGH94_05615 ENOG4106YBV Methyl-accepting chemotaxis HGH94_05635 ENOG4105XVF Competence transcription factor HGH94_05640 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HGH94_05645 ENOG4105X3H Excalibur domain protein HGH94_05650 ENOG4105E1V na solute symporter HGH94_05655 ENOG4106CAD Protein of unknown function (DUF3311) HGH94_05675 ENOG4107SCK Monooxygenase HGH94_05680 ENOG4108INS Transcriptional regulator HGH94_05695 ENOG4105TRI Hydrolase HGH94_05710 ENOG4108KK1 membrane protein AbrB duplication HGH94_05715 ENOG4106K7D Major facilitator family transporter HGH94_05720 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HGH94_05725 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding HGH94_05750 ENOG4105EYH Exonuclease HGH94_05800 ENOG4105ERH Fumarylacetoacetate hydrolase HGH94_05820 ENOG4105CAQ asparagine synthetase HGH94_05830 ENOG4105UQX Mate efflux family protein HGH94_05835 ENOG4106HBX Transcriptional Regulator AraC Family HGH94_05840 ENOG4105ETE Transcriptional regulator (LacI family HGH94_05845 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HGH94_05850 ENOG4105SF0 DinB family HGH94_05855 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HGH94_05860 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HGH94_05865 ENOG4105MYW Pentapeptide repeat protein HGH94_05870 ENOG4107S9D Alpha beta hydrolase HGH94_05875 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HGH94_05895 ENOG41061P3 phosphosulfolactate synthase HGH94_05905 ENOG4105DIA mandelate racemase muconate lactonizing HGH94_05955 ENOG41090VF Stage v sporulation protein ac HGH94_05960 ENOG4105CZ3 stage V sporulation protein ad HGH94_05985 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HGH94_05990 ENOG4105H67 Protein of unknown function (DUF421) HGH94_06000 ENOG4108SZE gCN5-related N-acetyltransferase HGH94_06005 ENOG4105MA6 gCN5-related N-acetyltransferase HGH94_06015 ENOG4108VPT UPF0234 protein HGH94_06020 ENOG4105QNR S1 RNA binding domain protein HGH94_06040 ENOG4105K7K Transcriptional regulator HGH94_06050 ENOG410751J HGH94_06060 ENOG4105EPR degv family HGH94_06065 ENOG4107AYK membrAne HGH94_06075 ENOG41073B9 HGH94_06085 ENOG4108KP7 hydrolase HGH94_06090 ENOG4108MXZ Esterase HGH94_06095 ENOG4105VG1 fes assembly suf system protein HGH94_06105 ENOG4105IQ5 FAD linked oxidase domain protein HGH94_06115 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HGH94_06120 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) HGH94_06130 ENOG4105C8Y Acetylornithine aminotransferase HGH94_06135 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HGH94_06145 ENOG4105DBV ornithine carbamoyltransferase HGH94_06170 ENOG4107RMD Basic membrane lipoprotein HGH94_06185 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HGH94_06190 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HGH94_06200 ENOG4105C3U ABC transporter HGH94_06220 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HGH94_06230 ENOG4105C31 Tryptophanyl-tRNA synthetase HGH94_06235 ENOG4108J59 Extracellular solute-binding protein, family 5 HGH94_06240 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HGH94_06245 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HGH94_06255 ENOG4108JQ7 (ABC) transporter HGH94_06270 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) HGH94_06275 ENOG4108ZCF integral membrane protein HGH94_06285 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis HGH94_06300 ENOG4105DPN Oligoendopeptidase f HGH94_06310 ENOG4105T58 Dithiol-disulfide isomerase HGH94_06315 ENOG4108Z18 K06886 hemoglobin HGH94_06320 ENOG4105E4C Lytic transglycosylase catalytic HGH94_06325 ENOG4105MIX Adenylate cyclase HGH94_06340 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HGH94_06345 ENOG4105EMS pseudouridine synthase HGH94_06360 ENOG4105ETU transcriptional activator (TenA HGH94_06365 ENOG4108VEU Thiamine monophosphate synthase HGH94_06380 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HGH94_06385 ENOG4105D06 uba thif-type nad fad binding protein HGH94_06390 ENOG4105DWF phosphomethylpyrimidine kinase HGH94_06395 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HGH94_06450 ENOG4105ENA helicase HGH94_06465 ENOG4108ZMI UPF0477 protein HGH94_06475 ENOG4105C28 cystathionine HGH94_06480 ENOG4105C28 cystathionine HGH94_06485 ENOG4105D9U N-acetyltransferase HGH94_06490 ENOG4105JHY Membrane HGH94_06515 ENOG4106BHF HGH94_06570 ENOG4108PSK reductase HGH94_06585 ENOG4105DM4 PTS System HGH94_06590 ENOG4105DG6 mannose-6-phosphate isomerase HGH94_06595 ENOG4105G7B Protein of unknown function (DUF2992) HGH94_06605 ENOG4105VMI -acetyltransferase HGH94_06615 ENOG4108Z66 YbaK ebsC protein HGH94_06630 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HGH94_06640 ENOG4108ZJ4 polysaccharide deacetylase HGH94_06645 ENOG4105DQ6 Transposase HGH94_06660 ENOG4107CUJ Protein of unknown function (DUF2690) HGH94_06710 ENOG4106A3M Cytochrome p-450 HGH94_06715 ENOG41087PP glycosyltransferase MGT family HGH94_06725 ENOG4105EXQ uroporphyrinogen iii synthase hem4 HGH94_06730 ENOG4105C4B ABC transporter, permease HGH94_06735 ENOG4108IXI (ABC) transporter HGH94_06745 ENOG4105Q95 Cupin 2, conserved barrel domain protein HGH94_06760 ENOG4105D2H Uronic isomerase HGH94_06770 ENOG4105DG4 malate L-lactate dehydrogenase HGH94_06775 ENOG4105CPQ Dehydrogenase HGH94_06780 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) HGH94_06785 ENOG4105DMW Dehydrogenase reductase HGH94_06790 ENOG4108I5G Major Facilitator superfamily HGH94_06795 ENOG4107KJX Transcriptional regulator HGH94_06800 ENOG4107QZW Altronate oxidoreductase HGH94_06810 ENOG4107TSN permease HGH94_06820 ENOG4105JD4 ATPase yjob HGH94_06835 ENOG41068K0 YCII-related domain HGH94_06840 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase HGH94_06845 ENOG4105KWG Pfam:DUF1696 HGH94_06850 ENOG4105K7W phage-related replication protein HGH94_06855 ENOG4105WEF catalase HGH94_06860 ENOG410635T phage-like element pbsx protein HGH94_06905 ENOG4108TFU terminase (Small subunit) HGH94_06910 ENOG4105IG6 Phage terminase, large subunit HGH94_06915 ENOG4108MDF Phage Portal Protein HGH94_06940 ENOG41060SN HGH94_06955 ENOG4105PQS phage protein HGH94_06960 ENOG4105FR7 XkdM protein, phage-like element PBSX HGH94_06980 ENOG4108WZM domain protein HGH94_06985 ENOG4105X7F HGH94_06995 ENOG4105MFU Protein of unknown function (DUF2634) HGH94_07000 ENOG41066EA baseplate J family protein HGH94_07005 ENOG410906S phage-like element pbsx protein xkdt HGH94_07015 ENOG41068G1 HGH94_07040 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HGH94_07065 ENOG4107GRR phosphate transport regulator HGH94_07070 ENOG4107R7I amino acid HGH94_07080 ENOG4105EDW glycosyl transferase, family 39 HGH94_07085 ENOG4105CKK Glycosyl transferase, family 2 HGH94_07095 ENOG4105C0H protease HGH94_07105 ENOG4108ME1 Peptidase M55 D-aminopeptidase HGH94_07110 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HGH94_07115 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HGH94_07120 ENOG4105C3U ABC transporter HGH94_07130 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HGH94_07135 ENOG4105DTQ mandelate racemase muconate lactonizing HGH94_07145 ENOG4108JQ7 (ABC) transporter HGH94_07150 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) HGH94_07155 ENOG4107TUM Amidinotransferase HGH94_07160 ENOG4108S4H thioesterase Superfamily protein HGH94_07165 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HGH94_07185 ENOG4108428 Inherit from COG: -acetyltransferase HGH94_07195 ENOG41080TC multidrug resistance protein HGH94_07200 ENOG4105CIY formyltetrahydrofolate deformylase HGH94_07205 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HGH94_07220 ENOG4105K56 Transcriptional regulator HGH94_07225 ENOG4108ZHJ Organic hydroperoxide resistance protein HGH94_07230 ENOG4107Y2X deaminase HGH94_07240 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HGH94_07245 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HGH94_07255 ENOG4108W7F transporter, permease HGH94_07260 ENOG4108JJB ABC transporter HGH94_07265 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein HGH94_07270 ENOG4108X43 YKOF domain protein HGH94_07275 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HGH94_07280 ENOG41062D9 Histidine kinase HGH94_07290 ENOG4106849 propeptide, pepSY amd peptidase M4 HGH94_07300 ENOG4105CJW magnesium transporter HGH94_07305 ENOG4105V75 Transcriptional regulator HGH94_07350 ENOG4105DQE DNA ligase HGH94_07355 ENOG4105FDF Could be involved in DNA repair (By similarity) HGH94_07365 ENOG4107T5V SNARE associated Golgi HGH94_07370 ENOG4107TS3 membrane protein, TerC HGH94_07375 ENOG4108WZW RNA polymerase sigma HGH94_07385 ENOG410681C small acid-soluble spore protein HGH94_07395 ENOG4105D0M Protease HtpX homolog HGH94_07425 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HGH94_07435 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) HGH94_07440 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HGH94_07445 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HGH94_07455 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit HGH94_07460 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) HGH94_07465 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) HGH94_07490 ENOG4105BZU Histidine kinase HGH94_07495 ENOG41090MY MarR family Transcriptional regulator HGH94_07500 ENOG4105ER2 Ompa motb domain protein HGH94_07505 ENOG4105E14 MotA TolQ exbB proton channel HGH94_07515 ENOG4108K88 Membrane HGH94_07520 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HGH94_07525 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase HGH94_07530 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HGH94_07535 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HGH94_07600 ENOG4105VTR Integrase HGH94_07625 ENOG4105F0V Cell wall hydrolase HGH94_07650 ENOG4105DC7 peptidase M24 HGH94_07660 ENOG4105CID antiterminator HGH94_07670 ENOG4105KRI phosphocarrier protein (HPr HGH94_07675 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HGH94_07685 ENOG4105F6S Spore photoproduct lyase HGH94_07695 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer HGH94_07700 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HGH94_07710 ENOG4105K4I Scp-like extracellular HGH94_07720 ENOG4105BZU Histidine kinase HGH94_07725 ENOG4105CHM Aminotransferase HGH94_07735 ENOG4107R88 Chemotaxis protein (CheV) HGH94_07740 ENOG4105UIN HGH94_07750 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein HGH94_07765 ENOG4105ESF Peptidoglycan binding domain protein HGH94_07775 ENOG4105EPM Diguanylate phosphodiesterase HGH94_07780 ENOG4107IN1 Protein of unknown function (DUF1797) HGH94_07785 ENOG4108XRC Protein of unknown function (DUF458) HGH94_07815 ENOG4105NQC Flavodoxin HGH94_07825 ENOG4105CH2 amidohydrolase HGH94_07840 ENOG4105D3R alkyl hydroperoxide reductase HGH94_07845 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HGH94_07865 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HGH94_07870 ENOG4105D06 uba thif-type nad fad binding protein HGH94_07875 ENOG4105CVM Molybdenum cofactor synthesis domain protein HGH94_07880 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein HGH94_07885 ENOG4108ZAF Molybdopterin HGH94_07890 ENOG41067WU Molybdopterin converting factor (Subunit 1) HGH94_07895 ENOG4105BZ1 (ABC) transporter HGH94_07900 ENOG4105BZ1 (ABC) transporter HGH94_07910 ENOG4107X8C Efflux transporter RND family MFP subunit HGH94_07915 ENOG4105C19 ABC transporter HGH94_07920 ENOG4107RBB ABC transporter, permease HGH94_07925 ENOG4105E98 transcriptional regulator DeoR family HGH94_07930 ENOG4105DE4 1-phosphofructokinase HGH94_07935 ENOG4105DM4 PTS System HGH94_07940 ENOG4105C3F Signal peptidase i HGH94_07955 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HGH94_07980 ENOG4105BZU Histidine kinase HGH94_07990 ENOG4107ZYR domain protein HGH94_08000 ENOG4105CN5 Metallo-Beta-Lactamase HGH94_08010 ENOG4108X4Q Hydrolase HGH94_08015 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HGH94_08035 ENOG4105CPP Dehydrogenase, E1 component HGH94_08040 ENOG4105C7S Dehydrogenase HGH94_08045 ENOG4107QN2 dihydrolipoyl dehydrogenase HGH94_08060 ENOG4105CXN decarboxylase HGH94_08065 ENOG4105WBI UPF0223 protein HGH94_08080 ENOG4105ECY inositol monophosphatase HGH94_08090 ENOG4105JQZ Methyltransferase HGH94_08135 ENOG4105CI3 gtp-binding protein typa HGH94_08140 ENOG4105QA2 HGH94_08155 ENOG4108IAB Phoh family HGH94_08165 ENOG4105CSV Glutaminase HGH94_08170 ENOG4105ZPI UPF0358 protein HGH94_08175 ENOG4105CNI cell division protein FtsW HGH94_08180 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) HGH94_08190 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) HGH94_08200 ENOG4105BZ9 Cytochrome C oxidase, subunit I HGH94_08205 ENOG4105CCU oxidase (Subunit III) HGH94_08210 ENOG41064X9 cytochrome C oxidase subunit IV HGH94_08225 ENOG41080XQ Signal transduction protein with cbs domains HGH94_08230 ENOG4106UY4 Inherit from COG: Scp-like extracellular HGH94_08250 ENOG4105WUC UPF0298 protein HGH94_08255 ENOG4106H78 methyltransferase HGH94_08260 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) HGH94_08270 ENOG4105D78 K07001 NTE family protein HGH94_08275 ENOG41063PX domain protein HGH94_08280 ENOG4105CDE UPF0348 protein HGH94_08290 ENOG4105KNH Nucleic acid-binding protein HGH94_08320 ENOG4108V6E Cell division protein mraZ HGH94_08325 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) HGH94_08340 ENOG4105CJN penicillin-binding protein HGH94_08345 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HGH94_08350 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) HGH94_08355 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HGH94_08360 ENOG4105CNI cell division protein FtsW HGH94_08365 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HGH94_08370 ENOG4105D4A Cell wall formation (By similarity) HGH94_08375 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) HGH94_08380 ENOG4108R2U division initiation protein HGH94_08390 ENOG4105K67 small basic protein HGH94_08395 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HGH94_08400 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HGH94_08410 ENOG4105FFI sigma-e processing peptidase spoiiga HGH94_08415 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HGH94_08435 ENOG4105WR5 sporulation protein, YlmC YmxH family HGH94_08440 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HGH94_08445 ENOG4105DFA alanine racemase domain protein HGH94_08450 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) HGH94_08455 ENOG41067XK integral membrane protein HGH94_08460 ENOG4105DBK s4 domain protein HGH94_08470 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HGH94_08480 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) HGH94_08485 ENOG4105C34 Pseudouridine synthase HGH94_08490 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) HGH94_08500 ENOG4105CXT aspartate transcarbamylase HGH94_08510 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HGH94_08515 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HGH94_08520 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) HGH94_08525 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) HGH94_08530 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HGH94_08535 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) HGH94_08550 ENOG4107S4M Sulfate adenylate transferase HGH94_08555 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) HGH94_08560 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) HGH94_08565 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein HGH94_08570 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein HGH94_08585 ENOG4105DSJ YicC domain protein HGH94_08590 ENOG4105KC4 UPF0296 protein HGH94_08595 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HGH94_08605 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HGH94_08615 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) HGH94_08620 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) HGH94_08625 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HGH94_08630 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs HGH94_08635 ENOG4108ZF3 Phosphatase HGH94_08640 ENOG4105D9P serine threonine protein kinase HGH94_08645 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HGH94_08650 ENOG4105DJV ribulose-phosphate 3-epimerase HGH94_08655 ENOG4105FJ0 thiamine HGH94_08665 ENOG4105VB9 50S ribosomal protein l28 HGH94_08670 ENOG4108ZAA Alkaline-shock protein HGH94_08675 ENOG4105DP4 dak2 domain fusion protein ylov HGH94_08685 ENOG4105EJQ L-serine dehydratase HGH94_08690 ENOG4105CB5 ATP-dependent DNA helicase recG HGH94_08695 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) HGH94_08705 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HGH94_08720 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) HGH94_08725 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) HGH94_08730 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HGH94_08740 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) HGH94_08750 ENOG4105K5M 30s ribosomal protein S16 HGH94_08755 ENOG4108BW8 UPF0109 protein HGH94_08765 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) HGH94_08770 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) HGH94_08775 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) HGH94_08780 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) HGH94_08785 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HGH94_08795 ENOG4105VM1 flagellar HGH94_08800 ENOG4105CMV Succinyl-CoA synthetase subunit beta HGH94_08805 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HGH94_08810 ENOG4105C79 DNA protecting protein DprA HGH94_08815 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HGH94_08820 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) HGH94_08825 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HGH94_08830 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) HGH94_08835 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) HGH94_08845 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HGH94_08855 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HGH94_08860 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HGH94_08865 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HGH94_08880 ENOG4106YF4 Flagellar biosynthesis chaperone HGH94_08890 ENOG410696Y Flagellar hook-length control protein HGH94_08895 ENOG410822I Flagellar hook capping protein HGH94_08900 ENOG4108JQA flagellar HGH94_08905 ENOG41068WV flagellar FlbD family protein HGH94_08915 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HGH94_08920 ENOG4105DD5 Flagellar motor switch protein HGH94_08925 ENOG4107YTP response regulator receiver protein HGH94_08935 ENOG4105CN7 Flagellar biosynthetic protein FliP HGH94_08940 ENOG4105VS8 Flagellar biosynthetic protein fliq HGH94_08950 ENOG4105D00 flagellar biosynthetic protein flhB HGH94_08955 ENOG4105D7B Flagellar biosynthesis protein flha HGH94_08960 ENOG4105FZW flagellar biosynthesis regulator FlhF HGH94_08970 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HGH94_08980 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis HGH94_08995 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HGH94_09005 ENOG4105CE9 30S ribosomal protein S2 HGH94_09020 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) HGH94_09025 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HGH94_09030 ENOG4105KNE Phosphatidate cytidylyltransferase HGH94_09040 ENOG4105DZP Membrane-associated zinc metalloprotease HGH94_09045 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) HGH94_09055 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) HGH94_09060 ENOG4105CHV Transcription elongation factor NusA HGH94_09065 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination HGH94_09070 ENOG4105VHM ribosomal protein HGH94_09075 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) HGH94_09080 ENOG4105W7A Protein of unknown function (DUF503) HGH94_09085 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) HGH94_09090 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) HGH94_09095 ENOG4105DTN riboflavin biosynthesis protein ribF HGH94_09100 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) HGH94_09105 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) HGH94_09115 ENOG4105C1V Peptidase, M16 HGH94_09125 ENOG4105E35 Dipicolinate synthase subunit A HGH94_09130 ENOG4108S0H Dipicolinic acid synthetase, b subunit HGH94_09135 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HGH94_09145 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HGH94_09155 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit HGH94_09165 ENOG4105CNU cell division protein FtsK HGH94_09170 ENOG4105FDP GntR family transcriptional regulator HGH94_09190 ENOG4108RKS Short-chain dehydrogenase reductase Sdr HGH94_09195 ENOG4105XZV Protein of unknown function (DUF3243) HGH94_09210 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase HGH94_09225 ENOG4108A04 Beta-lactamase HGH94_09230 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) HGH94_09235 ENOG4105D48 metallophosphoesterase HGH94_09240 ENOG4105MCT stage V sporulation protein S HGH94_09250 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HGH94_09270 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HGH94_09285 ENOG4105IIP Membrane HGH94_09305 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin HGH94_09315 ENOG4105K7W phage-related replication protein HGH94_09320 ENOG4108X3M OsmC Ohr family protein HGH94_09325 ENOG410814C multidrug resistance protein HGH94_09350 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) HGH94_09365 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HGH94_09370 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HGH94_09375 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HGH94_09380 ENOG4105U6W MutT NUDIX family protein HGH94_09390 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HGH94_09395 ENOG4106F1P AAA ATPase, central domain protein HGH94_09400 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HGH94_09405 ENOG4105CXI aluminum resistance protein HGH94_09410 ENOG4105KV4 Transcriptional regulator HGH94_09415 ENOG4105C5F glutamine synthetase HGH94_09450 ENOG410907G HGH94_09460 ENOG4105CT4 transporter HGH94_09465 ENOG4105DSG hydrolase family 43 HGH94_09470 ENOG4105E2R ROK family HGH94_09475 ENOG4105C93 Xylose Isomerase HGH94_09480 ENOG4105CMG Carbohydrate kinase HGH94_09505 ENOG4107Y9E nuclease HGH94_09510 ENOG4105C54 Major Facilitator superfamily HGH94_09515 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HGH94_09525 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HGH94_09600 ENOG4108Q8B Spore germination protein HGH94_09620 ENOG4105FVX HGH94_09630 ENOG4105K7W phage-related replication protein HGH94_09640 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) HGH94_09645 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HGH94_09655 ENOG4108SVB resolvase HGH94_09660 ENOG4105VPS UPF0291 protein HGH94_09665 ENOG4105CV1 Transketolase (EC 2.2.1.1) HGH94_09685 ENOG4107QIV Cytochrome c biogenesis protein HGH94_09710 ENOG4107DZX Small, acid-soluble spore protein P HGH94_09720 ENOG4108I0Z Aconitate hydratase HGH94_09725 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HGH94_09740 ENOG41067CD Small, acid-soluble spore protein Tlp HGH94_09750 ENOG4105MI2 HGH94_09755 ENOG4105W8X HesB YadR YfhF-family protein HGH94_09760 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) HGH94_09765 ENOG4105K4P CoA-binding domain protein HGH94_09770 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HGH94_09790 ENOG4107QWR cellulase (EC 3.2.1.4) HGH94_09805 ENOG4107SYN Glycosyl hydrolases family 43 HGH94_09815 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HGH94_09820 ENOG4107T5V SNARE associated Golgi HGH94_09830 ENOG4107QX3 carboxylase HGH94_09835 ENOG4105E39 Enoyl-CoA hydratase HGH94_09840 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase HGH94_09845 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HGH94_09850 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HGH94_09855 ENOG4105CEY Amp-dependent synthetase and ligase HGH94_09860 ENOG4105C1G acyl-Coa dehydrogenase HGH94_09875 ENOG4105F32 YngK protein HGH94_09880 ENOG4106U2H Protein of unknown function (DUF1360) HGH94_09895 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family HGH94_09900 ENOG4108N2V aldose 1-epimerase HGH94_09905 ENOG4107QJQ Mate efflux family protein HGH94_09930 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HGH94_09935 ENOG4105SKE transcriptional Regulator LysR family HGH94_09950 ENOG4105CBC glutamate synthase HGH94_09955 ENOG4105C5Q Transcriptional regulator HGH94_09960 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) HGH94_09965 ENOG4105II7 pyrroline-5-carboxylate reductase HGH94_09990 ENOG41068WN HGH94_10005 ENOG4105CJ1 ABC, transporter HGH94_10015 ENOG4105IE8 Alpha-ketoglutarate permease HGH94_10020 ENOG4107U6E carbohydrate kinase FGGY HGH94_10025 ENOG4108M3J Dehydrogenase HGH94_10070 ENOG4108YQE rare lipoprotein a HGH94_10075 ENOG4105XPP Protein of unknown function (DUF1275) HGH94_10080 ENOG4108NR7 pectate lyase HGH94_10085 ENOG4108RAV Conserved protein HGH94_10125 ENOG41073R8 VanW family HGH94_10150 ENOG4108Q5Y Membrane HGH94_10170 ENOG4108V4B ThiJ pfpI HGH94_10180 ENOG41090AA HGH94_10185 ENOG4106BHF HGH94_10205 ENOG4108Z7R Chaperone CsaA HGH94_10215 ENOG4108HJF gCN5-related N-acetyltransferase HGH94_10225 ENOG4108W8B Beta-lactamase domain protein HGH94_10235 ENOG4105D29 Helix-turn-helix type 11 domain protein HGH94_10245 ENOG4105KTU Transcriptional regulator, arsr family HGH94_10260 ENOG4108SJC Membrane HGH94_10280 ENOG4105ECK Fatty Acid Desaturase HGH94_10285 ENOG4108ZGX Histidine kinase HGH94_10290 ENOG4108S01 response regulator HGH94_10295 ENOG41069ER domain protein HGH94_10300 ENOG4105C9U ATP-dependent DNA helicase RecQ HGH94_10310 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HGH94_10315 ENOG4105SCY DNAK suppressor HGH94_10355 ENOG4105C26 Dehydrogenase HGH94_10360 ENOG4105EWU Squalene--hopene cyclase HGH94_10365 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HGH94_10370 ENOG4105C8J )-transporter HGH94_10380 ENOG4105C7S Dehydrogenase HGH94_10390 ENOG4107T89 von Willebrand factor, type A HGH94_10395 ENOG4105GMT ATPase associated with various cellular activities aaa_5 HGH94_10405 ENOG4105K4H Nlp p60 protein HGH94_10425 ENOG4106SCS STAS domain HGH94_10460 ENOG4105C6Z Gluconate HGH94_10465 ENOG41090U3 tautomerase HGH94_10485 ENOG4105FBA Phospholipase Carboxylesterase HGH94_10500 ENOG4105E1V na solute symporter HGH94_10525 ENOG4108VXD carboxy-peptidase HGH94_10530 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HGH94_10540 ENOG4106Z5R HGH94_10545 ENOG410841Q phosphoesterase PA-phosphatase related protein HGH94_10575 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HGH94_10580 ENOG4108TSC N-acetyltransferase HGH94_10585 ENOG4107S4Y M20 DapE family protein YgeY HGH94_10600 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HGH94_10640 ENOG4107T32 3-phytase (EC 3.1.3.8) HGH94_10645 ENOG4105C5E polysaccharide biosynthesis protein HGH94_10655 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) HGH94_10705 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HGH94_10735 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HGH94_10760 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HGH94_10770 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HGH94_10775 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) HGH94_10900 ENOG4105C2M dna polymerase I HGH94_10970 ENOG4108J9Q DNA ligase HGH94_11005 ENOG4105GJD protein, conserved in bacteria HGH94_11095 ENOG4107D0N HGH94_11150 ENOG4106J6E HGH94_11225 ENOG4108NE4 HGH94_11250 ENOG4105ZUG HGH94_11260 ENOG4105ZUG HGH94_11265 ENOG4105K70 DNA-binding protein HGH94_11385 ENOG41068G1 HGH94_11400 ENOG4107VXM glycerophosphoryl diester phosphodiesterase HGH94_11430 ENOG4105E4C Lytic transglycosylase catalytic HGH94_11475 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HGH94_11495 ENOG4107R0E Glycosyl transferase, family 2 HGH94_11520 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HGH94_11550 ENOG4105UA4 acetyltransferase HGH94_11565 ENOG4106ANW SMI1_KNR4 HGH94_11570 ENOG4106BHF HGH94_11585 ENOG4107Y9E nuclease HGH94_11610 ENOG4105C5E polysaccharide biosynthesis protein HGH94_11615 ENOG4105E0X reductase HGH94_11620 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) HGH94_11640 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) HGH94_11645 ENOG41090WU lipolytic protein G-D-S-L family HGH94_11650 ENOG4108KF3 Electron transport protein SCO1 SenC HGH94_11670 ENOG4108UT2 hemolysin iii HGH94_11685 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HGH94_11700 ENOG4107YX5 Pfam:DUF548 HGH94_11705 ENOG4108Y6J UPF0403 protein HGH94_11710 ENOG4105C01 Dihydroxy-acid dehydratase HGH94_11725 ENOG4108V06 Glutathione peroxidase HGH94_11800 ENOG410890F Dynamin family HGH94_11815 ENOG41065KQ synthase HGH94_11820 ENOG4105C2W permease HGH94_11825 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) HGH94_11830 ENOG4105CTD carboxy-peptidase HGH94_11835 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) HGH94_11840 ENOG4108UHU Aldolase HGH94_11845 ENOG4105D7K pfkb domain protein HGH94_11860 ENOG4105CHR reductase HGH94_11865 ENOG4105DVT helicase HGH94_11895 ENOG4108UKS UPF0398 protein HGH94_11915 ENOG4108I5C dEAD DEAH box helicase HGH94_11965 ENOG4105BZ4 penicillin-binding protein HGH94_11975 ENOG4105CSM endonuclease III HGH94_11985 ENOG4105C5S asparaginyl-tRNA synthetase HGH94_11990 ENOG4105CHM Aminotransferase HGH94_12000 ENOG4105YAC HGH94_12005 ENOG4105DVT helicase HGH94_12010 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) HGH94_12015 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HGH94_12020 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HGH94_12025 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HGH94_12030 ENOG4105DJ0 Poly(A) Polymerase HGH94_12035 ENOG4105CPK Glycosyl transferase (Group 1 HGH94_12040 ENOG4105FJR Lmbe family HGH94_12045 ENOG4108Z5K methylglyoxal synthase HGH94_12050 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) HGH94_12055 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase HGH94_12060 ENOG4108JYZ YitT family HGH94_12080 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) HGH94_12100 ENOG41068YB TPR repeat-containing protein HGH94_12105 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase HGH94_12125 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) HGH94_12130 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase HGH94_12140 ENOG4108I0Q anthranilate phosphoribosyltransferase HGH94_12145 ENOG4105CRQ synthase (Component I) HGH94_12150 ENOG4105KHN chorismate mutase HGH94_12155 ENOG4105D49 3-dehydroquinate synthase HGH94_12160 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HGH94_12165 ENOG4105BZU Histidine kinase HGH94_12170 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) HGH94_12175 ENOG4105EAH synthase HGH94_12180 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) HGH94_12185 ENOG4105XXQ heptaprenyl diphosphate synthase component I HGH94_12195 ENOG4105EUJ GTP cyclohydrolase i HGH94_12200 ENOG4105K70 DNA-binding protein HGH94_12205 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) HGH94_12220 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase HGH94_12225 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) HGH94_12230 ENOG41065D1 HGH94_12235 ENOG4105S2F HGH94_12250 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HGH94_12255 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HGH94_12260 ENOG4105CAT Cytidine monophosphate kinase HGH94_12275 ENOG4105MSI germination protein ypeb HGH94_12285 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) HGH94_12290 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase HGH94_12305 ENOG4107RGJ metallophosphoesterase HGH94_12320 ENOG4105I7S Abortive infection protein HGH94_12325 ENOG4105C9U ATP-dependent DNA helicase RecQ HGH94_12330 ENOG4105T7X HGH94_12340 ENOG4108SAX Membrane HGH94_12345 ENOG4108JQ1 Dehydrogenase HGH94_12350 ENOG4105FF2 Type I DHQase HGH94_12365 ENOG4105BZU Histidine kinase HGH94_12370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HGH94_12375 ENOG4105CRE cytochrome C HGH94_12380 ENOG4107TWT Cytochrome c biogenesis protein HGH94_12390 ENOG4105FE9 pseudouridine synthase HGH94_12400 ENOG4108JIC nucleoside recognition domain protein HGH94_12405 ENOG4105DZ1 carboxypeptidase HGH94_12415 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) HGH94_12420 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) HGH94_12435 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HGH94_12440 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) HGH94_12445 ENOG4108R6K riboflavin synthase, subunit alpha HGH94_12450 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HGH94_12460 ENOG4105C3F Signal peptidase i HGH94_12470 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) HGH94_12490 ENOG4107ZE5 PPIases accelerate the folding of proteins HGH94_12495 ENOG4105PTM secreted protein HGH94_12510 ENOG4105G6R Stage v sporulation protein ae HGH94_12520 ENOG4105CZ3 stage V sporulation protein ad HGH94_12525 ENOG41090VF Stage v sporulation protein ac HGH94_12540 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HGH94_12545 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) HGH94_12550 ENOG41082AN stage II sporulation protein HGH94_12555 ENOG4105DZ1 carboxypeptidase HGH94_12560 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HGH94_12565 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HGH94_12570 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HGH94_12580 ENOG4105I3K Ferric uptake regulator, Fur family HGH94_12585 ENOG4105MZ9 stage II sporulation protein m HGH94_12600 ENOG4105DFD Na H antiporter HGH94_12605 ENOG4108IJ0 Aspartate ammonia-lyase HGH94_12615 ENOG4108IMY Transcriptional regulator HGH94_12625 ENOG4108YZ4 nudix hydrolase HGH94_12635 ENOG4105CPC Aldo Keto reductase HGH94_12655 ENOG4106HZJ HGH94_12660 ENOG4105RHY Pfam:UPF0157 HGH94_12665 ENOG4105KAC Antibiotic biosynthesis monooxygenase HGH94_12670 ENOG4108XET gCN5-related N-acetyltransferase HGH94_12680 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HGH94_12690 ENOG4105E5W Transporter HGH94_12700 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase HGH94_12715 ENOG4108IXY short-chain dehydrogenase reductase HGH94_12720 ENOG41069FQ Metallo-beta-lactamase superfamily HGH94_12725 ENOG4105II7 pyrroline-5-carboxylate reductase HGH94_12740 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HGH94_12755 ENOG410861F 50S ribosomal protein L33 HGH94_12760 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) HGH94_12770 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HGH94_12775 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HGH94_12785 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) HGH94_12790 ENOG4108NA0 Uncharacterized conserved protein (COG2071) HGH94_12805 ENOG4108HNZ carboxyl transferase HGH94_12810 ENOG4108ZVT methylmalonyl-coA epimerase HGH94_12820 ENOG4108VZI ErfK ybiS ycfS ynhG family protein HGH94_12825 ENOG4108QEG Membrane HGH94_12830 ENOG4105CDA abc transporter atp-binding protein HGH94_12835 ENOG4105E5Q amino acid AbC transporter HGH94_12840 ENOG4108HW3 (ABC) transporter HGH94_12845 ENOG4108Y6J UPF0403 protein HGH94_12850 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) HGH94_12865 ENOG4105C7S Dehydrogenase HGH94_12870 ENOG4105CPP Dehydrogenase, E1 component HGH94_12885 ENOG4105CKM Branched-chain carboxylic acid kinase HGH94_12890 ENOG4107RDP Dehydrogenase HGH94_12900 ENOG4108JUB Transcriptional regulator HGH94_12905 ENOG4106CCJ Protein of unknown function (DUF2627) HGH94_12910 ENOG4105CR4 methylisocitrate lyase HGH94_12915 ENOG4105DXD 2-methylcitrate dehydratase HGH94_12925 ENOG4105C1G acyl-Coa dehydrogenase HGH94_12930 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HGH94_12940 ENOG4108QXE glycerophosphoryl diester phosphodiesterase HGH94_12945 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HGH94_12960 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HGH94_12965 ENOG4107QQR Sporulation HGH94_12980 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HGH94_12985 ENOG4105DX0 Hemolysin A HGH94_12995 ENOG4105CTB Polyprenyl synthetase HGH94_13000 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HGH94_13005 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HGH94_13010 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HGH94_13015 ENOG4105M7K Involved in the transcription termination process (By similarity) HGH94_13020 ENOG4108ZSR alkaline shock protein HGH94_13025 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HGH94_13045 ENOG410644B Stage III sporulation protein af HGH94_13055 ENOG4105KQ4 Stage iii sporulation protein ad HGH94_13060 ENOG4108CQH stage III sporulation protein AC HGH94_13065 ENOG4105KR5 Stage iii sporulation protein HGH94_13070 ENOG4105CD2 stage iii sporulation protein aa HGH94_13080 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) HGH94_13090 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) HGH94_13100 ENOG4105CBJ Metal-dependent enzyme HGH94_13115 ENOG4105KST dependent repressor HGH94_13120 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) HGH94_13125 ENOG4105WZW rhodanese family HGH94_13130 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HGH94_13135 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HGH94_13140 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HGH94_13145 ENOG4105C0D helicase HGH94_13160 ENOG4108IMY Transcriptional regulator HGH94_13170 ENOG4105VFR signal peptidase HGH94_13235 ENOG4105C37 (CBS) domain HGH94_13260 ENOG4105C5X domain protein HGH94_13300 ENOG4107ZXI Rhomboid family HGH94_13310 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HGH94_13335 ENOG41068DG YceG-like family HGH94_13350 ENOG4105E2Z phosphate ABC transporter (Permease HGH94_13355 ENOG4105C8U phosphate abc transporter HGH94_13360 ENOG4105CVA phosphate HGH94_13365 ENOG4107RF6 penicillin-binding protein HGH94_13375 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HGH94_13380 ENOG4105SXS Protein of unknown function (DUF456) HGH94_13395 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) HGH94_13400 ENOG41063Y9 HGH94_13405 ENOG4108U5J '-nucleotidase HGH94_13415 ENOG4108JYZ YitT family HGH94_13425 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HGH94_13440 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) HGH94_13450 ENOG4105EGD dinuclear metal center protein, YbgI family HGH94_13465 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HGH94_13470 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HGH94_13480 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) HGH94_13490 ENOG4105C38 Glycyl-tRNA synthetase beta subunit HGH94_13495 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit HGH94_13500 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) HGH94_13510 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) HGH94_13515 ENOG4105KG3 cytidine deaminase HGH94_13520 ENOG4107YR5 Diacylglycerol kinase HGH94_13525 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) HGH94_13530 ENOG4105CTJ Metal Dependent Phosphohydrolase HGH94_13535 ENOG4105C9A Phoh family HGH94_13545 ENOG41068P3 sporulation protein YqfC HGH94_13555 ENOG4105DI5 UPF0365 protein HGH94_13560 ENOG4105F7J membrane-bound serine protease HGH94_13565 ENOG4105KTH gatB Yqey HGH94_13580 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) HGH94_13585 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HGH94_13590 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) HGH94_13600 ENOG4105CFG Acts as a chaperone (By similarity) HGH94_13605 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ HGH94_13610 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) HGH94_13615 ENOG4105CSA Coproporphyrinogen iii oxidase HGH94_13620 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) HGH94_13630 ENOG4108ZRV stage ii sporulation protein p HGH94_13635 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) HGH94_13640 ENOG41082YS Binds directly to 16S ribosomal RNA HGH94_13645 ENOG4105TQK DNA polymerase iii, delta' subunit HGH94_13660 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 HGH94_13670 ENOG4105KQC Competence protein HGH94_13680 ENOG4108D32 Methyltransferase HGH94_13690 ENOG4108WF2 Metal Dependent Phosphohydrolase HGH94_13695 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) HGH94_13700 ENOG410812S Rna-binding protein HGH94_13705 ENOG4105E2X shikimate dehydrogenase HGH94_13710 ENOG4105CQW ribosome biogenesis GTPase YqeH HGH94_13715 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase HGH94_13730 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase HGH94_13735 ENOG41080BT SNARE associated Golgi HGH94_13755 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HGH94_13775 ENOG4105D3P Mannan endo-1,4-beta-mannosidase HGH94_13780 ENOG41087NI Sulfite exporter TauE/SafE HGH94_13785 ENOG4105VFE sira family HGH94_13790 ENOG4107TPS domain protein HGH94_13800 ENOG4105VFE sira family HGH94_13810 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase HGH94_13815 ENOG4105XTG Pfam:DUF156 HGH94_13825 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein HGH94_13835 ENOG41090E6 transcriptional regulator MERR family HGH94_13850 ENOG4105C37 (CBS) domain HGH94_13865 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family HGH94_13875 ENOG4105PGM cation diffusion facilitator family transporter HGH94_13880 ENOG41090U3 tautomerase HGH94_13900 ENOG4105KMT branched-chain amino acid HGH94_13910 ENOG4108ZRZ Transcriptional regulator (AsnC family) HGH94_13915 ENOG41067XF inhibitor HGH94_13940 ENOG41064BW Protein of unknown function (DUF2568) HGH94_13960 ENOG41075D4 Aminoglycoside 6-adenylyltransferase HGH94_13965 ENOG4105EA8 2-Nitropropane dioxygenase HGH94_13970 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HGH94_13990 ENOG4108MEK Metal-binding protein YodA HGH94_13995 ENOG410904A RNA polymerase HGH94_14000 ENOG4105CPC Aldo Keto reductase HGH94_14010 ENOG4108KAM Transcriptional regulator HGH94_14015 ENOG4105C7F AcnD-accessory protein PrpF HGH94_14025 ENOG4105X5K response regulator receiver protein HGH94_14030 ENOG4108VQT Alpha beta hydrolase fold protein HGH94_14035 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein HGH94_14040 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein HGH94_14050 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase HGH94_14060 ENOG4105PGS Spore coat protein HGH94_14065 ENOG4105E2A Dehydrogenase HGH94_14090 ENOG4105VUF Transcriptional regulator HGH94_14100 ENOG4105DQ4 alcohol dehydrogenase HGH94_14105 ENOG4108Z0Z intracellular protease Pfpi family HGH94_14115 ENOG4105F3R pts system mannose fructose sorbose family iid HGH94_14120 ENOG4105ETZ PTS System HGH94_14125 ENOG4108IQ3 PTS system HGH94_14130 ENOG4105YHU PTS system HGH94_14135 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HGH94_14145 ENOG4105C85 amino acid HGH94_14150 ENOG4105N14 lysine exporter protein LysE YggA HGH94_14155 ENOG4108NGU Transcriptional regulator HGH94_14160 ENOG4105JVQ RNA Polymerase HGH94_14165 ENOG4108P49 AntiSigma factor HGH94_14170 ENOG4105EXC Acyl-transferase HGH94_14175 ENOG4105WDR HGH94_14180 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) HGH94_14185 ENOG41082JN Transcriptional regulator HGH94_14205 ENOG4105TMB Formate nitrite transporter HGH94_14210 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) HGH94_14230 ENOG4105C28 cystathionine HGH94_14245 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) HGH94_14260 ENOG4107XRG penicillin-binding protein HGH94_14265 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HGH94_14270 ENOG4105DBI uridine monophosphokinase HGH94_14275 ENOG4105CFP Peptidase U32 HGH94_14280 ENOG4105XYU peptidase (U32 family) HGH94_14290 ENOG4105HHA aminodeoxychorismate lyase HGH94_14295 ENOG4105VPH UPF0473 protein HGH94_14300 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) HGH94_14305 ENOG4105VBH UPF0297 protein HGH94_14310 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HGH94_14315 ENOG4105C02 permease HGH94_14320 ENOG4105CDA abc transporter atp-binding protein HGH94_14325 ENOG4105CT1 (ABC) transporter HGH94_14330 ENOG4105EAD ABC transporter HGH94_14335 ENOG4105DRP amino acid AbC transporter HGH94_14345 ENOG41060CR HGH94_14355 ENOG4105C7H Helicase, RecD TraA family HGH94_14365 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) HGH94_14370 ENOG4105C3J Cysteine desulfurase HGH94_14380 ENOG4105D1H recombination factor protein RarA HGH94_14395 ENOG4105C9M aspartyl-trna synthetase HGH94_14400 ENOG4105CUT histidyl-tRNA synthetase HGH94_14410 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HGH94_14420 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HGH94_14425 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) HGH94_14430 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HGH94_14435 ENOG41067VP Protein of unknown function (DUF1049) HGH94_14440 ENOG4105NCW Trka-c domain protein HGH94_14445 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HGH94_14455 ENOG4105CKP Polysaccharide Biosynthesis Protein HGH94_14460 ENOG4108QG2 Membrane HGH94_14465 ENOG4105NAP HGH94_14470 ENOG4105VIE preprotein translocase, subunit YajC HGH94_14475 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) HGH94_14480 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HGH94_14485 ENOG41061AI Protein of unknown function (DUF2905) HGH94_14490 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) HGH94_14495 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HGH94_14505 ENOG4105IE8 Alpha-ketoglutarate permease HGH94_14535 ENOG4105BZG amino acid carrier protein HGH94_14540 ENOG4105CDY transcriptional regulatory protein HGH94_14550 ENOG4106678 morphogenetic protein associated with SpoVID HGH94_14555 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HGH94_14560 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HGH94_14565 ENOG4108IYU L-aspartate oxidase HGH94_14580 ENOG4105CQC Prephenate dehydratase HGH94_14585 ENOG41090I5 UPF0735 ACT domain-containing protein HGH94_14590 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HGH94_14605 ENOG4105K46 50S ribosomal protein l27 HGH94_14610 ENOG4105X36 (ribosomal) protein HGH94_14615 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) HGH94_14630 ENOG4107QMS site-determining protein HGH94_14635 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HGH94_14640 ENOG4105YHC Rod shape-determining protein MreD HGH94_14655 ENOG4105W5Q DNA repair protein (RadC HGH94_14670 ENOG4106A3R peptidase HGH94_14675 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HGH94_14680 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HGH94_14690 ENOG4106AR7 Spore coat protein HGH94_14695 ENOG41068KH stage VI sporulation protein D HGH94_14700 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase HGH94_14705 ENOG4105D52 delta-aminolevulinic acid dehydratase HGH94_14715 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HGH94_14725 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HGH94_14735 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) HGH94_14740 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HGH94_14745 ENOG4108IUQ atp-dependent protease HGH94_14750 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) HGH94_14755 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation HGH94_14765 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HGH94_14775 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HGH94_14780 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) HGH94_14785 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase HGH94_14790 ENOG4108ZP8 Acetolactate synthase small subunit HGH94_14795 ENOG4105C7K acetolactate synthase HGH94_14805 ENOG4105I4A GCN5-related N-acetyltransferase HGH94_14810 ENOG4107KM7 Heat induced stress protein YflT HGH94_14820 ENOG4105M59 Phosphodiesterase, mj0936 family HGH94_14825 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HGH94_14830 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) HGH94_14835 ENOG4108XJQ germination protein HGH94_14840 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HGH94_14850 ENOG4105PFC Transcriptional regulator HGH94_14860 ENOG4105E33 succinate dehydrogenase HGH94_14870 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit HGH94_14885 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) HGH94_14890 ENOG4105K63 Thioredoxin HGH94_14895 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HGH94_14900 ENOG4105C10 Electron transfer flavoprotein HGH94_14905 ENOG4105BZJ Electron transfer flavoprotein HGH94_14910 ENOG41060WC Enoyl-CoA hydratase HGH94_14915 ENOG4107Z3H Transcriptional regulator, TetR family HGH94_14930 ENOG4105C98 muts2 protein HGH94_14950 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HGH94_14955 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HGH94_14960 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) HGH94_14970 ENOG4108RWN rrna methyltransferase HGH94_14975 ENOG41067MF small acid-soluble spore protein HGH94_14985 ENOG4105CQB FAD linked oxidase domain protein HGH94_14990 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HGH94_15005 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) HGH94_15010 ENOG4105DRS transport system, permease HGH94_15025 ENOG4108MDK Dehydrogenase HGH94_15035 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HGH94_15040 ENOG4105EF1 ribulokinase HGH94_15050 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase HGH94_15055 ENOG4105CN9 Peptidase m42 family protein HGH94_15065 ENOG410696E Membrane HGH94_15070 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) HGH94_15075 ENOG4105VJV 50s ribosomal protein L35 HGH94_15080 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HGH94_15090 ENOG41067MG lrgb family HGH94_15100 ENOG4105DY9 regulatoR HGH94_15105 ENOG4108HRK Histidine kinase HGH94_15115 ENOG4105C22 threonyL-tRNA synthetase HGH94_15120 ENOG4108TDW sporulation protein YtxC HGH94_15140 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) HGH94_15145 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) HGH94_15160 ENOG4105F27 Major Facilitator HGH94_15165 ENOG4105CV8 reductase HGH94_15175 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HGH94_15185 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HGH94_15190 ENOG4105C2M dna polymerase I HGH94_15195 ENOG4105BZU Histidine kinase HGH94_15200 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HGH94_15205 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) HGH94_15210 ENOG4108HMX isocitrate dehydrogenase (NADP) HGH94_15215 ENOG4105BZN citrate synthase HGH94_15225 ENOG4108REF Sporulation integral membrane protein ytvi HGH94_15235 ENOG4105CA9 Pyruvate kinase HGH94_15240 ENOG4105CTQ phosphohexokinase HGH94_15255 ENOG4105C6K Malic enzyme HGH94_15260 ENOG4105C0B DNA polymerase III (alpha subunit) HGH94_15265 ENOG4105VV2 HGH94_15275 ENOG4106EVM HGH94_15280 ENOG4105SFS phosphoesterase RecJ domain protein HGH94_15295 ENOG410635A Membrane HGH94_15320 ENOG4105DEN Luciferase family HGH94_15325 ENOG4105CDA abc transporter atp-binding protein HGH94_15350 ENOG4108XSB acetyltransferase, (GNAT) family HGH94_15355 ENOG4108KSA LysR family transcriptional regulator HGH94_15360 ENOG4105E8R UPF0173 metal-dependent hydrolase HGH94_15370 ENOG4105CH7 arginosuccinase HGH94_15375 ENOG4105CDH Citrulline--aspartate ligase HGH94_15380 ENOG4105EPU Molybdenum cofactor synthesis domain protein HGH94_15385 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HGH94_15400 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HGH94_15405 ENOG4105KBJ sporulation protein ytfj HGH94_15415 ENOG4105VK3 rdd domain containing protein HGH94_15425 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) HGH94_15430 ENOG4105EFZ amidohydrolase HGH94_15470 ENOG4105U5Y Transcriptional regulator HGH94_15485 ENOG4105BZU Histidine kinase HGH94_15495 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) HGH94_15505 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) HGH94_15515 ENOG4105F1V Acetoin utilization protein HGH94_15520 ENOG4105W87 Cbs domain HGH94_15525 ENOG4105DGU Histone deacetylase HGH94_15530 ENOG4105ER2 Ompa motb domain protein HGH94_15535 ENOG4107R0U MotA TolQ exbB proton channel HGH94_15540 ENOG4105ETE Transcriptional regulator (LacI family HGH94_15545 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase HGH94_15565 ENOG4105DFU Cell wall formation (By similarity) HGH94_15575 ENOG4108VDD TRNA binding domain protein HGH94_15610 ENOG4105C6K Malic enzyme HGH94_15615 ENOG4105C8F Beta-lactamase domain protein HGH94_15620 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) HGH94_15630 ENOG4108V15 phosphotransferase enzyme family HGH94_15635 ENOG4108IUM Glycogen debranching enzyme HGH94_15650 ENOG4107F58 2'-5' rna ligase HGH94_15655 ENOG4105C6T cysteine synthase HGH94_15660 ENOG4107QSE Dipeptidase HGH94_15680 ENOG4105YW5 deoR family transcriptional regulator HGH94_15695 ENOG4105CBX hi0933 family HGH94_15725 ENOG4105F5H Glycosyl Hydrolase Family 88 HGH94_15745 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component HGH94_15760 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) HGH94_15770 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HGH94_15780 ENOG4108W8G Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity) HGH94_15785 ENOG4105NTD Inherit from COG: Hydrolase HGH94_15815 ENOG41085GJ domain protein HGH94_15820 ENOG4105C8T Leucyl-tRNA synthetase HGH94_15830 ENOG4105BZU Histidine kinase HGH94_15835 ENOG410605W Major Facilitator HGH94_15840 ENOG4106UBQ HGH94_15860 ENOG4105C19 ABC transporter HGH94_15865 ENOG4105EWM Histidine kinase HGH94_15875 ENOG4107R34 abc transporter permease protein HGH94_15880 ENOG4105C19 ABC transporter HGH94_15895 ENOG4105DVE abc transporter atp-binding protein HGH94_15900 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family HGH94_15915 ENOG4105N5T Radical SAM Protein HGH94_15930 ENOG4105E8V Alpha Beta Hydrolase Fold protein HGH94_15935 ENOG4108Z0R Transferase HGH94_15940 ENOG4105C85 amino acid HGH94_15950 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP HGH94_15955 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase HGH94_15970 ENOG4105D2X ABC transporter substrate-binding protein HGH94_15980 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component HGH94_15995 ENOG4108RMU ferritin dps family protein HGH94_16010 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) HGH94_16015 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) HGH94_16020 ENOG4108V2W Carbonate dehydratase HGH94_16045 ENOG4105CC5 ABC transporter HGH94_16050 ENOG4105CC5 ABC transporter HGH94_16055 ENOG4105DIK (ABC) transporter HGH94_16060 ENOG4105DSE periplasmic solute binding protein HGH94_16065 ENOG4105DTQ mandelate racemase muconate lactonizing HGH94_16075 ENOG4108IPT Naphthoate synthase HGH94_16080 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HGH94_16085 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) HGH94_16090 ENOG4105E4F Isochorismate synthase HGH94_16110 ENOG4108IAJ Nad-dependent epimerase dehydratase HGH94_16115 ENOG4107SBE Glycosyl transferase (Group 1 HGH94_16130 ENOG4107SBE Glycosyl transferase (Group 1 HGH94_16135 ENOG4108KS4 Spore coat protein HGH94_16150 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) HGH94_16290 ENOG4105N67 Proton-coupled thiamine transporter YuaJ HGH94_16295 ENOG4105VRR gCN5-related N-acetyltransferase HGH94_16300 ENOG4105DZ6 Band 7 protein HGH94_16310 ENOG4106DF1 HGH94_16315 ENOG4108VNY MOSC domain protein HGH94_16320 ENOG4108JB8 alcohol dehydrogenase HGH94_16330 ENOG4105TRT Transcriptional regulator HGH94_16350 ENOG4105CZN Potassium uptake protein HGH94_16355 ENOG4107I77 yiaA/B two helix domain HGH94_16360 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HGH94_16380 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) HGH94_16390 ENOG4105EE0 oxidoreductase HGH94_16395 ENOG4105DKG l-rhamnose isomerase HGH94_16400 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) HGH94_16405 ENOG4105DET Rhamnulokinase HGH94_16410 ENOG4105E98 transcriptional regulator DeoR family HGH94_16420 ENOG4105C8Q Methyl-accepting chemotaxis HGH94_16435 ENOG4105C8Q Methyl-accepting chemotaxis HGH94_16455 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HGH94_16470 ENOG4105C37 (CBS) domain HGH94_16485 ENOG4107PBV potassium channel HGH94_16490 ENOG4107PBV potassium channel HGH94_16505 ENOG4107QYV phosphohexose isomerase HGH94_16515 ENOG4107QW4 alcohol dehydrogenase HGH94_16520 ENOG4105WG9 Conserved Protein HGH94_16530 ENOG4105CHM Aminotransferase HGH94_16535 ENOG4108ZB6 transcriptional regulator AsnC family HGH94_16540 ENOG4108MUZ hydrolase HGH94_16550 ENOG4105C87 Aminotransferase class I and II HGH94_16555 ENOG4108HGU Histidine kinase HGH94_16560 ENOG4105Y38 Kinase-associated protein B HGH94_16580 ENOG4105BZ4 penicillin-binding protein HGH94_16585 ENOG4105KIR Thiol-disulfide oxidoreductase dcc HGH94_16600 ENOG4108MRH transcriptional regulatory protein HGH94_16605 ENOG4105DIH basic membrane HGH94_16610 ENOG4108JQ9 ABC transporter HGH94_16615 ENOG4105UIB (ABC) transporter HGH94_16635 ENOG4105D65 subunit l HGH94_16640 ENOG4105HC0 Na H antiporter HGH94_16645 ENOG4108ZE9 Monovalent cation H antiporter subunit C HGH94_16650 ENOG4108JPZ Monovalent cation H antiporter subunit D HGH94_16655 ENOG4105SC1 monovalent cation H antiporter subunit E HGH94_16665 ENOG4105KJM monovalent cation h antiporter subunit g HGH94_16670 ENOG4105KA0 thioesterase Superfamily protein HGH94_16710 ENOG4105D58 Diguanylate phosphodiesterase HGH94_16715 ENOG4105DAP Nicotinate phosphoribosyltransferase HGH94_16740 ENOG4105C02 permease HGH94_16760 ENOG410904N short-chain dehydrogenase reductase HGH94_16795 ENOG4108K8K Transcriptional regulator HGH94_16800 ENOG4105DCF alanine dehydrogenase HGH94_16810 ENOG4105WQT MbtH domain protein HGH94_16820 ENOG4105WQI isochorismatase HGH94_16825 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HGH94_16830 ENOG4105E4F Isochorismate synthase HGH94_16835 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HGH94_16840 ENOG4105NIV Esterase HGH94_16860 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HGH94_16870 ENOG41069ER domain protein HGH94_16890 ENOG4105CAY ferredoxin--nadp reductase HGH94_16915 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 HGH94_16920 ENOG4108YX9 iron--sulfur cluster insertion protein erpA HGH94_16935 ENOG4105ZKE UPF0349 protein HGH94_16950 ENOG41083MR nifu domain-containing protein HGH94_16960 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) HGH94_16965 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) HGH94_16970 ENOG4105D6E homoserine dehydrogenase HGH94_16985 ENOG4105D4U had-superfamily hydrolase, subfamily iia HGH94_16995 ENOG4105MMD transcriptional regulator HGH94_17000 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) HGH94_17005 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) HGH94_17015 ENOG4108YTE sporulation protein YunB HGH94_17020 ENOG4105KZD Domain of unknown function (DUF1805) HGH94_17025 ENOG4107R8B 5'-nucleotidase HGH94_17035 ENOG4105I3N Conserved Protein HGH94_17045 ENOG4105CD3 dihydroorotase HGH94_17050 ENOG4105G9B Transcriptional regulator HGH94_17065 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) HGH94_17070 ENOG4105VT2 5-hydroxyisourate hydrolase HGH94_17080 ENOG4107YV9 domain protein HGH94_17085 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding HGH94_17100 ENOG4105XRQ Xanthine dehydrogenase accessory factor HGH94_17105 ENOG4105C5R Aminotransferase HGH94_17120 ENOG4108K8S endonuclease I HGH94_17160 ENOG4105CFH Aspartokinase HGH94_17165 ENOG4108IJ9 (ABC) transporter HGH94_17170 ENOG4105FDP GntR family transcriptional regulator HGH94_17190 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HGH94_17200 ENOG4107VFR oxidoreductase HGH94_17220 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase HGH94_17225 ENOG4105NPE arsR family transcriptional regulator HGH94_17230 ENOG4105DIW FeS assembly protein SUFB HGH94_17235 ENOG4108UNV SUF system FeS assembly protein, NifU family HGH94_17240 ENOG4105C9B Cysteine desulfurase HGH94_17245 ENOG4105JRK feS assembly protein SufD HGH94_17250 ENOG4105C3K feS assembly ATPase SufC HGH94_17265 ENOG4105D01 (LipO)protein HGH94_17270 ENOG4108UMI ABC transporter, permease HGH94_17275 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HGH94_17300 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) HGH94_17305 ENOG41080E8 Transcriptional regulator, Spx MgsR family HGH94_17310 ENOG4105C1G acyl-Coa dehydrogenase HGH94_17315 ENOG4105CHU acetyl-coa acetyltransferase HGH94_17345 ENOG41067TZ transcriptional regulator, MarR family HGH94_17350 ENOG4105C0R drug resistance transporter emrb qaca subfamily HGH94_17355 ENOG4105MDS 4-oxalocrotonate tautomerase HGH94_17375 ENOG4105E0A ABC, transporter HGH94_17390 ENOG4105E1F short-chain dehydrogenase reductase HGH94_17395 ENOG4105HUF DNA protection during starvation protein HGH94_17400 ENOG4105C0H protease HGH94_17410 ENOG4105F3H Histidine kinase HGH94_17420 ENOG41067SE Tetr family transcriptional regulator HGH94_17425 ENOG4105C9Q fumarate hydratase class II HGH94_17450 ENOG4105WH1 Two component transcriptional regulator luxr family HGH94_17455 ENOG4105ENE Histidine kinase HGH94_17470 ENOG41087YS Phage shock protein A HGH94_17485 ENOG4108WBT adenosyltransferase HGH94_17490 ENOG4105E0A ABC, transporter HGH94_17495 ENOG4105EHG Permease protein HGH94_17500 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HGH94_17505 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HGH94_17510 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein HGH94_17520 ENOG4105DPZ Two component transcriptional regulator (Winged helix family HGH94_17530 ENOG4106DF4 Sigma-70, region 4 HGH94_17540 ENOG4105F0F Oxalate decarboxylase HGH94_17550 ENOG4107RBB ABC transporter, permease HGH94_17555 ENOG4105C19 ABC transporter HGH94_17560 ENOG4108WMK Efflux transporter RND family MFP subunit HGH94_17565 ENOG4105E0A ABC, transporter HGH94_17570 ENOG4105EHG Permease protein HGH94_17575 ENOG4105DQ5 transport system permease protein HGH94_17585 ENOG4105D5Q Arginine ornithine antiporter HGH94_17595 ENOG4107K5X Membrane-bound metal-dependent hydrolase HGH94_17600 ENOG4107QZ2 Sulfatase HGH94_17605 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family HGH94_17610 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HGH94_17615 ENOG4105E0C molybdate abc transporter HGH94_17630 ENOG4105EEQ Na H antiporter HGH94_17635 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HGH94_17645 ENOG4105EEM helicase HGH94_17650 ENOG4105EN6 Membrane HGH94_17660 ENOG4107ZQN disulfide bond HGH94_17665 ENOG4105C59 p-type ATPase HGH94_17675 ENOG410681U heavy metal transport detoxification protein HGH94_17680 ENOG4105VPX protein, conserved in bacteria HGH94_17685 ENOG4105D9R oxidoreductase HGH94_17690 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HGH94_17695 ENOG4105ME7 Membrane HGH94_17700 ENOG4105RXJ HGH94_17705 ENOG4105KPY Small multidrug resistance protein HGH94_17710 ENOG4105KBX Transcriptional regulator, TetR family HGH94_17715 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HGH94_17725 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) HGH94_17730 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HGH94_17740 ENOG4105XZU Preprotein translocase, subunit SecG HGH94_17765 ENOG4105KVH Transcriptional regulator HGH94_17775 ENOG4105R40 Glycine betaine carnitine choline HGH94_17780 ENOG4108HQR Glycine betaine HGH94_17785 ENOG4105E90 ABC transporter HGH94_17790 ENOG4108IJ8 ABC transporter HGH94_17795 ENOG4107HG4 Transcriptional regulator HGH94_17805 ENOG4105H5S HGH94_17820 ENOG41082BM Transcriptional regulator, arsr family HGH94_17825 ENOG4105R40 Glycine betaine carnitine choline HGH94_17830 ENOG4108HQR Glycine betaine HGH94_17835 ENOG4105E90 ABC transporter HGH94_17840 ENOG4108IJ8 ABC transporter HGH94_17845 ENOG4107HG4 Transcriptional regulator HGH94_17850 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HGH94_17855 ENOG4108QCI YvbH-like oligomerisation region HGH94_17865 ENOG4105T65 Membrane-associated protein HGH94_17870 ENOG4108W0I acetyltransferase HGH94_17875 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) HGH94_17880 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HGH94_17885 ENOG4105CP7 Triose-phosphate isomerase HGH94_17890 ENOG4105BZA Phosphoglycerate kinase HGH94_17895 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HGH94_17910 ENOG4105CMD Transcriptional regulator, GntR family HGH94_17915 ENOG4105DEN Luciferase family HGH94_17920 ENOG4105GZI Transcriptional regulator HGH94_17925 ENOG4107RT3 EamA-like transporter family HGH94_17935 ENOG4105VRS hydrolase family 18 HGH94_17940 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HGH94_17945 ENOG4107QR9 Iron-sulfur cluster binding protein HGH94_17950 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HGH94_17975 ENOG4105KCT ABC transporter HGH94_17985 ENOG4107R6F Alpha Beta Hydrolase Fold protein HGH94_17990 ENOG4108MJI response regulator HGH94_18005 ENOG4105EG2 ABC transporter, permease HGH94_18025 ENOG4105JXH GntR family transcriptional regulator HGH94_18030 ENOG4105DAA L-lactate HGH94_18035 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HGH94_18045 ENOG4108ZPC Polysaccharide pyruvyl transferase HGH94_18050 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HGH94_18055 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family HGH94_18060 ENOG4105D3Q Sugar transferase HGH94_18075 ENOG4107QRS glycosyltransferase group 2 family protein HGH94_18080 ENOG41068W6 Capsular polysaccharide biosynthesis protein HGH94_18085 ENOG4108KMV Glycosyl transferase (Group 1 HGH94_18090 ENOG4105K64 Glycosyl transferase, family 2 HGH94_18095 ENOG4108PQP glycosyl transferase group 1 HGH94_18105 ENOG4108QV3 biosynthesis protein HGH94_18110 ENOG4105HTX biosynthesis protein HGH94_18120 ENOG4105EBR Carboxylesterase HGH94_18130 ENOG4105PY6 Phenolic acid decarboxylase HGH94_18135 ENOG4105NI3 Protein of unknown function (DUF3237) HGH94_18145 ENOG4105FQP Beta-lactamase HGH94_18155 ENOG4108HKT sucrose-6-phosphate hydrolase HGH94_18160 ENOG4107QTZ amino acid HGH94_18190 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HGH94_18195 ENOG4107URF beta-phospho-glucomutase HGH94_18200 ENOG4105CG3 alpha amylase, catalytic region HGH94_18215 ENOG4105EG2 ABC transporter, permease HGH94_18220 ENOG4105D56 permease protein HGH94_18225 ENOG4107FKK extracellular solute-binding protein family 1 HGH94_18230 ENOG4108IUK alpha amylase, catalytic HGH94_18235 ENOG4105FKQ transcriptional regulator HGH94_18240 ENOG4108URH decarboxylase HGH94_18245 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain HGH94_18250 ENOG4105CHH sulfate transporter HGH94_18255 ENOG4108V2W Carbonate dehydratase HGH94_18260 ENOG4105C5I Dehydrogenase HGH94_18270 ENOG4105C19 ABC transporter HGH94_18275 ENOG4105EWM Histidine kinase HGH94_18285 ENOG4107A6P HGH94_18290 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HGH94_18295 ENOG4105KRI phosphocarrier protein (HPr HGH94_18300 ENOG4105CIE May be required for sporulation (By similarity) HGH94_18305 ENOG4105CHW UPF0052 protein HGH94_18310 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) HGH94_18315 ENOG4108Z4K mutator MutT protein HGH94_18320 ENOG4105C3M thioredoxin reductase HGH94_18335 ENOG4105BZ1 (ABC) transporter HGH94_18345 ENOG4106FGC HGH94_18355 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HGH94_18360 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HGH94_18365 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HGH94_18370 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HGH94_18375 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HGH94_18380 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HGH94_18385 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) HGH94_18400 ENOG4108E16 pectate lyase HGH94_18405 ENOG4108S4C acetyltransferase HGH94_18410 ENOG4107XGZ Hydrolase HGH94_18420 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) HGH94_18425 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) HGH94_18430 ENOG4105CE4 GlcNAc 6-P deacetylase HGH94_18435 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) HGH94_18445 ENOG41088CQ domain protein HGH94_18455 ENOG4106A3M Cytochrome p-450 HGH94_18460 ENOG410625E HGH94_18475 ENOG41086DT Membrane protein of unknown function HGH94_18480 ENOG41067S9 phage shock protein C, PspC HGH94_18485 ENOG4108PY7 HGH94_18500 ENOG4105I03 Flagellin HGH94_18510 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) HGH94_18525 ENOG4105MKU Transcriptional regulator HGH94_18550 ENOG4105CRP Part of the ABC transporter FtsEX involved in HGH94_18555 ENOG4105CAK Cell division ATP-binding protein ftsE HGH94_18595 ENOG4105MQ3 flagellar protein FliS HGH94_18600 ENOG4107RT6 flagellar hook-associated HGH94_18605 ENOG41083S7 flagellar protein FlaG HGH94_18610 ENOG4105I03 Flagellin HGH94_18620 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) HGH94_18625 ENOG4105MKD HGH94_18635 ENOG4105E1Q flagellar hook-associated protein HGH94_18650 ENOG4105RU3 HGH94_18675 ENOG4105WH1 Two component transcriptional regulator luxr family HGH94_18680 ENOG4105BZU Histidine kinase HGH94_18685 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HGH94_18690 ENOG4108KGH TRANSCRIPTIONal HGH94_18695 ENOG4105ESV Glycosyl transferase, family 4 HGH94_18700 ENOG4107EF8 Glycosyl transferase (Group 1 HGH94_18715 ENOG4105QZI O-Antigen Polymerase HGH94_18720 ENOG4105C6Y Udp-glucose 6-dehydrogenase HGH94_18730 ENOG4105PSV Polysaccharide Biosynthesis Protein HGH94_18735 ENOG4105D3Q Sugar transferase HGH94_18740 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HGH94_18745 ENOG4105JFG SpoIID LytB domain protein HGH94_18760 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HGH94_18765 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HGH94_18775 ENOG4107VDP teichoic acid biosynthesis HGH94_18780 ENOG41088M2 Glycosyl transferase family 2 HGH94_18790 ENOG4107SJB teichoic acid biosynthesis HGH94_18800 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HGH94_18805 ENOG4105EY8 ABC transporter HGH94_18815 ENOG4107SJB teichoic acid biosynthesis HGH94_18820 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) HGH94_18825 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase HGH94_18850 ENOG4105DG6 mannose-6-phosphate isomerase HGH94_18865 ENOG4108NHD germination protein HGH94_18875 ENOG4108KGH TRANSCRIPTIONal HGH94_18880 ENOG4105J7I hydrolase HGH94_18890 ENOG4105K4H Nlp p60 protein HGH94_18900 ENOG4105PNM synthesis protein HGH94_18910 ENOG4105N98 Capsule biosynthesis protein capB HGH94_18915 ENOG4105ETE Transcriptional regulator (LacI family HGH94_18920 ENOG4108RVA ribokinase HGH94_18925 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HGH94_18930 ENOG4105C2J ABC transporter HGH94_18935 ENOG4105CNN ABC, transporter HGH94_18940 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HGH94_18955 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein HGH94_18960 ENOG4107FQX Alpha-acetolactate decarboxylase HGH94_18970 ENOG4107RSM transcriptional regulator HGH94_19000 ENOG4107XC4 flavin reductase domain protein, FMN-binding HGH94_19010 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HGH94_19025 ENOG4105FGV Chromate HGH94_19035 ENOG4108WS4 fmn reductase HGH94_19040 ENOG4107V2S Transcriptional regulator HGH94_19045 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) HGH94_19090 ENOG4108XI2 Domain of unknown function (DUF1963) HGH94_19095 ENOG4105C6Y Udp-glucose 6-dehydrogenase HGH94_19100 ENOG4108RB3 Capsular polysaccharide biosynthesis protein HGH94_19105 ENOG4107YJ4 chain length determinant protein HGH94_19110 ENOG4105HTX biosynthesis protein HGH94_19120 ENOG4105KBK Zinc finger, swim domain protein HGH94_19125 ENOG4105C0D helicase HGH94_19130 ENOG410667J hydrolase HGH94_19135 ENOG4105E98 transcriptional regulator DeoR family HGH94_19140 ENOG4105Z8H single-stranded DNA-binding protein HGH94_19170 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) HGH94_19175 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HGH94_19185 ENOG4105CGA flagellar basal-body rod protein FlgG HGH94_19200 ENOG4105MT0 Sporulation transcriptional regulator spoiiid HGH94_19210 ENOG4107MII Sugar-specific transcriptional regulator TrmB HGH94_19215 ENOG4105CZM Major Facilitator HGH94_19220 ENOG4108M26 parallel beta-helix repeat protein HGH94_19225 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HGH94_19230 ENOG41080V3 Major Facilitator superfamily HGH94_19235 ENOG4105D3W isochorismatase HGH94_19240 ENOG4107P26 HGH94_19245 ENOG4105BZU Histidine kinase HGH94_19265 ENOG4105FRN stage II sporulation protein HGH94_19270 ENOG4107TCE N-acetyltransferase HGH94_19295 ENOG4107TXC Transcriptional regulator HGH94_19300 ENOG4106BRK HGH94_19305 ENOG4108RYK Nad-dependent epimerase dehydratase HGH94_19310 ENOG4108Z40 Transcriptional regulator HGH94_19315 ENOG4105CQM Urea amidohydrolase subunit alpha HGH94_19320 ENOG4105KI2 Urea amidohydrolase subunit beta HGH94_19325 ENOG4108YZ9 Urea amidohydrolase subunit gamma HGH94_19330 ENOG4108IV0 ABC, transporter HGH94_19335 ENOG4105C0Z ABC transporter HGH94_19345 ENOG4105C32 Amino acid ABC transporter (Permease) HGH94_19350 ENOG4107TSX ABC branched chain amino acid family transporter periplasmic ligand binding protein HGH94_19375 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HGH94_19385 ENOG4108TF4 von Willebrand factor, type A HGH94_19400 ENOG4105JFG SpoIID LytB domain protein HGH94_19405 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HGH94_19415 ENOG4106778 Protein of unknown function (DUF1146) HGH94_19425 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) HGH94_19430 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) HGH94_19435 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) HGH94_19440 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) HGH94_19460 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) HGH94_19470 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) HGH94_19475 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) HGH94_19480 ENOG4108UIC UPF0340 protein HGH94_19485 ENOG4108YZG isomerase HGH94_19490 ENOG4107WAU Protein tyrosine phosphatase HGH94_19495 ENOG410815N Probably functions as a manganese efflux pump (By similarity) HGH94_19500 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HGH94_19510 ENOG4108ZXQ stage ii sporulation protein r HGH94_19525 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HGH94_19530 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) HGH94_19535 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HGH94_19545 ENOG4107TT2 Auxin Efflux Carrier HGH94_19550 ENOG4105C6K Malic enzyme HGH94_19555 ENOG4107104 thymidine kinase HGH94_19565 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HGH94_19575 ENOG4105CBT Fructose-1,6-bisphosphatase HGH94_19580 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) HGH94_19585 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway HGH94_19590 ENOG4105D2N Aldolase HGH94_19595 ENOG410812K response regulator receiver protein HGH94_19610 ENOG4105DQ6 Transposase HGH94_19615 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) HGH94_19625 ENOG4105C1G acyl-Coa dehydrogenase HGH94_19630 ENOG4105DF6 Fe-S oxidoreductase HGH94_19640 ENOG4105E5J UV damage endonuclease HGH94_19650 ENOG4105NAE bifunctional deaminase-reductase domain protein HGH94_19655 ENOG4105BZ1 (ABC) transporter HGH94_19660 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) HGH94_19675 ENOG4105R3A Nitrate reductase HGH94_19700 ENOG4107V6Q Cyclic nucleotide-binding domain HGH94_19710 ENOG4105C75 arginyL-tRNA synthetase HGH94_19715 ENOG410684U Domain of unknown function (DUF1934) HGH94_19730 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E HGH94_19780 ENOG4107JM4 Tetratricopeptide repeat HGH94_19795 ENOG4105CYW agmatinase HGH94_19800 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) HGH94_19805 ENOG4105BZ4 penicillin-binding protein HGH94_19810 ENOG4108XFG YwhD family HGH94_19815 ENOG4108Z4T Peptidase M50 HGH94_19820 ENOG41069HH 4-oxalocrotonate tautomerase HGH94_19825 ENOG41067TZ transcriptional regulator, MarR family HGH94_19830 ENOG4105C22 threonyL-tRNA synthetase HGH94_19840 ENOG4105C57 major facilitator superfamily HGH94_19845 ENOG41062ES Transcriptional regulator HGH94_19855 ENOG4105DCI Phosphohydrolase HGH94_19865 ENOG4108VCI transcription factor, rsfa family HGH94_19870 ENOG4108RNG Permease of the drug metabolite transporter HGH94_19875 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) HGH94_19880 ENOG4105DUM transcriptional regulator, lysR family HGH94_19885 ENOG4108IJ2 phosphate acetyltransferase HGH94_19910 ENOG4105CHR reductase HGH94_19940 ENOG4105C26 Dehydrogenase HGH94_19955 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase HGH94_19960 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HGH94_19965 ENOG4105C1B dTDP-glucose 4-6-dehydratase HGH94_19970 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HGH94_19975 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG HGH94_19980 ENOG4107TY6 Acylneuraminate cytidylyltransferase HGH94_19990 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD HGH94_20030 ENOG4105C26 Dehydrogenase HGH94_20035 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) HGH94_20060 ENOG4105DWF phosphomethylpyrimidine kinase HGH94_20075 ENOG4105C5Y PTS System HGH94_20080 ENOG4108QTI )-transporter HGH94_20100 ENOG4105DEN Luciferase family HGH94_20105 ENOG4108DBC nitroreductase HGH94_20120 ENOG41060D1 Quinol oxidase HGH94_20125 ENOG4105CCU oxidase (Subunit III) HGH94_20130 ENOG4105BZ9 Cytochrome C oxidase, subunit I HGH94_20135 ENOG4105E2S oxidase) subunit II HGH94_20140 ENOG4107BMA Transglycosylase associated protein HGH94_20150 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) HGH94_20155 ENOG4105WH5 Teichoic acid glycosylation protein HGH94_20185 ENOG4105DBE peroxidase HGH94_20190 ENOG410650H (LipO)protein HGH94_20195 ENOG4107SJW iron permease, FTR1 HGH94_20200 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) HGH94_20215 ENOG4105VAW lrga family HGH94_20220 ENOG41067MG lrgb family HGH94_20225 ENOG4105D8G Major Facilitator superfamily HGH94_20235 ENOG4105DR4 Methyltransferase HGH94_20245 ENOG4108YV3 Protein of unknown function (DUF2711) HGH94_20250 ENOG4105CK1 PTS System HGH94_20255 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin HGH94_20270 ENOG4105X1N Glycosyl transferase family 8 HGH94_20280 ENOG4105GVJ transcriptional regulator HGH94_20290 ENOG4105IIU Aminopeptidase HGH94_20320 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HGH94_20340 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein HGH94_20350 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD HGH94_20355 ENOG4108VHC Short-chain dehydrogenase reductase Sdr HGH94_20360 ENOG4105CM2 brancheD-chain amino acid aminotransferase HGH94_20365 ENOG4105F8D glycoside hydrolase family 4 HGH94_20370 ENOG4105VCP PTS System HGH94_20380 ENOG4105VZJ PTS System HGH94_20385 ENOG4105EMD TRANSCRIPTIONal HGH94_20395 ENOG4108VX5 3-methyladenine DNA glycosylase HGH94_20400 ENOG4105CH6 catalase HGH94_20415 ENOG4105DA5 (ABC) transporter HGH94_20420 ENOG41069JR HGH94_20440 ENOG4105ETS cytosine purines uracil thiamine allantoin HGH94_20450 ENOG4108JJ8 (ABC) transporter HGH94_20455 ENOG4108JJ9 ABC, transporter HGH94_20460 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HGH94_20465 ENOG4105C4M (Ubiquinol oxidase) subunit I HGH94_20470 ENOG4105D2K citrate carrier protein HGH94_20485 ENOG4107BJW polysaccharide deacetylase HGH94_20505 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) HGH94_20515 ENOG4105CMR udp-glucose 4-epimerase HGH94_20525 ENOG4105BZU Histidine kinase HGH94_20530 ENOG4105WH1 Two component transcriptional regulator luxr family HGH94_20535 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HGH94_20565 ENOG4108IIH CoA-transferase subunit B HGH94_20570 ENOG4105D6N CoA-transferase, subunit a HGH94_20575 ENOG4105CY2 Citrate transporter HGH94_20580 ENOG4105DHI Methyltransferase HGH94_20585 ENOG4105H67 Protein of unknown function (DUF421) HGH94_20600 ENOG4108QY0 Membrane HGH94_20620 ENOG41090VF Stage v sporulation protein ac HGH94_20635 ENOG4105WEF catalase HGH94_20695 ENOG4105CH6 catalase HGH94_20705 ENOG4108RZ2 Glycoside hydrolase family 16 HGH94_20720 ENOG4105DEU major facilitator superfamily HGH94_20725 ENOG4105C1J atp-dependent rna helicase HGH94_20840 ENOG4107YZX Universal stress protein HGH94_20860 ENOG4107EV6 Inherit from COG: YD repeat protein HGH94_20895 ENOG4106Z5D Glycoside Hydrolase Family 43 HGH94_20910 ENOG4105C84 Histidine ammonia-lyase HGH94_20915 ENOG4105CGP Urocanate hydratase HGH94_20920 ENOG4105CI2 imidazolone-5-propionate hydrolase HGH94_20925 ENOG4107W25 arginase agmatinase formiminoglutamase HGH94_20935 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) HGH94_20940 ENOG4105D9N nucleoside HGH94_20950 ENOG4107RHR regulatoR HGH94_20955 ENOG4108TM9 integral membrane protein HGH94_20965 ENOG4108PGP mmge prpd family protein HGH94_20980 ENOG4108HW4 amino acid AbC transporter HGH94_20985 ENOG4105EAB amino acid AbC transporter HGH94_21000 ENOG4107QHE Choloylglycine hydrolase HGH94_21005 ENOG410667J hydrolase HGH94_21035 ENOG4108V5C ABC transporter HGH94_21065 ENOG4105D2N Aldolase HGH94_21070 ENOG4107TRN Xylose isomerase domain protein TIM barrel HGH94_21075 ENOG4105F0H myo-inositol catabolism protein HGH94_21080 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) HGH94_21090 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) HGH94_21095 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) HGH94_21100 ENOG4105D7K pfkb domain protein HGH94_21105 ENOG4105DH8 myo-inositol catabolism HGH94_21110 ENOG4105C26 Dehydrogenase HGH94_21120 ENOG4105CPC Aldo Keto reductase HGH94_21135 ENOG4107QNK )-transporter HGH94_21140 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HGH94_21150 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HGH94_21155 ENOG4105ST3 Transcriptional regulator HGH94_21160 ENOG4105C26 Dehydrogenase HGH94_21170 ENOG4108ITS PQQ enzyme repeat HGH94_21180 ENOG41085PJ rdd domain containing protein HGH94_21195 ENOG4105J7D transcriptional regulator HGH94_21200 ENOG4107JEE Short-chain dehydrogenase reductase Sdr HGH94_21210 ENOG41061AU MarR family Transcriptional regulator HGH94_21220 ENOG41067MG lrgb family HGH94_21235 ENOG4105BZW Glycerate kinase HGH94_21245 ENOG4105CMG Carbohydrate kinase HGH94_21250 ENOG4105C6Z Gluconate HGH94_21260 ENOG4105D3R alkyl hydroperoxide reductase HGH94_21265 ENOG4108JU3 Alkyl hydroperoxide reductase HGH94_21270 ENOG4105CS2 ec 3.2.1.21 HGH94_21280 ENOG4108S3Y transcriptional regulator HGH94_21290 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 HGH94_21340 ENOG4105E2A Dehydrogenase HGH94_21360 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) HGH94_21365 ENOG4105WQG acetyltransferase HGH94_21370 ENOG410780I phosphoprotein phosphatase activity HGH94_21380 ENOG41066UZ arginase EC 3.5.3.1 HGH94_21385 ENOG4108IQI permease HGH94_21390 ENOG4105C8Y Acetylornithine aminotransferase HGH94_21395 ENOG4108JUB Transcriptional regulator HGH94_21410 ENOG4105C0H protease HGH94_21415 ENOG4105Q2H domain protein HGH94_21435 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HGH94_21460 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis HGH94_21470 ENOG4105CDU Replicative dna helicase HGH94_21490 ENOG4105DJ2 Major Facilitator Superfamily HGH94_21495 ENOG4105EDW glycosyl transferase, family 39 HGH94_21500 ENOG4105K9Q Binds to the 23S rRNA (By similarity) HGH94_21505 ENOG4105BZR domain protein HGH94_21510 ENOG4108XMW Membrane HGH94_21525 ENOG4105KVH Transcriptional regulator HGH94_21530 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase HGH94_21550 ENOG41090E6 transcriptional regulator MERR family HGH94_21560 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein HGH94_21565 ENOG4105DDN Pentapeptide repeat-containing protein HGH94_21580 ENOG4108U05 Transcriptional regulator HGH94_21585 ENOG41082BV acetyltransferase HGH94_21595 ENOG4108U7W acetyltransferase HGH94_21600 ENOG4105UNS Pfam:DUF419 HGH94_21605 ENOG4105NAE bifunctional deaminase-reductase domain protein HGH94_21615 ENOG4108J8C transporter major facilitator family protein HGH94_21625 ENOG4105C7Z Conserved Protein HGH94_21630 ENOG4107FCW Abortive infection protein HGH94_21640 ENOG4108UW5 maltose o-acetyltransferase HGH94_21645 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase HGH94_21655 ENOG4105CGK Exodeoxyribonuclease III HGH94_21660 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HGH94_21670 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) HGH94_21675 ENOG4105C3G gtp-binding protein HGH94_21680 ENOG4108J2R molybdopterin oxidoreductase HGH94_21685 ENOG4105VDK protein, conserved in bacteria HGH94_21695 ENOG4108ZDA Sporulation protein YyaC HGH94_21700 ENOG4105FA0 parb-like partition protein HGH94_21720 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) HGH94_21725 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) HGH94_21730 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HGH94_21745 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)