locus-tag	class	description
HGH94_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HGH94_00010	COG0592	DNA-directed DNA polymerase activity
HGH94_00015	COG2501	S4 domain
HGH94_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HGH94_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HGH94_00070	COG0516	GMP reductase activity
HGH94_00070	COG0517	IMP dehydrogenase activity
HGH94_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HGH94_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HGH94_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HGH94_00100	COG1428	Deoxynucleoside kinase
HGH94_00105	COG1428	Deoxynucleoside kinase
HGH94_00110	COG3858	chitin binding
HGH94_00110	COG1388	LysM domain
HGH94_00115	COG1335	isochorismatase
HGH94_00120	COG0590	tRNA wobble adenosine to inosine editing
HGH94_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HGH94_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HGH94_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HGH94_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HGH94_00190	COG3853	Toxic anion resistance protein (TelA)
HGH94_00195	COG1982	Orn Lys Arg decarboxylase major
HGH94_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HGH94_00205	COG3870	Protein conserved in bacteria
HGH94_00210	COG1728	Protein conserved in bacteria
HGH94_00220	COG1774	PSP1 C-terminal conserved region
HGH94_00225	COG4467	Involved in initiation control of chromosome replication
HGH94_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HGH94_00235	COG2827	Endonuclease containing a URI domain
HGH94_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HGH94_00245	COG2002	toxin-antitoxin pair type II binding
HGH94_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGH94_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGH94_00255	COG0084	hydrolase, TatD family'
HGH94_00260	COG3584	3D domain protein
HGH94_00260	COG3583	domain protein
HGH94_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HGH94_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HGH94_00280	COG4466	Protein conserved in bacteria
HGH94_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HGH94_00300	COG0251	oxidation-reduction process
HGH94_00305	COG2088	sporulation resulting in formation of a cellular spore
HGH94_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HGH94_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HGH94_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HGH94_00325	COG0193	aminoacyl-tRNA hydrolase activity
HGH94_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HGH94_00340	COG2002	toxin-antitoxin pair type II binding
HGH94_00345	COG2244	polysaccharide biosynthetic process
HGH94_00350	COG3956	TIGRFAM MazG family protein
HGH94_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HGH94_00375	COG1098	S1 RNA binding domain
HGH94_00390	COG2208	phosphoserine phosphatase activity
HGH94_00400	COG0515	serine threonine protein kinase
HGH94_00405	COG0037	tRNA processing
HGH94_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HGH94_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HGH94_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HGH94_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HGH94_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HGH94_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HGH94_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HGH94_00470	COG1396	sequence-specific DNA binding
HGH94_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HGH94_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HGH94_00560	COG4463	regulation of RNA biosynthetic process
HGH94_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HGH94_00575	COG0542	response to heat
HGH94_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HGH94_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HGH94_00590	COG4956	integral membrane protein (PIN domain superfamily)
HGH94_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HGH94_00610	COG1045	serine acetyltransferase
HGH94_00615	COG0215	cysteine-tRNA ligase activity
HGH94_00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HGH94_00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HGH94_00630	COG3688	RNA-binding protein containing a PIN domain
HGH94_00635	COG1595	DNA-templated transcription, initiation
HGH94_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HGH94_00650	COG0250	Participates in transcription elongation, termination and antitermination
HGH94_00660	COG0081	regulation of translation
HGH94_00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HGH94_00675	COG2813	Specifically methylates the guanine in position
HGH94_00680	COG0085	RNA polymerase activity
HGH94_00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HGH94_00690	COG1358	cellular component organization or biogenesis
HGH94_00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HGH94_00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HGH94_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HGH94_00715	COG0596	Alpha beta hydrolase
HGH94_00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HGH94_00730	COG0088	Forms part of the polypeptide exit tunnel
HGH94_00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HGH94_00755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HGH94_00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HGH94_00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HGH94_00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HGH94_00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HGH94_00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HGH94_00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HGH94_00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HGH94_00820	COG0200	Binds to the 23S rRNA
HGH94_00825	COG0201	protein transport
HGH94_00830	COG0563	adenylate kinase activity
HGH94_00835	COG0024	Methionine aminopeptidase
HGH94_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HGH94_00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HGH94_00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HGH94_00865	COG0202	RNA polymerase activity
HGH94_00870	COG0203	ribosomal protein L17
HGH94_00875	COG1122	ATPase activity
HGH94_00880	COG1122	ATPase activity
HGH94_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HGH94_00890	COG0101	tRNA pseudouridine synthase activity
HGH94_00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HGH94_00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HGH94_00905	COG2226	methyltransferase
HGH94_00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
HGH94_00920	COG0489	protein tyrosine kinase activity
HGH94_00930	COG2194	sulfuric ester hydrolase activity
HGH94_00935	COG0726	polysaccharide deacetylase
HGH94_01020	COG0659	secondary active sulfate transmembrane transporter activity
HGH94_01025	COG0385	Bile acid
HGH94_01030	COG2819	hydrolase of the alpha beta superfamily
HGH94_01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HGH94_01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HGH94_01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HGH94_01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HGH94_01050	COG2207	Transcriptional regulator
HGH94_01055	COG3876	Protein conserved in bacteria
HGH94_01060	COG1472	Belongs to the glycosyl hydrolase 3 family
HGH94_01065	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HGH94_01070	COG1263	PTS System
HGH94_01070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HGH94_01075	COG1737	Transcriptional regulator
HGH94_01080	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HGH94_01085	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HGH94_01090	COG1683	Conserved Protein
HGH94_01120	COG1595	DNA-templated transcription, initiation
HGH94_01125	COG5662	AntiSigma factor
HGH94_01130	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HGH94_01135	COG4856	YbbR-like protein
HGH94_01140	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HGH94_01145	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HGH94_01155	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HGH94_01160	COG2169	Transcriptional regulator
HGH94_01165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HGH94_01170	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HGH94_01175	COG3002	Belongs to the UPF0753 family
HGH94_01180	COG0288	reversible hydration of carbon dioxide
HGH94_01190	COG5609	conserved protein (DUF2294)
HGH94_01195	COG0640	Transcriptional regulator
HGH94_01200	COG2814	Major facilitator Superfamily
HGH94_01210	COG0535	radical SAM domain protein
HGH94_01215	COG1266	CAAX protease self-immunity
HGH94_01220	COG1131	(ABC) transporter
HGH94_01230	COG1413	lyase activity
HGH94_01235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HGH94_01240	COG0596	Alpha beta hydrolase
HGH94_01245	COG0745	RESPONSE REGULATOR receiver
HGH94_01275	COG1113	amino acid transport
HGH94_01290	COG2602	Beta-lactamase
HGH94_01305	COG0531	amino acid
HGH94_01310	COG0584	glycerophosphoryl diester phosphodiesterase
HGH94_01325	COG0456	acetyltransferase
HGH94_01325	COG1846	Transcriptional regulator
HGH94_01330	COG2271	Major facilitator Superfamily
HGH94_01340	COG3409	Peptidoglycan-binding domain 1 protein
HGH94_01350	COG2207	Transcriptional regulator
HGH94_01350	COG1917	Cupin 2, conserved barrel domain protein
HGH94_01355	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HGH94_01360	COG3591	Belongs to the peptidase S1B family
HGH94_01370	COG0596	Alpha beta hydrolase
HGH94_01375	COG1183	phosphatidylcholine synthase activity
HGH94_01380	COG0586	Pfam SNARE associated Golgi protein
HGH94_01385	COG0688	phosphatidylethanolamine metabolic process
HGH94_01395	COG2312	Erythromycin esterase
HGH94_01405	COG1301	dicarboxylic acid transport
HGH94_01410	COG2190	(PTS) system
HGH94_01410	COG1263	PTS System
HGH94_01410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HGH94_01420	COG2188	Transcriptional regulator
HGH94_01430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HGH94_01435	COG0833	amino acid
HGH94_01440	COG2040	homocysteine
HGH94_01450	COG1115	amino acid carrier protein
HGH94_01455	COG2066	Belongs to the glutaminase family
HGH94_01460	COG4191	Histidine kinase
HGH94_01465	COG0784	Response regulator, receiver
HGH94_01470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HGH94_01475	COG1012	belongs to the aldehyde dehydrogenase family
HGH94_01485	COG4948	Mandelate Racemase Muconate Lactonizing
HGH94_01490	COG2186	Transcriptional regulator
HGH94_01510	COG0697	spore germination
HGH94_01515	COG0745	RESPONSE REGULATOR receiver
HGH94_01525	COG1131	(ABC) transporter
HGH94_01545	COG3773	Cell wall hydrolase
HGH94_01555	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGH94_01555	COG0072	phenylalanine-tRNA ligase activity
HGH94_01585	COG0531	amino acid
HGH94_01600	COG0137	argininosuccinate synthase activity
HGH94_01605	COG0626	cystathionine gamma-synthase activity
HGH94_01610	COG1279	arginine transmembrane transporter activity
HGH94_01615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HGH94_01630	COG3540	Alkaline phosphatase
HGH94_01635	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HGH94_01640	COG0805	protein transport
HGH94_01645	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HGH94_01650	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HGH94_01655	COG0477	Major facilitator Superfamily
HGH94_01660	COG1309	transcriptional regulator
HGH94_01665	COG0252	asparaginase activity
HGH94_01670	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HGH94_01675	COG1714	RDD family
HGH94_01680	COG1405	negative regulation of cell septum assembly
HGH94_01680	COG3012	SEC-C Motif Domain Protein
HGH94_01685	COG3290	protein histidine kinase activity
HGH94_01690	COG3279	Response regulator of the LytR AlgR family
HGH94_01695	COG4555	ABC transporter
HGH94_01700	COG1668	transmembrane transport
HGH94_01720	COG1595	DNA-templated transcription, initiation
HGH94_01725	COG1595	DNA-templated transcription, initiation
HGH94_01730	COG1876	peptidase activity
HGH94_01735	COG0457	Tetratricopeptide repeat
HGH94_01750	COG0803	Belongs to the bacterial solute-binding protein 9 family
HGH94_01755	COG1121	(ABC) transporter
HGH94_01760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HGH94_01765	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGH94_01770	COG2310	stress, protein
HGH94_01775	COG2310	stress, protein
HGH94_01780	COG2310	stress, protein
HGH94_01785	COG0861	Integral membrane protein TerC family
HGH94_01795	COG3853	Toxic anion resistance protein (TelA)
HGH94_01800	COG0477	Major facilitator Superfamily
HGH94_01805	COG2814	Major facilitator Superfamily
HGH94_01810	COG0640	Transcriptional regulator
HGH94_01815	COG4175	Glycine betaine
HGH94_01815	COG0517	IMP dehydrogenase activity
HGH94_01820	COG4176	ABC-type proline glycine betaine transport system permease component
HGH94_01825	COG2113	Glycine betaine
HGH94_01830	COG1473	amidohydrolase
HGH94_01835	COG1288	antiporter activity
HGH94_01855	COG0039	L-malate dehydrogenase activity
HGH94_01860	COG1620	l-lactate permease
HGH94_01865	COG2814	Major facilitator Superfamily
HGH94_01870	COG1846	Transcriptional regulator
HGH94_01875	COG1280	lysine exporter protein (LysE YggA)
HGH94_01880	COG3403	YqcI/YcgG family
HGH94_01895	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HGH94_01905	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HGH94_01910	COG2226	methyltransferase
HGH94_01915	COG0583	DNA-binding transcription factor activity
HGH94_01920	COG3458	cephalosporin-C deacetylase activity
HGH94_01925	COG3541	Predicted nucleotidyltransferase
HGH94_01930	COG0506	proline dehydrogenase activity
HGH94_01935	COG1012	belongs to the aldehyde dehydrogenase family
HGH94_01940	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HGH94_01945	COG2508	Transcriptional regulator
HGH94_01955	COG0701	Predicted permease
HGH94_01960	COG2267	carboxylic ester hydrolase activity
HGH94_01965	COG0492	ferredoxin-NADP+ reductase activity
HGH94_01970	COG1587	Uroporphyrinogen-III synthase
HGH94_01970	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HGH94_01975	COG2146	nitrite reductase [NAD(P)H] activity
HGH94_01980	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HGH94_01990	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HGH94_01995	COG2223	nitrite transmembrane transporter activity
HGH94_02000	COG1469	GTP cyclohydrolase I activity
HGH94_02005	COG1376	ErfK ybiS ycfS ynhG family protein
HGH94_02025	COG0765	amino acid transport
HGH94_02030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGH94_02040	COG1714	RDD family
HGH94_02060	COG3209	COG3209 Rhs family protein
HGH94_02070	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HGH94_02075	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HGH94_02080	COG1733	regulation of RNA biosynthetic process
HGH94_02085	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HGH94_02095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HGH94_02100	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HGH94_02105	COG2814	Major facilitator Superfamily
HGH94_02130	COG2364	Membrane
HGH94_02135	COG1126	abc transporter atp-binding protein
HGH94_02140	COG0765	amino acid transport
HGH94_02145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGH94_02150	COG0583	DNA-binding transcription factor activity
HGH94_02155	COG0163	prenyltransferase activity
HGH94_02160	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HGH94_02175	COG0596	Alpha beta hydrolase
HGH94_02180	COG3104	oligopeptide transport
HGH94_02185	COG5434	Belongs to the glycosyl hydrolase 28 family
HGH94_02195	COG0697	spore germination
HGH94_02205	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HGH94_02210	COG1136	(ABC) transporter
HGH94_02215	COG0577	efflux transmembrane transporter activity
HGH94_02220	COG0745	RESPONSE REGULATOR receiver
HGH94_02225	COG3850	Histidine kinase
HGH94_02225	COG5002	protein histidine kinase activity
HGH94_02230	COG0457	Tetratricopeptide repeat
HGH94_02250	COG0527	aspartate kinase activity
HGH94_02255	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HGH94_02260	COG4605	iron ion homeostasis
HGH94_02265	COG4604	ABC transporter, ATP-binding protein
HGH94_02270	COG4607	ABC-type enterochelin transport system periplasmic component
HGH94_02275	COG2814	Major facilitator Superfamily
HGH94_02280	COG1309	transcriptional regulator
HGH94_02285	COG0778	Nitroreductase
HGH94_02290	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HGH94_02295	COG0640	Transcriptional regulator
HGH94_02300	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HGH94_02305	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HGH94_02310	COG1012	belongs to the aldehyde dehydrogenase family
HGH94_02315	COG4975	Glucose uptake
HGH94_02320	COG1028	Short-chain dehydrogenase reductase Sdr
HGH94_02325	COG4549	nuclear export factor GLE1
HGH94_02330	COG1276	copper resistance
HGH94_02330	COG2372	response to copper ion
HGH94_02335	COG1349	DNA-binding transcription factor activity
HGH94_02345	COG2213	PTS system mannitol-specific
HGH94_02350	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGH94_02355	COG0246	Mannitol dehydrogenase
HGH94_02360	COG0473	3-isopropylmalate dehydrogenase activity
HGH94_02365	COG0681	Belongs to the peptidase S26 family
HGH94_02370	COG0412	Dienelactone hydrolase
HGH94_02375	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HGH94_02395	COG0561	phosphatase activity
HGH94_02400	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HGH94_02405	COG1914	H( )-stimulated, divalent metal cation uptake system
HGH94_02410	COG4336	lyase activity
HGH94_02415	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HGH94_02420	COG1984	allophanate hydrolase subunit 2
HGH94_02425	COG1414	Transcriptional regulator
HGH94_02430	COG2755	lipolytic protein G-D-S-L family
HGH94_02445	COG0768	penicillin binding
HGH94_02450	COG4989	oxidoreductase activity
HGH94_02455	COG3711	transcriptional antiterminator
HGH94_02460	COG0318	PFAM AMP-dependent synthetase and ligase
HGH94_02465	COG2226	methyltransferase
HGH94_02470	COG1028	Short-chain dehydrogenase reductase Sdr
HGH94_02475	COG1917	Cupin 2, conserved barrel domain protein
HGH94_02480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HGH94_02485	COG3871	stress protein (general stress protein 26)
HGH94_02495	COG2814	Major facilitator Superfamily
HGH94_02500	COG1522	sequence-specific DNA binding
HGH94_02505	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HGH94_02505	COG0551	DNA topoisomerase type I activity
HGH94_02510	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HGH94_02525	COG1215	transferase activity, transferring glycosyl groups
HGH94_02535	COG0531	amino acid
HGH94_02540	COG0494	nUDIX hydrolase
HGH94_02545	COG0028	Belongs to the TPP enzyme family
HGH94_02555	COG1914	H( )-stimulated, divalent metal cation uptake system
HGH94_02560	COG2261	transglycosylase associated protein
HGH94_02565	COG4876	unkown
HGH94_02570	COG2217	Heavy metal translocating P-type atpase
HGH94_02575	COG3729	General stress protein
HGH94_02580	COG0662	Cupin 2, conserved barrel domain protein
HGH94_02585	COG2329	Antibiotic biosynthesis monooxygenase
HGH94_02595	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HGH94_02600	COG3290	protein histidine kinase activity
HGH94_02605	COG4565	transcriptional regulatory protein
HGH94_02610	COG1301	dicarboxylic acid transport
HGH94_02615	COG0628	permease
HGH94_02620	COG1131	(ABC) transporter
HGH94_02625	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HGH94_02635	COG1960	acyl-CoA dehydrogenase activity
HGH94_02650	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HGH94_02655	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HGH94_02660	COG1181	Belongs to the D-alanine--D-alanine ligase family
HGH94_02665	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HGH94_02670	COG0513	Belongs to the DEAD box helicase family
HGH94_02675	COG3402	PFAM membrane-flanked domain
HGH94_02680	COG3428	Bacterial PH domain
HGH94_02685	COG0705	Rhomboid family
HGH94_02690	COG0736	holo-[acyl-carrier-protein] synthase activity
HGH94_02695	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HGH94_02700	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HGH94_02705	COG0864	Transcriptional regulator
HGH94_02710	COG2337	Toxic component of a toxin-antitoxin (TA) module
HGH94_02715	COG1366	Belongs to the anti-sigma-factor antagonist family
HGH94_02720	COG1366	Belongs to the anti-sigma-factor antagonist family
HGH94_02725	COG2172	sigma factor antagonist activity
HGH94_02730	COG2208	phosphoserine phosphatase activity
HGH94_02740	COG2172	sigma factor antagonist activity
HGH94_02745	COG1191	sigma factor activity
HGH94_02750	COG2208	phosphoserine phosphatase activity
HGH94_02755	COG2183	response to ionizing radiation
HGH94_02765	COG3091	SprT-like family
HGH94_02820	COG1476	TRANSCRIPTIONal
HGH94_02830	COG3239	Fatty acid desaturase
HGH94_02835	COG1278	Cold shock
HGH94_02850	COG1917	Cupin 2, conserved barrel domain protein
HGH94_02850	COG2207	Transcriptional regulator
HGH94_02855	COG0697	spore germination
HGH94_02860	COG3708	Transcriptional regulator
HGH94_02860	COG2207	Transcriptional regulator
HGH94_02865	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HGH94_02875	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HGH94_02885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGH94_02890	COG1309	transcriptional regulator
HGH94_02895	COG0697	spore germination
HGH94_02900	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HGH94_02905	COG2030	dehydratase
HGH94_02910	COG3545	Serine hydrolase
HGH94_02915	COG1733	regulation of RNA biosynthetic process
HGH94_02920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HGH94_02925	COG0640	Transcriptional regulator
HGH94_02930	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HGH94_02935	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HGH94_02940	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HGH94_02955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HGH94_02960	COG0640	Transcriptional regulator
HGH94_02965	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HGH94_02980	COG4585	Histidine kinase
HGH94_02985	COG2197	response regulator
HGH94_02990	COG2409	Drug exporters of the RND superfamily
HGH94_02995	COG1811	Na channel or pump
HGH94_03020	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HGH94_03025	COG0778	Nitroreductase
HGH94_03030	COG0346	lactoylglutathione lyase activity
HGH94_03035	COG2259	Doxx family
HGH94_03040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HGH94_03065	COG2323	membrane
HGH94_03070	COG0071	Belongs to the small heat shock protein (HSP20) family
HGH94_03085	COG1309	transcriptional regulator
HGH94_03095	COG0456	acetyltransferase
HGH94_03105	COG1113	amino acid transport
HGH94_03110	COG2318	DinB family
HGH94_03115	COG1846	Transcriptional regulator
HGH94_03120	COG1033	growth of symbiont in host cell
HGH94_03120	COG2409	Drug exporters of the RND superfamily
HGH94_03125	COG0778	Nitroreductase
HGH94_03130	COG1846	Transcriptional regulator
HGH94_03135	COG2814	Major facilitator Superfamily
HGH94_03145	COG1802	Transcriptional regulator
HGH94_03150	COG3858	chitin binding
HGH94_03150	COG1388	LysM domain
HGH94_03155	COG1819	glycosyl
HGH94_03165	COG1785	Belongs to the alkaline phosphatase family
HGH94_03170	COG5646	InterPro IPR014922
HGH94_03180	COG0454	-acetyltransferase
HGH94_03185	COG1078	dGTPase activity
HGH94_03190	COG1388	LysM domain
HGH94_03195	COG2814	Major facilitator Superfamily
HGH94_03200	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HGH94_03205	COG1447	Phosphotransferase system cellobiose-specific component IIA
HGH94_03210	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HGH94_03215	COG2723	6-phospho-beta-galactosidase activity
HGH94_03220	COG2188	Transcriptional regulator
HGH94_03230	COG1482	cell wall glycoprotein biosynthetic process
HGH94_03280	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HGH94_03285	COG0802	atpase or kinase
HGH94_03290	COG1214	PFAM Peptidase M22, glycoprotease
HGH94_03295	COG0456	acetyltransferase
HGH94_03300	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HGH94_03305	COG0488	(ABC) transporter
HGH94_03310	COG0315	cyclic pyranopterin monophosphate synthase activity
HGH94_03315	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HGH94_03320	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HGH94_03325	COG0805	protein transport
HGH94_03335	COG1266	CAAX protease self-immunity
HGH94_03365	COG5444	nuclease activity
HGH94_03375	COG2322	membrane
HGH94_03400	COG0457	Tetratricopeptide repeat
HGH94_03405	COG1063	alcohol dehydrogenase
HGH94_03410	COG2211	Major facilitator Superfamily
HGH94_03415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGH94_03420	COG1842	Phage shock protein A
HGH94_03425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HGH94_03430	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HGH94_03435	COG4260	virion core protein, lumpy skin disease virus
HGH94_03445	COG2814	Major facilitator Superfamily
HGH94_03450	COG1063	alcohol dehydrogenase
HGH94_03455	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HGH94_03460	COG0823	Involved in the tonB-independent uptake of proteins
HGH94_03480	COG2267	carboxylic ester hydrolase activity
HGH94_03490	COG2132	Multicopper oxidase
HGH94_03495	COG1113	amino acid transport
HGH94_03505	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HGH94_03515	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HGH94_03520	COG1305	Transglutaminase-like
HGH94_03545	COG2252	PERMEase
HGH94_03560	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HGH94_03570	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HGH94_03575	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HGH94_03580	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HGH94_03585	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HGH94_03590	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HGH94_03595	COG0047	phosphoribosylformylglycinamidine synthase activity
HGH94_03600	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HGH94_03605	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HGH94_03610	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HGH94_03615	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HGH94_03620	COG0138	bifunctional purine biosynthesis protein purh
HGH94_03625	COG0151	Belongs to the GarS family
HGH94_03630	COG1522	sequence-specific DNA binding
HGH94_03645	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HGH94_03650	COG1470	cell adhesion involved in biofilm formation
HGH94_03655	COG4496	protein, YerC YecD
HGH94_03660	COG0069	glutamate synthase activity
HGH94_03665	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HGH94_03670	COG0210	DNA helicase
HGH94_03675	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HGH94_03680	COG4851	CamS sex pheromone cAM373 precursor
HGH94_03690	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HGH94_03695	COG1285	pathogenesis
HGH94_03700	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HGH94_03705	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HGH94_03710	COG0154	amidase activity
HGH94_03715	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HGH94_03720	COG1309	transcriptional regulator
HGH94_03730	COG1597	lipid kinase activity
HGH94_03745	COG0457	Tetratricopeptide repeat
HGH94_03765	COG5444	nuclease activity
HGH94_03775	COG0457	Tetratricopeptide repeat
HGH94_03785	COG0217	transcriptional regulatory protein
HGH94_03795	COG1309	transcriptional regulator
HGH94_03810	COG3546	catalase activity
HGH94_03815	COG0454	-acetyltransferase
HGH94_03825	COG5578	integral membrane protein
HGH94_03830	COG2972	Histidine kinase
HGH94_03835	COG4753	response regulator
HGH94_03835	COG2207	Transcriptional regulator
HGH94_03840	COG1653	transport
HGH94_03845	COG1175	transmembrane transport
HGH94_03855	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HGH94_03860	COG2207	Transcriptional regulator
HGH94_03865	COG2755	lipolytic protein G-D-S-L family
HGH94_03875	COG5578	integral membrane protein
HGH94_03880	COG3401	FG-GAP repeat protein
HGH94_03885	COG3401	FG-GAP repeat protein
HGH94_03905	COG1653	transport
HGH94_03910	COG4209	transmembrane transport
HGH94_03915	COG0395	ABC-type sugar transport system, permease component
HGH94_03920	COG1486	melibiose metabolic process
HGH94_03925	COG2323	membrane
HGH94_03930	COG2329	Antibiotic biosynthesis monooxygenase
HGH94_03950	COG5583	Uncharacterized small protein (DUF2292)
HGH94_03955	COG0670	Belongs to the BI1 family
HGH94_03960	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HGH94_03980	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HGH94_03980	COG2124	cytochrome p450
HGH94_03985	COG1368	sulfuric ester hydrolase activity
HGH94_03990	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HGH94_03995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HGH94_04000	COG1442	glycosyl transferase family 8
HGH94_04005	COG1216	Glycosyl transferase, family 2
HGH94_04010	COG1442	glycosyl transferase family 8
HGH94_04015	COG2223	nitrite transmembrane transporter activity
HGH94_04025	COG0531	amino acid
HGH94_04035	COG0840	transmembrane signaling receptor activity
HGH94_04040	COG0488	(ABC) transporter
HGH94_04050	COG0789	Transcriptional regulator
HGH94_04055	COG2814	Major facilitator Superfamily
HGH94_04065	COG0488	(ABC) transporter
HGH94_04070	COG0513	Belongs to the DEAD box helicase family
HGH94_04085	COG2130	NADP-dependent
HGH94_04090	COG1120	ATPase activity
HGH94_04095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HGH94_04100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HGH94_04120	COG3866	Pectate lyase
HGH94_04125	COG0471	metal ion transport
HGH94_04130	COG3290	protein histidine kinase activity
HGH94_04135	COG4565	transcriptional regulatory protein
HGH94_04140	COG3181	Tripartite tricarboxylate transporter family receptor
HGH94_04145	COG2851	Citrate transporter
HGH94_04150	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGH94_04160	COG1254	Belongs to the acylphosphatase family
HGH94_04165	COG2258	MOSC domain
HGH94_04185	COG0024	Methionine aminopeptidase
HGH94_04190	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HGH94_04190	COG1263	PTS System
HGH94_04195	COG1368	sulfuric ester hydrolase activity
HGH94_04220	COG1263	PTS System
HGH94_04220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HGH94_04230	COG2188	Transcriptional regulator
HGH94_04235	COG0778	Nitroreductase
HGH94_04240	COG0737	Belongs to the 5'-nucleotidase family
HGH94_04245	COG0693	protein deglycase activity
HGH94_04250	COG2814	Major facilitator Superfamily
HGH94_04255	COG4840	Belongs to the UPF0435 family
HGH94_04260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HGH94_04265	COG4980	gas vesicle protein
HGH94_04270	COG1295	ribonuclease BN
HGH94_04275	COG0477	Major facilitator Superfamily
HGH94_04280	COG0387	Pfam Sodium calcium exchanger
HGH94_04290	COG0668	transmembrane transport
HGH94_04295	COG0535	radical SAM domain protein
HGH94_04305	COG0726	polysaccharide deacetylase
HGH94_04310	COG2084	Dehydrogenase
HGH94_04315	COG0598	Magnesium transport protein CorA
HGH94_04320	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HGH94_04325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HGH94_04335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HGH94_04340	COG4637	Psort location Cytoplasmic, score
HGH94_04350	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HGH94_04355	COG0022	dehydrogenase e1 component
HGH94_04360	COG0508	dehydrogenase complex catalyzes the overall conversion of
HGH94_04365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HGH94_04370	COG3284	Transcriptional regulator
HGH94_04380	COG1742	UPF0060 membrane protein
HGH94_04400	COG4842	Belongs to the WXG100 family
HGH94_04410	COG1737	Transcriptional regulator
HGH94_04415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HGH94_04415	COG1263	PTS System
HGH94_04420	COG1132	(ABC) transporter
HGH94_04425	COG1132	(ABC) transporter
HGH94_04430	COG2259	Doxx family
HGH94_04435	COG2514	catechol 2,3-dioxygenase activity
HGH94_04440	COG4977	sequence-specific DNA binding
HGH94_04440	COG1917	Cupin 2, conserved barrel domain protein
HGH94_04445	COG2814	Major facilitator Superfamily
HGH94_04450	COG1082	Xylose isomerase domain protein TIM barrel
HGH94_04455	COG0673	inositol 2-dehydrogenase activity
HGH94_04460	COG4585	Histidine kinase
HGH94_04465	COG2197	response regulator
HGH94_04470	COG1131	(ABC) transporter
HGH94_04475	COG0842	Transport permease protein
HGH94_04475	COG1511	domain protein
HGH94_04480	COG0842	Transport permease protein
HGH94_04490	COG1695	Transcriptional regulator
HGH94_04495	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HGH94_04505	COG2318	DinB family
HGH94_04510	COG2814	Major facilitator Superfamily
HGH94_04515	COG1846	Transcriptional regulator
HGH94_04520	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HGH94_04520	COG0392	lysyltransferase activity
HGH94_04525	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HGH94_04530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HGH94_04535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HGH94_04540	COG0384	phenazine biosynthesis protein PhzF
HGH94_04545	COG0778	Nitroreductase
HGH94_04560	COG1090	epimerase
HGH94_04565	COG2137	regulation of response to DNA damage stimulus
HGH94_04575	COG2814	Major facilitator Superfamily
HGH94_04595	COG3103	Sh3 type 3 domain protein
HGH94_04600	COG5658	integral membrane protein
HGH94_04605	COG0596	Alpha beta hydrolase
HGH94_04610	COG0463	Glycosyl transferase, family 2
HGH94_04615	COG4485	Bacterial membrane protein, YfhO
HGH94_04620	COG1988	membrane-bound metal-dependent
HGH94_04625	COG1194	a g-specific adenine glycosylase
HGH94_04635	COG1028	Short-chain dehydrogenase reductase Sdr
HGH94_04650	COG3557	Belongs to the UPF0374 family
HGH94_04665	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HGH94_04670	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HGH94_04675	COG0735	belongs to the Fur family
HGH94_04800	COG5577	PFAM Coat F domain
HGH94_04805	COG3340	Belongs to the peptidase S51 family
HGH94_04810	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HGH94_04815	COG0277	FAD linked oxidase domain protein
HGH94_04830	COG1116	anion transmembrane transporter activity
HGH94_04835	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HGH94_04845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGH94_04855	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HGH94_04865	COG1476	TRANSCRIPTIONal
HGH94_04875	COG3382	B3 4 domain protein
HGH94_04880	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HGH94_04890	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HGH94_04895	COG0789	Transcriptional regulator
HGH94_04900	COG1664	Polymer-forming cytoskeletal
HGH94_04905	COG2766	serine protein kinase
HGH94_04910	COG2718	Belongs to the UPF0229 family
HGH94_04915	COG1846	Transcriptional regulator
HGH94_04920	COG1566	PFAM secretion protein HlyD family protein
HGH94_04925	COG2814	Major facilitator Superfamily
HGH94_04930	COG0655	NAD(P)H dehydrogenase (quinone) activity
HGH94_04950	COG1725	Transcriptional regulator
HGH94_04955	COG1131	(ABC) transporter
HGH94_04960	COG1131	(ABC) transporter
HGH94_04965	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HGH94_04970	COG1278	Cold shock
HGH94_04975	COG1464	Belongs to the NlpA lipoprotein family
HGH94_04980	COG3706	GGDEF domain
HGH94_04985	COG1823	symporter activity
HGH94_05010	COG4085	toxin activity
HGH94_05010	COG1525	nuclease
HGH94_05010	COG0737	Belongs to the 5'-nucleotidase family
HGH94_05015	COG3764	Sortase (surface protein transpeptidase)
HGH94_05020	COG0564	pseudouridine synthase activity
HGH94_05030	COG0517	IMP dehydrogenase activity
HGH94_05035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HGH94_05040	COG3153	acetyltransferase
HGH94_05040	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HGH94_05045	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HGH94_05050	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HGH94_05055	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HGH94_05060	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HGH94_05065	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HGH94_05070	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HGH94_05075	COG2203	Gaf domain
HGH94_05075	COG4585	Histidine kinase
HGH94_05080	COG2197	response regulator
HGH94_05085	COG0431	NADPH-dependent FMN reductase
HGH94_05105	COG1959	2 iron, 2 sulfur cluster binding
HGH94_05110	COG0668	transmembrane transport
HGH94_05115	COG2719	SpoVR family
HGH94_05120	COG1785	Belongs to the alkaline phosphatase family
HGH94_05125	COG0791	NLP P60 protein
HGH94_05125	COG1388	LysM domain
HGH94_05130	COG0583	DNA-binding transcription factor activity
HGH94_05140	COG1028	Short-chain dehydrogenase reductase Sdr
HGH94_05145	COG0531	amino acid
HGH94_05150	COG0733	neurotransmitter:sodium symporter activity
HGH94_05155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HGH94_05160	COG0456	acetyltransferase
HGH94_05175	COG1595	DNA-templated transcription, initiation
HGH94_05180	COG0667	Aldo Keto reductase
HGH94_05185	COG0204	Acyl-transferase
HGH94_05190	COG1253	flavin adenine dinucleotide binding
HGH94_05195	COG0789	Transcriptional regulator
HGH94_05205	COG1253	flavin adenine dinucleotide binding
HGH94_05210	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HGH94_05215	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HGH94_05220	COG0584	glycerophosphoryl diester phosphodiesterase
HGH94_05230	COG0668	transmembrane transport
HGH94_05235	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HGH94_05240	COG0726	polysaccharide deacetylase
HGH94_05245	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HGH94_05250	COG1757	Na H antiporter
HGH94_05255	COG0589	response to stress
HGH94_05265	COG1132	(ABC) transporter
HGH94_05270	COG1132	(ABC) transporter
HGH94_05275	COG0702	epimerase
HGH94_05295	COG0189	ligase activity
HGH94_05300	COG0189	ligase activity
HGH94_05305	COG4399	Belongs to the UPF0754 family
HGH94_05310	COG3679	Belongs to the UPF0342 family
HGH94_05320	COG0561	phosphatase activity
HGH94_05325	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HGH94_05330	COG0475	glutathione-regulated potassium exporter activity
HGH94_05335	COG0490	domain, Protein
HGH94_05345	COG1024	Enoyl-CoA hydratase
HGH94_05355	COG4152	abc transporter atp-binding protein
HGH94_05365	COG0420	3'-5' exonuclease activity
HGH94_05370	COG4717	serine-type aminopeptidase activity
HGH94_05375	COG3481	metal-dependent phosphohydrolase, HD sub domain
HGH94_05385	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HGH94_05415	COG1846	Transcriptional regulator
HGH94_05420	COG4980	gas vesicle protein
HGH94_05440	COG0537	adenosine 5'-monophosphoramidase activity
HGH94_05445	COG1131	(ABC) transporter
HGH94_05450	COG4473	ABC transporter
HGH94_05460	COG1473	amidohydrolase
HGH94_05475	COG2329	Antibiotic biosynthesis monooxygenase
HGH94_05485	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HGH94_05500	COG1309	transcriptional regulator
HGH94_05515	COG4377	Putative membrane peptidase family (DUF2324)
HGH94_05525	COG1363	Peptidase, m42
HGH94_05530	COG4405	Protein conserved in bacteria
HGH94_05535	COG1301	dicarboxylic acid transport
HGH94_05545	COG1234	tRNA 3'-trailer cleavage
HGH94_05550	COG0095	Lipoate-protein ligase
HGH94_05555	COG0702	epimerase
HGH94_05560	COG0318	PFAM AMP-dependent synthetase and ligase
HGH94_05570	COG0501	Belongs to the peptidase M48B family
HGH94_05575	COG1404	Belongs to the peptidase S8 family
HGH94_05580	COG0456	acetyltransferase
HGH94_05585	COG0604	alcohol dehydrogenase
HGH94_05590	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HGH94_05595	COG0406	alpha-ribazole phosphatase activity
HGH94_05600	COG0183	Belongs to the thiolase family
HGH94_05605	COG0318	PFAM AMP-dependent synthetase and ligase
HGH94_05610	COG1268	BioY protein
HGH94_05615	COG0840	transmembrane signaling receptor activity
HGH94_05635	COG4903	ComK protein
HGH94_05640	COG1028	Short-chain dehydrogenase reductase Sdr
HGH94_05650	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HGH94_05665	COG0398	Pfam SNARE associated Golgi protein
HGH94_05670	COG0681	Belongs to the peptidase S26 family
HGH94_05675	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HGH94_05680	COG1846	Transcriptional regulator
HGH94_05690	COG0673	inositol 2-dehydrogenase activity
HGH94_05695	COG0561	phosphatase activity
HGH94_05705	COG1609	Transcriptional regulator
HGH94_05710	COG3180	Ammonia monooxygenase
HGH94_05715	COG0477	Major facilitator Superfamily
HGH94_05715	COG2814	Major facilitator Superfamily
HGH94_05720	COG4533	DNA binding
HGH94_05730	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HGH94_05735	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HGH94_05745	COG0420	3'-5' exonuclease activity
HGH94_05750	COG0419	ATPase involved in DNA repair
HGH94_05755	COG1403	HNH endonuclease
HGH94_05795	COG5337	Spore coat protein CotH
HGH94_05800	COG0179	Fumarylacetoacetate (FAA) hydrolase
HGH94_05820	COG0367	asparagine synthase
HGH94_05825	COG1562	ergosterol biosynthetic process
HGH94_05830	COG0534	Mate efflux family protein
HGH94_05835	COG1917	Cupin 2, conserved barrel domain protein
HGH94_05835	COG2207	Transcriptional regulator
HGH94_05840	COG1609	Transcriptional regulator
HGH94_05845	COG0673	inositol 2-dehydrogenase activity
HGH94_05850	COG2318	DinB family
HGH94_05855	COG1279	arginine transmembrane transporter activity
HGH94_05860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HGH94_05865	COG1357	PFAM Pentapeptide repeats (8 copies)
HGH94_05870	COG2267	carboxylic ester hydrolase activity
HGH94_05875	COG0529	Catalyzes the synthesis of activated sulfate
HGH94_05895	COG1809	phosphosulfolactate synthase activity
HGH94_05900	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HGH94_05905	COG4948	Mandelate Racemase Muconate Lactonizing
HGH94_05960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HGH94_05985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HGH94_05990	COG2323	membrane
HGH94_06000	COG0454	-acetyltransferase
HGH94_06005	COG2153	protein acetylation
HGH94_06010	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HGH94_06010	COG0646	methionine synthase
HGH94_06015	COG1666	GTP binding
HGH94_06020	COG2996	Protein conserved in bacteria
HGH94_06040	COG1695	Transcriptional regulator
HGH94_06060	COG1307	EDD domain protein, DegV family
HGH94_06065	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HGH94_06085	COG0561	phosphatase activity
HGH94_06090	COG1073	alpha beta
HGH94_06095	COG2151	metal-sulfur cluster biosynthetic enzyme
HGH94_06105	COG0277	FAD linked oxidase domain protein
HGH94_06110	COG2271	Major facilitator Superfamily
HGH94_06115	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HGH94_06120	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HGH94_06130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HGH94_06135	COG0505	Belongs to the CarA family
HGH94_06140	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HGH94_06145	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HGH94_06160	COG2267	carboxylic ester hydrolase activity
HGH94_06170	COG1744	ABC transporter substrate-binding protein PnrA-like
HGH94_06185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HGH94_06190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HGH94_06195	COG5504	Zn-dependent protease
HGH94_06200	COG0444	Belongs to the ABC transporter superfamily
HGH94_06215	COG0601	transmembrane transport
HGH94_06220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGH94_06230	COG0180	Tryptophanyl-tRNA synthetase
HGH94_06235	COG4166	transmembrane transport
HGH94_06240	COG0601	transmembrane transport
HGH94_06245	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGH94_06250	COG0444	Belongs to the ABC transporter superfamily
HGH94_06255	COG4608	Belongs to the ABC transporter superfamily
HGH94_06260	COG2814	Major facilitator Superfamily
HGH94_06265	COG0456	acetyltransferase
HGH94_06270	COG1393	Belongs to the ArsC family
HGH94_06275	COG0861	Integral membrane protein TerC family
HGH94_06285	COG4862	establishment of competence for transformation
HGH94_06300	COG1164	Oligoendopeptidase f
HGH94_06315	COG2346	COG2346, Truncated hemoglobins
HGH94_06320	COG0741	lytic transglycosylase activity
HGH94_06325	COG4116	CYTH
HGH94_06335	COG2357	RelA SpoT domain protein
HGH94_06340	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HGH94_06345	COG0564	pseudouridine synthase activity
HGH94_06350	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HGH94_06355	COG0475	glutathione-regulated potassium exporter activity
HGH94_06355	COG0569	domain protein
HGH94_06360	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HGH94_06365	COG0352	thiamine-phosphate diphosphorylase activity
HGH94_06370	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGH94_06375	COG2104	thiamine diphosphate biosynthetic process
HGH94_06380	COG2022	thiamine diphosphate biosynthetic process
HGH94_06385	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HGH94_06390	COG0351	phosphomethylpyrimidine kinase
HGH94_06395	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HGH94_06450	COG0210	DNA helicase
HGH94_06460	COG2153	protein acetylation
HGH94_06465	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HGH94_06470	COG2382	esterase
HGH94_06475	COG0626	cystathionine gamma-synthase activity
HGH94_06480	COG0626	cystathionine gamma-synthase activity
HGH94_06485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HGH94_06490	COG5505	Protein of unknown function (DUF819)
HGH94_06515	COG5444	nuclease activity
HGH94_06565	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HGH94_06570	COG1028	Short-chain dehydrogenase reductase Sdr
HGH94_06580	COG3711	transcriptional antiterminator
HGH94_06580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGH94_06585	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HGH94_06585	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HGH94_06585	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGH94_06590	COG1482	cell wall glycoprotein biosynthetic process
HGH94_06605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HGH94_06615	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HGH94_06630	COG0109	protoheme IX farnesyltransferase activity
HGH94_06640	COG0726	polysaccharide deacetylase
HGH94_06645	COG2801	Transposase and inactivated derivatives
HGH94_06675	COG2205	protein histidine kinase activity
HGH94_06690	COG2427	Protein of unknown function (DUF1641)
HGH94_06710	COG2124	cytochrome p450
HGH94_06715	COG1819	glycosyl
HGH94_06725	COG1587	Uroporphyrinogen-III synthase
HGH94_06730	COG0390	transport system, permease component
HGH94_06735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HGH94_06740	COG0697	spore germination
HGH94_06745	COG4297	protein containing double-stranded beta helix domain
HGH94_06755	COG1252	NADH dehydrogenase
HGH94_06760	COG1904	glucuronate isomerase
HGH94_06770	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HGH94_06775	COG1063	alcohol dehydrogenase
HGH94_06780	COG1312	Catalyzes the dehydration of D-mannonate
HGH94_06785	COG1028	Short-chain dehydrogenase reductase Sdr
HGH94_06790	COG2271	Major facilitator Superfamily
HGH94_06795	COG1609	Transcriptional regulator
HGH94_06800	COG0246	Mannitol dehydrogenase
HGH94_06810	COG0730	response to heat
HGH94_06815	COG2318	DinB family
HGH94_06820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HGH94_06825	COG0457	Tetratricopeptide repeat
HGH94_06835	COG2350	Protein conserved in bacteria
HGH94_06840	COG5632	N-Acetylmuramoyl-L-alanine amidase
HGH94_06840	COG3409	Peptidoglycan-binding domain 1 protein
HGH94_06840	COG1388	LysM domain
HGH94_06850	COG4195	phage-related replication protein
HGH94_06855	COG3546	catalase activity
HGH94_06860	COG2856	Zn peptidase
HGH94_06865	COG1396	sequence-specific DNA binding
HGH94_06875	COG1522	sequence-specific DNA binding
HGH94_06900	COG1595	DNA-templated transcription, initiation
HGH94_06905	COG3728	DNA packaging
HGH94_06905	COG5484	DNA packaging
HGH94_06910	COG1783	phage Terminase large subunit
HGH94_06915	COG5518	Phage portal protein
HGH94_06920	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HGH94_06925	COG4653	Phage capsid family
HGH94_06980	COG1652	LysM domain
HGH94_06985	COG4193	domain, Protein
HGH94_06995	COG3628	GPW Gp25 family protein
HGH94_07000	COG3299	homolog of phage Mu protein gp47
HGH94_07005	COG3778	Protein conserved in bacteria
HGH94_07040	COG5632	N-Acetylmuramoyl-L-alanine amidase
HGH94_07040	COG3409	Peptidoglycan-binding domain 1 protein
HGH94_07065	COG1392	Phosphate transport regulator
HGH94_07070	COG0531	amino acid
HGH94_07075	COG0346	lactoylglutathione lyase activity
HGH94_07080	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HGH94_07085	COG0463	Glycosyl transferase, family 2
HGH94_07095	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HGH94_07100	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HGH94_07105	COG2362	D-Aminopeptidase
HGH94_07110	COG0601	transmembrane transport
HGH94_07115	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HGH94_07120	COG0444	Belongs to the ABC transporter superfamily
HGH94_07125	COG4166	transmembrane transport
HGH94_07130	COG1619	proteins homologs of microcin C7 resistance protein MccF
HGH94_07135	COG4948	Mandelate Racemase Muconate Lactonizing
HGH94_07145	COG4608	Belongs to the ABC transporter superfamily
HGH94_07150	COG2706	6-phosphogluconolactonase activity
HGH94_07155	COG1834	amidinotransferase
HGH94_07160	COG1607	acyl-coa hydrolase
HGH94_07165	COG1017	nitric oxide dioxygenase activity
HGH94_07165	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HGH94_07175	COG2323	membrane
HGH94_07180	COG2318	DinB family
HGH94_07185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HGH94_07190	COG2076	Multidrug Resistance protein
HGH94_07195	COG2076	Multidrug Resistance protein
HGH94_07200	COG0788	formyltetrahydrofolate deformylase activity
HGH94_07205	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HGH94_07210	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HGH94_07215	COG1764	response to oxidative stress
HGH94_07220	COG1846	Transcriptional regulator
HGH94_07225	COG1764	response to oxidative stress
HGH94_07230	COG0590	tRNA wobble adenosine to inosine editing
HGH94_07240	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HGH94_07245	COG1404	Belongs to the peptidase S8 family
HGH94_07250	COG1366	Belongs to the anti-sigma-factor antagonist family
HGH94_07255	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HGH94_07260	COG1122	ATPase activity
HGH94_07265	COG4721	ABC-type cobalt transport system, permease component
HGH94_07275	COG0745	RESPONSE REGULATOR receiver
HGH94_07280	COG5002	protein histidine kinase activity
HGH94_07280	COG3850	Histidine kinase
HGH94_07285	COG3212	peptidase
HGH94_07290	COG3212	peptidase
HGH94_07300	COG2239	Acts as a magnesium transporter
HGH94_07305	COG0789	Transcriptional regulator
HGH94_07320	COG1846	Transcriptional regulator
HGH94_07330	COG0726	polysaccharide deacetylase
HGH94_07345	COG0463	Glycosyl transferase, family 2
HGH94_07350	COG3285	dna ligase
HGH94_07350	COG1793	dna ligase
HGH94_07355	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HGH94_07365	COG0586	Pfam SNARE associated Golgi protein
HGH94_07370	COG0861	Integral membrane protein TerC family
HGH94_07375	COG1191	sigma factor activity
HGH94_07395	COG0501	Belongs to the peptidase M48B family
HGH94_07400	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HGH94_07425	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HGH94_07435	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HGH94_07440	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HGH94_07445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HGH94_07450	COG0436	Aminotransferase
HGH94_07455	COG1850	ribulose-bisphosphate carboxylase activity
HGH94_07460	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HGH94_07465	COG0235	Class ii aldolase
HGH94_07475	COG3339	Conserved Protein
HGH94_07490	COG3852	Histidine kinase
HGH94_07495	COG1846	Transcriptional regulator
HGH94_07500	COG1360	Flagellar Motor Protein
HGH94_07505	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HGH94_07510	COG0542	response to heat
HGH94_07515	COG3949	Membrane
HGH94_07520	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HGH94_07525	COG0720	synthase
HGH94_07530	COG0602	queuosine metabolic process
HGH94_07535	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HGH94_07600	COG0582	viral genome integration into host DNA
HGH94_07615	COG4873	Protein conserved in bacteria
HGH94_07625	COG3773	Cell wall hydrolase
HGH94_07630	COG2244	polysaccharide biosynthetic process
HGH94_07635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HGH94_07650	COG0006	proline dipeptidase activity
HGH94_07660	COG3711	transcriptional antiterminator
HGH94_07665	COG2190	(PTS) system
HGH94_07665	COG1263	PTS System
HGH94_07665	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HGH94_07670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGH94_07675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HGH94_07685	COG1533	DNA photolyase activity
HGH94_07690	COG0456	acetyltransferase
HGH94_07695	COG0840	transmembrane signaling receptor activity
HGH94_07700	COG2084	Dehydrogenase
HGH94_07705	COG3328	transposase activity
HGH94_07710	COG2340	Cysteine-rich secretory protein family
HGH94_07715	COG0768	penicillin binding
HGH94_07720	COG4191	Histidine kinase
HGH94_07725	COG0436	Aminotransferase
HGH94_07735	COG0835	chemotaxis
HGH94_07735	COG0784	Response regulator, receiver
HGH94_07745	COG2814	Major facilitator Superfamily
HGH94_07750	COG1376	ErfK ybiS ycfS ynhG family protein
HGH94_07755	COG1408	metallophosphoesterase
HGH94_07765	COG3409	Peptidoglycan-binding domain 1 protein
HGH94_07775	COG2200	EAL domain
HGH94_07780	COG4703	Protein of unknown function (DUF1797)
HGH94_07785	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HGH94_07795	COG0517	IMP dehydrogenase activity
HGH94_07800	COG0583	DNA-binding transcription factor activity
HGH94_07805	COG0716	FMN binding
HGH94_07815	COG0716	FMN binding
HGH94_07820	COG2171	N-acyltransferase activity
HGH94_07825	COG1473	amidohydrolase
HGH94_07840	COG0450	alkyl hydroperoxide reductase
HGH94_07845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HGH94_07865	COG0746	molybdenum cofactor guanylyltransferase activity
HGH94_07870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HGH94_07875	COG0303	'Molybdopterin
HGH94_07880	COG1763	Mo-molybdopterin cofactor biosynthetic process
HGH94_07885	COG0314	molybdopterin synthase activity
HGH94_07890	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HGH94_07895	COG1132	(ABC) transporter
HGH94_07900	COG1132	(ABC) transporter
HGH94_07910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGH94_07915	COG1136	(ABC) transporter
HGH94_07920	COG0577	efflux transmembrane transporter activity
HGH94_07925	COG1349	DNA-binding transcription factor activity
HGH94_07930	COG1105	Belongs to the carbohydrate kinase PfkB family
HGH94_07935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGH94_07935	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HGH94_07935	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HGH94_07940	COG0681	Belongs to the peptidase S26 family
HGH94_07955	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HGH94_07960	COG2309	aminopeptidase activity
HGH94_07970	COG1077	Cell shape determining protein MreB Mrl
HGH94_07975	COG2002	toxin-antitoxin pair type II binding
HGH94_07980	COG3852	Histidine kinase
HGH94_07985	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HGH94_07985	COG2105	PFAM AIG2 family protein
HGH94_07990	COG0569	domain protein
HGH94_07995	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HGH94_08000	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HGH94_08010	COG0561	phosphatase activity
HGH94_08015	COG0242	peptide deformylase activity
HGH94_08025	COG0497	DNA recombination
HGH94_08035	COG0022	dehydrogenase e1 component
HGH94_08040	COG0508	dehydrogenase complex catalyzes the overall conversion of
HGH94_08045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HGH94_08050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HGH94_08060	COG1982	Orn Lys Arg decarboxylase major
HGH94_08065	COG4476	Belongs to the UPF0223 family
HGH94_08070	COG4493	Belongs to the UPF0637 family
HGH94_08080	COG0483	inositol monophosphate 1-phosphatase activity
HGH94_08090	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HGH94_08115	COG1595	DNA-templated transcription, initiation
HGH94_08145	COG4896	Protein conserved in bacteria
HGH94_08155	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HGH94_08160	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HGH94_08165	COG2066	Belongs to the glutaminase family
HGH94_08170	COG4838	Belongs to the UPF0358 family
HGH94_08175	COG0772	Belongs to the SEDS family
HGH94_08180	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HGH94_08185	COG1612	heme a metabolic process
HGH94_08190	COG0109	protoheme IX farnesyltransferase activity
HGH94_08195	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HGH94_08195	COG2010	Cytochrome c
HGH94_08200	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HGH94_08205	COG1845	cytochrome c oxidase, subunit III
HGH94_08210	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HGH94_08215	COG3336	cytochrome c oxidase
HGH94_08225	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HGH94_08230	COG2340	Cysteine-rich secretory protein family
HGH94_08245	COG3679	Belongs to the UPF0342 family
HGH94_08250	COG4471	UPF0298 protein
HGH94_08255	COG0742	ribosomal rna small subunit methyltransferase
HGH94_08260	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HGH94_08270	COG1752	Esterase of the alpha-beta hydrolase superfamily
HGH94_08275	COG3480	Lon protease (S16) C-terminal proteolytic domain
HGH94_08280	COG1323	Belongs to the UPF0348 family
HGH94_08290	COG1399	metal-binding, possibly nucleic acid-binding protein
HGH94_08305	COG0454	-acetyltransferase
HGH94_08310	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HGH94_08315	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HGH94_08320	COG2001	Belongs to the MraZ family
HGH94_08325	COG0275	rRNA processing
HGH94_08330	COG4839	cell division protein FtsL
HGH94_08340	COG0768	penicillin binding
HGH94_08345	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HGH94_08350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HGH94_08355	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HGH94_08360	COG0772	Belongs to the SEDS family
HGH94_08365	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HGH94_08370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HGH94_08375	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HGH94_08380	COG3879	Bacterial protein of unknown function (DUF881)
HGH94_08385	COG3879	Bacterial protein of unknown function (DUF881)
HGH94_08390	COG3856	small basic protein
HGH94_08395	COG0849	cell division
HGH94_08400	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HGH94_08405	COG1404	Belongs to the peptidase S8 family
HGH94_08405	COG4412	M6 family metalloprotease domain protein
HGH94_08415	COG1191	sigma factor activity
HGH94_08420	COG1191	sigma factor activity
HGH94_08430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HGH94_08435	COG1873	PFAM PRC-barrel domain
HGH94_08445	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HGH94_08450	COG1799	cell septum assembly
HGH94_08455	COG0762	integral membrane protein
HGH94_08460	COG2302	S4 RNA-binding domain
HGH94_08465	COG3599	regulation of cell shape
HGH94_08470	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HGH94_08475	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HGH94_08480	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HGH94_08485	COG0564	pseudouridine synthase activity
HGH94_08490	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HGH94_08495	COG2233	PERMEase
HGH94_08500	COG0540	Belongs to the ATCase OTCase family
HGH94_08505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HGH94_08510	COG0505	Belongs to the CarA family
HGH94_08515	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HGH94_08520	COG0543	2 iron, 2 sulfur cluster binding
HGH94_08525	COG0167	dihydroorotate dehydrogenase activity
HGH94_08530	COG0284	orotidine-5'-phosphate decarboxylase activity
HGH94_08535	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HGH94_08545	COG0306	phosphate transporter
HGH94_08550	COG2046	Belongs to the sulfate adenylyltransferase family
HGH94_08555	COG0529	Catalyzes the synthesis of activated sulfate
HGH94_08560	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HGH94_08565	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HGH94_08570	COG1648	precorrin-2 dehydrogenase activity
HGH94_08575	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HGH94_08585	COG1561	YicC-like family, N-terminal region
HGH94_08595	COG0194	GDP metabolic process
HGH94_08600	COG1758	RNA polymerase activity
HGH94_08605	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HGH94_08615	COG0242	peptide deformylase activity
HGH94_08620	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HGH94_08625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HGH94_08625	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HGH94_08630	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HGH94_08635	COG0631	protein serine/threonine phosphatase activity
HGH94_08640	COG0515	serine threonine protein kinase
HGH94_08640	COG2815	serine threonine protein kinase
HGH94_08645	COG1162	GTPase activity
HGH94_08650	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HGH94_08655	COG1564	THIamine pyrophosphokinase
HGH94_08665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HGH94_08670	COG1302	Protein conserved in bacteria
HGH94_08675	COG1461	Dihydroxyacetone kinase
HGH94_08680	COG1760	l-serine dehydratase
HGH94_08685	COG1760	l-serine dehydratase
HGH94_08690	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HGH94_08695	COG2050	protein possibly involved in aromatic compounds catabolism
HGH94_08695	COG1349	DNA-binding transcription factor activity
HGH94_08705	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HGH94_08720	COG0571	ribonuclease III activity
HGH94_08725	COG1196	nuclear chromosome segregation
HGH94_08730	COG0552	protein localization to endoplasmic reticulum
HGH94_08740	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HGH94_08745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HGH94_08750	COG0228	four-way junction DNA binding
HGH94_08755	COG1837	Belongs to the UPF0109 family
HGH94_08765	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HGH94_08770	COG0336	Belongs to the RNA methyltransferase TrmD family
HGH94_08775	COG0335	large ribosomal subunit rRNA binding
HGH94_08780	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HGH94_08785	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HGH94_08795	COG2257	FlhB HrpN YscU SpaS Family
HGH94_08800	COG0045	succinate-CoA ligase (ADP-forming) activity
HGH94_08805	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HGH94_08810	COG0758	DNA mediated transformation
HGH94_08815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HGH94_08820	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HGH94_08825	COG4974	Belongs to the 'phage' integrase family
HGH94_08830	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HGH94_08835	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HGH94_08840	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HGH94_08845	COG1815	bacterial-type flagellum-dependent cell motility
HGH94_08855	COG1677	Flagellar hook-basal body complex protein FliE
HGH94_08860	COG1766	The M ring may be actively involved in energy transduction
HGH94_08865	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HGH94_08870	COG1317	bacterial-type flagellum organization
HGH94_08875	COG1157	protein secretion by the type III secretion system
HGH94_08880	COG2882	bacterial-type flagellum organization
HGH94_08885	COG3334	PFAM MgtE intracellular
HGH94_08890	COG3144	bacterial-type flagellum assembly
HGH94_08895	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HGH94_08900	COG4786	Flagellar basal body rod
HGH94_08905	COG1582	Flagellar protein (FlbD)
HGH94_08910	COG1580	Controls the rotational direction of flagella during chemotaxis
HGH94_08915	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HGH94_08920	COG1776	CheC inhibitor of MCP methylation
HGH94_08920	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HGH94_08925	COG2201	protein-glutamate methylesterase activity
HGH94_08930	COG3190	flagellar
HGH94_08935	COG1338	Plays a role in the flagellum-specific transport system
HGH94_08940	COG1987	bacterial-type flagellum assembly
HGH94_08950	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HGH94_08955	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HGH94_08960	COG1419	protein localization to endoplasmic reticulum
HGH94_08965	COG0455	bacterial-type flagellum organization
HGH94_08970	COG2201	protein-glutamate methylesterase activity
HGH94_08980	COG0835	chemotaxis
HGH94_08985	COG1776	CheC inhibitor of MCP methylation
HGH94_08990	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HGH94_08995	COG1191	sigma factor activity
HGH94_09005	COG0052	Belongs to the universal ribosomal protein uS2 family
HGH94_09015	COG0528	UMP kinase activity
HGH94_09020	COG0233	cytoplasmic translational termination
HGH94_09025	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HGH94_09030	COG4589	Belongs to the CDS family
HGH94_09035	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HGH94_09040	COG0750	zinc metalloprotease
HGH94_09045	COG0442	prolyl-tRNA aminoacylation
HGH94_09055	COG0779	Required for maturation of 30S ribosomal subunits
HGH94_09060	COG0195	Participates in both transcription termination and antitermination
HGH94_09065	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HGH94_09070	COG1358	cellular component organization or biogenesis
HGH94_09075	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HGH94_09080	COG1550	Protein conserved in bacteria
HGH94_09085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HGH94_09090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HGH94_09095	COG0196	riboflavin kinase activity
HGH94_09100	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HGH94_09105	COG1185	polyribonucleotide nucleotidyltransferase activity
HGH94_09110	COG0726	polysaccharide deacetylase
HGH94_09115	COG0612	Peptidase, M16
HGH94_09120	COG1873	PFAM PRC-barrel domain
HGH94_09125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HGH94_09130	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HGH94_09135	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HGH94_09140	COG0527	aspartate kinase activity
HGH94_09145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HGH94_09155	COG0740	serine-type endopeptidase activity
HGH94_09165	COG1674	ftsk spoiiie
HGH94_09165	COG4980	gas vesicle protein
HGH94_09170	COG2188	Transcriptional regulator
HGH94_09175	COG2814	Major facilitator Superfamily
HGH94_09180	COG0612	Peptidase, M16
HGH94_09185	COG0612	Peptidase, M16
HGH94_09190	COG0300	oxidoreductase activity
HGH94_09205	COG1426	Protein conserved in bacteria
HGH94_09210	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HGH94_09220	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HGH94_09225	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HGH94_09230	COG1418	mRNA catabolic process
HGH94_09235	COG1692	metallophosphoesterase
HGH94_09240	COG2359	stage V sporulation protein S
HGH94_09245	COG1063	alcohol dehydrogenase
HGH94_09250	COG0156	8-amino-7-oxononanoate synthase activity
HGH94_09260	COG4550	Control of competence regulator ComK, YlbF/YmcA
HGH94_09270	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HGH94_09300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGH94_09305	COG1404	Belongs to the peptidase S8 family
HGH94_09315	COG4195	phage-related replication protein
HGH94_09320	COG1764	response to oxidative stress
HGH94_09325	COG2076	Multidrug Resistance protein
HGH94_09330	COG2076	Multidrug Resistance protein
HGH94_09350	COG1923	regulation of RNA biosynthetic process
HGH94_09365	COG1780	Probably involved in ribonucleotide reductase function
HGH94_09370	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HGH94_09375	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HGH94_09380	COG4112	unkown
HGH94_09390	COG0860	N-Acetylmuramoyl-L-alanine amidase
HGH94_09395	COG0464	growth
HGH94_09400	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HGH94_09405	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HGH94_09410	COG0789	Transcriptional regulator
HGH94_09415	COG0174	glutamine synthetase
HGH94_09450	COG0135	phosphoribosylanthranilate isomerase activity
HGH94_09455	COG3328	transposase activity
HGH94_09460	COG2211	Major facilitator Superfamily
HGH94_09465	COG3507	Belongs to the glycosyl hydrolase 43 family
HGH94_09470	COG1940	carbohydrate kinase activity
HGH94_09475	COG2115	Belongs to the xylose isomerase family
HGH94_09480	COG1070	Carbohydrate kinase
HGH94_09505	COG1525	nuclease
HGH94_09510	COG2814	Major facilitator Superfamily
HGH94_09515	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HGH94_09525	COG0756	dUTP diphosphatase activity
HGH94_09570	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HGH94_09585	COG3832	glyoxalase III activity
HGH94_09595	COG0697	spore germination
HGH94_09600	COG0531	amino acid
HGH94_09630	COG4195	phage-related replication protein
HGH94_09640	COG0346	lactoylglutathione lyase activity
HGH94_09645	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HGH94_09650	COG1388	LysM domain
HGH94_09655	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HGH94_09660	COG4224	UPF0291 protein
HGH94_09665	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HGH94_09675	COG3763	UPF0154 protein
HGH94_09685	COG0785	Cytochrome C biogenesis protein
HGH94_09690	COG2201	protein-glutamate methylesterase activity
HGH94_09695	COG4846	Membrane protein involved in cytochrome C biogenesis
HGH94_09705	COG0071	Belongs to the small heat shock protein (HSP20) family
HGH94_09720	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HGH94_09725	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HGH94_09745	COG0824	Thioesterase
HGH94_09755	COG4841	protein insertion into membrane
HGH94_09760	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HGH94_09765	COG1832	CoA-binding protein
HGH94_09770	COG0187	DNA topoisomerase II activity
HGH94_09775	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HGH94_09785	COG1115	amino acid carrier protein
HGH94_09790	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HGH94_09805	COG3507	Belongs to the glycosyl hydrolase 43 family
HGH94_09810	COG2246	polysaccharide biosynthetic process
HGH94_09815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HGH94_09820	COG0586	Pfam SNARE associated Golgi protein
HGH94_09825	COG2404	hydrolase activity, acting on ester bonds
HGH94_09830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HGH94_09835	COG1024	Enoyl-CoA hydratase
HGH94_09840	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HGH94_09845	COG0511	ligase activity, forming carbon-carbon bonds
HGH94_09850	COG0439	Biotin carboxylase
HGH94_09855	COG0318	PFAM AMP-dependent synthetase and ligase
HGH94_09860	COG1960	acyl-CoA dehydrogenase activity
HGH94_09875	COG1649	PFAM Uncharacterised BCR, COG1649
HGH94_09895	COG2027	D-alanyl-D-alanine carboxypeptidase
HGH94_09900	COG2017	converts alpha-aldose to the beta-anomer
HGH94_09905	COG0534	Mate efflux family protein
HGH94_09920	COG0582	viral genome integration into host DNA
HGH94_09925	COG0166	Belongs to the GPI family
HGH94_09930	COG0405	Gamma-glutamyltransferase
HGH94_09935	COG0583	DNA-binding transcription factor activity
HGH94_09950	COG0067	glutamate synthase
HGH94_09950	COG0070	glutamate synthase
HGH94_09950	COG0069	glutamate synthase activity
HGH94_09955	COG0583	DNA-binding transcription factor activity
HGH94_09960	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HGH94_09965	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HGH94_09975	COG0300	oxidoreductase activity
HGH94_09980	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HGH94_09990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HGH94_10005	COG1131	(ABC) transporter
HGH94_10015	COG2814	Major facilitator Superfamily
HGH94_10020	COG1070	Carbohydrate kinase
HGH94_10025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HGH94_10070	COG4305	rare lipoprotein A
HGH94_10075	COG3619	membrane
HGH94_10080	COG3866	Pectate lyase
HGH94_10085	COG2135	peptidase activity
HGH94_10125	COG2720	vancomycin resistance protein
HGH94_10145	COG0583	DNA-binding transcription factor activity
HGH94_10150	COG0697	spore germination
HGH94_10170	COG0693	protein deglycase activity
HGH94_10185	COG5444	nuclease activity
HGH94_10190	COG4282	regulation of fungal-type cell wall biogenesis
HGH94_10195	COG1231	oxidoreductase activity
HGH94_10205	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGH94_10215	COG0456	acetyltransferase
HGH94_10220	COG1309	transcriptional regulator
HGH94_10225	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGH94_10230	COG3708	Transcriptional regulator
HGH94_10235	COG2378	regulation of single-species biofilm formation
HGH94_10245	COG0640	Transcriptional regulator
HGH94_10250	COG0741	lytic transglycosylase activity
HGH94_10260	COG2322	membrane
HGH94_10280	COG3239	Fatty acid desaturase
HGH94_10285	COG4585	Histidine kinase
HGH94_10290	COG2197	response regulator
HGH94_10295	COG3584	3D domain protein
HGH94_10295	COG1388	LysM domain
HGH94_10300	COG0514	ATP-dependent DNA helicase (RecQ)
HGH94_10310	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HGH94_10315	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HGH94_10355	COG1012	belongs to the aldehyde dehydrogenase family
HGH94_10360	COG1657	PFAM Prenyltransferase squalene oxidase
HGH94_10365	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HGH94_10370	COG0733	neurotransmitter:sodium symporter activity
HGH94_10380	COG0508	dehydrogenase complex catalyzes the overall conversion of
HGH94_10385	COG0567	Dehydrogenase, E1 component
HGH94_10390	COG4548	von Willebrand factor, type A
HGH94_10395	COG0714	Associated with various cellular activities
HGH94_10400	COG2032	superoxide dismutase activity
HGH94_10405	COG0791	NLP P60 protein
HGH94_10405	COG1388	LysM domain
HGH94_10415	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HGH94_10425	COG1366	Belongs to the anti-sigma-factor antagonist family
HGH94_10430	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HGH94_10435	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HGH94_10460	COG2610	gluconate transmembrane transporter activity
HGH94_10465	COG1942	4-Oxalocrotonate Tautomerase
HGH94_10470	COG1733	regulation of RNA biosynthetic process
HGH94_10475	COG0778	Nitroreductase
HGH94_10485	COG0400	carboxylic ester hydrolase activity
HGH94_10490	COG0346	lactoylglutathione lyase activity
HGH94_10500	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HGH94_10510	COG3409	Peptidoglycan-binding domain 1 protein
HGH94_10510	COG0793	Belongs to the peptidase S41A family
HGH94_10515	COG2226	methyltransferase
HGH94_10525	COG1876	peptidase activity
HGH94_10530	COG0813	purine-nucleoside phosphorylase activity
HGH94_10545	COG0671	phosphoesterase, PA-phosphatase related
HGH94_10565	COG4479	Belongs to the UPF0346 family
HGH94_10575	COG1509	lysine 2,3-aminomutase activity
HGH94_10580	COG0456	acetyltransferase
HGH94_10585	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HGH94_10590	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HGH94_10595	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HGH94_10600	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HGH94_10615	COG0456	acetyltransferase
HGH94_10620	COG0463	Glycosyl transferase, family 2
HGH94_10640	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
HGH94_10645	COG1086	Polysaccharide biosynthesis protein
HGH94_10655	COG3331	DNA recombination
HGH94_10705	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HGH94_10735	COG0756	dUTP diphosphatase activity
HGH94_10760	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HGH94_10770	COG1372	Participates in initiation and elongation during chromosome replication
HGH94_10770	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HGH94_10775	COG1780	Probably involved in ribonucleotide reductase function
HGH94_10870	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HGH94_10895	COG3584	3D domain protein
HGH94_10905	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HGH94_10970	COG1793	dna ligase
HGH94_11005	COG4474	Belongs to the UPF0398 family
HGH94_11055	COG3655	Transcriptional regulator
HGH94_11070	COG0582	viral genome integration into host DNA
HGH94_11265	COG0776	regulation of translation
HGH94_11305	COG4373	Mu-like prophage FluMu protein gp28
HGH94_11400	COG0584	glycerophosphoryl diester phosphodiesterase
HGH94_11415	COG0582	viral genome integration into host DNA
HGH94_11430	COG1196	nuclear chromosome segregation
HGH94_11430	COG0741	lytic transglycosylase activity
HGH94_11430	COG0739	heme binding
HGH94_11440	COG2433	Pfam Transposase IS66
HGH94_11450	COG5434	Belongs to the glycosyl hydrolase 28 family
HGH94_11475	COG5632	N-Acetylmuramoyl-L-alanine amidase
HGH94_11490	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HGH94_11495	COG0463	Glycosyl transferase, family 2
HGH94_11500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HGH94_11520	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HGH94_11550	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HGH94_11570	COG5444	nuclease activity
HGH94_11585	COG1525	nuclease
HGH94_11605	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HGH94_11610	COG1086	Polysaccharide biosynthesis protein
HGH94_11615	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HGH94_11620	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HGH94_11625	COG1846	Transcriptional regulator
HGH94_11630	COG0534	Mate efflux family protein
HGH94_11640	COG4698	Protein conserved in bacteria
HGH94_11645	COG2755	lipolytic protein G-D-S-L family
HGH94_11650	COG1999	signal sequence binding
HGH94_11665	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HGH94_11670	COG1272	protein, Hemolysin III
HGH94_11675	COG0204	Acyl-transferase
HGH94_11685	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HGH94_11690	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HGH94_11700	COG2136	Putative SAM-dependent methyltransferase
HGH94_11700	COG2521	methyltransferase
HGH94_11710	COG0129	dihydroxy-acid dehydratase activity
HGH94_11715	COG1413	lyase activity
HGH94_11725	COG0386	Belongs to the glutathione peroxidase family
HGH94_11735	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HGH94_11745	COG1278	Cold shock
HGH94_11765	COG0328	RNA-DNA hybrid ribonuclease activity
HGH94_11770	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HGH94_11785	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HGH94_11800	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HGH94_11810	COG1755	Isoprenylcysteine carboxyl methyltransferase
HGH94_11815	COG3424	synthase
HGH94_11820	COG2233	PERMEase
HGH94_11825	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HGH94_11830	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HGH94_11840	COG0800	Aldolase
HGH94_11845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGH94_11855	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HGH94_11860	COG1028	Short-chain dehydrogenase reductase Sdr
HGH94_11865	COG1199	ATP-dependent helicase activity
HGH94_11895	COG4474	Belongs to the UPF0398 family
HGH94_11915	COG1111	helicase
HGH94_11915	COG1205	dead DEAH box helicase
HGH94_11920	COG2190	(PTS) system
HGH94_11925	COG0071	Belongs to the small heat shock protein (HSP20) family
HGH94_11960	COG3331	DNA recombination
HGH94_11965	COG4499	WXG100 protein secretion system (Wss), protein YukC
HGH94_11965	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HGH94_11975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HGH94_11980	COG3935	DnaD domain protein
HGH94_11985	COG0017	Asparaginyl-tRNA synthetase
HGH94_11990	COG0436	Aminotransferase
HGH94_11995	COG5353	protein conserved in bacteria
HGH94_12005	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HGH94_12005	COG1199	ATP-dependent helicase activity
HGH94_12010	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HGH94_12015	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HGH94_12020	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HGH94_12025	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HGH94_12025	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HGH94_12030	COG0617	tRNA 3'-terminal CCA addition
HGH94_12035	COG0438	transferase activity, transferring glycosyl groups
HGH94_12040	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HGH94_12045	COG1803	Methylglyoxal synthase
HGH94_12050	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HGH94_12055	COG1694	Mazg nucleotide pyrophosphohydrolase
HGH94_12060	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HGH94_12070	COG4347	Protein of unknown function (DUF1405)
HGH94_12075	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HGH94_12075	COG2010	Cytochrome c
HGH94_12080	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HGH94_12085	COG0723	plastoquinol--plastocyanin reductase activity
HGH94_12100	COG0457	Tetratricopeptide repeat
HGH94_12105	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HGH94_12110	COG0287	Prephenate dehydrogenase
HGH94_12120	COG0159	tryptophan synthase activity
HGH94_12125	COG0133	tryptophan synthase activity
HGH94_12130	COG0135	phosphoribosylanthranilate isomerase activity
HGH94_12140	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HGH94_12145	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HGH94_12150	COG4401	Chorismate mutase type I
HGH94_12155	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HGH94_12160	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HGH94_12165	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HGH94_12170	COG0105	UTP biosynthetic process
HGH94_12175	COG0142	geranyltranstransferase activity
HGH94_12180	COG2226	methyltransferase
HGH94_12185	COG0142	geranyltranstransferase activity
HGH94_12195	COG0302	gtp cyclohydrolase
HGH94_12200	COG0776	regulation of translation
HGH94_12205	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HGH94_12220	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HGH94_12225	COG1160	GTP binding
HGH94_12250	COG1304	FMN binding
HGH94_12255	COG0539	negative regulation of cytoplasmic translation
HGH94_12260	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HGH94_12270	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HGH94_12275	COG2959	enzyme of heme biosynthesis
HGH94_12280	COG3409	Peptidoglycan-binding domain 1 protein
HGH94_12280	COG3773	Cell wall hydrolase
HGH94_12285	COG2339	peptidase activity
HGH94_12290	COG0492	ferredoxin-NADP+ reductase activity
HGH94_12295	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HGH94_12300	COG4862	establishment of competence for transformation
HGH94_12305	COG1408	metallophosphoesterase
HGH94_12315	COG1388	LysM domain
HGH94_12320	COG1266	CAAX protease self-immunity
HGH94_12325	COG0514	ATP-dependent DNA helicase (RecQ)
HGH94_12330	COG4955	Helix-turn-helix domain
HGH94_12335	COG1141	Ferredoxin
HGH94_12340	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HGH94_12345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HGH94_12350	COG0710	3-dehydroquinate dehydratase activity
HGH94_12360	COG1595	DNA-templated transcription, initiation
HGH94_12365	COG5002	protein histidine kinase activity
HGH94_12370	COG0745	RESPONSE REGULATOR receiver
HGH94_12375	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HGH94_12380	COG1333	cytochrome c biogenesis protein
HGH94_12385	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HGH94_12390	COG1187	pseudouridine synthase activity
HGH94_12395	COG0700	Nucleoside recognition
HGH94_12400	COG2715	membrane protein required for spore maturation
HGH94_12405	COG1686	Belongs to the peptidase S11 family
HGH94_12415	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HGH94_12420	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HGH94_12425	COG1547	Domain of unknown function (DUF309)
HGH94_12430	COG0456	acetyltransferase
HGH94_12435	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HGH94_12440	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HGH94_12440	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HGH94_12445	COG0307	riboflavin synthase, alpha
HGH94_12450	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HGH94_12450	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HGH94_12460	COG0681	Belongs to the peptidase S26 family
HGH94_12470	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
HGH94_12490	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HGH94_12495	COG4086	secreted protein
HGH94_12520	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HGH94_12540	COG1191	sigma factor activity
HGH94_12545	COG2172	sigma factor antagonist activity
HGH94_12550	COG1366	Belongs to the anti-sigma-factor antagonist family
HGH94_12555	COG1686	Belongs to the peptidase S11 family
HGH94_12560	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HGH94_12565	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HGH94_12570	COG4974	Belongs to the 'phage' integrase family
HGH94_12580	COG0735	belongs to the Fur family
HGH94_12585	COG1300	Membrane
HGH94_12595	COG0281	malic enzyme
HGH94_12600	COG1757	Na H antiporter
HGH94_12605	COG1027	Aspartate ammonia-lyase
HGH94_12615	COG1396	sequence-specific DNA binding
HGH94_12620	COG1379	DNA repair
HGH94_12625	COG0494	nUDIX hydrolase
HGH94_12635	COG0667	Aldo Keto reductase
HGH94_12645	COG1073	alpha beta
HGH94_12655	COG4918	Iron-sulphur cluster biosynthesis
HGH94_12660	COG0456	acetyltransferase
HGH94_12660	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HGH94_12665	COG2329	Antibiotic biosynthesis monooxygenase
HGH94_12670	COG0456	acetyltransferase
HGH94_12680	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HGH94_12690	COG2211	Major facilitator Superfamily
HGH94_12700	COG0346	lactoylglutathione lyase activity
HGH94_12705	COG1072	(Pantothenic acid kinase))
HGH94_12710	COG3048	D-serine ammonia-lyase activity
HGH94_12715	COG0300	oxidoreductase activity
HGH94_12720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGH94_12725	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HGH94_12735	COG4187	Peptidase family M20/M25/M40
HGH94_12740	COG1902	pentaerythritol trinitrate reductase activity
HGH94_12745	COG0596	Alpha beta hydrolase
HGH94_12760	COG1234	tRNA 3'-trailer cleavage
HGH94_12770	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HGH94_12775	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HGH94_12785	COG0706	membrane insertase activity
HGH94_12790	COG3361	conserved protein (COG2071)
HGH94_12805	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HGH94_12810	COG0346	lactoylglutathione lyase activity
HGH94_12820	COG1376	ErfK ybiS ycfS ynhG family protein
HGH94_12825	COG4129	membrane
HGH94_12830	COG1126	abc transporter atp-binding protein
HGH94_12835	COG0765	amino acid transport
HGH94_12840	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGH94_12850	COG1597	lipid kinase activity
HGH94_12855	COG2814	Major facilitator Superfamily
HGH94_12860	COG0789	Transcriptional regulator
HGH94_12860	COG4978	Transcriptional regulator
HGH94_12865	COG0508	dehydrogenase complex catalyzes the overall conversion of
HGH94_12870	COG0022	dehydrogenase e1 component
HGH94_12875	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HGH94_12880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HGH94_12885	COG3426	butyrate kinase activity
HGH94_12890	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HGH94_12895	COG0280	phosphate acetyltransferase
HGH94_12900	COG3290	protein histidine kinase activity
HGH94_12900	COG3829	transcription factor binding
HGH94_12910	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HGH94_12915	COG2079	MmgE PrpD family protein
HGH94_12920	COG0372	Belongs to the citrate synthase family
HGH94_12925	COG1960	acyl-CoA dehydrogenase activity
HGH94_12930	COG1250	3-hydroxyacyl-CoA dehydrogenase
HGH94_12940	COG0584	glycerophosphoryl diester phosphodiesterase
HGH94_12945	COG0860	N-Acetylmuramoyl-L-alanine amidase
HGH94_12960	COG1902	pentaerythritol trinitrate reductase activity
HGH94_12965	COG0745	RESPONSE REGULATOR receiver
HGH94_12980	COG1438	arginine binding
HGH94_12985	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HGH94_12990	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HGH94_12995	COG0142	geranyltranstransferase activity
HGH94_13000	COG1722	exodeoxyribonuclease VII activity
HGH94_13005	COG1570	exodeoxyribonuclease VII activity
HGH94_13010	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HGH94_13015	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HGH94_13020	COG1302	Protein conserved in bacteria
HGH94_13025	COG0439	Biotin carboxylase
HGH94_13030	COG0511	ligase activity, forming carbon-carbon bonds
HGH94_13070	COG3854	ATPases associated with a variety of cellular activities
HGH94_13080	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HGH94_13090	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HGH94_13100	COG3872	metal-dependent enzyme
HGH94_13110	COG1752	Esterase of the alpha-beta hydrolase superfamily
HGH94_13115	COG1321	iron dependent repressor
HGH94_13120	COG0095	Lipoate-protein ligase
HGH94_13125	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HGH94_13130	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HGH94_13135	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HGH94_13140	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HGH94_13145	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HGH94_13160	COG1396	sequence-specific DNA binding
HGH94_13170	COG0681	Belongs to the peptidase S26 family
HGH94_13195	COG4940	Competence protein ComGF
HGH94_13205	COG4970	Tfp pilus assembly protein FimT
HGH94_13210	COG4537	Required for transformation and DNA binding
HGH94_13215	COG1459	type II secretion system
HGH94_13220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HGH94_13230	COG0598	Magnesium transport protein CorA
HGH94_13235	COG1253	flavin adenine dinucleotide binding
HGH94_13240	COG1366	Belongs to the anti-sigma-factor antagonist family
HGH94_13250	COG1393	Belongs to the ArsC family
HGH94_13260	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGH94_13270	COG0011	TIGRFAM Protein of
HGH94_13280	COG2866	Carboxypeptidase
HGH94_13290	COG1940	carbohydrate kinase activity
HGH94_13295	COG4483	Protein conserved in bacteria
HGH94_13300	COG0705	Rhomboid family
HGH94_13300	COG0457	Tetratricopeptide repeat
HGH94_13310	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HGH94_13320	COG0438	transferase activity, transferring glycosyl groups
HGH94_13335	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HGH94_13350	COG0581	inorganic phosphate transmembrane transporter activity
HGH94_13355	COG0573	inorganic phosphate transmembrane transporter activity
HGH94_13360	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HGH94_13375	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HGH94_13380	COG2839	Protein conserved in bacteria
HGH94_13385	COG5521	maltodextrose utilization protein MalA
HGH94_13390	COG1388	LysM domain
HGH94_13395	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HGH94_13400	COG4709	membrane
HGH94_13405	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HGH94_13415	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HGH94_13425	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HGH94_13430	COG0513	Belongs to the DEAD box helicase family
HGH94_13440	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HGH94_13450	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HGH94_13455	COG2384	SAM-dependent methyltransferase
HGH94_13460	COG2010	Cytochrome c
HGH94_13465	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HGH94_13470	COG0358	DNA primase activity
HGH94_13480	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HGH94_13485	COG0517	IMP dehydrogenase activity
HGH94_13490	COG0751	glycine-tRNA ligase activity
HGH94_13495	COG0752	glycyl-tRNA synthetase alpha subunit
HGH94_13500	COG1381	Involved in DNA repair and RecF pathway recombination
HGH94_13510	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HGH94_13515	COG0295	cytidine deaminase activity
HGH94_13520	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HGH94_13525	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HGH94_13530	COG1480	7TM receptor with intracellular HD hydrolase
HGH94_13535	COG1702	phosphate starvation-inducible protein PhoH
HGH94_13555	COG4864	UPF0365 protein
HGH94_13560	COG1030	water channel activity
HGH94_13565	COG1610	YqeY-like protein
HGH94_13575	COG1283	sodium-dependent phosphate transmembrane transporter activity
HGH94_13580	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HGH94_13585	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HGH94_13590	COG2264	protein methyltransferase activity
HGH94_13595	COG0484	heat shock protein binding
HGH94_13600	COG0443	Heat shock 70 kDa protein
HGH94_13605	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HGH94_13610	COG1420	regulation of RNA biosynthetic process
HGH94_13615	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HGH94_13620	COG0481	GTPase activity
HGH94_13630	COG0860	N-Acetylmuramoyl-L-alanine amidase
HGH94_13635	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HGH94_13640	COG0268	Binds directly to 16S ribosomal RNA
HGH94_13645	COG1466	dna polymerase III delta subunit
HGH94_13660	COG0658	competence protein
HGH94_13660	COG2333	competence protein COMEC
HGH94_13670	COG1596	polysaccharide export
HGH94_13670	COG1555	photosystem II stabilization
HGH94_13675	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HGH94_13680	COG2226	methyltransferase
HGH94_13685	COG0799	negative regulation of ribosome biogenesis
HGH94_13690	COG1713	HD superfamily hydrolase involved in NAD metabolism
HGH94_13695	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HGH94_13700	COG1534	Rna-binding protein
HGH94_13705	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HGH94_13710	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HGH94_13715	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HGH94_13725	COG2755	lipolytic protein G-D-S-L family
HGH94_13730	COG5632	N-Acetylmuramoyl-L-alanine amidase
HGH94_13730	COG3409	Peptidoglycan-binding domain 1 protein
HGH94_13735	COG0398	Pfam SNARE associated Golgi protein
HGH94_13775	COG4124	Belongs to the glycosyl hydrolase 26 family
HGH94_13780	COG0730	response to heat
HGH94_13785	COG0425	Belongs to the sulfur carrier protein TusA family
HGH94_13790	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGH94_13790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HGH94_13800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HGH94_13800	COG0425	Belongs to the sulfur carrier protein TusA family
HGH94_13810	COG2210	Belongs to the sulfur carrier protein TusA family
HGH94_13815	COG1937	Protein conserved in bacteria
HGH94_13825	COG0662	Cupin 2, conserved barrel domain protein
HGH94_13835	COG0789	Transcriptional regulator
HGH94_13835	COG4978	Transcriptional regulator
HGH94_13840	COG2814	Major facilitator Superfamily
HGH94_13845	COG0456	acetyltransferase
HGH94_13850	COG1253	flavin adenine dinucleotide binding
HGH94_13860	COG0697	spore germination
HGH94_13865	COG0583	DNA-binding transcription factor activity
HGH94_13875	COG1230	cation diffusion facilitator family transporter
HGH94_13880	COG1942	4-Oxalocrotonate Tautomerase
HGH94_13885	COG0583	DNA-binding transcription factor activity
HGH94_13895	COG1114	Component of the transport system for branched-chain amino acids
HGH94_13900	COG1687	branched-chain amino acid
HGH94_13910	COG1522	sequence-specific DNA binding
HGH94_13915	COG2732	(Barnase) inhibitor
HGH94_13935	COG1335	isochorismatase
HGH94_13955	COG2318	DinB family
HGH94_13965	COG2070	2-Nitropropane dioxygenase
HGH94_13970	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HGH94_13990	COG3443	Belongs to the bacterial solute-binding protein 9 family
HGH94_13995	COG1595	DNA-templated transcription, initiation
HGH94_14000	COG0667	Aldo Keto reductase
HGH94_14005	COG2851	Citrate transporter
HGH94_14010	COG0583	DNA-binding transcription factor activity
HGH94_14015	COG2828	Protein conserved in bacteria
HGH94_14025	COG5566	PFAM Mor transcription activator
HGH94_14030	COG0596	Alpha beta hydrolase
HGH94_14035	COG4991	sh3 domain protein
HGH94_14040	COG4991	sh3 domain protein
HGH94_14050	COG0346	lactoylglutathione lyase activity
HGH94_14060	COG5577	PFAM Coat F domain
HGH94_14065	COG1063	alcohol dehydrogenase
HGH94_14090	COG0789	Transcriptional regulator
HGH94_14100	COG1064	alcohol dehydrogenase
HGH94_14105	COG0693	protein deglycase activity
HGH94_14115	COG3716	PTS system mannose fructose sorbose family IID component
HGH94_14120	COG3715	PTS system
HGH94_14125	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HGH94_14130	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGH94_14135	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HGH94_14135	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HGH94_14145	COG1113	amino acid transport
HGH94_14150	COG1280	lysine exporter protein (LysE YggA)
HGH94_14155	COG1378	Sugar-specific transcriptional regulator TrmB
HGH94_14160	COG1595	DNA-templated transcription, initiation
HGH94_14170	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HGH94_14170	COG2755	lipolytic protein G-D-S-L family
HGH94_14180	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HGH94_14180	COG2124	cytochrome p450
HGH94_14185	COG1309	transcriptional regulator
HGH94_14190	COG2226	methyltransferase
HGH94_14205	COG2116	formate transmembrane transporter activity
HGH94_14210	COG5609	conserved protein (DUF2294)
HGH94_14230	COG0626	cystathionine gamma-synthase activity
HGH94_14235	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HGH94_14240	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HGH94_14245	COG2226	methyltransferase
HGH94_14260	COG0768	penicillin binding
HGH94_14265	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HGH94_14270	COG0572	uridine kinase
HGH94_14285	COG4122	O-methyltransferase activity
HGH94_14290	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HGH94_14295	COG3906	Belongs to the UPF0473 family
HGH94_14300	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HGH94_14305	COG4472	Bacterial protein of unknown function (DUF965)
HGH94_14310	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HGH94_14315	COG0628	permease
HGH94_14320	COG1126	abc transporter atp-binding protein
HGH94_14325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGH94_14330	COG0765	amino acid transport
HGH94_14335	COG0765	amino acid transport
HGH94_14350	COG3881	PFAM PRC-barrel domain
HGH94_14355	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HGH94_14360	COG0457	Tetratricopeptide repeat
HGH94_14365	COG0482	sulfurtransferase activity
HGH94_14370	COG1104	cysteine desulfurase activity
HGH94_14375	COG1959	2 iron, 2 sulfur cluster binding
HGH94_14380	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HGH94_14395	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HGH94_14400	COG0124	histidyl-tRNA synthetase
HGH94_14410	COG4991	sh3 domain protein
HGH94_14410	COG0860	N-Acetylmuramoyl-L-alanine amidase
HGH94_14410	COG3103	Sh3 type 3 domain protein
HGH94_14415	COG1490	D-aminoacyl-tRNA deacylase activity
HGH94_14420	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HGH94_14425	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HGH94_14430	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HGH94_14430	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HGH94_14435	COG5416	Lipopolysaccharide assembly protein A domain
HGH94_14440	COG0490	domain, Protein
HGH94_14445	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HGH94_14445	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HGH94_14455	COG2244	polysaccharide biosynthetic process
HGH94_14460	COG2323	membrane
HGH94_14470	COG1862	Preprotein translocase
HGH94_14475	COG0343	queuine tRNA-ribosyltransferase activity
HGH94_14480	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HGH94_14490	COG2255	four-way junction helicase activity
HGH94_14495	COG0632	four-way junction helicase activity
HGH94_14505	COG2814	Major facilitator Superfamily
HGH94_14515	COG2112	serine threonine protein kinase
HGH94_14535	COG1115	amino acid carrier protein
HGH94_14540	COG0217	transcriptional regulatory protein
HGH94_14550	COG1388	LysM domain
HGH94_14555	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HGH94_14560	COG0157	Belongs to the NadC ModD family
HGH94_14565	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HGH94_14570	COG1104	cysteine desulfurase activity
HGH94_14575	COG1827	regulation of RNA biosynthetic process
HGH94_14580	COG0077	Prephenate dehydratase
HGH94_14585	COG4492	Belongs to the UPF0735 family
HGH94_14590	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HGH94_14595	COG3290	protein histidine kinase activity
HGH94_14605	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HGH94_14610	COG2868	ribosomal protein
HGH94_14615	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HGH94_14620	COG1994	Peptidase M50
HGH94_14625	COG0739	heme binding
HGH94_14630	COG2894	cell division
HGH94_14635	COG0850	regulation of cytokinetic process
HGH94_14640	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HGH94_14655	COG2003	Belongs to the UPF0758 family
HGH94_14670	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HGH94_14675	COG0285	dihydrofolate synthase activity
HGH94_14680	COG0525	valine-tRNA ligase activity
HGH94_14690	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HGH94_14695	COG1388	LysM domain
HGH94_14700	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HGH94_14705	COG0113	porphobilinogen synthase activity
HGH94_14710	COG1587	Uroporphyrinogen-III synthase
HGH94_14715	COG0181	hydroxymethylbilane synthase activity
HGH94_14720	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HGH94_14725	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HGH94_14735	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HGH94_14740	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HGH94_14745	COG1067	ATP-dependent peptidase activity
HGH94_14745	COG0470	DNA polymerase III
HGH94_14750	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HGH94_14755	COG0544	peptidyl-prolyl cis-trans isomerase activity
HGH94_14760	COG1477	protein flavinylation
HGH94_14760	COG0457	Tetratricopeptide repeat
HGH94_14765	COG0066	3-isopropylmalate dehydratase activity
HGH94_14775	COG0473	3-isopropylmalate dehydrogenase activity
HGH94_14780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HGH94_14785	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HGH94_14790	COG0440	acetolactate synthase activity
HGH94_14795	COG0028	Belongs to the TPP enzyme family
HGH94_14805	COG0454	-acetyltransferase
HGH94_14810	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HGH94_14820	COG0622	Phosphoesterase
HGH94_14825	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HGH94_14830	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HGH94_14835	COG5401	PFAM Sporulation and spore germination
HGH94_14840	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HGH94_14850	COG2197	response regulator
HGH94_14860	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HGH94_14865	COG1053	succinate dehydrogenase
HGH94_14870	COG2009	succinate dehydrogenase
HGH94_14875	COG1719	4-vinyl reductase, 4VR
HGH94_14885	COG0322	excinuclease ABC activity
HGH94_14890	COG3118	belongs to the thioredoxin family
HGH94_14895	COG3534	alpha-L-arabinofuranosidase
HGH94_14900	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HGH94_14905	COG2086	electron transfer activity
HGH94_14910	COG1024	Enoyl-CoA hydratase
HGH94_14915	COG1309	transcriptional regulator
HGH94_14925	COG3766	membrane
HGH94_14930	COG1193	negative regulation of DNA recombination
HGH94_14940	COG1286	toxin biosynthetic process
HGH94_14945	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HGH94_14950	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HGH94_14955	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGH94_14955	COG0072	phenylalanine-tRNA ligase activity
HGH94_14960	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HGH94_14970	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HGH94_14980	COG3835	regulator
HGH94_14985	COG0277	FAD linked oxidase domain protein
HGH94_14990	COG0247	lactate metabolic process
HGH94_14995	COG0346	lactoylglutathione lyase activity
HGH94_15000	COG1966	Carbon starvation protein
HGH94_15005	COG3534	alpha-L-arabinofuranosidase
HGH94_15010	COG0395	ABC-type sugar transport system, permease component
HGH94_15015	COG1175	transmembrane transport
HGH94_15020	COG1653	transport
HGH94_15025	COG0371	Dehydrogenase
HGH94_15030	COG0647	UMP catabolic process
HGH94_15035	COG0235	Class ii aldolase
HGH94_15040	COG1069	ribulokinase activity
HGH94_15045	COG2160	L-arabinose isomerase activity
HGH94_15050	COG3507	Belongs to the glycosyl hydrolase 43 family
HGH94_15055	COG1363	Peptidase, m42
HGH94_15065	COG3326	Membrane
HGH94_15070	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HGH94_15075	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HGH94_15080	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HGH94_15090	COG1346	cytolysis
HGH94_15095	COG1380	Effector of murein hydrolase LrgA
HGH94_15100	COG3279	Response regulator of the LytR AlgR family
HGH94_15105	COG3275	phosphorelay sensor kinase activity
HGH94_15110	COG1011	Hydrolase
HGH94_15115	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HGH94_15125	COG0398	Pfam SNARE associated Golgi protein
HGH94_15130	COG1484	DNA-dependent DNA replication
HGH94_15140	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HGH94_15145	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HGH94_15160	COG2814	Major facilitator Superfamily
HGH94_15165	COG0656	L-ascorbic acid biosynthetic process
HGH94_15175	COG0237	dephospho-CoA kinase activity
HGH94_15180	COG1971	Probably functions as a manganese efflux pump
HGH94_15185	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HGH94_15190	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HGH94_15190	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HGH94_15195	COG5002	protein histidine kinase activity
HGH94_15200	COG0745	RESPONSE REGULATOR receiver
HGH94_15205	COG0039	L-malate dehydrogenase activity
HGH94_15210	COG0538	isocitrate dehydrogenase activity
HGH94_15215	COG0372	Belongs to the citrate synthase family
HGH94_15220	COG2707	UPF0756 membrane protein
HGH94_15225	COG0628	permease
HGH94_15235	COG0469	pyruvate kinase activity
HGH94_15240	COG0205	6-phosphofructokinase activity
HGH94_15245	COG0825	malonyl-CoA metabolic process
HGH94_15255	COG0281	malic enzyme
HGH94_15260	COG0587	DNA-directed DNA polymerase activity
HGH94_15280	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HGH94_15295	COG0730	response to heat
HGH94_15305	COG0196	riboflavin kinase activity
HGH94_15310	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGH94_15315	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HGH94_15320	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGH94_15325	COG1126	abc transporter atp-binding protein
HGH94_15330	COG0765	amino acid transport
HGH94_15335	COG0765	amino acid transport
HGH94_15340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGH94_15345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGH94_15350	COG0454	-acetyltransferase
HGH94_15355	COG0583	DNA-binding transcription factor activity
HGH94_15360	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HGH94_15370	COG0165	Argininosuccinate lyase
HGH94_15375	COG0137	argininosuccinate synthase activity
HGH94_15380	COG0521	Mo-molybdopterin cofactor biosynthetic process
HGH94_15385	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HGH94_15395	COG0827	DNA restriction-modification system
HGH94_15400	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HGH94_15405	COG3874	Sporulation protein YtfJ
HGH94_15415	COG1714	RDD family
HGH94_15425	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HGH94_15430	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HGH94_15450	COG1104	cysteine desulfurase activity
HGH94_15460	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HGH94_15465	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HGH94_15470	COG1309	transcriptional regulator
HGH94_15475	COG1956	GAF domain-containing protein
HGH94_15485	COG2203	Gaf domain
HGH94_15485	COG2199	diguanylate cyclase activity
HGH94_15495	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HGH94_15505	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HGH94_15510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HGH94_15515	COG0454	-acetyltransferase
HGH94_15520	COG0517	IMP dehydrogenase activity
HGH94_15525	COG0123	including yeast histone deacetylase and acetoin utilization protein
HGH94_15530	COG1360	Flagellar Motor Protein
HGH94_15535	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HGH94_15540	COG1609	Transcriptional regulator
HGH94_15545	COG1605	Chorismate mutase
HGH94_15545	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HGH94_15550	COG3118	belongs to the thioredoxin family
HGH94_15555	COG4980	gas vesicle protein
HGH94_15560	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HGH94_15565	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HGH94_15570	COG1674	ftsk spoiiie
HGH94_15575	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HGH94_15580	COG4848	Belongs to the UPF0354 family
HGH94_15585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HGH94_15600	COG1363	Peptidase, m42
HGH94_15605	COG5584	Small secreted protein
HGH94_15610	COG0281	malic enzyme
HGH94_15615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HGH94_15620	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HGH94_15630	COG0510	thiamine kinase activity
HGH94_15635	COG1523	belongs to the glycosyl hydrolase 13 family
HGH94_15640	COG1597	lipid kinase activity
HGH94_15650	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HGH94_15655	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HGH94_15660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HGH94_15670	COG4473	ABC transporter
HGH94_15675	COG1131	(ABC) transporter
HGH94_15680	COG1349	DNA-binding transcription factor activity
HGH94_15685	COG1187	pseudouridine synthase activity
HGH94_15690	COG2244	polysaccharide biosynthetic process
HGH94_15695	COG2081	HI0933 family
HGH94_15725	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HGH94_15740	COG1653	transport
HGH94_15745	COG0395	ABC-type sugar transport system, permease component
HGH94_15750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HGH94_15760	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HGH94_15770	COG0156	8-amino-7-oxononanoate synthase activity
HGH94_15780	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
HGH94_15785	COG1073	alpha beta
HGH94_15790	COG1609	Transcriptional regulator
HGH94_15795	COG1653	transport
HGH94_15800	COG1175	transmembrane transport
HGH94_15805	COG0395	ABC-type sugar transport system, permease component
HGH94_15810	COG1486	melibiose metabolic process
HGH94_15815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HGH94_15820	COG0495	leucyl-tRNA aminoacylation
HGH94_15830	COG1366	Belongs to the anti-sigma-factor antagonist family
HGH94_15830	COG2202	Pas domain
HGH94_15835	COG2814	Major facilitator Superfamily
HGH94_15840	COG2433	Pfam Transposase IS66
HGH94_15860	COG1136	(ABC) transporter
HGH94_15865	COG2205	protein histidine kinase activity
HGH94_15870	COG0745	RESPONSE REGULATOR receiver
HGH94_15875	COG0577	efflux transmembrane transporter activity
HGH94_15880	COG1136	(ABC) transporter
HGH94_15895	COG1131	(ABC) transporter
HGH94_15900	COG1725	Transcriptional regulator
HGH94_15915	COG1242	4 iron, 4 sulfur cluster binding
HGH94_15920	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HGH94_15930	COG2267	carboxylic ester hydrolase activity
HGH94_15935	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HGH94_15940	COG1113	amino acid transport
HGH94_15950	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HGH94_15955	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HGH94_15965	COG1506	peptidase
HGH94_15970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HGH94_15975	COG1116	anion transmembrane transporter activity
HGH94_15980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HGH94_15985	COG0494	nUDIX hydrolase
HGH94_15990	COG4824	toxin secretion phage lysis holin
HGH94_15995	COG0783	Belongs to the Dps family
HGH94_16010	COG1854	S-ribosylhomocysteine lyase activity
HGH94_16015	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HGH94_16020	COG0288	reversible hydration of carbon dioxide
HGH94_16025	COG0254	rRNA binding
HGH94_16030	COG1271	oxidase subunit
HGH94_16035	COG1294	oxidase, subunit
HGH94_16045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HGH94_16050	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HGH94_16050	COG1321	iron dependent repressor
HGH94_16055	COG1121	(ABC) transporter
HGH94_16060	COG0803	Belongs to the bacterial solute-binding protein 9 family
HGH94_16065	COG4948	Mandelate Racemase Muconate Lactonizing
HGH94_16075	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HGH94_16080	COG0596	Alpha beta hydrolase
HGH94_16085	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HGH94_16090	COG1169	isochorismate synthase
HGH94_16095	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HGH94_16100	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HGH94_16105	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HGH94_16110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HGH94_16115	COG0438	transferase activity, transferring glycosyl groups
HGH94_16125	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HGH94_16130	COG0438	transferase activity, transferring glycosyl groups
HGH94_16135	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HGH94_16140	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HGH94_16145	COG0058	SHG alpha-glucan phosphorylase activity
HGH94_16150	COG0297	glycogen (starch) synthase activity
HGH94_16155	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HGH94_16165	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HGH94_16290	COG3859	Proton-coupled thiamine transporter YuaJ
HGH94_16295	COG1247	-acetyltransferase
HGH94_16300	COG2268	Band 7 protein
HGH94_16305	COG1585	Membrane protein implicated in regulation of membrane protease activity
HGH94_16310	COG2318	DinB family
HGH94_16320	COG1454	alcohol dehydrogenase
HGH94_16325	COG1012	belongs to the aldehyde dehydrogenase family
HGH94_16330	COG1510	regulation of RNA biosynthetic process
HGH94_16345	COG0569	domain protein
HGH94_16350	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HGH94_16355	COG4682	membrane
HGH94_16360	COG1705	Flagellar rod assembly protein muramidase FlgJ
HGH94_16370	COG5553	Cysteine dioxygenase type I
HGH94_16380	COG1968	undecaprenyl-diphosphatase activity
HGH94_16385	COG0628	permease
HGH94_16390	COG0673	inositol 2-dehydrogenase activity
HGH94_16395	COG4806	L-rhamnose isomerase
HGH94_16400	COG3254	rhamnose metabolic process
HGH94_16405	COG1070	Carbohydrate kinase
HGH94_16410	COG1349	DNA-binding transcription factor activity
HGH94_16415	COG3347	Dehydrogenase
HGH94_16415	COG1028	Short-chain dehydrogenase reductase Sdr
HGH94_16420	COG0840	transmembrane signaling receptor activity
HGH94_16435	COG0840	transmembrane signaling receptor activity
HGH94_16455	COG0432	Pfam Uncharacterised protein family UPF0047
HGH94_16465	COG0366	Alpha amylase catalytic
HGH94_16470	COG1253	flavin adenine dinucleotide binding
HGH94_16475	COG2738	Putative neutral zinc metallopeptidase
HGH94_16490	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HGH94_16505	COG0166	Belongs to the GPI family
HGH94_16510	COG1979	alcohol dehydrogenase
HGH94_16515	COG1979	alcohol dehydrogenase
HGH94_16520	COG2155	Conserved Protein
HGH94_16525	COG1098	S1 RNA binding domain
HGH94_16530	COG0436	Aminotransferase
HGH94_16535	COG1522	sequence-specific DNA binding
HGH94_16540	COG2267	carboxylic ester hydrolase activity
HGH94_16550	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HGH94_16555	COG2205	protein histidine kinase activity
HGH94_16565	COG5018	Exonuclease
HGH94_16575	COG2814	Major facilitator Superfamily
HGH94_16580	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HGH94_16585	COG3011	Protein conserved in bacteria
HGH94_16595	COG3290	protein histidine kinase activity
HGH94_16600	COG4565	transcriptional regulatory protein
HGH94_16625	COG3493	citrate carrier protein
HGH94_16635	COG2111	Na H antiporter
HGH94_16635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HGH94_16640	COG2111	Na H antiporter
HGH94_16645	COG1006	Multisubunit Na H antiporter MnhC subunit
HGH94_16650	COG0651	ATP synthesis coupled electron transport
HGH94_16655	COG1863	multisubunit Na H antiporter MnhE subunit
HGH94_16660	COG2212	antiporter activity
HGH94_16665	COG1320	monovalent cation:proton antiporter activity
HGH94_16670	COG2050	protein possibly involved in aromatic compounds catabolism
HGH94_16675	COG2197	response regulator
HGH94_16690	COG0142	geranyltranstransferase activity
HGH94_16710	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HGH94_16715	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HGH94_16720	COG1335	isochorismatase
HGH94_16725	COG5506	Protein of unknown function (DUF1694)
HGH94_16740	COG0628	permease
HGH94_16755	COG1418	mRNA catabolic process
HGH94_16760	COG1028	Short-chain dehydrogenase reductase Sdr
HGH94_16770	COG1511	domain protein
HGH94_16775	COG0433	COG0433 Predicted ATPase
HGH94_16775	COG1674	ftsk spoiiie
HGH94_16780	COG4499	WXG100 protein secretion system (Wss), protein YukC
HGH94_16785	COG5417	Belongs to the EsaB family
HGH94_16790	COG4842	Belongs to the WXG100 family
HGH94_16795	COG2508	Transcriptional regulator
HGH94_16795	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HGH94_16800	COG0686	Belongs to the AlaDH PNT family
HGH94_16805	COG5634	Uncharacterized conserved protein (DUF2278)
HGH94_16810	COG3251	PFAM MbtH domain protein
HGH94_16820	COG3433	isochorismatase activity
HGH94_16820	COG1535	isochorismatase
HGH94_16825	COG1021	2,3-dihydroxybenzoate-AMP ligase
HGH94_16830	COG1169	isochorismate synthase
HGH94_16835	COG1028	Short-chain dehydrogenase reductase Sdr
HGH94_16840	COG2819	hydrolase of the alpha beta superfamily
HGH94_16845	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HGH94_16850	COG1268	BioY protein
HGH94_16855	COG2056	Na+-H+ antiporter family
HGH94_16860	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HGH94_16865	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HGH94_16870	COG3584	3D domain protein
HGH94_16890	COG0492	ferredoxin-NADP+ reductase activity
HGH94_16900	COG0516	GMP reductase activity
HGH94_16910	COG2808	Putative FMN-binding domain
HGH94_16915	COG0456	acetyltransferase
HGH94_16920	COG0316	Belongs to the HesB IscA family
HGH94_16925	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HGH94_16930	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HGH94_16935	COG4844	belongs to the
HGH94_16940	COG1252	NADH dehydrogenase
HGH94_16945	COG4837	Protein of unknown function (DUF1462)
HGH94_16950	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HGH94_16960	COG0083	homoserine kinase activity
HGH94_16965	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HGH94_16970	COG0460	homoserine dehydrogenase
HGH94_16975	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HGH94_16985	COG0647	UMP catabolic process
HGH94_16990	COG2445	Protein of unknown function DUF86
HGH94_16995	COG4470	Protein conserved in bacteria
HGH94_17005	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HGH94_17020	COG3377	Domain of unknown function (DUF1805)
HGH94_17025	COG0737	Belongs to the 5'-nucleotidase family
HGH94_17030	COG0730	response to heat
HGH94_17035	COG1801	Protein of unknown function DUF72
HGH94_17045	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HGH94_17050	COG2508	Transcriptional regulator
HGH94_17055	COG2233	PERMEase
HGH94_17060	COG2233	PERMEase
HGH94_17065	COG3195	allantoin biosynthetic process
HGH94_17065	COG3648	Uricase
HGH94_17070	COG2351	hydroxyisourate hydrolase activity
HGH94_17080	COG2080	2 iron, 2 sulfur cluster binding
HGH94_17085	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HGH94_17090	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HGH94_17095	COG2068	MobA-Related Protein
HGH94_17100	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HGH94_17105	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HGH94_17110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HGH94_17120	COG2356	endonuclease I
HGH94_17135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HGH94_17160	COG0527	aspartate kinase activity
HGH94_17165	COG3842	ATPase activity
HGH94_17170	COG2188	Transcriptional regulator
HGH94_17190	COG2222	sugar isomerase
HGH94_17200	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HGH94_17220	COG0346	lactoylglutathione lyase activity
HGH94_17225	COG0640	Transcriptional regulator
HGH94_17230	COG0719	Fe-S assembly protein
HGH94_17235	COG0822	iron-sulfur transferase activity
HGH94_17240	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HGH94_17245	COG0719	Fe-S assembly protein
HGH94_17250	COG0396	ATPase activity
HGH94_17265	COG1464	Belongs to the NlpA lipoprotein family
HGH94_17270	COG2011	ABC-type metal ion transport system permease component
HGH94_17275	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HGH94_17285	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HGH94_17290	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HGH94_17300	COG0509	glycine decarboxylation via glycine cleavage system
HGH94_17305	COG1393	Belongs to the ArsC family
HGH94_17310	COG1960	acyl-CoA dehydrogenase activity
HGH94_17315	COG0183	Belongs to the thiolase family
HGH94_17320	COG1024	Enoyl-CoA hydratase
HGH94_17320	COG1250	3-hydroxyacyl-CoA dehydrogenase
HGH94_17330	COG0506	proline dehydrogenase activity
HGH94_17340	COG5577	PFAM Coat F domain
HGH94_17345	COG1846	Transcriptional regulator
HGH94_17350	COG0477	Major facilitator Superfamily
HGH94_17355	COG1942	4-Oxalocrotonate Tautomerase
HGH94_17360	COG1028	Short-chain dehydrogenase reductase Sdr
HGH94_17375	COG1120	ATPase activity
HGH94_17390	COG1028	Short-chain dehydrogenase reductase Sdr
HGH94_17395	COG0783	Belongs to the Dps family
HGH94_17400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HGH94_17405	COG0745	RESPONSE REGULATOR receiver
HGH94_17410	COG2205	protein histidine kinase activity
HGH94_17410	COG2770	Histidine kinase
HGH94_17420	COG1309	transcriptional regulator
HGH94_17425	COG0114	fumarate hydratase activity
HGH94_17435	COG0697	spore germination
HGH94_17450	COG2197	response regulator
HGH94_17455	COG4585	Histidine kinase
HGH94_17460	COG4758	membrane
HGH94_17465	COG3595	metallopeptidase activity
HGH94_17470	COG1842	Phage shock protein A
HGH94_17480	COG2814	Major facilitator Superfamily
HGH94_17485	COG2096	Adenosyltransferase
HGH94_17490	COG1120	ATPase activity
HGH94_17495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HGH94_17500	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HGH94_17505	COG1028	Short-chain dehydrogenase reductase Sdr
HGH94_17510	COG3386	PFAM SMP-30 Gluconolaconase
HGH94_17515	COG2205	protein histidine kinase activity
HGH94_17520	COG0745	RESPONSE REGULATOR receiver
HGH94_17530	COG1191	sigma factor activity
HGH94_17540	COG2140	Oxalate decarboxylase
HGH94_17550	COG0577	efflux transmembrane transporter activity
HGH94_17555	COG1136	(ABC) transporter
HGH94_17560	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HGH94_17565	COG1120	ATPase activity
HGH94_17570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HGH94_17575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HGH94_17580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HGH94_17585	COG0531	amino acid
HGH94_17595	COG1988	membrane-bound metal-dependent
HGH94_17600	COG1368	sulfuric ester hydrolase activity
HGH94_17605	COG1910	domain protein
HGH94_17610	COG0725	ABC transporter, periplasmic molybdate-binding protein
HGH94_17615	COG4149	molybdate abc transporter
HGH94_17620	COG0656	L-ascorbic acid biosynthetic process
HGH94_17630	COG0025	NhaP-type Na H and K H
HGH94_17635	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HGH94_17645	COG3973	AAA domain
HGH94_17650	COG2860	membrane
HGH94_17655	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HGH94_17660	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HGH94_17665	COG2217	Heavy metal translocating P-type atpase
HGH94_17675	COG2608	mercury ion transmembrane transporter activity
HGH94_17680	COG1937	Protein conserved in bacteria
HGH94_17685	COG0673	inositol 2-dehydrogenase activity
HGH94_17690	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HGH94_17695	COG1289	transmembrane transporter activity
HGH94_17705	COG2076	Multidrug Resistance protein
HGH94_17710	COG1309	transcriptional regulator
HGH94_17715	COG1028	Short-chain dehydrogenase reductase Sdr
HGH94_17725	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HGH94_17730	COG0557	exoribonuclease II activity
HGH94_17735	COG1647	Serine aminopeptidase, S33
HGH94_17740	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HGH94_17745	COG0596	Alpha beta hydrolase
HGH94_17750	COG1476	TRANSCRIPTIONal
HGH94_17755	COG1396	sequence-specific DNA binding
HGH94_17760	COG1396	sequence-specific DNA binding
HGH94_17765	COG1733	regulation of RNA biosynthetic process
HGH94_17775	COG1174	glycine betaine transport
HGH94_17780	COG1732	Glycine betaine
HGH94_17785	COG1174	glycine betaine transport
HGH94_17790	COG1125	glycine betaine transport
HGH94_17790	COG0517	IMP dehydrogenase activity
HGH94_17795	COG1510	regulation of RNA biosynthetic process
HGH94_17815	COG5658	integral membrane protein
HGH94_17820	COG0640	Transcriptional regulator
HGH94_17825	COG1174	glycine betaine transport
HGH94_17830	COG1732	Glycine betaine
HGH94_17835	COG1174	glycine betaine transport
HGH94_17840	COG1125	glycine betaine transport
HGH94_17840	COG0517	IMP dehydrogenase activity
HGH94_17845	COG1510	regulation of RNA biosynthetic process
HGH94_17850	COG2095	MarC family integral membrane protein
HGH94_17860	COG3064	Membrane
HGH94_17865	COG4640	response to antibiotic
HGH94_17870	COG0456	acetyltransferase
HGH94_17875	COG0148	phosphopyruvate hydratase activity
HGH94_17880	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HGH94_17885	COG0149	triose-phosphate isomerase activity
HGH94_17890	COG0126	phosphoglycerate kinase activity
HGH94_17895	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HGH94_17900	COG2390	Transcriptional regulator
HGH94_17910	COG1609	Transcriptional regulator
HGH94_17915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGH94_17920	COG0583	DNA-binding transcription factor activity
HGH94_17925	COG0697	spore germination
HGH94_17930	COG1113	amino acid transport
HGH94_17935	COG3858	chitin binding
HGH94_17940	COG1556	Lactate utilization protein
HGH94_17945	COG1139	Iron-sulfur cluster binding protein
HGH94_17950	COG0247	lactate metabolic process
HGH94_17975	COG0842	Transport permease protein
HGH94_17985	COG0596	Alpha beta hydrolase
HGH94_17990	COG2208	phosphoserine phosphatase activity
HGH94_18000	COG1874	Beta-galactosidase
HGH94_18005	COG3833	ABC-type maltose transport systems, permease component
HGH94_18010	COG1175	transmembrane transport
HGH94_18020	COG1609	Transcriptional regulator
HGH94_18025	COG2186	Transcriptional regulator
HGH94_18030	COG1620	l-lactate permease
HGH94_18035	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HGH94_18045	COG5039	Polysaccharide pyruvyl transferase
HGH94_18050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HGH94_18055	COG0110	maltose O-acetyltransferase activity
HGH94_18060	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HGH94_18065	COG2244	polysaccharide biosynthetic process
HGH94_18070	COG5039	Polysaccharide pyruvyl transferase
HGH94_18075	COG1216	Glycosyl transferase, family 2
HGH94_18085	COG0438	transferase activity, transferring glycosyl groups
HGH94_18090	COG1215	transferase activity, transferring glycosyl groups
HGH94_18095	COG0438	transferase activity, transferring glycosyl groups
HGH94_18100	COG1086	Polysaccharide biosynthesis protein
HGH94_18105	COG0489	protein tyrosine kinase activity
HGH94_18110	COG3944	biosynthesis protein
HGH94_18115	COG1396	sequence-specific DNA binding
HGH94_18120	COG2272	Belongs to the type-B carboxylesterase lipase family
HGH94_18130	COG3479	Phenolic acid decarboxylase
HGH94_18140	COG1794	racemase activity, acting on amino acids and derivatives
HGH94_18145	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HGH94_18155	COG1621	beta-fructofuranosidase activity
HGH94_18160	COG0531	amino acid
HGH94_18165	COG1309	transcriptional regulator
HGH94_18170	COG2076	Multidrug Resistance protein
HGH94_18175	COG2076	Multidrug Resistance protein
HGH94_18190	COG0740	serine-type endopeptidase activity
HGH94_18195	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HGH94_18200	COG0366	Alpha amylase catalytic
HGH94_18210	COG5521	maltodextrose utilization protein MalA
HGH94_18215	COG3833	ABC-type maltose transport systems, permease component
HGH94_18220	COG1175	transmembrane transport
HGH94_18225	COG2182	Extracellular solute-binding protein
HGH94_18230	COG0366	Alpha amylase catalytic
HGH94_18235	COG1609	Transcriptional regulator
HGH94_18240	COG1611	Belongs to the LOG family
HGH94_18245	COG1694	Mazg nucleotide pyrophosphohydrolase
HGH94_18250	COG0659	secondary active sulfate transmembrane transporter activity
HGH94_18255	COG0288	reversible hydration of carbon dioxide
HGH94_18260	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HGH94_18270	COG1136	(ABC) transporter
HGH94_18275	COG5002	protein histidine kinase activity
HGH94_18280	COG0745	RESPONSE REGULATOR receiver
HGH94_18290	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HGH94_18295	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGH94_18300	COG1481	regulation of sporulation
HGH94_18305	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HGH94_18310	COG1660	Displays ATPase and GTPase activities
HGH94_18315	COG1051	belongs to the nudix hydrolase family
HGH94_18320	COG0492	ferredoxin-NADP+ reductase activity
HGH94_18325	COG3883	PFAM NLP P60 protein
HGH94_18325	COG0791	NLP P60 protein
HGH94_18330	COG0457	Tetratricopeptide repeat
HGH94_18335	COG1132	(ABC) transporter
HGH94_18355	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HGH94_18355	COG0140	phosphoribosyl-ATP diphosphatase activity
HGH94_18360	COG0107	imidazoleglycerol-phosphate synthase activity
HGH94_18365	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HGH94_18370	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HGH94_18375	COG0131	Imidazoleglycerol-phosphate dehydratase
HGH94_18380	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HGH94_18385	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HGH94_18395	COG4990	cell redox homeostasis
HGH94_18400	COG5297	Belongs to the glycosyl hydrolase family 6
HGH94_18405	COG0110	maltose O-acetyltransferase activity
HGH94_18410	COG0546	phosphoglycolate phosphatase activity
HGH94_18420	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HGH94_18425	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HGH94_18430	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HGH94_18435	COG0363	glucosamine-6-phosphate deaminase activity
HGH94_18440	COG2188	Transcriptional regulator
HGH94_18445	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HGH94_18450	COG1846	Transcriptional regulator
HGH94_18455	COG2124	cytochrome p450
HGH94_18465	COG1846	Transcriptional regulator
HGH94_18470	COG2814	Major facilitator Superfamily
HGH94_18475	COG1950	PFAM Membrane protein of
HGH94_18480	COG1983	PspC domain protein
HGH94_18485	COG3595	metallopeptidase activity
HGH94_18500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HGH94_18510	COG0556	nucleotide-excision repair
HGH94_18515	COG4897	Protein conserved in bacteria
HGH94_18520	COG3848	Pyruvate phosphate dikinase
HGH94_18520	COG0574	Belongs to the PEP-utilizing enzyme family
HGH94_18525	COG1309	transcriptional regulator
HGH94_18530	COG2814	Major facilitator Superfamily
HGH94_18535	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HGH94_18550	COG2177	Part of the ABC transporter FtsEX involved in
HGH94_18555	COG2884	Cell division ATP-binding protein ftsE
HGH94_18560	COG2010	Cytochrome c
HGH94_18565	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HGH94_18575	COG0653	protein targeting
HGH94_18595	COG1516	flagellar protein fliS
HGH94_18600	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HGH94_18605	COG1334	flagellar protein FlaG
HGH94_18610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HGH94_18620	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HGH94_18635	COG1256	bacterial-type flagellum assembly
HGH94_18635	COG4786	Flagellar basal body rod
HGH94_18640	COG3418	PFAM FlgN family protein
HGH94_18645	COG2747	anti-sigma28 factor FlgM
HGH94_18665	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HGH94_18670	COG1307	EDD domain protein, DegV family
HGH94_18675	COG2197	response regulator
HGH94_18680	COG4585	Histidine kinase
HGH94_18685	COG1739	Uncharacterized protein family UPF0029
HGH94_18690	COG1316	TRANSCRIPTIONal
HGH94_18695	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HGH94_18700	COG0438	transferase activity, transferring glycosyl groups
HGH94_18705	COG1215	transferase activity, transferring glycosyl groups
HGH94_18710	COG3206	protein involved in exopolysaccharide biosynthesis
HGH94_18715	COG3307	-O-antigen
HGH94_18720	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HGH94_18730	COG2244	polysaccharide biosynthetic process
HGH94_18740	COG2247	cell wall binding repeat
HGH94_18740	COG0860	N-Acetylmuramoyl-L-alanine amidase
HGH94_18745	COG2247	cell wall binding repeat
HGH94_18745	COG2385	sporulation resulting in formation of a cellular spore
HGH94_18755	COG1316	TRANSCRIPTIONal
HGH94_18760	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HGH94_18765	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HGH94_18775	COG1215	transferase activity, transferring glycosyl groups
HGH94_18775	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HGH94_18780	COG0463	Glycosyl transferase, family 2
HGH94_18790	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HGH94_18800	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HGH94_18805	COG1134	teichoic acid transport
HGH94_18810	COG1682	transport, permease protein
HGH94_18815	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HGH94_18820	COG0438	transferase activity, transferring glycosyl groups
HGH94_18825	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HGH94_18830	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HGH94_18845	COG4193	domain, Protein
HGH94_18850	COG1482	cell wall glycoprotein biosynthetic process
HGH94_18855	COG0697	spore germination
HGH94_18860	COG0814	amino acid
HGH94_18875	COG1316	TRANSCRIPTIONal
HGH94_18880	COG0561	phosphatase activity
HGH94_18890	COG0791	NLP P60 protein
HGH94_18900	COG2843	Capsule synthesis protein
HGH94_18910	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HGH94_18915	COG1609	Transcriptional regulator
HGH94_18920	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGH94_18925	COG1869	D-ribose catabolic process
HGH94_18930	COG1129	ABC transporter
HGH94_18935	COG1172	Belongs to the binding-protein-dependent transport system permease family
HGH94_18940	COG1879	ABC-type sugar transport system periplasmic component
HGH94_18945	COG3103	Sh3 type 3 domain protein
HGH94_18955	COG2249	NAD(P)H dehydrogenase (quinone) activity
HGH94_18960	COG3527	Alpha-acetolactate decarboxylase
HGH94_18965	COG0028	Belongs to the TPP enzyme family
HGH94_18970	COG0583	DNA-binding transcription factor activity
HGH94_18990	COG5337	Spore coat protein CotH
HGH94_19000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HGH94_19010	COG0405	Gamma-glutamyltransferase
HGH94_19015	COG1522	sequence-specific DNA binding
HGH94_19025	COG2059	Chromate
HGH94_19035	COG0655	NAD(P)H dehydrogenase (quinone) activity
HGH94_19040	COG0583	DNA-binding transcription factor activity
HGH94_19090	COG3878	Protein conserved in bacteria
HGH94_19095	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HGH94_19100	COG4464	protein tyrosine phosphatase activity
HGH94_19105	COG0489	protein tyrosine kinase activity
HGH94_19110	COG3944	biosynthesis protein
HGH94_19120	COG4715	Zinc finger, swim domain protein
HGH94_19125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HGH94_19130	COG0561	phosphatase activity
HGH94_19135	COG1349	DNA-binding transcription factor activity
HGH94_19140	COG0629	single-stranded DNA binding
HGH94_19155	COG3764	Sortase (surface protein transpeptidase)
HGH94_19165	COG2972	Histidine kinase
HGH94_19165	COG0745	RESPONSE REGULATOR receiver
HGH94_19170	COG1970	mechanosensitive ion channel activity
HGH94_19175	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HGH94_19180	COG0457	Tetratricopeptide repeat
HGH94_19185	COG4786	Flagellar basal body rod
HGH94_19190	COG4786	Flagellar basal body rod
HGH94_19200	COG1609	Transcriptional regulator
HGH94_19210	COG1846	Transcriptional regulator
HGH94_19215	COG2814	Major facilitator Superfamily
HGH94_19220	COG3420	alginic acid biosynthetic process
HGH94_19225	COG1953	Uracil, thiamine, allantoin
HGH94_19230	COG0477	Major facilitator Superfamily
HGH94_19235	COG1335	isochorismatase
HGH94_19245	COG0004	ammonium transporteR
HGH94_19250	COG0347	Belongs to the P(II) protein family
HGH94_19265	COG0739	heme binding
HGH94_19270	COG1247	-acetyltransferase
HGH94_19295	COG0789	Transcriptional regulator
HGH94_19305	COG2910	NAD(P)H-binding
HGH94_19310	COG1959	2 iron, 2 sulfur cluster binding
HGH94_19315	COG0804	urea catabolic process
HGH94_19320	COG0832	Belongs to the urease beta subunit family
HGH94_19325	COG0831	urea catabolic process
HGH94_19355	COG3237	CsbD-like
HGH94_19360	COG1994	Peptidase M50
HGH94_19370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HGH94_19375	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HGH94_19385	COG2304	oxidoreductase activity
HGH94_19395	COG2304	oxidoreductase activity
HGH94_19400	COG2385	sporulation resulting in formation of a cellular spore
HGH94_19405	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HGH94_19415	COG4836	Membrane
HGH94_19425	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HGH94_19430	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HGH94_19435	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HGH94_19440	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HGH94_19445	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HGH94_19450	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HGH94_19460	COG0356	it plays a direct role in the translocation of protons across the membrane
HGH94_19470	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HGH94_19475	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HGH94_19480	COG4475	Protein of unknown function (DUF436)
HGH94_19485	COG0698	ribose 5-phosphate isomerase
HGH94_19490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HGH94_19495	COG1971	Probably functions as a manganese efflux pump
HGH94_19500	COG0009	L-threonylcarbamoyladenylate synthase
HGH94_19505	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HGH94_19525	COG2890	protein-(glutamine-N5) methyltransferase activity
HGH94_19530	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HGH94_19535	COG0346	lactoylglutathione lyase activity
HGH94_19540	COG0789	Transcriptional regulator
HGH94_19545	COG0679	Auxin Efflux Carrier
HGH94_19550	COG0281	malic enzyme
HGH94_19555	COG1435	thymidine kinase activity
HGH94_19565	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HGH94_19575	COG1494	fructose-1,6-bisphosphatase
HGH94_19580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HGH94_19585	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HGH94_19590	COG0191	fructose-bisphosphate aldolase activity
HGH94_19595	COG2204	response regulator
HGH94_19600	COG4821	SIS domain
HGH94_19610	COG2801	Transposase and inactivated derivatives
HGH94_19615	COG0504	CTP synthase activity
HGH94_19620	COG3343	RNA polymerase activity
HGH94_19625	COG1960	acyl-CoA dehydrogenase activity
HGH94_19630	COG2181	nitrate reductase activity
HGH94_19630	COG0247	lactate metabolic process
HGH94_19640	COG4294	response to UV
HGH94_19650	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HGH94_19655	COG1132	(ABC) transporter
HGH94_19660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HGH94_19670	COG2181	nitrate reductase activity
HGH94_19675	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HGH94_19685	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HGH94_19690	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HGH94_19700	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HGH94_19705	COG2223	nitrite transmembrane transporter activity
HGH94_19710	COG0018	arginyl-trna synthetase
HGH94_19715	COG4506	Protein conserved in bacteria
HGH94_19730	COG0535	radical SAM domain protein
HGH94_19740	COG1131	(ABC) transporter
HGH94_19745	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HGH94_19750	COG0612	Peptidase, M16
HGH94_19755	COG0612	Peptidase, M16
HGH94_19780	COG0457	Tetratricopeptide repeat
HGH94_19795	COG0010	Belongs to the arginase family
HGH94_19800	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HGH94_19805	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HGH94_19815	COG1994	Peptidase M50
HGH94_19820	COG1942	4-Oxalocrotonate Tautomerase
HGH94_19825	COG1846	Transcriptional regulator
HGH94_19830	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HGH94_19840	COG0477	Major facilitator Superfamily
HGH94_19845	COG1959	2 iron, 2 sulfur cluster binding
HGH94_19850	COG3465	dGTPase activity
HGH94_19855	COG1078	dGTPase activity
HGH94_19860	COG4844	belongs to the
HGH94_19870	COG0697	spore germination
HGH94_19875	COG0095	Lipoate-protein ligase
HGH94_19880	COG0583	DNA-binding transcription factor activity
HGH94_19885	COG0280	phosphate acetyltransferase
HGH94_19895	COG1028	Short-chain dehydrogenase reductase Sdr
HGH94_19910	COG1028	Short-chain dehydrogenase reductase Sdr
HGH94_19930	COG0833	amino acid
HGH94_19935	COG4187	Peptidase family M20/M25/M40
HGH94_19940	COG1012	belongs to the aldehyde dehydrogenase family
HGH94_19955	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HGH94_19960	COG1091	dTDP-4-dehydrorhamnose reductase activity
HGH94_19965	COG1088	dTDP-glucose 4,6-dehydratase activity
HGH94_19970	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HGH94_19975	COG3980	spore coat polysaccharide biosynthesis protein
HGH94_19980	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HGH94_19985	COG2089	acid synthase
HGH94_19990	COG0456	acetyltransferase
HGH94_20000	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HGH94_20005	COG0463	Glycosyl transferase, family 2
HGH94_20015	COG2363	Small membrane protein
HGH94_20030	COG1012	belongs to the aldehyde dehydrogenase family
HGH94_20035	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HGH94_20055	COG1695	Transcriptional regulator
HGH94_20060	COG0351	phosphomethylpyrimidine kinase
HGH94_20070	COG1621	beta-fructofuranosidase activity
HGH94_20075	COG1263	PTS System
HGH94_20075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HGH94_20080	COG2116	formate transmembrane transporter activity
HGH94_20085	COG3711	transcriptional antiterminator
HGH94_20100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGH94_20105	COG0778	Nitroreductase
HGH94_20110	COG0772	Belongs to the SEDS family
HGH94_20120	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HGH94_20125	COG1845	cytochrome c oxidase, subunit III
HGH94_20130	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HGH94_20135	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HGH94_20140	COG2261	transglycosylase associated protein
HGH94_20150	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HGH94_20155	COG2246	polysaccharide biosynthetic process
HGH94_20160	COG1309	transcriptional regulator
HGH94_20170	COG3162	membrane
HGH94_20175	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HGH94_20185	COG2837	iron assimilation
HGH94_20190	COG2822	iron ion transport
HGH94_20195	COG0672	)-iron permease
HGH94_20200	COG0352	thiamine-phosphate diphosphorylase activity
HGH94_20205	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HGH94_20215	COG1380	Effector of murein hydrolase LrgA
HGH94_20220	COG1346	cytolysis
HGH94_20225	COG2814	Major facilitator Superfamily
HGH94_20230	COG4895	conserved protein (DUF2196)
HGH94_20235	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HGH94_20240	COG0346	lactoylglutathione lyase activity
HGH94_20250	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HGH94_20255	COG1404	Belongs to the peptidase S8 family
HGH94_20260	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HGH94_20260	COG1263	PTS System
HGH94_20265	COG3711	transcriptional antiterminator
HGH94_20270	COG1442	glycosyl transferase family 8
HGH94_20280	COG1846	Transcriptional regulator
HGH94_20290	COG2234	aminopeptidase activity
HGH94_20310	COG2814	Major facilitator Superfamily
HGH94_20315	COG2357	RelA SpoT domain protein
HGH94_20320	COG1575	Belongs to the MenA family. Type 1 subfamily
HGH94_20340	COG1696	Membrane protein involved in D-alanine export
HGH94_20345	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HGH94_20350	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HGH94_20355	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HGH94_20360	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HGH94_20365	COG1486	melibiose metabolic process
HGH94_20370	COG1447	Phosphotransferase system cellobiose-specific component IIA
HGH94_20380	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HGH94_20385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HGH94_20385	COG3711	transcriptional antiterminator
HGH94_20395	COG2094	Belongs to the DNA glycosylase MPG family
HGH94_20400	COG0753	catalase activity
HGH94_20410	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HGH94_20415	COG1131	(ABC) transporter
HGH94_20435	COG1595	DNA-templated transcription, initiation
HGH94_20440	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HGH94_20450	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HGH94_20455	COG4988	ABC transporter
HGH94_20460	COG1294	oxidase, subunit
HGH94_20465	COG1271	oxidase subunit
HGH94_20470	COG3493	citrate carrier protein
HGH94_20475	COG0501	Belongs to the peptidase M48B family
HGH94_20485	COG0726	polysaccharide deacetylase
HGH94_20490	COG3842	ATPase activity
HGH94_20495	COG2508	Transcriptional regulator
HGH94_20500	COG1012	belongs to the aldehyde dehydrogenase family
HGH94_20505	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HGH94_20515	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HGH94_20525	COG4585	Histidine kinase
HGH94_20530	COG2197	response regulator
HGH94_20535	COG2195	Cleaves the N-terminal amino acid of tripeptides
HGH94_20545	COG4894	glucomannan catabolic process
HGH94_20550	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HGH94_20555	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HGH94_20565	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HGH94_20570	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HGH94_20575	COG2610	gluconate transmembrane transporter activity
HGH94_20580	COG0500	methyltransferase
HGH94_20585	COG2323	membrane
HGH94_20600	COG2323	membrane
HGH94_20635	COG3546	catalase activity
HGH94_20680	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HGH94_20695	COG0693	protein deglycase activity
HGH94_20695	COG0753	catalase activity
HGH94_20705	COG2273	Hydrolase Family 16
HGH94_20720	COG2270	Major facilitator Superfamily
HGH94_20725	COG0513	Belongs to the DEAD box helicase family
HGH94_20835	COG0697	spore germination
HGH94_20840	COG0589	response to stress
HGH94_20860	COG5444	nuclease activity
HGH94_20895	COG3507	Belongs to the glycosyl hydrolase 43 family
HGH94_20910	COG2986	histidine ammonia-lyase
HGH94_20915	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HGH94_20920	COG1228	amidohydrolase
HGH94_20925	COG0010	Belongs to the arginase family
HGH94_20930	COG0833	amino acid
HGH94_20935	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HGH94_20940	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HGH94_20945	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HGH94_20950	COG2390	Transcriptional regulator
HGH94_20965	COG2079	MmgE PrpD family protein
HGH94_20970	COG1473	amidohydrolase
HGH94_20975	COG1126	abc transporter atp-binding protein
HGH94_20980	COG0765	amino acid transport
HGH94_20985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HGH94_20990	COG0456	acetyltransferase
HGH94_20995	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HGH94_21000	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HGH94_21005	COG0561	phosphatase activity
HGH94_21035	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HGH94_21040	COG5294	Protein conserved in bacteria
HGH94_21045	COG0577	efflux transmembrane transporter activity
HGH94_21050	COG1136	(ABC) transporter
HGH94_21055	COG2205	protein histidine kinase activity
HGH94_21060	COG0745	RESPONSE REGULATOR receiver
HGH94_21065	COG0191	fructose-bisphosphate aldolase activity
HGH94_21070	COG1082	Xylose isomerase domain protein TIM barrel
HGH94_21075	COG1082	Xylose isomerase domain protein TIM barrel
HGH94_21080	COG0673	inositol 2-dehydrogenase activity
HGH94_21085	COG2814	Major facilitator Superfamily
HGH94_21090	COG1082	Xylose isomerase domain protein TIM barrel
HGH94_21095	COG3962	Belongs to the TPP enzyme family
HGH94_21100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HGH94_21105	COG3718	enzyme involved in inositol metabolism
HGH94_21110	COG1012	belongs to the aldehyde dehydrogenase family
HGH94_21115	COG1349	DNA-binding transcription factor activity
HGH94_21120	COG0667	Aldo Keto reductase
HGH94_21135	COG2814	Major facilitator Superfamily
HGH94_21140	COG0326	Molecular chaperone. Has ATPase activity
HGH94_21150	COG1028	Short-chain dehydrogenase reductase Sdr
HGH94_21155	COG1309	transcriptional regulator
HGH94_21160	COG1012	belongs to the aldehyde dehydrogenase family
HGH94_21170	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HGH94_21180	COG1714	RDD family
HGH94_21185	COG2311	Membrane
HGH94_21190	COG1917	Cupin 2, conserved barrel domain protein
HGH94_21195	COG1309	transcriptional regulator
HGH94_21200	COG1028	Short-chain dehydrogenase reductase Sdr
HGH94_21210	COG1846	Transcriptional regulator
HGH94_21215	COG1380	Effector of murein hydrolase LrgA
HGH94_21220	COG1346	cytolysis
HGH94_21230	COG5039	Polysaccharide pyruvyl transferase
HGH94_21235	COG1929	Belongs to the glycerate kinase type-1 family
HGH94_21245	COG1070	Carbohydrate kinase
HGH94_21250	COG2610	gluconate transmembrane transporter activity
HGH94_21260	COG0450	alkyl hydroperoxide reductase
HGH94_21265	COG3634	alkyl hydroperoxide reductase activity
HGH94_21270	COG2723	6-phospho-beta-galactosidase activity
HGH94_21280	COG2188	Transcriptional regulator
HGH94_21290	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HGH94_21340	COG1063	alcohol dehydrogenase
HGH94_21360	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HGH94_21365	COG0456	acetyltransferase
HGH94_21370	COG0457	Tetratricopeptide repeat
HGH94_21380	COG0010	Belongs to the arginase family
HGH94_21385	COG0833	amino acid
HGH94_21390	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HGH94_21395	COG3829	transcription factor binding
HGH94_21410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HGH94_21415	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HGH94_21420	COG4853	Protein conserved in bacteria
HGH94_21425	COG4863	YycH protein
HGH94_21435	COG0745	RESPONSE REGULATOR receiver
HGH94_21470	COG0305	Participates in initiation and elongation during chromosome replication
HGH94_21485	COG3093	addiction module antidote protein HigA
HGH94_21490	COG2807	transmembrane transport
HGH94_21495	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HGH94_21500	COG0359	binds to the 23S rRNA
HGH94_21505	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HGH94_21510	COG4241	membrane
HGH94_21525	COG1733	regulation of RNA biosynthetic process
HGH94_21530	COG1227	inorganic diphosphatase activity
HGH94_21550	COG4978	Transcriptional regulator
HGH94_21550	COG0789	Transcriptional regulator
HGH94_21560	COG4319	ketosteroid isomerase
HGH94_21565	COG1357	PFAM Pentapeptide repeats (8 copies)
HGH94_21580	COG1846	Transcriptional regulator
HGH94_21585	COG2153	protein acetylation
HGH94_21590	COG2364	Membrane
HGH94_21595	COG0456	acetyltransferase
HGH94_21600	COG2315	Protein conserved in bacteria
HGH94_21605	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HGH94_21615	COG2814	Major facilitator Superfamily
HGH94_21625	COG1331	Highly conserved protein containing a thioredoxin domain
HGH94_21630	COG1266	CAAX protease self-immunity
HGH94_21640	COG0110	maltose O-acetyltransferase activity
HGH94_21645	COG0346	lactoylglutathione lyase activity
HGH94_21650	COG1609	Transcriptional regulator
HGH94_21655	COG0708	Exodeoxyribonuclease III
HGH94_21660	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HGH94_21670	COG0360	Binds together with S18 to 16S ribosomal RNA
HGH94_21675	COG0012	GTP binding
HGH94_21680	COG0243	molybdopterin cofactor binding
HGH94_21685	COG4481	Protein conserved in bacteria
HGH94_21690	COG3949	Membrane
HGH94_21700	COG1475	DNA binding
HGH94_21715	COG1475	DNA binding
HGH94_21720	COG0357	Ribosomal RNA small subunit methyltransferase G
HGH94_21725	COG0445	tRNA wobble uridine modification
HGH94_21730	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HGH94_21735	COG1847	R3H domain protein
HGH94_21745	COG0594	ribonuclease P activity