locus-tag	class	description
NP435_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
NP435_00010	COG0592	DNA-directed DNA polymerase activity
NP435_00015	COG2501	S4 domain
NP435_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
NP435_00030	COG0187	DNA topoisomerase II activity
NP435_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NP435_00070	COG0516	GMP reductase activity
NP435_00070	COG0517	IMP dehydrogenase activity
NP435_00075	COG1686	Belongs to the peptidase S11 family
NP435_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
NP435_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
NP435_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
NP435_00100	COG1428	Deoxynucleoside kinase
NP435_00105	COG1428	Deoxynucleoside kinase
NP435_00110	COG1388	LysM domain
NP435_00110	COG3858	chitin binding
NP435_00115	COG1335	isochorismatase
NP435_00120	COG0590	tRNA wobble adenosine to inosine editing
NP435_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
NP435_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
NP435_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
NP435_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
NP435_00190	COG3853	Toxic anion resistance protein (TelA)
NP435_00195	COG1982	Orn Lys Arg decarboxylase major
NP435_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NP435_00205	COG3870	Protein conserved in bacteria
NP435_00210	COG1728	Protein conserved in bacteria
NP435_00215	COG0470	DNA polymerase III
NP435_00220	COG1774	PSP1 C-terminal conserved region
NP435_00225	COG4467	Involved in initiation control of chromosome replication
NP435_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
NP435_00235	COG2827	Endonuclease containing a URI domain
NP435_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
NP435_00245	COG2002	toxin-antitoxin pair type II binding
NP435_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP435_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP435_00255	COG0084	hydrolase, TatD family'
NP435_00260	COG3584	3D domain protein
NP435_00260	COG3583	domain protein
NP435_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NP435_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
NP435_00280	COG4466	Protein conserved in bacteria
NP435_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
NP435_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NP435_00300	COG0251	oxidation-reduction process
NP435_00305	COG2088	sporulation resulting in formation of a cellular spore
NP435_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
NP435_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
NP435_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
NP435_00325	COG0193	aminoacyl-tRNA hydrolase activity
NP435_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
NP435_00340	COG2002	toxin-antitoxin pair type II binding
NP435_00345	COG2244	polysaccharide biosynthetic process
NP435_00350	COG3956	TIGRFAM MazG family protein
NP435_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
NP435_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
NP435_00375	COG1098	S1 RNA binding domain
NP435_00390	COG2208	phosphoserine phosphatase activity
NP435_00395	COG2304	oxidoreductase activity
NP435_00400	COG0515	serine threonine protein kinase
NP435_00405	COG0037	tRNA processing
NP435_00410	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
NP435_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NP435_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
NP435_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
NP435_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NP435_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NP435_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NP435_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
NP435_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP435_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
NP435_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
NP435_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
NP435_00470	COG1396	sequence-specific DNA binding
NP435_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NP435_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
NP435_00560	COG4463	regulation of RNA biosynthetic process
NP435_00565	COG3880	PFAM UvrB UvrC protein
NP435_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
NP435_00575	COG0542	response to heat
NP435_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
NP435_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
NP435_00590	COG4956	integral membrane protein (PIN domain superfamily)
NP435_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
NP435_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
NP435_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
NP435_00610	COG1045	serine acetyltransferase
NP435_00615	COG0215	cysteine-tRNA ligase activity
NP435_00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
NP435_00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NP435_00630	COG3688	RNA-binding protein containing a PIN domain
NP435_00635	COG1595	DNA-templated transcription, initiation
NP435_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NP435_00650	COG0250	Participates in transcription elongation, termination and antitermination
NP435_00660	COG0081	regulation of translation
NP435_00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
NP435_00675	COG2813	Specifically methylates the guanine in position
NP435_00680	COG0085	RNA polymerase activity
NP435_00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
NP435_00690	COG1358	cellular component organization or biogenesis
NP435_00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
NP435_00700	COG0049	tRNA binding
NP435_00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
NP435_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
NP435_00715	COG0596	Alpha beta hydrolase
NP435_00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
NP435_00730	COG0088	Forms part of the polypeptide exit tunnel
NP435_00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
NP435_00755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
NP435_00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
NP435_00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
NP435_00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
NP435_00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
NP435_00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
NP435_00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
NP435_00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
NP435_00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
NP435_00820	COG0200	Binds to the 23S rRNA
NP435_00825	COG0201	protein transport
NP435_00830	COG0563	adenylate kinase activity
NP435_00835	COG0024	Methionine aminopeptidase
NP435_00840	COG2163	COG2163 Ribosomal protein L14E L6E L27E
NP435_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
NP435_00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
NP435_00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
NP435_00865	COG0202	RNA polymerase activity
NP435_00870	COG0203	ribosomal protein L17
NP435_00875	COG1122	ATPase activity
NP435_00880	COG1122	ATPase activity
NP435_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NP435_00890	COG0101	tRNA pseudouridine synthase activity
NP435_00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
NP435_00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
NP435_00905	COG2226	methyltransferase
NP435_00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP435_00920	COG0489	protein tyrosine kinase activity
NP435_00930	COG2194	sulfuric ester hydrolase activity
NP435_00935	COG0726	polysaccharide deacetylase
NP435_01015	COG0659	secondary active sulfate transmembrane transporter activity
NP435_01020	COG0385	Bile acid
NP435_01025	COG2819	hydrolase of the alpha beta superfamily
NP435_01030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP435_01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP435_01040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP435_01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP435_01045	COG2207	Transcriptional regulator
NP435_01050	COG3876	Protein conserved in bacteria
NP435_01055	COG1472	Belongs to the glycosyl hydrolase 3 family
NP435_01060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NP435_01065	COG1263	PTS System
NP435_01065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP435_01070	COG1737	Transcriptional regulator
NP435_01075	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
NP435_01080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP435_01085	COG1683	Conserved Protein
NP435_01115	COG1595	DNA-templated transcription, initiation
NP435_01120	COG5662	AntiSigma factor
NP435_01125	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NP435_01130	COG4856	YbbR-like protein
NP435_01135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NP435_01140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
NP435_01150	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NP435_01155	COG2169	Transcriptional regulator
NP435_01160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NP435_01165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NP435_01170	COG3002	Belongs to the UPF0753 family
NP435_01175	COG0288	reversible hydration of carbon dioxide
NP435_01185	COG5609	conserved protein (DUF2294)
NP435_01190	COG0640	Transcriptional regulator
NP435_01195	COG2814	Major facilitator Superfamily
NP435_01210	COG0535	radical SAM domain protein
NP435_01215	COG1266	CAAX protease self-immunity
NP435_01220	COG1131	(ABC) transporter
NP435_01230	COG1413	lyase activity
NP435_01235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP435_01240	COG0596	Alpha beta hydrolase
NP435_01245	COG0745	RESPONSE REGULATOR receiver
NP435_01250	COG0642	Histidine kinase
NP435_01260	COG0515	serine threonine protein kinase
NP435_01275	COG1113	amino acid transport
NP435_01290	COG2602	Beta-lactamase
NP435_01295	COG2124	cytochrome p450
NP435_01305	COG0531	amino acid
NP435_01310	COG0584	glycerophosphoryl diester phosphodiesterase
NP435_01315	COG2271	Major facilitator Superfamily
NP435_01325	COG0456	acetyltransferase
NP435_01325	COG1846	Transcriptional regulator
NP435_01330	COG2271	Major facilitator Superfamily
NP435_01340	COG3409	Peptidoglycan-binding domain 1 protein
NP435_01345	COG0697	spore germination
NP435_01350	COG1917	Cupin 2, conserved barrel domain protein
NP435_01350	COG2207	Transcriptional regulator
NP435_01355	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
NP435_01360	COG3591	Belongs to the peptidase S1B family
NP435_01370	COG0596	Alpha beta hydrolase
NP435_01375	COG1183	phosphatidylcholine synthase activity
NP435_01380	COG0586	Pfam SNARE associated Golgi protein
NP435_01385	COG0688	phosphatidylethanolamine metabolic process
NP435_01395	COG2312	Erythromycin esterase
NP435_01400	COG2207	Transcriptional regulator
NP435_01405	COG1054	Belongs to the UPF0176 family
NP435_01410	COG1301	dicarboxylic acid transport
NP435_01415	COG1263	PTS System
NP435_01415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP435_01415	COG2190	(PTS) system
NP435_01420	COG0363	glucosamine-6-phosphate deaminase activity
NP435_01425	COG2188	Transcriptional regulator
NP435_01435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP435_01440	COG0833	amino acid
NP435_01445	COG2040	homocysteine
NP435_01450	COG1115	amino acid carrier protein
NP435_01455	COG2066	Belongs to the glutaminase family
NP435_01460	COG4191	Histidine kinase
NP435_01465	COG0784	Response regulator, receiver
NP435_01470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NP435_01475	COG1012	belongs to the aldehyde dehydrogenase family
NP435_01480	COG2271	Major facilitator Superfamily
NP435_01485	COG4948	Mandelate Racemase Muconate Lactonizing
NP435_01490	COG2186	Transcriptional regulator
NP435_01495	COG2721	sulfolactate sulfo-lyase activity
NP435_01500	COG3173	Aminoglycoside phosphotransferase
NP435_01510	COG0697	spore germination
NP435_01515	COG0745	RESPONSE REGULATOR receiver
NP435_01520	COG2205	protein histidine kinase activity
NP435_01525	COG1131	(ABC) transporter
NP435_01545	COG3773	Cell wall hydrolase
NP435_01550	COG2304	oxidoreductase activity
NP435_01560	COG3540	Alkaline phosphatase
NP435_01565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NP435_01570	COG0805	protein transport
NP435_01575	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
NP435_01580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NP435_01585	COG0477	Major facilitator Superfamily
NP435_01590	COG1309	transcriptional regulator
NP435_01595	COG0252	asparaginase activity
NP435_01600	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NP435_01605	COG1714	RDD family
NP435_01610	COG1405	negative regulation of cell septum assembly
NP435_01610	COG3012	SEC-C Motif Domain Protein
NP435_01615	COG3290	protein histidine kinase activity
NP435_01620	COG3279	Response regulator of the LytR AlgR family
NP435_01625	COG4555	ABC transporter
NP435_01630	COG1668	transmembrane transport
NP435_01635	COG0667	Aldo Keto reductase
NP435_01650	COG1595	DNA-templated transcription, initiation
NP435_01655	COG1595	DNA-templated transcription, initiation
NP435_01660	COG1876	peptidase activity
NP435_01665	COG0457	Tetratricopeptide repeat
NP435_01670	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_01675	COG0366	Alpha amylase catalytic
NP435_01680	COG0803	Belongs to the bacterial solute-binding protein 9 family
NP435_01685	COG1121	(ABC) transporter
NP435_01690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NP435_01695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP435_01700	COG2310	stress, protein
NP435_01705	COG2310	stress, protein
NP435_01710	COG2310	stress, protein
NP435_01715	COG0861	Integral membrane protein TerC family
NP435_01725	COG3853	Toxic anion resistance protein (TelA)
NP435_01730	COG0477	Major facilitator Superfamily
NP435_01735	COG2814	Major facilitator Superfamily
NP435_01740	COG0640	Transcriptional regulator
NP435_01745	COG0517	IMP dehydrogenase activity
NP435_01745	COG4175	Glycine betaine
NP435_01750	COG4176	ABC-type proline glycine betaine transport system permease component
NP435_01755	COG2113	Glycine betaine
NP435_01760	COG1473	amidohydrolase
NP435_01765	COG1288	antiporter activity
NP435_01775	COG0366	Alpha amylase catalytic
NP435_01780	COG0039	L-malate dehydrogenase activity
NP435_01785	COG1620	l-lactate permease
NP435_01790	COG2814	Major facilitator Superfamily
NP435_01795	COG1846	Transcriptional regulator
NP435_01800	COG1280	lysine exporter protein (LysE YggA)
NP435_01805	COG3403	YqcI/YcgG family
NP435_01810	COG1113	amino acid transport
NP435_01815	COG3665	Urea carboxylase-associated protein
NP435_01820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
NP435_01825	COG1660	Displays ATPase and GTPase activities
NP435_01830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
NP435_01835	COG2226	methyltransferase
NP435_01840	COG0583	DNA-binding transcription factor activity
NP435_01845	COG3458	cephalosporin-C deacetylase activity
NP435_01850	COG3541	Predicted nucleotidyltransferase
NP435_01855	COG0506	proline dehydrogenase activity
NP435_01860	COG1012	belongs to the aldehyde dehydrogenase family
NP435_01865	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP435_01870	COG2508	Transcriptional regulator
NP435_01875	COG3689	TIGRFAM TIGR03943 family protein
NP435_01880	COG0701	Predicted permease
NP435_01885	COG2267	carboxylic ester hydrolase activity
NP435_01890	COG0492	ferredoxin-NADP+ reductase activity
NP435_01895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NP435_01895	COG1587	Uroporphyrinogen-III synthase
NP435_01900	COG2146	nitrite reductase [NAD(P)H] activity
NP435_01905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NP435_01910	COG0243	molybdopterin cofactor binding
NP435_01915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NP435_01920	COG2223	nitrite transmembrane transporter activity
NP435_01925	COG1469	GTP cyclohydrolase I activity
NP435_01930	COG1376	ErfK ybiS ycfS ynhG family protein
NP435_01940	COG0523	cobalamin synthesis protein
NP435_01945	COG0765	amino acid transport
NP435_01950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP435_01960	COG1714	RDD family
NP435_01970	COG2723	6-phospho-beta-galactosidase activity
NP435_01980	COG3209	COG3209 Rhs family protein
NP435_01985	COG0840	transmembrane signaling receptor activity
NP435_01985	COG3290	protein histidine kinase activity
NP435_01990	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
NP435_01995	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
NP435_02000	COG1733	regulation of RNA biosynthetic process
NP435_02005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP435_02025	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP435_02030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP435_02035	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
NP435_02040	COG2814	Major facilitator Superfamily
NP435_02050	COG0697	spore germination
NP435_02055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP435_02065	COG2364	Membrane
NP435_02070	COG1126	abc transporter atp-binding protein
NP435_02075	COG0765	amino acid transport
NP435_02080	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP435_02085	COG0583	DNA-binding transcription factor activity
NP435_02090	COG0163	prenyltransferase activity
NP435_02095	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
NP435_02110	COG0596	Alpha beta hydrolase
NP435_02115	COG3104	oligopeptide transport
NP435_02120	COG5434	Belongs to the glycosyl hydrolase 28 family
NP435_02130	COG0697	spore germination
NP435_02140	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NP435_02145	COG1136	(ABC) transporter
NP435_02150	COG0577	efflux transmembrane transporter activity
NP435_02155	COG0745	RESPONSE REGULATOR receiver
NP435_02160	COG3850	Histidine kinase
NP435_02160	COG5002	protein histidine kinase activity
NP435_02165	COG0457	Tetratricopeptide repeat
NP435_02185	COG0527	aspartate kinase activity
NP435_02190	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP435_02195	COG4605	iron ion homeostasis
NP435_02200	COG4604	ABC transporter, ATP-binding protein
NP435_02205	COG4607	ABC-type enterochelin transport system periplasmic component
NP435_02210	COG2814	Major facilitator Superfamily
NP435_02215	COG1309	transcriptional regulator
NP435_02220	COG0778	Nitroreductase
NP435_02225	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NP435_02230	COG0640	Transcriptional regulator
NP435_02235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP435_02240	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
NP435_02245	COG1012	belongs to the aldehyde dehydrogenase family
NP435_02250	COG4975	Glucose uptake
NP435_02255	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_02260	COG4549	nuclear export factor GLE1
NP435_02265	COG1276	copper resistance
NP435_02265	COG2372	response to copper ion
NP435_02270	COG1349	DNA-binding transcription factor activity
NP435_02280	COG2213	PTS system mannitol-specific
NP435_02285	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP435_02290	COG0246	Mannitol dehydrogenase
NP435_02295	COG0473	3-isopropylmalate dehydrogenase activity
NP435_02300	COG0681	Belongs to the peptidase S26 family
NP435_02305	COG0412	Dienelactone hydrolase
NP435_02310	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NP435_02320	COG0561	phosphatase activity
NP435_02325	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
NP435_02330	COG1914	H( )-stimulated, divalent metal cation uptake system
NP435_02335	COG4336	lyase activity
NP435_02340	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
NP435_02345	COG1984	allophanate hydrolase subunit 2
NP435_02350	COG1414	Transcriptional regulator
NP435_02355	COG2755	lipolytic protein G-D-S-L family
NP435_02365	COG2329	Antibiotic biosynthesis monooxygenase
NP435_02370	COG0768	penicillin binding
NP435_02375	COG4989	oxidoreductase activity
NP435_02380	COG3711	transcriptional antiterminator
NP435_02385	COG0318	PFAM AMP-dependent synthetase and ligase
NP435_02390	COG2226	methyltransferase
NP435_02395	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_02400	COG1917	Cupin 2, conserved barrel domain protein
NP435_02405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP435_02410	COG3871	stress protein (general stress protein 26)
NP435_02420	COG2814	Major facilitator Superfamily
NP435_02425	COG1522	sequence-specific DNA binding
NP435_02430	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NP435_02430	COG0551	DNA topoisomerase type I activity
NP435_02435	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
NP435_02440	COG3706	GGDEF domain
NP435_02445	COG5298	Protein conserved in bacteria
NP435_02450	COG1215	transferase activity, transferring glycosyl groups
NP435_02460	COG0531	amino acid
NP435_02465	COG0494	nUDIX hydrolase
NP435_02470	COG0028	Belongs to the TPP enzyme family
NP435_02485	COG1914	H( )-stimulated, divalent metal cation uptake system
NP435_02490	COG2261	transglycosylase associated protein
NP435_02495	COG4876	unkown
NP435_02500	COG2217	Heavy metal translocating P-type atpase
NP435_02505	COG3729	General stress protein
NP435_02510	COG0662	Cupin 2, conserved barrel domain protein
NP435_02515	COG2329	Antibiotic biosynthesis monooxygenase
NP435_02520	COG3546	catalase activity
NP435_02525	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
NP435_02530	COG3290	protein histidine kinase activity
NP435_02535	COG4565	transcriptional regulatory protein
NP435_02540	COG1301	dicarboxylic acid transport
NP435_02545	COG0628	permease
NP435_02550	COG1131	(ABC) transporter
NP435_02555	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NP435_02565	COG1960	acyl-CoA dehydrogenase activity
NP435_02580	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NP435_02585	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP435_02590	COG1181	Belongs to the D-alanine--D-alanine ligase family
NP435_02595	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
NP435_02600	COG0513	Belongs to the DEAD box helicase family
NP435_02605	COG3402	PFAM membrane-flanked domain
NP435_02610	COG3428	Bacterial PH domain
NP435_02615	COG0705	Rhomboid family
NP435_02620	COG0736	holo-[acyl-carrier-protein] synthase activity
NP435_02625	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
NP435_02630	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NP435_02635	COG0864	Transcriptional regulator
NP435_02640	COG2337	Toxic component of a toxin-antitoxin (TA) module
NP435_02645	COG1366	Belongs to the anti-sigma-factor antagonist family
NP435_02650	COG1366	Belongs to the anti-sigma-factor antagonist family
NP435_02655	COG2172	sigma factor antagonist activity
NP435_02660	COG2208	phosphoserine phosphatase activity
NP435_02665	COG1366	Belongs to the anti-sigma-factor antagonist family
NP435_02670	COG2172	sigma factor antagonist activity
NP435_02675	COG1191	sigma factor activity
NP435_02680	COG2208	phosphoserine phosphatase activity
NP435_02700	COG1673	EVE domain
NP435_02705	COG1846	Transcriptional regulator
NP435_02710	COG2183	response to ionizing radiation
NP435_02720	COG3091	SprT-like family
NP435_02760	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP435_02765	COG1522	sequence-specific DNA binding
NP435_02770	COG1522	sequence-specific DNA binding
NP435_02775	COG1335	isochorismatase
NP435_02780	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NP435_02785	COG2814	Major facilitator Superfamily
NP435_02805	COG0693	protein deglycase activity
NP435_02810	COG1278	Cold shock
NP435_02815	COG1329	Transcriptional regulator
NP435_02830	COG1917	Cupin 2, conserved barrel domain protein
NP435_02830	COG2207	Transcriptional regulator
NP435_02835	COG0697	spore germination
NP435_02840	COG2207	Transcriptional regulator
NP435_02840	COG3708	Transcriptional regulator
NP435_02845	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP435_02850	COG0477	Major facilitator Superfamily
NP435_02860	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
NP435_02870	COG0697	spore germination
NP435_02875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP435_02880	COG2030	dehydratase
NP435_02885	COG3545	Serine hydrolase
NP435_02890	COG1733	regulation of RNA biosynthetic process
NP435_02895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP435_02900	COG1733	regulation of RNA biosynthetic process
NP435_02905	COG2249	NAD(P)H dehydrogenase (quinone) activity
NP435_02910	COG2814	Major facilitator Superfamily
NP435_02915	COG1309	transcriptional regulator
NP435_02920	COG0640	Transcriptional regulator
NP435_02925	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NP435_02935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP435_02940	COG0697	spore germination
NP435_02945	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP435_02950	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NP435_02955	COG0640	Transcriptional regulator
NP435_02960	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NP435_02975	COG4585	Histidine kinase
NP435_02980	COG2197	response regulator
NP435_02985	COG2409	Drug exporters of the RND superfamily
NP435_02990	COG0596	Alpha beta hydrolase
NP435_02995	COG1811	Na channel or pump
NP435_03000	COG0789	Transcriptional regulator
NP435_03000	COG4978	Transcriptional regulator
NP435_03005	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NP435_03010	COG0778	Nitroreductase
NP435_03015	COG0346	lactoylglutathione lyase activity
NP435_03020	COG2259	Doxx family
NP435_03025	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP435_03045	COG2323	membrane
NP435_03050	COG2323	membrane
NP435_03055	COG0071	Belongs to the small heat shock protein (HSP20) family
NP435_03070	COG1309	transcriptional regulator
NP435_03080	COG0456	acetyltransferase
NP435_03085	COG0488	(ABC) transporter
NP435_03090	COG1113	amino acid transport
NP435_03095	COG2318	DinB family
NP435_03100	COG1846	Transcriptional regulator
NP435_03105	COG1033	growth of symbiont in host cell
NP435_03105	COG2409	Drug exporters of the RND superfamily
NP435_03110	COG0778	Nitroreductase
NP435_03115	COG1846	Transcriptional regulator
NP435_03120	COG2814	Major facilitator Superfamily
NP435_03125	COG0730	response to heat
NP435_03130	COG1802	Transcriptional regulator
NP435_03135	COG3858	chitin binding
NP435_03135	COG1388	LysM domain
NP435_03140	COG1819	glycosyl
NP435_03150	COG1785	Belongs to the alkaline phosphatase family
NP435_03155	COG5646	InterPro IPR014922
NP435_03165	COG0454	-acetyltransferase
NP435_03170	COG1078	dGTPase activity
NP435_03175	COG1388	LysM domain
NP435_03180	COG2814	Major facilitator Superfamily
NP435_03185	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NP435_03190	COG1447	Phosphotransferase system cellobiose-specific component IIA
NP435_03195	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NP435_03200	COG2723	6-phospho-beta-galactosidase activity
NP435_03205	COG2188	Transcriptional regulator
NP435_03210	COG1940	carbohydrate kinase activity
NP435_03215	COG1482	cell wall glycoprotein biosynthetic process
NP435_03220	COG4124	Belongs to the glycosyl hydrolase 26 family
NP435_03265	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
NP435_03270	COG0802	atpase or kinase
NP435_03275	COG1214	PFAM Peptidase M22, glycoprotease
NP435_03280	COG0456	acetyltransferase
NP435_03285	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
NP435_03290	COG0488	(ABC) transporter
NP435_03295	COG0315	cyclic pyranopterin monophosphate synthase activity
NP435_03300	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
NP435_03305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NP435_03310	COG0805	protein transport
NP435_03320	COG1266	CAAX protease self-immunity
NP435_03330	COG0459	protein refolding
NP435_03345	COG3378	Phage plasmid primase P4 family
NP435_03360	COG0270	DNA (cytosine-5-)-methyltransferase activity
NP435_03365	COG0270	DNA (cytosine-5-)-methyltransferase activity
NP435_03380	COG1401	restriction endodeoxyribonuclease activity
NP435_03400	COG0457	Tetratricopeptide repeat
NP435_03405	COG1063	alcohol dehydrogenase
NP435_03410	COG2211	Major facilitator Superfamily
NP435_03415	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP435_03420	COG1842	Phage shock protein A
NP435_03425	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NP435_03430	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
NP435_03435	COG4260	virion core protein, lumpy skin disease virus
NP435_03445	COG2814	Major facilitator Superfamily
NP435_03450	COG1063	alcohol dehydrogenase
NP435_03455	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
NP435_03460	COG0823	Involved in the tonB-independent uptake of proteins
NP435_03475	COG2267	carboxylic ester hydrolase activity
NP435_03485	COG2132	Multicopper oxidase
NP435_03490	COG1113	amino acid transport
NP435_03500	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
NP435_03505	COG0714	Associated with various cellular activities
NP435_03510	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
NP435_03515	COG1305	Transglutaminase-like
NP435_03520	COG0519	Catalyzes the synthesis of GMP from XMP
NP435_03520	COG0518	GMP synthase (glutamine-hydrolyzing) activity
NP435_03525	COG2252	PERMEase
NP435_03530	COG3064	Membrane
NP435_03540	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
NP435_03550	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
NP435_03555	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
NP435_03560	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
NP435_03565	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
NP435_03570	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NP435_03575	COG0047	phosphoribosylformylglycinamidine synthase activity
NP435_03580	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
NP435_03585	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
NP435_03590	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
NP435_03595	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
NP435_03600	COG0138	bifunctional purine biosynthesis protein purh
NP435_03605	COG0151	Belongs to the GarS family
NP435_03610	COG1522	sequence-specific DNA binding
NP435_03615	COG0531	amino acid
NP435_03625	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NP435_03630	COG1470	cell adhesion involved in biofilm formation
NP435_03635	COG4496	protein, YerC YecD
NP435_03640	COG0069	glutamate synthase activity
NP435_03645	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
NP435_03650	COG0210	DNA helicase
NP435_03655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
NP435_03660	COG4851	CamS sex pheromone cAM373 precursor
NP435_03665	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NP435_03670	COG1285	pathogenesis
NP435_03675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP435_03680	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NP435_03685	COG0154	amidase activity
NP435_03690	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
NP435_03695	COG1309	transcriptional regulator
NP435_03700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
NP435_03705	COG1597	lipid kinase activity
NP435_03710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NP435_03715	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NP435_03720	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NP435_03725	COG1002	Type II restriction enzyme, methylase subunits
NP435_03730	COG1061	Type III restriction enzyme res subunit
NP435_03735	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NP435_03755	COG5444	nuclease activity
NP435_03760	COG3391	amine dehydrogenase activity
NP435_03765	COG0457	Tetratricopeptide repeat
NP435_03775	COG0217	transcriptional regulatory protein
NP435_03785	COG1309	transcriptional regulator
NP435_03790	COG3631	Ketosteroid isomerase-related protein
NP435_03795	COG0702	epimerase
NP435_03810	COG3546	catalase activity
NP435_03815	COG0454	-acetyltransferase
NP435_03825	COG5578	integral membrane protein
NP435_03830	COG2972	Histidine kinase
NP435_03835	COG2207	Transcriptional regulator
NP435_03835	COG4753	response regulator
NP435_03840	COG1653	transport
NP435_03845	COG1175	transmembrane transport
NP435_03850	COG0395	ABC-type sugar transport system, permease component
NP435_03855	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NP435_03860	COG2207	Transcriptional regulator
NP435_03865	COG2755	lipolytic protein G-D-S-L family
NP435_03875	COG5578	integral membrane protein
NP435_03880	COG3401	FG-GAP repeat protein
NP435_03885	COG3401	FG-GAP repeat protein
NP435_03890	COG2755	lipolytic protein G-D-S-L family
NP435_03895	COG1874	Beta-galactosidase
NP435_03905	COG1653	transport
NP435_03910	COG4209	transmembrane transport
NP435_03915	COG0395	ABC-type sugar transport system, permease component
NP435_03920	COG1486	melibiose metabolic process
NP435_03925	COG2323	membrane
NP435_03930	COG2329	Antibiotic biosynthesis monooxygenase
NP435_03935	COG0346	lactoylglutathione lyase activity
NP435_03950	COG5583	Uncharacterized small protein (DUF2292)
NP435_03955	COG0670	Belongs to the BI1 family
NP435_03960	COG0697	spore germination
NP435_03965	COG1846	Transcriptional regulator
NP435_03970	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NP435_03980	COG2124	cytochrome p450
NP435_03980	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NP435_03985	COG1368	sulfuric ester hydrolase activity
NP435_03990	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
NP435_03995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NP435_04000	COG1442	glycosyl transferase family 8
NP435_04005	COG1216	Glycosyl transferase, family 2
NP435_04010	COG1442	glycosyl transferase family 8
NP435_04015	COG2223	nitrite transmembrane transporter activity
NP435_04020	COG1011	Hydrolase
NP435_04025	COG0531	amino acid
NP435_04030	COG1012	belongs to the aldehyde dehydrogenase family
NP435_04035	COG0840	transmembrane signaling receptor activity
NP435_04040	COG0488	(ABC) transporter
NP435_04050	COG0789	Transcriptional regulator
NP435_04055	COG2814	Major facilitator Superfamily
NP435_04065	COG0488	(ABC) transporter
NP435_04070	COG0513	Belongs to the DEAD box helicase family
NP435_04075	COG0456	acetyltransferase
NP435_04080	COG2130	NADP-dependent
NP435_04085	COG2211	Major facilitator Superfamily
NP435_04090	COG1262	PFAM Formylglycine-generating sulfatase enzyme
NP435_04095	COG1120	ATPase activity
NP435_04100	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP435_04105	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP435_04110	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NP435_04125	COG3866	Pectate lyase
NP435_04130	COG0471	metal ion transport
NP435_04135	COG3290	protein histidine kinase activity
NP435_04140	COG4565	transcriptional regulatory protein
NP435_04145	COG3181	Tripartite tricarboxylate transporter family receptor
NP435_04155	COG2851	Citrate transporter
NP435_04160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP435_04165	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
NP435_04170	COG1254	Belongs to the acylphosphatase family
NP435_04175	COG2258	MOSC domain
NP435_04195	COG0024	Methionine aminopeptidase
NP435_04200	COG1263	PTS System
NP435_04200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP435_04205	COG1368	sulfuric ester hydrolase activity
NP435_04220	COG1115	amino acid carrier protein
NP435_04225	COG0531	amino acid
NP435_04240	COG0697	spore germination
NP435_04245	COG1263	PTS System
NP435_04245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP435_04250	COG0366	Alpha amylase catalytic
NP435_04255	COG2188	Transcriptional regulator
NP435_04260	COG0778	Nitroreductase
NP435_04265	COG0737	Belongs to the 5'-nucleotidase family
NP435_04270	COG0693	protein deglycase activity
NP435_04275	COG2814	Major facilitator Superfamily
NP435_04280	COG4840	Belongs to the UPF0435 family
NP435_04285	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NP435_04290	COG4980	gas vesicle protein
NP435_04295	COG1295	ribonuclease BN
NP435_04300	COG0477	Major facilitator Superfamily
NP435_04305	COG0387	Pfam Sodium calcium exchanger
NP435_04315	COG0668	transmembrane transport
NP435_04320	COG0535	radical SAM domain protein
NP435_04330	COG0726	polysaccharide deacetylase
NP435_04335	COG2084	Dehydrogenase
NP435_04340	COG0598	Magnesium transport protein CorA
NP435_04345	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
NP435_04350	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
NP435_04360	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
NP435_04365	COG4637	Psort location Cytoplasmic, score
NP435_04380	COG0022	dehydrogenase e1 component
NP435_04385	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP435_04390	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NP435_04395	COG3284	Transcriptional regulator
NP435_04405	COG1742	UPF0060 membrane protein
NP435_04430	COG4842	Belongs to the WXG100 family
NP435_04435	COG1486	melibiose metabolic process
NP435_04440	COG1737	Transcriptional regulator
NP435_04445	COG1263	PTS System
NP435_04445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP435_04450	COG1132	(ABC) transporter
NP435_04455	COG1132	(ABC) transporter
NP435_04460	COG2259	Doxx family
NP435_04465	COG2514	catechol 2,3-dioxygenase activity
NP435_04470	COG1917	Cupin 2, conserved barrel domain protein
NP435_04470	COG4977	sequence-specific DNA binding
NP435_04475	COG2814	Major facilitator Superfamily
NP435_04480	COG1082	Xylose isomerase domain protein TIM barrel
NP435_04485	COG0673	inositol 2-dehydrogenase activity
NP435_04490	COG4585	Histidine kinase
NP435_04495	COG2197	response regulator
NP435_04500	COG1131	(ABC) transporter
NP435_04505	COG0842	Transport permease protein
NP435_04505	COG1511	domain protein
NP435_04510	COG0842	Transport permease protein
NP435_04515	COG1695	Transcriptional regulator
NP435_04520	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
NP435_04525	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
NP435_04530	COG1309	transcriptional regulator
NP435_04535	COG2814	Major facilitator Superfamily
NP435_04540	COG2318	DinB family
NP435_04545	COG2814	Major facilitator Superfamily
NP435_04550	COG1846	Transcriptional regulator
NP435_04555	COG0392	lysyltransferase activity
NP435_04555	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
NP435_04560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP435_04565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP435_04570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP435_04575	COG0384	phenazine biosynthesis protein PhzF
NP435_04580	COG0778	Nitroreductase
NP435_04595	COG1090	epimerase
NP435_04600	COG2137	regulation of response to DNA damage stimulus
NP435_04610	COG2814	Major facilitator Superfamily
NP435_04625	COG3103	Sh3 type 3 domain protein
NP435_04630	COG5658	integral membrane protein
NP435_04635	COG0596	Alpha beta hydrolase
NP435_04640	COG0463	Glycosyl transferase, family 2
NP435_04645	COG4485	Bacterial membrane protein, YfhO
NP435_04650	COG1988	membrane-bound metal-dependent
NP435_04655	COG1194	a g-specific adenine glycosylase
NP435_04665	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_04680	COG3557	Belongs to the UPF0374 family
NP435_04685	COG1132	(ABC) transporter
NP435_04690	COG4129	membrane
NP435_04695	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NP435_04700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
NP435_04705	COG0735	belongs to the Fur family
NP435_04815	COG4326	sporulation control protein
NP435_04825	COG5577	PFAM Coat F domain
NP435_04830	COG3340	Belongs to the peptidase S51 family
NP435_04835	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
NP435_04840	COG0277	FAD linked oxidase domain protein
NP435_04850	COG0753	catalase activity
NP435_04855	COG1116	anion transmembrane transporter activity
NP435_04860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NP435_04865	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NP435_04870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP435_04880	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
NP435_04890	COG1476	TRANSCRIPTIONal
NP435_04900	COG3382	B3 4 domain protein
NP435_04905	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
NP435_04915	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
NP435_04920	COG0789	Transcriptional regulator
NP435_04925	COG1664	Polymer-forming cytoskeletal
NP435_04930	COG1664	Polymer-forming cytoskeletal
NP435_04935	COG2766	serine protein kinase
NP435_04940	COG2718	Belongs to the UPF0229 family
NP435_04945	COG1846	Transcriptional regulator
NP435_04950	COG1566	PFAM secretion protein HlyD family protein
NP435_04955	COG2814	Major facilitator Superfamily
NP435_04960	COG0655	NAD(P)H dehydrogenase (quinone) activity
NP435_04980	COG1725	Transcriptional regulator
NP435_04985	COG1131	(ABC) transporter
NP435_04990	COG1131	(ABC) transporter
NP435_04995	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NP435_05000	COG1278	Cold shock
NP435_05005	COG1464	Belongs to the NlpA lipoprotein family
NP435_05010	COG3706	GGDEF domain
NP435_05015	COG1823	symporter activity
NP435_05035	COG5577	PFAM Coat F domain
NP435_05040	COG4085	toxin activity
NP435_05040	COG1525	nuclease
NP435_05040	COG0737	Belongs to the 5'-nucleotidase family
NP435_05045	COG3764	Sortase (surface protein transpeptidase)
NP435_05050	COG0564	pseudouridine synthase activity
NP435_05060	COG0517	IMP dehydrogenase activity
NP435_05065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NP435_05070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NP435_05070	COG3153	acetyltransferase
NP435_05075	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NP435_05080	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
NP435_05085	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
NP435_05090	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
NP435_05095	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
NP435_05100	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
NP435_05105	COG2203	Gaf domain
NP435_05105	COG4585	Histidine kinase
NP435_05110	COG2197	response regulator
NP435_05115	COG0431	NADPH-dependent FMN reductase
NP435_05130	COG0791	NLP P60 protein
NP435_05130	COG1388	LysM domain
NP435_05135	COG1959	2 iron, 2 sulfur cluster binding
NP435_05140	COG0668	transmembrane transport
NP435_05145	COG2719	SpoVR family
NP435_05150	COG1785	Belongs to the alkaline phosphatase family
NP435_05155	COG0791	NLP P60 protein
NP435_05155	COG1388	LysM domain
NP435_05160	COG0583	DNA-binding transcription factor activity
NP435_05165	COG0372	Belongs to the citrate synthase family
NP435_05170	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_05175	COG0531	amino acid
NP435_05180	COG0733	neurotransmitter:sodium symporter activity
NP435_05185	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP435_05190	COG0456	acetyltransferase
NP435_05205	COG1595	DNA-templated transcription, initiation
NP435_05210	COG0667	Aldo Keto reductase
NP435_05215	COG0204	Acyl-transferase
NP435_05220	COG1253	flavin adenine dinucleotide binding
NP435_05225	COG0789	Transcriptional regulator
NP435_05230	COG0436	Aminotransferase
NP435_05235	COG1253	flavin adenine dinucleotide binding
NP435_05240	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NP435_05245	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
NP435_05250	COG0584	glycerophosphoryl diester phosphodiesterase
NP435_05260	COG0668	transmembrane transport
NP435_05265	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
NP435_05270	COG0726	polysaccharide deacetylase
NP435_05275	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP435_05280	COG1757	Na H antiporter
NP435_05285	COG0589	response to stress
NP435_05295	COG1132	(ABC) transporter
NP435_05300	COG1132	(ABC) transporter
NP435_05305	COG0702	epimerase
NP435_05325	COG0189	ligase activity
NP435_05330	COG0189	ligase activity
NP435_05335	COG4399	Belongs to the UPF0754 family
NP435_05340	COG3679	Belongs to the UPF0342 family
NP435_05345	COG4335	DNA alkylation repair
NP435_05350	COG0561	phosphatase activity
NP435_05355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NP435_05360	COG0475	glutathione-regulated potassium exporter activity
NP435_05365	COG0490	domain, Protein
NP435_05375	COG1024	Enoyl-CoA hydratase
NP435_05385	COG4152	abc transporter atp-binding protein
NP435_05390	COG1668	transmembrane transport
NP435_05395	COG0420	3'-5' exonuclease activity
NP435_05400	COG4717	serine-type aminopeptidase activity
NP435_05405	COG3481	metal-dependent phosphohydrolase, HD sub domain
NP435_05415	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
NP435_05445	COG1846	Transcriptional regulator
NP435_05450	COG4980	gas vesicle protein
NP435_05465	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
NP435_05470	COG0537	adenosine 5'-monophosphoramidase activity
NP435_05475	COG1131	(ABC) transporter
NP435_05480	COG4473	ABC transporter
NP435_05490	COG1473	amidohydrolase
NP435_05495	COG3069	C4-dicarboxylate transmembrane transporter activity
NP435_05505	COG2329	Antibiotic biosynthesis monooxygenase
NP435_05510	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP435_05515	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
NP435_05520	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
NP435_05525	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
NP435_05530	COG1309	transcriptional regulator
NP435_05535	COG1511	domain protein
NP435_05540	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NP435_05545	COG4377	Putative membrane peptidase family (DUF2324)
NP435_05555	COG1363	Peptidase, m42
NP435_05560	COG4405	Protein conserved in bacteria
NP435_05565	COG1301	dicarboxylic acid transport
NP435_05575	COG1234	tRNA 3'-trailer cleavage
NP435_05580	COG0095	Lipoate-protein ligase
NP435_05585	COG0702	epimerase
NP435_05590	COG0318	PFAM AMP-dependent synthetase and ligase
NP435_05600	COG0501	Belongs to the peptidase M48B family
NP435_05605	COG1404	Belongs to the peptidase S8 family
NP435_05610	COG0456	acetyltransferase
NP435_05615	COG0604	alcohol dehydrogenase
NP435_05620	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
NP435_05625	COG0406	alpha-ribazole phosphatase activity
NP435_05630	COG0183	Belongs to the thiolase family
NP435_05635	COG0318	PFAM AMP-dependent synthetase and ligase
NP435_05640	COG1268	BioY protein
NP435_05645	COG0840	transmembrane signaling receptor activity
NP435_05650	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NP435_05650	COG0723	plastoquinol--plastocyanin reductase activity
NP435_05655	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_05665	COG4903	ComK protein
NP435_05670	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_05680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP435_05695	COG0398	Pfam SNARE associated Golgi protein
NP435_05700	COG0681	Belongs to the peptidase S26 family
NP435_05705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
NP435_05710	COG1846	Transcriptional regulator
NP435_05715	COG0738	Major facilitator superfamily
NP435_05720	COG0673	inositol 2-dehydrogenase activity
NP435_05725	COG0561	phosphatase activity
NP435_05730	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NP435_05735	COG1609	Transcriptional regulator
NP435_05740	COG3180	Ammonia monooxygenase
NP435_05745	COG2814	Major facilitator Superfamily
NP435_05745	COG0477	Major facilitator Superfamily
NP435_05750	COG4533	DNA binding
NP435_05760	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
NP435_05765	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
NP435_05770	COG1074	ATP-dependent DNA helicase activity
NP435_05775	COG0420	3'-5' exonuclease activity
NP435_05780	COG0419	ATPase involved in DNA repair
NP435_05785	COG1403	HNH endonuclease
NP435_05825	COG5337	Spore coat protein CotH
NP435_05830	COG0179	Fumarylacetoacetate (FAA) hydrolase
NP435_05840	COG1404	Belongs to the peptidase S8 family
NP435_05850	COG0367	asparagine synthase
NP435_05855	COG2318	DinB family
NP435_05860	COG1562	ergosterol biosynthetic process
NP435_05865	COG0534	Mate efflux family protein
NP435_05870	COG1917	Cupin 2, conserved barrel domain protein
NP435_05870	COG2207	Transcriptional regulator
NP435_05875	COG1609	Transcriptional regulator
NP435_05880	COG0673	inositol 2-dehydrogenase activity
NP435_05885	COG2318	DinB family
NP435_05890	COG1279	arginine transmembrane transporter activity
NP435_05895	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
NP435_05900	COG1357	PFAM Pentapeptide repeats (8 copies)
NP435_05905	COG2267	carboxylic ester hydrolase activity
NP435_05910	COG0529	Catalyzes the synthesis of activated sulfate
NP435_05915	COG2046	Belongs to the sulfate adenylyltransferase family
NP435_05920	COG0175	sulfate reduction
NP435_05925	COG2045	Belongs to the ComB family
NP435_05930	COG1809	phosphosulfolactate synthase activity
NP435_05935	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP435_05940	COG4948	Mandelate Racemase Muconate Lactonizing
NP435_05945	COG2814	Major facilitator Superfamily
NP435_05950	COG0454	-acetyltransferase
NP435_05955	COG2153	protein acetylation
NP435_05960	COG0646	methionine synthase
NP435_05960	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
NP435_05965	COG1666	GTP binding
NP435_05970	COG2996	Protein conserved in bacteria
NP435_05990	COG1695	Transcriptional regulator
NP435_06005	COG3227	Zinc metalloprotease (Elastase)
NP435_06010	COG1307	EDD domain protein, DegV family
NP435_06015	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP435_06035	COG0561	phosphatase activity
NP435_06040	COG1073	alpha beta
NP435_06045	COG2151	metal-sulfur cluster biosynthetic enzyme
NP435_06055	COG0277	FAD linked oxidase domain protein
NP435_06060	COG2271	Major facilitator Superfamily
NP435_06065	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
NP435_06070	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
NP435_06080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NP435_06085	COG0505	Belongs to the CarA family
NP435_06090	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NP435_06095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
NP435_06110	COG2267	carboxylic ester hydrolase activity
NP435_06120	COG1744	ABC transporter substrate-binding protein PnrA-like
NP435_06135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NP435_06140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NP435_06145	COG5504	Zn-dependent protease
NP435_06150	COG0444	Belongs to the ABC transporter superfamily
NP435_06155	COG4608	Belongs to the ABC transporter superfamily
NP435_06165	COG0601	transmembrane transport
NP435_06170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP435_06180	COG0180	Tryptophanyl-tRNA synthetase
NP435_06185	COG4166	transmembrane transport
NP435_06190	COG0601	transmembrane transport
NP435_06195	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP435_06200	COG0444	Belongs to the ABC transporter superfamily
NP435_06205	COG4608	Belongs to the ABC transporter superfamily
NP435_06210	COG2814	Major facilitator Superfamily
NP435_06215	COG0456	acetyltransferase
NP435_06220	COG1393	Belongs to the ArsC family
NP435_06225	COG0861	Integral membrane protein TerC family
NP435_06235	COG4862	establishment of competence for transformation
NP435_06245	COG4469	Competence protein
NP435_06250	COG1164	Oligoendopeptidase f
NP435_06260	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NP435_06265	COG2346	COG2346, Truncated hemoglobins
NP435_06270	COG0741	lytic transglycosylase activity
NP435_06275	COG4116	CYTH
NP435_06285	COG2357	RelA SpoT domain protein
NP435_06290	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NP435_06295	COG0564	pseudouridine synthase activity
NP435_06300	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
NP435_06305	COG0475	glutathione-regulated potassium exporter activity
NP435_06305	COG0569	domain protein
NP435_06310	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
NP435_06315	COG0352	thiamine-phosphate diphosphorylase activity
NP435_06320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NP435_06325	COG2104	thiamine diphosphate biosynthetic process
NP435_06330	COG2022	thiamine diphosphate biosynthetic process
NP435_06335	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NP435_06340	COG0351	phosphomethylpyrimidine kinase
NP435_06345	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
NP435_06400	COG0210	DNA helicase
NP435_06410	COG2153	protein acetylation
NP435_06415	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NP435_06420	COG2382	esterase
NP435_06425	COG0626	cystathionine gamma-synthase activity
NP435_06430	COG0626	cystathionine gamma-synthase activity
NP435_06435	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP435_06440	COG5505	Protein of unknown function (DUF819)
NP435_06470	COG3677	Transposase
NP435_06485	COG5484	DNA packaging
NP435_06490	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
NP435_06495	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_06505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP435_06505	COG3711	transcriptional antiterminator
NP435_06510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP435_06510	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP435_06510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP435_06515	COG1482	cell wall glycoprotein biosynthetic process
NP435_06525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP435_06535	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NP435_06550	COG0109	protoheme IX farnesyltransferase activity
NP435_06560	COG0726	polysaccharide deacetylase
NP435_06575	COG5504	Zn-dependent protease
NP435_06580	COG2205	protein histidine kinase activity
NP435_06590	COG3383	formate dehydrogenase (NAD+) activity
NP435_06595	COG2427	Protein of unknown function (DUF1641)
NP435_06605	COG1051	belongs to the nudix hydrolase family
NP435_06615	COG2124	cytochrome p450
NP435_06620	COG1819	glycosyl
NP435_06630	COG1587	Uroporphyrinogen-III synthase
NP435_06635	COG0390	transport system, permease component
NP435_06640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NP435_06645	COG0697	spore germination
NP435_06650	COG4297	protein containing double-stranded beta helix domain
NP435_06660	COG1252	NADH dehydrogenase
NP435_06665	COG1904	glucuronate isomerase
NP435_06670	COG2211	Major facilitator Superfamily
NP435_06675	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
NP435_06680	COG1063	alcohol dehydrogenase
NP435_06685	COG1312	Catalyzes the dehydration of D-mannonate
NP435_06690	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_06695	COG2271	Major facilitator Superfamily
NP435_06700	COG1609	Transcriptional regulator
NP435_06705	COG0246	Mannitol dehydrogenase
NP435_06710	COG2721	sulfolactate sulfo-lyase activity
NP435_06715	COG0730	response to heat
NP435_06720	COG2318	DinB family
NP435_06725	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
NP435_06730	COG0457	Tetratricopeptide repeat
NP435_06740	COG2350	Protein conserved in bacteria
NP435_06745	COG5632	N-Acetylmuramoyl-L-alanine amidase
NP435_06745	COG3409	Peptidoglycan-binding domain 1 protein
NP435_06745	COG1388	LysM domain
NP435_06755	COG4195	phage-related replication protein
NP435_06760	COG3546	catalase activity
NP435_06765	COG2856	Zn peptidase
NP435_06770	COG1396	sequence-specific DNA binding
NP435_06780	COG1522	sequence-specific DNA binding
NP435_06785	COG1484	DNA-dependent DNA replication
NP435_06805	COG1595	DNA-templated transcription, initiation
NP435_06810	COG3728	DNA packaging
NP435_06810	COG5484	DNA packaging
NP435_06815	COG1783	phage Terminase large subunit
NP435_06820	COG5518	Phage portal protein
NP435_06825	COG0338	D12 class N6 adenine-specific DNA methyltransferase
NP435_06830	COG4653	Phage capsid family
NP435_06880	COG3953	SLT domain
NP435_06880	COG5412	phage tail tape measure protein
NP435_06885	COG1652	LysM domain
NP435_06890	COG4193	domain, Protein
NP435_06900	COG3628	GPW Gp25 family protein
NP435_06905	COG3299	homolog of phage Mu protein gp47
NP435_06910	COG3778	Protein conserved in bacteria
NP435_06950	COG3409	Peptidoglycan-binding domain 1 protein
NP435_06950	COG5632	N-Acetylmuramoyl-L-alanine amidase
NP435_06970	COG0306	phosphate transporter
NP435_06975	COG1392	Phosphate transport regulator
NP435_06980	COG0531	amino acid
NP435_06985	COG0346	lactoylglutathione lyase activity
NP435_06995	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NP435_07000	COG0463	Glycosyl transferase, family 2
NP435_07010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NP435_07015	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NP435_07020	COG2362	D-Aminopeptidase
NP435_07025	COG0601	transmembrane transport
NP435_07030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
NP435_07035	COG0444	Belongs to the ABC transporter superfamily
NP435_07040	COG4166	transmembrane transport
NP435_07045	COG1619	proteins homologs of microcin C7 resistance protein MccF
NP435_07050	COG4948	Mandelate Racemase Muconate Lactonizing
NP435_07055	COG0791	NLP P60 protein
NP435_07060	COG4608	Belongs to the ABC transporter superfamily
NP435_07065	COG2706	6-phosphogluconolactonase activity
NP435_07070	COG1834	amidinotransferase
NP435_07075	COG1607	acyl-coa hydrolase
NP435_07080	COG1017	nitric oxide dioxygenase activity
NP435_07080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
NP435_07090	COG2323	membrane
NP435_07095	COG2318	DinB family
NP435_07100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP435_07105	COG2076	Multidrug Resistance protein
NP435_07110	COG2076	Multidrug Resistance protein
NP435_07115	COG0788	formyltetrahydrofolate deformylase activity
NP435_07120	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NP435_07125	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
NP435_07130	COG1764	response to oxidative stress
NP435_07135	COG1846	Transcriptional regulator
NP435_07140	COG1764	response to oxidative stress
NP435_07150	COG0590	tRNA wobble adenosine to inosine editing
NP435_07155	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NP435_07160	COG1404	Belongs to the peptidase S8 family
NP435_07165	COG1366	Belongs to the anti-sigma-factor antagonist family
NP435_07170	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
NP435_07175	COG1122	ATPase activity
NP435_07180	COG4721	ABC-type cobalt transport system, permease component
NP435_07190	COG0745	RESPONSE REGULATOR receiver
NP435_07195	COG5002	protein histidine kinase activity
NP435_07195	COG3850	Histidine kinase
NP435_07200	COG3212	peptidase
NP435_07205	COG3212	peptidase
NP435_07220	COG2239	Acts as a magnesium transporter
NP435_07225	COG0789	Transcriptional regulator
NP435_07240	COG1846	Transcriptional regulator
NP435_07245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NP435_07250	COG0726	polysaccharide deacetylase
NP435_07255	COG1408	metallophosphoesterase
NP435_07265	COG0463	Glycosyl transferase, family 2
NP435_07270	COG1793	dna ligase
NP435_07270	COG3285	dna ligase
NP435_07275	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
NP435_07280	COG3300	MHYT domain
NP435_07280	COG5001	Diguanylate cyclase
NP435_07285	COG0586	Pfam SNARE associated Golgi protein
NP435_07290	COG0861	Integral membrane protein TerC family
NP435_07295	COG1191	sigma factor activity
NP435_07315	COG0501	Belongs to the peptidase M48B family
NP435_07320	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NP435_07335	COG3594	Acyltransferase
NP435_07340	COG5002	protein histidine kinase activity
NP435_07345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
NP435_07355	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
NP435_07360	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
NP435_07365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
NP435_07370	COG0436	Aminotransferase
NP435_07375	COG1850	ribulose-bisphosphate carboxylase activity
NP435_07380	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
NP435_07385	COG0235	Class ii aldolase
NP435_07390	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
NP435_07395	COG3339	Conserved Protein
NP435_07410	COG3852	Histidine kinase
NP435_07415	COG1846	Transcriptional regulator
NP435_07420	COG1360	Flagellar Motor Protein
NP435_07425	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NP435_07430	COG0542	response to heat
NP435_07435	COG3949	Membrane
NP435_07440	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
NP435_07445	COG0720	synthase
NP435_07450	COG0602	queuosine metabolic process
NP435_07455	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
NP435_07460	COG1733	regulation of RNA biosynthetic process
NP435_07465	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_07470	COG1388	LysM domain
NP435_07470	COG4641	Protein conserved in bacteria
NP435_07475	COG1388	LysM domain
NP435_07480	COG3858	chitin binding
NP435_07490	COG4873	Protein conserved in bacteria
NP435_07500	COG3773	Cell wall hydrolase
NP435_07505	COG2244	polysaccharide biosynthetic process
NP435_07510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP435_07515	COG2217	Heavy metal translocating P-type atpase
NP435_07525	COG0006	proline dipeptidase activity
NP435_07530	COG1609	Transcriptional regulator
NP435_07535	COG3711	transcriptional antiterminator
NP435_07540	COG1263	PTS System
NP435_07540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP435_07540	COG2190	(PTS) system
NP435_07545	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP435_07550	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
NP435_07560	COG1533	DNA photolyase activity
NP435_07565	COG0456	acetyltransferase
NP435_07570	COG0840	transmembrane signaling receptor activity
NP435_07575	COG2084	Dehydrogenase
NP435_07580	COG2340	Cysteine-rich secretory protein family
NP435_07585	COG0768	penicillin binding
NP435_07590	COG4191	Histidine kinase
NP435_07595	COG0436	Aminotransferase
NP435_07605	COG0784	Response regulator, receiver
NP435_07605	COG0835	chemotaxis
NP435_07615	COG2814	Major facilitator Superfamily
NP435_07620	COG1376	ErfK ybiS ycfS ynhG family protein
NP435_07625	COG1408	metallophosphoesterase
NP435_07630	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_07635	COG3409	Peptidoglycan-binding domain 1 protein
NP435_07640	COG3409	Peptidoglycan-binding domain 1 protein
NP435_07650	COG2200	EAL domain
NP435_07655	COG4703	Protein of unknown function (DUF1797)
NP435_07660	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
NP435_07670	COG0517	IMP dehydrogenase activity
NP435_07675	COG0583	DNA-binding transcription factor activity
NP435_07680	COG0716	FMN binding
NP435_07690	COG0716	FMN binding
NP435_07695	COG2171	N-acyltransferase activity
NP435_07700	COG1473	amidohydrolase
NP435_07710	COG0668	transmembrane transport
NP435_07715	COG0450	alkyl hydroperoxide reductase
NP435_07720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP435_07735	COG0746	molybdenum cofactor guanylyltransferase activity
NP435_07740	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
NP435_07745	COG0303	'Molybdopterin
NP435_07750	COG1763	Mo-molybdopterin cofactor biosynthetic process
NP435_07755	COG0314	molybdopterin synthase activity
NP435_07760	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
NP435_07765	COG1132	(ABC) transporter
NP435_07770	COG1132	(ABC) transporter
NP435_07780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NP435_07785	COG1136	(ABC) transporter
NP435_07790	COG0577	efflux transmembrane transporter activity
NP435_07795	COG1349	DNA-binding transcription factor activity
NP435_07800	COG1105	Belongs to the carbohydrate kinase PfkB family
NP435_07805	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP435_07805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP435_07805	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
NP435_07810	COG0681	Belongs to the peptidase S26 family
NP435_07820	COG0488	(ABC) transporter
NP435_07825	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NP435_07830	COG2309	aminopeptidase activity
NP435_07840	COG1077	Cell shape determining protein MreB Mrl
NP435_07845	COG2002	toxin-antitoxin pair type II binding
NP435_07850	COG3852	Histidine kinase
NP435_07855	COG2105	PFAM AIG2 family protein
NP435_07855	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
NP435_07860	COG0569	domain protein
NP435_07865	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
NP435_07870	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NP435_07875	COG5503	Protein of unknown function (DUF1447)
NP435_07880	COG0561	phosphatase activity
NP435_07885	COG0242	peptide deformylase activity
NP435_07895	COG0497	DNA recombination
NP435_07900	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NP435_07905	COG0022	dehydrogenase e1 component
NP435_07910	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP435_07915	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NP435_07930	COG1982	Orn Lys Arg decarboxylase major
NP435_07935	COG4476	Belongs to the UPF0223 family
NP435_07940	COG4493	Belongs to the UPF0637 family
NP435_07950	COG0483	inositol monophosphate 1-phosphatase activity
NP435_07960	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
NP435_07980	COG1595	DNA-templated transcription, initiation
NP435_08000	COG1217	gtp-binding protein TYPA
NP435_08010	COG4896	Protein conserved in bacteria
NP435_08020	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
NP435_08025	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NP435_08030	COG2066	Belongs to the glutaminase family
NP435_08035	COG4838	Belongs to the UPF0358 family
NP435_08040	COG0772	Belongs to the SEDS family
NP435_08045	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
NP435_08050	COG1612	heme a metabolic process
NP435_08055	COG0109	protoheme IX farnesyltransferase activity
NP435_08060	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NP435_08060	COG2010	Cytochrome c
NP435_08065	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NP435_08070	COG1845	cytochrome c oxidase, subunit III
NP435_08075	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NP435_08080	COG3336	cytochrome c oxidase
NP435_08090	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
NP435_08095	COG2340	Cysteine-rich secretory protein family
NP435_08110	COG3679	Belongs to the UPF0342 family
NP435_08115	COG4471	UPF0298 protein
NP435_08120	COG0742	ribosomal rna small subunit methyltransferase
NP435_08125	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
NP435_08130	COG3314	Sporulation integral membrane protein YlbJ
NP435_08135	COG1752	Esterase of the alpha-beta hydrolase superfamily
NP435_08140	COG3480	Lon protease (S16) C-terminal proteolytic domain
NP435_08145	COG1323	Belongs to the UPF0348 family
NP435_08155	COG1399	metal-binding, possibly nucleic acid-binding protein
NP435_08170	COG0454	-acetyltransferase
NP435_08175	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
NP435_08180	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
NP435_08185	COG2001	Belongs to the MraZ family
NP435_08190	COG0275	rRNA processing
NP435_08195	COG4839	cell division protein FtsL
NP435_08200	COG0768	penicillin binding
NP435_08205	COG0768	penicillin binding
NP435_08210	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
NP435_08215	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NP435_08220	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NP435_08225	COG0772	Belongs to the SEDS family
NP435_08230	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NP435_08235	COG0812	UDP-N-acetylmuramate dehydrogenase activity
NP435_08240	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
NP435_08245	COG3879	Bacterial protein of unknown function (DUF881)
NP435_08250	COG3879	Bacterial protein of unknown function (DUF881)
NP435_08255	COG3856	small basic protein
NP435_08260	COG0849	cell division
NP435_08265	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
NP435_08270	COG1404	Belongs to the peptidase S8 family
NP435_08270	COG4412	M6 family metalloprotease domain protein
NP435_08280	COG1191	sigma factor activity
NP435_08285	COG1191	sigma factor activity
NP435_08290	COG1119	ATPase activity
NP435_08295	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NP435_08300	COG1873	PFAM PRC-barrel domain
NP435_08305	COG1496	oxidoreductase activity
NP435_08310	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
NP435_08315	COG1799	cell septum assembly
NP435_08320	COG0762	integral membrane protein
NP435_08325	COG2302	S4 RNA-binding domain
NP435_08330	COG3599	regulation of cell shape
NP435_08335	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
NP435_08340	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NP435_08345	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
NP435_08350	COG0564	pseudouridine synthase activity
NP435_08355	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
NP435_08360	COG2233	PERMEase
NP435_08365	COG0540	Belongs to the ATCase OTCase family
NP435_08370	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NP435_08375	COG0505	Belongs to the CarA family
NP435_08380	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
NP435_08385	COG0543	2 iron, 2 sulfur cluster binding
NP435_08390	COG0167	dihydroorotate dehydrogenase activity
NP435_08395	COG0284	orotidine-5'-phosphate decarboxylase activity
NP435_08400	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
NP435_08405	COG0175	sulfate reduction
NP435_08410	COG0306	phosphate transporter
NP435_08415	COG2046	Belongs to the sulfate adenylyltransferase family
NP435_08420	COG0529	Catalyzes the synthesis of activated sulfate
NP435_08425	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
NP435_08430	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
NP435_08435	COG1648	precorrin-2 dehydrogenase activity
NP435_08440	COG1293	RNA-binding protein homologous to eukaryotic snRNP
NP435_08445	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NP435_08450	COG1561	YicC-like family, N-terminal region
NP435_08460	COG0194	GDP metabolic process
NP435_08465	COG1758	RNA polymerase activity
NP435_08470	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NP435_08475	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
NP435_08480	COG0242	peptide deformylase activity
NP435_08485	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
NP435_08490	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NP435_08490	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
NP435_08495	COG0820	rRNA (adenine-C2-)-methyltransferase activity
NP435_08500	COG0631	protein serine/threonine phosphatase activity
NP435_08505	COG0515	serine threonine protein kinase
NP435_08505	COG2815	serine threonine protein kinase
NP435_08510	COG1162	GTPase activity
NP435_08515	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
NP435_08520	COG1564	THIamine pyrophosphokinase
NP435_08530	COG0227	Belongs to the bacterial ribosomal protein bL28 family
NP435_08535	COG1302	Protein conserved in bacteria
NP435_08540	COG1461	Dihydroxyacetone kinase
NP435_08545	COG1760	l-serine dehydratase
NP435_08550	COG1760	l-serine dehydratase
NP435_08555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
NP435_08560	COG1349	DNA-binding transcription factor activity
NP435_08560	COG2050	protein possibly involved in aromatic compounds catabolism
NP435_08565	COG0416	fatty acid biosynthetic process
NP435_08570	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NP435_08575	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_08585	COG0571	ribonuclease III activity
NP435_08590	COG1196	nuclear chromosome segregation
NP435_08595	COG0552	protein localization to endoplasmic reticulum
NP435_08605	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
NP435_08610	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
NP435_08615	COG0228	four-way junction DNA binding
NP435_08620	COG1837	Belongs to the UPF0109 family
NP435_08630	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
NP435_08635	COG0336	Belongs to the RNA methyltransferase TrmD family
NP435_08640	COG0335	large ribosomal subunit rRNA binding
NP435_08645	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NP435_08650	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NP435_08660	COG2257	FlhB HrpN YscU SpaS Family
NP435_08665	COG0045	succinate-CoA ligase (ADP-forming) activity
NP435_08670	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
NP435_08675	COG0758	DNA mediated transformation
NP435_08680	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
NP435_08685	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
NP435_08690	COG4974	Belongs to the 'phage' integrase family
NP435_08695	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
NP435_08700	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
NP435_08705	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NP435_08710	COG1815	bacterial-type flagellum-dependent cell motility
NP435_08715	COG1558	bacterial-type flagellum-dependent cell motility
NP435_08720	COG1677	Flagellar hook-basal body complex protein FliE
NP435_08725	COG1766	The M ring may be actively involved in energy transduction
NP435_08730	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NP435_08735	COG1317	bacterial-type flagellum organization
NP435_08740	COG1157	protein secretion by the type III secretion system
NP435_08745	COG2882	bacterial-type flagellum organization
NP435_08750	COG3334	PFAM MgtE intracellular
NP435_08755	COG3144	bacterial-type flagellum assembly
NP435_08760	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
NP435_08765	COG4786	Flagellar basal body rod
NP435_08770	COG1582	Flagellar protein (FlbD)
NP435_08775	COG1580	Controls the rotational direction of flagella during chemotaxis
NP435_08780	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NP435_08785	COG1776	CheC inhibitor of MCP methylation
NP435_08785	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
NP435_08790	COG2201	protein-glutamate methylesterase activity
NP435_08795	COG3190	flagellar
NP435_08800	COG1338	Plays a role in the flagellum-specific transport system
NP435_08805	COG1987	bacterial-type flagellum assembly
NP435_08810	COG1684	flagellar biosynthetic protein fliR
NP435_08815	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NP435_08820	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
NP435_08825	COG1419	protein localization to endoplasmic reticulum
NP435_08830	COG0455	bacterial-type flagellum organization
NP435_08835	COG2201	protein-glutamate methylesterase activity
NP435_08840	COG0643	Histidine kinase
NP435_08840	COG2198	Histidine kinase
NP435_08845	COG0835	chemotaxis
NP435_08850	COG1776	CheC inhibitor of MCP methylation
NP435_08855	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
NP435_08860	COG1191	sigma factor activity
NP435_08870	COG0052	Belongs to the universal ribosomal protein uS2 family
NP435_08875	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
NP435_08880	COG0528	UMP kinase activity
NP435_08885	COG0233	cytoplasmic translational termination
NP435_08890	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
NP435_08895	COG4589	Belongs to the CDS family
NP435_08900	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
NP435_08905	COG0750	zinc metalloprotease
NP435_08910	COG0442	prolyl-tRNA aminoacylation
NP435_08915	COG2176	DNA-directed DNA polymerase activity
NP435_08920	COG0779	Required for maturation of 30S ribosomal subunits
NP435_08925	COG0195	Participates in both transcription termination and antitermination
NP435_08930	COG2740	Nucleic-acid-binding protein implicated in transcription termination
NP435_08935	COG1358	cellular component organization or biogenesis
NP435_08940	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
NP435_08945	COG1550	Protein conserved in bacteria
NP435_08950	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
NP435_08955	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
NP435_08960	COG0196	riboflavin kinase activity
NP435_08965	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
NP435_08970	COG1185	polyribonucleotide nucleotidyltransferase activity
NP435_08980	COG0612	Peptidase, M16
NP435_08985	COG1873	PFAM PRC-barrel domain
NP435_08990	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NP435_08995	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
NP435_09000	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
NP435_09005	COG0527	aspartate kinase activity
NP435_09010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
NP435_09015	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
NP435_09020	COG0740	serine-type endopeptidase activity
NP435_09030	COG4980	gas vesicle protein
NP435_09030	COG1674	ftsk spoiiie
NP435_09035	COG2188	Transcriptional regulator
NP435_09040	COG2814	Major facilitator Superfamily
NP435_09045	COG0612	Peptidase, M16
NP435_09050	COG0612	Peptidase, M16
NP435_09055	COG0300	oxidoreductase activity
NP435_09070	COG1426	Protein conserved in bacteria
NP435_09075	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
NP435_09080	COG1058	Belongs to the CinA family
NP435_09080	COG1546	Belongs to the CinA family
NP435_09085	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
NP435_09090	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NP435_09095	COG1418	mRNA catabolic process
NP435_09100	COG1692	metallophosphoesterase
NP435_09105	COG2359	stage V sporulation protein S
NP435_09110	COG1063	alcohol dehydrogenase
NP435_09115	COG0156	8-amino-7-oxononanoate synthase activity
NP435_09120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NP435_09125	COG4550	Control of competence regulator ComK, YlbF/YmcA
NP435_09135	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
NP435_09140	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
NP435_09155	COG3226	Transcriptional regulator
NP435_09160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP435_09170	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NP435_09175	COG3321	synthase
NP435_09180	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
NP435_09180	COG2070	2-Nitropropane dioxygenase
NP435_09185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NP435_09190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
NP435_09195	COG3425	synthase
NP435_09200	COG1024	Enoyl-CoA hydratase
NP435_09205	COG1024	Enoyl-CoA hydratase
NP435_09210	COG0300	oxidoreductase activity
NP435_09210	COG0318	PFAM AMP-dependent synthetase and ligase
NP435_09210	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP435_09210	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_09210	COG3321	synthase
NP435_09215	COG3321	synthase
NP435_09215	COG4221	oxidoreductase activity
NP435_09215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NP435_09215	COG0300	oxidoreductase activity
NP435_09220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NP435_09220	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NP435_09220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP435_09220	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_09220	COG3321	synthase
NP435_09230	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NP435_09230	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
NP435_09230	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
NP435_09230	COG3321	synthase
NP435_09235	COG2124	cytochrome p450
NP435_09245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP435_09250	COG1404	Belongs to the peptidase S8 family
NP435_09255	COG4195	phage-related replication protein
NP435_09260	COG1764	response to oxidative stress
NP435_09265	COG2076	Multidrug Resistance protein
NP435_09270	COG2076	Multidrug Resistance protein
NP435_09285	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
NP435_09290	COG1923	regulation of RNA biosynthetic process
NP435_09305	COG1780	Probably involved in ribonucleotide reductase function
NP435_09310	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NP435_09315	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
NP435_09320	COG4112	unkown
NP435_09325	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP435_09330	COG0464	growth
NP435_09335	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
NP435_09340	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
NP435_09345	COG0789	Transcriptional regulator
NP435_09350	COG0174	glutamine synthetase
NP435_09370	COG4282	regulation of fungal-type cell wall biogenesis
NP435_09380	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP435_09410	COG0135	phosphoribosylanthranilate isomerase activity
NP435_09415	COG2211	Major facilitator Superfamily
NP435_09420	COG3507	Belongs to the glycosyl hydrolase 43 family
NP435_09425	COG1940	carbohydrate kinase activity
NP435_09430	COG2115	Belongs to the xylose isomerase family
NP435_09435	COG1070	Carbohydrate kinase
NP435_09445	COG1525	nuclease
NP435_09455	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
NP435_09465	COG0756	dUTP diphosphatase activity
NP435_09505	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
NP435_09520	COG3832	glyoxalase III activity
NP435_09530	COG0697	spore germination
NP435_09535	COG0531	amino acid
NP435_09565	COG4195	phage-related replication protein
NP435_09575	COG0346	lactoylglutathione lyase activity
NP435_09585	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
NP435_09590	COG1388	LysM domain
NP435_09595	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NP435_09600	COG4224	UPF0291 protein
NP435_09605	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
NP435_09615	COG3763	UPF0154 protein
NP435_09625	COG0785	Cytochrome C biogenesis protein
NP435_09630	COG2201	protein-glutamate methylesterase activity
NP435_09635	COG4846	Membrane protein involved in cytochrome C biogenesis
NP435_09645	COG0071	Belongs to the small heat shock protein (HSP20) family
NP435_09660	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
NP435_09665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP435_09685	COG0824	Thioesterase
NP435_09695	COG4841	protein insertion into membrane
NP435_09700	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
NP435_09705	COG1832	CoA-binding protein
NP435_09710	COG0187	DNA topoisomerase II activity
NP435_09715	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
NP435_09725	COG1115	amino acid carrier protein
NP435_09730	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
NP435_09740	COG5520	Belongs to the glycosyl hydrolase 30 family
NP435_09745	COG3507	Belongs to the glycosyl hydrolase 43 family
NP435_09750	COG2246	polysaccharide biosynthetic process
NP435_09755	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NP435_09760	COG0586	Pfam SNARE associated Golgi protein
NP435_09765	COG2404	hydrolase activity, acting on ester bonds
NP435_09770	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NP435_09775	COG1024	Enoyl-CoA hydratase
NP435_09780	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NP435_09785	COG0511	ligase activity, forming carbon-carbon bonds
NP435_09790	COG0439	Biotin carboxylase
NP435_09795	COG0318	PFAM AMP-dependent synthetase and ligase
NP435_09800	COG1960	acyl-CoA dehydrogenase activity
NP435_09815	COG1649	PFAM Uncharacterised BCR, COG1649
NP435_09825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP435_09825	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
NP435_09830	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP435_09835	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP435_09840	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP435_09845	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP435_09850	COG2027	D-alanyl-D-alanine carboxypeptidase
NP435_09855	COG2017	converts alpha-aldose to the beta-anomer
NP435_09860	COG0534	Mate efflux family protein
NP435_09875	COG0582	viral genome integration into host DNA
NP435_09880	COG0166	Belongs to the GPI family
NP435_09885	COG0405	Gamma-glutamyltransferase
NP435_09890	COG0583	DNA-binding transcription factor activity
NP435_09895	COG0604	alcohol dehydrogenase
NP435_09900	COG0493	'glutamate synthase
NP435_09905	COG0067	glutamate synthase
NP435_09905	COG0069	glutamate synthase activity
NP435_09905	COG0070	glutamate synthase
NP435_09910	COG0583	DNA-binding transcription factor activity
NP435_09915	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
NP435_09920	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NP435_09930	COG0300	oxidoreductase activity
NP435_09935	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
NP435_09945	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP435_09950	COG2814	Major facilitator Superfamily
NP435_09965	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NP435_09970	COG0243	molybdopterin cofactor binding
NP435_10000	COG0840	transmembrane signaling receptor activity
NP435_10000	COG5278	phosphoserine phosphatase activity
NP435_10005	COG2368	4-hydroxyphenylacetate
NP435_10010	COG4305	rare lipoprotein A
NP435_10015	COG3619	membrane
NP435_10020	COG3866	Pectate lyase
NP435_10025	COG2135	peptidase activity
NP435_10035	COG2140	Oxalate decarboxylase
NP435_10050	COG0456	acetyltransferase
NP435_10070	COG2720	vancomycin resistance protein
NP435_10080	COG3655	Transcriptional regulator
NP435_10085	COG3739	integral membrane protein
NP435_10090	COG0583	DNA-binding transcription factor activity
NP435_10095	COG0697	spore germination
NP435_10105	COG0693	protein deglycase activity
NP435_10110	COG2367	Beta-lactamase
NP435_10125	COG0574	Belongs to the PEP-utilizing enzyme family
NP435_10125	COG3848	Pyruvate phosphate dikinase
NP435_10130	COG0726	polysaccharide deacetylase
NP435_10135	COG2314	TM2 domain
NP435_10140	COG1396	sequence-specific DNA binding
NP435_10160	COG2135	peptidase activity
NP435_10200	COG0457	Tetratricopeptide repeat
NP435_10225	COG5290	Psort location Cytoplasmic, score
NP435_10250	COG5444	nuclease activity
NP435_10255	COG4282	regulation of fungal-type cell wall biogenesis
NP435_10260	COG1231	oxidoreductase activity
NP435_10265	COG5434	Belongs to the glycosyl hydrolase 28 family
NP435_10270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP435_10275	COG0662	Cupin 2, conserved barrel domain protein
NP435_10275	COG2207	Transcriptional regulator
NP435_10280	COG0456	acetyltransferase
NP435_10285	COG1309	transcriptional regulator
NP435_10290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP435_10295	COG3708	Transcriptional regulator
NP435_10300	COG2378	regulation of single-species biofilm formation
NP435_10310	COG0640	Transcriptional regulator
NP435_10315	COG0741	lytic transglycosylase activity
NP435_10320	COG2322	membrane
NP435_10335	COG1619	proteins homologs of microcin C7 resistance protein MccF
NP435_10340	COG3239	Fatty acid desaturase
NP435_10345	COG4585	Histidine kinase
NP435_10350	COG2197	response regulator
NP435_10355	COG1388	LysM domain
NP435_10355	COG3584	3D domain protein
NP435_10360	COG0514	ATP-dependent DNA helicase (RecQ)
NP435_10370	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NP435_10375	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NP435_10390	COG0071	Belongs to the small heat shock protein (HSP20) family
NP435_10415	COG1012	belongs to the aldehyde dehydrogenase family
NP435_10420	COG1657	PFAM Prenyltransferase squalene oxidase
NP435_10425	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NP435_10430	COG0733	neurotransmitter:sodium symporter activity
NP435_10435	COG0385	Bile acid
NP435_10445	COG0567	Dehydrogenase, E1 component
NP435_10450	COG4548	von Willebrand factor, type A
NP435_10455	COG0714	Associated with various cellular activities
NP435_10460	COG2032	superoxide dismutase activity
NP435_10465	COG0791	NLP P60 protein
NP435_10465	COG1388	LysM domain
NP435_10470	COG1819	glycosyl
NP435_10475	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
NP435_10480	COG0534	Mate efflux family protein
NP435_10485	COG1366	Belongs to the anti-sigma-factor antagonist family
NP435_10490	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NP435_10495	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NP435_10505	COG2962	Rard protein
NP435_10520	COG2610	gluconate transmembrane transporter activity
NP435_10525	COG1942	4-Oxalocrotonate Tautomerase
NP435_10530	COG1733	regulation of RNA biosynthetic process
NP435_10535	COG0778	Nitroreductase
NP435_10540	COG0400	carboxylic ester hydrolase activity
NP435_10545	COG0346	lactoylglutathione lyase activity
NP435_10555	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP435_10560	COG0793	Belongs to the peptidase S41A family
NP435_10560	COG3409	Peptidoglycan-binding domain 1 protein
NP435_10565	COG2226	methyltransferase
NP435_10575	COG1876	peptidase activity
NP435_10580	COG0813	purine-nucleoside phosphorylase activity
NP435_10595	COG0671	phosphoesterase, PA-phosphatase related
NP435_10615	COG4479	Belongs to the UPF0346 family
NP435_10625	COG1509	lysine 2,3-aminomutase activity
NP435_10630	COG0456	acetyltransferase
NP435_10635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NP435_10640	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NP435_10645	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NP435_10650	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NP435_10665	COG0456	acetyltransferase
NP435_10670	COG0463	Glycosyl transferase, family 2
NP435_10685	COG4641	Protein conserved in bacteria
NP435_10690	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
NP435_10695	COG1086	Polysaccharide biosynthesis protein
NP435_10705	COG3331	DNA recombination
NP435_10760	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NP435_10795	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
NP435_10800	COG0756	dUTP diphosphatase activity
NP435_10805	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP435_10835	COG1780	Probably involved in ribonucleotide reductase function
NP435_10925	COG0270	DNA (cytosine-5-)-methyltransferase activity
NP435_10935	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
NP435_10940	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
NP435_10965	COG3584	3D domain protein
NP435_10970	COG0587	DNA-directed DNA polymerase activity
NP435_10975	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NP435_10980	COG0358	DNA primase activity
NP435_10985	COG0305	Participates in initiation and elongation during chromosome replication
NP435_10995	COG2887	Belongs to the helicase family. UvrD subfamily
NP435_11025	COG3420	alginic acid biosynthetic process
NP435_11025	COG5434	Belongs to the glycosyl hydrolase 28 family
NP435_11030	COG4195	phage-related replication protein
NP435_11045	COG2135	peptidase activity
NP435_11050	COG1793	dna ligase
NP435_11105	COG4474	Belongs to the UPF0398 family
NP435_11115	COG1388	LysM domain
NP435_11135	COG3645	SOS response
NP435_11135	COG3646	Phage regulatory protein
NP435_11190	COG3655	Transcriptional regulator
NP435_11205	COG0582	viral genome integration into host DNA
NP435_11285	COG3655	Transcriptional regulator
NP435_11325	COG1395	domain, Protein
NP435_11340	COG0776	regulation of translation
NP435_11375	COG4373	Mu-like prophage FluMu protein gp28
NP435_11475	COG0582	viral genome integration into host DNA
NP435_11505	COG0739	heme binding
NP435_11505	COG0741	lytic transglycosylase activity
NP435_11505	COG1196	nuclear chromosome segregation
NP435_11515	COG2433	Pfam Transposase IS66
NP435_11525	COG4632	Exopolysaccharide biosynthesis protein
NP435_11525	COG5434	Belongs to the glycosyl hydrolase 28 family
NP435_11540	COG5632	N-Acetylmuramoyl-L-alanine amidase
NP435_11555	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NP435_11560	COG0463	Glycosyl transferase, family 2
NP435_11565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP435_11570	COG2274	protein secretion by the type I secretion system
NP435_11570	COG3271	cysteine-type peptidase activity
NP435_11585	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NP435_11615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
NP435_11630	COG5444	nuclease activity
NP435_11635	COG4282	regulation of fungal-type cell wall biogenesis
NP435_11650	COG1525	nuclease
NP435_11660	COG2746	aminoglycoside 3-N-acetyltransferase activity
NP435_11685	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
NP435_11695	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NP435_11700	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
NP435_11705	COG1846	Transcriptional regulator
NP435_11710	COG0534	Mate efflux family protein
NP435_11720	COG4698	Protein conserved in bacteria
NP435_11725	COG2755	lipolytic protein G-D-S-L family
NP435_11730	COG1999	signal sequence binding
NP435_11740	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
NP435_11745	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NP435_11750	COG1272	protein, Hemolysin III
NP435_11755	COG0204	Acyl-transferase
NP435_11760	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NP435_11770	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NP435_11780	COG2521	methyltransferase
NP435_11780	COG2136	Putative SAM-dependent methyltransferase
NP435_11790	COG0129	dihydroxy-acid dehydratase activity
NP435_11795	COG1413	lyase activity
NP435_11800	COG1418	mRNA catabolic process
NP435_11805	COG0386	Belongs to the glutathione peroxidase family
NP435_11810	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
NP435_11815	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
NP435_11825	COG1278	Cold shock
NP435_11845	COG0328	RNA-DNA hybrid ribonuclease activity
NP435_11850	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
NP435_11855	COG0328	RNA-DNA hybrid ribonuclease activity
NP435_11865	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NP435_11880	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NP435_11890	COG1755	Isoprenylcysteine carboxyl methyltransferase
NP435_11895	COG3424	synthase
NP435_11900	COG2233	PERMEase
NP435_11905	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NP435_11910	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
NP435_11920	COG0800	Aldolase
NP435_11925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP435_11930	COG1609	Transcriptional regulator
NP435_11935	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
NP435_11940	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_11945	COG1199	ATP-dependent helicase activity
NP435_11960	COG0116	Belongs to the methyltransferase superfamily
NP435_11975	COG4474	Belongs to the UPF0398 family
NP435_11990	COG3359	exonuclease
NP435_11995	COG1111	helicase
NP435_11995	COG1205	dead DEAH box helicase
NP435_12000	COG2190	(PTS) system
NP435_12005	COG0071	Belongs to the small heat shock protein (HSP20) family
NP435_12040	COG3331	DNA recombination
NP435_12045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP435_12045	COG4499	WXG100 protein secretion system (Wss), protein YukC
NP435_12055	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
NP435_12060	COG3935	DnaD domain protein
NP435_12065	COG0017	Asparaginyl-tRNA synthetase
NP435_12070	COG0436	Aminotransferase
NP435_12075	COG5353	protein conserved in bacteria
NP435_12085	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
NP435_12085	COG1199	ATP-dependent helicase activity
NP435_12090	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
NP435_12095	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
NP435_12100	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
NP435_12105	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
NP435_12105	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
NP435_12110	COG0617	tRNA 3'-terminal CCA addition
NP435_12115	COG0438	transferase activity, transferring glycosyl groups
NP435_12120	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
NP435_12125	COG1803	Methylglyoxal synthase
NP435_12130	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
NP435_12135	COG1694	Mazg nucleotide pyrophosphohydrolase
NP435_12140	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP435_12150	COG4347	Protein of unknown function (DUF1405)
NP435_12155	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NP435_12155	COG2010	Cytochrome c
NP435_12160	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
NP435_12165	COG0723	plastoquinol--plastocyanin reductase activity
NP435_12175	COG5582	Belongs to the UPF0302 family
NP435_12180	COG0457	Tetratricopeptide repeat
NP435_12185	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
NP435_12190	COG0287	Prephenate dehydrogenase
NP435_12195	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
NP435_12200	COG0159	tryptophan synthase activity
NP435_12205	COG0133	tryptophan synthase activity
NP435_12210	COG0135	phosphoribosylanthranilate isomerase activity
NP435_12220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
NP435_12225	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
NP435_12230	COG4401	Chorismate mutase type I
NP435_12235	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
NP435_12240	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
NP435_12245	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
NP435_12250	COG0105	UTP biosynthetic process
NP435_12255	COG0142	geranyltranstransferase activity
NP435_12260	COG2226	methyltransferase
NP435_12265	COG0142	geranyltranstransferase activity
NP435_12275	COG0302	gtp cyclohydrolase
NP435_12280	COG0776	regulation of translation
NP435_12285	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
NP435_12300	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
NP435_12305	COG1160	GTP binding
NP435_12330	COG1304	FMN binding
NP435_12335	COG0539	negative regulation of cytoplasmic translation
NP435_12340	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
NP435_12350	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
NP435_12355	COG2959	enzyme of heme biosynthesis
NP435_12360	COG3409	Peptidoglycan-binding domain 1 protein
NP435_12360	COG3773	Cell wall hydrolase
NP435_12365	COG2339	peptidase activity
NP435_12370	COG0492	ferredoxin-NADP+ reductase activity
NP435_12375	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NP435_12380	COG4862	establishment of competence for transformation
NP435_12385	COG1408	metallophosphoesterase
NP435_12395	COG1388	LysM domain
NP435_12400	COG1266	CAAX protease self-immunity
NP435_12405	COG0514	ATP-dependent DNA helicase (RecQ)
NP435_12410	COG4955	Helix-turn-helix domain
NP435_12415	COG1141	Ferredoxin
NP435_12420	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
NP435_12425	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
NP435_12430	COG0710	3-dehydroquinate dehydratase activity
NP435_12440	COG1595	DNA-templated transcription, initiation
NP435_12445	COG5002	protein histidine kinase activity
NP435_12450	COG0745	RESPONSE REGULATOR receiver
NP435_12455	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NP435_12460	COG1333	cytochrome c biogenesis protein
NP435_12465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP435_12470	COG1187	pseudouridine synthase activity
NP435_12475	COG0700	Nucleoside recognition
NP435_12480	COG2715	membrane protein required for spore maturation
NP435_12485	COG1686	Belongs to the peptidase S11 family
NP435_12495	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
NP435_12500	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
NP435_12505	COG1547	Domain of unknown function (DUF309)
NP435_12510	COG0456	acetyltransferase
NP435_12515	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
NP435_12520	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NP435_12520	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
NP435_12525	COG0307	riboflavin synthase, alpha
NP435_12530	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NP435_12530	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
NP435_12540	COG0681	Belongs to the peptidase S26 family
NP435_12550	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
NP435_12565	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
NP435_12570	COG4086	secreted protein
NP435_12575	COG0019	diaminopimelate decarboxylase activity
NP435_12580	COG0697	spore germination
NP435_12595	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
NP435_12615	COG1191	sigma factor activity
NP435_12620	COG2172	sigma factor antagonist activity
NP435_12625	COG1366	Belongs to the anti-sigma-factor antagonist family
NP435_12630	COG1686	Belongs to the peptidase S11 family
NP435_12635	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
NP435_12640	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
NP435_12655	COG4974	Belongs to the 'phage' integrase family
NP435_12665	COG0735	belongs to the Fur family
NP435_12670	COG1300	Membrane
NP435_12680	COG0281	malic enzyme
NP435_12685	COG1757	Na H antiporter
NP435_12690	COG1027	Aspartate ammonia-lyase
NP435_12695	COG0252	asparaginase activity
NP435_12700	COG1396	sequence-specific DNA binding
NP435_12705	COG1379	DNA repair
NP435_12710	COG0494	nUDIX hydrolase
NP435_12720	COG0667	Aldo Keto reductase
NP435_12730	COG1073	alpha beta
NP435_12740	COG4918	Iron-sulphur cluster biosynthesis
NP435_12745	COG0456	acetyltransferase
NP435_12745	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
NP435_12750	COG2329	Antibiotic biosynthesis monooxygenase
NP435_12755	COG0456	acetyltransferase
NP435_12765	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NP435_12775	COG2211	Major facilitator Superfamily
NP435_12785	COG0346	lactoylglutathione lyase activity
NP435_12790	COG1072	(Pantothenic acid kinase))
NP435_12795	COG3048	D-serine ammonia-lyase activity
NP435_12800	COG0300	oxidoreductase activity
NP435_12805	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP435_12810	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NP435_12815	COG4187	Peptidase family M20/M25/M40
NP435_12820	COG1902	pentaerythritol trinitrate reductase activity
NP435_12825	COG0596	Alpha beta hydrolase
NP435_12835	COG1234	tRNA 3'-trailer cleavage
NP435_12840	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
NP435_12845	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NP435_12850	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
NP435_12860	COG0706	membrane insertase activity
NP435_12865	COG3361	conserved protein (COG2071)
NP435_12870	COG2195	Cleaves the N-terminal amino acid of tripeptides
NP435_12875	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
NP435_12880	COG0346	lactoylglutathione lyase activity
NP435_12890	COG1376	ErfK ybiS ycfS ynhG family protein
NP435_12895	COG4129	membrane
NP435_12900	COG1126	abc transporter atp-binding protein
NP435_12905	COG0765	amino acid transport
NP435_12910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP435_12920	COG1597	lipid kinase activity
NP435_12925	COG2814	Major facilitator Superfamily
NP435_12930	COG0789	Transcriptional regulator
NP435_12930	COG4978	Transcriptional regulator
NP435_12935	COG0508	dehydrogenase complex catalyzes the overall conversion of
NP435_12940	COG0022	dehydrogenase e1 component
NP435_12945	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
NP435_12950	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
NP435_12955	COG3426	butyrate kinase activity
NP435_12960	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NP435_12965	COG0280	phosphate acetyltransferase
NP435_12970	COG3290	protein histidine kinase activity
NP435_12970	COG3829	transcription factor binding
NP435_12980	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
NP435_12985	COG2079	MmgE PrpD family protein
NP435_12990	COG0372	Belongs to the citrate synthase family
NP435_12995	COG1960	acyl-CoA dehydrogenase activity
NP435_13000	COG1250	3-hydroxyacyl-CoA dehydrogenase
NP435_13005	COG0183	Belongs to the thiolase family
NP435_13010	COG0584	glycerophosphoryl diester phosphodiesterase
NP435_13015	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP435_13030	COG1902	pentaerythritol trinitrate reductase activity
NP435_13035	COG0745	RESPONSE REGULATOR receiver
NP435_13040	COG0750	zinc metalloprotease
NP435_13045	COG0497	DNA recombination
NP435_13050	COG1438	arginine binding
NP435_13055	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
NP435_13060	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
NP435_13065	COG0142	geranyltranstransferase activity
NP435_13070	COG1722	exodeoxyribonuclease VII activity
NP435_13075	COG1570	exodeoxyribonuclease VII activity
NP435_13080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
NP435_13085	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
NP435_13090	COG1302	Protein conserved in bacteria
NP435_13095	COG0439	Biotin carboxylase
NP435_13100	COG0511	ligase activity, forming carbon-carbon bonds
NP435_13140	COG3854	ATPases associated with a variety of cellular activities
NP435_13150	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
NP435_13155	COG0006	proline dipeptidase activity
NP435_13160	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
NP435_13170	COG3872	metal-dependent enzyme
NP435_13180	COG1752	Esterase of the alpha-beta hydrolase superfamily
NP435_13185	COG1321	iron dependent repressor
NP435_13190	COG0095	Lipoate-protein ligase
NP435_13195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NP435_13200	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NP435_13205	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
NP435_13210	COG0404	The glycine cleavage system catalyzes the degradation of glycine
NP435_13215	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NP435_13230	COG1396	sequence-specific DNA binding
NP435_13240	COG0681	Belongs to the peptidase S26 family
NP435_13265	COG4940	Competence protein ComGF
NP435_13275	COG4970	Tfp pilus assembly protein FimT
NP435_13280	COG4537	Required for transformation and DNA binding
NP435_13285	COG1459	type II secretion system
NP435_13290	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
NP435_13295	COG0598	Magnesium transport protein CorA
NP435_13300	COG1253	flavin adenine dinucleotide binding
NP435_13305	COG1366	Belongs to the anti-sigma-factor antagonist family
NP435_13315	COG1393	Belongs to the ArsC family
NP435_13325	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP435_13335	COG0011	TIGRFAM Protein of
NP435_13345	COG2866	Carboxypeptidase
NP435_13350	COG1368	sulfuric ester hydrolase activity
NP435_13355	COG1940	carbohydrate kinase activity
NP435_13360	COG4483	Protein conserved in bacteria
NP435_13365	COG0457	Tetratricopeptide repeat
NP435_13365	COG0705	Rhomboid family
NP435_13375	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
NP435_13385	COG0438	transferase activity, transferring glycosyl groups
NP435_13400	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NP435_13405	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NP435_13410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
NP435_13415	COG0581	inorganic phosphate transmembrane transporter activity
NP435_13420	COG0573	inorganic phosphate transmembrane transporter activity
NP435_13425	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
NP435_13430	COG0768	penicillin binding
NP435_13435	COG0477	Major facilitator Superfamily
NP435_13440	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
NP435_13445	COG2839	Protein conserved in bacteria
NP435_13450	COG5521	maltodextrose utilization protein MalA
NP435_13460	COG1388	LysM domain
NP435_13465	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
NP435_13470	COG4709	membrane
NP435_13475	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
NP435_13480	COG0735	belongs to the Fur family
NP435_13485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP435_13495	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
NP435_13500	COG0513	Belongs to the DEAD box helicase family
NP435_13510	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
NP435_13515	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
NP435_13520	COG2384	SAM-dependent methyltransferase
NP435_13525	COG2010	Cytochrome c
NP435_13530	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
NP435_13535	COG0358	DNA primase activity
NP435_13540	COG1671	Belongs to the UPF0178 family
NP435_13545	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
NP435_13550	COG0517	IMP dehydrogenase activity
NP435_13555	COG0751	glycine-tRNA ligase activity
NP435_13560	COG0752	glycyl-tRNA synthetase alpha subunit
NP435_13565	COG1381	Involved in DNA repair and RecF pathway recombination
NP435_13575	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
NP435_13580	COG0295	cytidine deaminase activity
NP435_13585	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
NP435_13590	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
NP435_13595	COG1480	7TM receptor with intracellular HD hydrolase
NP435_13600	COG1702	phosphate starvation-inducible protein PhoH
NP435_13605	COG0561	phosphatase activity
NP435_13620	COG4864	UPF0365 protein
NP435_13625	COG1030	water channel activity
NP435_13630	COG1610	YqeY-like protein
NP435_13640	COG1283	sodium-dependent phosphate transmembrane transporter activity
NP435_13645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
NP435_13650	COG1385	rRNA (uridine-N3-)-methyltransferase activity
NP435_13655	COG2264	protein methyltransferase activity
NP435_13660	COG0484	heat shock protein binding
NP435_13665	COG0443	Heat shock 70 kDa protein
NP435_13670	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
NP435_13675	COG1420	regulation of RNA biosynthetic process
NP435_13680	COG0635	Involved in the biosynthesis of porphyrin-containing compound
NP435_13685	COG0481	GTPase activity
NP435_13695	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP435_13700	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
NP435_13705	COG0268	Binds directly to 16S ribosomal RNA
NP435_13710	COG1466	dna polymerase III delta subunit
NP435_13725	COG0658	competence protein
NP435_13725	COG2333	competence protein COMEC
NP435_13730	COG2131	deaminase
NP435_13735	COG1555	photosystem II stabilization
NP435_13735	COG1596	polysaccharide export
NP435_13740	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
NP435_13745	COG2226	methyltransferase
NP435_13750	COG0799	negative regulation of ribosome biogenesis
NP435_13755	COG1713	HD superfamily hydrolase involved in NAD metabolism
NP435_13760	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
NP435_13765	COG1534	Rna-binding protein
NP435_13770	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
NP435_13775	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
NP435_13780	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
NP435_13790	COG2755	lipolytic protein G-D-S-L family
NP435_13795	COG3409	Peptidoglycan-binding domain 1 protein
NP435_13795	COG5632	N-Acetylmuramoyl-L-alanine amidase
NP435_13800	COG0398	Pfam SNARE associated Golgi protein
NP435_13805	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
NP435_13815	COG3209	COG3209 Rhs family protein
NP435_13840	COG3223	Belongs to the PsiE family
NP435_13845	COG0642	Histidine kinase
NP435_13845	COG5002	protein histidine kinase activity
NP435_13850	COG0745	RESPONSE REGULATOR receiver
NP435_13855	COG2311	Membrane
NP435_13865	COG0454	-acetyltransferase
NP435_13870	COG2249	NAD(P)H dehydrogenase (quinone) activity
NP435_13880	COG0730	response to heat
NP435_13885	COG0425	Belongs to the sulfur carrier protein TusA family
NP435_13890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP435_13890	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NP435_13900	COG0425	Belongs to the sulfur carrier protein TusA family
NP435_13900	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NP435_13910	COG2210	Belongs to the sulfur carrier protein TusA family
NP435_13915	COG1937	Protein conserved in bacteria
NP435_13925	COG0662	Cupin 2, conserved barrel domain protein
NP435_13940	COG0789	Transcriptional regulator
NP435_13940	COG4978	Transcriptional regulator
NP435_13945	COG2814	Major facilitator Superfamily
NP435_13950	COG0456	acetyltransferase
NP435_13955	COG1253	flavin adenine dinucleotide binding
NP435_13965	COG0697	spore germination
NP435_13970	COG0583	DNA-binding transcription factor activity
NP435_13975	COG2072	flavoprotein involved in K transport
NP435_13980	COG1230	cation diffusion facilitator family transporter
NP435_13985	COG1942	4-Oxalocrotonate Tautomerase
NP435_13990	COG0583	DNA-binding transcription factor activity
NP435_14000	COG1114	Component of the transport system for branched-chain amino acids
NP435_14005	COG1687	branched-chain amino acid
NP435_14010	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
NP435_14015	COG1522	sequence-specific DNA binding
NP435_14020	COG2732	(Barnase) inhibitor
NP435_14025	COG2124	cytochrome p450
NP435_14035	COG1335	isochorismatase
NP435_14050	COG2318	DinB family
NP435_14060	COG2070	2-Nitropropane dioxygenase
NP435_14065	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NP435_14085	COG3443	Belongs to the bacterial solute-binding protein 9 family
NP435_14090	COG1595	DNA-templated transcription, initiation
NP435_14095	COG0667	Aldo Keto reductase
NP435_14100	COG2851	Citrate transporter
NP435_14105	COG0583	DNA-binding transcription factor activity
NP435_14110	COG2828	Protein conserved in bacteria
NP435_14115	COG3409	Peptidoglycan-binding domain 1 protein
NP435_14120	COG5566	PFAM Mor transcription activator
NP435_14125	COG0596	Alpha beta hydrolase
NP435_14130	COG4991	sh3 domain protein
NP435_14135	COG4991	sh3 domain protein
NP435_14145	COG0346	lactoylglutathione lyase activity
NP435_14155	COG5577	PFAM Coat F domain
NP435_14160	COG1063	alcohol dehydrogenase
NP435_14170	COG5577	PFAM Coat F domain
NP435_14175	COG0789	Transcriptional regulator
NP435_14185	COG1064	alcohol dehydrogenase
NP435_14190	COG0693	protein deglycase activity
NP435_14195	COG1621	beta-fructofuranosidase activity
NP435_14205	COG3716	PTS system mannose fructose sorbose family IID component
NP435_14210	COG3715	PTS system
NP435_14215	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP435_14220	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP435_14225	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
NP435_14225	COG3933	PFAM sigma-54 factor interaction domain-containing protein
NP435_14235	COG1113	amino acid transport
NP435_14240	COG1280	lysine exporter protein (LysE YggA)
NP435_14245	COG1378	Sugar-specific transcriptional regulator TrmB
NP435_14250	COG1595	DNA-templated transcription, initiation
NP435_14260	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
NP435_14260	COG2755	lipolytic protein G-D-S-L family
NP435_14270	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NP435_14270	COG2124	cytochrome p450
NP435_14275	COG1309	transcriptional regulator
NP435_14280	COG2226	methyltransferase
NP435_14295	COG2116	formate transmembrane transporter activity
NP435_14300	COG5609	conserved protein (DUF2294)
NP435_14305	COG3383	formate dehydrogenase (NAD+) activity
NP435_14310	COG2427	Protein of unknown function (DUF1641)
NP435_14320	COG0626	cystathionine gamma-synthase activity
NP435_14325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NP435_14330	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
NP435_14335	COG2226	methyltransferase
NP435_14350	COG0768	penicillin binding
NP435_14355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
NP435_14360	COG0572	uridine kinase
NP435_14365	COG0826	peptidase U32
NP435_14370	COG0826	peptidase U32
NP435_14375	COG4122	O-methyltransferase activity
NP435_14380	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
NP435_14385	COG3906	Belongs to the UPF0473 family
NP435_14390	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
NP435_14395	COG4472	Bacterial protein of unknown function (DUF965)
NP435_14400	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
NP435_14405	COG0628	permease
NP435_14410	COG1126	abc transporter atp-binding protein
NP435_14415	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP435_14420	COG0765	amino acid transport
NP435_14425	COG0765	amino acid transport
NP435_14440	COG3881	PFAM PRC-barrel domain
NP435_14445	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
NP435_14450	COG0457	Tetratricopeptide repeat
NP435_14455	COG0482	sulfurtransferase activity
NP435_14460	COG1104	cysteine desulfurase activity
NP435_14465	COG1959	2 iron, 2 sulfur cluster binding
NP435_14470	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
NP435_14475	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
NP435_14485	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
NP435_14490	COG0124	histidyl-tRNA synthetase
NP435_14500	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP435_14500	COG3103	Sh3 type 3 domain protein
NP435_14500	COG4991	sh3 domain protein
NP435_14510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
NP435_14515	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
NP435_14520	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
NP435_14520	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
NP435_14525	COG5416	Lipopolysaccharide assembly protein A domain
NP435_14530	COG0490	domain, Protein
NP435_14535	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NP435_14535	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
NP435_14545	COG2244	polysaccharide biosynthetic process
NP435_14550	COG2323	membrane
NP435_14560	COG1862	Preprotein translocase
NP435_14565	COG0343	queuine tRNA-ribosyltransferase activity
NP435_14570	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
NP435_14580	COG2255	four-way junction helicase activity
NP435_14585	COG0632	four-way junction helicase activity
NP435_14595	COG2814	Major facilitator Superfamily
NP435_14600	COG0673	inositol 2-dehydrogenase activity
NP435_14605	COG2112	serine threonine protein kinase
NP435_14625	COG1115	amino acid carrier protein
NP435_14630	COG0217	transcriptional regulatory protein
NP435_14640	COG1388	LysM domain
NP435_14645	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
NP435_14650	COG0157	Belongs to the NadC ModD family
NP435_14655	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
NP435_14660	COG1104	cysteine desulfurase activity
NP435_14665	COG1827	regulation of RNA biosynthetic process
NP435_14670	COG0077	Prephenate dehydratase
NP435_14675	COG4492	Belongs to the UPF0735 family
NP435_14680	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
NP435_14685	COG3290	protein histidine kinase activity
NP435_14695	COG0211	Belongs to the bacterial ribosomal protein bL27 family
NP435_14700	COG2868	ribosomal protein
NP435_14705	COG0261	This protein binds to 23S rRNA in the presence of protein L20
NP435_14710	COG1994	Peptidase M50
NP435_14715	COG0739	heme binding
NP435_14720	COG2894	cell division
NP435_14725	COG0850	regulation of cytokinetic process
NP435_14730	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
NP435_14740	COG1077	Cell shape determining protein MreB Mrl
NP435_14745	COG2003	Belongs to the UPF0758 family
NP435_14750	COG0424	maF-like protein
NP435_14760	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
NP435_14765	COG0285	dihydrofolate synthase activity
NP435_14770	COG0525	valine-tRNA ligase activity
NP435_14780	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NP435_14785	COG1388	LysM domain
NP435_14790	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
NP435_14795	COG0113	porphobilinogen synthase activity
NP435_14800	COG1587	Uroporphyrinogen-III synthase
NP435_14805	COG0181	hydroxymethylbilane synthase activity
NP435_14810	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
NP435_14815	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
NP435_14825	COG0218	Necessary for normal cell division and for the maintenance of normal septation
NP435_14830	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
NP435_14835	COG0470	DNA polymerase III
NP435_14835	COG1067	ATP-dependent peptidase activity
NP435_14840	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
NP435_14845	COG0544	peptidyl-prolyl cis-trans isomerase activity
NP435_14850	COG0457	Tetratricopeptide repeat
NP435_14850	COG1477	protein flavinylation
NP435_14855	COG0066	3-isopropylmalate dehydratase activity
NP435_14860	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
NP435_14865	COG0473	3-isopropylmalate dehydrogenase activity
NP435_14870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
NP435_14875	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
NP435_14880	COG0440	acetolactate synthase activity
NP435_14885	COG0028	Belongs to the TPP enzyme family
NP435_14895	COG0454	-acetyltransferase
NP435_14900	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
NP435_14910	COG0622	Phosphoesterase
NP435_14915	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
NP435_14920	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
NP435_14925	COG5401	PFAM Sporulation and spore germination
NP435_14930	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
NP435_14935	COG1846	Transcriptional regulator
NP435_14940	COG2197	response regulator
NP435_14945	COG0824	Thioesterase
NP435_14950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
NP435_14955	COG1053	succinate dehydrogenase
NP435_14960	COG2009	succinate dehydrogenase
NP435_14965	COG1719	4-vinyl reductase, 4VR
NP435_14970	COG0527	aspartate kinase activity
NP435_14975	COG0322	excinuclease ABC activity
NP435_14980	COG3118	belongs to the thioredoxin family
NP435_14985	COG3534	alpha-L-arabinofuranosidase
NP435_14990	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
NP435_14995	COG2086	electron transfer activity
NP435_15000	COG1024	Enoyl-CoA hydratase
NP435_15005	COG1309	transcriptional regulator
NP435_15010	COG0318	PFAM AMP-dependent synthetase and ligase
NP435_15015	COG3766	membrane
NP435_15020	COG1193	negative regulation of DNA recombination
NP435_15025	COG1796	DNA polymerase
NP435_15025	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NP435_15030	COG1286	toxin biosynthetic process
NP435_15035	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
NP435_15040	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
NP435_15045	COG0072	phenylalanine-tRNA ligase activity
NP435_15045	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP435_15050	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
NP435_15060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
NP435_15070	COG3835	regulator
NP435_15075	COG0277	FAD linked oxidase domain protein
NP435_15080	COG0247	lactate metabolic process
NP435_15085	COG0346	lactoylglutathione lyase activity
NP435_15095	COG1966	Carbon starvation protein
NP435_15100	COG3534	alpha-L-arabinofuranosidase
NP435_15105	COG0395	ABC-type sugar transport system, permease component
NP435_15110	COG1175	transmembrane transport
NP435_15115	COG1653	transport
NP435_15120	COG0371	Dehydrogenase
NP435_15125	COG0647	UMP catabolic process
NP435_15130	COG0235	Class ii aldolase
NP435_15135	COG1069	ribulokinase activity
NP435_15140	COG2160	L-arabinose isomerase activity
NP435_15145	COG3507	Belongs to the glycosyl hydrolase 43 family
NP435_15150	COG1363	Peptidase, m42
NP435_15160	COG3326	Membrane
NP435_15165	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
NP435_15170	COG0291	Belongs to the bacterial ribosomal protein bL35 family
NP435_15175	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
NP435_15185	COG1346	cytolysis
NP435_15190	COG1380	Effector of murein hydrolase LrgA
NP435_15195	COG3279	Response regulator of the LytR AlgR family
NP435_15200	COG3275	phosphorelay sensor kinase activity
NP435_15205	COG1011	Hydrolase
NP435_15210	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NP435_15220	COG0398	Pfam SNARE associated Golgi protein
NP435_15225	COG1484	DNA-dependent DNA replication
NP435_15230	COG3611	Membrane attachment protein
NP435_15235	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
NP435_15240	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
NP435_15245	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NP435_15250	COG1733	regulation of RNA biosynthetic process
NP435_15255	COG2814	Major facilitator Superfamily
NP435_15260	COG0656	L-ascorbic acid biosynthetic process
NP435_15265	COG0237	dephospho-CoA kinase activity
NP435_15275	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
NP435_15280	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NP435_15280	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
NP435_15285	COG5002	protein histidine kinase activity
NP435_15290	COG0745	RESPONSE REGULATOR receiver
NP435_15295	COG0039	L-malate dehydrogenase activity
NP435_15300	COG0538	isocitrate dehydrogenase activity
NP435_15305	COG0372	Belongs to the citrate synthase family
NP435_15310	COG2707	UPF0756 membrane protein
NP435_15315	COG0628	permease
NP435_15320	COG3030	protein affecting phage T7 exclusion by the F plasmid
NP435_15325	COG0469	pyruvate kinase activity
NP435_15330	COG0205	6-phosphofructokinase activity
NP435_15335	COG0825	malonyl-CoA metabolic process
NP435_15340	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
NP435_15345	COG0281	malic enzyme
NP435_15350	COG0587	DNA-directed DNA polymerase activity
NP435_15370	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
NP435_15380	COG4109	DRTGG domain
NP435_15385	COG0730	response to heat
NP435_15390	COG1473	amidohydrolase
NP435_15395	COG0196	riboflavin kinase activity
NP435_15400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP435_15405	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
NP435_15410	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP435_15415	COG1126	abc transporter atp-binding protein
NP435_15420	COG0765	amino acid transport
NP435_15425	COG0765	amino acid transport
NP435_15430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP435_15435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP435_15440	COG0454	-acetyltransferase
NP435_15445	COG0583	DNA-binding transcription factor activity
NP435_15450	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
NP435_15455	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_15465	COG0165	Argininosuccinate lyase
NP435_15470	COG0137	argininosuccinate synthase activity
NP435_15475	COG0521	Mo-molybdopterin cofactor biosynthetic process
NP435_15480	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
NP435_15490	COG0827	DNA restriction-modification system
NP435_15495	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
NP435_15500	COG3874	Sporulation protein YtfJ
NP435_15510	COG1714	RDD family
NP435_15515	COG0616	signal peptide processing
NP435_15520	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
NP435_15525	COG1574	metal-dependent hydrolase with the TIM-barrel fold
NP435_15530	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NP435_15540	COG0301	tRNA thio-modification
NP435_15545	COG1104	cysteine desulfurase activity
NP435_15550	COG1114	Component of the transport system for branched-chain amino acids
NP435_15555	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
NP435_15560	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
NP435_15565	COG1309	transcriptional regulator
NP435_15570	COG1956	GAF domain-containing protein
NP435_15575	COG2199	diguanylate cyclase activity
NP435_15575	COG2203	Gaf domain
NP435_15580	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
NP435_15585	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NP435_15590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
NP435_15595	COG0454	-acetyltransferase
NP435_15600	COG0517	IMP dehydrogenase activity
NP435_15605	COG0123	including yeast histone deacetylase and acetoin utilization protein
NP435_15610	COG1360	Flagellar Motor Protein
NP435_15615	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
NP435_15620	COG1609	Transcriptional regulator
NP435_15625	COG1605	Chorismate mutase
NP435_15625	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
NP435_15630	COG3118	belongs to the thioredoxin family
NP435_15635	COG4980	gas vesicle protein
NP435_15640	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
NP435_15645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
NP435_15650	COG1674	ftsk spoiiie
NP435_15655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
NP435_15660	COG4848	Belongs to the UPF0354 family
NP435_15665	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP435_15680	COG1363	Peptidase, m42
NP435_15685	COG5584	Small secreted protein
NP435_15690	COG0281	malic enzyme
NP435_15695	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP435_15700	COG0220	tRNA (guanine-N7-)-methyltransferase activity
NP435_15710	COG0510	thiamine kinase activity
NP435_15715	COG1523	belongs to the glycosyl hydrolase 13 family
NP435_15720	COG1597	lipid kinase activity
NP435_15730	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
NP435_15735	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
NP435_15740	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NP435_15745	COG2252	PERMEase
NP435_15750	COG4473	ABC transporter
NP435_15755	COG1131	(ABC) transporter
NP435_15760	COG1349	DNA-binding transcription factor activity
NP435_15765	COG1187	pseudouridine synthase activity
NP435_15770	COG2244	polysaccharide biosynthetic process
NP435_15775	COG2081	HI0933 family
NP435_15780	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
NP435_15790	COG5578	integral membrane protein
NP435_15795	COG0673	inositol 2-dehydrogenase activity
NP435_15800	COG1653	transport
NP435_15805	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
NP435_15810	COG4209	transmembrane transport
NP435_15815	COG2207	Transcriptional regulator
NP435_15820	COG1653	transport
NP435_15825	COG0395	ABC-type sugar transport system, permease component
NP435_15830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NP435_15835	COG2124	cytochrome p450
NP435_15840	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
NP435_15845	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
NP435_15850	COG0156	8-amino-7-oxononanoate synthase activity
NP435_15855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
NP435_15860	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
NP435_15865	COG1073	alpha beta
NP435_15870	COG1609	Transcriptional regulator
NP435_15875	COG1653	transport
NP435_15880	COG1175	transmembrane transport
NP435_15885	COG0395	ABC-type sugar transport system, permease component
NP435_15890	COG1486	melibiose metabolic process
NP435_15895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
NP435_15900	COG0495	leucyl-tRNA aminoacylation
NP435_15910	COG1366	Belongs to the anti-sigma-factor antagonist family
NP435_15910	COG2202	Pas domain
NP435_15915	COG2814	Major facilitator Superfamily
NP435_15920	COG2433	Pfam Transposase IS66
NP435_15925	COG0577	efflux transmembrane transporter activity
NP435_15930	COG1136	(ABC) transporter
NP435_15935	COG2205	protein histidine kinase activity
NP435_15940	COG0745	RESPONSE REGULATOR receiver
NP435_15945	COG0577	efflux transmembrane transporter activity
NP435_15950	COG1136	(ABC) transporter
NP435_15965	COG1131	(ABC) transporter
NP435_15970	COG1725	Transcriptional regulator
NP435_15985	COG1242	4 iron, 4 sulfur cluster binding
NP435_15990	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
NP435_16000	COG2267	carboxylic ester hydrolase activity
NP435_16005	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
NP435_16010	COG1113	amino acid transport
NP435_16015	COG0367	asparagine synthase
NP435_16020	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
NP435_16025	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
NP435_16035	COG1506	peptidase
NP435_16040	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
NP435_16045	COG1116	anion transmembrane transporter activity
NP435_16050	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
NP435_16055	COG0494	nUDIX hydrolase
NP435_16060	COG4824	toxin secretion phage lysis holin
NP435_16065	COG0783	Belongs to the Dps family
NP435_16080	COG1854	S-ribosylhomocysteine lyase activity
NP435_16085	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
NP435_16090	COG0288	reversible hydration of carbon dioxide
NP435_16095	COG0254	rRNA binding
NP435_16100	COG1271	oxidase subunit
NP435_16105	COG1294	oxidase, subunit
NP435_16115	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NP435_16120	COG1108	ABC-type Mn2 Zn2 transport systems permease components
NP435_16120	COG1321	iron dependent repressor
NP435_16125	COG1121	(ABC) transporter
NP435_16130	COG0803	Belongs to the bacterial solute-binding protein 9 family
NP435_16135	COG4948	Mandelate Racemase Muconate Lactonizing
NP435_16140	COG0318	PFAM AMP-dependent synthetase and ligase
NP435_16145	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
NP435_16150	COG0596	Alpha beta hydrolase
NP435_16155	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
NP435_16160	COG1169	isochorismate synthase
NP435_16165	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
NP435_16170	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NP435_16175	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NP435_16180	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
NP435_16185	COG0438	transferase activity, transferring glycosyl groups
NP435_16195	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NP435_16200	COG0438	transferase activity, transferring glycosyl groups
NP435_16205	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NP435_16210	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
NP435_16215	COG0058	SHG alpha-glucan phosphorylase activity
NP435_16220	COG0297	glycogen (starch) synthase activity
NP435_16225	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NP435_16230	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
NP435_16235	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
NP435_16360	COG3859	Proton-coupled thiamine transporter YuaJ
NP435_16365	COG1247	-acetyltransferase
NP435_16370	COG2268	Band 7 protein
NP435_16375	COG1585	Membrane protein implicated in regulation of membrane protease activity
NP435_16380	COG2318	DinB family
NP435_16390	COG1454	alcohol dehydrogenase
NP435_16395	COG1012	belongs to the aldehyde dehydrogenase family
NP435_16400	COG1510	regulation of RNA biosynthetic process
NP435_16410	COG0569	domain protein
NP435_16415	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
NP435_16420	COG4682	membrane
NP435_16425	COG1705	Flagellar rod assembly protein muramidase FlgJ
NP435_16430	COG0477	Major facilitator Superfamily
NP435_16435	COG5553	Cysteine dioxygenase type I
NP435_16445	COG1968	undecaprenyl-diphosphatase activity
NP435_16450	COG0628	permease
NP435_16455	COG0673	inositol 2-dehydrogenase activity
NP435_16460	COG4806	L-rhamnose isomerase
NP435_16465	COG3254	rhamnose metabolic process
NP435_16470	COG1070	Carbohydrate kinase
NP435_16475	COG1349	DNA-binding transcription factor activity
NP435_16480	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_16480	COG3347	Dehydrogenase
NP435_16485	COG0840	transmembrane signaling receptor activity
NP435_16490	COG0840	transmembrane signaling receptor activity
NP435_16495	COG0840	transmembrane signaling receptor activity
NP435_16500	COG0840	transmembrane signaling receptor activity
NP435_16515	COG0432	Pfam Uncharacterised protein family UPF0047
NP435_16525	COG0366	Alpha amylase catalytic
NP435_16530	COG1253	flavin adenine dinucleotide binding
NP435_16535	COG2738	Putative neutral zinc metallopeptidase
NP435_16550	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
NP435_16565	COG0166	Belongs to the GPI family
NP435_16570	COG1979	alcohol dehydrogenase
NP435_16575	COG1979	alcohol dehydrogenase
NP435_16580	COG2155	Conserved Protein
NP435_16585	COG1098	S1 RNA binding domain
NP435_16590	COG0436	Aminotransferase
NP435_16595	COG1522	sequence-specific DNA binding
NP435_16600	COG2267	carboxylic ester hydrolase activity
NP435_16610	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
NP435_16615	COG2205	protein histidine kinase activity
NP435_16625	COG5018	Exonuclease
NP435_16635	COG2814	Major facilitator Superfamily
NP435_16640	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP435_16645	COG3011	Protein conserved in bacteria
NP435_16655	COG3290	protein histidine kinase activity
NP435_16660	COG4565	transcriptional regulatory protein
NP435_16665	COG1744	ABC transporter substrate-binding protein PnrA-like
NP435_16670	COG3845	ABC transporter
NP435_16675	COG4603	Belongs to the binding-protein-dependent transport system permease family
NP435_16680	COG1079	Belongs to the binding-protein-dependent transport system permease family
NP435_16685	COG3493	citrate carrier protein
NP435_16695	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
NP435_16695	COG2111	Na H antiporter
NP435_16700	COG2111	Na H antiporter
NP435_16705	COG1006	Multisubunit Na H antiporter MnhC subunit
NP435_16710	COG0651	ATP synthesis coupled electron transport
NP435_16715	COG1863	multisubunit Na H antiporter MnhE subunit
NP435_16720	COG2212	antiporter activity
NP435_16725	COG1320	monovalent cation:proton antiporter activity
NP435_16730	COG2050	protein possibly involved in aromatic compounds catabolism
NP435_16735	COG2197	response regulator
NP435_16740	COG4585	Histidine kinase
NP435_16750	COG0142	geranyltranstransferase activity
NP435_16770	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
NP435_16775	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
NP435_16780	COG1335	isochorismatase
NP435_16785	COG5506	Protein of unknown function (DUF1694)
NP435_16800	COG0628	permease
NP435_16815	COG1418	mRNA catabolic process
NP435_16820	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_16830	COG1511	domain protein
NP435_16835	COG0433	COG0433 Predicted ATPase
NP435_16835	COG1674	ftsk spoiiie
NP435_16840	COG4499	WXG100 protein secretion system (Wss), protein YukC
NP435_16845	COG5417	Belongs to the EsaB family
NP435_16850	COG4842	Belongs to the WXG100 family
NP435_16855	COG2508	Transcriptional regulator
NP435_16855	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
NP435_16860	COG0686	Belongs to the AlaDH PNT family
NP435_16865	COG5634	Uncharacterized conserved protein (DUF2278)
NP435_16870	COG3251	PFAM MbtH domain protein
NP435_16875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP435_16880	COG1535	isochorismatase
NP435_16880	COG3433	isochorismatase activity
NP435_16885	COG1021	2,3-dihydroxybenzoate-AMP ligase
NP435_16890	COG1169	isochorismate synthase
NP435_16895	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_16900	COG2819	hydrolase of the alpha beta superfamily
NP435_16905	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
NP435_16910	COG1268	BioY protein
NP435_16915	COG2056	Na+-H+ antiporter family
NP435_16920	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
NP435_16925	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
NP435_16930	COG3584	3D domain protein
NP435_16945	COG1252	NADH dehydrogenase
NP435_16950	COG0492	ferredoxin-NADP+ reductase activity
NP435_16960	COG0516	GMP reductase activity
NP435_16965	COG2808	Putative FMN-binding domain
NP435_16970	COG0456	acetyltransferase
NP435_16975	COG0316	Belongs to the HesB IscA family
NP435_16980	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
NP435_16985	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NP435_16990	COG4844	belongs to the
NP435_16995	COG1252	NADH dehydrogenase
NP435_17000	COG4837	Protein of unknown function (DUF1462)
NP435_17005	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
NP435_17010	COG4946	Tricorn protease homolog
NP435_17010	COG1506	peptidase
NP435_17010	COG0823	Involved in the tonB-independent uptake of proteins
NP435_17015	COG0083	homoserine kinase activity
NP435_17020	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
NP435_17025	COG0460	homoserine dehydrogenase
NP435_17030	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
NP435_17035	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
NP435_17040	COG0647	UMP catabolic process
NP435_17045	COG2445	Protein of unknown function DUF86
NP435_17050	COG4470	Protein conserved in bacteria
NP435_17060	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
NP435_17065	COG0739	heme binding
NP435_17075	COG3377	Domain of unknown function (DUF1805)
NP435_17080	COG0737	Belongs to the 5'-nucleotidase family
NP435_17085	COG0730	response to heat
NP435_17090	COG1801	Protein of unknown function DUF72
NP435_17100	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
NP435_17105	COG2508	Transcriptional regulator
NP435_17110	COG2233	PERMEase
NP435_17115	COG2233	PERMEase
NP435_17120	COG3195	allantoin biosynthetic process
NP435_17120	COG3648	Uricase
NP435_17125	COG2351	hydroxyisourate hydrolase activity
NP435_17135	COG2080	2 iron, 2 sulfur cluster binding
NP435_17140	COG1529	Aldehyde oxidase and xanthine dehydrogenase
NP435_17145	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
NP435_17150	COG2068	MobA-Related Protein
NP435_17155	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
NP435_17160	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
NP435_17165	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
NP435_17175	COG2356	endonuclease I
NP435_17180	COG3842	ATPase activity
NP435_17185	COG2188	Transcriptional regulator
NP435_17190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP435_17195	COG0395	ABC-type sugar transport system, permease component
NP435_17200	COG1175	transmembrane transport
NP435_17205	COG1653	transport
NP435_17210	COG2222	sugar isomerase
NP435_17215	COG0322	excinuclease ABC activity
NP435_17220	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
NP435_17235	COG0346	lactoylglutathione lyase activity
NP435_17240	COG0640	Transcriptional regulator
NP435_17245	COG0719	Fe-S assembly protein
NP435_17250	COG0822	iron-sulfur transferase activity
NP435_17255	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
NP435_17260	COG0719	Fe-S assembly protein
NP435_17265	COG0396	ATPase activity
NP435_17275	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
NP435_17280	COG1464	Belongs to the NlpA lipoprotein family
NP435_17285	COG2011	ABC-type metal ion transport system permease component
NP435_17290	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
NP435_17300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
NP435_17305	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
NP435_17315	COG0509	glycine decarboxylation via glycine cleavage system
NP435_17320	COG1393	Belongs to the ArsC family
NP435_17325	COG1960	acyl-CoA dehydrogenase activity
NP435_17330	COG0183	Belongs to the thiolase family
NP435_17335	COG1024	Enoyl-CoA hydratase
NP435_17335	COG1250	3-hydroxyacyl-CoA dehydrogenase
NP435_17345	COG0506	proline dehydrogenase activity
NP435_17355	COG5577	PFAM Coat F domain
NP435_17360	COG1846	Transcriptional regulator
NP435_17365	COG0477	Major facilitator Superfamily
NP435_17370	COG1942	4-Oxalocrotonate Tautomerase
NP435_17380	COG0583	DNA-binding transcription factor activity
NP435_17390	COG1120	ATPase activity
NP435_17405	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_17410	COG0783	Belongs to the Dps family
NP435_17415	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NP435_17420	COG0745	RESPONSE REGULATOR receiver
NP435_17425	COG2205	protein histidine kinase activity
NP435_17425	COG2770	Histidine kinase
NP435_17435	COG1309	transcriptional regulator
NP435_17440	COG0114	fumarate hydratase activity
NP435_17450	COG0697	spore germination
NP435_17455	COG0814	amino acid
NP435_17465	COG2197	response regulator
NP435_17470	COG4585	Histidine kinase
NP435_17475	COG4758	membrane
NP435_17480	COG3595	metallopeptidase activity
NP435_17485	COG1842	Phage shock protein A
NP435_17490	COG4758	membrane
NP435_17495	COG2814	Major facilitator Superfamily
NP435_17500	COG2096	Adenosyltransferase
NP435_17505	COG1120	ATPase activity
NP435_17510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP435_17515	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP435_17520	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_17525	COG3386	PFAM SMP-30 Gluconolaconase
NP435_17530	COG2205	protein histidine kinase activity
NP435_17535	COG0745	RESPONSE REGULATOR receiver
NP435_17545	COG1191	sigma factor activity
NP435_17555	COG2140	Oxalate decarboxylase
NP435_17565	COG0577	efflux transmembrane transporter activity
NP435_17570	COG1136	(ABC) transporter
NP435_17575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
NP435_17580	COG1120	ATPase activity
NP435_17585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP435_17590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
NP435_17595	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP435_17600	COG0531	amino acid
NP435_17610	COG1988	membrane-bound metal-dependent
NP435_17615	COG1368	sulfuric ester hydrolase activity
NP435_17620	COG1910	domain protein
NP435_17625	COG0725	ABC transporter, periplasmic molybdate-binding protein
NP435_17630	COG4149	molybdate abc transporter
NP435_17635	COG0656	L-ascorbic acid biosynthetic process
NP435_17645	COG0025	NhaP-type Na H and K H
NP435_17650	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
NP435_17655	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
NP435_17660	COG3973	AAA domain
NP435_17665	COG2860	membrane
NP435_17670	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
NP435_17675	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
NP435_17680	COG2217	Heavy metal translocating P-type atpase
NP435_17685	COG2217	Heavy metal translocating P-type atpase
NP435_17690	COG2608	mercury ion transmembrane transporter activity
NP435_17695	COG1937	Protein conserved in bacteria
NP435_17700	COG0673	inositol 2-dehydrogenase activity
NP435_17705	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
NP435_17710	COG1289	transmembrane transporter activity
NP435_17720	COG2076	Multidrug Resistance protein
NP435_17725	COG1309	transcriptional regulator
NP435_17730	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_17740	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
NP435_17745	COG0557	exoribonuclease II activity
NP435_17750	COG1647	Serine aminopeptidase, S33
NP435_17755	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
NP435_17760	COG0596	Alpha beta hydrolase
NP435_17765	COG1476	TRANSCRIPTIONal
NP435_17770	COG1396	sequence-specific DNA binding
NP435_17775	COG1396	sequence-specific DNA binding
NP435_17780	COG1733	regulation of RNA biosynthetic process
NP435_17785	COG0840	transmembrane signaling receptor activity
NP435_17790	COG1174	glycine betaine transport
NP435_17795	COG1732	Glycine betaine
NP435_17800	COG1174	glycine betaine transport
NP435_17805	COG0517	IMP dehydrogenase activity
NP435_17805	COG1125	glycine betaine transport
NP435_17810	COG1510	regulation of RNA biosynthetic process
NP435_17830	COG5658	integral membrane protein
NP435_17835	COG0640	Transcriptional regulator
NP435_17840	COG1174	glycine betaine transport
NP435_17845	COG1732	Glycine betaine
NP435_17850	COG1174	glycine betaine transport
NP435_17855	COG0517	IMP dehydrogenase activity
NP435_17855	COG1125	glycine betaine transport
NP435_17860	COG1510	regulation of RNA biosynthetic process
NP435_17865	COG2095	MarC family integral membrane protein
NP435_17875	COG3064	Membrane
NP435_17880	COG4640	response to antibiotic
NP435_17885	COG0456	acetyltransferase
NP435_17890	COG0148	phosphopyruvate hydratase activity
NP435_17895	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
NP435_17900	COG0149	triose-phosphate isomerase activity
NP435_17905	COG0126	phosphoglycerate kinase activity
NP435_17910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
NP435_17915	COG2390	Transcriptional regulator
NP435_17920	COG2814	Major facilitator Superfamily
NP435_17925	COG1609	Transcriptional regulator
NP435_17930	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP435_17935	COG0583	DNA-binding transcription factor activity
NP435_17940	COG0697	spore germination
NP435_17945	COG1113	amino acid transport
NP435_17950	COG3858	chitin binding
NP435_17955	COG1556	Lactate utilization protein
NP435_17960	COG1139	Iron-sulfur cluster binding protein
NP435_17965	COG0247	lactate metabolic process
NP435_17970	COG2197	response regulator
NP435_17975	COG4585	Histidine kinase
NP435_17980	COG0842	Transport permease protein
NP435_17985	COG1131	(ABC) transporter
NP435_17990	COG0596	Alpha beta hydrolase
NP435_18000	COG3867	Arabinogalactan endo-beta-1,4-galactanase
NP435_18005	COG1874	Beta-galactosidase
NP435_18010	COG3833	ABC-type maltose transport systems, permease component
NP435_18015	COG1175	transmembrane transport
NP435_18020	COG2182	Extracellular solute-binding protein
NP435_18025	COG1609	Transcriptional regulator
NP435_18030	COG2186	Transcriptional regulator
NP435_18035	COG1620	l-lactate permease
NP435_18040	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
NP435_18050	COG5039	Polysaccharide pyruvyl transferase
NP435_18055	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NP435_18060	COG0110	maltose O-acetyltransferase activity
NP435_18065	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
NP435_18070	COG2244	polysaccharide biosynthetic process
NP435_18075	COG1216	Glycosyl transferase, family 2
NP435_18080	COG5039	Polysaccharide pyruvyl transferase
NP435_18085	COG1216	Glycosyl transferase, family 2
NP435_18095	COG0438	transferase activity, transferring glycosyl groups
NP435_18100	COG1215	transferase activity, transferring glycosyl groups
NP435_18105	COG0438	transferase activity, transferring glycosyl groups
NP435_18110	COG1086	Polysaccharide biosynthesis protein
NP435_18115	COG0489	protein tyrosine kinase activity
NP435_18120	COG3944	biosynthesis protein
NP435_18125	COG1396	sequence-specific DNA binding
NP435_18130	COG2272	Belongs to the type-B carboxylesterase lipase family
NP435_18140	COG3479	Phenolic acid decarboxylase
NP435_18155	COG1794	racemase activity, acting on amino acids and derivatives
NP435_18160	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
NP435_18165	COG1621	beta-fructofuranosidase activity
NP435_18170	COG1621	beta-fructofuranosidase activity
NP435_18175	COG0531	amino acid
NP435_18180	COG1309	transcriptional regulator
NP435_18185	COG2076	Multidrug Resistance protein
NP435_18190	COG2076	Multidrug Resistance protein
NP435_18200	COG0277	FAD linked oxidase domain protein
NP435_18205	COG3621	Patatin-like phospholipase
NP435_18215	COG0740	serine-type endopeptidase activity
NP435_18220	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
NP435_18225	COG0366	Alpha amylase catalytic
NP435_18230	COG1554	hydrolase, family 65, central catalytic
NP435_18235	COG5521	maltodextrose utilization protein MalA
NP435_18240	COG3833	ABC-type maltose transport systems, permease component
NP435_18245	COG1175	transmembrane transport
NP435_18250	COG2182	Extracellular solute-binding protein
NP435_18255	COG0366	Alpha amylase catalytic
NP435_18260	COG1609	Transcriptional regulator
NP435_18265	COG1611	Belongs to the LOG family
NP435_18270	COG1694	Mazg nucleotide pyrophosphohydrolase
NP435_18275	COG0659	secondary active sulfate transmembrane transporter activity
NP435_18280	COG0288	reversible hydration of carbon dioxide
NP435_18285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
NP435_18290	COG0577	efflux transmembrane transporter activity
NP435_18295	COG1136	(ABC) transporter
NP435_18300	COG5002	protein histidine kinase activity
NP435_18305	COG0745	RESPONSE REGULATOR receiver
NP435_18315	COG2162	N-hydroxyarylamine O-acetyltransferase activity
NP435_18320	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP435_18325	COG1481	regulation of sporulation
NP435_18330	COG0391	Required for morphogenesis under gluconeogenic growth conditions
NP435_18335	COG1660	Displays ATPase and GTPase activities
NP435_18340	COG1051	belongs to the nudix hydrolase family
NP435_18345	COG0492	ferredoxin-NADP+ reductase activity
NP435_18350	COG3883	PFAM NLP P60 protein
NP435_18350	COG0791	NLP P60 protein
NP435_18355	COG0457	Tetratricopeptide repeat
NP435_18360	COG1132	(ABC) transporter
NP435_18380	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
NP435_18380	COG0140	phosphoribosyl-ATP diphosphatase activity
NP435_18385	COG0107	imidazoleglycerol-phosphate synthase activity
NP435_18390	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
NP435_18395	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
NP435_18400	COG0131	Imidazoleglycerol-phosphate dehydratase
NP435_18405	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
NP435_18410	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
NP435_18415	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
NP435_18420	COG4990	cell redox homeostasis
NP435_18425	COG5297	Belongs to the glycosyl hydrolase family 6
NP435_18430	COG0110	maltose O-acetyltransferase activity
NP435_18435	COG0546	phosphoglycolate phosphatase activity
NP435_18440	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
NP435_18445	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
NP435_18450	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
NP435_18455	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
NP435_18460	COG0363	glucosamine-6-phosphate deaminase activity
NP435_18465	COG2188	Transcriptional regulator
NP435_18470	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NP435_18475	COG1846	Transcriptional regulator
NP435_18480	COG2124	cytochrome p450
NP435_18490	COG1846	Transcriptional regulator
NP435_18495	COG2814	Major facilitator Superfamily
NP435_18500	COG1950	PFAM Membrane protein of
NP435_18505	COG1983	PspC domain protein
NP435_18510	COG3595	metallopeptidase activity
NP435_18530	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
NP435_18535	COG0556	nucleotide-excision repair
NP435_18540	COG4897	Protein conserved in bacteria
NP435_18545	COG0574	Belongs to the PEP-utilizing enzyme family
NP435_18545	COG3848	Pyruvate phosphate dikinase
NP435_18550	COG1309	transcriptional regulator
NP435_18555	COG2814	Major facilitator Superfamily
NP435_18560	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NP435_18570	COG3409	Peptidoglycan-binding domain 1 protein
NP435_18570	COG0793	Belongs to the peptidase S41A family
NP435_18575	COG2177	Part of the ABC transporter FtsEX involved in
NP435_18580	COG2884	Cell division ATP-binding protein ftsE
NP435_18585	COG2010	Cytochrome c
NP435_18590	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP435_18600	COG0653	protein targeting
NP435_18605	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
NP435_18620	COG1516	flagellar protein fliS
NP435_18625	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
NP435_18630	COG1334	flagellar protein FlaG
NP435_18635	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NP435_18640	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
NP435_18645	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
NP435_18655	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
NP435_18660	COG1256	bacterial-type flagellum assembly
NP435_18660	COG4786	Flagellar basal body rod
NP435_18665	COG3418	PFAM FlgN family protein
NP435_18670	COG2747	anti-sigma28 factor FlgM
NP435_18680	COG1040	competence protein
NP435_18690	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
NP435_18695	COG1307	EDD domain protein, DegV family
NP435_18700	COG2197	response regulator
NP435_18705	COG4585	Histidine kinase
NP435_18710	COG1739	Uncharacterized protein family UPF0029
NP435_18715	COG1316	TRANSCRIPTIONal
NP435_18720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
NP435_18725	COG0438	transferase activity, transferring glycosyl groups
NP435_18730	COG1215	transferase activity, transferring glycosyl groups
NP435_18735	COG3206	protein involved in exopolysaccharide biosynthesis
NP435_18740	COG3307	-O-antigen
NP435_18745	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NP435_18750	COG0297	glycogen (starch) synthase activity
NP435_18750	COG0438	transferase activity, transferring glycosyl groups
NP435_18755	COG2244	polysaccharide biosynthetic process
NP435_18765	COG0860	N-Acetylmuramoyl-L-alanine amidase
NP435_18765	COG2247	cell wall binding repeat
NP435_18770	COG2247	cell wall binding repeat
NP435_18770	COG2385	sporulation resulting in formation of a cellular spore
NP435_18780	COG1316	TRANSCRIPTIONal
NP435_18785	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
NP435_18790	COG1210	Utp--glucose-1-phosphate uridylyltransferase
NP435_18800	COG1215	transferase activity, transferring glycosyl groups
NP435_18800	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NP435_18805	COG0463	Glycosyl transferase, family 2
NP435_18825	COG1134	teichoic acid transport
NP435_18830	COG1682	transport, permease protein
NP435_18835	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NP435_18840	COG0438	transferase activity, transferring glycosyl groups
NP435_18845	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
NP435_18850	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
NP435_18855	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NP435_18865	COG4193	domain, Protein
NP435_18870	COG1482	cell wall glycoprotein biosynthetic process
NP435_18875	COG0697	spore germination
NP435_18880	COG0814	amino acid
NP435_18890	COG2814	Major facilitator Superfamily
NP435_18895	COG1316	TRANSCRIPTIONal
NP435_18900	COG0561	phosphatase activity
NP435_18905	COG0791	NLP P60 protein
NP435_18915	COG2843	Capsule synthesis protein
NP435_18925	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
NP435_18930	COG1609	Transcriptional regulator
NP435_18935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP435_18940	COG1869	D-ribose catabolic process
NP435_18945	COG1129	ABC transporter
NP435_18950	COG1172	Belongs to the binding-protein-dependent transport system permease family
NP435_18955	COG1879	ABC-type sugar transport system periplasmic component
NP435_18960	COG3103	Sh3 type 3 domain protein
NP435_18970	COG2249	NAD(P)H dehydrogenase (quinone) activity
NP435_18975	COG3527	Alpha-acetolactate decarboxylase
NP435_18980	COG0028	Belongs to the TPP enzyme family
NP435_18985	COG0583	DNA-binding transcription factor activity
NP435_18990	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
NP435_19005	COG5337	Spore coat protein CotH
NP435_19015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
NP435_19025	COG0405	Gamma-glutamyltransferase
NP435_19030	COG1522	sequence-specific DNA binding
NP435_19035	COG2059	Chromate
NP435_19040	COG2059	Chromate
NP435_19050	COG0655	NAD(P)H dehydrogenase (quinone) activity
NP435_19055	COG0583	DNA-binding transcription factor activity
NP435_19060	COG1515	deoxyribonuclease V activity
NP435_19065	COG2849	repeat protein
NP435_19070	COG5444	nuclease activity
NP435_19090	COG3878	Protein conserved in bacteria
NP435_19095	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
NP435_19100	COG4464	protein tyrosine phosphatase activity
NP435_19105	COG0489	protein tyrosine kinase activity
NP435_19110	COG3944	biosynthesis protein
NP435_19120	COG4715	Zinc finger, swim domain protein
NP435_19125	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
NP435_19130	COG0561	phosphatase activity
NP435_19135	COG1349	DNA-binding transcription factor activity
NP435_19140	COG0629	single-stranded DNA binding
NP435_19160	COG0745	RESPONSE REGULATOR receiver
NP435_19160	COG2972	Histidine kinase
NP435_19165	COG1970	mechanosensitive ion channel activity
NP435_19170	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
NP435_19175	COG0457	Tetratricopeptide repeat
NP435_19180	COG4786	Flagellar basal body rod
NP435_19185	COG4786	Flagellar basal body rod
NP435_19190	COG1077	Cell shape determining protein MreB Mrl
NP435_19195	COG1609	Transcriptional regulator
NP435_19205	COG1846	Transcriptional regulator
NP435_19210	COG2814	Major facilitator Superfamily
NP435_19215	COG3420	alginic acid biosynthetic process
NP435_19220	COG1953	Uracil, thiamine, allantoin
NP435_19225	COG0477	Major facilitator Superfamily
NP435_19230	COG1335	isochorismatase
NP435_19240	COG0004	ammonium transporteR
NP435_19245	COG0347	Belongs to the P(II) protein family
NP435_19250	COG0671	phosphoesterase, PA-phosphatase related
NP435_19260	COG0739	heme binding
NP435_19265	COG1247	-acetyltransferase
NP435_19285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NP435_19290	COG0789	Transcriptional regulator
NP435_19300	COG2910	NAD(P)H-binding
NP435_19305	COG1959	2 iron, 2 sulfur cluster binding
NP435_19310	COG0804	urea catabolic process
NP435_19315	COG0832	Belongs to the urease beta subunit family
NP435_19320	COG0831	urea catabolic process
NP435_19335	COG3237	CsbD-like
NP435_19340	COG1994	Peptidase M50
NP435_19345	COG0457	Tetratricopeptide repeat
NP435_19350	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
NP435_19355	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
NP435_19365	COG2304	oxidoreductase activity
NP435_19375	COG2304	oxidoreductase activity
NP435_19380	COG2385	sporulation resulting in formation of a cellular spore
NP435_19385	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NP435_19395	COG4836	Membrane
NP435_19405	COG0355	proton-transporting ATP synthase activity, rotational mechanism
NP435_19410	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
NP435_19415	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
NP435_19420	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
NP435_19425	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
NP435_19430	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
NP435_19440	COG0356	it plays a direct role in the translocation of protons across the membrane
NP435_19450	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
NP435_19455	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
NP435_19460	COG4475	Protein of unknown function (DUF436)
NP435_19465	COG0698	ribose 5-phosphate isomerase
NP435_19470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
NP435_19475	COG1971	Probably functions as a manganese efflux pump
NP435_19480	COG0009	L-threonylcarbamoyladenylate synthase
NP435_19485	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
NP435_19505	COG2890	protein-(glutamine-N5) methyltransferase activity
NP435_19510	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
NP435_19515	COG0346	lactoylglutathione lyase activity
NP435_19520	COG0789	Transcriptional regulator
NP435_19525	COG0679	Auxin Efflux Carrier
NP435_19530	COG0281	malic enzyme
NP435_19535	COG1435	thymidine kinase activity
NP435_19545	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
NP435_19555	COG1494	fructose-1,6-bisphosphatase
NP435_19560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
NP435_19565	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
NP435_19570	COG0191	fructose-bisphosphate aldolase activity
NP435_19575	COG2204	response regulator
NP435_19580	COG4821	SIS domain
NP435_19585	COG0504	CTP synthase activity
NP435_19590	COG3343	RNA polymerase activity
NP435_19595	COG1960	acyl-CoA dehydrogenase activity
NP435_19600	COG0247	lactate metabolic process
NP435_19600	COG2181	nitrate reductase activity
NP435_19605	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NP435_19610	COG4294	response to UV
NP435_19620	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NP435_19625	COG1132	(ABC) transporter
NP435_19630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
NP435_19640	COG2181	nitrate reductase activity
NP435_19645	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
NP435_19650	COG1140	nitrate reductase beta subunit
NP435_19655	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
NP435_19660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NP435_19670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
NP435_19675	COG2223	nitrite transmembrane transporter activity
NP435_19680	COG0018	arginyl-trna synthetase
NP435_19685	COG4506	Protein conserved in bacteria
NP435_19700	COG0535	radical SAM domain protein
NP435_19710	COG1131	(ABC) transporter
NP435_19715	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
NP435_19720	COG0612	Peptidase, M16
NP435_19725	COG0612	Peptidase, M16
NP435_19735	COG3391	amine dehydrogenase activity
NP435_19740	COG3391	amine dehydrogenase activity
NP435_19745	COG0457	Tetratricopeptide repeat
NP435_19755	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
NP435_19760	COG0010	Belongs to the arginase family
NP435_19765	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
NP435_19770	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
NP435_19780	COG1994	Peptidase M50
NP435_19785	COG1942	4-Oxalocrotonate Tautomerase
NP435_19790	COG1846	Transcriptional regulator
NP435_19795	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
NP435_19800	COG0477	Major facilitator Superfamily
NP435_19805	COG1959	2 iron, 2 sulfur cluster binding
NP435_19810	COG3465	dGTPase activity
NP435_19815	COG1078	dGTPase activity
NP435_19820	COG4844	belongs to the
NP435_19830	COG0697	spore germination
NP435_19835	COG0095	Lipoate-protein ligase
NP435_19840	COG0583	DNA-binding transcription factor activity
NP435_19845	COG0280	phosphate acetyltransferase
NP435_19850	COG3253	May function as heme-dependent peroxidase
NP435_19855	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_19860	COG0436	Aminotransferase
NP435_19865	COG2814	Major facilitator Superfamily
NP435_19870	COG0151	Belongs to the GarS family
NP435_19875	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_19880	COG1917	Cupin 2, conserved barrel domain protein
NP435_19885	COG0077	Prephenate dehydratase
NP435_19890	COG2814	Major facilitator Superfamily
NP435_19895	COG0833	amino acid
NP435_19900	COG4187	Peptidase family M20/M25/M40
NP435_19905	COG1012	belongs to the aldehyde dehydrogenase family
NP435_19910	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
NP435_19920	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
NP435_19925	COG1091	dTDP-4-dehydrorhamnose reductase activity
NP435_19930	COG1088	dTDP-glucose 4,6-dehydratase activity
NP435_19935	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
NP435_19940	COG3980	spore coat polysaccharide biosynthesis protein
NP435_19945	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
NP435_19950	COG2089	acid synthase
NP435_19955	COG0456	acetyltransferase
NP435_19960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
NP435_19965	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
NP435_19970	COG0463	Glycosyl transferase, family 2
NP435_19980	COG2363	Small membrane protein
NP435_19985	COG2233	PERMEase
NP435_19995	COG1012	belongs to the aldehyde dehydrogenase family
NP435_20000	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
NP435_20005	COG1216	Glycosyl transferase, family 2
NP435_20020	COG1695	Transcriptional regulator
NP435_20025	COG0351	phosphomethylpyrimidine kinase
NP435_20035	COG1621	beta-fructofuranosidase activity
NP435_20040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP435_20040	COG1263	PTS System
NP435_20045	COG2116	formate transmembrane transporter activity
NP435_20050	COG3711	transcriptional antiterminator
NP435_20060	COG1404	Belongs to the peptidase S8 family
NP435_20065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP435_20070	COG0778	Nitroreductase
NP435_20075	COG0772	Belongs to the SEDS family
NP435_20085	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
NP435_20090	COG1845	cytochrome c oxidase, subunit III
NP435_20095	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
NP435_20100	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
NP435_20105	COG2261	transglycosylase associated protein
NP435_20110	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
NP435_20115	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
NP435_20120	COG2246	polysaccharide biosynthetic process
NP435_20125	COG1309	transcriptional regulator
NP435_20135	COG3162	membrane
NP435_20140	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
NP435_20145	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
NP435_20150	COG2837	iron assimilation
NP435_20155	COG2822	iron ion transport
NP435_20160	COG0672	)-iron permease
NP435_20165	COG0352	thiamine-phosphate diphosphorylase activity
NP435_20170	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
NP435_20175	COG0583	DNA-binding transcription factor activity
NP435_20180	COG1380	Effector of murein hydrolase LrgA
NP435_20185	COG1346	cytolysis
NP435_20190	COG2814	Major facilitator Superfamily
NP435_20195	COG4895	conserved protein (DUF2196)
NP435_20200	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
NP435_20205	COG0346	lactoylglutathione lyase activity
NP435_20215	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NP435_20220	COG1404	Belongs to the peptidase S8 family
NP435_20225	COG1263	PTS System
NP435_20225	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP435_20230	COG3711	transcriptional antiterminator
NP435_20235	COG1442	glycosyl transferase family 8
NP435_20240	COG5522	Integral membrane protein (intg_mem_TP0381)
NP435_20245	COG1846	Transcriptional regulator
NP435_20250	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
NP435_20255	COG2234	aminopeptidase activity
NP435_20260	COG2357	RelA SpoT domain protein
NP435_20265	COG1575	Belongs to the MenA family. Type 1 subfamily
NP435_20280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
NP435_20285	COG1696	Membrane protein involved in D-alanine export
NP435_20290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
NP435_20295	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
NP435_20300	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
NP435_20305	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
NP435_20310	COG1486	melibiose metabolic process
NP435_20315	COG1447	Phosphotransferase system cellobiose-specific component IIA
NP435_20320	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NP435_20325	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
NP435_20330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
NP435_20330	COG3711	transcriptional antiterminator
NP435_20340	COG2094	Belongs to the DNA glycosylase MPG family
NP435_20345	COG0753	catalase activity
NP435_20350	COG2814	Major facilitator Superfamily
NP435_20355	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
NP435_20360	COG1131	(ABC) transporter
NP435_20380	COG1595	DNA-templated transcription, initiation
NP435_20385	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
NP435_20390	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
NP435_20395	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
NP435_20400	COG4988	ABC transporter
NP435_20405	COG1294	oxidase, subunit
NP435_20410	COG1271	oxidase subunit
NP435_20415	COG3493	citrate carrier protein
NP435_20435	COG0726	polysaccharide deacetylase
NP435_20440	COG3842	ATPase activity
NP435_20445	COG2508	Transcriptional regulator
NP435_20450	COG1012	belongs to the aldehyde dehydrogenase family
NP435_20455	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
NP435_20465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
NP435_20470	COG1881	PFAM PEBP family protein
NP435_20475	COG0583	DNA-binding transcription factor activity
NP435_20485	COG4585	Histidine kinase
NP435_20490	COG2197	response regulator
NP435_20495	COG2195	Cleaves the N-terminal amino acid of tripeptides
NP435_20510	COG4894	glucomannan catabolic process
NP435_20515	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NP435_20520	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
NP435_20525	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_20530	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
NP435_20535	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
NP435_20540	COG2610	gluconate transmembrane transporter activity
NP435_20545	COG0500	methyltransferase
NP435_20550	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NP435_20575	COG0693	protein deglycase activity
NP435_20575	COG0753	catalase activity
NP435_20580	COG2851	Citrate transporter
NP435_20585	COG2273	Hydrolase Family 16
NP435_20590	COG3711	transcriptional antiterminator
NP435_20600	COG2270	Major facilitator Superfamily
NP435_20605	COG0513	Belongs to the DEAD box helicase family
NP435_20610	COG2755	lipolytic protein G-D-S-L family
NP435_20610	COG3401	FG-GAP repeat protein
NP435_20665	COG3209	COG3209 Rhs family protein
NP435_20670	COG0697	spore germination
NP435_20675	COG0589	response to stress
NP435_20680	COG2723	6-phospho-beta-galactosidase activity
NP435_20685	COG1263	PTS System
NP435_20685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP435_20685	COG2190	(PTS) system
NP435_20700	COG5444	nuclease activity
NP435_20715	COG3507	Belongs to the glycosyl hydrolase 43 family
NP435_20730	COG2986	histidine ammonia-lyase
NP435_20735	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
NP435_20740	COG1228	amidohydrolase
NP435_20745	COG0010	Belongs to the arginase family
NP435_20750	COG0833	amino acid
NP435_20755	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
NP435_20760	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
NP435_20765	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
NP435_20770	COG2390	Transcriptional regulator
NP435_20780	COG3192	ethanolamine utilization protein
NP435_20785	COG2079	MmgE PrpD family protein
NP435_20790	COG1473	amidohydrolase
NP435_20795	COG1126	abc transporter atp-binding protein
NP435_20800	COG0765	amino acid transport
NP435_20805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
NP435_20810	COG0456	acetyltransferase
NP435_20815	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
NP435_20825	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
NP435_20830	COG0561	phosphatase activity
NP435_20860	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
NP435_20865	COG5294	Protein conserved in bacteria
NP435_20870	COG0577	efflux transmembrane transporter activity
NP435_20875	COG1136	(ABC) transporter
NP435_20880	COG2205	protein histidine kinase activity
NP435_20885	COG0745	RESPONSE REGULATOR receiver
NP435_20890	COG0191	fructose-bisphosphate aldolase activity
NP435_20895	COG1082	Xylose isomerase domain protein TIM barrel
NP435_20900	COG1082	Xylose isomerase domain protein TIM barrel
NP435_20905	COG0673	inositol 2-dehydrogenase activity
NP435_20910	COG2814	Major facilitator Superfamily
NP435_20915	COG1082	Xylose isomerase domain protein TIM barrel
NP435_20920	COG3962	Belongs to the TPP enzyme family
NP435_20925	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
NP435_20930	COG3718	enzyme involved in inositol metabolism
NP435_20935	COG1012	belongs to the aldehyde dehydrogenase family
NP435_20940	COG1349	DNA-binding transcription factor activity
NP435_20945	COG0667	Aldo Keto reductase
NP435_20960	COG2814	Major facilitator Superfamily
NP435_20965	COG0326	Molecular chaperone. Has ATPase activity
NP435_20975	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_20980	COG1309	transcriptional regulator
NP435_20985	COG1012	belongs to the aldehyde dehydrogenase family
NP435_20990	COG0456	acetyltransferase
NP435_20995	COG2850	peptidyl-arginine hydroxylation
NP435_21000	COG2226	methyltransferase
NP435_21015	COG0367	asparagine synthase
NP435_21020	COG2814	Major facilitator Superfamily
NP435_21025	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
NP435_21035	COG1714	RDD family
NP435_21040	COG2311	Membrane
NP435_21045	COG1917	Cupin 2, conserved barrel domain protein
NP435_21050	COG1309	transcriptional regulator
NP435_21055	COG1028	Short-chain dehydrogenase reductase Sdr
NP435_21060	COG1846	Transcriptional regulator
NP435_21065	COG1380	Effector of murein hydrolase LrgA
NP435_21070	COG1346	cytolysis
NP435_21075	COG5039	Polysaccharide pyruvyl transferase
NP435_21080	COG1929	Belongs to the glycerate kinase type-1 family
NP435_21085	COG1802	Transcriptional regulator
NP435_21090	COG1070	Carbohydrate kinase
NP435_21095	COG2610	gluconate transmembrane transporter activity
NP435_21100	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
NP435_21105	COG0450	alkyl hydroperoxide reductase
NP435_21110	COG3634	alkyl hydroperoxide reductase activity
NP435_21115	COG2723	6-phospho-beta-galactosidase activity
NP435_21125	COG1263	PTS System
NP435_21125	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
NP435_21125	COG2190	(PTS) system
NP435_21130	COG2188	Transcriptional regulator
NP435_21145	COG1131	(ABC) transporter
NP435_21150	COG1994	Peptidase M50
NP435_21155	COG0535	radical SAM domain protein
NP435_21165	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
NP435_21170	COG5293	efflux transmembrane transporter activity
NP435_21180	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
NP435_21185	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
NP435_21200	COG1063	alcohol dehydrogenase
NP435_21220	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
NP435_21225	COG0456	acetyltransferase
NP435_21230	COG0457	Tetratricopeptide repeat
NP435_21240	COG0010	Belongs to the arginase family
NP435_21245	COG0833	amino acid
NP435_21250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
NP435_21255	COG3829	transcription factor binding
NP435_21270	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
NP435_21275	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
NP435_21280	COG4853	Protein conserved in bacteria
NP435_21285	COG4863	YycH protein
NP435_21290	COG5002	protein histidine kinase activity
NP435_21295	COG0745	RESPONSE REGULATOR receiver
NP435_21325	COG0346	lactoylglutathione lyase activity
NP435_21330	COG0305	Participates in initiation and elongation during chromosome replication
NP435_21345	COG3093	addiction module antidote protein HigA
NP435_21350	COG2807	transmembrane transport
NP435_21355	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
NP435_21360	COG0359	binds to the 23S rRNA
NP435_21365	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
NP435_21370	COG4241	membrane
NP435_21380	COG5577	PFAM Coat F domain
NP435_21385	COG1733	regulation of RNA biosynthetic process
NP435_21390	COG1227	inorganic diphosphatase activity
NP435_21405	COG2271	Major facilitator Superfamily
NP435_21445	COG1131	(ABC) transporter
NP435_21460	COG4319	ketosteroid isomerase
NP435_21465	COG1357	PFAM Pentapeptide repeats (8 copies)
NP435_21470	COG2814	Major facilitator Superfamily
NP435_21475	COG0583	DNA-binding transcription factor activity
NP435_21480	COG2153	protein acetylation
NP435_21495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
NP435_21500	COG1846	Transcriptional regulator
NP435_21505	COG2153	protein acetylation
NP435_21510	COG2364	Membrane
NP435_21515	COG0456	acetyltransferase
NP435_21520	COG2315	Protein conserved in bacteria
NP435_21525	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
NP435_21535	COG2814	Major facilitator Superfamily
NP435_21540	COG1331	Highly conserved protein containing a thioredoxin domain
NP435_21545	COG0789	Transcriptional regulator
NP435_21550	COG0697	spore germination
NP435_21555	COG1331	Highly conserved protein containing a thioredoxin domain
NP435_21560	COG1266	CAAX protease self-immunity
NP435_21565	COG0477	Major facilitator Superfamily
NP435_21565	COG2814	Major facilitator Superfamily
NP435_21570	COG0110	maltose O-acetyltransferase activity
NP435_21575	COG0346	lactoylglutathione lyase activity
NP435_21580	COG1609	Transcriptional regulator
NP435_21585	COG0708	Exodeoxyribonuclease III
NP435_21590	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
NP435_21595	COG0629	single-stranded DNA binding
NP435_21600	COG0360	Binds together with S18 to 16S ribosomal RNA
NP435_21605	COG0012	GTP binding
NP435_21610	COG0243	molybdopterin cofactor binding
NP435_21615	COG4481	Protein conserved in bacteria
NP435_21620	COG3949	Membrane
NP435_21630	COG1475	DNA binding
NP435_21635	COG1192	Involved in chromosome partitioning
NP435_21645	COG1475	DNA binding
NP435_21650	COG0357	Ribosomal RNA small subunit methyltransferase G
NP435_21655	COG0445	tRNA wobble uridine modification
NP435_21660	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
NP435_21665	COG1847	R3H domain protein
NP435_21670	COG0706	membrane insertase activity
NP435_21675	COG0594	ribonuclease P activity