locus-tag class description CAH07_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) CAH07_00015 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) CAH07_00030 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) CAH07_00035 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) CAH07_00040 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) CAH07_00055 ENOG4107QJE Chromosome Partitioning Protein CAH07_00060 ENOG4105FA0 parb-like partition protein CAH07_00065 ENOG4108ZDA Sporulation protein YyaC CAH07_00075 ENOG4105VDK protein, conserved in bacteria CAH07_00080 ENOG4108J2R molybdopterin oxidoreductase CAH07_00085 ENOG4105C3G gtp-binding protein CAH07_00090 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) CAH07_00095 ENOG4108UUM single-stranded DNA-binding protein CAH07_00100 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) CAH07_00105 ENOG4105CGK Exodeoxyribonuclease III CAH07_00115 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase CAH07_00120 ENOG4108UW5 maltose o-acetyltransferase CAH07_00130 ENOG4107FCW Abortive infection protein CAH07_00135 ENOG4105C7Z Conserved Protein CAH07_00140 ENOG4108J8C transporter major facilitator family protein CAH07_00150 ENOG4105NAE bifunctional deaminase-reductase domain protein CAH07_00155 ENOG4105UNS Pfam:DUF419 CAH07_00160 ENOG4108U7W acetyltransferase CAH07_00170 ENOG41082BV acetyltransferase CAH07_00175 ENOG4108U05 Transcriptional regulator CAH07_00190 ENOG41082BV acetyltransferase CAH07_00195 ENOG4107RSM transcriptional regulator CAH07_00200 ENOG4105D94 Major Facilitator Superfamily CAH07_00205 ENOG4105DDN Pentapeptide repeat-containing protein CAH07_00210 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein CAH07_00220 ENOG41090E6 transcriptional regulator MERR family CAH07_00235 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase CAH07_00240 ENOG4105KVH Transcriptional regulator CAH07_00255 ENOG4108XMW Membrane CAH07_00260 ENOG4105BZR domain protein CAH07_00265 ENOG4105K9Q Binds to the 23S rRNA (By similarity) CAH07_00270 ENOG4105EDW glycosyl transferase, family 39 CAH07_00275 ENOG4105DJ2 Major Facilitator Superfamily CAH07_00295 ENOG4105CDU Replicative dna helicase CAH07_00300 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase CAH07_00305 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis CAH07_00330 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CAH07_00335 ENOG4105BZU Histidine kinase CAH07_00350 ENOG4105Q2H domain protein CAH07_00355 ENOG4105C0H protease CAH07_00375 ENOG4105BZU Histidine kinase CAH07_00380 ENOG4108JUB Transcriptional regulator CAH07_00385 ENOG4105C8Y Acetylornithine aminotransferase CAH07_00390 ENOG4108IQI permease CAH07_00395 ENOG41066UZ arginase EC 3.5.3.1 CAH07_00405 ENOG410780I phosphoprotein phosphatase activity CAH07_00410 ENOG4105WQG acetyltransferase CAH07_00415 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) CAH07_00435 ENOG4105E2A Dehydrogenase CAH07_00450 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) CAH07_00485 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 CAH07_00495 ENOG4108S3Y transcriptional regulator CAH07_00510 ENOG4105CS2 ec 3.2.1.21 CAH07_00520 ENOG4108JU3 Alkyl hydroperoxide reductase CAH07_00525 ENOG4105D3R alkyl hydroperoxide reductase CAH07_00530 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CAH07_00535 ENOG4105C6Z Gluconate CAH07_00540 ENOG4105CMG Carbohydrate kinase CAH07_00545 ENOG4105G3Z GntR family transcriptional regulator CAH07_00550 ENOG4105BZW Glycerate kinase CAH07_00560 ENOG41067MG lrgb family CAH07_00570 ENOG41061AU MarR family Transcriptional regulator CAH07_00575 ENOG4107JEE Short-chain dehydrogenase reductase Sdr CAH07_00580 ENOG4105J7D transcriptional regulator CAH07_00605 ENOG4108ITS PQQ enzyme repeat CAH07_00610 ENOG4105F22 Major Facilitator Superfamily CAH07_00615 ENOG4105CAQ asparagine synthetase CAH07_00630 ENOG4107Y1Y Methyltransferase CAH07_00635 ENOG4105N1N Cupin superfamily protein CAH07_00640 ENOG4108YM7 Gcn5-related n-acetyltransferase CAH07_00645 ENOG4105C26 Dehydrogenase CAH07_00650 ENOG4105ST3 Transcriptional regulator CAH07_00655 ENOG41061TZ Short-chain dehydrogenase reductase Sdr CAH07_00665 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) CAH07_00670 ENOG4107QNK )-transporter CAH07_00685 ENOG4105CPC Aldo Keto reductase CAH07_00695 ENOG4105C26 Dehydrogenase CAH07_00705 ENOG4105D7K pfkb domain protein CAH07_00710 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) CAH07_00715 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) CAH07_00725 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CAH07_00730 ENOG4105F0H myo-inositol catabolism protein CAH07_00735 ENOG4107TRN Xylose isomerase domain protein TIM barrel CAH07_00740 ENOG4105D2N Aldolase CAH07_00770 ENOG4108V5C ABC transporter CAH07_00800 ENOG410667J hydrolase CAH07_00805 ENOG4107QHE Choloylglycine hydrolase CAH07_00810 ENOG4105CPU Monooxygenase CAH07_00815 ENOG4108XSB acetyltransferase, (GNAT) family CAH07_00820 ENOG4105EAB amino acid AbC transporter CAH07_00825 ENOG4108HW4 amino acid AbC transporter CAH07_00835 ENOG4105CH2 amidohydrolase CAH07_00840 ENOG4108PGP mmge prpd family protein CAH07_00845 ENOG4105ENY Ethanolamine utilization protein eutH CAH07_00850 ENOG4108TM9 integral membrane protein CAH07_00855 ENOG4107RHR regulatoR CAH07_00865 ENOG4105D9N nucleoside CAH07_00870 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) CAH07_00880 ENOG4107W25 arginase agmatinase formiminoglutamase CAH07_00885 ENOG4105CI2 imidazolone-5-propionate hydrolase CAH07_00890 ENOG4105CGP Urocanate hydratase CAH07_00895 ENOG4105C84 Histidine ammonia-lyase CAH07_00910 ENOG4106Z5D Glycoside Hydrolase Family 43 CAH07_00920 ENOG4105M6F mutator MutT protein CAH07_00925 ENOG4108F3G Type I restriction-modification system, R subunit CAH07_00940 ENOG4107EV6 Inherit from COG: YD repeat protein CAH07_00965 ENOG4105C5Y PTS System CAH07_00970 ENOG4105CS2 ec 3.2.1.21 CAH07_00975 ENOG4107YZX Universal stress protein CAH07_00995 ENOG4108Z6Z Transcriptional regulator CAH07_01010 ENOG4105CNA YD repeat protein CAH07_01060 ENOG4107TDE lipolytic protein G-D-S-L family CAH07_01065 ENOG4105C1J atp-dependent rna helicase CAH07_01070 ENOG4105DEU major facilitator superfamily CAH07_01080 ENOG4105CID antiterminator CAH07_01085 ENOG4108RZ2 Glycoside hydrolase family 16 CAH07_01090 ENOG4105D4T Citrate transporter CAH07_01095 ENOG4105CH6 catalase CAH07_01115 ENOG4105DHI Methyltransferase CAH07_01120 ENOG4105CY2 Citrate transporter CAH07_01125 ENOG4105D6N CoA-transferase, subunit a CAH07_01130 ENOG4108IIH CoA-transferase subunit B CAH07_01135 ENOG4105DTD Dehydrogenase CAH07_01160 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CAH07_01165 ENOG4105WH1 Two component transcriptional regulator luxr family CAH07_01170 ENOG4105BZU Histidine kinase CAH07_01180 ENOG4108WAV Transcriptional regulator CAH07_01185 ENOG4105KIS phospholipid-binding protein CAH07_01190 ENOG4105CMR udp-glucose 4-epimerase CAH07_01200 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) CAH07_01220 ENOG4107BJW polysaccharide deacetylase CAH07_01235 ENOG4105D2K citrate carrier protein CAH07_01240 ENOG4105C4M (Ubiquinol oxidase) subunit I CAH07_01245 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CAH07_01250 ENOG4108JJ9 ABC, transporter CAH07_01255 ENOG4108JJ8 (ABC) transporter CAH07_01260 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) CAH07_01265 ENOG4105ETS cytosine purines uracil thiamine allantoin CAH07_01285 ENOG41069JR CAH07_01290 ENOG4105DA5 (ABC) transporter CAH07_01305 ENOG4105CH6 catalase CAH07_01310 ENOG4108VX5 3-methyladenine DNA glycosylase CAH07_01320 ENOG4105EMD TRANSCRIPTIONal CAH07_01325 ENOG4105VZJ PTS System CAH07_01330 ENOG4105CK1 PTS System CAH07_01335 ENOG4105VCP PTS System CAH07_01340 ENOG4105F8D glycoside hydrolase family 4 CAH07_01345 ENOG4105CM2 brancheD-chain amino acid aminotransferase CAH07_01350 ENOG4108VHC Short-chain dehydrogenase reductase Sdr CAH07_01355 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD CAH07_01365 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein CAH07_01370 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) CAH07_01385 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase CAH07_01410 ENOG4105IIU Aminopeptidase CAH07_01415 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CAH07_01420 ENOG4105GVJ transcriptional regulator CAH07_01430 ENOG4105X1N Glycosyl transferase family 8 CAH07_01445 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin CAH07_01450 ENOG4105CK1 PTS System CAH07_01460 ENOG4105DR4 Methyltransferase CAH07_01470 ENOG4105D8G Major Facilitator superfamily CAH07_01475 ENOG41067MG lrgb family CAH07_01480 ENOG4105VAW lrga family CAH07_01485 ENOG4105CMU LysR family (Transcriptional regulator CAH07_01495 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) CAH07_01500 ENOG4107SJW iron permease, FTR1 CAH07_01505 ENOG410650H (LipO)protein CAH07_01510 ENOG4105DBE peroxidase CAH07_01515 ENOG4107ZXU DSBA oxidoreductase CAH07_01540 ENOG4105WH5 Teichoic acid glycosylation protein CAH07_01545 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) CAH07_01555 ENOG4107BMA Transglycosylase associated protein CAH07_01560 ENOG4105E2S oxidase) subunit II CAH07_01565 ENOG4105BZ9 Cytochrome C oxidase, subunit I CAH07_01570 ENOG4105CCU oxidase (Subunit III) CAH07_01575 ENOG41060D1 Quinol oxidase CAH07_01590 ENOG4108DBC nitroreductase CAH07_01595 ENOG4105DEN Luciferase family CAH07_01600 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin CAH07_01615 ENOG4108QTI )-transporter CAH07_01620 ENOG4105C5Y PTS System CAH07_01635 ENOG4105DWF phosphomethylpyrimidine kinase CAH07_01655 ENOG4108RJ9 Glycosyl transferase, family 2 CAH07_01660 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) CAH07_01665 ENOG4105C26 Dehydrogenase CAH07_01705 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CAH07_01710 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD CAH07_01720 ENOG4107TY6 Acylneuraminate cytidylyltransferase CAH07_01725 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG CAH07_01730 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CAH07_01735 ENOG4105C1B dTDP-glucose 4-6-dehydratase CAH07_01740 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase CAH07_01745 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase CAH07_01755 ENOG4105D82 Glutamate dehydrogenase CAH07_01760 ENOG4105C26 Dehydrogenase CAH07_01775 ENOG4105FCW Major Facilitator superfamily CAH07_01780 ENOG41061WN bacilysin biosynthesis protein CAH07_01785 ENOG4106CHD Bacilysin biosynthesis protein bacB CAH07_01790 ENOG4105CHR reductase CAH07_01795 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase CAH07_01805 ENOG4105CHM Aminotransferase CAH07_01820 ENOG4108IJ2 phosphate acetyltransferase CAH07_01825 ENOG4105DUM transcriptional regulator, lysR family CAH07_01830 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) CAH07_01835 ENOG4108RNG Permease of the drug metabolite transporter CAH07_01840 ENOG4108VCI transcription factor, rsfa family CAH07_01850 ENOG4105DCI Phosphohydrolase CAH07_01860 ENOG41062ES Transcriptional regulator CAH07_01865 ENOG4105C57 major facilitator superfamily CAH07_01870 ENOG4105C22 threonyL-tRNA synthetase CAH07_01875 ENOG41067TZ transcriptional regulator, MarR family CAH07_01880 ENOG41069HH 4-oxalocrotonate tautomerase CAH07_01885 ENOG4108Z4T Peptidase M50 CAH07_01890 ENOG4108XFG YwhD family CAH07_01900 ENOG4105BZ4 penicillin-binding protein CAH07_01905 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) CAH07_01910 ENOG4105CYW agmatinase CAH07_01920 ENOG4108RDQ ABC transporter CAH07_01950 ENOG4107JM4 Tetratricopeptide repeat CAH07_02000 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E CAH07_02015 ENOG410684U Domain of unknown function (DUF1934) CAH07_02020 ENOG4105C75 arginyL-tRNA synthetase CAH07_02030 ENOG4107V6Q Cyclic nucleotide-binding domain CAH07_02050 ENOG4108IUE nitrate reductase beta subunit CAH07_02055 ENOG4105R3A Nitrate reductase CAH07_02065 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CAH07_02070 ENOG4105BZ1 (ABC) transporter CAH07_02075 ENOG4105NAE bifunctional deaminase-reductase domain protein CAH07_02085 ENOG4105E5J UV damage endonuclease CAH07_02095 ENOG4105DF6 Fe-S oxidoreductase CAH07_02100 ENOG4105C1G acyl-Coa dehydrogenase CAH07_02110 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) CAH07_02120 ENOG410812K response regulator receiver protein CAH07_02125 ENOG4105D2N Aldolase CAH07_02130 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway CAH07_02135 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CAH07_02140 ENOG4105CBT Fructose-1,6-bisphosphatase CAH07_02145 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CAH07_02150 ENOG41082DI 50s ribosomal protein l31 CAH07_02155 ENOG4107104 thymidine kinase CAH07_02160 ENOG4105C6K Malic enzyme CAH07_02165 ENOG4107TT2 Auxin Efflux Carrier CAH07_02175 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase CAH07_02180 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) CAH07_02185 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CAH07_02200 ENOG4108ZXQ stage ii sporulation protein r CAH07_02210 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CAH07_02215 ENOG410815N Probably functions as a manganese efflux pump (By similarity) CAH07_02220 ENOG4107WAU Protein tyrosine phosphatase CAH07_02225 ENOG4108YZG isomerase CAH07_02230 ENOG4108UIC UPF0340 protein CAH07_02235 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) CAH07_02240 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) CAH07_02250 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) CAH07_02270 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) CAH07_02275 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) CAH07_02280 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) CAH07_02285 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) CAH07_02295 ENOG4106778 Protein of unknown function (DUF1146) CAH07_02305 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) CAH07_02310 ENOG4105JFG SpoIID LytB domain protein CAH07_02325 ENOG4108TF4 von Willebrand factor, type A CAH07_02335 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) CAH07_02375 ENOG4108YZ9 Urea amidohydrolase subunit gamma CAH07_02380 ENOG4105KI2 Urea amidohydrolase subunit beta CAH07_02385 ENOG4105CQM Urea amidohydrolase subunit alpha CAH07_02390 ENOG4108Z40 Transcriptional regulator CAH07_02395 ENOG4108RYK Nad-dependent epimerase dehydratase CAH07_02400 ENOG4106BRK CAH07_02405 ENOG4107TXC Transcriptional regulator CAH07_02410 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CAH07_02425 ENOG4107TCE N-acetyltransferase CAH07_02430 ENOG4105FRN stage II sporulation protein CAH07_02440 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CAH07_02450 ENOG4105BZU Histidine kinase CAH07_02455 ENOG4107P26 CAH07_02460 ENOG4105D3W isochorismatase CAH07_02465 ENOG41080V3 Major Facilitator superfamily CAH07_02470 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease CAH07_02475 ENOG4108M26 parallel beta-helix repeat protein CAH07_02480 ENOG4105CZM Major Facilitator CAH07_02485 ENOG4107MII Sugar-specific transcriptional regulator TrmB CAH07_02495 ENOG4105MT0 Sporulation transcriptional regulator spoiiid CAH07_02500 ENOG4105DFF Rod shape-determining protein mreb CAH07_02510 ENOG4105CGA flagellar basal-body rod protein FlgG CAH07_02520 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) CAH07_02525 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) CAH07_02550 ENOG4105Z8H single-stranded DNA-binding protein CAH07_02555 ENOG4105E98 transcriptional regulator DeoR family CAH07_02560 ENOG410667J hydrolase CAH07_02570 ENOG4105C0D helicase CAH07_02575 ENOG4105KBK Zinc finger, swim domain protein CAH07_02585 ENOG4105HTX biosynthesis protein CAH07_02590 ENOG4107YJ4 chain length determinant protein CAH07_02595 ENOG4108RB3 Capsular polysaccharide biosynthesis protein CAH07_02600 ENOG4105C6Y Udp-glucose 6-dehydrogenase CAH07_02605 ENOG4108XI2 Domain of unknown function (DUF1963) CAH07_02635 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) CAH07_02640 ENOG4107V2S Transcriptional regulator CAH07_02645 ENOG4108WS4 fmn reductase CAH07_02655 ENOG4105FGV Chromate CAH07_02660 ENOG4105CAH Chromate CAH07_02670 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) CAH07_02680 ENOG4107XC4 flavin reductase domain protein, FMN-binding CAH07_02695 ENOG4106UIA CAH07_02710 ENOG4107RSM transcriptional regulator CAH07_02720 ENOG4107FQX Alpha-acetolactate decarboxylase CAH07_02725 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CAH07_02740 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator CAH07_02745 ENOG4105CNN ABC, transporter CAH07_02750 ENOG4105C2J ABC transporter CAH07_02755 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) CAH07_02760 ENOG4108RVA ribokinase CAH07_02765 ENOG4105ETE Transcriptional regulator (LacI family CAH07_02775 ENOG4105N98 Capsule biosynthesis protein capB CAH07_02785 ENOG4105PNM synthesis protein CAH07_02795 ENOG4105K4H Nlp p60 protein CAH07_02800 ENOG4105J7I hydrolase CAH07_02805 ENOG4108KGH TRANSCRIPTIONal CAH07_02810 ENOG4105C54 Major Facilitator superfamily CAH07_02815 ENOG4108NHD germination protein CAH07_02830 ENOG4105DG6 mannose-6-phosphate isomerase CAH07_02880 ENOG41088M2 Glycosyl transferase family 2 CAH07_02905 ENOG4105EY8 ABC transporter CAH07_02910 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CAH07_02930 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase CAH07_02945 ENOG4105JFG SpoIID LytB domain protein CAH07_02950 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CAH07_02960 ENOG4105D3Q Sugar transferase CAH07_02965 ENOG4105PSV Polysaccharide Biosynthesis Protein CAH07_02970 ENOG4107RA4 Glycosyl transferase (Group 1 CAH07_02975 ENOG4105C6Y Udp-glucose 6-dehydrogenase CAH07_02980 ENOG4105QZI O-Antigen Polymerase CAH07_02995 ENOG4107EF8 Glycosyl transferase (Group 1 CAH07_03000 ENOG4105ESV Glycosyl transferase, family 4 CAH07_03005 ENOG4108KGH TRANSCRIPTIONal CAH07_03010 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CAH07_03015 ENOG4105BZU Histidine kinase CAH07_03020 ENOG4105WH1 Two component transcriptional regulator luxr family CAH07_03040 ENOG41081UC Inherit from COG: Competence protein CAH07_03045 ENOG4105RU3 CAH07_03060 ENOG4105E1Q flagellar hook-associated protein CAH07_03065 ENOG4105DTJ flagellar hook-associated protein CAH07_03070 ENOG4105MKD CAH07_03075 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) CAH07_03080 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) CAH07_03085 ENOG4105I03 Flagellin CAH07_03090 ENOG41083S7 flagellar protein FlaG CAH07_03095 ENOG4107RT6 flagellar hook-associated CAH07_03100 ENOG4105MQ3 flagellar protein FliS CAH07_03115 ENOG4105MS2 ribosomal subunit Interface protein CAH07_03125 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) CAH07_03130 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) CAH07_03145 ENOG4105CAK Cell division ATP-binding protein ftsE CAH07_03150 ENOG4105CRP Part of the ABC transporter FtsEX involved in CAH07_03155 ENOG4105CN1 protease CAH07_03175 ENOG4105MKU Transcriptional regulator CAH07_03190 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) CAH07_03195 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CAH07_03200 ENOG4105I03 Flagellin CAH07_03215 ENOG4108PY7 CAH07_03220 ENOG41067S9 phage shock protein C, PspC CAH07_03225 ENOG41086DT Membrane protein of unknown function CAH07_03240 ENOG410625E CAH07_03245 ENOG4106A3M Cytochrome p-450 CAH07_03255 ENOG41088CQ domain protein CAH07_03260 ENOG4105FDP GntR family transcriptional regulator CAH07_03265 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) CAH07_03270 ENOG4105CE4 GlcNAc 6-P deacetylase CAH07_03275 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) CAH07_03280 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) CAH07_03285 ENOG4105HKU nucleoside recognition domain-containing protein CAH07_03290 ENOG4107XGZ Hydrolase CAH07_03295 ENOG4108S4C acetyltransferase CAH07_03300 ENOG4108E16 pectate lyase CAH07_03310 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) CAH07_03315 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) CAH07_03320 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) CAH07_03325 ENOG4105ECC imidazole-glycerol-phosphate dehydratase CAH07_03330 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) CAH07_03335 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase CAH07_03340 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) CAH07_03345 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase CAH07_03360 ENOG4106FGC CAH07_03370 ENOG4105BZ1 (ABC) transporter CAH07_03385 ENOG4105C3M thioredoxin reductase CAH07_03390 ENOG4108Z4K mutator MutT protein CAH07_03395 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) CAH07_03400 ENOG4105CHW UPF0052 protein CAH07_03405 ENOG4105CIE May be required for sporulation (By similarity) CAH07_03410 ENOG4105KRI phosphocarrier protein (HPr CAH07_03415 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase CAH07_03420 ENOG4107A6P CAH07_03430 ENOG4105EWM Histidine kinase CAH07_03435 ENOG4105C19 ABC transporter CAH07_03445 ENOG4105C5I Dehydrogenase CAH07_03450 ENOG4108V2W Carbonate dehydratase CAH07_03455 ENOG4105CHH sulfate transporter CAH07_03460 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain CAH07_03465 ENOG4108URH decarboxylase CAH07_03470 ENOG4105FKQ transcriptional regulator CAH07_03475 ENOG4108IUK alpha amylase, catalytic CAH07_03480 ENOG4107FKK extracellular solute-binding protein family 1 CAH07_03485 ENOG4105D56 permease protein CAH07_03490 ENOG4105EG2 ABC transporter, permease CAH07_03505 ENOG4105CG3 alpha amylase, catalytic region CAH07_03510 ENOG4107URF beta-phospho-glucomutase CAH07_03515 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) CAH07_03525 ENOG4105IRW patatin-like phospholipase family protein CAH07_03530 ENOG4105DNP FAD linked oxidase domain protein CAH07_03555 ENOG4107QTZ amino acid CAH07_03560 ENOG4108HKT sucrose-6-phosphate hydrolase CAH07_03565 ENOG4105EDQ levansucrase EC 2.4.1.10 CAH07_03570 ENOG4105FQP Beta-lactamase CAH07_03580 ENOG4105NI3 Protein of unknown function (DUF3237) CAH07_03585 ENOG4105PY6 Phenolic acid decarboxylase CAH07_03595 ENOG4105EBR Carboxylesterase CAH07_03605 ENOG4105HTX biosynthesis protein CAH07_03610 ENOG4108QV3 biosynthesis protein CAH07_03620 ENOG4108PQP glycosyl transferase group 1 CAH07_03625 ENOG4105K64 Glycosyl transferase, family 2 CAH07_03630 ENOG4108KMV Glycosyl transferase (Group 1 CAH07_03635 ENOG41068W6 Capsular polysaccharide biosynthesis protein CAH07_03640 ENOG4107QRS glycosyltransferase group 2 family protein CAH07_03650 ENOG4105K64 Glycosyl transferase, family 2 CAH07_03660 ENOG4105D3Q Sugar transferase CAH07_03665 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family CAH07_03670 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase CAH07_03675 ENOG4108ZPC Polysaccharide pyruvyl transferase CAH07_03685 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CAH07_03690 ENOG4105DAA L-lactate CAH07_03695 ENOG4105JXH GntR family transcriptional regulator CAH07_03705 ENOG4107FKK extracellular solute-binding protein family 1 CAH07_03715 ENOG4105EG2 ABC transporter, permease CAH07_03730 ENOG4108MJI response regulator CAH07_03735 ENOG4107R6F Alpha Beta Hydrolase Fold protein CAH07_03740 ENOG4108M15 ABC transporter CAH07_03745 ENOG4105KCT ABC transporter CAH07_03750 ENOG4105BZU Histidine kinase CAH07_03760 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CAH07_03765 ENOG4107QR9 Iron-sulfur cluster binding protein CAH07_03770 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) CAH07_03775 ENOG4105VRS hydrolase family 18 CAH07_03785 ENOG4107RT3 EamA-like transporter family CAH07_03790 ENOG4105GZI Transcriptional regulator CAH07_03800 ENOG4105DEN Luciferase family CAH07_03805 ENOG4105CMD Transcriptional regulator, GntR family CAH07_03820 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CAH07_03825 ENOG4105BZA Phosphoglycerate kinase CAH07_03830 ENOG4105CP7 Triose-phosphate isomerase CAH07_03835 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) CAH07_03840 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) CAH07_03845 ENOG4108W0I acetyltransferase CAH07_03850 ENOG4105T65 Membrane-associated protein CAH07_03860 ENOG4108QCI YvbH-like oligomerisation region CAH07_03865 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein CAH07_03870 ENOG4107HG4 Transcriptional regulator CAH07_03875 ENOG4108IJ8 ABC transporter CAH07_03880 ENOG4105E90 ABC transporter CAH07_03885 ENOG4108HQR Glycine betaine CAH07_03890 ENOG4105R40 Glycine betaine carnitine choline CAH07_03895 ENOG4107HG4 Transcriptional regulator CAH07_03900 ENOG4108IJ8 ABC transporter CAH07_03905 ENOG4105E90 ABC transporter CAH07_03910 ENOG4108HQR Glycine betaine CAH07_03915 ENOG4105R40 Glycine betaine carnitine choline CAH07_03920 ENOG4105C8Q Methyl-accepting chemotaxis CAH07_03925 ENOG4105KVH Transcriptional regulator CAH07_03950 ENOG4105XZU Preprotein translocase, subunit SecG CAH07_03960 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CAH07_03965 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) CAH07_03975 ENOG4105EWI Short-chain dehydrogenase reductase Sdr CAH07_03980 ENOG4105KBX Transcriptional regulator, TetR family CAH07_03985 ENOG4105KPY Small multidrug resistance protein CAH07_03990 ENOG4105RXJ CAH07_03995 ENOG4105ME7 Membrane CAH07_04000 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CAH07_04005 ENOG4105D9R oxidoreductase CAH07_04010 ENOG4105VPX protein, conserved in bacteria CAH07_04015 ENOG410681U heavy metal transport detoxification protein CAH07_04020 ENOG4105C59 p-type ATPase CAH07_04025 ENOG4105C59 p-type ATPase CAH07_04030 ENOG4107ZQN disulfide bond CAH07_04040 ENOG4105EN6 Membrane CAH07_04045 ENOG4105EEM helicase CAH07_04050 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CAH07_04055 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CAH07_04060 ENOG4105EEQ Na H antiporter CAH07_04075 ENOG4105E0C molybdate abc transporter CAH07_04080 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein CAH07_04085 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family CAH07_04090 ENOG4107QZ2 Sulfatase CAH07_04095 ENOG4107K5X Membrane-bound metal-dependent hydrolase CAH07_04110 ENOG4105D5Q Arginine ornithine antiporter CAH07_04125 ENOG4105DQ5 transport system permease protein CAH07_04130 ENOG4105EHG Permease protein CAH07_04135 ENOG4105E0A ABC, transporter CAH07_04140 ENOG4108WMK Efflux transporter RND family MFP subunit CAH07_04145 ENOG4105C19 ABC transporter CAH07_04150 ENOG4107RBB ABC transporter, permease CAH07_04160 ENOG4105F0F Oxalate decarboxylase CAH07_04170 ENOG4106DF4 Sigma-70, region 4 CAH07_04180 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CAH07_04190 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein CAH07_04195 ENOG4105EWI Short-chain dehydrogenase reductase Sdr CAH07_04200 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) CAH07_04205 ENOG4105EHG Permease protein CAH07_04210 ENOG4105E0A ABC, transporter CAH07_04215 ENOG4108WBT adenosyltransferase CAH07_04230 ENOG41087YS Phage shock protein A CAH07_04245 ENOG4105ENE Histidine kinase CAH07_04250 ENOG4105WH1 Two component transcriptional regulator luxr family CAH07_04275 ENOG4105C9Q fumarate hydratase class II CAH07_04280 ENOG41067SE Tetr family transcriptional regulator CAH07_04290 ENOG4105F3H Histidine kinase CAH07_04300 ENOG4105C0H protease CAH07_04305 ENOG4105HUF DNA protection during starvation protein CAH07_04310 ENOG4105E1F short-chain dehydrogenase reductase CAH07_04325 ENOG4105E0A ABC, transporter CAH07_04335 ENOG4105EGI Transcriptional regulator CAH07_04345 ENOG4105MDS 4-oxalocrotonate tautomerase CAH07_04350 ENOG4105C0R drug resistance transporter emrb qaca subfamily CAH07_04355 ENOG41067TZ transcriptional regulator, MarR family CAH07_04385 ENOG4105CHU acetyl-coa acetyltransferase CAH07_04390 ENOG4105C1G acyl-Coa dehydrogenase CAH07_04395 ENOG41080E8 Transcriptional regulator, Spx MgsR family CAH07_04400 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) CAH07_04425 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CAH07_04430 ENOG4108UMI ABC transporter, permease CAH07_04435 ENOG4105D01 (LipO)protein CAH07_04455 ENOG4105C3K feS assembly ATPase SufC CAH07_04460 ENOG4105JRK feS assembly protein SufD CAH07_04465 ENOG4105C9B Cysteine desulfurase CAH07_04470 ENOG4108UNV SUF system FeS assembly protein, NifU family CAH07_04475 ENOG4105DIW FeS assembly protein SUFB CAH07_04480 ENOG4105NPE arsR family transcriptional regulator CAH07_04485 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase CAH07_04500 ENOG4107VFR oxidoreductase CAH07_04505 ENOG4105PKS Excinuclease abc c subunit domain protein CAH07_04510 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine CAH07_04515 ENOG4105XN3 extracellular solute-binding protein family 1 CAH07_04520 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component CAH07_04525 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component CAH07_04530 ENOG4108KPW sugar kinase CAH07_04535 ENOG4105FDP GntR family transcriptional regulator CAH07_04540 ENOG4108IJ9 (ABC) transporter CAH07_04545 ENOG4108K8S endonuclease I CAH07_04555 ENOG4105C5R Aminotransferase CAH07_04560 ENOG4105XRQ Xanthine dehydrogenase accessory factor CAH07_04575 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding CAH07_04580 ENOG4107YV9 domain protein CAH07_04590 ENOG4105VT2 5-hydroxyisourate hydrolase CAH07_04595 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) CAH07_04610 ENOG4105G9B Transcriptional regulator CAH07_04615 ENOG4105CD3 dihydroorotase CAH07_04625 ENOG4105I3N Conserved Protein CAH07_04635 ENOG4107R8B 5'-nucleotidase CAH07_04640 ENOG4105KZD Domain of unknown function (DUF1805) CAH07_04645 ENOG4108YTE sporulation protein YunB CAH07_04650 ENOG4105FAA peptidase M23 CAH07_04655 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) CAH07_04660 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) CAH07_04665 ENOG4105MMD transcriptional regulator CAH07_04675 ENOG4105D4U had-superfamily hydrolase, subfamily iia CAH07_04680 ENOG4108W5N phosphatidylglycerophosphatase a CAH07_04690 ENOG4105D6E homoserine dehydrogenase CAH07_04695 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) CAH07_04700 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) CAH07_04705 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein CAH07_04710 ENOG41083MR nifu domain-containing protein CAH07_04725 ENOG4105ZKE UPF0349 protein CAH07_04740 ENOG4108YX9 iron--sulfur cluster insertion protein erpA CAH07_04745 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 CAH07_04765 ENOG4105CAY ferredoxin--nadp reductase CAH07_04770 ENOG4105CEP NADH dehydrogenase CAH07_04785 ENOG41069ER domain protein CAH07_04795 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) CAH07_04815 ENOG4105NIV Esterase CAH07_04820 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase CAH07_04825 ENOG4105E4F Isochorismate synthase CAH07_04830 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase CAH07_04835 ENOG4105WQI isochorismatase CAH07_04840 ENOG4105CEY Amp-dependent synthetase and ligase CAH07_04845 ENOG4105WQT MbtH domain protein CAH07_04855 ENOG4105DCF alanine dehydrogenase CAH07_04860 ENOG4108K8K Transcriptional regulator CAH07_04900 ENOG410904N short-chain dehydrogenase reductase CAH07_04920 ENOG4105C02 permease CAH07_04945 ENOG4105DAP Nicotinate phosphoribosyltransferase CAH07_04950 ENOG4105D58 Diguanylate phosphodiesterase CAH07_04975 ENOG4105BZU Histidine kinase CAH07_04985 ENOG4105KA0 thioesterase Superfamily protein CAH07_04990 ENOG4105KJM monovalent cation h antiporter subunit g CAH07_05000 ENOG4105SC1 monovalent cation H antiporter subunit E CAH07_05005 ENOG4108JPZ Monovalent cation H antiporter subunit D CAH07_05010 ENOG4108ZE9 Monovalent cation H antiporter subunit C CAH07_05015 ENOG4105HC0 Na H antiporter CAH07_05020 ENOG4105D65 subunit l CAH07_05040 ENOG4105UIB (ABC) transporter CAH07_05045 ENOG4108JQ9 ABC transporter CAH07_05050 ENOG4105DIH basic membrane CAH07_05055 ENOG4108MRH transcriptional regulatory protein CAH07_05070 ENOG4105KIR Thiol-disulfide oxidoreductase dcc CAH07_05075 ENOG4105BZ4 penicillin-binding protein CAH07_05095 ENOG4105Y38 Kinase-associated protein B CAH07_05100 ENOG4108HGU Histidine kinase CAH07_05105 ENOG4105C87 Aminotransferase class I and II CAH07_05115 ENOG4108MUZ hydrolase CAH07_05120 ENOG4108ZB6 transcriptional regulator AsnC family CAH07_05125 ENOG4105CHM Aminotransferase CAH07_05135 ENOG4105WG9 Conserved Protein CAH07_05140 ENOG4107QW4 alcohol dehydrogenase CAH07_05150 ENOG4107QYV phosphohexose isomerase CAH07_05165 ENOG4107PBV potassium channel CAH07_05170 ENOG4107PBV potassium channel CAH07_05185 ENOG4105C37 (CBS) domain CAH07_05195 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme CAH07_05210 ENOG4105C8Q Methyl-accepting chemotaxis CAH07_05215 ENOG4105C8Q Methyl-accepting chemotaxis CAH07_05220 ENOG4105C8Q Methyl-accepting chemotaxis CAH07_05225 ENOG4105C8Q Methyl-accepting chemotaxis CAH07_05240 ENOG4105E98 transcriptional regulator DeoR family CAH07_05245 ENOG4105DET Rhamnulokinase CAH07_05250 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) CAH07_05255 ENOG4105DKG l-rhamnose isomerase CAH07_05260 ENOG4105EE0 oxidoreductase CAH07_05270 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) CAH07_05290 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj CAH07_05295 ENOG4107I77 yiaA/B two helix domain CAH07_05300 ENOG4105CZN Potassium uptake protein CAH07_05315 ENOG4105TRT Transcriptional regulator CAH07_05320 ENOG4105C26 Dehydrogenase CAH07_05325 ENOG4108JB8 alcohol dehydrogenase CAH07_05330 ENOG4108VNY MOSC domain protein CAH07_05335 ENOG4106DF1 CAH07_05345 ENOG4105DZ6 Band 7 protein CAH07_05350 ENOG4105VRR gCN5-related N-acetyltransferase CAH07_05355 ENOG4105N67 Proton-coupled thiamine transporter YuaJ CAH07_05485 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) CAH07_05495 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) CAH07_05510 ENOG4108KS4 Spore coat protein CAH07_05515 ENOG4107SBE Glycosyl transferase (Group 1 CAH07_05530 ENOG4107SBE Glycosyl transferase (Group 1 CAH07_05535 ENOG4108IAJ Nad-dependent epimerase dehydratase CAH07_05555 ENOG4105E4F Isochorismate synthase CAH07_05560 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) CAH07_05565 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) CAH07_05570 ENOG4108IPT Naphthoate synthase CAH07_05575 ENOG4105CEY Amp-dependent synthetase and ligase CAH07_05580 ENOG4105DTQ mandelate racemase muconate lactonizing CAH07_05585 ENOG4105DSE periplasmic solute binding protein CAH07_05590 ENOG4105DIK (ABC) transporter CAH07_05595 ENOG4105CC5 ABC transporter CAH07_05600 ENOG4105CC5 ABC transporter CAH07_05625 ENOG4108V2W Carbonate dehydratase CAH07_05630 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) CAH07_05635 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) CAH07_05650 ENOG4108RMU ferritin dps family protein CAH07_05665 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component CAH07_05675 ENOG4105D2X ABC transporter substrate-binding protein CAH07_05690 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase CAH07_05695 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP CAH07_05700 ENOG4105CAQ asparagine synthetase CAH07_05705 ENOG4105C85 amino acid CAH07_05710 ENOG4108Z0R Transferase CAH07_05715 ENOG4105E8V Alpha Beta Hydrolase Fold protein CAH07_05730 ENOG4105N5T Radical SAM Protein CAH07_05740 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family CAH07_05745 ENOG4105DVE abc transporter atp-binding protein CAH07_05760 ENOG4105C19 ABC transporter CAH07_05765 ENOG4107R34 abc transporter permease protein CAH07_05775 ENOG4105EWM Histidine kinase CAH07_05780 ENOG4105C19 ABC transporter CAH07_05790 ENOG4106UBQ CAH07_05795 ENOG410605W Major Facilitator CAH07_05800 ENOG4105BZU Histidine kinase CAH07_05810 ENOG4105C8T Leucyl-tRNA synthetase CAH07_05815 ENOG41085GJ domain protein CAH07_05825 ENOG4105I1K ABC transporter CAH07_05830 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component CAH07_05845 ENOG4105NTD Inherit from COG: Hydrolase CAH07_05855 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CAH07_05860 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CAH07_05870 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) CAH07_05875 ENOG4106A3M Cytochrome p-450 CAH07_05885 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component CAH07_05895 ENOG41075H3 AraC family transcriptional regulator CAH07_05905 ENOG4105F5H Glycosyl Hydrolase Family 88 CAH07_05915 ENOG4105DDC Oxidoreductase domain protein CAH07_05920 ENOG4105MU9 integral membrane protein CAH07_05930 ENOG4105C94 Transporter CAH07_05935 ENOG4105CBX hi0933 family CAH07_05950 ENOG4105YW5 deoR family transcriptional regulator CAH07_05965 ENOG4105C7N Xanthine uracil vitamin C permease CAH07_05970 ENOG4107QSE Dipeptidase CAH07_05975 ENOG4105C6T cysteine synthase CAH07_05980 ENOG4107F58 2'-5' rna ligase CAH07_05995 ENOG4108IUM Glycogen debranching enzyme CAH07_06000 ENOG4108V15 phosphotransferase enzyme family CAH07_06010 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) CAH07_06015 ENOG4105C8F Beta-lactamase domain protein CAH07_06020 ENOG4105C6K Malic enzyme CAH07_06035 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ CAH07_06050 ENOG4108VDD TRNA binding domain protein CAH07_06060 ENOG4105DFU Cell wall formation (By similarity) CAH07_06080 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase CAH07_06085 ENOG4105ETE Transcriptional regulator (LacI family CAH07_06090 ENOG4107R0U MotA TolQ exbB proton channel CAH07_06095 ENOG4105ER2 Ompa motb domain protein CAH07_06100 ENOG4105DGU Histone deacetylase CAH07_06105 ENOG4105W87 Cbs domain CAH07_06110 ENOG4105F1V Acetoin utilization protein CAH07_06125 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) CAH07_06130 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) CAH07_06140 ENOG4105BZU Histidine kinase CAH07_06150 ENOG4105U5Y Transcriptional regulator CAH07_06185 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) CAH07_06190 ENOG4105EFZ amidohydrolase CAH07_06195 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CAH07_06200 ENOG4105D07 Signal peptide peptidase, SppA CAH07_06205 ENOG4105VK3 rdd domain containing protein CAH07_06215 ENOG4105KBJ sporulation protein ytfj CAH07_06220 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CAH07_06235 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) CAH07_06240 ENOG4105EPU Molybdenum cofactor synthesis domain protein CAH07_06245 ENOG4105CDH Citrulline--aspartate ligase CAH07_06250 ENOG4105CH7 arginosuccinase CAH07_06265 ENOG4105E8R UPF0173 metal-dependent hydrolase CAH07_06270 ENOG4108KSA LysR family transcriptional regulator CAH07_06275 ENOG4108XSB acetyltransferase, (GNAT) family CAH07_06300 ENOG4105CDA abc transporter atp-binding protein CAH07_06305 ENOG4105DEN Luciferase family CAH07_06325 ENOG4105CH2 amidohydrolase CAH07_06330 ENOG410635A Membrane CAH07_06345 ENOG4105SFS phosphoesterase RecJ domain protein CAH07_06350 ENOG4106EVM CAH07_06360 ENOG4105VV2 CAH07_06365 ENOG4105C0B DNA polymerase III (alpha subunit) CAH07_06370 ENOG4105C6K Malic enzyme CAH07_06375 ENOG4108IEY Carboxyl transferase domain CAH07_06385 ENOG4105CTQ phosphohexokinase CAH07_06390 ENOG4105CA9 Pyruvate kinase CAH07_06395 ENOG4105FS0 cytoplasmic membrane protein CAH07_06400 ENOG4108REF Sporulation integral membrane protein ytvi CAH07_06410 ENOG4105BZN citrate synthase CAH07_06415 ENOG4108HMX isocitrate dehydrogenase (NADP) CAH07_06420 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CAH07_06425 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CAH07_06430 ENOG4105BZU Histidine kinase CAH07_06435 ENOG4105C2M dna polymerase I CAH07_06440 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CAH07_06450 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CAH07_06455 ENOG4105CV8 reductase CAH07_06460 ENOG4105F27 Major Facilitator CAH07_06465 ENOG4105KVH Transcriptional regulator CAH07_06470 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CAH07_06475 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) CAH07_06480 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) CAH07_06500 ENOG4108TDW sporulation protein YtxC CAH07_06505 ENOG4105C22 threonyL-tRNA synthetase CAH07_06510 ENOG4105U0R haloacid dehalogenase-like hydrolase CAH07_06515 ENOG4108HRK Histidine kinase CAH07_06520 ENOG4105DY9 regulatoR CAH07_06530 ENOG41067MG lrgb family CAH07_06540 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) CAH07_06545 ENOG4105VJV 50s ribosomal protein L35 CAH07_06550 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) CAH07_06555 ENOG410696E Membrane CAH07_06565 ENOG4105CN9 Peptidase m42 family protein CAH07_06570 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase CAH07_06580 ENOG4105EF1 ribulokinase CAH07_06585 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase CAH07_06595 ENOG4108MDK Dehydrogenase CAH07_06610 ENOG4105DRS transport system, permease CAH07_06615 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) CAH07_06635 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CAH07_06640 ENOG4105CQB FAD linked oxidase domain protein CAH07_06650 ENOG41067MF small acid-soluble spore protein CAH07_06655 ENOG4108RWN rrna methyltransferase CAH07_06665 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) CAH07_06670 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) CAH07_06675 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CAH07_06690 ENOG4105DCG PHP domain protein CAH07_06695 ENOG4105C98 muts2 protein CAH07_06705 ENOG4105CEY Amp-dependent synthetase and ligase CAH07_06710 ENOG4107Z3H Transcriptional regulator, TetR family CAH07_06715 ENOG41060WC Enoyl-CoA hydratase CAH07_06720 ENOG4105BZJ Electron transfer flavoprotein CAH07_06725 ENOG4105C10 Electron transfer flavoprotein CAH07_06730 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) CAH07_06740 ENOG4105K63 Thioredoxin CAH07_06745 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CAH07_06755 ENOG4105CFH Aspartokinase CAH07_06765 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit CAH07_06775 ENOG4105E33 succinate dehydrogenase CAH07_06785 ENOG4105PFC Transcriptional regulator CAH07_06790 ENOG41067TZ transcriptional regulator, MarR family CAH07_06795 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) CAH07_06800 ENOG4108XJQ germination protein CAH07_06805 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) CAH07_06810 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) CAH07_06815 ENOG4105M59 Phosphodiesterase, mj0936 family CAH07_06825 ENOG4107KM7 Heat induced stress protein YflT CAH07_06840 ENOG4105I4A GCN5-related N-acetyltransferase CAH07_06855 ENOG4105C7K acetolactate synthase CAH07_06860 ENOG4108ZP8 Acetolactate synthase small subunit CAH07_06865 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase CAH07_06870 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) CAH07_06875 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CAH07_06880 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CAH07_06885 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) CAH07_06895 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CAH07_06900 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) CAH07_06905 ENOG4108IUQ atp-dependent protease CAH07_06910 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) CAH07_06915 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) CAH07_06925 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) CAH07_06935 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) CAH07_06945 ENOG4105D52 delta-aminolevulinic acid dehydratase CAH07_06950 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase CAH07_06955 ENOG41068KH stage VI sporulation protein D CAH07_06960 ENOG4106AR7 Spore coat protein CAH07_06970 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) CAH07_06975 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CAH07_06980 ENOG4106A3R peptidase CAH07_06990 ENOG4108Z03 MAF-like protein CAH07_06995 ENOG4105W5Q DNA repair protein (RadC CAH07_07000 ENOG4105DFF Rod shape-determining protein mreb CAH07_07005 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) CAH07_07010 ENOG4105YHC Rod shape-determining protein MreD CAH07_07015 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) CAH07_07020 ENOG4107QMS site-determining protein CAH07_07035 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) CAH07_07040 ENOG4105X36 (ribosomal) protein CAH07_07045 ENOG4105K46 50S ribosomal protein l27 CAH07_07055 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control CAH07_07060 ENOG41090I5 UPF0735 ACT domain-containing protein CAH07_07065 ENOG4105CQC Prephenate dehydratase CAH07_07080 ENOG4108IYU L-aspartate oxidase CAH07_07085 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase CAH07_07090 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) CAH07_07095 ENOG4106678 morphogenetic protein associated with SpoVID CAH07_07105 ENOG4105CDY transcriptional regulatory protein CAH07_07110 ENOG4105BZG amino acid carrier protein CAH07_07130 ENOG4105CK5 oxidoreductase CAH07_07135 ENOG4105IE8 Alpha-ketoglutarate permease CAH07_07145 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) CAH07_07150 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) CAH07_07155 ENOG41061AI Protein of unknown function (DUF2905) CAH07_07160 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) CAH07_07165 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) CAH07_07170 ENOG4105VIE preprotein translocase, subunit YajC CAH07_07175 ENOG4105NAP CAH07_07180 ENOG4108QG2 Membrane CAH07_07185 ENOG4105CKP Polysaccharide Biosynthesis Protein CAH07_07195 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CAH07_07200 ENOG4105NCW Trka-c domain protein CAH07_07205 ENOG41067VP Protein of unknown function (DUF1049) CAH07_07210 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) CAH07_07215 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) CAH07_07220 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CAH07_07230 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CAH07_07240 ENOG4105CUT histidyl-tRNA synthetase CAH07_07245 ENOG4105C9M aspartyl-trna synthetase CAH07_07255 ENOG4105CUZ uba thif-type nad fad binding protein CAH07_07260 ENOG4105D1H recombination factor protein RarA CAH07_07270 ENOG4105C3J Cysteine desulfurase CAH07_07275 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) CAH07_07285 ENOG4105C7H Helicase, RecD TraA family CAH07_07295 ENOG41060CR CAH07_07305 ENOG4105DRP amino acid AbC transporter CAH07_07310 ENOG4105EAD ABC transporter CAH07_07315 ENOG4105CT1 (ABC) transporter CAH07_07320 ENOG4105CDA abc transporter atp-binding protein CAH07_07325 ENOG4105C02 permease CAH07_07330 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) CAH07_07335 ENOG4105VBH UPF0297 protein CAH07_07340 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) CAH07_07345 ENOG4105VPH UPF0473 protein CAH07_07350 ENOG4105HHA aminodeoxychorismate lyase CAH07_07355 ENOG4108VQJ O-methyltransferase CAH07_07360 ENOG4105XYU peptidase (U32 family) CAH07_07365 ENOG4105CFP Peptidase U32 CAH07_07370 ENOG4105DBI uridine monophosphokinase CAH07_07375 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) CAH07_07380 ENOG4107XRG penicillin-binding protein CAH07_07395 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) CAH07_07410 ENOG4105C28 cystathionine CAH07_07425 ENOG4108JB9 formate dehydrogenase CAH07_07430 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) CAH07_07435 ENOG4105TMB Formate nitrite transporter CAH07_07450 ENOG41082JN Transcriptional regulator CAH07_07455 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CAH07_07460 ENOG4105WDR CAH07_07465 ENOG4105EXC Acyl-transferase CAH07_07470 ENOG4108P49 AntiSigma factor CAH07_07475 ENOG4105JVQ RNA Polymerase CAH07_07480 ENOG4108NGU Transcriptional regulator CAH07_07485 ENOG4105N14 lysine exporter protein LysE YggA CAH07_07490 ENOG4105C85 amino acid CAH07_07495 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family CAH07_07500 ENOG4105YHU PTS system CAH07_07505 ENOG4108IQ3 PTS system CAH07_07510 ENOG4105ETZ PTS System CAH07_07515 ENOG4105F3R pts system mannose fructose sorbose family iid CAH07_07520 ENOG4108HKT sucrose-6-phosphate hydrolase CAH07_07525 ENOG4108Z0Z intracellular protease Pfpi family CAH07_07530 ENOG4105DQ4 alcohol dehydrogenase CAH07_07540 ENOG4105VUF Transcriptional regulator CAH07_07555 ENOG4105E2A Dehydrogenase CAH07_07560 ENOG4105PGS Spore coat protein CAH07_07570 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase CAH07_07575 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein CAH07_07580 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein CAH07_07585 ENOG4108VQT Alpha beta hydrolase fold protein CAH07_07590 ENOG4105X5K response regulator receiver protein CAH07_07595 ENOG41083Q9 chitosanase CAH07_07600 ENOG4105C7F AcnD-accessory protein PrpF CAH07_07605 ENOG4108KAM Transcriptional regulator CAH07_07615 ENOG4105CPC Aldo Keto reductase CAH07_07620 ENOG410904A RNA polymerase CAH07_07625 ENOG4108MEK Metal-binding protein YodA CAH07_07655 ENOG4105EA8 2-Nitropropane dioxygenase CAH07_07660 ENOG41075D4 Aminoglycoside 6-adenylyltransferase CAH07_07670 ENOG41064BW Protein of unknown function (DUF2568) CAH07_07695 ENOG4108ZRZ Transcriptional regulator (AsnC family) CAH07_07700 ENOG4108UMN azlc family CAH07_07705 ENOG4105KMT branched-chain amino acid CAH07_07725 ENOG41090U3 tautomerase CAH07_07730 ENOG4105PGM cation diffusion facilitator family transporter CAH07_07735 ENOG4105H3G oxidoreductase CAH07_07740 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family CAH07_07755 ENOG4105C37 (CBS) domain CAH07_07770 ENOG41090E6 transcriptional regulator MERR family CAH07_07785 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein CAH07_07800 ENOG4105XTG Pfam:DUF156 CAH07_07805 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase CAH07_07815 ENOG4105VFE sira family CAH07_07830 ENOG4105VFE sira family CAH07_07835 ENOG41087NI Sulfite exporter TauE/SafE CAH07_07840 ENOG41068VA CAH07_07845 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CAH07_07850 ENOG4108UYN gCN5-related N-acetyltransferase CAH07_07855 ENOG4105DHF Membrane CAH07_07860 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CAH07_07865 ENOG4108SWU Histidine kinase CAH07_07880 ENOG4107Y5K Resolvase CAH07_07885 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CAH07_07895 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) CAH07_07905 ENOG41067QW Transcriptional regulator CAH07_07910 ENOG4106A7E Transcriptional regulator CAH07_07935 ENOG4108NF7 phage-type endonuclease CAH07_07940 ENOG4108PNI recT protein CAH07_07960 ENOG4105QBX endodeoxyribonuclease RusA CAH07_07970 ENOG4106129 CAH07_07990 ENOG4105IG6 Phage terminase, large subunit CAH07_07995 ENOG4108MDF Phage Portal Protein CAH07_08000 ENOG4106CGH Phage Mu protein F like protein CAH07_08035 ENOG41060SN CAH07_08050 ENOG4105PQS phage protein CAH07_08055 ENOG4105FR7 XkdM protein, phage-like element PBSX CAH07_08070 ENOG4105MTC XkdN-like protein CAH07_08080 ENOG4108FKH Transglycosylase SLT domain CAH07_08085 ENOG4108WZM domain protein CAH07_08090 ENOG4105X7F CAH07_08100 ENOG4105MFU Protein of unknown function (DUF2634) CAH07_08105 ENOG41066EA baseplate J family protein CAH07_08110 ENOG410906S phage-like element pbsx protein xkdt CAH07_08145 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase CAH07_08160 ENOG41064HX Suppressor of fused protein (SUFU) CAH07_08190 ENOG41085FC arsR family transcriptional regulator CAH07_08195 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase CAH07_08200 ENOG4105D6J arsenicaL-resistance protein CAH07_08205 ENOG4108UXE Protein tyrosine phosphatase CAH07_08215 ENOG4107Y5K Resolvase CAH07_08220 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CAH07_08225 ENOG4105WFK nuclease CAH07_08240 ENOG41080BT SNARE associated Golgi CAH07_08245 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CAH07_08260 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase CAH07_08265 ENOG4105CQW ribosome biogenesis GTPase YqeH CAH07_08270 ENOG4105E2X shikimate dehydrogenase CAH07_08275 ENOG410812S Rna-binding protein CAH07_08280 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) CAH07_08285 ENOG4108WF2 Metal Dependent Phosphohydrolase CAH07_08295 ENOG4108D32 Methyltransferase CAH07_08305 ENOG4105KQC Competence protein CAH07_08310 ENOG4108UK2 deaminase CAH07_08315 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 CAH07_08325 ENOG4105TQK DNA polymerase iii, delta' subunit CAH07_08330 ENOG41082YS Binds directly to 16S ribosomal RNA CAH07_08335 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) CAH07_08340 ENOG4108ZRV stage ii sporulation protein p CAH07_08350 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) CAH07_08355 ENOG4105CSA Coproporphyrinogen iii oxidase CAH07_08360 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) CAH07_08365 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ CAH07_08370 ENOG4105CFG Acts as a chaperone (By similarity) CAH07_08380 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) CAH07_08385 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) CAH07_08390 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CAH07_08405 ENOG4105KTH gatB Yqey CAH07_08410 ENOG4105F7J membrane-bound serine protease CAH07_08415 ENOG4105DI5 UPF0365 protein CAH07_08425 ENOG41068P3 sporulation protein YqfC CAH07_08430 ENOG4105EI1 sporulation protein yqfd CAH07_08435 ENOG4105C9A Phoh family CAH07_08440 ENOG4105CTJ Metal Dependent Phosphohydrolase CAH07_08445 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) CAH07_08450 ENOG4107YR5 Diacylglycerol kinase CAH07_08455 ENOG4105KG3 cytidine deaminase CAH07_08460 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) CAH07_08470 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) CAH07_08475 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit CAH07_08480 ENOG4105C38 Glycyl-tRNA synthetase beta subunit CAH07_08490 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) CAH07_08495 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 CAH07_08500 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) CAH07_08505 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CAH07_08525 ENOG4105EGD dinuclear metal center protein, YbgI family CAH07_08530 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) CAH07_08545 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) CAH07_08550 ENOG41069ZM Protein of unknown function (DUF2624) CAH07_08555 ENOG4108JYZ YitT family CAH07_08560 ENOG4105N80 Ferric uptake regulator, Fur family CAH07_08565 ENOG4108U5J '-nucleotidase CAH07_08570 ENOG41063Y9 CAH07_08575 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) CAH07_08590 ENOG4105SXS Protein of unknown function (DUF456) CAH07_08595 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CAH07_08605 ENOG4107RF6 penicillin-binding protein CAH07_08610 ENOG4105CVA phosphate CAH07_08615 ENOG4105C8U phosphate abc transporter CAH07_08620 ENOG4105E2Z phosphate ABC transporter (Permease CAH07_08625 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CAH07_08630 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CAH07_08635 ENOG41068DG YceG-like family CAH07_08655 ENOG4105WDJ 50S ribosomal protein L33 CAH07_08660 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase CAH07_08670 ENOG4107ZXI Rhomboid family CAH07_08685 ENOG4105E0M Sulfatase CAH07_08710 ENOG4105C5X domain protein CAH07_08735 ENOG4105C37 (CBS) domain CAH07_08800 ENOG4105VFR signal peptidase CAH07_08810 ENOG4108IMY Transcriptional regulator CAH07_08825 ENOG4105C0D helicase CAH07_08830 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CAH07_08835 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CAH07_08840 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CAH07_08845 ENOG4105WZW rhodanese family CAH07_08850 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) CAH07_08855 ENOG4105KST dependent repressor CAH07_08870 ENOG4105CBJ Metal-dependent enzyme CAH07_08880 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) CAH07_08885 ENOG4105DC7 peptidase M24 CAH07_08890 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) CAH07_08900 ENOG4105CD2 stage iii sporulation protein aa CAH07_08905 ENOG4105KR5 Stage iii sporulation protein CAH07_08910 ENOG4108CQH stage III sporulation protein AC CAH07_08915 ENOG4105KQ4 Stage iii sporulation protein ad CAH07_08925 ENOG410644B Stage III sporulation protein af CAH07_08945 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CAH07_08950 ENOG4108ZSR alkaline shock protein CAH07_08955 ENOG4105M7K Involved in the transcription termination process (By similarity) CAH07_08960 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CAH07_08965 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CAH07_08970 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) CAH07_08975 ENOG4105CTB Polyprenyl synthetase CAH07_08985 ENOG4105DX0 Hemolysin A CAH07_08990 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) CAH07_08995 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) CAH07_09000 ENOG4105S1Z Stage IV sporulation protein B CAH07_09005 ENOG4107QQR Sporulation CAH07_09010 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CAH07_09020 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CAH07_09025 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CAH07_09035 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase CAH07_09040 ENOG4105C1G acyl-Coa dehydrogenase CAH07_09050 ENOG4105DXD 2-methylcitrate dehydratase CAH07_09055 ENOG4105CR4 methylisocitrate lyase CAH07_09060 ENOG4106CCJ Protein of unknown function (DUF2627) CAH07_09065 ENOG4108JUB Transcriptional regulator CAH07_09075 ENOG4107RDP Dehydrogenase CAH07_09080 ENOG4105CKM Branched-chain carboxylic acid kinase CAH07_09095 ENOG4105CPP Dehydrogenase, E1 component CAH07_09100 ENOG4105C7S Dehydrogenase CAH07_09115 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) CAH07_09120 ENOG4108Y6J UPF0403 protein CAH07_09125 ENOG4108HW3 (ABC) transporter CAH07_09130 ENOG4105E5Q amino acid AbC transporter CAH07_09135 ENOG4105CDA abc transporter atp-binding protein CAH07_09140 ENOG4108QEG Membrane CAH07_09145 ENOG4108VZI ErfK ybiS ycfS ynhG family protein CAH07_09150 ENOG4108ZVT methylmalonyl-coA epimerase CAH07_09155 ENOG4108HNZ carboxyl transferase CAH07_09160 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) CAH07_09165 ENOG4108NA0 Uncharacterized conserved protein (COG2071) CAH07_09170 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) CAH07_09180 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CAH07_09185 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CAH07_09190 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase CAH07_09195 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) CAH07_09200 ENOG410861F 50S ribosomal protein L33 CAH07_09210 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CAH07_09220 ENOG4105II7 pyrroline-5-carboxylate reductase CAH07_09225 ENOG41069FQ Metallo-beta-lactamase superfamily CAH07_09230 ENOG4108IXY short-chain dehydrogenase reductase CAH07_09245 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase CAH07_09255 ENOG4105E5W Transporter CAH07_09265 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) CAH07_09275 ENOG4108XET gCN5-related N-acetyltransferase CAH07_09280 ENOG4105KAC Antibiotic biosynthesis monooxygenase CAH07_09285 ENOG4105RHY Pfam:UPF0157 CAH07_09290 ENOG4106HZJ CAH07_09310 ENOG4105CPC Aldo Keto reductase CAH07_09320 ENOG4108YZ4 nudix hydrolase CAH07_09330 ENOG4108IMY Transcriptional regulator CAH07_09335 ENOG4105HDK L-asparaginase CAH07_09340 ENOG4108IJ0 Aspartate ammonia-lyase CAH07_09345 ENOG4105DFD Na H antiporter CAH07_09360 ENOG4105MZ9 stage II sporulation protein m CAH07_09365 ENOG4105I3K Ferric uptake regulator, Fur family CAH07_09375 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CAH07_09380 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) CAH07_09385 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) CAH07_09390 ENOG4105DZ1 carboxypeptidase CAH07_09395 ENOG41082AN stage II sporulation protein CAH07_09400 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) CAH07_09405 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CAH07_09420 ENOG41090VF Stage v sporulation protein ac CAH07_09425 ENOG4105CZ3 stage V sporulation protein ad CAH07_09435 ENOG4105G6R Stage v sporulation protein ae CAH07_09445 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CAH07_09450 ENOG4105PTM secreted protein CAH07_09460 ENOG4107ZE5 PPIases accelerate the folding of proteins CAH07_09480 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) CAH07_09490 ENOG4105C3F Signal peptidase i CAH07_09500 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) CAH07_09505 ENOG4108R6K riboflavin synthase, subunit alpha CAH07_09510 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) CAH07_09515 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) CAH07_09530 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) CAH07_09535 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) CAH07_09545 ENOG4105DZ1 carboxypeptidase CAH07_09550 ENOG4108JIC nucleoside recognition domain protein CAH07_09560 ENOG4105FE9 pseudouridine synthase CAH07_09570 ENOG4107TWT Cytochrome c biogenesis protein CAH07_09575 ENOG4105CRE cytochrome C CAH07_09580 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CAH07_09585 ENOG4105BZU Histidine kinase CAH07_09600 ENOG4105FF2 Type I DHQase CAH07_09605 ENOG4108JQ1 Dehydrogenase CAH07_09610 ENOG4108SAX Membrane CAH07_09620 ENOG4105T7X CAH07_09625 ENOG4105C9U ATP-dependent DNA helicase RecQ CAH07_09630 ENOG4105I7S Abortive infection protein CAH07_09645 ENOG4107RGJ metallophosphoesterase CAH07_09660 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase CAH07_09665 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) CAH07_09675 ENOG4105MSI germination protein ypeb CAH07_09690 ENOG4105CAT Cytidine monophosphate kinase CAH07_09695 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CAH07_09700 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) CAH07_09715 ENOG4105S2F CAH07_09720 ENOG41065D1 CAH07_09725 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CAH07_09730 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase CAH07_09745 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) CAH07_09750 ENOG4105K70 DNA-binding protein CAH07_09755 ENOG4105EUJ GTP cyclohydrolase i CAH07_09765 ENOG4105XXQ heptaprenyl diphosphate synthase component I CAH07_09770 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CAH07_09775 ENOG4105EAH synthase CAH07_09780 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) CAH07_09785 ENOG4105BZU Histidine kinase CAH07_09790 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CAH07_09795 ENOG4105D49 3-dehydroquinate synthase CAH07_09800 ENOG4105KHN chorismate mutase CAH07_09805 ENOG4105CRQ synthase (Component I) CAH07_09810 ENOG4108I0Q anthranilate phosphoribosyltransferase CAH07_09820 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase CAH07_09825 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CAH07_09835 ENOG4105CIH Imidazole acetol-phosphate transaminase CAH07_09845 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CAH07_09850 ENOG41068YB TPR repeat-containing protein CAH07_09870 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) CAH07_09890 ENOG4108JYZ YitT family CAH07_09895 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase CAH07_09900 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) CAH07_09905 ENOG4108Z5K methylglyoxal synthase CAH07_09910 ENOG4105FJR Lmbe family CAH07_09915 ENOG4105CPK Glycosyl transferase (Group 1 CAH07_09920 ENOG4105DJ0 Poly(A) Polymerase CAH07_09925 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase CAH07_09930 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) CAH07_09935 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) CAH07_09940 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) CAH07_09945 ENOG4105DVT helicase CAH07_09950 ENOG4105YAC CAH07_09960 ENOG4105CHM Aminotransferase CAH07_09965 ENOG4105C5S asparaginyl-tRNA synthetase CAH07_09975 ENOG4105CSM endonuclease III CAH07_09985 ENOG4105BZ4 penicillin-binding protein CAH07_10035 ENOG4108I5C dEAD DEAH box helicase CAH07_10040 ENOG4107X2U Inherit from COG: Exonuclease-like protein CAH07_10050 ENOG4108UKS UPF0398 protein CAH07_10065 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) CAH07_10080 ENOG4105DVT helicase CAH07_10085 ENOG4105CHR reductase CAH07_10095 ENOG4108M60 Transcriptional regulator CAH07_10100 ENOG4105D7K pfkb domain protein CAH07_10105 ENOG4108UHU Aldolase CAH07_10110 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) CAH07_10115 ENOG4105CTD carboxy-peptidase CAH07_10120 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) CAH07_10130 ENOG41065KQ synthase CAH07_10140 ENOG410890F Dynamin family CAH07_10165 ENOG41081VK Ribonuclease CAH07_10205 ENOG4105CVG Homoserine O-transsuccinylase CAH07_10210 ENOG4108V06 Glutathione peroxidase CAH07_10225 ENOG4105C01 Dihydroxy-acid dehydratase CAH07_10230 ENOG4108Y6J UPF0403 protein CAH07_10235 ENOG4107YX5 Pfam:DUF548 CAH07_10250 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) CAH07_10255 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) CAH07_10265 ENOG4108UT2 hemolysin iii CAH07_10275 ENOG4105C7B Threonine dehydratase CAH07_10285 ENOG4108KF3 Electron transport protein SCO1 SenC CAH07_10290 ENOG41090WU lipolytic protein G-D-S-L family CAH07_10295 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) CAH07_10315 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) CAH07_10320 ENOG4105E0X reductase CAH07_10325 ENOG4105C5E polysaccharide biosynthesis protein CAH07_10330 ENOG4107T32 3-phytase (EC 3.1.3.8) CAH07_10365 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CAH07_10380 ENOG4107S4Y M20 DapE family protein YgeY CAH07_10385 ENOG4108TSC N-acetyltransferase CAH07_10390 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein CAH07_10425 ENOG410841Q phosphoesterase PA-phosphatase related protein CAH07_10430 ENOG4106Z5R CAH07_10440 ENOG4105D3A purine nucleoside phosphorylase DeoD-type CAH07_10445 ENOG4108VXD carboxy-peptidase CAH07_10465 ENOG4105E1V na solute symporter CAH07_10480 ENOG4105FBA Phospholipase Carboxylesterase CAH07_10495 ENOG41090U3 tautomerase CAH07_10500 ENOG4105C6Z Gluconate CAH07_10515 ENOG4105FR1 rard protein CAH07_10535 ENOG4106SCS STAS domain CAH07_10540 ENOG4107QMU Mate efflux family protein CAH07_10550 ENOG41087PP glycosyltransferase MGT family CAH07_10555 ENOG4105K4H Nlp p60 protein CAH07_10565 ENOG4105GMT ATPase associated with various cellular activities aaa_5 CAH07_10570 ENOG4107T89 von Willebrand factor, type A CAH07_10580 ENOG4105C7S Dehydrogenase CAH07_10585 ENOG4105C09 Bile acid CAH07_10590 ENOG4105C8J )-transporter CAH07_10595 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) CAH07_10600 ENOG4105EWU Squalene--hopene cyclase CAH07_10605 ENOG4105C26 Dehydrogenase CAH07_10650 ENOG4105SCY DNAK suppressor CAH07_10655 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) CAH07_10670 ENOG4105C9U ATP-dependent DNA helicase RecQ CAH07_10675 ENOG41069ER domain protein CAH07_10680 ENOG4108S01 response regulator CAH07_10685 ENOG4108ZGX Histidine kinase CAH07_10690 ENOG4105ECK Fatty Acid Desaturase CAH07_10710 ENOG4108SJC Membrane CAH07_10720 ENOG4105KTU Transcriptional regulator, arsr family CAH07_10730 ENOG4105D29 Helix-turn-helix type 11 domain protein CAH07_10740 ENOG4108W8B Beta-lactamase domain protein CAH07_10750 ENOG4108HJF gCN5-related N-acetyltransferase CAH07_10755 ENOG4105FTV AraC Family Transcriptional Regulator CAH07_10760 ENOG4108Z7R Chaperone CsaA CAH07_10775 ENOG4106BHF CAH07_10780 ENOG4106ANW SMI1_KNR4 CAH07_10785 ENOG41066F8 ROK family CAH07_10795 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CAH07_10800 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component CAH07_10815 ENOG4105CS2 ec 3.2.1.21 CAH07_10820 ENOG4105ETE Transcriptional regulator (LacI family CAH07_10825 ENOG4105D3P Mannan endo-1,4-beta-mannosidase CAH07_10845 ENOG4108RAV Conserved protein CAH07_10860 ENOG4108IMY Transcriptional regulator CAH07_10865 ENOG4105YB8 TM2 domain containing protein CAH07_10875 ENOG4107T94 Endo-14-beta-xylanase CAH07_10880 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) CAH07_10900 ENOG4108J4B Beta-lactamase CAH07_10905 ENOG4108V4B ThiJ pfpI CAH07_10915 ENOG4108Q5Y Membrane CAH07_10925 ENOG4105NX3 Membrane CAH07_10930 ENOG4105VMP Transcriptional regulator CAH07_10940 ENOG41073R8 VanW family CAH07_10960 ENOG4105EPI acetyltransferase, (GNAT) family CAH07_10970 ENOG4105F0F Oxalate decarboxylase CAH07_10980 ENOG4108RAV Conserved protein CAH07_10985 ENOG4108NR7 pectate lyase CAH07_10990 ENOG4105XPP Protein of unknown function (DUF1275) CAH07_10995 ENOG4108YQE rare lipoprotein a CAH07_11005 ENOG4105EC8 Methyl-accepting chemotaxis CAH07_11030 ENOG4108J2R molybdopterin oxidoreductase CAH07_11035 ENOG4108M3J Dehydrogenase CAH07_11040 ENOG4107U6E carbohydrate kinase FGGY CAH07_11045 ENOG4105IE8 Alpha-ketoglutarate permease CAH07_11060 ENOG41068WN CAH07_11085 ENOG4105II7 pyrroline-5-carboxylate reductase CAH07_11090 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) CAH07_11095 ENOG4105C5Q Transcriptional regulator CAH07_11100 ENOG4105CBC glutamate synthase CAH07_11105 ENOG4105BZ8 glutamate synthase CAH07_11110 ENOG4105CB2 alcohol dehydrogenase CAH07_11115 ENOG4105SKE transcriptional Regulator LysR family CAH07_11120 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) CAH07_11145 ENOG4107QJQ Mate efflux family protein CAH07_11150 ENOG4108N2V aldose 1-epimerase CAH07_11155 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family CAH07_11160 ENOG4105C0W non-ribosomal peptide synthetase CAH07_11170 ENOG4105C0W non-ribosomal peptide synthetase CAH07_11175 ENOG4105CEY Amp-dependent synthetase and ligase CAH07_11185 ENOG4106U2H Protein of unknown function (DUF1360) CAH07_11190 ENOG4105F32 YngK protein CAH07_11200 ENOG4105C1G acyl-Coa dehydrogenase CAH07_11205 ENOG4105CEY Amp-dependent synthetase and ligase CAH07_11210 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase CAH07_11215 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit CAH07_11220 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase CAH07_11225 ENOG4105E39 Enoyl-CoA hydratase CAH07_11230 ENOG4107QX3 carboxylase CAH07_11240 ENOG4107T5V SNARE associated Golgi CAH07_11245 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CAH07_11255 ENOG4107SYN Glycosyl hydrolases family 43 CAH07_11260 ENOG4108MYR Secreted protein CAH07_11270 ENOG4107QWR cellulase (EC 3.2.1.4) CAH07_11290 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CAH07_11295 ENOG4105K4P CoA-binding domain protein CAH07_11300 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) CAH07_11305 ENOG4105W8X HesB YadR YfhF-family protein CAH07_11310 ENOG4105MI2 CAH07_11320 ENOG41067CD Small, acid-soluble spore protein Tlp CAH07_11335 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CAH07_11340 ENOG4108I0Z Aconitate hydratase CAH07_11350 ENOG4107DZX Small, acid-soluble spore protein P CAH07_11375 ENOG4107QIV Cytochrome c biogenesis protein CAH07_11395 ENOG4105CV1 Transketolase (EC 2.2.1.1) CAH07_11400 ENOG4105VPS UPF0291 protein CAH07_11405 ENOG4108SVB resolvase CAH07_11415 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) CAH07_11425 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) CAH07_11435 ENOG4105K7W phage-related replication protein CAH07_11445 ENOG4105FVX CAH07_11460 ENOG4108NHD germination protein CAH07_11465 ENOG4108Q8B Spore germination protein CAH07_11530 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) CAH07_11540 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CAH07_11545 ENOG4105C54 Major Facilitator superfamily CAH07_11550 ENOG4107Y9E nuclease CAH07_11560 ENOG4105CMG Carbohydrate kinase CAH07_11565 ENOG4105C93 Xylose Isomerase CAH07_11570 ENOG4105E2R ROK family CAH07_11575 ENOG4105DSG hydrolase family 43 CAH07_11580 ENOG4105CT4 transporter CAH07_11585 ENOG410907G CAH07_11600 ENOG4107NTZ CAH07_11630 ENOG4107RGC Glycosyl transferase, family 2 CAH07_11635 ENOG4106WTF Glycosyl transferase, family 2 CAH07_11665 ENOG4105C5F glutamine synthetase CAH07_11670 ENOG4105KV4 Transcriptional regulator CAH07_11675 ENOG4105CXI aluminum resistance protein CAH07_11680 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CAH07_11685 ENOG4106F1P AAA ATPase, central domain protein CAH07_11695 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase CAH07_11700 ENOG4105U6W MutT NUDIX family protein CAH07_11705 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CAH07_11710 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CAH07_11715 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CAH07_11730 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) CAH07_11735 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) CAH07_11755 ENOG410814C multidrug resistance protein CAH07_11760 ENOG4108X3M OsmC Ohr family protein CAH07_11765 ENOG4105K7W phage-related replication protein CAH07_11775 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CAH07_11790 ENOG4106A3M Cytochrome p-450 CAH07_11800 ENOG4105C0W non-ribosomal peptide synthetase CAH07_11810 ENOG4107SQU synthase CAH07_11815 ENOG4105C0W non-ribosomal peptide synthetase CAH07_11820 ENOG4108KQ6 Enoyl-CoA hydratase CAH07_11825 ENOG4108MGH Enoyl-CoA hydratase CAH07_11830 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase CAH07_11835 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase CAH07_11840 ENOG41062T2 Acyl carrier protein CAH07_11845 ENOG4107QKG PfaD family CAH07_11855 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CAH07_11865 ENOG4108151 Beta-lactamase domain protein CAH07_11870 ENOG4105W1N transcriptional regulator CAH07_11875 ENOG4105IIP Membrane CAH07_11885 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) CAH07_11890 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) CAH07_11905 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CAH07_11910 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CAH07_11920 ENOG4105MCT stage V sporulation protein S CAH07_11925 ENOG4105D48 metallophosphoesterase CAH07_11930 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) CAH07_11935 ENOG4108A04 Beta-lactamase CAH07_11945 ENOG4105CEV competence damage-inducible protein CAH07_11950 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase CAH07_11965 ENOG4105XZV Protein of unknown function (DUF3243) CAH07_11970 ENOG4108RKS Short-chain dehydrogenase reductase Sdr CAH07_11990 ENOG4105FDP GntR family transcriptional regulator CAH07_11995 ENOG4105CNU cell division protein FtsK CAH07_12005 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit CAH07_12015 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CAH07_12025 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) CAH07_12030 ENOG4108S0H Dipicolinic acid synthetase, b subunit CAH07_12035 ENOG4105E35 Dipicolinate synthase subunit A CAH07_12045 ENOG4105C1V Peptidase, M16 CAH07_12055 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) CAH07_12060 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) CAH07_12065 ENOG4105DTN riboflavin biosynthesis protein ribF CAH07_12070 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CAH07_12075 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) CAH07_12080 ENOG4105W7A Protein of unknown function (DUF503) CAH07_12085 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) CAH07_12090 ENOG4105VHM ribosomal protein CAH07_12095 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination CAH07_12100 ENOG4105CHV Transcription elongation factor NusA CAH07_12105 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) CAH07_12110 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CAH07_12115 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) CAH07_12120 ENOG4105DZP Membrane-associated zinc metalloprotease CAH07_12130 ENOG4105KNE Phosphatidate cytidylyltransferase CAH07_12135 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) CAH07_12140 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) CAH07_12150 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) CAH07_12155 ENOG4105CE9 30S ribosomal protein S2 CAH07_12165 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CAH07_12180 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis CAH07_12185 ENOG4105CBS Chea signal transduction histidine kinase CAH07_12190 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) CAH07_12200 ENOG4105FZW flagellar biosynthesis regulator FlhF CAH07_12205 ENOG4105D7B Flagellar biosynthesis protein flha CAH07_12210 ENOG4105D00 flagellar biosynthetic protein flhB CAH07_12215 ENOG4105D19 Role in flagellar biosynthesis (By similarity) CAH07_12220 ENOG4105VS8 Flagellar biosynthetic protein fliq CAH07_12225 ENOG4105CN7 Flagellar biosynthetic protein FliP CAH07_12235 ENOG4107YTP response regulator receiver protein CAH07_12240 ENOG4105DD5 Flagellar motor switch protein CAH07_12245 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CAH07_12255 ENOG41068WV flagellar FlbD family protein CAH07_12260 ENOG4108JQA flagellar CAH07_12265 ENOG410822I Flagellar hook capping protein CAH07_12270 ENOG410696Y Flagellar hook-length control protein CAH07_12280 ENOG4106YF4 Flagellar biosynthesis chaperone CAH07_12295 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) CAH07_12300 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) CAH07_12305 ENOG4105VQ0 flagellar hook-basal body complex protein fliE CAH07_12310 ENOG4108ZC9 flagellar basal-body rod protein flgc CAH07_12315 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) CAH07_12325 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) CAH07_12330 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) CAH07_12335 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CAH07_12340 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) CAH07_12345 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CAH07_12350 ENOG4105C79 DNA protecting protein DprA CAH07_12355 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha CAH07_12360 ENOG4105CMV Succinyl-CoA synthetase subunit beta CAH07_12365 ENOG4105VM1 flagellar CAH07_12375 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) CAH07_12380 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) CAH07_12385 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) CAH07_12390 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) CAH07_12395 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) CAH07_12405 ENOG4108BW8 UPF0109 protein CAH07_12410 ENOG4105K5M 30s ribosomal protein S16 CAH07_12420 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) CAH07_12430 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) CAH07_12435 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) CAH07_12440 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) CAH07_12445 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) CAH07_12450 ENOG4105CHR reductase CAH07_12455 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase CAH07_12465 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) CAH07_12470 ENOG4105CB5 ATP-dependent DNA helicase recG CAH07_12475 ENOG4105EJQ L-serine dehydratase CAH07_12485 ENOG4105DP4 dak2 domain fusion protein ylov CAH07_12490 ENOG4108ZAA Alkaline-shock protein CAH07_12495 ENOG4105VB9 50S ribosomal protein l28 CAH07_12505 ENOG4105FJ0 thiamine CAH07_12510 ENOG4105DJV ribulose-phosphate 3-epimerase CAH07_12515 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CAH07_12520 ENOG4105D9P serine threonine protein kinase CAH07_12525 ENOG4108ZF3 Phosphatase CAH07_12530 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs CAH07_12535 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B CAH07_12540 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) CAH07_12545 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CAH07_12550 ENOG4105C25 Primosomal protein n' CAH07_12555 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase CAH07_12565 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) CAH07_12570 ENOG4105KC4 UPF0296 protein CAH07_12575 ENOG4105DSJ YicC domain protein CAH07_12585 ENOG4105F23 Fibronectin-binding protein CAH07_12590 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein CAH07_12595 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein CAH07_12600 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CAH07_12605 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) CAH07_12610 ENOG4107S4M Sulfate adenylate transferase CAH07_12620 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) CAH07_12625 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CAH07_12630 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) CAH07_12635 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) CAH07_12640 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) CAH07_12645 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CAH07_12650 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CAH07_12660 ENOG4105CXT aspartate transcarbamylase CAH07_12670 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) CAH07_12675 ENOG4105C34 Pseudouridine synthase CAH07_12680 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CAH07_12690 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) CAH07_12700 ENOG4105DBK s4 domain protein CAH07_12705 ENOG41067XK integral membrane protein CAH07_12710 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) CAH07_12715 ENOG4105DFA alanine racemase domain protein CAH07_12720 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CAH07_12725 ENOG4105WR5 sporulation protein, YlmC YmxH family CAH07_12735 ENOG4105DKW ABC transporter CAH07_12745 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) CAH07_12750 ENOG4105FFI sigma-e processing peptidase spoiiga CAH07_12760 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CAH07_12765 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) CAH07_12770 ENOG4105K67 small basic protein CAH07_12780 ENOG4108R2U division initiation protein CAH07_12785 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) CAH07_12790 ENOG4105D4A Cell wall formation (By similarity) CAH07_12795 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) CAH07_12800 ENOG4105CNI cell division protein FtsW CAH07_12805 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) CAH07_12810 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) CAH07_12815 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CAH07_12820 ENOG4105CJN penicillin-binding protein CAH07_12825 ENOG4105CJN penicillin-binding protein CAH07_12835 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) CAH07_12840 ENOG4108V6E Cell division protein mraZ CAH07_12865 ENOG41067VY 50S ribosomal protein L32 CAH07_12870 ENOG4105KNH Nucleic acid-binding protein CAH07_12880 ENOG4105CDE UPF0348 protein CAH07_12885 ENOG41063PX domain protein CAH07_12890 ENOG4105D78 K07001 NTE family protein CAH07_12895 ENOG4105H20 Sporulation integral membrane protein YlbJ CAH07_12900 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) CAH07_12905 ENOG4106H78 methyltransferase CAH07_12910 ENOG4105WUC UPF0298 protein CAH07_12930 ENOG4106UY4 Inherit from COG: Scp-like extracellular CAH07_12935 ENOG41080XQ Signal transduction protein with cbs domains CAH07_12950 ENOG41064X9 cytochrome C oxidase subunit IV CAH07_12955 ENOG4105CCU oxidase (Subunit III) CAH07_12960 ENOG4105BZ9 Cytochrome C oxidase, subunit I CAH07_12970 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) CAH07_12980 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) CAH07_12985 ENOG4105CNI cell division protein FtsW CAH07_12990 ENOG4105ZPI UPF0358 protein CAH07_12995 ENOG4105CSV Glutaminase CAH07_13005 ENOG4108IAB Phoh family CAH07_13020 ENOG4105QA2 CAH07_13025 ENOG4105CI3 gtp-binding protein typa CAH07_13065 ENOG4105JQZ Methyltransferase CAH07_13075 ENOG4105ECY inositol monophosphatase CAH07_13090 ENOG4105WBI UPF0223 protein CAH07_13095 ENOG4105CXN decarboxylase CAH07_13110 ENOG4107QN2 dihydrolipoyl dehydrogenase CAH07_13115 ENOG4105C7S Dehydrogenase CAH07_13120 ENOG4105CPP Dehydrogenase, E1 component CAH07_13140 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CAH07_13145 ENOG4108X4Q Hydrolase CAH07_13155 ENOG4105CN5 Metallo-Beta-Lactamase CAH07_13165 ENOG4107ZYR domain protein CAH07_13175 ENOG4105BZU Histidine kinase CAH07_13200 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) CAH07_13205 ENOG4105C5H ABC transporter CAH07_13215 ENOG4105C3F Signal peptidase i CAH07_13220 ENOG4105DM4 PTS System CAH07_13225 ENOG4105DE4 1-phosphofructokinase CAH07_13230 ENOG4105E98 transcriptional regulator DeoR family CAH07_13235 ENOG4107RBB ABC transporter, permease CAH07_13240 ENOG4105C19 ABC transporter CAH07_13245 ENOG4107X8C Efflux transporter RND family MFP subunit CAH07_13255 ENOG4105BZ1 (ABC) transporter CAH07_13260 ENOG4105BZ1 (ABC) transporter CAH07_13265 ENOG41067WU Molybdopterin converting factor (Subunit 1) CAH07_13270 ENOG4108ZAF Molybdopterin CAH07_13275 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein CAH07_13280 ENOG4105CVM Molybdenum cofactor synthesis domain protein CAH07_13285 ENOG4105D06 uba thif-type nad fad binding protein CAH07_13290 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) CAH07_13305 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CAH07_13310 ENOG4105D3R alkyl hydroperoxide reductase CAH07_13315 ENOG4105D8X mechanosensitive ion channel CAH07_13325 ENOG4105CH2 amidohydrolase CAH07_13335 ENOG4105NQC Flavodoxin CAH07_13365 ENOG4108XRC Protein of unknown function (DUF458) CAH07_13370 ENOG4107IN1 Protein of unknown function (DUF1797) CAH07_13375 ENOG4105EPM Diguanylate phosphodiesterase CAH07_13380 ENOG4105K6S Short-chain dehydrogenase reductase Sdr CAH07_13390 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein CAH07_13400 ENOG4105UIN CAH07_13405 ENOG4107R88 Chemotaxis protein (CheV) CAH07_13415 ENOG4105CHM Aminotransferase CAH07_13420 ENOG4105BZU Histidine kinase CAH07_13430 ENOG4105K4I Scp-like extracellular CAH07_13435 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase CAH07_13440 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer CAH07_13450 ENOG4105F6S Spore photoproduct lyase CAH07_13460 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CAH07_13465 ENOG4105KRI phosphocarrier protein (HPr CAH07_13475 ENOG4105CID antiterminator CAH07_13485 ENOG4105DC7 peptidase M24 CAH07_13495 ENOG4105C59 p-type ATPase CAH07_13510 ENOG4105F0V Cell wall hydrolase CAH07_13540 ENOG4105FEA Spore maturation protein CAH07_13545 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr CAH07_13555 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) CAH07_13560 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) CAH07_13565 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase CAH07_13570 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) CAH07_13575 ENOG4108K88 Membrane CAH07_13590 ENOG4105E14 MotA TolQ exbB proton channel CAH07_13595 ENOG4105ER2 Ompa motb domain protein CAH07_13600 ENOG41090MY MarR family Transcriptional regulator CAH07_13605 ENOG4105BZU Histidine kinase CAH07_13625 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) CAH07_13630 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) CAH07_13635 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) CAH07_13640 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit CAH07_13650 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase CAH07_13655 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) CAH07_13660 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) CAH07_13665 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CAH07_13670 ENOG4105BZU Histidine kinase CAH07_13675 ENOG4108TGC Acyltransferase CAH07_13695 ENOG4105D0M Protease HtpX homolog CAH07_13705 ENOG410681C small acid-soluble spore protein CAH07_13715 ENOG4108WZW RNA polymerase sigma CAH07_13720 ENOG4107TS3 membrane protein, TerC CAH07_13725 ENOG4107T5V SNARE associated Golgi CAH07_13730 ENOG4105BZU Histidine kinase CAH07_13735 ENOG4105FDF Could be involved in DNA repair (By similarity) CAH07_13740 ENOG4105DQE DNA ligase CAH07_13785 ENOG4105V75 Transcriptional regulator CAH07_13790 ENOG4105CJW magnesium transporter CAH07_13805 ENOG4106849 propeptide, pepSY amd peptidase M4 CAH07_13815 ENOG41062D9 Histidine kinase CAH07_13820 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CAH07_13825 ENOG4108X43 YKOF domain protein CAH07_13830 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein CAH07_13835 ENOG4108JJB ABC transporter CAH07_13840 ENOG4108W7F transporter, permease CAH07_13850 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CAH07_13855 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) CAH07_13860 ENOG4107Y2X deaminase CAH07_13870 ENOG4108ZHJ Organic hydroperoxide resistance protein CAH07_13875 ENOG4105K56 Transcriptional regulator CAH07_13890 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) CAH07_13895 ENOG4105CIY formyltetrahydrofolate deformylase CAH07_13900 ENOG41080TC multidrug resistance protein CAH07_13910 ENOG4108428 Inherit from COG: -acetyltransferase CAH07_13930 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) CAH07_13935 ENOG4108S4H thioesterase Superfamily protein CAH07_13940 ENOG4107TUM Amidinotransferase CAH07_13945 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) CAH07_13950 ENOG4108JQ7 (ABC) transporter CAH07_13955 ENOG4107SN7 NLP P60 protein CAH07_13960 ENOG4105DTQ mandelate racemase muconate lactonizing CAH07_13965 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A CAH07_13975 ENOG4105C3U ABC transporter CAH07_13980 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CAH07_13985 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CAH07_13990 ENOG4108ME1 Peptidase M55 D-aminopeptidase CAH07_14000 ENOG4105C0H protease CAH07_14005 ENOG4105CKK Glycosyl transferase, family 2 CAH07_14010 ENOG4105EDW glycosyl transferase, family 39 CAH07_14020 ENOG4107R7I amino acid CAH07_14025 ENOG4107GRR phosphate transport regulator CAH07_14030 ENOG4105CJ3 phosphate transporter CAH07_14045 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CAH07_14075 ENOG41068G1 CAH07_14085 ENOG410906S phage-like element pbsx protein xkdt CAH07_14090 ENOG41066EA baseplate J family protein CAH07_14095 ENOG4105MFU Protein of unknown function (DUF2634) CAH07_14105 ENOG4105X7F CAH07_14110 ENOG4108WZM domain protein CAH07_14115 ENOG4108FKH Transglycosylase SLT domain CAH07_14125 ENOG4105MTC XkdN-like protein CAH07_14130 ENOG4105FR7 XkdM protein, phage-like element PBSX CAH07_14135 ENOG4105PQS phage protein CAH07_14150 ENOG41060SN CAH07_14175 ENOG4108MDF Phage Portal Protein CAH07_14180 ENOG4105IG6 Phage terminase, large subunit CAH07_14185 ENOG4108TFU terminase (Small subunit) CAH07_14230 ENOG410635T phage-like element pbsx protein CAH07_14235 ENOG4105WEF catalase CAH07_14240 ENOG4105K7W phage-related replication protein CAH07_14245 ENOG4105KWG Pfam:DUF1696 CAH07_14250 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase CAH07_14255 ENOG41068K0 YCII-related domain CAH07_14270 ENOG4105JD4 ATPase yjob CAH07_14280 ENOG4107TSN permease CAH07_14285 ENOG4105CTX dehydratase CAH07_14290 ENOG4107QZW Altronate oxidoreductase CAH07_14295 ENOG4107KJX Transcriptional regulator CAH07_14300 ENOG4108I5G Major Facilitator superfamily CAH07_14305 ENOG4105DMW Dehydrogenase reductase CAH07_14310 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) CAH07_14315 ENOG4105CPQ Dehydrogenase CAH07_14320 ENOG4105DG4 malate L-lactate dehydrogenase CAH07_14325 ENOG4105CT4 transporter CAH07_14330 ENOG4105D2H Uronic isomerase CAH07_14345 ENOG4105Q95 Cupin 2, conserved barrel domain protein CAH07_14355 ENOG4108IXI (ABC) transporter CAH07_14360 ENOG4105C4B ABC transporter, permease CAH07_14365 ENOG4105EXQ uroporphyrinogen iii synthase hem4 CAH07_14375 ENOG41087PP glycosyltransferase MGT family CAH07_14380 ENOG4106A3M Cytochrome p-450 CAH07_14405 ENOG4108IEG Formate dehydrogenase Alpha subunit CAH07_14430 ENOG4107CUJ Protein of unknown function (DUF2690) CAH07_14435 ENOG4108ZJ4 polysaccharide deacetylase CAH07_14445 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) CAH07_14465 ENOG4108Z66 YbaK ebsC protein CAH07_14475 ENOG4105VMI -acetyltransferase CAH07_14480 ENOG4105G7B Protein of unknown function (DUF2992) CAH07_14485 ENOG4105DG6 mannose-6-phosphate isomerase CAH07_14490 ENOG4105DM4 PTS System CAH07_14505 ENOG4108PSK reductase CAH07_14530 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase CAH07_14535 ENOG4106BHF CAH07_14590 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase CAH07_14720 ENOG4107KNS CAH07_14840 ENOG4108ZUE Phage regulatory protein rha CAH07_14865 ENOG410635T phage-like element pbsx protein CAH07_14870 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CAH07_14880 ENOG4105JHY Membrane CAH07_14885 ENOG4105D9U N-acetyltransferase CAH07_14890 ENOG4105C28 cystathionine CAH07_14895 ENOG4105C28 cystathionine CAH07_14905 ENOG4108ZMI UPF0477 protein CAH07_14920 ENOG4105ENA helicase CAH07_14970 ENOG4107A88 CAH07_14975 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH CAH07_14980 ENOG4105DWF phosphomethylpyrimidine kinase CAH07_14985 ENOG4105D06 uba thif-type nad fad binding protein CAH07_14990 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) CAH07_15005 ENOG4108VEU Thiamine monophosphate synthase CAH07_15010 ENOG4105ETU transcriptional activator (TenA CAH07_15025 ENOG4105EMS pseudouridine synthase CAH07_15030 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) CAH07_15045 ENOG4105MIX Adenylate cyclase CAH07_15050 ENOG4105E4C Lytic transglycosylase catalytic CAH07_15055 ENOG4108Z18 K06886 hemoglobin CAH07_15060 ENOG4105T58 Dithiol-disulfide isomerase CAH07_15075 ENOG4105DPN Oligoendopeptidase f CAH07_15085 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis CAH07_15090 ENOG4108ZCF integral membrane protein CAH07_15095 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) CAH07_15110 ENOG4108JQ7 (ABC) transporter CAH07_15120 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CAH07_15125 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CAH07_15130 ENOG4108J59 Extracellular solute-binding protein, family 5 CAH07_15135 ENOG4105C31 Tryptophanyl-tRNA synthetase CAH07_15145 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CAH07_15160 ENOG4108JQ7 (ABC) transporter CAH07_15165 ENOG4105C3U ABC transporter CAH07_15175 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) CAH07_15180 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) CAH07_15195 ENOG4107RMD Basic membrane lipoprotein CAH07_15220 ENOG4105DBV ornithine carbamoyltransferase CAH07_15230 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain CAH07_15235 ENOG4105C8Y Acetylornithine aminotransferase CAH07_15250 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase CAH07_15260 ENOG4105IQ5 FAD linked oxidase domain protein CAH07_15270 ENOG4105VG1 fes assembly suf system protein CAH07_15275 ENOG4108MXZ Esterase CAH07_15280 ENOG4108KP7 hydrolase CAH07_15285 ENOG41073B9 CAH07_15295 ENOG4107AYK membrAne CAH07_15300 ENOG4105EPR degv family CAH07_15305 ENOG4105D4Y metalloprotease CAH07_15310 ENOG410751J CAH07_15320 ENOG4105K7K Transcriptional regulator CAH07_15340 ENOG4105QNR S1 RNA binding domain protein CAH07_15345 ENOG4108VPT UPF0234 protein CAH07_15355 ENOG4105MA6 gCN5-related N-acetyltransferase CAH07_15360 ENOG4108SZE gCN5-related N-acetyltransferase CAH07_15365 ENOG4107RCC Major Facilitator Superfamily CAH07_15370 ENOG4105DIA mandelate racemase muconate lactonizing CAH07_15380 ENOG41061P3 phosphosulfolactate synthase CAH07_15385 ENOG4108N5B 2-phosphosulfolactate phosphatase CAH07_15390 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) CAH07_15395 ENOG4107RIQ Sulfate adenylate transferase CAH07_15400 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) CAH07_15405 ENOG4107S9D Alpha beta hydrolase CAH07_15410 ENOG4105MYW Pentapeptide repeat protein CAH07_15415 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CAH07_15420 ENOG4108ZUB Lysine exporter protein (Lyse ygga) CAH07_15425 ENOG4105SF0 DinB family CAH07_15430 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) CAH07_15435 ENOG4105ETE Transcriptional regulator (LacI family CAH07_15440 ENOG4106HBX Transcriptional Regulator AraC Family CAH07_15445 ENOG4105UQX Mate efflux family protein CAH07_15460 ENOG4105CAQ asparagine synthetase CAH07_15470 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CAH07_15480 ENOG4105ERH Fumarylacetoacetate hydrolase CAH07_15530 ENOG4105EYH Exonuclease CAH07_15540 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation CAH07_15555 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding CAH07_15560 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) CAH07_15565 ENOG4106K7D Major facilitator family transporter CAH07_15570 ENOG4108KK1 membrane protein AbrB duplication CAH07_15585 ENOG4105TRI Hydrolase CAH07_15600 ENOG4108INS Transcriptional regulator CAH07_15605 ENOG4107SCK Monooxygenase CAH07_15620 ENOG41060YP CAH07_15625 ENOG4106CAD Protein of unknown function (DUF3311) CAH07_15630 ENOG4105E1V na solute symporter CAH07_15635 ENOG4105X3H Excalibur domain protein CAH07_15640 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CAH07_15645 ENOG4105XVF Competence transcription factor CAH07_15665 ENOG4106YBV Methyl-accepting chemotaxis CAH07_15670 ENOG4107ZYJ bioY protein CAH07_15675 ENOG4107F3J Amp-dependent synthetase and ligase CAH07_15685 ENOG4107TB6 phosphoglycerate mutase CAH07_15690 ENOG4108HUF Transporter CAH07_15700 ENOG4105KD7 acetyltransferase CAH07_15710 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 CAH07_15720 ENOG4105CEY Amp-dependent synthetase and ligase CAH07_15730 ENOG4105DF9 Lipoate-protein, ligase CAH07_15735 ENOG4108RQ5 Beta-lactamase domain-containing protein CAH07_15740 ENOG4106AXD CAH07_15755 ENOG4105DER m42 family CAH07_15765 ENOG41090T1 Membrane CAH07_15775 ENOG4105ECB domain protein CAH07_15785 ENOG4105C1Q protoporphyrinogen oxidase CAH07_15790 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) CAH07_15795 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) CAH07_15800 ENOG4105BZ4 penicillin-binding protein CAH07_15805 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation CAH07_15840 ENOG4105K59 histidine triad (HIT) protein CAH07_15845 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) CAH07_15850 ENOG4105NBU tryptophan transport protein CAH07_15895 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) CAH07_15905 ENOG4105EQI Metal Dependent Phosphohydrolase CAH07_15910 ENOG4106D4I domain protein CAH07_15915 ENOG4107VRP DNA repair exonuclease CAH07_15920 ENOG4105RHA ABC transporter, permease CAH07_15925 ENOG4108IUX (ABC) transporter CAH07_15935 ENOG4105CGU Enoyl-CoA hydratase CAH07_15945 ENOG4105NCW Trka-c domain protein CAH07_15950 ENOG4107S91 Sodium hydrogen exchanger CAH07_15955 ENOG4105D4P Coproporphyrinogen iii oxidase CAH07_15965 ENOG4105F1N DNA alkylation repair CAH07_15970 ENOG4105WZB UPF0342 protein CAH07_15975 ENOG4106MP8 UPF0754 membrane protein CAH07_15985 ENOG410839P CAH07_16010 ENOG4105BZ1 (ABC) transporter CAH07_16015 ENOG4105BZ1 (ABC) transporter CAH07_16035 ENOG4105F0I Aminotransferase CAH07_16040 ENOG4107VMI polysaccharide deacetylase CAH07_16045 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) CAH07_16050 ENOG4105D64 Mechanosensitive ion channel CAH07_16060 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CAH07_16065 ENOG4105WMR Protein CrcB homolog CAH07_16075 ENOG4105C37 (CBS) domain CAH07_16080 ENOG4105CHM Aminotransferase CAH07_16090 ENOG4105C37 (CBS) domain CAH07_16095 ENOG4105F6E Acyl-transferase CAH07_16100 ENOG4108FN7 Aldo keto reductase CAH07_16105 ENOG4108AEY RNA polymerase sigma factor CAH07_16110 ENOG4105J37 CAH07_16125 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CAH07_16130 ENOG4105C8J )-transporter CAH07_16135 ENOG4105CUB amino acid CAH07_16140 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CAH07_16145 ENOG4105BZN citrate synthase CAH07_16160 ENOG4105G6Z alkaline phosphatase CAH07_16165 ENOG4105ED1 spovr family CAH07_16200 ENOG4105WH1 Two component transcriptional regulator luxr family CAH07_16205 ENOG4105BZU Histidine kinase CAH07_16215 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CAH07_16220 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CAH07_16230 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator CAH07_16235 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CAH07_16240 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase CAH07_16245 ENOG4107YBY Hydrolase CAH07_16250 ENOG41080XP Cbs domain CAH07_16260 ENOG4108YBP pseudouridine synthase CAH07_16300 ENOG4105BZU Histidine kinase CAH07_16315 ENOG4105VEQ Cold shock protein CAH07_16320 ENOG4108TU7 Inherit from COG: (ABC) transporter CAH07_16325 ENOG4105CJ1 ABC, transporter CAH07_16330 ENOG4105CZV ABC transporter CAH07_16335 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family CAH07_16355 ENOG4105CS1 NAD(P)H quinone oxidoreductase CAH07_16360 ENOG4105C0R drug resistance transporter emrb qaca subfamily CAH07_16365 ENOG4105CW7 secretion protein, HlyD family CAH07_16370 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes CAH07_16375 ENOG4106AKX UPF0229 protein CAH07_16380 ENOG4105CYN Serine protein kinase CAH07_16400 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CAH07_16410 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) CAH07_16425 ENOG4105VZ8 Transcriptional regulator CAH07_16430 ENOG4107D63 CAH07_16435 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) CAH07_16445 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) CAH07_16450 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component CAH07_16455 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein CAH07_16460 ENOG4105E2Y ABC, transporter CAH07_16475 ENOG4105DNP FAD linked oxidase domain protein CAH07_16480 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) CAH07_16485 ENOG4105EC3 peptidase S51, dipeptidase E CAH07_16500 ENOG4108N23 SpoOM-related protein CAH07_16610 ENOG4105G5W regulator Fur family CAH07_16615 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen CAH07_16625 ENOG4107NBY Membrane CAH07_16630 ENOG4105BZ1 (ABC) transporter CAH07_16635 ENOG4105EVI UPF0374 protein CAH07_16650 ENOG4105CAN Short-chain dehydrogenase reductase Sdr CAH07_16655 ENOG4106BXE CAH07_16660 ENOG4105CEN a g-specific adenine glycosylase CAH07_16665 ENOG41067AE Membrane-bound metal-dependent hydrolase CAH07_16670 ENOG4105EJV Membrane CAH07_16675 ENOG4105CKK Glycosyl transferase, family 2 CAH07_16680 ENOG4105D74 hydrolase CAH07_16685 ENOG4106AKJ CAH07_16705 ENOG4105F27 Major Facilitator CAH07_16720 ENOG4105ECP epimerase CAH07_16735 ENOG4107Y03 Nitroreductase CAH07_16740 ENOG4105JAB phenazine biosynthesis protein, phzf family CAH07_16745 ENOG4108IHU transport system permease protein CAH07_16750 ENOG4105DQ5 transport system permease protein CAH07_16755 ENOG4108MES Periplasmic binding protein CAH07_16765 ENOG410834F Transcriptional regulator CAH07_16770 ENOG4105C0R drug resistance transporter emrb qaca subfamily CAH07_16775 ENOG4108YYS metal-dependent hydrolase (By similarity) CAH07_16780 ENOG4105H93 Acyltransferase family CAH07_16785 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold CAH07_16790 ENOG4105U3E Transcriptional regulator CAH07_16795 ENOG4108KYE ABC-2 type transporter CAH07_16800 ENOG41090VJ ABC-2 type transporter CAH07_16805 ENOG4105CJ1 ABC, transporter CAH07_16810 ENOG4105WH1 Two component transcriptional regulator luxr family CAH07_16815 ENOG4105BZU Histidine kinase CAH07_16820 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase CAH07_16830 ENOG4105BZ1 (ABC) transporter CAH07_16835 ENOG4105BZ1 (ABC) transporter CAH07_16840 ENOG4105CI1 PTS System CAH07_16845 ENOG4108Q3X Transcriptional regulator CAH07_16850 ENOG4105F8D glycoside hydrolase family 4 CAH07_16880 ENOG4105KK4 UPF0060 membrane protein CAH07_16885 ENOG41069DP small acid-soluble spore protein CAH07_16890 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family CAH07_16900 ENOG4107QKR Dehydrogenase CAH07_16910 ENOG4107RUY (E1 component), alpha subunit CAH07_16935 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CAH07_16945 ENOG4105D7N magnesium and cobalt transport protein CorA CAH07_16950 ENOG4106KE4 Dehydrogenase CAH07_16970 ENOG4105D8X mechanosensitive ion channel CAH07_16980 ENOG4105UPD Calcium Proton CAH07_16985 ENOG4108ISG Major Facilitator CAH07_16990 ENOG4107U9T Pfam:Ribonuclease_BN CAH07_17000 ENOG4105KJF protein tyrosine phosphatase CAH07_17015 ENOG4107RKG DJ-1/PfpI family CAH07_17020 ENOG4105CGH 5'-nucleotidase CAH07_17025 ENOG4108RCM Nitroreductase CAH07_17030 ENOG4107414 GntR family transcriptional regulator CAH07_17035 ENOG4105CG3 alpha amylase, catalytic region CAH07_17040 ENOG4105C5Y PTS System CAH07_17045 ENOG4105E1K spore germination protein CAH07_17050 ENOG4108Q5U germination protein, ger(x)c family CAH07_17060 ENOG4105GEU Spore germination protein CAH07_17090 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) CAH07_17110 ENOG4108RPX mosc domain containing protein CAH07_17115 ENOG410855V Acylphosphatase CAH07_17140 ENOG4108MRH transcriptional regulatory protein CAH07_17150 ENOG4107QPK )-transporter CAH07_17155 ENOG4108J20 pectate lyase CAH07_17175 ENOG4108HUF Transporter CAH07_17180 ENOG4105DQ5 transport system permease protein CAH07_17185 ENOG4108U1V ABC transporter, permease CAH07_17190 ENOG4105E0A ABC, transporter CAH07_17195 ENOG4105E6M Sulphatase-modifying factor protein CAH07_17210 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein CAH07_17220 ENOG4105FDU atp-dependent rna helicase CAH07_17225 ENOG4105C5H ABC transporter CAH07_17240 ENOG4105DXB Major Facilitator superfamily CAH07_17245 ENOG4107SWG transcriptional regulator MERR family CAH07_17255 ENOG4105C5H ABC transporter CAH07_17260 ENOG4105FKZ Methyl-accepting chemotaxis CAH07_17265 ENOG4105C26 Dehydrogenase CAH07_17270 ENOG4105CUB amino acid CAH07_17280 ENOG4105EU0 Major facilitator Superfamily CAH07_17285 ENOG41090R9 glycosyltransferase CAH07_17290 ENOG4107R51 Glycosyl transferase, family 2 CAH07_17295 ENOG41090R9 glycosyltransferase CAH07_17305 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase CAH07_17310 ENOG4105E0M Sulfatase CAH07_17315 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) CAH07_17320 ENOG4108R1P CAH07_17340 ENOG41061H0 Monooxygenase CAH07_17345 ENOG4106I4J membrane CAH07_17365 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily CAH07_17370 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) CAH07_17375 ENOG4105H67 Protein of unknown function (DUF421) CAH07_17380 ENOG4105F8D glycoside hydrolase family 4 CAH07_17385 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component CAH07_17395 ENOG4105E0S extracellular solute-binding protein family 1 CAH07_17400 ENOG4105EKC CAH07_17410 ENOG4107TDE lipolytic protein G-D-S-L family CAH07_17415 ENOG4105CX8 fg-gap repeat protein CAH07_17420 ENOG4105CX8 fg-gap repeat protein CAH07_17435 ENOG4107TDE lipolytic protein G-D-S-L family CAH07_17440 ENOG41075H3 AraC family transcriptional regulator CAH07_17445 ENOG4105F5H Glycosyl Hydrolase Family 88 CAH07_17450 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component CAH07_17455 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component CAH07_17460 ENOG410769Z extracellular solute-binding protein family 1 CAH07_17465 ENOG4105EQD regulatoR CAH07_17470 ENOG4105C2F Histidine kinase CAH07_17485 ENOG4105M18 -acetyltransferase CAH07_17490 ENOG4105WEF catalase CAH07_17510 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein CAH07_17515 ENOG4105M4P Tetr family transcriptional regulator CAH07_17525 ENOG4105CDY transcriptional regulatory protein CAH07_17595 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) CAH07_17600 ENOG4105CBD Diacylglycerol kinase CAH07_17615 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CAH07_17620 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) CAH07_17625 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) CAH07_17630 ENOG4105CK7 Sodium proline symporter CAH07_17635 ENOG4105KT7 mgtC SapB transporter CAH07_17640 ENOG4105CRN Aminoglycoside phosphotransferase CAH07_17650 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) CAH07_17655 ENOG4105C4R Atp-dependent dna helicase CAH07_17660 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) CAH07_17665 ENOG4105CBC glutamate synthase CAH07_17670 ENOG4105KGF protein, YerC YecD CAH07_17675 ENOG4108R5T secreted protein CAH07_17690 ENOG4105DVH amino acid CAH07_17700 ENOG4105C12 Phosphoribosylglycinamide synthetase CAH07_17705 ENOG4105DC1 bifunctional purine biosynthesis protein purh CAH07_17710 ENOG4108V3E phosphoribosylglycinamide formyltransferase CAH07_17715 ENOG4105CXB phosphoribosylaminoimidazole synthetase CAH07_17725 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii CAH07_17730 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I CAH07_17735 ENOG4105VR9 phosphoribosylformylglycinamidine synthase CAH07_17740 ENOG4105C8V SAICAR synthetase CAH07_17745 ENOG4105C83 adenylosuccinate lyase CAH07_17750 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit CAH07_17755 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) CAH07_17780 ENOG4105C7N Xanthine uracil vitamin C permease CAH07_17810 ENOG4105C7R Atpase associated with various cellular activities aaa_3 CAH07_17825 ENOG4105C85 amino acid CAH07_17830 ENOG4107STQ Multicopper oxidase CAH07_17840 ENOG4107YUH hydrolase CAH07_17870 ENOG4107QNK )-transporter CAH07_17875 ENOG4108ZMR Ion transport 2 domain-containing protein CAH07_17885 ENOG4108WV1 Pfam:DUF477 CAH07_17890 ENOG4105DQX Zinc finger domain CAH07_17895 ENOG41087YS Phage shock protein A CAH07_17905 ENOG4105CT4 transporter CAH07_17910 ENOG4105CPQ Dehydrogenase CAH07_17915 ENOG4105PGZ NB-ARC domain CAH07_17930 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) CAH07_17935 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) CAH07_17940 ENOG4108TYN CAAX amino terminal protease family protein CAH07_17955 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CAH07_17960 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CAH07_17965 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) CAH07_17970 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CAH07_17975 ENOG4105C5H ABC transporter CAH07_17980 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) CAH07_17985 ENOG410801F ribosomal-protein-alanine acetyltransferase CAH07_17990 ENOG41072GX Peptidase M22 Glycoprotease CAH07_17995 ENOG4105K8N protein family UPF0079, ATPase CAH07_18000 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) CAH07_18045 ENOG4105D3P Mannan endo-1,4-beta-mannosidase CAH07_18050 ENOG4105DG6 mannose-6-phosphate isomerase CAH07_18055 ENOG4105EVU fructokinase CAH07_18060 ENOG4108TZY GntR Family Transcriptional Regulator CAH07_18065 ENOG4105CS2 ec 3.2.1.21 CAH07_18070 ENOG4105CK1 PTS System CAH07_18075 ENOG4105VCP PTS System CAH07_18080 ENOG4105VZJ PTS System CAH07_18085 ENOG4105F27 Major Facilitator CAH07_18090 ENOG41090UD (LipO)protein CAH07_18095 ENOG4107TVP HD domain protein CAH07_18100 ENOG4108YM7 Gcn5-related n-acetyltransferase CAH07_18110 ENOG4108ZMX Domain of unknown function (DU1801) CAH07_18115 ENOG4105G6Z alkaline phosphatase CAH07_18130 ENOG4105VRS hydrolase family 18 CAH07_18135 ENOG4105DRR Transcriptional regulator, GntR family CAH07_18145 ENOG4105C2C drug resistance transporter, Bcr CflA CAH07_18150 ENOG4105FS7 Transcriptional regulator CAH07_18155 ENOG4108TVJ Nitroreductase CAH07_18160 ENOG4105EYF MMPL domain protein CAH07_18165 ENOG41062A4 Transcriptional regulator CAH07_18175 ENOG4105C85 amino acid CAH07_18185 ENOG4105WQG acetyltransferase CAH07_18195 ENOG4105PF9 Transcriptional regulator CAH07_18215 ENOG4108QY0 Membrane CAH07_18220 ENOG410900G Protein of unknown function (DUF421) CAH07_18240 ENOG4105XXY Thioredoxin CAH07_18245 ENOG4108VGI doxx family CAH07_18250 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase CAH07_18255 ENOG4108TVJ Nitroreductase CAH07_18260 ENOG41076HS cation diffusion facilitator family transporter CAH07_18265 ENOG4108Z5V transcriptional regulator, merr family CAH07_18270 ENOG4108UQV Membrane CAH07_18275 ENOG4108WC5 Alpha Beta Hydrolase Fold protein CAH07_18280 ENOG4105EYF MMPL domain protein CAH07_18285 ENOG4108VB1 regulatoR CAH07_18290 ENOG4105ENE Histidine kinase CAH07_18305 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) CAH07_18310 ENOG4108ZHR arsR family transcriptional regulator CAH07_18315 ENOG4108SQ9 flavin reductase domain protein, FMN-binding CAH07_18325 ENOG4107Y9U Membrane CAH07_18330 ENOG4105Z7P Acetyltransferase (GNAT) family CAH07_18340 ENOG4107R5R arsenical pump membrane protein CAH07_18345 ENOG41082YX Transcriptional regulator, arsr family CAH07_18350 ENOG4108JGH Tetr family transcriptional regulator CAH07_18355 ENOG4105EQ0 Major Facilitator superfamily CAH07_18360 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein CAH07_18365 ENOG4105KVH Transcriptional regulator CAH07_18375 ENOG4107Z6X Transcriptional regulator CAH07_18380 ENOG4105MJ9 esterase CAH07_18385 ENOG4108ZMQ domain protein CAH07_18390 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CAH07_18395 ENOG4105T38 integral membrane protein CAH07_18400 ENOG4105ST3 Transcriptional regulator CAH07_18405 ENOG4105KRI phosphocarrier protein (HPr CAH07_18415 ENOG4105GIG CAH07_18420 ENOG4105CZ9 Domain of unknown function (DU1801) CAH07_18430 ENOG4105DXI Major Facilitator superfamily CAH07_18435 ENOG4107U9B transcriptional regulator CAH07_18440 ENOG41086D8 Transcriptional regulator CAH07_18445 ENOG4108UZ3 Transporter CAH07_18450 ENOG4108MCI Transcriptional regulator, ARAC family CAH07_18465 ENOG4108VJ1 Transcriptional regulator (CarD family CAH07_18470 ENOG4105VEQ Cold shock protein CAH07_18475 ENOG4105ECK Fatty Acid Desaturase CAH07_18485 ENOG4105VZ8 Transcriptional regulator CAH07_18500 ENOG4105BZ1 (ABC) transporter CAH07_18505 ENOG4105CJA serine threonine protein kinase CAH07_18515 ENOG4105CJA serine threonine protein kinase CAH07_18580 ENOG41064BQ Phosphatase CAH07_18590 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) CAH07_18595 ENOG4105WN5 stage II sporulation protein CAH07_18600 ENOG4107SGM protein serine threonine phosphatase CAH07_18605 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase CAH07_18610 ENOG4105FUA antagonist CAH07_18615 ENOG4107MMM Anti-sigma-factor antagonist CAH07_18620 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) CAH07_18630 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CAH07_18635 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein CAH07_18640 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) CAH07_18650 ENOG4105CKV Membrane CAH07_18655 ENOG410905X membrane-flanked domain protein CAH07_18660 ENOG4105C1J atp-dependent rna helicase CAH07_18670 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) CAH07_18675 ENOG4105CPF Cell wall formation (By similarity) CAH07_18680 ENOG4105SZ6 Thioredoxin CAH07_18700 ENOG4105FDT acyl-CoA dehydrogenase CAH07_18715 ENOG4105CJ1 ABC, transporter CAH07_18720 ENOG4106F5Q Membrane CAH07_18725 ENOG4107QJT sodium dicarboxylate symporter CAH07_18730 ENOG4108MRH transcriptional regulatory protein CAH07_18735 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism CAH07_18740 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit CAH07_18755 ENOG41082W1 Cupin 2, conserved barrel domain protein CAH07_18760 ENOG4105QVS general stress protein CAH07_18765 ENOG4105EU9 CAH07_18770 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) CAH07_18780 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) CAH07_18800 ENOG4105C0X amino acid CAH07_18810 ENOG4107R8N Glycosyl transferase, family 2 CAH07_18815 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) CAH07_18830 ENOG4105C9U ATP-dependent DNA helicase RecQ CAH07_18840 ENOG4105VCH membrane CAH07_18850 ENOG410606W general stress protein CAH07_18865 ENOG4105CYX Short-chain dehydrogenase reductase Sdr CAH07_18870 ENOG4105HMZ Methyltransferase CAH07_18880 ENOG4105ETD TRANSCRIPTIONal CAH07_18885 ENOG4107QM2 Aldo Keto reductase CAH07_18890 ENOG4107RVG penicillin-binding protein CAH07_18895 ENOG41061CK Antibiotic biosynthesis monooxygenase CAH07_18905 ENOG4105XJB lipolytic protein G-D-S-L family CAH07_18910 ENOG4107258 Transcriptional regulator CAH07_18920 ENOG4105P4J Allophanate hydrolase, subunit 1 CAH07_18925 ENOG4105CFM UPF0317 protein CAH07_18930 ENOG4105C5A transporter CAH07_18935 ENOG4105E7W lamb ycsf family protein CAH07_18960 ENOG4108ZX0 Signal peptidase I CAH07_18965 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CAH07_18990 ENOG4108ZYE Transcriptional regulator CAH07_18995 ENOG4108T5E Copper resistance protein CAH07_19000 ENOG4105KTB nuclear export factor GLE1 CAH07_19005 ENOG4105H9W Short-chain dehydrogenase reductase Sdr CAH07_19015 ENOG4105C26 Dehydrogenase CAH07_19020 ENOG4108JPW Aminotransferase CAH07_19030 ENOG4105YVS arsR family transcriptional regulator CAH07_19035 ENOG41067V3 Antibiotic biosynthesis monooxygenase CAH07_19040 ENOG4108DBC nitroreductase CAH07_19045 ENOG4105R8C Transcriptional regulator CAH07_19060 ENOG4108IPW abc transporter atp-binding protein CAH07_19065 ENOG4105CM4 permease protein CAH07_19070 ENOG4105DHS permease protein CAH07_19075 ENOG4105CFH Aspartokinase CAH07_19100 ENOG4105BZU Histidine kinase CAH07_19105 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CAH07_19110 ENOG4107WD8 ABC transporter, permease CAH07_19130 ENOG4105E1K spore germination protein CAH07_19145 ENOG4105DUX Transporter CAH07_19155 ENOG41069ZX CAH07_19160 ENOG41069ZX CAH07_19165 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) CAH07_19170 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase CAH07_19175 ENOG4106P55 Transcriptional regulator CAH07_19185 ENOG4105DRP amino acid AbC transporter CAH07_19190 ENOG4105CDA abc transporter atp-binding protein CAH07_19200 ENOG4105W8Z 4'-phosphopantetheinyl transferase CAH07_19210 ENOG4105SX7 Transporter CAH07_19240 ENOG4105CEY Amp-dependent synthetase and ligase CAH07_19245 ENOG4105KVH Transcriptional regulator CAH07_19250 ENOG4108VA3 3-hexulose-6-phosphate synthase CAH07_19255 ENOG41080HJ 6-phospho 3-hexuloisomerase CAH07_19260 ENOG4105C8Q Methyl-accepting chemotaxis CAH07_19275 ENOG4105CS2 ec 3.2.1.21 CAH07_19285 ENOG4105HHM rdd domain containing protein CAH07_19290 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein CAH07_19295 ENOG4105E5Q amino acid AbC transporter CAH07_19300 ENOG4105CKI cobalamin synthesis protein CAH07_19310 ENOG4105S7A ErfK ybiS ycfS ynhG family protein CAH07_19330 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) CAH07_19335 ENOG4108IFG nitrite reductase, (NAD(P)H) CAH07_19340 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit CAH07_19345 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CAH07_19355 ENOG4105U6C Alpha beta hydrolase fold protein CAH07_19360 ENOG4108PJD permease CAH07_19370 ENOG4107YHD transcriptional regulator CAH07_19375 ENOG4105CK7 Sodium proline symporter CAH07_19380 ENOG4105C26 Dehydrogenase CAH07_19390 ENOG410756H nucleotidyltransferase CAH07_19395 ENOG4105I82 acetyl xylan esterase CAH07_19400 ENOG4105C5Q Transcriptional regulator CAH07_19405 ENOG41089UC methyltransferase, type 11 CAH07_19410 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) CAH07_19415 ENOG4105I1F Resistance protein CAH07_19420 ENOG4107RA1 nh(3)-dependent nad( ) synthetase CAH07_19425 ENOG4105EIG urea carboxylase-associated protein 1 CAH07_19460 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CAH07_19490 ENOG4107SQ8 Glycine betaine CAH07_19495 ENOG4108IJ7 Glycine betaine CAH07_19500 ENOG4108A65 Transcriptional regulator CAH07_19505 ENOG4107XZQ multidrug resistance protein CAH07_19515 ENOG41079KZ Major Facilitator Superfamily CAH07_19525 ENOG4108TTB tellurium resistance protein CAH07_19530 ENOG4107TS3 membrane protein, TerC CAH07_19535 ENOG4106FN3 tellurium resistance protein CAH07_19540 ENOG4106FN3 tellurium resistance protein CAH07_19545 ENOG4108N0M stress protein CAH07_19550 ENOG4105DEN Luciferase family CAH07_19560 ENOG4105DIK (ABC) transporter CAH07_19565 ENOG4105DSE periplasmic solute binding protein CAH07_19575 ENOG4105H9W Short-chain dehydrogenase reductase Sdr CAH07_19615 ENOG4108SDH ABC, transporter CAH07_19620 ENOG4108IUW ABC transporter CAH07_19625 ENOG4107Y7X LytTR CAH07_19635 ENOG41060AI SEC-C motif CAH07_19645 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold CAH07_19650 ENOG4107RB3 L-asparaginase CAH07_19655 ENOG4105J7D transcriptional regulator CAH07_19660 ENOG4105C0R drug resistance transporter emrb qaca subfamily CAH07_19665 ENOG4107EPV Aminotransferase class V CAH07_19670 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) CAH07_19675 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CAH07_19680 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) CAH07_19685 ENOG4105DGI Alkaline phosphatase CAH07_19695 ENOG4105MUA Resistance protein CAH07_19725 ENOG4105DPZ Two component transcriptional regulator (Winged helix family CAH07_19745 ENOG4105CTX dehydratase CAH07_19750 ENOG41073TP transcriptional regulator CAH07_19755 ENOG4105EQX glucarate dehydratase CAH07_19760 ENOG4105DJB Major Facilitator Superfamily CAH07_19765 ENOG4105C26 Dehydrogenase CAH07_19770 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase CAH07_19790 ENOG4105CSV Glutaminase CAH07_19805 ENOG4108J5H Homocysteine s-methyltransferase CAH07_19810 ENOG4108IQI permease CAH07_19815 ENOG4105CM2 brancheD-chain amino acid aminotransferase CAH07_19825 ENOG4108X79 transcriptional regulator CAH07_19830 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) CAH07_19835 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane CAH07_19845 ENOG4105C72 UPF0176 protein CAH07_19860 ENOG4107ZTW SNARE associated Golgi CAH07_19865 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase CAH07_19870 ENOG4108WC5 Alpha Beta Hydrolase Fold protein CAH07_19880 ENOG4108TCS Glutamyl endopeptidase CAH07_19885 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR CAH07_19890 ENOG4106AXJ AraC family transcriptional regulator CAH07_19895 ENOG410631K Membrane CAH07_19910 ENOG4105DCM major facilitator superfamily CAH07_19915 ENOG410645S MarR family Transcriptional regulator CAH07_19930 ENOG4105CXY transporter CAH07_19935 ENOG4107VXM glycerophosphoryl diester phosphodiesterase CAH07_19940 ENOG4107QTZ amino acid CAH07_19950 ENOG4107E6A Cytochrome p-450 CAH07_19965 ENOG4106DDH Sporulation-specific SASP protein CAH07_19975 ENOG4106K80 CAH07_19985 ENOG4105G0J serine threonine protein kinase CAH07_20020 ENOG4108RWP Major Facilitator Superfamily protein CAH07_20025 ENOG4105WAB arsR family transcriptional regulator CAH07_20030 ENOG4105GPN Uncharacterized conserved protein (DUF2294) CAH07_20050 ENOG4108TWJ NADH dehydrogenase subunit 5 CAH07_20055 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CAH07_20065 ENOG4105D03 DNA-3-methyladenine glycosylase II CAH07_20075 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) CAH07_20080 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) CAH07_20085 ENOG4107U5W ybbr family CAH07_20090 ENOG4105C8B TIGR00159 family CAH07_20100 ENOG4105EMN RNA polymerase sigma factor CAH07_20130 ENOG4105EWC Purine nucleoside phosphorylase CAH07_20140 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate CAH07_20160 ENOG4105D17 glycoside hydrolase, family 3 domain protein CAH07_20165 ENOG4105EHZ conserved protein UCP016719 CAH07_20170 ENOG410874W AraC family transcriptional regulator CAH07_20190 ENOG4108SA1 esterase CAH07_20200 ENOG4105CHH sulfate transporter CAH07_20375 ENOG4108NMV polysaccharide deacetylase CAH07_20390 ENOG4105D1F ATP-binding protein CAH07_20405 ENOG4108I0C methyltransferase CAH07_20410 ENOG4108UJD 30S ribosomal protein S9 CAH07_20415 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) CAH07_20420 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) CAH07_20425 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) CAH07_20430 ENOG4108JJB ABC transporter CAH07_20435 ENOG4108JJB ABC transporter CAH07_20440 ENOG4108ZT0 50S ribosomal protein l17 CAH07_20445 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CAH07_20450 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) CAH07_20455 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits CAH07_20465 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) CAH07_20475 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) CAH07_20485 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CAH07_20490 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) CAH07_20495 ENOG4105VPB 50S ribosomal protein L30 CAH07_20500 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) CAH07_20505 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) CAH07_20510 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) CAH07_20515 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) CAH07_20525 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits CAH07_20535 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) CAH07_20540 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal CAH07_20545 ENOG41082SA 50s ribosomal protein l29 CAH07_20550 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) CAH07_20555 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) CAH07_20560 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) CAH07_20565 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) CAH07_20570 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity CAH07_20575 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) CAH07_20580 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) CAH07_20585 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) CAH07_20590 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) CAH07_20595 ENOG4107SKW Inherit from COG: Alpha beta hydrolase CAH07_20600 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) CAH07_20605 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) CAH07_20610 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) CAH07_20615 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) CAH07_20620 ENOG4105XPM ribosomal protein CAH07_20625 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CAH07_20630 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) CAH07_20635 ENOG4107Y49 methyltransferase CAH07_20640 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) CAH07_20645 ENOG4108VZM 50s ribosomal protein L10 CAH07_20655 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) CAH07_20660 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) CAH07_20680 ENOG4105M0M Tetracycline resistance protein CAH07_20685 ENOG4105C2N RNA methyltransferase TrmH family group 3 CAH07_20690 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) CAH07_20695 ENOG4105C8N cysteinyl-tRNA synthetase CAH07_20700 ENOG4105D7W serine acetyltransferase CAH07_20710 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) CAH07_20715 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) CAH07_20720 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) CAH07_20725 ENOG4105CTP PilT protein domain protein CAH07_20730 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) CAH07_20735 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CAH07_20745 ENOG41066A3 ATP guanido phosphotransferase CAH07_20750 ENOG4108Z0C Uvrb UvrC protein CAH07_20835 ENOG4105CRK lysyL-tRNA synthetase CAH07_20840 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) CAH07_20850 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase CAH07_20855 ENOG4105KRF dihydroneopterin aldolase CAH07_20860 ENOG4105EEI dihydropteroate synthase CAH07_20865 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 CAH07_20870 ENOG4105DDQ anthranilate synthase CAH07_20875 ENOG4105CRQ synthase (Component I) CAH07_20880 ENOG4105C6T cysteine synthase CAH07_20885 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase CAH07_20890 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) CAH07_20900 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CAH07_20905 ENOG4108UGV hypoxanthine phosphoribosyltransferase CAH07_20910 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) CAH07_20940 ENOG41060GV RNA binding s1 domain protein CAH07_20955 ENOG4105VYY sporulation protein yabp CAH07_20960 ENOG41082I2 s4 domain protein CAH07_20965 ENOG4108IY2 MazG family CAH07_20975 ENOG4108M14 stage v sporulation protein t CAH07_20980 ENOG4108JA2 transcriptioN-repair coupling factor CAH07_20990 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CAH07_20995 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) CAH07_21000 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CAH07_21005 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CAH07_21010 ENOG4105K4W Could be involved in septation (By similarity) CAH07_21015 ENOG4105KME endoribonuclease L-psp CAH07_21020 ENOG4105DFT pur operon repressor CAH07_21025 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) CAH07_21030 ENOG4105XEW small acid-soluble spore protein CAH07_21035 ENOG4105W42 Veg protein CAH07_21040 ENOG4105XFA sporulation peptidase YabG CAH07_21045 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) CAH07_21055 ENOG41069ER domain protein CAH07_21060 ENOG4105F8V Hydrolase, tatD family CAH07_21065 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) CAH07_21070 ENOG4105KRN Transcriptional regulator, abrb family CAH07_21075 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) CAH07_21080 ENOG4105VC4 domain protein CAH07_21085 ENOG41060K3 Methyltransferase CAH07_21090 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) CAH07_21095 ENOG4105MA4 psp1 domain protein CAH07_21100 ENOG4105FA2 dna polymerase iii CAH07_21105 ENOG4105XVJ Protein of unknown function (DUF327) CAH07_21110 ENOG4105X0R protein from nitrogen regulatory protein P-II CAH07_21115 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) CAH07_21120 ENOG4105CXN decarboxylase CAH07_21125 ENOG4105CDW Resistance protein CAH07_21165 ENOG41067KS pro-sigma K processing CAH07_21175 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) CAH07_21180 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) CAH07_21185 ENOG4105C6E dna polymerase iii CAH07_21195 ENOG4108Z6B deaminase CAH07_21200 ENOG4105GTG Isochorismatase CAH07_21205 ENOG4105VRS hydrolase family 18 CAH07_21215 ENOG4105ZMH deoxynucleoside kinase CAH07_21225 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) CAH07_21230 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) CAH07_21235 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) CAH07_21245 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) CAH07_21280 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CAH07_21285 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CAH07_21300 ENOG410848D S4 domain protein YaaA CAH07_21305 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)