locus-tag	class	description
HWV68_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HWV68_00010	COG0592	DNA-directed DNA polymerase activity
HWV68_00015	COG2501	S4 domain
HWV68_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HWV68_00030	COG0187	DNA topoisomerase II activity
HWV68_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HWV68_00070	COG0517	IMP dehydrogenase activity
HWV68_00070	COG0516	GMP reductase activity
HWV68_00075	COG1686	Belongs to the peptidase S11 family
HWV68_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
HWV68_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
HWV68_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HWV68_00100	COG1428	Deoxynucleoside kinase
HWV68_00105	COG1428	Deoxynucleoside kinase
HWV68_00110	COG1388	LysM domain
HWV68_00110	COG3858	chitin binding
HWV68_00115	COG1335	isochorismatase
HWV68_00120	COG0590	tRNA wobble adenosine to inosine editing
HWV68_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HWV68_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HWV68_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HWV68_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
HWV68_00190	COG3853	Toxic anion resistance protein (TelA)
HWV68_00195	COG1982	Orn Lys Arg decarboxylase major
HWV68_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HWV68_00205	COG3870	Protein conserved in bacteria
HWV68_00210	COG1728	Protein conserved in bacteria
HWV68_00215	COG0470	DNA polymerase III
HWV68_00220	COG1774	PSP1 C-terminal conserved region
HWV68_00225	COG4467	Involved in initiation control of chromosome replication
HWV68_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
HWV68_00235	COG2827	Endonuclease containing a URI domain
HWV68_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HWV68_00245	COG2002	toxin-antitoxin pair type II binding
HWV68_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWV68_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWV68_00255	COG0084	hydrolase, TatD family'
HWV68_00260	COG3584	3D domain protein
HWV68_00260	COG3583	domain protein
HWV68_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HWV68_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HWV68_00280	COG4466	Protein conserved in bacteria
HWV68_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HWV68_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HWV68_00300	COG0251	oxidation-reduction process
HWV68_00305	COG2088	sporulation resulting in formation of a cellular spore
HWV68_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HWV68_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HWV68_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HWV68_00325	COG0193	aminoacyl-tRNA hydrolase activity
HWV68_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HWV68_00340	COG2002	toxin-antitoxin pair type II binding
HWV68_00345	COG2244	polysaccharide biosynthetic process
HWV68_00350	COG3956	TIGRFAM MazG family protein
HWV68_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HWV68_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
HWV68_00375	COG1098	S1 RNA binding domain
HWV68_00390	COG2208	phosphoserine phosphatase activity
HWV68_00395	COG2304	oxidoreductase activity
HWV68_00400	COG0515	serine threonine protein kinase
HWV68_00405	COG0037	tRNA processing
HWV68_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HWV68_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HWV68_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HWV68_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HWV68_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HWV68_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HWV68_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
HWV68_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HWV68_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HWV68_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HWV68_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HWV68_00470	COG1396	sequence-specific DNA binding
HWV68_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HWV68_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HWV68_00560	COG4463	regulation of RNA biosynthetic process
HWV68_00565	COG3880	PFAM UvrB UvrC protein
HWV68_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
HWV68_00575	COG0542	response to heat
HWV68_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HWV68_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
HWV68_00590	COG4956	integral membrane protein (PIN domain superfamily)
HWV68_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HWV68_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HWV68_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HWV68_00610	COG1045	serine acetyltransferase
HWV68_00615	COG0215	cysteine-tRNA ligase activity
HWV68_00620	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
HWV68_00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HWV68_00630	COG3688	RNA-binding protein containing a PIN domain
HWV68_00635	COG1595	DNA-templated transcription, initiation
HWV68_00645	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HWV68_00650	COG0250	Participates in transcription elongation, termination and antitermination
HWV68_00660	COG0081	regulation of translation
HWV68_00665	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HWV68_00675	COG2813	Specifically methylates the guanine in position
HWV68_00680	COG0085	RNA polymerase activity
HWV68_00685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HWV68_00690	COG1358	cellular component organization or biogenesis
HWV68_00695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HWV68_00700	COG0049	tRNA binding
HWV68_00705	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HWV68_00710	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HWV68_00715	COG0596	Alpha beta hydrolase
HWV68_00725	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HWV68_00730	COG0088	Forms part of the polypeptide exit tunnel
HWV68_00740	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HWV68_00755	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HWV68_00760	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HWV68_00770	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HWV68_00775	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HWV68_00785	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HWV68_00795	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HWV68_00800	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HWV68_00805	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HWV68_00810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HWV68_00820	COG0200	Binds to the 23S rRNA
HWV68_00825	COG0201	protein transport
HWV68_00830	COG0563	adenylate kinase activity
HWV68_00835	COG0024	Methionine aminopeptidase
HWV68_00850	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HWV68_00855	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HWV68_00860	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HWV68_00865	COG0202	RNA polymerase activity
HWV68_00870	COG0203	ribosomal protein L17
HWV68_00875	COG1122	ATPase activity
HWV68_00880	COG1122	ATPase activity
HWV68_00885	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HWV68_00890	COG0101	tRNA pseudouridine synthase activity
HWV68_00895	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HWV68_00900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HWV68_00905	COG2226	methyltransferase
HWV68_00915	COG0860	N-Acetylmuramoyl-L-alanine amidase
HWV68_00920	COG0489	protein tyrosine kinase activity
HWV68_00930	COG2194	sulfuric ester hydrolase activity
HWV68_00935	COG0726	polysaccharide deacetylase
HWV68_01015	COG0659	secondary active sulfate transmembrane transporter activity
HWV68_01020	COG0385	Bile acid
HWV68_01025	COG2819	hydrolase of the alpha beta superfamily
HWV68_01030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWV68_01035	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWV68_01040	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HWV68_01045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HWV68_01045	COG2207	Transcriptional regulator
HWV68_01050	COG3876	Protein conserved in bacteria
HWV68_01055	COG1472	Belongs to the glycosyl hydrolase 3 family
HWV68_01060	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HWV68_01065	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWV68_01065	COG1263	PTS System
HWV68_01070	COG1737	Transcriptional regulator
HWV68_01075	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
HWV68_01080	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWV68_01085	COG1683	Conserved Protein
HWV68_01115	COG1595	DNA-templated transcription, initiation
HWV68_01120	COG5662	AntiSigma factor
HWV68_01125	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HWV68_01130	COG4856	YbbR-like protein
HWV68_01135	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HWV68_01140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HWV68_01150	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HWV68_01155	COG2169	Transcriptional regulator
HWV68_01160	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HWV68_01165	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HWV68_01170	COG3002	Belongs to the UPF0753 family
HWV68_01175	COG0288	reversible hydration of carbon dioxide
HWV68_01185	COG5609	conserved protein (DUF2294)
HWV68_01190	COG0640	Transcriptional regulator
HWV68_01195	COG2814	Major facilitator Superfamily
HWV68_01210	COG0535	radical SAM domain protein
HWV68_01215	COG1266	CAAX protease self-immunity
HWV68_01220	COG1131	(ABC) transporter
HWV68_01230	COG1413	lyase activity
HWV68_01235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWV68_01240	COG0596	Alpha beta hydrolase
HWV68_01245	COG0745	RESPONSE REGULATOR receiver
HWV68_01250	COG0642	Histidine kinase
HWV68_01260	COG0515	serine threonine protein kinase
HWV68_01275	COG1113	amino acid transport
HWV68_01290	COG2602	Beta-lactamase
HWV68_01295	COG2124	cytochrome p450
HWV68_01305	COG0531	amino acid
HWV68_01310	COG0584	glycerophosphoryl diester phosphodiesterase
HWV68_01315	COG2271	Major facilitator Superfamily
HWV68_01325	COG1846	Transcriptional regulator
HWV68_01325	COG0456	acetyltransferase
HWV68_01330	COG2271	Major facilitator Superfamily
HWV68_01340	COG3409	Peptidoglycan-binding domain 1 protein
HWV68_01345	COG0697	spore germination
HWV68_01350	COG2207	Transcriptional regulator
HWV68_01350	COG1917	Cupin 2, conserved barrel domain protein
HWV68_01355	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HWV68_01360	COG3591	Belongs to the peptidase S1B family
HWV68_01370	COG0596	Alpha beta hydrolase
HWV68_01375	COG1183	phosphatidylcholine synthase activity
HWV68_01380	COG0586	Pfam SNARE associated Golgi protein
HWV68_01385	COG0688	phosphatidylethanolamine metabolic process
HWV68_01395	COG2312	Erythromycin esterase
HWV68_01400	COG2207	Transcriptional regulator
HWV68_01410	COG1301	dicarboxylic acid transport
HWV68_01415	COG2190	(PTS) system
HWV68_01415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWV68_01415	COG1263	PTS System
HWV68_01420	COG0363	glucosamine-6-phosphate deaminase activity
HWV68_01425	COG2188	Transcriptional regulator
HWV68_01435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HWV68_01440	COG0833	amino acid
HWV68_01445	COG2040	homocysteine
HWV68_01450	COG1115	amino acid carrier protein
HWV68_01455	COG2066	Belongs to the glutaminase family
HWV68_01460	COG4191	Histidine kinase
HWV68_01465	COG0784	Response regulator, receiver
HWV68_01470	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWV68_01475	COG1012	belongs to the aldehyde dehydrogenase family
HWV68_01480	COG2271	Major facilitator Superfamily
HWV68_01485	COG4948	Mandelate Racemase Muconate Lactonizing
HWV68_01490	COG2186	Transcriptional regulator
HWV68_01495	COG2721	sulfolactate sulfo-lyase activity
HWV68_01500	COG3173	Aminoglycoside phosphotransferase
HWV68_01510	COG0697	spore germination
HWV68_01515	COG0745	RESPONSE REGULATOR receiver
HWV68_01520	COG2205	protein histidine kinase activity
HWV68_01525	COG1131	(ABC) transporter
HWV68_01545	COG3773	Cell wall hydrolase
HWV68_01550	COG2304	oxidoreductase activity
HWV68_01560	COG3540	Alkaline phosphatase
HWV68_01565	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HWV68_01570	COG0805	protein transport
HWV68_01575	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
HWV68_01580	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HWV68_01585	COG0477	Major facilitator Superfamily
HWV68_01590	COG1309	transcriptional regulator
HWV68_01595	COG0252	asparaginase activity
HWV68_01600	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HWV68_01605	COG1714	RDD family
HWV68_01610	COG3012	SEC-C Motif Domain Protein
HWV68_01610	COG1405	negative regulation of cell septum assembly
HWV68_01615	COG3290	protein histidine kinase activity
HWV68_01620	COG3279	Response regulator of the LytR AlgR family
HWV68_01625	COG4555	ABC transporter
HWV68_01630	COG1668	transmembrane transport
HWV68_01635	COG0667	Aldo Keto reductase
HWV68_01650	COG1595	DNA-templated transcription, initiation
HWV68_01655	COG1595	DNA-templated transcription, initiation
HWV68_01660	COG1876	peptidase activity
HWV68_01665	COG0457	Tetratricopeptide repeat
HWV68_01670	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_01675	COG0366	Alpha amylase catalytic
HWV68_01680	COG0803	Belongs to the bacterial solute-binding protein 9 family
HWV68_01685	COG1121	(ABC) transporter
HWV68_01690	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HWV68_01695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWV68_01700	COG2310	stress, protein
HWV68_01705	COG2310	stress, protein
HWV68_01710	COG2310	stress, protein
HWV68_01715	COG0861	Integral membrane protein TerC family
HWV68_01725	COG3853	Toxic anion resistance protein (TelA)
HWV68_01730	COG0477	Major facilitator Superfamily
HWV68_01735	COG2814	Major facilitator Superfamily
HWV68_01740	COG0640	Transcriptional regulator
HWV68_01745	COG0517	IMP dehydrogenase activity
HWV68_01745	COG4175	Glycine betaine
HWV68_01750	COG4176	ABC-type proline glycine betaine transport system permease component
HWV68_01755	COG2113	Glycine betaine
HWV68_01760	COG1473	amidohydrolase
HWV68_01765	COG1288	antiporter activity
HWV68_01775	COG0366	Alpha amylase catalytic
HWV68_01780	COG0039	L-malate dehydrogenase activity
HWV68_01785	COG1620	l-lactate permease
HWV68_01790	COG2814	Major facilitator Superfamily
HWV68_01795	COG1846	Transcriptional regulator
HWV68_01800	COG1280	lysine exporter protein (LysE YggA)
HWV68_01805	COG3403	YqcI/YcgG family
HWV68_01810	COG1113	amino acid transport
HWV68_01815	COG3665	Urea carboxylase-associated protein
HWV68_01820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HWV68_01825	COG1660	Displays ATPase and GTPase activities
HWV68_01830	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HWV68_01835	COG2226	methyltransferase
HWV68_01840	COG0583	DNA-binding transcription factor activity
HWV68_01845	COG3458	cephalosporin-C deacetylase activity
HWV68_01850	COG3541	Predicted nucleotidyltransferase
HWV68_01855	COG0506	proline dehydrogenase activity
HWV68_01860	COG1012	belongs to the aldehyde dehydrogenase family
HWV68_01865	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWV68_01870	COG2508	Transcriptional regulator
HWV68_01875	COG3689	TIGRFAM TIGR03943 family protein
HWV68_01880	COG0701	Predicted permease
HWV68_01885	COG2267	carboxylic ester hydrolase activity
HWV68_01890	COG0492	ferredoxin-NADP+ reductase activity
HWV68_01895	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HWV68_01895	COG1587	Uroporphyrinogen-III synthase
HWV68_01900	COG2146	nitrite reductase [NAD(P)H] activity
HWV68_01905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWV68_01910	COG0243	molybdopterin cofactor binding
HWV68_01915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWV68_01920	COG2223	nitrite transmembrane transporter activity
HWV68_01925	COG1469	GTP cyclohydrolase I activity
HWV68_01930	COG1376	ErfK ybiS ycfS ynhG family protein
HWV68_01940	COG0523	cobalamin synthesis protein
HWV68_01945	COG0765	amino acid transport
HWV68_01950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWV68_01960	COG1714	RDD family
HWV68_01970	COG2723	6-phospho-beta-galactosidase activity
HWV68_01980	COG3209	COG3209 Rhs family protein
HWV68_01985	COG3290	protein histidine kinase activity
HWV68_01985	COG0840	transmembrane signaling receptor activity
HWV68_01990	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HWV68_01995	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HWV68_02000	COG1733	regulation of RNA biosynthetic process
HWV68_02005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_02010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_02015	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_02020	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
HWV68_02025	COG2814	Major facilitator Superfamily
HWV68_02035	COG0697	spore germination
HWV68_02040	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWV68_02050	COG2364	Membrane
HWV68_02055	COG1126	abc transporter atp-binding protein
HWV68_02060	COG0765	amino acid transport
HWV68_02065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWV68_02070	COG0583	DNA-binding transcription factor activity
HWV68_02075	COG0163	prenyltransferase activity
HWV68_02080	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HWV68_02095	COG0596	Alpha beta hydrolase
HWV68_02100	COG3104	oligopeptide transport
HWV68_02105	COG5434	Belongs to the glycosyl hydrolase 28 family
HWV68_02115	COG0697	spore germination
HWV68_02125	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HWV68_02130	COG1136	(ABC) transporter
HWV68_02135	COG0577	efflux transmembrane transporter activity
HWV68_02140	COG0745	RESPONSE REGULATOR receiver
HWV68_02145	COG5002	protein histidine kinase activity
HWV68_02145	COG3850	Histidine kinase
HWV68_02150	COG0457	Tetratricopeptide repeat
HWV68_02170	COG0527	aspartate kinase activity
HWV68_02175	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWV68_02180	COG4605	iron ion homeostasis
HWV68_02185	COG4604	ABC transporter, ATP-binding protein
HWV68_02190	COG4607	ABC-type enterochelin transport system periplasmic component
HWV68_02195	COG2814	Major facilitator Superfamily
HWV68_02200	COG1309	transcriptional regulator
HWV68_02205	COG0778	Nitroreductase
HWV68_02210	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HWV68_02215	COG0640	Transcriptional regulator
HWV68_02220	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWV68_02225	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HWV68_02230	COG1012	belongs to the aldehyde dehydrogenase family
HWV68_02235	COG4975	Glucose uptake
HWV68_02240	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_02245	COG4549	nuclear export factor GLE1
HWV68_02250	COG1276	copper resistance
HWV68_02250	COG2372	response to copper ion
HWV68_02255	COG1349	DNA-binding transcription factor activity
HWV68_02265	COG2213	PTS system mannitol-specific
HWV68_02270	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWV68_02275	COG0246	Mannitol dehydrogenase
HWV68_02280	COG0473	3-isopropylmalate dehydrogenase activity
HWV68_02285	COG0681	Belongs to the peptidase S26 family
HWV68_02290	COG0412	Dienelactone hydrolase
HWV68_02295	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HWV68_02305	COG0561	phosphatase activity
HWV68_02310	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
HWV68_02315	COG1914	H( )-stimulated, divalent metal cation uptake system
HWV68_02320	COG4336	lyase activity
HWV68_02325	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HWV68_02330	COG1984	allophanate hydrolase subunit 2
HWV68_02335	COG1414	Transcriptional regulator
HWV68_02340	COG2755	lipolytic protein G-D-S-L family
HWV68_02350	COG2329	Antibiotic biosynthesis monooxygenase
HWV68_02355	COG0768	penicillin binding
HWV68_02360	COG4989	oxidoreductase activity
HWV68_02365	COG3711	transcriptional antiterminator
HWV68_02370	COG0318	PFAM AMP-dependent synthetase and ligase
HWV68_02375	COG2226	methyltransferase
HWV68_02380	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_02385	COG1917	Cupin 2, conserved barrel domain protein
HWV68_02390	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWV68_02395	COG3871	stress protein (general stress protein 26)
HWV68_02405	COG2814	Major facilitator Superfamily
HWV68_02410	COG1522	sequence-specific DNA binding
HWV68_02415	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HWV68_02415	COG0551	DNA topoisomerase type I activity
HWV68_02420	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HWV68_02425	COG3706	GGDEF domain
HWV68_02430	COG5298	Protein conserved in bacteria
HWV68_02435	COG1215	transferase activity, transferring glycosyl groups
HWV68_02445	COG0531	amino acid
HWV68_02450	COG0494	nUDIX hydrolase
HWV68_02455	COG0028	Belongs to the TPP enzyme family
HWV68_02470	COG1914	H( )-stimulated, divalent metal cation uptake system
HWV68_02475	COG2261	transglycosylase associated protein
HWV68_02480	COG4876	unkown
HWV68_02485	COG2217	Heavy metal translocating P-type atpase
HWV68_02490	COG3729	General stress protein
HWV68_02495	COG0662	Cupin 2, conserved barrel domain protein
HWV68_02500	COG2329	Antibiotic biosynthesis monooxygenase
HWV68_02505	COG3546	catalase activity
HWV68_02510	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HWV68_02515	COG3290	protein histidine kinase activity
HWV68_02520	COG4565	transcriptional regulatory protein
HWV68_02525	COG1301	dicarboxylic acid transport
HWV68_02530	COG0628	permease
HWV68_02535	COG1131	(ABC) transporter
HWV68_02540	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HWV68_02550	COG1960	acyl-CoA dehydrogenase activity
HWV68_02565	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HWV68_02570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWV68_02575	COG1181	Belongs to the D-alanine--D-alanine ligase family
HWV68_02580	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HWV68_02585	COG0513	Belongs to the DEAD box helicase family
HWV68_02590	COG3402	PFAM membrane-flanked domain
HWV68_02595	COG3428	Bacterial PH domain
HWV68_02600	COG0705	Rhomboid family
HWV68_02605	COG0736	holo-[acyl-carrier-protein] synthase activity
HWV68_02610	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
HWV68_02615	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HWV68_02620	COG0864	Transcriptional regulator
HWV68_02625	COG2337	Toxic component of a toxin-antitoxin (TA) module
HWV68_02630	COG1366	Belongs to the anti-sigma-factor antagonist family
HWV68_02635	COG1366	Belongs to the anti-sigma-factor antagonist family
HWV68_02640	COG2172	sigma factor antagonist activity
HWV68_02645	COG2208	phosphoserine phosphatase activity
HWV68_02650	COG1366	Belongs to the anti-sigma-factor antagonist family
HWV68_02655	COG2172	sigma factor antagonist activity
HWV68_02660	COG1191	sigma factor activity
HWV68_02665	COG2208	phosphoserine phosphatase activity
HWV68_02680	COG1673	EVE domain
HWV68_02685	COG1846	Transcriptional regulator
HWV68_02690	COG2183	response to ionizing radiation
HWV68_02700	COG3091	SprT-like family
HWV68_02740	COG0582	viral genome integration into host DNA
HWV68_02745	COG2856	Zn peptidase
HWV68_02750	COG1396	sequence-specific DNA binding
HWV68_02780	COG1674	ftsk spoiiie
HWV68_02785	COG2946	Replication initiation factor
HWV68_02820	COG0433	COG0433 Predicted ATPase
HWV68_02830	COG5644	endopeptidase inhibitor activity
HWV68_02835	COG0791	NLP P60 protein
HWV68_02835	COG0741	lytic transglycosylase activity
HWV68_02855	COG0457	Tetratricopeptide repeat
HWV68_02870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWV68_02875	COG1522	sequence-specific DNA binding
HWV68_02880	COG1522	sequence-specific DNA binding
HWV68_02885	COG1335	isochorismatase
HWV68_02890	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HWV68_02895	COG2814	Major facilitator Superfamily
HWV68_02915	COG0693	protein deglycase activity
HWV68_02920	COG1278	Cold shock
HWV68_02925	COG1329	Transcriptional regulator
HWV68_02935	COG1917	Cupin 2, conserved barrel domain protein
HWV68_02935	COG2207	Transcriptional regulator
HWV68_02940	COG0697	spore germination
HWV68_02945	COG2207	Transcriptional regulator
HWV68_02945	COG3708	Transcriptional regulator
HWV68_02950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWV68_02955	COG0477	Major facilitator Superfamily
HWV68_02965	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
HWV68_02975	COG0697	spore germination
HWV68_02980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWV68_02985	COG2030	dehydratase
HWV68_02990	COG3545	Serine hydrolase
HWV68_02995	COG1733	regulation of RNA biosynthetic process
HWV68_03000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HWV68_03005	COG1733	regulation of RNA biosynthetic process
HWV68_03010	COG2249	NAD(P)H dehydrogenase (quinone) activity
HWV68_03015	COG2814	Major facilitator Superfamily
HWV68_03020	COG1309	transcriptional regulator
HWV68_03025	COG0640	Transcriptional regulator
HWV68_03030	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HWV68_03040	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWV68_03045	COG0697	spore germination
HWV68_03050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWV68_03055	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HWV68_03060	COG0640	Transcriptional regulator
HWV68_03065	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HWV68_03080	COG4585	Histidine kinase
HWV68_03085	COG2197	response regulator
HWV68_03090	COG2409	Drug exporters of the RND superfamily
HWV68_03095	COG0596	Alpha beta hydrolase
HWV68_03100	COG1811	Na channel or pump
HWV68_03105	COG4978	Transcriptional regulator
HWV68_03105	COG0789	Transcriptional regulator
HWV68_03110	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HWV68_03115	COG0778	Nitroreductase
HWV68_03120	COG0346	lactoylglutathione lyase activity
HWV68_03125	COG2259	Doxx family
HWV68_03130	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWV68_03145	COG2323	membrane
HWV68_03150	COG2323	membrane
HWV68_03155	COG0071	Belongs to the small heat shock protein (HSP20) family
HWV68_03170	COG1309	transcriptional regulator
HWV68_03180	COG0456	acetyltransferase
HWV68_03190	COG1113	amino acid transport
HWV68_03195	COG2318	DinB family
HWV68_03200	COG1846	Transcriptional regulator
HWV68_03205	COG1033	growth of symbiont in host cell
HWV68_03205	COG2409	Drug exporters of the RND superfamily
HWV68_03210	COG0778	Nitroreductase
HWV68_03215	COG1846	Transcriptional regulator
HWV68_03220	COG2814	Major facilitator Superfamily
HWV68_03225	COG0730	response to heat
HWV68_03230	COG1802	Transcriptional regulator
HWV68_03235	COG1388	LysM domain
HWV68_03235	COG3858	chitin binding
HWV68_03240	COG1819	glycosyl
HWV68_03250	COG1785	Belongs to the alkaline phosphatase family
HWV68_03255	COG5646	InterPro IPR014922
HWV68_03265	COG0454	-acetyltransferase
HWV68_03270	COG1078	dGTPase activity
HWV68_03275	COG1388	LysM domain
HWV68_03280	COG2814	Major facilitator Superfamily
HWV68_03285	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HWV68_03290	COG1447	Phosphotransferase system cellobiose-specific component IIA
HWV68_03295	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HWV68_03300	COG2723	6-phospho-beta-galactosidase activity
HWV68_03305	COG2188	Transcriptional regulator
HWV68_03310	COG1940	carbohydrate kinase activity
HWV68_03315	COG1482	cell wall glycoprotein biosynthetic process
HWV68_03320	COG4124	Belongs to the glycosyl hydrolase 26 family
HWV68_03365	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HWV68_03370	COG0802	atpase or kinase
HWV68_03375	COG1214	PFAM Peptidase M22, glycoprotease
HWV68_03380	COG0456	acetyltransferase
HWV68_03385	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HWV68_03390	COG0488	(ABC) transporter
HWV68_03395	COG0315	cyclic pyranopterin monophosphate synthase activity
HWV68_03400	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
HWV68_03405	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HWV68_03410	COG0805	protein transport
HWV68_03420	COG1266	CAAX protease self-immunity
HWV68_03430	COG0459	protein refolding
HWV68_03440	COG3378	Phage plasmid primase P4 family
HWV68_03455	COG0270	DNA (cytosine-5-)-methyltransferase activity
HWV68_03460	COG0270	DNA (cytosine-5-)-methyltransferase activity
HWV68_03475	COG1401	restriction endodeoxyribonuclease activity
HWV68_03495	COG0457	Tetratricopeptide repeat
HWV68_03500	COG1063	alcohol dehydrogenase
HWV68_03505	COG2211	Major facilitator Superfamily
HWV68_03510	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWV68_03515	COG1842	Phage shock protein A
HWV68_03520	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HWV68_03525	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HWV68_03530	COG4260	virion core protein, lumpy skin disease virus
HWV68_03540	COG2814	Major facilitator Superfamily
HWV68_03545	COG1063	alcohol dehydrogenase
HWV68_03550	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HWV68_03555	COG0823	Involved in the tonB-independent uptake of proteins
HWV68_03570	COG2267	carboxylic ester hydrolase activity
HWV68_03580	COG2132	Multicopper oxidase
HWV68_03585	COG1113	amino acid transport
HWV68_03595	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
HWV68_03600	COG0714	Associated with various cellular activities
HWV68_03605	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
HWV68_03610	COG1305	Transglutaminase-like
HWV68_03615	COG0519	Catalyzes the synthesis of GMP from XMP
HWV68_03615	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HWV68_03620	COG2252	PERMEase
HWV68_03625	COG3064	Membrane
HWV68_03635	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
HWV68_03645	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HWV68_03650	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HWV68_03655	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HWV68_03660	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HWV68_03665	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HWV68_03670	COG0047	phosphoribosylformylglycinamidine synthase activity
HWV68_03675	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HWV68_03680	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HWV68_03685	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HWV68_03690	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HWV68_03695	COG0138	bifunctional purine biosynthesis protein purh
HWV68_03700	COG0151	Belongs to the GarS family
HWV68_03705	COG1522	sequence-specific DNA binding
HWV68_03710	COG0531	amino acid
HWV68_03720	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HWV68_03725	COG1470	cell adhesion involved in biofilm formation
HWV68_03730	COG4496	protein, YerC YecD
HWV68_03735	COG0069	glutamate synthase activity
HWV68_03740	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
HWV68_03745	COG0210	DNA helicase
HWV68_03750	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HWV68_03755	COG4851	CamS sex pheromone cAM373 precursor
HWV68_03760	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HWV68_03765	COG1285	pathogenesis
HWV68_03770	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWV68_03775	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HWV68_03780	COG0154	amidase activity
HWV68_03785	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HWV68_03790	COG1309	transcriptional regulator
HWV68_03795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HWV68_03800	COG1597	lipid kinase activity
HWV68_03805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HWV68_03810	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HWV68_03815	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HWV68_03820	COG1002	Type II restriction enzyme, methylase subunits
HWV68_03825	COG1061	Type III restriction enzyme res subunit
HWV68_03830	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HWV68_03850	COG5444	nuclease activity
HWV68_03855	COG3391	amine dehydrogenase activity
HWV68_03860	COG0457	Tetratricopeptide repeat
HWV68_03870	COG0217	transcriptional regulatory protein
HWV68_03880	COG1309	transcriptional regulator
HWV68_03885	COG3631	Ketosteroid isomerase-related protein
HWV68_03890	COG0702	epimerase
HWV68_03905	COG3546	catalase activity
HWV68_03910	COG0454	-acetyltransferase
HWV68_03920	COG5578	integral membrane protein
HWV68_03925	COG2972	Histidine kinase
HWV68_03930	COG2207	Transcriptional regulator
HWV68_03930	COG4753	response regulator
HWV68_03935	COG1653	transport
HWV68_03940	COG1175	transmembrane transport
HWV68_03945	COG0395	ABC-type sugar transport system, permease component
HWV68_03950	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HWV68_03955	COG2207	Transcriptional regulator
HWV68_03960	COG2755	lipolytic protein G-D-S-L family
HWV68_03970	COG5578	integral membrane protein
HWV68_03975	COG3401	FG-GAP repeat protein
HWV68_03980	COG3401	FG-GAP repeat protein
HWV68_03985	COG2755	lipolytic protein G-D-S-L family
HWV68_03990	COG1874	Beta-galactosidase
HWV68_04000	COG1653	transport
HWV68_04005	COG4209	transmembrane transport
HWV68_04010	COG0395	ABC-type sugar transport system, permease component
HWV68_04015	COG1486	melibiose metabolic process
HWV68_04020	COG2323	membrane
HWV68_04025	COG2329	Antibiotic biosynthesis monooxygenase
HWV68_04030	COG0346	lactoylglutathione lyase activity
HWV68_04045	COG5583	Uncharacterized small protein (DUF2292)
HWV68_04050	COG0670	Belongs to the BI1 family
HWV68_04055	COG0697	spore germination
HWV68_04060	COG1846	Transcriptional regulator
HWV68_04065	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWV68_04075	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HWV68_04075	COG2124	cytochrome p450
HWV68_04080	COG1368	sulfuric ester hydrolase activity
HWV68_04085	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HWV68_04090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HWV68_04095	COG1442	glycosyl transferase family 8
HWV68_04100	COG1216	Glycosyl transferase, family 2
HWV68_04105	COG1442	glycosyl transferase family 8
HWV68_04110	COG2223	nitrite transmembrane transporter activity
HWV68_04115	COG1011	Hydrolase
HWV68_04120	COG0531	amino acid
HWV68_04125	COG1012	belongs to the aldehyde dehydrogenase family
HWV68_04130	COG0840	transmembrane signaling receptor activity
HWV68_04135	COG0488	(ABC) transporter
HWV68_04145	COG0789	Transcriptional regulator
HWV68_04150	COG2814	Major facilitator Superfamily
HWV68_04160	COG0488	(ABC) transporter
HWV68_04165	COG0513	Belongs to the DEAD box helicase family
HWV68_04170	COG0456	acetyltransferase
HWV68_04175	COG2130	NADP-dependent
HWV68_04180	COG2211	Major facilitator Superfamily
HWV68_04185	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HWV68_04190	COG1120	ATPase activity
HWV68_04195	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWV68_04200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWV68_04205	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HWV68_04220	COG3866	Pectate lyase
HWV68_04225	COG0471	metal ion transport
HWV68_04230	COG3290	protein histidine kinase activity
HWV68_04235	COG4565	transcriptional regulatory protein
HWV68_04240	COG3181	Tripartite tricarboxylate transporter family receptor
HWV68_04245	COG2851	Citrate transporter
HWV68_04250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWV68_04255	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
HWV68_04260	COG1254	Belongs to the acylphosphatase family
HWV68_04265	COG2258	MOSC domain
HWV68_04285	COG0024	Methionine aminopeptidase
HWV68_04290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWV68_04290	COG1263	PTS System
HWV68_04295	COG1368	sulfuric ester hydrolase activity
HWV68_04310	COG1115	amino acid carrier protein
HWV68_04315	COG0531	amino acid
HWV68_04330	COG0697	spore germination
HWV68_04335	COG1263	PTS System
HWV68_04335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWV68_04340	COG0366	Alpha amylase catalytic
HWV68_04345	COG2188	Transcriptional regulator
HWV68_04350	COG0778	Nitroreductase
HWV68_04355	COG0737	Belongs to the 5'-nucleotidase family
HWV68_04360	COG0693	protein deglycase activity
HWV68_04365	COG2814	Major facilitator Superfamily
HWV68_04370	COG4840	Belongs to the UPF0435 family
HWV68_04375	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HWV68_04380	COG4980	gas vesicle protein
HWV68_04385	COG1295	ribonuclease BN
HWV68_04390	COG0477	Major facilitator Superfamily
HWV68_04395	COG0387	Pfam Sodium calcium exchanger
HWV68_04405	COG0668	transmembrane transport
HWV68_04410	COG0535	radical SAM domain protein
HWV68_04420	COG0726	polysaccharide deacetylase
HWV68_04425	COG2084	Dehydrogenase
HWV68_04430	COG0598	Magnesium transport protein CorA
HWV68_04435	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HWV68_04440	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HWV68_04450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HWV68_04455	COG4637	Psort location Cytoplasmic, score
HWV68_04465	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HWV68_04470	COG0022	dehydrogenase e1 component
HWV68_04475	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWV68_04480	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HWV68_04485	COG3284	Transcriptional regulator
HWV68_04495	COG1742	UPF0060 membrane protein
HWV68_04520	COG4842	Belongs to the WXG100 family
HWV68_04525	COG1486	melibiose metabolic process
HWV68_04530	COG1737	Transcriptional regulator
HWV68_04535	COG1263	PTS System
HWV68_04535	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWV68_04540	COG1132	(ABC) transporter
HWV68_04545	COG1132	(ABC) transporter
HWV68_04550	COG2259	Doxx family
HWV68_04555	COG2514	catechol 2,3-dioxygenase activity
HWV68_04560	COG1917	Cupin 2, conserved barrel domain protein
HWV68_04560	COG4977	sequence-specific DNA binding
HWV68_04565	COG2814	Major facilitator Superfamily
HWV68_04570	COG1082	Xylose isomerase domain protein TIM barrel
HWV68_04575	COG0673	inositol 2-dehydrogenase activity
HWV68_04580	COG4585	Histidine kinase
HWV68_04585	COG2197	response regulator
HWV68_04590	COG1131	(ABC) transporter
HWV68_04595	COG0842	Transport permease protein
HWV68_04595	COG1511	domain protein
HWV68_04600	COG0842	Transport permease protein
HWV68_04605	COG1695	Transcriptional regulator
HWV68_04610	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
HWV68_04615	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
HWV68_04620	COG1309	transcriptional regulator
HWV68_04625	COG2814	Major facilitator Superfamily
HWV68_04630	COG2318	DinB family
HWV68_04635	COG2814	Major facilitator Superfamily
HWV68_04640	COG1846	Transcriptional regulator
HWV68_04645	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
HWV68_04645	COG0392	lysyltransferase activity
HWV68_04650	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HWV68_04655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWV68_04660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWV68_04665	COG0384	phenazine biosynthesis protein PhzF
HWV68_04670	COG0778	Nitroreductase
HWV68_04685	COG1090	epimerase
HWV68_04690	COG2137	regulation of response to DNA damage stimulus
HWV68_04700	COG2814	Major facilitator Superfamily
HWV68_04715	COG3103	Sh3 type 3 domain protein
HWV68_04720	COG5658	integral membrane protein
HWV68_04725	COG0596	Alpha beta hydrolase
HWV68_04730	COG0463	Glycosyl transferase, family 2
HWV68_04735	COG4485	Bacterial membrane protein, YfhO
HWV68_04740	COG1988	membrane-bound metal-dependent
HWV68_04745	COG1194	a g-specific adenine glycosylase
HWV68_04755	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_04770	COG3557	Belongs to the UPF0374 family
HWV68_04775	COG1132	(ABC) transporter
HWV68_04780	COG4129	membrane
HWV68_04785	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HWV68_04790	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HWV68_04795	COG0735	belongs to the Fur family
HWV68_04905	COG4326	sporulation control protein
HWV68_04915	COG5577	PFAM Coat F domain
HWV68_04920	COG3340	Belongs to the peptidase S51 family
HWV68_04925	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HWV68_04930	COG0277	FAD linked oxidase domain protein
HWV68_04940	COG0753	catalase activity
HWV68_04945	COG1116	anion transmembrane transporter activity
HWV68_04950	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWV68_04955	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWV68_04960	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWV68_04970	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HWV68_04980	COG1476	TRANSCRIPTIONal
HWV68_04990	COG3382	B3 4 domain protein
HWV68_04995	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HWV68_05005	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HWV68_05010	COG0789	Transcriptional regulator
HWV68_05015	COG1664	Polymer-forming cytoskeletal
HWV68_05020	COG1664	Polymer-forming cytoskeletal
HWV68_05025	COG2766	serine protein kinase
HWV68_05030	COG2718	Belongs to the UPF0229 family
HWV68_05035	COG1846	Transcriptional regulator
HWV68_05040	COG1566	PFAM secretion protein HlyD family protein
HWV68_05045	COG2814	Major facilitator Superfamily
HWV68_05050	COG0655	NAD(P)H dehydrogenase (quinone) activity
HWV68_05070	COG1725	Transcriptional regulator
HWV68_05075	COG1131	(ABC) transporter
HWV68_05080	COG1131	(ABC) transporter
HWV68_05085	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HWV68_05090	COG1278	Cold shock
HWV68_05095	COG1464	Belongs to the NlpA lipoprotein family
HWV68_05100	COG3706	GGDEF domain
HWV68_05105	COG1823	symporter activity
HWV68_05125	COG5577	PFAM Coat F domain
HWV68_05130	COG4085	toxin activity
HWV68_05130	COG0737	Belongs to the 5'-nucleotidase family
HWV68_05130	COG1525	nuclease
HWV68_05135	COG3764	Sortase (surface protein transpeptidase)
HWV68_05140	COG0564	pseudouridine synthase activity
HWV68_05150	COG0517	IMP dehydrogenase activity
HWV68_05155	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HWV68_05160	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HWV68_05160	COG3153	acetyltransferase
HWV68_05165	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HWV68_05170	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HWV68_05175	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HWV68_05180	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HWV68_05185	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HWV68_05190	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HWV68_05195	COG2203	Gaf domain
HWV68_05195	COG4585	Histidine kinase
HWV68_05200	COG2197	response regulator
HWV68_05205	COG0431	NADPH-dependent FMN reductase
HWV68_05220	COG1388	LysM domain
HWV68_05220	COG0791	NLP P60 protein
HWV68_05225	COG1959	2 iron, 2 sulfur cluster binding
HWV68_05230	COG0668	transmembrane transport
HWV68_05235	COG2719	SpoVR family
HWV68_05240	COG1785	Belongs to the alkaline phosphatase family
HWV68_05245	COG1388	LysM domain
HWV68_05245	COG0791	NLP P60 protein
HWV68_05250	COG0583	DNA-binding transcription factor activity
HWV68_05255	COG0372	Belongs to the citrate synthase family
HWV68_05260	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_05265	COG0531	amino acid
HWV68_05270	COG0733	neurotransmitter:sodium symporter activity
HWV68_05275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWV68_05280	COG0456	acetyltransferase
HWV68_05295	COG1595	DNA-templated transcription, initiation
HWV68_05300	COG0667	Aldo Keto reductase
HWV68_05305	COG0204	Acyl-transferase
HWV68_05310	COG1253	flavin adenine dinucleotide binding
HWV68_05315	COG0789	Transcriptional regulator
HWV68_05320	COG0436	Aminotransferase
HWV68_05325	COG1253	flavin adenine dinucleotide binding
HWV68_05330	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HWV68_05335	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HWV68_05340	COG0584	glycerophosphoryl diester phosphodiesterase
HWV68_05350	COG0668	transmembrane transport
HWV68_05355	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HWV68_05360	COG0726	polysaccharide deacetylase
HWV68_05365	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HWV68_05370	COG1757	Na H antiporter
HWV68_05375	COG0589	response to stress
HWV68_05385	COG1132	(ABC) transporter
HWV68_05390	COG1132	(ABC) transporter
HWV68_05395	COG0702	epimerase
HWV68_05415	COG0189	ligase activity
HWV68_05420	COG0189	ligase activity
HWV68_05425	COG4399	Belongs to the UPF0754 family
HWV68_05430	COG3679	Belongs to the UPF0342 family
HWV68_05435	COG4335	DNA alkylation repair
HWV68_05440	COG0561	phosphatase activity
HWV68_05445	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HWV68_05450	COG0475	glutathione-regulated potassium exporter activity
HWV68_05455	COG0490	domain, Protein
HWV68_05465	COG1024	Enoyl-CoA hydratase
HWV68_05475	COG4152	abc transporter atp-binding protein
HWV68_05480	COG1668	transmembrane transport
HWV68_05485	COG0420	3'-5' exonuclease activity
HWV68_05490	COG4717	serine-type aminopeptidase activity
HWV68_05495	COG3481	metal-dependent phosphohydrolase, HD sub domain
HWV68_05505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HWV68_05535	COG1846	Transcriptional regulator
HWV68_05540	COG4980	gas vesicle protein
HWV68_05555	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HWV68_05560	COG0537	adenosine 5'-monophosphoramidase activity
HWV68_05565	COG1131	(ABC) transporter
HWV68_05570	COG4473	ABC transporter
HWV68_05580	COG1473	amidohydrolase
HWV68_05585	COG3069	C4-dicarboxylate transmembrane transporter activity
HWV68_05595	COG2329	Antibiotic biosynthesis monooxygenase
HWV68_05600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HWV68_05605	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HWV68_05620	COG1309	transcriptional regulator
HWV68_05625	COG1511	domain protein
HWV68_05630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HWV68_05635	COG4377	Putative membrane peptidase family (DUF2324)
HWV68_05645	COG1363	Peptidase, m42
HWV68_05650	COG4405	Protein conserved in bacteria
HWV68_05655	COG1301	dicarboxylic acid transport
HWV68_05665	COG1234	tRNA 3'-trailer cleavage
HWV68_05670	COG0095	Lipoate-protein ligase
HWV68_05675	COG0702	epimerase
HWV68_05680	COG0318	PFAM AMP-dependent synthetase and ligase
HWV68_05690	COG0501	Belongs to the peptidase M48B family
HWV68_05695	COG1404	Belongs to the peptidase S8 family
HWV68_05700	COG0456	acetyltransferase
HWV68_05705	COG0604	alcohol dehydrogenase
HWV68_05710	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
HWV68_05715	COG0406	alpha-ribazole phosphatase activity
HWV68_05720	COG0183	Belongs to the thiolase family
HWV68_05725	COG0318	PFAM AMP-dependent synthetase and ligase
HWV68_05730	COG1268	BioY protein
HWV68_05735	COG0840	transmembrane signaling receptor activity
HWV68_05740	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWV68_05740	COG0723	plastoquinol--plastocyanin reductase activity
HWV68_05745	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_05755	COG4903	ComK protein
HWV68_05760	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_05770	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWV68_05785	COG0398	Pfam SNARE associated Golgi protein
HWV68_05790	COG0681	Belongs to the peptidase S26 family
HWV68_05795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HWV68_05800	COG1846	Transcriptional regulator
HWV68_05805	COG0738	Major facilitator superfamily
HWV68_05810	COG0673	inositol 2-dehydrogenase activity
HWV68_05815	COG0561	phosphatase activity
HWV68_05820	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HWV68_05825	COG1609	Transcriptional regulator
HWV68_05830	COG3180	Ammonia monooxygenase
HWV68_05835	COG0477	Major facilitator Superfamily
HWV68_05835	COG2814	Major facilitator Superfamily
HWV68_05840	COG4533	DNA binding
HWV68_05850	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
HWV68_05855	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
HWV68_05860	COG1074	ATP-dependent DNA helicase activity
HWV68_05865	COG0420	3'-5' exonuclease activity
HWV68_05870	COG0419	ATPase involved in DNA repair
HWV68_05875	COG1403	HNH endonuclease
HWV68_05915	COG5337	Spore coat protein CotH
HWV68_05920	COG0179	Fumarylacetoacetate (FAA) hydrolase
HWV68_05930	COG1404	Belongs to the peptidase S8 family
HWV68_05940	COG0367	asparagine synthase
HWV68_05945	COG2318	DinB family
HWV68_05950	COG1562	ergosterol biosynthetic process
HWV68_05955	COG0534	Mate efflux family protein
HWV68_05960	COG1917	Cupin 2, conserved barrel domain protein
HWV68_05960	COG2207	Transcriptional regulator
HWV68_05965	COG1609	Transcriptional regulator
HWV68_05970	COG0673	inositol 2-dehydrogenase activity
HWV68_05975	COG2318	DinB family
HWV68_05980	COG1279	arginine transmembrane transporter activity
HWV68_05985	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HWV68_05990	COG1357	PFAM Pentapeptide repeats (8 copies)
HWV68_05995	COG2267	carboxylic ester hydrolase activity
HWV68_06000	COG0529	Catalyzes the synthesis of activated sulfate
HWV68_06005	COG2046	Belongs to the sulfate adenylyltransferase family
HWV68_06010	COG0175	sulfate reduction
HWV68_06015	COG2045	Belongs to the ComB family
HWV68_06020	COG1809	phosphosulfolactate synthase activity
HWV68_06025	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HWV68_06030	COG4948	Mandelate Racemase Muconate Lactonizing
HWV68_06035	COG2814	Major facilitator Superfamily
HWV68_06040	COG0454	-acetyltransferase
HWV68_06045	COG2153	protein acetylation
HWV68_06050	COG0646	methionine synthase
HWV68_06050	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HWV68_06055	COG1666	GTP binding
HWV68_06060	COG2996	Protein conserved in bacteria
HWV68_06080	COG1695	Transcriptional regulator
HWV68_06095	COG3227	Zinc metalloprotease (Elastase)
HWV68_06100	COG1307	EDD domain protein, DegV family
HWV68_06105	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HWV68_06125	COG0561	phosphatase activity
HWV68_06130	COG1073	alpha beta
HWV68_06135	COG2151	metal-sulfur cluster biosynthetic enzyme
HWV68_06145	COG0277	FAD linked oxidase domain protein
HWV68_06150	COG2271	Major facilitator Superfamily
HWV68_06155	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HWV68_06160	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HWV68_06170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HWV68_06175	COG0505	Belongs to the CarA family
HWV68_06180	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HWV68_06185	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HWV68_06200	COG2267	carboxylic ester hydrolase activity
HWV68_06210	COG1744	ABC transporter substrate-binding protein PnrA-like
HWV68_06225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HWV68_06230	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HWV68_06235	COG5504	Zn-dependent protease
HWV68_06240	COG0444	Belongs to the ABC transporter superfamily
HWV68_06245	COG4608	Belongs to the ABC transporter superfamily
HWV68_06255	COG0601	transmembrane transport
HWV68_06260	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HWV68_06270	COG0180	Tryptophanyl-tRNA synthetase
HWV68_06275	COG4166	transmembrane transport
HWV68_06280	COG0601	transmembrane transport
HWV68_06285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HWV68_06290	COG0444	Belongs to the ABC transporter superfamily
HWV68_06295	COG4608	Belongs to the ABC transporter superfamily
HWV68_06300	COG2814	Major facilitator Superfamily
HWV68_06305	COG0456	acetyltransferase
HWV68_06310	COG1393	Belongs to the ArsC family
HWV68_06315	COG0861	Integral membrane protein TerC family
HWV68_06325	COG4862	establishment of competence for transformation
HWV68_06335	COG4469	Competence protein
HWV68_06340	COG1164	Oligoendopeptidase f
HWV68_06355	COG2346	COG2346, Truncated hemoglobins
HWV68_06360	COG0741	lytic transglycosylase activity
HWV68_06365	COG4116	CYTH
HWV68_06375	COG2357	RelA SpoT domain protein
HWV68_06380	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HWV68_06385	COG0564	pseudouridine synthase activity
HWV68_06390	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HWV68_06395	COG0569	domain protein
HWV68_06395	COG0475	glutathione-regulated potassium exporter activity
HWV68_06400	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HWV68_06405	COG0352	thiamine-phosphate diphosphorylase activity
HWV68_06410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWV68_06415	COG2104	thiamine diphosphate biosynthetic process
HWV68_06420	COG2022	thiamine diphosphate biosynthetic process
HWV68_06425	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HWV68_06430	COG0351	phosphomethylpyrimidine kinase
HWV68_06435	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HWV68_06490	COG0210	DNA helicase
HWV68_06500	COG2153	protein acetylation
HWV68_06505	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HWV68_06510	COG2382	esterase
HWV68_06515	COG0626	cystathionine gamma-synthase activity
HWV68_06520	COG0626	cystathionine gamma-synthase activity
HWV68_06525	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWV68_06530	COG5505	Protein of unknown function (DUF819)
HWV68_06565	COG3677	Transposase
HWV68_06580	COG5484	DNA packaging
HWV68_06585	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HWV68_06590	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_06600	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWV68_06600	COG3711	transcriptional antiterminator
HWV68_06605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HWV68_06605	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HWV68_06605	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWV68_06610	COG1482	cell wall glycoprotein biosynthetic process
HWV68_06620	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWV68_06630	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HWV68_06645	COG0109	protoheme IX farnesyltransferase activity
HWV68_06655	COG0726	polysaccharide deacetylase
HWV68_06670	COG5504	Zn-dependent protease
HWV68_06675	COG2205	protein histidine kinase activity
HWV68_06685	COG3383	formate dehydrogenase (NAD+) activity
HWV68_06690	COG2427	Protein of unknown function (DUF1641)
HWV68_06700	COG1051	belongs to the nudix hydrolase family
HWV68_06710	COG2124	cytochrome p450
HWV68_06715	COG1819	glycosyl
HWV68_06725	COG1587	Uroporphyrinogen-III synthase
HWV68_06730	COG0390	transport system, permease component
HWV68_06735	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HWV68_06740	COG0697	spore germination
HWV68_06745	COG4297	protein containing double-stranded beta helix domain
HWV68_06755	COG1252	NADH dehydrogenase
HWV68_06760	COG1904	glucuronate isomerase
HWV68_06765	COG2211	Major facilitator Superfamily
HWV68_06770	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HWV68_06775	COG1063	alcohol dehydrogenase
HWV68_06780	COG1312	Catalyzes the dehydration of D-mannonate
HWV68_06785	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_06790	COG2271	Major facilitator Superfamily
HWV68_06795	COG1609	Transcriptional regulator
HWV68_06800	COG0246	Mannitol dehydrogenase
HWV68_06805	COG2721	sulfolactate sulfo-lyase activity
HWV68_06810	COG0730	response to heat
HWV68_06815	COG2318	DinB family
HWV68_06820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HWV68_06825	COG0457	Tetratricopeptide repeat
HWV68_06835	COG2350	Protein conserved in bacteria
HWV68_06840	COG1388	LysM domain
HWV68_06840	COG5632	N-Acetylmuramoyl-L-alanine amidase
HWV68_06840	COG3409	Peptidoglycan-binding domain 1 protein
HWV68_06850	COG4195	phage-related replication protein
HWV68_06855	COG3546	catalase activity
HWV68_06860	COG2856	Zn peptidase
HWV68_06865	COG1396	sequence-specific DNA binding
HWV68_06875	COG1522	sequence-specific DNA binding
HWV68_06880	COG1484	DNA-dependent DNA replication
HWV68_06900	COG1595	DNA-templated transcription, initiation
HWV68_06905	COG5484	DNA packaging
HWV68_06905	COG3728	DNA packaging
HWV68_06910	COG1783	phage Terminase large subunit
HWV68_06915	COG5518	Phage portal protein
HWV68_06920	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HWV68_06925	COG4653	Phage capsid family
HWV68_06975	COG5412	phage tail tape measure protein
HWV68_06975	COG3953	SLT domain
HWV68_06980	COG1652	LysM domain
HWV68_06985	COG4193	domain, Protein
HWV68_06995	COG3628	GPW Gp25 family protein
HWV68_07000	COG3299	homolog of phage Mu protein gp47
HWV68_07005	COG3778	Protein conserved in bacteria
HWV68_07045	COG5632	N-Acetylmuramoyl-L-alanine amidase
HWV68_07045	COG3409	Peptidoglycan-binding domain 1 protein
HWV68_07065	COG0306	phosphate transporter
HWV68_07070	COG1392	Phosphate transport regulator
HWV68_07075	COG0531	amino acid
HWV68_07080	COG0346	lactoylglutathione lyase activity
HWV68_07090	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HWV68_07095	COG0463	Glycosyl transferase, family 2
HWV68_07105	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWV68_07110	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HWV68_07115	COG2362	D-Aminopeptidase
HWV68_07120	COG0601	transmembrane transport
HWV68_07125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HWV68_07130	COG0444	Belongs to the ABC transporter superfamily
HWV68_07135	COG4166	transmembrane transport
HWV68_07140	COG1619	proteins homologs of microcin C7 resistance protein MccF
HWV68_07145	COG4948	Mandelate Racemase Muconate Lactonizing
HWV68_07150	COG0791	NLP P60 protein
HWV68_07155	COG4608	Belongs to the ABC transporter superfamily
HWV68_07160	COG2706	6-phosphogluconolactonase activity
HWV68_07165	COG1834	amidinotransferase
HWV68_07170	COG1607	acyl-coa hydrolase
HWV68_07175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HWV68_07175	COG1017	nitric oxide dioxygenase activity
HWV68_07185	COG2323	membrane
HWV68_07190	COG2318	DinB family
HWV68_07195	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWV68_07200	COG2076	Multidrug Resistance protein
HWV68_07205	COG2076	Multidrug Resistance protein
HWV68_07210	COG0788	formyltetrahydrofolate deformylase activity
HWV68_07215	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HWV68_07220	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HWV68_07225	COG1764	response to oxidative stress
HWV68_07230	COG1846	Transcriptional regulator
HWV68_07235	COG1764	response to oxidative stress
HWV68_07245	COG0590	tRNA wobble adenosine to inosine editing
HWV68_07250	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HWV68_07255	COG1404	Belongs to the peptidase S8 family
HWV68_07260	COG1366	Belongs to the anti-sigma-factor antagonist family
HWV68_07265	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
HWV68_07270	COG1122	ATPase activity
HWV68_07275	COG4721	ABC-type cobalt transport system, permease component
HWV68_07285	COG0745	RESPONSE REGULATOR receiver
HWV68_07290	COG3850	Histidine kinase
HWV68_07290	COG5002	protein histidine kinase activity
HWV68_07295	COG3212	peptidase
HWV68_07300	COG3212	peptidase
HWV68_07310	COG2239	Acts as a magnesium transporter
HWV68_07315	COG0789	Transcriptional regulator
HWV68_07330	COG1846	Transcriptional regulator
HWV68_07335	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HWV68_07340	COG0726	polysaccharide deacetylase
HWV68_07345	COG1408	metallophosphoesterase
HWV68_07355	COG0463	Glycosyl transferase, family 2
HWV68_07360	COG1793	dna ligase
HWV68_07360	COG3285	dna ligase
HWV68_07365	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
HWV68_07370	COG3300	MHYT domain
HWV68_07370	COG5001	Diguanylate cyclase
HWV68_07375	COG0586	Pfam SNARE associated Golgi protein
HWV68_07380	COG0861	Integral membrane protein TerC family
HWV68_07385	COG1191	sigma factor activity
HWV68_07405	COG0501	Belongs to the peptidase M48B family
HWV68_07410	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HWV68_07425	COG3594	Acyltransferase
HWV68_07430	COG5002	protein histidine kinase activity
HWV68_07435	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HWV68_07445	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
HWV68_07450	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
HWV68_07455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HWV68_07460	COG0436	Aminotransferase
HWV68_07465	COG1850	ribulose-bisphosphate carboxylase activity
HWV68_07470	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
HWV68_07475	COG0235	Class ii aldolase
HWV68_07480	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
HWV68_07485	COG3339	Conserved Protein
HWV68_07500	COG3852	Histidine kinase
HWV68_07505	COG1846	Transcriptional regulator
HWV68_07510	COG1360	Flagellar Motor Protein
HWV68_07515	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HWV68_07520	COG0542	response to heat
HWV68_07525	COG3949	Membrane
HWV68_07530	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HWV68_07535	COG0720	synthase
HWV68_07540	COG0602	queuosine metabolic process
HWV68_07545	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HWV68_07550	COG1733	regulation of RNA biosynthetic process
HWV68_07555	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_07560	COG1388	LysM domain
HWV68_07560	COG4641	Protein conserved in bacteria
HWV68_07565	COG1388	LysM domain
HWV68_07580	COG4873	Protein conserved in bacteria
HWV68_07590	COG3773	Cell wall hydrolase
HWV68_07595	COG2244	polysaccharide biosynthetic process
HWV68_07600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWV68_07605	COG2217	Heavy metal translocating P-type atpase
HWV68_07615	COG0006	proline dipeptidase activity
HWV68_07620	COG1609	Transcriptional regulator
HWV68_07625	COG3711	transcriptional antiterminator
HWV68_07630	COG2190	(PTS) system
HWV68_07630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWV68_07630	COG1263	PTS System
HWV68_07635	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWV68_07640	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HWV68_07650	COG1533	DNA photolyase activity
HWV68_07655	COG0456	acetyltransferase
HWV68_07660	COG0840	transmembrane signaling receptor activity
HWV68_07665	COG2084	Dehydrogenase
HWV68_07670	COG2340	Cysteine-rich secretory protein family
HWV68_07675	COG0768	penicillin binding
HWV68_07680	COG4191	Histidine kinase
HWV68_07685	COG0436	Aminotransferase
HWV68_07695	COG0835	chemotaxis
HWV68_07695	COG0784	Response regulator, receiver
HWV68_07705	COG2814	Major facilitator Superfamily
HWV68_07710	COG1376	ErfK ybiS ycfS ynhG family protein
HWV68_07715	COG1408	metallophosphoesterase
HWV68_07720	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_07725	COG3409	Peptidoglycan-binding domain 1 protein
HWV68_07730	COG3409	Peptidoglycan-binding domain 1 protein
HWV68_07740	COG2200	EAL domain
HWV68_07745	COG4703	Protein of unknown function (DUF1797)
HWV68_07750	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
HWV68_07760	COG0517	IMP dehydrogenase activity
HWV68_07765	COG0583	DNA-binding transcription factor activity
HWV68_07770	COG0716	FMN binding
HWV68_07780	COG0716	FMN binding
HWV68_07785	COG2171	N-acyltransferase activity
HWV68_07790	COG1473	amidohydrolase
HWV68_07800	COG0668	transmembrane transport
HWV68_07805	COG0450	alkyl hydroperoxide reductase
HWV68_07810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWV68_07825	COG0746	molybdenum cofactor guanylyltransferase activity
HWV68_07830	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HWV68_07835	COG0303	'Molybdopterin
HWV68_07840	COG1763	Mo-molybdopterin cofactor biosynthetic process
HWV68_07845	COG0314	molybdopterin synthase activity
HWV68_07850	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HWV68_07855	COG1132	(ABC) transporter
HWV68_07860	COG1132	(ABC) transporter
HWV68_07870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWV68_07875	COG1136	(ABC) transporter
HWV68_07880	COG0577	efflux transmembrane transporter activity
HWV68_07885	COG1349	DNA-binding transcription factor activity
HWV68_07890	COG1105	Belongs to the carbohydrate kinase PfkB family
HWV68_07895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWV68_07895	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HWV68_07895	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HWV68_07900	COG0681	Belongs to the peptidase S26 family
HWV68_07910	COG0488	(ABC) transporter
HWV68_07915	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HWV68_07920	COG2309	aminopeptidase activity
HWV68_07930	COG1077	Cell shape determining protein MreB Mrl
HWV68_07935	COG2002	toxin-antitoxin pair type II binding
HWV68_07940	COG3852	Histidine kinase
HWV68_07945	COG2105	PFAM AIG2 family protein
HWV68_07945	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HWV68_07950	COG0569	domain protein
HWV68_07955	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
HWV68_07960	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HWV68_07970	COG0561	phosphatase activity
HWV68_07975	COG0242	peptide deformylase activity
HWV68_07985	COG0497	DNA recombination
HWV68_07990	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HWV68_07995	COG0022	dehydrogenase e1 component
HWV68_08000	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWV68_08005	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HWV68_08010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWV68_08020	COG1982	Orn Lys Arg decarboxylase major
HWV68_08025	COG4476	Belongs to the UPF0223 family
HWV68_08030	COG4493	Belongs to the UPF0637 family
HWV68_08040	COG0483	inositol monophosphate 1-phosphatase activity
HWV68_08050	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
HWV68_08070	COG1595	DNA-templated transcription, initiation
HWV68_08100	COG4896	Protein conserved in bacteria
HWV68_08110	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
HWV68_08115	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HWV68_08120	COG2066	Belongs to the glutaminase family
HWV68_08125	COG4838	Belongs to the UPF0358 family
HWV68_08130	COG0772	Belongs to the SEDS family
HWV68_08135	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
HWV68_08140	COG1612	heme a metabolic process
HWV68_08145	COG0109	protoheme IX farnesyltransferase activity
HWV68_08150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HWV68_08150	COG2010	Cytochrome c
HWV68_08155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HWV68_08160	COG1845	cytochrome c oxidase, subunit III
HWV68_08165	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HWV68_08170	COG3336	cytochrome c oxidase
HWV68_08180	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
HWV68_08185	COG2340	Cysteine-rich secretory protein family
HWV68_08200	COG3679	Belongs to the UPF0342 family
HWV68_08205	COG4471	UPF0298 protein
HWV68_08210	COG0742	ribosomal rna small subunit methyltransferase
HWV68_08215	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HWV68_08220	COG3314	Sporulation integral membrane protein YlbJ
HWV68_08225	COG1752	Esterase of the alpha-beta hydrolase superfamily
HWV68_08230	COG3480	Lon protease (S16) C-terminal proteolytic domain
HWV68_08235	COG1323	Belongs to the UPF0348 family
HWV68_08245	COG1399	metal-binding, possibly nucleic acid-binding protein
HWV68_08260	COG0454	-acetyltransferase
HWV68_08265	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HWV68_08270	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
HWV68_08275	COG2001	Belongs to the MraZ family
HWV68_08280	COG0275	rRNA processing
HWV68_08285	COG4839	cell division protein FtsL
HWV68_08295	COG0768	penicillin binding
HWV68_08300	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HWV68_08305	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HWV68_08310	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HWV68_08315	COG0772	Belongs to the SEDS family
HWV68_08320	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HWV68_08325	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HWV68_08330	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HWV68_08335	COG3879	Bacterial protein of unknown function (DUF881)
HWV68_08340	COG3879	Bacterial protein of unknown function (DUF881)
HWV68_08345	COG3856	small basic protein
HWV68_08350	COG0849	cell division
HWV68_08355	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HWV68_08360	COG1404	Belongs to the peptidase S8 family
HWV68_08360	COG4412	M6 family metalloprotease domain protein
HWV68_08370	COG1191	sigma factor activity
HWV68_08375	COG1191	sigma factor activity
HWV68_08380	COG1119	ATPase activity
HWV68_08385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HWV68_08390	COG1873	PFAM PRC-barrel domain
HWV68_08400	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HWV68_08405	COG1799	cell septum assembly
HWV68_08410	COG0762	integral membrane protein
HWV68_08415	COG2302	S4 RNA-binding domain
HWV68_08420	COG3599	regulation of cell shape
HWV68_08425	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HWV68_08430	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HWV68_08435	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HWV68_08440	COG0564	pseudouridine synthase activity
HWV68_08445	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
HWV68_08450	COG2233	PERMEase
HWV68_08455	COG0540	Belongs to the ATCase OTCase family
HWV68_08460	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HWV68_08465	COG0505	Belongs to the CarA family
HWV68_08470	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HWV68_08475	COG0543	2 iron, 2 sulfur cluster binding
HWV68_08480	COG0167	dihydroorotate dehydrogenase activity
HWV68_08485	COG0284	orotidine-5'-phosphate decarboxylase activity
HWV68_08490	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
HWV68_08495	COG0175	sulfate reduction
HWV68_08500	COG0306	phosphate transporter
HWV68_08505	COG2046	Belongs to the sulfate adenylyltransferase family
HWV68_08510	COG0529	Catalyzes the synthesis of activated sulfate
HWV68_08515	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HWV68_08520	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
HWV68_08525	COG1648	precorrin-2 dehydrogenase activity
HWV68_08530	COG1293	RNA-binding protein homologous to eukaryotic snRNP
HWV68_08535	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HWV68_08540	COG1561	YicC-like family, N-terminal region
HWV68_08550	COG0194	GDP metabolic process
HWV68_08555	COG1758	RNA polymerase activity
HWV68_08560	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HWV68_08565	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HWV68_08570	COG0242	peptide deformylase activity
HWV68_08575	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HWV68_08580	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HWV68_08580	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HWV68_08585	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HWV68_08590	COG0631	protein serine/threonine phosphatase activity
HWV68_08595	COG0515	serine threonine protein kinase
HWV68_08595	COG2815	serine threonine protein kinase
HWV68_08600	COG1162	GTPase activity
HWV68_08605	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HWV68_08610	COG1564	THIamine pyrophosphokinase
HWV68_08620	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HWV68_08625	COG1302	Protein conserved in bacteria
HWV68_08630	COG1461	Dihydroxyacetone kinase
HWV68_08635	COG1760	l-serine dehydratase
HWV68_08640	COG1760	l-serine dehydratase
HWV68_08645	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HWV68_08650	COG1349	DNA-binding transcription factor activity
HWV68_08650	COG2050	protein possibly involved in aromatic compounds catabolism
HWV68_08655	COG0416	fatty acid biosynthetic process
HWV68_08660	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HWV68_08665	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_08675	COG0571	ribonuclease III activity
HWV68_08680	COG1196	nuclear chromosome segregation
HWV68_08685	COG0552	protein localization to endoplasmic reticulum
HWV68_08695	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
HWV68_08700	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HWV68_08705	COG0228	four-way junction DNA binding
HWV68_08710	COG1837	Belongs to the UPF0109 family
HWV68_08720	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HWV68_08725	COG0336	Belongs to the RNA methyltransferase TrmD family
HWV68_08730	COG0335	large ribosomal subunit rRNA binding
HWV68_08735	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HWV68_08740	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HWV68_08750	COG2257	FlhB HrpN YscU SpaS Family
HWV68_08755	COG0045	succinate-CoA ligase (ADP-forming) activity
HWV68_08760	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HWV68_08765	COG0758	DNA mediated transformation
HWV68_08770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HWV68_08775	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HWV68_08780	COG4974	Belongs to the 'phage' integrase family
HWV68_08785	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HWV68_08790	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HWV68_08795	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HWV68_08800	COG1815	bacterial-type flagellum-dependent cell motility
HWV68_08805	COG1558	bacterial-type flagellum-dependent cell motility
HWV68_08810	COG1677	Flagellar hook-basal body complex protein FliE
HWV68_08815	COG1766	The M ring may be actively involved in energy transduction
HWV68_08820	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HWV68_08825	COG1317	bacterial-type flagellum organization
HWV68_08830	COG1157	protein secretion by the type III secretion system
HWV68_08835	COG2882	bacterial-type flagellum organization
HWV68_08840	COG3334	PFAM MgtE intracellular
HWV68_08845	COG3144	bacterial-type flagellum assembly
HWV68_08850	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HWV68_08855	COG4786	Flagellar basal body rod
HWV68_08860	COG1582	Flagellar protein (FlbD)
HWV68_08865	COG1580	Controls the rotational direction of flagella during chemotaxis
HWV68_08870	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HWV68_08875	COG1776	CheC inhibitor of MCP methylation
HWV68_08875	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HWV68_08880	COG2201	protein-glutamate methylesterase activity
HWV68_08885	COG3190	flagellar
HWV68_08890	COG1338	Plays a role in the flagellum-specific transport system
HWV68_08895	COG1987	bacterial-type flagellum assembly
HWV68_08900	COG1684	flagellar biosynthetic protein fliR
HWV68_08905	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HWV68_08910	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HWV68_08915	COG1419	protein localization to endoplasmic reticulum
HWV68_08920	COG0455	bacterial-type flagellum organization
HWV68_08925	COG2201	protein-glutamate methylesterase activity
HWV68_08930	COG0643	Histidine kinase
HWV68_08930	COG2198	Histidine kinase
HWV68_08935	COG0835	chemotaxis
HWV68_08940	COG1776	CheC inhibitor of MCP methylation
HWV68_08945	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
HWV68_08950	COG1191	sigma factor activity
HWV68_08960	COG0052	Belongs to the universal ribosomal protein uS2 family
HWV68_08965	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HWV68_08970	COG0528	UMP kinase activity
HWV68_08975	COG0233	cytoplasmic translational termination
HWV68_08980	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HWV68_08985	COG4589	Belongs to the CDS family
HWV68_08990	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HWV68_08995	COG0750	zinc metalloprotease
HWV68_09000	COG0442	prolyl-tRNA aminoacylation
HWV68_09005	COG2176	DNA-directed DNA polymerase activity
HWV68_09010	COG0779	Required for maturation of 30S ribosomal subunits
HWV68_09015	COG0195	Participates in both transcription termination and antitermination
HWV68_09020	COG2740	Nucleic-acid-binding protein implicated in transcription termination
HWV68_09025	COG1358	cellular component organization or biogenesis
HWV68_09030	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HWV68_09035	COG1550	Protein conserved in bacteria
HWV68_09040	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HWV68_09045	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HWV68_09050	COG0196	riboflavin kinase activity
HWV68_09055	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HWV68_09060	COG1185	polyribonucleotide nucleotidyltransferase activity
HWV68_09065	COG0726	polysaccharide deacetylase
HWV68_09070	COG0612	Peptidase, M16
HWV68_09075	COG1873	PFAM PRC-barrel domain
HWV68_09080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HWV68_09085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HWV68_09090	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HWV68_09095	COG0527	aspartate kinase activity
HWV68_09100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HWV68_09105	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
HWV68_09110	COG0740	serine-type endopeptidase activity
HWV68_09120	COG4980	gas vesicle protein
HWV68_09120	COG1674	ftsk spoiiie
HWV68_09125	COG2188	Transcriptional regulator
HWV68_09130	COG2814	Major facilitator Superfamily
HWV68_09135	COG0612	Peptidase, M16
HWV68_09140	COG0612	Peptidase, M16
HWV68_09145	COG0300	oxidoreductase activity
HWV68_09160	COG1426	Protein conserved in bacteria
HWV68_09165	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HWV68_09170	COG1058	Belongs to the CinA family
HWV68_09170	COG1546	Belongs to the CinA family
HWV68_09175	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HWV68_09180	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HWV68_09185	COG1418	mRNA catabolic process
HWV68_09190	COG1692	metallophosphoesterase
HWV68_09195	COG2359	stage V sporulation protein S
HWV68_09200	COG1063	alcohol dehydrogenase
HWV68_09205	COG0156	8-amino-7-oxononanoate synthase activity
HWV68_09210	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HWV68_09215	COG4550	Control of competence regulator ComK, YlbF/YmcA
HWV68_09225	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HWV68_09230	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HWV68_09245	COG3226	Transcriptional regulator
HWV68_09250	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWV68_09260	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HWV68_09265	COG3321	synthase
HWV68_09270	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HWV68_09270	COG2070	2-Nitropropane dioxygenase
HWV68_09275	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWV68_09280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HWV68_09285	COG3425	synthase
HWV68_09290	COG1024	Enoyl-CoA hydratase
HWV68_09295	COG1024	Enoyl-CoA hydratase
HWV68_09300	COG3321	synthase
HWV68_09300	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_09300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_09300	COG0318	PFAM AMP-dependent synthetase and ligase
HWV68_09300	COG0300	oxidoreductase activity
HWV68_09305	COG4221	oxidoreductase activity
HWV68_09305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWV68_09305	COG3321	synthase
HWV68_09305	COG0300	oxidoreductase activity
HWV68_09310	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_09310	COG3321	synthase
HWV68_09310	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWV68_09310	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_09310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HWV68_09315	COG4221	oxidoreductase activity
HWV68_09315	COG3321	synthase
HWV68_09315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_09315	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_09320	COG3321	synthase
HWV68_09320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWV68_09320	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HWV68_09320	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HWV68_09325	COG2124	cytochrome p450
HWV68_09335	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWV68_09340	COG1404	Belongs to the peptidase S8 family
HWV68_09345	COG4195	phage-related replication protein
HWV68_09350	COG1764	response to oxidative stress
HWV68_09355	COG2076	Multidrug Resistance protein
HWV68_09360	COG2076	Multidrug Resistance protein
HWV68_09375	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HWV68_09380	COG1923	regulation of RNA biosynthetic process
HWV68_09395	COG1780	Probably involved in ribonucleotide reductase function
HWV68_09400	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HWV68_09405	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HWV68_09410	COG4112	unkown
HWV68_09415	COG0860	N-Acetylmuramoyl-L-alanine amidase
HWV68_09420	COG0464	growth
HWV68_09425	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HWV68_09430	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
HWV68_09435	COG0789	Transcriptional regulator
HWV68_09440	COG0174	glutamine synthetase
HWV68_09460	COG4282	regulation of fungal-type cell wall biogenesis
HWV68_09470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWV68_09500	COG0135	phosphoribosylanthranilate isomerase activity
HWV68_09505	COG2211	Major facilitator Superfamily
HWV68_09510	COG3507	Belongs to the glycosyl hydrolase 43 family
HWV68_09515	COG1940	carbohydrate kinase activity
HWV68_09520	COG2115	Belongs to the xylose isomerase family
HWV68_09525	COG1070	Carbohydrate kinase
HWV68_09535	COG1525	nuclease
HWV68_09540	COG2814	Major facilitator Superfamily
HWV68_09545	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HWV68_09555	COG0756	dUTP diphosphatase activity
HWV68_09570	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HWV68_09595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HWV68_09610	COG3832	glyoxalase III activity
HWV68_09620	COG0697	spore germination
HWV68_09625	COG0531	amino acid
HWV68_09655	COG4195	phage-related replication protein
HWV68_09665	COG0346	lactoylglutathione lyase activity
HWV68_09670	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HWV68_09675	COG1388	LysM domain
HWV68_09680	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HWV68_09685	COG4224	UPF0291 protein
HWV68_09690	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HWV68_09700	COG3763	UPF0154 protein
HWV68_09710	COG0785	Cytochrome C biogenesis protein
HWV68_09715	COG2201	protein-glutamate methylesterase activity
HWV68_09720	COG4846	Membrane protein involved in cytochrome C biogenesis
HWV68_09730	COG0071	Belongs to the small heat shock protein (HSP20) family
HWV68_09745	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HWV68_09750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWV68_09770	COG0824	Thioesterase
HWV68_09780	COG4841	protein insertion into membrane
HWV68_09785	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HWV68_09790	COG1832	CoA-binding protein
HWV68_09795	COG0187	DNA topoisomerase II activity
HWV68_09800	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HWV68_09810	COG1115	amino acid carrier protein
HWV68_09815	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
HWV68_09825	COG5520	Belongs to the glycosyl hydrolase 30 family
HWV68_09830	COG3507	Belongs to the glycosyl hydrolase 43 family
HWV68_09835	COG2246	polysaccharide biosynthetic process
HWV68_09840	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HWV68_09845	COG0586	Pfam SNARE associated Golgi protein
HWV68_09850	COG2404	hydrolase activity, acting on ester bonds
HWV68_09855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HWV68_09860	COG1024	Enoyl-CoA hydratase
HWV68_09865	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HWV68_09870	COG0511	ligase activity, forming carbon-carbon bonds
HWV68_09875	COG0439	Biotin carboxylase
HWV68_09880	COG0318	PFAM AMP-dependent synthetase and ligase
HWV68_09885	COG1960	acyl-CoA dehydrogenase activity
HWV68_09900	COG1649	PFAM Uncharacterised BCR, COG1649
HWV68_09910	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_09910	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HWV68_09915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_09920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_09925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_09930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_09935	COG2027	D-alanyl-D-alanine carboxypeptidase
HWV68_09940	COG2017	converts alpha-aldose to the beta-anomer
HWV68_09945	COG0534	Mate efflux family protein
HWV68_09960	COG0582	viral genome integration into host DNA
HWV68_09965	COG0166	Belongs to the GPI family
HWV68_09970	COG0405	Gamma-glutamyltransferase
HWV68_09975	COG0583	DNA-binding transcription factor activity
HWV68_09980	COG0604	alcohol dehydrogenase
HWV68_09985	COG0493	'glutamate synthase
HWV68_09990	COG0067	glutamate synthase
HWV68_09990	COG0070	glutamate synthase
HWV68_09990	COG0069	glutamate synthase activity
HWV68_09995	COG0583	DNA-binding transcription factor activity
HWV68_10000	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HWV68_10005	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HWV68_10015	COG0300	oxidoreductase activity
HWV68_10020	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HWV68_10030	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWV68_10035	COG2814	Major facilitator Superfamily
HWV68_10040	COG1070	Carbohydrate kinase
HWV68_10045	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HWV68_10050	COG0243	molybdopterin cofactor binding
HWV68_10080	COG0840	transmembrane signaling receptor activity
HWV68_10080	COG5278	phosphoserine phosphatase activity
HWV68_10085	COG2368	4-hydroxyphenylacetate
HWV68_10090	COG4305	rare lipoprotein A
HWV68_10095	COG3619	membrane
HWV68_10100	COG3866	Pectate lyase
HWV68_10105	COG2135	peptidase activity
HWV68_10115	COG2140	Oxalate decarboxylase
HWV68_10130	COG0456	acetyltransferase
HWV68_10150	COG2720	vancomycin resistance protein
HWV68_10160	COG3655	Transcriptional regulator
HWV68_10165	COG3739	integral membrane protein
HWV68_10170	COG0583	DNA-binding transcription factor activity
HWV68_10175	COG0697	spore germination
HWV68_10185	COG0693	protein deglycase activity
HWV68_10190	COG2367	Beta-lactamase
HWV68_10205	COG0574	Belongs to the PEP-utilizing enzyme family
HWV68_10205	COG3848	Pyruvate phosphate dikinase
HWV68_10210	COG0726	polysaccharide deacetylase
HWV68_10215	COG2314	TM2 domain
HWV68_10220	COG1396	sequence-specific DNA binding
HWV68_10235	COG2135	peptidase activity
HWV68_10270	COG0457	Tetratricopeptide repeat
HWV68_10295	COG5290	Psort location Cytoplasmic, score
HWV68_10320	COG5444	nuclease activity
HWV68_10325	COG4282	regulation of fungal-type cell wall biogenesis
HWV68_10330	COG1231	oxidoreductase activity
HWV68_10335	COG5434	Belongs to the glycosyl hydrolase 28 family
HWV68_10340	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWV68_10345	COG0662	Cupin 2, conserved barrel domain protein
HWV68_10345	COG2207	Transcriptional regulator
HWV68_10350	COG0456	acetyltransferase
HWV68_10355	COG1309	transcriptional regulator
HWV68_10360	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWV68_10365	COG3708	Transcriptional regulator
HWV68_10370	COG2378	regulation of single-species biofilm formation
HWV68_10380	COG0640	Transcriptional regulator
HWV68_10385	COG0741	lytic transglycosylase activity
HWV68_10390	COG2322	membrane
HWV68_10405	COG1619	proteins homologs of microcin C7 resistance protein MccF
HWV68_10410	COG3239	Fatty acid desaturase
HWV68_10415	COG4585	Histidine kinase
HWV68_10420	COG2197	response regulator
HWV68_10425	COG1388	LysM domain
HWV68_10425	COG3584	3D domain protein
HWV68_10430	COG0514	ATP-dependent DNA helicase (RecQ)
HWV68_10440	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HWV68_10445	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HWV68_10460	COG0071	Belongs to the small heat shock protein (HSP20) family
HWV68_10485	COG1012	belongs to the aldehyde dehydrogenase family
HWV68_10490	COG1657	PFAM Prenyltransferase squalene oxidase
HWV68_10495	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HWV68_10500	COG0733	neurotransmitter:sodium symporter activity
HWV68_10505	COG0385	Bile acid
HWV68_10510	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWV68_10515	COG0567	Dehydrogenase, E1 component
HWV68_10520	COG4548	von Willebrand factor, type A
HWV68_10525	COG0714	Associated with various cellular activities
HWV68_10530	COG2032	superoxide dismutase activity
HWV68_10535	COG1388	LysM domain
HWV68_10535	COG0791	NLP P60 protein
HWV68_10540	COG1819	glycosyl
HWV68_10545	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
HWV68_10550	COG0534	Mate efflux family protein
HWV68_10555	COG1366	Belongs to the anti-sigma-factor antagonist family
HWV68_10560	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HWV68_10565	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HWV68_10575	COG2962	Rard protein
HWV68_10590	COG2610	gluconate transmembrane transporter activity
HWV68_10595	COG1942	4-Oxalocrotonate Tautomerase
HWV68_10600	COG1733	regulation of RNA biosynthetic process
HWV68_10605	COG0778	Nitroreductase
HWV68_10610	COG0400	carboxylic ester hydrolase activity
HWV68_10615	COG0346	lactoylglutathione lyase activity
HWV68_10625	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWV68_10630	COG0793	Belongs to the peptidase S41A family
HWV68_10630	COG3409	Peptidoglycan-binding domain 1 protein
HWV68_10635	COG2226	methyltransferase
HWV68_10645	COG1876	peptidase activity
HWV68_10650	COG0813	purine-nucleoside phosphorylase activity
HWV68_10665	COG0671	phosphoesterase, PA-phosphatase related
HWV68_10685	COG4479	Belongs to the UPF0346 family
HWV68_10695	COG1509	lysine 2,3-aminomutase activity
HWV68_10700	COG0456	acetyltransferase
HWV68_10705	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HWV68_10710	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HWV68_10715	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HWV68_10720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HWV68_10735	COG0456	acetyltransferase
HWV68_10740	COG0463	Glycosyl transferase, family 2
HWV68_10755	COG4641	Protein conserved in bacteria
HWV68_10760	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
HWV68_10765	COG1086	Polysaccharide biosynthesis protein
HWV68_10775	COG3331	DNA recombination
HWV68_10830	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HWV68_10865	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HWV68_10870	COG0756	dUTP diphosphatase activity
HWV68_10875	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWV68_10895	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HWV68_10895	COG1372	Participates in initiation and elongation during chromosome replication
HWV68_10900	COG1372	Participates in initiation and elongation during chromosome replication
HWV68_10900	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HWV68_10905	COG1780	Probably involved in ribonucleotide reductase function
HWV68_10995	COG0270	DNA (cytosine-5-)-methyltransferase activity
HWV68_11005	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
HWV68_11010	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HWV68_11035	COG3584	3D domain protein
HWV68_11040	COG0587	DNA-directed DNA polymerase activity
HWV68_11045	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HWV68_11050	COG0358	DNA primase activity
HWV68_11055	COG0305	Participates in initiation and elongation during chromosome replication
HWV68_11065	COG2887	Belongs to the helicase family. UvrD subfamily
HWV68_11095	COG3420	alginic acid biosynthetic process
HWV68_11095	COG5434	Belongs to the glycosyl hydrolase 28 family
HWV68_11100	COG4195	phage-related replication protein
HWV68_11115	COG2135	peptidase activity
HWV68_11120	COG1793	dna ligase
HWV68_11175	COG4474	Belongs to the UPF0398 family
HWV68_11185	COG1388	LysM domain
HWV68_11205	COG3645	SOS response
HWV68_11205	COG3646	Phage regulatory protein
HWV68_11260	COG3655	Transcriptional regulator
HWV68_11275	COG0582	viral genome integration into host DNA
HWV68_11355	COG3655	Transcriptional regulator
HWV68_11395	COG1395	domain, Protein
HWV68_11410	COG0776	regulation of translation
HWV68_11445	COG4373	Mu-like prophage FluMu protein gp28
HWV68_11545	COG0582	viral genome integration into host DNA
HWV68_11575	COG1196	nuclear chromosome segregation
HWV68_11575	COG0741	lytic transglycosylase activity
HWV68_11575	COG0739	heme binding
HWV68_11585	COG2433	Pfam Transposase IS66
HWV68_11595	COG5434	Belongs to the glycosyl hydrolase 28 family
HWV68_11595	COG4632	Exopolysaccharide biosynthesis protein
HWV68_11610	COG5632	N-Acetylmuramoyl-L-alanine amidase
HWV68_11625	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HWV68_11630	COG0463	Glycosyl transferase, family 2
HWV68_11635	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWV68_11640	COG3271	cysteine-type peptidase activity
HWV68_11640	COG2274	protein secretion by the type I secretion system
HWV68_11655	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HWV68_11685	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HWV68_11700	COG5444	nuclease activity
HWV68_11705	COG4282	regulation of fungal-type cell wall biogenesis
HWV68_11720	COG1525	nuclease
HWV68_11730	COG2746	aminoglycoside 3-N-acetyltransferase activity
HWV68_11755	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HWV68_11760	COG1086	Polysaccharide biosynthesis protein
HWV68_11765	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HWV68_11770	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HWV68_11775	COG1846	Transcriptional regulator
HWV68_11780	COG0534	Mate efflux family protein
HWV68_11790	COG4698	Protein conserved in bacteria
HWV68_11795	COG2755	lipolytic protein G-D-S-L family
HWV68_11800	COG1999	signal sequence binding
HWV68_11810	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HWV68_11815	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HWV68_11820	COG1272	protein, Hemolysin III
HWV68_11825	COG0204	Acyl-transferase
HWV68_11830	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HWV68_11835	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HWV68_11840	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HWV68_11850	COG2136	Putative SAM-dependent methyltransferase
HWV68_11850	COG2521	methyltransferase
HWV68_11860	COG0129	dihydroxy-acid dehydratase activity
HWV68_11865	COG1413	lyase activity
HWV68_11870	COG1418	mRNA catabolic process
HWV68_11875	COG0386	Belongs to the glutathione peroxidase family
HWV68_11880	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
HWV68_11885	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HWV68_11895	COG1278	Cold shock
HWV68_11915	COG0328	RNA-DNA hybrid ribonuclease activity
HWV68_11920	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HWV68_11925	COG0328	RNA-DNA hybrid ribonuclease activity
HWV68_11935	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HWV68_11950	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HWV68_11960	COG1755	Isoprenylcysteine carboxyl methyltransferase
HWV68_11965	COG3424	synthase
HWV68_11970	COG2233	PERMEase
HWV68_11975	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HWV68_11980	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
HWV68_11990	COG0800	Aldolase
HWV68_11995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWV68_12000	COG1609	Transcriptional regulator
HWV68_12005	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
HWV68_12010	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_12015	COG1199	ATP-dependent helicase activity
HWV68_12030	COG0116	Belongs to the methyltransferase superfamily
HWV68_12045	COG4474	Belongs to the UPF0398 family
HWV68_12060	COG3359	exonuclease
HWV68_12065	COG1111	helicase
HWV68_12065	COG1205	dead DEAH box helicase
HWV68_12070	COG2190	(PTS) system
HWV68_12075	COG0071	Belongs to the small heat shock protein (HSP20) family
HWV68_12110	COG3331	DNA recombination
HWV68_12115	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HWV68_12115	COG4499	WXG100 protein secretion system (Wss), protein YukC
HWV68_12125	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HWV68_12130	COG3935	DnaD domain protein
HWV68_12135	COG0017	Asparaginyl-tRNA synthetase
HWV68_12140	COG0436	Aminotransferase
HWV68_12145	COG5353	protein conserved in bacteria
HWV68_12155	COG1199	ATP-dependent helicase activity
HWV68_12155	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HWV68_12160	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
HWV68_12165	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HWV68_12170	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HWV68_12175	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HWV68_12175	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HWV68_12180	COG0617	tRNA 3'-terminal CCA addition
HWV68_12185	COG0438	transferase activity, transferring glycosyl groups
HWV68_12190	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HWV68_12195	COG1803	Methylglyoxal synthase
HWV68_12200	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HWV68_12205	COG1694	Mazg nucleotide pyrophosphohydrolase
HWV68_12210	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HWV68_12220	COG4347	Protein of unknown function (DUF1405)
HWV68_12225	COG2010	Cytochrome c
HWV68_12225	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HWV68_12230	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HWV68_12235	COG0723	plastoquinol--plastocyanin reductase activity
HWV68_12245	COG5582	Belongs to the UPF0302 family
HWV68_12250	COG0457	Tetratricopeptide repeat
HWV68_12255	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HWV68_12260	COG0287	Prephenate dehydrogenase
HWV68_12265	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HWV68_12270	COG0159	tryptophan synthase activity
HWV68_12275	COG0133	tryptophan synthase activity
HWV68_12280	COG0135	phosphoribosylanthranilate isomerase activity
HWV68_12290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HWV68_12295	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HWV68_12300	COG4401	Chorismate mutase type I
HWV68_12305	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HWV68_12310	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HWV68_12315	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HWV68_12320	COG0105	UTP biosynthetic process
HWV68_12325	COG0142	geranyltranstransferase activity
HWV68_12330	COG2226	methyltransferase
HWV68_12335	COG0142	geranyltranstransferase activity
HWV68_12345	COG0302	gtp cyclohydrolase
HWV68_12350	COG0776	regulation of translation
HWV68_12355	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HWV68_12370	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HWV68_12375	COG1160	GTP binding
HWV68_12400	COG1304	FMN binding
HWV68_12405	COG0539	negative regulation of cytoplasmic translation
HWV68_12410	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HWV68_12420	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HWV68_12425	COG2959	enzyme of heme biosynthesis
HWV68_12430	COG3773	Cell wall hydrolase
HWV68_12430	COG3409	Peptidoglycan-binding domain 1 protein
HWV68_12435	COG2339	peptidase activity
HWV68_12440	COG0492	ferredoxin-NADP+ reductase activity
HWV68_12445	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HWV68_12450	COG4862	establishment of competence for transformation
HWV68_12455	COG1408	metallophosphoesterase
HWV68_12465	COG1388	LysM domain
HWV68_12470	COG1266	CAAX protease self-immunity
HWV68_12475	COG0514	ATP-dependent DNA helicase (RecQ)
HWV68_12480	COG4955	Helix-turn-helix domain
HWV68_12485	COG1141	Ferredoxin
HWV68_12490	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
HWV68_12495	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HWV68_12500	COG0710	3-dehydroquinate dehydratase activity
HWV68_12510	COG1595	DNA-templated transcription, initiation
HWV68_12515	COG5002	protein histidine kinase activity
HWV68_12520	COG0745	RESPONSE REGULATOR receiver
HWV68_12525	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HWV68_12530	COG1333	cytochrome c biogenesis protein
HWV68_12535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWV68_12540	COG1187	pseudouridine synthase activity
HWV68_12545	COG0700	Nucleoside recognition
HWV68_12550	COG2715	membrane protein required for spore maturation
HWV68_12555	COG1686	Belongs to the peptidase S11 family
HWV68_12565	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HWV68_12570	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HWV68_12575	COG1547	Domain of unknown function (DUF309)
HWV68_12580	COG0456	acetyltransferase
HWV68_12585	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HWV68_12590	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HWV68_12590	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HWV68_12595	COG0307	riboflavin synthase, alpha
HWV68_12600	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HWV68_12600	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HWV68_12610	COG0681	Belongs to the peptidase S26 family
HWV68_12620	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
HWV68_12635	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HWV68_12640	COG4086	secreted protein
HWV68_12645	COG0019	diaminopimelate decarboxylase activity
HWV68_12650	COG0697	spore germination
HWV68_12665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HWV68_12685	COG1191	sigma factor activity
HWV68_12690	COG2172	sigma factor antagonist activity
HWV68_12695	COG1366	Belongs to the anti-sigma-factor antagonist family
HWV68_12700	COG1686	Belongs to the peptidase S11 family
HWV68_12705	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HWV68_12710	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HWV68_12715	COG4974	Belongs to the 'phage' integrase family
HWV68_12725	COG0735	belongs to the Fur family
HWV68_12730	COG1300	Membrane
HWV68_12740	COG0281	malic enzyme
HWV68_12745	COG1757	Na H antiporter
HWV68_12750	COG1027	Aspartate ammonia-lyase
HWV68_12755	COG0252	asparaginase activity
HWV68_12760	COG1396	sequence-specific DNA binding
HWV68_12765	COG1379	DNA repair
HWV68_12770	COG0494	nUDIX hydrolase
HWV68_12780	COG0667	Aldo Keto reductase
HWV68_12790	COG1073	alpha beta
HWV68_12800	COG4918	Iron-sulphur cluster biosynthesis
HWV68_12805	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
HWV68_12805	COG0456	acetyltransferase
HWV68_12810	COG2329	Antibiotic biosynthesis monooxygenase
HWV68_12815	COG0456	acetyltransferase
HWV68_12825	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HWV68_12835	COG2211	Major facilitator Superfamily
HWV68_12845	COG0346	lactoylglutathione lyase activity
HWV68_12850	COG1072	(Pantothenic acid kinase))
HWV68_12855	COG3048	D-serine ammonia-lyase activity
HWV68_12860	COG0300	oxidoreductase activity
HWV68_12865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWV68_12870	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HWV68_12875	COG4187	Peptidase family M20/M25/M40
HWV68_12880	COG1902	pentaerythritol trinitrate reductase activity
HWV68_12885	COG0596	Alpha beta hydrolase
HWV68_12895	COG1234	tRNA 3'-trailer cleavage
HWV68_12900	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HWV68_12905	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HWV68_12910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HWV68_12920	COG0706	membrane insertase activity
HWV68_12925	COG3361	conserved protein (COG2071)
HWV68_12930	COG2195	Cleaves the N-terminal amino acid of tripeptides
HWV68_12935	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HWV68_12940	COG0346	lactoylglutathione lyase activity
HWV68_12950	COG1376	ErfK ybiS ycfS ynhG family protein
HWV68_12955	COG4129	membrane
HWV68_12960	COG1126	abc transporter atp-binding protein
HWV68_12965	COG0765	amino acid transport
HWV68_12970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWV68_12980	COG1597	lipid kinase activity
HWV68_12985	COG2814	Major facilitator Superfamily
HWV68_12990	COG0789	Transcriptional regulator
HWV68_12990	COG4978	Transcriptional regulator
HWV68_12995	COG0508	dehydrogenase complex catalyzes the overall conversion of
HWV68_13000	COG0022	dehydrogenase e1 component
HWV68_13005	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HWV68_13010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HWV68_13015	COG3426	butyrate kinase activity
HWV68_13020	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HWV68_13025	COG0280	phosphate acetyltransferase
HWV68_13030	COG3829	transcription factor binding
HWV68_13030	COG3290	protein histidine kinase activity
HWV68_13040	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HWV68_13045	COG2079	MmgE PrpD family protein
HWV68_13050	COG0372	Belongs to the citrate synthase family
HWV68_13055	COG1960	acyl-CoA dehydrogenase activity
HWV68_13060	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWV68_13065	COG0183	Belongs to the thiolase family
HWV68_13070	COG0584	glycerophosphoryl diester phosphodiesterase
HWV68_13075	COG0860	N-Acetylmuramoyl-L-alanine amidase
HWV68_13090	COG1902	pentaerythritol trinitrate reductase activity
HWV68_13095	COG0745	RESPONSE REGULATOR receiver
HWV68_13100	COG0750	zinc metalloprotease
HWV68_13105	COG0497	DNA recombination
HWV68_13110	COG1438	arginine binding
HWV68_13115	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HWV68_13120	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HWV68_13125	COG0142	geranyltranstransferase activity
HWV68_13130	COG1722	exodeoxyribonuclease VII activity
HWV68_13135	COG1570	exodeoxyribonuclease VII activity
HWV68_13140	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HWV68_13145	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HWV68_13150	COG1302	Protein conserved in bacteria
HWV68_13155	COG0439	Biotin carboxylase
HWV68_13160	COG0511	ligase activity, forming carbon-carbon bonds
HWV68_13200	COG3854	ATPases associated with a variety of cellular activities
HWV68_13210	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HWV68_13215	COG0006	proline dipeptidase activity
HWV68_13220	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
HWV68_13230	COG3872	metal-dependent enzyme
HWV68_13240	COG1752	Esterase of the alpha-beta hydrolase superfamily
HWV68_13245	COG1321	iron dependent repressor
HWV68_13250	COG0095	Lipoate-protein ligase
HWV68_13255	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HWV68_13260	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HWV68_13265	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HWV68_13270	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HWV68_13275	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HWV68_13290	COG1396	sequence-specific DNA binding
HWV68_13300	COG0681	Belongs to the peptidase S26 family
HWV68_13325	COG4940	Competence protein ComGF
HWV68_13335	COG4970	Tfp pilus assembly protein FimT
HWV68_13340	COG4537	Required for transformation and DNA binding
HWV68_13345	COG1459	type II secretion system
HWV68_13350	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HWV68_13355	COG0598	Magnesium transport protein CorA
HWV68_13360	COG1253	flavin adenine dinucleotide binding
HWV68_13365	COG1366	Belongs to the anti-sigma-factor antagonist family
HWV68_13375	COG1393	Belongs to the ArsC family
HWV68_13385	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWV68_13395	COG0011	TIGRFAM Protein of
HWV68_13405	COG2866	Carboxypeptidase
HWV68_13410	COG1368	sulfuric ester hydrolase activity
HWV68_13415	COG1940	carbohydrate kinase activity
HWV68_13420	COG4483	Protein conserved in bacteria
HWV68_13425	COG0457	Tetratricopeptide repeat
HWV68_13425	COG0705	Rhomboid family
HWV68_13435	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HWV68_13445	COG0438	transferase activity, transferring glycosyl groups
HWV68_13460	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HWV68_13465	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HWV68_13470	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HWV68_13475	COG0581	inorganic phosphate transmembrane transporter activity
HWV68_13480	COG0573	inorganic phosphate transmembrane transporter activity
HWV68_13485	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HWV68_13495	COG0477	Major facilitator Superfamily
HWV68_13500	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HWV68_13505	COG2839	Protein conserved in bacteria
HWV68_13510	COG5521	maltodextrose utilization protein MalA
HWV68_13520	COG1388	LysM domain
HWV68_13525	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HWV68_13530	COG4709	membrane
HWV68_13535	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
HWV68_13540	COG0735	belongs to the Fur family
HWV68_13545	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HWV68_13555	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
HWV68_13560	COG0513	Belongs to the DEAD box helicase family
HWV68_13570	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HWV68_13575	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HWV68_13580	COG2384	SAM-dependent methyltransferase
HWV68_13585	COG2010	Cytochrome c
HWV68_13590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HWV68_13595	COG0358	DNA primase activity
HWV68_13600	COG1671	Belongs to the UPF0178 family
HWV68_13605	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HWV68_13610	COG0517	IMP dehydrogenase activity
HWV68_13615	COG0751	glycine-tRNA ligase activity
HWV68_13620	COG0752	glycyl-tRNA synthetase alpha subunit
HWV68_13625	COG1381	Involved in DNA repair and RecF pathway recombination
HWV68_13635	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HWV68_13640	COG0295	cytidine deaminase activity
HWV68_13645	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HWV68_13650	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HWV68_13655	COG1480	7TM receptor with intracellular HD hydrolase
HWV68_13660	COG1702	phosphate starvation-inducible protein PhoH
HWV68_13665	COG0561	phosphatase activity
HWV68_13680	COG4864	UPF0365 protein
HWV68_13685	COG1030	water channel activity
HWV68_13690	COG1610	YqeY-like protein
HWV68_13700	COG1283	sodium-dependent phosphate transmembrane transporter activity
HWV68_13705	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HWV68_13710	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HWV68_13715	COG2264	protein methyltransferase activity
HWV68_13720	COG0484	heat shock protein binding
HWV68_13725	COG0443	Heat shock 70 kDa protein
HWV68_13730	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HWV68_13735	COG1420	regulation of RNA biosynthetic process
HWV68_13740	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HWV68_13745	COG0481	GTPase activity
HWV68_13755	COG0860	N-Acetylmuramoyl-L-alanine amidase
HWV68_13760	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HWV68_13765	COG0268	Binds directly to 16S ribosomal RNA
HWV68_13770	COG1466	dna polymerase III delta subunit
HWV68_13785	COG0658	competence protein
HWV68_13785	COG2333	competence protein COMEC
HWV68_13790	COG2131	deaminase
HWV68_13795	COG1555	photosystem II stabilization
HWV68_13795	COG1596	polysaccharide export
HWV68_13800	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HWV68_13805	COG2226	methyltransferase
HWV68_13810	COG0799	negative regulation of ribosome biogenesis
HWV68_13815	COG1713	HD superfamily hydrolase involved in NAD metabolism
HWV68_13820	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HWV68_13825	COG1534	Rna-binding protein
HWV68_13830	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HWV68_13835	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
HWV68_13840	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
HWV68_13850	COG2755	lipolytic protein G-D-S-L family
HWV68_13855	COG3409	Peptidoglycan-binding domain 1 protein
HWV68_13855	COG5632	N-Acetylmuramoyl-L-alanine amidase
HWV68_13860	COG0398	Pfam SNARE associated Golgi protein
HWV68_13865	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
HWV68_13875	COG3209	COG3209 Rhs family protein
HWV68_13885	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HWV68_13890	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HWV68_13895	COG0798	PFAM Bile acid sodium symporter
HWV68_13900	COG0346	lactoylglutathione lyase activity
HWV68_13905	COG0640	Transcriptional regulator
HWV68_13910	COG3403	YqcI/YcgG family
HWV68_13915	COG0457	Tetratricopeptide repeat
HWV68_13930	COG5444	nuclease activity
HWV68_13955	COG5632	N-Acetylmuramoyl-L-alanine amidase
HWV68_13955	COG3409	Peptidoglycan-binding domain 1 protein
HWV68_13960	COG4824	toxin secretion phage lysis holin
HWV68_13990	COG3778	Protein conserved in bacteria
HWV68_13995	COG3299	homolog of phage Mu protein gp47
HWV68_14000	COG3628	GPW Gp25 family protein
HWV68_14010	COG4193	domain, Protein
HWV68_14015	COG1652	LysM domain
HWV68_14020	COG3953	SLT domain
HWV68_14020	COG5280	Phage tail tape measure protein TP901
HWV68_14085	COG4653	Phage capsid family
HWV68_14090	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HWV68_14100	COG2369	cell adhesion
HWV68_14105	COG5518	Phage portal protein
HWV68_14110	COG1783	phage Terminase large subunit
HWV68_14115	COG5484	DNA packaging
HWV68_14125	COG3677	Transposase
HWV68_14140	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HWV68_14150	COG1484	DNA-dependent DNA replication
HWV68_14155	COG3935	DnaD domain protein
HWV68_14160	COG3723	Recombinational DNA repair protein, rece pathway
HWV68_14165	COG5377	YqaJ viral recombinase family
HWV68_14195	COG1476	TRANSCRIPTIONal
HWV68_14200	COG3620	sequence-specific DNA binding
HWV68_14210	COG0563	adenylate kinase activity
HWV68_14215	COG2856	Zn peptidase
HWV68_14240	COG3223	Belongs to the PsiE family
HWV68_14245	COG5002	protein histidine kinase activity
HWV68_14245	COG0642	Histidine kinase
HWV68_14250	COG0745	RESPONSE REGULATOR receiver
HWV68_14255	COG2311	Membrane
HWV68_14265	COG0454	-acetyltransferase
HWV68_14270	COG2249	NAD(P)H dehydrogenase (quinone) activity
HWV68_14280	COG0730	response to heat
HWV68_14285	COG0425	Belongs to the sulfur carrier protein TusA family
HWV68_14290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWV68_14290	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HWV68_14300	COG0425	Belongs to the sulfur carrier protein TusA family
HWV68_14300	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HWV68_14305	COG2210	Belongs to the sulfur carrier protein TusA family
HWV68_14310	COG1937	Protein conserved in bacteria
HWV68_14315	COG0662	Cupin 2, conserved barrel domain protein
HWV68_14325	COG4978	Transcriptional regulator
HWV68_14325	COG0789	Transcriptional regulator
HWV68_14330	COG2814	Major facilitator Superfamily
HWV68_14335	COG0456	acetyltransferase
HWV68_14340	COG1253	flavin adenine dinucleotide binding
HWV68_14350	COG0697	spore germination
HWV68_14355	COG0583	DNA-binding transcription factor activity
HWV68_14360	COG2072	flavoprotein involved in K transport
HWV68_14365	COG1230	cation diffusion facilitator family transporter
HWV68_14370	COG1942	4-Oxalocrotonate Tautomerase
HWV68_14375	COG0583	DNA-binding transcription factor activity
HWV68_14385	COG1114	Component of the transport system for branched-chain amino acids
HWV68_14390	COG1687	branched-chain amino acid
HWV68_14395	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HWV68_14400	COG1522	sequence-specific DNA binding
HWV68_14405	COG2732	(Barnase) inhibitor
HWV68_14410	COG2124	cytochrome p450
HWV68_14420	COG1335	isochorismatase
HWV68_14435	COG2318	DinB family
HWV68_14445	COG2070	2-Nitropropane dioxygenase
HWV68_14450	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HWV68_14470	COG3443	Belongs to the bacterial solute-binding protein 9 family
HWV68_14475	COG1595	DNA-templated transcription, initiation
HWV68_14480	COG0667	Aldo Keto reductase
HWV68_14485	COG2851	Citrate transporter
HWV68_14490	COG0583	DNA-binding transcription factor activity
HWV68_14495	COG2828	Protein conserved in bacteria
HWV68_14500	COG3409	Peptidoglycan-binding domain 1 protein
HWV68_14505	COG5566	PFAM Mor transcription activator
HWV68_14510	COG0596	Alpha beta hydrolase
HWV68_14515	COG4991	sh3 domain protein
HWV68_14520	COG4991	sh3 domain protein
HWV68_14530	COG0346	lactoylglutathione lyase activity
HWV68_14540	COG5577	PFAM Coat F domain
HWV68_14545	COG1063	alcohol dehydrogenase
HWV68_14555	COG5577	PFAM Coat F domain
HWV68_14560	COG0789	Transcriptional regulator
HWV68_14570	COG1064	alcohol dehydrogenase
HWV68_14575	COG0693	protein deglycase activity
HWV68_14580	COG1621	beta-fructofuranosidase activity
HWV68_14585	COG3716	PTS system mannose fructose sorbose family IID component
HWV68_14590	COG3715	PTS system
HWV68_14595	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWV68_14600	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWV68_14605	COG3933	PFAM sigma-54 factor interaction domain-containing protein
HWV68_14605	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HWV68_14615	COG1113	amino acid transport
HWV68_14620	COG1280	lysine exporter protein (LysE YggA)
HWV68_14625	COG1378	Sugar-specific transcriptional regulator TrmB
HWV68_14630	COG1595	DNA-templated transcription, initiation
HWV68_14640	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
HWV68_14640	COG2755	lipolytic protein G-D-S-L family
HWV68_14650	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HWV68_14650	COG2124	cytochrome p450
HWV68_14655	COG1309	transcriptional regulator
HWV68_14660	COG2226	methyltransferase
HWV68_14675	COG2116	formate transmembrane transporter activity
HWV68_14680	COG5609	conserved protein (DUF2294)
HWV68_14685	COG3383	formate dehydrogenase (NAD+) activity
HWV68_14690	COG2427	Protein of unknown function (DUF1641)
HWV68_14700	COG0626	cystathionine gamma-synthase activity
HWV68_14705	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HWV68_14710	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HWV68_14715	COG2226	methyltransferase
HWV68_14730	COG0768	penicillin binding
HWV68_14735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HWV68_14740	COG0572	uridine kinase
HWV68_14755	COG4122	O-methyltransferase activity
HWV68_14760	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HWV68_14765	COG3906	Belongs to the UPF0473 family
HWV68_14770	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HWV68_14775	COG4472	Bacterial protein of unknown function (DUF965)
HWV68_14780	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HWV68_14785	COG0628	permease
HWV68_14790	COG1126	abc transporter atp-binding protein
HWV68_14795	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWV68_14800	COG0765	amino acid transport
HWV68_14805	COG0765	amino acid transport
HWV68_14820	COG3881	PFAM PRC-barrel domain
HWV68_14825	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HWV68_14830	COG0457	Tetratricopeptide repeat
HWV68_14835	COG0482	sulfurtransferase activity
HWV68_14840	COG1104	cysteine desulfurase activity
HWV68_14845	COG1959	2 iron, 2 sulfur cluster binding
HWV68_14850	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HWV68_14855	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HWV68_14865	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HWV68_14870	COG0124	histidyl-tRNA synthetase
HWV68_14880	COG0860	N-Acetylmuramoyl-L-alanine amidase
HWV68_14880	COG3103	Sh3 type 3 domain protein
HWV68_14880	COG4991	sh3 domain protein
HWV68_14885	COG1490	D-aminoacyl-tRNA deacylase activity
HWV68_14890	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HWV68_14895	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HWV68_14900	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
HWV68_14900	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HWV68_14905	COG5416	Lipopolysaccharide assembly protein A domain
HWV68_14910	COG0490	domain, Protein
HWV68_14915	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HWV68_14915	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HWV68_14925	COG2244	polysaccharide biosynthetic process
HWV68_14930	COG2323	membrane
HWV68_14940	COG1862	Preprotein translocase
HWV68_14945	COG0343	queuine tRNA-ribosyltransferase activity
HWV68_14950	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HWV68_14960	COG2255	four-way junction helicase activity
HWV68_14965	COG0632	four-way junction helicase activity
HWV68_14975	COG2814	Major facilitator Superfamily
HWV68_14980	COG0673	inositol 2-dehydrogenase activity
HWV68_14985	COG2112	serine threonine protein kinase
HWV68_15005	COG1115	amino acid carrier protein
HWV68_15010	COG0217	transcriptional regulatory protein
HWV68_15020	COG1388	LysM domain
HWV68_15025	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
HWV68_15030	COG0157	Belongs to the NadC ModD family
HWV68_15035	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HWV68_15040	COG1104	cysteine desulfurase activity
HWV68_15045	COG1827	regulation of RNA biosynthetic process
HWV68_15050	COG0077	Prephenate dehydratase
HWV68_15055	COG4492	Belongs to the UPF0735 family
HWV68_15060	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HWV68_15065	COG3290	protein histidine kinase activity
HWV68_15075	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HWV68_15080	COG2868	ribosomal protein
HWV68_15085	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HWV68_15090	COG1994	Peptidase M50
HWV68_15095	COG0739	heme binding
HWV68_15100	COG2894	cell division
HWV68_15105	COG0850	regulation of cytokinetic process
HWV68_15110	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HWV68_15120	COG1077	Cell shape determining protein MreB Mrl
HWV68_15125	COG2003	Belongs to the UPF0758 family
HWV68_15130	COG0424	maF-like protein
HWV68_15140	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HWV68_15145	COG0285	dihydrofolate synthase activity
HWV68_15150	COG0525	valine-tRNA ligase activity
HWV68_15160	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HWV68_15165	COG1388	LysM domain
HWV68_15170	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HWV68_15175	COG0113	porphobilinogen synthase activity
HWV68_15180	COG1587	Uroporphyrinogen-III synthase
HWV68_15185	COG0181	hydroxymethylbilane synthase activity
HWV68_15190	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HWV68_15195	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
HWV68_15205	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HWV68_15210	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HWV68_15215	COG0470	DNA polymerase III
HWV68_15215	COG1067	ATP-dependent peptidase activity
HWV68_15220	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HWV68_15225	COG0544	peptidyl-prolyl cis-trans isomerase activity
HWV68_15230	COG1477	protein flavinylation
HWV68_15230	COG0457	Tetratricopeptide repeat
HWV68_15235	COG0066	3-isopropylmalate dehydratase activity
HWV68_15240	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HWV68_15245	COG0473	3-isopropylmalate dehydrogenase activity
HWV68_15250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HWV68_15255	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HWV68_15260	COG0440	acetolactate synthase activity
HWV68_15265	COG0028	Belongs to the TPP enzyme family
HWV68_15275	COG0454	-acetyltransferase
HWV68_15280	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
HWV68_15290	COG0622	Phosphoesterase
HWV68_15295	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HWV68_15300	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HWV68_15305	COG5401	PFAM Sporulation and spore germination
HWV68_15310	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HWV68_15315	COG1846	Transcriptional regulator
HWV68_15320	COG2197	response regulator
HWV68_15325	COG0824	Thioesterase
HWV68_15330	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HWV68_15335	COG1053	succinate dehydrogenase
HWV68_15340	COG2009	succinate dehydrogenase
HWV68_15345	COG1719	4-vinyl reductase, 4VR
HWV68_15350	COG0527	aspartate kinase activity
HWV68_15355	COG0322	excinuclease ABC activity
HWV68_15360	COG3118	belongs to the thioredoxin family
HWV68_15365	COG3534	alpha-L-arabinofuranosidase
HWV68_15370	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HWV68_15375	COG2086	electron transfer activity
HWV68_15380	COG1024	Enoyl-CoA hydratase
HWV68_15385	COG1309	transcriptional regulator
HWV68_15390	COG0318	PFAM AMP-dependent synthetase and ligase
HWV68_15395	COG3766	membrane
HWV68_15400	COG1193	negative regulation of DNA recombination
HWV68_15405	COG1796	DNA polymerase
HWV68_15405	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HWV68_15410	COG1286	toxin biosynthetic process
HWV68_15415	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
HWV68_15420	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HWV68_15425	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWV68_15425	COG0072	phenylalanine-tRNA ligase activity
HWV68_15430	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HWV68_15440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HWV68_15450	COG3835	regulator
HWV68_15455	COG0277	FAD linked oxidase domain protein
HWV68_15460	COG0247	lactate metabolic process
HWV68_15465	COG0346	lactoylglutathione lyase activity
HWV68_15475	COG1966	Carbon starvation protein
HWV68_15480	COG3534	alpha-L-arabinofuranosidase
HWV68_15485	COG0395	ABC-type sugar transport system, permease component
HWV68_15490	COG1175	transmembrane transport
HWV68_15495	COG1653	transport
HWV68_15500	COG0371	Dehydrogenase
HWV68_15505	COG0647	UMP catabolic process
HWV68_15510	COG0235	Class ii aldolase
HWV68_15515	COG1069	ribulokinase activity
HWV68_15520	COG2160	L-arabinose isomerase activity
HWV68_15525	COG3507	Belongs to the glycosyl hydrolase 43 family
HWV68_15530	COG1363	Peptidase, m42
HWV68_15540	COG3326	Membrane
HWV68_15545	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HWV68_15550	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HWV68_15555	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HWV68_15565	COG1346	cytolysis
HWV68_15570	COG1380	Effector of murein hydrolase LrgA
HWV68_15575	COG3279	Response regulator of the LytR AlgR family
HWV68_15580	COG3275	phosphorelay sensor kinase activity
HWV68_15585	COG1011	Hydrolase
HWV68_15590	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HWV68_15600	COG0398	Pfam SNARE associated Golgi protein
HWV68_15605	COG1484	DNA-dependent DNA replication
HWV68_15610	COG3611	Membrane attachment protein
HWV68_15615	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HWV68_15620	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
HWV68_15625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HWV68_15630	COG1733	regulation of RNA biosynthetic process
HWV68_15635	COG2814	Major facilitator Superfamily
HWV68_15640	COG0656	L-ascorbic acid biosynthetic process
HWV68_15645	COG0237	dephospho-CoA kinase activity
HWV68_15650	COG1971	Probably functions as a manganese efflux pump
HWV68_15655	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HWV68_15660	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HWV68_15660	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HWV68_15665	COG5002	protein histidine kinase activity
HWV68_15670	COG0745	RESPONSE REGULATOR receiver
HWV68_15675	COG0039	L-malate dehydrogenase activity
HWV68_15680	COG0538	isocitrate dehydrogenase activity
HWV68_15685	COG0372	Belongs to the citrate synthase family
HWV68_15690	COG2707	UPF0756 membrane protein
HWV68_15695	COG0628	permease
HWV68_15700	COG3030	protein affecting phage T7 exclusion by the F plasmid
HWV68_15705	COG0469	pyruvate kinase activity
HWV68_15710	COG0205	6-phosphofructokinase activity
HWV68_15715	COG0825	malonyl-CoA metabolic process
HWV68_15720	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HWV68_15725	COG0281	malic enzyme
HWV68_15730	COG0587	DNA-directed DNA polymerase activity
HWV68_15750	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
HWV68_15760	COG4109	DRTGG domain
HWV68_15765	COG0730	response to heat
HWV68_15770	COG1473	amidohydrolase
HWV68_15775	COG0196	riboflavin kinase activity
HWV68_15780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWV68_15785	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HWV68_15790	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWV68_15795	COG1126	abc transporter atp-binding protein
HWV68_15800	COG0765	amino acid transport
HWV68_15805	COG0765	amino acid transport
HWV68_15810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWV68_15815	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWV68_15820	COG0454	-acetyltransferase
HWV68_15825	COG0583	DNA-binding transcription factor activity
HWV68_15830	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HWV68_15835	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_15840	COG0165	Argininosuccinate lyase
HWV68_15845	COG0137	argininosuccinate synthase activity
HWV68_15850	COG0521	Mo-molybdopterin cofactor biosynthetic process
HWV68_15855	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HWV68_15865	COG0827	DNA restriction-modification system
HWV68_15870	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HWV68_15875	COG3874	Sporulation protein YtfJ
HWV68_15885	COG1714	RDD family
HWV68_15890	COG0616	signal peptide processing
HWV68_15895	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HWV68_15900	COG1574	metal-dependent hydrolase with the TIM-barrel fold
HWV68_15905	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HWV68_15915	COG0301	tRNA thio-modification
HWV68_15920	COG1104	cysteine desulfurase activity
HWV68_15925	COG1114	Component of the transport system for branched-chain amino acids
HWV68_15930	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
HWV68_15935	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
HWV68_15940	COG1309	transcriptional regulator
HWV68_15945	COG1956	GAF domain-containing protein
HWV68_15950	COG2203	Gaf domain
HWV68_15950	COG2199	diguanylate cyclase activity
HWV68_15955	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HWV68_15960	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HWV68_15965	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HWV68_15970	COG0454	-acetyltransferase
HWV68_15975	COG0517	IMP dehydrogenase activity
HWV68_15980	COG0123	including yeast histone deacetylase and acetoin utilization protein
HWV68_15985	COG1360	Flagellar Motor Protein
HWV68_15990	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HWV68_15995	COG1609	Transcriptional regulator
HWV68_16000	COG1605	Chorismate mutase
HWV68_16000	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
HWV68_16005	COG3118	belongs to the thioredoxin family
HWV68_16010	COG4980	gas vesicle protein
HWV68_16015	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
HWV68_16020	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HWV68_16025	COG1674	ftsk spoiiie
HWV68_16030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HWV68_16035	COG4848	Belongs to the UPF0354 family
HWV68_16040	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWV68_16055	COG1363	Peptidase, m42
HWV68_16060	COG5584	Small secreted protein
HWV68_16065	COG0281	malic enzyme
HWV68_16070	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWV68_16075	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HWV68_16085	COG0510	thiamine kinase activity
HWV68_16090	COG1523	belongs to the glycosyl hydrolase 13 family
HWV68_16095	COG1597	lipid kinase activity
HWV68_16105	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HWV68_16110	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HWV68_16115	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HWV68_16120	COG2252	PERMEase
HWV68_16125	COG4473	ABC transporter
HWV68_16130	COG1131	(ABC) transporter
HWV68_16135	COG1349	DNA-binding transcription factor activity
HWV68_16140	COG1187	pseudouridine synthase activity
HWV68_16145	COG2244	polysaccharide biosynthetic process
HWV68_16150	COG2081	HI0933 family
HWV68_16155	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HWV68_16165	COG5578	integral membrane protein
HWV68_16170	COG0673	inositol 2-dehydrogenase activity
HWV68_16175	COG1653	transport
HWV68_16180	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
HWV68_16185	COG4209	transmembrane transport
HWV68_16190	COG2207	Transcriptional regulator
HWV68_16195	COG1653	transport
HWV68_16200	COG0395	ABC-type sugar transport system, permease component
HWV68_16205	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HWV68_16210	COG2124	cytochrome p450
HWV68_16215	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HWV68_16220	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HWV68_16225	COG0156	8-amino-7-oxononanoate synthase activity
HWV68_16230	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HWV68_16235	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
HWV68_16240	COG1073	alpha beta
HWV68_16245	COG1609	Transcriptional regulator
HWV68_16250	COG1653	transport
HWV68_16255	COG1175	transmembrane transport
HWV68_16260	COG0395	ABC-type sugar transport system, permease component
HWV68_16265	COG1486	melibiose metabolic process
HWV68_16270	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HWV68_16275	COG0495	leucyl-tRNA aminoacylation
HWV68_16285	COG1366	Belongs to the anti-sigma-factor antagonist family
HWV68_16285	COG2202	Pas domain
HWV68_16290	COG2814	Major facilitator Superfamily
HWV68_16295	COG2433	Pfam Transposase IS66
HWV68_16300	COG0577	efflux transmembrane transporter activity
HWV68_16305	COG1136	(ABC) transporter
HWV68_16310	COG2205	protein histidine kinase activity
HWV68_16315	COG0745	RESPONSE REGULATOR receiver
HWV68_16320	COG0577	efflux transmembrane transporter activity
HWV68_16325	COG1136	(ABC) transporter
HWV68_16340	COG1131	(ABC) transporter
HWV68_16345	COG1725	Transcriptional regulator
HWV68_16360	COG1242	4 iron, 4 sulfur cluster binding
HWV68_16365	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HWV68_16375	COG2267	carboxylic ester hydrolase activity
HWV68_16380	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HWV68_16385	COG1113	amino acid transport
HWV68_16390	COG0367	asparagine synthase
HWV68_16395	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HWV68_16400	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HWV68_16410	COG1506	peptidase
HWV68_16415	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HWV68_16420	COG1116	anion transmembrane transporter activity
HWV68_16425	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HWV68_16430	COG0494	nUDIX hydrolase
HWV68_16435	COG4824	toxin secretion phage lysis holin
HWV68_16440	COG0783	Belongs to the Dps family
HWV68_16455	COG1854	S-ribosylhomocysteine lyase activity
HWV68_16460	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HWV68_16465	COG0288	reversible hydration of carbon dioxide
HWV68_16470	COG0254	rRNA binding
HWV68_16475	COG1271	oxidase subunit
HWV68_16480	COG1294	oxidase, subunit
HWV68_16490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HWV68_16495	COG1321	iron dependent repressor
HWV68_16495	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HWV68_16500	COG1121	(ABC) transporter
HWV68_16505	COG0803	Belongs to the bacterial solute-binding protein 9 family
HWV68_16510	COG4948	Mandelate Racemase Muconate Lactonizing
HWV68_16515	COG0318	PFAM AMP-dependent synthetase and ligase
HWV68_16520	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HWV68_16525	COG0596	Alpha beta hydrolase
HWV68_16530	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
HWV68_16535	COG1169	isochorismate synthase
HWV68_16540	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HWV68_16545	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HWV68_16550	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HWV68_16555	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HWV68_16560	COG0438	transferase activity, transferring glycosyl groups
HWV68_16570	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HWV68_16575	COG0438	transferase activity, transferring glycosyl groups
HWV68_16580	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HWV68_16585	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
HWV68_16590	COG0058	SHG alpha-glucan phosphorylase activity
HWV68_16595	COG0297	glycogen (starch) synthase activity
HWV68_16600	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HWV68_16605	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
HWV68_16610	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HWV68_16735	COG3859	Proton-coupled thiamine transporter YuaJ
HWV68_16740	COG1247	-acetyltransferase
HWV68_16745	COG2268	Band 7 protein
HWV68_16750	COG1585	Membrane protein implicated in regulation of membrane protease activity
HWV68_16755	COG2318	DinB family
HWV68_16765	COG1454	alcohol dehydrogenase
HWV68_16770	COG1012	belongs to the aldehyde dehydrogenase family
HWV68_16775	COG1510	regulation of RNA biosynthetic process
HWV68_16785	COG0569	domain protein
HWV68_16790	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HWV68_16795	COG4682	membrane
HWV68_16800	COG1705	Flagellar rod assembly protein muramidase FlgJ
HWV68_16805	COG0477	Major facilitator Superfamily
HWV68_16810	COG5553	Cysteine dioxygenase type I
HWV68_16820	COG1968	undecaprenyl-diphosphatase activity
HWV68_16825	COG0628	permease
HWV68_16830	COG0673	inositol 2-dehydrogenase activity
HWV68_16835	COG4806	L-rhamnose isomerase
HWV68_16840	COG3254	rhamnose metabolic process
HWV68_16845	COG1070	Carbohydrate kinase
HWV68_16850	COG1349	DNA-binding transcription factor activity
HWV68_16855	COG3347	Dehydrogenase
HWV68_16855	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_16860	COG0840	transmembrane signaling receptor activity
HWV68_16865	COG0840	transmembrane signaling receptor activity
HWV68_16870	COG0840	transmembrane signaling receptor activity
HWV68_16875	COG0840	transmembrane signaling receptor activity
HWV68_16890	COG0432	Pfam Uncharacterised protein family UPF0047
HWV68_16900	COG0366	Alpha amylase catalytic
HWV68_16905	COG1253	flavin adenine dinucleotide binding
HWV68_16910	COG2738	Putative neutral zinc metallopeptidase
HWV68_16925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HWV68_16940	COG0166	Belongs to the GPI family
HWV68_16945	COG1979	alcohol dehydrogenase
HWV68_16950	COG1979	alcohol dehydrogenase
HWV68_16955	COG2155	Conserved Protein
HWV68_16960	COG1098	S1 RNA binding domain
HWV68_16965	COG0436	Aminotransferase
HWV68_16970	COG1522	sequence-specific DNA binding
HWV68_16975	COG2267	carboxylic ester hydrolase activity
HWV68_16985	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HWV68_16990	COG2205	protein histidine kinase activity
HWV68_17000	COG5018	Exonuclease
HWV68_17005	COG2814	Major facilitator Superfamily
HWV68_17010	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HWV68_17015	COG3011	Protein conserved in bacteria
HWV68_17025	COG3290	protein histidine kinase activity
HWV68_17030	COG4565	transcriptional regulatory protein
HWV68_17055	COG3493	citrate carrier protein
HWV68_17065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HWV68_17065	COG2111	Na H antiporter
HWV68_17070	COG2111	Na H antiporter
HWV68_17075	COG1006	Multisubunit Na H antiporter MnhC subunit
HWV68_17080	COG0651	ATP synthesis coupled electron transport
HWV68_17085	COG1863	multisubunit Na H antiporter MnhE subunit
HWV68_17090	COG2212	antiporter activity
HWV68_17095	COG1320	monovalent cation:proton antiporter activity
HWV68_17100	COG2050	protein possibly involved in aromatic compounds catabolism
HWV68_17105	COG2197	response regulator
HWV68_17110	COG4585	Histidine kinase
HWV68_17120	COG0142	geranyltranstransferase activity
HWV68_17140	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
HWV68_17145	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
HWV68_17150	COG1335	isochorismatase
HWV68_17155	COG5506	Protein of unknown function (DUF1694)
HWV68_17170	COG0628	permease
HWV68_17185	COG1418	mRNA catabolic process
HWV68_17190	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_17200	COG1511	domain protein
HWV68_17205	COG0433	COG0433 Predicted ATPase
HWV68_17205	COG1674	ftsk spoiiie
HWV68_17210	COG4499	WXG100 protein secretion system (Wss), protein YukC
HWV68_17215	COG5417	Belongs to the EsaB family
HWV68_17220	COG4842	Belongs to the WXG100 family
HWV68_17225	COG2508	Transcriptional regulator
HWV68_17225	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
HWV68_17230	COG0686	Belongs to the AlaDH PNT family
HWV68_17235	COG5634	Uncharacterized conserved protein (DUF2278)
HWV68_17240	COG3251	PFAM MbtH domain protein
HWV68_17245	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_17250	COG3433	isochorismatase activity
HWV68_17250	COG1535	isochorismatase
HWV68_17255	COG1021	2,3-dihydroxybenzoate-AMP ligase
HWV68_17260	COG1169	isochorismate synthase
HWV68_17265	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_17270	COG2819	hydrolase of the alpha beta superfamily
HWV68_17275	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HWV68_17280	COG1268	BioY protein
HWV68_17285	COG2056	Na+-H+ antiporter family
HWV68_17290	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HWV68_17295	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
HWV68_17300	COG3584	3D domain protein
HWV68_17315	COG1252	NADH dehydrogenase
HWV68_17320	COG0492	ferredoxin-NADP+ reductase activity
HWV68_17330	COG0516	GMP reductase activity
HWV68_17335	COG2808	Putative FMN-binding domain
HWV68_17340	COG0456	acetyltransferase
HWV68_17345	COG0316	Belongs to the HesB IscA family
HWV68_17350	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HWV68_17355	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HWV68_17360	COG4844	belongs to the
HWV68_17365	COG1252	NADH dehydrogenase
HWV68_17370	COG4837	Protein of unknown function (DUF1462)
HWV68_17375	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HWV68_17380	COG4946	Tricorn protease homolog
HWV68_17380	COG1506	peptidase
HWV68_17380	COG0823	Involved in the tonB-independent uptake of proteins
HWV68_17385	COG0083	homoserine kinase activity
HWV68_17390	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HWV68_17395	COG0460	homoserine dehydrogenase
HWV68_17400	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HWV68_17405	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HWV68_17410	COG0647	UMP catabolic process
HWV68_17415	COG2445	Protein of unknown function DUF86
HWV68_17420	COG4470	Protein conserved in bacteria
HWV68_17430	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HWV68_17435	COG0739	heme binding
HWV68_17445	COG3377	Domain of unknown function (DUF1805)
HWV68_17450	COG0737	Belongs to the 5'-nucleotidase family
HWV68_17455	COG0730	response to heat
HWV68_17460	COG1801	Protein of unknown function DUF72
HWV68_17470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HWV68_17475	COG2508	Transcriptional regulator
HWV68_17480	COG2233	PERMEase
HWV68_17485	COG2233	PERMEase
HWV68_17490	COG3195	allantoin biosynthetic process
HWV68_17490	COG3648	Uricase
HWV68_17495	COG2351	hydroxyisourate hydrolase activity
HWV68_17505	COG2080	2 iron, 2 sulfur cluster binding
HWV68_17510	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HWV68_17515	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HWV68_17520	COG2068	MobA-Related Protein
HWV68_17525	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HWV68_17530	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
HWV68_17535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HWV68_17545	COG2356	endonuclease I
HWV68_17550	COG3842	ATPase activity
HWV68_17555	COG2188	Transcriptional regulator
HWV68_17560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWV68_17565	COG0395	ABC-type sugar transport system, permease component
HWV68_17570	COG1175	transmembrane transport
HWV68_17575	COG1653	transport
HWV68_17580	COG2222	sugar isomerase
HWV68_17585	COG0322	excinuclease ABC activity
HWV68_17590	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HWV68_17605	COG0346	lactoylglutathione lyase activity
HWV68_17610	COG0640	Transcriptional regulator
HWV68_17615	COG0719	Fe-S assembly protein
HWV68_17620	COG0822	iron-sulfur transferase activity
HWV68_17625	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HWV68_17630	COG0719	Fe-S assembly protein
HWV68_17635	COG0396	ATPase activity
HWV68_17645	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HWV68_17650	COG1464	Belongs to the NlpA lipoprotein family
HWV68_17655	COG2011	ABC-type metal ion transport system permease component
HWV68_17660	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HWV68_17670	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HWV68_17675	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
HWV68_17685	COG0509	glycine decarboxylation via glycine cleavage system
HWV68_17690	COG1393	Belongs to the ArsC family
HWV68_17695	COG1960	acyl-CoA dehydrogenase activity
HWV68_17700	COG0183	Belongs to the thiolase family
HWV68_17705	COG1250	3-hydroxyacyl-CoA dehydrogenase
HWV68_17705	COG1024	Enoyl-CoA hydratase
HWV68_17715	COG0506	proline dehydrogenase activity
HWV68_17725	COG5577	PFAM Coat F domain
HWV68_17730	COG1846	Transcriptional regulator
HWV68_17735	COG0477	Major facilitator Superfamily
HWV68_17740	COG1942	4-Oxalocrotonate Tautomerase
HWV68_17750	COG0583	DNA-binding transcription factor activity
HWV68_17760	COG1120	ATPase activity
HWV68_17775	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_17780	COG0783	Belongs to the Dps family
HWV68_17785	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWV68_17790	COG0745	RESPONSE REGULATOR receiver
HWV68_17795	COG2770	Histidine kinase
HWV68_17795	COG2205	protein histidine kinase activity
HWV68_17805	COG1309	transcriptional regulator
HWV68_17810	COG0114	fumarate hydratase activity
HWV68_17820	COG0697	spore germination
HWV68_17825	COG0814	amino acid
HWV68_17835	COG2197	response regulator
HWV68_17840	COG4585	Histidine kinase
HWV68_17845	COG4758	membrane
HWV68_17850	COG3595	metallopeptidase activity
HWV68_17855	COG1842	Phage shock protein A
HWV68_17860	COG4758	membrane
HWV68_17865	COG2814	Major facilitator Superfamily
HWV68_17870	COG2096	Adenosyltransferase
HWV68_17875	COG1120	ATPase activity
HWV68_17880	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWV68_17885	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HWV68_17890	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_17895	COG3386	PFAM SMP-30 Gluconolaconase
HWV68_17900	COG2205	protein histidine kinase activity
HWV68_17905	COG0745	RESPONSE REGULATOR receiver
HWV68_17915	COG1191	sigma factor activity
HWV68_17925	COG2140	Oxalate decarboxylase
HWV68_17935	COG0577	efflux transmembrane transporter activity
HWV68_17940	COG1136	(ABC) transporter
HWV68_17945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HWV68_17950	COG1120	ATPase activity
HWV68_17955	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWV68_17960	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HWV68_17965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HWV68_17970	COG0531	amino acid
HWV68_17980	COG1988	membrane-bound metal-dependent
HWV68_17985	COG1368	sulfuric ester hydrolase activity
HWV68_17990	COG1910	domain protein
HWV68_17995	COG0725	ABC transporter, periplasmic molybdate-binding protein
HWV68_18000	COG4149	molybdate abc transporter
HWV68_18005	COG0656	L-ascorbic acid biosynthetic process
HWV68_18015	COG0025	NhaP-type Na H and K H
HWV68_18020	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HWV68_18025	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
HWV68_18030	COG3973	AAA domain
HWV68_18035	COG2860	membrane
HWV68_18040	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HWV68_18045	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HWV68_18050	COG2217	Heavy metal translocating P-type atpase
HWV68_18055	COG2217	Heavy metal translocating P-type atpase
HWV68_18060	COG2608	mercury ion transmembrane transporter activity
HWV68_18065	COG1937	Protein conserved in bacteria
HWV68_18070	COG0673	inositol 2-dehydrogenase activity
HWV68_18075	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HWV68_18080	COG1289	transmembrane transporter activity
HWV68_18090	COG2076	Multidrug Resistance protein
HWV68_18095	COG1309	transcriptional regulator
HWV68_18100	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_18110	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HWV68_18115	COG0557	exoribonuclease II activity
HWV68_18120	COG1647	Serine aminopeptidase, S33
HWV68_18125	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HWV68_18130	COG0596	Alpha beta hydrolase
HWV68_18135	COG1476	TRANSCRIPTIONal
HWV68_18140	COG1396	sequence-specific DNA binding
HWV68_18145	COG1396	sequence-specific DNA binding
HWV68_18150	COG1733	regulation of RNA biosynthetic process
HWV68_18155	COG0840	transmembrane signaling receptor activity
HWV68_18160	COG1174	glycine betaine transport
HWV68_18165	COG1732	Glycine betaine
HWV68_18170	COG1174	glycine betaine transport
HWV68_18175	COG1125	glycine betaine transport
HWV68_18175	COG0517	IMP dehydrogenase activity
HWV68_18180	COG1510	regulation of RNA biosynthetic process
HWV68_18200	COG5658	integral membrane protein
HWV68_18205	COG0640	Transcriptional regulator
HWV68_18210	COG1174	glycine betaine transport
HWV68_18215	COG1732	Glycine betaine
HWV68_18220	COG1174	glycine betaine transport
HWV68_18225	COG0517	IMP dehydrogenase activity
HWV68_18225	COG1125	glycine betaine transport
HWV68_18230	COG1510	regulation of RNA biosynthetic process
HWV68_18235	COG2095	MarC family integral membrane protein
HWV68_18245	COG3064	Membrane
HWV68_18250	COG4640	response to antibiotic
HWV68_18255	COG0456	acetyltransferase
HWV68_18260	COG0148	phosphopyruvate hydratase activity
HWV68_18265	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
HWV68_18270	COG0149	triose-phosphate isomerase activity
HWV68_18275	COG0126	phosphoglycerate kinase activity
HWV68_18280	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HWV68_18285	COG2390	Transcriptional regulator
HWV68_18290	COG2814	Major facilitator Superfamily
HWV68_18295	COG1609	Transcriptional regulator
HWV68_18300	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWV68_18305	COG0583	DNA-binding transcription factor activity
HWV68_18310	COG0697	spore germination
HWV68_18315	COG1113	amino acid transport
HWV68_18320	COG3858	chitin binding
HWV68_18325	COG1556	Lactate utilization protein
HWV68_18330	COG1139	Iron-sulfur cluster binding protein
HWV68_18335	COG0247	lactate metabolic process
HWV68_18340	COG2197	response regulator
HWV68_18345	COG4585	Histidine kinase
HWV68_18350	COG0842	Transport permease protein
HWV68_18355	COG1131	(ABC) transporter
HWV68_18360	COG0596	Alpha beta hydrolase
HWV68_18365	COG2208	phosphoserine phosphatase activity
HWV68_18370	COG3867	Arabinogalactan endo-beta-1,4-galactanase
HWV68_18375	COG1874	Beta-galactosidase
HWV68_18380	COG3833	ABC-type maltose transport systems, permease component
HWV68_18385	COG1175	transmembrane transport
HWV68_18390	COG2182	Extracellular solute-binding protein
HWV68_18395	COG1609	Transcriptional regulator
HWV68_18400	COG2186	Transcriptional regulator
HWV68_18405	COG1620	l-lactate permease
HWV68_18410	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HWV68_18420	COG5039	Polysaccharide pyruvyl transferase
HWV68_18425	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HWV68_18430	COG0110	maltose O-acetyltransferase activity
HWV68_18435	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HWV68_18440	COG2244	polysaccharide biosynthetic process
HWV68_18445	COG1216	Glycosyl transferase, family 2
HWV68_18450	COG5039	Polysaccharide pyruvyl transferase
HWV68_18455	COG1216	Glycosyl transferase, family 2
HWV68_18465	COG0438	transferase activity, transferring glycosyl groups
HWV68_18470	COG1215	transferase activity, transferring glycosyl groups
HWV68_18475	COG0438	transferase activity, transferring glycosyl groups
HWV68_18480	COG1086	Polysaccharide biosynthesis protein
HWV68_18485	COG0489	protein tyrosine kinase activity
HWV68_18490	COG3944	biosynthesis protein
HWV68_18495	COG1396	sequence-specific DNA binding
HWV68_18500	COG2272	Belongs to the type-B carboxylesterase lipase family
HWV68_18510	COG3479	Phenolic acid decarboxylase
HWV68_18520	COG1794	racemase activity, acting on amino acids and derivatives
HWV68_18525	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HWV68_18530	COG1621	beta-fructofuranosidase activity
HWV68_18535	COG1621	beta-fructofuranosidase activity
HWV68_18540	COG0531	amino acid
HWV68_18545	COG1309	transcriptional regulator
HWV68_18550	COG2076	Multidrug Resistance protein
HWV68_18555	COG2076	Multidrug Resistance protein
HWV68_18565	COG0277	FAD linked oxidase domain protein
HWV68_18570	COG3621	Patatin-like phospholipase
HWV68_18580	COG0740	serine-type endopeptidase activity
HWV68_18585	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HWV68_18590	COG0366	Alpha amylase catalytic
HWV68_18595	COG1554	hydrolase, family 65, central catalytic
HWV68_18600	COG5521	maltodextrose utilization protein MalA
HWV68_18605	COG3833	ABC-type maltose transport systems, permease component
HWV68_18610	COG1175	transmembrane transport
HWV68_18615	COG2182	Extracellular solute-binding protein
HWV68_18620	COG0366	Alpha amylase catalytic
HWV68_18625	COG1609	Transcriptional regulator
HWV68_18630	COG1611	Belongs to the LOG family
HWV68_18635	COG1694	Mazg nucleotide pyrophosphohydrolase
HWV68_18640	COG0659	secondary active sulfate transmembrane transporter activity
HWV68_18645	COG0288	reversible hydration of carbon dioxide
HWV68_18650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HWV68_18655	COG0577	efflux transmembrane transporter activity
HWV68_18660	COG1136	(ABC) transporter
HWV68_18665	COG5002	protein histidine kinase activity
HWV68_18670	COG0745	RESPONSE REGULATOR receiver
HWV68_18680	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HWV68_18685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWV68_18690	COG1481	regulation of sporulation
HWV68_18695	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HWV68_18700	COG1660	Displays ATPase and GTPase activities
HWV68_18705	COG1051	belongs to the nudix hydrolase family
HWV68_18710	COG0492	ferredoxin-NADP+ reductase activity
HWV68_18715	COG0791	NLP P60 protein
HWV68_18715	COG3883	PFAM NLP P60 protein
HWV68_18720	COG0457	Tetratricopeptide repeat
HWV68_18725	COG1132	(ABC) transporter
HWV68_18745	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HWV68_18745	COG0140	phosphoribosyl-ATP diphosphatase activity
HWV68_18750	COG0107	imidazoleglycerol-phosphate synthase activity
HWV68_18755	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HWV68_18760	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HWV68_18765	COG0131	Imidazoleglycerol-phosphate dehydratase
HWV68_18770	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HWV68_18775	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HWV68_18780	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HWV68_18785	COG4990	cell redox homeostasis
HWV68_18790	COG5297	Belongs to the glycosyl hydrolase family 6
HWV68_18795	COG0110	maltose O-acetyltransferase activity
HWV68_18800	COG0546	phosphoglycolate phosphatase activity
HWV68_18805	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HWV68_18810	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HWV68_18815	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
HWV68_18820	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HWV68_18825	COG0363	glucosamine-6-phosphate deaminase activity
HWV68_18830	COG2188	Transcriptional regulator
HWV68_18835	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HWV68_18840	COG1846	Transcriptional regulator
HWV68_18845	COG2124	cytochrome p450
HWV68_18855	COG1846	Transcriptional regulator
HWV68_18860	COG2814	Major facilitator Superfamily
HWV68_18865	COG1950	PFAM Membrane protein of
HWV68_18870	COG1983	PspC domain protein
HWV68_18875	COG3595	metallopeptidase activity
HWV68_18895	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HWV68_18900	COG0556	nucleotide-excision repair
HWV68_18905	COG4897	Protein conserved in bacteria
HWV68_18910	COG0574	Belongs to the PEP-utilizing enzyme family
HWV68_18910	COG3848	Pyruvate phosphate dikinase
HWV68_18915	COG1309	transcriptional regulator
HWV68_18920	COG2814	Major facilitator Superfamily
HWV68_18925	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWV68_18935	COG0793	Belongs to the peptidase S41A family
HWV68_18935	COG3409	Peptidoglycan-binding domain 1 protein
HWV68_18940	COG2177	Part of the ABC transporter FtsEX involved in
HWV68_18945	COG2884	Cell division ATP-binding protein ftsE
HWV68_18950	COG2010	Cytochrome c
HWV68_18955	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HWV68_18965	COG0653	protein targeting
HWV68_18970	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HWV68_18985	COG1516	flagellar protein fliS
HWV68_18990	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HWV68_18995	COG1334	flagellar protein FlaG
HWV68_19000	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HWV68_19005	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HWV68_19010	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
HWV68_19020	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HWV68_19025	COG1256	bacterial-type flagellum assembly
HWV68_19025	COG4786	Flagellar basal body rod
HWV68_19030	COG3418	PFAM FlgN family protein
HWV68_19035	COG2747	anti-sigma28 factor FlgM
HWV68_19045	COG1040	competence protein
HWV68_19055	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
HWV68_19060	COG1307	EDD domain protein, DegV family
HWV68_19065	COG2197	response regulator
HWV68_19070	COG4585	Histidine kinase
HWV68_19075	COG1739	Uncharacterized protein family UPF0029
HWV68_19080	COG1316	TRANSCRIPTIONal
HWV68_19085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HWV68_19090	COG0438	transferase activity, transferring glycosyl groups
HWV68_19095	COG1215	transferase activity, transferring glycosyl groups
HWV68_19100	COG3206	protein involved in exopolysaccharide biosynthesis
HWV68_19105	COG3307	-O-antigen
HWV68_19110	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HWV68_19115	COG0438	transferase activity, transferring glycosyl groups
HWV68_19115	COG0297	glycogen (starch) synthase activity
HWV68_19120	COG2244	polysaccharide biosynthetic process
HWV68_19130	COG0860	N-Acetylmuramoyl-L-alanine amidase
HWV68_19130	COG2247	cell wall binding repeat
HWV68_19135	COG2247	cell wall binding repeat
HWV68_19135	COG2385	sporulation resulting in formation of a cellular spore
HWV68_19145	COG1316	TRANSCRIPTIONal
HWV68_19150	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HWV68_19155	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HWV68_19165	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HWV68_19165	COG1215	transferase activity, transferring glycosyl groups
HWV68_19170	COG0463	Glycosyl transferase, family 2
HWV68_19180	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HWV68_19190	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HWV68_19195	COG1134	teichoic acid transport
HWV68_19200	COG1682	transport, permease protein
HWV68_19205	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HWV68_19210	COG0438	transferase activity, transferring glycosyl groups
HWV68_19215	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HWV68_19220	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
HWV68_19225	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HWV68_19235	COG4193	domain, Protein
HWV68_19240	COG1482	cell wall glycoprotein biosynthetic process
HWV68_19245	COG0697	spore germination
HWV68_19250	COG0814	amino acid
HWV68_19260	COG2814	Major facilitator Superfamily
HWV68_19265	COG1316	TRANSCRIPTIONal
HWV68_19270	COG0561	phosphatase activity
HWV68_19275	COG0791	NLP P60 protein
HWV68_19285	COG2843	Capsule synthesis protein
HWV68_19295	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HWV68_19300	COG1609	Transcriptional regulator
HWV68_19305	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWV68_19310	COG1869	D-ribose catabolic process
HWV68_19315	COG1129	ABC transporter
HWV68_19320	COG1172	Belongs to the binding-protein-dependent transport system permease family
HWV68_19325	COG1879	ABC-type sugar transport system periplasmic component
HWV68_19330	COG3103	Sh3 type 3 domain protein
HWV68_19340	COG2249	NAD(P)H dehydrogenase (quinone) activity
HWV68_19345	COG3527	Alpha-acetolactate decarboxylase
HWV68_19350	COG0028	Belongs to the TPP enzyme family
HWV68_19355	COG0583	DNA-binding transcription factor activity
HWV68_19360	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HWV68_19375	COG5337	Spore coat protein CotH
HWV68_19385	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HWV68_19395	COG0405	Gamma-glutamyltransferase
HWV68_19400	COG1522	sequence-specific DNA binding
HWV68_19405	COG2059	Chromate
HWV68_19410	COG2059	Chromate
HWV68_19420	COG0655	NAD(P)H dehydrogenase (quinone) activity
HWV68_19425	COG0583	DNA-binding transcription factor activity
HWV68_19430	COG1515	deoxyribonuclease V activity
HWV68_19435	COG2849	repeat protein
HWV68_19440	COG5444	nuclease activity
HWV68_19460	COG3878	Protein conserved in bacteria
HWV68_19465	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HWV68_19470	COG4464	protein tyrosine phosphatase activity
HWV68_19475	COG0489	protein tyrosine kinase activity
HWV68_19480	COG3944	biosynthesis protein
HWV68_19490	COG4715	Zinc finger, swim domain protein
HWV68_19495	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HWV68_19500	COG0561	phosphatase activity
HWV68_19505	COG1349	DNA-binding transcription factor activity
HWV68_19510	COG0629	single-stranded DNA binding
HWV68_19535	COG2972	Histidine kinase
HWV68_19535	COG0745	RESPONSE REGULATOR receiver
HWV68_19540	COG1970	mechanosensitive ion channel activity
HWV68_19545	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HWV68_19550	COG0457	Tetratricopeptide repeat
HWV68_19555	COG4786	Flagellar basal body rod
HWV68_19560	COG4786	Flagellar basal body rod
HWV68_19565	COG1077	Cell shape determining protein MreB Mrl
HWV68_19570	COG1609	Transcriptional regulator
HWV68_19580	COG1846	Transcriptional regulator
HWV68_19585	COG2814	Major facilitator Superfamily
HWV68_19590	COG3420	alginic acid biosynthetic process
HWV68_19595	COG1953	Uracil, thiamine, allantoin
HWV68_19600	COG0477	Major facilitator Superfamily
HWV68_19605	COG1335	isochorismatase
HWV68_19615	COG0004	ammonium transporteR
HWV68_19620	COG0347	Belongs to the P(II) protein family
HWV68_19625	COG0671	phosphoesterase, PA-phosphatase related
HWV68_19635	COG0739	heme binding
HWV68_19640	COG1247	-acetyltransferase
HWV68_19660	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HWV68_19665	COG0789	Transcriptional regulator
HWV68_19675	COG2910	NAD(P)H-binding
HWV68_19680	COG1959	2 iron, 2 sulfur cluster binding
HWV68_19685	COG0804	urea catabolic process
HWV68_19690	COG0832	Belongs to the urease beta subunit family
HWV68_19695	COG0831	urea catabolic process
HWV68_19715	COG3237	CsbD-like
HWV68_19720	COG1994	Peptidase M50
HWV68_19725	COG0457	Tetratricopeptide repeat
HWV68_19730	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HWV68_19735	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
HWV68_19745	COG2304	oxidoreductase activity
HWV68_19755	COG2304	oxidoreductase activity
HWV68_19760	COG2385	sporulation resulting in formation of a cellular spore
HWV68_19765	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HWV68_19775	COG4836	Membrane
HWV68_19785	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HWV68_19790	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HWV68_19795	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HWV68_19800	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HWV68_19805	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HWV68_19810	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HWV68_19820	COG0356	it plays a direct role in the translocation of protons across the membrane
HWV68_19830	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
HWV68_19835	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HWV68_19840	COG4475	Protein of unknown function (DUF436)
HWV68_19845	COG0698	ribose 5-phosphate isomerase
HWV68_19850	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HWV68_19855	COG1971	Probably functions as a manganese efflux pump
HWV68_19860	COG0009	L-threonylcarbamoyladenylate synthase
HWV68_19865	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HWV68_19885	COG2890	protein-(glutamine-N5) methyltransferase activity
HWV68_19890	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HWV68_19895	COG0346	lactoylglutathione lyase activity
HWV68_19900	COG0789	Transcriptional regulator
HWV68_19905	COG0679	Auxin Efflux Carrier
HWV68_19910	COG0281	malic enzyme
HWV68_19915	COG1435	thymidine kinase activity
HWV68_19925	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HWV68_19935	COG1494	fructose-1,6-bisphosphatase
HWV68_19940	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HWV68_19945	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HWV68_19950	COG0191	fructose-bisphosphate aldolase activity
HWV68_19955	COG2204	response regulator
HWV68_19960	COG4821	SIS domain
HWV68_19965	COG0504	CTP synthase activity
HWV68_19970	COG3343	RNA polymerase activity
HWV68_19975	COG1960	acyl-CoA dehydrogenase activity
HWV68_19980	COG0247	lactate metabolic process
HWV68_19980	COG2181	nitrate reductase activity
HWV68_19985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HWV68_19990	COG4294	response to UV
HWV68_20000	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HWV68_20005	COG1132	(ABC) transporter
HWV68_20010	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HWV68_20015	COG2181	nitrate reductase activity
HWV68_20020	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HWV68_20025	COG1140	nitrate reductase beta subunit
HWV68_20030	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HWV68_20035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HWV68_20045	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HWV68_20050	COG2223	nitrite transmembrane transporter activity
HWV68_20055	COG0018	arginyl-trna synthetase
HWV68_20060	COG4506	Protein conserved in bacteria
HWV68_20075	COG0535	radical SAM domain protein
HWV68_20085	COG1131	(ABC) transporter
HWV68_20090	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HWV68_20095	COG0612	Peptidase, M16
HWV68_20100	COG0612	Peptidase, M16
HWV68_20110	COG3391	amine dehydrogenase activity
HWV68_20115	COG3391	amine dehydrogenase activity
HWV68_20120	COG0457	Tetratricopeptide repeat
HWV68_20130	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HWV68_20135	COG0010	Belongs to the arginase family
HWV68_20140	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
HWV68_20145	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HWV68_20155	COG1994	Peptidase M50
HWV68_20160	COG1942	4-Oxalocrotonate Tautomerase
HWV68_20165	COG1846	Transcriptional regulator
HWV68_20170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HWV68_20175	COG0477	Major facilitator Superfamily
HWV68_20180	COG1959	2 iron, 2 sulfur cluster binding
HWV68_20185	COG3465	dGTPase activity
HWV68_20190	COG1078	dGTPase activity
HWV68_20195	COG4844	belongs to the
HWV68_20205	COG0697	spore germination
HWV68_20210	COG0095	Lipoate-protein ligase
HWV68_20215	COG0583	DNA-binding transcription factor activity
HWV68_20220	COG0280	phosphate acetyltransferase
HWV68_20230	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_20235	COG0436	Aminotransferase
HWV68_20240	COG2814	Major facilitator Superfamily
HWV68_20245	COG0151	Belongs to the GarS family
HWV68_20250	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_20255	COG1917	Cupin 2, conserved barrel domain protein
HWV68_20260	COG0077	Prephenate dehydratase
HWV68_20265	COG2814	Major facilitator Superfamily
HWV68_20270	COG0833	amino acid
HWV68_20275	COG4187	Peptidase family M20/M25/M40
HWV68_20280	COG1012	belongs to the aldehyde dehydrogenase family
HWV68_20285	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HWV68_20295	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
HWV68_20300	COG1091	dTDP-4-dehydrorhamnose reductase activity
HWV68_20305	COG1088	dTDP-glucose 4,6-dehydratase activity
HWV68_20310	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HWV68_20315	COG3980	spore coat polysaccharide biosynthesis protein
HWV68_20320	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
HWV68_20325	COG2089	acid synthase
HWV68_20330	COG0456	acetyltransferase
HWV68_20335	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HWV68_20340	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
HWV68_20345	COG0463	Glycosyl transferase, family 2
HWV68_20355	COG2363	Small membrane protein
HWV68_20360	COG2233	PERMEase
HWV68_20370	COG1012	belongs to the aldehyde dehydrogenase family
HWV68_20375	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HWV68_20380	COG1216	Glycosyl transferase, family 2
HWV68_20395	COG1695	Transcriptional regulator
HWV68_20400	COG0351	phosphomethylpyrimidine kinase
HWV68_20410	COG1621	beta-fructofuranosidase activity
HWV68_20415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWV68_20415	COG1263	PTS System
HWV68_20420	COG2116	formate transmembrane transporter activity
HWV68_20425	COG3711	transcriptional antiterminator
HWV68_20435	COG1404	Belongs to the peptidase S8 family
HWV68_20440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWV68_20445	COG0778	Nitroreductase
HWV68_20450	COG0772	Belongs to the SEDS family
HWV68_20460	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HWV68_20465	COG1845	cytochrome c oxidase, subunit III
HWV68_20470	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HWV68_20475	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HWV68_20480	COG2261	transglycosylase associated protein
HWV68_20485	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
HWV68_20490	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
HWV68_20495	COG2246	polysaccharide biosynthetic process
HWV68_20500	COG1309	transcriptional regulator
HWV68_20510	COG3162	membrane
HWV68_20515	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HWV68_20520	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HWV68_20525	COG2837	iron assimilation
HWV68_20530	COG2822	iron ion transport
HWV68_20535	COG0672	)-iron permease
HWV68_20540	COG0352	thiamine-phosphate diphosphorylase activity
HWV68_20545	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
HWV68_20550	COG0583	DNA-binding transcription factor activity
HWV68_20555	COG1380	Effector of murein hydrolase LrgA
HWV68_20560	COG1346	cytolysis
HWV68_20565	COG2814	Major facilitator Superfamily
HWV68_20570	COG4895	conserved protein (DUF2196)
HWV68_20575	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
HWV68_20580	COG0346	lactoylglutathione lyase activity
HWV68_20590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HWV68_20595	COG1404	Belongs to the peptidase S8 family
HWV68_20600	COG1263	PTS System
HWV68_20600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWV68_20605	COG3711	transcriptional antiterminator
HWV68_20610	COG1442	glycosyl transferase family 8
HWV68_20615	COG5522	Integral membrane protein (intg_mem_TP0381)
HWV68_20620	COG1846	Transcriptional regulator
HWV68_20625	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HWV68_20630	COG2234	aminopeptidase activity
HWV68_20635	COG2357	RelA SpoT domain protein
HWV68_20640	COG1575	Belongs to the MenA family. Type 1 subfamily
HWV68_20655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HWV68_20660	COG1696	Membrane protein involved in D-alanine export
HWV68_20665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HWV68_20670	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
HWV68_20675	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HWV68_20680	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HWV68_20685	COG1486	melibiose metabolic process
HWV68_20690	COG1447	Phosphotransferase system cellobiose-specific component IIA
HWV68_20695	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HWV68_20700	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HWV68_20705	COG3711	transcriptional antiterminator
HWV68_20705	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HWV68_20715	COG2094	Belongs to the DNA glycosylase MPG family
HWV68_20720	COG0753	catalase activity
HWV68_20725	COG2814	Major facilitator Superfamily
HWV68_20730	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
HWV68_20735	COG1131	(ABC) transporter
HWV68_20755	COG1595	DNA-templated transcription, initiation
HWV68_20760	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HWV68_20765	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HWV68_20770	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HWV68_20775	COG4988	ABC transporter
HWV68_20780	COG1294	oxidase, subunit
HWV68_20785	COG1271	oxidase subunit
HWV68_20790	COG3493	citrate carrier protein
HWV68_20795	COG0501	Belongs to the peptidase M48B family
HWV68_20805	COG0726	polysaccharide deacetylase
HWV68_20810	COG3842	ATPase activity
HWV68_20815	COG2508	Transcriptional regulator
HWV68_20820	COG1012	belongs to the aldehyde dehydrogenase family
HWV68_20825	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
HWV68_20835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HWV68_20840	COG1881	PFAM PEBP family protein
HWV68_20845	COG0583	DNA-binding transcription factor activity
HWV68_20855	COG4585	Histidine kinase
HWV68_20860	COG2197	response regulator
HWV68_20865	COG2195	Cleaves the N-terminal amino acid of tripeptides
HWV68_20875	COG4894	glucomannan catabolic process
HWV68_20880	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HWV68_20885	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HWV68_20890	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_20895	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HWV68_20900	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HWV68_20905	COG2610	gluconate transmembrane transporter activity
HWV68_20910	COG0500	methyltransferase
HWV68_20915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HWV68_20930	COG0693	protein deglycase activity
HWV68_20930	COG0753	catalase activity
HWV68_20935	COG2851	Citrate transporter
HWV68_20940	COG2273	Hydrolase Family 16
HWV68_20945	COG3711	transcriptional antiterminator
HWV68_20955	COG2270	Major facilitator Superfamily
HWV68_20960	COG0513	Belongs to the DEAD box helicase family
HWV68_20965	COG3401	FG-GAP repeat protein
HWV68_20965	COG2755	lipolytic protein G-D-S-L family
HWV68_21020	COG3209	COG3209 Rhs family protein
HWV68_21025	COG0697	spore germination
HWV68_21030	COG0589	response to stress
HWV68_21035	COG2723	6-phospho-beta-galactosidase activity
HWV68_21040	COG2190	(PTS) system
HWV68_21040	COG1263	PTS System
HWV68_21040	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HWV68_21055	COG5444	nuclease activity
HWV68_21070	COG3507	Belongs to the glycosyl hydrolase 43 family
HWV68_21085	COG2986	histidine ammonia-lyase
HWV68_21090	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HWV68_21095	COG1228	amidohydrolase
HWV68_21100	COG0010	Belongs to the arginase family
HWV68_21105	COG0833	amino acid
HWV68_21110	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HWV68_21115	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HWV68_21120	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
HWV68_21125	COG2390	Transcriptional regulator
HWV68_21135	COG3192	ethanolamine utilization protein
HWV68_21140	COG2079	MmgE PrpD family protein
HWV68_21145	COG1473	amidohydrolase
HWV68_21150	COG1126	abc transporter atp-binding protein
HWV68_21155	COG0765	amino acid transport
HWV68_21160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HWV68_21165	COG0456	acetyltransferase
HWV68_21170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HWV68_21180	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
HWV68_21185	COG0561	phosphatase activity
HWV68_21215	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HWV68_21220	COG5294	Protein conserved in bacteria
HWV68_21225	COG0577	efflux transmembrane transporter activity
HWV68_21230	COG1136	(ABC) transporter
HWV68_21235	COG2205	protein histidine kinase activity
HWV68_21240	COG0745	RESPONSE REGULATOR receiver
HWV68_21245	COG0191	fructose-bisphosphate aldolase activity
HWV68_21250	COG1082	Xylose isomerase domain protein TIM barrel
HWV68_21255	COG1082	Xylose isomerase domain protein TIM barrel
HWV68_21260	COG0673	inositol 2-dehydrogenase activity
HWV68_21265	COG2814	Major facilitator Superfamily
HWV68_21270	COG1082	Xylose isomerase domain protein TIM barrel
HWV68_21275	COG3962	Belongs to the TPP enzyme family
HWV68_21280	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HWV68_21285	COG3718	enzyme involved in inositol metabolism
HWV68_21290	COG1012	belongs to the aldehyde dehydrogenase family
HWV68_21295	COG1349	DNA-binding transcription factor activity
HWV68_21300	COG0667	Aldo Keto reductase
HWV68_21315	COG2814	Major facilitator Superfamily
HWV68_21320	COG0326	Molecular chaperone. Has ATPase activity
HWV68_21330	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_21335	COG1309	transcriptional regulator
HWV68_21340	COG1012	belongs to the aldehyde dehydrogenase family
HWV68_21345	COG0456	acetyltransferase
HWV68_21350	COG2850	peptidyl-arginine hydroxylation
HWV68_21355	COG2226	methyltransferase
HWV68_21370	COG0367	asparagine synthase
HWV68_21375	COG2814	Major facilitator Superfamily
HWV68_21380	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HWV68_21390	COG1714	RDD family
HWV68_21395	COG2311	Membrane
HWV68_21400	COG1917	Cupin 2, conserved barrel domain protein
HWV68_21405	COG1309	transcriptional regulator
HWV68_21410	COG1028	Short-chain dehydrogenase reductase Sdr
HWV68_21415	COG1846	Transcriptional regulator
HWV68_21420	COG1380	Effector of murein hydrolase LrgA
HWV68_21425	COG1346	cytolysis
HWV68_21430	COG5039	Polysaccharide pyruvyl transferase
HWV68_21435	COG1929	Belongs to the glycerate kinase type-1 family
HWV68_21440	COG1802	Transcriptional regulator
HWV68_21445	COG1070	Carbohydrate kinase
HWV68_21450	COG2610	gluconate transmembrane transporter activity
HWV68_21455	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HWV68_21460	COG0450	alkyl hydroperoxide reductase
HWV68_21465	COG3634	alkyl hydroperoxide reductase activity
HWV68_21470	COG2723	6-phospho-beta-galactosidase activity
HWV68_21480	COG2188	Transcriptional regulator
HWV68_21495	COG1131	(ABC) transporter
HWV68_21500	COG1994	Peptidase M50
HWV68_21505	COG0535	radical SAM domain protein
HWV68_21515	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
HWV68_21520	COG5293	efflux transmembrane transporter activity
HWV68_21530	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HWV68_21535	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HWV68_21550	COG1063	alcohol dehydrogenase
HWV68_21570	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HWV68_21575	COG0456	acetyltransferase
HWV68_21580	COG0457	Tetratricopeptide repeat
HWV68_21590	COG0010	Belongs to the arginase family
HWV68_21595	COG0833	amino acid
HWV68_21600	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HWV68_21605	COG3829	transcription factor binding
HWV68_21620	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HWV68_21625	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HWV68_21630	COG4853	Protein conserved in bacteria
HWV68_21635	COG4863	YycH protein
HWV68_21640	COG5002	protein histidine kinase activity
HWV68_21645	COG0745	RESPONSE REGULATOR receiver
HWV68_21675	COG0346	lactoylglutathione lyase activity
HWV68_21680	COG0305	Participates in initiation and elongation during chromosome replication
HWV68_21695	COG3093	addiction module antidote protein HigA
HWV68_21700	COG2807	transmembrane transport
HWV68_21705	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
HWV68_21710	COG0359	binds to the 23S rRNA
HWV68_21715	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
HWV68_21720	COG4241	membrane
HWV68_21730	COG5577	PFAM Coat F domain
HWV68_21735	COG1733	regulation of RNA biosynthetic process
HWV68_21740	COG1227	inorganic diphosphatase activity
HWV68_21755	COG2271	Major facilitator Superfamily
HWV68_21790	COG1131	(ABC) transporter
HWV68_21805	COG4319	ketosteroid isomerase
HWV68_21810	COG1357	PFAM Pentapeptide repeats (8 copies)
HWV68_21815	COG2814	Major facilitator Superfamily
HWV68_21820	COG0583	DNA-binding transcription factor activity
HWV68_21825	COG2153	protein acetylation
HWV68_21835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HWV68_21840	COG1846	Transcriptional regulator
HWV68_21845	COG2153	protein acetylation
HWV68_21850	COG2364	Membrane
HWV68_21855	COG0456	acetyltransferase
HWV68_21860	COG2315	Protein conserved in bacteria
HWV68_21865	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HWV68_21875	COG2814	Major facilitator Superfamily
HWV68_21885	COG1331	Highly conserved protein containing a thioredoxin domain
HWV68_21890	COG0789	Transcriptional regulator
HWV68_21895	COG0697	spore germination
HWV68_21900	COG1331	Highly conserved protein containing a thioredoxin domain
HWV68_21905	COG1266	CAAX protease self-immunity
HWV68_21910	COG2814	Major facilitator Superfamily
HWV68_21910	COG0477	Major facilitator Superfamily
HWV68_21915	COG0110	maltose O-acetyltransferase activity
HWV68_21920	COG0346	lactoylglutathione lyase activity
HWV68_21925	COG1609	Transcriptional regulator
HWV68_21930	COG0708	Exodeoxyribonuclease III
HWV68_21935	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HWV68_21940	COG0629	single-stranded DNA binding
HWV68_21945	COG0360	Binds together with S18 to 16S ribosomal RNA
HWV68_21950	COG0012	GTP binding
HWV68_21955	COG0243	molybdopterin cofactor binding
HWV68_21960	COG4481	Protein conserved in bacteria
HWV68_21965	COG3949	Membrane
HWV68_21975	COG1475	DNA binding
HWV68_21980	COG1192	Involved in chromosome partitioning
HWV68_21990	COG1475	DNA binding
HWV68_21995	COG0357	Ribosomal RNA small subunit methyltransferase G
HWV68_22000	COG0445	tRNA wobble uridine modification
HWV68_22005	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HWV68_22010	COG1847	R3H domain protein
HWV68_22015	COG0706	membrane insertase activity
HWV68_22020	COG0594	ribonuclease P activity