locus-tag class description DXY22_00002 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase DXY22_00003 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) DXY22_00004 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase DXY22_00005 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) DXY22_00006 ENOG4105ECC imidazole-glycerol-phosphate dehydratase DXY22_00007 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) DXY22_00008 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) DXY22_00009 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) DXY22_00011 ENOG4108E16 pectate lyase DXY22_00012 ENOG4108S4C acetyltransferase DXY22_00013 ENOG4107XGZ Hydrolase DXY22_00014 ENOG4105HKU nucleoside recognition domain-containing protein DXY22_00015 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) DXY22_00016 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) DXY22_00017 ENOG4105CE4 GlcNAc 6-P deacetylase DXY22_00018 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) DXY22_00020 ENOG41088CQ domain protein DXY22_00022 ENOG4106A3M Cytochrome p-450 DXY22_00023 ENOG410625E DXY22_00026 ENOG41086DT Membrane protein of unknown function DXY22_00027 ENOG41067S9 phage shock protein C, PspC DXY22_00028 ENOG4108PY7 DXY22_00032 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) DXY22_00033 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) DXY22_00036 ENOG4105MKU Transcriptional regulator DXY22_00040 ENOG4105CN1 protease DXY22_00041 ENOG4105CRP Part of the ABC transporter FtsEX involved in DXY22_00042 ENOG4105CAK Cell division ATP-binding protein ftsE DXY22_00045 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) DXY22_00047 ENOG4105MS2 ribosomal subunit Interface protein DXY22_00050 ENOG4105MQ3 flagellar protein FliS DXY22_00051 ENOG4107RT6 flagellar hook-associated DXY22_00052 ENOG41083S7 flagellar protein FlaG DXY22_00053 ENOG4105I03 Flagellin DXY22_00054 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) DXY22_00055 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) DXY22_00056 ENOG4105MKD DXY22_00057 ENOG4105DTJ flagellar hook-associated protein DXY22_00058 ENOG4105E1Q flagellar hook-associated protein DXY22_00061 ENOG4105RU3 DXY22_00062 ENOG41081UC Inherit from COG: Competence protein DXY22_00066 ENOG4105WH1 Two component transcriptional regulator luxr family DXY22_00067 ENOG4105BZU Histidine kinase DXY22_00068 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein DXY22_00069 ENOG4108KGH TRANSCRIPTIONal DXY22_00070 ENOG4105ESV Glycosyl transferase, family 4 DXY22_00071 ENOG4107EF8 Glycosyl transferase (Group 1 DXY22_00074 ENOG4105QZI O-Antigen Polymerase DXY22_00075 ENOG4105C6Y Udp-glucose 6-dehydrogenase DXY22_00076 ENOG4107RA4 Glycosyl transferase (Group 1 DXY22_00077 ENOG4105PSV Polysaccharide Biosynthesis Protein DXY22_00078 ENOG4105D3Q Sugar transferase DXY22_00080 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DXY22_00081 ENOG4105JFG SpoIID LytB domain protein DXY22_00084 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase DXY22_00088 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DXY22_00089 ENOG4105EY8 ABC transporter DXY22_00091 ENOG4107VDP teichoic acid biosynthesis DXY22_00092 ENOG41088M2 Glycosyl transferase family 2 DXY22_00102 ENOG4105DG6 mannose-6-phosphate isomerase DXY22_00105 ENOG4108NHD germination protein DXY22_00106 ENOG4105C54 Major Facilitator superfamily DXY22_00107 ENOG4108KGH TRANSCRIPTIONal DXY22_00108 ENOG4105J7I hydrolase DXY22_00109 ENOG4105K4H Nlp p60 protein DXY22_00111 ENOG4105PNM synthesis protein DXY22_00113 ENOG4105N98 Capsule biosynthesis protein capB DXY22_00114 ENOG4105ETE Transcriptional regulator (LacI family DXY22_00115 ENOG4108RVA ribokinase DXY22_00116 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) DXY22_00117 ENOG4105C2J ABC transporter DXY22_00118 ENOG4105CNN ABC, transporter DXY22_00119 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator DXY22_00122 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DXY22_00123 ENOG4107FQX Alpha-acetolactate decarboxylase DXY22_00125 ENOG4107RSM transcriptional regulator DXY22_00128 ENOG4106UIA DXY22_00131 ENOG4107XC4 flavin reductase domain protein, FMN-binding DXY22_00133 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DXY22_00135 ENOG4105CAH Chromate DXY22_00136 ENOG4105FGV Chromate DXY22_00138 ENOG4108WS4 fmn reductase DXY22_00139 ENOG4107V2S Transcriptional regulator DXY22_00140 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) DXY22_00145 ENOG4108XI2 Domain of unknown function (DUF1963) DXY22_00146 ENOG4105C6Y Udp-glucose 6-dehydrogenase DXY22_00147 ENOG4108RB3 Capsular polysaccharide biosynthesis protein DXY22_00148 ENOG4107YJ4 chain length determinant protein DXY22_00149 ENOG4105HTX biosynthesis protein DXY22_00151 ENOG4105KBK Zinc finger, swim domain protein DXY22_00152 ENOG4105C0D helicase DXY22_00153 ENOG410667J hydrolase DXY22_00154 ENOG4105E98 transcriptional regulator DeoR family DXY22_00155 ENOG4105Z8H single-stranded DNA-binding protein DXY22_00161 ENOG4108VAC response regulator DXY22_00164 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) DXY22_00165 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) DXY22_00167 ENOG4105CGA flagellar basal-body rod protein FlgG DXY22_00169 ENOG4105DFF Rod shape-determining protein mreb DXY22_00170 ENOG4105MT0 Sporulation transcriptional regulator spoiiid DXY22_00171 ENOG4107MII Sugar-specific transcriptional regulator TrmB DXY22_00172 ENOG4105CZM Major Facilitator DXY22_00173 ENOG4108M26 parallel beta-helix repeat protein DXY22_00174 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease DXY22_00175 ENOG41080V3 Major Facilitator superfamily DXY22_00176 ENOG4105D3W isochorismatase DXY22_00177 ENOG4107P26 DXY22_00178 ENOG4105BZU Histidine kinase DXY22_00180 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase DXY22_00184 ENOG4105FRN stage II sporulation protein DXY22_00185 ENOG4107TCE N-acetyltransferase DXY22_00188 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DXY22_00189 ENOG4107TXC Transcriptional regulator DXY22_00190 ENOG4106BRK DXY22_00191 ENOG4108RYK Nad-dependent epimerase dehydratase DXY22_00192 ENOG4108Z40 Transcriptional regulator DXY22_00193 ENOG4105CQM Urea amidohydrolase subunit alpha DXY22_00194 ENOG4105KI2 Urea amidohydrolase subunit beta DXY22_00195 ENOG4108YZ9 Urea amidohydrolase subunit gamma DXY22_00201 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) DXY22_00203 ENOG4108TF4 von Willebrand factor, type A DXY22_00205 ENOG4105JFG SpoIID LytB domain protein DXY22_00206 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DXY22_00208 ENOG4106778 Protein of unknown function (DUF1146) DXY22_00210 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) DXY22_00211 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) DXY22_00212 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) DXY22_00213 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) DXY22_00217 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) DXY22_00219 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) DXY22_00220 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) DXY22_00221 ENOG4108UIC UPF0340 protein DXY22_00222 ENOG4108YZG isomerase DXY22_00223 ENOG4107WAU Protein tyrosine phosphatase DXY22_00224 ENOG410815N Probably functions as a manganese efflux pump (By similarity) DXY22_00225 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DXY22_00227 ENOG4108ZXQ stage ii sporulation protein r DXY22_00230 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) DXY22_00231 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) DXY22_00232 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase DXY22_00234 ENOG4107TT2 Auxin Efflux Carrier DXY22_00235 ENOG4105C6K Malic enzyme DXY22_00236 ENOG4107104 thymidine kinase DXY22_00238 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) DXY22_00239 ENOG4105CBT Fructose-1,6-bisphosphatase DXY22_00240 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) DXY22_00241 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway DXY22_00242 ENOG4105D2N Aldolase DXY22_00243 ENOG410812K response regulator receiver protein DXY22_00245 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) DXY22_00247 ENOG4105C1G acyl-Coa dehydrogenase DXY22_00248 ENOG4105DF6 Fe-S oxidoreductase DXY22_00250 ENOG4105E5J UV damage endonuclease DXY22_00252 ENOG4105NAE bifunctional deaminase-reductase domain protein DXY22_00253 ENOG4105BZ1 (ABC) transporter DXY22_00254 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) DXY22_00256 ENOG4105R3A Nitrate reductase DXY22_00257 ENOG4108IUE nitrate reductase beta subunit DXY22_00261 ENOG4107V6Q Cyclic nucleotide-binding domain DXY22_00263 ENOG4105C75 arginyL-tRNA synthetase DXY22_00264 ENOG410684U Domain of unknown function (DUF1934) DXY22_00266 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E DXY22_00275 ENOG4107JM4 Tetratricopeptide repeat DXY22_00277 ENOG4108UIN ybak prolyl-trna synthetase associated region DXY22_00278 ENOG4105CYW agmatinase DXY22_00279 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) DXY22_00280 ENOG4105BZ4 penicillin-binding protein DXY22_00281 ENOG4108XFG YwhD family DXY22_00282 ENOG4108Z4T Peptidase M50 DXY22_00283 ENOG41069HH 4-oxalocrotonate tautomerase DXY22_00284 ENOG41067TZ transcriptional regulator, MarR family DXY22_00285 ENOG4105C22 threonyL-tRNA synthetase DXY22_00287 ENOG4105C57 major facilitator superfamily DXY22_00288 ENOG41062ES Transcriptional regulator DXY22_00290 ENOG4105DCI Phosphohydrolase DXY22_00292 ENOG4108VCI transcription factor, rsfa family DXY22_00293 ENOG4108RNG Permease of the drug metabolite transporter DXY22_00294 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) DXY22_00295 ENOG4105DUM transcriptional regulator, lysR family DXY22_00296 ENOG4108IJ2 phosphate acetyltransferase DXY22_00299 ENOG4105CHM Aminotransferase DXY22_00301 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase DXY22_00302 ENOG4105CHR reductase DXY22_00303 ENOG4106CHD Bacilysin biosynthesis protein bacB DXY22_00304 ENOG41061WN bacilysin biosynthesis protein DXY22_00305 ENOG4105FCW Major Facilitator superfamily DXY22_00308 ENOG4105C26 Dehydrogenase DXY22_00309 ENOG4105D82 Glutamate dehydrogenase DXY22_00311 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase DXY22_00312 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase DXY22_00313 ENOG4105C1B dTDP-glucose 4-6-dehydratase DXY22_00314 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) DXY22_00315 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG DXY22_00316 ENOG4107TY6 Acylneuraminate cytidylyltransferase DXY22_00318 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD DXY22_00319 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DXY22_00326 ENOG4105C26 Dehydrogenase DXY22_00327 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) DXY22_00328 ENOG4108RJ9 Glycosyl transferase, family 2 DXY22_00332 ENOG4105DWF phosphomethylpyrimidine kinase DXY22_00335 ENOG4105C5Y PTS System DXY22_00336 ENOG4108QTI )-transporter DXY22_00339 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin DXY22_00340 ENOG4105DEN Luciferase family DXY22_00341 ENOG4108DBC nitroreductase DXY22_00344 ENOG41060D1 Quinol oxidase DXY22_00345 ENOG4105CCU oxidase (Subunit III) DXY22_00346 ENOG4105BZ9 Cytochrome C oxidase, subunit I DXY22_00347 ENOG4105E2S oxidase) subunit II DXY22_00348 ENOG4107BMA Transglycosylase associated protein DXY22_00350 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) DXY22_00351 ENOG4105WH5 Teichoic acid glycosylation protein DXY22_00356 ENOG4107ZXU DSBA oxidoreductase DXY22_00357 ENOG4105DBE peroxidase DXY22_00358 ENOG410650H (LipO)protein DXY22_00359 ENOG4107SJW iron permease, FTR1 DXY22_00360 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) DXY22_00362 ENOG4105CMU LysR family (Transcriptional regulator DXY22_00363 ENOG4105VAW lrga family DXY22_00364 ENOG41067MG lrgb family DXY22_00365 ENOG4105D8G Major Facilitator superfamily DXY22_00367 ENOG4105DR4 Methyltransferase DXY22_00369 ENOG4108YV3 Protein of unknown function (DUF2711) DXY22_00370 ENOG4105CK1 PTS System DXY22_00371 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin DXY22_00374 ENOG4105X1N Glycosyl transferase family 8 DXY22_00376 ENOG4105GVJ transcriptional regulator DXY22_00377 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DXY22_00378 ENOG4105IIU Aminopeptidase DXY22_00383 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase DXY22_00385 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) DXY22_00386 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein DXY22_00388 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD DXY22_00389 ENOG4108VHC Short-chain dehydrogenase reductase Sdr DXY22_00390 ENOG4105CM2 brancheD-chain amino acid aminotransferase DXY22_00391 ENOG4105F8D glycoside hydrolase family 4 DXY22_00392 ENOG4105VCP PTS System DXY22_00393 ENOG4105CK1 PTS System DXY22_00394 ENOG4105VZJ PTS System DXY22_00395 ENOG4105EMD TRANSCRIPTIONal DXY22_00397 ENOG4108VX5 3-methyladenine DNA glycosylase DXY22_00398 ENOG4105CH6 catalase DXY22_00402 ENOG4105DA5 (ABC) transporter DXY22_00403 ENOG41069JR DXY22_00407 ENOG4105ETS cytosine purines uracil thiamine allantoin DXY22_00408 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) DXY22_00409 ENOG4108JJ8 (ABC) transporter DXY22_00410 ENOG4108JJ9 ABC, transporter DXY22_00411 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii DXY22_00412 ENOG4105C4M (Ubiquinol oxidase) subunit I DXY22_00413 ENOG4105D2K citrate carrier protein DXY22_00416 ENOG4107BJW polysaccharide deacetylase DXY22_00420 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) DXY22_00422 ENOG4105CMR udp-glucose 4-epimerase DXY22_00424 ENOG4105BZU Histidine kinase DXY22_00425 ENOG4105WH1 Two component transcriptional regulator luxr family DXY22_00426 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DXY22_00431 ENOG4105DTD Dehydrogenase DXY22_00432 ENOG4108IIH CoA-transferase subunit B DXY22_00433 ENOG4105D6N CoA-transferase, subunit a DXY22_00434 ENOG4105CY2 Citrate transporter DXY22_00435 ENOG4105DHI Methyltransferase DXY22_00439 ENOG4105CH6 catalase DXY22_00440 ENOG4105D4T Citrate transporter DXY22_00441 ENOG4108RZ2 Glycoside hydrolase family 16 DXY22_00442 ENOG4105CID antiterminator DXY22_00444 ENOG4105DEU major facilitator superfamily DXY22_00445 ENOG4105C1J atp-dependent rna helicase DXY22_00446 ENOG4107TDE lipolytic protein G-D-S-L family DXY22_00460 ENOG4107YZX Universal stress protein DXY22_00461 ENOG4105CS2 ec 3.2.1.21 DXY22_00462 ENOG4105C5Y PTS System DXY22_00464 ENOG4107EV6 Inherit from COG: YD repeat protein DXY22_00467 ENOG4106Z5D Glycoside Hydrolase Family 43 DXY22_00469 ENOG4105C84 Histidine ammonia-lyase DXY22_00470 ENOG4105CGP Urocanate hydratase DXY22_00471 ENOG4105CI2 imidazolone-5-propionate hydrolase DXY22_00472 ENOG4107W25 arginase agmatinase formiminoglutamase DXY22_00474 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) DXY22_00475 ENOG4105D9N nucleoside DXY22_00477 ENOG4107RHR regulatoR DXY22_00478 ENOG4108TM9 integral membrane protein DXY22_00479 ENOG4105ENY Ethanolamine utilization protein eutH DXY22_00480 ENOG4108PGP mmge prpd family protein DXY22_00483 ENOG4108HW4 amino acid AbC transporter DXY22_00484 ENOG4105EAB amino acid AbC transporter DXY22_00487 ENOG4107QHE Choloylglycine hydrolase DXY22_00488 ENOG410667J hydrolase DXY22_00494 ENOG4108V5C ABC transporter DXY22_00500 ENOG4105D2N Aldolase DXY22_00501 ENOG4107TRN Xylose isomerase domain protein TIM barrel DXY22_00502 ENOG4105F0H myo-inositol catabolism protein DXY22_00503 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) DXY22_00505 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) DXY22_00506 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) DXY22_00507 ENOG4105D7K pfkb domain protein DXY22_00509 ENOG4105C26 Dehydrogenase DXY22_00511 ENOG4105CPC Aldo Keto reductase DXY22_00514 ENOG4107QNK )-transporter DXY22_00515 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) DXY22_00517 ENOG41061TZ Short-chain dehydrogenase reductase Sdr DXY22_00518 ENOG4105ST3 Transcriptional regulator DXY22_00519 ENOG4105C26 Dehydrogenase DXY22_00520 ENOG4108YM7 Gcn5-related n-acetyltransferase DXY22_00521 ENOG4105N1N Cupin superfamily protein DXY22_00522 ENOG4107Y1Y Methyltransferase DXY22_00525 ENOG4105CAQ asparagine synthetase DXY22_00526 ENOG4105F22 Major Facilitator Superfamily DXY22_00527 ENOG4108ITS PQQ enzyme repeat DXY22_00529 ENOG41085PJ rdd domain containing protein DXY22_00532 ENOG4105J7D transcriptional regulator DXY22_00533 ENOG4107JEE Short-chain dehydrogenase reductase Sdr DXY22_00534 ENOG41061AU MarR family Transcriptional regulator DXY22_00536 ENOG41067MG lrgb family DXY22_00538 ENOG4105BZW Glycerate kinase DXY22_00539 ENOG4105G3Z GntR family transcriptional regulator DXY22_00540 ENOG4105CMG Carbohydrate kinase DXY22_00541 ENOG4105C6Z Gluconate DXY22_00542 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) DXY22_00543 ENOG4105D3R alkyl hydroperoxide reductase DXY22_00544 ENOG4108JU3 Alkyl hydroperoxide reductase DXY22_00546 ENOG4105CS2 ec 3.2.1.21 DXY22_00547 ENOG4105C5Y PTS System DXY22_00548 ENOG4108S3Y transcriptional regulator DXY22_00550 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 DXY22_00556 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) DXY22_00559 ENOG4105E2A Dehydrogenase DXY22_00563 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) DXY22_00564 ENOG4105WQG acetyltransferase DXY22_00565 ENOG410780I phosphoprotein phosphatase activity DXY22_00567 ENOG41066UZ arginase EC 3.5.3.1 DXY22_00568 ENOG4108IQI permease DXY22_00569 ENOG4105C8Y Acetylornithine aminotransferase DXY22_00570 ENOG4108JUB Transcriptional regulator DXY22_00571 ENOG4105BZU Histidine kinase DXY22_00575 ENOG4105C0H protease DXY22_00576 ENOG4105Q2H domain protein DXY22_00579 ENOG4105BZU Histidine kinase DXY22_00580 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DXY22_00585 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis DXY22_00586 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase DXY22_00587 ENOG4105CDU Replicative dna helicase DXY22_00591 ENOG4105DJ2 Major Facilitator Superfamily DXY22_00592 ENOG4105EDW glycosyl transferase, family 39 DXY22_00593 ENOG4105K9Q Binds to the 23S rRNA (By similarity) DXY22_00594 ENOG4105BZR domain protein DXY22_00595 ENOG4108XMW Membrane DXY22_00598 ENOG4105KVH Transcriptional regulator DXY22_00599 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase DXY22_00603 ENOG41090E6 transcriptional regulator MERR family DXY22_00605 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein DXY22_00606 ENOG4105DDN Pentapeptide repeat-containing protein DXY22_00607 ENOG4105D94 Major Facilitator Superfamily DXY22_00608 ENOG4107RSM transcriptional regulator DXY22_00609 ENOG41082BV acetyltransferase DXY22_00610 ENOG41081I9 integral membrane protein DXY22_00612 ENOG4108U05 Transcriptional regulator DXY22_00613 ENOG41082BV acetyltransferase DXY22_00615 ENOG4108U7W acetyltransferase DXY22_00616 ENOG4105UNS Pfam:DUF419 DXY22_00617 ENOG4105NAE bifunctional deaminase-reductase domain protein DXY22_00618 ENOG4108J8C transporter major facilitator family protein DXY22_00619 ENOG4105C7Z Conserved Protein DXY22_00623 ENOG4108IPJ Membrane DXY22_00624 ENOG4105C7Z Conserved Protein DXY22_00625 ENOG4107FCW Abortive infection protein DXY22_00627 ENOG4108UW5 maltose o-acetyltransferase DXY22_00628 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase DXY22_00630 ENOG4105CGK Exodeoxyribonuclease III DXY22_00631 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) DXY22_00632 ENOG4108UUM single-stranded DNA-binding protein DXY22_00633 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) DXY22_00634 ENOG4105C3G gtp-binding protein DXY22_00635 ENOG4108J2R molybdopterin oxidoreductase DXY22_00636 ENOG4105VDK protein, conserved in bacteria DXY22_00638 ENOG4108ZDA Sporulation protein YyaC DXY22_00639 ENOG4105FA0 parb-like partition protein DXY22_00640 ENOG4107QJE Chromosome Partitioning Protein DXY22_00643 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) DXY22_00644 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) DXY22_00645 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) DXY22_00648 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) DXY22_00649 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) DXY22_00650 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) DXY22_00651 ENOG410848D S4 domain protein YaaA DXY22_00654 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DXY22_00655 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DXY22_00662 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) DXY22_00664 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) DXY22_00665 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) DXY22_00666 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) DXY22_00668 ENOG4105ZMH deoxynucleoside kinase DXY22_00670 ENOG4105VRS hydrolase family 18 DXY22_00671 ENOG4105GTG Isochorismatase DXY22_00672 ENOG4108Z6B deaminase DXY22_00673 ENOG4105C6E dna polymerase iii DXY22_00674 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) DXY22_00675 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) DXY22_00677 ENOG41067KS pro-sigma K processing DXY22_00685 ENOG4105CDW Resistance protein DXY22_00686 ENOG4105CXN decarboxylase DXY22_00687 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) DXY22_00688 ENOG4105X0R protein from nitrogen regulatory protein P-II DXY22_00689 ENOG4105XVJ Protein of unknown function (DUF327) DXY22_00690 ENOG4105FA2 dna polymerase iii DXY22_00691 ENOG4105MA4 psp1 domain protein DXY22_00692 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) DXY22_00693 ENOG41060K3 Methyltransferase DXY22_00694 ENOG4105VC4 domain protein DXY22_00695 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) DXY22_00696 ENOG4105KRN Transcriptional regulator, abrb family DXY22_00697 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) DXY22_00698 ENOG4105F8V Hydrolase, tatD family DXY22_00699 ENOG41069ER domain protein DXY22_00701 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) DXY22_00702 ENOG4105XFA sporulation peptidase YabG DXY22_00703 ENOG4105W42 Veg protein DXY22_00704 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) DXY22_00705 ENOG4105DFT pur operon repressor DXY22_00706 ENOG4105KME endoribonuclease L-psp DXY22_00707 ENOG4105K4W Could be involved in septation (By similarity) DXY22_00708 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) DXY22_00709 ENOG4105C5T Phosphoribosyl pyrophosphate synthase DXY22_00710 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) DXY22_00711 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) DXY22_00713 ENOG4108JA2 transcriptioN-repair coupling factor DXY22_00714 ENOG4108M14 stage v sporulation protein t DXY22_00716 ENOG4108IY2 MazG family DXY22_00717 ENOG41082I2 s4 domain protein DXY22_00718 ENOG4105VYY sporulation protein yabp DXY22_00721 ENOG41060GV RNA binding s1 domain protein DXY22_00727 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) DXY22_00728 ENOG4108UGV hypoxanthine phosphoribosyltransferase DXY22_00729 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) DXY22_00731 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) DXY22_00732 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase DXY22_00733 ENOG4105C6T cysteine synthase DXY22_00734 ENOG4105CRQ synthase (Component I) DXY22_00735 ENOG4105DDQ anthranilate synthase DXY22_00736 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 DXY22_00737 ENOG4105EEI dihydropteroate synthase DXY22_00738 ENOG4105KRF dihydroneopterin aldolase DXY22_00739 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase DXY22_00741 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) DXY22_00742 ENOG4105CRK lysyL-tRNA synthetase DXY22_00759 ENOG4108Z0C Uvrb UvrC protein DXY22_00760 ENOG41066A3 ATP guanido phosphotransferase DXY22_00762 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) DXY22_00763 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) DXY22_00764 ENOG4105CTP PilT protein domain protein DXY22_00765 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) DXY22_00766 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) DXY22_00767 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) DXY22_00768 ENOG4105D7W serine acetyltransferase DXY22_00769 ENOG4105C8N cysteinyl-tRNA synthetase DXY22_00770 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) DXY22_00771 ENOG4105C2N RNA methyltransferase TrmH family group 3 DXY22_00772 ENOG4105M0M Tetracycline resistance protein DXY22_00775 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) DXY22_00778 ENOG4108VZM 50s ribosomal protein L10 DXY22_00780 ENOG4107Y49 methyltransferase DXY22_00781 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DXY22_00782 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DXY22_00783 ENOG4105XPM ribosomal protein DXY22_00784 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) DXY22_00785 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) DXY22_00786 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) DXY22_00787 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) DXY22_00788 ENOG4107SKW Inherit from COG: Alpha beta hydrolase DXY22_00789 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) DXY22_00790 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) DXY22_00791 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) DXY22_00793 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity DXY22_00796 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) DXY22_00797 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) DXY22_00799 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal DXY22_00800 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) DXY22_00802 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits DXY22_00804 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) DXY22_00805 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) DXY22_00806 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) DXY22_00807 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) DXY22_00809 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) DXY22_00810 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) DXY22_00812 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) DXY22_00814 ENOG41067V7 50S ribosomal protein L36 DXY22_00815 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits DXY22_00816 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) DXY22_00817 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) DXY22_00818 ENOG4108ZT0 50S ribosomal protein l17 DXY22_00819 ENOG4108JJB ABC transporter DXY22_00820 ENOG4108JJB ABC transporter DXY22_00821 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) DXY22_00822 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) DXY22_00823 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) DXY22_00824 ENOG4108UJD 30S ribosomal protein S9 DXY22_00825 ENOG4108I0C methyltransferase DXY22_00828 ENOG4105D1F ATP-binding protein DXY22_00831 ENOG4108NMV polysaccharide deacetylase DXY22_00844 ENOG4105CHH sulfate transporter DXY22_00847 ENOG4108SA1 esterase DXY22_00851 ENOG410874W AraC family transcriptional regulator DXY22_00852 ENOG4105EHZ conserved protein UCP016719 DXY22_00853 ENOG4105D17 glycoside hydrolase, family 3 domain protein DXY22_00857 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate DXY22_00859 ENOG4105EWC Purine nucleoside phosphorylase DXY22_00865 ENOG4105EMN RNA polymerase sigma factor DXY22_00867 ENOG4105C8B TIGR00159 family DXY22_00868 ENOG4107U5W ybbr family DXY22_00869 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) DXY22_00870 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) DXY22_00871 ENOG4105D03 DNA-3-methyladenine glycosylase II DXY22_00873 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DXY22_00874 ENOG4108TWJ NADH dehydrogenase subunit 5 DXY22_00879 ENOG4105GPN Uncharacterized conserved protein (DUF2294) DXY22_00880 ENOG4105WAB arsR family transcriptional regulator DXY22_00881 ENOG4108RWP Major Facilitator Superfamily protein DXY22_00883 ENOG4107ZBH radical SAM domain protein DXY22_00884 ENOG41066N6 Abortive infection protein DXY22_00885 ENOG4108WUZ (ABC) transporter DXY22_00893 ENOG4105G0J serine threonine protein kinase DXY22_00895 ENOG4106K80 DXY22_00897 ENOG4106DDH Sporulation-specific SASP protein DXY22_00899 ENOG4108HWY Beta-lactamase DXY22_00900 ENOG4107E6A Cytochrome p-450 DXY22_00902 ENOG4107QTZ amino acid DXY22_00903 ENOG4107VXM glycerophosphoryl diester phosphodiesterase DXY22_00904 ENOG4105CXY transporter DXY22_00906 ENOG410645S MarR family Transcriptional regulator DXY22_00907 ENOG4105DCM major facilitator superfamily DXY22_00910 ENOG410631K Membrane DXY22_00911 ENOG4106AXJ AraC family transcriptional regulator DXY22_00912 ENOG41065RQ ADP-ribosylation crystallin J1 DXY22_00913 ENOG4106BHF DXY22_00914 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR DXY22_00915 ENOG4108TCS Glutamyl endopeptidase DXY22_00917 ENOG4108WC5 Alpha Beta Hydrolase Fold protein DXY22_00918 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase DXY22_00919 ENOG4107ZTW SNARE associated Golgi DXY22_00923 ENOG4105C72 UPF0176 protein DXY22_00925 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane DXY22_00926 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) DXY22_00929 ENOG4105CM2 brancheD-chain amino acid aminotransferase DXY22_00930 ENOG4108IQI permease DXY22_00931 ENOG4108J5H Homocysteine s-methyltransferase DXY22_00933 ENOG4105CSV Glutaminase DXY22_00936 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase DXY22_00937 ENOG4105C26 Dehydrogenase DXY22_00938 ENOG4105DJB Major Facilitator Superfamily DXY22_00939 ENOG4105EQX glucarate dehydratase DXY22_00940 ENOG41073TP transcriptional regulator DXY22_00941 ENOG4105CTX dehydratase DXY22_00944 ENOG4106UX7 integral membrane protein DXY22_00945 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DXY22_00951 ENOG4105MUA Resistance protein DXY22_00952 ENOG4105DGI Alkaline phosphatase DXY22_00953 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) DXY22_00954 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DXY22_00955 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) DXY22_00956 ENOG4107EPV Aminotransferase class V DXY22_00957 ENOG4105C0R drug resistance transporter emrb qaca subfamily DXY22_00958 ENOG4105J7D transcriptional regulator DXY22_00959 ENOG4107RB3 L-asparaginase DXY22_00960 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold DXY22_00962 ENOG41060AI SEC-C motif DXY22_00964 ENOG4107Y7X LytTR DXY22_00965 ENOG4108IUW ABC transporter DXY22_00966 ENOG4108SDH ABC, transporter DXY22_00967 ENOG4107SET aldo keto reductase DXY22_00973 ENOG4105H9W Short-chain dehydrogenase reductase Sdr DXY22_00975 ENOG4105DSE periplasmic solute binding protein DXY22_00976 ENOG4105DIK (ABC) transporter DXY22_00978 ENOG4105DEN Luciferase family DXY22_00979 ENOG4108N0M stress protein DXY22_00980 ENOG4106FN3 tellurium resistance protein DXY22_00981 ENOG4106FN3 tellurium resistance protein DXY22_00982 ENOG4107TS3 membrane protein, TerC DXY22_00983 ENOG4108TTB tellurium resistance protein DXY22_00985 ENOG41079KZ Major Facilitator Superfamily DXY22_00986 ENOG4107XZQ multidrug resistance protein DXY22_00987 ENOG4108A65 Transcriptional regulator DXY22_00988 ENOG4108IJ7 Glycine betaine DXY22_00989 ENOG4107SQ8 Glycine betaine DXY22_00995 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DXY22_01002 ENOG4105EIG urea carboxylase-associated protein 1 DXY22_01003 ENOG4107RA1 nh(3)-dependent nad( ) synthetase DXY22_01004 ENOG4105I1F Resistance protein DXY22_01006 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) DXY22_01007 ENOG41089UC methyltransferase, type 11 DXY22_01008 ENOG4105C5Q Transcriptional regulator DXY22_01009 ENOG4105I82 acetyl xylan esterase DXY22_01010 ENOG410756H nucleotidyltransferase DXY22_01012 ENOG4105C26 Dehydrogenase DXY22_01013 ENOG4105CK7 Sodium proline symporter DXY22_01014 ENOG4107YHD transcriptional regulator DXY22_01016 ENOG4108PJD permease DXY22_01017 ENOG4105U6C Alpha beta hydrolase fold protein DXY22_01019 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DXY22_01020 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit DXY22_01021 ENOG4108IFG nitrite reductase, (NAD(P)H) DXY22_01022 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) DXY22_01026 ENOG4105S7A ErfK ybiS ycfS ynhG family protein DXY22_01027 ENOG4105CKI cobalamin synthesis protein DXY22_01028 ENOG4105E5Q amino acid AbC transporter DXY22_01029 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein DXY22_01031 ENOG4105K56 Transcriptional regulator DXY22_01035 ENOG4105CS2 ec 3.2.1.21 DXY22_01038 ENOG4105C8Q Methyl-accepting chemotaxis DXY22_01039 ENOG41080HJ 6-phospho 3-hexuloisomerase DXY22_01040 ENOG4108VA3 3-hexulose-6-phosphate synthase DXY22_01041 ENOG4105KVH Transcriptional regulator DXY22_01042 ENOG4105CEY Amp-dependent synthetase and ligase DXY22_01048 ENOG4105SX7 Transporter DXY22_01050 ENOG4105W8Z 4'-phosphopantetheinyl transferase DXY22_01052 ENOG4105CDA abc transporter atp-binding protein DXY22_01053 ENOG4105DRP amino acid AbC transporter DXY22_01055 ENOG4106P55 Transcriptional regulator DXY22_01056 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase DXY22_01057 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) DXY22_01058 ENOG41069ZX DXY22_01059 ENOG41069ZX DXY22_01061 ENOG4105DUX Transporter DXY22_01064 ENOG4105E1K spore germination protein DXY22_01068 ENOG4107WD8 ABC transporter, permease DXY22_01069 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DXY22_01070 ENOG4105BZU Histidine kinase DXY22_01075 ENOG4105CFH Aspartokinase DXY22_01076 ENOG4105DHS permease protein DXY22_01077 ENOG4105CM4 permease protein DXY22_01078 ENOG4108IPW abc transporter atp-binding protein DXY22_01081 ENOG4105R8C Transcriptional regulator DXY22_01082 ENOG4108DBC nitroreductase DXY22_01083 ENOG41067V3 Antibiotic biosynthesis monooxygenase DXY22_01084 ENOG4105YVS arsR family transcriptional regulator DXY22_01086 ENOG4108JPW Aminotransferase DXY22_01087 ENOG4105C26 Dehydrogenase DXY22_01089 ENOG4105H9W Short-chain dehydrogenase reductase Sdr DXY22_01090 ENOG4105KTB nuclear export factor GLE1 DXY22_01091 ENOG4108T5E Copper resistance protein DXY22_01092 ENOG4108ZYE Transcriptional regulator DXY22_01097 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DXY22_01098 ENOG4108ZX0 Signal peptidase I DXY22_01103 ENOG4105E7W lamb ycsf family protein DXY22_01104 ENOG4105C5A transporter DXY22_01105 ENOG4105CFM UPF0317 protein DXY22_01106 ENOG4105P4J Allophanate hydrolase, subunit 1 DXY22_01108 ENOG4107258 Transcriptional regulator DXY22_01109 ENOG4105XJB lipolytic protein G-D-S-L family DXY22_01111 ENOG41061CK Antibiotic biosynthesis monooxygenase DXY22_01112 ENOG4107RVG penicillin-binding protein DXY22_01113 ENOG4107QM2 Aldo Keto reductase DXY22_01114 ENOG4105ETD TRANSCRIPTIONal DXY22_01116 ENOG4105HMZ Methyltransferase DXY22_01117 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DXY22_01120 ENOG410606W general stress protein DXY22_01122 ENOG4105VCH membrane DXY22_01124 ENOG4105C9U ATP-dependent DNA helicase RecQ DXY22_01127 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) DXY22_01128 ENOG4107R8N Glycosyl transferase, family 2 DXY22_01130 ENOG4105C0X amino acid DXY22_01134 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) DXY22_01136 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) DXY22_01137 ENOG4105EU9 DXY22_01138 ENOG4105QVS general stress protein DXY22_01139 ENOG41082W1 Cupin 2, conserved barrel domain protein DXY22_01142 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit DXY22_01143 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism DXY22_01144 ENOG4108MRH transcriptional regulatory protein DXY22_01145 ENOG4107QJT sodium dicarboxylate symporter DXY22_01146 ENOG4106F5Q Membrane DXY22_01147 ENOG4105CJ1 ABC, transporter DXY22_01150 ENOG4105FDT acyl-CoA dehydrogenase DXY22_01154 ENOG4105SZ6 Thioredoxin DXY22_01155 ENOG4105CPF Cell wall formation (By similarity) DXY22_01156 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) DXY22_01157 ENOG4105C1J atp-dependent rna helicase DXY22_01158 ENOG410905X membrane-flanked domain protein DXY22_01159 ENOG4105CKV Membrane DXY22_01161 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) DXY22_01162 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein DXY22_01163 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DXY22_01165 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) DXY22_01166 ENOG4107MMM Anti-sigma-factor antagonist DXY22_01167 ENOG4105FUA antagonist DXY22_01168 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase DXY22_01169 ENOG4107SGM protein serine threonine phosphatase DXY22_01170 ENOG4105WN5 stage II sporulation protein DXY22_01171 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) DXY22_01173 ENOG41064BQ Phosphatase DXY22_01193 ENOG4105VZ8 Transcriptional regulator DXY22_01198 ENOG4108V4B ThiJ pfpI DXY22_01199 ENOG4105VEQ Cold shock protein DXY22_01200 ENOG4108VJ1 Transcriptional regulator (CarD family DXY22_01202 ENOG4108MCI Transcriptional regulator, ARAC family DXY22_01203 ENOG4108UZ3 Transporter DXY22_01204 ENOG41086D8 Transcriptional regulator DXY22_01205 ENOG4107U9B transcriptional regulator DXY22_01206 ENOG4105DXI Major Facilitator superfamily DXY22_01208 ENOG4105CZ9 Domain of unknown function (DU1801) DXY22_01209 ENOG4105GIG DXY22_01211 ENOG4105KRI phosphocarrier protein (HPr DXY22_01212 ENOG4105ST3 Transcriptional regulator DXY22_01213 ENOG4105T38 integral membrane protein DXY22_01214 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DXY22_01215 ENOG4108ZMQ domain protein DXY22_01216 ENOG4105MJ9 esterase DXY22_01217 ENOG4107Z6X Transcriptional regulator DXY22_01219 ENOG4105KVH Transcriptional regulator DXY22_01220 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DXY22_01221 ENOG4105EQ0 Major Facilitator superfamily DXY22_01222 ENOG4108JGH Tetr family transcriptional regulator DXY22_01223 ENOG41082YX Transcriptional regulator, arsr family DXY22_01224 ENOG4107R5R arsenical pump membrane protein DXY22_01225 ENOG4105Z7P Acetyltransferase (GNAT) family DXY22_01226 ENOG4107Y9U Membrane DXY22_01228 ENOG4108SQ9 flavin reductase domain protein, FMN-binding DXY22_01229 ENOG4108ZHR arsR family transcriptional regulator DXY22_01230 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) DXY22_01232 ENOG4105ENE Histidine kinase DXY22_01233 ENOG4108VB1 regulatoR DXY22_01234 ENOG4105EYF MMPL domain protein DXY22_01235 ENOG4108WC5 Alpha Beta Hydrolase Fold protein DXY22_01236 ENOG4108UQV Membrane DXY22_01237 ENOG4108Z5V transcriptional regulator, merr family DXY22_01238 ENOG41076HS cation diffusion facilitator family transporter DXY22_01239 ENOG4108TVJ Nitroreductase DXY22_01240 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase DXY22_01241 ENOG4108VGI doxx family DXY22_01242 ENOG4105XXY Thioredoxin DXY22_01246 ENOG410900G Protein of unknown function (DUF421) DXY22_01247 ENOG4108QY0 Membrane DXY22_01251 ENOG4105PF9 Transcriptional regulator DXY22_01253 ENOG4105WQG acetyltransferase DXY22_01255 ENOG4105C85 amino acid DXY22_01257 ENOG41062A4 Transcriptional regulator DXY22_01258 ENOG4105EYF MMPL domain protein DXY22_01259 ENOG4108TVJ Nitroreductase DXY22_01260 ENOG4105FS7 Transcriptional regulator DXY22_01261 ENOG4105C2C drug resistance transporter, Bcr CflA DXY22_01263 ENOG4105DRR Transcriptional regulator, GntR family DXY22_01264 ENOG4105VRS hydrolase family 18 DXY22_01267 ENOG4105G6Z alkaline phosphatase DXY22_01268 ENOG4108ZMX Domain of unknown function (DU1801) DXY22_01270 ENOG4108YM7 Gcn5-related n-acetyltransferase DXY22_01271 ENOG4107TVP HD domain protein DXY22_01272 ENOG41090UD (LipO)protein DXY22_01273 ENOG4105F27 Major Facilitator DXY22_01274 ENOG4105VZJ PTS System DXY22_01275 ENOG4105VCP PTS System DXY22_01276 ENOG4105CK1 PTS System DXY22_01277 ENOG4105CS2 ec 3.2.1.21 DXY22_01278 ENOG4108TZY GntR Family Transcriptional Regulator DXY22_01279 ENOG4105EVU fructokinase DXY22_01280 ENOG4105DG6 mannose-6-phosphate isomerase DXY22_01281 ENOG4105D3P Mannan endo-1,4-beta-mannosidase DXY22_01290 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) DXY22_01291 ENOG4105K8N protein family UPF0079, ATPase DXY22_01292 ENOG41072GX Peptidase M22 Glycoprotease DXY22_01293 ENOG410801F ribosomal-protein-alanine acetyltransferase DXY22_01294 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) DXY22_01295 ENOG4105C5H ABC transporter DXY22_01296 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) DXY22_01297 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) DXY22_01298 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) DXY22_01299 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) DXY22_01301 ENOG4108TYN CAAX amino terminal protease family protein DXY22_01303 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) DXY22_01305 ENOG4105PGZ NB-ARC domain DXY22_01306 ENOG4105CPQ Dehydrogenase DXY22_01307 ENOG4105CT4 transporter DXY22_01309 ENOG41087YS Phage shock protein A DXY22_01310 ENOG4105DQX Zinc finger domain DXY22_01311 ENOG4108WV1 Pfam:DUF477 DXY22_01313 ENOG4108ZMR Ion transport 2 domain-containing protein DXY22_01314 ENOG4107QNK )-transporter DXY22_01320 ENOG4107YUH hydrolase DXY22_01322 ENOG4107STQ Multicopper oxidase DXY22_01323 ENOG4105C85 amino acid DXY22_01325 ENOG4105C7R Atpase associated with various cellular activities aaa_3 DXY22_01331 ENOG4105C7N Xanthine uracil vitamin C permease DXY22_01336 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) DXY22_01337 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit DXY22_01338 ENOG4105C83 adenylosuccinate lyase DXY22_01339 ENOG4105C8V SAICAR synthetase DXY22_01340 ENOG4105VR9 phosphoribosylformylglycinamidine synthase DXY22_01341 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I DXY22_01342 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii DXY22_01344 ENOG4105CXB phosphoribosylaminoimidazole synthetase DXY22_01345 ENOG4108V3E phosphoribosylglycinamide formyltransferase DXY22_01346 ENOG4105DC1 bifunctional purine biosynthesis protein purh DXY22_01347 ENOG4105C12 Phosphoribosylglycinamide synthetase DXY22_01349 ENOG4105DVH amino acid DXY22_01352 ENOG4108R5T secreted protein DXY22_01353 ENOG4105KGF protein, YerC YecD DXY22_01354 ENOG4105CBC glutamate synthase DXY22_01355 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) DXY22_01356 ENOG4105C4R Atp-dependent dna helicase DXY22_01357 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) DXY22_01359 ENOG4105CRN Aminoglycoside phosphotransferase DXY22_01360 ENOG4105KT7 mgtC SapB transporter DXY22_01361 ENOG4105CK7 Sodium proline symporter DXY22_01362 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DXY22_01363 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) DXY22_01364 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) DXY22_01365 ENOG4108IG5 Transcriptional regulator DXY22_01367 ENOG4105CBD Diacylglycerol kinase DXY22_01368 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DXY22_01370 ENOG4105CVR type I restriction-modification system DXY22_01372 ENOG4105DZR Type I site-specific deoxyribonuclease DXY22_01384 ENOG4105CDY transcriptional regulatory protein DXY22_01386 ENOG4105M4P Tetr family transcriptional regulator DXY22_01387 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein DXY22_01388 ENOG4107S9F NmrA family DXY22_01391 ENOG4105WEF catalase DXY22_01392 ENOG4105M18 -acetyltransferase DXY22_01394 ENOG4105C2F Histidine kinase DXY22_01395 ENOG4105EQD regulatoR DXY22_01396 ENOG410769Z extracellular solute-binding protein family 1 DXY22_01397 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component DXY22_01398 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component DXY22_01399 ENOG4105F5H Glycosyl Hydrolase Family 88 DXY22_01400 ENOG41075H3 AraC family transcriptional regulator DXY22_01401 ENOG4107TDE lipolytic protein G-D-S-L family DXY22_01404 ENOG4105CX8 fg-gap repeat protein DXY22_01405 ENOG4105CX8 fg-gap repeat protein DXY22_01406 ENOG4107TDE lipolytic protein G-D-S-L family DXY22_01408 ENOG4105EKC DXY22_01409 ENOG4105E0S extracellular solute-binding protein family 1 DXY22_01411 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component DXY22_01412 ENOG4105F8D glycoside hydrolase family 4 DXY22_01413 ENOG4105H67 Protein of unknown function (DUF421) DXY22_01414 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) DXY22_01415 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DXY22_01419 ENOG4106I4J membrane DXY22_01420 ENOG41082F9 transcriptional regulator DXY22_01421 ENOG41061H0 Monooxygenase DXY22_01422 ENOG4108R1P DXY22_01423 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DXY22_01424 ENOG4105E0M Sulfatase DXY22_01425 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase DXY22_01427 ENOG41090R9 glycosyltransferase DXY22_01428 ENOG4107R51 Glycosyl transferase, family 2 DXY22_01429 ENOG41090R9 glycosyltransferase DXY22_01430 ENOG4105EU0 Major facilitator Superfamily DXY22_01432 ENOG4105CUB amino acid DXY22_01433 ENOG4105C26 Dehydrogenase DXY22_01434 ENOG4105FKZ Methyl-accepting chemotaxis DXY22_01435 ENOG4105C5H ABC transporter DXY22_01437 ENOG4107SWG transcriptional regulator MERR family DXY22_01438 ENOG4105DXB Major Facilitator superfamily DXY22_01439 ENOG4105C5H ABC transporter DXY22_01440 ENOG4105FDU atp-dependent rna helicase DXY22_01442 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein DXY22_01444 ENOG4105E6M Sulphatase-modifying factor protein DXY22_01445 ENOG4105E0A ABC, transporter DXY22_01446 ENOG4108U1V ABC transporter, permease DXY22_01447 ENOG4105DQ5 transport system permease protein DXY22_01448 ENOG4108HUF Transporter DXY22_01451 ENOG4108J20 pectate lyase DXY22_01452 ENOG4107QPK )-transporter DXY22_01454 ENOG4108MRH transcriptional regulatory protein DXY22_01459 ENOG410855V Acylphosphatase DXY22_01460 ENOG4108RPX mosc domain containing protein DXY22_01464 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) DXY22_01469 ENOG4105E1K spore germination protein DXY22_01470 ENOG4105C5Y PTS System DXY22_01471 ENOG4105CG3 alpha amylase, catalytic region DXY22_01472 ENOG4107414 GntR family transcriptional regulator DXY22_01473 ENOG4108RCM Nitroreductase DXY22_01474 ENOG4105CGH 5'-nucleotidase DXY22_01475 ENOG4107RKG DJ-1/PfpI family DXY22_01478 ENOG4105KJF protein tyrosine phosphatase DXY22_01480 ENOG4107U9T Pfam:Ribonuclease_BN DXY22_01481 ENOG4108ISG Major Facilitator DXY22_01482 ENOG4105UPD Calcium Proton DXY22_01484 ENOG4105D8X mechanosensitive ion channel DXY22_01488 ENOG4106KE4 Dehydrogenase DXY22_01489 ENOG4105D7N magnesium and cobalt transport protein CorA DXY22_01491 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) DXY22_01496 ENOG4107RUY (E1 component), alpha subunit DXY22_01498 ENOG4107QKR Dehydrogenase DXY22_01500 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family DXY22_01501 ENOG41069DP small acid-soluble spore protein DXY22_01502 ENOG4105KK4 UPF0060 membrane protein DXY22_01507 ENOG4105F8D glycoside hydrolase family 4 DXY22_01508 ENOG4108Q3X Transcriptional regulator DXY22_01509 ENOG4105CI1 PTS System DXY22_01510 ENOG4105BZ1 (ABC) transporter DXY22_01511 ENOG4105BZ1 (ABC) transporter DXY22_01513 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase DXY22_01515 ENOG4105BZU Histidine kinase DXY22_01516 ENOG4105WH1 Two component transcriptional regulator luxr family DXY22_01517 ENOG4105CJ1 ABC, transporter DXY22_01518 ENOG41090VJ ABC-2 type transporter DXY22_01519 ENOG4108KYE ABC-2 type transporter DXY22_01520 ENOG4105U3E Transcriptional regulator DXY22_01521 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold DXY22_01522 ENOG4105H93 Acyltransferase family DXY22_01523 ENOG4108YYS metal-dependent hydrolase (By similarity) DXY22_01524 ENOG4105C0R drug resistance transporter emrb qaca subfamily DXY22_01525 ENOG410834F Transcriptional regulator DXY22_01527 ENOG4108MES Periplasmic binding protein DXY22_01528 ENOG4105DQ5 transport system permease protein DXY22_01529 ENOG4108IHU transport system permease protein DXY22_01530 ENOG4105JAB phenazine biosynthesis protein, phzf family DXY22_01531 ENOG4107Y03 Nitroreductase DXY22_01534 ENOG4105ECP epimerase DXY22_01538 ENOG4105F27 Major Facilitator DXY22_01542 ENOG4106AKJ DXY22_01543 ENOG4105D74 hydrolase DXY22_01544 ENOG4105CKK Glycosyl transferase, family 2 DXY22_01545 ENOG4105EJV Membrane DXY22_01546 ENOG41067AE Membrane-bound metal-dependent hydrolase DXY22_01547 ENOG4105CEN a g-specific adenine glycosylase DXY22_01548 ENOG4106BXE DXY22_01549 ENOG4105CAN Short-chain dehydrogenase reductase Sdr DXY22_01552 ENOG4105EVI UPF0374 protein DXY22_01553 ENOG4105BZ1 (ABC) transporter DXY22_01554 ENOG4107NBY Membrane DXY22_01556 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DXY22_01557 ENOG4105G5W regulator Fur family DXY22_01579 ENOG4108N23 SpoOM-related protein DXY22_01581 ENOG4105EC3 peptidase S51, dipeptidase E DXY22_01582 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) DXY22_01583 ENOG4105DNP FAD linked oxidase domain protein DXY22_01586 ENOG4105E2Y ABC, transporter DXY22_01587 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein DXY22_01588 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component DXY22_01589 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) DXY22_01591 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) DXY22_01592 ENOG4107D63 DXY22_01593 ENOG4105VZ8 Transcriptional regulator DXY22_01596 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) DXY22_01598 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) DXY22_01602 ENOG4105CYN Serine protein kinase DXY22_01603 ENOG4106AKX UPF0229 protein DXY22_01604 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes DXY22_01605 ENOG4105CW7 secretion protein, HlyD family DXY22_01606 ENOG4105C0R drug resistance transporter emrb qaca subfamily DXY22_01607 ENOG4105CS1 NAD(P)H quinone oxidoreductase DXY22_01610 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family DXY22_01611 ENOG4105CZV ABC transporter DXY22_01612 ENOG4105CJ1 ABC, transporter DXY22_01613 ENOG4108TU7 Inherit from COG: (ABC) transporter DXY22_01614 ENOG4105VEQ Cold shock protein DXY22_01616 ENOG4105BZU Histidine kinase DXY22_01624 ENOG4108YBP pseudouridine synthase DXY22_01626 ENOG41080XP Cbs domain DXY22_01627 ENOG4107YBY Hydrolase DXY22_01628 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DXY22_01629 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DXY22_01630 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator DXY22_01632 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) DXY22_01633 ENOG4105C6V Glycerol-3-phosphate dehydrogenase DXY22_01635 ENOG4105BZU Histidine kinase DXY22_01636 ENOG4105WH1 Two component transcriptional regulator luxr family DXY22_01643 ENOG4105ED1 spovr family DXY22_01644 ENOG4105G6Z alkaline phosphatase DXY22_01647 ENOG4105BZN citrate synthase DXY22_01648 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DXY22_01649 ENOG4105CUB amino acid DXY22_01650 ENOG4105C8J )-transporter DXY22_01651 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DXY22_01654 ENOG4105J37 DXY22_01655 ENOG4108AEY RNA polymerase sigma factor DXY22_01656 ENOG4108FN7 Aldo keto reductase DXY22_01657 ENOG4105F6E Acyl-transferase DXY22_01658 ENOG4105C37 (CBS) domain DXY22_01660 ENOG4105CHM Aminotransferase DXY22_01661 ENOG4105C37 (CBS) domain DXY22_01663 ENOG4105WMR Protein CrcB homolog DXY22_01664 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DXY22_01666 ENOG4105D64 Mechanosensitive ion channel DXY22_01667 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) DXY22_01668 ENOG4107VMI polysaccharide deacetylase DXY22_01669 ENOG4105F0I Aminotransferase DXY22_01672 ENOG4105BZ1 (ABC) transporter DXY22_01673 ENOG4105BZ1 (ABC) transporter DXY22_01677 ENOG410839P DXY22_01679 ENOG4106MP8 UPF0754 membrane protein DXY22_01680 ENOG4105WZB UPF0342 protein DXY22_01681 ENOG4105F1N DNA alkylation repair DXY22_01683 ENOG4105D4P Coproporphyrinogen iii oxidase DXY22_01684 ENOG4107S91 Sodium hydrogen exchanger DXY22_01685 ENOG4105NCW Trka-c domain protein DXY22_01687 ENOG4105CGU Enoyl-CoA hydratase DXY22_01689 ENOG4108IUX (ABC) transporter DXY22_01690 ENOG4105RHA ABC transporter, permease DXY22_01691 ENOG4107VRP DNA repair exonuclease DXY22_01692 ENOG4106D4I domain protein DXY22_01693 ENOG4105EQI Metal Dependent Phosphohydrolase DXY22_01695 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) DXY22_01700 ENOG4105NBU tryptophan transport protein DXY22_01701 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) DXY22_01702 ENOG4105K59 histidine triad (HIT) protein DXY22_01709 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation DXY22_01710 ENOG4105BZ4 penicillin-binding protein DXY22_01711 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) DXY22_01712 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) DXY22_01713 ENOG4105C1Q protoporphyrinogen oxidase DXY22_01715 ENOG4105ECB domain protein DXY22_01717 ENOG41090T1 Membrane DXY22_01718 ENOG4105DER m42 family DXY22_01721 ENOG4108RQ5 Beta-lactamase domain-containing protein DXY22_01722 ENOG4105DF9 Lipoate-protein, ligase DXY22_01724 ENOG4105CEY Amp-dependent synthetase and ligase DXY22_01726 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 DXY22_01728 ENOG4105KD7 acetyltransferase DXY22_01730 ENOG4108HUF Transporter DXY22_01731 ENOG4107TB6 phosphoglycerate mutase DXY22_01733 ENOG4107F3J Amp-dependent synthetase and ligase DXY22_01734 ENOG4107ZYJ bioY protein DXY22_01735 ENOG4106YBV Methyl-accepting chemotaxis DXY22_01739 ENOG4105XVF Competence transcription factor DXY22_01740 ENOG4105CYX Short-chain dehydrogenase reductase Sdr DXY22_01741 ENOG4105X3H Excalibur domain protein DXY22_01742 ENOG4105E1V na solute symporter DXY22_01743 ENOG4106CAD Protein of unknown function (DUF3311) DXY22_01744 ENOG41060YP DXY22_01747 ENOG4107SCK Monooxygenase DXY22_01748 ENOG4108INS Transcriptional regulator DXY22_01751 ENOG4105TRI Hydrolase DXY22_01754 ENOG4108KK1 membrane protein AbrB duplication DXY22_01755 ENOG4106K7D Major facilitator family transporter DXY22_01756 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) DXY22_01757 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding DXY22_01760 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation DXY22_01762 ENOG4105EYH Exonuclease DXY22_01772 ENOG4105ERH Fumarylacetoacetate hydrolase DXY22_01774 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin DXY22_01776 ENOG4105CAQ asparagine synthetase DXY22_01779 ENOG4105UQX Mate efflux family protein DXY22_01780 ENOG4106HBX Transcriptional Regulator AraC Family DXY22_01781 ENOG4105ETE Transcriptional regulator (LacI family DXY22_01782 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) DXY22_01783 ENOG4105SF0 DinB family DXY22_01784 ENOG4108ZUB Lysine exporter protein (Lyse ygga) DXY22_01785 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family DXY22_01786 ENOG4105MYW Pentapeptide repeat protein DXY22_01787 ENOG4107S9D Alpha beta hydrolase DXY22_01788 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) DXY22_01789 ENOG4107RIQ Sulfate adenylate transferase DXY22_01790 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) DXY22_01791 ENOG4108N5B 2-phosphosulfolactate phosphatase DXY22_01792 ENOG41061P3 phosphosulfolactate synthase DXY22_01794 ENOG4105DIA mandelate racemase muconate lactonizing DXY22_01795 ENOG4107RCC Major Facilitator Superfamily DXY22_01796 ENOG4108SZE gCN5-related N-acetyltransferase DXY22_01797 ENOG4105MA6 gCN5-related N-acetyltransferase DXY22_01799 ENOG4108VPT UPF0234 protein DXY22_01800 ENOG4105QNR S1 RNA binding domain protein DXY22_01804 ENOG4105K7K Transcriptional regulator DXY22_01806 ENOG410751J DXY22_01807 ENOG4105D4Y metalloprotease DXY22_01808 ENOG4105EPR degv family DXY22_01809 ENOG4107AYK membrAne DXY22_01811 ENOG41073B9 DXY22_01813 ENOG4108KP7 hydrolase DXY22_01814 ENOG4108MXZ Esterase DXY22_01815 ENOG4105VG1 fes assembly suf system protein DXY22_01817 ENOG4105IQ5 FAD linked oxidase domain protein DXY22_01818 ENOG4105IQ5 FAD linked oxidase domain protein DXY22_01820 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase DXY22_01821 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) DXY22_01823 ENOG4105C8Y Acetylornithine aminotransferase DXY22_01824 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DXY22_01826 ENOG4105DBV ornithine carbamoyltransferase DXY22_01831 ENOG4107RMD Basic membrane lipoprotein DXY22_01834 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) DXY22_01835 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) DXY22_01837 ENOG4105C3U ABC transporter DXY22_01838 ENOG4108JQ7 (ABC) transporter DXY22_01841 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DXY22_01843 ENOG4105C31 Tryptophanyl-tRNA synthetase DXY22_01844 ENOG4108J59 Extracellular solute-binding protein, family 5 DXY22_01845 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DXY22_01846 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DXY22_01848 ENOG4108JQ7 (ABC) transporter DXY22_01851 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) DXY22_01852 ENOG4108ZCF integral membrane protein DXY22_01853 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis DXY22_01855 ENOG4105DPN Oligoendopeptidase f DXY22_01858 ENOG4105T58 Dithiol-disulfide isomerase DXY22_01859 ENOG4108Z18 K06886 hemoglobin DXY22_01860 ENOG4105E4C Lytic transglycosylase catalytic DXY22_01861 ENOG4105MIX Adenylate cyclase DXY22_01864 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DXY22_01865 ENOG4105EMS pseudouridine synthase DXY22_01868 ENOG4105ETU transcriptional activator (TenA DXY22_01869 ENOG4108VEU Thiamine monophosphate synthase DXY22_01872 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) DXY22_01873 ENOG4105D06 uba thif-type nad fad binding protein DXY22_01874 ENOG4105DWF phosphomethylpyrimidine kinase DXY22_01875 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH DXY22_01876 ENOG4107A88 DXY22_01886 ENOG4105ENA helicase DXY22_01889 ENOG4108ZMI UPF0477 protein DXY22_01894 ENOG4105C28 cystathionine DXY22_01895 ENOG4105C28 cystathionine DXY22_01896 ENOG4105D9U N-acetyltransferase DXY22_01897 ENOG4105JHY Membrane DXY22_01900 ENOG41068SY DXY22_01903 ENOG4107KNS DXY22_01907 ENOG4108PSK reductase DXY22_01910 ENOG4105DM4 PTS System DXY22_01911 ENOG4105DG6 mannose-6-phosphate isomerase DXY22_01912 ENOG4105G7B Protein of unknown function (DUF2992) DXY22_01913 ENOG4105VMI -acetyltransferase DXY22_01915 ENOG4108Z66 YbaK ebsC protein DXY22_01918 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) DXY22_01920 ENOG4108ZJ4 polysaccharide deacetylase DXY22_01921 ENOG4107CUJ Protein of unknown function (DUF2690) DXY22_01926 ENOG4108IEG Formate dehydrogenase Alpha subunit DXY22_01931 ENOG4106A3M Cytochrome p-450 DXY22_01932 ENOG41087PP glycosyltransferase MGT family DXY22_01934 ENOG4105EXQ uroporphyrinogen iii synthase hem4 DXY22_01935 ENOG4105C4B ABC transporter, permease DXY22_01936 ENOG4108IXI (ABC) transporter DXY22_01938 ENOG4105Q95 Cupin 2, conserved barrel domain protein DXY22_01941 ENOG4105D2H Uronic isomerase DXY22_01942 ENOG4105CT4 transporter DXY22_01943 ENOG4105DG4 malate L-lactate dehydrogenase DXY22_01944 ENOG4105CPQ Dehydrogenase DXY22_01945 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) DXY22_01946 ENOG4105DMW Dehydrogenase reductase DXY22_01947 ENOG4108I5G Major Facilitator superfamily DXY22_01948 ENOG4107KJX Transcriptional regulator DXY22_01949 ENOG4107QZW Altronate oxidoreductase DXY22_01950 ENOG4105CTX dehydratase DXY22_01951 ENOG4107TSN permease DXY22_01953 ENOG4105JD4 ATPase yjob DXY22_01956 ENOG41068K0 YCII-related domain DXY22_01957 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase DXY22_01958 ENOG4105KWG Pfam:DUF1696 DXY22_01959 ENOG4105K7W phage-related replication protein DXY22_01960 ENOG4105WEF catalase DXY22_01961 ENOG410635T phage-like element pbsx protein DXY22_01970 ENOG4108TFU terminase (Small subunit) DXY22_01971 ENOG4105IG6 Phage terminase, large subunit DXY22_01972 ENOG4108MDF Phage Portal Protein DXY22_01977 ENOG41060SN DXY22_01979 ENOG4105PQS phage protein DXY22_01980 ENOG4105FR7 XkdM protein, phage-like element PBSX DXY22_01981 ENOG4105MTC XkdN-like protein DXY22_01982 ENOG4108FKH Transglycosylase SLT domain DXY22_01982 ENOG4108FKH Transglycosylase SLT domain DXY22_01983 ENOG4108WZM domain protein DXY22_01984 ENOG4105X7F DXY22_01986 ENOG4105MFU Protein of unknown function (DUF2634) DXY22_01987 ENOG41066EA baseplate J family protein DXY22_01988 ENOG410906S phage-like element pbsx protein xkdt DXY22_01990 ENOG41068G1 DXY22_01996 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DXY22_01999 ENOG4105CJ3 phosphate transporter DXY22_02000 ENOG4107GRR phosphate transport regulator DXY22_02001 ENOG4107R7I amino acid DXY22_02004 ENOG4105EDW glycosyl transferase, family 39 DXY22_02005 ENOG4105CKK Glycosyl transferase, family 2 DXY22_02007 ENOG4105C0H protease DXY22_02009 ENOG4108ME1 Peptidase M55 D-aminopeptidase DXY22_02010 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component DXY22_02011 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component DXY22_02012 ENOG4105C3U ABC transporter DXY22_02015 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A DXY22_02016 ENOG4105DTQ mandelate racemase muconate lactonizing DXY22_02017 ENOG4107SN7 NLP P60 protein DXY22_02018 ENOG4108JQ7 (ABC) transporter DXY22_02019 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) DXY22_02020 ENOG4107TUM Amidinotransferase DXY22_02021 ENOG4108S4H thioesterase Superfamily protein DXY22_02022 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) DXY22_02026 ENOG4108428 Inherit from COG: -acetyltransferase DXY22_02028 ENOG41080TC multidrug resistance protein DXY22_02029 ENOG4105CIY formyltetrahydrofolate deformylase DXY22_02030 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) DXY22_02033 ENOG4105K56 Transcriptional regulator DXY22_02034 ENOG4108ZHJ Organic hydroperoxide resistance protein DXY22_02035 ENOG4107Y2X deaminase DXY22_02036 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) DXY22_02037 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin DXY22_02039 ENOG4108W7F transporter, permease DXY22_02040 ENOG4108JJB ABC transporter DXY22_02041 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein DXY22_02042 ENOG4108X43 YKOF domain protein DXY22_02043 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DXY22_02044 ENOG41062D9 Histidine kinase DXY22_02046 ENOG4106849 propeptide, pepSY amd peptidase M4 DXY22_02049 ENOG4105CJW magnesium transporter DXY22_02050 ENOG4105V75 Transcriptional regulator DXY22_02059 ENOG4105DQE DNA ligase DXY22_02060 ENOG4105FDF Could be involved in DNA repair (By similarity) DXY22_02061 ENOG4105BZU Histidine kinase DXY22_02062 ENOG4107T5V SNARE associated Golgi DXY22_02063 ENOG4107TS3 membrane protein, TerC DXY22_02064 ENOG4108WZW RNA polymerase sigma DXY22_02066 ENOG410681C small acid-soluble spore protein DXY22_02068 ENOG4105D0M Protease HtpX homolog DXY22_02072 ENOG4108TGC Acyltransferase DXY22_02073 ENOG4105BZU Histidine kinase DXY22_02074 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) DXY22_02076 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) DXY22_02077 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) DXY22_02078 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase DXY22_02080 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit DXY22_02081 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) DXY22_02082 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) DXY22_02083 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) DXY22_02087 ENOG4105BZU Histidine kinase DXY22_02088 ENOG41090MY MarR family Transcriptional regulator DXY22_02089 ENOG4105ER2 Ompa motb domain protein DXY22_02090 ENOG4105E14 MotA TolQ exbB proton channel DXY22_02092 ENOG4108K88 Membrane DXY22_02093 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) DXY22_02094 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase DXY22_02095 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) DXY22_02096 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) DXY22_02098 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr DXY22_02099 ENOG4105FEA Spore maturation protein DXY22_02105 ENOG4105F0V Cell wall hydrolase DXY22_02108 ENOG4105C59 p-type ATPase DXY22_02110 ENOG4105DC7 peptidase M24 DXY22_02113 ENOG4105CID antiterminator DXY22_02115 ENOG4105KRI phosphocarrier protein (HPr DXY22_02116 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) DXY22_02118 ENOG4105F6S Spore photoproduct lyase DXY22_02120 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer DXY22_02121 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase DXY22_02122 ENOG4105K4I Scp-like extracellular DXY22_02124 ENOG4105BZU Histidine kinase DXY22_02125 ENOG4105CHM Aminotransferase DXY22_02127 ENOG4107R88 Chemotaxis protein (CheV) DXY22_02128 ENOG4105UIN DXY22_02130 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein DXY22_02132 ENOG4105K6S Short-chain dehydrogenase reductase Sdr DXY22_02133 ENOG4105ESF Peptidoglycan binding domain protein DXY22_02135 ENOG4105EPM Diguanylate phosphodiesterase DXY22_02136 ENOG4107IN1 Protein of unknown function (DUF1797) DXY22_02137 ENOG4108XRC Protein of unknown function (DUF458) DXY22_02143 ENOG4105NQC Flavodoxin DXY22_02145 ENOG4105CH2 amidohydrolase DXY22_02147 ENOG4105D8X mechanosensitive ion channel DXY22_02148 ENOG4105D3R alkyl hydroperoxide reductase DXY22_02149 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DXY22_02152 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) DXY22_02153 ENOG4105D06 uba thif-type nad fad binding protein DXY22_02154 ENOG4105CVM Molybdenum cofactor synthesis domain protein DXY22_02155 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein DXY22_02156 ENOG4108ZAF Molybdopterin DXY22_02157 ENOG41067WU Molybdopterin converting factor (Subunit 1) DXY22_02158 ENOG4105BZ1 (ABC) transporter DXY22_02159 ENOG4105BZ1 (ABC) transporter DXY22_02161 ENOG4107X8C Efflux transporter RND family MFP subunit DXY22_02162 ENOG4105C19 ABC transporter DXY22_02163 ENOG4107RBB ABC transporter, permease DXY22_02164 ENOG4105E98 transcriptional regulator DeoR family DXY22_02165 ENOG4105DE4 1-phosphofructokinase DXY22_02166 ENOG4105DM4 PTS System DXY22_02167 ENOG4105C3F Signal peptidase i DXY22_02169 ENOG4105C5H ABC transporter DXY22_02170 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) DXY22_02175 ENOG4105BZU Histidine kinase DXY22_02177 ENOG4107ZYR domain protein DXY22_02179 ENOG4105CN5 Metallo-Beta-Lactamase DXY22_02181 ENOG4108X4Q Hydrolase DXY22_02182 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DXY22_02186 ENOG4105CPP Dehydrogenase, E1 component DXY22_02187 ENOG4105C7S Dehydrogenase DXY22_02188 ENOG4107QN2 dihydrolipoyl dehydrogenase DXY22_02190 ENOG4105CXN decarboxylase DXY22_02191 ENOG4105WBI UPF0223 protein DXY22_02194 ENOG4105ECY inositol monophosphatase DXY22_02196 ENOG4105JQZ Methyltransferase DXY22_02204 ENOG4105CI3 gtp-binding protein typa DXY22_02205 ENOG4105QA2 DXY22_02208 ENOG4108IAB Phoh family DXY22_02210 ENOG4105CSV Glutaminase DXY22_02211 ENOG4105ZPI UPF0358 protein DXY22_02212 ENOG4105CNI cell division protein FtsW DXY22_02213 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) DXY22_02215 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) DXY22_02217 ENOG4105BZ9 Cytochrome C oxidase, subunit I DXY22_02218 ENOG4105CCU oxidase (Subunit III) DXY22_02219 ENOG41064X9 cytochrome C oxidase subunit IV DXY22_02222 ENOG41080XQ Signal transduction protein with cbs domains DXY22_02223 ENOG4106UY4 Inherit from COG: Scp-like extracellular DXY22_02227 ENOG4105WUC UPF0298 protein DXY22_02228 ENOG4106H78 methyltransferase DXY22_02229 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) DXY22_02230 ENOG4105H20 Sporulation integral membrane protein YlbJ DXY22_02231 ENOG4105D78 K07001 NTE family protein DXY22_02232 ENOG41063PX domain protein DXY22_02233 ENOG4105CDE UPF0348 protein DXY22_02235 ENOG4105KNH Nucleic acid-binding protein DXY22_02241 ENOG4108V6E Cell division protein mraZ DXY22_02242 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) DXY22_02244 ENOG4105CJN penicillin-binding protein DXY22_02245 ENOG4105CJN penicillin-binding protein DXY22_02246 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) DXY22_02247 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) DXY22_02248 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) DXY22_02249 ENOG4105CNI cell division protein FtsW DXY22_02250 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) DXY22_02251 ENOG4105D4A Cell wall formation (By similarity) DXY22_02252 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) DXY22_02253 ENOG4108R2U division initiation protein DXY22_02255 ENOG4105K67 small basic protein DXY22_02256 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) DXY22_02257 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) DXY22_02259 ENOG4105FFI sigma-e processing peptidase spoiiga DXY22_02260 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DXY22_02262 ENOG4105DKW ABC transporter DXY22_02264 ENOG4105WR5 sporulation protein, YlmC YmxH family DXY22_02265 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase DXY22_02266 ENOG4105DFA alanine racemase domain protein DXY22_02267 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) DXY22_02268 ENOG41067XK integral membrane protein DXY22_02269 ENOG4105DBK s4 domain protein DXY22_02271 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) DXY22_02273 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) DXY22_02274 ENOG4105C34 Pseudouridine synthase DXY22_02275 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) DXY22_02277 ENOG4105CXT aspartate transcarbamylase DXY22_02279 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain DXY22_02280 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain DXY22_02281 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) DXY22_02282 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) DXY22_02283 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) DXY22_02284 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) DXY22_02286 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) DXY22_02288 ENOG4107S4M Sulfate adenylate transferase DXY22_02289 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) DXY22_02290 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) DXY22_02291 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein DXY22_02292 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein DXY22_02295 ENOG4105DSJ YicC domain protein DXY22_02296 ENOG4105KC4 UPF0296 protein DXY22_02297 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) DXY22_02299 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase DXY22_02300 ENOG4105C25 Primosomal protein n' DXY22_02301 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) DXY22_02302 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) DXY22_02303 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B DXY22_02304 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs DXY22_02305 ENOG4108ZF3 Phosphatase DXY22_02306 ENOG4105D9P serine threonine protein kinase DXY22_02307 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) DXY22_02308 ENOG4105DJV ribulose-phosphate 3-epimerase DXY22_02309 ENOG4105FJ0 thiamine DXY22_02310 ENOG4105VB9 50S ribosomal protein l28 DXY22_02311 ENOG4108ZAA Alkaline-shock protein DXY22_02312 ENOG4105DP4 dak2 domain fusion protein ylov DXY22_02314 ENOG4105EJQ L-serine dehydratase DXY22_02315 ENOG4105CB5 ATP-dependent DNA helicase recG DXY22_02316 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) DXY22_02318 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DXY22_02319 ENOG4105CHR reductase DXY22_02321 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) DXY22_02322 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) DXY22_02323 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) DXY22_02325 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) DXY22_02327 ENOG4105K5M 30s ribosomal protein S16 DXY22_02328 ENOG4108BW8 UPF0109 protein DXY22_02330 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) DXY22_02331 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) DXY22_02332 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) DXY22_02333 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) DXY22_02334 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DXY22_02336 ENOG4105VM1 flagellar DXY22_02337 ENOG4105CMV Succinyl-CoA synthetase subunit beta DXY22_02338 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha DXY22_02339 ENOG4105C79 DNA protecting protein DprA DXY22_02340 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) DXY22_02341 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) DXY22_02342 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DXY22_02343 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) DXY22_02344 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) DXY22_02346 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) DXY22_02347 ENOG4108ZC9 flagellar basal-body rod protein flgc DXY22_02348 ENOG4105VQ0 flagellar hook-basal body complex protein fliE DXY22_02349 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) DXY22_02350 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DXY22_02353 ENOG4106YF4 Flagellar biosynthesis chaperone DXY22_02355 ENOG410696Y Flagellar hook-length control protein DXY22_02356 ENOG410822I Flagellar hook capping protein DXY22_02357 ENOG4108JQA flagellar DXY22_02359 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) DXY22_02360 ENOG4105DD5 Flagellar motor switch protein DXY22_02361 ENOG4107YTP response regulator receiver protein DXY22_02363 ENOG4105CN7 Flagellar biosynthetic protein FliP DXY22_02364 ENOG4105VS8 Flagellar biosynthetic protein fliq DXY22_02365 ENOG4105D19 Role in flagellar biosynthesis (By similarity) DXY22_02366 ENOG4105D00 flagellar biosynthetic protein flhB DXY22_02367 ENOG4105D7B Flagellar biosynthesis protein flha DXY22_02368 ENOG4105FZW flagellar biosynthesis regulator FlhF DXY22_02370 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) DXY22_02371 ENOG4105CBS Chea signal transduction histidine kinase DXY22_02372 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis DXY22_02375 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DXY22_02377 ENOG4105CE9 30S ribosomal protein S2 DXY22_02378 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) DXY22_02380 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) DXY22_02381 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) DXY22_02382 ENOG4105KNE Phosphatidate cytidylyltransferase DXY22_02384 ENOG4105DZP Membrane-associated zinc metalloprotease DXY22_02385 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) DXY22_02386 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) DXY22_02387 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) DXY22_02388 ENOG4105CHV Transcription elongation factor NusA DXY22_02389 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination DXY22_02390 ENOG4105VHM ribosomal protein DXY22_02391 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) DXY22_02392 ENOG4105W7A Protein of unknown function (DUF503) DXY22_02393 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) DXY22_02394 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) DXY22_02395 ENOG4105DTN riboflavin biosynthesis protein ribF DXY22_02396 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) DXY22_02397 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) DXY22_02399 ENOG4105C1V Peptidase, M16 DXY22_02401 ENOG4105E35 Dipicolinate synthase subunit A DXY22_02402 ENOG4108S0H Dipicolinic acid synthetase, b subunit DXY22_02403 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) DXY22_02405 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) DXY22_02407 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit DXY22_02409 ENOG4105CNU cell division protein FtsK DXY22_02410 ENOG4105FDP GntR family transcriptional regulator DXY22_02414 ENOG4108RKS Short-chain dehydrogenase reductase Sdr DXY22_02415 ENOG4105XZV Protein of unknown function (DUF3243) DXY22_02418 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase DXY22_02419 ENOG4105CEV competence damage-inducible protein DXY22_02421 ENOG4108A04 Beta-lactamase DXY22_02422 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) DXY22_02423 ENOG4105D48 metallophosphoesterase DXY22_02424 ENOG4105MCT stage V sporulation protein S DXY22_02426 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DXY22_02427 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DXY22_02430 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) DXY22_02431 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) DXY22_02433 ENOG4105IIP Membrane DXY22_02434 ENOG4105W1N transcriptional regulator DXY22_02435 ENOG4108151 Beta-lactamase domain protein DXY22_02436 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase DXY22_02439 ENOG4107QKG PfaD family DXY22_02440 ENOG41062T2 Acyl carrier protein DXY22_02441 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase DXY22_02442 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase DXY22_02443 ENOG4108MGH Enoyl-CoA hydratase DXY22_02444 ENOG4108KQ6 Enoyl-CoA hydratase DXY22_02445 ENOG4105C0W non-ribosomal peptide synthetase DXY22_02446 ENOG4107SQU synthase DXY22_02448 ENOG4105C0W non-ribosomal peptide synthetase DXY22_02450 ENOG4106A3M Cytochrome p-450 DXY22_02453 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin DXY22_02455 ENOG4105K7W phage-related replication protein DXY22_02456 ENOG4108X3M OsmC Ohr family protein DXY22_02457 ENOG410814C multidrug resistance protein DXY22_02461 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) DXY22_02462 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) DXY22_02465 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) DXY22_02466 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DXY22_02467 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) DXY22_02468 ENOG4105U6W MutT NUDIX family protein DXY22_02469 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DXY22_02470 ENOG4106F1P AAA ATPase, central domain protein DXY22_02471 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) DXY22_02472 ENOG4105CXI aluminum resistance protein DXY22_02473 ENOG4105KV4 Transcriptional regulator DXY22_02474 ENOG4105C5F glutamine synthetase DXY22_02475 ENOG41079P0 DXY22_02479 ENOG4107AUC DXY22_02483 ENOG4107NTZ DXY22_02487 ENOG410907G DXY22_02488 ENOG4105CT4 transporter DXY22_02489 ENOG4105DSG hydrolase family 43 DXY22_02490 ENOG4105E2R ROK family DXY22_02491 ENOG4105C93 Xylose Isomerase DXY22_02492 ENOG4105CMG Carbohydrate kinase DXY22_02493 ENOG4107Y9E nuclease DXY22_02494 ENOG4105C54 Major Facilitator superfamily DXY22_02495 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) DXY22_02497 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) DXY22_02512 ENOG4108Q8B Spore germination protein DXY22_02513 ENOG4108NHD germination protein DXY22_02516 ENOG4105FVX DXY22_02518 ENOG4105K7W phage-related replication protein DXY22_02520 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) DXY22_02521 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) DXY22_02523 ENOG4108SVB resolvase DXY22_02524 ENOG4105VPS UPF0291 protein DXY22_02525 ENOG4105CV1 Transketolase (EC 2.2.1.1) DXY22_02529 ENOG4107QIV Cytochrome c biogenesis protein DXY22_02534 ENOG4107DZX Small, acid-soluble spore protein P DXY22_02536 ENOG4108I0Z Aconitate hydratase DXY22_02537 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen DXY22_02540 ENOG41067CD Small, acid-soluble spore protein Tlp DXY22_02542 ENOG4105MI2 DXY22_02543 ENOG4105W8X HesB YadR YfhF-family protein DXY22_02544 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) DXY22_02545 ENOG4105K4P CoA-binding domain protein DXY22_02546 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) DXY22_02551 ENOG4107QWR cellulase (EC 3.2.1.4) DXY22_02553 ENOG4108MYR Secreted protein DXY22_02554 ENOG4107SYN Glycosyl hydrolases family 43 DXY22_02556 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase DXY22_02557 ENOG4107T5V SNARE associated Golgi DXY22_02559 ENOG4107QX3 carboxylase DXY22_02560 ENOG4105E39 Enoyl-CoA hydratase DXY22_02561 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase DXY22_02562 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit DXY22_02563 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DXY22_02564 ENOG4105CEY Amp-dependent synthetase and ligase DXY22_02565 ENOG4105C1G acyl-Coa dehydrogenase DXY22_02566 ENOG4105F32 YngK protein DXY22_02567 ENOG4106U2H Protein of unknown function (DUF1360) DXY22_02569 ENOG4105CEY Amp-dependent synthetase and ligase DXY22_02570 ENOG4105C0W non-ribosomal peptide synthetase DXY22_02572 ENOG4105C0W non-ribosomal peptide synthetase DXY22_02573 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family DXY22_02574 ENOG4108N2V aldose 1-epimerase DXY22_02575 ENOG4107QJQ Mate efflux family protein DXY22_02580 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) DXY22_02581 ENOG4105SKE transcriptional Regulator LysR family DXY22_02582 ENOG4105CB2 alcohol dehydrogenase DXY22_02583 ENOG4105BZ8 glutamate synthase DXY22_02584 ENOG4105CBC glutamate synthase DXY22_02585 ENOG4105C5Q Transcriptional regulator DXY22_02586 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) DXY22_02587 ENOG4105II7 pyrroline-5-carboxylate reductase DXY22_02591 ENOG4108UB7 DXY22_02592 ENOG41068WN DXY22_02595 ENOG4105CJ1 ABC, transporter DXY22_02597 ENOG4105IE8 Alpha-ketoglutarate permease DXY22_02598 ENOG4107U6E carbohydrate kinase FGGY DXY22_02599 ENOG4108M3J Dehydrogenase DXY22_02600 ENOG4108J2R molybdopterin oxidoreductase DXY22_02605 ENOG4105EC8 Methyl-accepting chemotaxis DXY22_02607 ENOG4108YQE rare lipoprotein a DXY22_02608 ENOG4105XPP Protein of unknown function (DUF1275) DXY22_02609 ENOG4108NR7 pectate lyase DXY22_02610 ENOG4108RAV Conserved protein DXY22_02613 ENOG4105F0F Oxalate decarboxylase DXY22_02615 ENOG4105EPI acetyltransferase, (GNAT) family DXY22_02619 ENOG41073R8 VanW family DXY22_02621 ENOG4105VMP Transcriptional regulator DXY22_02622 ENOG4105NX3 Membrane DXY22_02624 ENOG4108Q5Y Membrane DXY22_02626 ENOG4108V4B ThiJ pfpI DXY22_02627 ENOG4108J4B Beta-lactamase DXY22_02630 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) DXY22_02631 ENOG4107T94 Endo-14-beta-xylanase DXY22_02633 ENOG4105YB8 TM2 domain containing protein DXY22_02634 ENOG4108IMY Transcriptional regulator DXY22_02637 ENOG4108RAV Conserved protein DXY22_02638 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DXY22_02639 ENOG4105D3P Mannan endo-1,4-beta-mannosidase DXY22_02640 ENOG4105ETE Transcriptional regulator (LacI family DXY22_02641 ENOG4105CS2 ec 3.2.1.21 DXY22_02644 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component DXY22_02645 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component DXY22_02647 ENOG41066F8 ROK family DXY22_02648 ENOG4106ANW SMI1_KNR4 DXY22_02649 ENOG4106BHF DXY22_02652 ENOG4108Z7R Chaperone CsaA DXY22_02653 ENOG4105FTV AraC Family Transcriptional Regulator DXY22_02654 ENOG4108HJF gCN5-related N-acetyltransferase DXY22_02656 ENOG4108W8B Beta-lactamase domain protein DXY22_02658 ENOG4105D29 Helix-turn-helix type 11 domain protein DXY22_02660 ENOG4105KTU Transcriptional regulator, arsr family DXY22_02662 ENOG4108SJC Membrane DXY22_02666 ENOG4105ECK Fatty Acid Desaturase DXY22_02667 ENOG4108ZGX Histidine kinase DXY22_02668 ENOG4108S01 response regulator DXY22_02669 ENOG41069ER domain protein DXY22_02670 ENOG4105C9U ATP-dependent DNA helicase RecQ DXY22_02672 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DXY22_02673 ENOG4105SCY DNAK suppressor DXY22_02681 ENOG4105C26 Dehydrogenase DXY22_02682 ENOG4105EWU Squalene--hopene cyclase DXY22_02683 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DXY22_02684 ENOG4105C8J )-transporter DXY22_02685 ENOG4105C09 Bile acid DXY22_02686 ENOG4105C7S Dehydrogenase DXY22_02688 ENOG4107T89 von Willebrand factor, type A DXY22_02689 ENOG4105GMT ATPase associated with various cellular activities aaa_5 DXY22_02691 ENOG4105K4H Nlp p60 protein DXY22_02692 ENOG41087PP glycosyltransferase MGT family DXY22_02695 ENOG4107QMU Mate efflux family protein DXY22_02696 ENOG4106SCS STAS domain DXY22_02700 ENOG4105FR1 rard protein DXY22_02703 ENOG4105C6Z Gluconate DXY22_02704 ENOG41090U3 tautomerase DXY22_02707 ENOG4105FBA Phospholipase Carboxylesterase DXY22_02710 ENOG4105E1V na solute symporter DXY22_02714 ENOG4108VXD carboxy-peptidase DXY22_02715 ENOG4105D3A purine nucleoside phosphorylase DeoD-type DXY22_02717 ENOG4106Z5R DXY22_02718 ENOG410841Q phosphoesterase PA-phosphatase related protein DXY22_02724 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein DXY22_02725 ENOG4108TSC N-acetyltransferase DXY22_02726 ENOG4107S4Y M20 DapE family protein YgeY DXY22_02729 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DXY22_02736 ENOG4107T32 3-phytase (EC 3.1.3.8) DXY22_02737 ENOG4105C5E polysaccharide biosynthesis protein DXY22_02738 ENOG4105E0X reductase DXY22_02739 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) DXY22_02743 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) DXY22_02744 ENOG41090WU lipolytic protein G-D-S-L family DXY22_02745 ENOG4108KF3 Electron transport protein SCO1 SenC DXY22_02747 ENOG4105C7B Threonine dehydratase DXY22_02749 ENOG4108UT2 hemolysin iii DXY22_02751 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) DXY22_02752 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) DXY22_02755 ENOG4107YX5 Pfam:DUF548 DXY22_02756 ENOG4108Y6J UPF0403 protein DXY22_02757 ENOG4105C01 Dihydroxy-acid dehydratase DXY22_02760 ENOG4108V06 Glutathione peroxidase DXY22_02761 ENOG4105CVG Homoserine O-transsuccinylase DXY22_02769 ENOG41081VK Ribonuclease DXY22_02774 ENOG410890F Dynamin family DXY22_02776 ENOG41065KQ synthase DXY22_02777 ENOG4105C2W permease DXY22_02778 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) DXY22_02779 ENOG4105CTD carboxy-peptidase DXY22_02780 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) DXY22_02781 ENOG4108UHU Aldolase DXY22_02782 ENOG4105D7K pfkb domain protein DXY22_02783 ENOG4108M60 Transcriptional regulator DXY22_02785 ENOG4105CHR reductase DXY22_02786 ENOG4105DVT helicase DXY22_02789 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) DXY22_02791 ENOG4108UKS UPF0398 protein DXY22_02792 ENOG4107X2U Inherit from COG: Exonuclease-like protein DXY22_02793 ENOG4108I5C dEAD DEAH box helicase DXY22_02802 ENOG4105BZ4 penicillin-binding protein DXY22_02804 ENOG4105CSM endonuclease III DXY22_02806 ENOG4105C5S asparaginyl-tRNA synthetase DXY22_02807 ENOG4105CHM Aminotransferase DXY22_02809 ENOG4105YAC DXY22_02810 ENOG4105DVT helicase DXY22_02811 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) DXY22_02812 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) DXY22_02813 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) DXY22_02814 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase DXY22_02815 ENOG4105DJ0 Poly(A) Polymerase DXY22_02816 ENOG4105CPK Glycosyl transferase (Group 1 DXY22_02817 ENOG4105FJR Lmbe family DXY22_02818 ENOG4108Z5K methylglyoxal synthase DXY22_02819 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) DXY22_02820 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase DXY22_02821 ENOG4108JYZ YitT family DXY22_02825 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) DXY22_02829 ENOG41068YB TPR repeat-containing protein DXY22_02830 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase DXY22_02832 ENOG4105CIH Imidazole acetol-phosphate transaminase DXY22_02834 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) DXY22_02835 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase DXY22_02837 ENOG4108I0Q anthranilate phosphoribosyltransferase DXY22_02838 ENOG4105CRQ synthase (Component I) DXY22_02839 ENOG4105KHN chorismate mutase DXY22_02840 ENOG4105D49 3-dehydroquinate synthase DXY22_02841 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase DXY22_02842 ENOG4105BZU Histidine kinase DXY22_02843 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) DXY22_02844 ENOG4105EAH synthase DXY22_02845 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) DXY22_02846 ENOG4105XXQ heptaprenyl diphosphate synthase component I DXY22_02848 ENOG4105EUJ GTP cyclohydrolase i DXY22_02849 ENOG4105K70 DNA-binding protein DXY22_02850 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) DXY22_02853 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase DXY22_02854 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) DXY22_02855 ENOG41065D1 DXY22_02856 ENOG4105S2F DXY22_02859 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) DXY22_02860 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) DXY22_02861 ENOG4105CAT Cytidine monophosphate kinase DXY22_02864 ENOG4105MSI germination protein ypeb DXY22_02866 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) DXY22_02867 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase DXY22_02870 ENOG4107RGJ metallophosphoesterase DXY22_02873 ENOG4105I7S Abortive infection protein DXY22_02874 ENOG4105C9U ATP-dependent DNA helicase RecQ DXY22_02875 ENOG4105T7X DXY22_02877 ENOG4108SAX Membrane DXY22_02878 ENOG4108JQ1 Dehydrogenase DXY22_02879 ENOG4105FF2 Type I DHQase DXY22_02882 ENOG4105BZU Histidine kinase DXY22_02883 ENOG4105CK6 Two component transcriptional regulator (Winged helix family DXY22_02884 ENOG4105CRE cytochrome C DXY22_02885 ENOG4107TWT Cytochrome c biogenesis protein DXY22_02887 ENOG4105FE9 pseudouridine synthase DXY22_02889 ENOG4108JIC nucleoside recognition domain protein DXY22_02890 ENOG4105DZ1 carboxypeptidase DXY22_02892 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) DXY22_02893 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) DXY22_02896 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) DXY22_02897 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) DXY22_02898 ENOG4108R6K riboflavin synthase, subunit alpha DXY22_02899 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) DXY22_02901 ENOG4105C3F Signal peptidase i DXY22_02902 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) DXY22_02905 ENOG4107ZE5 PPIases accelerate the folding of proteins DXY22_02906 ENOG4105PTM secreted protein DXY22_02907 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) DXY22_02909 ENOG4105G6R Stage v sporulation protein ae DXY22_02911 ENOG4105CZ3 stage V sporulation protein ad DXY22_02912 ENOG41090VF Stage v sporulation protein ac DXY22_02915 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DXY22_02916 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) DXY22_02917 ENOG41082AN stage II sporulation protein DXY22_02918 ENOG4105DZ1 carboxypeptidase DXY22_02919 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) DXY22_02920 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) DXY22_02921 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) DXY22_02923 ENOG4105I3K Ferric uptake regulator, Fur family DXY22_02924 ENOG4105MZ9 stage II sporulation protein m DXY22_02927 ENOG4105DFD Na H antiporter DXY22_02928 ENOG4108IJ0 Aspartate ammonia-lyase DXY22_02929 ENOG4105HDK L-asparaginase DXY22_02930 ENOG4108IMY Transcriptional regulator DXY22_02932 ENOG4108YZ4 nudix hydrolase DXY22_02934 ENOG4105CPC Aldo Keto reductase DXY22_02938 ENOG4106HZJ DXY22_02939 ENOG4105RHY Pfam:UPF0157 DXY22_02940 ENOG4105KAC Antibiotic biosynthesis monooxygenase DXY22_02941 ENOG4108XET gCN5-related N-acetyltransferase DXY22_02943 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DXY22_02945 ENOG4105E5W Transporter DXY22_02947 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase DXY22_02950 ENOG4108IXY short-chain dehydrogenase reductase DXY22_02951 ENOG41069FQ Metallo-beta-lactamase superfamily DXY22_02952 ENOG4105II7 pyrroline-5-carboxylate reductase DXY22_02954 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DXY22_02956 ENOG410861F 50S ribosomal protein L33 DXY22_02957 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) DXY22_02958 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase DXY22_02959 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) DXY22_02960 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) DXY22_02962 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) DXY22_02963 ENOG4108NA0 Uncharacterized conserved protein (COG2071) DXY22_02964 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) DXY22_02965 ENOG4108HNZ carboxyl transferase DXY22_02966 ENOG4108ZVT methylmalonyl-coA epimerase DXY22_02968 ENOG4108VZI ErfK ybiS ycfS ynhG family protein DXY22_02969 ENOG4108QEG Membrane DXY22_02970 ENOG4105CDA abc transporter atp-binding protein DXY22_02971 ENOG4105E5Q amino acid AbC transporter DXY22_02972 ENOG4108HW3 (ABC) transporter DXY22_02973 ENOG4108Y6J UPF0403 protein DXY22_02974 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) DXY22_02977 ENOG4105C7S Dehydrogenase DXY22_02978 ENOG4105CPP Dehydrogenase, E1 component DXY22_02981 ENOG4105CKM Branched-chain carboxylic acid kinase DXY22_02982 ENOG4107RDP Dehydrogenase DXY22_02984 ENOG4108JUB Transcriptional regulator DXY22_02985 ENOG4106CCJ Protein of unknown function (DUF2627) DXY22_02986 ENOG4105CR4 methylisocitrate lyase DXY22_02987 ENOG4105DXD 2-methylcitrate dehydratase DXY22_02989 ENOG4105C1G acyl-Coa dehydrogenase DXY22_02990 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase DXY22_02992 ENOG4108QXE glycerophosphoryl diester phosphodiesterase DXY22_02993 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DXY22_02995 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase DXY22_02997 ENOG4107QQR Sporulation DXY22_02998 ENOG4105S1Z Stage IV sporulation protein B DXY22_02999 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) DXY22_03000 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) DXY22_03001 ENOG4105DX0 Hemolysin A DXY22_03003 ENOG4105CTB Polyprenyl synthetase DXY22_03004 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DXY22_03005 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) DXY22_03006 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) DXY22_03007 ENOG4105M7K Involved in the transcription termination process (By similarity) DXY22_03008 ENOG4108ZSR alkaline shock protein DXY22_03009 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase DXY22_03013 ENOG410644B Stage III sporulation protein af DXY22_03015 ENOG4105KQ4 Stage iii sporulation protein ad DXY22_03016 ENOG4108CQH stage III sporulation protein AC DXY22_03017 ENOG4105KR5 Stage iii sporulation protein DXY22_03018 ENOG4105CD2 stage iii sporulation protein aa DXY22_03020 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) DXY22_03021 ENOG4105DC7 peptidase M24 DXY22_03022 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) DXY22_03024 ENOG4105CBJ Metal-dependent enzyme DXY22_03027 ENOG4105KST dependent repressor DXY22_03028 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) DXY22_03029 ENOG4105WZW rhodanese family DXY22_03030 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor DXY22_03031 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor DXY22_03032 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) DXY22_03033 ENOG4105C0D helicase DXY22_03036 ENOG4108IMY Transcriptional regulator DXY22_03038 ENOG4105VFR signal peptidase DXY22_03050 ENOG41080XP Cbs domain DXY22_03052 ENOG4105C37 (CBS) domain DXY22_03057 ENOG4105C5X domain protein DXY22_03062 ENOG4105E0M Sulfatase DXY22_03065 ENOG4107ZXI Rhomboid family DXY22_03067 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase DXY22_03072 ENOG41068DG YceG-like family DXY22_03073 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DXY22_03074 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) DXY22_03075 ENOG4105E2Z phosphate ABC transporter (Permease DXY22_03076 ENOG4105C8U phosphate abc transporter DXY22_03077 ENOG4105CVA phosphate DXY22_03078 ENOG4107RF6 penicillin-binding protein DXY22_03080 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) DXY22_03081 ENOG4105SXS Protein of unknown function (DUF456) DXY22_03085 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) DXY22_03086 ENOG41063Y9 DXY22_03087 ENOG4108U5J '-nucleotidase DXY22_03088 ENOG4105N80 Ferric uptake regulator, Fur family DXY22_03089 ENOG4108JYZ YitT family DXY22_03090 ENOG41069ZM Protein of unknown function (DUF2624) DXY22_03091 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) DXY22_03094 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) DXY22_03095 ENOG4105EGD dinuclear metal center protein, YbgI family DXY22_03098 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DXY22_03099 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) DXY22_03100 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 DXY22_03101 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) DXY22_03103 ENOG4105C38 Glycyl-tRNA synthetase beta subunit DXY22_03104 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit DXY22_03105 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) DXY22_03107 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) DXY22_03108 ENOG4105KG3 cytidine deaminase DXY22_03109 ENOG4107YR5 Diacylglycerol kinase DXY22_03110 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) DXY22_03111 ENOG4105CTJ Metal Dependent Phosphohydrolase DXY22_03113 ENOG4105C9A Phoh family DXY22_03114 ENOG4105EI1 sporulation protein yqfd DXY22_03115 ENOG41068P3 sporulation protein YqfC DXY22_03117 ENOG4105DI5 UPF0365 protein DXY22_03118 ENOG4105F7J membrane-bound serine protease DXY22_03119 ENOG4105KTH gatB Yqey DXY22_03122 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) DXY22_03123 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) DXY22_03124 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) DXY22_03126 ENOG4105CFG Acts as a chaperone (By similarity) DXY22_03127 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ DXY22_03128 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) DXY22_03129 ENOG4105CSA Coproporphyrinogen iii oxidase DXY22_03130 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) DXY22_03132 ENOG4108ZRV stage ii sporulation protein p DXY22_03133 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) DXY22_03134 ENOG41082YS Binds directly to 16S ribosomal RNA DXY22_03135 ENOG4105TQK DNA polymerase iii, delta' subunit DXY22_03137 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 DXY22_03138 ENOG4108UK2 deaminase DXY22_03139 ENOG4105KQC Competence protein DXY22_03141 ENOG4108D32 Methyltransferase DXY22_03143 ENOG4108WF2 Metal Dependent Phosphohydrolase DXY22_03144 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) DXY22_03145 ENOG410812S Rna-binding protein DXY22_03146 ENOG4105E2X shikimate dehydrogenase DXY22_03147 ENOG4105CQW ribosome biogenesis GTPase YqeH DXY22_03148 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase DXY22_03151 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase DXY22_03152 ENOG41080BT SNARE associated Golgi DXY22_03155 ENOG4105WFK nuclease DXY22_03156 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DXY22_03158 ENOG4105C0R drug resistance transporter emrb qaca subfamily DXY22_03159 ENOG4107Y5K Resolvase DXY22_03160 ENOG4105D3P Mannan endo-1,4-beta-mannosidase DXY22_03167 ENOG4106BHF DXY22_03168 ENOG4106ANW SMI1_KNR4 DXY22_03170 ENOG4108IG5 Transcriptional regulator DXY22_03172 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase DXY22_03173 ENOG4105IG6 Phage terminase, large subunit DXY22_03182 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) DXY22_03185 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DXY22_03186 ENOG4108SWU Histidine kinase DXY22_03187 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DXY22_03188 ENOG4105DHF Membrane DXY22_03189 ENOG4108UYN gCN5-related N-acetyltransferase DXY22_03190 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein DXY22_03191 ENOG41068VA DXY22_03192 ENOG41087NI Sulfite exporter TauE/SafE DXY22_03193 ENOG4105VFE sira family DXY22_03194 ENOG4107TPS domain protein DXY22_03195 ENOG4105VFE sira family DXY22_03196 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase DXY22_03197 ENOG4105XTG Pfam:DUF156 DXY22_03198 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein DXY22_03199 ENOG41090E6 transcriptional regulator MERR family DXY22_03202 ENOG4105C37 (CBS) domain DXY22_03205 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family DXY22_03206 ENOG4105H3G oxidoreductase DXY22_03207 ENOG4105PGM cation diffusion facilitator family transporter DXY22_03208 ENOG41090U3 tautomerase DXY22_03211 ENOG4105KMT branched-chain amino acid DXY22_03212 ENOG4108UMN azlc family DXY22_03213 ENOG4108ZRZ Transcriptional regulator (AsnC family) DXY22_03214 ENOG41067XF inhibitor DXY22_03217 ENOG41064BW Protein of unknown function (DUF2568) DXY22_03219 ENOG41075D4 Aminoglycoside 6-adenylyltransferase DXY22_03220 ENOG4105EA8 2-Nitropropane dioxygenase DXY22_03221 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) DXY22_03224 ENOG4108MEK Metal-binding protein YodA DXY22_03225 ENOG410904A RNA polymerase DXY22_03226 ENOG4105CPC Aldo Keto reductase DXY22_03228 ENOG4108KAM Transcriptional regulator DXY22_03229 ENOG4105C7F AcnD-accessory protein PrpF DXY22_03230 ENOG41083Q9 chitosanase DXY22_03231 ENOG4105X5K response regulator receiver protein DXY22_03232 ENOG4108VQT Alpha beta hydrolase fold protein DXY22_03233 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein DXY22_03234 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein DXY22_03236 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase DXY22_03238 ENOG4105PGS Spore coat protein DXY22_03239 ENOG4105E2A Dehydrogenase DXY22_03242 ENOG4105VUF Transcriptional regulator DXY22_03244 ENOG4105DQ4 alcohol dehydrogenase DXY22_03245 ENOG4108Z0Z intracellular protease Pfpi family DXY22_03246 ENOG4108HKT sucrose-6-phosphate hydrolase DXY22_03247 ENOG4105F3R pts system mannose fructose sorbose family iid DXY22_03248 ENOG4105ETZ PTS System DXY22_03249 ENOG4108IQ3 PTS system DXY22_03250 ENOG4105YHU PTS system DXY22_03251 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family DXY22_03252 ENOG4105C85 amino acid DXY22_03253 ENOG4105N14 lysine exporter protein LysE YggA DXY22_03254 ENOG4108NGU Transcriptional regulator DXY22_03255 ENOG4105JVQ RNA Polymerase DXY22_03256 ENOG4108P49 AntiSigma factor DXY22_03257 ENOG4105EXC Acyl-transferase DXY22_03258 ENOG4105WDR DXY22_03259 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DXY22_03260 ENOG41082JN Transcriptional regulator DXY22_03264 ENOG4105TMB Formate nitrite transporter DXY22_03266 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) DXY22_03267 ENOG4108JB9 formate dehydrogenase DXY22_03270 ENOG4105C28 cystathionine DXY22_03273 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) DXY22_03276 ENOG4107XRG penicillin-binding protein DXY22_03277 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) DXY22_03278 ENOG4105DBI uridine monophosphokinase DXY22_03279 ENOG4105CFP Peptidase U32 DXY22_03280 ENOG4105XYU peptidase (U32 family) DXY22_03282 ENOG4105HHA aminodeoxychorismate lyase DXY22_03283 ENOG4105VPH UPF0473 protein DXY22_03284 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) DXY22_03285 ENOG4105VBH UPF0297 protein DXY22_03286 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) DXY22_03287 ENOG4105C02 permease DXY22_03288 ENOG4105CDA abc transporter atp-binding protein DXY22_03289 ENOG4105CT1 (ABC) transporter DXY22_03290 ENOG4105EAD ABC transporter DXY22_03291 ENOG4105DRP amino acid AbC transporter DXY22_03293 ENOG41060CR DXY22_03295 ENOG4105C7H Helicase, RecD TraA family DXY22_03297 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) DXY22_03298 ENOG4105C3J Cysteine desulfurase DXY22_03300 ENOG4105D1H recombination factor protein RarA DXY22_03301 ENOG4105CUZ uba thif-type nad fad binding protein DXY22_03302 ENOG4105C9M aspartyl-trna synthetase DXY22_03303 ENOG4105CUT histidyl-tRNA synthetase DXY22_03305 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase DXY22_03307 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) DXY22_03308 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) DXY22_03309 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) DXY22_03310 ENOG41067VP Protein of unknown function (DUF1049) DXY22_03311 ENOG4105NCW Trka-c domain protein DXY22_03312 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) DXY22_03314 ENOG4105CKP Polysaccharide Biosynthesis Protein DXY22_03315 ENOG4108QG2 Membrane DXY22_03316 ENOG4105NAP DXY22_03317 ENOG4105VIE preprotein translocase, subunit YajC DXY22_03318 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) DXY22_03319 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) DXY22_03320 ENOG41061AI Protein of unknown function (DUF2905) DXY22_03321 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) DXY22_03322 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) DXY22_03324 ENOG4105IE8 Alpha-ketoglutarate permease DXY22_03325 ENOG4105CK5 oxidoreductase DXY22_03329 ENOG4105BZG amino acid carrier protein DXY22_03330 ENOG4105CDY transcriptional regulatory protein DXY22_03332 ENOG4106678 morphogenetic protein associated with SpoVID DXY22_03333 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) DXY22_03334 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase DXY22_03335 ENOG4108IYU L-aspartate oxidase DXY22_03338 ENOG4105CQC Prephenate dehydratase DXY22_03339 ENOG41090I5 UPF0735 ACT domain-containing protein DXY22_03340 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control DXY22_03342 ENOG4105K46 50S ribosomal protein l27 DXY22_03343 ENOG4105X36 (ribosomal) protein DXY22_03344 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) DXY22_03347 ENOG4107QMS site-determining protein DXY22_03348 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) DXY22_03349 ENOG4105YHC Rod shape-determining protein MreD DXY22_03351 ENOG4105DFF Rod shape-determining protein mreb DXY22_03352 ENOG4105W5Q DNA repair protein (RadC DXY22_03353 ENOG4108Z03 MAF-like protein DXY22_03355 ENOG4106A3R peptidase DXY22_03356 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase DXY22_03357 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) DXY22_03359 ENOG4106AR7 Spore coat protein DXY22_03360 ENOG41068KH stage VI sporulation protein D DXY22_03361 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase DXY22_03362 ENOG4105D52 delta-aminolevulinic acid dehydratase DXY22_03364 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) DXY22_03366 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) DXY22_03368 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) DXY22_03369 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) DXY22_03370 ENOG4108IUQ atp-dependent protease DXY22_03371 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) DXY22_03372 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation DXY22_03374 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DXY22_03375 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) DXY22_03376 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) DXY22_03377 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) DXY22_03378 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase DXY22_03379 ENOG4108ZP8 Acetolactate synthase small subunit DXY22_03380 ENOG4105C7K acetolactate synthase DXY22_03382 ENOG4105I4A GCN5-related N-acetyltransferase DXY22_03383 ENOG4107KM7 Heat induced stress protein YflT DXY22_03385 ENOG4105M59 Phosphodiesterase, mj0936 family DXY22_03386 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) DXY22_03387 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) DXY22_03388 ENOG4108XJQ germination protein DXY22_03389 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) DXY22_03390 ENOG41067TZ transcriptional regulator, MarR family DXY22_03391 ENOG4107Y5K Resolvase DXY22_03395 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase DXY22_03400 ENOG41068G1 DXY22_03408 ENOG4108FKH Transglycosylase SLT domain DXY22_03446 ENOG4108PNI recT protein DXY22_03447 ENOG4108NF7 phage-type endonuclease DXY22_03453 ENOG4108ZUE Phage regulatory protein rha DXY22_03458 ENOG41067QW Transcriptional regulator DXY22_03461 ENOG4105PFC Transcriptional regulator DXY22_03463 ENOG4105E33 succinate dehydrogenase DXY22_03465 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit DXY22_03467 ENOG4105CFH Aspartokinase DXY22_03468 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) DXY22_03469 ENOG4105K63 Thioredoxin DXY22_03470 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) DXY22_03472 ENOG4105C10 Electron transfer flavoprotein DXY22_03473 ENOG4105BZJ Electron transfer flavoprotein DXY22_03474 ENOG41060WC Enoyl-CoA hydratase DXY22_03475 ENOG4107Z3H Transcriptional regulator, TetR family DXY22_03476 ENOG4105CEY Amp-dependent synthetase and ligase DXY22_03478 ENOG4105C98 muts2 protein DXY22_03479 ENOG4105DCG PHP domain protein DXY22_03482 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) DXY22_03483 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) DXY22_03484 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) DXY22_03485 ENOG4108RWN rrna methyltransferase DXY22_03486 ENOG41067MF small acid-soluble spore protein DXY22_03488 ENOG4105CQB FAD linked oxidase domain protein DXY22_03489 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DXY22_03492 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) DXY22_03493 ENOG4105DRS transport system, permease DXY22_03496 ENOG4108MDK Dehydrogenase DXY22_03498 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase DXY22_03499 ENOG4105EF1 ribulokinase DXY22_03501 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase DXY22_03502 ENOG4105CN9 Peptidase m42 family protein DXY22_03504 ENOG410696E Membrane DXY22_03505 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) DXY22_03506 ENOG4105VJV 50s ribosomal protein L35 DXY22_03507 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) DXY22_03509 ENOG41067MG lrgb family DXY22_03511 ENOG4105DY9 regulatoR DXY22_03512 ENOG4108HRK Histidine kinase DXY22_03514 ENOG4105C22 threonyL-tRNA synthetase DXY22_03515 ENOG4108TDW sporulation protein YtxC DXY22_03519 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) DXY22_03520 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) DXY22_03521 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DXY22_03522 ENOG4105KVH Transcriptional regulator DXY22_03523 ENOG4105F27 Major Facilitator DXY22_03524 ENOG4105CV8 reductase DXY22_03525 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) DXY22_03527 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) DXY22_03528 ENOG4105C2M dna polymerase I DXY22_03529 ENOG4105BZU Histidine kinase DXY22_03530 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DXY22_03531 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) DXY22_03532 ENOG4108HMX isocitrate dehydrogenase (NADP) DXY22_03533 ENOG4105BZN citrate synthase DXY22_03535 ENOG4108REF Sporulation integral membrane protein ytvi DXY22_03536 ENOG4105FS0 cytoplasmic membrane protein DXY22_03537 ENOG4105CA9 Pyruvate kinase DXY22_03538 ENOG4105CTQ phosphohexokinase DXY22_03540 ENOG4108IEY Carboxyl transferase domain DXY22_03541 ENOG4105C6K Malic enzyme DXY22_03542 ENOG4105C0B DNA polymerase III (alpha subunit) DXY22_03543 ENOG4105VV2 DXY22_03545 ENOG4106EVM DXY22_03546 ENOG4105SFS phosphoesterase RecJ domain protein DXY22_03549 ENOG410635A Membrane DXY22_03550 ENOG4105CH2 amidohydrolase DXY22_03554 ENOG4105DEN Luciferase family DXY22_03555 ENOG4105CDA abc transporter atp-binding protein DXY22_03560 ENOG4108XSB acetyltransferase, (GNAT) family DXY22_03561 ENOG4108KSA LysR family transcriptional regulator DXY22_03562 ENOG4105E8R UPF0173 metal-dependent hydrolase DXY22_03565 ENOG4105CH7 arginosuccinase DXY22_03566 ENOG4105CDH Citrulline--aspartate ligase DXY22_03567 ENOG4105EPU Molybdenum cofactor synthesis domain protein DXY22_03568 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) DXY22_03570 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) DXY22_03571 ENOG4105KBJ sporulation protein ytfj DXY22_03573 ENOG4105VK3 rdd domain containing protein DXY22_03574 ENOG4105D07 Signal peptide peptidase, SppA DXY22_03575 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) DXY22_03576 ENOG4105EFZ amidohydrolase DXY22_03577 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) DXY22_03584 ENOG4105U5Y Transcriptional regulator DXY22_03586 ENOG4105BZU Histidine kinase DXY22_03587 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) DXY22_03589 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) DXY22_03591 ENOG4105F1V Acetoin utilization protein DXY22_03592 ENOG4105W87 Cbs domain DXY22_03593 ENOG4105DGU Histone deacetylase DXY22_03594 ENOG4105ER2 Ompa motb domain protein DXY22_03595 ENOG4107R0U MotA TolQ exbB proton channel DXY22_03596 ENOG4105ETE Transcriptional regulator (LacI family DXY22_03597 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase DXY22_03601 ENOG4105DFU Cell wall formation (By similarity) DXY22_03603 ENOG4108VDD TRNA binding domain protein DXY22_03606 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ DXY22_03609 ENOG4105C6K Malic enzyme DXY22_03610 ENOG4105C8F Beta-lactamase domain protein DXY22_03611 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) DXY22_03613 ENOG4108V15 phosphotransferase enzyme family DXY22_03614 ENOG4108IUM Glycogen debranching enzyme DXY22_03617 ENOG4107F58 2'-5' rna ligase DXY22_03618 ENOG4105C6T cysteine synthase DXY22_03619 ENOG4107QSE Dipeptidase DXY22_03620 ENOG4105C7N Xanthine uracil vitamin C permease DXY22_03623 ENOG4105YW5 deoR family transcriptional regulator DXY22_03626 ENOG4105CBX hi0933 family DXY22_03627 ENOG4105C94 Transporter DXY22_03629 ENOG4105MU9 integral membrane protein DXY22_03630 ENOG4105DDC Oxidoreductase domain protein DXY22_03632 ENOG4105F5H Glycosyl Hydrolase Family 88 DXY22_03634 ENOG41075H3 AraC family transcriptional regulator DXY22_03636 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component DXY22_03638 ENOG4106A3M Cytochrome p-450 DXY22_03639 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) DXY22_03641 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) DXY22_03642 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) DXY22_03644 ENOG4105NTD Inherit from COG: Hydrolase DXY22_03650 ENOG41085GJ domain protein DXY22_03651 ENOG4105C8T Leucyl-tRNA synthetase DXY22_03653 ENOG4105BZU Histidine kinase DXY22_03654 ENOG410605W Major Facilitator DXY22_03655 ENOG4106UBQ DXY22_03657 ENOG4105C19 ABC transporter DXY22_03658 ENOG4105EWM Histidine kinase DXY22_03660 ENOG4107R34 abc transporter permease protein DXY22_03661 ENOG4105C19 ABC transporter DXY22_03664 ENOG4105DVE abc transporter atp-binding protein DXY22_03665 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family DXY22_03668 ENOG4105N5T Radical SAM Protein DXY22_03671 ENOG4105E8V Alpha Beta Hydrolase Fold protein DXY22_03672 ENOG4108Z0R Transferase DXY22_03673 ENOG4105C85 amino acid DXY22_03674 ENOG4105CAQ asparagine synthetase DXY22_03675 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP DXY22_03676 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase DXY22_03679 ENOG4105D2X ABC transporter substrate-binding protein DXY22_03681 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component DXY22_03684 ENOG4108RMU ferritin dps family protein DXY22_03687 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) DXY22_03688 ENOG4108V2W Carbonate dehydratase DXY22_03693 ENOG4105CC5 ABC transporter DXY22_03694 ENOG4105CC5 ABC transporter DXY22_03695 ENOG4105DIK (ABC) transporter DXY22_03696 ENOG4105DSE periplasmic solute binding protein DXY22_03697 ENOG4105DTQ mandelate racemase muconate lactonizing DXY22_03698 ENOG4105CEY Amp-dependent synthetase and ligase DXY22_03699 ENOG4108IPT Naphthoate synthase DXY22_03700 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) DXY22_03701 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) DXY22_03702 ENOG4105E4F Isochorismate synthase DXY22_03706 ENOG4108IAJ Nad-dependent epimerase dehydratase DXY22_03707 ENOG4107SBE Glycosyl transferase (Group 1 DXY22_03710 ENOG4107SBE Glycosyl transferase (Group 1 DXY22_03711 ENOG4108KS4 Spore coat protein DXY22_03714 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) DXY22_03716 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) DXY22_03742 ENOG4105N67 Proton-coupled thiamine transporter YuaJ DXY22_03743 ENOG4105VRR gCN5-related N-acetyltransferase DXY22_03744 ENOG4105DZ6 Band 7 protein DXY22_03746 ENOG4106DF1 DXY22_03747 ENOG4108VNY MOSC domain protein DXY22_03748 ENOG4108JB8 alcohol dehydrogenase DXY22_03750 ENOG4105TRT Transcriptional regulator DXY22_03753 ENOG4105CZN Potassium uptake protein DXY22_03754 ENOG4107I77 yiaA/B two helix domain DXY22_03755 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj DXY22_03759 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) DXY22_03761 ENOG4105EE0 oxidoreductase DXY22_03762 ENOG4105DKG l-rhamnose isomerase DXY22_03763 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) DXY22_03764 ENOG4105DET Rhamnulokinase DXY22_03765 ENOG4105E98 transcriptional regulator DeoR family DXY22_03767 ENOG4105C8Q Methyl-accepting chemotaxis DXY22_03768 ENOG4105C8Q Methyl-accepting chemotaxis DXY22_03769 ENOG4105C8Q Methyl-accepting chemotaxis DXY22_03770 ENOG4105C8Q Methyl-accepting chemotaxis DXY22_03773 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme DXY22_03775 ENOG4105C37 (CBS) domain DXY22_03778 ENOG4107PBV potassium channel DXY22_03779 ENOG4107PBV potassium channel DXY22_03782 ENOG4107QYV phosphohexose isomerase DXY22_03784 ENOG4107QW4 alcohol dehydrogenase DXY22_03785 ENOG4105WG9 Conserved Protein DXY22_03787 ENOG4105CHM Aminotransferase DXY22_03788 ENOG4108ZB6 transcriptional regulator AsnC family DXY22_03789 ENOG4108MUZ hydrolase DXY22_03791 ENOG4105C87 Aminotransferase class I and II DXY22_03792 ENOG4108HGU Histidine kinase DXY22_03793 ENOG4105Y38 Kinase-associated protein B DXY22_03797 ENOG4105BZ4 penicillin-binding protein DXY22_03798 ENOG4105KIR Thiol-disulfide oxidoreductase dcc DXY22_03801 ENOG4108MRH transcriptional regulatory protein DXY22_03802 ENOG4105DIH basic membrane DXY22_03803 ENOG4108JQ9 ABC transporter DXY22_03804 ENOG4105UIB (ABC) transporter DXY22_03808 ENOG4105D65 subunit l DXY22_03809 ENOG4105HC0 Na H antiporter DXY22_03810 ENOG4108ZE9 Monovalent cation H antiporter subunit C DXY22_03811 ENOG4108JPZ Monovalent cation H antiporter subunit D DXY22_03812 ENOG4105SC1 monovalent cation H antiporter subunit E DXY22_03814 ENOG4105KJM monovalent cation h antiporter subunit g DXY22_03815 ENOG4105KA0 thioesterase Superfamily protein DXY22_03817 ENOG4105BZU Histidine kinase DXY22_03822 ENOG4105D58 Diguanylate phosphodiesterase DXY22_03823 ENOG4105DAP Nicotinate phosphoribosyltransferase DXY22_03828 ENOG4105C02 permease DXY22_03832 ENOG410904N short-chain dehydrogenase reductase DXY22_03839 ENOG4108K8K Transcriptional regulator DXY22_03840 ENOG4105DCF alanine dehydrogenase DXY22_03842 ENOG4105WQT MbtH domain protein DXY22_03843 ENOG4105CEY Amp-dependent synthetase and ligase DXY22_03844 ENOG4105WQI isochorismatase DXY22_03845 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase DXY22_03846 ENOG4105E4F Isochorismate synthase DXY22_03847 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase DXY22_03848 ENOG4105NIV Esterase DXY22_03852 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) DXY22_03854 ENOG41069ER domain protein DXY22_03856 ENOG4105CEP NADH dehydrogenase DXY22_03857 ENOG4105CAY ferredoxin--nadp reductase DXY22_03861 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 DXY22_03862 ENOG4108YX9 iron--sulfur cluster insertion protein erpA DXY22_03865 ENOG4105ZKE UPF0349 protein DXY22_03868 ENOG41083MR nifu domain-containing protein DXY22_03869 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein DXY22_03870 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) DXY22_03871 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) DXY22_03872 ENOG4105D6E homoserine dehydrogenase DXY22_03874 ENOG4108W5N phosphatidylglycerophosphatase a DXY22_03875 ENOG4105D4U had-superfamily hydrolase, subfamily iia DXY22_03877 ENOG4105MMD transcriptional regulator DXY22_03878 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DXY22_03879 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) DXY22_03880 ENOG4105FAA peptidase M23 DXY22_03881 ENOG4108YTE sporulation protein YunB DXY22_03882 ENOG4105KZD Domain of unknown function (DUF1805) DXY22_03883 ENOG4107R8B 5'-nucleotidase DXY22_03885 ENOG4105I3N Conserved Protein DXY22_03887 ENOG4105CD3 dihydroorotase DXY22_03888 ENOG4105G9B Transcriptional regulator DXY22_03891 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) DXY22_03892 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) DXY22_03893 ENOG4105VT2 5-hydroxyisourate hydrolase DXY22_03894 ENOG4107YV9 domain protein DXY22_03895 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding DXY22_03898 ENOG4105XRQ Xanthine dehydrogenase accessory factor DXY22_03900 ENOG4105C5R Aminotransferase DXY22_03902 ENOG4108K8S endonuclease I DXY22_03903 ENOG4108IJ9 (ABC) transporter DXY22_03904 ENOG4105FDP GntR family transcriptional regulator DXY22_03905 ENOG4108KPW sugar kinase DXY22_03906 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component DXY22_03907 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component DXY22_03908 ENOG4105XN3 extracellular solute-binding protein family 1 DXY22_03909 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine DXY22_03910 ENOG4105PKS Excinuclease abc c subunit domain protein DXY22_03911 ENOG4107VFR oxidoreductase DXY22_03914 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase DXY22_03915 ENOG4105DIW FeS assembly protein SUFB DXY22_03916 ENOG4108UNV SUF system FeS assembly protein, NifU family DXY22_03917 ENOG4105C9B Cysteine desulfurase DXY22_03918 ENOG4105JRK feS assembly protein SufD DXY22_03919 ENOG4105C3K feS assembly ATPase SufC DXY22_03921 ENOG4105D01 (LipO)protein DXY22_03922 ENOG4108UMI ABC transporter, permease DXY22_03923 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) DXY22_03928 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) DXY22_03929 ENOG41080E8 Transcriptional regulator, Spx MgsR family DXY22_03930 ENOG4105C1G acyl-Coa dehydrogenase DXY22_03931 ENOG4105CHU acetyl-coa acetyltransferase DXY22_03937 ENOG41067TZ transcriptional regulator, MarR family DXY22_03938 ENOG4105C0R drug resistance transporter emrb qaca subfamily DXY22_03939 ENOG4105MDS 4-oxalocrotonate tautomerase DXY22_03941 ENOG4105EGI Transcriptional regulator DXY22_03943 ENOG4105E0A ABC, transporter DXY22_03946 ENOG4105E1F short-chain dehydrogenase reductase DXY22_03947 ENOG4105HUF DNA protection during starvation protein DXY22_03948 ENOG4105C0H protease DXY22_03950 ENOG4105F3H Histidine kinase DXY22_03951 ENOG41067SE Tetr family transcriptional regulator DXY22_03952 ENOG4105C9Q fumarate hydratase class II DXY22_03957 ENOG4105WH1 Two component transcriptional regulator luxr family DXY22_03958 ENOG4105ENE Histidine kinase DXY22_03961 ENOG41087YS Phage shock protein A DXY22_03964 ENOG4108WBT adenosyltransferase DXY22_03965 ENOG4105E0A ABC, transporter DXY22_03966 ENOG4105EHG Permease protein DXY22_03967 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) DXY22_03968 ENOG4105EWI Short-chain dehydrogenase reductase Sdr DXY22_03969 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein DXY22_03971 ENOG4105DPZ Two component transcriptional regulator (Winged helix family DXY22_03973 ENOG4106DF4 Sigma-70, region 4 DXY22_03975 ENOG4105F0F Oxalate decarboxylase DXY22_03977 ENOG4107RBB ABC transporter, permease DXY22_03978 ENOG4105C19 ABC transporter DXY22_03979 ENOG4108WMK Efflux transporter RND family MFP subunit DXY22_03980 ENOG4105E0A ABC, transporter DXY22_03981 ENOG4105EHG Permease protein DXY22_03982 ENOG4105DQ5 transport system permease protein DXY22_03985 ENOG4105D5Q Arginine ornithine antiporter DXY22_03987 ENOG4107K5X Membrane-bound metal-dependent hydrolase DXY22_03988 ENOG4107QZ2 Sulfatase DXY22_03989 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family DXY22_03990 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein DXY22_03991 ENOG4105E0C molybdate abc transporter DXY22_03994 ENOG4105EEQ Na H antiporter DXY22_03995 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) DXY22_03996 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) DXY22_03997 ENOG4105EEM helicase DXY22_03999 ENOG4105EN6 Membrane DXY22_04001 ENOG4107ZQN disulfide bond DXY22_04002 ENOG4105C59 p-type ATPase DXY22_04003 ENOG4105C59 p-type ATPase DXY22_04004 ENOG410681U heavy metal transport detoxification protein DXY22_04005 ENOG4105VPX protein, conserved in bacteria DXY22_04006 ENOG4105D9R oxidoreductase DXY22_04007 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) DXY22_04008 ENOG4105ME7 Membrane DXY22_04009 ENOG4105RXJ DXY22_04010 ENOG4105KPY Small multidrug resistance protein DXY22_04011 ENOG4105KBX Transcriptional regulator, TetR family DXY22_04012 ENOG4105EWI Short-chain dehydrogenase reductase Sdr DXY22_04014 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) DXY22_04015 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) DXY22_04017 ENOG4105XZU Preprotein translocase, subunit SecG DXY22_04022 ENOG4105KVH Transcriptional regulator DXY22_04023 ENOG4105C8Q Methyl-accepting chemotaxis DXY22_04024 ENOG4105R40 Glycine betaine carnitine choline DXY22_04025 ENOG4108HQR Glycine betaine DXY22_04026 ENOG4105E90 ABC transporter DXY22_04027 ENOG4108IJ8 ABC transporter DXY22_04028 ENOG4107HG4 Transcriptional regulator DXY22_04030 ENOG4105H5S DXY22_04033 ENOG41082BM Transcriptional regulator, arsr family DXY22_04034 ENOG4105R40 Glycine betaine carnitine choline DXY22_04035 ENOG4108HQR Glycine betaine DXY22_04036 ENOG4105E90 ABC transporter DXY22_04037 ENOG4108IJ8 ABC transporter DXY22_04038 ENOG4107HG4 Transcriptional regulator DXY22_04039 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein DXY22_04040 ENOG4108QCI YvbH-like oligomerisation region DXY22_04042 ENOG4105T65 Membrane-associated protein DXY22_04043 ENOG4108W0I acetyltransferase DXY22_04044 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) DXY22_04045 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) DXY22_04046 ENOG4105CP7 Triose-phosphate isomerase DXY22_04047 ENOG4105BZA Phosphoglycerate kinase DXY22_04048 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase DXY22_04051 ENOG4105CMD Transcriptional regulator, GntR family DXY22_04052 ENOG4105DEN Luciferase family DXY22_04053 ENOG4105GZI Transcriptional regulator DXY22_04054 ENOG4107RT3 EamA-like transporter family DXY22_04056 ENOG4105VRS hydrolase family 18 DXY22_04057 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) DXY22_04058 ENOG4107QR9 Iron-sulfur cluster binding protein DXY22_04059 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) DXY22_04061 ENOG4105BZU Histidine kinase DXY22_04062 ENOG4105KCT ABC transporter DXY22_04063 ENOG4108M15 ABC transporter DXY22_04064 ENOG4107R6F Alpha Beta Hydrolase Fold protein DXY22_04065 ENOG4108MJI response regulator DXY22_04068 ENOG4105EG2 ABC transporter, permease DXY22_04070 ENOG4107FKK extracellular solute-binding protein family 1 DXY22_04072 ENOG4105JXH GntR family transcriptional regulator DXY22_04073 ENOG4105DAA L-lactate DXY22_04074 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) DXY22_04076 ENOG4108ZPC Polysaccharide pyruvyl transferase DXY22_04077 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase DXY22_04078 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family DXY22_04079 ENOG4105D3Q Sugar transferase DXY22_04081 ENOG4105K64 Glycosyl transferase, family 2 DXY22_04083 ENOG4107QRS glycosyltransferase group 2 family protein DXY22_04084 ENOG41068W6 Capsular polysaccharide biosynthesis protein DXY22_04085 ENOG4108KMV Glycosyl transferase (Group 1 DXY22_04086 ENOG4105K64 Glycosyl transferase, family 2 DXY22_04087 ENOG4108PQP glycosyl transferase group 1 DXY22_04089 ENOG4108QV3 biosynthesis protein DXY22_04090 ENOG4105HTX biosynthesis protein DXY22_04092 ENOG4105EBR Carboxylesterase DXY22_04094 ENOG4105PY6 Phenolic acid decarboxylase DXY22_04095 ENOG4105NI3 Protein of unknown function (DUF3237) DXY22_04097 ENOG4105FQP Beta-lactamase DXY22_04098 ENOG4105EDQ levansucrase EC 2.4.1.10 DXY22_04099 ENOG4108HKT sucrose-6-phosphate hydrolase DXY22_04100 ENOG4107QTZ amino acid DXY22_04105 ENOG4105DNP FAD linked oxidase domain protein DXY22_04106 ENOG4105IRW patatin-like phospholipase family protein DXY22_04108 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) DXY22_04109 ENOG4107URF beta-phospho-glucomutase DXY22_04110 ENOG4105CG3 alpha amylase, catalytic region DXY22_04113 ENOG4105EG2 ABC transporter, permease DXY22_04114 ENOG4105D56 permease protein DXY22_04115 ENOG4107FKK extracellular solute-binding protein family 1 DXY22_04116 ENOG4108IUK alpha amylase, catalytic DXY22_04117 ENOG4105FKQ transcriptional regulator DXY22_04118 ENOG4108URH decarboxylase DXY22_04119 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain DXY22_04120 ENOG4105CHH sulfate transporter DXY22_04121 ENOG4108V2W Carbonate dehydratase DXY22_04122 ENOG4105C5I Dehydrogenase DXY22_04124 ENOG4105C19 ABC transporter DXY22_04125 ENOG4105EWM Histidine kinase DXY22_04127 ENOG4107A6P DXY22_04128 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase DXY22_04129 ENOG4105KRI phosphocarrier protein (HPr DXY22_04130 ENOG4105CIE May be required for sporulation (By similarity) DXY22_04131 ENOG4105CHW UPF0052 protein DXY22_04132 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) DXY22_04133 ENOG4108Z4K mutator MutT protein DXY22_04134 ENOG4105C3M thioredoxin reductase DXY22_04137 ENOG4105BZ1 (ABC) transporter DXY22_04139 ENOG4106FGC