locus-tag	class	description
DXY22_00002	COG0140	phosphoribosyl-ATP diphosphatase activity
DXY22_00002	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DXY22_00003	COG0107	imidazoleglycerol-phosphate synthase activity
DXY22_00004	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
DXY22_00005	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
DXY22_00006	COG0131	Imidazoleglycerol-phosphate dehydratase
DXY22_00007	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
DXY22_00008	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DXY22_00009	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
DXY22_00010	COG4990	cell redox homeostasis
DXY22_00011	COG5297	Belongs to the glycosyl hydrolase family 6
DXY22_00012	COG0110	maltose O-acetyltransferase activity
DXY22_00013	COG0546	phosphoglycolate phosphatase activity
DXY22_00014	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DXY22_00015	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DXY22_00016	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
DXY22_00017	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DXY22_00018	COG0363	glucosamine-6-phosphate deaminase activity
DXY22_00019	COG2188	Transcriptional regulator
DXY22_00020	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DXY22_00021	COG1846	Transcriptional regulator
DXY22_00022	COG2124	cytochrome p450
DXY22_00024	COG1846	Transcriptional regulator
DXY22_00025	COG2814	Major facilitator Superfamily
DXY22_00026	COG1950	PFAM Membrane protein of
DXY22_00027	COG1983	PspC domain protein
DXY22_00028	COG3595	metallopeptidase activity
DXY22_00031	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DXY22_00032	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DXY22_00033	COG0556	nucleotide-excision repair
DXY22_00034	COG4897	Protein conserved in bacteria
DXY22_00035	COG0574	Belongs to the PEP-utilizing enzyme family
DXY22_00035	COG3848	Pyruvate phosphate dikinase
DXY22_00036	COG1309	transcriptional regulator
DXY22_00037	COG2814	Major facilitator Superfamily
DXY22_00038	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DXY22_00040	COG0793	Belongs to the peptidase S41A family
DXY22_00040	COG3409	Peptidoglycan-binding domain 1 protein
DXY22_00041	COG2177	Part of the ABC transporter FtsEX involved in
DXY22_00042	COG2884	Cell division ATP-binding protein ftsE
DXY22_00043	COG2010	Cytochrome c
DXY22_00044	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DXY22_00045	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
DXY22_00046	COG0653	protein targeting
DXY22_00047	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DXY22_00050	COG1516	flagellar protein fliS
DXY22_00051	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DXY22_00052	COG1334	flagellar protein FlaG
DXY22_00053	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DXY22_00054	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
DXY22_00055	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
DXY22_00057	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DXY22_00058	COG4786	Flagellar basal body rod
DXY22_00058	COG1256	bacterial-type flagellum assembly
DXY22_00059	COG3418	PFAM FlgN family protein
DXY22_00060	COG2747	anti-sigma28 factor FlgM
DXY22_00062	COG1040	competence protein
DXY22_00064	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
DXY22_00065	COG1307	EDD domain protein, DegV family
DXY22_00066	COG2197	response regulator
DXY22_00067	COG4585	Histidine kinase
DXY22_00068	COG1739	Uncharacterized protein family UPF0029
DXY22_00069	COG1316	TRANSCRIPTIONal
DXY22_00070	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DXY22_00071	COG0438	transferase activity, transferring glycosyl groups
DXY22_00072	COG1215	transferase activity, transferring glycosyl groups
DXY22_00073	COG3206	protein involved in exopolysaccharide biosynthesis
DXY22_00074	COG3307	-O-antigen
DXY22_00075	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DXY22_00076	COG0297	glycogen (starch) synthase activity
DXY22_00076	COG0438	transferase activity, transferring glycosyl groups
DXY22_00077	COG2244	polysaccharide biosynthetic process
DXY22_00080	COG0860	N-Acetylmuramoyl-L-alanine amidase
DXY22_00080	COG2247	cell wall binding repeat
DXY22_00081	COG2385	sporulation resulting in formation of a cellular spore
DXY22_00081	COG2247	cell wall binding repeat
DXY22_00083	COG1316	TRANSCRIPTIONal
DXY22_00084	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DXY22_00088	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DXY22_00089	COG1134	teichoic acid transport
DXY22_00090	COG1682	transport, permease protein
DXY22_00091	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DXY22_00091	COG1215	transferase activity, transferring glycosyl groups
DXY22_00092	COG0463	Glycosyl transferase, family 2
DXY22_00101	COG4193	domain, Protein
DXY22_00102	COG1482	cell wall glycoprotein biosynthetic process
DXY22_00103	COG0697	spore germination
DXY22_00104	COG0814	amino acid
DXY22_00106	COG2814	Major facilitator Superfamily
DXY22_00107	COG1316	TRANSCRIPTIONal
DXY22_00108	COG0561	phosphatase activity
DXY22_00109	COG0791	NLP P60 protein
DXY22_00111	COG2843	Capsule synthesis protein
DXY22_00113	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DXY22_00114	COG1609	Transcriptional regulator
DXY22_00115	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DXY22_00116	COG1869	D-ribose catabolic process
DXY22_00117	COG1129	ABC transporter
DXY22_00118	COG1172	Belongs to the binding-protein-dependent transport system permease family
DXY22_00119	COG1879	ABC-type sugar transport system periplasmic component
DXY22_00120	COG3103	Sh3 type 3 domain protein
DXY22_00122	COG2249	NAD(P)H dehydrogenase (quinone) activity
DXY22_00123	COG3527	Alpha-acetolactate decarboxylase
DXY22_00124	COG0028	Belongs to the TPP enzyme family
DXY22_00125	COG0583	DNA-binding transcription factor activity
DXY22_00126	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DXY22_00129	COG5337	Spore coat protein CotH
DXY22_00131	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DXY22_00133	COG0405	Gamma-glutamyltransferase
DXY22_00134	COG1522	sequence-specific DNA binding
DXY22_00135	COG2059	Chromate
DXY22_00136	COG2059	Chromate
DXY22_00138	COG0655	NAD(P)H dehydrogenase (quinone) activity
DXY22_00139	COG0583	DNA-binding transcription factor activity
DXY22_00142	COG5444	nuclease activity
DXY22_00145	COG3878	Protein conserved in bacteria
DXY22_00146	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DXY22_00147	COG4464	protein tyrosine phosphatase activity
DXY22_00148	COG0489	protein tyrosine kinase activity
DXY22_00149	COG3944	biosynthesis protein
DXY22_00151	COG4715	Zinc finger, swim domain protein
DXY22_00152	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DXY22_00153	COG0561	phosphatase activity
DXY22_00154	COG1349	DNA-binding transcription factor activity
DXY22_00155	COG0629	single-stranded DNA binding
DXY22_00158	COG3764	Sortase (surface protein transpeptidase)
DXY22_00161	COG3279	Response regulator of the LytR AlgR family
DXY22_00162	COG0745	RESPONSE REGULATOR receiver
DXY22_00162	COG2972	Histidine kinase
DXY22_00163	COG0745	RESPONSE REGULATOR receiver
DXY22_00163	COG2972	Histidine kinase
DXY22_00164	COG1970	mechanosensitive ion channel activity
DXY22_00165	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DXY22_00166	COG0457	Tetratricopeptide repeat
DXY22_00167	COG4786	Flagellar basal body rod
DXY22_00168	COG4786	Flagellar basal body rod
DXY22_00169	COG1077	Cell shape determining protein MreB Mrl
DXY22_00170	COG1609	Transcriptional regulator
DXY22_00171	COG1846	Transcriptional regulator
DXY22_00172	COG2814	Major facilitator Superfamily
DXY22_00173	COG3420	alginic acid biosynthetic process
DXY22_00174	COG1953	Uracil, thiamine, allantoin
DXY22_00175	COG0477	Major facilitator Superfamily
DXY22_00176	COG1335	isochorismatase
DXY22_00178	COG0004	ammonium transporteR
DXY22_00179	COG0347	Belongs to the P(II) protein family
DXY22_00180	COG0671	phosphoesterase, PA-phosphatase related
DXY22_00184	COG0739	heme binding
DXY22_00185	COG1247	-acetyltransferase
DXY22_00188	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DXY22_00189	COG0789	Transcriptional regulator
DXY22_00191	COG2910	NAD(P)H-binding
DXY22_00192	COG1959	2 iron, 2 sulfur cluster binding
DXY22_00193	COG0804	urea catabolic process
DXY22_00194	COG0832	Belongs to the urease beta subunit family
DXY22_00195	COG0831	urea catabolic process
DXY22_00197	COG3237	CsbD-like
DXY22_00198	COG1994	Peptidase M50
DXY22_00199	COG0457	Tetratricopeptide repeat
DXY22_00200	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DXY22_00201	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DXY22_00203	COG2304	oxidoreductase activity
DXY22_00204	COG2304	oxidoreductase activity
DXY22_00205	COG2385	sporulation resulting in formation of a cellular spore
DXY22_00206	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DXY22_00208	COG4836	Membrane
DXY22_00210	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DXY22_00211	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DXY22_00212	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DXY22_00213	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DXY22_00214	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DXY22_00215	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DXY22_00217	COG0356	it plays a direct role in the translocation of protons across the membrane
DXY22_00219	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DXY22_00220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DXY22_00221	COG4475	Protein of unknown function (DUF436)
DXY22_00222	COG0698	ribose 5-phosphate isomerase
DXY22_00223	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DXY22_00224	COG1971	Probably functions as a manganese efflux pump
DXY22_00225	COG0009	L-threonylcarbamoyladenylate synthase
DXY22_00226	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DXY22_00230	COG2890	protein-(glutamine-N5) methyltransferase activity
DXY22_00231	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DXY22_00232	COG0346	lactoylglutathione lyase activity
DXY22_00233	COG0789	Transcriptional regulator
DXY22_00234	COG0679	Auxin Efflux Carrier
DXY22_00235	COG0281	malic enzyme
DXY22_00236	COG1435	thymidine kinase activity
DXY22_00238	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DXY22_00239	COG1494	fructose-1,6-bisphosphatase
DXY22_00240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
DXY22_00241	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DXY22_00242	COG0191	fructose-bisphosphate aldolase activity
DXY22_00243	COG2204	response regulator
DXY22_00244	COG4821	SIS domain
DXY22_00245	COG0504	CTP synthase activity
DXY22_00246	COG3343	RNA polymerase activity
DXY22_00247	COG1960	acyl-CoA dehydrogenase activity
DXY22_00248	COG0247	lactate metabolic process
DXY22_00248	COG2181	nitrate reductase activity
DXY22_00249	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DXY22_00250	COG4294	response to UV
DXY22_00252	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DXY22_00253	COG1132	(ABC) transporter
DXY22_00254	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DXY22_00255	COG2181	nitrate reductase activity
DXY22_00256	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
DXY22_00257	COG1140	nitrate reductase beta subunit
DXY22_00258	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
DXY22_00259	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DXY22_00261	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DXY22_00262	COG2223	nitrite transmembrane transporter activity
DXY22_00263	COG0018	arginyl-trna synthetase
DXY22_00264	COG4506	Protein conserved in bacteria
DXY22_00266	COG0535	radical SAM domain protein
DXY22_00268	COG1131	(ABC) transporter
DXY22_00269	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DXY22_00270	COG0612	Peptidase, M16
DXY22_00271	COG0612	Peptidase, M16
DXY22_00273	COG3391	amine dehydrogenase activity
DXY22_00274	COG3391	amine dehydrogenase activity
DXY22_00275	COG0457	Tetratricopeptide repeat
DXY22_00277	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DXY22_00278	COG0010	Belongs to the arginase family
DXY22_00279	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DXY22_00280	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DXY22_00282	COG1994	Peptidase M50
DXY22_00283	COG1942	4-Oxalocrotonate Tautomerase
DXY22_00284	COG1846	Transcriptional regulator
DXY22_00285	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DXY22_00287	COG0477	Major facilitator Superfamily
DXY22_00288	COG1959	2 iron, 2 sulfur cluster binding
DXY22_00289	COG3465	dGTPase activity
DXY22_00290	COG1078	dGTPase activity
DXY22_00291	COG4844	belongs to the
DXY22_00293	COG0697	spore germination
DXY22_00294	COG0095	Lipoate-protein ligase
DXY22_00295	COG0583	DNA-binding transcription factor activity
DXY22_00296	COG0280	phosphate acetyltransferase
DXY22_00298	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_00299	COG0436	Aminotransferase
DXY22_00300	COG2814	Major facilitator Superfamily
DXY22_00301	COG0151	Belongs to the GarS family
DXY22_00302	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_00303	COG1917	Cupin 2, conserved barrel domain protein
DXY22_00304	COG0077	Prephenate dehydratase
DXY22_00305	COG2814	Major facilitator Superfamily
DXY22_00306	COG0833	amino acid
DXY22_00307	COG4187	Peptidase family M20/M25/M40
DXY22_00308	COG1012	belongs to the aldehyde dehydrogenase family
DXY22_00309	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DXY22_00311	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
DXY22_00312	COG1091	dTDP-4-dehydrorhamnose reductase activity
DXY22_00313	COG1088	dTDP-glucose 4,6-dehydratase activity
DXY22_00314	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
DXY22_00315	COG3980	spore coat polysaccharide biosynthesis protein
DXY22_00316	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
DXY22_00317	COG2089	acid synthase
DXY22_00318	COG0456	acetyltransferase
DXY22_00319	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DXY22_00320	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DXY22_00321	COG0463	Glycosyl transferase, family 2
DXY22_00323	COG2363	Small membrane protein
DXY22_00324	COG2233	PERMEase
DXY22_00326	COG1012	belongs to the aldehyde dehydrogenase family
DXY22_00327	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DXY22_00328	COG1216	Glycosyl transferase, family 2
DXY22_00331	COG1695	Transcriptional regulator
DXY22_00332	COG0351	phosphomethylpyrimidine kinase
DXY22_00334	COG1621	beta-fructofuranosidase activity
DXY22_00335	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY22_00335	COG1263	PTS System
DXY22_00336	COG2116	formate transmembrane transporter activity
DXY22_00337	COG3711	transcriptional antiterminator
DXY22_00339	COG1404	Belongs to the peptidase S8 family
DXY22_00340	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DXY22_00341	COG0778	Nitroreductase
DXY22_00342	COG0772	Belongs to the SEDS family
DXY22_00344	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DXY22_00345	COG1845	cytochrome c oxidase, subunit III
DXY22_00346	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DXY22_00347	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DXY22_00348	COG2261	transglycosylase associated protein
DXY22_00349	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
DXY22_00350	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
DXY22_00351	COG2246	polysaccharide biosynthetic process
DXY22_00352	COG1309	transcriptional regulator
DXY22_00354	COG3162	membrane
DXY22_00355	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DXY22_00356	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DXY22_00357	COG2837	iron assimilation
DXY22_00358	COG2822	iron ion transport
DXY22_00359	COG0672	)-iron permease
DXY22_00360	COG0352	thiamine-phosphate diphosphorylase activity
DXY22_00361	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
DXY22_00362	COG0583	DNA-binding transcription factor activity
DXY22_00363	COG1380	Effector of murein hydrolase LrgA
DXY22_00364	COG1346	cytolysis
DXY22_00365	COG2814	Major facilitator Superfamily
DXY22_00366	COG4895	conserved protein (DUF2196)
DXY22_00367	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DXY22_00368	COG0346	lactoylglutathione lyase activity
DXY22_00370	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DXY22_00371	COG1404	Belongs to the peptidase S8 family
DXY22_00372	COG1263	PTS System
DXY22_00372	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY22_00373	COG3711	transcriptional antiterminator
DXY22_00374	COG1442	glycosyl transferase family 8
DXY22_00375	COG5522	Integral membrane protein (intg_mem_TP0381)
DXY22_00376	COG1846	Transcriptional regulator
DXY22_00377	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DXY22_00378	COG2234	aminopeptidase activity
DXY22_00381	COG2814	Major facilitator Superfamily
DXY22_00382	COG2357	RelA SpoT domain protein
DXY22_00383	COG1575	Belongs to the MenA family. Type 1 subfamily
DXY22_00385	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_00386	COG1696	Membrane protein involved in D-alanine export
DXY22_00387	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DXY22_00388	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
DXY22_00389	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
DXY22_00390	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DXY22_00391	COG1486	melibiose metabolic process
DXY22_00392	COG1447	Phosphotransferase system cellobiose-specific component IIA
DXY22_00393	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DXY22_00394	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DXY22_00395	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DXY22_00395	COG3711	transcriptional antiterminator
DXY22_00397	COG2094	Belongs to the DNA glycosylase MPG family
DXY22_00398	COG0753	catalase activity
DXY22_00399	COG2814	Major facilitator Superfamily
DXY22_00400	COG2814	Major facilitator Superfamily
DXY22_00401	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DXY22_00402	COG1131	(ABC) transporter
DXY22_00406	COG1595	DNA-templated transcription, initiation
DXY22_00407	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DXY22_00408	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DXY22_00409	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
DXY22_00410	COG4988	ABC transporter
DXY22_00411	COG1294	oxidase, subunit
DXY22_00412	COG1271	oxidase subunit
DXY22_00413	COG3493	citrate carrier protein
DXY22_00414	COG0501	Belongs to the peptidase M48B family
DXY22_00416	COG0726	polysaccharide deacetylase
DXY22_00417	COG3842	ATPase activity
DXY22_00418	COG2508	Transcriptional regulator
DXY22_00419	COG1012	belongs to the aldehyde dehydrogenase family
DXY22_00420	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DXY22_00422	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DXY22_00424	COG4585	Histidine kinase
DXY22_00425	COG2197	response regulator
DXY22_00426	COG2195	Cleaves the N-terminal amino acid of tripeptides
DXY22_00428	COG4894	glucomannan catabolic process
DXY22_00429	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DXY22_00430	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DXY22_00431	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_00432	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DXY22_00433	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DXY22_00434	COG2610	gluconate transmembrane transporter activity
DXY22_00435	COG0500	methyltransferase
DXY22_00436	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DXY22_00439	COG0693	protein deglycase activity
DXY22_00439	COG0753	catalase activity
DXY22_00440	COG2851	Citrate transporter
DXY22_00441	COG2273	Hydrolase Family 16
DXY22_00442	COG3711	transcriptional antiterminator
DXY22_00444	COG2270	Major facilitator Superfamily
DXY22_00445	COG0513	Belongs to the DEAD box helicase family
DXY22_00446	COG3401	FG-GAP repeat protein
DXY22_00446	COG2755	lipolytic protein G-D-S-L family
DXY22_00459	COG0697	spore germination
DXY22_00460	COG0589	response to stress
DXY22_00461	COG2723	6-phospho-beta-galactosidase activity
DXY22_00462	COG2190	(PTS) system
DXY22_00462	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY22_00462	COG1263	PTS System
DXY22_00464	COG5444	nuclease activity
DXY22_00467	COG3507	Belongs to the glycosyl hydrolase 43 family
DXY22_00469	COG2986	histidine ammonia-lyase
DXY22_00470	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DXY22_00471	COG1228	amidohydrolase
DXY22_00472	COG0010	Belongs to the arginase family
DXY22_00473	COG0833	amino acid
DXY22_00474	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
DXY22_00475	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DXY22_00476	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
DXY22_00477	COG2390	Transcriptional regulator
DXY22_00479	COG3192	ethanolamine utilization protein
DXY22_00480	COG2079	MmgE PrpD family protein
DXY22_00481	COG1473	amidohydrolase
DXY22_00482	COG1126	abc transporter atp-binding protein
DXY22_00483	COG0765	amino acid transport
DXY22_00484	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DXY22_00485	COG0456	acetyltransferase
DXY22_00486	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DXY22_00487	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DXY22_00488	COG0561	phosphatase activity
DXY22_00494	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DXY22_00495	COG5294	Protein conserved in bacteria
DXY22_00496	COG0577	efflux transmembrane transporter activity
DXY22_00497	COG1136	(ABC) transporter
DXY22_00498	COG2205	protein histidine kinase activity
DXY22_00499	COG0745	RESPONSE REGULATOR receiver
DXY22_00500	COG0191	fructose-bisphosphate aldolase activity
DXY22_00501	COG1082	Xylose isomerase domain protein TIM barrel
DXY22_00502	COG1082	Xylose isomerase domain protein TIM barrel
DXY22_00503	COG0673	inositol 2-dehydrogenase activity
DXY22_00504	COG2814	Major facilitator Superfamily
DXY22_00505	COG1082	Xylose isomerase domain protein TIM barrel
DXY22_00506	COG3962	Belongs to the TPP enzyme family
DXY22_00507	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DXY22_00509	COG1012	belongs to the aldehyde dehydrogenase family
DXY22_00510	COG1349	DNA-binding transcription factor activity
DXY22_00511	COG0667	Aldo Keto reductase
DXY22_00514	COG2814	Major facilitator Superfamily
DXY22_00515	COG0326	Molecular chaperone. Has ATPase activity
DXY22_00517	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_00518	COG1309	transcriptional regulator
DXY22_00519	COG1012	belongs to the aldehyde dehydrogenase family
DXY22_00520	COG0456	acetyltransferase
DXY22_00521	COG2850	peptidyl-arginine hydroxylation
DXY22_00522	COG2226	methyltransferase
DXY22_00525	COG0367	asparagine synthase
DXY22_00526	COG2814	Major facilitator Superfamily
DXY22_00527	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DXY22_00529	COG1714	RDD family
DXY22_00530	COG2311	Membrane
DXY22_00531	COG1917	Cupin 2, conserved barrel domain protein
DXY22_00532	COG1309	transcriptional regulator
DXY22_00533	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_00534	COG1846	Transcriptional regulator
DXY22_00535	COG1380	Effector of murein hydrolase LrgA
DXY22_00536	COG1346	cytolysis
DXY22_00537	COG5039	Polysaccharide pyruvyl transferase
DXY22_00538	COG1929	Belongs to the glycerate kinase type-1 family
DXY22_00539	COG1802	Transcriptional regulator
DXY22_00540	COG1070	Carbohydrate kinase
DXY22_00541	COG2610	gluconate transmembrane transporter activity
DXY22_00542	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DXY22_00543	COG0450	alkyl hydroperoxide reductase
DXY22_00544	COG3634	alkyl hydroperoxide reductase activity
DXY22_00546	COG2723	6-phospho-beta-galactosidase activity
DXY22_00547	COG1263	PTS System
DXY22_00547	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY22_00547	COG2190	(PTS) system
DXY22_00548	COG2188	Transcriptional regulator
DXY22_00550	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
DXY22_00556	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DXY22_00559	COG1063	alcohol dehydrogenase
DXY22_00563	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
DXY22_00564	COG0456	acetyltransferase
DXY22_00565	COG0457	Tetratricopeptide repeat
DXY22_00567	COG0010	Belongs to the arginase family
DXY22_00568	COG0833	amino acid
DXY22_00569	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DXY22_00570	COG3829	transcription factor binding
DXY22_00571	COG5002	protein histidine kinase activity
DXY22_00575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DXY22_00576	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DXY22_00577	COG4853	Protein conserved in bacteria
DXY22_00578	COG4863	YycH protein
DXY22_00579	COG5002	protein histidine kinase activity
DXY22_00580	COG0745	RESPONSE REGULATOR receiver
DXY22_00586	COG0346	lactoylglutathione lyase activity
DXY22_00587	COG0305	Participates in initiation and elongation during chromosome replication
DXY22_00590	COG3093	addiction module antidote protein HigA
DXY22_00591	COG2807	transmembrane transport
DXY22_00592	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DXY22_00593	COG0359	binds to the 23S rRNA
DXY22_00594	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
DXY22_00595	COG4241	membrane
DXY22_00597	COG5577	PFAM Coat F domain
DXY22_00598	COG1733	regulation of RNA biosynthetic process
DXY22_00599	COG1227	inorganic diphosphatase activity
DXY22_00602	COG2271	Major facilitator Superfamily
DXY22_00603	COG4978	Transcriptional regulator
DXY22_00603	COG0789	Transcriptional regulator
DXY22_00605	COG4319	ketosteroid isomerase
DXY22_00606	COG1357	PFAM Pentapeptide repeats (8 copies)
DXY22_00607	COG2814	Major facilitator Superfamily
DXY22_00608	COG0583	DNA-binding transcription factor activity
DXY22_00609	COG2153	protein acetylation
DXY22_00611	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DXY22_00612	COG1846	Transcriptional regulator
DXY22_00613	COG2153	protein acetylation
DXY22_00614	COG2364	Membrane
DXY22_00615	COG0456	acetyltransferase
DXY22_00616	COG2315	Protein conserved in bacteria
DXY22_00617	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DXY22_00618	COG2814	Major facilitator Superfamily
DXY22_00619	COG1331	Highly conserved protein containing a thioredoxin domain
DXY22_00622	COG0789	Transcriptional regulator
DXY22_00623	COG0697	spore germination
DXY22_00624	COG1331	Highly conserved protein containing a thioredoxin domain
DXY22_00625	COG1266	CAAX protease self-immunity
DXY22_00626	COG0477	Major facilitator Superfamily
DXY22_00626	COG2814	Major facilitator Superfamily
DXY22_00627	COG0110	maltose O-acetyltransferase activity
DXY22_00628	COG0346	lactoylglutathione lyase activity
DXY22_00629	COG1609	Transcriptional regulator
DXY22_00630	COG0708	Exodeoxyribonuclease III
DXY22_00631	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DXY22_00632	COG0629	single-stranded DNA binding
DXY22_00633	COG0360	Binds together with S18 to 16S ribosomal RNA
DXY22_00634	COG0012	GTP binding
DXY22_00635	COG0243	molybdopterin cofactor binding
DXY22_00636	COG4481	Protein conserved in bacteria
DXY22_00637	COG3949	Membrane
DXY22_00639	COG1475	DNA binding
DXY22_00640	COG1192	Involved in chromosome partitioning
DXY22_00642	COG1475	DNA binding
DXY22_00643	COG0357	Ribosomal RNA small subunit methyltransferase G
DXY22_00644	COG0445	tRNA wobble uridine modification
DXY22_00645	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DXY22_00646	COG1847	R3H domain protein
DXY22_00647	COG0706	membrane insertase activity
DXY22_00648	COG0594	ribonuclease P activity
DXY22_00649	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DXY22_00650	COG0592	DNA-directed DNA polymerase activity
DXY22_00651	COG2501	S4 domain
DXY22_00652	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
DXY22_00654	COG0187	DNA topoisomerase II activity
DXY22_00655	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DXY22_00662	COG0516	GMP reductase activity
DXY22_00662	COG0517	IMP dehydrogenase activity
DXY22_00663	COG1686	Belongs to the peptidase S11 family
DXY22_00664	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
DXY22_00665	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
DXY22_00666	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DXY22_00668	COG1428	Deoxynucleoside kinase
DXY22_00669	COG1428	Deoxynucleoside kinase
DXY22_00670	COG3858	chitin binding
DXY22_00670	COG1388	LysM domain
DXY22_00671	COG1335	isochorismatase
DXY22_00672	COG0590	tRNA wobble adenosine to inosine editing
DXY22_00673	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DXY22_00674	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DXY22_00675	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
DXY22_00684	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
DXY22_00685	COG3853	Toxic anion resistance protein (TelA)
DXY22_00686	COG1982	Orn Lys Arg decarboxylase major
DXY22_00687	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DXY22_00688	COG3870	Protein conserved in bacteria
DXY22_00689	COG1728	Protein conserved in bacteria
DXY22_00690	COG0470	DNA polymerase III
DXY22_00691	COG1774	PSP1 C-terminal conserved region
DXY22_00692	COG4467	Involved in initiation control of chromosome replication
DXY22_00693	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DXY22_00694	COG2827	Endonuclease containing a URI domain
DXY22_00695	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DXY22_00696	COG2002	toxin-antitoxin pair type II binding
DXY22_00697	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DXY22_00697	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DXY22_00698	COG0084	hydrolase, TatD family'
DXY22_00699	COG3583	domain protein
DXY22_00699	COG3584	3D domain protein
DXY22_00700	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DXY22_00701	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DXY22_00703	COG4466	Protein conserved in bacteria
DXY22_00704	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DXY22_00705	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DXY22_00706	COG0251	oxidation-reduction process
DXY22_00707	COG2088	sporulation resulting in formation of a cellular spore
DXY22_00708	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DXY22_00709	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DXY22_00710	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
DXY22_00711	COG0193	aminoacyl-tRNA hydrolase activity
DXY22_00713	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DXY22_00714	COG2002	toxin-antitoxin pair type II binding
DXY22_00715	COG2244	polysaccharide biosynthetic process
DXY22_00716	COG3956	TIGRFAM MazG family protein
DXY22_00717	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DXY22_00720	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DXY22_00721	COG1098	S1 RNA binding domain
DXY22_00724	COG2208	phosphoserine phosphatase activity
DXY22_00725	COG2304	oxidoreductase activity
DXY22_00726	COG0515	serine threonine protein kinase
DXY22_00727	COG0037	tRNA processing
DXY22_00729	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DXY22_00730	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DXY22_00731	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DXY22_00732	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DXY22_00733	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DXY22_00734	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DXY22_00735	COG0512	Glutamine amidotransferase of anthranilate synthase
DXY22_00736	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DXY22_00737	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DXY22_00738	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
DXY22_00739	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DXY22_00740	COG1396	sequence-specific DNA binding
DXY22_00741	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DXY22_00742	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DXY22_00758	COG4463	regulation of RNA biosynthetic process
DXY22_00759	COG3880	PFAM UvrB UvrC protein
DXY22_00760	COG3869	Catalyzes the specific phosphorylation of arginine residues in
DXY22_00761	COG0542	response to heat
DXY22_00762	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DXY22_00763	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
DXY22_00764	COG4956	integral membrane protein (PIN domain superfamily)
DXY22_00765	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DXY22_00766	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
DXY22_00767	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DXY22_00768	COG1045	serine acetyltransferase
DXY22_00769	COG0215	cysteine-tRNA ligase activity
DXY22_00770	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
DXY22_00771	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DXY22_00772	COG3688	RNA-binding protein containing a PIN domain
DXY22_00773	COG1595	DNA-templated transcription, initiation
DXY22_00774	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DXY22_00775	COG0250	Participates in transcription elongation, termination and antitermination
DXY22_00777	COG0081	regulation of translation
DXY22_00778	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DXY22_00780	COG2813	Specifically methylates the guanine in position
DXY22_00781	COG0085	RNA polymerase activity
DXY22_00782	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DXY22_00783	COG1358	cellular component organization or biogenesis
DXY22_00784	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DXY22_00785	COG0049	tRNA binding
DXY22_00786	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
DXY22_00787	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DXY22_00788	COG0596	Alpha beta hydrolase
DXY22_00790	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DXY22_00791	COG0088	Forms part of the polypeptide exit tunnel
DXY22_00793	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
DXY22_00797	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DXY22_00799	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DXY22_00800	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DXY22_00802	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DXY22_00804	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DXY22_00805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DXY22_00806	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DXY22_00809	COG0200	Binds to the 23S rRNA
DXY22_00810	COG0201	protein transport
DXY22_00811	COG0563	adenylate kinase activity
DXY22_00812	COG0024	Methionine aminopeptidase
DXY22_00814	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DXY22_00815	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DXY22_00816	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DXY22_00817	COG0202	RNA polymerase activity
DXY22_00818	COG0203	ribosomal protein L17
DXY22_00819	COG1122	ATPase activity
DXY22_00820	COG1122	ATPase activity
DXY22_00821	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DXY22_00822	COG0101	tRNA pseudouridine synthase activity
DXY22_00823	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DXY22_00824	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DXY22_00825	COG2226	methyltransferase
DXY22_00827	COG0860	N-Acetylmuramoyl-L-alanine amidase
DXY22_00828	COG0489	protein tyrosine kinase activity
DXY22_00830	COG2194	sulfuric ester hydrolase activity
DXY22_00831	COG0726	polysaccharide deacetylase
DXY22_00844	COG0659	secondary active sulfate transmembrane transporter activity
DXY22_00846	COG0385	Bile acid
DXY22_00847	COG2819	hydrolase of the alpha beta superfamily
DXY22_00848	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY22_00849	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY22_00850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DXY22_00851	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DXY22_00851	COG2207	Transcriptional regulator
DXY22_00852	COG3876	Protein conserved in bacteria
DXY22_00853	COG1472	Belongs to the glycosyl hydrolase 3 family
DXY22_00854	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DXY22_00855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY22_00855	COG1263	PTS System
DXY22_00856	COG1737	Transcriptional regulator
DXY22_00857	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
DXY22_00858	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DXY22_00859	COG1683	Conserved Protein
DXY22_00865	COG1595	DNA-templated transcription, initiation
DXY22_00866	COG5662	AntiSigma factor
DXY22_00867	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DXY22_00868	COG4856	YbbR-like protein
DXY22_00869	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DXY22_00870	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DXY22_00871	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DXY22_00872	COG2169	Transcriptional regulator
DXY22_00873	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DXY22_00874	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DXY22_00875	COG3002	Belongs to the UPF0753 family
DXY22_00876	COG0288	reversible hydration of carbon dioxide
DXY22_00879	COG5609	conserved protein (DUF2294)
DXY22_00880	COG0640	Transcriptional regulator
DXY22_00881	COG2814	Major facilitator Superfamily
DXY22_00883	COG0535	radical SAM domain protein
DXY22_00884	COG1266	CAAX protease self-immunity
DXY22_00885	COG1131	(ABC) transporter
DXY22_00887	COG1413	lyase activity
DXY22_00888	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY22_00889	COG0596	Alpha beta hydrolase
DXY22_00890	COG0745	RESPONSE REGULATOR receiver
DXY22_00891	COG0642	Histidine kinase
DXY22_00893	COG0515	serine threonine protein kinase
DXY22_00896	COG1113	amino acid transport
DXY22_00899	COG2602	Beta-lactamase
DXY22_00900	COG2124	cytochrome p450
DXY22_00902	COG0531	amino acid
DXY22_00903	COG0584	glycerophosphoryl diester phosphodiesterase
DXY22_00904	COG2271	Major facilitator Superfamily
DXY22_00906	COG0456	acetyltransferase
DXY22_00906	COG1846	Transcriptional regulator
DXY22_00907	COG2271	Major facilitator Superfamily
DXY22_00909	COG3409	Peptidoglycan-binding domain 1 protein
DXY22_00910	COG0697	spore germination
DXY22_00911	COG2207	Transcriptional regulator
DXY22_00911	COG1917	Cupin 2, conserved barrel domain protein
DXY22_00912	COG1397	ADP-ribosylglycohydrolase
DXY22_00913	COG5444	nuclease activity
DXY22_00914	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
DXY22_00915	COG3591	Belongs to the peptidase S1B family
DXY22_00917	COG0596	Alpha beta hydrolase
DXY22_00918	COG1183	phosphatidylcholine synthase activity
DXY22_00919	COG0586	Pfam SNARE associated Golgi protein
DXY22_00920	COG0688	phosphatidylethanolamine metabolic process
DXY22_00922	COG2312	Erythromycin esterase
DXY22_00924	COG1301	dicarboxylic acid transport
DXY22_00925	COG1263	PTS System
DXY22_00925	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY22_00925	COG2190	(PTS) system
DXY22_00926	COG0363	glucosamine-6-phosphate deaminase activity
DXY22_00927	COG2188	Transcriptional regulator
DXY22_00929	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DXY22_00930	COG0833	amino acid
DXY22_00931	COG2040	homocysteine
DXY22_00932	COG1115	amino acid carrier protein
DXY22_00933	COG2066	Belongs to the glutaminase family
DXY22_00934	COG4191	Histidine kinase
DXY22_00935	COG0784	Response regulator, receiver
DXY22_00936	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DXY22_00937	COG1012	belongs to the aldehyde dehydrogenase family
DXY22_00938	COG2271	Major facilitator Superfamily
DXY22_00939	COG4948	Mandelate Racemase Muconate Lactonizing
DXY22_00940	COG2186	Transcriptional regulator
DXY22_00941	COG2721	sulfolactate sulfo-lyase activity
DXY22_00942	COG3173	Aminoglycoside phosphotransferase
DXY22_00944	COG0697	spore germination
DXY22_00945	COG0745	RESPONSE REGULATOR receiver
DXY22_00946	COG2205	protein histidine kinase activity
DXY22_00947	COG1131	(ABC) transporter
DXY22_00950	COG3773	Cell wall hydrolase
DXY22_00951	COG2304	oxidoreductase activity
DXY22_00952	COG3540	Alkaline phosphatase
DXY22_00953	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DXY22_00954	COG0805	protein transport
DXY22_00955	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
DXY22_00956	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DXY22_00957	COG0477	Major facilitator Superfamily
DXY22_00958	COG1309	transcriptional regulator
DXY22_00959	COG0252	asparaginase activity
DXY22_00960	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DXY22_00961	COG1714	RDD family
DXY22_00962	COG3012	SEC-C Motif Domain Protein
DXY22_00962	COG1405	negative regulation of cell septum assembly
DXY22_00963	COG3290	protein histidine kinase activity
DXY22_00964	COG3279	Response regulator of the LytR AlgR family
DXY22_00965	COG4555	ABC transporter
DXY22_00966	COG1668	transmembrane transport
DXY22_00967	COG0667	Aldo Keto reductase
DXY22_00969	COG1595	DNA-templated transcription, initiation
DXY22_00970	COG1595	DNA-templated transcription, initiation
DXY22_00971	COG1876	peptidase activity
DXY22_00972	COG0457	Tetratricopeptide repeat
DXY22_00973	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_00974	COG0366	Alpha amylase catalytic
DXY22_00975	COG0803	Belongs to the bacterial solute-binding protein 9 family
DXY22_00976	COG1121	(ABC) transporter
DXY22_00977	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DXY22_00978	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DXY22_00979	COG2310	stress, protein
DXY22_00980	COG2310	stress, protein
DXY22_00981	COG2310	stress, protein
DXY22_00982	COG0861	Integral membrane protein TerC family
DXY22_00984	COG3853	Toxic anion resistance protein (TelA)
DXY22_00985	COG0477	Major facilitator Superfamily
DXY22_00986	COG2814	Major facilitator Superfamily
DXY22_00987	COG0640	Transcriptional regulator
DXY22_00988	COG4175	Glycine betaine
DXY22_00988	COG0517	IMP dehydrogenase activity
DXY22_00989	COG4176	ABC-type proline glycine betaine transport system permease component
DXY22_00990	COG2113	Glycine betaine
DXY22_00991	COG1473	amidohydrolase
DXY22_00992	COG1288	antiporter activity
DXY22_00994	COG0366	Alpha amylase catalytic
DXY22_00995	COG0039	L-malate dehydrogenase activity
DXY22_00996	COG1620	l-lactate permease
DXY22_00997	COG2814	Major facilitator Superfamily
DXY22_00998	COG1846	Transcriptional regulator
DXY22_00999	COG1280	lysine exporter protein (LysE YggA)
DXY22_01000	COG3403	YqcI/YcgG family
DXY22_01001	COG1113	amino acid transport
DXY22_01002	COG3665	Urea carboxylase-associated protein
DXY22_01003	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DXY22_01004	COG1660	Displays ATPase and GTPase activities
DXY22_01006	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DXY22_01007	COG2226	methyltransferase
DXY22_01008	COG0583	DNA-binding transcription factor activity
DXY22_01009	COG3458	cephalosporin-C deacetylase activity
DXY22_01010	COG3541	Predicted nucleotidyltransferase
DXY22_01011	COG0506	proline dehydrogenase activity
DXY22_01012	COG1012	belongs to the aldehyde dehydrogenase family
DXY22_01013	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DXY22_01014	COG2508	Transcriptional regulator
DXY22_01015	COG3689	TIGRFAM TIGR03943 family protein
DXY22_01016	COG0701	Predicted permease
DXY22_01017	COG2267	carboxylic ester hydrolase activity
DXY22_01018	COG0492	ferredoxin-NADP+ reductase activity
DXY22_01019	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DXY22_01019	COG1587	Uroporphyrinogen-III synthase
DXY22_01020	COG2146	nitrite reductase [NAD(P)H] activity
DXY22_01021	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DXY22_01022	COG0243	molybdopterin cofactor binding
DXY22_01023	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DXY22_01024	COG2223	nitrite transmembrane transporter activity
DXY22_01025	COG1469	GTP cyclohydrolase I activity
DXY22_01026	COG1376	ErfK ybiS ycfS ynhG family protein
DXY22_01027	COG0523	cobalamin synthesis protein
DXY22_01028	COG0765	amino acid transport
DXY22_01029	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DXY22_01031	COG1846	Transcriptional regulator
DXY22_01035	COG2723	6-phospho-beta-galactosidase activity
DXY22_01037	COG3209	COG3209 Rhs family protein
DXY22_01038	COG0840	transmembrane signaling receptor activity
DXY22_01038	COG3290	protein histidine kinase activity
DXY22_01039	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DXY22_01040	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
DXY22_01041	COG1733	regulation of RNA biosynthetic process
DXY22_01042	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_01043	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_01044	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_01045	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
DXY22_01046	COG2814	Major facilitator Superfamily
DXY22_01048	COG0697	spore germination
DXY22_01049	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DXY22_01051	COG2364	Membrane
DXY22_01052	COG1126	abc transporter atp-binding protein
DXY22_01053	COG0765	amino acid transport
DXY22_01054	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DXY22_01055	COG0583	DNA-binding transcription factor activity
DXY22_01056	COG0163	prenyltransferase activity
DXY22_01057	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DXY22_01060	COG0596	Alpha beta hydrolase
DXY22_01061	COG3104	oligopeptide transport
DXY22_01062	COG5434	Belongs to the glycosyl hydrolase 28 family
DXY22_01064	COG0697	spore germination
DXY22_01066	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DXY22_01067	COG1136	(ABC) transporter
DXY22_01068	COG0577	efflux transmembrane transporter activity
DXY22_01069	COG0745	RESPONSE REGULATOR receiver
DXY22_01070	COG3850	Histidine kinase
DXY22_01070	COG5002	protein histidine kinase activity
DXY22_01071	COG0457	Tetratricopeptide repeat
DXY22_01075	COG0527	aspartate kinase activity
DXY22_01076	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY22_01077	COG4605	iron ion homeostasis
DXY22_01078	COG4604	ABC transporter, ATP-binding protein
DXY22_01079	COG4607	ABC-type enterochelin transport system periplasmic component
DXY22_01080	COG2814	Major facilitator Superfamily
DXY22_01081	COG1309	transcriptional regulator
DXY22_01082	COG0778	Nitroreductase
DXY22_01083	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DXY22_01084	COG0640	Transcriptional regulator
DXY22_01085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DXY22_01086	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
DXY22_01087	COG1012	belongs to the aldehyde dehydrogenase family
DXY22_01088	COG4975	Glucose uptake
DXY22_01089	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_01090	COG4549	nuclear export factor GLE1
DXY22_01091	COG2372	response to copper ion
DXY22_01091	COG1276	copper resistance
DXY22_01092	COG1349	DNA-binding transcription factor activity
DXY22_01094	COG2213	PTS system mannitol-specific
DXY22_01095	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DXY22_01096	COG0246	Mannitol dehydrogenase
DXY22_01097	COG0473	3-isopropylmalate dehydrogenase activity
DXY22_01098	COG0681	Belongs to the peptidase S26 family
DXY22_01099	COG0412	Dienelactone hydrolase
DXY22_01100	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DXY22_01102	COG0561	phosphatase activity
DXY22_01103	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DXY22_01104	COG1914	H( )-stimulated, divalent metal cation uptake system
DXY22_01105	COG4336	lyase activity
DXY22_01106	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DXY22_01107	COG1984	allophanate hydrolase subunit 2
DXY22_01108	COG1414	Transcriptional regulator
DXY22_01109	COG2755	lipolytic protein G-D-S-L family
DXY22_01111	COG2329	Antibiotic biosynthesis monooxygenase
DXY22_01112	COG0768	penicillin binding
DXY22_01113	COG4989	oxidoreductase activity
DXY22_01114	COG3711	transcriptional antiterminator
DXY22_01115	COG0318	PFAM AMP-dependent synthetase and ligase
DXY22_01116	COG2226	methyltransferase
DXY22_01117	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_01118	COG1917	Cupin 2, conserved barrel domain protein
DXY22_01119	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DXY22_01120	COG3871	stress protein (general stress protein 26)
DXY22_01122	COG2814	Major facilitator Superfamily
DXY22_01123	COG1522	sequence-specific DNA binding
DXY22_01124	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DXY22_01124	COG0551	DNA topoisomerase type I activity
DXY22_01125	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DXY22_01126	COG3706	GGDEF domain
DXY22_01127	COG5298	Protein conserved in bacteria
DXY22_01128	COG1215	transferase activity, transferring glycosyl groups
DXY22_01130	COG0531	amino acid
DXY22_01131	COG0494	nUDIX hydrolase
DXY22_01132	COG0028	Belongs to the TPP enzyme family
DXY22_01134	COG1914	H( )-stimulated, divalent metal cation uptake system
DXY22_01135	COG2261	transglycosylase associated protein
DXY22_01136	COG4876	unkown
DXY22_01137	COG2217	Heavy metal translocating P-type atpase
DXY22_01138	COG3729	General stress protein
DXY22_01139	COG0662	Cupin 2, conserved barrel domain protein
DXY22_01140	COG2329	Antibiotic biosynthesis monooxygenase
DXY22_01141	COG3546	catalase activity
DXY22_01142	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
DXY22_01143	COG3290	protein histidine kinase activity
DXY22_01144	COG4565	transcriptional regulatory protein
DXY22_01145	COG1301	dicarboxylic acid transport
DXY22_01146	COG0628	permease
DXY22_01147	COG1131	(ABC) transporter
DXY22_01148	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DXY22_01150	COG1960	acyl-CoA dehydrogenase activity
DXY22_01153	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DXY22_01154	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY22_01155	COG1181	Belongs to the D-alanine--D-alanine ligase family
DXY22_01156	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DXY22_01157	COG0513	Belongs to the DEAD box helicase family
DXY22_01158	COG3402	PFAM membrane-flanked domain
DXY22_01159	COG3428	Bacterial PH domain
DXY22_01160	COG0705	Rhomboid family
DXY22_01161	COG0736	holo-[acyl-carrier-protein] synthase activity
DXY22_01162	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DXY22_01163	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DXY22_01164	COG0864	Transcriptional regulator
DXY22_01165	COG2337	Toxic component of a toxin-antitoxin (TA) module
DXY22_01166	COG1366	Belongs to the anti-sigma-factor antagonist family
DXY22_01167	COG1366	Belongs to the anti-sigma-factor antagonist family
DXY22_01168	COG2172	sigma factor antagonist activity
DXY22_01169	COG2208	phosphoserine phosphatase activity
DXY22_01170	COG1366	Belongs to the anti-sigma-factor antagonist family
DXY22_01171	COG2172	sigma factor antagonist activity
DXY22_01172	COG1191	sigma factor activity
DXY22_01173	COG2208	phosphoserine phosphatase activity
DXY22_01174	COG2183	response to ionizing radiation
DXY22_01175	COG3091	SprT-like family
DXY22_01183	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DXY22_01193	COG1476	TRANSCRIPTIONal
DXY22_01198	COG0693	protein deglycase activity
DXY22_01199	COG1278	Cold shock
DXY22_01200	COG1329	Transcriptional regulator
DXY22_01201	COG0697	spore germination
DXY22_01202	COG1917	Cupin 2, conserved barrel domain protein
DXY22_01202	COG2207	Transcriptional regulator
DXY22_01203	COG0697	spore germination
DXY22_01204	COG3708	Transcriptional regulator
DXY22_01204	COG2207	Transcriptional regulator
DXY22_01205	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DXY22_01206	COG0477	Major facilitator Superfamily
DXY22_01208	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
DXY22_01211	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DXY22_01212	COG1309	transcriptional regulator
DXY22_01213	COG0697	spore germination
DXY22_01214	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DXY22_01215	COG2030	dehydratase
DXY22_01216	COG3545	Serine hydrolase
DXY22_01217	COG1733	regulation of RNA biosynthetic process
DXY22_01218	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DXY22_01219	COG1733	regulation of RNA biosynthetic process
DXY22_01220	COG2249	NAD(P)H dehydrogenase (quinone) activity
DXY22_01221	COG2814	Major facilitator Superfamily
DXY22_01222	COG1309	transcriptional regulator
DXY22_01223	COG0640	Transcriptional regulator
DXY22_01224	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DXY22_01225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DXY22_01226	COG0697	spore germination
DXY22_01227	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DXY22_01228	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DXY22_01229	COG0640	Transcriptional regulator
DXY22_01230	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DXY22_01232	COG4585	Histidine kinase
DXY22_01233	COG2197	response regulator
DXY22_01234	COG2409	Drug exporters of the RND superfamily
DXY22_01235	COG0596	Alpha beta hydrolase
DXY22_01236	COG1811	Na channel or pump
DXY22_01237	COG4978	Transcriptional regulator
DXY22_01237	COG0789	Transcriptional regulator
DXY22_01238	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DXY22_01239	COG0778	Nitroreductase
DXY22_01240	COG0346	lactoylglutathione lyase activity
DXY22_01241	COG2259	Doxx family
DXY22_01242	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY22_01246	COG2323	membrane
DXY22_01247	COG2323	membrane
DXY22_01248	COG0071	Belongs to the small heat shock protein (HSP20) family
DXY22_01251	COG1309	transcriptional regulator
DXY22_01253	COG0456	acetyltransferase
DXY22_01255	COG1113	amino acid transport
DXY22_01256	COG2318	DinB family
DXY22_01257	COG1846	Transcriptional regulator
DXY22_01258	COG2409	Drug exporters of the RND superfamily
DXY22_01258	COG1033	growth of symbiont in host cell
DXY22_01259	COG0778	Nitroreductase
DXY22_01260	COG1846	Transcriptional regulator
DXY22_01261	COG2814	Major facilitator Superfamily
DXY22_01262	COG0730	response to heat
DXY22_01263	COG1802	Transcriptional regulator
DXY22_01264	COG1388	LysM domain
DXY22_01264	COG3858	chitin binding
DXY22_01265	COG1819	glycosyl
DXY22_01267	COG1785	Belongs to the alkaline phosphatase family
DXY22_01268	COG5646	InterPro IPR014922
DXY22_01270	COG0454	-acetyltransferase
DXY22_01271	COG1078	dGTPase activity
DXY22_01272	COG1388	LysM domain
DXY22_01273	COG2814	Major facilitator Superfamily
DXY22_01274	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DXY22_01275	COG1447	Phosphotransferase system cellobiose-specific component IIA
DXY22_01276	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
DXY22_01277	COG2723	6-phospho-beta-galactosidase activity
DXY22_01278	COG2188	Transcriptional regulator
DXY22_01279	COG1940	carbohydrate kinase activity
DXY22_01280	COG1482	cell wall glycoprotein biosynthetic process
DXY22_01281	COG4124	Belongs to the glycosyl hydrolase 26 family
DXY22_01290	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DXY22_01291	COG0802	atpase or kinase
DXY22_01292	COG1214	PFAM Peptidase M22, glycoprotease
DXY22_01293	COG0456	acetyltransferase
DXY22_01294	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
DXY22_01295	COG0488	(ABC) transporter
DXY22_01296	COG0315	cyclic pyranopterin monophosphate synthase activity
DXY22_01297	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
DXY22_01298	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DXY22_01299	COG0805	protein transport
DXY22_01301	COG1266	CAAX protease self-immunity
DXY22_01303	COG0459	protein refolding
DXY22_01304	COG1073	alpha beta
DXY22_01305	COG0457	Tetratricopeptide repeat
DXY22_01306	COG1063	alcohol dehydrogenase
DXY22_01307	COG2211	Major facilitator Superfamily
DXY22_01308	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DXY22_01309	COG1842	Phage shock protein A
DXY22_01310	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DXY22_01311	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
DXY22_01312	COG4260	virion core protein, lumpy skin disease virus
DXY22_01314	COG2814	Major facilitator Superfamily
DXY22_01315	COG1063	alcohol dehydrogenase
DXY22_01316	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DXY22_01317	COG0823	Involved in the tonB-independent uptake of proteins
DXY22_01320	COG2267	carboxylic ester hydrolase activity
DXY22_01322	COG2132	Multicopper oxidase
DXY22_01323	COG1113	amino acid transport
DXY22_01324	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DXY22_01325	COG0714	Associated with various cellular activities
DXY22_01326	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
DXY22_01327	COG1305	Transglutaminase-like
DXY22_01328	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DXY22_01328	COG0519	Catalyzes the synthesis of GMP from XMP
DXY22_01331	COG2252	PERMEase
DXY22_01332	COG3064	Membrane
DXY22_01334	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
DXY22_01336	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DXY22_01337	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DXY22_01338	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DXY22_01339	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DXY22_01340	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DXY22_01341	COG0047	phosphoribosylformylglycinamidine synthase activity
DXY22_01342	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DXY22_01343	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DXY22_01344	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DXY22_01345	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DXY22_01346	COG0138	bifunctional purine biosynthesis protein purh
DXY22_01347	COG0151	Belongs to the GarS family
DXY22_01348	COG1522	sequence-specific DNA binding
DXY22_01349	COG0531	amino acid
DXY22_01351	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DXY22_01352	COG1470	cell adhesion involved in biofilm formation
DXY22_01353	COG4496	protein, YerC YecD
DXY22_01354	COG0069	glutamate synthase activity
DXY22_01355	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
DXY22_01356	COG0210	DNA helicase
DXY22_01357	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DXY22_01358	COG4851	CamS sex pheromone cAM373 precursor
DXY22_01359	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DXY22_01360	COG1285	pathogenesis
DXY22_01361	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DXY22_01362	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DXY22_01363	COG0154	amidase activity
DXY22_01364	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DXY22_01365	COG1309	transcriptional regulator
DXY22_01366	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DXY22_01367	COG1597	lipid kinase activity
DXY22_01368	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DXY22_01370	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
DXY22_01372	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
DXY22_01376	COG5444	nuclease activity
DXY22_01377	COG5444	nuclease activity
DXY22_01378	COG3391	amine dehydrogenase activity
DXY22_01382	COG0457	Tetratricopeptide repeat
DXY22_01384	COG0217	transcriptional regulatory protein
DXY22_01386	COG1309	transcriptional regulator
DXY22_01387	COG3631	Ketosteroid isomerase-related protein
DXY22_01388	COG0702	epimerase
DXY22_01391	COG3546	catalase activity
DXY22_01392	COG0454	-acetyltransferase
DXY22_01393	COG5578	integral membrane protein
DXY22_01394	COG2972	Histidine kinase
DXY22_01395	COG4753	response regulator
DXY22_01395	COG2207	Transcriptional regulator
DXY22_01396	COG1653	transport
DXY22_01397	COG1175	transmembrane transport
DXY22_01398	COG0395	ABC-type sugar transport system, permease component
DXY22_01399	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DXY22_01400	COG2207	Transcriptional regulator
DXY22_01401	COG2755	lipolytic protein G-D-S-L family
DXY22_01403	COG5578	integral membrane protein
DXY22_01404	COG3401	FG-GAP repeat protein
DXY22_01405	COG3401	FG-GAP repeat protein
DXY22_01406	COG2755	lipolytic protein G-D-S-L family
DXY22_01407	COG1874	Beta-galactosidase
DXY22_01409	COG1653	transport
DXY22_01410	COG4209	transmembrane transport
DXY22_01411	COG0395	ABC-type sugar transport system, permease component
DXY22_01412	COG1486	melibiose metabolic process
DXY22_01413	COG2323	membrane
DXY22_01414	COG2329	Antibiotic biosynthesis monooxygenase
DXY22_01415	COG0346	lactoylglutathione lyase activity
DXY22_01418	COG5583	Uncharacterized small protein (DUF2292)
DXY22_01419	COG0670	Belongs to the BI1 family
DXY22_01420	COG1846	Transcriptional regulator
DXY22_01421	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DXY22_01423	COG2124	cytochrome p450
DXY22_01423	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DXY22_01424	COG1368	sulfuric ester hydrolase activity
DXY22_01425	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DXY22_01426	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DXY22_01427	COG1442	glycosyl transferase family 8
DXY22_01428	COG1216	Glycosyl transferase, family 2
DXY22_01429	COG1442	glycosyl transferase family 8
DXY22_01430	COG2223	nitrite transmembrane transporter activity
DXY22_01431	COG1011	Hydrolase
DXY22_01432	COG0531	amino acid
DXY22_01433	COG1012	belongs to the aldehyde dehydrogenase family
DXY22_01434	COG0840	transmembrane signaling receptor activity
DXY22_01435	COG0488	(ABC) transporter
DXY22_01437	COG0789	Transcriptional regulator
DXY22_01438	COG2814	Major facilitator Superfamily
DXY22_01439	COG0488	(ABC) transporter
DXY22_01440	COG0513	Belongs to the DEAD box helicase family
DXY22_01441	COG0456	acetyltransferase
DXY22_01442	COG2130	NADP-dependent
DXY22_01443	COG2211	Major facilitator Superfamily
DXY22_01444	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DXY22_01445	COG1120	ATPase activity
DXY22_01446	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY22_01447	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY22_01448	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DXY22_01451	COG3866	Pectate lyase
DXY22_01452	COG0471	metal ion transport
DXY22_01453	COG3290	protein histidine kinase activity
DXY22_01454	COG4565	transcriptional regulatory protein
DXY22_01455	COG3181	Tripartite tricarboxylate transporter family receptor
DXY22_01456	COG2851	Citrate transporter
DXY22_01457	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DXY22_01458	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
DXY22_01459	COG1254	Belongs to the acylphosphatase family
DXY22_01460	COG2258	MOSC domain
DXY22_01464	COG0024	Methionine aminopeptidase
DXY22_01465	COG1263	PTS System
DXY22_01465	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY22_01466	COG1368	sulfuric ester hydrolase activity
DXY22_01468	COG1115	amino acid carrier protein
DXY22_01469	COG0697	spore germination
DXY22_01470	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY22_01470	COG1263	PTS System
DXY22_01471	COG0366	Alpha amylase catalytic
DXY22_01472	COG2188	Transcriptional regulator
DXY22_01473	COG0778	Nitroreductase
DXY22_01474	COG0737	Belongs to the 5'-nucleotidase family
DXY22_01475	COG0693	protein deglycase activity
DXY22_01476	COG2814	Major facilitator Superfamily
DXY22_01477	COG4840	Belongs to the UPF0435 family
DXY22_01478	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DXY22_01479	COG4980	gas vesicle protein
DXY22_01480	COG1295	ribonuclease BN
DXY22_01481	COG0477	Major facilitator Superfamily
DXY22_01482	COG0387	Pfam Sodium calcium exchanger
DXY22_01484	COG0668	transmembrane transport
DXY22_01485	COG0535	radical SAM domain protein
DXY22_01487	COG0726	polysaccharide deacetylase
DXY22_01488	COG2084	Dehydrogenase
DXY22_01489	COG0598	Magnesium transport protein CorA
DXY22_01490	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
DXY22_01491	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
DXY22_01493	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DXY22_01494	COG4637	Psort location Cytoplasmic, score
DXY22_01496	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DXY22_01497	COG0022	dehydrogenase e1 component
DXY22_01498	COG0508	dehydrogenase complex catalyzes the overall conversion of
DXY22_01499	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DXY22_01500	COG3284	Transcriptional regulator
DXY22_01502	COG1742	UPF0060 membrane protein
DXY22_01506	COG4842	Belongs to the WXG100 family
DXY22_01507	COG1486	melibiose metabolic process
DXY22_01508	COG1737	Transcriptional regulator
DXY22_01509	COG1263	PTS System
DXY22_01509	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY22_01510	COG1132	(ABC) transporter
DXY22_01511	COG1132	(ABC) transporter
DXY22_01512	COG2259	Doxx family
DXY22_01513	COG2514	catechol 2,3-dioxygenase activity
DXY22_01515	COG4585	Histidine kinase
DXY22_01516	COG2197	response regulator
DXY22_01517	COG1131	(ABC) transporter
DXY22_01518	COG0842	Transport permease protein
DXY22_01518	COG1511	domain protein
DXY22_01519	COG0842	Transport permease protein
DXY22_01520	COG1695	Transcriptional regulator
DXY22_01521	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
DXY22_01522	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
DXY22_01523	COG2318	DinB family
DXY22_01524	COG2814	Major facilitator Superfamily
DXY22_01525	COG1846	Transcriptional regulator
DXY22_01526	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
DXY22_01526	COG0392	lysyltransferase activity
DXY22_01527	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DXY22_01528	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY22_01529	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY22_01530	COG0384	phenazine biosynthesis protein PhzF
DXY22_01531	COG0778	Nitroreductase
DXY22_01534	COG1090	epimerase
DXY22_01535	COG2137	regulation of response to DNA damage stimulus
DXY22_01538	COG2814	Major facilitator Superfamily
DXY22_01541	COG3103	Sh3 type 3 domain protein
DXY22_01542	COG5658	integral membrane protein
DXY22_01543	COG0596	Alpha beta hydrolase
DXY22_01544	COG0463	Glycosyl transferase, family 2
DXY22_01545	COG4485	Bacterial membrane protein, YfhO
DXY22_01546	COG1988	membrane-bound metal-dependent
DXY22_01547	COG1194	a g-specific adenine glycosylase
DXY22_01549	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_01552	COG3557	Belongs to the UPF0374 family
DXY22_01553	COG1132	(ABC) transporter
DXY22_01554	COG4129	membrane
DXY22_01555	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DXY22_01556	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DXY22_01557	COG0735	belongs to the Fur family
DXY22_01579	COG4326	sporulation control protein
DXY22_01581	COG3340	Belongs to the peptidase S51 family
DXY22_01582	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DXY22_01583	COG0277	FAD linked oxidase domain protein
DXY22_01585	COG0753	catalase activity
DXY22_01586	COG1116	anion transmembrane transporter activity
DXY22_01587	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DXY22_01588	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DXY22_01589	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DXY22_01591	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DXY22_01593	COG1476	TRANSCRIPTIONal
DXY22_01595	COG3382	B3 4 domain protein
DXY22_01596	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DXY22_01598	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DXY22_01599	COG0789	Transcriptional regulator
DXY22_01600	COG1664	Polymer-forming cytoskeletal
DXY22_01601	COG1664	Polymer-forming cytoskeletal
DXY22_01602	COG2766	serine protein kinase
DXY22_01603	COG2718	Belongs to the UPF0229 family
DXY22_01604	COG1846	Transcriptional regulator
DXY22_01605	COG1566	PFAM secretion protein HlyD family protein
DXY22_01606	COG2814	Major facilitator Superfamily
DXY22_01607	COG0655	NAD(P)H dehydrogenase (quinone) activity
DXY22_01610	COG1725	Transcriptional regulator
DXY22_01611	COG1131	(ABC) transporter
DXY22_01612	COG1131	(ABC) transporter
DXY22_01613	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
DXY22_01614	COG1278	Cold shock
DXY22_01615	COG1464	Belongs to the NlpA lipoprotein family
DXY22_01616	COG3706	GGDEF domain
DXY22_01617	COG1823	symporter activity
DXY22_01621	COG5577	PFAM Coat F domain
DXY22_01622	COG4085	toxin activity
DXY22_01622	COG0737	Belongs to the 5'-nucleotidase family
DXY22_01622	COG1525	nuclease
DXY22_01623	COG3764	Sortase (surface protein transpeptidase)
DXY22_01624	COG0564	pseudouridine synthase activity
DXY22_01626	COG0517	IMP dehydrogenase activity
DXY22_01627	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DXY22_01628	COG3153	acetyltransferase
DXY22_01628	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DXY22_01629	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DXY22_01630	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
DXY22_01631	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DXY22_01632	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
DXY22_01633	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
DXY22_01634	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DXY22_01635	COG2203	Gaf domain
DXY22_01635	COG4585	Histidine kinase
DXY22_01636	COG2197	response regulator
DXY22_01637	COG0431	NADPH-dependent FMN reductase
DXY22_01640	COG1388	LysM domain
DXY22_01640	COG0791	NLP P60 protein
DXY22_01641	COG1959	2 iron, 2 sulfur cluster binding
DXY22_01642	COG0668	transmembrane transport
DXY22_01643	COG2719	SpoVR family
DXY22_01644	COG1785	Belongs to the alkaline phosphatase family
DXY22_01645	COG1388	LysM domain
DXY22_01645	COG0791	NLP P60 protein
DXY22_01646	COG0583	DNA-binding transcription factor activity
DXY22_01647	COG0372	Belongs to the citrate synthase family
DXY22_01648	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_01649	COG0531	amino acid
DXY22_01650	COG0733	neurotransmitter:sodium symporter activity
DXY22_01651	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DXY22_01652	COG0456	acetyltransferase
DXY22_01655	COG1595	DNA-templated transcription, initiation
DXY22_01656	COG0667	Aldo Keto reductase
DXY22_01657	COG0204	Acyl-transferase
DXY22_01658	COG1253	flavin adenine dinucleotide binding
DXY22_01659	COG0789	Transcriptional regulator
DXY22_01660	COG0436	Aminotransferase
DXY22_01661	COG1253	flavin adenine dinucleotide binding
DXY22_01662	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DXY22_01663	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DXY22_01664	COG0584	glycerophosphoryl diester phosphodiesterase
DXY22_01666	COG0668	transmembrane transport
DXY22_01667	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DXY22_01668	COG0726	polysaccharide deacetylase
DXY22_01669	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
DXY22_01670	COG1757	Na H antiporter
DXY22_01671	COG0589	response to stress
DXY22_01672	COG1132	(ABC) transporter
DXY22_01673	COG1132	(ABC) transporter
DXY22_01674	COG0702	epimerase
DXY22_01677	COG0189	ligase activity
DXY22_01678	COG0189	ligase activity
DXY22_01679	COG4399	Belongs to the UPF0754 family
DXY22_01680	COG3679	Belongs to the UPF0342 family
DXY22_01681	COG4335	DNA alkylation repair
DXY22_01682	COG0561	phosphatase activity
DXY22_01683	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DXY22_01684	COG0475	glutathione-regulated potassium exporter activity
DXY22_01685	COG0490	domain, Protein
DXY22_01687	COG1024	Enoyl-CoA hydratase
DXY22_01689	COG4152	abc transporter atp-binding protein
DXY22_01690	COG1668	transmembrane transport
DXY22_01691	COG0420	3'-5' exonuclease activity
DXY22_01692	COG4717	serine-type aminopeptidase activity
DXY22_01693	COG3481	metal-dependent phosphohydrolase, HD sub domain
DXY22_01695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DXY22_01698	COG1846	Transcriptional regulator
DXY22_01699	COG4980	gas vesicle protein
DXY22_01701	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
DXY22_01702	COG0537	adenosine 5'-monophosphoramidase activity
DXY22_01703	COG1131	(ABC) transporter
DXY22_01704	COG4473	ABC transporter
DXY22_01706	COG1473	amidohydrolase
DXY22_01707	COG3069	C4-dicarboxylate transmembrane transporter activity
DXY22_01709	COG2329	Antibiotic biosynthesis monooxygenase
DXY22_01710	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DXY22_01711	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DXY22_01714	COG1309	transcriptional regulator
DXY22_01715	COG1511	domain protein
DXY22_01716	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DXY22_01717	COG4377	Putative membrane peptidase family (DUF2324)
DXY22_01718	COG1363	Peptidase, m42
DXY22_01719	COG4405	Protein conserved in bacteria
DXY22_01720	COG1301	dicarboxylic acid transport
DXY22_01721	COG1234	tRNA 3'-trailer cleavage
DXY22_01722	COG0095	Lipoate-protein ligase
DXY22_01723	COG0702	epimerase
DXY22_01724	COG0318	PFAM AMP-dependent synthetase and ligase
DXY22_01726	COG0501	Belongs to the peptidase M48B family
DXY22_01728	COG0456	acetyltransferase
DXY22_01729	COG0604	alcohol dehydrogenase
DXY22_01730	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
DXY22_01731	COG0406	alpha-ribazole phosphatase activity
DXY22_01732	COG0183	Belongs to the thiolase family
DXY22_01733	COG0318	PFAM AMP-dependent synthetase and ligase
DXY22_01734	COG1268	BioY protein
DXY22_01735	COG0840	transmembrane signaling receptor activity
DXY22_01736	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DXY22_01736	COG0723	plastoquinol--plastocyanin reductase activity
DXY22_01737	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_01739	COG4903	ComK protein
DXY22_01740	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_01742	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DXY22_01745	COG0398	Pfam SNARE associated Golgi protein
DXY22_01746	COG0681	Belongs to the peptidase S26 family
DXY22_01747	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DXY22_01748	COG1846	Transcriptional regulator
DXY22_01749	COG0738	Major facilitator superfamily
DXY22_01750	COG0673	inositol 2-dehydrogenase activity
DXY22_01751	COG0561	phosphatase activity
DXY22_01752	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DXY22_01753	COG1609	Transcriptional regulator
DXY22_01754	COG3180	Ammonia monooxygenase
DXY22_01755	COG2814	Major facilitator Superfamily
DXY22_01755	COG0477	Major facilitator Superfamily
DXY22_01756	COG4533	DNA binding
DXY22_01758	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
DXY22_01759	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
DXY22_01760	COG1074	ATP-dependent DNA helicase activity
DXY22_01761	COG0420	3'-5' exonuclease activity
DXY22_01762	COG0419	ATPase involved in DNA repair
DXY22_01763	COG1403	HNH endonuclease
DXY22_01771	COG5337	Spore coat protein CotH
DXY22_01772	COG0179	Fumarylacetoacetate (FAA) hydrolase
DXY22_01774	COG1404	Belongs to the peptidase S8 family
DXY22_01776	COG0367	asparagine synthase
DXY22_01777	COG2318	DinB family
DXY22_01778	COG1562	ergosterol biosynthetic process
DXY22_01779	COG0534	Mate efflux family protein
DXY22_01780	COG1917	Cupin 2, conserved barrel domain protein
DXY22_01780	COG2207	Transcriptional regulator
DXY22_01781	COG1609	Transcriptional regulator
DXY22_01782	COG0673	inositol 2-dehydrogenase activity
DXY22_01783	COG2318	DinB family
DXY22_01784	COG1279	arginine transmembrane transporter activity
DXY22_01785	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DXY22_01786	COG1357	PFAM Pentapeptide repeats (8 copies)
DXY22_01787	COG2267	carboxylic ester hydrolase activity
DXY22_01788	COG0529	Catalyzes the synthesis of activated sulfate
DXY22_01789	COG2046	Belongs to the sulfate adenylyltransferase family
DXY22_01790	COG0175	sulfate reduction
DXY22_01791	COG2045	Belongs to the ComB family
DXY22_01792	COG1809	phosphosulfolactate synthase activity
DXY22_01793	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DXY22_01794	COG4948	Mandelate Racemase Muconate Lactonizing
DXY22_01795	COG2814	Major facilitator Superfamily
DXY22_01796	COG0454	-acetyltransferase
DXY22_01797	COG2153	protein acetylation
DXY22_01798	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DXY22_01798	COG0646	methionine synthase
DXY22_01799	COG1666	GTP binding
DXY22_01800	COG2996	Protein conserved in bacteria
DXY22_01804	COG1695	Transcriptional regulator
DXY22_01807	COG3227	Zinc metalloprotease (Elastase)
DXY22_01808	COG1307	EDD domain protein, DegV family
DXY22_01809	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DXY22_01813	COG0561	phosphatase activity
DXY22_01814	COG1073	alpha beta
DXY22_01815	COG2151	metal-sulfur cluster biosynthetic enzyme
DXY22_01817	COG0277	FAD linked oxidase domain protein
DXY22_01818	COG0277	FAD linked oxidase domain protein
DXY22_01819	COG2271	Major facilitator Superfamily
DXY22_01820	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DXY22_01821	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
DXY22_01823	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DXY22_01824	COG0505	Belongs to the CarA family
DXY22_01825	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DXY22_01826	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DXY22_01829	COG2267	carboxylic ester hydrolase activity
DXY22_01831	COG1744	ABC transporter substrate-binding protein PnrA-like
DXY22_01834	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DXY22_01835	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DXY22_01836	COG5504	Zn-dependent protease
DXY22_01837	COG0444	Belongs to the ABC transporter superfamily
DXY22_01838	COG4608	Belongs to the ABC transporter superfamily
DXY22_01840	COG0601	transmembrane transport
DXY22_01841	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DXY22_01843	COG0180	Tryptophanyl-tRNA synthetase
DXY22_01844	COG4166	transmembrane transport
DXY22_01845	COG0601	transmembrane transport
DXY22_01846	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DXY22_01847	COG0444	Belongs to the ABC transporter superfamily
DXY22_01848	COG4608	Belongs to the ABC transporter superfamily
DXY22_01849	COG2814	Major facilitator Superfamily
DXY22_01850	COG0456	acetyltransferase
DXY22_01851	COG1393	Belongs to the ArsC family
DXY22_01852	COG0861	Integral membrane protein TerC family
DXY22_01853	COG4862	establishment of competence for transformation
DXY22_01854	COG4469	Competence protein
DXY22_01855	COG1164	Oligoendopeptidase f
DXY22_01859	COG2346	COG2346, Truncated hemoglobins
DXY22_01860	COG0741	lytic transglycosylase activity
DXY22_01861	COG4116	CYTH
DXY22_01863	COG2357	RelA SpoT domain protein
DXY22_01864	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DXY22_01865	COG0564	pseudouridine synthase activity
DXY22_01866	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
DXY22_01867	COG0569	domain protein
DXY22_01867	COG0475	glutathione-regulated potassium exporter activity
DXY22_01868	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DXY22_01869	COG0352	thiamine-phosphate diphosphorylase activity
DXY22_01870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DXY22_01871	COG2104	thiamine diphosphate biosynthetic process
DXY22_01872	COG2022	thiamine diphosphate biosynthetic process
DXY22_01873	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DXY22_01874	COG0351	phosphomethylpyrimidine kinase
DXY22_01875	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DXY22_01886	COG0210	DNA helicase
DXY22_01888	COG2153	protein acetylation
DXY22_01889	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DXY22_01890	COG2382	esterase
DXY22_01894	COG0626	cystathionine gamma-synthase activity
DXY22_01895	COG0626	cystathionine gamma-synthase activity
DXY22_01896	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DXY22_01897	COG5505	Protein of unknown function (DUF819)
DXY22_01903	COG3677	Transposase
DXY22_01905	COG5484	DNA packaging
DXY22_01906	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
DXY22_01907	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_01909	COG3711	transcriptional antiterminator
DXY22_01909	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DXY22_01910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DXY22_01910	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DXY22_01910	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DXY22_01911	COG1482	cell wall glycoprotein biosynthetic process
DXY22_01913	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DXY22_01915	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DXY22_01918	COG0109	protoheme IX farnesyltransferase activity
DXY22_01920	COG0726	polysaccharide deacetylase
DXY22_01923	COG5504	Zn-dependent protease
DXY22_01924	COG2205	protein histidine kinase activity
DXY22_01926	COG3383	formate dehydrogenase (NAD+) activity
DXY22_01927	COG2427	Protein of unknown function (DUF1641)
DXY22_01929	COG1051	belongs to the nudix hydrolase family
DXY22_01931	COG2124	cytochrome p450
DXY22_01932	COG1819	glycosyl
DXY22_01934	COG1587	Uroporphyrinogen-III synthase
DXY22_01935	COG0390	transport system, permease component
DXY22_01936	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DXY22_01937	COG0697	spore germination
DXY22_01938	COG4297	protein containing double-stranded beta helix domain
DXY22_01940	COG1252	NADH dehydrogenase
DXY22_01941	COG1904	glucuronate isomerase
DXY22_01942	COG2211	Major facilitator Superfamily
DXY22_01943	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
DXY22_01944	COG1063	alcohol dehydrogenase
DXY22_01945	COG1312	Catalyzes the dehydration of D-mannonate
DXY22_01946	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_01947	COG2271	Major facilitator Superfamily
DXY22_01948	COG1609	Transcriptional regulator
DXY22_01949	COG0246	Mannitol dehydrogenase
DXY22_01950	COG2721	sulfolactate sulfo-lyase activity
DXY22_01951	COG0730	response to heat
DXY22_01952	COG2318	DinB family
DXY22_01953	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DXY22_01954	COG0457	Tetratricopeptide repeat
DXY22_01956	COG2350	Protein conserved in bacteria
DXY22_01957	COG5632	N-Acetylmuramoyl-L-alanine amidase
DXY22_01957	COG3409	Peptidoglycan-binding domain 1 protein
DXY22_01957	COG1388	LysM domain
DXY22_01959	COG4195	phage-related replication protein
DXY22_01960	COG3546	catalase activity
DXY22_01961	COG2856	Zn peptidase
DXY22_01962	COG1396	sequence-specific DNA binding
DXY22_01964	COG1522	sequence-specific DNA binding
DXY22_01965	COG1484	DNA-dependent DNA replication
DXY22_01969	COG1595	DNA-templated transcription, initiation
DXY22_01970	COG5484	DNA packaging
DXY22_01970	COG3728	DNA packaging
DXY22_01971	COG1783	phage Terminase large subunit
DXY22_01972	COG5518	Phage portal protein
DXY22_01973	COG0338	D12 class N6 adenine-specific DNA methyltransferase
DXY22_01974	COG4653	Phage capsid family
DXY22_01982	COG3953	SLT domain
DXY22_01982	COG5412	phage tail tape measure protein
DXY22_01982	COG3953	SLT domain
DXY22_01982	COG5412	phage tail tape measure protein
DXY22_01983	COG1652	LysM domain
DXY22_01984	COG4193	domain, Protein
DXY22_01986	COG3628	GPW Gp25 family protein
DXY22_01987	COG3299	homolog of phage Mu protein gp47
DXY22_01988	COG3778	Protein conserved in bacteria
DXY22_01996	COG3409	Peptidoglycan-binding domain 1 protein
DXY22_01996	COG5632	N-Acetylmuramoyl-L-alanine amidase
DXY22_01999	COG0306	phosphate transporter
DXY22_02000	COG1392	Phosphate transport regulator
DXY22_02001	COG0531	amino acid
DXY22_02002	COG0346	lactoylglutathione lyase activity
DXY22_02004	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DXY22_02005	COG0463	Glycosyl transferase, family 2
DXY22_02007	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DXY22_02008	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DXY22_02009	COG2362	D-Aminopeptidase
DXY22_02010	COG0601	transmembrane transport
DXY22_02011	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DXY22_02012	COG0444	Belongs to the ABC transporter superfamily
DXY22_02013	COG4166	transmembrane transport
DXY22_02015	COG1619	proteins homologs of microcin C7 resistance protein MccF
DXY22_02016	COG4948	Mandelate Racemase Muconate Lactonizing
DXY22_02017	COG0791	NLP P60 protein
DXY22_02018	COG4608	Belongs to the ABC transporter superfamily
DXY22_02019	COG2706	6-phosphogluconolactonase activity
DXY22_02020	COG1834	amidinotransferase
DXY22_02021	COG1607	acyl-coa hydrolase
DXY22_02022	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DXY22_02022	COG1017	nitric oxide dioxygenase activity
DXY22_02024	COG2323	membrane
DXY22_02025	COG2318	DinB family
DXY22_02026	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DXY22_02027	COG2076	Multidrug Resistance protein
DXY22_02028	COG2076	Multidrug Resistance protein
DXY22_02029	COG0788	formyltetrahydrofolate deformylase activity
DXY22_02030	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DXY22_02031	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DXY22_02032	COG1764	response to oxidative stress
DXY22_02033	COG1846	Transcriptional regulator
DXY22_02034	COG1764	response to oxidative stress
DXY22_02035	COG0590	tRNA wobble adenosine to inosine editing
DXY22_02036	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DXY22_02037	COG1404	Belongs to the peptidase S8 family
DXY22_02038	COG1366	Belongs to the anti-sigma-factor antagonist family
DXY22_02039	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
DXY22_02040	COG1122	ATPase activity
DXY22_02041	COG4721	ABC-type cobalt transport system, permease component
DXY22_02043	COG0745	RESPONSE REGULATOR receiver
DXY22_02044	COG3850	Histidine kinase
DXY22_02044	COG5002	protein histidine kinase activity
DXY22_02045	COG3212	peptidase
DXY22_02046	COG3212	peptidase
DXY22_02049	COG2239	Acts as a magnesium transporter
DXY22_02050	COG0789	Transcriptional regulator
DXY22_02053	COG1846	Transcriptional regulator
DXY22_02054	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DXY22_02055	COG0726	polysaccharide deacetylase
DXY22_02056	COG1408	metallophosphoesterase
DXY22_02058	COG0463	Glycosyl transferase, family 2
DXY22_02059	COG1793	dna ligase
DXY22_02059	COG3285	dna ligase
DXY22_02060	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
DXY22_02061	COG5001	Diguanylate cyclase
DXY22_02061	COG3300	MHYT domain
DXY22_02062	COG0586	Pfam SNARE associated Golgi protein
DXY22_02063	COG0861	Integral membrane protein TerC family
DXY22_02064	COG1191	sigma factor activity
DXY22_02068	COG0501	Belongs to the peptidase M48B family
DXY22_02069	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DXY22_02072	COG3594	Acyltransferase
DXY22_02073	COG5002	protein histidine kinase activity
DXY22_02074	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DXY22_02076	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
DXY22_02077	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
DXY22_02078	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DXY22_02079	COG0436	Aminotransferase
DXY22_02080	COG1850	ribulose-bisphosphate carboxylase activity
DXY22_02081	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
DXY22_02082	COG0235	Class ii aldolase
DXY22_02083	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
DXY22_02084	COG3339	Conserved Protein
DXY22_02087	COG3852	Histidine kinase
DXY22_02088	COG1846	Transcriptional regulator
DXY22_02089	COG1360	Flagellar Motor Protein
DXY22_02090	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DXY22_02091	COG0542	response to heat
DXY22_02092	COG3949	Membrane
DXY22_02093	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DXY22_02094	COG0720	synthase
DXY22_02095	COG0602	queuosine metabolic process
DXY22_02096	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DXY22_02097	COG1733	regulation of RNA biosynthetic process
DXY22_02098	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_02099	COG1388	LysM domain
DXY22_02099	COG4641	Protein conserved in bacteria
DXY22_02100	COG1388	LysM domain
DXY22_02101	COG3858	chitin binding
DXY22_02103	COG4873	Protein conserved in bacteria
DXY22_02105	COG3773	Cell wall hydrolase
DXY22_02106	COG2244	polysaccharide biosynthetic process
DXY22_02107	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY22_02108	COG2217	Heavy metal translocating P-type atpase
DXY22_02110	COG0006	proline dipeptidase activity
DXY22_02111	COG1609	Transcriptional regulator
DXY22_02113	COG3711	transcriptional antiterminator
DXY22_02114	COG1263	PTS System
DXY22_02114	COG2190	(PTS) system
DXY22_02114	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY22_02115	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DXY22_02116	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DXY22_02118	COG1533	DNA photolyase activity
DXY22_02119	COG0456	acetyltransferase
DXY22_02120	COG0840	transmembrane signaling receptor activity
DXY22_02121	COG2084	Dehydrogenase
DXY22_02122	COG2340	Cysteine-rich secretory protein family
DXY22_02123	COG0768	penicillin binding
DXY22_02124	COG4191	Histidine kinase
DXY22_02125	COG0436	Aminotransferase
DXY22_02127	COG0835	chemotaxis
DXY22_02127	COG0784	Response regulator, receiver
DXY22_02129	COG2814	Major facilitator Superfamily
DXY22_02130	COG1376	ErfK ybiS ycfS ynhG family protein
DXY22_02131	COG1408	metallophosphoesterase
DXY22_02132	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_02133	COG3409	Peptidoglycan-binding domain 1 protein
DXY22_02135	COG2200	EAL domain
DXY22_02136	COG4703	Protein of unknown function (DUF1797)
DXY22_02137	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
DXY22_02139	COG0517	IMP dehydrogenase activity
DXY22_02140	COG0583	DNA-binding transcription factor activity
DXY22_02141	COG0716	FMN binding
DXY22_02143	COG0716	FMN binding
DXY22_02144	COG2171	N-acyltransferase activity
DXY22_02145	COG1473	amidohydrolase
DXY22_02147	COG0668	transmembrane transport
DXY22_02148	COG0450	alkyl hydroperoxide reductase
DXY22_02149	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY22_02152	COG0746	molybdenum cofactor guanylyltransferase activity
DXY22_02153	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DXY22_02154	COG0303	'Molybdopterin
DXY22_02155	COG1763	Mo-molybdopterin cofactor biosynthetic process
DXY22_02156	COG0314	molybdopterin synthase activity
DXY22_02157	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DXY22_02158	COG1132	(ABC) transporter
DXY22_02159	COG1132	(ABC) transporter
DXY22_02161	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DXY22_02162	COG1136	(ABC) transporter
DXY22_02163	COG0577	efflux transmembrane transporter activity
DXY22_02164	COG1349	DNA-binding transcription factor activity
DXY22_02165	COG1105	Belongs to the carbohydrate kinase PfkB family
DXY22_02166	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DXY22_02166	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
DXY22_02166	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DXY22_02167	COG0681	Belongs to the peptidase S26 family
DXY22_02169	COG0488	(ABC) transporter
DXY22_02170	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DXY22_02171	COG2309	aminopeptidase activity
DXY22_02173	COG1077	Cell shape determining protein MreB Mrl
DXY22_02174	COG2002	toxin-antitoxin pair type II binding
DXY22_02175	COG3852	Histidine kinase
DXY22_02176	COG2105	PFAM AIG2 family protein
DXY22_02176	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
DXY22_02177	COG0569	domain protein
DXY22_02178	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
DXY22_02179	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DXY22_02181	COG0561	phosphatase activity
DXY22_02182	COG0242	peptide deformylase activity
DXY22_02184	COG0497	DNA recombination
DXY22_02185	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DXY22_02186	COG0022	dehydrogenase e1 component
DXY22_02187	COG0508	dehydrogenase complex catalyzes the overall conversion of
DXY22_02188	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DXY22_02189	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY22_02190	COG1982	Orn Lys Arg decarboxylase major
DXY22_02191	COG4476	Belongs to the UPF0223 family
DXY22_02192	COG4493	Belongs to the UPF0637 family
DXY22_02194	COG0483	inositol monophosphate 1-phosphatase activity
DXY22_02196	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
DXY22_02200	COG1595	DNA-templated transcription, initiation
DXY22_02206	COG4896	Protein conserved in bacteria
DXY22_02208	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DXY22_02209	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DXY22_02210	COG2066	Belongs to the glutaminase family
DXY22_02211	COG4838	Belongs to the UPF0358 family
DXY22_02212	COG0772	Belongs to the SEDS family
DXY22_02213	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DXY22_02214	COG1612	heme a metabolic process
DXY22_02215	COG0109	protoheme IX farnesyltransferase activity
DXY22_02216	COG2010	Cytochrome c
DXY22_02216	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DXY22_02217	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DXY22_02218	COG1845	cytochrome c oxidase, subunit III
DXY22_02219	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DXY22_02220	COG3336	cytochrome c oxidase
DXY22_02222	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
DXY22_02223	COG2340	Cysteine-rich secretory protein family
DXY22_02226	COG3679	Belongs to the UPF0342 family
DXY22_02227	COG4471	UPF0298 protein
DXY22_02228	COG0742	ribosomal rna small subunit methyltransferase
DXY22_02229	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DXY22_02230	COG3314	Sporulation integral membrane protein YlbJ
DXY22_02231	COG1752	Esterase of the alpha-beta hydrolase superfamily
DXY22_02232	COG3480	Lon protease (S16) C-terminal proteolytic domain
DXY22_02233	COG1323	Belongs to the UPF0348 family
DXY22_02235	COG1399	metal-binding, possibly nucleic acid-binding protein
DXY22_02238	COG0454	-acetyltransferase
DXY22_02239	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DXY22_02240	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
DXY22_02241	COG2001	Belongs to the MraZ family
DXY22_02242	COG0275	rRNA processing
DXY22_02243	COG4839	cell division protein FtsL
DXY22_02245	COG0768	penicillin binding
DXY22_02246	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DXY22_02247	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DXY22_02248	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DXY22_02249	COG0772	Belongs to the SEDS family
DXY22_02250	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DXY22_02251	COG0812	UDP-N-acetylmuramate dehydrogenase activity
DXY22_02252	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DXY22_02253	COG3879	Bacterial protein of unknown function (DUF881)
DXY22_02254	COG3879	Bacterial protein of unknown function (DUF881)
DXY22_02255	COG3856	small basic protein
DXY22_02256	COG0849	cell division
DXY22_02257	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DXY22_02258	COG4412	M6 family metalloprotease domain protein
DXY22_02258	COG1404	Belongs to the peptidase S8 family
DXY22_02260	COG1191	sigma factor activity
DXY22_02261	COG1191	sigma factor activity
DXY22_02262	COG1119	ATPase activity
DXY22_02263	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DXY22_02264	COG1873	PFAM PRC-barrel domain
DXY22_02266	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DXY22_02267	COG1799	cell septum assembly
DXY22_02268	COG0762	integral membrane protein
DXY22_02269	COG2302	S4 RNA-binding domain
DXY22_02270	COG3599	regulation of cell shape
DXY22_02271	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DXY22_02272	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DXY22_02273	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DXY22_02274	COG0564	pseudouridine synthase activity
DXY22_02275	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DXY22_02276	COG2233	PERMEase
DXY22_02277	COG0540	Belongs to the ATCase OTCase family
DXY22_02278	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DXY22_02279	COG0505	Belongs to the CarA family
DXY22_02280	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DXY22_02281	COG0543	2 iron, 2 sulfur cluster binding
DXY22_02282	COG0167	dihydroorotate dehydrogenase activity
DXY22_02283	COG0284	orotidine-5'-phosphate decarboxylase activity
DXY22_02284	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DXY22_02286	COG0175	sulfate reduction
DXY22_02287	COG0306	phosphate transporter
DXY22_02288	COG2046	Belongs to the sulfate adenylyltransferase family
DXY22_02289	COG0529	Catalyzes the synthesis of activated sulfate
DXY22_02290	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DXY22_02291	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
DXY22_02292	COG1648	precorrin-2 dehydrogenase activity
DXY22_02293	COG1293	RNA-binding protein homologous to eukaryotic snRNP
DXY22_02294	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
DXY22_02295	COG1561	YicC-like family, N-terminal region
DXY22_02297	COG0194	GDP metabolic process
DXY22_02298	COG1758	RNA polymerase activity
DXY22_02299	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DXY22_02300	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DXY22_02301	COG0242	peptide deformylase activity
DXY22_02302	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DXY22_02303	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DXY22_02303	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DXY22_02304	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DXY22_02305	COG0631	protein serine/threonine phosphatase activity
DXY22_02306	COG2815	serine threonine protein kinase
DXY22_02306	COG0515	serine threonine protein kinase
DXY22_02307	COG1162	GTPase activity
DXY22_02308	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DXY22_02309	COG1564	THIamine pyrophosphokinase
DXY22_02310	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DXY22_02311	COG1302	Protein conserved in bacteria
DXY22_02312	COG1461	Dihydroxyacetone kinase
DXY22_02313	COG1760	l-serine dehydratase
DXY22_02314	COG1760	l-serine dehydratase
DXY22_02315	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DXY22_02316	COG2050	protein possibly involved in aromatic compounds catabolism
DXY22_02316	COG1349	DNA-binding transcription factor activity
DXY22_02317	COG0416	fatty acid biosynthetic process
DXY22_02318	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DXY22_02319	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_02321	COG0571	ribonuclease III activity
DXY22_02322	COG1196	nuclear chromosome segregation
DXY22_02323	COG0552	protein localization to endoplasmic reticulum
DXY22_02325	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
DXY22_02326	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DXY22_02327	COG0228	four-way junction DNA binding
DXY22_02328	COG1837	Belongs to the UPF0109 family
DXY22_02330	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DXY22_02331	COG0336	Belongs to the RNA methyltransferase TrmD family
DXY22_02332	COG0335	large ribosomal subunit rRNA binding
DXY22_02333	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DXY22_02334	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DXY22_02336	COG2257	FlhB HrpN YscU SpaS Family
DXY22_02337	COG0045	succinate-CoA ligase (ADP-forming) activity
DXY22_02338	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DXY22_02339	COG0758	DNA mediated transformation
DXY22_02340	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DXY22_02341	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
DXY22_02342	COG4974	Belongs to the 'phage' integrase family
DXY22_02343	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DXY22_02344	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DXY22_02345	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DXY22_02346	COG1815	bacterial-type flagellum-dependent cell motility
DXY22_02347	COG1558	bacterial-type flagellum-dependent cell motility
DXY22_02348	COG1677	Flagellar hook-basal body complex protein FliE
DXY22_02349	COG1766	The M ring may be actively involved in energy transduction
DXY22_02350	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DXY22_02351	COG1317	bacterial-type flagellum organization
DXY22_02352	COG1157	protein secretion by the type III secretion system
DXY22_02353	COG2882	bacterial-type flagellum organization
DXY22_02354	COG3334	PFAM MgtE intracellular
DXY22_02355	COG3144	bacterial-type flagellum assembly
DXY22_02356	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DXY22_02357	COG4786	Flagellar basal body rod
DXY22_02358	COG1580	Controls the rotational direction of flagella during chemotaxis
DXY22_02359	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DXY22_02360	COG1776	CheC inhibitor of MCP methylation
DXY22_02360	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DXY22_02361	COG2201	protein-glutamate methylesterase activity
DXY22_02362	COG3190	flagellar
DXY22_02363	COG1338	Plays a role in the flagellum-specific transport system
DXY22_02364	COG1987	bacterial-type flagellum assembly
DXY22_02365	COG1684	flagellar biosynthetic protein fliR
DXY22_02366	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DXY22_02367	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DXY22_02368	COG1419	protein localization to endoplasmic reticulum
DXY22_02369	COG0455	bacterial-type flagellum organization
DXY22_02370	COG2201	protein-glutamate methylesterase activity
DXY22_02371	COG2198	Histidine kinase
DXY22_02371	COG0643	Histidine kinase
DXY22_02372	COG0835	chemotaxis
DXY22_02373	COG1776	CheC inhibitor of MCP methylation
DXY22_02374	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
DXY22_02375	COG1191	sigma factor activity
DXY22_02377	COG0052	Belongs to the universal ribosomal protein uS2 family
DXY22_02378	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DXY22_02379	COG0528	UMP kinase activity
DXY22_02380	COG0233	cytoplasmic translational termination
DXY22_02381	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DXY22_02382	COG4589	Belongs to the CDS family
DXY22_02383	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
DXY22_02384	COG0750	zinc metalloprotease
DXY22_02385	COG0442	prolyl-tRNA aminoacylation
DXY22_02386	COG2176	DNA-directed DNA polymerase activity
DXY22_02387	COG0779	Required for maturation of 30S ribosomal subunits
DXY22_02388	COG0195	Participates in both transcription termination and antitermination
DXY22_02389	COG2740	Nucleic-acid-binding protein implicated in transcription termination
DXY22_02390	COG1358	cellular component organization or biogenesis
DXY22_02391	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DXY22_02392	COG1550	Protein conserved in bacteria
DXY22_02393	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DXY22_02394	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
DXY22_02395	COG0196	riboflavin kinase activity
DXY22_02396	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DXY22_02397	COG1185	polyribonucleotide nucleotidyltransferase activity
DXY22_02398	COG0726	polysaccharide deacetylase
DXY22_02399	COG0612	Peptidase, M16
DXY22_02400	COG1873	PFAM PRC-barrel domain
DXY22_02401	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DXY22_02402	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DXY22_02403	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DXY22_02404	COG0527	aspartate kinase activity
DXY22_02405	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DXY22_02406	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DXY22_02407	COG0740	serine-type endopeptidase activity
DXY22_02409	COG4980	gas vesicle protein
DXY22_02409	COG1674	ftsk spoiiie
DXY22_02410	COG2188	Transcriptional regulator
DXY22_02411	COG2814	Major facilitator Superfamily
DXY22_02412	COG0612	Peptidase, M16
DXY22_02413	COG0612	Peptidase, M16
DXY22_02414	COG0300	oxidoreductase activity
DXY22_02417	COG1426	Protein conserved in bacteria
DXY22_02418	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DXY22_02419	COG1058	Belongs to the CinA family
DXY22_02419	COG1546	Belongs to the CinA family
DXY22_02420	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DXY22_02421	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DXY22_02422	COG1418	mRNA catabolic process
DXY22_02423	COG1692	metallophosphoesterase
DXY22_02424	COG2359	stage V sporulation protein S
DXY22_02425	COG1063	alcohol dehydrogenase
DXY22_02426	COG0156	8-amino-7-oxononanoate synthase activity
DXY22_02427	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DXY22_02428	COG4550	Control of competence regulator ComK, YlbF/YmcA
DXY22_02430	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DXY22_02431	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DXY22_02434	COG3226	Transcriptional regulator
DXY22_02435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DXY22_02436	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DXY22_02438	COG3321	synthase
DXY22_02439	COG2070	2-Nitropropane dioxygenase
DXY22_02439	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DXY22_02440	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DXY22_02441	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DXY22_02442	COG3425	synthase
DXY22_02443	COG1024	Enoyl-CoA hydratase
DXY22_02444	COG1024	Enoyl-CoA hydratase
DXY22_02445	COG0300	oxidoreductase activity
DXY22_02445	COG0318	PFAM AMP-dependent synthetase and ligase
DXY22_02445	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_02445	COG3321	synthase
DXY22_02445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_02446	COG3321	synthase
DXY22_02446	COG4221	oxidoreductase activity
DXY22_02446	COG0300	oxidoreductase activity
DXY22_02446	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DXY22_02447	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DXY22_02447	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DXY22_02447	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_02447	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_02447	COG3321	synthase
DXY22_02448	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_02448	COG3321	synthase
DXY22_02448	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_02448	COG4221	oxidoreductase activity
DXY22_02449	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DXY22_02449	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DXY22_02449	COG3321	synthase
DXY22_02449	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DXY22_02450	COG2124	cytochrome p450
DXY22_02452	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DXY22_02453	COG1404	Belongs to the peptidase S8 family
DXY22_02455	COG4195	phage-related replication protein
DXY22_02456	COG1764	response to oxidative stress
DXY22_02457	COG2076	Multidrug Resistance protein
DXY22_02458	COG2076	Multidrug Resistance protein
DXY22_02461	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
DXY22_02462	COG1923	regulation of RNA biosynthetic process
DXY22_02465	COG1780	Probably involved in ribonucleotide reductase function
DXY22_02466	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DXY22_02467	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DXY22_02468	COG4112	unkown
DXY22_02469	COG0860	N-Acetylmuramoyl-L-alanine amidase
DXY22_02470	COG0464	growth
DXY22_02471	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DXY22_02472	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
DXY22_02473	COG0789	Transcriptional regulator
DXY22_02474	COG0174	glutamine synthetase
DXY22_02478	COG4282	regulation of fungal-type cell wall biogenesis
DXY22_02480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DXY22_02483	COG3655	Transcriptional regulator
DXY22_02487	COG0135	phosphoribosylanthranilate isomerase activity
DXY22_02488	COG2211	Major facilitator Superfamily
DXY22_02489	COG3507	Belongs to the glycosyl hydrolase 43 family
DXY22_02490	COG1940	carbohydrate kinase activity
DXY22_02491	COG2115	Belongs to the xylose isomerase family
DXY22_02492	COG1070	Carbohydrate kinase
DXY22_02493	COG1525	nuclease
DXY22_02494	COG2814	Major facilitator Superfamily
DXY22_02495	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DXY22_02497	COG0756	dUTP diphosphatase activity
DXY22_02506	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DXY22_02508	COG3832	glyoxalase III activity
DXY22_02511	COG0697	spore germination
DXY22_02512	COG0531	amino acid
DXY22_02518	COG4195	phage-related replication protein
DXY22_02520	COG0346	lactoylglutathione lyase activity
DXY22_02521	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DXY22_02522	COG1388	LysM domain
DXY22_02523	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DXY22_02524	COG4224	UPF0291 protein
DXY22_02525	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DXY22_02527	COG3763	UPF0154 protein
DXY22_02529	COG0785	Cytochrome C biogenesis protein
DXY22_02530	COG2201	protein-glutamate methylesterase activity
DXY22_02531	COG4846	Membrane protein involved in cytochrome C biogenesis
DXY22_02533	COG0071	Belongs to the small heat shock protein (HSP20) family
DXY22_02536	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DXY22_02537	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY22_02541	COG0824	Thioesterase
DXY22_02543	COG4841	protein insertion into membrane
DXY22_02544	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DXY22_02545	COG1832	CoA-binding protein
DXY22_02546	COG0187	DNA topoisomerase II activity
DXY22_02547	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DXY22_02550	COG1115	amino acid carrier protein
DXY22_02551	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
DXY22_02553	COG5520	Belongs to the glycosyl hydrolase 30 family
DXY22_02554	COG3507	Belongs to the glycosyl hydrolase 43 family
DXY22_02555	COG2246	polysaccharide biosynthetic process
DXY22_02556	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DXY22_02557	COG0586	Pfam SNARE associated Golgi protein
DXY22_02558	COG2404	hydrolase activity, acting on ester bonds
DXY22_02559	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DXY22_02560	COG1024	Enoyl-CoA hydratase
DXY22_02561	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DXY22_02562	COG0511	ligase activity, forming carbon-carbon bonds
DXY22_02563	COG0439	Biotin carboxylase
DXY22_02564	COG0318	PFAM AMP-dependent synthetase and ligase
DXY22_02565	COG1960	acyl-CoA dehydrogenase activity
DXY22_02566	COG1649	PFAM Uncharacterised BCR, COG1649
DXY22_02568	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_02568	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
DXY22_02569	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_02570	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_02571	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_02572	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_02573	COG2027	D-alanyl-D-alanine carboxypeptidase
DXY22_02574	COG2017	converts alpha-aldose to the beta-anomer
DXY22_02575	COG0534	Mate efflux family protein
DXY22_02578	COG0582	viral genome integration into host DNA
DXY22_02579	COG0166	Belongs to the GPI family
DXY22_02580	COG0405	Gamma-glutamyltransferase
DXY22_02581	COG0583	DNA-binding transcription factor activity
DXY22_02582	COG0604	alcohol dehydrogenase
DXY22_02583	COG0493	'glutamate synthase
DXY22_02584	COG0069	glutamate synthase activity
DXY22_02584	COG0067	glutamate synthase
DXY22_02584	COG0070	glutamate synthase
DXY22_02585	COG0583	DNA-binding transcription factor activity
DXY22_02586	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
DXY22_02587	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DXY22_02589	COG0300	oxidoreductase activity
DXY22_02590	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DXY22_02592	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DXY22_02595	COG1131	(ABC) transporter
DXY22_02597	COG2814	Major facilitator Superfamily
DXY22_02598	COG1070	Carbohydrate kinase
DXY22_02599	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DXY22_02600	COG0243	molybdopterin cofactor binding
DXY22_02605	COG5278	phosphoserine phosphatase activity
DXY22_02605	COG0840	transmembrane signaling receptor activity
DXY22_02606	COG2368	4-hydroxyphenylacetate
DXY22_02607	COG4305	rare lipoprotein A
DXY22_02608	COG3619	membrane
DXY22_02609	COG3866	Pectate lyase
DXY22_02610	COG2135	peptidase activity
DXY22_02613	COG2140	Oxalate decarboxylase
DXY22_02615	COG0456	acetyltransferase
DXY22_02619	COG2720	vancomycin resistance protein
DXY22_02621	COG3655	Transcriptional regulator
DXY22_02622	COG3739	integral membrane protein
DXY22_02623	COG0583	DNA-binding transcription factor activity
DXY22_02624	COG0697	spore germination
DXY22_02626	COG0693	protein deglycase activity
DXY22_02627	COG2367	Beta-lactamase
DXY22_02630	COG3848	Pyruvate phosphate dikinase
DXY22_02630	COG0574	Belongs to the PEP-utilizing enzyme family
DXY22_02631	COG0726	polysaccharide deacetylase
DXY22_02633	COG2314	TM2 domain
DXY22_02634	COG1396	sequence-specific DNA binding
DXY22_02637	COG2135	peptidase activity
DXY22_02638	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DXY22_02641	COG2723	6-phospho-beta-galactosidase activity
DXY22_02644	COG0395	ABC-type sugar transport system, permease component
DXY22_02645	COG1175	transmembrane transport
DXY22_02647	COG1940	carbohydrate kinase activity
DXY22_02649	COG5444	nuclease activity
DXY22_02650	COG4282	regulation of fungal-type cell wall biogenesis
DXY22_02651	COG1231	oxidoreductase activity
DXY22_02652	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DXY22_02653	COG2207	Transcriptional regulator
DXY22_02653	COG0662	Cupin 2, conserved barrel domain protein
DXY22_02654	COG0456	acetyltransferase
DXY22_02655	COG1309	transcriptional regulator
DXY22_02656	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DXY22_02657	COG3708	Transcriptional regulator
DXY22_02658	COG2378	regulation of single-species biofilm formation
DXY22_02660	COG0640	Transcriptional regulator
DXY22_02661	COG0741	lytic transglycosylase activity
DXY22_02662	COG2322	membrane
DXY22_02665	COG1619	proteins homologs of microcin C7 resistance protein MccF
DXY22_02666	COG3239	Fatty acid desaturase
DXY22_02667	COG4585	Histidine kinase
DXY22_02668	COG2197	response regulator
DXY22_02669	COG3584	3D domain protein
DXY22_02669	COG1388	LysM domain
DXY22_02670	COG0514	ATP-dependent DNA helicase (RecQ)
DXY22_02672	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DXY22_02673	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DXY22_02676	COG0071	Belongs to the small heat shock protein (HSP20) family
DXY22_02681	COG1012	belongs to the aldehyde dehydrogenase family
DXY22_02682	COG1657	PFAM Prenyltransferase squalene oxidase
DXY22_02683	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DXY22_02684	COG0733	neurotransmitter:sodium symporter activity
DXY22_02685	COG0385	Bile acid
DXY22_02686	COG0508	dehydrogenase complex catalyzes the overall conversion of
DXY22_02687	COG0567	Dehydrogenase, E1 component
DXY22_02688	COG4548	von Willebrand factor, type A
DXY22_02689	COG0714	Associated with various cellular activities
DXY22_02690	COG2032	superoxide dismutase activity
DXY22_02691	COG0791	NLP P60 protein
DXY22_02691	COG1388	LysM domain
DXY22_02692	COG1819	glycosyl
DXY22_02693	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
DXY22_02695	COG0534	Mate efflux family protein
DXY22_02696	COG1366	Belongs to the anti-sigma-factor antagonist family
DXY22_02697	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DXY22_02698	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DXY22_02700	COG2962	Rard protein
DXY22_02703	COG2610	gluconate transmembrane transporter activity
DXY22_02704	COG1942	4-Oxalocrotonate Tautomerase
DXY22_02705	COG1733	regulation of RNA biosynthetic process
DXY22_02706	COG0778	Nitroreductase
DXY22_02707	COG0400	carboxylic ester hydrolase activity
DXY22_02708	COG0346	lactoylglutathione lyase activity
DXY22_02710	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DXY22_02711	COG0793	Belongs to the peptidase S41A family
DXY22_02711	COG3409	Peptidoglycan-binding domain 1 protein
DXY22_02712	COG2226	methyltransferase
DXY22_02714	COG1876	peptidase activity
DXY22_02715	COG0813	purine-nucleoside phosphorylase activity
DXY22_02718	COG0671	phosphoesterase, PA-phosphatase related
DXY22_02722	COG4479	Belongs to the UPF0346 family
DXY22_02724	COG1509	lysine 2,3-aminomutase activity
DXY22_02725	COG0456	acetyltransferase
DXY22_02726	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DXY22_02727	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
DXY22_02728	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
DXY22_02729	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DXY22_02731	COG0456	acetyltransferase
DXY22_02732	COG0463	Glycosyl transferase, family 2
DXY22_02735	COG4641	Protein conserved in bacteria
DXY22_02736	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
DXY22_02737	COG1086	Polysaccharide biosynthesis protein
DXY22_02738	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DXY22_02739	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DXY22_02740	COG1846	Transcriptional regulator
DXY22_02741	COG0534	Mate efflux family protein
DXY22_02743	COG4698	Protein conserved in bacteria
DXY22_02744	COG2755	lipolytic protein G-D-S-L family
DXY22_02745	COG1999	signal sequence binding
DXY22_02747	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DXY22_02748	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DXY22_02749	COG1272	protein, Hemolysin III
DXY22_02750	COG0204	Acyl-transferase
DXY22_02751	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DXY22_02752	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DXY22_02753	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DXY22_02755	COG2521	methyltransferase
DXY22_02755	COG2136	Putative SAM-dependent methyltransferase
DXY22_02757	COG0129	dihydroxy-acid dehydratase activity
DXY22_02758	COG1413	lyase activity
DXY22_02759	COG1418	mRNA catabolic process
DXY22_02760	COG0386	Belongs to the glutathione peroxidase family
DXY22_02761	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DXY22_02762	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DXY22_02763	COG1278	Cold shock
DXY22_02767	COG0328	RNA-DNA hybrid ribonuclease activity
DXY22_02768	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DXY22_02769	COG0328	RNA-DNA hybrid ribonuclease activity
DXY22_02771	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DXY22_02774	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DXY22_02775	COG1755	Isoprenylcysteine carboxyl methyltransferase
DXY22_02776	COG3424	synthase
DXY22_02777	COG2233	PERMEase
DXY22_02778	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DXY22_02779	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
DXY22_02781	COG0800	Aldolase
DXY22_02782	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DXY22_02783	COG1609	Transcriptional regulator
DXY22_02784	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
DXY22_02785	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_02786	COG1199	ATP-dependent helicase activity
DXY22_02789	COG0116	Belongs to the methyltransferase superfamily
DXY22_02791	COG4474	Belongs to the UPF0398 family
DXY22_02792	COG3359	exonuclease
DXY22_02793	COG1205	dead DEAH box helicase
DXY22_02793	COG1111	helicase
DXY22_02794	COG2190	(PTS) system
DXY22_02795	COG0071	Belongs to the small heat shock protein (HSP20) family
DXY22_02801	COG3331	DNA recombination
DXY22_02802	COG4499	WXG100 protein secretion system (Wss), protein YukC
DXY22_02802	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DXY22_02804	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DXY22_02805	COG3935	DnaD domain protein
DXY22_02806	COG0017	Asparaginyl-tRNA synthetase
DXY22_02807	COG0436	Aminotransferase
DXY22_02808	COG5353	protein conserved in bacteria
DXY22_02810	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DXY22_02810	COG1199	ATP-dependent helicase activity
DXY22_02811	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DXY22_02812	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DXY22_02813	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
DXY22_02814	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DXY22_02814	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DXY22_02815	COG0617	tRNA 3'-terminal CCA addition
DXY22_02816	COG0438	transferase activity, transferring glycosyl groups
DXY22_02817	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
DXY22_02818	COG1803	Methylglyoxal synthase
DXY22_02819	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DXY22_02820	COG1694	Mazg nucleotide pyrophosphohydrolase
DXY22_02821	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DXY22_02823	COG4347	Protein of unknown function (DUF1405)
DXY22_02824	COG2010	Cytochrome c
DXY22_02824	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DXY22_02825	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DXY22_02826	COG0723	plastoquinol--plastocyanin reductase activity
DXY22_02828	COG5582	Belongs to the UPF0302 family
DXY22_02829	COG0457	Tetratricopeptide repeat
DXY22_02830	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DXY22_02831	COG0287	Prephenate dehydrogenase
DXY22_02832	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DXY22_02833	COG0159	tryptophan synthase activity
DXY22_02834	COG0133	tryptophan synthase activity
DXY22_02835	COG0135	phosphoribosylanthranilate isomerase activity
DXY22_02837	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DXY22_02838	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DXY22_02839	COG4401	Chorismate mutase type I
DXY22_02840	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DXY22_02841	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DXY22_02842	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DXY22_02843	COG0105	UTP biosynthetic process
DXY22_02844	COG0142	geranyltranstransferase activity
DXY22_02845	COG2226	methyltransferase
DXY22_02846	COG0142	geranyltranstransferase activity
DXY22_02848	COG0302	gtp cyclohydrolase
DXY22_02849	COG0776	regulation of translation
DXY22_02850	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
DXY22_02853	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DXY22_02854	COG1160	GTP binding
DXY22_02859	COG1304	FMN binding
DXY22_02860	COG0539	negative regulation of cytoplasmic translation
DXY22_02861	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DXY22_02863	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
DXY22_02864	COG2959	enzyme of heme biosynthesis
DXY22_02865	COG3773	Cell wall hydrolase
DXY22_02865	COG3409	Peptidoglycan-binding domain 1 protein
DXY22_02866	COG2339	peptidase activity
DXY22_02867	COG0492	ferredoxin-NADP+ reductase activity
DXY22_02868	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DXY22_02869	COG4862	establishment of competence for transformation
DXY22_02870	COG1408	metallophosphoesterase
DXY22_02872	COG1388	LysM domain
DXY22_02873	COG1266	CAAX protease self-immunity
DXY22_02874	COG0514	ATP-dependent DNA helicase (RecQ)
DXY22_02875	COG4955	Helix-turn-helix domain
DXY22_02876	COG1141	Ferredoxin
DXY22_02877	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
DXY22_02878	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DXY22_02879	COG0710	3-dehydroquinate dehydratase activity
DXY22_02881	COG1595	DNA-templated transcription, initiation
DXY22_02882	COG5002	protein histidine kinase activity
DXY22_02883	COG0745	RESPONSE REGULATOR receiver
DXY22_02884	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DXY22_02885	COG1333	cytochrome c biogenesis protein
DXY22_02886	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY22_02887	COG1187	pseudouridine synthase activity
DXY22_02888	COG0700	Nucleoside recognition
DXY22_02889	COG2715	membrane protein required for spore maturation
DXY22_02890	COG1686	Belongs to the peptidase S11 family
DXY22_02892	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DXY22_02893	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DXY22_02894	COG1547	Domain of unknown function (DUF309)
DXY22_02895	COG0456	acetyltransferase
DXY22_02896	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DXY22_02897	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DXY22_02897	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DXY22_02898	COG0307	riboflavin synthase, alpha
DXY22_02899	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DXY22_02899	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DXY22_02901	COG0681	Belongs to the peptidase S26 family
DXY22_02902	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
DXY22_02905	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DXY22_02906	COG4086	secreted protein
DXY22_02907	COG0019	diaminopimelate decarboxylase activity
DXY22_02908	COG0697	spore germination
DXY22_02911	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DXY22_02915	COG1191	sigma factor activity
DXY22_02916	COG2172	sigma factor antagonist activity
DXY22_02917	COG1366	Belongs to the anti-sigma-factor antagonist family
DXY22_02918	COG1686	Belongs to the peptidase S11 family
DXY22_02919	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
DXY22_02920	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
DXY22_02921	COG4974	Belongs to the 'phage' integrase family
DXY22_02923	COG0735	belongs to the Fur family
DXY22_02924	COG1300	Membrane
DXY22_02926	COG0281	malic enzyme
DXY22_02927	COG1757	Na H antiporter
DXY22_02928	COG1027	Aspartate ammonia-lyase
DXY22_02929	COG0252	asparaginase activity
DXY22_02930	COG1396	sequence-specific DNA binding
DXY22_02931	COG1379	DNA repair
DXY22_02932	COG0494	nUDIX hydrolase
DXY22_02934	COG0667	Aldo Keto reductase
DXY22_02936	COG1073	alpha beta
DXY22_02938	COG4918	Iron-sulphur cluster biosynthesis
DXY22_02939	COG0456	acetyltransferase
DXY22_02939	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
DXY22_02940	COG2329	Antibiotic biosynthesis monooxygenase
DXY22_02941	COG0456	acetyltransferase
DXY22_02943	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DXY22_02945	COG2211	Major facilitator Superfamily
DXY22_02947	COG0346	lactoylglutathione lyase activity
DXY22_02948	COG1072	(Pantothenic acid kinase))
DXY22_02949	COG3048	D-serine ammonia-lyase activity
DXY22_02950	COG0300	oxidoreductase activity
DXY22_02951	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DXY22_02952	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DXY22_02953	COG4187	Peptidase family M20/M25/M40
DXY22_02954	COG1902	pentaerythritol trinitrate reductase activity
DXY22_02955	COG0596	Alpha beta hydrolase
DXY22_02957	COG1234	tRNA 3'-trailer cleavage
DXY22_02958	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DXY22_02959	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
DXY22_02960	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DXY22_02962	COG0706	membrane insertase activity
DXY22_02963	COG3361	conserved protein (COG2071)
DXY22_02964	COG2195	Cleaves the N-terminal amino acid of tripeptides
DXY22_02965	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DXY22_02966	COG0346	lactoylglutathione lyase activity
DXY22_02968	COG1376	ErfK ybiS ycfS ynhG family protein
DXY22_02969	COG4129	membrane
DXY22_02970	COG1126	abc transporter atp-binding protein
DXY22_02971	COG0765	amino acid transport
DXY22_02972	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DXY22_02974	COG1597	lipid kinase activity
DXY22_02975	COG2814	Major facilitator Superfamily
DXY22_02976	COG0789	Transcriptional regulator
DXY22_02976	COG4978	Transcriptional regulator
DXY22_02977	COG0508	dehydrogenase complex catalyzes the overall conversion of
DXY22_02978	COG0022	dehydrogenase e1 component
DXY22_02979	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DXY22_02980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DXY22_02981	COG3426	butyrate kinase activity
DXY22_02982	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DXY22_02983	COG0280	phosphate acetyltransferase
DXY22_02984	COG3829	transcription factor binding
DXY22_02984	COG3290	protein histidine kinase activity
DXY22_02986	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DXY22_02987	COG2079	MmgE PrpD family protein
DXY22_02988	COG0372	Belongs to the citrate synthase family
DXY22_02989	COG1960	acyl-CoA dehydrogenase activity
DXY22_02990	COG1250	3-hydroxyacyl-CoA dehydrogenase
DXY22_02991	COG0183	Belongs to the thiolase family
DXY22_02992	COG0584	glycerophosphoryl diester phosphodiesterase
DXY22_02993	COG0860	N-Acetylmuramoyl-L-alanine amidase
DXY22_02995	COG1902	pentaerythritol trinitrate reductase activity
DXY22_02997	COG0745	RESPONSE REGULATOR receiver
DXY22_02998	COG0750	zinc metalloprotease
DXY22_02999	COG0497	DNA recombination
DXY22_03000	COG1438	arginine binding
DXY22_03001	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DXY22_03002	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DXY22_03003	COG0142	geranyltranstransferase activity
DXY22_03004	COG1722	exodeoxyribonuclease VII activity
DXY22_03005	COG1570	exodeoxyribonuclease VII activity
DXY22_03006	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DXY22_03007	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DXY22_03008	COG1302	Protein conserved in bacteria
DXY22_03009	COG0439	Biotin carboxylase
DXY22_03010	COG0511	ligase activity, forming carbon-carbon bonds
DXY22_03018	COG3854	ATPases associated with a variety of cellular activities
DXY22_03020	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DXY22_03021	COG0006	proline dipeptidase activity
DXY22_03022	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DXY22_03024	COG3872	metal-dependent enzyme
DXY22_03026	COG1752	Esterase of the alpha-beta hydrolase superfamily
DXY22_03027	COG1321	iron dependent repressor
DXY22_03028	COG0095	Lipoate-protein ligase
DXY22_03029	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DXY22_03030	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DXY22_03031	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DXY22_03032	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DXY22_03033	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
DXY22_03036	COG1396	sequence-specific DNA binding
DXY22_03038	COG0681	Belongs to the peptidase S26 family
DXY22_03043	COG4940	Competence protein ComGF
DXY22_03045	COG4970	Tfp pilus assembly protein FimT
DXY22_03046	COG4537	Required for transformation and DNA binding
DXY22_03047	COG1459	type II secretion system
DXY22_03048	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
DXY22_03050	COG0517	IMP dehydrogenase activity
DXY22_03051	COG0598	Magnesium transport protein CorA
DXY22_03052	COG1253	flavin adenine dinucleotide binding
DXY22_03053	COG1366	Belongs to the anti-sigma-factor antagonist family
DXY22_03055	COG1393	Belongs to the ArsC family
DXY22_03057	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DXY22_03059	COG0011	TIGRFAM Protein of
DXY22_03061	COG2866	Carboxypeptidase
DXY22_03062	COG1368	sulfuric ester hydrolase activity
DXY22_03063	COG1940	carbohydrate kinase activity
DXY22_03064	COG4483	Protein conserved in bacteria
DXY22_03065	COG0457	Tetratricopeptide repeat
DXY22_03065	COG0705	Rhomboid family
DXY22_03067	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DXY22_03069	COG0438	transferase activity, transferring glycosyl groups
DXY22_03072	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DXY22_03073	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DXY22_03074	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DXY22_03075	COG0581	inorganic phosphate transmembrane transporter activity
DXY22_03076	COG0573	inorganic phosphate transmembrane transporter activity
DXY22_03077	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DXY22_03079	COG0477	Major facilitator Superfamily
DXY22_03080	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DXY22_03081	COG2839	Protein conserved in bacteria
DXY22_03082	COG5521	maltodextrose utilization protein MalA
DXY22_03084	COG1388	LysM domain
DXY22_03085	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DXY22_03086	COG4709	membrane
DXY22_03087	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
DXY22_03088	COG0735	belongs to the Fur family
DXY22_03089	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
DXY22_03091	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
DXY22_03092	COG0513	Belongs to the DEAD box helicase family
DXY22_03094	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DXY22_03095	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DXY22_03096	COG2384	SAM-dependent methyltransferase
DXY22_03097	COG2010	Cytochrome c
DXY22_03098	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DXY22_03099	COG0358	DNA primase activity
DXY22_03100	COG1671	Belongs to the UPF0178 family
DXY22_03101	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DXY22_03102	COG0517	IMP dehydrogenase activity
DXY22_03103	COG0751	glycine-tRNA ligase activity
DXY22_03104	COG0752	glycyl-tRNA synthetase alpha subunit
DXY22_03105	COG1381	Involved in DNA repair and RecF pathway recombination
DXY22_03107	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DXY22_03108	COG0295	cytidine deaminase activity
DXY22_03109	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DXY22_03110	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
DXY22_03111	COG1480	7TM receptor with intracellular HD hydrolase
DXY22_03113	COG1702	phosphate starvation-inducible protein PhoH
DXY22_03114	COG0561	phosphatase activity
DXY22_03117	COG4864	UPF0365 protein
DXY22_03118	COG1030	water channel activity
DXY22_03119	COG1610	YqeY-like protein
DXY22_03121	COG1283	sodium-dependent phosphate transmembrane transporter activity
DXY22_03122	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DXY22_03123	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DXY22_03124	COG2264	protein methyltransferase activity
DXY22_03125	COG0484	heat shock protein binding
DXY22_03126	COG0443	Heat shock 70 kDa protein
DXY22_03127	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DXY22_03128	COG1420	regulation of RNA biosynthetic process
DXY22_03129	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DXY22_03130	COG0481	GTPase activity
DXY22_03132	COG0860	N-Acetylmuramoyl-L-alanine amidase
DXY22_03133	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DXY22_03134	COG0268	Binds directly to 16S ribosomal RNA
DXY22_03135	COG1466	dna polymerase III delta subunit
DXY22_03137	COG2333	competence protein COMEC
DXY22_03137	COG0658	competence protein
DXY22_03138	COG2131	deaminase
DXY22_03139	COG1555	photosystem II stabilization
DXY22_03139	COG1596	polysaccharide export
DXY22_03140	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DXY22_03141	COG2226	methyltransferase
DXY22_03142	COG0799	negative regulation of ribosome biogenesis
DXY22_03143	COG1713	HD superfamily hydrolase involved in NAD metabolism
DXY22_03144	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DXY22_03145	COG1534	Rna-binding protein
DXY22_03146	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DXY22_03147	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
DXY22_03148	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
DXY22_03150	COG2755	lipolytic protein G-D-S-L family
DXY22_03151	COG5632	N-Acetylmuramoyl-L-alanine amidase
DXY22_03151	COG3409	Peptidoglycan-binding domain 1 protein
DXY22_03152	COG0398	Pfam SNARE associated Golgi protein
DXY22_03153	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
DXY22_03155	COG3209	COG3209 Rhs family protein
DXY22_03158	COG0477	Major facilitator Superfamily
DXY22_03159	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DXY22_03160	COG4124	Belongs to the glycosyl hydrolase 26 family
DXY22_03163	COG0457	Tetratricopeptide repeat
DXY22_03167	COG5444	nuclease activity
DXY22_03170	COG1309	transcriptional regulator
DXY22_03172	COG5632	N-Acetylmuramoyl-L-alanine amidase
DXY22_03172	COG3409	Peptidoglycan-binding domain 1 protein
DXY22_03172	COG1388	LysM domain
DXY22_03173	COG1783	phage Terminase large subunit
DXY22_03174	COG5484	DNA packaging
DXY22_03175	COG5484	DNA packaging
DXY22_03178	COG3677	Transposase
DXY22_03182	COG0563	adenylate kinase activity
DXY22_03184	COG2856	Zn peptidase
DXY22_03186	COG5002	protein histidine kinase activity
DXY22_03186	COG0642	Histidine kinase
DXY22_03187	COG0745	RESPONSE REGULATOR receiver
DXY22_03188	COG2311	Membrane
DXY22_03189	COG0454	-acetyltransferase
DXY22_03190	COG2249	NAD(P)H dehydrogenase (quinone) activity
DXY22_03192	COG0730	response to heat
DXY22_03193	COG0425	Belongs to the sulfur carrier protein TusA family
DXY22_03194	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DXY22_03194	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DXY22_03195	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DXY22_03195	COG0425	Belongs to the sulfur carrier protein TusA family
DXY22_03196	COG2210	Belongs to the sulfur carrier protein TusA family
DXY22_03197	COG1937	Protein conserved in bacteria
DXY22_03198	COG0662	Cupin 2, conserved barrel domain protein
DXY22_03199	COG4978	Transcriptional regulator
DXY22_03199	COG0789	Transcriptional regulator
DXY22_03200	COG2814	Major facilitator Superfamily
DXY22_03201	COG0456	acetyltransferase
DXY22_03202	COG1253	flavin adenine dinucleotide binding
DXY22_03204	COG0697	spore germination
DXY22_03205	COG0583	DNA-binding transcription factor activity
DXY22_03206	COG2072	flavoprotein involved in K transport
DXY22_03207	COG1230	cation diffusion facilitator family transporter
DXY22_03208	COG1942	4-Oxalocrotonate Tautomerase
DXY22_03209	COG0583	DNA-binding transcription factor activity
DXY22_03210	COG1114	Component of the transport system for branched-chain amino acids
DXY22_03211	COG1687	branched-chain amino acid
DXY22_03212	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DXY22_03213	COG1522	sequence-specific DNA binding
DXY22_03214	COG2732	(Barnase) inhibitor
DXY22_03215	COG2124	cytochrome p450
DXY22_03216	COG1335	isochorismatase
DXY22_03218	COG2318	DinB family
DXY22_03220	COG2070	2-Nitropropane dioxygenase
DXY22_03221	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DXY22_03224	COG3443	Belongs to the bacterial solute-binding protein 9 family
DXY22_03225	COG1595	DNA-templated transcription, initiation
DXY22_03226	COG0667	Aldo Keto reductase
DXY22_03227	COG2851	Citrate transporter
DXY22_03228	COG0583	DNA-binding transcription factor activity
DXY22_03229	COG2828	Protein conserved in bacteria
DXY22_03230	COG3409	Peptidoglycan-binding domain 1 protein
DXY22_03231	COG5566	PFAM Mor transcription activator
DXY22_03232	COG0596	Alpha beta hydrolase
DXY22_03233	COG4991	sh3 domain protein
DXY22_03234	COG4991	sh3 domain protein
DXY22_03236	COG0346	lactoylglutathione lyase activity
DXY22_03238	COG5577	PFAM Coat F domain
DXY22_03239	COG1063	alcohol dehydrogenase
DXY22_03241	COG5577	PFAM Coat F domain
DXY22_03242	COG0789	Transcriptional regulator
DXY22_03244	COG1064	alcohol dehydrogenase
DXY22_03245	COG0693	protein deglycase activity
DXY22_03246	COG1621	beta-fructofuranosidase activity
DXY22_03247	COG3716	PTS system mannose fructose sorbose family IID component
DXY22_03248	COG3715	PTS system
DXY22_03249	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DXY22_03250	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DXY22_03251	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
DXY22_03251	COG3933	PFAM sigma-54 factor interaction domain-containing protein
DXY22_03252	COG1113	amino acid transport
DXY22_03253	COG1280	lysine exporter protein (LysE YggA)
DXY22_03254	COG1378	Sugar-specific transcriptional regulator TrmB
DXY22_03255	COG1595	DNA-templated transcription, initiation
DXY22_03257	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
DXY22_03257	COG2755	lipolytic protein G-D-S-L family
DXY22_03259	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DXY22_03259	COG2124	cytochrome p450
DXY22_03260	COG1309	transcriptional regulator
DXY22_03261	COG2226	methyltransferase
DXY22_03264	COG2116	formate transmembrane transporter activity
DXY22_03266	COG5609	conserved protein (DUF2294)
DXY22_03267	COG3383	formate dehydrogenase (NAD+) activity
DXY22_03268	COG2427	Protein of unknown function (DUF1641)
DXY22_03270	COG0626	cystathionine gamma-synthase activity
DXY22_03271	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DXY22_03272	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DXY22_03273	COG2226	methyltransferase
DXY22_03276	COG0768	penicillin binding
DXY22_03277	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DXY22_03278	COG0572	uridine kinase
DXY22_03281	COG4122	O-methyltransferase activity
DXY22_03282	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DXY22_03283	COG3906	Belongs to the UPF0473 family
DXY22_03284	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
DXY22_03285	COG4472	Bacterial protein of unknown function (DUF965)
DXY22_03286	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DXY22_03287	COG0628	permease
DXY22_03288	COG1126	abc transporter atp-binding protein
DXY22_03289	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DXY22_03290	COG0765	amino acid transport
DXY22_03291	COG0765	amino acid transport
DXY22_03294	COG3881	PFAM PRC-barrel domain
DXY22_03295	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DXY22_03296	COG0457	Tetratricopeptide repeat
DXY22_03297	COG0482	sulfurtransferase activity
DXY22_03298	COG1104	cysteine desulfurase activity
DXY22_03299	COG1959	2 iron, 2 sulfur cluster binding
DXY22_03300	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DXY22_03301	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DXY22_03302	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DXY22_03303	COG0124	histidyl-tRNA synthetase
DXY22_03305	COG4991	sh3 domain protein
DXY22_03305	COG3103	Sh3 type 3 domain protein
DXY22_03305	COG0860	N-Acetylmuramoyl-L-alanine amidase
DXY22_03306	COG1490	D-aminoacyl-tRNA deacylase activity
DXY22_03307	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DXY22_03308	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DXY22_03309	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DXY22_03309	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
DXY22_03310	COG5416	Lipopolysaccharide assembly protein A domain
DXY22_03311	COG0490	domain, Protein
DXY22_03312	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DXY22_03312	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DXY22_03314	COG2244	polysaccharide biosynthetic process
DXY22_03315	COG2323	membrane
DXY22_03317	COG1862	Preprotein translocase
DXY22_03318	COG0343	queuine tRNA-ribosyltransferase activity
DXY22_03319	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DXY22_03321	COG2255	four-way junction helicase activity
DXY22_03322	COG0632	four-way junction helicase activity
DXY22_03324	COG2814	Major facilitator Superfamily
DXY22_03325	COG0673	inositol 2-dehydrogenase activity
DXY22_03326	COG2112	serine threonine protein kinase
DXY22_03329	COG1115	amino acid carrier protein
DXY22_03330	COG0217	transcriptional regulatory protein
DXY22_03332	COG1388	LysM domain
DXY22_03333	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
DXY22_03334	COG0157	Belongs to the NadC ModD family
DXY22_03335	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DXY22_03336	COG1104	cysteine desulfurase activity
DXY22_03337	COG1827	regulation of RNA biosynthetic process
DXY22_03338	COG0077	Prephenate dehydratase
DXY22_03339	COG4492	Belongs to the UPF0735 family
DXY22_03340	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DXY22_03341	COG3290	protein histidine kinase activity
DXY22_03342	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DXY22_03343	COG2868	ribosomal protein
DXY22_03344	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DXY22_03345	COG1994	Peptidase M50
DXY22_03346	COG0739	heme binding
DXY22_03347	COG2894	cell division
DXY22_03348	COG0850	regulation of cytokinetic process
DXY22_03349	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
DXY22_03351	COG1077	Cell shape determining protein MreB Mrl
DXY22_03352	COG2003	Belongs to the UPF0758 family
DXY22_03353	COG0424	maF-like protein
DXY22_03355	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DXY22_03356	COG0285	dihydrofolate synthase activity
DXY22_03357	COG0525	valine-tRNA ligase activity
DXY22_03359	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DXY22_03360	COG1388	LysM domain
DXY22_03361	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DXY22_03362	COG0113	porphobilinogen synthase activity
DXY22_03363	COG1587	Uroporphyrinogen-III synthase
DXY22_03364	COG0181	hydroxymethylbilane synthase activity
DXY22_03365	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DXY22_03366	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DXY22_03368	COG0218	Necessary for normal cell division and for the maintenance of normal septation
DXY22_03369	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DXY22_03370	COG0470	DNA polymerase III
DXY22_03370	COG1067	ATP-dependent peptidase activity
DXY22_03371	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DXY22_03372	COG0544	peptidyl-prolyl cis-trans isomerase activity
DXY22_03373	COG0457	Tetratricopeptide repeat
DXY22_03373	COG1477	protein flavinylation
DXY22_03374	COG0066	3-isopropylmalate dehydratase activity
DXY22_03375	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
DXY22_03376	COG0473	3-isopropylmalate dehydrogenase activity
DXY22_03377	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DXY22_03378	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DXY22_03379	COG0440	acetolactate synthase activity
DXY22_03380	COG0028	Belongs to the TPP enzyme family
DXY22_03382	COG0454	-acetyltransferase
DXY22_03383	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
DXY22_03385	COG0622	Phosphoesterase
DXY22_03386	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DXY22_03387	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DXY22_03388	COG5401	PFAM Sporulation and spore germination
DXY22_03389	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DXY22_03390	COG1846	Transcriptional regulator
DXY22_03391	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DXY22_03395	COG5632	N-Acetylmuramoyl-L-alanine amidase
DXY22_03395	COG3409	Peptidoglycan-binding domain 1 protein
DXY22_03407	COG1388	LysM domain
DXY22_03407	COG0791	NLP P60 protein
DXY22_03408	COG5280	Phage tail tape measure protein TP901
DXY22_03408	COG3953	SLT domain
DXY22_03422	COG5484	DNA packaging
DXY22_03429	COG1595	DNA-templated transcription, initiation
DXY22_03444	COG1484	DNA-dependent DNA replication
DXY22_03446	COG3723	Recombinational DNA repair protein, rece pathway
DXY22_03447	COG5377	YqaJ viral recombinase family
DXY22_03453	COG3645	SOS response
DXY22_03453	COG3646	Phage regulatory protein
DXY22_03458	COG3620	sequence-specific DNA binding
DXY22_03460	COG2856	Zn peptidase
DXY22_03461	COG2197	response regulator
DXY22_03462	COG0824	Thioesterase
DXY22_03463	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DXY22_03464	COG1053	succinate dehydrogenase
DXY22_03465	COG2009	succinate dehydrogenase
DXY22_03466	COG1719	4-vinyl reductase, 4VR
DXY22_03467	COG0527	aspartate kinase activity
DXY22_03468	COG0322	excinuclease ABC activity
DXY22_03469	COG3118	belongs to the thioredoxin family
DXY22_03470	COG3534	alpha-L-arabinofuranosidase
DXY22_03472	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DXY22_03473	COG2086	electron transfer activity
DXY22_03474	COG1024	Enoyl-CoA hydratase
DXY22_03475	COG1309	transcriptional regulator
DXY22_03476	COG0318	PFAM AMP-dependent synthetase and ligase
DXY22_03477	COG3766	membrane
DXY22_03478	COG1193	negative regulation of DNA recombination
DXY22_03479	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DXY22_03479	COG1796	DNA polymerase
DXY22_03480	COG1286	toxin biosynthetic process
DXY22_03481	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
DXY22_03482	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DXY22_03483	COG0072	phenylalanine-tRNA ligase activity
DXY22_03483	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DXY22_03484	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DXY22_03485	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DXY22_03487	COG3835	regulator
DXY22_03488	COG0277	FAD linked oxidase domain protein
DXY22_03489	COG0247	lactate metabolic process
DXY22_03490	COG0346	lactoylglutathione lyase activity
DXY22_03491	COG1966	Carbon starvation protein
DXY22_03492	COG3534	alpha-L-arabinofuranosidase
DXY22_03493	COG0395	ABC-type sugar transport system, permease component
DXY22_03494	COG1175	transmembrane transport
DXY22_03495	COG1653	transport
DXY22_03496	COG0371	Dehydrogenase
DXY22_03497	COG0647	UMP catabolic process
DXY22_03498	COG0235	Class ii aldolase
DXY22_03499	COG1069	ribulokinase activity
DXY22_03500	COG2160	L-arabinose isomerase activity
DXY22_03501	COG3507	Belongs to the glycosyl hydrolase 43 family
DXY22_03502	COG1363	Peptidase, m42
DXY22_03504	COG3326	Membrane
DXY22_03505	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DXY22_03506	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DXY22_03507	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DXY22_03509	COG1346	cytolysis
DXY22_03510	COG1380	Effector of murein hydrolase LrgA
DXY22_03511	COG3279	Response regulator of the LytR AlgR family
DXY22_03512	COG3275	phosphorelay sensor kinase activity
DXY22_03513	COG1011	Hydrolase
DXY22_03514	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DXY22_03516	COG0398	Pfam SNARE associated Golgi protein
DXY22_03517	COG1484	DNA-dependent DNA replication
DXY22_03518	COG3611	Membrane attachment protein
DXY22_03519	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DXY22_03520	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
DXY22_03521	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DXY22_03522	COG1733	regulation of RNA biosynthetic process
DXY22_03523	COG2814	Major facilitator Superfamily
DXY22_03524	COG0656	L-ascorbic acid biosynthetic process
DXY22_03525	COG0237	dephospho-CoA kinase activity
DXY22_03526	COG1971	Probably functions as a manganese efflux pump
DXY22_03527	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DXY22_03528	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DXY22_03528	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DXY22_03529	COG5002	protein histidine kinase activity
DXY22_03530	COG0745	RESPONSE REGULATOR receiver
DXY22_03531	COG0039	L-malate dehydrogenase activity
DXY22_03532	COG0538	isocitrate dehydrogenase activity
DXY22_03533	COG0372	Belongs to the citrate synthase family
DXY22_03534	COG2707	UPF0756 membrane protein
DXY22_03535	COG0628	permease
DXY22_03536	COG3030	protein affecting phage T7 exclusion by the F plasmid
DXY22_03537	COG0469	pyruvate kinase activity
DXY22_03538	COG0205	6-phosphofructokinase activity
DXY22_03539	COG0825	malonyl-CoA metabolic process
DXY22_03540	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DXY22_03541	COG0281	malic enzyme
DXY22_03542	COG0587	DNA-directed DNA polymerase activity
DXY22_03546	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
DXY22_03548	COG4109	DRTGG domain
DXY22_03549	COG0730	response to heat
DXY22_03550	COG1473	amidohydrolase
DXY22_03551	COG0196	riboflavin kinase activity
DXY22_03552	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DXY22_03553	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DXY22_03554	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DXY22_03555	COG1126	abc transporter atp-binding protein
DXY22_03556	COG0765	amino acid transport
DXY22_03557	COG0765	amino acid transport
DXY22_03558	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DXY22_03559	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DXY22_03560	COG0454	-acetyltransferase
DXY22_03561	COG0583	DNA-binding transcription factor activity
DXY22_03562	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
DXY22_03563	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_03565	COG0165	Argininosuccinate lyase
DXY22_03566	COG0137	argininosuccinate synthase activity
DXY22_03567	COG0521	Mo-molybdopterin cofactor biosynthetic process
DXY22_03568	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DXY22_03569	COG0827	DNA restriction-modification system
DXY22_03570	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DXY22_03571	COG3874	Sporulation protein YtfJ
DXY22_03573	COG1714	RDD family
DXY22_03574	COG0616	signal peptide processing
DXY22_03575	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DXY22_03576	COG1574	metal-dependent hydrolase with the TIM-barrel fold
DXY22_03577	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DXY22_03579	COG0301	tRNA thio-modification
DXY22_03580	COG1104	cysteine desulfurase activity
DXY22_03581	COG1114	Component of the transport system for branched-chain amino acids
DXY22_03582	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
DXY22_03583	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
DXY22_03584	COG1309	transcriptional regulator
DXY22_03585	COG1956	GAF domain-containing protein
DXY22_03586	COG2203	Gaf domain
DXY22_03586	COG2199	diguanylate cyclase activity
DXY22_03587	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
DXY22_03589	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DXY22_03590	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DXY22_03591	COG0454	-acetyltransferase
DXY22_03592	COG0517	IMP dehydrogenase activity
DXY22_03593	COG0123	including yeast histone deacetylase and acetoin utilization protein
DXY22_03594	COG1360	Flagellar Motor Protein
DXY22_03595	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DXY22_03596	COG1609	Transcriptional regulator
DXY22_03597	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
DXY22_03597	COG1605	Chorismate mutase
DXY22_03598	COG3118	belongs to the thioredoxin family
DXY22_03599	COG4980	gas vesicle protein
DXY22_03600	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
DXY22_03601	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DXY22_03602	COG1674	ftsk spoiiie
DXY22_03603	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DXY22_03604	COG4848	Belongs to the UPF0354 family
DXY22_03605	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY22_03607	COG1363	Peptidase, m42
DXY22_03608	COG5584	Small secreted protein
DXY22_03609	COG0281	malic enzyme
DXY22_03610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DXY22_03611	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DXY22_03613	COG0510	thiamine kinase activity
DXY22_03614	COG1523	belongs to the glycosyl hydrolase 13 family
DXY22_03615	COG1597	lipid kinase activity
DXY22_03617	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DXY22_03618	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DXY22_03619	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DXY22_03620	COG2252	PERMEase
DXY22_03621	COG4473	ABC transporter
DXY22_03622	COG1131	(ABC) transporter
DXY22_03623	COG1349	DNA-binding transcription factor activity
DXY22_03624	COG1187	pseudouridine synthase activity
DXY22_03625	COG2244	polysaccharide biosynthetic process
DXY22_03626	COG2081	HI0933 family
DXY22_03627	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
DXY22_03629	COG5578	integral membrane protein
DXY22_03630	COG0673	inositol 2-dehydrogenase activity
DXY22_03631	COG1653	transport
DXY22_03632	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
DXY22_03633	COG4209	transmembrane transport
DXY22_03634	COG2207	Transcriptional regulator
DXY22_03635	COG1653	transport
DXY22_03636	COG0395	ABC-type sugar transport system, permease component
DXY22_03637	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DXY22_03638	COG2124	cytochrome p450
DXY22_03639	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DXY22_03641	COG0156	8-amino-7-oxononanoate synthase activity
DXY22_03642	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DXY22_03644	COG1073	alpha beta
DXY22_03645	COG1609	Transcriptional regulator
DXY22_03646	COG1653	transport
DXY22_03647	COG1175	transmembrane transport
DXY22_03648	COG0395	ABC-type sugar transport system, permease component
DXY22_03649	COG1486	melibiose metabolic process
DXY22_03650	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DXY22_03651	COG0495	leucyl-tRNA aminoacylation
DXY22_03653	COG1366	Belongs to the anti-sigma-factor antagonist family
DXY22_03653	COG2202	Pas domain
DXY22_03654	COG2814	Major facilitator Superfamily
DXY22_03655	COG2433	Pfam Transposase IS66
DXY22_03656	COG0577	efflux transmembrane transporter activity
DXY22_03657	COG1136	(ABC) transporter
DXY22_03658	COG2205	protein histidine kinase activity
DXY22_03659	COG0745	RESPONSE REGULATOR receiver
DXY22_03660	COG0577	efflux transmembrane transporter activity
DXY22_03661	COG1136	(ABC) transporter
DXY22_03664	COG1131	(ABC) transporter
DXY22_03665	COG1725	Transcriptional regulator
DXY22_03668	COG1242	4 iron, 4 sulfur cluster binding
DXY22_03669	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
DXY22_03671	COG2267	carboxylic ester hydrolase activity
DXY22_03672	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DXY22_03673	COG1113	amino acid transport
DXY22_03674	COG0367	asparagine synthase
DXY22_03675	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DXY22_03676	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
DXY22_03678	COG1506	peptidase
DXY22_03679	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DXY22_03680	COG1116	anion transmembrane transporter activity
DXY22_03681	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DXY22_03682	COG0494	nUDIX hydrolase
DXY22_03683	COG4824	toxin secretion phage lysis holin
DXY22_03684	COG0783	Belongs to the Dps family
DXY22_03687	COG1854	S-ribosylhomocysteine lyase activity
DXY22_03688	COG0288	reversible hydration of carbon dioxide
DXY22_03689	COG0254	rRNA binding
DXY22_03690	COG1271	oxidase subunit
DXY22_03691	COG1294	oxidase, subunit
DXY22_03693	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DXY22_03694	COG1321	iron dependent repressor
DXY22_03694	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DXY22_03695	COG1121	(ABC) transporter
DXY22_03696	COG0803	Belongs to the bacterial solute-binding protein 9 family
DXY22_03697	COG4948	Mandelate Racemase Muconate Lactonizing
DXY22_03698	COG0318	PFAM AMP-dependent synthetase and ligase
DXY22_03699	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DXY22_03700	COG0596	Alpha beta hydrolase
DXY22_03701	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
DXY22_03702	COG1169	isochorismate synthase
DXY22_03703	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DXY22_03704	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DXY22_03705	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
DXY22_03706	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DXY22_03707	COG0438	transferase activity, transferring glycosyl groups
DXY22_03709	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DXY22_03710	COG0438	transferase activity, transferring glycosyl groups
DXY22_03711	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DXY22_03712	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
DXY22_03713	COG0058	SHG alpha-glucan phosphorylase activity
DXY22_03714	COG0297	glycogen (starch) synthase activity
DXY22_03715	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DXY22_03716	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
DXY22_03717	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
DXY22_03742	COG3859	Proton-coupled thiamine transporter YuaJ
DXY22_03743	COG1247	-acetyltransferase
DXY22_03744	COG2268	Band 7 protein
DXY22_03745	COG1585	Membrane protein implicated in regulation of membrane protease activity
DXY22_03746	COG2318	DinB family
DXY22_03748	COG1454	alcohol dehydrogenase
DXY22_03749	COG1012	belongs to the aldehyde dehydrogenase family
DXY22_03750	COG1510	regulation of RNA biosynthetic process
DXY22_03752	COG0569	domain protein
DXY22_03753	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DXY22_03754	COG4682	membrane
DXY22_03755	COG1705	Flagellar rod assembly protein muramidase FlgJ
DXY22_03756	COG0477	Major facilitator Superfamily
DXY22_03757	COG5553	Cysteine dioxygenase type I
DXY22_03759	COG1968	undecaprenyl-diphosphatase activity
DXY22_03760	COG0628	permease
DXY22_03761	COG0673	inositol 2-dehydrogenase activity
DXY22_03762	COG4806	L-rhamnose isomerase
DXY22_03763	COG3254	rhamnose metabolic process
DXY22_03764	COG1070	Carbohydrate kinase
DXY22_03765	COG1349	DNA-binding transcription factor activity
DXY22_03766	COG3347	Dehydrogenase
DXY22_03766	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_03767	COG0840	transmembrane signaling receptor activity
DXY22_03768	COG0840	transmembrane signaling receptor activity
DXY22_03769	COG0840	transmembrane signaling receptor activity
DXY22_03770	COG0840	transmembrane signaling receptor activity
DXY22_03773	COG0432	Pfam Uncharacterised protein family UPF0047
DXY22_03774	COG0366	Alpha amylase catalytic
DXY22_03775	COG1253	flavin adenine dinucleotide binding
DXY22_03776	COG2738	Putative neutral zinc metallopeptidase
DXY22_03779	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DXY22_03782	COG0166	Belongs to the GPI family
DXY22_03783	COG1979	alcohol dehydrogenase
DXY22_03784	COG1979	alcohol dehydrogenase
DXY22_03785	COG2155	Conserved Protein
DXY22_03786	COG1098	S1 RNA binding domain
DXY22_03787	COG0436	Aminotransferase
DXY22_03788	COG1522	sequence-specific DNA binding
DXY22_03789	COG2267	carboxylic ester hydrolase activity
DXY22_03791	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
DXY22_03792	COG2205	protein histidine kinase activity
DXY22_03794	COG5018	Exonuclease
DXY22_03796	COG2814	Major facilitator Superfamily
DXY22_03797	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
DXY22_03798	COG3011	Protein conserved in bacteria
DXY22_03800	COG3290	protein histidine kinase activity
DXY22_03801	COG4565	transcriptional regulatory protein
DXY22_03806	COG3493	citrate carrier protein
DXY22_03808	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DXY22_03808	COG2111	Na H antiporter
DXY22_03809	COG2111	Na H antiporter
DXY22_03810	COG1006	Multisubunit Na H antiporter MnhC subunit
DXY22_03811	COG0651	ATP synthesis coupled electron transport
DXY22_03812	COG1863	multisubunit Na H antiporter MnhE subunit
DXY22_03813	COG2212	antiporter activity
DXY22_03814	COG1320	monovalent cation:proton antiporter activity
DXY22_03815	COG2050	protein possibly involved in aromatic compounds catabolism
DXY22_03816	COG2197	response regulator
DXY22_03817	COG4585	Histidine kinase
DXY22_03819	COG0142	geranyltranstransferase activity
DXY22_03822	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
DXY22_03823	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
DXY22_03824	COG1335	isochorismatase
DXY22_03825	COG5506	Protein of unknown function (DUF1694)
DXY22_03828	COG0628	permease
DXY22_03831	COG1418	mRNA catabolic process
DXY22_03832	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_03834	COG1511	domain protein
DXY22_03835	COG1674	ftsk spoiiie
DXY22_03835	COG0433	COG0433 Predicted ATPase
DXY22_03836	COG4499	WXG100 protein secretion system (Wss), protein YukC
DXY22_03837	COG5417	Belongs to the EsaB family
DXY22_03838	COG4842	Belongs to the WXG100 family
DXY22_03839	COG2508	Transcriptional regulator
DXY22_03839	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
DXY22_03840	COG0686	Belongs to the AlaDH PNT family
DXY22_03841	COG5634	Uncharacterized conserved protein (DUF2278)
DXY22_03842	COG3251	PFAM MbtH domain protein
DXY22_03843	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DXY22_03844	COG1535	isochorismatase
DXY22_03844	COG3433	isochorismatase activity
DXY22_03845	COG1021	2,3-dihydroxybenzoate-AMP ligase
DXY22_03846	COG1169	isochorismate synthase
DXY22_03847	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_03848	COG2819	hydrolase of the alpha beta superfamily
DXY22_03849	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DXY22_03850	COG1268	BioY protein
DXY22_03851	COG2056	Na+-H+ antiporter family
DXY22_03852	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DXY22_03853	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
DXY22_03854	COG3584	3D domain protein
DXY22_03856	COG1252	NADH dehydrogenase
DXY22_03857	COG0492	ferredoxin-NADP+ reductase activity
DXY22_03859	COG0516	GMP reductase activity
DXY22_03860	COG2808	Putative FMN-binding domain
DXY22_03861	COG0456	acetyltransferase
DXY22_03862	COG0316	Belongs to the HesB IscA family
DXY22_03863	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DXY22_03864	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
DXY22_03865	COG4844	belongs to the
DXY22_03866	COG1252	NADH dehydrogenase
DXY22_03867	COG4837	Protein of unknown function (DUF1462)
DXY22_03868	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DXY22_03869	COG1506	peptidase
DXY22_03869	COG0823	Involved in the tonB-independent uptake of proteins
DXY22_03869	COG4946	Tricorn protease homolog
DXY22_03870	COG0083	homoserine kinase activity
DXY22_03871	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DXY22_03872	COG0460	homoserine dehydrogenase
DXY22_03873	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
DXY22_03874	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DXY22_03875	COG0647	UMP catabolic process
DXY22_03876	COG2445	Protein of unknown function DUF86
DXY22_03877	COG4470	Protein conserved in bacteria
DXY22_03879	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DXY22_03880	COG0739	heme binding
DXY22_03882	COG3377	Domain of unknown function (DUF1805)
DXY22_03883	COG0737	Belongs to the 5'-nucleotidase family
DXY22_03884	COG0730	response to heat
DXY22_03885	COG1801	Protein of unknown function DUF72
DXY22_03887	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DXY22_03888	COG2508	Transcriptional regulator
DXY22_03889	COG2233	PERMEase
DXY22_03890	COG2233	PERMEase
DXY22_03891	COG3195	allantoin biosynthetic process
DXY22_03891	COG3648	Uricase
DXY22_03892	COG3195	allantoin biosynthetic process
DXY22_03892	COG3648	Uricase
DXY22_03893	COG2351	hydroxyisourate hydrolase activity
DXY22_03894	COG2080	2 iron, 2 sulfur cluster binding
DXY22_03895	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DXY22_03896	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DXY22_03897	COG2068	MobA-Related Protein
DXY22_03898	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
DXY22_03900	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DXY22_03901	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DXY22_03902	COG2356	endonuclease I
DXY22_03903	COG3842	ATPase activity
DXY22_03904	COG2188	Transcriptional regulator
DXY22_03905	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DXY22_03906	COG0395	ABC-type sugar transport system, permease component
DXY22_03907	COG1175	transmembrane transport
DXY22_03908	COG1653	transport
DXY22_03909	COG2222	sugar isomerase
DXY22_03910	COG0322	excinuclease ABC activity
DXY22_03911	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DXY22_03914	COG0346	lactoylglutathione lyase activity
DXY22_03915	COG0719	Fe-S assembly protein
DXY22_03916	COG0822	iron-sulfur transferase activity
DXY22_03917	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DXY22_03918	COG0719	Fe-S assembly protein
DXY22_03919	COG0396	ATPase activity
DXY22_03920	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DXY22_03921	COG1464	Belongs to the NlpA lipoprotein family
DXY22_03922	COG2011	ABC-type metal ion transport system permease component
DXY22_03923	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DXY22_03925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DXY22_03926	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
DXY22_03928	COG0509	glycine decarboxylation via glycine cleavage system
DXY22_03929	COG1393	Belongs to the ArsC family
DXY22_03930	COG1960	acyl-CoA dehydrogenase activity
DXY22_03931	COG0183	Belongs to the thiolase family
DXY22_03932	COG1024	Enoyl-CoA hydratase
DXY22_03932	COG1250	3-hydroxyacyl-CoA dehydrogenase
DXY22_03936	COG5577	PFAM Coat F domain
DXY22_03937	COG1846	Transcriptional regulator
DXY22_03938	COG0477	Major facilitator Superfamily
DXY22_03939	COG1942	4-Oxalocrotonate Tautomerase
DXY22_03940	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_03941	COG0583	DNA-binding transcription factor activity
DXY22_03943	COG1120	ATPase activity
DXY22_03946	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_03947	COG0783	Belongs to the Dps family
DXY22_03948	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DXY22_03949	COG0745	RESPONSE REGULATOR receiver
DXY22_03950	COG2770	Histidine kinase
DXY22_03950	COG2205	protein histidine kinase activity
DXY22_03951	COG1309	transcriptional regulator
DXY22_03952	COG0114	fumarate hydratase activity
DXY22_03954	COG0697	spore germination
DXY22_03955	COG0814	amino acid
DXY22_03957	COG2197	response regulator
DXY22_03958	COG4585	Histidine kinase
DXY22_03959	COG4758	membrane
DXY22_03960	COG3595	metallopeptidase activity
DXY22_03961	COG1842	Phage shock protein A
DXY22_03962	COG4758	membrane
DXY22_03963	COG2814	Major facilitator Superfamily
DXY22_03964	COG2096	Adenosyltransferase
DXY22_03965	COG1120	ATPase activity
DXY22_03966	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY22_03967	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DXY22_03968	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_03969	COG3386	PFAM SMP-30 Gluconolaconase
DXY22_03970	COG2205	protein histidine kinase activity
DXY22_03971	COG0745	RESPONSE REGULATOR receiver
DXY22_03973	COG1191	sigma factor activity
DXY22_03975	COG2140	Oxalate decarboxylase
DXY22_03977	COG0577	efflux transmembrane transporter activity
DXY22_03978	COG1136	(ABC) transporter
DXY22_03979	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DXY22_03980	COG1120	ATPase activity
DXY22_03981	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY22_03982	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DXY22_03983	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DXY22_03985	COG0531	amino acid
DXY22_03987	COG1988	membrane-bound metal-dependent
DXY22_03988	COG1368	sulfuric ester hydrolase activity
DXY22_03989	COG1910	domain protein
DXY22_03990	COG0725	ABC transporter, periplasmic molybdate-binding protein
DXY22_03991	COG4149	molybdate abc transporter
DXY22_03992	COG0656	L-ascorbic acid biosynthetic process
DXY22_03994	COG0025	NhaP-type Na H and K H
DXY22_03995	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DXY22_03996	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
DXY22_03997	COG3973	AAA domain
DXY22_03999	COG2860	membrane
DXY22_04000	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
DXY22_04001	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DXY22_04002	COG2217	Heavy metal translocating P-type atpase
DXY22_04003	COG2217	Heavy metal translocating P-type atpase
DXY22_04004	COG2608	mercury ion transmembrane transporter activity
DXY22_04005	COG1937	Protein conserved in bacteria
DXY22_04006	COG0673	inositol 2-dehydrogenase activity
DXY22_04007	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
DXY22_04008	COG1289	transmembrane transporter activity
DXY22_04010	COG2076	Multidrug Resistance protein
DXY22_04011	COG1309	transcriptional regulator
DXY22_04012	COG1028	Short-chain dehydrogenase reductase Sdr
DXY22_04014	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DXY22_04015	COG0557	exoribonuclease II activity
DXY22_04016	COG1647	Serine aminopeptidase, S33
DXY22_04017	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DXY22_04018	COG0596	Alpha beta hydrolase
DXY22_04019	COG1476	TRANSCRIPTIONal
DXY22_04020	COG1396	sequence-specific DNA binding
DXY22_04021	COG1396	sequence-specific DNA binding
DXY22_04022	COG1733	regulation of RNA biosynthetic process
DXY22_04023	COG0840	transmembrane signaling receptor activity
DXY22_04024	COG1174	glycine betaine transport
DXY22_04025	COG1732	Glycine betaine
DXY22_04026	COG1174	glycine betaine transport
DXY22_04027	COG0517	IMP dehydrogenase activity
DXY22_04027	COG1125	glycine betaine transport
DXY22_04028	COG1510	regulation of RNA biosynthetic process
DXY22_04032	COG5658	integral membrane protein
DXY22_04033	COG0640	Transcriptional regulator
DXY22_04034	COG1174	glycine betaine transport
DXY22_04035	COG1732	Glycine betaine
DXY22_04036	COG1174	glycine betaine transport
DXY22_04037	COG1125	glycine betaine transport
DXY22_04037	COG0517	IMP dehydrogenase activity
DXY22_04038	COG1510	regulation of RNA biosynthetic process
DXY22_04039	COG2095	MarC family integral membrane protein
DXY22_04041	COG3064	Membrane
DXY22_04042	COG4640	response to antibiotic
DXY22_04043	COG0456	acetyltransferase
DXY22_04044	COG0148	phosphopyruvate hydratase activity
DXY22_04045	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
DXY22_04046	COG0149	triose-phosphate isomerase activity
DXY22_04047	COG0126	phosphoglycerate kinase activity
DXY22_04048	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DXY22_04049	COG2390	Transcriptional regulator
DXY22_04050	COG2814	Major facilitator Superfamily
DXY22_04051	COG1609	Transcriptional regulator
DXY22_04052	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DXY22_04053	COG0583	DNA-binding transcription factor activity
DXY22_04054	COG0697	spore germination
DXY22_04055	COG1113	amino acid transport
DXY22_04056	COG3858	chitin binding
DXY22_04057	COG1556	Lactate utilization protein
DXY22_04058	COG1139	Iron-sulfur cluster binding protein
DXY22_04059	COG0247	lactate metabolic process
DXY22_04060	COG2197	response regulator
DXY22_04061	COG4585	Histidine kinase
DXY22_04062	COG0842	Transport permease protein
DXY22_04063	COG1131	(ABC) transporter
DXY22_04064	COG0596	Alpha beta hydrolase
DXY22_04065	COG2208	phosphoserine phosphatase activity
DXY22_04066	COG3867	Arabinogalactan endo-beta-1,4-galactanase
DXY22_04067	COG1874	Beta-galactosidase
DXY22_04068	COG3833	ABC-type maltose transport systems, permease component
DXY22_04069	COG1175	transmembrane transport
DXY22_04070	COG2182	Extracellular solute-binding protein
DXY22_04071	COG1609	Transcriptional regulator
DXY22_04072	COG2186	Transcriptional regulator
DXY22_04073	COG1620	l-lactate permease
DXY22_04074	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DXY22_04076	COG5039	Polysaccharide pyruvyl transferase
DXY22_04077	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DXY22_04078	COG0110	maltose O-acetyltransferase activity
DXY22_04079	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DXY22_04080	COG2244	polysaccharide biosynthetic process
DXY22_04081	COG1216	Glycosyl transferase, family 2
DXY22_04082	COG5039	Polysaccharide pyruvyl transferase
DXY22_04083	COG1216	Glycosyl transferase, family 2
DXY22_04085	COG0438	transferase activity, transferring glycosyl groups
DXY22_04086	COG1215	transferase activity, transferring glycosyl groups
DXY22_04087	COG0438	transferase activity, transferring glycosyl groups
DXY22_04088	COG1086	Polysaccharide biosynthesis protein
DXY22_04089	COG0489	protein tyrosine kinase activity
DXY22_04090	COG3944	biosynthesis protein
DXY22_04091	COG1396	sequence-specific DNA binding
DXY22_04092	COG2272	Belongs to the type-B carboxylesterase lipase family
DXY22_04094	COG3479	Phenolic acid decarboxylase
DXY22_04096	COG1794	racemase activity, acting on amino acids and derivatives
DXY22_04097	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
DXY22_04098	COG1621	beta-fructofuranosidase activity
DXY22_04099	COG1621	beta-fructofuranosidase activity
DXY22_04100	COG0531	amino acid
DXY22_04101	COG1309	transcriptional regulator
DXY22_04102	COG2076	Multidrug Resistance protein
DXY22_04103	COG2076	Multidrug Resistance protein
DXY22_04105	COG0277	FAD linked oxidase domain protein
DXY22_04106	COG3621	Patatin-like phospholipase
DXY22_04108	COG0740	serine-type endopeptidase activity
DXY22_04109	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DXY22_04110	COG0366	Alpha amylase catalytic
DXY22_04111	COG1554	hydrolase, family 65, central catalytic
DXY22_04112	COG5521	maltodextrose utilization protein MalA
DXY22_04113	COG3833	ABC-type maltose transport systems, permease component
DXY22_04114	COG1175	transmembrane transport
DXY22_04115	COG2182	Extracellular solute-binding protein
DXY22_04117	COG1609	Transcriptional regulator
DXY22_04118	COG1611	Belongs to the LOG family
DXY22_04119	COG1694	Mazg nucleotide pyrophosphohydrolase
DXY22_04120	COG0659	secondary active sulfate transmembrane transporter activity
DXY22_04121	COG0288	reversible hydration of carbon dioxide
DXY22_04122	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DXY22_04123	COG0577	efflux transmembrane transporter activity
DXY22_04124	COG1136	(ABC) transporter
DXY22_04125	COG5002	protein histidine kinase activity
DXY22_04126	COG0745	RESPONSE REGULATOR receiver
DXY22_04128	COG2162	N-hydroxyarylamine O-acetyltransferase activity
DXY22_04129	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DXY22_04130	COG1481	regulation of sporulation
DXY22_04131	COG0391	Required for morphogenesis under gluconeogenic growth conditions
DXY22_04132	COG1660	Displays ATPase and GTPase activities
DXY22_04133	COG1051	belongs to the nudix hydrolase family
DXY22_04134	COG0492	ferredoxin-NADP+ reductase activity
DXY22_04135	COG3883	PFAM NLP P60 protein
DXY22_04135	COG0791	NLP P60 protein
DXY22_04136	COG0457	Tetratricopeptide repeat
DXY22_04137	COG1132	(ABC) transporter