locus-tag class description C7M26_00001 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C7M26_00002 ENOG4105YHU PTS system C7M26_00003 ENOG4108IQ3 PTS system C7M26_00004 ENOG4105ETZ PTS System C7M26_00005 ENOG4105F3R pts system mannose fructose sorbose family iid C7M26_00006 ENOG4108HKT sucrose-6-phosphate hydrolase C7M26_00007 ENOG4108Z0Z intracellular protease Pfpi family C7M26_00008 ENOG4105DQ4 alcohol dehydrogenase C7M26_00010 ENOG4105VUF Transcriptional regulator C7M26_00013 ENOG4105E2A Dehydrogenase C7M26_00014 ENOG4105PGS Spore coat protein C7M26_00016 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase C7M26_00018 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein C7M26_00019 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein C7M26_00020 ENOG4108VQT Alpha beta hydrolase fold protein C7M26_00021 ENOG4105X5K response regulator receiver protein C7M26_00022 ENOG41083Q9 chitosanase C7M26_00023 ENOG4105C7F AcnD-accessory protein PrpF C7M26_00024 ENOG4108KAM Transcriptional regulator C7M26_00026 ENOG4105CPC Aldo Keto reductase C7M26_00027 ENOG410904A RNA polymerase C7M26_00028 ENOG4108MEK Metal-binding protein YodA C7M26_00029 ENOG4105UNS Pfam:DUF419 C7M26_00032 ENOG4108HHA Transketolase C7M26_00033 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) C7M26_00037 ENOG4107YCY Transcriptional regulator C7M26_00039 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) C7M26_00041 ENOG4105EA8 2-Nitropropane dioxygenase C7M26_00042 ENOG41075D4 Aminoglycoside 6-adenylyltransferase C7M26_00044 ENOG41064BW Protein of unknown function (DUF2568) C7M26_00048 ENOG41067XF inhibitor C7M26_00049 ENOG4108ZRZ Transcriptional regulator (AsnC family) C7M26_00050 ENOG4108UMN azlc family C7M26_00051 ENOG4105KMT branched-chain amino acid C7M26_00054 ENOG41090U3 tautomerase C7M26_00055 ENOG4105PGM cation diffusion facilitator family transporter C7M26_00056 ENOG4105H3G oxidoreductase C7M26_00057 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family C7M26_00060 ENOG4105C37 (CBS) domain C7M26_00063 ENOG41090E6 transcriptional regulator MERR family C7M26_00064 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein C7M26_00065 ENOG4105XTG Pfam:DUF156 C7M26_00066 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase C7M26_00067 ENOG4105VFE sira family C7M26_00069 ENOG4107TPS domain protein C7M26_00070 ENOG4105VFE sira family C7M26_00071 ENOG41087NI Sulfite exporter TauE/SafE C7M26_00072 ENOG41068VA C7M26_00073 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein C7M26_00074 ENOG4108UYN gCN5-related N-acetyltransferase C7M26_00075 ENOG4105DHF Membrane C7M26_00076 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C7M26_00077 ENOG4108SWU Histidine kinase C7M26_00079 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C7M26_00081 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) C7M26_00083 ENOG41067QW Transcriptional regulator C7M26_00084 ENOG4106A7E Transcriptional regulator C7M26_00090 ENOG4108NF7 phage-type endonuclease C7M26_00091 ENOG4108PNI recT protein C7M26_00095 ENOG4105QBX endodeoxyribonuclease RusA C7M26_00097 ENOG4106129 C7M26_00101 ENOG4105IG6 Phage terminase, large subunit C7M26_00102 ENOG4108MDF Phage Portal Protein C7M26_00103 ENOG4106CGH Phage Mu protein F like protein C7M26_00110 ENOG41060SN C7M26_00113 ENOG4105PQS phage protein C7M26_00114 ENOG4105FR7 XkdM protein, phage-like element PBSX C7M26_00116 ENOG4105MTC XkdN-like protein C7M26_00117 ENOG4108FKH Transglycosylase SLT domain C7M26_00118 ENOG4108WZM domain protein C7M26_00119 ENOG4105X7F C7M26_00121 ENOG4105MFU Protein of unknown function (DUF2634) C7M26_00122 ENOG41066EA baseplate J family protein C7M26_00123 ENOG410906S phage-like element pbsx protein xkdt C7M26_00130 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase C7M26_00134 ENOG41064HX Suppressor of fused protein (SUFU) C7M26_00140 ENOG41085FC arsR family transcriptional regulator C7M26_00141 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase C7M26_00142 ENOG4105D6J arsenicaL-resistance protein C7M26_00143 ENOG4108UXE Protein tyrosine phosphatase C7M26_00144 ENOG4107Y5K Resolvase C7M26_00145 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C7M26_00146 ENOG4105WFK nuclease C7M26_00150 ENOG41080BT SNARE associated Golgi C7M26_00151 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase C7M26_00154 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase C7M26_00155 ENOG4105CQW ribosome biogenesis GTPase YqeH C7M26_00156 ENOG4105E2X shikimate dehydrogenase C7M26_00157 ENOG410812S Rna-binding protein C7M26_00158 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) C7M26_00159 ENOG4108WF2 Metal Dependent Phosphohydrolase C7M26_00161 ENOG4108D32 Methyltransferase C7M26_00163 ENOG4105KQC Competence protein C7M26_00164 ENOG4108UK2 deaminase C7M26_00165 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 C7M26_00167 ENOG4105TQK DNA polymerase iii, delta' subunit C7M26_00168 ENOG41082YS Binds directly to 16S ribosomal RNA C7M26_00169 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) C7M26_00170 ENOG4108ZRV stage ii sporulation protein p C7M26_00172 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) C7M26_00173 ENOG4105CSA Coproporphyrinogen iii oxidase C7M26_00174 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) C7M26_00175 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ C7M26_00176 ENOG4105CFG Acts as a chaperone (By similarity) C7M26_00178 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) C7M26_00179 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) C7M26_00180 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C7M26_00183 ENOG4105KTH gatB Yqey C7M26_00184 ENOG4105F7J membrane-bound serine protease C7M26_00185 ENOG4105DI5 UPF0365 protein C7M26_00187 ENOG41068P3 sporulation protein YqfC C7M26_00188 ENOG4105EI1 sporulation protein yqfd C7M26_00189 ENOG4105C9A Phoh family C7M26_00191 ENOG4105CTJ Metal Dependent Phosphohydrolase C7M26_00192 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) C7M26_00193 ENOG4107YR5 Diacylglycerol kinase C7M26_00194 ENOG4105KG3 cytidine deaminase C7M26_00195 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) C7M26_00197 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) C7M26_00198 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit C7M26_00199 ENOG4105C38 Glycyl-tRNA synthetase beta subunit C7M26_00201 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) C7M26_00202 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 C7M26_00203 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) C7M26_00204 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C7M26_00207 ENOG4105EGD dinuclear metal center protein, YbgI family C7M26_00208 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) C7M26_00211 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) C7M26_00212 ENOG41069ZM Protein of unknown function (DUF2624) C7M26_00213 ENOG4108JYZ YitT family C7M26_00214 ENOG4105N80 Ferric uptake regulator, Fur family C7M26_00215 ENOG4108U5J '-nucleotidase C7M26_00216 ENOG41063Y9 C7M26_00217 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) C7M26_00221 ENOG4105SXS Protein of unknown function (DUF456) C7M26_00222 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C7M26_00224 ENOG4107RF6 penicillin-binding protein C7M26_00225 ENOG4105CVA phosphate C7M26_00226 ENOG4105C8U phosphate abc transporter C7M26_00227 ENOG4105E2Z phosphate ABC transporter (Permease C7M26_00228 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C7M26_00229 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C7M26_00230 ENOG41068DG YceG-like family C7M26_00235 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase C7M26_00237 ENOG4107ZXI Rhomboid family C7M26_00240 ENOG4105E0M Sulfatase C7M26_00245 ENOG4105C5X domain protein C7M26_00250 ENOG4105C37 (CBS) domain C7M26_00252 ENOG41080XP Cbs domain C7M26_00263 ENOG4105VFR signal peptidase C7M26_00265 ENOG4108IMY Transcriptional regulator C7M26_00268 ENOG4105C0D helicase C7M26_00269 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) C7M26_00270 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor C7M26_00271 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor C7M26_00272 ENOG4105WZW rhodanese family C7M26_00273 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) C7M26_00274 ENOG4105KST dependent repressor C7M26_00277 ENOG4105CBJ Metal-dependent enzyme C7M26_00279 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) C7M26_00280 ENOG4105DC7 peptidase M24 C7M26_00281 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) C7M26_00283 ENOG4105CD2 stage iii sporulation protein aa C7M26_00284 ENOG4105KR5 Stage iii sporulation protein C7M26_00285 ENOG4108CQH stage III sporulation protein AC C7M26_00286 ENOG4105KQ4 Stage iii sporulation protein ad C7M26_00288 ENOG410644B Stage III sporulation protein af C7M26_00292 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C7M26_00293 ENOG4108ZSR alkaline shock protein C7M26_00294 ENOG4105M7K Involved in the transcription termination process (By similarity) C7M26_00295 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) C7M26_00296 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C7M26_00297 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C7M26_00298 ENOG4105CTB Polyprenyl synthetase C7M26_00300 ENOG4105DX0 Hemolysin A C7M26_00301 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) C7M26_00302 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) C7M26_00303 ENOG4105S1Z Stage IV sporulation protein B C7M26_00304 ENOG4107QQR Sporulation C7M26_00306 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C7M26_00308 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C7M26_00309 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C7M26_00311 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C7M26_00312 ENOG4105C1G acyl-Coa dehydrogenase C7M26_00314 ENOG4105DXD 2-methylcitrate dehydratase C7M26_00315 ENOG4105CR4 methylisocitrate lyase C7M26_00316 ENOG4106CCJ Protein of unknown function (DUF2627) C7M26_00317 ENOG4108JUB Transcriptional regulator C7M26_00319 ENOG4107RDP Dehydrogenase C7M26_00320 ENOG4105CKM Branched-chain carboxylic acid kinase C7M26_00323 ENOG4105CPP Dehydrogenase, E1 component C7M26_00324 ENOG4105C7S Dehydrogenase C7M26_00327 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) C7M26_00328 ENOG4108Y6J UPF0403 protein C7M26_00329 ENOG4108HW3 (ABC) transporter C7M26_00330 ENOG4105E5Q amino acid AbC transporter C7M26_00331 ENOG4105CDA abc transporter atp-binding protein C7M26_00332 ENOG4108QEG Membrane C7M26_00333 ENOG4108VZI ErfK ybiS ycfS ynhG family protein C7M26_00335 ENOG4108ZVT methylmalonyl-coA epimerase C7M26_00336 ENOG4108HNZ carboxyl transferase C7M26_00337 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) C7M26_00338 ENOG4108NA0 Uncharacterized conserved protein (COG2071) C7M26_00339 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) C7M26_00341 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C7M26_00342 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) C7M26_00343 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase C7M26_00344 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) C7M26_00346 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C7M26_00348 ENOG4105II7 pyrroline-5-carboxylate reductase C7M26_00349 ENOG41069FQ Metallo-beta-lactamase superfamily C7M26_00350 ENOG4108IXY short-chain dehydrogenase reductase C7M26_00353 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase C7M26_00355 ENOG4105E5W Transporter C7M26_00357 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C7M26_00359 ENOG4108XET gCN5-related N-acetyltransferase C7M26_00360 ENOG4105KAC Antibiotic biosynthesis monooxygenase C7M26_00361 ENOG4105RHY Pfam:UPF0157 C7M26_00362 ENOG4106HZJ C7M26_00366 ENOG4105CPC Aldo Keto reductase C7M26_00368 ENOG4108YZ4 nudix hydrolase C7M26_00370 ENOG4108IMY Transcriptional regulator C7M26_00371 ENOG4105HDK L-asparaginase C7M26_00372 ENOG4108IJ0 Aspartate ammonia-lyase C7M26_00373 ENOG4105DFD Na H antiporter C7M26_00376 ENOG4105MZ9 stage II sporulation protein m C7M26_00377 ENOG4105I3K Ferric uptake regulator, Fur family C7M26_00379 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C7M26_00380 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) C7M26_00381 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) C7M26_00382 ENOG4105DZ1 carboxypeptidase C7M26_00383 ENOG41082AN stage II sporulation protein C7M26_00384 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) C7M26_00385 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C7M26_00388 ENOG41090VF Stage v sporulation protein ac C7M26_00389 ENOG4105CZ3 stage V sporulation protein ad C7M26_00391 ENOG4105G6R Stage v sporulation protein ae C7M26_00393 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) C7M26_00394 ENOG4105PTM secreted protein C7M26_00395 ENOG4107ZE5 PPIases accelerate the folding of proteins C7M26_00399 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) C7M26_00400 ENOG4105C3F Signal peptidase i C7M26_00402 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) C7M26_00403 ENOG4108R6K riboflavin synthase, subunit alpha C7M26_00404 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) C7M26_00405 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) C7M26_00408 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) C7M26_00409 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) C7M26_00411 ENOG4105DZ1 carboxypeptidase C7M26_00412 ENOG4108JIC nucleoside recognition domain protein C7M26_00414 ENOG4105FE9 pseudouridine synthase C7M26_00416 ENOG4107TWT Cytochrome c biogenesis protein C7M26_00417 ENOG4105CRE cytochrome C C7M26_00418 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C7M26_00419 ENOG4105BZU Histidine kinase C7M26_00422 ENOG4105FF2 Type I DHQase C7M26_00423 ENOG4108JQ1 Dehydrogenase C7M26_00424 ENOG4108SAX Membrane C7M26_00426 ENOG4105T7X C7M26_00427 ENOG4105C9U ATP-dependent DNA helicase RecQ C7M26_00428 ENOG4105I7S Abortive infection protein C7M26_00431 ENOG4107RGJ metallophosphoesterase C7M26_00434 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase C7M26_00435 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) C7M26_00437 ENOG4105MSI germination protein ypeb C7M26_00440 ENOG4105CAT Cytidine monophosphate kinase C7M26_00441 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) C7M26_00442 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) C7M26_00445 ENOG4105S2F C7M26_00446 ENOG41065D1 C7M26_00447 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) C7M26_00448 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase C7M26_00451 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) C7M26_00452 ENOG4105K70 DNA-binding protein C7M26_00453 ENOG4105EUJ GTP cyclohydrolase i C7M26_00455 ENOG4105XXQ heptaprenyl diphosphate synthase component I C7M26_00456 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) C7M26_00457 ENOG4105EAH synthase C7M26_00458 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) C7M26_00459 ENOG4105BZU Histidine kinase C7M26_00460 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase C7M26_00461 ENOG4105D49 3-dehydroquinate synthase C7M26_00462 ENOG4105KHN chorismate mutase C7M26_00463 ENOG4105CRQ synthase (Component I) C7M26_00464 ENOG4108I0Q anthranilate phosphoribosyltransferase C7M26_00466 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase C7M26_00467 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) C7M26_00469 ENOG4105CIH Imidazole acetol-phosphate transaminase C7M26_00471 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase C7M26_00472 ENOG41068YB TPR repeat-containing protein C7M26_00476 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) C7M26_00480 ENOG4108JYZ YitT family C7M26_00481 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase C7M26_00482 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) C7M26_00483 ENOG4108Z5K methylglyoxal synthase C7M26_00484 ENOG4105FJR Lmbe family C7M26_00485 ENOG4105CPK Glycosyl transferase (Group 1 C7M26_00486 ENOG4105DJ0 Poly(A) Polymerase C7M26_00487 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase C7M26_00488 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) C7M26_00489 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) C7M26_00490 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) C7M26_00491 ENOG4105DVT helicase C7M26_00492 ENOG4105YAC C7M26_00494 ENOG4105CHM Aminotransferase C7M26_00495 ENOG4105C5S asparaginyl-tRNA synthetase C7M26_00497 ENOG4105CSM endonuclease III C7M26_00499 ENOG4105BZ4 penicillin-binding protein C7M26_00509 ENOG4108I5C dEAD DEAH box helicase C7M26_00510 ENOG4107X2U Inherit from COG: Exonuclease-like protein C7M26_00511 ENOG4108UKS UPF0398 protein C7M26_00513 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) C7M26_00515 ENOG4105DVT helicase C7M26_00516 ENOG4105CHR reductase C7M26_00518 ENOG4108M60 Transcriptional regulator C7M26_00519 ENOG4105D7K pfkb domain protein C7M26_00520 ENOG4108UHU Aldolase C7M26_00521 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) C7M26_00522 ENOG4105CTD carboxy-peptidase C7M26_00523 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) C7M26_00524 ENOG4105C2W permease C7M26_00525 ENOG41065KQ synthase C7M26_00527 ENOG410890F Dynamin family C7M26_00532 ENOG41081VK Ribonuclease C7M26_00540 ENOG4105CVG Homoserine O-transsuccinylase C7M26_00541 ENOG4108V06 Glutathione peroxidase C7M26_00544 ENOG4105C01 Dihydroxy-acid dehydratase C7M26_00545 ENOG4108Y6J UPF0403 protein C7M26_00546 ENOG4107YX5 Pfam:DUF548 C7M26_00549 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) C7M26_00550 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) C7M26_00552 ENOG4108UT2 hemolysin iii C7M26_00554 ENOG4105C7B Threonine dehydratase C7M26_00556 ENOG4108KF3 Electron transport protein SCO1 SenC C7M26_00557 ENOG41090WU lipolytic protein G-D-S-L family C7M26_00558 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) C7M26_00562 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C7M26_00563 ENOG4105E0X reductase C7M26_00564 ENOG4105C5E polysaccharide biosynthesis protein C7M26_00568 ENOG4107Y9E nuclease C7M26_00571 ENOG4106BHF C7M26_00576 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C7M26_00581 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase C7M26_00583 ENOG4108HQ0 Exopolysaccharide biosynthesis protein C7M26_00587 ENOG4105E4C Lytic transglycosylase catalytic C7M26_00597 ENOG41068G1 C7M26_00619 ENOG4105K70 DNA-binding protein C7M26_00620 ENOG4105ZUG C7M26_00624 ENOG4108NE4 C7M26_00645 ENOG4107D0N C7M26_00662 ENOG4108ZUE Phage regulatory protein rha C7M26_00668 ENOG4105GJD protein, conserved in bacteria C7M26_00678 ENOG4108J9Q DNA ligase C7M26_00679 ENOG4108RAV Conserved protein C7M26_00686 ENOG4105K7W phage-related replication protein C7M26_00691 ENOG4106YR8 C7M26_00692 ENOG41088HM C7M26_00694 ENOG4106PTB DnaB-like helicase C terminal domain C7M26_00695 ENOG4106IVX C7M26_00697 ENOG4106J9J DNA polymerase C7M26_00704 ENOG4105DVF Cytosine-specific methyltransferase C7M26_00720 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) C7M26_00721 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C7M26_00722 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C7M26_00723 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C7M26_00725 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C7M26_00726 ENOG4106ITI Glutaredoxin C7M26_00727 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) C7M26_00733 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) C7M26_00751 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) C7M26_00753 ENOG4105C5E polysaccharide biosynthesis protein C7M26_00754 ENOG4107T32 3-phytase (EC 3.1.3.8) C7M26_00761 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C7M26_00764 ENOG4107S4Y M20 DapE family protein YgeY C7M26_00765 ENOG4108TSC N-acetyltransferase C7M26_00766 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein C7M26_00772 ENOG410841Q phosphoesterase PA-phosphatase related protein C7M26_00773 ENOG4106Z5R C7M26_00775 ENOG4105D3A purine nucleoside phosphorylase DeoD-type C7M26_00776 ENOG4108VXD carboxy-peptidase C7M26_00780 ENOG4105E1V na solute symporter C7M26_00783 ENOG4105FBA Phospholipase Carboxylesterase C7M26_00786 ENOG41090U3 tautomerase C7M26_00787 ENOG4105C6Z Gluconate C7M26_00790 ENOG4105FR1 rard protein C7M26_00794 ENOG4106SCS STAS domain C7M26_00795 ENOG4107QMU Mate efflux family protein C7M26_00798 ENOG41087PP glycosyltransferase MGT family C7M26_00799 ENOG4105K4H Nlp p60 protein C7M26_00801 ENOG4105GMT ATPase associated with various cellular activities aaa_5 C7M26_00802 ENOG4107T89 von Willebrand factor, type A C7M26_00804 ENOG4105C7S Dehydrogenase C7M26_00805 ENOG4105C09 Bile acid C7M26_00806 ENOG4105C8J )-transporter C7M26_00807 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C7M26_00808 ENOG4105EWU Squalene--hopene cyclase C7M26_00809 ENOG4105C26 Dehydrogenase C7M26_00817 ENOG4105SCY DNAK suppressor C7M26_00818 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C7M26_00819 ENOG4105C9U ATP-dependent DNA helicase RecQ C7M26_00820 ENOG41069ER domain protein C7M26_00821 ENOG4108S01 response regulator C7M26_00822 ENOG4108ZGX Histidine kinase C7M26_00823 ENOG4105ECK Fatty Acid Desaturase C7M26_00827 ENOG4108SJC Membrane C7M26_00829 ENOG4105KTU Transcriptional regulator, arsr family C7M26_00831 ENOG4105D29 Helix-turn-helix type 11 domain protein C7M26_00833 ENOG4108W8B Beta-lactamase domain protein C7M26_00835 ENOG4108HJF gCN5-related N-acetyltransferase C7M26_00836 ENOG4105FTV AraC Family Transcriptional Regulator C7M26_00837 ENOG4108Z7R Chaperone CsaA C7M26_00841 ENOG4106BHF C7M26_00842 ENOG4106ANW SMI1_KNR4 C7M26_00844 ENOG4105DB4 C7M26_00847 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C7M26_00848 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C7M26_00850 ENOG410780I phosphoprotein phosphatase activity C7M26_00855 ENOG41079CX C7M26_00856 ENOG4108RAV Conserved protein C7M26_00859 ENOG4108IMY Transcriptional regulator C7M26_00860 ENOG4105YB8 TM2 domain containing protein C7M26_00861 ENOG4107T94 Endo-14-beta-xylanase C7M26_00862 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) C7M26_00866 ENOG4108J4B Beta-lactamase C7M26_00867 ENOG4108V4B ThiJ pfpI C7M26_00869 ENOG4108Q5Y Membrane C7M26_00871 ENOG4105NX3 Membrane C7M26_00872 ENOG4105VMP Transcriptional regulator C7M26_00874 ENOG41073R8 VanW family C7M26_00877 ENOG4105EPI acetyltransferase, (GNAT) family C7M26_00879 ENOG4105F0F Oxalate decarboxylase C7M26_00882 ENOG4108RAV Conserved protein C7M26_00883 ENOG4108NR7 pectate lyase C7M26_00884 ENOG4105XPP Protein of unknown function (DUF1275) C7M26_00885 ENOG4108YQE rare lipoprotein a C7M26_00887 ENOG4105EC8 Methyl-accepting chemotaxis C7M26_00891 ENOG4108J2R molybdopterin oxidoreductase C7M26_00892 ENOG4108M3J Dehydrogenase C7M26_00893 ENOG4107U6E carbohydrate kinase FGGY C7M26_00894 ENOG4105IE8 Alpha-ketoglutarate permease C7M26_00895 ENOG41068WN C7M26_00896 ENOG4108UB7 C7M26_00900 ENOG4105II7 pyrroline-5-carboxylate reductase C7M26_00901 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) C7M26_00902 ENOG4105C5Q Transcriptional regulator C7M26_00903 ENOG4105CBC glutamate synthase C7M26_00904 ENOG4105BZ8 glutamate synthase C7M26_00905 ENOG4105CB2 alcohol dehydrogenase C7M26_00906 ENOG4105SKE transcriptional Regulator LysR family C7M26_00907 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C7M26_00912 ENOG4107QJQ Mate efflux family protein C7M26_00913 ENOG4108N2V aldose 1-epimerase C7M26_00914 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family C7M26_00915 ENOG4105C0W non-ribosomal peptide synthetase C7M26_00917 ENOG4105C0W non-ribosomal peptide synthetase C7M26_00918 ENOG4105CEY Amp-dependent synthetase and ligase C7M26_00920 ENOG4106U2H Protein of unknown function (DUF1360) C7M26_00921 ENOG4105F32 YngK protein C7M26_00923 ENOG4105C1G acyl-Coa dehydrogenase C7M26_00924 ENOG4105CEY Amp-dependent synthetase and ligase C7M26_00925 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C7M26_00926 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit C7M26_00927 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase C7M26_00928 ENOG4105E39 Enoyl-CoA hydratase C7M26_00929 ENOG4107QX3 carboxylase C7M26_00931 ENOG4107T5V SNARE associated Golgi C7M26_00932 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C7M26_00934 ENOG4107SYN Glycosyl hydrolases family 43 C7M26_00935 ENOG4108MYR Secreted protein C7M26_00937 ENOG4107QWR cellulase (EC 3.2.1.4) C7M26_00942 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C7M26_00943 ENOG4105K4P CoA-binding domain protein C7M26_00944 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) C7M26_00945 ENOG4105W8X HesB YadR YfhF-family protein C7M26_00946 ENOG4105MI2 C7M26_00948 ENOG41067CD Small, acid-soluble spore protein Tlp C7M26_00951 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C7M26_00952 ENOG4108I0Z Aconitate hydratase C7M26_00954 ENOG4107DZX Small, acid-soluble spore protein P C7M26_00959 ENOG4107QIV Cytochrome c biogenesis protein C7M26_00963 ENOG4105CV1 Transketolase (EC 2.2.1.1) C7M26_00964 ENOG4105VPS UPF0291 protein C7M26_00965 ENOG4108SVB resolvase C7M26_00967 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) C7M26_00969 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) C7M26_00971 ENOG4105K7W phage-related replication protein C7M26_00973 ENOG4105FVX C7M26_00976 ENOG4108NHD germination protein C7M26_00977 ENOG4108Q8B Spore germination protein C7M26_00992 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) C7M26_00994 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C7M26_00995 ENOG4105C54 Major Facilitator superfamily C7M26_00996 ENOG4107Y9E nuclease C7M26_00997 ENOG4105CMG Carbohydrate kinase C7M26_00998 ENOG4105C93 Xylose Isomerase C7M26_00999 ENOG4105E2R ROK family C7M26_01000 ENOG4105DSG hydrolase family 43 C7M26_01001 ENOG4105CT4 transporter C7M26_01002 ENOG410907G C7M26_01008 ENOG4107AUC C7M26_01012 ENOG41079P0 C7M26_01013 ENOG4105C5F glutamine synthetase C7M26_01014 ENOG4105KV4 Transcriptional regulator C7M26_01015 ENOG4105CXI aluminum resistance protein C7M26_01016 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) C7M26_01017 ENOG4106F1P AAA ATPase, central domain protein C7M26_01018 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C7M26_01019 ENOG4105U6W MutT NUDIX family protein C7M26_01020 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C7M26_01021 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C7M26_01022 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) C7M26_01025 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) C7M26_01026 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) C7M26_01030 ENOG410814C multidrug resistance protein C7M26_01031 ENOG4108X3M OsmC Ohr family protein C7M26_01032 ENOG4105K7W phage-related replication protein C7M26_01034 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C7M26_01037 ENOG4106A3M Cytochrome p-450 C7M26_01039 ENOG4105C0W non-ribosomal peptide synthetase C7M26_01041 ENOG4107SQU synthase C7M26_01042 ENOG4105C0W non-ribosomal peptide synthetase C7M26_01043 ENOG4108KQ6 Enoyl-CoA hydratase C7M26_01044 ENOG4108MGH Enoyl-CoA hydratase C7M26_01045 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase C7M26_01046 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase C7M26_01047 ENOG41062T2 Acyl carrier protein C7M26_01048 ENOG4107QKG PfaD family C7M26_01050 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C7M26_01051 ENOG4108151 Beta-lactamase domain protein C7M26_01052 ENOG4105W1N transcriptional regulator C7M26_01053 ENOG4105IIP Membrane C7M26_01056 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) C7M26_01057 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) C7M26_01060 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C7M26_01061 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) C7M26_01063 ENOG4105MCT stage V sporulation protein S C7M26_01064 ENOG4105D48 metallophosphoesterase C7M26_01065 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) C7M26_01066 ENOG4108A04 Beta-lactamase C7M26_01068 ENOG4105CEV competence damage-inducible protein C7M26_01069 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase C7M26_01072 ENOG4105XZV Protein of unknown function (DUF3243) C7M26_01073 ENOG4108RKS Short-chain dehydrogenase reductase Sdr C7M26_01077 ENOG4105FDP GntR family transcriptional regulator C7M26_01078 ENOG4105CNU cell division protein FtsK C7M26_01080 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit C7M26_01082 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C7M26_01084 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) C7M26_01085 ENOG4108S0H Dipicolinic acid synthetase, b subunit C7M26_01086 ENOG4105E35 Dipicolinate synthase subunit A C7M26_01088 ENOG4105C1V Peptidase, M16 C7M26_01090 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) C7M26_01091 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) C7M26_01092 ENOG4105DTN riboflavin biosynthesis protein ribF C7M26_01093 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) C7M26_01094 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) C7M26_01095 ENOG4105W7A Protein of unknown function (DUF503) C7M26_01096 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) C7M26_01097 ENOG4105VHM ribosomal protein C7M26_01098 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination C7M26_01099 ENOG4105CHV Transcription elongation factor NusA C7M26_01100 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) C7M26_01101 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) C7M26_01102 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) C7M26_01103 ENOG4105DZP Membrane-associated zinc metalloprotease C7M26_01105 ENOG4105KNE Phosphatidate cytidylyltransferase C7M26_01106 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) C7M26_01107 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) C7M26_01109 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) C7M26_01110 ENOG4105CE9 30S ribosomal protein S2 C7M26_01112 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C7M26_01115 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis C7M26_01116 ENOG4105CBS Chea signal transduction histidine kinase C7M26_01117 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) C7M26_01119 ENOG4105FZW flagellar biosynthesis regulator FlhF C7M26_01120 ENOG4105D7B Flagellar biosynthesis protein flha C7M26_01121 ENOG4105D00 flagellar biosynthetic protein flhB C7M26_01122 ENOG4105D19 Role in flagellar biosynthesis (By similarity) C7M26_01123 ENOG4105VS8 Flagellar biosynthetic protein fliq C7M26_01124 ENOG4105CN7 Flagellar biosynthetic protein FliP C7M26_01126 ENOG4107YTP response regulator receiver protein C7M26_01127 ENOG4105DD5 Flagellar motor switch protein C7M26_01128 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C7M26_01130 ENOG4108JQA flagellar C7M26_01131 ENOG410822I Flagellar hook capping protein C7M26_01132 ENOG410696Y Flagellar hook-length control protein C7M26_01134 ENOG4106YF4 Flagellar biosynthesis chaperone C7M26_01137 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C7M26_01138 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) C7M26_01139 ENOG4105VQ0 flagellar hook-basal body complex protein fliE C7M26_01140 ENOG4108ZC9 flagellar basal-body rod protein flgc C7M26_01141 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) C7M26_01143 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) C7M26_01144 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) C7M26_01145 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C7M26_01146 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) C7M26_01147 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) C7M26_01148 ENOG4105C79 DNA protecting protein DprA C7M26_01149 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha C7M26_01150 ENOG4105CMV Succinyl-CoA synthetase subunit beta C7M26_01151 ENOG4105VM1 flagellar C7M26_01153 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C7M26_01154 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) C7M26_01155 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) C7M26_01156 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) C7M26_01157 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) C7M26_01159 ENOG4108BW8 UPF0109 protein C7M26_01160 ENOG4105K5M 30s ribosomal protein S16 C7M26_01162 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) C7M26_01164 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) C7M26_01165 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) C7M26_01166 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) C7M26_01168 ENOG4105CHR reductase C7M26_01169 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C7M26_01171 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) C7M26_01172 ENOG4105CB5 ATP-dependent DNA helicase recG C7M26_01173 ENOG4105EJQ L-serine dehydratase C7M26_01175 ENOG4105DP4 dak2 domain fusion protein ylov C7M26_01176 ENOG4108ZAA Alkaline-shock protein C7M26_01177 ENOG4105VB9 50S ribosomal protein l28 C7M26_01178 ENOG4105FJ0 thiamine C7M26_01179 ENOG4105DJV ribulose-phosphate 3-epimerase C7M26_01180 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) C7M26_01181 ENOG4105D9P serine threonine protein kinase C7M26_01182 ENOG4108ZF3 Phosphatase C7M26_01183 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs C7M26_01184 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B C7M26_01185 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) C7M26_01186 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C7M26_01187 ENOG4105C25 Primosomal protein n' C7M26_01188 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase C7M26_01190 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) C7M26_01191 ENOG4105KC4 UPF0296 protein C7M26_01192 ENOG4105DSJ YicC domain protein C7M26_01195 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein C7M26_01196 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein C7M26_01197 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C7M26_01198 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) C7M26_01199 ENOG4107S4M Sulfate adenylate transferase C7M26_01201 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) C7M26_01203 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) C7M26_01204 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) C7M26_01205 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) C7M26_01206 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) C7M26_01207 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain C7M26_01208 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain C7M26_01210 ENOG4105CXT aspartate transcarbamylase C7M26_01212 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) C7M26_01213 ENOG4105C34 Pseudouridine synthase C7M26_01214 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) C7M26_01216 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) C7M26_01218 ENOG4105DBK s4 domain protein C7M26_01219 ENOG41067XK integral membrane protein C7M26_01220 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) C7M26_01221 ENOG4105DFA alanine racemase domain protein C7M26_01222 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase C7M26_01223 ENOG4105WR5 sporulation protein, YlmC YmxH family C7M26_01225 ENOG4105DKW ABC transporter C7M26_01227 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C7M26_01228 ENOG4105FFI sigma-e processing peptidase spoiiga C7M26_01230 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) C7M26_01231 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) C7M26_01232 ENOG4105K67 small basic protein C7M26_01234 ENOG4108R2U division initiation protein C7M26_01235 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) C7M26_01236 ENOG4105D4A Cell wall formation (By similarity) C7M26_01237 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) C7M26_01238 ENOG4105CNI cell division protein FtsW C7M26_01239 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) C7M26_01240 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) C7M26_01241 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) C7M26_01242 ENOG4105CJN penicillin-binding protein C7M26_01243 ENOG4105CJN penicillin-binding protein C7M26_01245 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) C7M26_01246 ENOG4108V6E Cell division protein mraZ C7M26_01252 ENOG4105KNH Nucleic acid-binding protein C7M26_01254 ENOG4105CDE UPF0348 protein C7M26_01255 ENOG41063PX domain protein C7M26_01256 ENOG4105D78 K07001 NTE family protein C7M26_01257 ENOG4105H20 Sporulation integral membrane protein YlbJ C7M26_01258 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) C7M26_01259 ENOG4106H78 methyltransferase C7M26_01260 ENOG4105WUC UPF0298 protein C7M26_01264 ENOG4106UY4 Inherit from COG: Scp-like extracellular C7M26_01265 ENOG41080XQ Signal transduction protein with cbs domains C7M26_01268 ENOG41064X9 cytochrome C oxidase subunit IV C7M26_01269 ENOG4105CCU oxidase (Subunit III) C7M26_01270 ENOG4105BZ9 Cytochrome C oxidase, subunit I C7M26_01272 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) C7M26_01274 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) C7M26_01275 ENOG4105CNI cell division protein FtsW C7M26_01276 ENOG4105ZPI UPF0358 protein C7M26_01277 ENOG4105CSV Glutaminase C7M26_01279 ENOG4108IAB Phoh family C7M26_01282 ENOG4105QA2 C7M26_01283 ENOG4105CI3 gtp-binding protein typa C7M26_01291 ENOG4105JQZ Methyltransferase C7M26_01293 ENOG4105ECY inositol monophosphatase C7M26_01296 ENOG4105WBI UPF0223 protein C7M26_01297 ENOG4105CXN decarboxylase C7M26_01299 ENOG4107QN2 dihydrolipoyl dehydrogenase C7M26_01300 ENOG4105C7S Dehydrogenase C7M26_01301 ENOG4105CPP Dehydrogenase, E1 component C7M26_01305 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C7M26_01306 ENOG4108X4Q Hydrolase C7M26_01308 ENOG4105CN5 Metallo-Beta-Lactamase C7M26_01310 ENOG4107ZYR domain protein C7M26_01312 ENOG4105BZU Histidine kinase C7M26_01317 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) C7M26_01318 ENOG4105C5H ABC transporter C7M26_01320 ENOG4105C3F Signal peptidase i C7M26_01321 ENOG4105DM4 PTS System C7M26_01322 ENOG4105DE4 1-phosphofructokinase C7M26_01323 ENOG4105E98 transcriptional regulator DeoR family C7M26_01324 ENOG4107RBB ABC transporter, permease C7M26_01325 ENOG4105C19 ABC transporter C7M26_01326 ENOG4107X8C Efflux transporter RND family MFP subunit C7M26_01328 ENOG4105BZ1 (ABC) transporter C7M26_01329 ENOG4105BZ1 (ABC) transporter C7M26_01330 ENOG41067WU Molybdopterin converting factor (Subunit 1) C7M26_01331 ENOG4108ZAF Molybdopterin C7M26_01332 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein C7M26_01333 ENOG4105CVM Molybdenum cofactor synthesis domain protein C7M26_01334 ENOG4105D06 uba thif-type nad fad binding protein C7M26_01335 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) C7M26_01338 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C7M26_01339 ENOG4105D3R alkyl hydroperoxide reductase C7M26_01340 ENOG4105D8X mechanosensitive ion channel C7M26_01342 ENOG4105CH2 amidohydrolase C7M26_01344 ENOG4105NQC Flavodoxin C7M26_01350 ENOG4108XRC Protein of unknown function (DUF458) C7M26_01351 ENOG4107IN1 Protein of unknown function (DUF1797) C7M26_01352 ENOG4105EPM Diguanylate phosphodiesterase C7M26_01354 ENOG4105ESF Peptidoglycan binding domain protein C7M26_01355 ENOG4105K6S Short-chain dehydrogenase reductase Sdr C7M26_01357 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein C7M26_01359 ENOG4105UIN C7M26_01360 ENOG4107R88 Chemotaxis protein (CheV) C7M26_01362 ENOG4105CHM Aminotransferase C7M26_01363 ENOG4105BZU Histidine kinase C7M26_01365 ENOG4105K4I Scp-like extracellular C7M26_01366 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C7M26_01367 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer C7M26_01369 ENOG4105F6S Spore photoproduct lyase C7M26_01371 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) C7M26_01372 ENOG4105KRI phosphocarrier protein (HPr C7M26_01374 ENOG4105CID antiterminator C7M26_01377 ENOG4105DC7 peptidase M24 C7M26_01378 ENOG4105C59 p-type ATPase C7M26_01381 ENOG4105F0V Cell wall hydrolase C7M26_01387 ENOG4105FEA Spore maturation protein C7M26_01388 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr C7M26_01390 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) C7M26_01391 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) C7M26_01392 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase C7M26_01393 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) C7M26_01394 ENOG4108K88 Membrane C7M26_01396 ENOG4105E14 MotA TolQ exbB proton channel C7M26_01397 ENOG4105ER2 Ompa motb domain protein C7M26_01398 ENOG41090MY MarR family Transcriptional regulator C7M26_01399 ENOG4105BZU Histidine kinase C7M26_01403 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) C7M26_01404 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) C7M26_01405 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) C7M26_01406 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit C7M26_01408 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase C7M26_01409 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) C7M26_01410 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) C7M26_01412 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C7M26_01413 ENOG4105BZU Histidine kinase C7M26_01414 ENOG4108TGC Acyltransferase C7M26_01418 ENOG4105D0M Protease HtpX homolog C7M26_01420 ENOG410681C small acid-soluble spore protein C7M26_01422 ENOG4108WZW RNA polymerase sigma C7M26_01423 ENOG4107TS3 membrane protein, TerC C7M26_01424 ENOG4107T5V SNARE associated Golgi C7M26_01425 ENOG4105BZU Histidine kinase C7M26_01426 ENOG4105FDF Could be involved in DNA repair (By similarity) C7M26_01427 ENOG4105DQE DNA ligase C7M26_01436 ENOG4105V75 Transcriptional regulator C7M26_01437 ENOG4105CJW magnesium transporter C7M26_01440 ENOG4106849 propeptide, pepSY amd peptidase M4 C7M26_01442 ENOG41062D9 Histidine kinase C7M26_01443 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C7M26_01444 ENOG4108X43 YKOF domain protein C7M26_01445 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein C7M26_01446 ENOG4108JJB ABC transporter C7M26_01447 ENOG4108W7F transporter, permease C7M26_01449 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C7M26_01450 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) C7M26_01451 ENOG4107Y2X deaminase C7M26_01453 ENOG4108ZHJ Organic hydroperoxide resistance protein C7M26_01454 ENOG4105K56 Transcriptional regulator C7M26_01458 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) C7M26_01459 ENOG4105CIY formyltetrahydrofolate deformylase C7M26_01460 ENOG41080TC multidrug resistance protein C7M26_01462 ENOG4108428 Inherit from COG: -acetyltransferase C7M26_01466 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) C7M26_01467 ENOG4108S4H thioesterase Superfamily protein C7M26_01468 ENOG4107TUM Amidinotransferase C7M26_01469 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) C7M26_01470 ENOG4108JQ7 (ABC) transporter C7M26_01471 ENOG4107SN7 NLP P60 protein C7M26_01472 ENOG4105DTQ mandelate racemase muconate lactonizing C7M26_01473 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A C7M26_01476 ENOG4105C3U ABC transporter C7M26_01477 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C7M26_01478 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C7M26_01479 ENOG4108ME1 Peptidase M55 D-aminopeptidase C7M26_01481 ENOG4105C0H protease C7M26_01483 ENOG4105CKK Glycosyl transferase, family 2 C7M26_01484 ENOG4105EDW glycosyl transferase, family 39 C7M26_01487 ENOG4107R7I amino acid C7M26_01488 ENOG4107GRR phosphate transport regulator C7M26_01489 ENOG4105CJ3 phosphate transporter C7M26_01492 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase C7M26_01498 ENOG41068G1 C7M26_01500 ENOG410906S phage-like element pbsx protein xkdt C7M26_01501 ENOG41066EA baseplate J family protein C7M26_01502 ENOG4105MFU Protein of unknown function (DUF2634) C7M26_01504 ENOG4105X7F C7M26_01505 ENOG4108WZM domain protein C7M26_01506 ENOG4108FKH Transglycosylase SLT domain C7M26_01507 ENOG4105MTC XkdN-like protein C7M26_01508 ENOG4105FR7 XkdM protein, phage-like element PBSX C7M26_01509 ENOG4105PQS phage protein C7M26_01511 ENOG41060SN C7M26_01516 ENOG4108MDF Phage Portal Protein C7M26_01517 ENOG4105IG6 Phage terminase, large subunit C7M26_01518 ENOG4108TFU terminase (Small subunit) C7M26_01527 ENOG410635T phage-like element pbsx protein C7M26_01528 ENOG4105WEF catalase C7M26_01529 ENOG4105K7W phage-related replication protein C7M26_01530 ENOG4105KWG Pfam:DUF1696 C7M26_01531 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase C7M26_01532 ENOG41068K0 YCII-related domain C7M26_01535 ENOG4105JD4 ATPase yjob C7M26_01537 ENOG4107TSN permease C7M26_01538 ENOG4105CTX dehydratase C7M26_01539 ENOG4107QZW Altronate oxidoreductase C7M26_01540 ENOG4107KJX Transcriptional regulator C7M26_01541 ENOG4108I5G Major Facilitator superfamily C7M26_01542 ENOG4105DMW Dehydrogenase reductase C7M26_01543 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) C7M26_01544 ENOG4105CPQ Dehydrogenase C7M26_01545 ENOG4105DG4 malate L-lactate dehydrogenase C7M26_01546 ENOG4105CT4 transporter C7M26_01547 ENOG4105D2H Uronic isomerase C7M26_01550 ENOG4105Q95 Cupin 2, conserved barrel domain protein C7M26_01552 ENOG4108IXI (ABC) transporter C7M26_01553 ENOG4105C4B ABC transporter, permease C7M26_01554 ENOG4105EXQ uroporphyrinogen iii synthase hem4 C7M26_01556 ENOG41087PP glycosyltransferase MGT family C7M26_01557 ENOG4106A3M Cytochrome p-450 C7M26_01562 ENOG4108IEG Formate dehydrogenase Alpha subunit C7M26_01567 ENOG4107CUJ Protein of unknown function (DUF2690) C7M26_01568 ENOG4108ZJ4 polysaccharide deacetylase C7M26_01570 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) C7M26_01573 ENOG4108Z66 YbaK ebsC protein C7M26_01575 ENOG4105VMI -acetyltransferase C7M26_01576 ENOG4105G7B Protein of unknown function (DUF2992) C7M26_01577 ENOG4105DG6 mannose-6-phosphate isomerase C7M26_01578 ENOG4105DM4 PTS System C7M26_01581 ENOG4108PSK reductase C7M26_01589 ENOG4106BHF C7M26_01594 ENOG4105JHY Membrane C7M26_01595 ENOG4105D9U N-acetyltransferase C7M26_01596 ENOG4105C28 cystathionine C7M26_01597 ENOG4105C28 cystathionine C7M26_01599 ENOG4108ZMI UPF0477 protein C7M26_01602 ENOG4105ENA helicase C7M26_01612 ENOG4107A88 C7M26_01613 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH C7M26_01614 ENOG4105DWF phosphomethylpyrimidine kinase C7M26_01615 ENOG4105D06 uba thif-type nad fad binding protein C7M26_01616 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) C7M26_01619 ENOG4108VEU Thiamine monophosphate synthase C7M26_01620 ENOG4105ETU transcriptional activator (TenA C7M26_01623 ENOG4105EMS pseudouridine synthase C7M26_01624 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C7M26_01627 ENOG4105MIX Adenylate cyclase C7M26_01628 ENOG4105E4C Lytic transglycosylase catalytic C7M26_01629 ENOG4108Z18 K06886 hemoglobin C7M26_01630 ENOG4105T58 Dithiol-disulfide isomerase C7M26_01633 ENOG4105DPN Oligoendopeptidase f C7M26_01635 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis C7M26_01636 ENOG4108ZCF integral membrane protein C7M26_01637 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) C7M26_01640 ENOG4108JQ7 (ABC) transporter C7M26_01642 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C7M26_01643 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C7M26_01644 ENOG4108J59 Extracellular solute-binding protein, family 5 C7M26_01645 ENOG4105C31 Tryptophanyl-tRNA synthetase C7M26_01647 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C7M26_01650 ENOG4108JQ7 (ABC) transporter C7M26_01651 ENOG4105C3U ABC transporter C7M26_01653 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C7M26_01654 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C7M26_01657 ENOG4107RMD Basic membrane lipoprotein C7M26_01662 ENOG4105DBV ornithine carbamoyltransferase C7M26_01664 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain C7M26_01665 ENOG4105C8Y Acetylornithine aminotransferase C7M26_01667 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) C7M26_01668 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase C7M26_01670 ENOG4105IQ5 FAD linked oxidase domain protein C7M26_01672 ENOG4105VG1 fes assembly suf system protein C7M26_01673 ENOG4108MXZ Esterase C7M26_01674 ENOG4108KP7 hydrolase C7M26_01676 ENOG41073B9 C7M26_01678 ENOG4107AYK membrAne C7M26_01679 ENOG4105EPR degv family C7M26_01680 ENOG4105D4Y metalloprotease C7M26_01681 ENOG410751J C7M26_01683 ENOG4105K7K Transcriptional regulator C7M26_01687 ENOG4105QNR S1 RNA binding domain protein C7M26_01688 ENOG4108VPT UPF0234 protein C7M26_01690 ENOG4105MA6 gCN5-related N-acetyltransferase C7M26_01691 ENOG4108SZE gCN5-related N-acetyltransferase C7M26_01692 ENOG4107RCC Major Facilitator Superfamily C7M26_01693 ENOG4105DIA mandelate racemase muconate lactonizing C7M26_01695 ENOG41061P3 phosphosulfolactate synthase C7M26_01696 ENOG4108N5B 2-phosphosulfolactate phosphatase C7M26_01697 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) C7M26_01698 ENOG4107RIQ Sulfate adenylate transferase C7M26_01699 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) C7M26_01700 ENOG4107S9D Alpha beta hydrolase C7M26_01701 ENOG4105MYW Pentapeptide repeat protein C7M26_01702 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C7M26_01703 ENOG4108ZUB Lysine exporter protein (Lyse ygga) C7M26_01704 ENOG4105SF0 DinB family C7M26_01705 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) C7M26_01706 ENOG4105ETE Transcriptional regulator (LacI family C7M26_01707 ENOG4106HBX Transcriptional Regulator AraC Family C7M26_01708 ENOG4105UQX Mate efflux family protein C7M26_01711 ENOG4105CAQ asparagine synthetase C7M26_01713 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C7M26_01715 ENOG4105ERH Fumarylacetoacetate hydrolase C7M26_01725 ENOG4105EYH Exonuclease C7M26_01727 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation C7M26_01730 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) C7M26_01731 ENOG4106K7D Major facilitator family transporter C7M26_01732 ENOG4108KK1 membrane protein AbrB duplication C7M26_01735 ENOG4105TRI Hydrolase C7M26_01738 ENOG4108INS Transcriptional regulator C7M26_01739 ENOG4107SCK Monooxygenase C7M26_01742 ENOG41060YP C7M26_01743 ENOG4106CAD Protein of unknown function (DUF3311) C7M26_01744 ENOG4105E1V na solute symporter C7M26_01745 ENOG4105X3H Excalibur domain protein C7M26_01746 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C7M26_01747 ENOG4105XVF Competence transcription factor C7M26_01751 ENOG4106YBV Methyl-accepting chemotaxis C7M26_01752 ENOG4107ZYJ bioY protein C7M26_01753 ENOG4107F3J Amp-dependent synthetase and ligase C7M26_01755 ENOG4107TB6 phosphoglycerate mutase C7M26_01756 ENOG4108HUF Transporter C7M26_01758 ENOG4105KD7 acetyltransferase C7M26_01760 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 C7M26_01762 ENOG4105CEY Amp-dependent synthetase and ligase C7M26_01764 ENOG4105DF9 Lipoate-protein, ligase C7M26_01765 ENOG4108RQ5 Beta-lactamase domain-containing protein C7M26_01768 ENOG4105DER m42 family C7M26_01769 ENOG41090T1 Membrane C7M26_01771 ENOG4105ECB domain protein C7M26_01773 ENOG4105C1Q protoporphyrinogen oxidase C7M26_01774 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) C7M26_01775 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) C7M26_01776 ENOG4105BZ4 penicillin-binding protein C7M26_01777 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation C7M26_01784 ENOG4105K59 histidine triad (HIT) protein C7M26_01785 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) C7M26_01786 ENOG4105NBU tryptophan transport protein C7M26_01792 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C7M26_01794 ENOG4105EQI Metal Dependent Phosphohydrolase C7M26_01795 ENOG4106D4I domain protein C7M26_01796 ENOG4107VRP DNA repair exonuclease C7M26_01797 ENOG4105RHA ABC transporter, permease C7M26_01798 ENOG4108IUX (ABC) transporter C7M26_01800 ENOG4105CGU Enoyl-CoA hydratase C7M26_01802 ENOG4105NCW Trka-c domain protein C7M26_01803 ENOG4107S91 Sodium hydrogen exchanger C7M26_01804 ENOG4105D4P Coproporphyrinogen iii oxidase C7M26_01806 ENOG4105F1N DNA alkylation repair C7M26_01807 ENOG4105WZB UPF0342 protein C7M26_01808 ENOG4106MP8 UPF0754 membrane protein C7M26_01810 ENOG410839P C7M26_01814 ENOG4105BZ1 (ABC) transporter C7M26_01815 ENOG4105BZ1 (ABC) transporter C7M26_01818 ENOG4105F0I Aminotransferase C7M26_01819 ENOG4107VMI polysaccharide deacetylase C7M26_01820 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) C7M26_01821 ENOG4105D64 Mechanosensitive ion channel C7M26_01823 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C7M26_01824 ENOG4105WMR Protein CrcB homolog C7M26_01826 ENOG4105C37 (CBS) domain C7M26_01827 ENOG4105CHM Aminotransferase C7M26_01829 ENOG4105C37 (CBS) domain C7M26_01830 ENOG4105F6E Acyl-transferase C7M26_01831 ENOG4108FN7 Aldo keto reductase C7M26_01832 ENOG4108AEY RNA polymerase sigma factor C7M26_01833 ENOG4105J37 C7M26_01836 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C7M26_01837 ENOG4105C8J )-transporter C7M26_01838 ENOG4105CUB amino acid C7M26_01839 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C7M26_01840 ENOG4105BZN citrate synthase C7M26_01843 ENOG4105G6Z alkaline phosphatase C7M26_01844 ENOG4105ED1 spovr family C7M26_01851 ENOG4105WH1 Two component transcriptional regulator luxr family C7M26_01852 ENOG4105BZU Histidine kinase C7M26_01854 ENOG4105C6V Glycerol-3-phosphate dehydrogenase C7M26_01855 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) C7M26_01857 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator C7M26_01858 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C7M26_01859 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase C7M26_01860 ENOG4107YBY Hydrolase C7M26_01861 ENOG41080XP Cbs domain C7M26_01863 ENOG4108YBP pseudouridine synthase C7M26_01871 ENOG4105BZU Histidine kinase C7M26_01873 ENOG4105VEQ Cold shock protein C7M26_01874 ENOG4108TU7 Inherit from COG: (ABC) transporter C7M26_01875 ENOG4105CJ1 ABC, transporter C7M26_01876 ENOG4105CZV ABC transporter C7M26_01877 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family C7M26_01880 ENOG4105CS1 NAD(P)H quinone oxidoreductase C7M26_01881 ENOG4105C0R drug resistance transporter emrb qaca subfamily C7M26_01882 ENOG4105CW7 secretion protein, HlyD family C7M26_01883 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes C7M26_01884 ENOG4106AKX UPF0229 protein C7M26_01885 ENOG4105CYN Serine protein kinase C7M26_01889 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) C7M26_01891 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) C7M26_01894 ENOG4105VZ8 Transcriptional regulator C7M26_01895 ENOG4107D63 C7M26_01896 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) C7M26_01898 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) C7M26_01899 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component C7M26_01900 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein C7M26_01901 ENOG4105E2Y ABC, transporter C7M26_01904 ENOG4105DNP FAD linked oxidase domain protein C7M26_01905 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) C7M26_01906 ENOG4105EC3 peptidase S51, dipeptidase E C7M26_01908 ENOG4108N23 SpoOM-related protein C7M26_01930 ENOG4105G5W regulator Fur family C7M26_01931 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C7M26_01933 ENOG4107NBY Membrane C7M26_01934 ENOG4105BZ1 (ABC) transporter C7M26_01935 ENOG4105EVI UPF0374 protein C7M26_01938 ENOG4105CAN Short-chain dehydrogenase reductase Sdr C7M26_01939 ENOG4106BXE C7M26_01940 ENOG4105CEN a g-specific adenine glycosylase C7M26_01941 ENOG41067AE Membrane-bound metal-dependent hydrolase C7M26_01942 ENOG4105EJV Membrane C7M26_01943 ENOG4105CKK Glycosyl transferase, family 2 C7M26_01944 ENOG4105D74 hydrolase C7M26_01945 ENOG4106AKJ C7M26_01949 ENOG4105F27 Major Facilitator C7M26_01952 ENOG4105ECP epimerase C7M26_01955 ENOG4107Y03 Nitroreductase C7M26_01956 ENOG4105JAB phenazine biosynthesis protein, phzf family C7M26_01957 ENOG4108IHU transport system permease protein C7M26_01958 ENOG4105DQ5 transport system permease protein C7M26_01959 ENOG4108MES Periplasmic binding protein C7M26_01961 ENOG410834F Transcriptional regulator C7M26_01962 ENOG4105C0R drug resistance transporter emrb qaca subfamily C7M26_01963 ENOG4108YYS metal-dependent hydrolase (By similarity) C7M26_01964 ENOG4107Y80 Major Facilitator superfamily C7M26_01965 ENOG4105YA8 Transcriptional regulator C7M26_01966 ENOG4105H93 Acyltransferase family C7M26_01967 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold C7M26_01968 ENOG4105U3E Transcriptional regulator C7M26_01969 ENOG4108KYE ABC-2 type transporter C7M26_01970 ENOG41090VJ ABC-2 type transporter C7M26_01971 ENOG4105CJ1 ABC, transporter C7M26_01972 ENOG4105WH1 Two component transcriptional regulator luxr family C7M26_01973 ENOG4105BZU Histidine kinase C7M26_01975 ENOG4105CIB oxidoreductase Domain protein C7M26_01976 ENOG4107QP6 Xylose isomerase domain protein TIM barrel C7M26_01977 ENOG4107QNK )-transporter C7M26_01978 ENOG4105ID8 Transcriptional regulator, ARAC family C7M26_01979 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase C7M26_01981 ENOG4105BZ1 (ABC) transporter C7M26_01982 ENOG4105BZ1 (ABC) transporter C7M26_01983 ENOG4105CI1 PTS System C7M26_01984 ENOG4108Q3X Transcriptional regulator C7M26_01985 ENOG4105F8D glycoside hydrolase family 4 C7M26_01991 ENOG4105KK4 UPF0060 membrane protein C7M26_01992 ENOG41069DP small acid-soluble spore protein C7M26_01993 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family C7M26_01995 ENOG4107QKR Dehydrogenase C7M26_01997 ENOG4107RUY (E1 component), alpha subunit C7M26_02002 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C7M26_02004 ENOG4105D7N magnesium and cobalt transport protein CorA C7M26_02005 ENOG4106KE4 Dehydrogenase C7M26_02009 ENOG4105D8X mechanosensitive ion channel C7M26_02011 ENOG4105UPD Calcium Proton C7M26_02012 ENOG4108ISG Major Facilitator C7M26_02014 ENOG4107U9T Pfam:Ribonuclease_BN C7M26_02016 ENOG4105KJF protein tyrosine phosphatase C7M26_02019 ENOG4107RKG DJ-1/PfpI family C7M26_02020 ENOG4105CGH 5'-nucleotidase C7M26_02021 ENOG4108RCM Nitroreductase C7M26_02022 ENOG4107414 GntR family transcriptional regulator C7M26_02023 ENOG4105CG3 alpha amylase, catalytic region C7M26_02024 ENOG4105C5Y PTS System C7M26_02025 ENOG4105E1K spore germination protein C7M26_02026 ENOG4105E1K spore germination protein C7M26_02027 ENOG4108Q5U germination protein, ger(x)c family C7M26_02029 ENOG4105GEU Spore germination protein C7M26_02034 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) C7M26_02038 ENOG4108RPX mosc domain containing protein C7M26_02039 ENOG410855V Acylphosphatase C7M26_02044 ENOG4108MRH transcriptional regulatory protein C7M26_02046 ENOG4107QPK )-transporter C7M26_02047 ENOG4108J20 pectate lyase C7M26_02050 ENOG4108HUF Transporter C7M26_02051 ENOG4105DQ5 transport system permease protein C7M26_02052 ENOG4108U1V ABC transporter, permease C7M26_02053 ENOG4105E0A ABC, transporter C7M26_02054 ENOG4105E6M Sulphatase-modifying factor protein C7M26_02056 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein C7M26_02058 ENOG4105FDU atp-dependent rna helicase C7M26_02059 ENOG4105C5H ABC transporter C7M26_02060 ENOG4105DXB Major Facilitator superfamily C7M26_02061 ENOG4107SWG transcriptional regulator MERR family C7M26_02063 ENOG4105C5H ABC transporter C7M26_02064 ENOG4105FKZ Methyl-accepting chemotaxis C7M26_02065 ENOG4105C26 Dehydrogenase C7M26_02066 ENOG4105CUB amino acid C7M26_02068 ENOG4105EU0 Major facilitator Superfamily C7M26_02069 ENOG41090R9 glycosyltransferase C7M26_02070 ENOG4107R51 Glycosyl transferase, family 2 C7M26_02071 ENOG41090R9 glycosyltransferase C7M26_02073 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase C7M26_02074 ENOG4105E0M Sulfatase C7M26_02075 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C7M26_02076 ENOG4108R1P C7M26_02077 ENOG41061H0 Monooxygenase C7M26_02078 ENOG41082F9 transcriptional regulator C7M26_02079 ENOG4108PCN EamA-like transporter family C7M26_02080 ENOG4106I4J membrane C7M26_02083 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily C7M26_02084 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) C7M26_02085 ENOG4105H67 Protein of unknown function (DUF421) C7M26_02086 ENOG4105F8D glycoside hydrolase family 4 C7M26_02087 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component C7M26_02089 ENOG4105E0S extracellular solute-binding protein family 1 C7M26_02090 ENOG4105EKC C7M26_02092 ENOG4107TDE lipolytic protein G-D-S-L family C7M26_02094 ENOG4105CX8 fg-gap repeat protein C7M26_02095 ENOG4105CX8 fg-gap repeat protein C7M26_02098 ENOG4107TDE lipolytic protein G-D-S-L family C7M26_02099 ENOG41075H3 AraC family transcriptional regulator C7M26_02100 ENOG4105F5H Glycosyl Hydrolase Family 88 C7M26_02101 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component C7M26_02102 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component C7M26_02103 ENOG410769Z extracellular solute-binding protein family 1 C7M26_02104 ENOG4105EQD regulatoR C7M26_02105 ENOG4105C2F Histidine kinase C7M26_02107 ENOG4105M18 -acetyltransferase C7M26_02108 ENOG4105WEF catalase C7M26_02111 ENOG4107S9F NmrA family C7M26_02112 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein C7M26_02113 ENOG4105M4P Tetr family transcriptional regulator C7M26_02115 ENOG4105CDY transcriptional regulatory protein C7M26_02126 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C7M26_02127 ENOG4105CBD Diacylglycerol kinase C7M26_02129 ENOG4108IG5 Transcriptional regulator C7M26_02130 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C7M26_02131 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C7M26_02132 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C7M26_02133 ENOG4105CK7 Sodium proline symporter C7M26_02134 ENOG4105KT7 mgtC SapB transporter C7M26_02135 ENOG4105CRN Aminoglycoside phosphotransferase C7M26_02137 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) C7M26_02138 ENOG4105C4R Atp-dependent dna helicase C7M26_02139 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) C7M26_02140 ENOG4105CBC glutamate synthase C7M26_02141 ENOG4105KGF protein, YerC YecD C7M26_02142 ENOG4108R5T secreted protein C7M26_02145 ENOG4105DVH amino acid C7M26_02147 ENOG4105C12 Phosphoribosylglycinamide synthetase C7M26_02148 ENOG4105DC1 bifunctional purine biosynthesis protein purh C7M26_02149 ENOG4108V3E phosphoribosylglycinamide formyltransferase C7M26_02150 ENOG4105CXB phosphoribosylaminoimidazole synthetase C7M26_02152 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii C7M26_02153 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I C7M26_02154 ENOG4105VR9 phosphoribosylformylglycinamidine synthase C7M26_02155 ENOG4105C8V SAICAR synthetase C7M26_02156 ENOG4105C83 adenylosuccinate lyase C7M26_02157 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit C7M26_02158 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) C7M26_02163 ENOG4105C7N Xanthine uracil vitamin C permease C7M26_02167 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C7M26_02169 ENOG4105C85 amino acid C7M26_02170 ENOG4107STQ Multicopper oxidase C7M26_02172 ENOG4107YUH hydrolase C7M26_02178 ENOG4107QNK )-transporter C7M26_02179 ENOG4108ZMR Ion transport 2 domain-containing protein C7M26_02181 ENOG4108WV1 Pfam:DUF477 C7M26_02182 ENOG4105DQX Zinc finger domain C7M26_02183 ENOG41087YS Phage shock protein A C7M26_02185 ENOG4105CT4 transporter C7M26_02186 ENOG4105CPQ Dehydrogenase C7M26_02187 ENOG4105PGZ NB-ARC domain C7M26_02189 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) C7M26_02191 ENOG4108TYN CAAX amino terminal protease family protein C7M26_02193 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) C7M26_02194 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) C7M26_02195 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) C7M26_02196 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C7M26_02197 ENOG4105C5H ABC transporter C7M26_02198 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C7M26_02199 ENOG410801F ribosomal-protein-alanine acetyltransferase C7M26_02200 ENOG41072GX Peptidase M22 Glycoprotease C7M26_02201 ENOG4105K8N protein family UPF0079, ATPase C7M26_02202 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) C7M26_02211 ENOG4105D3P Mannan endo-1,4-beta-mannosidase C7M26_02212 ENOG4105DG6 mannose-6-phosphate isomerase C7M26_02213 ENOG4105EVU fructokinase C7M26_02214 ENOG4108TZY GntR Family Transcriptional Regulator C7M26_02215 ENOG4105CS2 ec 3.2.1.21 C7M26_02216 ENOG4105CK1 PTS System C7M26_02217 ENOG4105VCP PTS System C7M26_02218 ENOG4105VZJ PTS System C7M26_02219 ENOG4105F27 Major Facilitator C7M26_02220 ENOG41090UD (LipO)protein C7M26_02221 ENOG4107TVP HD domain protein C7M26_02222 ENOG4108YM7 Gcn5-related n-acetyltransferase C7M26_02224 ENOG4108ZMX Domain of unknown function (DU1801) C7M26_02225 ENOG4105G6Z alkaline phosphatase C7M26_02228 ENOG4105VRS hydrolase family 18 C7M26_02229 ENOG4105DRR Transcriptional regulator, GntR family C7M26_02231 ENOG4105C2C drug resistance transporter, Bcr CflA C7M26_02232 ENOG4105FS7 Transcriptional regulator C7M26_02233 ENOG4108TVJ Nitroreductase C7M26_02234 ENOG4105EYF MMPL domain protein C7M26_02235 ENOG41062A4 Transcriptional regulator C7M26_02237 ENOG4105C85 amino acid C7M26_02239 ENOG4105WQG acetyltransferase C7M26_02241 ENOG4105PF9 Transcriptional regulator C7M26_02245 ENOG4108QY0 Membrane C7M26_02246 ENOG410900G Protein of unknown function (DUF421) C7M26_02250 ENOG4105XXY Thioredoxin C7M26_02251 ENOG4108VGI doxx family C7M26_02252 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase C7M26_02253 ENOG4108TVJ Nitroreductase C7M26_02254 ENOG41076HS cation diffusion facilitator family transporter C7M26_02255 ENOG4108Z5V transcriptional regulator, merr family C7M26_02256 ENOG4108UQV Membrane C7M26_02257 ENOG4108WC5 Alpha Beta Hydrolase Fold protein C7M26_02258 ENOG4105EYF MMPL domain protein C7M26_02259 ENOG4108VB1 regulatoR C7M26_02260 ENOG4105ENE Histidine kinase C7M26_02262 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) C7M26_02263 ENOG4108ZHR arsR family transcriptional regulator C7M26_02264 ENOG4108SQ9 flavin reductase domain protein, FMN-binding C7M26_02266 ENOG4107Y9U Membrane C7M26_02267 ENOG4105Z7P Acetyltransferase (GNAT) family C7M26_02268 ENOG4107R5R arsenical pump membrane protein C7M26_02269 ENOG41082YX Transcriptional regulator, arsr family C7M26_02270 ENOG4108JGH Tetr family transcriptional regulator C7M26_02271 ENOG4105EQ0 Major Facilitator superfamily C7M26_02273 ENOG4107Z6X Transcriptional regulator C7M26_02274 ENOG4105MJ9 esterase C7M26_02275 ENOG4108ZMQ domain protein C7M26_02276 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C7M26_02277 ENOG4105T38 integral membrane protein C7M26_02278 ENOG4105ST3 Transcriptional regulator C7M26_02279 ENOG4105KRI phosphocarrier protein (HPr C7M26_02281 ENOG4105GIG C7M26_02282 ENOG4105CZ9 Domain of unknown function (DU1801) C7M26_02284 ENOG4105DXI Major Facilitator superfamily C7M26_02285 ENOG4107U9B transcriptional regulator C7M26_02286 ENOG41086D8 Transcriptional regulator C7M26_02287 ENOG4108UZ3 Transporter C7M26_02288 ENOG4108MCI Transcriptional regulator, ARAC family C7M26_02290 ENOG4108VJ1 Transcriptional regulator (CarD family C7M26_02291 ENOG4105VEQ Cold shock protein C7M26_02292 ENOG4105ECK Fatty Acid Desaturase C7M26_02294 ENOG4105VZ8 Transcriptional regulator C7M26_02295 ENOG4106BHF C7M26_02307 ENOG41064BQ Phosphatase C7M26_02309 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) C7M26_02310 ENOG4105WN5 stage II sporulation protein C7M26_02311 ENOG4107SGM protein serine threonine phosphatase C7M26_02312 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase C7M26_02313 ENOG4105FUA antagonist C7M26_02314 ENOG4107MMM Anti-sigma-factor antagonist C7M26_02315 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) C7M26_02317 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C7M26_02318 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein C7M26_02319 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) C7M26_02321 ENOG4105CKV Membrane C7M26_02322 ENOG410905X membrane-flanked domain protein C7M26_02323 ENOG4105C1J atp-dependent rna helicase C7M26_02324 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) C7M26_02325 ENOG4105CPF Cell wall formation (By similarity) C7M26_02326 ENOG4105SZ6 Thioredoxin C7M26_02330 ENOG4105FDT acyl-CoA dehydrogenase C7M26_02333 ENOG4105CJ1 ABC, transporter C7M26_02334 ENOG4106F5Q Membrane C7M26_02335 ENOG4107QJT sodium dicarboxylate symporter C7M26_02336 ENOG4108MRH transcriptional regulatory protein C7M26_02337 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism C7M26_02338 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit C7M26_02341 ENOG41082W1 Cupin 2, conserved barrel domain protein C7M26_02342 ENOG4105QVS general stress protein C7M26_02343 ENOG4105EU9 C7M26_02344 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) C7M26_02346 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) C7M26_02350 ENOG4105C0X amino acid C7M26_02352 ENOG4107R8N Glycosyl transferase, family 2 C7M26_02353 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) C7M26_02356 ENOG4105C9U ATP-dependent DNA helicase RecQ C7M26_02358 ENOG4105VCH membrane C7M26_02360 ENOG410606W general stress protein C7M26_02363 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C7M26_02364 ENOG4105HMZ Methyltransferase C7M26_02366 ENOG4105ETD TRANSCRIPTIONal C7M26_02367 ENOG4107QM2 Aldo Keto reductase C7M26_02368 ENOG4107RVG penicillin-binding protein C7M26_02369 ENOG41061CK Antibiotic biosynthesis monooxygenase C7M26_02371 ENOG4105XJB lipolytic protein G-D-S-L family C7M26_02372 ENOG4107258 Transcriptional regulator C7M26_02374 ENOG4105P4J Allophanate hydrolase, subunit 1 C7M26_02375 ENOG4105CFM UPF0317 protein C7M26_02376 ENOG4105C5A transporter C7M26_02377 ENOG4105E7W lamb ycsf family protein C7M26_02382 ENOG4108ZX0 Signal peptidase I C7M26_02384 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C7M26_02389 ENOG4108ZYE Transcriptional regulator C7M26_02390 ENOG4108T5E Copper resistance protein C7M26_02391 ENOG4105KTB nuclear export factor GLE1 C7M26_02392 ENOG4105H9W Short-chain dehydrogenase reductase Sdr C7M26_02394 ENOG4105C26 Dehydrogenase C7M26_02395 ENOG4108JPW Aminotransferase C7M26_02397 ENOG4105YVS arsR family transcriptional regulator C7M26_02398 ENOG41067V3 Antibiotic biosynthesis monooxygenase C7M26_02399 ENOG4108DBC nitroreductase C7M26_02400 ENOG4105R8C Transcriptional regulator C7M26_02403 ENOG4108IPW abc transporter atp-binding protein C7M26_02404 ENOG4105CM4 permease protein C7M26_02405 ENOG4105DHS permease protein C7M26_02406 ENOG4105CFH Aspartokinase C7M26_02411 ENOG4105BZU Histidine kinase C7M26_02412 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C7M26_02413 ENOG4107WD8 ABC transporter, permease C7M26_02417 ENOG4105E1K spore germination protein C7M26_02420 ENOG4105DUX Transporter C7M26_02422 ENOG41069ZX C7M26_02423 ENOG41069ZX C7M26_02424 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) C7M26_02425 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase C7M26_02426 ENOG4106P55 Transcriptional regulator C7M26_02428 ENOG4105DRP amino acid AbC transporter C7M26_02429 ENOG4105CDA abc transporter atp-binding protein C7M26_02431 ENOG4105W8Z 4'-phosphopantetheinyl transferase C7M26_02434 ENOG4105SX7 Transporter C7M26_02440 ENOG4105CEY Amp-dependent synthetase and ligase C7M26_02441 ENOG4105KVH Transcriptional regulator C7M26_02442 ENOG4108VA3 3-hexulose-6-phosphate synthase C7M26_02443 ENOG41080HJ 6-phospho 3-hexuloisomerase C7M26_02444 ENOG4105C8Q Methyl-accepting chemotaxis C7M26_02447 ENOG4105CS2 ec 3.2.1.21 C7M26_02449 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein C7M26_02450 ENOG4105E5Q amino acid AbC transporter C7M26_02451 ENOG4105CKI cobalamin synthesis protein C7M26_02452 ENOG4105S7A ErfK ybiS ycfS ynhG family protein C7M26_02456 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) C7M26_02457 ENOG4108IFG nitrite reductase, (NAD(P)H) C7M26_02458 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit C7M26_02459 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C7M26_02461 ENOG4105U6C Alpha beta hydrolase fold protein C7M26_02462 ENOG4108PJD permease C7M26_02464 ENOG4107YHD transcriptional regulator C7M26_02465 ENOG4105CK7 Sodium proline symporter C7M26_02466 ENOG4105C26 Dehydrogenase C7M26_02468 ENOG410756H nucleotidyltransferase C7M26_02469 ENOG4105I82 acetyl xylan esterase C7M26_02470 ENOG4105C5Q Transcriptional regulator C7M26_02471 ENOG41089UC methyltransferase, type 11 C7M26_02472 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) C7M26_02474 ENOG4105I1F Resistance protein C7M26_02475 ENOG4107RA1 nh(3)-dependent nad( ) synthetase C7M26_02476 ENOG4105EIG urea carboxylase-associated protein 1 C7M26_02483 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C7M26_02489 ENOG4107SQ8 Glycine betaine C7M26_02490 ENOG4108IJ7 Glycine betaine C7M26_02491 ENOG4108A65 Transcriptional regulator C7M26_02492 ENOG4107XZQ multidrug resistance protein C7M26_02493 ENOG41079KZ Major Facilitator Superfamily C7M26_02495 ENOG4108TTB tellurium resistance protein C7M26_02496 ENOG4107TS3 membrane protein, TerC C7M26_02497 ENOG4106FN3 tellurium resistance protein C7M26_02498 ENOG4106FN3 tellurium resistance protein C7M26_02499 ENOG4108N0M stress protein C7M26_02500 ENOG4105DEN Luciferase family C7M26_02502 ENOG4105DIK (ABC) transporter C7M26_02503 ENOG4105DSE periplasmic solute binding protein C7M26_02505 ENOG4105H9W Short-chain dehydrogenase reductase Sdr C7M26_02511 ENOG4107SET aldo keto reductase C7M26_02512 ENOG4108SDH ABC, transporter C7M26_02513 ENOG4108IUW ABC transporter C7M26_02514 ENOG4107Y7X LytTR C7M26_02515 ENOG4107Y7X LytTR C7M26_02517 ENOG41060AI SEC-C motif C7M26_02519 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold C7M26_02520 ENOG4107RB3 L-asparaginase C7M26_02521 ENOG4105J7D transcriptional regulator C7M26_02522 ENOG4105C0R drug resistance transporter emrb qaca subfamily C7M26_02523 ENOG4107EPV Aminotransferase class V C7M26_02524 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) C7M26_02525 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) C7M26_02526 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) C7M26_02527 ENOG4105DGI Alkaline phosphatase C7M26_02528 ENOG4105MUA Resistance protein C7M26_02534 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C7M26_02535 ENOG4106UX7 integral membrane protein C7M26_02538 ENOG4105CTX dehydratase C7M26_02539 ENOG41073TP transcriptional regulator C7M26_02540 ENOG4105EQX glucarate dehydratase C7M26_02541 ENOG4105DJB Major Facilitator Superfamily C7M26_02542 ENOG4105C26 Dehydrogenase C7M26_02543 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase C7M26_02546 ENOG4105CSV Glutaminase C7M26_02548 ENOG4108J5H Homocysteine s-methyltransferase C7M26_02549 ENOG4108IQI permease C7M26_02550 ENOG4105CM2 brancheD-chain amino acid aminotransferase C7M26_02553 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) C7M26_02554 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane C7M26_02556 ENOG4105C72 UPF0176 protein C7M26_02561 ENOG4107ZTW SNARE associated Golgi C7M26_02562 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase C7M26_02563 ENOG4108WC5 Alpha Beta Hydrolase Fold protein C7M26_02565 ENOG4108TCS Glutamyl endopeptidase C7M26_02566 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR C7M26_02567 ENOG4106AXJ AraC family transcriptional regulator C7M26_02568 ENOG410631K Membrane C7M26_02571 ENOG4105DCM major facilitator superfamily C7M26_02572 ENOG410645S MarR family Transcriptional regulator C7M26_02574 ENOG4105CXY transporter C7M26_02575 ENOG4107VXM glycerophosphoryl diester phosphodiesterase C7M26_02576 ENOG4107QTZ amino acid C7M26_02578 ENOG4107E6A Cytochrome p-450 C7M26_02579 ENOG4108HWY Beta-lactamase C7M26_02581 ENOG4106DDH Sporulation-specific SASP protein C7M26_02583 ENOG4106K80 C7M26_02585 ENOG4105G0J serine threonine protein kinase C7M26_02593 ENOG4108WUZ (ABC) transporter C7M26_02594 ENOG41066N6 Abortive infection protein C7M26_02595 ENOG4107ZBH radical SAM domain protein C7M26_02597 ENOG4108RWP Major Facilitator Superfamily protein C7M26_02598 ENOG4105WAB arsR family transcriptional regulator C7M26_02599 ENOG4105GPN Uncharacterized conserved protein (DUF2294) C7M26_02603 ENOG4108TWJ NADH dehydrogenase subunit 5 C7M26_02604 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C7M26_02606 ENOG4105D03 DNA-3-methyladenine glycosylase II C7M26_02607 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) C7M26_02608 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) C7M26_02609 ENOG4107U5W ybbr family C7M26_02610 ENOG4105C8B TIGR00159 family C7M26_02612 ENOG4105EMN RNA polymerase sigma factor C7M26_02618 ENOG4105EWC Purine nucleoside phosphorylase C7M26_02620 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate C7M26_02624 ENOG4105D17 glycoside hydrolase, family 3 domain protein C7M26_02625 ENOG4105EHZ conserved protein UCP016719 C7M26_02626 ENOG410874W AraC family transcriptional regulator C7M26_02630 ENOG4108SA1 esterase C7M26_02633 ENOG4105CHH sulfate transporter C7M26_02646 ENOG4108NMV polysaccharide deacetylase C7M26_02649 ENOG4105D1F ATP-binding protein C7M26_02652 ENOG4108I0C methyltransferase C7M26_02653 ENOG4108UJD 30S ribosomal protein S9 C7M26_02654 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) C7M26_02655 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) C7M26_02656 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) C7M26_02657 ENOG4108JJB ABC transporter C7M26_02658 ENOG4108JJB ABC transporter C7M26_02659 ENOG4108ZT0 50S ribosomal protein l17 C7M26_02660 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C7M26_02661 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) C7M26_02662 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits C7M26_02663 ENOG41067V7 50S ribosomal protein L36 C7M26_02665 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) C7M26_02667 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) C7M26_02668 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) C7M26_02670 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) C7M26_02671 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) C7M26_02672 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) C7M26_02673 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) C7M26_02675 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits C7M26_02677 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) C7M26_02678 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal C7M26_02680 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) C7M26_02681 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) C7M26_02684 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity C7M26_02686 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) C7M26_02687 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) C7M26_02688 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) C7M26_02689 ENOG4107SKW Inherit from COG: Alpha beta hydrolase C7M26_02690 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) C7M26_02691 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) C7M26_02692 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) C7M26_02693 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) C7M26_02694 ENOG4105XPM ribosomal protein C7M26_02695 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C7M26_02696 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C7M26_02697 ENOG4107Y49 methyltransferase C7M26_02699 ENOG4108VZM 50s ribosomal protein L10 C7M26_02702 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) C7M26_02705 ENOG4105M0M Tetracycline resistance protein C7M26_02706 ENOG4105C2N RNA methyltransferase TrmH family group 3 C7M26_02707 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) C7M26_02708 ENOG4105C8N cysteinyl-tRNA synthetase C7M26_02709 ENOG4105D7W serine acetyltransferase C7M26_02710 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) C7M26_02711 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) C7M26_02712 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) C7M26_02713 ENOG4105CTP PilT protein domain protein C7M26_02714 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) C7M26_02715 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) C7M26_02717 ENOG41066A3 ATP guanido phosphotransferase C7M26_02718 ENOG4108Z0C Uvrb UvrC protein C7M26_02735 ENOG4105CRK lysyL-tRNA synthetase C7M26_02736 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) C7M26_02738 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase C7M26_02739 ENOG4105KRF dihydroneopterin aldolase C7M26_02740 ENOG4105EEI dihydropteroate synthase C7M26_02741 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 C7M26_02742 ENOG4105DDQ anthranilate synthase C7M26_02743 ENOG4105CRQ synthase (Component I) C7M26_02744 ENOG4105C6T cysteine synthase C7M26_02745 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase C7M26_02746 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) C7M26_02748 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C7M26_02749 ENOG4108UGV hypoxanthine phosphoribosyltransferase C7M26_02750 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) C7M26_02756 ENOG41060GV RNA binding s1 domain protein C7M26_02759 ENOG4105VYY sporulation protein yabp C7M26_02760 ENOG41082I2 s4 domain protein C7M26_02761 ENOG4108IY2 MazG family C7M26_02763 ENOG4108M14 stage v sporulation protein t C7M26_02764 ENOG4108JA2 transcriptioN-repair coupling factor C7M26_02766 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) C7M26_02767 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) C7M26_02768 ENOG4105C5T Phosphoribosyl pyrophosphate synthase C7M26_02769 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) C7M26_02770 ENOG4105K4W Could be involved in septation (By similarity) C7M26_02771 ENOG4105KME endoribonuclease L-psp C7M26_02772 ENOG4105DFT pur operon repressor C7M26_02773 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) C7M26_02774 ENOG4105W42 Veg protein C7M26_02775 ENOG4105XFA sporulation peptidase YabG C7M26_02776 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) C7M26_02778 ENOG41069ER domain protein C7M26_02779 ENOG4105F8V Hydrolase, tatD family C7M26_02780 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) C7M26_02781 ENOG4105KRN Transcriptional regulator, abrb family C7M26_02782 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) C7M26_02783 ENOG4105VC4 domain protein C7M26_02784 ENOG41060K3 Methyltransferase C7M26_02785 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) C7M26_02786 ENOG4105MA4 psp1 domain protein C7M26_02787 ENOG4105FA2 dna polymerase iii C7M26_02788 ENOG4105XVJ Protein of unknown function (DUF327) C7M26_02789 ENOG4105X0R protein from nitrogen regulatory protein P-II C7M26_02790 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) C7M26_02791 ENOG4105CXN decarboxylase C7M26_02792 ENOG4105CDW Resistance protein C7M26_02800 ENOG41067KS pro-sigma K processing C7M26_02802 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) C7M26_02803 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) C7M26_02804 ENOG4105C6E dna polymerase iii C7M26_02805 ENOG4108Z6B deaminase C7M26_02806 ENOG4105GTG Isochorismatase C7M26_02807 ENOG4105VRS hydrolase family 18 C7M26_02809 ENOG4105ZMH deoxynucleoside kinase C7M26_02811 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) C7M26_02812 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) C7M26_02813 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) C7M26_02815 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C7M26_02822 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C7M26_02823 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C7M26_02826 ENOG410848D S4 domain protein YaaA C7M26_02827 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) C7M26_02828 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) C7M26_02829 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) C7M26_02832 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) C7M26_02833 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) C7M26_02834 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) C7M26_02837 ENOG4107QJE Chromosome Partitioning Protein C7M26_02838 ENOG4105FA0 parb-like partition protein C7M26_02839 ENOG4108ZDA Sporulation protein YyaC C7M26_02841 ENOG4105VDK protein, conserved in bacteria C7M26_02842 ENOG4108J2R molybdopterin oxidoreductase C7M26_02843 ENOG4105C3G gtp-binding protein C7M26_02844 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) C7M26_02845 ENOG4108UUM single-stranded DNA-binding protein C7M26_02846 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) C7M26_02847 ENOG4105CGK Exodeoxyribonuclease III C7M26_02849 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase C7M26_02850 ENOG4108UW5 maltose o-acetyltransferase C7M26_02852 ENOG4107FCW Abortive infection protein C7M26_02853 ENOG4105C7Z Conserved Protein C7M26_02855 ENOG4105N14 lysine exporter protein LysE YggA C7M26_02856 ENOG4105C7Z Conserved Protein C7M26_02857 ENOG4108IPJ Membrane C7M26_02861 ENOG4108J8C transporter major facilitator family protein C7M26_02862 ENOG4105NAE bifunctional deaminase-reductase domain protein C7M26_02863 ENOG4105UNS Pfam:DUF419 C7M26_02864 ENOG4108U7W acetyltransferase C7M26_02866 ENOG41082BV acetyltransferase C7M26_02867 ENOG4108U05 Transcriptional regulator C7M26_02869 ENOG41081I9 integral membrane protein C7M26_02870 ENOG41082BV acetyltransferase C7M26_02871 ENOG4107RSM transcriptional regulator C7M26_02872 ENOG4105D94 Major Facilitator Superfamily C7M26_02873 ENOG4105DDN Pentapeptide repeat-containing protein C7M26_02874 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein C7M26_02876 ENOG41090E6 transcriptional regulator MERR family C7M26_02880 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase C7M26_02881 ENOG4105KVH Transcriptional regulator C7M26_02884 ENOG4108XMW Membrane C7M26_02885 ENOG4105BZR domain protein C7M26_02886 ENOG4105K9Q Binds to the 23S rRNA (By similarity) C7M26_02887 ENOG4105EDW glycosyl transferase, family 39 C7M26_02888 ENOG4105DJ2 Major Facilitator Superfamily C7M26_02892 ENOG4105CDU Replicative dna helicase C7M26_02893 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase C7M26_02894 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis C7M26_02899 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C7M26_02900 ENOG4105BZU Histidine kinase C7M26_02903 ENOG4105Q2H domain protein C7M26_02904 ENOG4105C0H protease C7M26_02908 ENOG4105BZU Histidine kinase C7M26_02909 ENOG4108JUB Transcriptional regulator C7M26_02910 ENOG4105C8Y Acetylornithine aminotransferase C7M26_02911 ENOG4108IQI permease C7M26_02912 ENOG41066UZ arginase EC 3.5.3.1 C7M26_02914 ENOG410780I phosphoprotein phosphatase activity C7M26_02915 ENOG4105WQG acetyltransferase C7M26_02916 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) C7M26_02920 ENOG4105E2A Dehydrogenase C7M26_02923 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) C7M26_02925 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 C7M26_02926 ENOG4108Z15 abc transporter atp-binding protein C7M26_02927 ENOG4106KKU C7M26_02928 ENOG4108S3Y transcriptional regulator C7M26_02929 ENOG4105C5Y PTS System C7M26_02931 ENOG4105CS2 ec 3.2.1.21 C7M26_02932 ENOG4108JU3 Alkyl hydroperoxide reductase C7M26_02933 ENOG4105D3R alkyl hydroperoxide reductase C7M26_02934 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) C7M26_02935 ENOG4105C6Z Gluconate C7M26_02936 ENOG4105CMG Carbohydrate kinase C7M26_02937 ENOG4105G3Z GntR family transcriptional regulator C7M26_02938 ENOG4105BZW Glycerate kinase C7M26_02940 ENOG41067MG lrgb family C7M26_02942 ENOG41061AU MarR family Transcriptional regulator C7M26_02943 ENOG4107JEE Short-chain dehydrogenase reductase Sdr C7M26_02944 ENOG4105J7D transcriptional regulator C7M26_02947 ENOG41085PJ rdd domain containing protein C7M26_02949 ENOG4108ITS PQQ enzyme repeat C7M26_02951 ENOG4105C26 Dehydrogenase C7M26_02952 ENOG4105ST3 Transcriptional regulator C7M26_02953 ENOG41061TZ Short-chain dehydrogenase reductase Sdr C7M26_02955 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) C7M26_02956 ENOG4107QNK )-transporter C7M26_02959 ENOG4105CPC Aldo Keto reductase C7M26_02961 ENOG4105C26 Dehydrogenase C7M26_02962 ENOG4105DH8 myo-inositol catabolism C7M26_02963 ENOG4105D7K pfkb domain protein C7M26_02964 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) C7M26_02965 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) C7M26_02967 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) C7M26_02968 ENOG4105F0H myo-inositol catabolism protein C7M26_02969 ENOG4107TRN Xylose isomerase domain protein TIM barrel C7M26_02970 ENOG4105D2N Aldolase C7M26_02976 ENOG4108V5C ABC transporter C7M26_02982 ENOG410667J hydrolase C7M26_02983 ENOG4107QHE Choloylglycine hydrolase C7M26_02986 ENOG4105EAB amino acid AbC transporter C7M26_02987 ENOG4108HW4 amino acid AbC transporter C7M26_02990 ENOG4108PGP mmge prpd family protein C7M26_02991 ENOG4105ENY Ethanolamine utilization protein eutH C7M26_02992 ENOG4108TM9 integral membrane protein C7M26_02993 ENOG4107RHR regulatoR C7M26_02995 ENOG4105D9N nucleoside C7M26_02996 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) C7M26_02998 ENOG4107W25 arginase agmatinase formiminoglutamase C7M26_02999 ENOG4105CI2 imidazolone-5-propionate hydrolase C7M26_03000 ENOG4105CGP Urocanate hydratase C7M26_03001 ENOG4105C84 Histidine ammonia-lyase C7M26_03003 ENOG4106Z5D Glycoside Hydrolase Family 43 C7M26_03006 ENOG4107EV6 Inherit from COG: YD repeat protein C7M26_03008 ENOG4105C5Y PTS System C7M26_03009 ENOG4105CS2 ec 3.2.1.21 C7M26_03010 ENOG4107YZX Universal stress protein C7M26_03012 ENOG4105CNA YD repeat protein C7M26_03022 ENOG4107TDE lipolytic protein G-D-S-L family C7M26_03023 ENOG4105C1J atp-dependent rna helicase C7M26_03024 ENOG4105DEU major facilitator superfamily C7M26_03026 ENOG4105CID antiterminator C7M26_03027 ENOG4108RZ2 Glycoside hydrolase family 16 C7M26_03028 ENOG4105D4T Citrate transporter C7M26_03029 ENOG4105CH6 catalase C7M26_03033 ENOG4105DHI Methyltransferase C7M26_03034 ENOG4105CY2 Citrate transporter C7M26_03035 ENOG4105CY2 Citrate transporter C7M26_03036 ENOG4105D6N CoA-transferase, subunit a C7M26_03037 ENOG4108IIH CoA-transferase subunit B C7M26_03038 ENOG4105DTD Dehydrogenase C7M26_03044 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) C7M26_03045 ENOG4105WH1 Two component transcriptional regulator luxr family C7M26_03046 ENOG4105BZU Histidine kinase C7M26_03048 ENOG4105CMR udp-glucose 4-epimerase C7M26_03050 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) C7M26_03054 ENOG4107BJW polysaccharide deacetylase C7M26_03057 ENOG4105D2K citrate carrier protein C7M26_03058 ENOG4105C4M (Ubiquinol oxidase) subunit I C7M26_03059 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C7M26_03060 ENOG4108JJ9 ABC, transporter C7M26_03061 ENOG4108JJ8 (ABC) transporter C7M26_03062 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) C7M26_03063 ENOG4105ETS cytosine purines uracil thiamine allantoin C7M26_03067 ENOG41069JR C7M26_03068 ENOG4105DA5 (ABC) transporter C7M26_03071 ENOG4105CH6 catalase C7M26_03072 ENOG4108VX5 3-methyladenine DNA glycosylase C7M26_03074 ENOG4105EMD TRANSCRIPTIONal C7M26_03075 ENOG4105VZJ PTS System C7M26_03076 ENOG4105CK1 PTS System C7M26_03077 ENOG4105VCP PTS System C7M26_03078 ENOG4105F8D glycoside hydrolase family 4 C7M26_03079 ENOG4105CM2 brancheD-chain amino acid aminotransferase C7M26_03080 ENOG4108VHC Short-chain dehydrogenase reductase Sdr C7M26_03081 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD C7M26_03083 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein C7M26_03084 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) C7M26_03085 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase C7M26_03090 ENOG4105IIU Aminopeptidase C7M26_03091 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C7M26_03092 ENOG4105GVJ transcriptional regulator C7M26_03094 ENOG4105X1N Glycosyl transferase family 8 C7M26_03097 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin C7M26_03098 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin C7M26_03099 ENOG4105CK1 PTS System C7M26_03100 ENOG4108YV3 Protein of unknown function (DUF2711) C7M26_03101 ENOG4108YV3 Protein of unknown function (DUF2711) C7M26_03104 ENOG4105DR4 Methyltransferase C7M26_03106 ENOG4105D8G Major Facilitator superfamily C7M26_03107 ENOG41067MG lrgb family C7M26_03108 ENOG4105VAW lrga family C7M26_03109 ENOG4105CMU LysR family (Transcriptional regulator C7M26_03111 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) C7M26_03112 ENOG4107SJW iron permease, FTR1 C7M26_03113 ENOG410650H (LipO)protein C7M26_03114 ENOG4105DBE peroxidase C7M26_03115 ENOG4107ZXU DSBA oxidoreductase C7M26_03120 ENOG4105WH5 Teichoic acid glycosylation protein C7M26_03121 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) C7M26_03123 ENOG4107BMA Transglycosylase associated protein C7M26_03124 ENOG4105E2S oxidase) subunit II C7M26_03125 ENOG4105BZ9 Cytochrome C oxidase, subunit I C7M26_03126 ENOG4105CCU oxidase (Subunit III) C7M26_03127 ENOG41060D1 Quinol oxidase C7M26_03130 ENOG4108DBC nitroreductase C7M26_03131 ENOG4105DEN Luciferase family C7M26_03132 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin C7M26_03135 ENOG4108QTI )-transporter C7M26_03136 ENOG4105C5Y PTS System C7M26_03139 ENOG4105DWF phosphomethylpyrimidine kinase C7M26_03140 ENOG4108RJ9 Glycosyl transferase, family 2 C7M26_03141 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) C7M26_03142 ENOG4105C26 Dehydrogenase C7M26_03149 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C7M26_03150 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD C7M26_03152 ENOG4107TY6 Acylneuraminate cytidylyltransferase C7M26_03153 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG C7M26_03154 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) C7M26_03155 ENOG4105C1B dTDP-glucose 4-6-dehydratase C7M26_03156 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase C7M26_03157 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase C7M26_03159 ENOG4105D82 Glutamate dehydrogenase C7M26_03160 ENOG4105C26 Dehydrogenase C7M26_03163 ENOG4105FCW Major Facilitator superfamily C7M26_03164 ENOG41061WN bacilysin biosynthesis protein C7M26_03165 ENOG4106CHD Bacilysin biosynthesis protein bacB C7M26_03166 ENOG4105CHR reductase C7M26_03167 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase C7M26_03169 ENOG4105CHM Aminotransferase C7M26_03172 ENOG4108IJ2 phosphate acetyltransferase C7M26_03173 ENOG4105DUM transcriptional regulator, lysR family C7M26_03174 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) C7M26_03175 ENOG4108RNG Permease of the drug metabolite transporter C7M26_03176 ENOG4108VCI transcription factor, rsfa family C7M26_03178 ENOG4105DCI Phosphohydrolase C7M26_03180 ENOG41062ES Transcriptional regulator C7M26_03181 ENOG4105C57 major facilitator superfamily C7M26_03183 ENOG4105C22 threonyL-tRNA synthetase C7M26_03184 ENOG41067TZ transcriptional regulator, MarR family C7M26_03185 ENOG41069HH 4-oxalocrotonate tautomerase C7M26_03186 ENOG4108Z4T Peptidase M50 C7M26_03187 ENOG4108XFG YwhD family C7M26_03188 ENOG4105BZ4 penicillin-binding protein C7M26_03189 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) C7M26_03190 ENOG4105CYW agmatinase C7M26_03192 ENOG4107JM4 Tetratricopeptide repeat C7M26_03201 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E C7M26_03203 ENOG410684U Domain of unknown function (DUF1934) C7M26_03204 ENOG4105C75 arginyL-tRNA synthetase C7M26_03206 ENOG4107V6Q Cyclic nucleotide-binding domain C7M26_03210 ENOG4108IUE nitrate reductase beta subunit C7M26_03211 ENOG4105R3A Nitrate reductase C7M26_03213 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C7M26_03214 ENOG4105BZ1 (ABC) transporter C7M26_03215 ENOG4105NAE bifunctional deaminase-reductase domain protein C7M26_03217 ENOG4105E5J UV damage endonuclease C7M26_03219 ENOG4105DF6 Fe-S oxidoreductase C7M26_03220 ENOG4105C1G acyl-Coa dehydrogenase C7M26_03222 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) C7M26_03224 ENOG410812K response regulator receiver protein C7M26_03225 ENOG4105D2N Aldolase C7M26_03226 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway C7M26_03227 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C7M26_03228 ENOG4105CBT Fructose-1,6-bisphosphatase C7M26_03229 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) C7M26_03231 ENOG4107104 thymidine kinase C7M26_03232 ENOG4105C6K Malic enzyme C7M26_03233 ENOG4107TT2 Auxin Efflux Carrier C7M26_03235 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase C7M26_03236 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) C7M26_03237 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) C7M26_03240 ENOG4108ZXQ stage ii sporulation protein r C7M26_03242 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C7M26_03243 ENOG410815N Probably functions as a manganese efflux pump (By similarity) C7M26_03244 ENOG4107WAU Protein tyrosine phosphatase C7M26_03245 ENOG4108YZG isomerase C7M26_03246 ENOG4108UIC UPF0340 protein C7M26_03247 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) C7M26_03248 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) C7M26_03250 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) C7M26_03254 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) C7M26_03255 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) C7M26_03256 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) C7M26_03257 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) C7M26_03259 ENOG4106778 Protein of unknown function (DUF1146) C7M26_03261 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C7M26_03262 ENOG4105JFG SpoIID LytB domain protein C7M26_03264 ENOG4108TF4 von Willebrand factor, type A C7M26_03266 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) C7M26_03272 ENOG4108YZ9 Urea amidohydrolase subunit gamma C7M26_03273 ENOG4105KI2 Urea amidohydrolase subunit beta C7M26_03274 ENOG4105CQM Urea amidohydrolase subunit alpha C7M26_03275 ENOG4105CQM Urea amidohydrolase subunit alpha C7M26_03276 ENOG4108Z40 Transcriptional regulator C7M26_03277 ENOG4108RYK Nad-dependent epimerase dehydratase C7M26_03278 ENOG4106BRK C7M26_03279 ENOG4107TXC Transcriptional regulator C7M26_03280 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C7M26_03283 ENOG4107TCE N-acetyltransferase C7M26_03284 ENOG4105FRN stage II sporulation protein C7M26_03286 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase C7M26_03288 ENOG4105BZU Histidine kinase C7M26_03289 ENOG4107P26 C7M26_03290 ENOG4105D3W isochorismatase C7M26_03291 ENOG41080V3 Major Facilitator superfamily C7M26_03292 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease C7M26_03293 ENOG4108M26 parallel beta-helix repeat protein C7M26_03294 ENOG4105CZM Major Facilitator C7M26_03295 ENOG4107MII Sugar-specific transcriptional regulator TrmB C7M26_03296 ENOG4105MT0 Sporulation transcriptional regulator spoiiid C7M26_03297 ENOG4105DFF Rod shape-determining protein mreb C7M26_03299 ENOG4105CGA flagellar basal-body rod protein FlgG C7M26_03301 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) C7M26_03302 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) C7M26_03307 ENOG4105Z8H single-stranded DNA-binding protein C7M26_03308 ENOG4105E98 transcriptional regulator DeoR family C7M26_03309 ENOG410667J hydrolase C7M26_03310 ENOG4105C0D helicase C7M26_03311 ENOG4105KBK Zinc finger, swim domain protein C7M26_03313 ENOG4105HTX biosynthesis protein C7M26_03314 ENOG4107YJ4 chain length determinant protein C7M26_03315 ENOG4108RB3 Capsular polysaccharide biosynthesis protein C7M26_03316 ENOG4105C6Y Udp-glucose 6-dehydrogenase C7M26_03317 ENOG4108XI2 Domain of unknown function (DUF1963) C7M26_03322 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) C7M26_03323 ENOG4107V2S Transcriptional regulator C7M26_03324 ENOG4108WS4 fmn reductase C7M26_03326 ENOG4105FGV Chromate C7M26_03327 ENOG4105CAH Chromate C7M26_03329 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C7M26_03331 ENOG4107XC4 flavin reductase domain protein, FMN-binding C7M26_03334 ENOG4106UIA C7M26_03337 ENOG4107RSM transcriptional regulator C7M26_03339 ENOG4107FQX Alpha-acetolactate decarboxylase C7M26_03340 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein C7M26_03343 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator C7M26_03344 ENOG4105CNN ABC, transporter C7M26_03345 ENOG4105C2J ABC transporter C7M26_03346 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) C7M26_03347 ENOG4108RVA ribokinase C7M26_03348 ENOG4105ETE Transcriptional regulator (LacI family C7M26_03349 ENOG4105N98 Capsule biosynthesis protein capB C7M26_03351 ENOG4105PNM synthesis protein C7M26_03353 ENOG4105K4H Nlp p60 protein C7M26_03354 ENOG4105J7I hydrolase C7M26_03355 ENOG4108KGH TRANSCRIPTIONal C7M26_03356 ENOG4105C54 Major Facilitator superfamily C7M26_03357 ENOG4108NHD germination protein C7M26_03360 ENOG4105DG6 mannose-6-phosphate isomerase C7M26_03362 ENOG410651K Teichoic acid biosynthesis protein C C7M26_03363 ENOG4107RZX Teichoic acid biosynthesis protein C7M26_03365 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase C7M26_03366 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) C7M26_03367 ENOG4107SJB teichoic acid biosynthesis C7M26_03369 ENOG4105EY8 ABC transporter C7M26_03370 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C7M26_03372 ENOG41088M2 Glycosyl transferase family 2 C7M26_03373 ENOG4107VDP teichoic acid biosynthesis C7M26_03374 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C7M26_03375 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase C7M26_03378 ENOG4105JFG SpoIID LytB domain protein C7M26_03379 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C7M26_03380 ENOG4105D3Q Sugar transferase C7M26_03381 ENOG4105PSV Polysaccharide Biosynthesis Protein C7M26_03382 ENOG4107RA4 Glycosyl transferase (Group 1 C7M26_03383 ENOG4105C6Y Udp-glucose 6-dehydrogenase C7M26_03384 ENOG4105QZI O-Antigen Polymerase C7M26_03387 ENOG4107EF8 Glycosyl transferase (Group 1 C7M26_03388 ENOG4105ESV Glycosyl transferase, family 4 C7M26_03389 ENOG4108KGH TRANSCRIPTIONal C7M26_03390 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein C7M26_03391 ENOG4105BZU Histidine kinase C7M26_03392 ENOG4105WH1 Two component transcriptional regulator luxr family C7M26_03396 ENOG41081UC Inherit from COG: Competence protein C7M26_03397 ENOG4105RU3 C7M26_03400 ENOG4105E1Q flagellar hook-associated protein C7M26_03401 ENOG4105DTJ flagellar hook-associated protein C7M26_03402 ENOG4105MKD C7M26_03403 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) C7M26_03404 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) C7M26_03405 ENOG4105I03 Flagellin C7M26_03406 ENOG41083S7 flagellar protein FlaG C7M26_03407 ENOG4107RT6 flagellar hook-associated C7M26_03408 ENOG4105MQ3 flagellar protein FliS C7M26_03411 ENOG4105MS2 ribosomal subunit Interface protein C7M26_03413 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) C7M26_03416 ENOG4105CAK Cell division ATP-binding protein ftsE C7M26_03417 ENOG4105CRP Part of the ABC transporter FtsEX involved in C7M26_03418 ENOG4105CN1 protease C7M26_03422 ENOG4105MKU Transcriptional regulator C7M26_03425 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) C7M26_03426 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) C7M26_03430 ENOG4108PY7 C7M26_03431 ENOG41067S9 phage shock protein C, PspC C7M26_03432 ENOG41086DT Membrane protein of unknown function C7M26_03435 ENOG410625E C7M26_03436 ENOG4106A3M Cytochrome p-450 C7M26_03438 ENOG41088CQ domain protein C7M26_03440 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) C7M26_03441 ENOG4105CE4 GlcNAc 6-P deacetylase C7M26_03442 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) C7M26_03443 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) C7M26_03444 ENOG4105HKU nucleoside recognition domain-containing protein C7M26_03445 ENOG4107XGZ Hydrolase C7M26_03446 ENOG4108S4C acetyltransferase C7M26_03447 ENOG4108E16 pectate lyase C7M26_03449 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) C7M26_03450 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) C7M26_03451 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) C7M26_03452 ENOG4105ECC imidazole-glycerol-phosphate dehydratase C7M26_03453 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) C7M26_03454 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase C7M26_03455 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) C7M26_03456 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase C7M26_03458 ENOG4106FGC C7M26_03460 ENOG4105BZ1 (ABC) transporter C7M26_03463 ENOG4105C3M thioredoxin reductase C7M26_03464 ENOG4108Z4K mutator MutT protein C7M26_03465 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) C7M26_03466 ENOG4105CHW UPF0052 protein C7M26_03467 ENOG4105CIE May be required for sporulation (By similarity) C7M26_03468 ENOG4105KRI phosphocarrier protein (HPr C7M26_03469 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase C7M26_03470 ENOG4107A6P C7M26_03472 ENOG4105EWM Histidine kinase C7M26_03473 ENOG4105C19 ABC transporter C7M26_03475 ENOG4105C5I Dehydrogenase C7M26_03476 ENOG4108V2W Carbonate dehydratase C7M26_03477 ENOG4105CHH sulfate transporter C7M26_03478 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain C7M26_03479 ENOG4108URH decarboxylase C7M26_03480 ENOG4105FKQ transcriptional regulator C7M26_03481 ENOG4108IUK alpha amylase, catalytic C7M26_03482 ENOG4107FKK extracellular solute-binding protein family 1 C7M26_03483 ENOG4105D56 permease protein C7M26_03484 ENOG4105EG2 ABC transporter, permease C7M26_03487 ENOG4105CG3 alpha amylase, catalytic region C7M26_03488 ENOG4107URF beta-phospho-glucomutase C7M26_03489 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C7M26_03491 ENOG4105IRW patatin-like phospholipase family protein C7M26_03492 ENOG4105DNP FAD linked oxidase domain protein C7M26_03497 ENOG4107QTZ amino acid C7M26_03498 ENOG4108HKT sucrose-6-phosphate hydrolase C7M26_03499 ENOG4105EDQ levansucrase EC 2.4.1.10 C7M26_03500 ENOG4105FQP Beta-lactamase C7M26_03502 ENOG4105NI3 Protein of unknown function (DUF3237) C7M26_03503 ENOG4105PY6 Phenolic acid decarboxylase C7M26_03505 ENOG4105EBR Carboxylesterase C7M26_03507 ENOG4105HTX biosynthesis protein C7M26_03508 ENOG4108QV3 biosynthesis protein C7M26_03510 ENOG4108PQP glycosyl transferase group 1 C7M26_03511 ENOG4105K64 Glycosyl transferase, family 2 C7M26_03512 ENOG4108KMV Glycosyl transferase (Group 1 C7M26_03513 ENOG41068W6 Capsular polysaccharide biosynthesis protein C7M26_03514 ENOG4107QRS glycosyltransferase group 2 family protein C7M26_03516 ENOG4105K64 Glycosyl transferase, family 2 C7M26_03518 ENOG4105D3Q Sugar transferase C7M26_03519 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family C7M26_03520 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C7M26_03521 ENOG4108ZPC Polysaccharide pyruvyl transferase C7M26_03523 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C7M26_03524 ENOG4105DAA L-lactate C7M26_03525 ENOG4105JXH GntR family transcriptional regulator C7M26_03527 ENOG4107FKK extracellular solute-binding protein family 1 C7M26_03529 ENOG4105EG2 ABC transporter, permease C7M26_03532 ENOG4108MJI response regulator C7M26_03533 ENOG4107R6F Alpha Beta Hydrolase Fold protein C7M26_03534 ENOG4108M15 ABC transporter C7M26_03535 ENOG4105KCT ABC transporter C7M26_03536 ENOG4105BZU Histidine kinase C7M26_03538 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C7M26_03539 ENOG4107QR9 Iron-sulfur cluster binding protein C7M26_03540 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) C7M26_03541 ENOG4105VRS hydrolase family 18 C7M26_03543 ENOG4107RT3 EamA-like transporter family C7M26_03544 ENOG4105GZI Transcriptional regulator C7M26_03545 ENOG4105DEN Luciferase family C7M26_03546 ENOG4105CMD Transcriptional regulator, GntR family C7M26_03549 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C7M26_03550 ENOG4105BZA Phosphoglycerate kinase C7M26_03551 ENOG4105CP7 Triose-phosphate isomerase C7M26_03552 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) C7M26_03553 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) C7M26_03554 ENOG4108W0I acetyltransferase C7M26_03555 ENOG4105T65 Membrane-associated protein C7M26_03557 ENOG4108QCI YvbH-like oligomerisation region C7M26_03558 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein C7M26_03559 ENOG4107HG4 Transcriptional regulator C7M26_03560 ENOG4108IJ8 ABC transporter C7M26_03561 ENOG4105E90 ABC transporter C7M26_03562 ENOG4108HQR Glycine betaine C7M26_03563 ENOG4105R40 Glycine betaine carnitine choline C7M26_03564 ENOG41082BM Transcriptional regulator, arsr family C7M26_03567 ENOG4105H5S C7M26_03569 ENOG4107HG4 Transcriptional regulator C7M26_03570 ENOG4108IJ8 ABC transporter C7M26_03571 ENOG4105E90 ABC transporter C7M26_03572 ENOG4108HQR Glycine betaine C7M26_03573 ENOG4105R40 Glycine betaine carnitine choline C7M26_03574 ENOG4105C8Q Methyl-accepting chemotaxis C7M26_03575 ENOG4105KVH Transcriptional regulator C7M26_03581 ENOG4105XZU Preprotein translocase, subunit SecG C7M26_03583 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) C7M26_03584 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) C7M26_03586 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C7M26_03627 ENOG4108FKH Transglycosylase SLT domain C7M26_03631 ENOG41068G1 C7M26_03635 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase C7M26_03640 ENOG4105EWI Short-chain dehydrogenase reductase Sdr C7M26_03641 ENOG4105KBX Transcriptional regulator, TetR family C7M26_03642 ENOG4105KPY Small multidrug resistance protein C7M26_03643 ENOG4105RXJ C7M26_03644 ENOG4105ME7 Membrane C7M26_03645 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C7M26_03646 ENOG4105D9R oxidoreductase C7M26_03647 ENOG4105VPX protein, conserved in bacteria C7M26_03648 ENOG410681U heavy metal transport detoxification protein C7M26_03649 ENOG4105C59 p-type ATPase C7M26_03650 ENOG4105C59 p-type ATPase C7M26_03651 ENOG4107ZQN disulfide bond C7M26_03653 ENOG4105EN6 Membrane C7M26_03655 ENOG4105EEM helicase C7M26_03656 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C7M26_03657 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) C7M26_03658 ENOG4105EEQ Na H antiporter C7M26_03661 ENOG4105E0C molybdate abc transporter C7M26_03662 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein C7M26_03663 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family C7M26_03664 ENOG4107QZ2 Sulfatase C7M26_03665 ENOG4107K5X Membrane-bound metal-dependent hydrolase C7M26_03667 ENOG4105D5Q Arginine ornithine antiporter C7M26_03669 ENOG4105DQ5 transport system permease protein C7M26_03670 ENOG4105EHG Permease protein C7M26_03671 ENOG4105E0A ABC, transporter C7M26_03672 ENOG4108WMK Efflux transporter RND family MFP subunit C7M26_03673 ENOG4105C19 ABC transporter C7M26_03674 ENOG4107RBB ABC transporter, permease C7M26_03676 ENOG4105F0F Oxalate decarboxylase C7M26_03678 ENOG4106DF4 Sigma-70, region 4 C7M26_03680 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C7M26_03682 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein C7M26_03683 ENOG4105EWI Short-chain dehydrogenase reductase Sdr C7M26_03684 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) C7M26_03685 ENOG4105EHG Permease protein C7M26_03686 ENOG4105E0A ABC, transporter C7M26_03687 ENOG4108WBT adenosyltransferase C7M26_03690 ENOG41087YS Phage shock protein A C7M26_03693 ENOG4105ENE Histidine kinase C7M26_03694 ENOG4105WH1 Two component transcriptional regulator luxr family C7M26_03699 ENOG4105C9Q fumarate hydratase class II C7M26_03700 ENOG41067SE Tetr family transcriptional regulator C7M26_03701 ENOG4105F3H Histidine kinase C7M26_03703 ENOG4105C0H protease C7M26_03704 ENOG4105HUF DNA protection during starvation protein C7M26_03705 ENOG4105E1F short-chain dehydrogenase reductase C7M26_03708 ENOG4105E0A ABC, transporter C7M26_03710 ENOG4105EGI Transcriptional regulator C7M26_03712 ENOG4105MDS 4-oxalocrotonate tautomerase C7M26_03713 ENOG4105C0R drug resistance transporter emrb qaca subfamily C7M26_03714 ENOG41067TZ transcriptional regulator, MarR family C7M26_03720 ENOG4105CHU acetyl-coa acetyltransferase C7M26_03721 ENOG4105C1G acyl-Coa dehydrogenase C7M26_03722 ENOG41080E8 Transcriptional regulator, Spx MgsR family C7M26_03723 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) C7M26_03728 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C7M26_03729 ENOG4108UMI ABC transporter, permease C7M26_03730 ENOG4105D01 (LipO)protein C7M26_03732 ENOG4105C3K feS assembly ATPase SufC C7M26_03733 ENOG4105JRK feS assembly protein SufD C7M26_03734 ENOG4105C9B Cysteine desulfurase C7M26_03735 ENOG4108UNV SUF system FeS assembly protein, NifU family C7M26_03736 ENOG4105DIW FeS assembly protein SUFB C7M26_03737 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase C7M26_03740 ENOG4107VFR oxidoreductase C7M26_03741 ENOG4105PKS Excinuclease abc c subunit domain protein C7M26_03742 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine C7M26_03743 ENOG4105XN3 extracellular solute-binding protein family 1 C7M26_03744 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component C7M26_03745 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component C7M26_03746 ENOG4108KPW sugar kinase C7M26_03747 ENOG4105FDP GntR family transcriptional regulator C7M26_03748 ENOG4108IJ9 (ABC) transporter C7M26_03749 ENOG4108K8S endonuclease I C7M26_03751 ENOG4105C5R Aminotransferase C7M26_03753 ENOG4105XRQ Xanthine dehydrogenase accessory factor C7M26_03756 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding C7M26_03757 ENOG4107YV9 domain protein C7M26_03758 ENOG4105VT2 5-hydroxyisourate hydrolase C7M26_03759 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) C7M26_03762 ENOG4105G9B Transcriptional regulator C7M26_03763 ENOG4105CD3 dihydroorotase C7M26_03765 ENOG4105I3N Conserved Protein C7M26_03767 ENOG4107R8B 5'-nucleotidase C7M26_03768 ENOG4105KZD Domain of unknown function (DUF1805) C7M26_03769 ENOG4108YTE sporulation protein YunB C7M26_03770 ENOG4105FAA peptidase M23 C7M26_03771 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) C7M26_03772 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) C7M26_03773 ENOG4105MMD transcriptional regulator C7M26_03775 ENOG4105D4U had-superfamily hydrolase, subfamily iia C7M26_03776 ENOG4108W5N phosphatidylglycerophosphatase a C7M26_03778 ENOG4105D6E homoserine dehydrogenase C7M26_03779 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) C7M26_03780 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) C7M26_03781 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein C7M26_03782 ENOG41083MR nifu domain-containing protein C7M26_03785 ENOG4105ZKE UPF0349 protein C7M26_03788 ENOG4108YX9 iron--sulfur cluster insertion protein erpA C7M26_03789 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 C7M26_03793 ENOG4105CAY ferredoxin--nadp reductase C7M26_03794 ENOG4105CEP NADH dehydrogenase C7M26_03796 ENOG41069ER domain protein C7M26_03798 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) C7M26_03802 ENOG4105NIV Esterase C7M26_03803 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase C7M26_03804 ENOG4105E4F Isochorismate synthase C7M26_03805 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase C7M26_03806 ENOG4105WQI isochorismatase C7M26_03807 ENOG4105CEY Amp-dependent synthetase and ligase C7M26_03808 ENOG4105WQT MbtH domain protein C7M26_03810 ENOG4105DCF alanine dehydrogenase C7M26_03811 ENOG4108K8K Transcriptional regulator C7M26_03818 ENOG410904N short-chain dehydrogenase reductase C7M26_03822 ENOG4105C02 permease C7M26_03827 ENOG4105DAP Nicotinate phosphoribosyltransferase C7M26_03828 ENOG4105D58 Diguanylate phosphodiesterase C7M26_03833 ENOG4105BZU Histidine kinase C7M26_03835 ENOG4105KA0 thioesterase Superfamily protein C7M26_03836 ENOG4105KJM monovalent cation h antiporter subunit g C7M26_03838 ENOG4105SC1 monovalent cation H antiporter subunit E C7M26_03839 ENOG4108JPZ Monovalent cation H antiporter subunit D C7M26_03840 ENOG4108ZE9 Monovalent cation H antiporter subunit C C7M26_03841 ENOG4105HC0 Na H antiporter C7M26_03842 ENOG4105D65 subunit l C7M26_03846 ENOG4105UIB (ABC) transporter C7M26_03847 ENOG4108JQ9 ABC transporter C7M26_03848 ENOG4105DIH basic membrane C7M26_03849 ENOG4108MRH transcriptional regulatory protein C7M26_03852 ENOG4105KIR Thiol-disulfide oxidoreductase dcc C7M26_03853 ENOG4105BZ4 penicillin-binding protein C7M26_03857 ENOG4105Y38 Kinase-associated protein B C7M26_03858 ENOG4108HGU Histidine kinase C7M26_03859 ENOG4105C87 Aminotransferase class I and II C7M26_03861 ENOG4108MUZ hydrolase C7M26_03862 ENOG4108ZB6 transcriptional regulator AsnC family C7M26_03863 ENOG4105CHM Aminotransferase C7M26_03865 ENOG4105WG9 Conserved Protein C7M26_03866 ENOG4107QW4 alcohol dehydrogenase C7M26_03868 ENOG4107QYV phosphohexose isomerase C7M26_03871 ENOG4107PBV potassium channel C7M26_03872 ENOG4107PBV potassium channel C7M26_03875 ENOG4105C37 (CBS) domain C7M26_03877 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme C7M26_03880 ENOG4105C8Q Methyl-accepting chemotaxis C7M26_03881 ENOG4105C8Q Methyl-accepting chemotaxis C7M26_03882 ENOG4105C8Q Methyl-accepting chemotaxis C7M26_03883 ENOG4105C8Q Methyl-accepting chemotaxis C7M26_03885 ENOG4105E98 transcriptional regulator DeoR family C7M26_03886 ENOG4105DET Rhamnulokinase C7M26_03887 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) C7M26_03888 ENOG4105DKG l-rhamnose isomerase C7M26_03889 ENOG4105EE0 oxidoreductase C7M26_03891 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) C7M26_03895 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj C7M26_03896 ENOG4107I77 yiaA/B two helix domain C7M26_03897 ENOG4105CZN Potassium uptake protein C7M26_03900 ENOG4105TRT Transcriptional regulator C7M26_03902 ENOG4108JB8 alcohol dehydrogenase C7M26_03903 ENOG4108VNY MOSC domain protein C7M26_03904 ENOG4106DF1 C7M26_03906 ENOG4105DZ6 Band 7 protein C7M26_03907 ENOG4105VRR gCN5-related N-acetyltransferase C7M26_03908 ENOG4105N67 Proton-coupled thiamine transporter YuaJ C7M26_03934 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) C7M26_03936 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) C7M26_03939 ENOG4108KS4 Spore coat protein C7M26_03940 ENOG4107SBE Glycosyl transferase (Group 1 C7M26_03943 ENOG4107SBE Glycosyl transferase (Group 1 C7M26_03944 ENOG4108IAJ Nad-dependent epimerase dehydratase C7M26_03948 ENOG4105E4F Isochorismate synthase C7M26_03949 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) C7M26_03950 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) C7M26_03951 ENOG4108IPT Naphthoate synthase C7M26_03952 ENOG4105CEY Amp-dependent synthetase and ligase C7M26_03953 ENOG4105DTQ mandelate racemase muconate lactonizing C7M26_03954 ENOG4105DSE periplasmic solute binding protein C7M26_03955 ENOG4105DIK (ABC) transporter C7M26_03956 ENOG4105CC5 ABC transporter C7M26_03957 ENOG4105CC5 ABC transporter C7M26_03962 ENOG4108V2W Carbonate dehydratase C7M26_03963 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) C7M26_03966 ENOG4108RMU ferritin dps family protein C7M26_03969 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component C7M26_03971 ENOG4105D2X ABC transporter substrate-binding protein C7M26_03974 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase C7M26_03975 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP C7M26_03976 ENOG4105CAQ asparagine synthetase C7M26_03977 ENOG4105C85 amino acid C7M26_03978 ENOG4108Z0R Transferase C7M26_03979 ENOG4105E8V Alpha Beta Hydrolase Fold protein C7M26_03982 ENOG4105N5T Radical SAM Protein C7M26_03985 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family C7M26_03986 ENOG4105DVE abc transporter atp-binding protein C7M26_03989 ENOG4105C19 ABC transporter C7M26_03990 ENOG4107R34 abc transporter permease protein C7M26_03992 ENOG4105EWM Histidine kinase C7M26_03993 ENOG4105C19 ABC transporter C7M26_03995 ENOG4106UBQ C7M26_03996 ENOG410605W Major Facilitator C7M26_03997 ENOG4105BZU Histidine kinase C7M26_03999 ENOG4105C8T Leucyl-tRNA synthetase C7M26_04000 ENOG41085GJ domain protein C7M26_04006 ENOG4105NTD Inherit from COG: Hydrolase C7M26_04008 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C7M26_04009 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) C7M26_04011 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) C7M26_04012 ENOG4106A3M Cytochrome p-450 C7M26_04014 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component C7M26_04016 ENOG41075H3 AraC family transcriptional regulator C7M26_04018 ENOG4105F5H Glycosyl Hydrolase Family 88 C7M26_04020 ENOG4105DDC Oxidoreductase domain protein C7M26_04021 ENOG4105MU9 integral membrane protein C7M26_04023 ENOG4105C94 Transporter C7M26_04024 ENOG4105CBX hi0933 family C7M26_04027 ENOG4105YW5 deoR family transcriptional regulator C7M26_04030 ENOG4105C7N Xanthine uracil vitamin C permease C7M26_04031 ENOG4107QSE Dipeptidase C7M26_04032 ENOG4105C6T cysteine synthase C7M26_04033 ENOG4107F58 2'-5' rna ligase C7M26_04036 ENOG4108IUM Glycogen debranching enzyme C7M26_04037 ENOG4108V15 phosphotransferase enzyme family C7M26_04039 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) C7M26_04040 ENOG4105C8F Beta-lactamase domain protein C7M26_04041 ENOG4105C6K Malic enzyme C7M26_04044 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ C7M26_04047 ENOG4108VDD TRNA binding domain protein C7M26_04049 ENOG4105DFU Cell wall formation (By similarity) C7M26_04053 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase C7M26_04054 ENOG4105ETE Transcriptional regulator (LacI family C7M26_04055 ENOG4107R0U MotA TolQ exbB proton channel C7M26_04056 ENOG4105ER2 Ompa motb domain protein C7M26_04057 ENOG4105DGU Histone deacetylase C7M26_04058 ENOG4105W87 Cbs domain C7M26_04059 ENOG4105F1V Acetoin utilization protein C7M26_04061 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C7M26_04063 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) C7M26_04064 ENOG4105BZU Histidine kinase C7M26_04066 ENOG4105U5Y Transcriptional regulator C7M26_04073 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C7M26_04074 ENOG4105EFZ amidohydrolase C7M26_04075 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C7M26_04076 ENOG4105D07 Signal peptide peptidase, SppA C7M26_04077 ENOG4105VK3 rdd domain containing protein C7M26_04079 ENOG4105KBJ sporulation protein ytfj C7M26_04080 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) C7M26_04082 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) C7M26_04083 ENOG4105EPU Molybdenum cofactor synthesis domain protein C7M26_04084 ENOG4105CDH Citrulline--aspartate ligase C7M26_04085 ENOG4105CH7 arginosuccinase C7M26_04088 ENOG4105E8R UPF0173 metal-dependent hydrolase C7M26_04089 ENOG4108KSA LysR family transcriptional regulator C7M26_04090 ENOG4108XSB acetyltransferase, (GNAT) family C7M26_04095 ENOG4105CDA abc transporter atp-binding protein C7M26_04096 ENOG4105DEN Luciferase family C7M26_04100 ENOG4105CH2 amidohydrolase C7M26_04101 ENOG410635A Membrane C7M26_04104 ENOG4105SFS phosphoesterase RecJ domain protein C7M26_04105 ENOG4106EVM C7M26_04107 ENOG4105VV2 C7M26_04108 ENOG4105C0B DNA polymerase III (alpha subunit) C7M26_04109 ENOG4105C6K Malic enzyme C7M26_04110 ENOG4108IEY Carboxyl transferase domain C7M26_04112 ENOG4105CTQ phosphohexokinase C7M26_04113 ENOG4105CA9 Pyruvate kinase C7M26_04114 ENOG4105FS0 cytoplasmic membrane protein C7M26_04115 ENOG4108REF Sporulation integral membrane protein ytvi C7M26_04117 ENOG4105BZN citrate synthase C7M26_04118 ENOG4108HMX isocitrate dehydrogenase (NADP) C7M26_04119 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C7M26_04120 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C7M26_04121 ENOG4105BZU Histidine kinase C7M26_04122 ENOG4105C2M dna polymerase I C7M26_04123 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) C7M26_04125 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) C7M26_04126 ENOG4105CV8 reductase C7M26_04127 ENOG4105F27 Major Facilitator C7M26_04128 ENOG4105KVH Transcriptional regulator C7M26_04129 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C7M26_04130 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) C7M26_04131 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) C7M26_04135 ENOG4108TDW sporulation protein YtxC C7M26_04137 ENOG4105C22 threonyL-tRNA synthetase C7M26_04139 ENOG4108HRK Histidine kinase C7M26_04140 ENOG4105DY9 regulatoR C7M26_04142 ENOG41067MG lrgb family C7M26_04144 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) C7M26_04145 ENOG4105VJV 50s ribosomal protein L35 C7M26_04146 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) C7M26_04147 ENOG410696E Membrane C7M26_04149 ENOG4105CN9 Peptidase m42 family protein C7M26_04150 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase C7M26_04152 ENOG4105EF1 ribulokinase C7M26_04153 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase C7M26_04155 ENOG4108MDK Dehydrogenase C7M26_04158 ENOG4105DRS transport system, permease C7M26_04159 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) C7M26_04162 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C7M26_04163 ENOG4105CQB FAD linked oxidase domain protein C7M26_04165 ENOG41067MF small acid-soluble spore protein C7M26_04166 ENOG4108RWN rrna methyltransferase C7M26_04167 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) C7M26_04168 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) C7M26_04169 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C7M26_04172 ENOG4105DCG PHP domain protein C7M26_04173 ENOG4105C98 muts2 protein C7M26_04175 ENOG4105CEY Amp-dependent synthetase and ligase C7M26_04176 ENOG4107Z3H Transcriptional regulator, TetR family C7M26_04177 ENOG41060WC Enoyl-CoA hydratase C7M26_04178 ENOG4105BZJ Electron transfer flavoprotein C7M26_04179 ENOG4105C10 Electron transfer flavoprotein C7M26_04181 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) C7M26_04182 ENOG4105K63 Thioredoxin C7M26_04183 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) C7M26_04184 ENOG4105CFH Aspartokinase C7M26_04186 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit C7M26_04188 ENOG4105E33 succinate dehydrogenase C7M26_04190 ENOG4105PFC Transcriptional regulator C7M26_04191 ENOG41067TZ transcriptional regulator, MarR family C7M26_04192 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) C7M26_04193 ENOG4108XJQ germination protein C7M26_04194 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) C7M26_04195 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) C7M26_04196 ENOG4105M59 Phosphodiesterase, mj0936 family C7M26_04198 ENOG4107KM7 Heat induced stress protein YflT C7M26_04199 ENOG4105I4A GCN5-related N-acetyltransferase C7M26_04201 ENOG4105C7K acetolactate synthase C7M26_04202 ENOG4108ZP8 Acetolactate synthase small subunit C7M26_04203 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase C7M26_04204 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) C7M26_04205 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C7M26_04206 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C7M26_04207 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C7M26_04209 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation C7M26_04210 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) C7M26_04211 ENOG4108IUQ atp-dependent protease C7M26_04212 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) C7M26_04213 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) C7M26_04215 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) C7M26_04217 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) C7M26_04219 ENOG4105D52 delta-aminolevulinic acid dehydratase C7M26_04220 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase C7M26_04221 ENOG41068KH stage VI sporulation protein D C7M26_04222 ENOG4106AR7 Spore coat protein C7M26_04224 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) C7M26_04225 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase C7M26_04226 ENOG4106A3R peptidase C7M26_04228 ENOG4108Z03 MAF-like protein C7M26_04229 ENOG4105W5Q DNA repair protein (RadC C7M26_04230 ENOG4105DFF Rod shape-determining protein mreb C7M26_04232 ENOG4105YHC Rod shape-determining protein MreD C7M26_04233 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) C7M26_04234 ENOG4107QMS site-determining protein C7M26_04237 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) C7M26_04238 ENOG4105X36 (ribosomal) protein C7M26_04239 ENOG4105K46 50S ribosomal protein l27 C7M26_04241 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control C7M26_04242 ENOG41090I5 UPF0735 ACT domain-containing protein C7M26_04243 ENOG4105CQC Prephenate dehydratase C7M26_04246 ENOG4108IYU L-aspartate oxidase C7M26_04247 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase C7M26_04248 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) C7M26_04249 ENOG4106678 morphogenetic protein associated with SpoVID C7M26_04251 ENOG4105CDY transcriptional regulatory protein C7M26_04252 ENOG4105BZG amino acid carrier protein C7M26_04256 ENOG4105CK5 oxidoreductase C7M26_04257 ENOG4105IE8 Alpha-ketoglutarate permease C7M26_04259 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) C7M26_04260 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) C7M26_04261 ENOG41061AI Protein of unknown function (DUF2905) C7M26_04262 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) C7M26_04263 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) C7M26_04264 ENOG4105VIE preprotein translocase, subunit YajC C7M26_04265 ENOG4105NAP C7M26_04266 ENOG4108QG2 Membrane C7M26_04267 ENOG4105CKP Polysaccharide Biosynthesis Protein C7M26_04269 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C7M26_04270 ENOG4105NCW Trka-c domain protein C7M26_04271 ENOG41067VP Protein of unknown function (DUF1049) C7M26_04272 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) C7M26_04273 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) C7M26_04274 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) C7M26_04276 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C7M26_04278 ENOG4105CUT histidyl-tRNA synthetase C7M26_04279 ENOG4105C9M aspartyl-trna synthetase C7M26_04280 ENOG4105CUZ uba thif-type nad fad binding protein C7M26_04281 ENOG4105D1H recombination factor protein RarA C7M26_04283 ENOG4105C3J Cysteine desulfurase C7M26_04284 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) C7M26_04286 ENOG4105C7H Helicase, RecD TraA family C7M26_04288 ENOG41060CR C7M26_04290 ENOG4105DRP amino acid AbC transporter C7M26_04291 ENOG4105EAD ABC transporter C7M26_04292 ENOG4105CT1 (ABC) transporter C7M26_04293 ENOG4105CDA abc transporter atp-binding protein C7M26_04294 ENOG4105C02 permease C7M26_04295 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C7M26_04296 ENOG4105VBH UPF0297 protein C7M26_04297 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) C7M26_04298 ENOG4105VPH UPF0473 protein C7M26_04299 ENOG4105HHA aminodeoxychorismate lyase C7M26_04301 ENOG4105XYU peptidase (U32 family) C7M26_04302 ENOG4105CFP Peptidase U32 C7M26_04303 ENOG4105DBI uridine monophosphokinase C7M26_04304 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) C7M26_04305 ENOG4107XRG penicillin-binding protein C7M26_04308 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) C7M26_04311 ENOG4105C28 cystathionine C7M26_04314 ENOG4108JB9 formate dehydrogenase C7M26_04315 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) C7M26_04317 ENOG4105TMB Formate nitrite transporter C7M26_04321 ENOG41082JN Transcriptional regulator C7M26_04322 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C7M26_04323 ENOG4105WDR C7M26_04324 ENOG4105EXC Acyl-transferase C7M26_04325 ENOG4108P49 AntiSigma factor C7M26_04326 ENOG4105JVQ RNA Polymerase C7M26_04327 ENOG4108NGU Transcriptional regulator C7M26_04328 ENOG4105N14 lysine exporter protein LysE YggA C7M26_04329 ENOG4105C85 amino acid