locus-tag class description C7M27_00003 ENOG4107RSM transcriptional regulator C7M27_00005 ENOG4107FQX Alpha-acetolactate decarboxylase C7M27_00006 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein C7M27_00009 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator C7M27_00010 ENOG4105CNN ABC, transporter C7M27_00011 ENOG4105C2J ABC transporter C7M27_00012 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) C7M27_00013 ENOG4108RVA ribokinase C7M27_00014 ENOG4105ETE Transcriptional regulator (LacI family C7M27_00015 ENOG4105N98 Capsule biosynthesis protein capB C7M27_00017 ENOG4105PNM synthesis protein C7M27_00019 ENOG4105K4H Nlp p60 protein C7M27_00020 ENOG4105J7I hydrolase C7M27_00021 ENOG4108KGH TRANSCRIPTIONal C7M27_00022 ENOG4105C54 Major Facilitator superfamily C7M27_00023 ENOG4108NHD germination protein C7M27_00026 ENOG4105DG6 mannose-6-phosphate isomerase C7M27_00043 ENOG4105EY8 ABC transporter C7M27_00044 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C7M27_00047 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase C7M27_00050 ENOG4105JFG SpoIID LytB domain protein C7M27_00051 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C7M27_00052 ENOG4105D3Q Sugar transferase C7M27_00053 ENOG4105PSV Polysaccharide Biosynthesis Protein C7M27_00054 ENOG4107RA4 Glycosyl transferase (Group 1 C7M27_00055 ENOG4105C6Y Udp-glucose 6-dehydrogenase C7M27_00056 ENOG4105QZI O-Antigen Polymerase C7M27_00059 ENOG4107EF8 Glycosyl transferase (Group 1 C7M27_00060 ENOG4105ESV Glycosyl transferase, family 4 C7M27_00061 ENOG4108KGH TRANSCRIPTIONal C7M27_00062 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein C7M27_00063 ENOG4105BZU Histidine kinase C7M27_00064 ENOG4105WH1 Two component transcriptional regulator luxr family C7M27_00068 ENOG41081UC Inherit from COG: Competence protein C7M27_00069 ENOG4105RU3 C7M27_00072 ENOG4105E1Q flagellar hook-associated protein C7M27_00073 ENOG4105DTJ flagellar hook-associated protein C7M27_00074 ENOG4105MKD C7M27_00075 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) C7M27_00076 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) C7M27_00077 ENOG4105I03 Flagellin C7M27_00078 ENOG41083S7 flagellar protein FlaG C7M27_00079 ENOG4107RT6 flagellar hook-associated C7M27_00080 ENOG4105MQ3 flagellar protein FliS C7M27_00083 ENOG4105MS2 ribosomal subunit Interface protein C7M27_00085 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) C7M27_00088 ENOG4105CAK Cell division ATP-binding protein ftsE C7M27_00089 ENOG4105CRP Part of the ABC transporter FtsEX involved in C7M27_00090 ENOG4105CN1 protease C7M27_00094 ENOG4105MKU Transcriptional regulator C7M27_00097 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) C7M27_00098 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) C7M27_00102 ENOG4108PY7 C7M27_00103 ENOG41067S9 phage shock protein C, PspC C7M27_00104 ENOG41086DT Membrane protein of unknown function C7M27_00107 ENOG410625E C7M27_00108 ENOG4106A3M Cytochrome p-450 C7M27_00110 ENOG41088CQ domain protein C7M27_00112 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) C7M27_00113 ENOG4105CE4 GlcNAc 6-P deacetylase C7M27_00114 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) C7M27_00115 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) C7M27_00116 ENOG4105HKU nucleoside recognition domain-containing protein C7M27_00117 ENOG4107XGZ Hydrolase C7M27_00118 ENOG4108S4C acetyltransferase C7M27_00119 ENOG4108E16 pectate lyase C7M27_00121 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) C7M27_00122 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) C7M27_00123 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) C7M27_00124 ENOG4105ECC imidazole-glycerol-phosphate dehydratase C7M27_00125 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) C7M27_00126 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase C7M27_00127 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) C7M27_00128 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase C7M27_00130 ENOG4106FGC C7M27_00132 ENOG4105BZ1 (ABC) transporter C7M27_00135 ENOG4105C3M thioredoxin reductase C7M27_00136 ENOG4108Z4K mutator MutT protein C7M27_00137 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) C7M27_00138 ENOG4105CHW UPF0052 protein C7M27_00139 ENOG4105CIE May be required for sporulation (By similarity) C7M27_00140 ENOG4105KRI phosphocarrier protein (HPr C7M27_00141 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase C7M27_00142 ENOG4107A6P C7M27_00144 ENOG4105EWM Histidine kinase C7M27_00145 ENOG4105C19 ABC transporter C7M27_00147 ENOG4105C5I Dehydrogenase C7M27_00148 ENOG4108V2W Carbonate dehydratase C7M27_00149 ENOG4105CHH sulfate transporter C7M27_00150 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain C7M27_00151 ENOG4108URH decarboxylase C7M27_00152 ENOG4105FKQ transcriptional regulator C7M27_00153 ENOG4108IUK alpha amylase, catalytic C7M27_00154 ENOG4107FKK extracellular solute-binding protein family 1 C7M27_00155 ENOG4105D56 permease protein C7M27_00156 ENOG4105EG2 ABC transporter, permease C7M27_00159 ENOG4105CG3 alpha amylase, catalytic region C7M27_00160 ENOG4107URF beta-phospho-glucomutase C7M27_00161 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C7M27_00167 ENOG4107QTZ amino acid C7M27_00168 ENOG4108HKT sucrose-6-phosphate hydrolase C7M27_00169 ENOG4105EDQ levansucrase EC 2.4.1.10 C7M27_00170 ENOG4105FQP Beta-lactamase C7M27_00172 ENOG4105NI3 Protein of unknown function (DUF3237) C7M27_00173 ENOG4105PY6 Phenolic acid decarboxylase C7M27_00175 ENOG4105EBR Carboxylesterase C7M27_00177 ENOG4105HTX biosynthesis protein C7M27_00178 ENOG4108QV3 biosynthesis protein C7M27_00180 ENOG4108PQP glycosyl transferase group 1 C7M27_00181 ENOG4105K64 Glycosyl transferase, family 2 C7M27_00182 ENOG4108KMV Glycosyl transferase (Group 1 C7M27_00183 ENOG41068W6 Capsular polysaccharide biosynthesis protein C7M27_00184 ENOG4107QRS glycosyltransferase group 2 family protein C7M27_00186 ENOG4105K64 Glycosyl transferase, family 2 C7M27_00188 ENOG4105D3Q Sugar transferase C7M27_00189 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family C7M27_00190 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C7M27_00191 ENOG4108ZPC Polysaccharide pyruvyl transferase C7M27_00193 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C7M27_00194 ENOG4105DAA L-lactate C7M27_00195 ENOG4105JXH GntR family transcriptional regulator C7M27_00197 ENOG4107FKK extracellular solute-binding protein family 1 C7M27_00199 ENOG4105EG2 ABC transporter, permease C7M27_00202 ENOG4108MJI response regulator C7M27_00203 ENOG4107R6F Alpha Beta Hydrolase Fold protein C7M27_00205 ENOG4108M15 ABC transporter C7M27_00206 ENOG4105KCT ABC transporter C7M27_00207 ENOG4105BZU Histidine kinase C7M27_00211 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C7M27_00212 ENOG4107QR9 Iron-sulfur cluster binding protein C7M27_00213 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) C7M27_00214 ENOG4105VRS hydrolase family 18 C7M27_00216 ENOG4107RT3 EamA-like transporter family C7M27_00217 ENOG4105GZI Transcriptional regulator C7M27_00218 ENOG4105DEN Luciferase family C7M27_00219 ENOG4105CMD Transcriptional regulator, GntR family C7M27_00222 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C7M27_00223 ENOG4105BZA Phosphoglycerate kinase C7M27_00224 ENOG4105CP7 Triose-phosphate isomerase C7M27_00225 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) C7M27_00226 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) C7M27_00227 ENOG4108W0I acetyltransferase C7M27_00228 ENOG4105T65 Membrane-associated protein C7M27_00230 ENOG4108QCI YvbH-like oligomerisation region C7M27_00231 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein C7M27_00232 ENOG4107HG4 Transcriptional regulator C7M27_00233 ENOG4108IJ8 ABC transporter C7M27_00234 ENOG4105E90 ABC transporter C7M27_00235 ENOG4108HQR Glycine betaine C7M27_00236 ENOG4105R40 Glycine betaine carnitine choline C7M27_00237 ENOG4107HG4 Transcriptional regulator C7M27_00238 ENOG4108IJ8 ABC transporter C7M27_00239 ENOG4105E90 ABC transporter C7M27_00240 ENOG4108HQR Glycine betaine C7M27_00241 ENOG4105R40 Glycine betaine carnitine choline C7M27_00247 ENOG4105DA5 (ABC) transporter C7M27_00252 ENOG4105C8Q Methyl-accepting chemotaxis C7M27_00253 ENOG4105KVH Transcriptional regulator C7M27_00258 ENOG4105XZU Preprotein translocase, subunit SecG C7M27_00260 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) C7M27_00261 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) C7M27_00263 ENOG4105EWI Short-chain dehydrogenase reductase Sdr C7M27_00264 ENOG4105KBX Transcriptional regulator, TetR family C7M27_00265 ENOG4105KPY Small multidrug resistance protein C7M27_00266 ENOG4105RXJ C7M27_00267 ENOG4105ME7 Membrane C7M27_00268 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C7M27_00269 ENOG4105D9R oxidoreductase C7M27_00270 ENOG4105VPX protein, conserved in bacteria C7M27_00271 ENOG410681U heavy metal transport detoxification protein C7M27_00272 ENOG4105C59 p-type ATPase C7M27_00273 ENOG4105C59 p-type ATPase C7M27_00274 ENOG4107ZQN disulfide bond C7M27_00276 ENOG4105EN6 Membrane C7M27_00278 ENOG4105EEM helicase C7M27_00279 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C7M27_00280 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) C7M27_00281 ENOG4105EEQ Na H antiporter C7M27_00284 ENOG4105E0C molybdate abc transporter C7M27_00285 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein C7M27_00286 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family C7M27_00287 ENOG4107QZ2 Sulfatase C7M27_00288 ENOG4107K5X Membrane-bound metal-dependent hydrolase C7M27_00290 ENOG4105D5Q Arginine ornithine antiporter C7M27_00293 ENOG4105DQ5 transport system permease protein C7M27_00294 ENOG4105EHG Permease protein C7M27_00295 ENOG4105E0A ABC, transporter C7M27_00296 ENOG4108WMK Efflux transporter RND family MFP subunit C7M27_00297 ENOG4105C19 ABC transporter C7M27_00298 ENOG4107RBB ABC transporter, permease C7M27_00300 ENOG4105F0F Oxalate decarboxylase C7M27_00302 ENOG4106DF4 Sigma-70, region 4 C7M27_00304 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C7M27_00306 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein C7M27_00307 ENOG4105EWI Short-chain dehydrogenase reductase Sdr C7M27_00308 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) C7M27_00309 ENOG4105EHG Permease protein C7M27_00310 ENOG4105E0A ABC, transporter C7M27_00311 ENOG4108WBT adenosyltransferase C7M27_00314 ENOG41087YS Phage shock protein A C7M27_00317 ENOG4105ENE Histidine kinase C7M27_00318 ENOG4105WH1 Two component transcriptional regulator luxr family C7M27_00323 ENOG4105C9Q fumarate hydratase class II C7M27_00324 ENOG41067SE Tetr family transcriptional regulator C7M27_00325 ENOG4105F3H Histidine kinase C7M27_00327 ENOG4105C0H protease C7M27_00328 ENOG4105HUF DNA protection during starvation protein C7M27_00329 ENOG4105E1F short-chain dehydrogenase reductase C7M27_00332 ENOG4105E0A ABC, transporter C7M27_00334 ENOG4105EGI Transcriptional regulator C7M27_00336 ENOG4105MDS 4-oxalocrotonate tautomerase C7M27_00337 ENOG4105C0R drug resistance transporter emrb qaca subfamily C7M27_00338 ENOG41067TZ transcriptional regulator, MarR family C7M27_00344 ENOG4105CHU acetyl-coa acetyltransferase C7M27_00345 ENOG4105C1G acyl-Coa dehydrogenase C7M27_00346 ENOG41080E8 Transcriptional regulator, Spx MgsR family C7M27_00347 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) C7M27_00352 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C7M27_00353 ENOG4108UMI ABC transporter, permease C7M27_00354 ENOG4105D01 (LipO)protein C7M27_00356 ENOG4105C3K feS assembly ATPase SufC C7M27_00357 ENOG4105JRK feS assembly protein SufD C7M27_00358 ENOG4105C9B Cysteine desulfurase C7M27_00359 ENOG4108UNV SUF system FeS assembly protein, NifU family C7M27_00360 ENOG4105DIW FeS assembly protein SUFB C7M27_00361 ENOG4105NPE arsR family transcriptional regulator C7M27_00362 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase C7M27_00365 ENOG4107VFR oxidoreductase C7M27_00366 ENOG4105PKS Excinuclease abc c subunit domain protein C7M27_00367 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine C7M27_00368 ENOG4105XN3 extracellular solute-binding protein family 1 C7M27_00369 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component C7M27_00370 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component C7M27_00371 ENOG4108KPW sugar kinase C7M27_00372 ENOG4105FDP GntR family transcriptional regulator C7M27_00373 ENOG4108IJ9 (ABC) transporter C7M27_00374 ENOG4108K8S endonuclease I C7M27_00376 ENOG4105C5R Aminotransferase C7M27_00377 ENOG4105XRQ Xanthine dehydrogenase accessory factor C7M27_00380 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding C7M27_00381 ENOG4107YV9 domain protein C7M27_00383 ENOG4105VT2 5-hydroxyisourate hydrolase C7M27_00384 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) C7M27_00387 ENOG4105G9B Transcriptional regulator C7M27_00388 ENOG4105CD3 dihydroorotase C7M27_00390 ENOG4105I3N Conserved Protein C7M27_00392 ENOG4107R8B 5'-nucleotidase C7M27_00393 ENOG4105KZD Domain of unknown function (DUF1805) C7M27_00394 ENOG4108YTE sporulation protein YunB C7M27_00395 ENOG4105FAA peptidase M23 C7M27_00396 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) C7M27_00397 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) C7M27_00398 ENOG4105MMD transcriptional regulator C7M27_00400 ENOG4105D4U had-superfamily hydrolase, subfamily iia C7M27_00401 ENOG4108W5N phosphatidylglycerophosphatase a C7M27_00403 ENOG4105D6E homoserine dehydrogenase C7M27_00404 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) C7M27_00405 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) C7M27_00406 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein C7M27_00407 ENOG41083MR nifu domain-containing protein C7M27_00410 ENOG4105ZKE UPF0349 protein C7M27_00413 ENOG4108YX9 iron--sulfur cluster insertion protein erpA C7M27_00414 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 C7M27_00418 ENOG4105CAY ferredoxin--nadp reductase C7M27_00419 ENOG4105CEP NADH dehydrogenase C7M27_00421 ENOG41069ER domain protein C7M27_00423 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) C7M27_00427 ENOG4105NIV Esterase C7M27_00428 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase C7M27_00429 ENOG4105E4F Isochorismate synthase C7M27_00430 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase C7M27_00431 ENOG4105WQI isochorismatase C7M27_00432 ENOG4105CEY Amp-dependent synthetase and ligase C7M27_00433 ENOG4105WQT MbtH domain protein C7M27_00435 ENOG4105DCF alanine dehydrogenase C7M27_00436 ENOG4108K8K Transcriptional regulator C7M27_00443 ENOG410904N short-chain dehydrogenase reductase C7M27_00447 ENOG4105C02 permease C7M27_00452 ENOG4105DAP Nicotinate phosphoribosyltransferase C7M27_00453 ENOG4105D58 Diguanylate phosphodiesterase C7M27_00458 ENOG4105BZU Histidine kinase C7M27_00460 ENOG4105KA0 thioesterase Superfamily protein C7M27_00461 ENOG4105KJM monovalent cation h antiporter subunit g C7M27_00463 ENOG4105SC1 monovalent cation H antiporter subunit E C7M27_00464 ENOG4108JPZ Monovalent cation H antiporter subunit D C7M27_00465 ENOG4108ZE9 Monovalent cation H antiporter subunit C C7M27_00466 ENOG4105HC0 Na H antiporter C7M27_00467 ENOG4105D65 subunit l C7M27_00471 ENOG4105UIB (ABC) transporter C7M27_00472 ENOG4108JQ9 ABC transporter C7M27_00473 ENOG4105DIH basic membrane C7M27_00474 ENOG4108MRH transcriptional regulatory protein C7M27_00477 ENOG4105KIR Thiol-disulfide oxidoreductase dcc C7M27_00478 ENOG4105BZ4 penicillin-binding protein C7M27_00482 ENOG4105Y38 Kinase-associated protein B C7M27_00483 ENOG4108HGU Histidine kinase C7M27_00484 ENOG4105C87 Aminotransferase class I and II C7M27_00486 ENOG4108MUZ hydrolase C7M27_00487 ENOG4108ZB6 transcriptional regulator AsnC family C7M27_00488 ENOG4105CHM Aminotransferase C7M27_00490 ENOG4105WG9 Conserved Protein C7M27_00491 ENOG4107QW4 alcohol dehydrogenase C7M27_00493 ENOG4107QYV phosphohexose isomerase C7M27_00496 ENOG4107PBV potassium channel C7M27_00497 ENOG4107PBV potassium channel C7M27_00500 ENOG4105C37 (CBS) domain C7M27_00502 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme C7M27_00505 ENOG4105C8Q Methyl-accepting chemotaxis C7M27_00506 ENOG4105C8Q Methyl-accepting chemotaxis C7M27_00507 ENOG4105C8Q Methyl-accepting chemotaxis C7M27_00508 ENOG4105C8Q Methyl-accepting chemotaxis C7M27_00510 ENOG4105E98 transcriptional regulator DeoR family C7M27_00511 ENOG4105DET Rhamnulokinase C7M27_00512 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) C7M27_00513 ENOG4105DKG l-rhamnose isomerase C7M27_00514 ENOG4105EE0 oxidoreductase C7M27_00516 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) C7M27_00520 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj C7M27_00521 ENOG4107I77 yiaA/B two helix domain C7M27_00522 ENOG4105CZN Potassium uptake protein C7M27_00525 ENOG4105TRT Transcriptional regulator C7M27_00527 ENOG4108JB8 alcohol dehydrogenase C7M27_00528 ENOG4108VNY MOSC domain protein C7M27_00529 ENOG4106DF1 C7M27_00531 ENOG4105DZ6 Band 7 protein C7M27_00532 ENOG4105VRR gCN5-related N-acetyltransferase C7M27_00533 ENOG4105N67 Proton-coupled thiamine transporter YuaJ C7M27_00559 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) C7M27_00561 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) C7M27_00564 ENOG4108KS4 Spore coat protein C7M27_00565 ENOG4107SBE Glycosyl transferase (Group 1 C7M27_00568 ENOG4107SBE Glycosyl transferase (Group 1 C7M27_00569 ENOG4108IAJ Nad-dependent epimerase dehydratase C7M27_00573 ENOG4105E4F Isochorismate synthase C7M27_00574 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) C7M27_00575 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) C7M27_00576 ENOG4108IPT Naphthoate synthase C7M27_00577 ENOG4105CEY Amp-dependent synthetase and ligase C7M27_00578 ENOG4105DTQ mandelate racemase muconate lactonizing C7M27_00579 ENOG4105DSE periplasmic solute binding protein C7M27_00580 ENOG4105DIK (ABC) transporter C7M27_00581 ENOG4105CC5 ABC transporter C7M27_00582 ENOG4105CC5 ABC transporter C7M27_00587 ENOG4108V2W Carbonate dehydratase C7M27_00588 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) C7M27_00591 ENOG4108RMU ferritin dps family protein C7M27_00594 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component C7M27_00596 ENOG4105D2X ABC transporter substrate-binding protein C7M27_00599 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase C7M27_00600 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP C7M27_00601 ENOG4105CAQ asparagine synthetase C7M27_00602 ENOG4105C85 amino acid C7M27_00603 ENOG4108Z0R Transferase C7M27_00604 ENOG4105E8V Alpha Beta Hydrolase Fold protein C7M27_00607 ENOG4105N5T Radical SAM Protein C7M27_00610 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family C7M27_00611 ENOG4105DVE abc transporter atp-binding protein C7M27_00614 ENOG4105C19 ABC transporter C7M27_00615 ENOG4107R34 abc transporter permease protein C7M27_00617 ENOG4105EWM Histidine kinase C7M27_00618 ENOG4105C19 ABC transporter C7M27_00620 ENOG4106UBQ C7M27_00621 ENOG410605W Major Facilitator C7M27_00622 ENOG4105BZU Histidine kinase C7M27_00624 ENOG4105C8T Leucyl-tRNA synthetase C7M27_00625 ENOG41085GJ domain protein C7M27_00631 ENOG4105NTD Inherit from COG: Hydrolase C7M27_00633 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C7M27_00634 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) C7M27_00636 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) C7M27_00637 ENOG4106A3M Cytochrome p-450 C7M27_00639 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component C7M27_00641 ENOG41075H3 AraC family transcriptional regulator C7M27_00643 ENOG4105F5H Glycosyl Hydrolase Family 88 C7M27_00645 ENOG4105DDC Oxidoreductase domain protein C7M27_00646 ENOG4105MU9 integral membrane protein C7M27_00648 ENOG4105C94 Transporter C7M27_00649 ENOG4105CBX hi0933 family C7M27_00652 ENOG4105YW5 deoR family transcriptional regulator C7M27_00655 ENOG4105C7N Xanthine uracil vitamin C permease C7M27_00656 ENOG4107QSE Dipeptidase C7M27_00657 ENOG4105C6T cysteine synthase C7M27_00658 ENOG4107F58 2'-5' rna ligase C7M27_00661 ENOG4108IUM Glycogen debranching enzyme C7M27_00662 ENOG4108V15 phosphotransferase enzyme family C7M27_00664 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) C7M27_00665 ENOG4105C8F Beta-lactamase domain protein C7M27_00666 ENOG4105C6K Malic enzyme C7M27_00669 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ C7M27_00672 ENOG4108VDD TRNA binding domain protein C7M27_00674 ENOG4105DFU Cell wall formation (By similarity) C7M27_00678 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase C7M27_00679 ENOG4105ETE Transcriptional regulator (LacI family C7M27_00680 ENOG4107R0U MotA TolQ exbB proton channel C7M27_00681 ENOG4105ER2 Ompa motb domain protein C7M27_00682 ENOG4105DGU Histone deacetylase C7M27_00683 ENOG4105W87 Cbs domain C7M27_00684 ENOG4105F1V Acetoin utilization protein C7M27_00686 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C7M27_00688 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) C7M27_00689 ENOG4105BZU Histidine kinase C7M27_00691 ENOG4105U5Y Transcriptional regulator C7M27_00698 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C7M27_00699 ENOG4105EFZ amidohydrolase C7M27_00700 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C7M27_00701 ENOG4105D07 Signal peptide peptidase, SppA C7M27_00702 ENOG4105VK3 rdd domain containing protein C7M27_00704 ENOG4105KBJ sporulation protein ytfj C7M27_00705 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) C7M27_00707 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) C7M27_00708 ENOG4105EPU Molybdenum cofactor synthesis domain protein C7M27_00709 ENOG4105CDH Citrulline--aspartate ligase C7M27_00710 ENOG4105CH7 arginosuccinase C7M27_00713 ENOG4105E8R UPF0173 metal-dependent hydrolase C7M27_00716 ENOG4105SFS phosphoesterase RecJ domain protein C7M27_00717 ENOG4106EVM C7M27_00719 ENOG4105VV2 C7M27_00720 ENOG4105C0B DNA polymerase III (alpha subunit) C7M27_00721 ENOG4105C6K Malic enzyme C7M27_00722 ENOG4108IEY Carboxyl transferase domain C7M27_00724 ENOG4105CTQ phosphohexokinase C7M27_00725 ENOG4105CA9 Pyruvate kinase C7M27_00726 ENOG4105FS0 cytoplasmic membrane protein C7M27_00727 ENOG4108REF Sporulation integral membrane protein ytvi C7M27_00729 ENOG4105BZN citrate synthase C7M27_00730 ENOG4108HMX isocitrate dehydrogenase (NADP) C7M27_00731 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C7M27_00732 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C7M27_00733 ENOG4105BZU Histidine kinase C7M27_00734 ENOG4105C2M dna polymerase I C7M27_00735 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) C7M27_00737 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) C7M27_00738 ENOG4105CV8 reductase C7M27_00739 ENOG4105F27 Major Facilitator C7M27_00740 ENOG4105KVH Transcriptional regulator C7M27_00741 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C7M27_00742 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) C7M27_00743 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) C7M27_00747 ENOG4108TDW sporulation protein YtxC C7M27_00749 ENOG4105C22 threonyL-tRNA synthetase C7M27_00751 ENOG4108HRK Histidine kinase C7M27_00752 ENOG4105DY9 regulatoR C7M27_00754 ENOG41067MG lrgb family C7M27_00756 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) C7M27_00757 ENOG4105VJV 50s ribosomal protein L35 C7M27_00758 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) C7M27_00759 ENOG410696E Membrane C7M27_00761 ENOG4105CN9 Peptidase m42 family protein C7M27_00762 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase C7M27_00764 ENOG4105EF1 ribulokinase C7M27_00765 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase C7M27_00767 ENOG4108MDK Dehydrogenase C7M27_00770 ENOG4105DRS transport system, permease C7M27_00771 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) C7M27_00774 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C7M27_00775 ENOG4105CQB FAD linked oxidase domain protein C7M27_00777 ENOG41067MF small acid-soluble spore protein C7M27_00778 ENOG4108RWN rrna methyltransferase C7M27_00779 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) C7M27_00780 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) C7M27_00781 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C7M27_00784 ENOG4105DCG PHP domain protein C7M27_00785 ENOG4105C98 muts2 protein C7M27_00787 ENOG4105CEY Amp-dependent synthetase and ligase C7M27_00788 ENOG4107Z3H Transcriptional regulator, TetR family C7M27_00789 ENOG41060WC Enoyl-CoA hydratase C7M27_00790 ENOG4105BZJ Electron transfer flavoprotein C7M27_00791 ENOG4105C10 Electron transfer flavoprotein C7M27_00793 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) C7M27_00794 ENOG4105K63 Thioredoxin C7M27_00795 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) C7M27_00796 ENOG4105CFH Aspartokinase C7M27_00798 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit C7M27_00800 ENOG4105E33 succinate dehydrogenase C7M27_00802 ENOG4105PFC Transcriptional regulator C7M27_00803 ENOG41067TZ transcriptional regulator, MarR family C7M27_00804 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) C7M27_00805 ENOG4108XJQ germination protein C7M27_00806 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) C7M27_00807 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) C7M27_00808 ENOG4105M59 Phosphodiesterase, mj0936 family C7M27_00810 ENOG4107KM7 Heat induced stress protein YflT C7M27_00811 ENOG4105I4A GCN5-related N-acetyltransferase C7M27_00813 ENOG4105C7K acetolactate synthase C7M27_00814 ENOG4108ZP8 Acetolactate synthase small subunit C7M27_00815 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase C7M27_00816 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) C7M27_00817 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C7M27_00818 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C7M27_00819 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C7M27_00821 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation C7M27_00822 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) C7M27_00823 ENOG4108IUQ atp-dependent protease C7M27_00824 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) C7M27_00825 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) C7M27_00827 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) C7M27_00829 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) C7M27_00831 ENOG4105D52 delta-aminolevulinic acid dehydratase C7M27_00832 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase C7M27_00833 ENOG41068KH stage VI sporulation protein D C7M27_00834 ENOG4106AR7 Spore coat protein C7M27_00836 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) C7M27_00837 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase C7M27_00838 ENOG4106A3R peptidase C7M27_00840 ENOG4108Z03 MAF-like protein C7M27_00841 ENOG4105W5Q DNA repair protein (RadC C7M27_00842 ENOG4105DFF Rod shape-determining protein mreb C7M27_00844 ENOG4105YHC Rod shape-determining protein MreD C7M27_00845 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) C7M27_00846 ENOG4107QMS site-determining protein C7M27_00849 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) C7M27_00850 ENOG4105X36 (ribosomal) protein C7M27_00851 ENOG4105K46 50S ribosomal protein l27 C7M27_00853 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control C7M27_00854 ENOG41090I5 UPF0735 ACT domain-containing protein C7M27_00855 ENOG4105CQC Prephenate dehydratase C7M27_00858 ENOG4108IYU L-aspartate oxidase C7M27_00859 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase C7M27_00860 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) C7M27_00861 ENOG4106678 morphogenetic protein associated with SpoVID C7M27_00863 ENOG4105CDY transcriptional regulatory protein C7M27_00864 ENOG4105BZG amino acid carrier protein C7M27_00868 ENOG4105CK5 oxidoreductase C7M27_00869 ENOG4105IE8 Alpha-ketoglutarate permease C7M27_00871 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) C7M27_00872 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) C7M27_00873 ENOG41061AI Protein of unknown function (DUF2905) C7M27_00874 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) C7M27_00875 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) C7M27_00876 ENOG4105VIE preprotein translocase, subunit YajC C7M27_00877 ENOG4105NAP C7M27_00878 ENOG4108QG2 Membrane C7M27_00879 ENOG4105CKP Polysaccharide Biosynthesis Protein C7M27_00881 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C7M27_00882 ENOG4105NCW Trka-c domain protein C7M27_00883 ENOG41067VP Protein of unknown function (DUF1049) C7M27_00884 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) C7M27_00885 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) C7M27_00886 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) C7M27_00888 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C7M27_00890 ENOG4105CUT histidyl-tRNA synthetase C7M27_00891 ENOG4105C9M aspartyl-trna synthetase C7M27_00892 ENOG4105CUZ uba thif-type nad fad binding protein C7M27_00893 ENOG4105D1H recombination factor protein RarA C7M27_00895 ENOG4105C3J Cysteine desulfurase C7M27_00896 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) C7M27_00898 ENOG4105C7H Helicase, RecD TraA family C7M27_00900 ENOG41060CR C7M27_00902 ENOG4105DRP amino acid AbC transporter C7M27_00903 ENOG4105EAD ABC transporter C7M27_00904 ENOG4105CT1 (ABC) transporter C7M27_00905 ENOG4105CDA abc transporter atp-binding protein C7M27_00906 ENOG4105C02 permease C7M27_00907 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C7M27_00908 ENOG4105VBH UPF0297 protein C7M27_00909 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) C7M27_00910 ENOG4105VPH UPF0473 protein C7M27_00911 ENOG4105HHA aminodeoxychorismate lyase C7M27_00913 ENOG4105XYU peptidase (U32 family) C7M27_00914 ENOG4105CFP Peptidase U32 C7M27_00915 ENOG4105DBI uridine monophosphokinase C7M27_00916 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) C7M27_00917 ENOG4107XRG penicillin-binding protein C7M27_00920 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) C7M27_00923 ENOG4105C28 cystathionine C7M27_00926 ENOG4108JB9 formate dehydrogenase C7M27_00927 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) C7M27_00928 ENOG4105TMB Formate nitrite transporter C7M27_00932 ENOG41082JN Transcriptional regulator C7M27_00933 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C7M27_00934 ENOG4105WDR C7M27_00935 ENOG4105EXC Acyl-transferase C7M27_00936 ENOG4108P49 AntiSigma factor C7M27_00937 ENOG4105JVQ RNA Polymerase C7M27_00938 ENOG4108NGU Transcriptional regulator C7M27_00939 ENOG4105N14 lysine exporter protein LysE YggA C7M27_00940 ENOG4105C85 amino acid C7M27_00941 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C7M27_00942 ENOG4105YHU PTS system C7M27_00943 ENOG4108IQ3 PTS system C7M27_00944 ENOG4105ETZ PTS System C7M27_00945 ENOG4105F3R pts system mannose fructose sorbose family iid C7M27_00946 ENOG4108HKT sucrose-6-phosphate hydrolase C7M27_00947 ENOG4108Z0Z intracellular protease Pfpi family C7M27_00948 ENOG4105DQ4 alcohol dehydrogenase C7M27_00950 ENOG4105VUF Transcriptional regulator C7M27_00953 ENOG4105E2A Dehydrogenase C7M27_00954 ENOG4105PGS Spore coat protein C7M27_00956 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase C7M27_00957 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein C7M27_00958 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein C7M27_00959 ENOG4108VQT Alpha beta hydrolase fold protein C7M27_00960 ENOG4105X5K response regulator receiver protein C7M27_00961 ENOG41083Q9 chitosanase C7M27_00962 ENOG4105CPC Aldo Keto reductase C7M27_00963 ENOG410904A RNA polymerase C7M27_00964 ENOG4108MEK Metal-binding protein YodA C7M27_00965 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes C7M27_00966 ENOG4105C0R drug resistance transporter emrb qaca subfamily C7M27_00968 ENOG4105CV1 Transketolase (EC 2.2.1.1) C7M27_00969 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) C7M27_00970 ENOG4105CHR reductase C7M27_00973 ENOG4107YCY Transcriptional regulator C7M27_00975 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) C7M27_00976 ENOG4105EA8 2-Nitropropane dioxygenase C7M27_00977 ENOG41075D4 Aminoglycoside 6-adenylyltransferase C7M27_00979 ENOG41064BW Protein of unknown function (DUF2568) C7M27_00982 ENOG41067XF inhibitor C7M27_00983 ENOG4108ZRZ Transcriptional regulator (AsnC family) C7M27_00984 ENOG4108UMN azlc family C7M27_00985 ENOG4105KMT branched-chain amino acid C7M27_00988 ENOG4105PGM cation diffusion facilitator family transporter C7M27_00989 ENOG4105H3G oxidoreductase C7M27_00990 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family C7M27_00993 ENOG4105C37 (CBS) domain C7M27_00996 ENOG41090E6 transcriptional regulator MERR family C7M27_00997 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein C7M27_00999 ENOG4105XTG Pfam:DUF156 C7M27_01000 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase C7M27_01001 ENOG4105VFE sira family C7M27_01002 ENOG4107TPS domain protein C7M27_01003 ENOG4105VFE sira family C7M27_01004 ENOG41087NI Sulfite exporter TauE/SafE C7M27_01005 ENOG41068VA C7M27_01006 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein C7M27_01007 ENOG4108UYN gCN5-related N-acetyltransferase C7M27_01008 ENOG4105DHF Membrane C7M27_01009 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C7M27_01010 ENOG4108SWU Histidine kinase C7M27_01012 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C7M27_01013 ENOG4105WFK nuclease C7M27_01016 ENOG41080BT SNARE associated Golgi C7M27_01017 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase C7M27_01020 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase C7M27_01021 ENOG4105CQW ribosome biogenesis GTPase YqeH C7M27_01022 ENOG4105E2X shikimate dehydrogenase C7M27_01023 ENOG410812S Rna-binding protein C7M27_01024 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) C7M27_01025 ENOG4108WF2 Metal Dependent Phosphohydrolase C7M27_01027 ENOG4108D32 Methyltransferase C7M27_01029 ENOG4105KQC Competence protein C7M27_01030 ENOG4108UK2 deaminase C7M27_01031 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 C7M27_01033 ENOG4105TQK DNA polymerase iii, delta' subunit C7M27_01034 ENOG41082YS Binds directly to 16S ribosomal RNA C7M27_01035 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) C7M27_01036 ENOG4108ZRV stage ii sporulation protein p C7M27_01038 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) C7M27_01039 ENOG4105CSA Coproporphyrinogen iii oxidase C7M27_01040 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) C7M27_01041 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ C7M27_01042 ENOG4105CFG Acts as a chaperone (By similarity) C7M27_01044 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) C7M27_01045 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) C7M27_01046 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C7M27_01049 ENOG4105KTH gatB Yqey C7M27_01050 ENOG4105F7J membrane-bound serine protease C7M27_01051 ENOG4105DI5 UPF0365 protein C7M27_01053 ENOG41068P3 sporulation protein YqfC C7M27_01054 ENOG4105EI1 sporulation protein yqfd C7M27_01055 ENOG4105C9A Phoh family C7M27_01057 ENOG4105CTJ Metal Dependent Phosphohydrolase C7M27_01058 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) C7M27_01059 ENOG4107YR5 Diacylglycerol kinase C7M27_01060 ENOG4105KG3 cytidine deaminase C7M27_01061 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) C7M27_01063 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) C7M27_01064 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit C7M27_01065 ENOG4105C38 Glycyl-tRNA synthetase beta subunit C7M27_01067 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) C7M27_01068 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 C7M27_01069 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) C7M27_01070 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C7M27_01073 ENOG4105EGD dinuclear metal center protein, YbgI family C7M27_01074 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) C7M27_01077 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) C7M27_01078 ENOG41069ZM Protein of unknown function (DUF2624) C7M27_01079 ENOG4108JYZ YitT family C7M27_01080 ENOG4105N80 Ferric uptake regulator, Fur family C7M27_01081 ENOG4108U5J '-nucleotidase C7M27_01082 ENOG41063Y9 C7M27_01083 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) C7M27_01086 ENOG4105SXS Protein of unknown function (DUF456) C7M27_01087 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C7M27_01089 ENOG4107RF6 penicillin-binding protein C7M27_01090 ENOG4105CVA phosphate C7M27_01091 ENOG4105C8U phosphate abc transporter C7M27_01092 ENOG4105E2Z phosphate ABC transporter (Permease C7M27_01093 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C7M27_01094 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C7M27_01095 ENOG41068DG YceG-like family C7M27_01100 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase C7M27_01102 ENOG4107ZXI Rhomboid family C7M27_01105 ENOG4105E0M Sulfatase C7M27_01110 ENOG4105C5X domain protein C7M27_01115 ENOG4105C37 (CBS) domain C7M27_01117 ENOG41080XP Cbs domain C7M27_01129 ENOG4105VFR signal peptidase C7M27_01131 ENOG4108IMY Transcriptional regulator C7M27_01134 ENOG4105C0D helicase C7M27_01135 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) C7M27_01136 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor C7M27_01137 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor C7M27_01138 ENOG4105WZW rhodanese family C7M27_01139 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) C7M27_01140 ENOG4105KST dependent repressor C7M27_01143 ENOG4105CBJ Metal-dependent enzyme C7M27_01145 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) C7M27_01146 ENOG4105DC7 peptidase M24 C7M27_01147 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) C7M27_01149 ENOG4105CD2 stage iii sporulation protein aa C7M27_01150 ENOG4105KR5 Stage iii sporulation protein C7M27_01151 ENOG4108CQH stage III sporulation protein AC C7M27_01152 ENOG4105KQ4 Stage iii sporulation protein ad C7M27_01154 ENOG410644B Stage III sporulation protein af C7M27_01158 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C7M27_01159 ENOG4108ZSR alkaline shock protein C7M27_01160 ENOG4105M7K Involved in the transcription termination process (By similarity) C7M27_01161 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) C7M27_01162 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C7M27_01163 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C7M27_01164 ENOG4105CTB Polyprenyl synthetase C7M27_01166 ENOG4105DX0 Hemolysin A C7M27_01167 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) C7M27_01168 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) C7M27_01169 ENOG4105S1Z Stage IV sporulation protein B C7M27_01170 ENOG4107QQR Sporulation C7M27_01172 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C7M27_01174 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C7M27_01175 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C7M27_01177 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C7M27_01178 ENOG4105C1G acyl-Coa dehydrogenase C7M27_01180 ENOG4105DXD 2-methylcitrate dehydratase C7M27_01181 ENOG4105CR4 methylisocitrate lyase C7M27_01182 ENOG4106CCJ Protein of unknown function (DUF2627) C7M27_01183 ENOG4108JUB Transcriptional regulator C7M27_01185 ENOG4107RDP Dehydrogenase C7M27_01186 ENOG4105CKM Branched-chain carboxylic acid kinase C7M27_01189 ENOG4105CPP Dehydrogenase, E1 component C7M27_01190 ENOG4105C7S Dehydrogenase C7M27_01193 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) C7M27_01194 ENOG4108Y6J UPF0403 protein C7M27_01195 ENOG4108HW3 (ABC) transporter C7M27_01196 ENOG4105E5Q amino acid AbC transporter C7M27_01197 ENOG4105CDA abc transporter atp-binding protein C7M27_01198 ENOG4108QEG Membrane C7M27_01199 ENOG4108VZI ErfK ybiS ycfS ynhG family protein C7M27_01201 ENOG4108ZVT methylmalonyl-coA epimerase C7M27_01202 ENOG4108HNZ carboxyl transferase C7M27_01203 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) C7M27_01204 ENOG4108NA0 Uncharacterized conserved protein (COG2071) C7M27_01205 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) C7M27_01207 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C7M27_01208 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) C7M27_01209 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase C7M27_01210 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) C7M27_01211 ENOG410861F 50S ribosomal protein L33 C7M27_01213 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C7M27_01215 ENOG4105II7 pyrroline-5-carboxylate reductase C7M27_01216 ENOG41069FQ Metallo-beta-lactamase superfamily C7M27_01217 ENOG4108IXY short-chain dehydrogenase reductase C7M27_01220 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase C7M27_01222 ENOG4105E5W Transporter C7M27_01224 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C7M27_01226 ENOG4108XET gCN5-related N-acetyltransferase C7M27_01227 ENOG4105KAC Antibiotic biosynthesis monooxygenase C7M27_01228 ENOG4105RHY Pfam:UPF0157 C7M27_01229 ENOG4106HZJ C7M27_01233 ENOG4105CPC Aldo Keto reductase C7M27_01235 ENOG4108YZ4 nudix hydrolase C7M27_01237 ENOG4108IMY Transcriptional regulator C7M27_01238 ENOG4105HDK L-asparaginase C7M27_01239 ENOG4108IJ0 Aspartate ammonia-lyase C7M27_01240 ENOG4105DFD Na H antiporter C7M27_01243 ENOG4105MZ9 stage II sporulation protein m C7M27_01244 ENOG4105I3K Ferric uptake regulator, Fur family C7M27_01246 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C7M27_01247 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) C7M27_01248 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) C7M27_01249 ENOG4105DZ1 carboxypeptidase C7M27_01250 ENOG41082AN stage II sporulation protein C7M27_01251 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) C7M27_01252 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C7M27_01255 ENOG41090VF Stage v sporulation protein ac C7M27_01256 ENOG4105CZ3 stage V sporulation protein ad C7M27_01258 ENOG4105G6R Stage v sporulation protein ae C7M27_01260 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) C7M27_01261 ENOG4105PTM secreted protein C7M27_01262 ENOG4107ZE5 PPIases accelerate the folding of proteins C7M27_01264 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) C7M27_01265 ENOG4105C3F Signal peptidase i C7M27_01267 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) C7M27_01268 ENOG4108R6K riboflavin synthase, subunit alpha C7M27_01269 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) C7M27_01270 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) C7M27_01273 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) C7M27_01274 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) C7M27_01276 ENOG4105DZ1 carboxypeptidase C7M27_01277 ENOG4108JIC nucleoside recognition domain protein C7M27_01279 ENOG4105FE9 pseudouridine synthase C7M27_01281 ENOG4107TWT Cytochrome c biogenesis protein C7M27_01282 ENOG4105CRE cytochrome C C7M27_01283 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C7M27_01284 ENOG4105BZU Histidine kinase C7M27_01287 ENOG4105FF2 Type I DHQase C7M27_01288 ENOG4108JQ1 Dehydrogenase C7M27_01289 ENOG4108SAX Membrane C7M27_01291 ENOG4105T7X C7M27_01292 ENOG4105C9U ATP-dependent DNA helicase RecQ C7M27_01293 ENOG4105I7S Abortive infection protein C7M27_01296 ENOG4107RGJ metallophosphoesterase C7M27_01299 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase C7M27_01300 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) C7M27_01302 ENOG4105MSI germination protein ypeb C7M27_01305 ENOG4105CAT Cytidine monophosphate kinase C7M27_01306 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) C7M27_01307 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) C7M27_01310 ENOG4105S2F C7M27_01311 ENOG41065D1 C7M27_01312 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) C7M27_01313 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase C7M27_01316 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) C7M27_01317 ENOG4105K70 DNA-binding protein C7M27_01318 ENOG4105EUJ GTP cyclohydrolase i C7M27_01320 ENOG4105XXQ heptaprenyl diphosphate synthase component I C7M27_01321 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) C7M27_01322 ENOG4105EAH synthase C7M27_01323 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) C7M27_01324 ENOG4105BZU Histidine kinase C7M27_01325 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase C7M27_01326 ENOG4105D49 3-dehydroquinate synthase C7M27_01327 ENOG4105KHN chorismate mutase C7M27_01328 ENOG4105CRQ synthase (Component I) C7M27_01329 ENOG4108I0Q anthranilate phosphoribosyltransferase C7M27_01331 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase C7M27_01332 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) C7M27_01336 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase C7M27_01337 ENOG41068YB TPR repeat-containing protein C7M27_01341 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) C7M27_01345 ENOG4108JYZ YitT family C7M27_01346 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase C7M27_01347 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) C7M27_01348 ENOG4108Z5K methylglyoxal synthase C7M27_01349 ENOG4105FJR Lmbe family C7M27_01350 ENOG4105CPK Glycosyl transferase (Group 1 C7M27_01351 ENOG4105DJ0 Poly(A) Polymerase C7M27_01352 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase C7M27_01353 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) C7M27_01354 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) C7M27_01355 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) C7M27_01356 ENOG4105DVT helicase C7M27_01357 ENOG4105YAC C7M27_01359 ENOG4105CHM Aminotransferase C7M27_01360 ENOG4105C5S asparaginyl-tRNA synthetase C7M27_01362 ENOG4105CSM endonuclease III C7M27_01364 ENOG4105BZ4 penicillin-binding protein C7M27_01374 ENOG4108I5C dEAD DEAH box helicase C7M27_01375 ENOG4107X2U Inherit from COG: Exonuclease-like protein C7M27_01376 ENOG4108UKS UPF0398 protein C7M27_01378 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) C7M27_01380 ENOG4105DVT helicase C7M27_01381 ENOG4105CHR reductase C7M27_01383 ENOG4108M60 Transcriptional regulator C7M27_01384 ENOG4105D7K pfkb domain protein C7M27_01385 ENOG4108UHU Aldolase C7M27_01386 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) C7M27_01387 ENOG4105CTD carboxy-peptidase C7M27_01388 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) C7M27_01389 ENOG4105C2W permease C7M27_01390 ENOG41065KQ synthase C7M27_01392 ENOG410890F Dynamin family C7M27_01397 ENOG41081VK Ribonuclease C7M27_01405 ENOG4105CVG Homoserine O-transsuccinylase C7M27_01406 ENOG4108V06 Glutathione peroxidase C7M27_01409 ENOG4105C01 Dihydroxy-acid dehydratase C7M27_01410 ENOG4108Y6J UPF0403 protein C7M27_01411 ENOG4107YX5 Pfam:DUF548 C7M27_01414 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) C7M27_01416 ENOG4108UT2 hemolysin iii C7M27_01418 ENOG4105C7B Threonine dehydratase C7M27_01420 ENOG4108KF3 Electron transport protein SCO1 SenC C7M27_01421 ENOG41090WU lipolytic protein G-D-S-L family C7M27_01422 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) C7M27_01426 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C7M27_01427 ENOG4105E0X reductase C7M27_01428 ENOG4105C5E polysaccharide biosynthesis protein C7M27_01433 ENOG4107Y9E nuclease C7M27_01436 ENOG4106BHF C7M27_01442 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C7M27_01447 ENOG4107R0E Glycosyl transferase, family 2 C7M27_01451 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase C7M27_01452 ENOG4105MYH C7M27_01459 ENOG4105E4C Lytic transglycosylase catalytic C7M27_01460 ENOG4105E4C Lytic transglycosylase catalytic C7M27_01469 ENOG41068G1 C7M27_01489 ENOG4105K70 DNA-binding protein C7M27_01490 ENOG4105ZUG C7M27_01492 ENOG4105ZUG C7M27_01494 ENOG41067QW Transcriptional regulator C7M27_01497 ENOG4108NE4 C7M27_01512 ENOG4107NTZ C7M27_01524 ENOG4107D0N C7M27_01525 ENOG4107D0N C7M27_01547 ENOG4105GJD protein, conserved in bacteria C7M27_01552 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) C7M27_01555 ENOG4108J9Q DNA ligase C7M27_01556 ENOG4108RAV Conserved protein C7M27_01563 ENOG4106YR8 C7M27_01564 ENOG41088HM C7M27_01566 ENOG4106PTB DnaB-like helicase C terminal domain C7M27_01567 ENOG4106IVX C7M27_01569 ENOG4106J9J DNA polymerase C7M27_01594 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) C7M27_01595 ENOG4107S45 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C7M27_01596 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C7M27_01598 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C7M27_01599 ENOG4106ITI Glutaredoxin C7M27_01601 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) C7M27_01607 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) C7M27_01617 ENOG4106Y37 Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity) C7M27_01619 ENOG4105C5E polysaccharide biosynthesis protein C7M27_01620 ENOG4107T32 3-phytase (EC 3.1.3.8) C7M27_01627 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C7M27_01630 ENOG4107S4Y M20 DapE family protein YgeY C7M27_01631 ENOG4108TSC N-acetyltransferase C7M27_01632 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein C7M27_01638 ENOG410841Q phosphoesterase PA-phosphatase related protein C7M27_01639 ENOG4106Z5R C7M27_01641 ENOG4105D3A purine nucleoside phosphorylase DeoD-type C7M27_01642 ENOG4108VXD carboxy-peptidase C7M27_01646 ENOG4105E1V na solute symporter C7M27_01649 ENOG4105FBA Phospholipase Carboxylesterase C7M27_01652 ENOG41090U3 tautomerase C7M27_01653 ENOG4105C6Z Gluconate C7M27_01654 ENOG4105C6Z Gluconate C7M27_01657 ENOG4105FR1 rard protein C7M27_01661 ENOG4106SCS STAS domain C7M27_01662 ENOG4107QMU Mate efflux family protein C7M27_01665 ENOG41087PP glycosyltransferase MGT family C7M27_01666 ENOG4105K4H Nlp p60 protein C7M27_01668 ENOG4105GMT ATPase associated with various cellular activities aaa_5 C7M27_01669 ENOG4107T89 von Willebrand factor, type A C7M27_01671 ENOG4105C7S Dehydrogenase C7M27_01672 ENOG4105C09 Bile acid C7M27_01673 ENOG4105C8J )-transporter C7M27_01674 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C7M27_01675 ENOG4105EWU Squalene--hopene cyclase C7M27_01676 ENOG4105C26 Dehydrogenase C7M27_01684 ENOG4105SCY DNAK suppressor C7M27_01685 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C7M27_01686 ENOG4105C9U ATP-dependent DNA helicase RecQ C7M27_01687 ENOG41069ER domain protein C7M27_01688 ENOG4108S01 response regulator C7M27_01689 ENOG4108ZGX Histidine kinase C7M27_01690 ENOG4105ECK Fatty Acid Desaturase C7M27_01694 ENOG4108SJC Membrane C7M27_01696 ENOG4105KTU Transcriptional regulator, arsr family C7M27_01698 ENOG4105D29 Helix-turn-helix type 11 domain protein C7M27_01700 ENOG4108W8B Beta-lactamase domain protein C7M27_01702 ENOG4108HJF gCN5-related N-acetyltransferase C7M27_01703 ENOG4105FTV AraC Family Transcriptional Regulator C7M27_01704 ENOG4108Z7R Chaperone CsaA C7M27_01707 ENOG4106BHF C7M27_01708 ENOG4106ANW SMI1_KNR4 C7M27_01712 ENOG4107T94 Endo-14-beta-xylanase C7M27_01713 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) C7M27_01716 ENOG4108J4B Beta-lactamase C7M27_01717 ENOG4108V4B ThiJ pfpI C7M27_01719 ENOG4108Q5Y Membrane C7M27_01721 ENOG4105NX3 Membrane C7M27_01722 ENOG4105VMP Transcriptional regulator C7M27_01724 ENOG41073R8 VanW family C7M27_01727 ENOG4105F0F Oxalate decarboxylase C7M27_01730 ENOG4108RAV Conserved protein C7M27_01731 ENOG4108NR7 pectate lyase C7M27_01732 ENOG4105XPP Protein of unknown function (DUF1275) C7M27_01733 ENOG4108YQE rare lipoprotein a C7M27_01735 ENOG4105EC8 Methyl-accepting chemotaxis C7M27_01739 ENOG4105ETE Transcriptional regulator (LacI family C7M27_01740 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) C7M27_01741 ENOG4105CIB oxidoreductase Domain protein C7M27_01742 ENOG4107QNK )-transporter C7M27_01744 ENOG4108J2R molybdopterin oxidoreductase C7M27_01745 ENOG4108M3J Dehydrogenase C7M27_01746 ENOG4107U6E carbohydrate kinase FGGY C7M27_01747 ENOG4105IE8 Alpha-ketoglutarate permease C7M27_01749 ENOG4105CJ1 ABC, transporter C7M27_01752 ENOG41068WN C7M27_01753 ENOG4108UB7 C7M27_01757 ENOG4105II7 pyrroline-5-carboxylate reductase C7M27_01758 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) C7M27_01759 ENOG4105C5Q Transcriptional regulator C7M27_01760 ENOG4105CBC glutamate synthase C7M27_01761 ENOG4105BZ8 glutamate synthase C7M27_01762 ENOG4105CB2 alcohol dehydrogenase C7M27_01763 ENOG4105SKE transcriptional Regulator LysR family C7M27_01764 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C7M27_01769 ENOG4107QJQ Mate efflux family protein C7M27_01770 ENOG4108N2V aldose 1-epimerase C7M27_01771 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family C7M27_01772 ENOG4105C0W non-ribosomal peptide synthetase C7M27_01774 ENOG4105C0W non-ribosomal peptide synthetase C7M27_01775 ENOG4105CEY Amp-dependent synthetase and ligase C7M27_01777 ENOG4106U2H Protein of unknown function (DUF1360) C7M27_01778 ENOG4105F32 YngK protein C7M27_01779 ENOG4105C1G acyl-Coa dehydrogenase C7M27_01780 ENOG4105CEY Amp-dependent synthetase and ligase C7M27_01781 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C7M27_01782 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit C7M27_01783 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase C7M27_01784 ENOG4105E39 Enoyl-CoA hydratase C7M27_01785 ENOG4107QX3 carboxylase C7M27_01787 ENOG4107T5V SNARE associated Golgi C7M27_01788 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C7M27_01790 ENOG4107SYN Glycosyl hydrolases family 43 C7M27_01791 ENOG4108MYR Secreted protein C7M27_01793 ENOG4107QWR cellulase (EC 3.2.1.4) C7M27_01798 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C7M27_01799 ENOG4105K4P CoA-binding domain protein C7M27_01800 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) C7M27_01801 ENOG4105W8X HesB YadR YfhF-family protein C7M27_01802 ENOG4105MI2 C7M27_01804 ENOG41067CD Small, acid-soluble spore protein Tlp C7M27_01807 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C7M27_01808 ENOG4108I0Z Aconitate hydratase C7M27_01810 ENOG4107DZX Small, acid-soluble spore protein P C7M27_01815 ENOG4107QIV Cytochrome c biogenesis protein C7M27_01819 ENOG4105CV1 Transketolase (EC 2.2.1.1) C7M27_01820 ENOG4105VPS UPF0291 protein C7M27_01821 ENOG4108SVB resolvase C7M27_01823 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) C7M27_01824 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) C7M27_01826 ENOG4105K7W phage-related replication protein C7M27_01828 ENOG4105FVX C7M27_01831 ENOG4108NHD germination protein C7M27_01832 ENOG4108Q8B Spore germination protein C7M27_01846 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) C7M27_01848 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C7M27_01849 ENOG4105C54 Major Facilitator superfamily C7M27_01850 ENOG4107Y9E nuclease C7M27_01851 ENOG4105CMG Carbohydrate kinase C7M27_01852 ENOG4105C93 Xylose Isomerase C7M27_01853 ENOG4105E2R ROK family C7M27_01854 ENOG4105DSG hydrolase family 43 C7M27_01855 ENOG4105CT4 transporter C7M27_01856 ENOG410907G C7M27_01859 ENOG4107AUC C7M27_01864 ENOG41079P0 C7M27_01866 ENOG4106BHF C7M27_01869 ENOG4105C5F glutamine synthetase C7M27_01870 ENOG4105KV4 Transcriptional regulator C7M27_01871 ENOG4105CXI aluminum resistance protein C7M27_01872 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) C7M27_01873 ENOG4106F1P AAA ATPase, central domain protein C7M27_01874 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C7M27_01875 ENOG4105U6W MutT NUDIX family protein C7M27_01876 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C7M27_01877 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C7M27_01878 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) C7M27_01881 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) C7M27_01882 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) C7M27_01886 ENOG410814C multidrug resistance protein C7M27_01887 ENOG4108X3M OsmC Ohr family protein C7M27_01888 ENOG4105K7W phage-related replication protein C7M27_01890 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C7M27_01893 ENOG4106A3M Cytochrome p-450 C7M27_01895 ENOG4105C0W non-ribosomal peptide synthetase C7M27_01897 ENOG4107SQU synthase C7M27_01898 ENOG4105C0W non-ribosomal peptide synthetase C7M27_01899 ENOG4108KQ6 Enoyl-CoA hydratase C7M27_01900 ENOG4108MGH Enoyl-CoA hydratase C7M27_01901 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase C7M27_01902 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase C7M27_01903 ENOG41062T2 Acyl carrier protein C7M27_01904 ENOG4107QKG PfaD family C7M27_01907 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C7M27_01908 ENOG4108151 Beta-lactamase domain protein C7M27_01909 ENOG4105W1N transcriptional regulator C7M27_01910 ENOG4105IIP Membrane C7M27_01913 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) C7M27_01914 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) C7M27_01917 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C7M27_01918 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) C7M27_01920 ENOG4105MCT stage V sporulation protein S C7M27_01921 ENOG4105D48 metallophosphoesterase C7M27_01922 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) C7M27_01923 ENOG4108A04 Beta-lactamase C7M27_01925 ENOG4105CEV competence damage-inducible protein C7M27_01926 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase C7M27_01929 ENOG4105XZV Protein of unknown function (DUF3243) C7M27_01930 ENOG4108RKS Short-chain dehydrogenase reductase Sdr C7M27_01934 ENOG4105FDP GntR family transcriptional regulator C7M27_01935 ENOG4105CNU cell division protein FtsK C7M27_01937 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit C7M27_01939 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C7M27_01941 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) C7M27_01942 ENOG4108S0H Dipicolinic acid synthetase, b subunit C7M27_01943 ENOG4105E35 Dipicolinate synthase subunit A C7M27_01945 ENOG4105C1V Peptidase, M16 C7M27_01947 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) C7M27_01948 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) C7M27_01949 ENOG4105DTN riboflavin biosynthesis protein ribF C7M27_01950 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) C7M27_01951 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) C7M27_01952 ENOG4105W7A Protein of unknown function (DUF503) C7M27_01953 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) C7M27_01954 ENOG4105VHM ribosomal protein C7M27_01955 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination C7M27_01956 ENOG4105CHV Transcription elongation factor NusA C7M27_01957 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) C7M27_01958 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) C7M27_01959 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) C7M27_01960 ENOG4105DZP Membrane-associated zinc metalloprotease C7M27_01962 ENOG4105KNE Phosphatidate cytidylyltransferase C7M27_01963 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) C7M27_01964 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) C7M27_01966 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) C7M27_01967 ENOG4105CE9 30S ribosomal protein S2 C7M27_01969 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C7M27_01972 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis C7M27_01973 ENOG4105CBS Chea signal transduction histidine kinase C7M27_01974 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) C7M27_01976 ENOG4105FZW flagellar biosynthesis regulator FlhF C7M27_01977 ENOG4105D7B Flagellar biosynthesis protein flha C7M27_01978 ENOG4105D00 flagellar biosynthetic protein flhB C7M27_01979 ENOG4105D19 Role in flagellar biosynthesis (By similarity) C7M27_01980 ENOG4105VS8 Flagellar biosynthetic protein fliq C7M27_01981 ENOG4105CN7 Flagellar biosynthetic protein FliP C7M27_01983 ENOG4107YTP response regulator receiver protein C7M27_01984 ENOG4105DD5 Flagellar motor switch protein C7M27_01985 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C7M27_01987 ENOG4108JQA flagellar C7M27_01988 ENOG410822I Flagellar hook capping protein C7M27_01989 ENOG410696Y Flagellar hook-length control protein C7M27_01991 ENOG4106YF4 Flagellar biosynthesis chaperone C7M27_01994 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C7M27_01995 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) C7M27_01996 ENOG4105VQ0 flagellar hook-basal body complex protein fliE C7M27_01997 ENOG4108ZC9 flagellar basal-body rod protein flgc C7M27_01998 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) C7M27_02000 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) C7M27_02001 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) C7M27_02002 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C7M27_02003 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) C7M27_02004 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) C7M27_02005 ENOG4105C79 DNA protecting protein DprA C7M27_02006 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha C7M27_02007 ENOG4105CMV Succinyl-CoA synthetase subunit beta C7M27_02008 ENOG4105VM1 flagellar C7M27_02010 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C7M27_02011 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) C7M27_02012 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) C7M27_02013 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) C7M27_02014 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) C7M27_02016 ENOG4108BW8 UPF0109 protein C7M27_02017 ENOG4105K5M 30s ribosomal protein S16 C7M27_02019 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) C7M27_02021 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) C7M27_02022 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) C7M27_02023 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) C7M27_02025 ENOG4105CHR reductase C7M27_02026 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C7M27_02028 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) C7M27_02029 ENOG4105CB5 ATP-dependent DNA helicase recG C7M27_02030 ENOG4105EJQ L-serine dehydratase C7M27_02032 ENOG4105DP4 dak2 domain fusion protein ylov C7M27_02033 ENOG4108ZAA Alkaline-shock protein C7M27_02034 ENOG4105VB9 50S ribosomal protein l28 C7M27_02035 ENOG4105FJ0 thiamine C7M27_02036 ENOG4105DJV ribulose-phosphate 3-epimerase C7M27_02037 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) C7M27_02038 ENOG4105D9P serine threonine protein kinase C7M27_02039 ENOG4108ZF3 Phosphatase C7M27_02040 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs C7M27_02041 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B C7M27_02042 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) C7M27_02043 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C7M27_02044 ENOG4105C25 Primosomal protein n' C7M27_02045 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase C7M27_02047 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) C7M27_02048 ENOG4105KC4 UPF0296 protein C7M27_02049 ENOG4105DSJ YicC domain protein C7M27_02052 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein C7M27_02053 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein C7M27_02054 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C7M27_02055 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) C7M27_02056 ENOG4107S4M Sulfate adenylate transferase C7M27_02058 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) C7M27_02060 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) C7M27_02061 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) C7M27_02062 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) C7M27_02063 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) C7M27_02064 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain C7M27_02065 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain C7M27_02067 ENOG4105CXT aspartate transcarbamylase C7M27_02069 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) C7M27_02070 ENOG4105C34 Pseudouridine synthase C7M27_02071 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) C7M27_02073 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) C7M27_02075 ENOG4105DBK s4 domain protein C7M27_02076 ENOG41067XK integral membrane protein C7M27_02077 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) C7M27_02078 ENOG4105DFA alanine racemase domain protein C7M27_02079 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase C7M27_02080 ENOG4105WR5 sporulation protein, YlmC YmxH family C7M27_02082 ENOG4105DKW ABC transporter C7M27_02084 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C7M27_02085 ENOG4105FFI sigma-e processing peptidase spoiiga C7M27_02087 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) C7M27_02088 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) C7M27_02089 ENOG4105K67 small basic protein C7M27_02091 ENOG4108R2U division initiation protein C7M27_02092 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) C7M27_02093 ENOG4105D4A Cell wall formation (By similarity) C7M27_02094 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) C7M27_02095 ENOG4105CNI cell division protein FtsW C7M27_02096 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) C7M27_02097 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) C7M27_02098 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) C7M27_02099 ENOG4105CJN penicillin-binding protein C7M27_02100 ENOG4105CJN penicillin-binding protein C7M27_02102 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) C7M27_02103 ENOG4108V6E Cell division protein mraZ C7M27_02109 ENOG4105KNH Nucleic acid-binding protein C7M27_02111 ENOG4105CDE UPF0348 protein C7M27_02112 ENOG41063PX domain protein C7M27_02113 ENOG4105D78 K07001 NTE family protein C7M27_02114 ENOG4105H20 Sporulation integral membrane protein YlbJ C7M27_02115 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) C7M27_02116 ENOG4106H78 methyltransferase C7M27_02117 ENOG4105WUC UPF0298 protein C7M27_02121 ENOG4106UY4 Inherit from COG: Scp-like extracellular C7M27_02122 ENOG41080XQ Signal transduction protein with cbs domains C7M27_02125 ENOG41064X9 cytochrome C oxidase subunit IV C7M27_02126 ENOG4105CCU oxidase (Subunit III) C7M27_02127 ENOG4105BZ9 Cytochrome C oxidase, subunit I C7M27_02129 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) C7M27_02131 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) C7M27_02132 ENOG4105CNI cell division protein FtsW C7M27_02133 ENOG4105ZPI UPF0358 protein C7M27_02134 ENOG4105CSV Glutaminase C7M27_02136 ENOG4108IAB Phoh family C7M27_02139 ENOG4105QA2 C7M27_02140 ENOG4105CI3 gtp-binding protein typa C7M27_02148 ENOG4105JQZ Methyltransferase C7M27_02150 ENOG4105ECY inositol monophosphatase C7M27_02153 ENOG4105WBI UPF0223 protein C7M27_02154 ENOG4105CXN decarboxylase C7M27_02156 ENOG4107QN2 dihydrolipoyl dehydrogenase C7M27_02157 ENOG4105C7S Dehydrogenase C7M27_02158 ENOG4105CPP Dehydrogenase, E1 component C7M27_02162 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C7M27_02163 ENOG4108X4Q Hydrolase C7M27_02165 ENOG4105CN5 Metallo-Beta-Lactamase C7M27_02167 ENOG4107ZYR domain protein C7M27_02169 ENOG4105BZU Histidine kinase C7M27_02174 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) C7M27_02175 ENOG4105C5H ABC transporter C7M27_02177 ENOG4105C3F Signal peptidase i C7M27_02178 ENOG4105DM4 PTS System C7M27_02179 ENOG4105DE4 1-phosphofructokinase C7M27_02180 ENOG4105E98 transcriptional regulator DeoR family C7M27_02181 ENOG4107RBB ABC transporter, permease C7M27_02182 ENOG4105C19 ABC transporter C7M27_02183 ENOG4107X8C Efflux transporter RND family MFP subunit C7M27_02185 ENOG4105BZ1 (ABC) transporter C7M27_02186 ENOG4105BZ1 (ABC) transporter C7M27_02187 ENOG41067WU Molybdopterin converting factor (Subunit 1) C7M27_02188 ENOG4108ZAF Molybdopterin C7M27_02189 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein C7M27_02190 ENOG4105CVM Molybdenum cofactor synthesis domain protein C7M27_02191 ENOG4105D06 uba thif-type nad fad binding protein C7M27_02192 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) C7M27_02195 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C7M27_02196 ENOG4105D3R alkyl hydroperoxide reductase C7M27_02197 ENOG4105D8X mechanosensitive ion channel C7M27_02199 ENOG4105CH2 amidohydrolase C7M27_02201 ENOG4105NQC Flavodoxin C7M27_02207 ENOG4108XRC Protein of unknown function (DUF458) C7M27_02208 ENOG4107IN1 Protein of unknown function (DUF1797) C7M27_02209 ENOG4105EPM Diguanylate phosphodiesterase C7M27_02210 ENOG4105K6S Short-chain dehydrogenase reductase Sdr C7M27_02212 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein C7M27_02214 ENOG4105UIN C7M27_02215 ENOG4107R88 Chemotaxis protein (CheV) C7M27_02217 ENOG4105CHM Aminotransferase C7M27_02218 ENOG4105BZU Histidine kinase C7M27_02220 ENOG4105K4I Scp-like extracellular C7M27_02221 ENOG4105F9V Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid C7M27_02222 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C7M27_02223 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer C7M27_02226 ENOG4105F6S Spore photoproduct lyase C7M27_02228 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) C7M27_02229 ENOG4105KRI phosphocarrier protein (HPr C7M27_02231 ENOG4105CID antiterminator C7M27_02235 ENOG4105DC7 peptidase M24 C7M27_02236 ENOG4105C59 p-type ATPase C7M27_02239 ENOG4105F0V Cell wall hydrolase C7M27_02245 ENOG4105FEA Spore maturation protein C7M27_02246 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr C7M27_02248 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) C7M27_02249 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) C7M27_02250 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase C7M27_02251 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) C7M27_02252 ENOG4108K88 Membrane C7M27_02254 ENOG4105E14 MotA TolQ exbB proton channel C7M27_02255 ENOG4105ER2 Ompa motb domain protein C7M27_02256 ENOG41090MY MarR family Transcriptional regulator C7M27_02257 ENOG4105BZU Histidine kinase C7M27_02261 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) C7M27_02262 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) C7M27_02263 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) C7M27_02264 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit C7M27_02266 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase C7M27_02267 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) C7M27_02268 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) C7M27_02270 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C7M27_02271 ENOG4105BZU Histidine kinase C7M27_02272 ENOG4108TGC Acyltransferase C7M27_02276 ENOG4105D0M Protease HtpX homolog C7M27_02278 ENOG410681C small acid-soluble spore protein C7M27_02280 ENOG4108WZW RNA polymerase sigma C7M27_02281 ENOG4107TS3 membrane protein, TerC C7M27_02282 ENOG4107T5V SNARE associated Golgi C7M27_02283 ENOG4105BZU Histidine kinase C7M27_02284 ENOG4105FDF Could be involved in DNA repair (By similarity) C7M27_02285 ENOG4105DQE DNA ligase C7M27_02294 ENOG4105V75 Transcriptional regulator C7M27_02295 ENOG4105CJW magnesium transporter C7M27_02298 ENOG4106849 propeptide, pepSY amd peptidase M4 C7M27_02300 ENOG41062D9 Histidine kinase C7M27_02301 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C7M27_02302 ENOG4108X43 YKOF domain protein C7M27_02303 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein C7M27_02304 ENOG4108JJB ABC transporter C7M27_02305 ENOG4108W7F transporter, permease C7M27_02307 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C7M27_02308 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) C7M27_02309 ENOG4107Y2X deaminase C7M27_02310 ENOG4108ZHJ Organic hydroperoxide resistance protein C7M27_02311 ENOG4105K56 Transcriptional regulator C7M27_02314 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) C7M27_02315 ENOG4105CIY formyltetrahydrofolate deformylase C7M27_02316 ENOG41080TC multidrug resistance protein C7M27_02318 ENOG4108428 Inherit from COG: -acetyltransferase C7M27_02322 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) C7M27_02323 ENOG4108S4H thioesterase Superfamily protein C7M27_02324 ENOG4107TUM Amidinotransferase C7M27_02325 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) C7M27_02326 ENOG4108JQ7 (ABC) transporter C7M27_02327 ENOG4107SN7 NLP P60 protein C7M27_02328 ENOG4105DTQ mandelate racemase muconate lactonizing C7M27_02329 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A C7M27_02332 ENOG4105C3U ABC transporter C7M27_02333 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C7M27_02334 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C7M27_02335 ENOG4108ME1 Peptidase M55 D-aminopeptidase C7M27_02337 ENOG4105C0H protease C7M27_02339 ENOG4105CKK Glycosyl transferase, family 2 C7M27_02340 ENOG4105EDW glycosyl transferase, family 39 C7M27_02342 ENOG4107R7I amino acid C7M27_02343 ENOG4107GRR phosphate transport regulator C7M27_02344 ENOG4105CJ3 phosphate transporter C7M27_02347 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase C7M27_02352 ENOG41068G1 C7M27_02354 ENOG410906S phage-like element pbsx protein xkdt C7M27_02355 ENOG41066EA baseplate J family protein C7M27_02356 ENOG4105MFU Protein of unknown function (DUF2634) C7M27_02358 ENOG4105X7F C7M27_02359 ENOG4108WZM domain protein C7M27_02360 ENOG4108FKH Transglycosylase SLT domain C7M27_02361 ENOG4105MTC XkdN-like protein C7M27_02362 ENOG4105FR7 XkdM protein, phage-like element PBSX C7M27_02363 ENOG4105PQS phage protein C7M27_02365 ENOG41060SN C7M27_02370 ENOG4108MDF Phage Portal Protein C7M27_02371 ENOG4105IG6 Phage terminase, large subunit C7M27_02372 ENOG4108TFU terminase (Small subunit) C7M27_02381 ENOG410635T phage-like element pbsx protein C7M27_02382 ENOG4105WEF catalase C7M27_02383 ENOG4105K7W phage-related replication protein C7M27_02384 ENOG4105KWG Pfam:DUF1696 C7M27_02385 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase C7M27_02386 ENOG41068K0 YCII-related domain C7M27_02389 ENOG4105JD4 ATPase yjob C7M27_02391 ENOG4107TSN permease C7M27_02392 ENOG4105CTX dehydratase C7M27_02393 ENOG4107QZW Altronate oxidoreductase C7M27_02394 ENOG4107KJX Transcriptional regulator C7M27_02395 ENOG4108I5G Major Facilitator superfamily C7M27_02396 ENOG4105DMW Dehydrogenase reductase C7M27_02397 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) C7M27_02398 ENOG4105CPQ Dehydrogenase C7M27_02399 ENOG4105DG4 malate L-lactate dehydrogenase C7M27_02400 ENOG4105CT4 transporter C7M27_02401 ENOG4105D2H Uronic isomerase C7M27_02404 ENOG4105Q95 Cupin 2, conserved barrel domain protein C7M27_02406 ENOG4108IXI (ABC) transporter C7M27_02407 ENOG4105C4B ABC transporter, permease C7M27_02408 ENOG4105EXQ uroporphyrinogen iii synthase hem4 C7M27_02410 ENOG41087PP glycosyltransferase MGT family C7M27_02411 ENOG4106A3M Cytochrome p-450 C7M27_02416 ENOG4108IEG Formate dehydrogenase Alpha subunit C7M27_02421 ENOG4107CUJ Protein of unknown function (DUF2690) C7M27_02422 ENOG4108ZJ4 polysaccharide deacetylase C7M27_02424 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) C7M27_02427 ENOG4108Z66 YbaK ebsC protein C7M27_02429 ENOG4105VMI -acetyltransferase C7M27_02430 ENOG4105G7B Protein of unknown function (DUF2992) C7M27_02431 ENOG4105DG6 mannose-6-phosphate isomerase C7M27_02432 ENOG4105DM4 PTS System C7M27_02435 ENOG4108PSK reductase C7M27_02442 ENOG4106BHF C7M27_02448 ENOG4106BHF C7M27_02450 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase C7M27_02473 ENOG4105IG6 Phage terminase, large subunit C7M27_02503 ENOG410635T phage-like element pbsx protein C7M27_02504 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C7M27_02506 ENOG4105JHY Membrane C7M27_02507 ENOG4105D9U N-acetyltransferase C7M27_02508 ENOG4105C28 cystathionine C7M27_02509 ENOG4105C28 cystathionine C7M27_02511 ENOG4108ZMI UPF0477 protein C7M27_02514 ENOG4105ENA helicase C7M27_02524 ENOG4107A88 C7M27_02525 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH C7M27_02526 ENOG4105DWF phosphomethylpyrimidine kinase C7M27_02527 ENOG4105D06 uba thif-type nad fad binding protein C7M27_02528 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) C7M27_02531 ENOG4108VEU Thiamine monophosphate synthase C7M27_02532 ENOG4105ETU transcriptional activator (TenA C7M27_02535 ENOG4105EMS pseudouridine synthase C7M27_02536 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C7M27_02539 ENOG4105MIX Adenylate cyclase C7M27_02540 ENOG4105E4C Lytic transglycosylase catalytic C7M27_02541 ENOG4108Z18 K06886 hemoglobin C7M27_02542 ENOG4105T58 Dithiol-disulfide isomerase C7M27_02544 ENOG4105DPN Oligoendopeptidase f C7M27_02546 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis C7M27_02547 ENOG4108ZCF integral membrane protein C7M27_02548 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) C7M27_02551 ENOG4108JQ7 (ABC) transporter C7M27_02553 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C7M27_02554 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C7M27_02555 ENOG4108J59 Extracellular solute-binding protein, family 5 C7M27_02556 ENOG4105C31 Tryptophanyl-tRNA synthetase C7M27_02558 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C7M27_02561 ENOG4108JQ7 (ABC) transporter C7M27_02562 ENOG4105C3U ABC transporter C7M27_02564 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C7M27_02565 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C7M27_02568 ENOG4107RMD Basic membrane lipoprotein C7M27_02573 ENOG4105DBV ornithine carbamoyltransferase C7M27_02575 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain C7M27_02576 ENOG4105C8Y Acetylornithine aminotransferase C7M27_02578 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) C7M27_02579 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase C7M27_02581 ENOG4105IQ5 FAD linked oxidase domain protein C7M27_02583 ENOG4105VG1 fes assembly suf system protein C7M27_02584 ENOG4108MXZ Esterase C7M27_02585 ENOG4108KP7 hydrolase C7M27_02587 ENOG41073B9 C7M27_02589 ENOG4107AYK membrAne C7M27_02590 ENOG4105EPR degv family C7M27_02591 ENOG4105D4Y metalloprotease C7M27_02592 ENOG410751J C7M27_02594 ENOG4105K7K Transcriptional regulator C7M27_02598 ENOG4105QNR S1 RNA binding domain protein C7M27_02599 ENOG4108VPT UPF0234 protein C7M27_02601 ENOG4105MA6 gCN5-related N-acetyltransferase C7M27_02602 ENOG4108SZE gCN5-related N-acetyltransferase C7M27_02603 ENOG4107RCC Major Facilitator Superfamily C7M27_02604 ENOG4105DIA mandelate racemase muconate lactonizing C7M27_02606 ENOG41061P3 phosphosulfolactate synthase C7M27_02607 ENOG4108N5B 2-phosphosulfolactate phosphatase C7M27_02608 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) C7M27_02609 ENOG4107RIQ Sulfate adenylate transferase C7M27_02610 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) C7M27_02611 ENOG4107S9D Alpha beta hydrolase C7M27_02612 ENOG4105MYW Pentapeptide repeat protein C7M27_02613 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C7M27_02629 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C7M27_02630 ENOG4108ZUB Lysine exporter protein (Lyse ygga) C7M27_02631 ENOG4105SF0 DinB family C7M27_02632 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) C7M27_02633 ENOG4105ETE Transcriptional regulator (LacI family C7M27_02634 ENOG4106HBX Transcriptional Regulator AraC Family C7M27_02635 ENOG4105UQX Mate efflux family protein C7M27_02638 ENOG4105CAQ asparagine synthetase C7M27_02640 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C7M27_02642 ENOG4105ERH Fumarylacetoacetate hydrolase C7M27_02652 ENOG4105EYH Exonuclease C7M27_02654 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation C7M27_02657 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding C7M27_02658 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) C7M27_02659 ENOG4106K7D Major facilitator family transporter C7M27_02660 ENOG4108KK1 membrane protein AbrB duplication C7M27_02663 ENOG4105TRI Hydrolase C7M27_02668 ENOG4108INS Transcriptional regulator C7M27_02669 ENOG4107SCK Monooxygenase C7M27_02672 ENOG41060YP C7M27_02673 ENOG4106CAD Protein of unknown function (DUF3311) C7M27_02674 ENOG4105E1V na solute symporter C7M27_02675 ENOG4105X3H Excalibur domain protein C7M27_02676 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C7M27_02677 ENOG4105XVF Competence transcription factor C7M27_02681 ENOG4106YBV Methyl-accepting chemotaxis C7M27_02682 ENOG4107ZYJ bioY protein C7M27_02683 ENOG4107F3J Amp-dependent synthetase and ligase C7M27_02685 ENOG4107TB6 phosphoglycerate mutase C7M27_02686 ENOG4108HUF Transporter C7M27_02688 ENOG4105KD7 acetyltransferase C7M27_02690 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 C7M27_02692 ENOG4105CEY Amp-dependent synthetase and ligase C7M27_02694 ENOG4105DF9 Lipoate-protein, ligase C7M27_02695 ENOG4108RQ5 Beta-lactamase domain-containing protein C7M27_02698 ENOG4105DER m42 family C7M27_02699 ENOG41090T1 Membrane C7M27_02701 ENOG4105ECB domain protein C7M27_02703 ENOG4105C1Q protoporphyrinogen oxidase C7M27_02704 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) C7M27_02705 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) C7M27_02706 ENOG4105BZ4 penicillin-binding protein C7M27_02707 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation C7M27_02714 ENOG4105K59 histidine triad (HIT) protein C7M27_02715 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) C7M27_02716 ENOG4105NBU tryptophan transport protein C7M27_02722 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C7M27_02724 ENOG4105EQI Metal Dependent Phosphohydrolase C7M27_02725 ENOG4106D4I domain protein C7M27_02726 ENOG4107VRP DNA repair exonuclease C7M27_02727 ENOG4105RHA ABC transporter, permease C7M27_02728 ENOG4108IUX (ABC) transporter C7M27_02730 ENOG4105CGU Enoyl-CoA hydratase C7M27_02732 ENOG4105NCW Trka-c domain protein C7M27_02733 ENOG4107S91 Sodium hydrogen exchanger C7M27_02734 ENOG4105D4P Coproporphyrinogen iii oxidase C7M27_02736 ENOG4105F1N DNA alkylation repair C7M27_02737 ENOG4105WZB UPF0342 protein C7M27_02738 ENOG4106MP8 UPF0754 membrane protein C7M27_02740 ENOG410839P C7M27_02744 ENOG4105BZ1 (ABC) transporter C7M27_02745 ENOG4105BZ1 (ABC) transporter C7M27_02748 ENOG4105F0I Aminotransferase C7M27_02749 ENOG4107VMI polysaccharide deacetylase C7M27_02750 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) C7M27_02751 ENOG4105D64 Mechanosensitive ion channel C7M27_02753 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C7M27_02754 ENOG4105WMR Protein CrcB homolog C7M27_02756 ENOG4105C37 (CBS) domain C7M27_02757 ENOG4105CHM Aminotransferase C7M27_02759 ENOG4105C37 (CBS) domain C7M27_02760 ENOG4105F6E Acyl-transferase C7M27_02761 ENOG4108FN7 Aldo keto reductase C7M27_02762 ENOG4108AEY RNA polymerase sigma factor C7M27_02763 ENOG4105J37 C7M27_02766 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C7M27_02767 ENOG4105C8J )-transporter C7M27_02768 ENOG4105CUB amino acid C7M27_02769 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C7M27_02770 ENOG4105BZN citrate synthase C7M27_02773 ENOG4105G6Z alkaline phosphatase C7M27_02774 ENOG4105ED1 spovr family C7M27_02781 ENOG4105WH1 Two component transcriptional regulator luxr family C7M27_02782 ENOG4105BZU Histidine kinase C7M27_02784 ENOG4105C6V Glycerol-3-phosphate dehydrogenase C7M27_02785 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) C7M27_02787 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator C7M27_02788 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C7M27_02789 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase C7M27_02790 ENOG4107YBY Hydrolase C7M27_02791 ENOG41080XP Cbs domain C7M27_02793 ENOG4108YBP pseudouridine synthase C7M27_02803 ENOG4105BZU Histidine kinase C7M27_02805 ENOG4105VEQ Cold shock protein C7M27_02806 ENOG4108TU7 Inherit from COG: (ABC) transporter C7M27_02807 ENOG4105CJ1 ABC, transporter C7M27_02808 ENOG4105CZV ABC transporter C7M27_02809 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family C7M27_02812 ENOG4105CS1 NAD(P)H quinone oxidoreductase C7M27_02813 ENOG4105C0R drug resistance transporter emrb qaca subfamily C7M27_02814 ENOG4105CW7 secretion protein, HlyD family C7M27_02815 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes C7M27_02816 ENOG4106AKX UPF0229 protein C7M27_02817 ENOG4105CYN Serine protein kinase C7M27_02821 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) C7M27_02823 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) C7M27_02826 ENOG4105VZ8 Transcriptional regulator C7M27_02827 ENOG4107D63 C7M27_02828 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) C7M27_02830 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) C7M27_02831 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component C7M27_02832 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein C7M27_02833 ENOG4105E2Y ABC, transporter C7M27_02836 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) C7M27_02837 ENOG4105EC3 peptidase S51, dipeptidase E C7M27_02839 ENOG4108N23 SpoOM-related protein C7M27_02861 ENOG4105G5W regulator Fur family C7M27_02862 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C7M27_02864 ENOG4107NBY Membrane C7M27_02865 ENOG4105BZ1 (ABC) transporter C7M27_02866 ENOG4105EVI UPF0374 protein C7M27_02869 ENOG4105CAN Short-chain dehydrogenase reductase Sdr C7M27_02870 ENOG4106BXE C7M27_02871 ENOG4105CEN a g-specific adenine glycosylase C7M27_02872 ENOG41067AE Membrane-bound metal-dependent hydrolase C7M27_02873 ENOG4105EJV Membrane C7M27_02874 ENOG4105CKK Glycosyl transferase, family 2 C7M27_02875 ENOG4105D74 hydrolase C7M27_02876 ENOG4106AKJ C7M27_02880 ENOG4105F27 Major Facilitator C7M27_02884 ENOG4105ECP epimerase C7M27_02887 ENOG4107Y03 Nitroreductase C7M27_02888 ENOG4105JAB phenazine biosynthesis protein, phzf family C7M27_02889 ENOG4108IHU transport system permease protein C7M27_02890 ENOG4105DQ5 transport system permease protein C7M27_02891 ENOG4108MES Periplasmic binding protein C7M27_02893 ENOG410834F Transcriptional regulator C7M27_02894 ENOG4105C0R drug resistance transporter emrb qaca subfamily C7M27_02895 ENOG4108YYS metal-dependent hydrolase (By similarity) C7M27_02896 ENOG4107Y80 Major Facilitator superfamily C7M27_02897 ENOG4105YA8 Transcriptional regulator C7M27_02898 ENOG4105H93 Acyltransferase family C7M27_02899 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold C7M27_02900 ENOG4105U3E Transcriptional regulator C7M27_02901 ENOG4108KYE ABC-2 type transporter C7M27_02902 ENOG41090VJ ABC-2 type transporter C7M27_02903 ENOG4105CJ1 ABC, transporter C7M27_02904 ENOG4105WH1 Two component transcriptional regulator luxr family C7M27_02905 ENOG4105BZU Histidine kinase C7M27_02906 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase C7M27_02908 ENOG4105BZ1 (ABC) transporter C7M27_02909 ENOG4105BZ1 (ABC) transporter C7M27_02911 ENOG4105CI1 PTS System C7M27_02912 ENOG4108Q3X Transcriptional regulator C7M27_02913 ENOG4105F8D glycoside hydrolase family 4 C7M27_02918 ENOG4105KK4 UPF0060 membrane protein C7M27_02919 ENOG41069DP small acid-soluble spore protein C7M27_02920 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family C7M27_02922 ENOG4107QKR Dehydrogenase C7M27_02924 ENOG4107RUY (E1 component), alpha subunit C7M27_02929 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C7M27_02931 ENOG4105D7N magnesium and cobalt transport protein CorA C7M27_02932 ENOG4106KE4 Dehydrogenase C7M27_02936 ENOG4105D8X mechanosensitive ion channel C7M27_02938 ENOG4105UPD Calcium Proton C7M27_02939 ENOG4108ISG Major Facilitator C7M27_02941 ENOG4107U9T Pfam:Ribonuclease_BN C7M27_02943 ENOG4105KJF protein tyrosine phosphatase C7M27_02946 ENOG4107RKG DJ-1/PfpI family C7M27_02947 ENOG4105CGH 5'-nucleotidase C7M27_02948 ENOG4108RCM Nitroreductase C7M27_02949 ENOG4107414 GntR family transcriptional regulator C7M27_02950 ENOG4105CG3 alpha amylase, catalytic region C7M27_02951 ENOG4105C5Y PTS System C7M27_02952 ENOG4105E1K spore germination protein C7M27_02953 ENOG4108Q5U germination protein, ger(x)c family C7M27_02955 ENOG4105GEU Spore germination protein C7M27_02960 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) C7M27_02964 ENOG4108RPX mosc domain containing protein C7M27_02965 ENOG410855V Acylphosphatase C7M27_02970 ENOG4108MRH transcriptional regulatory protein C7M27_02972 ENOG4107QPK )-transporter C7M27_02973 ENOG4108J20 pectate lyase C7M27_02976 ENOG4108HUF Transporter C7M27_02977 ENOG4105DQ5 transport system permease protein C7M27_02978 ENOG4108U1V ABC transporter, permease C7M27_02979 ENOG4105E0A ABC, transporter C7M27_02980 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein C7M27_02982 ENOG4105FDU atp-dependent rna helicase C7M27_02983 ENOG4105C5H ABC transporter C7M27_02987 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C7M27_02988 ENOG4105DXB Major Facilitator superfamily C7M27_02989 ENOG4107SWG transcriptional regulator MERR family C7M27_02991 ENOG4105C5H ABC transporter C7M27_02992 ENOG4105FKZ Methyl-accepting chemotaxis C7M27_02993 ENOG4105C26 Dehydrogenase C7M27_02994 ENOG4105CUB amino acid C7M27_02996 ENOG4105EU0 Major facilitator Superfamily C7M27_02997 ENOG41090R9 glycosyltransferase C7M27_02998 ENOG4107R51 Glycosyl transferase, family 2 C7M27_02999 ENOG41090R9 glycosyltransferase C7M27_03001 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase C7M27_03002 ENOG4105E0M Sulfatase C7M27_03003 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C7M27_03004 ENOG4108R1P C7M27_03005 ENOG41061H0 Monooxygenase C7M27_03006 ENOG41082F9 transcriptional regulator C7M27_03007 ENOG4108PCN EamA-like transporter family C7M27_03008 ENOG4107QQG Dehydrogenase C7M27_03009 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) C7M27_03011 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) C7M27_03012 ENOG4105DG4 malate L-lactate dehydrogenase C7M27_03013 ENOG4108KB0 deacetylase C7M27_03018 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase C7M27_03019 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) C7M27_03020 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) C7M27_03021 ENOG4105DK0 Indole-3-glycerol phosphate synthase C7M27_03022 ENOG4108I0Q anthranilate phosphoribosyltransferase C7M27_03023 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C7M27_03024 ENOG4106I4J membrane C7M27_03028 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily C7M27_03029 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) C7M27_03030 ENOG4105H67 Protein of unknown function (DUF421) C7M27_03031 ENOG4105F8D glycoside hydrolase family 4 C7M27_03032 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component C7M27_03034 ENOG4105E0S extracellular solute-binding protein family 1 C7M27_03035 ENOG4105EKC C7M27_03037 ENOG4107TDE lipolytic protein G-D-S-L family C7M27_03038 ENOG4105CX8 fg-gap repeat protein C7M27_03039 ENOG4105CX8 fg-gap repeat protein C7M27_03042 ENOG4107TDE lipolytic protein G-D-S-L family C7M27_03043 ENOG41075H3 AraC family transcriptional regulator C7M27_03044 ENOG4105F5H Glycosyl Hydrolase Family 88 C7M27_03045 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component C7M27_03046 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component C7M27_03047 ENOG410769Z extracellular solute-binding protein family 1 C7M27_03048 ENOG4105EQD regulatoR C7M27_03049 ENOG4105C2F Histidine kinase C7M27_03052 ENOG4105M18 -acetyltransferase C7M27_03053 ENOG4105WEF catalase C7M27_03056 ENOG4107S9F NmrA family C7M27_03057 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein C7M27_03058 ENOG4105M4P Tetr family transcriptional regulator C7M27_03060 ENOG4105CDY transcriptional regulatory protein C7M27_03064 ENOG4108HFV C7M27_03070 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C7M27_03071 ENOG4105CBD Diacylglycerol kinase C7M27_03073 ENOG4108IG5 Transcriptional regulator C7M27_03074 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C7M27_03075 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C7M27_03076 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C7M27_03077 ENOG4105CK7 Sodium proline symporter C7M27_03078 ENOG4105KT7 mgtC SapB transporter C7M27_03079 ENOG4105CRN Aminoglycoside phosphotransferase C7M27_03081 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) C7M27_03082 ENOG4105C4R Atp-dependent dna helicase C7M27_03083 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) C7M27_03085 ENOG4105CBC glutamate synthase C7M27_03086 ENOG4105KGF protein, YerC YecD C7M27_03087 ENOG4108R5T secreted protein C7M27_03090 ENOG4105DVH amino acid C7M27_03092 ENOG4105C12 Phosphoribosylglycinamide synthetase C7M27_03093 ENOG4105DC1 bifunctional purine biosynthesis protein purh C7M27_03094 ENOG4108V3E phosphoribosylglycinamide formyltransferase C7M27_03095 ENOG4105CXB phosphoribosylaminoimidazole synthetase C7M27_03097 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii C7M27_03098 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I C7M27_03099 ENOG4105VR9 phosphoribosylformylglycinamidine synthase C7M27_03100 ENOG4105C8V SAICAR synthetase C7M27_03101 ENOG4105C83 adenylosuccinate lyase C7M27_03102 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit C7M27_03103 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) C7M27_03108 ENOG4105C7N Xanthine uracil vitamin C permease C7M27_03114 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C7M27_03116 ENOG4105C85 amino acid C7M27_03117 ENOG4107STQ Multicopper oxidase C7M27_03119 ENOG4107YUH hydrolase C7M27_03125 ENOG4107QNK )-transporter C7M27_03126 ENOG4108ZMR Ion transport 2 domain-containing protein C7M27_03128 ENOG4108WV1 Pfam:DUF477 C7M27_03129 ENOG4105DQX Zinc finger domain C7M27_03130 ENOG41087YS Phage shock protein A C7M27_03132 ENOG4105CT4 transporter C7M27_03133 ENOG4105CPQ Dehydrogenase C7M27_03134 ENOG4105PGZ NB-ARC domain C7M27_03136 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) C7M27_03138 ENOG4108TYN CAAX amino terminal protease family protein C7M27_03140 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) C7M27_03141 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) C7M27_03142 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) C7M27_03143 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C7M27_03144 ENOG4105C5H ABC transporter C7M27_03145 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C7M27_03146 ENOG410801F ribosomal-protein-alanine acetyltransferase C7M27_03147 ENOG41072GX Peptidase M22 Glycoprotease C7M27_03148 ENOG4105K8N protein family UPF0079, ATPase C7M27_03149 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) C7M27_03158 ENOG4105D3P Mannan endo-1,4-beta-mannosidase C7M27_03159 ENOG4105DG6 mannose-6-phosphate isomerase C7M27_03160 ENOG4105EVU fructokinase C7M27_03161 ENOG4108TZY GntR Family Transcriptional Regulator C7M27_03162 ENOG4105CS2 ec 3.2.1.21 C7M27_03163 ENOG4105CK1 PTS System C7M27_03164 ENOG4105VCP PTS System C7M27_03165 ENOG4105VZJ PTS System C7M27_03166 ENOG4105F27 Major Facilitator C7M27_03167 ENOG41090UD (LipO)protein C7M27_03168 ENOG4107TVP HD domain protein C7M27_03169 ENOG4108YM7 Gcn5-related n-acetyltransferase C7M27_03171 ENOG4108ZMX Domain of unknown function (DU1801) C7M27_03172 ENOG4105G6Z alkaline phosphatase C7M27_03175 ENOG4105VRS hydrolase family 18 C7M27_03176 ENOG4105DRR Transcriptional regulator, GntR family C7M27_03178 ENOG4105C2C drug resistance transporter, Bcr CflA C7M27_03179 ENOG4105FS7 Transcriptional regulator C7M27_03180 ENOG4108TVJ Nitroreductase C7M27_03181 ENOG4105EYF MMPL domain protein C7M27_03182 ENOG41062A4 Transcriptional regulator C7M27_03184 ENOG4105C85 amino acid C7M27_03186 ENOG4105WQG acetyltransferase C7M27_03188 ENOG4105PF9 Transcriptional regulator C7M27_03192 ENOG4108QY0 Membrane C7M27_03193 ENOG410900G Protein of unknown function (DUF421) C7M27_03197 ENOG4105XXY Thioredoxin C7M27_03198 ENOG4108VGI doxx family C7M27_03199 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase C7M27_03200 ENOG4108TVJ Nitroreductase C7M27_03201 ENOG41076HS cation diffusion facilitator family transporter C7M27_03202 ENOG4108Z5V transcriptional regulator, merr family C7M27_03203 ENOG4108UQV Membrane C7M27_03204 ENOG4108WC5 Alpha Beta Hydrolase Fold protein C7M27_03205 ENOG4105EYF MMPL domain protein C7M27_03206 ENOG4108VB1 regulatoR C7M27_03207 ENOG4105ENE Histidine kinase C7M27_03209 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) C7M27_03210 ENOG4108ZHR arsR family transcriptional regulator C7M27_03211 ENOG4108SQ9 flavin reductase domain protein, FMN-binding C7M27_03213 ENOG4107Y9U Membrane C7M27_03214 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C7M27_03215 ENOG4105US7 Histidine kinase C7M27_03219 ENOG4105Z7P Acetyltransferase (GNAT) family C7M27_03220 ENOG4107R5R arsenical pump membrane protein C7M27_03221 ENOG41082YX Transcriptional regulator, arsr family C7M27_03223 ENOG4107Z6X Transcriptional regulator C7M27_03224 ENOG4105MJ9 esterase C7M27_03225 ENOG4108ZMQ domain protein C7M27_03226 ENOG4108ZMQ domain protein C7M27_03227 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C7M27_03228 ENOG4105T38 integral membrane protein C7M27_03229 ENOG4105GIG C7M27_03230 ENOG4105CZ9 Domain of unknown function (DU1801) C7M27_03232 ENOG4105DXI Major Facilitator superfamily C7M27_03233 ENOG4107U9B transcriptional regulator C7M27_03234 ENOG41086D8 Transcriptional regulator C7M27_03235 ENOG4108UZ3 Transporter C7M27_03236 ENOG4108MCI Transcriptional regulator, ARAC family C7M27_03238 ENOG4108VJ1 Transcriptional regulator (CarD family C7M27_03239 ENOG4105VEQ Cold shock protein C7M27_03240 ENOG4108V4B ThiJ pfpI C7M27_03245 ENOG4106BHF C7M27_03247 ENOG4106ANW SMI1_KNR4 C7M27_03248 ENOG4108HH4 Major Facilitator Superfamily C7M27_03249 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein C7M27_03250 ENOG4108W2Y isochorismatase C7M27_03253 ENOG4105DEN Luciferase family C7M27_03263 ENOG4105RV9 Transcriptional regulator C7M27_03264 ENOG4105M5P UPF0310 protein C7M27_03268 ENOG41064BQ Phosphatase C7M27_03270 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) C7M27_03271 ENOG4105WN5 stage II sporulation protein C7M27_03272 ENOG4107SGM protein serine threonine phosphatase C7M27_03273 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase C7M27_03274 ENOG4105FUA antagonist C7M27_03275 ENOG4107MMM Anti-sigma-factor antagonist C7M27_03276 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) C7M27_03278 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C7M27_03279 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein C7M27_03280 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) C7M27_03282 ENOG4105CKV Membrane C7M27_03283 ENOG410905X membrane-flanked domain protein C7M27_03284 ENOG4105C1J atp-dependent rna helicase C7M27_03285 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) C7M27_03286 ENOG4105CPF Cell wall formation (By similarity) C7M27_03287 ENOG4105SZ6 Thioredoxin C7M27_03291 ENOG4105FDT acyl-CoA dehydrogenase C7M27_03294 ENOG4105CJ1 ABC, transporter C7M27_03295 ENOG4106F5Q Membrane C7M27_03296 ENOG4107QJT sodium dicarboxylate symporter C7M27_03297 ENOG4108MRH transcriptional regulatory protein C7M27_03298 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism C7M27_03299 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit C7M27_03302 ENOG41082W1 Cupin 2, conserved barrel domain protein C7M27_03303 ENOG4105QVS general stress protein C7M27_03304 ENOG4105EU9 C7M27_03305 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) C7M27_03307 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) C7M27_03311 ENOG4105C0X amino acid C7M27_03313 ENOG4107R8N Glycosyl transferase, family 2 C7M27_03314 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) C7M27_03317 ENOG4105C9U ATP-dependent DNA helicase RecQ C7M27_03319 ENOG4105VCH membrane C7M27_03321 ENOG410606W general stress protein C7M27_03324 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C7M27_03325 ENOG4105HMZ Methyltransferase C7M27_03327 ENOG4105ETD TRANSCRIPTIONal C7M27_03328 ENOG4107QM2 Aldo Keto reductase C7M27_03329 ENOG4107RVG penicillin-binding protein C7M27_03330 ENOG41061CK Antibiotic biosynthesis monooxygenase C7M27_03332 ENOG4105XJB lipolytic protein G-D-S-L family C7M27_03333 ENOG4107258 Transcriptional regulator C7M27_03335 ENOG4105P4J Allophanate hydrolase, subunit 1 C7M27_03336 ENOG4105CFM UPF0317 protein C7M27_03337 ENOG4105C5A transporter C7M27_03338 ENOG4105E7W lamb ycsf family protein C7M27_03343 ENOG4108ZX0 Signal peptidase I C7M27_03345 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C7M27_03350 ENOG4108ZYE Transcriptional regulator C7M27_03351 ENOG4108T5E Copper resistance protein C7M27_03352 ENOG4105KTB nuclear export factor GLE1 C7M27_03353 ENOG4105H9W Short-chain dehydrogenase reductase Sdr C7M27_03355 ENOG4105C26 Dehydrogenase C7M27_03356 ENOG4108JPW Aminotransferase C7M27_03358 ENOG4105YVS arsR family transcriptional regulator C7M27_03359 ENOG41067V3 Antibiotic biosynthesis monooxygenase C7M27_03360 ENOG4108DBC nitroreductase C7M27_03361 ENOG4105R8C Transcriptional regulator C7M27_03364 ENOG4108IPW abc transporter atp-binding protein C7M27_03365 ENOG4105CM4 permease protein C7M27_03366 ENOG4105DHS permease protein C7M27_03367 ENOG4105CFH Aspartokinase C7M27_03371 ENOG4105BZU Histidine kinase C7M27_03372 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C7M27_03373 ENOG4107WD8 ABC transporter, permease C7M27_03377 ENOG4105E1K spore germination protein C7M27_03380 ENOG4105DUX Transporter C7M27_03382 ENOG41069ZX C7M27_03383 ENOG41069ZX C7M27_03384 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) C7M27_03385 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase C7M27_03386 ENOG4106P55 Transcriptional regulator C7M27_03388 ENOG4105DRP amino acid AbC transporter C7M27_03389 ENOG4105CDA abc transporter atp-binding protein C7M27_03391 ENOG4105W8Z 4'-phosphopantetheinyl transferase C7M27_03393 ENOG4105SX7 Transporter C7M27_03399 ENOG4105CEY Amp-dependent synthetase and ligase C7M27_03400 ENOG4105KVH Transcriptional regulator C7M27_03401 ENOG4108VA3 3-hexulose-6-phosphate synthase C7M27_03402 ENOG41080HJ 6-phospho 3-hexuloisomerase C7M27_03403 ENOG4105C8Q Methyl-accepting chemotaxis C7M27_03406 ENOG4105CS2 ec 3.2.1.21 C7M27_03407 ENOG4108VEN abc transporter atp-binding protein C7M27_03409 ENOG4105K56 Transcriptional regulator C7M27_03411 ENOG4105HHM rdd domain containing protein C7M27_03413 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein C7M27_03414 ENOG4105E5Q amino acid AbC transporter C7M27_03415 ENOG4105CKI cobalamin synthesis protein C7M27_03416 ENOG4105S7A ErfK ybiS ycfS ynhG family protein C7M27_03420 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) C7M27_03421 ENOG4108IFG nitrite reductase, (NAD(P)H) C7M27_03422 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit C7M27_03423 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C7M27_03425 ENOG4105U6C Alpha beta hydrolase fold protein C7M27_03426 ENOG4108PJD permease C7M27_03431 ENOG4107YHD transcriptional regulator C7M27_03432 ENOG4105CK7 Sodium proline symporter C7M27_03433 ENOG4105C26 Dehydrogenase C7M27_03435 ENOG410756H nucleotidyltransferase C7M27_03436 ENOG4105I82 acetyl xylan esterase C7M27_03437 ENOG4105C5Q Transcriptional regulator C7M27_03438 ENOG41089UC methyltransferase, type 11 C7M27_03439 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) C7M27_03440 ENOG4105I1F Resistance protein C7M27_03441 ENOG4107RA1 nh(3)-dependent nad( ) synthetase C7M27_03442 ENOG4105EIG urea carboxylase-associated protein 1 C7M27_03449 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C7M27_03455 ENOG4107SQ8 Glycine betaine C7M27_03456 ENOG4108IJ7 Glycine betaine C7M27_03457 ENOG4108A65 Transcriptional regulator C7M27_03458 ENOG4107XZQ multidrug resistance protein C7M27_03459 ENOG41079KZ Major Facilitator Superfamily C7M27_03461 ENOG4108TTB tellurium resistance protein C7M27_03462 ENOG4107TS3 membrane protein, TerC C7M27_03463 ENOG4106FN3 tellurium resistance protein C7M27_03464 ENOG4106FN3 tellurium resistance protein C7M27_03465 ENOG4108N0M stress protein C7M27_03466 ENOG4105DEN Luciferase family C7M27_03468 ENOG4105DIK (ABC) transporter C7M27_03469 ENOG4105DSE periplasmic solute binding protein C7M27_03471 ENOG4105H9W Short-chain dehydrogenase reductase Sdr C7M27_03477 ENOG4107SET aldo keto reductase C7M27_03478 ENOG4108SDH ABC, transporter C7M27_03479 ENOG4108IUW ABC transporter C7M27_03480 ENOG4107Y7X LytTR C7M27_03482 ENOG41060AI SEC-C motif C7M27_03484 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold C7M27_03485 ENOG4107RB3 L-asparaginase C7M27_03486 ENOG4105J7D transcriptional regulator C7M27_03487 ENOG4105C0R drug resistance transporter emrb qaca subfamily C7M27_03488 ENOG4107EPV Aminotransferase class V C7M27_03489 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) C7M27_03490 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) C7M27_03491 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) C7M27_03492 ENOG4105DGI Alkaline phosphatase C7M27_03493 ENOG4105MUA Resistance protein C7M27_03499 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C7M27_03500 ENOG4106UX7 integral membrane protein C7M27_03503 ENOG4105CTX dehydratase C7M27_03504 ENOG41073TP transcriptional regulator C7M27_03505 ENOG4105EQX glucarate dehydratase C7M27_03506 ENOG4105DJB Major Facilitator Superfamily C7M27_03507 ENOG4105C26 Dehydrogenase C7M27_03508 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase C7M27_03511 ENOG4105CSV Glutaminase C7M27_03514 ENOG4108J5H Homocysteine s-methyltransferase C7M27_03515 ENOG4108IQI permease C7M27_03516 ENOG4105CM2 brancheD-chain amino acid aminotransferase C7M27_03519 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) C7M27_03520 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane C7M27_03522 ENOG4105C72 UPF0176 protein C7M27_03525 ENOG4107ZTW SNARE associated Golgi C7M27_03526 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase C7M27_03527 ENOG4108WC5 Alpha Beta Hydrolase Fold protein C7M27_03529 ENOG4108TCS Glutamyl endopeptidase C7M27_03530 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR C7M27_03531 ENOG4106AXJ AraC family transcriptional regulator C7M27_03532 ENOG410631K Membrane C7M27_03534 ENOG4105DCM major facilitator superfamily C7M27_03535 ENOG410645S MarR family Transcriptional regulator C7M27_03537 ENOG4105CXY transporter C7M27_03538 ENOG4107VXM glycerophosphoryl diester phosphodiesterase C7M27_03539 ENOG4107QTZ amino acid C7M27_03541 ENOG4107E6A Cytochrome p-450 C7M27_03542 ENOG4108HWY Beta-lactamase C7M27_03544 ENOG4106DDH Sporulation-specific SASP protein C7M27_03546 ENOG4106K80 C7M27_03548 ENOG4105G0J serine threonine protein kinase C7M27_03551 ENOG4108RWP Major Facilitator Superfamily protein C7M27_03552 ENOG4108RWP Major Facilitator Superfamily protein C7M27_03553 ENOG4105WAB arsR family transcriptional regulator C7M27_03554 ENOG4105GPN Uncharacterized conserved protein (DUF2294) C7M27_03559 ENOG4108TWJ NADH dehydrogenase subunit 5 C7M27_03560 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C7M27_03562 ENOG4105D03 DNA-3-methyladenine glycosylase II C7M27_03563 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) C7M27_03564 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) C7M27_03565 ENOG4107U5W ybbr family C7M27_03566 ENOG4105C8B TIGR00159 family C7M27_03568 ENOG4105EMN RNA polymerase sigma factor C7M27_03574 ENOG4105EWC Purine nucleoside phosphorylase C7M27_03576 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate C7M27_03580 ENOG4105D17 glycoside hydrolase, family 3 domain protein C7M27_03581 ENOG4105EHZ conserved protein UCP016719 C7M27_03582 ENOG410874W AraC family transcriptional regulator C7M27_03586 ENOG4108SA1 esterase C7M27_03589 ENOG4105CHH sulfate transporter C7M27_03605 ENOG4108NMV polysaccharide deacetylase C7M27_03608 ENOG4105D1F ATP-binding protein C7M27_03611 ENOG4108I0C methyltransferase C7M27_03612 ENOG4108UJD 30S ribosomal protein S9 C7M27_03613 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) C7M27_03614 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) C7M27_03615 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) C7M27_03616 ENOG4108JJB ABC transporter C7M27_03617 ENOG4108JJB ABC transporter C7M27_03618 ENOG4108ZT0 50S ribosomal protein l17 C7M27_03619 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C7M27_03620 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) C7M27_03621 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits C7M27_03622 ENOG41067V7 50S ribosomal protein L36 C7M27_03624 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) C7M27_03626 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) C7M27_03627 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) C7M27_03629 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) C7M27_03630 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) C7M27_03631 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) C7M27_03632 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) C7M27_03634 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits C7M27_03636 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) C7M27_03637 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal C7M27_03639 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) C7M27_03640 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) C7M27_03643 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity C7M27_03645 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) C7M27_03646 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) C7M27_03647 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) C7M27_03648 ENOG4107SKW Inherit from COG: Alpha beta hydrolase C7M27_03649 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) C7M27_03650 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) C7M27_03651 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) C7M27_03652 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) C7M27_03653 ENOG4105XPM ribosomal protein C7M27_03654 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C7M27_03655 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C7M27_03656 ENOG4107Y49 methyltransferase C7M27_03658 ENOG4108VZM 50s ribosomal protein L10 C7M27_03661 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) C7M27_03664 ENOG4105M0M Tetracycline resistance protein C7M27_03665 ENOG4105C2N RNA methyltransferase TrmH family group 3 C7M27_03666 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) C7M27_03667 ENOG4105C8N cysteinyl-tRNA synthetase C7M27_03668 ENOG4105D7W serine acetyltransferase C7M27_03669 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) C7M27_03670 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) C7M27_03671 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) C7M27_03672 ENOG4105CTP PilT protein domain protein C7M27_03673 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) C7M27_03674 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) C7M27_03676 ENOG41066A3 ATP guanido phosphotransferase C7M27_03677 ENOG4108Z0C Uvrb UvrC protein C7M27_03694 ENOG4105CRK lysyL-tRNA synthetase C7M27_03695 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) C7M27_03697 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase C7M27_03698 ENOG4105KRF dihydroneopterin aldolase C7M27_03699 ENOG4105EEI dihydropteroate synthase C7M27_03700 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 C7M27_03701 ENOG4105DDQ anthranilate synthase C7M27_03702 ENOG4105CRQ synthase (Component I) C7M27_03703 ENOG4105C6T cysteine synthase C7M27_03704 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase C7M27_03705 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) C7M27_03707 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C7M27_03708 ENOG4108UGV hypoxanthine phosphoribosyltransferase C7M27_03709 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) C7M27_03715 ENOG41060GV RNA binding s1 domain protein C7M27_03718 ENOG4105VYY sporulation protein yabp C7M27_03719 ENOG41082I2 s4 domain protein C7M27_03720 ENOG4108IY2 MazG family C7M27_03722 ENOG4108M14 stage v sporulation protein t C7M27_03723 ENOG4108JA2 transcriptioN-repair coupling factor C7M27_03725 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) C7M27_03726 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) C7M27_03727 ENOG4105C5T Phosphoribosyl pyrophosphate synthase C7M27_03728 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) C7M27_03729 ENOG4105K4W Could be involved in septation (By similarity) C7M27_03730 ENOG4105KME endoribonuclease L-psp C7M27_03731 ENOG4105DFT pur operon repressor C7M27_03732 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) C7M27_03733 ENOG4105XEW small acid-soluble spore protein C7M27_03734 ENOG4105W42 Veg protein C7M27_03735 ENOG4105XFA sporulation peptidase YabG C7M27_03736 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) C7M27_03738 ENOG41069ER domain protein C7M27_03739 ENOG4105F8V Hydrolase, tatD family C7M27_03740 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) C7M27_03741 ENOG4105KRN Transcriptional regulator, abrb family C7M27_03742 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) C7M27_03743 ENOG4105VC4 domain protein C7M27_03744 ENOG41060K3 Methyltransferase C7M27_03745 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) C7M27_03746 ENOG4105MA4 psp1 domain protein C7M27_03747 ENOG4105FA2 dna polymerase iii C7M27_03748 ENOG4105XVJ Protein of unknown function (DUF327) C7M27_03749 ENOG4105X0R protein from nitrogen regulatory protein P-II C7M27_03750 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) C7M27_03751 ENOG4105CXN decarboxylase C7M27_03752 ENOG4105CDW Resistance protein C7M27_03760 ENOG41067KS pro-sigma K processing C7M27_03762 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) C7M27_03763 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) C7M27_03764 ENOG4105C6E dna polymerase iii C7M27_03765 ENOG4108Z6B deaminase C7M27_03766 ENOG4105GTG Isochorismatase C7M27_03767 ENOG4105VRS hydrolase family 18 C7M27_03769 ENOG4105ZMH deoxynucleoside kinase C7M27_03771 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) C7M27_03772 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) C7M27_03773 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) C7M27_03775 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C7M27_03782 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C7M27_03783 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C7M27_03786 ENOG410848D S4 domain protein YaaA C7M27_03787 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) C7M27_03788 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) C7M27_03789 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) C7M27_03792 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) C7M27_03793 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) C7M27_03794 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) C7M27_03797 ENOG4107QJE Chromosome Partitioning Protein C7M27_03798 ENOG4105FA0 parb-like partition protein C7M27_03799 ENOG4108ZDA Sporulation protein YyaC C7M27_03801 ENOG4105VDK protein, conserved in bacteria C7M27_03802 ENOG4108J2R molybdopterin oxidoreductase C7M27_03803 ENOG4105C3G gtp-binding protein C7M27_03804 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) C7M27_03805 ENOG4108UUM single-stranded DNA-binding protein C7M27_03806 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) C7M27_03807 ENOG4105CGK Exodeoxyribonuclease III C7M27_03809 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase C7M27_03810 ENOG4108UW5 maltose o-acetyltransferase C7M27_03812 ENOG4107FCW Abortive infection protein C7M27_03813 ENOG4105C7Z Conserved Protein C7M27_03814 ENOG4108J8C transporter major facilitator family protein C7M27_03815 ENOG4105NAE bifunctional deaminase-reductase domain protein C7M27_03816 ENOG4105UNS Pfam:DUF419 C7M27_03817 ENOG4108U7W acetyltransferase C7M27_03819 ENOG41082BV acetyltransferase C7M27_03820 ENOG4108U05 Transcriptional regulator C7M27_03822 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein C7M27_03824 ENOG41090E6 transcriptional regulator MERR family C7M27_03828 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase C7M27_03829 ENOG4105KVH Transcriptional regulator C7M27_03832 ENOG4108XMW Membrane C7M27_03833 ENOG4105BZR domain protein C7M27_03834 ENOG4105K9Q Binds to the 23S rRNA (By similarity) C7M27_03835 ENOG4105EDW glycosyl transferase, family 39 C7M27_03836 ENOG4105DJ2 Major Facilitator Superfamily C7M27_03840 ENOG4105CDU Replicative dna helicase C7M27_03841 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase C7M27_03842 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis C7M27_03847 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C7M27_03848 ENOG4105BZU Histidine kinase C7M27_03851 ENOG4105Q2H domain protein C7M27_03852 ENOG4105C0H protease C7M27_03853 ENOG4108JUB Transcriptional regulator C7M27_03854 ENOG4105C8Y Acetylornithine aminotransferase C7M27_03855 ENOG4108IQI permease C7M27_03856 ENOG41066UZ arginase EC 3.5.3.1 C7M27_03858 ENOG410780I phosphoprotein phosphatase activity C7M27_03859 ENOG4105WQG acetyltransferase C7M27_03860 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) C7M27_03864 ENOG4105E2A Dehydrogenase C7M27_03867 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) C7M27_03870 ENOG4107RRE RNA-directed DNA polymerase C7M27_03877 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 C7M27_03879 ENOG4108S3Y transcriptional regulator C7M27_03881 ENOG4105CS2 ec 3.2.1.21 C7M27_03882 ENOG4108JU3 Alkyl hydroperoxide reductase C7M27_03883 ENOG4105D3R alkyl hydroperoxide reductase C7M27_03884 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) C7M27_03885 ENOG4105C6Z Gluconate C7M27_03886 ENOG4105CMG Carbohydrate kinase C7M27_03887 ENOG4105G3Z GntR family transcriptional regulator C7M27_03888 ENOG4105BZW Glycerate kinase C7M27_03890 ENOG41067MG lrgb family C7M27_03892 ENOG41061AU MarR family Transcriptional regulator C7M27_03893 ENOG4107JEE Short-chain dehydrogenase reductase Sdr C7M27_03894 ENOG4105J7D transcriptional regulator C7M27_03897 ENOG41085PJ rdd domain containing protein C7M27_03899 ENOG4108ITS PQQ enzyme repeat C7M27_03900 ENOG41085PJ rdd domain containing protein C7M27_03901 ENOG4105C26 Dehydrogenase C7M27_03902 ENOG4105ST3 Transcriptional regulator C7M27_03903 ENOG41061TZ Short-chain dehydrogenase reductase Sdr C7M27_03905 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) C7M27_03906 ENOG4107QNK )-transporter C7M27_03909 ENOG4105CPC Aldo Keto reductase C7M27_03911 ENOG4105C26 Dehydrogenase C7M27_03913 ENOG4105D7K pfkb domain protein C7M27_03914 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) C7M27_03915 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) C7M27_03917 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) C7M27_03918 ENOG4105F0H myo-inositol catabolism protein C7M27_03919 ENOG4107TRN Xylose isomerase domain protein TIM barrel C7M27_03920 ENOG4105D2N Aldolase C7M27_03926 ENOG4108V5C ABC transporter C7M27_03932 ENOG410667J hydrolase C7M27_03933 ENOG4107QHE Choloylglycine hydrolase C7M27_03936 ENOG4105EAB amino acid AbC transporter C7M27_03937 ENOG4108HW4 amino acid AbC transporter C7M27_03940 ENOG4108PGP mmge prpd family protein C7M27_03941 ENOG4105ENY Ethanolamine utilization protein eutH C7M27_03942 ENOG4108TM9 integral membrane protein C7M27_03943 ENOG4107RHR regulatoR C7M27_03945 ENOG4105D9N nucleoside C7M27_03946 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) C7M27_03948 ENOG4107W25 arginase agmatinase formiminoglutamase C7M27_03949 ENOG4105CI2 imidazolone-5-propionate hydrolase C7M27_03950 ENOG4105CGP Urocanate hydratase C7M27_03951 ENOG4105C84 Histidine ammonia-lyase C7M27_03953 ENOG4106Z5D Glycoside Hydrolase Family 43 C7M27_03954 ENOG4105M6F mutator MutT protein C7M27_03956 ENOG4108F3G Type I restriction-modification system, R subunit C7M27_03959 ENOG4107EV6 Inherit from COG: YD repeat protein C7M27_03961 ENOG4105C5Y PTS System C7M27_03962 ENOG4105CS2 ec 3.2.1.21 C7M27_03963 ENOG4107YZX Universal stress protein C7M27_03965 ENOG4105CNA YD repeat protein C7M27_03969 ENOG4107TDE lipolytic protein G-D-S-L family C7M27_03970 ENOG4105C1J atp-dependent rna helicase C7M27_03971 ENOG4105DEU major facilitator superfamily C7M27_03973 ENOG4105CID antiterminator C7M27_03974 ENOG4108RZ2 Glycoside hydrolase family 16 C7M27_03975 ENOG4105D4T Citrate transporter C7M27_03976 ENOG4105CH6 catalase C7M27_03980 ENOG4105DHI Methyltransferase C7M27_03981 ENOG4105CY2 Citrate transporter C7M27_03982 ENOG4105D6N CoA-transferase, subunit a C7M27_03983 ENOG4108IIH CoA-transferase subunit B C7M27_03984 ENOG4105DTD Dehydrogenase C7M27_03989 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) C7M27_03990 ENOG4105WH1 Two component transcriptional regulator luxr family C7M27_03991 ENOG4105BZU Histidine kinase C7M27_03993 ENOG4105CMR udp-glucose 4-epimerase C7M27_03995 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) C7M27_04002 ENOG4107BJW polysaccharide deacetylase C7M27_04005 ENOG4105D2K citrate carrier protein C7M27_04006 ENOG4105C4M (Ubiquinol oxidase) subunit I C7M27_04007 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C7M27_04008 ENOG4108JJ9 ABC, transporter C7M27_04009 ENOG4108JJ8 (ABC) transporter C7M27_04010 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) C7M27_04011 ENOG4105ETS cytosine purines uracil thiamine allantoin C7M27_04015 ENOG41069JR C7M27_04016 ENOG4105DA5 (ABC) transporter C7M27_04019 ENOG4105CH6 catalase C7M27_04020 ENOG4108VX5 3-methyladenine DNA glycosylase C7M27_04022 ENOG4105EMD TRANSCRIPTIONal C7M27_04023 ENOG4105VZJ PTS System C7M27_04024 ENOG4105CK1 PTS System C7M27_04025 ENOG4105VCP PTS System C7M27_04026 ENOG4105F8D glycoside hydrolase family 4 C7M27_04027 ENOG4105CM2 brancheD-chain amino acid aminotransferase C7M27_04028 ENOG4108VHC Short-chain dehydrogenase reductase Sdr C7M27_04029 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD C7M27_04031 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein C7M27_04032 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) C7M27_04033 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase C7M27_04038 ENOG4105IIU Aminopeptidase C7M27_04039 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C7M27_04040 ENOG4105GVJ transcriptional regulator C7M27_04042 ENOG4105X1N Glycosyl transferase family 8 C7M27_04045 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin C7M27_04046 ENOG4105CK1 PTS System C7M27_04047 ENOG4108YV3 Protein of unknown function (DUF2711) C7M27_04049 ENOG4105DR4 Methyltransferase C7M27_04051 ENOG4105D8G Major Facilitator superfamily C7M27_04052 ENOG41067MG lrgb family C7M27_04053 ENOG4105VAW lrga family C7M27_04054 ENOG4105CMU LysR family (Transcriptional regulator C7M27_04056 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) C7M27_04057 ENOG4107SJW iron permease, FTR1 C7M27_04058 ENOG410650H (LipO)protein C7M27_04059 ENOG4105DBE peroxidase C7M27_04060 ENOG4107ZXU DSBA oxidoreductase C7M27_04065 ENOG4105WH5 Teichoic acid glycosylation protein C7M27_04066 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) C7M27_04068 ENOG4107BMA Transglycosylase associated protein C7M27_04069 ENOG4105E2S oxidase) subunit II C7M27_04070 ENOG4105BZ9 Cytochrome C oxidase, subunit I C7M27_04071 ENOG4105CCU oxidase (Subunit III) C7M27_04072 ENOG41060D1 Quinol oxidase C7M27_04075 ENOG4108DBC nitroreductase C7M27_04076 ENOG4105DEN Luciferase family C7M27_04077 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin C7M27_04080 ENOG4108QTI )-transporter C7M27_04081 ENOG4105C5Y PTS System C7M27_04084 ENOG4105DWF phosphomethylpyrimidine kinase C7M27_04088 ENOG4108RJ9 Glycosyl transferase, family 2 C7M27_04089 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) C7M27_04090 ENOG4105C26 Dehydrogenase C7M27_04097 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C7M27_04098 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD C7M27_04100 ENOG4107TY6 Acylneuraminate cytidylyltransferase C7M27_04101 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG C7M27_04102 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) C7M27_04103 ENOG4105C1B dTDP-glucose 4-6-dehydratase C7M27_04104 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase C7M27_04105 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase C7M27_04107 ENOG4105D82 Glutamate dehydrogenase C7M27_04108 ENOG4105C26 Dehydrogenase C7M27_04111 ENOG4105FCW Major Facilitator superfamily C7M27_04112 ENOG41061WN bacilysin biosynthesis protein C7M27_04113 ENOG4106CHD Bacilysin biosynthesis protein bacB C7M27_04114 ENOG4105CHR reductase C7M27_04115 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase C7M27_04117 ENOG4105CHM Aminotransferase C7M27_04120 ENOG4108IJ2 phosphate acetyltransferase C7M27_04121 ENOG4105DUM transcriptional regulator, lysR family C7M27_04122 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) C7M27_04123 ENOG4108RNG Permease of the drug metabolite transporter C7M27_04124 ENOG4108VCI transcription factor, rsfa family C7M27_04126 ENOG4105DCI Phosphohydrolase C7M27_04128 ENOG41062ES Transcriptional regulator C7M27_04129 ENOG4105C57 major facilitator superfamily C7M27_04131 ENOG4105C22 threonyL-tRNA synthetase C7M27_04132 ENOG41067TZ transcriptional regulator, MarR family C7M27_04133 ENOG41069HH 4-oxalocrotonate tautomerase C7M27_04134 ENOG4108Z4T Peptidase M50 C7M27_04135 ENOG4108XFG YwhD family C7M27_04137 ENOG4105BZ4 penicillin-binding protein C7M27_04138 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) C7M27_04139 ENOG4105CYW agmatinase C7M27_04141 ENOG4108RDQ ABC transporter C7M27_04147 ENOG4107JM4 Tetratricopeptide repeat C7M27_04156 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E C7M27_04158 ENOG410684U Domain of unknown function (DUF1934) C7M27_04159 ENOG4105C75 arginyL-tRNA synthetase C7M27_04161 ENOG4107V6Q Cyclic nucleotide-binding domain C7M27_04165 ENOG4108IUE nitrate reductase beta subunit C7M27_04166 ENOG4105R3A Nitrate reductase C7M27_04168 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C7M27_04169 ENOG4105BZ1 (ABC) transporter C7M27_04170 ENOG4105NAE bifunctional deaminase-reductase domain protein C7M27_04172 ENOG4105E5J UV damage endonuclease C7M27_04174 ENOG4105DF6 Fe-S oxidoreductase C7M27_04175 ENOG4105C1G acyl-Coa dehydrogenase C7M27_04177 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) C7M27_04179 ENOG410812K response regulator receiver protein C7M27_04180 ENOG4105D2N Aldolase C7M27_04181 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway C7M27_04182 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C7M27_04183 ENOG4105CBT Fructose-1,6-bisphosphatase C7M27_04184 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) C7M27_04186 ENOG4107104 thymidine kinase C7M27_04187 ENOG4105C6K Malic enzyme C7M27_04188 ENOG4107TT2 Auxin Efflux Carrier C7M27_04190 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase C7M27_04191 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) C7M27_04192 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) C7M27_04195 ENOG4108ZXQ stage ii sporulation protein r C7M27_04197 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C7M27_04198 ENOG410815N Probably functions as a manganese efflux pump (By similarity) C7M27_04199 ENOG4107WAU Protein tyrosine phosphatase C7M27_04200 ENOG4108YZG isomerase C7M27_04201 ENOG4108UIC UPF0340 protein C7M27_04202 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) C7M27_04203 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) C7M27_04205 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) C7M27_04209 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) C7M27_04210 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) C7M27_04211 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) C7M27_04212 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) C7M27_04214 ENOG4106778 Protein of unknown function (DUF1146) C7M27_04216 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C7M27_04217 ENOG4105JFG SpoIID LytB domain protein C7M27_04219 ENOG4108TF4 von Willebrand factor, type A C7M27_04221 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) C7M27_04227 ENOG4108YZ9 Urea amidohydrolase subunit gamma C7M27_04228 ENOG4105KI2 Urea amidohydrolase subunit beta C7M27_04229 ENOG4105CQM Urea amidohydrolase subunit alpha C7M27_04230 ENOG4108Z40 Transcriptional regulator C7M27_04231 ENOG4108RYK Nad-dependent epimerase dehydratase C7M27_04232 ENOG4106BRK C7M27_04233 ENOG4107TXC Transcriptional regulator C7M27_04234 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C7M27_04238 ENOG4107TCE N-acetyltransferase C7M27_04239 ENOG4105FRN stage II sporulation protein C7M27_04241 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase C7M27_04243 ENOG4105BZU Histidine kinase C7M27_04244 ENOG4107P26 C7M27_04245 ENOG4105D3W isochorismatase C7M27_04246 ENOG41080V3 Major Facilitator superfamily C7M27_04247 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease C7M27_04248 ENOG4108M26 parallel beta-helix repeat protein C7M27_04249 ENOG4105CZM Major Facilitator C7M27_04250 ENOG4107MII Sugar-specific transcriptional regulator TrmB C7M27_04251 ENOG4105MT0 Sporulation transcriptional regulator spoiiid C7M27_04252 ENOG4105DFF Rod shape-determining protein mreb C7M27_04254 ENOG4105CGA flagellar basal-body rod protein FlgG C7M27_04256 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) C7M27_04257 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) C7M27_04259 ENOG4108VAC response regulator C7M27_04264 ENOG4105Z8H single-stranded DNA-binding protein C7M27_04265 ENOG4105E98 transcriptional regulator DeoR family C7M27_04266 ENOG410667J hydrolase C7M27_04267 ENOG4105C0D helicase C7M27_04268 ENOG4105KBK Zinc finger, swim domain protein C7M27_04270 ENOG4105HTX biosynthesis protein C7M27_04271 ENOG4107YJ4 chain length determinant protein C7M27_04272 ENOG4108RB3 Capsular polysaccharide biosynthesis protein C7M27_04273 ENOG4105C6Y Udp-glucose 6-dehydrogenase C7M27_04274 ENOG4108XI2 Domain of unknown function (DUF1963) C7M27_04279 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) C7M27_04280 ENOG4105FGV Chromate C7M27_04281 ENOG4105CAH Chromate C7M27_04283 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C7M27_04285 ENOG4107XC4 flavin reductase domain protein, FMN-binding C7M27_04289 ENOG4107QJE Chromosome Partitioning Protein C7M27_04295 ENOG4105K4H Nlp p60 protein C7M27_04305 ENOG4105EE0 oxidoreductase C7M27_04306 ENOG41080HJ 6-phospho 3-hexuloisomerase C7M27_04307 ENOG4108VA3 3-hexulose-6-phosphate synthase C7M27_04308 ENOG4105KVH Transcriptional regulator C7M27_04310 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase C7M27_04317 ENOG4105E2A Dehydrogenase