locus-tag class description C7M28_00002 ENOG4105K7W phage-related replication protein C7M28_00003 ENOG4108X3M OsmC Ohr family protein C7M28_00004 ENOG410814C multidrug resistance protein C7M28_00008 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) C7M28_00009 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) C7M28_00012 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) C7M28_00013 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C7M28_00014 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C7M28_00015 ENOG4105U6W MutT NUDIX family protein C7M28_00016 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C7M28_00017 ENOG4106F1P AAA ATPase, central domain protein C7M28_00018 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) C7M28_00019 ENOG4105CXI aluminum resistance protein C7M28_00020 ENOG4105KV4 Transcriptional regulator C7M28_00021 ENOG4105C5F glutamine synthetase C7M28_00022 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C7M28_00026 ENOG4108ZUE Phage regulatory protein rha C7M28_00060 ENOG4108FKH Transglycosylase SLT domain C7M28_00062 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj C7M28_00069 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase C7M28_00070 ENOG4106ANW SMI1_KNR4 C7M28_00071 ENOG4106BHF C7M28_00072 ENOG410780I phosphoprotein phosphatase activity C7M28_00076 ENOG41079P0 C7M28_00080 ENOG4107AUC C7M28_00085 ENOG4107NTZ C7M28_00089 ENOG410907G C7M28_00090 ENOG4105CT4 transporter C7M28_00091 ENOG4105DSG hydrolase family 43 C7M28_00092 ENOG4105E2R ROK family C7M28_00093 ENOG4105C93 Xylose Isomerase C7M28_00094 ENOG4105CMG Carbohydrate kinase C7M28_00095 ENOG4107Y9E nuclease C7M28_00096 ENOG4105C54 Major Facilitator superfamily C7M28_00097 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C7M28_00099 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) C7M28_00115 ENOG4108NHD germination protein C7M28_00118 ENOG4105FVX C7M28_00120 ENOG4105K7W phage-related replication protein C7M28_00122 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) C7M28_00123 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) C7M28_00125 ENOG4108SVB resolvase C7M28_00126 ENOG4105VPS UPF0291 protein C7M28_00127 ENOG4105CV1 Transketolase (EC 2.2.1.1) C7M28_00131 ENOG4107QIV Cytochrome c biogenesis protein C7M28_00136 ENOG4107DZX Small, acid-soluble spore protein P C7M28_00138 ENOG4108I0Z Aconitate hydratase C7M28_00139 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C7M28_00142 ENOG41067CD Small, acid-soluble spore protein Tlp C7M28_00144 ENOG4105MI2 C7M28_00145 ENOG4105W8X HesB YadR YfhF-family protein C7M28_00146 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) C7M28_00147 ENOG4105K4P CoA-binding domain protein C7M28_00148 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C7M28_00153 ENOG4107QWR cellulase (EC 3.2.1.4) C7M28_00155 ENOG4108MYR Secreted protein C7M28_00156 ENOG4107SYN Glycosyl hydrolases family 43 C7M28_00158 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C7M28_00159 ENOG4107T5V SNARE associated Golgi C7M28_00161 ENOG4107QX3 carboxylase C7M28_00162 ENOG4105E39 Enoyl-CoA hydratase C7M28_00163 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase C7M28_00164 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit C7M28_00165 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C7M28_00166 ENOG4105CEY Amp-dependent synthetase and ligase C7M28_00167 ENOG4105C1G acyl-Coa dehydrogenase C7M28_00168 ENOG4105F32 YngK protein C7M28_00169 ENOG4106U2H Protein of unknown function (DUF1360) C7M28_00171 ENOG4105CEY Amp-dependent synthetase and ligase C7M28_00172 ENOG4105C0W non-ribosomal peptide synthetase C7M28_00174 ENOG4105C0W non-ribosomal peptide synthetase C7M28_00175 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family C7M28_00176 ENOG4108N2V aldose 1-epimerase C7M28_00177 ENOG4107QJQ Mate efflux family protein C7M28_00182 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C7M28_00183 ENOG4105SKE transcriptional Regulator LysR family C7M28_00184 ENOG4105CB2 alcohol dehydrogenase C7M28_00185 ENOG4105BZ8 glutamate synthase C7M28_00186 ENOG4105CBC glutamate synthase C7M28_00187 ENOG4105C5Q Transcriptional regulator C7M28_00188 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) C7M28_00189 ENOG4105II7 pyrroline-5-carboxylate reductase C7M28_00193 ENOG4108UB7 C7M28_00194 ENOG41068WN C7M28_00197 ENOG4105CJ1 ABC, transporter C7M28_00199 ENOG4105IE8 Alpha-ketoglutarate permease C7M28_00200 ENOG4107U6E carbohydrate kinase FGGY C7M28_00201 ENOG4108M3J Dehydrogenase C7M28_00202 ENOG4108M3J Dehydrogenase C7M28_00203 ENOG4108J2R molybdopterin oxidoreductase C7M28_00205 ENOG4107QNK )-transporter C7M28_00206 ENOG4105CIB oxidoreductase Domain protein C7M28_00207 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) C7M28_00208 ENOG4105ETE Transcriptional regulator (LacI family C7M28_00212 ENOG4105EC8 Methyl-accepting chemotaxis C7M28_00214 ENOG4108YQE rare lipoprotein a C7M28_00215 ENOG4105XPP Protein of unknown function (DUF1275) C7M28_00216 ENOG4108NR7 pectate lyase C7M28_00217 ENOG4108RAV Conserved protein C7M28_00219 ENOG4105F0F Oxalate decarboxylase C7M28_00223 ENOG41073R8 VanW family C7M28_00225 ENOG4105VMP Transcriptional regulator C7M28_00226 ENOG4105NX3 Membrane C7M28_00228 ENOG4108Q5Y Membrane C7M28_00230 ENOG4108V4B ThiJ pfpI C7M28_00231 ENOG4108J4B Beta-lactamase C7M28_00234 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) C7M28_00235 ENOG4107T94 Endo-14-beta-xylanase C7M28_00242 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) C7M28_00244 ENOG4106ANW SMI1_KNR4 C7M28_00245 ENOG4106BHF C7M28_00249 ENOG4108Z7R Chaperone CsaA C7M28_00250 ENOG4105FTV AraC Family Transcriptional Regulator C7M28_00251 ENOG4108HJF gCN5-related N-acetyltransferase C7M28_00253 ENOG4108W8B Beta-lactamase domain protein C7M28_00255 ENOG4105D29 Helix-turn-helix type 11 domain protein C7M28_00257 ENOG4105KTU Transcriptional regulator, arsr family C7M28_00259 ENOG4108SJC Membrane C7M28_00263 ENOG4105ECK Fatty Acid Desaturase C7M28_00264 ENOG4108ZGX Histidine kinase C7M28_00265 ENOG4108S01 response regulator C7M28_00266 ENOG41069ER domain protein C7M28_00267 ENOG4105C9U ATP-dependent DNA helicase RecQ C7M28_00268 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C7M28_00269 ENOG4105SCY DNAK suppressor C7M28_00277 ENOG4105C26 Dehydrogenase C7M28_00278 ENOG4105EWU Squalene--hopene cyclase C7M28_00279 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C7M28_00280 ENOG4105C8J )-transporter C7M28_00281 ENOG4105C09 Bile acid C7M28_00282 ENOG4105C7S Dehydrogenase C7M28_00284 ENOG4107T89 von Willebrand factor, type A C7M28_00285 ENOG4105GMT ATPase associated with various cellular activities aaa_5 C7M28_00287 ENOG4105K4H Nlp p60 protein C7M28_00288 ENOG41087PP glycosyltransferase MGT family C7M28_00291 ENOG4107QMU Mate efflux family protein C7M28_00292 ENOG4106SCS STAS domain C7M28_00296 ENOG4105FR1 rard protein C7M28_00299 ENOG4105C6Z Gluconate C7M28_00300 ENOG41090U3 tautomerase C7M28_00303 ENOG4105FBA Phospholipase Carboxylesterase C7M28_00306 ENOG4105E1V na solute symporter C7M28_00310 ENOG4108VXD carboxy-peptidase C7M28_00311 ENOG4105D3A purine nucleoside phosphorylase DeoD-type C7M28_00313 ENOG4106Z5R C7M28_00314 ENOG410841Q phosphoesterase PA-phosphatase related protein C7M28_00320 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein C7M28_00321 ENOG4108TSC N-acetyltransferase C7M28_00322 ENOG4107S4Y M20 DapE family protein YgeY C7M28_00325 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C7M28_00332 ENOG4107T32 3-phytase (EC 3.1.3.8) C7M28_00333 ENOG4105C5E polysaccharide biosynthesis protein C7M28_00334 ENOG4105E0X reductase C7M28_00335 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) C7M28_00339 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) C7M28_00340 ENOG41090WU lipolytic protein G-D-S-L family C7M28_00341 ENOG4108KF3 Electron transport protein SCO1 SenC C7M28_00343 ENOG4105C7B Threonine dehydratase C7M28_00345 ENOG4108UT2 hemolysin iii C7M28_00347 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) C7M28_00348 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) C7M28_00351 ENOG4107YX5 Pfam:DUF548 C7M28_00352 ENOG4108Y6J UPF0403 protein C7M28_00353 ENOG4105C01 Dihydroxy-acid dehydratase C7M28_00356 ENOG4108V06 Glutathione peroxidase C7M28_00357 ENOG4105CVG Homoserine O-transsuccinylase C7M28_00365 ENOG41081VK Ribonuclease C7M28_00370 ENOG410890F Dynamin family C7M28_00373 ENOG41065KQ synthase C7M28_00374 ENOG4105C2W permease C7M28_00375 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) C7M28_00376 ENOG4105CTD carboxy-peptidase C7M28_00377 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) C7M28_00378 ENOG4108UHU Aldolase C7M28_00379 ENOG4105D7K pfkb domain protein C7M28_00380 ENOG4108M60 Transcriptional regulator C7M28_00382 ENOG4105CHR reductase C7M28_00383 ENOG4105DVT helicase C7M28_00385 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) C7M28_00387 ENOG4108UKS UPF0398 protein C7M28_00388 ENOG4107X2U Inherit from COG: Exonuclease-like protein C7M28_00389 ENOG4108I5C dEAD DEAH box helicase C7M28_00399 ENOG4105BZ4 penicillin-binding protein C7M28_00401 ENOG4105CSM endonuclease III C7M28_00403 ENOG4105C5S asparaginyl-tRNA synthetase C7M28_00404 ENOG4105CHM Aminotransferase C7M28_00406 ENOG4105YAC C7M28_00407 ENOG4105DVT helicase C7M28_00408 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) C7M28_00409 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) C7M28_00410 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) C7M28_00411 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase C7M28_00412 ENOG4105DJ0 Poly(A) Polymerase C7M28_00413 ENOG4105CPK Glycosyl transferase (Group 1 C7M28_00414 ENOG4105FJR Lmbe family C7M28_00415 ENOG4108Z5K methylglyoxal synthase C7M28_00416 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) C7M28_00417 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase C7M28_00418 ENOG4108JYZ YitT family C7M28_00422 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) C7M28_00426 ENOG41068YB TPR repeat-containing protein C7M28_00427 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase C7M28_00429 ENOG4105CIH Imidazole acetol-phosphate transaminase C7M28_00431 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) C7M28_00432 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase C7M28_00434 ENOG4108I0Q anthranilate phosphoribosyltransferase C7M28_00435 ENOG4105CRQ synthase (Component I) C7M28_00436 ENOG4105KHN chorismate mutase C7M28_00437 ENOG4105D49 3-dehydroquinate synthase C7M28_00438 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase C7M28_00439 ENOG4105BZU Histidine kinase C7M28_00440 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) C7M28_00441 ENOG4105EAH synthase C7M28_00442 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) C7M28_00443 ENOG4105XXQ heptaprenyl diphosphate synthase component I C7M28_00445 ENOG4105EUJ GTP cyclohydrolase i C7M28_00446 ENOG4105K70 DNA-binding protein C7M28_00447 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) C7M28_00450 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase C7M28_00451 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) C7M28_00452 ENOG41065D1 C7M28_00453 ENOG4105S2F C7M28_00456 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) C7M28_00457 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) C7M28_00458 ENOG4105CAT Cytidine monophosphate kinase C7M28_00461 ENOG4105MSI germination protein ypeb C7M28_00463 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) C7M28_00464 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase C7M28_00467 ENOG4107RGJ metallophosphoesterase C7M28_00470 ENOG4105I7S Abortive infection protein C7M28_00471 ENOG4105C9U ATP-dependent DNA helicase RecQ C7M28_00472 ENOG4105T7X C7M28_00474 ENOG4108SAX Membrane C7M28_00475 ENOG4108JQ1 Dehydrogenase C7M28_00476 ENOG4105FF2 Type I DHQase C7M28_00479 ENOG4105BZU Histidine kinase C7M28_00480 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C7M28_00481 ENOG4105CRE cytochrome C C7M28_00482 ENOG4107TWT Cytochrome c biogenesis protein C7M28_00484 ENOG4105FE9 pseudouridine synthase C7M28_00486 ENOG4108JIC nucleoside recognition domain protein C7M28_00487 ENOG4105DZ1 carboxypeptidase C7M28_00489 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) C7M28_00490 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) C7M28_00493 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) C7M28_00494 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) C7M28_00495 ENOG4108R6K riboflavin synthase, subunit alpha C7M28_00496 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) C7M28_00498 ENOG4105C3F Signal peptidase i C7M28_00499 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) C7M28_00504 ENOG4107ZE5 PPIases accelerate the folding of proteins C7M28_00509 ENOG4107ZE5 PPIases accelerate the folding of proteins C7M28_00510 ENOG4105PTM secreted protein C7M28_00511 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) C7M28_00513 ENOG4105G6R Stage v sporulation protein ae C7M28_00515 ENOG4105CZ3 stage V sporulation protein ad C7M28_00516 ENOG41090VF Stage v sporulation protein ac C7M28_00519 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C7M28_00520 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) C7M28_00521 ENOG41082AN stage II sporulation protein C7M28_00522 ENOG4105DZ1 carboxypeptidase C7M28_00523 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) C7M28_00524 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) C7M28_00525 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C7M28_00527 ENOG4105I3K Ferric uptake regulator, Fur family C7M28_00528 ENOG4105MZ9 stage II sporulation protein m C7M28_00531 ENOG4105DFD Na H antiporter C7M28_00532 ENOG4108IJ0 Aspartate ammonia-lyase C7M28_00533 ENOG4105HDK L-asparaginase C7M28_00534 ENOG4108IMY Transcriptional regulator C7M28_00536 ENOG4108YZ4 nudix hydrolase C7M28_00538 ENOG4105CPC Aldo Keto reductase C7M28_00542 ENOG4106HZJ C7M28_00543 ENOG4105RHY Pfam:UPF0157 C7M28_00544 ENOG4105KAC Antibiotic biosynthesis monooxygenase C7M28_00545 ENOG4108XET gCN5-related N-acetyltransferase C7M28_00547 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C7M28_00549 ENOG4105E5W Transporter C7M28_00551 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase C7M28_00554 ENOG4108IXY short-chain dehydrogenase reductase C7M28_00555 ENOG41069FQ Metallo-beta-lactamase superfamily C7M28_00556 ENOG4105II7 pyrroline-5-carboxylate reductase C7M28_00558 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C7M28_00560 ENOG410861F 50S ribosomal protein L33 C7M28_00561 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) C7M28_00562 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase C7M28_00563 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) C7M28_00564 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) C7M28_00566 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) C7M28_00567 ENOG4108NA0 Uncharacterized conserved protein (COG2071) C7M28_00568 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) C7M28_00569 ENOG4108HNZ carboxyl transferase C7M28_00570 ENOG4108ZVT methylmalonyl-coA epimerase C7M28_00572 ENOG4108VZI ErfK ybiS ycfS ynhG family protein C7M28_00573 ENOG4108QEG Membrane C7M28_00574 ENOG4105CDA abc transporter atp-binding protein C7M28_00575 ENOG4105E5Q amino acid AbC transporter C7M28_00576 ENOG4108HW3 (ABC) transporter C7M28_00577 ENOG4108Y6J UPF0403 protein C7M28_00578 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) C7M28_00581 ENOG4105C7S Dehydrogenase C7M28_00582 ENOG4105CPP Dehydrogenase, E1 component C7M28_00585 ENOG4105CKM Branched-chain carboxylic acid kinase C7M28_00586 ENOG4107RDP Dehydrogenase C7M28_00588 ENOG4108JUB Transcriptional regulator C7M28_00589 ENOG4106CCJ Protein of unknown function (DUF2627) C7M28_00590 ENOG4105CR4 methylisocitrate lyase C7M28_00591 ENOG4105DXD 2-methylcitrate dehydratase C7M28_00593 ENOG4105C1G acyl-Coa dehydrogenase C7M28_00594 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase C7M28_00596 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C7M28_00597 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C7M28_00599 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase C7M28_00601 ENOG4107QQR Sporulation C7M28_00602 ENOG4105S1Z Stage IV sporulation protein B C7M28_00603 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) C7M28_00604 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) C7M28_00605 ENOG4105DX0 Hemolysin A C7M28_00607 ENOG4105CTB Polyprenyl synthetase C7M28_00608 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C7M28_00609 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) C7M28_00610 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) C7M28_00611 ENOG4105M7K Involved in the transcription termination process (By similarity) C7M28_00612 ENOG4108ZSR alkaline shock protein C7M28_00613 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase C7M28_00617 ENOG410644B Stage III sporulation protein af C7M28_00619 ENOG4105KQ4 Stage iii sporulation protein ad C7M28_00620 ENOG4108CQH stage III sporulation protein AC C7M28_00621 ENOG4105KR5 Stage iii sporulation protein C7M28_00622 ENOG4105CD2 stage iii sporulation protein aa C7M28_00624 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) C7M28_00625 ENOG4105DC7 peptidase M24 C7M28_00626 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) C7M28_00628 ENOG4105CBJ Metal-dependent enzyme C7M28_00631 ENOG4105KST dependent repressor C7M28_00632 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) C7M28_00633 ENOG4105WZW rhodanese family C7M28_00634 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor C7M28_00635 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor C7M28_00636 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) C7M28_00637 ENOG4105C0D helicase C7M28_00640 ENOG4108IMY Transcriptional regulator C7M28_00642 ENOG4105VFR signal peptidase C7M28_00653 ENOG41080XP Cbs domain C7M28_00655 ENOG4105C37 (CBS) domain C7M28_00660 ENOG4105C5X domain protein C7M28_00665 ENOG4105E0M Sulfatase C7M28_00668 ENOG4107ZXI Rhomboid family C7M28_00670 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase C7M28_00675 ENOG41068DG YceG-like family C7M28_00676 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C7M28_00677 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) C7M28_00678 ENOG4105E2Z phosphate ABC transporter (Permease C7M28_00679 ENOG4105C8U phosphate abc transporter C7M28_00680 ENOG4105CVA phosphate C7M28_00681 ENOG4107RF6 penicillin-binding protein C7M28_00683 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) C7M28_00684 ENOG4105SXS Protein of unknown function (DUF456) C7M28_00687 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) C7M28_00688 ENOG41063Y9 C7M28_00689 ENOG4108U5J '-nucleotidase C7M28_00690 ENOG4105N80 Ferric uptake regulator, Fur family C7M28_00691 ENOG4108JYZ YitT family C7M28_00692 ENOG41069ZM Protein of unknown function (DUF2624) C7M28_00693 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) C7M28_00696 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) C7M28_00697 ENOG4105EGD dinuclear metal center protein, YbgI family C7M28_00700 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C7M28_00701 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) C7M28_00702 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 C7M28_00703 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) C7M28_00705 ENOG4105C38 Glycyl-tRNA synthetase beta subunit C7M28_00706 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit C7M28_00707 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) C7M28_00709 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) C7M28_00710 ENOG4105KG3 cytidine deaminase C7M28_00711 ENOG4107YR5 Diacylglycerol kinase C7M28_00712 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) C7M28_00713 ENOG4105CTJ Metal Dependent Phosphohydrolase C7M28_00715 ENOG4105C9A Phoh family C7M28_00716 ENOG4105EI1 sporulation protein yqfd C7M28_00717 ENOG41068P3 sporulation protein YqfC C7M28_00719 ENOG4105DI5 UPF0365 protein C7M28_00720 ENOG4105F7J membrane-bound serine protease C7M28_00721 ENOG4105KTH gatB Yqey C7M28_00724 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C7M28_00725 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) C7M28_00726 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) C7M28_00728 ENOG4105CFG Acts as a chaperone (By similarity) C7M28_00729 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ C7M28_00730 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) C7M28_00731 ENOG4105CSA Coproporphyrinogen iii oxidase C7M28_00732 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) C7M28_00734 ENOG4108ZRV stage ii sporulation protein p C7M28_00735 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) C7M28_00736 ENOG41082YS Binds directly to 16S ribosomal RNA C7M28_00737 ENOG4105TQK DNA polymerase iii, delta' subunit C7M28_00739 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 C7M28_00740 ENOG4108UK2 deaminase C7M28_00741 ENOG4105KQC Competence protein C7M28_00743 ENOG4108D32 Methyltransferase C7M28_00745 ENOG4108WF2 Metal Dependent Phosphohydrolase C7M28_00746 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) C7M28_00747 ENOG410812S Rna-binding protein C7M28_00748 ENOG4105E2X shikimate dehydrogenase C7M28_00749 ENOG4105CQW ribosome biogenesis GTPase YqeH C7M28_00750 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase C7M28_00753 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase C7M28_00754 ENOG41080BT SNARE associated Golgi C7M28_00757 ENOG4105WFK nuclease C7M28_00758 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C7M28_00761 ENOG4105D3P Mannan endo-1,4-beta-mannosidase C7M28_00762 ENOG41087NI Sulfite exporter TauE/SafE C7M28_00763 ENOG4105VFE sira family C7M28_00764 ENOG4107TPS domain protein C7M28_00765 ENOG4105VFE sira family C7M28_00766 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase C7M28_00767 ENOG4105XTG Pfam:DUF156 C7M28_00768 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein C7M28_00769 ENOG41090E6 transcriptional regulator MERR family C7M28_00772 ENOG4105C37 (CBS) domain C7M28_00775 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family C7M28_00776 ENOG4105H3G oxidoreductase C7M28_00777 ENOG4105PGM cation diffusion facilitator family transporter C7M28_00778 ENOG41090U3 tautomerase C7M28_00781 ENOG4105KMT branched-chain amino acid C7M28_00782 ENOG4108UMN azlc family C7M28_00783 ENOG4108ZRZ Transcriptional regulator (AsnC family) C7M28_00784 ENOG41067XF inhibitor C7M28_00786 ENOG41064BW Protein of unknown function (DUF2568) C7M28_00788 ENOG41075D4 Aminoglycoside 6-adenylyltransferase C7M28_00789 ENOG4105EA8 2-Nitropropane dioxygenase C7M28_00790 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) C7M28_00793 ENOG4108MEK Metal-binding protein YodA C7M28_00794 ENOG410904A RNA polymerase C7M28_00795 ENOG4105CPC Aldo Keto reductase C7M28_00797 ENOG4108KAM Transcriptional regulator C7M28_00798 ENOG4105C7F AcnD-accessory protein PrpF C7M28_00800 ENOG41083Q9 chitosanase C7M28_00801 ENOG4105X5K response regulator receiver protein C7M28_00802 ENOG4108VQT Alpha beta hydrolase fold protein C7M28_00803 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein C7M28_00804 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein C7M28_00805 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase C7M28_00807 ENOG4105PGS Spore coat protein C7M28_00808 ENOG4105E2A Dehydrogenase C7M28_00811 ENOG4105VUF Transcriptional regulator C7M28_00813 ENOG4105DQ4 alcohol dehydrogenase C7M28_00814 ENOG4108Z0Z intracellular protease Pfpi family C7M28_00815 ENOG4108HKT sucrose-6-phosphate hydrolase C7M28_00816 ENOG4105F3R pts system mannose fructose sorbose family iid C7M28_00817 ENOG4105ETZ PTS System C7M28_00818 ENOG4108IQ3 PTS system C7M28_00819 ENOG4105YHU PTS system C7M28_00820 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family C7M28_00821 ENOG4105C85 amino acid C7M28_00822 ENOG4105N14 lysine exporter protein LysE YggA C7M28_00823 ENOG4108NGU Transcriptional regulator C7M28_00824 ENOG4105JVQ RNA Polymerase C7M28_00825 ENOG4108P49 AntiSigma factor C7M28_00826 ENOG4105EXC Acyl-transferase C7M28_00827 ENOG4105WDR C7M28_00832 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR C7M28_00833 ENOG4105C84 Histidine ammonia-lyase C7M28_00834 ENOG4105ZXK Dehydrogenase C7M28_00838 ENOG4105CJ1 ABC, transporter C7M28_00839 ENOG4108IAJ Nad-dependent epimerase dehydratase C7M28_00841 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C7M28_00842 ENOG41082JN Transcriptional regulator C7M28_00846 ENOG4105TMB Formate nitrite transporter C7M28_00847 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) C7M28_00848 ENOG4108JB9 formate dehydrogenase C7M28_00851 ENOG4105C28 cystathionine C7M28_00854 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) C7M28_00857 ENOG4107XRG penicillin-binding protein C7M28_00858 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) C7M28_00859 ENOG4105DBI uridine monophosphokinase C7M28_00860 ENOG4105CFP Peptidase U32 C7M28_00861 ENOG4105XYU peptidase (U32 family) C7M28_00863 ENOG4105HHA aminodeoxychorismate lyase C7M28_00864 ENOG4105VPH UPF0473 protein C7M28_00865 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) C7M28_00866 ENOG4105VBH UPF0297 protein C7M28_00867 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) C7M28_00868 ENOG4105C02 permease C7M28_00869 ENOG4105CDA abc transporter atp-binding protein C7M28_00870 ENOG4105CT1 (ABC) transporter C7M28_00871 ENOG4105EAD ABC transporter C7M28_00872 ENOG4105DRP amino acid AbC transporter C7M28_00874 ENOG41060CR C7M28_00876 ENOG4105C7H Helicase, RecD TraA family C7M28_00878 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) C7M28_00879 ENOG4105C3J Cysteine desulfurase C7M28_00881 ENOG4105D1H recombination factor protein RarA C7M28_00882 ENOG4105CUZ uba thif-type nad fad binding protein C7M28_00883 ENOG4105C9M aspartyl-trna synthetase C7M28_00884 ENOG4105CUT histidyl-tRNA synthetase C7M28_00886 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C7M28_00888 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) C7M28_00889 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) C7M28_00890 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) C7M28_00891 ENOG41067VP Protein of unknown function (DUF1049) C7M28_00892 ENOG4105NCW Trka-c domain protein C7M28_00893 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) C7M28_00895 ENOG4105CKP Polysaccharide Biosynthesis Protein C7M28_00896 ENOG4108QG2 Membrane C7M28_00897 ENOG4105NAP C7M28_00898 ENOG4105VIE preprotein translocase, subunit YajC C7M28_00899 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) C7M28_00900 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) C7M28_00901 ENOG41061AI Protein of unknown function (DUF2905) C7M28_00902 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) C7M28_00903 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) C7M28_00905 ENOG4105IE8 Alpha-ketoglutarate permease C7M28_00906 ENOG4105CK5 oxidoreductase C7M28_00910 ENOG4105BZG amino acid carrier protein C7M28_00911 ENOG4105CDY transcriptional regulatory protein C7M28_00913 ENOG4106678 morphogenetic protein associated with SpoVID C7M28_00914 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) C7M28_00915 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase C7M28_00916 ENOG4108IYU L-aspartate oxidase C7M28_00919 ENOG4105CQC Prephenate dehydratase C7M28_00920 ENOG41090I5 UPF0735 ACT domain-containing protein C7M28_00921 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control C7M28_00923 ENOG4105K46 50S ribosomal protein l27 C7M28_00924 ENOG4105X36 (ribosomal) protein C7M28_00925 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) C7M28_00928 ENOG4107QMS site-determining protein C7M28_00929 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) C7M28_00930 ENOG4105YHC Rod shape-determining protein MreD C7M28_00932 ENOG4105DFF Rod shape-determining protein mreb C7M28_00933 ENOG4105W5Q DNA repair protein (RadC C7M28_00934 ENOG4108Z03 MAF-like protein C7M28_00936 ENOG4106A3R peptidase C7M28_00937 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase C7M28_00938 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) C7M28_00940 ENOG4106AR7 Spore coat protein C7M28_00941 ENOG41068KH stage VI sporulation protein D C7M28_00942 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase C7M28_00943 ENOG4105D52 delta-aminolevulinic acid dehydratase C7M28_00945 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) C7M28_00947 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) C7M28_00949 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) C7M28_00950 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) C7M28_00951 ENOG4108IUQ atp-dependent protease C7M28_00952 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) C7M28_00953 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation C7M28_00955 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C7M28_00956 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) C7M28_00957 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C7M28_00958 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) C7M28_00959 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase C7M28_00960 ENOG4108ZP8 Acetolactate synthase small subunit C7M28_00961 ENOG4105C7K acetolactate synthase C7M28_00963 ENOG4105I4A GCN5-related N-acetyltransferase C7M28_00964 ENOG4107KM7 Heat induced stress protein YflT C7M28_00966 ENOG4105M59 Phosphodiesterase, mj0936 family C7M28_00967 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) C7M28_00968 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) C7M28_00969 ENOG4108XJQ germination protein C7M28_00970 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) C7M28_00971 ENOG41067TZ transcriptional regulator, MarR family C7M28_00972 ENOG4105PFC Transcriptional regulator C7M28_00974 ENOG4105E33 succinate dehydrogenase C7M28_00976 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit C7M28_00978 ENOG4105CFH Aspartokinase C7M28_00979 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) C7M28_00980 ENOG4105K63 Thioredoxin C7M28_00981 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) C7M28_00983 ENOG4105C10 Electron transfer flavoprotein C7M28_00984 ENOG4105BZJ Electron transfer flavoprotein C7M28_00985 ENOG41060WC Enoyl-CoA hydratase C7M28_00986 ENOG4107Z3H Transcriptional regulator, TetR family C7M28_00987 ENOG4105CEY Amp-dependent synthetase and ligase C7M28_00989 ENOG4105C98 muts2 protein C7M28_00990 ENOG4105DCG PHP domain protein C7M28_00993 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C7M28_00994 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) C7M28_00995 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) C7M28_00996 ENOG4108RWN rrna methyltransferase C7M28_00997 ENOG41067MF small acid-soluble spore protein C7M28_00999 ENOG4105CQB FAD linked oxidase domain protein C7M28_01000 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C7M28_01003 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) C7M28_01004 ENOG4105DRS transport system, permease C7M28_01007 ENOG4108MDK Dehydrogenase C7M28_01009 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase C7M28_01010 ENOG4105EF1 ribulokinase C7M28_01012 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase C7M28_01013 ENOG4105CN9 Peptidase m42 family protein C7M28_01015 ENOG410696E Membrane C7M28_01016 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) C7M28_01017 ENOG4105VJV 50s ribosomal protein L35 C7M28_01018 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) C7M28_01020 ENOG41067MG lrgb family C7M28_01022 ENOG4105DY9 regulatoR C7M28_01023 ENOG4108HRK Histidine kinase C7M28_01025 ENOG4105C22 threonyL-tRNA synthetase C7M28_01026 ENOG4108TDW sporulation protein YtxC C7M28_01030 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) C7M28_01031 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) C7M28_01032 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C7M28_01033 ENOG4105KVH Transcriptional regulator C7M28_01034 ENOG4105F27 Major Facilitator C7M28_01035 ENOG4105CV8 reductase C7M28_01036 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) C7M28_01038 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) C7M28_01039 ENOG4105C2M dna polymerase I C7M28_01040 ENOG4105BZU Histidine kinase C7M28_01041 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C7M28_01042 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C7M28_01043 ENOG4108HMX isocitrate dehydrogenase (NADP) C7M28_01044 ENOG4105BZN citrate synthase C7M28_01046 ENOG4108REF Sporulation integral membrane protein ytvi C7M28_01047 ENOG4105FS0 cytoplasmic membrane protein C7M28_01048 ENOG4105CA9 Pyruvate kinase C7M28_01049 ENOG4105CTQ phosphohexokinase C7M28_01051 ENOG4108IEY Carboxyl transferase domain C7M28_01052 ENOG4105C6K Malic enzyme C7M28_01053 ENOG4105C0B DNA polymerase III (alpha subunit) C7M28_01054 ENOG4105VV2 C7M28_01056 ENOG4106EVM C7M28_01057 ENOG4105SFS phosphoesterase RecJ domain protein C7M28_01060 ENOG410635A Membrane C7M28_01061 ENOG4105CH2 amidohydrolase C7M28_01065 ENOG4105DEN Luciferase family C7M28_01066 ENOG4105CDA abc transporter atp-binding protein C7M28_01071 ENOG4108XSB acetyltransferase, (GNAT) family C7M28_01072 ENOG4108KSA LysR family transcriptional regulator C7M28_01073 ENOG4105E8R UPF0173 metal-dependent hydrolase C7M28_01076 ENOG4105CH7 arginosuccinase C7M28_01077 ENOG4105CDH Citrulline--aspartate ligase C7M28_01078 ENOG4105EPU Molybdenum cofactor synthesis domain protein C7M28_01079 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) C7M28_01081 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) C7M28_01082 ENOG4105KBJ sporulation protein ytfj C7M28_01084 ENOG4105VK3 rdd domain containing protein C7M28_01085 ENOG4105D07 Signal peptide peptidase, SppA C7M28_01086 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C7M28_01087 ENOG4105EFZ amidohydrolase C7M28_01088 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) C7M28_01095 ENOG4105U5Y Transcriptional regulator C7M28_01097 ENOG4105BZU Histidine kinase C7M28_01098 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) C7M28_01100 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C7M28_01102 ENOG4105F1V Acetoin utilization protein C7M28_01103 ENOG4105W87 Cbs domain C7M28_01104 ENOG4105DGU Histone deacetylase C7M28_01105 ENOG4105ER2 Ompa motb domain protein C7M28_01106 ENOG4107R0U MotA TolQ exbB proton channel C7M28_01107 ENOG4105ETE Transcriptional regulator (LacI family C7M28_01108 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase C7M28_01112 ENOG4105DFU Cell wall formation (By similarity) C7M28_01114 ENOG4108VDD TRNA binding domain protein C7M28_01117 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ C7M28_01120 ENOG4105C6K Malic enzyme C7M28_01121 ENOG4105C8F Beta-lactamase domain protein C7M28_01122 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) C7M28_01124 ENOG4108V15 phosphotransferase enzyme family C7M28_01125 ENOG4108IUM Glycogen debranching enzyme C7M28_01128 ENOG4107F58 2'-5' rna ligase C7M28_01129 ENOG4105C6T cysteine synthase C7M28_01130 ENOG4107QSE Dipeptidase C7M28_01131 ENOG4105C7N Xanthine uracil vitamin C permease C7M28_01134 ENOG4105YW5 deoR family transcriptional regulator C7M28_01137 ENOG4105CBX hi0933 family C7M28_01138 ENOG4105C94 Transporter C7M28_01140 ENOG4105MU9 integral membrane protein C7M28_01141 ENOG4105DDC Oxidoreductase domain protein C7M28_01143 ENOG4105F5H Glycosyl Hydrolase Family 88 C7M28_01145 ENOG41075H3 AraC family transcriptional regulator C7M28_01147 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component C7M28_01149 ENOG4106A3M Cytochrome p-450 C7M28_01150 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) C7M28_01152 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) C7M28_01153 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C7M28_01155 ENOG4105NTD Inherit from COG: Hydrolase C7M28_01161 ENOG41085GJ domain protein C7M28_01162 ENOG4105C8T Leucyl-tRNA synthetase C7M28_01164 ENOG4105BZU Histidine kinase C7M28_01165 ENOG410605W Major Facilitator C7M28_01166 ENOG4106UBQ C7M28_01168 ENOG4105C19 ABC transporter C7M28_01169 ENOG4105EWM Histidine kinase C7M28_01171 ENOG4107R34 abc transporter permease protein C7M28_01172 ENOG4105C19 ABC transporter C7M28_01175 ENOG4105DVE abc transporter atp-binding protein C7M28_01176 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family C7M28_01179 ENOG4105N5T Radical SAM Protein C7M28_01182 ENOG4105E8V Alpha Beta Hydrolase Fold protein C7M28_01183 ENOG4108Z0R Transferase C7M28_01184 ENOG4105C85 amino acid C7M28_01185 ENOG4105CAQ asparagine synthetase C7M28_01186 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP C7M28_01187 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase C7M28_01190 ENOG4105D2X ABC transporter substrate-binding protein C7M28_01192 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component C7M28_01195 ENOG4108RMU ferritin dps family protein C7M28_01198 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) C7M28_01199 ENOG4108V2W Carbonate dehydratase C7M28_01204 ENOG4105CC5 ABC transporter C7M28_01205 ENOG4105CC5 ABC transporter C7M28_01206 ENOG4105DIK (ABC) transporter C7M28_01207 ENOG4105DSE periplasmic solute binding protein C7M28_01208 ENOG4105DTQ mandelate racemase muconate lactonizing C7M28_01209 ENOG4105CEY Amp-dependent synthetase and ligase C7M28_01210 ENOG4108IPT Naphthoate synthase C7M28_01211 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) C7M28_01212 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) C7M28_01213 ENOG4105E4F Isochorismate synthase C7M28_01217 ENOG4108IAJ Nad-dependent epimerase dehydratase C7M28_01218 ENOG4107SBE Glycosyl transferase (Group 1 C7M28_01221 ENOG4107SBE Glycosyl transferase (Group 1 C7M28_01222 ENOG4108KS4 Spore coat protein C7M28_01225 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) C7M28_01227 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) C7M28_01253 ENOG4105N67 Proton-coupled thiamine transporter YuaJ C7M28_01254 ENOG4105VRR gCN5-related N-acetyltransferase C7M28_01255 ENOG4105DZ6 Band 7 protein C7M28_01257 ENOG4106DF1 C7M28_01258 ENOG4108VNY MOSC domain protein C7M28_01259 ENOG4108JB8 alcohol dehydrogenase C7M28_01261 ENOG4105TRT Transcriptional regulator C7M28_01264 ENOG4105CZN Potassium uptake protein C7M28_01265 ENOG4107I77 yiaA/B two helix domain C7M28_01266 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj C7M28_01270 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) C7M28_01272 ENOG4105EE0 oxidoreductase C7M28_01273 ENOG4105DKG l-rhamnose isomerase C7M28_01274 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) C7M28_01275 ENOG4105DET Rhamnulokinase C7M28_01276 ENOG4105E98 transcriptional regulator DeoR family C7M28_01279 ENOG4105C8Q Methyl-accepting chemotaxis C7M28_01280 ENOG4105C8Q Methyl-accepting chemotaxis C7M28_01281 ENOG4105C8Q Methyl-accepting chemotaxis C7M28_01282 ENOG4105C8Q Methyl-accepting chemotaxis C7M28_01285 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme C7M28_01287 ENOG4105C37 (CBS) domain C7M28_01290 ENOG4107PBV potassium channel C7M28_01291 ENOG4107PBV potassium channel C7M28_01294 ENOG4107QYV phosphohexose isomerase C7M28_01296 ENOG4107QW4 alcohol dehydrogenase C7M28_01297 ENOG4105WG9 Conserved Protein C7M28_01299 ENOG4105CHM Aminotransferase C7M28_01300 ENOG4108ZB6 transcriptional regulator AsnC family C7M28_01301 ENOG4108MUZ hydrolase C7M28_01303 ENOG4105C87 Aminotransferase class I and II C7M28_01304 ENOG4108HGU Histidine kinase C7M28_01305 ENOG4105Y38 Kinase-associated protein B C7M28_01309 ENOG4105BZ4 penicillin-binding protein C7M28_01310 ENOG4105KIR Thiol-disulfide oxidoreductase dcc C7M28_01313 ENOG4108MRH transcriptional regulatory protein C7M28_01314 ENOG4105DIH basic membrane C7M28_01315 ENOG4108JQ9 ABC transporter C7M28_01316 ENOG4105UIB (ABC) transporter C7M28_01320 ENOG4105D65 subunit l C7M28_01321 ENOG4105HC0 Na H antiporter C7M28_01322 ENOG4108ZE9 Monovalent cation H antiporter subunit C C7M28_01323 ENOG4108JPZ Monovalent cation H antiporter subunit D C7M28_01324 ENOG4105SC1 monovalent cation H antiporter subunit E C7M28_01326 ENOG4105KJM monovalent cation h antiporter subunit g C7M28_01327 ENOG4105KA0 thioesterase Superfamily protein C7M28_01329 ENOG4105BZU Histidine kinase C7M28_01335 ENOG4105D58 Diguanylate phosphodiesterase C7M28_01336 ENOG4105DAP Nicotinate phosphoribosyltransferase C7M28_01341 ENOG4105C02 permease C7M28_01345 ENOG410904N short-chain dehydrogenase reductase C7M28_01352 ENOG4108K8K Transcriptional regulator C7M28_01353 ENOG4105DCF alanine dehydrogenase C7M28_01355 ENOG4105WQT MbtH domain protein C7M28_01356 ENOG4105CEY Amp-dependent synthetase and ligase C7M28_01357 ENOG4105WQI isochorismatase C7M28_01358 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase C7M28_01359 ENOG4105E4F Isochorismate synthase C7M28_01360 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase C7M28_01361 ENOG4105NIV Esterase C7M28_01365 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) C7M28_01367 ENOG41069ER domain protein C7M28_01369 ENOG4105CEP NADH dehydrogenase C7M28_01370 ENOG4105CAY ferredoxin--nadp reductase C7M28_01374 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 C7M28_01375 ENOG4108YX9 iron--sulfur cluster insertion protein erpA C7M28_01378 ENOG4105ZKE UPF0349 protein C7M28_01381 ENOG41083MR nifu domain-containing protein C7M28_01382 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein C7M28_01383 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) C7M28_01384 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) C7M28_01385 ENOG4105D6E homoserine dehydrogenase C7M28_01387 ENOG4108W5N phosphatidylglycerophosphatase a C7M28_01388 ENOG4105D4U had-superfamily hydrolase, subfamily iia C7M28_01390 ENOG4105MMD transcriptional regulator C7M28_01391 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) C7M28_01392 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) C7M28_01393 ENOG4105FAA peptidase M23 C7M28_01394 ENOG4108YTE sporulation protein YunB C7M28_01395 ENOG4105KZD Domain of unknown function (DUF1805) C7M28_01396 ENOG4107R8B 5'-nucleotidase C7M28_01398 ENOG4105I3N Conserved Protein C7M28_01400 ENOG4105CD3 dihydroorotase C7M28_01401 ENOG4105G9B Transcriptional regulator C7M28_01404 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) C7M28_01405 ENOG4105VT2 5-hydroxyisourate hydrolase C7M28_01406 ENOG4107YV9 domain protein C7M28_01407 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding C7M28_01410 ENOG4105XRQ Xanthine dehydrogenase accessory factor C7M28_01412 ENOG4105C5R Aminotransferase C7M28_01414 ENOG4108K8S endonuclease I C7M28_01415 ENOG4108IJ9 (ABC) transporter C7M28_01416 ENOG4105FDP GntR family transcriptional regulator C7M28_01417 ENOG4108KPW sugar kinase C7M28_01418 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component C7M28_01419 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component C7M28_01420 ENOG4105XN3 extracellular solute-binding protein family 1 C7M28_01421 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine C7M28_01422 ENOG4105PKS Excinuclease abc c subunit domain protein C7M28_01423 ENOG4107VFR oxidoreductase C7M28_01426 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase C7M28_01427 ENOG4105DIW FeS assembly protein SUFB C7M28_01428 ENOG4108UNV SUF system FeS assembly protein, NifU family C7M28_01429 ENOG4105C9B Cysteine desulfurase C7M28_01430 ENOG4105JRK feS assembly protein SufD C7M28_01431 ENOG4105C3K feS assembly ATPase SufC C7M28_01433 ENOG4105D01 (LipO)protein C7M28_01434 ENOG4108UMI ABC transporter, permease C7M28_01435 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) C7M28_01440 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) C7M28_01441 ENOG41080E8 Transcriptional regulator, Spx MgsR family C7M28_01442 ENOG4105C1G acyl-Coa dehydrogenase C7M28_01443 ENOG4105CHU acetyl-coa acetyltransferase C7M28_01449 ENOG41067TZ transcriptional regulator, MarR family C7M28_01450 ENOG4105C0R drug resistance transporter emrb qaca subfamily C7M28_01451 ENOG4105MDS 4-oxalocrotonate tautomerase C7M28_01453 ENOG4105EGI Transcriptional regulator C7M28_01455 ENOG4105E0A ABC, transporter C7M28_01458 ENOG4105E1F short-chain dehydrogenase reductase C7M28_01459 ENOG4105HUF DNA protection during starvation protein C7M28_01460 ENOG4105C0H protease C7M28_01462 ENOG4105F3H Histidine kinase C7M28_01463 ENOG41067SE Tetr family transcriptional regulator C7M28_01464 ENOG4105C9Q fumarate hydratase class II C7M28_01469 ENOG4105WH1 Two component transcriptional regulator luxr family C7M28_01470 ENOG4105ENE Histidine kinase C7M28_01473 ENOG41087YS Phage shock protein A C7M28_01476 ENOG4108WBT adenosyltransferase C7M28_01477 ENOG4105E0A ABC, transporter C7M28_01478 ENOG4105EHG Permease protein C7M28_01479 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) C7M28_01480 ENOG4105EWI Short-chain dehydrogenase reductase Sdr C7M28_01481 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein C7M28_01483 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C7M28_01485 ENOG4106DF4 Sigma-70, region 4 C7M28_01487 ENOG4105F0F Oxalate decarboxylase C7M28_01489 ENOG4107RBB ABC transporter, permease C7M28_01490 ENOG4105C19 ABC transporter C7M28_01491 ENOG4108WMK Efflux transporter RND family MFP subunit C7M28_01492 ENOG4105E0A ABC, transporter C7M28_01493 ENOG4105EHG Permease protein C7M28_01494 ENOG4105DQ5 transport system permease protein C7M28_01497 ENOG4105D5Q Arginine ornithine antiporter C7M28_01499 ENOG4107K5X Membrane-bound metal-dependent hydrolase C7M28_01500 ENOG4107QZ2 Sulfatase C7M28_01501 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family C7M28_01502 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein C7M28_01503 ENOG4105E0C molybdate abc transporter C7M28_01506 ENOG4105EEQ Na H antiporter C7M28_01507 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) C7M28_01508 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C7M28_01509 ENOG4105EEM helicase C7M28_01511 ENOG4105EN6 Membrane C7M28_01513 ENOG4107ZQN disulfide bond C7M28_01514 ENOG4105C59 p-type ATPase C7M28_01515 ENOG4105C59 p-type ATPase C7M28_01516 ENOG410681U heavy metal transport detoxification protein C7M28_01517 ENOG4105VPX protein, conserved in bacteria C7M28_01518 ENOG4105D9R oxidoreductase C7M28_01519 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) C7M28_01520 ENOG4105ME7 Membrane C7M28_01521 ENOG4105RXJ C7M28_01522 ENOG4105KPY Small multidrug resistance protein C7M28_01523 ENOG4105KBX Transcriptional regulator, TetR family C7M28_01524 ENOG4105EWI Short-chain dehydrogenase reductase Sdr C7M28_01526 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) C7M28_01527 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) C7M28_01529 ENOG4105XZU Preprotein translocase, subunit SecG C7M28_01534 ENOG4105KVH Transcriptional regulator C7M28_01535 ENOG4105C8Q Methyl-accepting chemotaxis C7M28_01536 ENOG4105R40 Glycine betaine carnitine choline C7M28_01537 ENOG4108HQR Glycine betaine C7M28_01538 ENOG4105E90 ABC transporter C7M28_01539 ENOG4108IJ8 ABC transporter C7M28_01540 ENOG4107HG4 Transcriptional regulator C7M28_01541 ENOG4105R40 Glycine betaine carnitine choline C7M28_01542 ENOG4108HQR Glycine betaine C7M28_01543 ENOG4105E90 ABC transporter C7M28_01544 ENOG4108IJ8 ABC transporter C7M28_01545 ENOG4107HG4 Transcriptional regulator C7M28_01546 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein C7M28_01547 ENOG4108QCI YvbH-like oligomerisation region C7M28_01549 ENOG4105T65 Membrane-associated protein C7M28_01550 ENOG4108W0I acetyltransferase C7M28_01551 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) C7M28_01552 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) C7M28_01553 ENOG4105CP7 Triose-phosphate isomerase C7M28_01554 ENOG4105BZA Phosphoglycerate kinase C7M28_01555 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase C7M28_01558 ENOG4105CMD Transcriptional regulator, GntR family C7M28_01559 ENOG4105DEN Luciferase family C7M28_01560 ENOG4105GZI Transcriptional regulator C7M28_01561 ENOG4107RT3 EamA-like transporter family C7M28_01563 ENOG4105VRS hydrolase family 18 C7M28_01564 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) C7M28_01565 ENOG4107QR9 Iron-sulfur cluster binding protein C7M28_01566 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) C7M28_01568 ENOG4105BZU Histidine kinase C7M28_01569 ENOG4105KCT ABC transporter C7M28_01570 ENOG4108M15 ABC transporter C7M28_01571 ENOG4107R6F Alpha Beta Hydrolase Fold protein C7M28_01572 ENOG4108MJI response regulator C7M28_01575 ENOG4105EG2 ABC transporter, permease C7M28_01577 ENOG4107FKK extracellular solute-binding protein family 1 C7M28_01579 ENOG4105JXH GntR family transcriptional regulator C7M28_01580 ENOG4105DAA L-lactate C7M28_01581 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C7M28_01583 ENOG4108ZPC Polysaccharide pyruvyl transferase C7M28_01584 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C7M28_01585 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family C7M28_01586 ENOG4105D3Q Sugar transferase C7M28_01588 ENOG4105K64 Glycosyl transferase, family 2 C7M28_01590 ENOG4107QRS glycosyltransferase group 2 family protein C7M28_01591 ENOG41068W6 Capsular polysaccharide biosynthesis protein C7M28_01592 ENOG4108KMV Glycosyl transferase (Group 1 C7M28_01593 ENOG4105K64 Glycosyl transferase, family 2 C7M28_01594 ENOG4108PQP glycosyl transferase group 1 C7M28_01596 ENOG4108QV3 biosynthesis protein C7M28_01597 ENOG4105HTX biosynthesis protein C7M28_01599 ENOG4105EBR Carboxylesterase C7M28_01601 ENOG4105PY6 Phenolic acid decarboxylase C7M28_01602 ENOG4105NI3 Protein of unknown function (DUF3237) C7M28_01604 ENOG4105FQP Beta-lactamase C7M28_01605 ENOG4105EDQ levansucrase EC 2.4.1.10 C7M28_01606 ENOG4108HKT sucrose-6-phosphate hydrolase C7M28_01607 ENOG4107QTZ amino acid C7M28_01612 ENOG4105DNP FAD linked oxidase domain protein C7M28_01613 ENOG4105IRW patatin-like phospholipase family protein C7M28_01615 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) C7M28_01616 ENOG4107URF beta-phospho-glucomutase C7M28_01617 ENOG4105CG3 alpha amylase, catalytic region C7M28_01620 ENOG4105EG2 ABC transporter, permease C7M28_01621 ENOG4105D56 permease protein C7M28_01622 ENOG4107FKK extracellular solute-binding protein family 1 C7M28_01623 ENOG4108IUK alpha amylase, catalytic C7M28_01624 ENOG4105FKQ transcriptional regulator C7M28_01625 ENOG4108URH decarboxylase C7M28_01626 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain C7M28_01627 ENOG4105CHH sulfate transporter C7M28_01628 ENOG4108V2W Carbonate dehydratase C7M28_01629 ENOG4105C5I Dehydrogenase C7M28_01631 ENOG4105C19 ABC transporter C7M28_01632 ENOG4105EWM Histidine kinase C7M28_01634 ENOG4107A6P C7M28_01635 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase C7M28_01636 ENOG4105KRI phosphocarrier protein (HPr C7M28_01637 ENOG4105CIE May be required for sporulation (By similarity) C7M28_01638 ENOG4105CHW UPF0052 protein C7M28_01639 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) C7M28_01640 ENOG4108Z4K mutator MutT protein C7M28_01641 ENOG4105C3M thioredoxin reductase C7M28_01644 ENOG4105BZ1 (ABC) transporter C7M28_01646 ENOG4106FGC C7M28_01649 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase C7M28_01650 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) C7M28_01651 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase C7M28_01652 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) C7M28_01653 ENOG4105ECC imidazole-glycerol-phosphate dehydratase C7M28_01654 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) C7M28_01655 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) C7M28_01656 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) C7M28_01658 ENOG4108E16 pectate lyase C7M28_01659 ENOG4108S4C acetyltransferase C7M28_01660 ENOG4107XGZ Hydrolase C7M28_01661 ENOG4105HKU nucleoside recognition domain-containing protein C7M28_01662 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) C7M28_01663 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) C7M28_01664 ENOG4105CE4 GlcNAc 6-P deacetylase C7M28_01665 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) C7M28_01667 ENOG41088CQ domain protein C7M28_01669 ENOG4106A3M Cytochrome p-450 C7M28_01670 ENOG410625E C7M28_01673 ENOG41086DT Membrane protein of unknown function C7M28_01674 ENOG41067S9 phage shock protein C, PspC C7M28_01675 ENOG4108PY7 C7M28_01679 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) C7M28_01680 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) C7M28_01683 ENOG4105MKU Transcriptional regulator C7M28_01687 ENOG4105CN1 protease C7M28_01688 ENOG4105CRP Part of the ABC transporter FtsEX involved in C7M28_01689 ENOG4105CAK Cell division ATP-binding protein ftsE C7M28_01692 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) C7M28_01694 ENOG4105MS2 ribosomal subunit Interface protein C7M28_01697 ENOG4105MQ3 flagellar protein FliS C7M28_01698 ENOG4107RT6 flagellar hook-associated C7M28_01699 ENOG41083S7 flagellar protein FlaG C7M28_01700 ENOG4105I03 Flagellin C7M28_01701 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) C7M28_01702 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) C7M28_01703 ENOG4105MKD C7M28_01704 ENOG4105DTJ flagellar hook-associated protein C7M28_01705 ENOG4105E1Q flagellar hook-associated protein C7M28_01708 ENOG4105RU3 C7M28_01709 ENOG41081UC Inherit from COG: Competence protein C7M28_01713 ENOG4105WH1 Two component transcriptional regulator luxr family C7M28_01714 ENOG4105BZU Histidine kinase C7M28_01715 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein C7M28_01716 ENOG4108KGH TRANSCRIPTIONal C7M28_01717 ENOG4105ESV Glycosyl transferase, family 4 C7M28_01718 ENOG4107EF8 Glycosyl transferase (Group 1 C7M28_01721 ENOG4105QZI O-Antigen Polymerase C7M28_01722 ENOG4105C6Y Udp-glucose 6-dehydrogenase C7M28_01723 ENOG4107RA4 Glycosyl transferase (Group 1 C7M28_01724 ENOG4105PSV Polysaccharide Biosynthesis Protein C7M28_01725 ENOG4105D3Q Sugar transferase C7M28_01726 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase C7M28_01727 ENOG4105JFG SpoIID LytB domain protein C7M28_01730 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase C7M28_01731 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C7M28_01733 ENOG4107VDP teichoic acid biosynthesis C7M28_01734 ENOG41088M2 Glycosyl transferase family 2 C7M28_01736 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C7M28_01737 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase C7M28_01738 ENOG4105EY8 ABC transporter C7M28_01740 ENOG4107SJB teichoic acid biosynthesis C7M28_01741 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) C7M28_01742 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase C7M28_01744 ENOG4107RZX Teichoic acid biosynthesis protein C7M28_01745 ENOG410651K Teichoic acid biosynthesis protein C C7M28_01747 ENOG4105DG6 mannose-6-phosphate isomerase C7M28_01750 ENOG4108NHD germination protein C7M28_01751 ENOG4105C54 Major Facilitator superfamily C7M28_01752 ENOG4108KGH TRANSCRIPTIONal C7M28_01753 ENOG4105J7I hydrolase C7M28_01754 ENOG4105K4H Nlp p60 protein C7M28_01756 ENOG4105PNM synthesis protein C7M28_01758 ENOG4105N98 Capsule biosynthesis protein capB C7M28_01759 ENOG4105ETE Transcriptional regulator (LacI family C7M28_01760 ENOG4108RVA ribokinase C7M28_01761 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) C7M28_01762 ENOG4105C2J ABC transporter C7M28_01763 ENOG4105CNN ABC, transporter C7M28_01764 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator C7M28_01767 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein C7M28_01768 ENOG4107FQX Alpha-acetolactate decarboxylase C7M28_01770 ENOG4107RSM transcriptional regulator C7M28_01773 ENOG4106UIA C7M28_01776 ENOG4107XC4 flavin reductase domain protein, FMN-binding C7M28_01778 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) C7M28_01780 ENOG4105CAH Chromate C7M28_01781 ENOG4105FGV Chromate C7M28_01783 ENOG4108WS4 fmn reductase C7M28_01784 ENOG4107V2S Transcriptional regulator C7M28_01785 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) C7M28_01793 ENOG4108XI2 Domain of unknown function (DUF1963) C7M28_01794 ENOG4105C6Y Udp-glucose 6-dehydrogenase C7M28_01795 ENOG4108RB3 Capsular polysaccharide biosynthesis protein C7M28_01796 ENOG4107YJ4 chain length determinant protein C7M28_01797 ENOG4105HTX biosynthesis protein C7M28_01799 ENOG4105KBK Zinc finger, swim domain protein C7M28_01800 ENOG4105C0D helicase C7M28_01801 ENOG410667J hydrolase C7M28_01802 ENOG4105E98 transcriptional regulator DeoR family C7M28_01803 ENOG4105Z8H single-stranded DNA-binding protein C7M28_01808 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) C7M28_01809 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) C7M28_01811 ENOG4105CGA flagellar basal-body rod protein FlgG C7M28_01813 ENOG4105DFF Rod shape-determining protein mreb C7M28_01814 ENOG4105MT0 Sporulation transcriptional regulator spoiiid C7M28_01815 ENOG4107MII Sugar-specific transcriptional regulator TrmB C7M28_01816 ENOG4105CZM Major Facilitator C7M28_01817 ENOG4108M26 parallel beta-helix repeat protein C7M28_01818 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease C7M28_01819 ENOG41080V3 Major Facilitator superfamily C7M28_01820 ENOG4105D3W isochorismatase C7M28_01821 ENOG4107P26 C7M28_01822 ENOG4105BZU Histidine kinase C7M28_01824 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase C7M28_01826 ENOG4105FRN stage II sporulation protein C7M28_01827 ENOG4107TCE N-acetyltransferase C7M28_01830 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C7M28_01831 ENOG4107TXC Transcriptional regulator C7M28_01832 ENOG4106BRK C7M28_01833 ENOG4108RYK Nad-dependent epimerase dehydratase C7M28_01834 ENOG4108Z40 Transcriptional regulator C7M28_01835 ENOG4105CQM Urea amidohydrolase subunit alpha C7M28_01836 ENOG4105KI2 Urea amidohydrolase subunit beta C7M28_01837 ENOG4108YZ9 Urea amidohydrolase subunit gamma C7M28_01843 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) C7M28_01845 ENOG4108TF4 von Willebrand factor, type A C7M28_01847 ENOG4105JFG SpoIID LytB domain protein C7M28_01848 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C7M28_01850 ENOG4106778 Protein of unknown function (DUF1146) C7M28_01853 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) C7M28_01854 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) C7M28_01855 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) C7M28_01856 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) C7M28_01860 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) C7M28_01862 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) C7M28_01863 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) C7M28_01864 ENOG4108UIC UPF0340 protein C7M28_01865 ENOG4108YZG isomerase C7M28_01866 ENOG4107WAU Protein tyrosine phosphatase C7M28_01867 ENOG410815N Probably functions as a manganese efflux pump (By similarity) C7M28_01868 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C7M28_01870 ENOG4108ZXQ stage ii sporulation protein r C7M28_01873 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) C7M28_01874 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) C7M28_01875 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase C7M28_01877 ENOG4107TT2 Auxin Efflux Carrier C7M28_01878 ENOG4105C6K Malic enzyme C7M28_01879 ENOG4107104 thymidine kinase C7M28_01881 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) C7M28_01882 ENOG4105CBT Fructose-1,6-bisphosphatase C7M28_01883 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) C7M28_01884 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway C7M28_01885 ENOG4105D2N Aldolase C7M28_01886 ENOG410812K response regulator receiver protein C7M28_01888 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) C7M28_01890 ENOG4105C1G acyl-Coa dehydrogenase C7M28_01891 ENOG4105DF6 Fe-S oxidoreductase C7M28_01893 ENOG4105E5J UV damage endonuclease C7M28_01895 ENOG4105NAE bifunctional deaminase-reductase domain protein C7M28_01896 ENOG4105BZ1 (ABC) transporter C7M28_01897 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) C7M28_01899 ENOG4105R3A Nitrate reductase C7M28_01900 ENOG4108IUE nitrate reductase beta subunit C7M28_01904 ENOG4107V6Q Cyclic nucleotide-binding domain C7M28_01906 ENOG4105C75 arginyL-tRNA synthetase C7M28_01907 ENOG410684U Domain of unknown function (DUF1934) C7M28_01909 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E C7M28_01918 ENOG4107JM4 Tetratricopeptide repeat C7M28_01920 ENOG4108UIN ybak prolyl-trna synthetase associated region C7M28_01921 ENOG4105CYW agmatinase C7M28_01922 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) C7M28_01923 ENOG4105BZ4 penicillin-binding protein C7M28_01925 ENOG4108XFG YwhD family C7M28_01926 ENOG4108Z4T Peptidase M50 C7M28_01927 ENOG41069HH 4-oxalocrotonate tautomerase C7M28_01928 ENOG41067TZ transcriptional regulator, MarR family C7M28_01929 ENOG4105C22 threonyL-tRNA synthetase C7M28_01931 ENOG4105C57 major facilitator superfamily C7M28_01932 ENOG41062ES Transcriptional regulator C7M28_01934 ENOG4105DCI Phosphohydrolase C7M28_01936 ENOG4108VCI transcription factor, rsfa family C7M28_01937 ENOG4108RNG Permease of the drug metabolite transporter C7M28_01938 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) C7M28_01939 ENOG4105DUM transcriptional regulator, lysR family C7M28_01940 ENOG4108IJ2 phosphate acetyltransferase C7M28_01943 ENOG4105CHM Aminotransferase C7M28_01945 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase C7M28_01946 ENOG4105CHR reductase C7M28_01947 ENOG4106CHD Bacilysin biosynthesis protein bacB C7M28_01948 ENOG41061WN bacilysin biosynthesis protein C7M28_01949 ENOG4105FCW Major Facilitator superfamily C7M28_01952 ENOG4105C26 Dehydrogenase C7M28_01953 ENOG4105D82 Glutamate dehydrogenase C7M28_01955 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase C7M28_01956 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase C7M28_01957 ENOG4105C1B dTDP-glucose 4-6-dehydratase C7M28_01958 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) C7M28_01959 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG C7M28_01960 ENOG4107TY6 Acylneuraminate cytidylyltransferase C7M28_01962 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD C7M28_01963 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase C7M28_01970 ENOG4105C26 Dehydrogenase C7M28_01971 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) C7M28_01972 ENOG4108RJ9 Glycosyl transferase, family 2 C7M28_01973 ENOG4105DWF phosphomethylpyrimidine kinase C7M28_01976 ENOG4105C5Y PTS System C7M28_01977 ENOG4108QTI )-transporter C7M28_01980 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin C7M28_01981 ENOG4105DEN Luciferase family C7M28_01982 ENOG4108DBC nitroreductase C7M28_01985 ENOG41060D1 Quinol oxidase C7M28_01986 ENOG4105CCU oxidase (Subunit III) C7M28_01987 ENOG4105BZ9 Cytochrome C oxidase, subunit I C7M28_01988 ENOG4105E2S oxidase) subunit II C7M28_01989 ENOG4107BMA Transglycosylase associated protein C7M28_01991 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) C7M28_01992 ENOG4105WH5 Teichoic acid glycosylation protein C7M28_01997 ENOG4107ZXU DSBA oxidoreductase C7M28_01998 ENOG4105DBE peroxidase C7M28_01999 ENOG410650H (LipO)protein C7M28_02000 ENOG4107SJW iron permease, FTR1 C7M28_02001 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) C7M28_02003 ENOG4105CMU LysR family (Transcriptional regulator C7M28_02004 ENOG4105VAW lrga family C7M28_02005 ENOG41067MG lrgb family C7M28_02006 ENOG4105D8G Major Facilitator superfamily C7M28_02008 ENOG4105DR4 Methyltransferase C7M28_02011 ENOG4108YV3 Protein of unknown function (DUF2711) C7M28_02012 ENOG4105CK1 PTS System C7M28_02013 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin C7M28_02016 ENOG4105X1N Glycosyl transferase family 8 C7M28_02018 ENOG4105GVJ transcriptional regulator C7M28_02019 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) C7M28_02020 ENOG4105IIU Aminopeptidase C7M28_02025 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase C7M28_02027 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) C7M28_02028 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein C7M28_02030 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD C7M28_02031 ENOG4108VHC Short-chain dehydrogenase reductase Sdr C7M28_02032 ENOG4105CM2 brancheD-chain amino acid aminotransferase C7M28_02033 ENOG4105F8D glycoside hydrolase family 4 C7M28_02034 ENOG4105VCP PTS System C7M28_02035 ENOG4105CK1 PTS System C7M28_02036 ENOG4105VZJ PTS System C7M28_02037 ENOG4105EMD TRANSCRIPTIONal C7M28_02039 ENOG4108VX5 3-methyladenine DNA glycosylase C7M28_02040 ENOG4105CH6 catalase C7M28_02043 ENOG4105DA5 (ABC) transporter C7M28_02044 ENOG41069JR C7M28_02048 ENOG4105ETS cytosine purines uracil thiamine allantoin C7M28_02049 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) C7M28_02050 ENOG4108JJ8 (ABC) transporter C7M28_02051 ENOG4108JJ9 ABC, transporter C7M28_02052 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii C7M28_02053 ENOG4105C4M (Ubiquinol oxidase) subunit I C7M28_02054 ENOG4105D2K citrate carrier protein C7M28_02057 ENOG4107BJW polysaccharide deacetylase C7M28_02061 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) C7M28_02063 ENOG4105CMR udp-glucose 4-epimerase C7M28_02065 ENOG4105BZU Histidine kinase C7M28_02066 ENOG4105WH1 Two component transcriptional regulator luxr family C7M28_02067 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) C7M28_02072 ENOG4105DTD Dehydrogenase C7M28_02073 ENOG4108IIH CoA-transferase subunit B C7M28_02074 ENOG4105D6N CoA-transferase, subunit a C7M28_02075 ENOG4105CY2 Citrate transporter C7M28_02076 ENOG4105DHI Methyltransferase C7M28_02080 ENOG4105CH6 catalase C7M28_02081 ENOG4105D4T Citrate transporter C7M28_02082 ENOG4108RZ2 Glycoside hydrolase family 16 C7M28_02083 ENOG4105CID antiterminator C7M28_02085 ENOG4105DEU major facilitator superfamily C7M28_02086 ENOG4105C1J atp-dependent rna helicase C7M28_02087 ENOG4107TDE lipolytic protein G-D-S-L family C7M28_02098 ENOG4105CNA YD repeat protein C7M28_02100 ENOG4107YZX Universal stress protein C7M28_02101 ENOG4105CS2 ec 3.2.1.21 C7M28_02102 ENOG4105C5Y PTS System C7M28_02105 ENOG4107EV6 Inherit from COG: YD repeat protein C7M28_02108 ENOG4106Z5D Glycoside Hydrolase Family 43 C7M28_02110 ENOG4105C84 Histidine ammonia-lyase C7M28_02111 ENOG4105CGP Urocanate hydratase C7M28_02112 ENOG4105CI2 imidazolone-5-propionate hydrolase C7M28_02113 ENOG4107W25 arginase agmatinase formiminoglutamase C7M28_02115 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) C7M28_02116 ENOG4105D9N nucleoside C7M28_02118 ENOG4107RHR regulatoR C7M28_02119 ENOG4108TM9 integral membrane protein C7M28_02120 ENOG4105ENY Ethanolamine utilization protein eutH C7M28_02121 ENOG4108PGP mmge prpd family protein C7M28_02124 ENOG4108HW4 amino acid AbC transporter C7M28_02125 ENOG4105EAB amino acid AbC transporter C7M28_02129 ENOG4107QHE Choloylglycine hydrolase C7M28_02130 ENOG410667J hydrolase C7M28_02136 ENOG4108V5C ABC transporter C7M28_02142 ENOG4105D2N Aldolase C7M28_02143 ENOG4107TRN Xylose isomerase domain protein TIM barrel C7M28_02144 ENOG4105F0H myo-inositol catabolism protein C7M28_02145 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) C7M28_02147 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) C7M28_02148 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) C7M28_02149 ENOG4105D7K pfkb domain protein C7M28_02151 ENOG4105C26 Dehydrogenase C7M28_02153 ENOG4105CPC Aldo Keto reductase C7M28_02156 ENOG4107QNK )-transporter C7M28_02157 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) C7M28_02159 ENOG41061TZ Short-chain dehydrogenase reductase Sdr C7M28_02160 ENOG4105ST3 Transcriptional regulator C7M28_02161 ENOG4105C26 Dehydrogenase C7M28_02162 ENOG4108YM7 Gcn5-related n-acetyltransferase C7M28_02163 ENOG4105N1N Cupin superfamily protein C7M28_02164 ENOG4107Y1Y Methyltransferase C7M28_02167 ENOG4105CAQ asparagine synthetase C7M28_02168 ENOG4105F22 Major Facilitator Superfamily C7M28_02169 ENOG4108ITS PQQ enzyme repeat C7M28_02171 ENOG41085PJ rdd domain containing protein C7M28_02174 ENOG4105J7D transcriptional regulator C7M28_02175 ENOG4107JEE Short-chain dehydrogenase reductase Sdr C7M28_02176 ENOG41061AU MarR family Transcriptional regulator C7M28_02178 ENOG41067MG lrgb family C7M28_02180 ENOG4105BZW Glycerate kinase C7M28_02181 ENOG4105G3Z GntR family transcriptional regulator C7M28_02182 ENOG4105CMG Carbohydrate kinase C7M28_02183 ENOG4105C6Z Gluconate C7M28_02184 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) C7M28_02185 ENOG4105D3R alkyl hydroperoxide reductase C7M28_02186 ENOG4108JU3 Alkyl hydroperoxide reductase C7M28_02187 ENOG4105CS2 ec 3.2.1.21 C7M28_02189 ENOG4108S3Y transcriptional regulator C7M28_02190 ENOG4106KKU C7M28_02191 ENOG4108Z15 abc transporter atp-binding protein C7M28_02192 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 C7M28_02195 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) C7M28_02198 ENOG4105E2A Dehydrogenase C7M28_02202 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) C7M28_02203 ENOG4105WQG acetyltransferase C7M28_02204 ENOG410780I phosphoprotein phosphatase activity C7M28_02206 ENOG41066UZ arginase EC 3.5.3.1 C7M28_02207 ENOG4108IQI permease C7M28_02208 ENOG4105C8Y Acetylornithine aminotransferase C7M28_02213 ENOG41082BM Transcriptional regulator, arsr family C7M28_02214 ENOG4108JUB Transcriptional regulator C7M28_02215 ENOG4105BZU Histidine kinase C7M28_02219 ENOG4105C0H protease C7M28_02220 ENOG4105Q2H domain protein C7M28_02223 ENOG4105BZU Histidine kinase C7M28_02224 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C7M28_02229 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis C7M28_02230 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase C7M28_02231 ENOG4105CDU Replicative dna helicase C7M28_02235 ENOG4105DJ2 Major Facilitator Superfamily C7M28_02236 ENOG4105EDW glycosyl transferase, family 39 C7M28_02237 ENOG4105K9Q Binds to the 23S rRNA (By similarity) C7M28_02238 ENOG4105BZR domain protein C7M28_02239 ENOG4108XMW Membrane C7M28_02242 ENOG4105KVH Transcriptional regulator C7M28_02243 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase C7M28_02247 ENOG41090E6 transcriptional regulator MERR family C7M28_02249 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein C7M28_02250 ENOG4105DDN Pentapeptide repeat-containing protein C7M28_02251 ENOG4105D94 Major Facilitator Superfamily C7M28_02252 ENOG4107RSM transcriptional regulator C7M28_02253 ENOG41082BV acetyltransferase C7M28_02254 ENOG41081I9 integral membrane protein C7M28_02256 ENOG4108U05 Transcriptional regulator C7M28_02257 ENOG41082BV acetyltransferase C7M28_02259 ENOG4108U7W acetyltransferase C7M28_02260 ENOG4105UNS Pfam:DUF419 C7M28_02261 ENOG4105NAE bifunctional deaminase-reductase domain protein C7M28_02262 ENOG4108J8C transporter major facilitator family protein C7M28_02265 ENOG4108IPJ Membrane C7M28_02266 ENOG4105C7Z Conserved Protein C7M28_02271 ENOG4105K4H Nlp p60 protein C7M28_02273 ENOG4105P1M Domain of unknown function (DUF1874) C7M28_02284 ENOG4106128 DNA-binding helix-turn-helix protein C7M28_02285 ENOG4106BHR ftsk SpoIIIE family protein C7M28_02286 ENOG4108RYM conjugative transposon protein C7M28_02289 ENOG4108IMY Transcriptional regulator C7M28_02290 ENOG41068WC Domain of unknown function (DUF955) C7M28_02293 ENOG4105C7Z Conserved Protein C7M28_02297 ENOG4105C7Z Conserved Protein C7M28_02298 ENOG4107FCW Abortive infection protein C7M28_02300 ENOG4108UW5 maltose o-acetyltransferase C7M28_02301 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase C7M28_02303 ENOG4105CGK Exodeoxyribonuclease III C7M28_02304 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) C7M28_02305 ENOG4108UUM single-stranded DNA-binding protein C7M28_02306 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) C7M28_02307 ENOG4105C3G gtp-binding protein C7M28_02308 ENOG4108J2R molybdopterin oxidoreductase C7M28_02309 ENOG4105VDK protein, conserved in bacteria C7M28_02311 ENOG4108ZDA Sporulation protein YyaC C7M28_02312 ENOG4105FA0 parb-like partition protein C7M28_02313 ENOG4107QJE Chromosome Partitioning Protein C7M28_02316 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) C7M28_02317 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) C7M28_02318 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) C7M28_02321 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) C7M28_02322 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) C7M28_02323 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) C7M28_02324 ENOG410848D S4 domain protein YaaA C7M28_02327 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C7M28_02328 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C7M28_02335 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) C7M28_02337 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) C7M28_02338 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) C7M28_02339 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) C7M28_02341 ENOG4105ZMH deoxynucleoside kinase C7M28_02343 ENOG4105VRS hydrolase family 18 C7M28_02344 ENOG4105GTG Isochorismatase C7M28_02345 ENOG4108Z6B deaminase C7M28_02346 ENOG4105C6E dna polymerase iii C7M28_02347 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) C7M28_02348 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) C7M28_02350 ENOG41067KS pro-sigma K processing C7M28_02358 ENOG4105CDW Resistance protein C7M28_02359 ENOG4105CXN decarboxylase C7M28_02360 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) C7M28_02361 ENOG4105X0R protein from nitrogen regulatory protein P-II C7M28_02362 ENOG4105XVJ Protein of unknown function (DUF327) C7M28_02363 ENOG4105FA2 dna polymerase iii C7M28_02364 ENOG4105MA4 psp1 domain protein C7M28_02365 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) C7M28_02366 ENOG41060K3 Methyltransferase C7M28_02367 ENOG4105VC4 domain protein C7M28_02368 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) C7M28_02369 ENOG4105KRN Transcriptional regulator, abrb family C7M28_02370 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) C7M28_02371 ENOG4105F8V Hydrolase, tatD family C7M28_02372 ENOG41069ER domain protein C7M28_02374 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) C7M28_02375 ENOG4105XFA sporulation peptidase YabG C7M28_02376 ENOG4105W42 Veg protein C7M28_02377 ENOG4105XEW small acid-soluble spore protein C7M28_02378 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) C7M28_02379 ENOG4105DFT pur operon repressor C7M28_02380 ENOG4105KME endoribonuclease L-psp C7M28_02381 ENOG4105K4W Could be involved in septation (By similarity) C7M28_02382 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) C7M28_02383 ENOG4105C5T Phosphoribosyl pyrophosphate synthase C7M28_02384 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) C7M28_02385 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) C7M28_02387 ENOG4108JA2 transcriptioN-repair coupling factor C7M28_02388 ENOG4108M14 stage v sporulation protein t C7M28_02390 ENOG4108IY2 MazG family C7M28_02391 ENOG41082I2 s4 domain protein C7M28_02392 ENOG4105VYY sporulation protein yabp C7M28_02395 ENOG41060GV RNA binding s1 domain protein C7M28_02401 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) C7M28_02402 ENOG4108UGV hypoxanthine phosphoribosyltransferase C7M28_02403 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) C7M28_02405 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) C7M28_02406 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase C7M28_02407 ENOG4105C6T cysteine synthase C7M28_02408 ENOG4105CRQ synthase (Component I) C7M28_02409 ENOG4105DDQ anthranilate synthase C7M28_02410 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 C7M28_02411 ENOG4105EEI dihydropteroate synthase C7M28_02412 ENOG4105KRF dihydroneopterin aldolase C7M28_02413 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase C7M28_02415 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) C7M28_02416 ENOG4105CRK lysyL-tRNA synthetase C7M28_02433 ENOG4108Z0C Uvrb UvrC protein C7M28_02434 ENOG41066A3 ATP guanido phosphotransferase C7M28_02436 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) C7M28_02437 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) C7M28_02438 ENOG4105CTP PilT protein domain protein C7M28_02439 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) C7M28_02440 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) C7M28_02441 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) C7M28_02442 ENOG4105D7W serine acetyltransferase C7M28_02443 ENOG4105C8N cysteinyl-tRNA synthetase C7M28_02444 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) C7M28_02445 ENOG4105C2N RNA methyltransferase TrmH family group 3 C7M28_02446 ENOG4105M0M Tetracycline resistance protein C7M28_02449 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) C7M28_02452 ENOG4108VZM 50s ribosomal protein L10 C7M28_02454 ENOG4107Y49 methyltransferase C7M28_02455 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C7M28_02456 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C7M28_02457 ENOG4105XPM ribosomal protein C7M28_02458 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) C7M28_02459 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) C7M28_02460 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) C7M28_02461 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) C7M28_02462 ENOG4107SKW Inherit from COG: Alpha beta hydrolase C7M28_02463 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) C7M28_02464 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) C7M28_02465 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) C7M28_02467 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity C7M28_02470 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) C7M28_02471 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) C7M28_02473 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal C7M28_02474 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) C7M28_02476 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits C7M28_02478 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) C7M28_02479 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) C7M28_02480 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) C7M28_02481 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) C7M28_02483 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) C7M28_02484 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) C7M28_02486 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) C7M28_02488 ENOG41067V7 50S ribosomal protein L36 C7M28_02489 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits C7M28_02490 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) C7M28_02491 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) C7M28_02492 ENOG4108ZT0 50S ribosomal protein l17 C7M28_02493 ENOG4108JJB ABC transporter C7M28_02494 ENOG4108JJB ABC transporter C7M28_02495 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) C7M28_02496 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) C7M28_02497 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) C7M28_02498 ENOG4108UJD 30S ribosomal protein S9 C7M28_02499 ENOG4108I0C methyltransferase C7M28_02502 ENOG4105D1F ATP-binding protein C7M28_02505 ENOG4108NMV polysaccharide deacetylase C7M28_02521 ENOG4105CHH sulfate transporter C7M28_02524 ENOG4108SA1 esterase C7M28_02528 ENOG410874W AraC family transcriptional regulator C7M28_02529 ENOG4105EHZ conserved protein UCP016719 C7M28_02530 ENOG4105D17 glycoside hydrolase, family 3 domain protein C7M28_02534 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate C7M28_02536 ENOG4105EWC Purine nucleoside phosphorylase C7M28_02542 ENOG4105EMN RNA polymerase sigma factor C7M28_02544 ENOG4105C8B TIGR00159 family C7M28_02545 ENOG4107U5W ybbr family C7M28_02546 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) C7M28_02547 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) C7M28_02548 ENOG4105D03 DNA-3-methyladenine glycosylase II C7M28_02550 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C7M28_02551 ENOG4108TWJ NADH dehydrogenase subunit 5 C7M28_02556 ENOG4105GPN Uncharacterized conserved protein (DUF2294) C7M28_02557 ENOG4105WAB arsR family transcriptional regulator C7M28_02558 ENOG4108RWP Major Facilitator Superfamily protein C7M28_02560 ENOG4107ZBH radical SAM domain protein C7M28_02561 ENOG41066N6 Abortive infection protein C7M28_02562 ENOG4108WUZ (ABC) transporter C7M28_02570 ENOG4105G0J serine threonine protein kinase C7M28_02572 ENOG4106K80 C7M28_02574 ENOG4106DDH Sporulation-specific SASP protein C7M28_02576 ENOG4108HWY Beta-lactamase C7M28_02577 ENOG4107E6A Cytochrome p-450 C7M28_02579 ENOG4107QTZ amino acid C7M28_02580 ENOG4107VXM glycerophosphoryl diester phosphodiesterase C7M28_02581 ENOG4105CXY transporter C7M28_02583 ENOG410645S MarR family Transcriptional regulator C7M28_02584 ENOG4105DCM major facilitator superfamily C7M28_02588 ENOG410631K Membrane C7M28_02589 ENOG4106AXJ AraC family transcriptional regulator C7M28_02590 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR C7M28_02591 ENOG4108TCS Glutamyl endopeptidase C7M28_02593 ENOG4108WC5 Alpha Beta Hydrolase Fold protein C7M28_02594 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase C7M28_02595 ENOG4107ZTW SNARE associated Golgi C7M28_02599 ENOG4105C72 UPF0176 protein C7M28_02601 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane C7M28_02602 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) C7M28_02605 ENOG4105CM2 brancheD-chain amino acid aminotransferase C7M28_02606 ENOG4108IQI permease C7M28_02607 ENOG4108J5H Homocysteine s-methyltransferase C7M28_02609 ENOG4105CSV Glutaminase C7M28_02612 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase C7M28_02613 ENOG4105C26 Dehydrogenase C7M28_02614 ENOG4105DJB Major Facilitator Superfamily C7M28_02615 ENOG4105EQX glucarate dehydratase C7M28_02616 ENOG41073TP transcriptional regulator C7M28_02617 ENOG4105CTX dehydratase C7M28_02620 ENOG4106UX7 integral membrane protein C7M28_02621 ENOG4105DPZ Two component transcriptional regulator (Winged helix family C7M28_02627 ENOG4105MUA Resistance protein C7M28_02628 ENOG4105DGI Alkaline phosphatase C7M28_02629 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) C7M28_02630 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) C7M28_02631 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) C7M28_02632 ENOG4107EPV Aminotransferase class V C7M28_02633 ENOG4105C0R drug resistance transporter emrb qaca subfamily C7M28_02634 ENOG4105J7D transcriptional regulator C7M28_02635 ENOG4107RB3 L-asparaginase C7M28_02636 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold C7M28_02638 ENOG41060AI SEC-C motif C7M28_02640 ENOG4107Y7X LytTR C7M28_02641 ENOG4108IUW ABC transporter C7M28_02642 ENOG4108SDH ABC, transporter C7M28_02643 ENOG4107SET aldo keto reductase C7M28_02644 ENOG4107SET aldo keto reductase C7M28_02650 ENOG4105H9W Short-chain dehydrogenase reductase Sdr C7M28_02652 ENOG4105DSE periplasmic solute binding protein C7M28_02653 ENOG4105DIK (ABC) transporter C7M28_02655 ENOG4105DEN Luciferase family C7M28_02656 ENOG4108N0M stress protein C7M28_02657 ENOG4106FN3 tellurium resistance protein C7M28_02658 ENOG4106FN3 tellurium resistance protein C7M28_02659 ENOG4107TS3 membrane protein, TerC C7M28_02660 ENOG4108TTB tellurium resistance protein C7M28_02662 ENOG41079KZ Major Facilitator Superfamily C7M28_02663 ENOG4107XZQ multidrug resistance protein C7M28_02664 ENOG4108A65 Transcriptional regulator C7M28_02665 ENOG4108IJ7 Glycine betaine C7M28_02666 ENOG4107SQ8 Glycine betaine C7M28_02672 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) C7M28_02679 ENOG4105EIG urea carboxylase-associated protein 1 C7M28_02680 ENOG4107RA1 nh(3)-dependent nad( ) synthetase C7M28_02681 ENOG4105I1F Resistance protein C7M28_02683 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) C7M28_02684 ENOG41089UC methyltransferase, type 11 C7M28_02685 ENOG4105C5Q Transcriptional regulator C7M28_02686 ENOG4105I82 acetyl xylan esterase C7M28_02687 ENOG410756H nucleotidyltransferase C7M28_02689 ENOG4105C26 Dehydrogenase C7M28_02690 ENOG4105CK7 Sodium proline symporter C7M28_02691 ENOG4107YHD transcriptional regulator C7M28_02693 ENOG4108PJD permease C7M28_02694 ENOG4105U6C Alpha beta hydrolase fold protein C7M28_02696 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C7M28_02697 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit C7M28_02698 ENOG4108IFG nitrite reductase, (NAD(P)H) C7M28_02699 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) C7M28_02703 ENOG4105S7A ErfK ybiS ycfS ynhG family protein C7M28_02704 ENOG4105CKI cobalamin synthesis protein C7M28_02705 ENOG4105E5Q amino acid AbC transporter C7M28_02706 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein C7M28_02709 ENOG4105HHM rdd domain containing protein C7M28_02711 ENOG4105CS2 ec 3.2.1.21 C7M28_02714 ENOG4105C8Q Methyl-accepting chemotaxis C7M28_02715 ENOG41080HJ 6-phospho 3-hexuloisomerase C7M28_02716 ENOG4108VA3 3-hexulose-6-phosphate synthase C7M28_02717 ENOG4105KVH Transcriptional regulator C7M28_02718 ENOG4105CEY Amp-dependent synthetase and ligase C7M28_02724 ENOG4105SX7 Transporter C7M28_02726 ENOG4105W8Z 4'-phosphopantetheinyl transferase C7M28_02728 ENOG4105CDA abc transporter atp-binding protein C7M28_02729 ENOG4105DRP amino acid AbC transporter C7M28_02731 ENOG4106P55 Transcriptional regulator C7M28_02732 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase C7M28_02733 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) C7M28_02734 ENOG41069ZX C7M28_02735 ENOG41069ZX C7M28_02737 ENOG4105DUX Transporter C7M28_02740 ENOG4105E1K spore germination protein C7M28_02744 ENOG4107WD8 ABC transporter, permease C7M28_02745 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C7M28_02746 ENOG4105BZU Histidine kinase C7M28_02750 ENOG4105CFH Aspartokinase C7M28_02751 ENOG4105DHS permease protein C7M28_02752 ENOG4105CM4 permease protein C7M28_02753 ENOG4108IPW abc transporter atp-binding protein C7M28_02756 ENOG4105R8C Transcriptional regulator C7M28_02757 ENOG4108DBC nitroreductase C7M28_02758 ENOG41067V3 Antibiotic biosynthesis monooxygenase C7M28_02759 ENOG4105YVS arsR family transcriptional regulator C7M28_02761 ENOG4108JPW Aminotransferase C7M28_02762 ENOG4105C26 Dehydrogenase C7M28_02764 ENOG4105H9W Short-chain dehydrogenase reductase Sdr C7M28_02765 ENOG4105KTB nuclear export factor GLE1 C7M28_02766 ENOG4108T5E Copper resistance protein C7M28_02767 ENOG4108ZYE Transcriptional regulator C7M28_02772 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) C7M28_02774 ENOG4108ZX0 Signal peptidase I C7M28_02779 ENOG4105E7W lamb ycsf family protein C7M28_02780 ENOG4105C5A transporter C7M28_02781 ENOG4105CFM UPF0317 protein C7M28_02782 ENOG4105P4J Allophanate hydrolase, subunit 1 C7M28_02784 ENOG4107258 Transcriptional regulator C7M28_02785 ENOG4105XJB lipolytic protein G-D-S-L family C7M28_02787 ENOG41061CK Antibiotic biosynthesis monooxygenase C7M28_02788 ENOG4107RVG penicillin-binding protein C7M28_02789 ENOG4107QM2 Aldo Keto reductase C7M28_02790 ENOG4105ETD TRANSCRIPTIONal C7M28_02792 ENOG4105HMZ Methyltransferase C7M28_02793 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C7M28_02796 ENOG410606W general stress protein C7M28_02798 ENOG4105VCH membrane C7M28_02800 ENOG4105C9U ATP-dependent DNA helicase RecQ C7M28_02803 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) C7M28_02804 ENOG4107R8N Glycosyl transferase, family 2 C7M28_02806 ENOG4105C0X amino acid C7M28_02810 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) C7M28_02812 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) C7M28_02813 ENOG4105EU9 C7M28_02814 ENOG4105QVS general stress protein C7M28_02815 ENOG41082W1 Cupin 2, conserved barrel domain protein C7M28_02818 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit C7M28_02819 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism C7M28_02820 ENOG4108MRH transcriptional regulatory protein C7M28_02821 ENOG4107QJT sodium dicarboxylate symporter C7M28_02822 ENOG4106F5Q Membrane C7M28_02823 ENOG4105CJ1 ABC, transporter C7M28_02826 ENOG4105FDT acyl-CoA dehydrogenase C7M28_02830 ENOG4105SZ6 Thioredoxin C7M28_02831 ENOG4105CPF Cell wall formation (By similarity) C7M28_02832 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) C7M28_02833 ENOG4105C1J atp-dependent rna helicase C7M28_02834 ENOG410905X membrane-flanked domain protein C7M28_02835 ENOG4105CKV Membrane C7M28_02837 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) C7M28_02838 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein C7M28_02839 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) C7M28_02841 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) C7M28_02842 ENOG4107MMM Anti-sigma-factor antagonist C7M28_02843 ENOG4105FUA antagonist C7M28_02844 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase C7M28_02845 ENOG4107SGM protein serine threonine phosphatase C7M28_02846 ENOG4105WN5 stage II sporulation protein C7M28_02847 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) C7M28_02849 ENOG41064BQ Phosphatase C7M28_02853 ENOG4105M5P UPF0310 protein C7M28_02854 ENOG4105RV9 Transcriptional regulator C7M28_02866 ENOG4106BHF C7M28_02867 ENOG4105VZ8 Transcriptional regulator C7M28_02872 ENOG4108V4B ThiJ pfpI C7M28_02873 ENOG4105VEQ Cold shock protein C7M28_02874 ENOG4108VJ1 Transcriptional regulator (CarD family C7M28_02876 ENOG4108MCI Transcriptional regulator, ARAC family C7M28_02877 ENOG4108UZ3 Transporter C7M28_02878 ENOG41086D8 Transcriptional regulator C7M28_02879 ENOG4107U9B transcriptional regulator C7M28_02880 ENOG4105DXI Major Facilitator superfamily C7M28_02882 ENOG4105CZ9 Domain of unknown function (DU1801) C7M28_02883 ENOG4105GIG C7M28_02885 ENOG4105KRI phosphocarrier protein (HPr C7M28_02886 ENOG4105ST3 Transcriptional regulator C7M28_02887 ENOG4105T38 integral membrane protein C7M28_02888 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C7M28_02889 ENOG4108ZMQ domain protein C7M28_02890 ENOG4105MJ9 esterase C7M28_02891 ENOG4107Z6X Transcriptional regulator C7M28_02893 ENOG4105KVH Transcriptional regulator C7M28_02894 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein C7M28_02895 ENOG4105EQ0 Major Facilitator superfamily C7M28_02896 ENOG4108JGH Tetr family transcriptional regulator C7M28_02897 ENOG41082YX Transcriptional regulator, arsr family C7M28_02898 ENOG4107R5R arsenical pump membrane protein C7M28_02899 ENOG4105Z7P Acetyltransferase (GNAT) family C7M28_02900 ENOG4107Y9U Membrane C7M28_02902 ENOG4108SQ9 flavin reductase domain protein, FMN-binding C7M28_02903 ENOG4108ZHR arsR family transcriptional regulator C7M28_02904 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) C7M28_02906 ENOG4105ENE Histidine kinase C7M28_02907 ENOG4108VB1 regulatoR C7M28_02908 ENOG4105EYF MMPL domain protein C7M28_02909 ENOG4108WC5 Alpha Beta Hydrolase Fold protein C7M28_02910 ENOG4108UQV Membrane C7M28_02911 ENOG4108Z5V transcriptional regulator, merr family C7M28_02912 ENOG41076HS cation diffusion facilitator family transporter C7M28_02913 ENOG4108TVJ Nitroreductase C7M28_02914 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase C7M28_02915 ENOG4108VGI doxx family C7M28_02916 ENOG4105XXY Thioredoxin C7M28_02920 ENOG410900G Protein of unknown function (DUF421) C7M28_02921 ENOG4108QY0 Membrane C7M28_02925 ENOG4105PF9 Transcriptional regulator C7M28_02927 ENOG4105WQG acetyltransferase C7M28_02928 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) C7M28_02929 ENOG4105ETE Transcriptional regulator (LacI family C7M28_02930 ENOG4105C54 Major Facilitator superfamily C7M28_02933 ENOG4105C85 amino acid C7M28_02935 ENOG41062A4 Transcriptional regulator C7M28_02936 ENOG4105EYF MMPL domain protein C7M28_02937 ENOG4108TVJ Nitroreductase C7M28_02938 ENOG4105FS7 Transcriptional regulator C7M28_02939 ENOG4105C2C drug resistance transporter, Bcr CflA C7M28_02941 ENOG4105DRR Transcriptional regulator, GntR family C7M28_02942 ENOG4105VRS hydrolase family 18 C7M28_02945 ENOG4105G6Z alkaline phosphatase C7M28_02946 ENOG4108ZMX Domain of unknown function (DU1801) C7M28_02948 ENOG4108YM7 Gcn5-related n-acetyltransferase C7M28_02949 ENOG4107TVP HD domain protein C7M28_02950 ENOG41090UD (LipO)protein C7M28_02951 ENOG4105F27 Major Facilitator C7M28_02952 ENOG4105VZJ PTS System C7M28_02953 ENOG4105VCP PTS System C7M28_02954 ENOG4105CK1 PTS System C7M28_02955 ENOG4105CS2 ec 3.2.1.21 C7M28_02956 ENOG4108TZY GntR Family Transcriptional Regulator C7M28_02957 ENOG4105EVU fructokinase C7M28_02958 ENOG4105DG6 mannose-6-phosphate isomerase C7M28_02959 ENOG4105D3P Mannan endo-1,4-beta-mannosidase C7M28_02968 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) C7M28_02969 ENOG4105K8N protein family UPF0079, ATPase C7M28_02970 ENOG41072GX Peptidase M22 Glycoprotease C7M28_02971 ENOG410801F ribosomal-protein-alanine acetyltransferase C7M28_02972 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) C7M28_02973 ENOG4105C5H ABC transporter C7M28_02974 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) C7M28_02975 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) C7M28_02976 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) C7M28_02977 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) C7M28_02979 ENOG4108TYN CAAX amino terminal protease family protein C7M28_02981 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) C7M28_02984 ENOG4105DVF Cytosine-specific methyltransferase C7M28_02985 ENOG4107RHI Cytosine-specific methyltransferase C7M28_02990 ENOG4105PGZ NB-ARC domain C7M28_02991 ENOG4105CPQ Dehydrogenase C7M28_02992 ENOG4105CT4 transporter C7M28_02994 ENOG41087YS Phage shock protein A C7M28_02995 ENOG4105DQX Zinc finger domain C7M28_02996 ENOG4108WV1 Pfam:DUF477 C7M28_02998 ENOG4108ZMR Ion transport 2 domain-containing protein C7M28_02999 ENOG4107QNK )-transporter C7M28_03005 ENOG4107YUH hydrolase C7M28_03007 ENOG4107STQ Multicopper oxidase C7M28_03008 ENOG4105C85 amino acid C7M28_03010 ENOG4105C7R Atpase associated with various cellular activities aaa_3 C7M28_03016 ENOG4105C7N Xanthine uracil vitamin C permease C7M28_03021 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) C7M28_03022 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit C7M28_03023 ENOG4105C83 adenylosuccinate lyase C7M28_03024 ENOG4105C8V SAICAR synthetase C7M28_03025 ENOG4105VR9 phosphoribosylformylglycinamidine synthase C7M28_03026 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I C7M28_03027 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii C7M28_03029 ENOG4105CXB phosphoribosylaminoimidazole synthetase C7M28_03030 ENOG4108V3E phosphoribosylglycinamide formyltransferase C7M28_03031 ENOG4105DC1 bifunctional purine biosynthesis protein purh C7M28_03032 ENOG4105C12 Phosphoribosylglycinamide synthetase C7M28_03034 ENOG4105DVH amino acid C7M28_03037 ENOG4108R5T secreted protein C7M28_03038 ENOG4105KGF protein, YerC YecD C7M28_03039 ENOG4105CBC glutamate synthase C7M28_03040 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) C7M28_03041 ENOG4105C4R Atp-dependent dna helicase C7M28_03042 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) C7M28_03044 ENOG4105CRN Aminoglycoside phosphotransferase C7M28_03045 ENOG4105KT7 mgtC SapB transporter C7M28_03046 ENOG4105CK7 Sodium proline symporter C7M28_03047 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C7M28_03048 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) C7M28_03049 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) C7M28_03050 ENOG4108IG5 Transcriptional regulator C7M28_03052 ENOG4105CBD Diacylglycerol kinase C7M28_03053 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C7M28_03064 ENOG4108HFV C7M28_03070 ENOG4105CDY transcriptional regulatory protein C7M28_03072 ENOG4105M4P Tetr family transcriptional regulator C7M28_03073 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein C7M28_03074 ENOG4107S9F NmrA family C7M28_03077 ENOG4105WEF catalase C7M28_03078 ENOG4105M18 -acetyltransferase C7M28_03080 ENOG4105C2F Histidine kinase C7M28_03081 ENOG4105EQD regulatoR C7M28_03082 ENOG410769Z extracellular solute-binding protein family 1 C7M28_03083 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component C7M28_03084 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component C7M28_03085 ENOG4105F5H Glycosyl Hydrolase Family 88 C7M28_03086 ENOG41075H3 AraC family transcriptional regulator C7M28_03087 ENOG4107TDE lipolytic protein G-D-S-L family C7M28_03090 ENOG4105CX8 fg-gap repeat protein C7M28_03091 ENOG4105CX8 fg-gap repeat protein C7M28_03092 ENOG4107TDE lipolytic protein G-D-S-L family C7M28_03094 ENOG4105EKC C7M28_03095 ENOG4105E0S extracellular solute-binding protein family 1 C7M28_03097 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component C7M28_03098 ENOG4105F8D glycoside hydrolase family 4 C7M28_03099 ENOG4105H67 Protein of unknown function (DUF421) C7M28_03100 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) C7M28_03101 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily C7M28_03105 ENOG4106I4J membrane C7M28_03106 ENOG41061H0 Monooxygenase C7M28_03107 ENOG4108R1P C7M28_03108 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) C7M28_03109 ENOG4105E0M Sulfatase C7M28_03110 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase C7M28_03112 ENOG41090R9 glycosyltransferase C7M28_03113 ENOG4107R51 Glycosyl transferase, family 2 C7M28_03114 ENOG41090R9 glycosyltransferase C7M28_03115 ENOG4105EU0 Major facilitator Superfamily C7M28_03117 ENOG4105CUB amino acid C7M28_03118 ENOG4105C26 Dehydrogenase C7M28_03119 ENOG4105FKZ Methyl-accepting chemotaxis C7M28_03120 ENOG4105C5H ABC transporter C7M28_03122 ENOG4107SWG transcriptional regulator MERR family C7M28_03123 ENOG4105DXB Major Facilitator superfamily C7M28_03124 ENOG4105C5H ABC transporter C7M28_03125 ENOG4105FDU atp-dependent rna helicase C7M28_03127 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein C7M28_03128 ENOG4105E0A ABC, transporter C7M28_03129 ENOG4108U1V ABC transporter, permease C7M28_03130 ENOG4105DQ5 transport system permease protein C7M28_03131 ENOG4108HUF Transporter C7M28_03134 ENOG4108J20 pectate lyase C7M28_03135 ENOG4107QPK )-transporter C7M28_03137 ENOG4108MRH transcriptional regulatory protein C7M28_03142 ENOG410855V Acylphosphatase C7M28_03143 ENOG4108RPX mosc domain containing protein C7M28_03147 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) C7M28_03152 ENOG4105E1K spore germination protein C7M28_03153 ENOG4105C5Y PTS System C7M28_03154 ENOG4105CG3 alpha amylase, catalytic region C7M28_03155 ENOG4107414 GntR family transcriptional regulator C7M28_03156 ENOG4108RCM Nitroreductase C7M28_03157 ENOG4105CGH 5'-nucleotidase C7M28_03158 ENOG4107RKG DJ-1/PfpI family C7M28_03161 ENOG4105KJF protein tyrosine phosphatase C7M28_03163 ENOG4107U9T Pfam:Ribonuclease_BN C7M28_03165 ENOG4108ISG Major Facilitator C7M28_03166 ENOG4105UPD Calcium Proton C7M28_03168 ENOG4105D8X mechanosensitive ion channel C7M28_03172 ENOG4106KE4 Dehydrogenase C7M28_03173 ENOG4105D7N magnesium and cobalt transport protein CorA C7M28_03175 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) C7M28_03179 ENOG4107RUY (E1 component), alpha subunit C7M28_03181 ENOG4107QKR Dehydrogenase C7M28_03183 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family C7M28_03184 ENOG41069DP small acid-soluble spore protein C7M28_03185 ENOG4105KK4 UPF0060 membrane protein C7M28_03191 ENOG4105F8D glycoside hydrolase family 4 C7M28_03192 ENOG4108Q3X Transcriptional regulator C7M28_03193 ENOG4105CI1 PTS System C7M28_03194 ENOG4105BZ1 (ABC) transporter C7M28_03195 ENOG4105BZ1 (ABC) transporter C7M28_03197 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase C7M28_03198 ENOG4105ID8 Transcriptional regulator, ARAC family C7M28_03199 ENOG4107QNK )-transporter C7M28_03200 ENOG4107QP6 Xylose isomerase domain protein TIM barrel C7M28_03201 ENOG4105CIB oxidoreductase Domain protein C7M28_03203 ENOG4105BZU Histidine kinase C7M28_03204 ENOG4105WH1 Two component transcriptional regulator luxr family C7M28_03205 ENOG4105CJ1 ABC, transporter C7M28_03206 ENOG41090VJ ABC-2 type transporter C7M28_03207 ENOG4108KYE ABC-2 type transporter C7M28_03208 ENOG4105U3E Transcriptional regulator C7M28_03209 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold C7M28_03210 ENOG4105H93 Acyltransferase family C7M28_03211 ENOG4105YA8 Transcriptional regulator C7M28_03212 ENOG4107Y80 Major Facilitator superfamily C7M28_03213 ENOG4108YYS metal-dependent hydrolase (By similarity) C7M28_03214 ENOG4105C0R drug resistance transporter emrb qaca subfamily C7M28_03215 ENOG410834F Transcriptional regulator C7M28_03217 ENOG4108MES Periplasmic binding protein C7M28_03218 ENOG4105DQ5 transport system permease protein C7M28_03219 ENOG4108IHU transport system permease protein C7M28_03220 ENOG4105JAB phenazine biosynthesis protein, phzf family C7M28_03221 ENOG4107Y03 Nitroreductase C7M28_03224 ENOG4105ECP epimerase C7M28_03228 ENOG4105F27 Major Facilitator C7M28_03232 ENOG4106AKJ C7M28_03233 ENOG4105D74 hydrolase C7M28_03234 ENOG4105CKK Glycosyl transferase, family 2 C7M28_03235 ENOG4105EJV Membrane C7M28_03236 ENOG41067AE Membrane-bound metal-dependent hydrolase C7M28_03237 ENOG4105CEN a g-specific adenine glycosylase C7M28_03238 ENOG4106BXE C7M28_03239 ENOG4105CAN Short-chain dehydrogenase reductase Sdr C7M28_03242 ENOG4105EVI UPF0374 protein C7M28_03243 ENOG4105BZ1 (ABC) transporter C7M28_03244 ENOG4107NBY Membrane C7M28_03246 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C7M28_03247 ENOG4105G5W regulator Fur family C7M28_03269 ENOG4108N23 SpoOM-related protein C7M28_03271 ENOG4105EC3 peptidase S51, dipeptidase E C7M28_03272 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) C7M28_03273 ENOG4105DNP FAD linked oxidase domain protein C7M28_03276 ENOG4105E2Y ABC, transporter C7M28_03277 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein C7M28_03278 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component C7M28_03279 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) C7M28_03281 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) C7M28_03282 ENOG4107D63 C7M28_03283 ENOG4105VZ8 Transcriptional regulator C7M28_03286 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) C7M28_03288 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) C7M28_03292 ENOG4105CYN Serine protein kinase C7M28_03293 ENOG4106AKX UPF0229 protein C7M28_03294 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes C7M28_03295 ENOG4105CW7 secretion protein, HlyD family C7M28_03296 ENOG4105C0R drug resistance transporter emrb qaca subfamily C7M28_03297 ENOG4105CS1 NAD(P)H quinone oxidoreductase C7M28_03300 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family C7M28_03301 ENOG4105CZV ABC transporter C7M28_03302 ENOG4105CJ1 ABC, transporter C7M28_03303 ENOG4108TU7 Inherit from COG: (ABC) transporter C7M28_03304 ENOG4105VEQ Cold shock protein C7M28_03306 ENOG4105BZU Histidine kinase C7M28_03316 ENOG4108YBP pseudouridine synthase C7M28_03318 ENOG41080XP Cbs domain C7M28_03319 ENOG4107YBY Hydrolase C7M28_03320 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase C7M28_03321 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) C7M28_03322 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator C7M28_03324 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) C7M28_03325 ENOG4105C6V Glycerol-3-phosphate dehydrogenase C7M28_03327 ENOG4105BZU Histidine kinase C7M28_03328 ENOG4105WH1 Two component transcriptional regulator luxr family C7M28_03335 ENOG4105ED1 spovr family C7M28_03336 ENOG4105G6Z alkaline phosphatase C7M28_03339 ENOG4105BZN citrate synthase C7M28_03340 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C7M28_03341 ENOG4105CUB amino acid C7M28_03342 ENOG4105C8J )-transporter C7M28_03343 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C7M28_03346 ENOG4105J37 C7M28_03347 ENOG4108AEY RNA polymerase sigma factor C7M28_03348 ENOG4108FN7 Aldo keto reductase C7M28_03349 ENOG4105F6E Acyl-transferase C7M28_03350 ENOG4105C37 (CBS) domain C7M28_03352 ENOG4105CHM Aminotransferase C7M28_03353 ENOG4105C37 (CBS) domain C7M28_03355 ENOG4105WMR Protein CrcB homolog C7M28_03356 ENOG4108QXE glycerophosphoryl diester phosphodiesterase C7M28_03358 ENOG4105D64 Mechanosensitive ion channel C7M28_03359 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) C7M28_03360 ENOG4107VMI polysaccharide deacetylase C7M28_03361 ENOG4105F0I Aminotransferase C7M28_03364 ENOG4105BZ1 (ABC) transporter C7M28_03365 ENOG4105BZ1 (ABC) transporter C7M28_03369 ENOG410839P C7M28_03371 ENOG4106MP8 UPF0754 membrane protein C7M28_03372 ENOG4105WZB UPF0342 protein C7M28_03373 ENOG4105F1N DNA alkylation repair C7M28_03375 ENOG4105D4P Coproporphyrinogen iii oxidase C7M28_03376 ENOG4107S91 Sodium hydrogen exchanger C7M28_03377 ENOG4105NCW Trka-c domain protein C7M28_03379 ENOG4105CGU Enoyl-CoA hydratase C7M28_03381 ENOG4108IUX (ABC) transporter C7M28_03382 ENOG4105RHA ABC transporter, permease C7M28_03383 ENOG4107VRP DNA repair exonuclease C7M28_03384 ENOG4106D4I domain protein C7M28_03385 ENOG4105EQI Metal Dependent Phosphohydrolase C7M28_03387 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) C7M28_03392 ENOG4105NBU tryptophan transport protein C7M28_03393 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) C7M28_03394 ENOG4105K59 histidine triad (HIT) protein C7M28_03401 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation C7M28_03402 ENOG4105BZ4 penicillin-binding protein C7M28_03403 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) C7M28_03404 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) C7M28_03405 ENOG4105C1Q protoporphyrinogen oxidase C7M28_03407 ENOG4105ECB domain protein C7M28_03409 ENOG41090T1 Membrane C7M28_03410 ENOG4105DER m42 family C7M28_03413 ENOG4108RQ5 Beta-lactamase domain-containing protein C7M28_03414 ENOG4105DF9 Lipoate-protein, ligase C7M28_03416 ENOG4105CEY Amp-dependent synthetase and ligase C7M28_03418 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 C7M28_03419 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C7M28_03420 ENOG4105KD7 acetyltransferase C7M28_03422 ENOG4108HUF Transporter C7M28_03423 ENOG4107TB6 phosphoglycerate mutase C7M28_03425 ENOG4107F3J Amp-dependent synthetase and ligase C7M28_03426 ENOG4107ZYJ bioY protein C7M28_03427 ENOG4106YBV Methyl-accepting chemotaxis C7M28_03431 ENOG4105XVF Competence transcription factor C7M28_03432 ENOG4105CYX Short-chain dehydrogenase reductase Sdr C7M28_03433 ENOG4105X3H Excalibur domain protein C7M28_03434 ENOG4105E1V na solute symporter C7M28_03435 ENOG4106CAD Protein of unknown function (DUF3311) C7M28_03436 ENOG41060YP C7M28_03439 ENOG4107SCK Monooxygenase C7M28_03440 ENOG4108INS Transcriptional regulator C7M28_03443 ENOG4105TRI Hydrolase C7M28_03446 ENOG4108KK1 membrane protein AbrB duplication C7M28_03447 ENOG4106K7D Major facilitator family transporter C7M28_03448 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) C7M28_03449 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding C7M28_03452 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation C7M28_03454 ENOG4105EYH Exonuclease C7M28_03464 ENOG4105ERH Fumarylacetoacetate hydrolase C7M28_03466 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C7M28_03468 ENOG4105CAQ asparagine synthetase C7M28_03471 ENOG4105UQX Mate efflux family protein C7M28_03472 ENOG4106HBX Transcriptional Regulator AraC Family C7M28_03473 ENOG4105ETE Transcriptional regulator (LacI family C7M28_03474 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) C7M28_03475 ENOG4105SF0 DinB family C7M28_03476 ENOG4108ZUB Lysine exporter protein (Lyse ygga) C7M28_03477 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family C7M28_03478 ENOG4105MYW Pentapeptide repeat protein C7M28_03479 ENOG4107S9D Alpha beta hydrolase C7M28_03480 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) C7M28_03481 ENOG4107RIQ Sulfate adenylate transferase C7M28_03482 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) C7M28_03483 ENOG4108N5B 2-phosphosulfolactate phosphatase C7M28_03484 ENOG41061P3 phosphosulfolactate synthase C7M28_03486 ENOG4105DIA mandelate racemase muconate lactonizing C7M28_03487 ENOG4107RCC Major Facilitator Superfamily C7M28_03488 ENOG4108SZE gCN5-related N-acetyltransferase C7M28_03489 ENOG4105MA6 gCN5-related N-acetyltransferase C7M28_03491 ENOG4108VPT UPF0234 protein C7M28_03492 ENOG4105QNR S1 RNA binding domain protein C7M28_03496 ENOG4105K7K Transcriptional regulator C7M28_03498 ENOG410751J C7M28_03499 ENOG4105D4Y metalloprotease C7M28_03500 ENOG4105EPR degv family C7M28_03501 ENOG4107AYK membrAne C7M28_03503 ENOG41073B9 C7M28_03504 ENOG4108KP7 hydrolase C7M28_03505 ENOG4108MXZ Esterase C7M28_03506 ENOG4105VG1 fes assembly suf system protein C7M28_03508 ENOG4105IQ5 FAD linked oxidase domain protein C7M28_03510 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase C7M28_03511 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) C7M28_03513 ENOG4105C8Y Acetylornithine aminotransferase C7M28_03514 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain C7M28_03516 ENOG4105DBV ornithine carbamoyltransferase C7M28_03521 ENOG4107RMD Basic membrane lipoprotein C7M28_03524 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) C7M28_03525 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) C7M28_03527 ENOG4105C3U ABC transporter C7M28_03528 ENOG4108JQ7 (ABC) transporter C7M28_03531 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C7M28_03533 ENOG4105C31 Tryptophanyl-tRNA synthetase C7M28_03534 ENOG4108J59 Extracellular solute-binding protein, family 5 C7M28_03535 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C7M28_03536 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C7M28_03538 ENOG4108JQ7 (ABC) transporter C7M28_03541 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) C7M28_03542 ENOG4108ZCF integral membrane protein C7M28_03543 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis C7M28_03545 ENOG4105DPN Oligoendopeptidase f C7M28_03548 ENOG4105T58 Dithiol-disulfide isomerase C7M28_03549 ENOG4108Z18 K06886 hemoglobin C7M28_03550 ENOG4105E4C Lytic transglycosylase catalytic C7M28_03551 ENOG4105MIX Adenylate cyclase C7M28_03554 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) C7M28_03555 ENOG4105EMS pseudouridine synthase C7M28_03558 ENOG4105ETU transcriptional activator (TenA C7M28_03559 ENOG4108VEU Thiamine monophosphate synthase C7M28_03562 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) C7M28_03563 ENOG4105D06 uba thif-type nad fad binding protein C7M28_03564 ENOG4105DWF phosphomethylpyrimidine kinase C7M28_03565 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH C7M28_03566 ENOG4107A88 C7M28_03576 ENOG4105ENA helicase C7M28_03579 ENOG4108ZMI UPF0477 protein C7M28_03581 ENOG4105C28 cystathionine C7M28_03582 ENOG4105C28 cystathionine C7M28_03583 ENOG4105D9U N-acetyltransferase C7M28_03584 ENOG4105JHY Membrane C7M28_03587 ENOG41068SY C7M28_03591 ENOG4107KNS C7M28_03596 ENOG4108PSK reductase C7M28_03599 ENOG4105DM4 PTS System C7M28_03600 ENOG4105DG6 mannose-6-phosphate isomerase C7M28_03601 ENOG4105G7B Protein of unknown function (DUF2992) C7M28_03602 ENOG4105VMI -acetyltransferase C7M28_03604 ENOG4108Z66 YbaK ebsC protein C7M28_03607 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) C7M28_03609 ENOG4108ZJ4 polysaccharide deacetylase C7M28_03610 ENOG4107CUJ Protein of unknown function (DUF2690) C7M28_03615 ENOG4108IEG Formate dehydrogenase Alpha subunit C7M28_03620 ENOG4106A3M Cytochrome p-450 C7M28_03621 ENOG41087PP glycosyltransferase MGT family C7M28_03623 ENOG4105EXQ uroporphyrinogen iii synthase hem4 C7M28_03624 ENOG4105C4B ABC transporter, permease C7M28_03625 ENOG4108IXI (ABC) transporter C7M28_03627 ENOG4105Q95 Cupin 2, conserved barrel domain protein C7M28_03630 ENOG4105D2H Uronic isomerase C7M28_03631 ENOG4105CT4 transporter C7M28_03632 ENOG4105DG4 malate L-lactate dehydrogenase C7M28_03633 ENOG4105CPQ Dehydrogenase C7M28_03634 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) C7M28_03635 ENOG4105DMW Dehydrogenase reductase C7M28_03636 ENOG4108I5G Major Facilitator superfamily C7M28_03637 ENOG4107KJX Transcriptional regulator C7M28_03638 ENOG4107QZW Altronate oxidoreductase C7M28_03639 ENOG4105CTX dehydratase C7M28_03640 ENOG4107TSN permease C7M28_03642 ENOG4105JD4 ATPase yjob C7M28_03645 ENOG41068K0 YCII-related domain C7M28_03646 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase C7M28_03647 ENOG4105KWG Pfam:DUF1696 C7M28_03648 ENOG4105K7W phage-related replication protein C7M28_03649 ENOG4105WEF catalase C7M28_03650 ENOG410635T phage-like element pbsx protein C7M28_03659 ENOG4108TFU terminase (Small subunit) C7M28_03660 ENOG4105IG6 Phage terminase, large subunit C7M28_03661 ENOG4108MDF Phage Portal Protein C7M28_03666 ENOG41060SN C7M28_03668 ENOG4105PQS phage protein C7M28_03669 ENOG4105FR7 XkdM protein, phage-like element PBSX C7M28_03670 ENOG4105MTC XkdN-like protein C7M28_03671 ENOG4108FKH Transglycosylase SLT domain C7M28_03672 ENOG4108WZM domain protein C7M28_03673 ENOG4105X7F C7M28_03675 ENOG4105MFU Protein of unknown function (DUF2634) C7M28_03676 ENOG41066EA baseplate J family protein C7M28_03677 ENOG410906S phage-like element pbsx protein xkdt C7M28_03679 ENOG41068G1 C7M28_03685 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase C7M28_03688 ENOG4105CJ3 phosphate transporter C7M28_03689 ENOG4107GRR phosphate transport regulator C7M28_03690 ENOG4107R7I amino acid C7M28_03692 ENOG4105EDW glycosyl transferase, family 39 C7M28_03693 ENOG4105CKK Glycosyl transferase, family 2 C7M28_03695 ENOG4105C0H protease C7M28_03697 ENOG4108ME1 Peptidase M55 D-aminopeptidase C7M28_03698 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component C7M28_03699 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component C7M28_03700 ENOG4105C3U ABC transporter C7M28_03703 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A C7M28_03704 ENOG4105DTQ mandelate racemase muconate lactonizing C7M28_03705 ENOG4107SN7 NLP P60 protein C7M28_03706 ENOG4108JQ7 (ABC) transporter C7M28_03707 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) C7M28_03708 ENOG4107TUM Amidinotransferase C7M28_03709 ENOG4108S4H thioesterase Superfamily protein C7M28_03710 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) C7M28_03714 ENOG4108428 Inherit from COG: -acetyltransferase C7M28_03716 ENOG41080TC multidrug resistance protein C7M28_03717 ENOG4105CIY formyltetrahydrofolate deformylase C7M28_03718 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) C7M28_03721 ENOG4105K56 Transcriptional regulator C7M28_03722 ENOG4108ZHJ Organic hydroperoxide resistance protein C7M28_03723 ENOG4107Y2X deaminase C7M28_03724 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) C7M28_03725 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C7M28_03727 ENOG4108W7F transporter, permease C7M28_03728 ENOG4108JJB ABC transporter C7M28_03729 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein C7M28_03730 ENOG4108X43 YKOF domain protein C7M28_03731 ENOG4105CK6 Two component transcriptional regulator (Winged helix family C7M28_03732 ENOG41062D9 Histidine kinase C7M28_03734 ENOG4106849 propeptide, pepSY amd peptidase M4 C7M28_03737 ENOG4105CJW magnesium transporter C7M28_03738 ENOG4105V75 Transcriptional regulator C7M28_03747 ENOG4105DQE DNA ligase C7M28_03748 ENOG4105FDF Could be involved in DNA repair (By similarity) C7M28_03749 ENOG4105BZU Histidine kinase C7M28_03750 ENOG4107T5V SNARE associated Golgi C7M28_03751 ENOG4107TS3 membrane protein, TerC C7M28_03752 ENOG4108WZW RNA polymerase sigma C7M28_03754 ENOG410681C small acid-soluble spore protein C7M28_03756 ENOG4105D0M Protease HtpX homolog C7M28_03760 ENOG4108TGC Acyltransferase C7M28_03761 ENOG4105BZU Histidine kinase C7M28_03762 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) C7M28_03764 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) C7M28_03765 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) C7M28_03766 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase C7M28_03768 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit C7M28_03769 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) C7M28_03770 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) C7M28_03771 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) C7M28_03775 ENOG4105BZU Histidine kinase C7M28_03776 ENOG41090MY MarR family Transcriptional regulator C7M28_03777 ENOG4105ER2 Ompa motb domain protein C7M28_03778 ENOG4105E14 MotA TolQ exbB proton channel C7M28_03780 ENOG4108K88 Membrane C7M28_03781 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) C7M28_03782 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase C7M28_03783 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) C7M28_03784 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) C7M28_03786 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr C7M28_03787 ENOG4105FEA Spore maturation protein C7M28_03793 ENOG4105F0V Cell wall hydrolase C7M28_03796 ENOG4105C59 p-type ATPase C7M28_03798 ENOG4105DC7 peptidase M24 C7M28_03801 ENOG4105CID antiterminator C7M28_03803 ENOG4105KRI phosphocarrier protein (HPr C7M28_03804 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) C7M28_03806 ENOG4105F6S Spore photoproduct lyase C7M28_03808 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer C7M28_03809 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase C7M28_03810 ENOG4105K4I Scp-like extracellular C7M28_03812 ENOG4105BZU Histidine kinase C7M28_03813 ENOG4105CHM Aminotransferase C7M28_03815 ENOG4107R88 Chemotaxis protein (CheV) C7M28_03816 ENOG4105UIN C7M28_03818 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein C7M28_03820 ENOG4105K6S Short-chain dehydrogenase reductase Sdr C7M28_03821 ENOG4105EPM Diguanylate phosphodiesterase C7M28_03822 ENOG4107IN1 Protein of unknown function (DUF1797) C7M28_03823 ENOG4108XRC Protein of unknown function (DUF458) C7M28_03829 ENOG4105NQC Flavodoxin C7M28_03831 ENOG4105CH2 amidohydrolase C7M28_03833 ENOG4105D8X mechanosensitive ion channel C7M28_03834 ENOG4105D3R alkyl hydroperoxide reductase C7M28_03835 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen C7M28_03838 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) C7M28_03839 ENOG4105D06 uba thif-type nad fad binding protein C7M28_03840 ENOG4105CVM Molybdenum cofactor synthesis domain protein C7M28_03841 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein C7M28_03842 ENOG4108ZAF Molybdopterin C7M28_03843 ENOG41067WU Molybdopterin converting factor (Subunit 1) C7M28_03844 ENOG4105BZ1 (ABC) transporter C7M28_03845 ENOG4105BZ1 (ABC) transporter C7M28_03847 ENOG4107X8C Efflux transporter RND family MFP subunit C7M28_03848 ENOG4105C19 ABC transporter C7M28_03849 ENOG4107RBB ABC transporter, permease C7M28_03850 ENOG4105E98 transcriptional regulator DeoR family C7M28_03851 ENOG4105DE4 1-phosphofructokinase C7M28_03852 ENOG4105DM4 PTS System C7M28_03853 ENOG4105C3F Signal peptidase i C7M28_03855 ENOG4105C5H ABC transporter C7M28_03856 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) C7M28_03861 ENOG4105BZU Histidine kinase C7M28_03863 ENOG4107ZYR domain protein C7M28_03865 ENOG4105CN5 Metallo-Beta-Lactamase C7M28_03867 ENOG4108X4Q Hydrolase C7M28_03868 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C7M28_03872 ENOG4105CPP Dehydrogenase, E1 component C7M28_03873 ENOG4105C7S Dehydrogenase C7M28_03874 ENOG4107QN2 dihydrolipoyl dehydrogenase C7M28_03876 ENOG4105CXN decarboxylase C7M28_03877 ENOG4105WBI UPF0223 protein C7M28_03880 ENOG4105ECY inositol monophosphatase C7M28_03882 ENOG4105JQZ Methyltransferase C7M28_03890 ENOG4105CI3 gtp-binding protein typa C7M28_03891 ENOG4105QA2 C7M28_03894 ENOG4108IAB Phoh family C7M28_03896 ENOG4105CSV Glutaminase C7M28_03897 ENOG4105ZPI UPF0358 protein C7M28_03898 ENOG4105CNI cell division protein FtsW C7M28_03899 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) C7M28_03901 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) C7M28_03903 ENOG4105BZ9 Cytochrome C oxidase, subunit I C7M28_03904 ENOG4105CCU oxidase (Subunit III) C7M28_03905 ENOG41064X9 cytochrome C oxidase subunit IV C7M28_03908 ENOG41080XQ Signal transduction protein with cbs domains C7M28_03909 ENOG4106UY4 Inherit from COG: Scp-like extracellular C7M28_03913 ENOG4105WUC UPF0298 protein C7M28_03914 ENOG4106H78 methyltransferase C7M28_03915 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) C7M28_03916 ENOG4105H20 Sporulation integral membrane protein YlbJ C7M28_03917 ENOG4105D78 K07001 NTE family protein C7M28_03918 ENOG41063PX domain protein C7M28_03919 ENOG4105CDE UPF0348 protein C7M28_03921 ENOG4105KNH Nucleic acid-binding protein C7M28_03927 ENOG4108V6E Cell division protein mraZ C7M28_03928 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) C7M28_03930 ENOG4105CJN penicillin-binding protein C7M28_03931 ENOG4105CJN penicillin-binding protein C7M28_03932 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) C7M28_03933 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) C7M28_03934 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) C7M28_03935 ENOG4105CNI cell division protein FtsW C7M28_03936 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) C7M28_03937 ENOG4105D4A Cell wall formation (By similarity) C7M28_03938 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) C7M28_03939 ENOG4108R2U division initiation protein C7M28_03941 ENOG4105K67 small basic protein C7M28_03942 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) C7M28_03943 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) C7M28_03945 ENOG4105FFI sigma-e processing peptidase spoiiga C7M28_03946 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C7M28_03948 ENOG4105DKW ABC transporter C7M28_03950 ENOG4105WR5 sporulation protein, YlmC YmxH family C7M28_03951 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase C7M28_03952 ENOG4105DFA alanine racemase domain protein C7M28_03953 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) C7M28_03954 ENOG41067XK integral membrane protein C7M28_03955 ENOG4105DBK s4 domain protein C7M28_03957 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) C7M28_03959 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) C7M28_03960 ENOG4105C34 Pseudouridine synthase C7M28_03961 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) C7M28_03963 ENOG4105CXT aspartate transcarbamylase C7M28_03965 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain C7M28_03966 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain C7M28_03967 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) C7M28_03968 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) C7M28_03969 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) C7M28_03970 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) C7M28_03972 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) C7M28_03974 ENOG4107S4M Sulfate adenylate transferase C7M28_03975 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) C7M28_03976 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) C7M28_03977 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein C7M28_03978 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein C7M28_03981 ENOG4105DSJ YicC domain protein C7M28_03982 ENOG4105KC4 UPF0296 protein C7M28_03983 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) C7M28_03985 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase C7M28_03986 ENOG4105C25 Primosomal protein n' C7M28_03987 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) C7M28_03988 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) C7M28_03989 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B C7M28_03990 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs C7M28_03991 ENOG4108ZF3 Phosphatase C7M28_03992 ENOG4105D9P serine threonine protein kinase C7M28_03993 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) C7M28_03994 ENOG4105DJV ribulose-phosphate 3-epimerase C7M28_03995 ENOG4105FJ0 thiamine C7M28_03996 ENOG4105VB9 50S ribosomal protein l28 C7M28_03997 ENOG4108ZAA Alkaline-shock protein C7M28_03998 ENOG4105DP4 dak2 domain fusion protein ylov C7M28_04000 ENOG4105EJQ L-serine dehydratase C7M28_04001 ENOG4105CB5 ATP-dependent DNA helicase recG C7M28_04002 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) C7M28_04004 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C7M28_04005 ENOG4105CHR reductase C7M28_04007 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) C7M28_04008 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) C7M28_04009 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) C7M28_04011 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) C7M28_04013 ENOG4105K5M 30s ribosomal protein S16 C7M28_04014 ENOG4108BW8 UPF0109 protein C7M28_04016 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) C7M28_04017 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) C7M28_04018 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) C7M28_04019 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) C7M28_04020 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C7M28_04022 ENOG4105VM1 flagellar C7M28_04023 ENOG4105CMV Succinyl-CoA synthetase subunit beta C7M28_04024 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha C7M28_04025 ENOG4105C79 DNA protecting protein DprA C7M28_04026 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) C7M28_04027 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) C7M28_04028 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) C7M28_04029 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) C7M28_04030 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) C7M28_04032 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) C7M28_04033 ENOG4108ZC9 flagellar basal-body rod protein flgc C7M28_04034 ENOG4105VQ0 flagellar hook-basal body complex protein fliE C7M28_04035 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) C7M28_04036 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C7M28_04039 ENOG4106YF4 Flagellar biosynthesis chaperone C7M28_04041 ENOG410696Y Flagellar hook-length control protein C7M28_04042 ENOG410822I Flagellar hook capping protein C7M28_04043 ENOG4108JQA flagellar C7M28_04045 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) C7M28_04046 ENOG4105DD5 Flagellar motor switch protein C7M28_04047 ENOG4107YTP response regulator receiver protein C7M28_04049 ENOG4105CN7 Flagellar biosynthetic protein FliP C7M28_04050 ENOG4105VS8 Flagellar biosynthetic protein fliq C7M28_04051 ENOG4105D19 Role in flagellar biosynthesis (By similarity) C7M28_04052 ENOG4105D00 flagellar biosynthetic protein flhB C7M28_04053 ENOG4105D7B Flagellar biosynthesis protein flha C7M28_04054 ENOG4105FZW flagellar biosynthesis regulator FlhF C7M28_04056 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) C7M28_04057 ENOG4105CBS Chea signal transduction histidine kinase C7M28_04058 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis C7M28_04061 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) C7M28_04063 ENOG4105CE9 30S ribosomal protein S2 C7M28_04064 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) C7M28_04066 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) C7M28_04067 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) C7M28_04068 ENOG4105KNE Phosphatidate cytidylyltransferase C7M28_04070 ENOG4105DZP Membrane-associated zinc metalloprotease C7M28_04071 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) C7M28_04072 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) C7M28_04073 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) C7M28_04074 ENOG4105CHV Transcription elongation factor NusA C7M28_04075 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination C7M28_04076 ENOG4105VHM ribosomal protein C7M28_04077 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) C7M28_04078 ENOG4105W7A Protein of unknown function (DUF503) C7M28_04079 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) C7M28_04080 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) C7M28_04081 ENOG4105DTN riboflavin biosynthesis protein ribF C7M28_04082 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) C7M28_04083 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) C7M28_04085 ENOG4105C1V Peptidase, M16 C7M28_04087 ENOG4105E35 Dipicolinate synthase subunit A C7M28_04088 ENOG4108S0H Dipicolinic acid synthetase, b subunit C7M28_04089 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) C7M28_04091 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) C7M28_04093 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit C7M28_04095 ENOG4105CNU cell division protein FtsK C7M28_04096 ENOG4105FDP GntR family transcriptional regulator C7M28_04100 ENOG4108RKS Short-chain dehydrogenase reductase Sdr C7M28_04101 ENOG4105XZV Protein of unknown function (DUF3243) C7M28_04104 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase C7M28_04105 ENOG4105CEV competence damage-inducible protein C7M28_04107 ENOG4108A04 Beta-lactamase C7M28_04108 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) C7M28_04109 ENOG4105D48 metallophosphoesterase C7M28_04110 ENOG4105MCT stage V sporulation protein S C7M28_04112 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) C7M28_04113 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) C7M28_04116 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) C7M28_04117 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) C7M28_04120 ENOG4105IIP Membrane C7M28_04121 ENOG4105W1N transcriptional regulator C7M28_04122 ENOG4108151 Beta-lactamase domain protein C7M28_04123 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase C7M28_04125 ENOG4107QKG PfaD family C7M28_04126 ENOG41062T2 Acyl carrier protein C7M28_04127 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase C7M28_04128 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase C7M28_04129 ENOG4108MGH Enoyl-CoA hydratase C7M28_04130 ENOG4108KQ6 Enoyl-CoA hydratase C7M28_04131 ENOG4105C0W non-ribosomal peptide synthetase C7M28_04132 ENOG4107SQU synthase C7M28_04134 ENOG4105C0W non-ribosomal peptide synthetase C7M28_04136 ENOG4106A3M Cytochrome p-450 C7M28_04139 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin C7M28_04158 ENOG4108FKH Transglycosylase SLT domain C7M28_04180 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C7M28_04181 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) C7M28_04191 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) C7M28_04195 ENOG4106J9J DNA polymerase C7M28_04199 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) C7M28_04214 ENOG4105NQC Flavodoxin C7M28_04215 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C7M28_04216 ENOG4107QYD Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) C7M28_04217 ENOG41088HM C7M28_04234 ENOG41069ER domain protein