locus-tag	class	description
ES969_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ES969_00010	COG0592	DNA-directed DNA polymerase activity
ES969_00015	COG2501	S4 domain
ES969_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ES969_00030	COG0187	DNA topoisomerase II activity
ES969_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ES969_00070	COG0517	IMP dehydrogenase activity
ES969_00070	COG0516	GMP reductase activity
ES969_00075	COG1686	Belongs to the peptidase S11 family
ES969_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ES969_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ES969_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ES969_00100	COG1428	Deoxynucleoside kinase
ES969_00105	COG1428	Deoxynucleoside kinase
ES969_00110	COG1388	LysM domain
ES969_00110	COG3858	chitin binding
ES969_00120	COG0590	tRNA wobble adenosine to inosine editing
ES969_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ES969_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ES969_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ES969_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
ES969_00190	COG3853	Toxic anion resistance protein (TelA)
ES969_00195	COG1982	Orn Lys Arg decarboxylase major
ES969_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ES969_00205	COG3870	Protein conserved in bacteria
ES969_00210	COG1728	Protein conserved in bacteria
ES969_00215	COG0470	DNA polymerase III
ES969_00220	COG1774	PSP1 C-terminal conserved region
ES969_00225	COG4467	Involved in initiation control of chromosome replication
ES969_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ES969_00235	COG2827	Endonuclease containing a URI domain
ES969_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ES969_00255	COG2002	toxin-antitoxin pair type II binding
ES969_00260	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES969_00260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES969_00265	COG0084	hydrolase, TatD family'
ES969_00270	COG3584	3D domain protein
ES969_00270	COG3583	domain protein
ES969_00275	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ES969_00280	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ES969_00290	COG4466	Protein conserved in bacteria
ES969_00300	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ES969_00305	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ES969_00310	COG0251	oxidation-reduction process
ES969_00315	COG2088	sporulation resulting in formation of a cellular spore
ES969_00320	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ES969_00325	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ES969_00330	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ES969_00335	COG0193	aminoacyl-tRNA hydrolase activity
ES969_00345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ES969_00350	COG2002	toxin-antitoxin pair type II binding
ES969_00355	COG2244	polysaccharide biosynthetic process
ES969_00360	COG3956	TIGRFAM MazG family protein
ES969_00365	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ES969_00380	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ES969_00385	COG1098	S1 RNA binding domain
ES969_00400	COG2208	phosphoserine phosphatase activity
ES969_00405	COG2304	oxidoreductase activity
ES969_00410	COG0515	serine threonine protein kinase
ES969_00415	COG0037	tRNA processing
ES969_00425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ES969_00430	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ES969_00435	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ES969_00440	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ES969_00445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES969_00450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ES969_00455	COG0512	Glutamine amidotransferase of anthranilate synthase
ES969_00460	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES969_00465	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ES969_00470	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ES969_00475	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ES969_00480	COG1396	sequence-specific DNA binding
ES969_00485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ES969_00490	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ES969_00570	COG4463	regulation of RNA biosynthetic process
ES969_00575	COG3880	PFAM UvrB UvrC protein
ES969_00580	COG3869	Catalyzes the specific phosphorylation of arginine residues in
ES969_00585	COG0542	response to heat
ES969_00590	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ES969_00595	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ES969_00600	COG4956	integral membrane protein (PIN domain superfamily)
ES969_00605	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ES969_00610	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ES969_00615	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ES969_00625	COG1045	serine acetyltransferase
ES969_00630	COG0215	cysteine-tRNA ligase activity
ES969_00635	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ES969_00640	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ES969_00645	COG3688	RNA-binding protein containing a PIN domain
ES969_00650	COG1595	DNA-templated transcription, initiation
ES969_00655	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ES969_00660	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ES969_00665	COG0250	Participates in transcription elongation, termination and antitermination
ES969_00670	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ES969_00675	COG0081	regulation of translation
ES969_00680	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ES969_00685	COG0222	ribosome binding
ES969_00690	COG2813	Specifically methylates the guanine in position
ES969_00695	COG0085	RNA polymerase activity
ES969_00700	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ES969_00705	COG1358	cellular component organization or biogenesis
ES969_00710	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ES969_00715	COG0049	tRNA binding
ES969_00720	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ES969_00725	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ES969_00730	COG0596	Alpha beta hydrolase
ES969_00735	COG0051	transcription antitermination factor activity, RNA binding
ES969_00740	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ES969_00745	COG0088	Forms part of the polypeptide exit tunnel
ES969_00750	COG0089	rRNA binding
ES969_00755	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ES969_00760	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ES969_00765	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ES969_00770	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ES969_00775	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ES969_00780	COG0255	Belongs to the universal ribosomal protein uL29 family
ES969_00785	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ES969_00790	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ES969_00800	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ES969_00810	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ES969_00815	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ES969_00820	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ES969_00825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ES969_00830	COG1841	ribosomal large subunit assembly
ES969_00835	COG0200	Binds to the 23S rRNA
ES969_00840	COG0201	protein transport
ES969_00845	COG0563	adenylate kinase activity
ES969_00850	COG0024	Methionine aminopeptidase
ES969_00855	COG2163	COG2163 Ribosomal protein L14E L6E L27E
ES969_00860	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ES969_00865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ES969_00870	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ES969_00875	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ES969_00880	COG0202	RNA polymerase activity
ES969_00885	COG0203	ribosomal protein L17
ES969_00890	COG1122	ATPase activity
ES969_00895	COG1122	ATPase activity
ES969_00900	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ES969_00905	COG0101	tRNA pseudouridine synthase activity
ES969_00910	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ES969_00915	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ES969_00920	COG2226	methyltransferase
ES969_00930	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES969_00935	COG0489	protein tyrosine kinase activity
ES969_00945	COG2194	sulfuric ester hydrolase activity
ES969_00950	COG0726	polysaccharide deacetylase
ES969_01035	COG0659	secondary active sulfate transmembrane transporter activity
ES969_01040	COG0385	Bile acid
ES969_01045	COG2819	hydrolase of the alpha beta superfamily
ES969_01050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES969_01055	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES969_01060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES969_01065	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES969_01065	COG2207	Transcriptional regulator
ES969_01070	COG3876	Protein conserved in bacteria
ES969_01075	COG1472	Belongs to the glycosyl hydrolase 3 family
ES969_01080	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ES969_01085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES969_01085	COG1263	PTS System
ES969_01090	COG1737	Transcriptional regulator
ES969_01095	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ES969_01100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES969_01105	COG1683	Conserved Protein
ES969_01135	COG1595	DNA-templated transcription, initiation
ES969_01140	COG5662	AntiSigma factor
ES969_01145	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ES969_01150	COG4856	YbbR-like protein
ES969_01155	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ES969_01160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ES969_01170	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ES969_01175	COG2169	Transcriptional regulator
ES969_01180	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ES969_01185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ES969_01190	COG3002	Belongs to the UPF0753 family
ES969_01195	COG0288	reversible hydration of carbon dioxide
ES969_01205	COG5609	conserved protein (DUF2294)
ES969_01215	COG0642	Histidine kinase
ES969_01225	COG0515	serine threonine protein kinase
ES969_01240	COG1113	amino acid transport
ES969_01255	COG2602	Beta-lactamase
ES969_01260	COG2124	cytochrome p450
ES969_01270	COG0531	amino acid
ES969_01275	COG0584	glycerophosphoryl diester phosphodiesterase
ES969_01280	COG2271	Major facilitator Superfamily
ES969_01295	COG0456	acetyltransferase
ES969_01295	COG1846	Transcriptional regulator
ES969_01315	COG3409	Peptidoglycan-binding domain 1 protein
ES969_01320	COG0697	spore germination
ES969_01325	COG1917	Cupin 2, conserved barrel domain protein
ES969_01325	COG2207	Transcriptional regulator
ES969_01350	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ES969_01355	COG3591	Belongs to the peptidase S1B family
ES969_01365	COG0596	Alpha beta hydrolase
ES969_01370	COG1183	phosphatidylcholine synthase activity
ES969_01375	COG0586	Pfam SNARE associated Golgi protein
ES969_01380	COG0688	phosphatidylethanolamine metabolic process
ES969_01390	COG2312	Erythromycin esterase
ES969_01395	COG2207	Transcriptional regulator
ES969_01405	COG1301	dicarboxylic acid transport
ES969_01410	COG2190	(PTS) system
ES969_01410	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES969_01410	COG1263	PTS System
ES969_01415	COG0363	glucosamine-6-phosphate deaminase activity
ES969_01430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES969_01435	COG0833	amino acid
ES969_01440	COG2040	homocysteine
ES969_01450	COG1115	amino acid carrier protein
ES969_01455	COG2066	Belongs to the glutaminase family
ES969_01460	COG4191	Histidine kinase
ES969_01465	COG0784	Response regulator, receiver
ES969_01475	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ES969_01480	COG1012	belongs to the aldehyde dehydrogenase family
ES969_01485	COG2271	Major facilitator Superfamily
ES969_01490	COG4948	Mandelate Racemase Muconate Lactonizing
ES969_01495	COG2186	Transcriptional regulator
ES969_01500	COG2721	sulfolactate sulfo-lyase activity
ES969_01505	COG3173	Aminoglycoside phosphotransferase
ES969_01515	COG0697	spore germination
ES969_01520	COG0745	RESPONSE REGULATOR receiver
ES969_01525	COG2205	protein histidine kinase activity
ES969_01530	COG1131	(ABC) transporter
ES969_01550	COG3773	Cell wall hydrolase
ES969_01555	COG2304	oxidoreductase activity
ES969_01565	COG3540	Alkaline phosphatase
ES969_01570	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ES969_01575	COG0805	protein transport
ES969_01580	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ES969_01585	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ES969_01590	COG0477	Major facilitator Superfamily
ES969_01595	COG1309	transcriptional regulator
ES969_01600	COG0252	asparaginase activity
ES969_01605	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ES969_01610	COG1714	RDD family
ES969_01615	COG1405	negative regulation of cell septum assembly
ES969_01615	COG3012	SEC-C Motif Domain Protein
ES969_01620	COG3290	protein histidine kinase activity
ES969_01625	COG3279	Response regulator of the LytR AlgR family
ES969_01630	COG4555	ABC transporter
ES969_01635	COG1668	transmembrane transport
ES969_01640	COG0667	Aldo Keto reductase
ES969_01655	COG1595	DNA-templated transcription, initiation
ES969_01660	COG1595	DNA-templated transcription, initiation
ES969_01665	COG1876	peptidase activity
ES969_01675	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_01680	COG0366	Alpha amylase catalytic
ES969_01685	COG0803	Belongs to the bacterial solute-binding protein 9 family
ES969_01690	COG1121	(ABC) transporter
ES969_01695	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES969_01700	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES969_01705	COG2310	stress, protein
ES969_01710	COG2310	stress, protein
ES969_01715	COG2310	stress, protein
ES969_01720	COG0861	Integral membrane protein TerC family
ES969_01730	COG3853	Toxic anion resistance protein (TelA)
ES969_01740	COG0477	Major facilitator Superfamily
ES969_01745	COG2814	Major facilitator Superfamily
ES969_01750	COG0640	Transcriptional regulator
ES969_01755	COG4175	Glycine betaine
ES969_01755	COG0517	IMP dehydrogenase activity
ES969_01760	COG4176	ABC-type proline glycine betaine transport system permease component
ES969_01765	COG2113	Glycine betaine
ES969_01770	COG1473	amidohydrolase
ES969_01775	COG1288	antiporter activity
ES969_01790	COG0039	L-malate dehydrogenase activity
ES969_01795	COG1620	l-lactate permease
ES969_01805	COG3403	YqcI/YcgG family
ES969_01810	COG1113	amino acid transport
ES969_01815	COG3665	Urea carboxylase-associated protein
ES969_01820	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ES969_01825	COG1660	Displays ATPase and GTPase activities
ES969_01835	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ES969_01845	COG2226	methyltransferase
ES969_01850	COG0583	DNA-binding transcription factor activity
ES969_01855	COG3458	cephalosporin-C deacetylase activity
ES969_01860	COG3541	Predicted nucleotidyltransferase
ES969_01865	COG0506	proline dehydrogenase activity
ES969_01870	COG1012	belongs to the aldehyde dehydrogenase family
ES969_01875	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES969_01880	COG2508	Transcriptional regulator
ES969_01885	COG3689	TIGRFAM TIGR03943 family protein
ES969_01890	COG0701	Predicted permease
ES969_01895	COG2267	carboxylic ester hydrolase activity
ES969_01900	COG0492	ferredoxin-NADP+ reductase activity
ES969_01905	COG1587	Uroporphyrinogen-III synthase
ES969_01905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ES969_01910	COG2146	nitrite reductase [NAD(P)H] activity
ES969_01915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ES969_01920	COG0243	molybdopterin cofactor binding
ES969_01925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ES969_01930	COG2223	nitrite transmembrane transporter activity
ES969_01940	COG1376	ErfK ybiS ycfS ynhG family protein
ES969_01955	COG0765	amino acid transport
ES969_01960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES969_01970	COG1714	RDD family
ES969_01980	COG1846	Transcriptional regulator
ES969_01995	COG2723	6-phospho-beta-galactosidase activity
ES969_02005	COG3209	COG3209 Rhs family protein
ES969_02010	COG0840	transmembrane signaling receptor activity
ES969_02010	COG3290	protein histidine kinase activity
ES969_02015	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ES969_02020	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ES969_02025	COG1733	regulation of RNA biosynthetic process
ES969_02030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES969_02035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES969_02040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES969_02045	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
ES969_02050	COG2814	Major facilitator Superfamily
ES969_02060	COG0697	spore germination
ES969_02070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES969_02080	COG2364	Membrane
ES969_02085	COG1126	abc transporter atp-binding protein
ES969_02090	COG0765	amino acid transport
ES969_02095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES969_02100	COG0583	DNA-binding transcription factor activity
ES969_02105	COG0163	prenyltransferase activity
ES969_02110	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ES969_02125	COG0596	Alpha beta hydrolase
ES969_02130	COG3104	oligopeptide transport
ES969_02135	COG5434	Belongs to the glycosyl hydrolase 28 family
ES969_02145	COG0697	spore germination
ES969_02155	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ES969_02160	COG1136	(ABC) transporter
ES969_02165	COG0577	efflux transmembrane transporter activity
ES969_02170	COG0745	RESPONSE REGULATOR receiver
ES969_02175	COG5002	protein histidine kinase activity
ES969_02175	COG3850	Histidine kinase
ES969_02180	COG0457	Tetratricopeptide repeat
ES969_02200	COG0527	aspartate kinase activity
ES969_02205	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES969_02210	COG4605	iron ion homeostasis
ES969_02215	COG4604	ABC transporter, ATP-binding protein
ES969_02220	COG4607	ABC-type enterochelin transport system periplasmic component
ES969_02230	COG2814	Major facilitator Superfamily
ES969_02235	COG1309	transcriptional regulator
ES969_02240	COG0778	Nitroreductase
ES969_02245	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ES969_02250	COG0640	Transcriptional regulator
ES969_02255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES969_02260	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ES969_02265	COG1012	belongs to the aldehyde dehydrogenase family
ES969_02270	COG4975	Glucose uptake
ES969_02275	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_02280	COG4549	nuclear export factor GLE1
ES969_02285	COG1276	copper resistance
ES969_02285	COG2372	response to copper ion
ES969_02290	COG1349	DNA-binding transcription factor activity
ES969_02300	COG2213	PTS system mannitol-specific
ES969_02305	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES969_02310	COG0246	Mannitol dehydrogenase
ES969_02315	COG0473	3-isopropylmalate dehydrogenase activity
ES969_02320	COG0681	Belongs to the peptidase S26 family
ES969_02330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ES969_02340	COG0561	phosphatase activity
ES969_02345	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ES969_02350	COG1914	H( )-stimulated, divalent metal cation uptake system
ES969_02355	COG4336	lyase activity
ES969_02360	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ES969_02365	COG1984	allophanate hydrolase subunit 2
ES969_02370	COG1414	Transcriptional regulator
ES969_02375	COG2755	lipolytic protein G-D-S-L family
ES969_02385	COG2329	Antibiotic biosynthesis monooxygenase
ES969_02390	COG0768	penicillin binding
ES969_02395	COG4989	oxidoreductase activity
ES969_02405	COG0318	PFAM AMP-dependent synthetase and ligase
ES969_02410	COG2226	methyltransferase
ES969_02415	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_02420	COG1917	Cupin 2, conserved barrel domain protein
ES969_02425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES969_02430	COG3871	stress protein (general stress protein 26)
ES969_02440	COG2814	Major facilitator Superfamily
ES969_02445	COG1522	sequence-specific DNA binding
ES969_02450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ES969_02450	COG0551	DNA topoisomerase type I activity
ES969_02455	COG0494	nUDIX hydrolase
ES969_02460	COG0028	Belongs to the TPP enzyme family
ES969_02490	COG1914	H( )-stimulated, divalent metal cation uptake system
ES969_02495	COG2261	transglycosylase associated protein
ES969_02500	COG4876	unkown
ES969_02505	COG2217	Heavy metal translocating P-type atpase
ES969_02510	COG3729	General stress protein
ES969_02515	COG0662	Cupin 2, conserved barrel domain protein
ES969_02520	COG2329	Antibiotic biosynthesis monooxygenase
ES969_02525	COG3546	catalase activity
ES969_02530	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ES969_02535	COG3290	protein histidine kinase activity
ES969_02540	COG4565	transcriptional regulatory protein
ES969_02545	COG1301	dicarboxylic acid transport
ES969_02550	COG0628	permease
ES969_02555	COG1131	(ABC) transporter
ES969_02560	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES969_02570	COG1960	acyl-CoA dehydrogenase activity
ES969_02585	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES969_02590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES969_02595	COG1181	Belongs to the D-alanine--D-alanine ligase family
ES969_02600	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ES969_02610	COG0513	Belongs to the DEAD box helicase family
ES969_02615	COG3402	PFAM membrane-flanked domain
ES969_02620	COG3428	Bacterial PH domain
ES969_02625	COG0705	Rhomboid family
ES969_02630	COG0736	holo-[acyl-carrier-protein] synthase activity
ES969_02635	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ES969_02640	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ES969_02645	COG0864	Transcriptional regulator
ES969_02650	COG2337	Toxic component of a toxin-antitoxin (TA) module
ES969_02655	COG1366	Belongs to the anti-sigma-factor antagonist family
ES969_02660	COG1366	Belongs to the anti-sigma-factor antagonist family
ES969_02665	COG2172	sigma factor antagonist activity
ES969_02670	COG2208	phosphoserine phosphatase activity
ES969_02675	COG1366	Belongs to the anti-sigma-factor antagonist family
ES969_02680	COG2172	sigma factor antagonist activity
ES969_02685	COG1191	sigma factor activity
ES969_02690	COG2208	phosphoserine phosphatase activity
ES969_02695	COG2183	response to ionizing radiation
ES969_02705	COG3091	SprT-like family
ES969_02745	COG0582	viral genome integration into host DNA
ES969_02750	COG2856	Zn peptidase
ES969_02755	COG1396	sequence-specific DNA binding
ES969_02780	COG1674	ftsk spoiiie
ES969_02785	COG2946	Replication initiation factor
ES969_02815	COG0433	COG0433 Predicted ATPase
ES969_02825	COG5644	endopeptidase inhibitor activity
ES969_02830	COG0791	NLP P60 protein
ES969_02830	COG0741	lytic transglycosylase activity
ES969_02850	COG0457	Tetratricopeptide repeat
ES969_02870	COG0583	DNA-binding transcription factor activity
ES969_02875	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES969_02915	COG1476	TRANSCRIPTIONal
ES969_02940	COG0693	protein deglycase activity
ES969_02945	COG1278	Cold shock
ES969_02950	COG1329	Transcriptional regulator
ES969_02960	COG0697	spore germination
ES969_02965	COG2207	Transcriptional regulator
ES969_02965	COG1917	Cupin 2, conserved barrel domain protein
ES969_02970	COG0697	spore germination
ES969_02975	COG2207	Transcriptional regulator
ES969_02975	COG3708	Transcriptional regulator
ES969_02980	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES969_02995	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
ES969_03010	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES969_03015	COG1309	transcriptional regulator
ES969_03020	COG0697	spore germination
ES969_03025	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES969_03030	COG2030	dehydratase
ES969_03035	COG3545	Serine hydrolase
ES969_03045	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES969_03050	COG0640	Transcriptional regulator
ES969_03055	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ES969_03065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES969_03070	COG0697	spore germination
ES969_03075	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES969_03080	COG0076	glutamate decarboxylase activity
ES969_03085	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ES969_03090	COG0640	Transcriptional regulator
ES969_03110	COG4585	Histidine kinase
ES969_03115	COG2197	response regulator
ES969_03120	COG2409	Drug exporters of the RND superfamily
ES969_03130	COG0596	Alpha beta hydrolase
ES969_03135	COG1811	Na channel or pump
ES969_03140	COG4978	Transcriptional regulator
ES969_03140	COG0789	Transcriptional regulator
ES969_03145	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES969_03150	COG0778	Nitroreductase
ES969_03155	COG0346	lactoylglutathione lyase activity
ES969_03160	COG2259	Doxx family
ES969_03165	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES969_03185	COG2323	membrane
ES969_03190	COG0071	Belongs to the small heat shock protein (HSP20) family
ES969_03205	COG1309	transcriptional regulator
ES969_03215	COG0456	acetyltransferase
ES969_03225	COG1113	amino acid transport
ES969_03230	COG2318	DinB family
ES969_03235	COG1846	Transcriptional regulator
ES969_03240	COG1033	growth of symbiont in host cell
ES969_03240	COG2409	Drug exporters of the RND superfamily
ES969_03245	COG0778	Nitroreductase
ES969_03250	COG1846	Transcriptional regulator
ES969_03255	COG2814	Major facilitator Superfamily
ES969_03260	COG0730	response to heat
ES969_03265	COG1802	Transcriptional regulator
ES969_03270	COG3858	chitin binding
ES969_03270	COG1388	LysM domain
ES969_03275	COG1819	glycosyl
ES969_03285	COG1785	Belongs to the alkaline phosphatase family
ES969_03290	COG5646	InterPro IPR014922
ES969_03300	COG0454	-acetyltransferase
ES969_03305	COG1078	dGTPase activity
ES969_03310	COG1388	LysM domain
ES969_03315	COG2814	Major facilitator Superfamily
ES969_03320	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES969_03325	COG1447	Phosphotransferase system cellobiose-specific component IIA
ES969_03330	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES969_03335	COG2723	6-phospho-beta-galactosidase activity
ES969_03340	COG2188	Transcriptional regulator
ES969_03345	COG1940	carbohydrate kinase activity
ES969_03350	COG1482	cell wall glycoprotein biosynthetic process
ES969_03355	COG4124	Belongs to the glycosyl hydrolase 26 family
ES969_03400	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ES969_03405	COG0802	atpase or kinase
ES969_03410	COG1214	PFAM Peptidase M22, glycoprotease
ES969_03415	COG0456	acetyltransferase
ES969_03420	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ES969_03425	COG0488	(ABC) transporter
ES969_03430	COG0315	cyclic pyranopterin monophosphate synthase activity
ES969_03435	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ES969_03440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ES969_03445	COG0805	protein transport
ES969_03455	COG1266	CAAX protease self-immunity
ES969_03460	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ES969_03465	COG0459	protein refolding
ES969_03480	COG0457	Tetratricopeptide repeat
ES969_03485	COG1063	alcohol dehydrogenase
ES969_03490	COG2211	Major facilitator Superfamily
ES969_03495	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES969_03505	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ES969_03510	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ES969_03515	COG4260	virion core protein, lumpy skin disease virus
ES969_03525	COG2814	Major facilitator Superfamily
ES969_03530	COG1063	alcohol dehydrogenase
ES969_03535	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ES969_03540	COG0823	Involved in the tonB-independent uptake of proteins
ES969_03560	COG2267	carboxylic ester hydrolase activity
ES969_03570	COG2132	Multicopper oxidase
ES969_03575	COG1113	amino acid transport
ES969_03585	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES969_03590	COG0714	Associated with various cellular activities
ES969_03595	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
ES969_03600	COG1305	Transglutaminase-like
ES969_03605	COG0519	Catalyzes the synthesis of GMP from XMP
ES969_03605	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ES969_03620	COG2252	PERMEase
ES969_03625	COG3064	Membrane
ES969_03635	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
ES969_03645	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ES969_03650	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ES969_03655	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ES969_03660	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ES969_03665	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ES969_03670	COG0047	phosphoribosylformylglycinamidine synthase activity
ES969_03675	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ES969_03680	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ES969_03685	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ES969_03690	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ES969_03695	COG0138	bifunctional purine biosynthesis protein purh
ES969_03700	COG0151	Belongs to the GarS family
ES969_03705	COG1522	sequence-specific DNA binding
ES969_03710	COG0531	amino acid
ES969_03720	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ES969_03725	COG1470	cell adhesion involved in biofilm formation
ES969_03730	COG4496	protein, YerC YecD
ES969_03735	COG0069	glutamate synthase activity
ES969_03740	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ES969_03745	COG0210	DNA helicase
ES969_03750	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ES969_03760	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES969_03765	COG1285	pathogenesis
ES969_03770	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES969_03775	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ES969_03780	COG0154	amidase activity
ES969_03785	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ES969_03790	COG1309	transcriptional regulator
ES969_03795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ES969_03800	COG1597	lipid kinase activity
ES969_03805	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ES969_03825	COG5444	nuclease activity
ES969_03835	COG3586	endonuclease activity
ES969_03845	COG0457	Tetratricopeptide repeat
ES969_03855	COG0217	transcriptional regulatory protein
ES969_03865	COG1309	transcriptional regulator
ES969_03870	COG3631	Ketosteroid isomerase-related protein
ES969_03875	COG0702	epimerase
ES969_03890	COG3546	catalase activity
ES969_03895	COG0454	-acetyltransferase
ES969_03905	COG5578	integral membrane protein
ES969_03910	COG2972	Histidine kinase
ES969_03915	COG2207	Transcriptional regulator
ES969_03915	COG4753	response regulator
ES969_03920	COG1653	transport
ES969_03925	COG1175	transmembrane transport
ES969_03940	COG3401	FG-GAP repeat protein
ES969_03945	COG2755	lipolytic protein G-D-S-L family
ES969_03960	COG1653	transport
ES969_03970	COG0395	ABC-type sugar transport system, permease component
ES969_03975	COG1486	melibiose metabolic process
ES969_03980	COG2323	membrane
ES969_03985	COG2329	Antibiotic biosynthesis monooxygenase
ES969_03990	COG0346	lactoylglutathione lyase activity
ES969_04005	COG5583	Uncharacterized small protein (DUF2292)
ES969_04010	COG0670	Belongs to the BI1 family
ES969_04015	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ES969_04020	COG1715	Restriction endonuclease
ES969_04030	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ES969_04030	COG2124	cytochrome p450
ES969_04035	COG1368	sulfuric ester hydrolase activity
ES969_04040	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ES969_04045	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES969_04050	COG1442	glycosyl transferase family 8
ES969_04055	COG1216	Glycosyl transferase, family 2
ES969_04060	COG1442	glycosyl transferase family 8
ES969_04065	COG2223	nitrite transmembrane transporter activity
ES969_04070	COG1011	Hydrolase
ES969_04075	COG0531	amino acid
ES969_04080	COG1012	belongs to the aldehyde dehydrogenase family
ES969_04085	COG0840	transmembrane signaling receptor activity
ES969_04090	COG0488	(ABC) transporter
ES969_04100	COG0789	Transcriptional regulator
ES969_04105	COG2814	Major facilitator Superfamily
ES969_04125	COG0488	(ABC) transporter
ES969_04130	COG0513	Belongs to the DEAD box helicase family
ES969_04135	COG0456	acetyltransferase
ES969_04150	COG2130	NADP-dependent
ES969_04155	COG1120	ATPase activity
ES969_04160	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES969_04165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES969_04170	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ES969_04185	COG3866	Pectate lyase
ES969_04190	COG0471	metal ion transport
ES969_04195	COG3290	protein histidine kinase activity
ES969_04200	COG4565	transcriptional regulatory protein
ES969_04205	COG3181	Tripartite tricarboxylate transporter family receptor
ES969_04210	COG2851	Citrate transporter
ES969_04215	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES969_04220	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
ES969_04225	COG1254	Belongs to the acylphosphatase family
ES969_04230	COG2258	MOSC domain
ES969_04250	COG0024	Methionine aminopeptidase
ES969_04255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES969_04255	COG1263	PTS System
ES969_04260	COG1368	sulfuric ester hydrolase activity
ES969_04275	COG1115	amino acid carrier protein
ES969_04290	COG0697	spore germination
ES969_04295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES969_04295	COG1263	PTS System
ES969_04300	COG0366	Alpha amylase catalytic
ES969_04305	COG2188	Transcriptional regulator
ES969_04310	COG0778	Nitroreductase
ES969_04315	COG0737	Belongs to the 5'-nucleotidase family
ES969_04320	COG0693	protein deglycase activity
ES969_04325	COG2814	Major facilitator Superfamily
ES969_04330	COG4840	Belongs to the UPF0435 family
ES969_04335	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ES969_04340	COG4980	gas vesicle protein
ES969_04345	COG1295	ribonuclease BN
ES969_04350	COG0477	Major facilitator Superfamily
ES969_04355	COG0387	Pfam Sodium calcium exchanger
ES969_04365	COG0668	transmembrane transport
ES969_04370	COG0535	radical SAM domain protein
ES969_04380	COG0726	polysaccharide deacetylase
ES969_04385	COG2084	Dehydrogenase
ES969_04390	COG0598	Magnesium transport protein CorA
ES969_04395	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ES969_04400	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ES969_04410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ES969_04415	COG4637	Psort location Cytoplasmic, score
ES969_04425	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES969_04430	COG0022	dehydrogenase e1 component
ES969_04435	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES969_04440	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES969_04445	COG3284	Transcriptional regulator
ES969_04455	COG1742	UPF0060 membrane protein
ES969_04480	COG4842	Belongs to the WXG100 family
ES969_04485	COG1486	melibiose metabolic process
ES969_04490	COG1737	Transcriptional regulator
ES969_04495	COG1263	PTS System
ES969_04495	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES969_04500	COG1132	(ABC) transporter
ES969_04505	COG1132	(ABC) transporter
ES969_04510	COG2259	Doxx family
ES969_04515	COG2514	catechol 2,3-dioxygenase activity
ES969_04520	COG1917	Cupin 2, conserved barrel domain protein
ES969_04520	COG4977	sequence-specific DNA binding
ES969_04525	COG2814	Major facilitator Superfamily
ES969_04530	COG1082	Xylose isomerase domain protein TIM barrel
ES969_04540	COG4585	Histidine kinase
ES969_04545	COG2197	response regulator
ES969_04550	COG1131	(ABC) transporter
ES969_04555	COG1511	domain protein
ES969_04555	COG0842	Transport permease protein
ES969_04560	COG0842	Transport permease protein
ES969_04565	COG1695	Transcriptional regulator
ES969_04570	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ES969_04575	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
ES969_04580	COG1309	transcriptional regulator
ES969_04585	COG2814	Major facilitator Superfamily
ES969_04590	COG2318	DinB family
ES969_04595	COG2814	Major facilitator Superfamily
ES969_04600	COG1846	Transcriptional regulator
ES969_04605	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ES969_04605	COG0392	lysyltransferase activity
ES969_04610	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES969_04615	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES969_04620	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES969_04630	COG0778	Nitroreductase
ES969_04645	COG1090	epimerase
ES969_04650	COG2137	regulation of response to DNA damage stimulus
ES969_04660	COG2814	Major facilitator Superfamily
ES969_04675	COG3103	Sh3 type 3 domain protein
ES969_04680	COG5658	integral membrane protein
ES969_04685	COG0596	Alpha beta hydrolase
ES969_04690	COG0463	Glycosyl transferase, family 2
ES969_04695	COG4485	Bacterial membrane protein, YfhO
ES969_04700	COG1988	membrane-bound metal-dependent
ES969_04705	COG1194	a g-specific adenine glycosylase
ES969_04715	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_04730	COG3557	Belongs to the UPF0374 family
ES969_04735	COG1132	(ABC) transporter
ES969_04740	COG4129	membrane
ES969_04745	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ES969_04750	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ES969_04755	COG0735	belongs to the Fur family
ES969_04865	COG4326	sporulation control protein
ES969_04875	COG5577	PFAM Coat F domain
ES969_04880	COG3340	Belongs to the peptidase S51 family
ES969_04885	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ES969_04900	COG0753	catalase activity
ES969_04905	COG1116	anion transmembrane transporter activity
ES969_04915	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ES969_04920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES969_04930	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ES969_04940	COG1476	TRANSCRIPTIONal
ES969_04950	COG3382	B3 4 domain protein
ES969_04955	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ES969_04965	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ES969_04970	COG0789	Transcriptional regulator
ES969_04975	COG1664	Polymer-forming cytoskeletal
ES969_04980	COG1664	Polymer-forming cytoskeletal
ES969_04985	COG2766	serine protein kinase
ES969_04990	COG2718	Belongs to the UPF0229 family
ES969_04995	COG1846	Transcriptional regulator
ES969_05000	COG1566	PFAM secretion protein HlyD family protein
ES969_05005	COG2814	Major facilitator Superfamily
ES969_05010	COG0655	NAD(P)H dehydrogenase (quinone) activity
ES969_05030	COG1725	Transcriptional regulator
ES969_05035	COG1131	(ABC) transporter
ES969_05040	COG1131	(ABC) transporter
ES969_05045	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES969_05050	COG1278	Cold shock
ES969_05060	COG1464	Belongs to the NlpA lipoprotein family
ES969_05070	COG1823	symporter activity
ES969_05075	COG5444	nuclease activity
ES969_05100	COG0582	viral genome integration into host DNA
ES969_05105	COG2946	Replication initiation factor
ES969_05155	COG5644	endopeptidase inhibitor activity
ES969_05160	COG0741	lytic transglycosylase activity
ES969_05160	COG0791	NLP P60 protein
ES969_05180	COG0457	Tetratricopeptide repeat
ES969_05205	COG4085	toxin activity
ES969_05205	COG0737	Belongs to the 5'-nucleotidase family
ES969_05205	COG1525	nuclease
ES969_05210	COG3764	Sortase (surface protein transpeptidase)
ES969_05215	COG0564	pseudouridine synthase activity
ES969_05225	COG0517	IMP dehydrogenase activity
ES969_05230	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ES969_05235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ES969_05235	COG3153	acetyltransferase
ES969_05245	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES969_05250	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ES969_05255	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ES969_05260	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ES969_05265	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ES969_05270	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ES969_05275	COG4585	Histidine kinase
ES969_05275	COG2203	Gaf domain
ES969_05280	COG2197	response regulator
ES969_05285	COG0431	NADPH-dependent FMN reductase
ES969_05300	COG0791	NLP P60 protein
ES969_05300	COG1388	LysM domain
ES969_05305	COG1959	2 iron, 2 sulfur cluster binding
ES969_05310	COG0668	transmembrane transport
ES969_05315	COG2719	SpoVR family
ES969_05320	COG1785	Belongs to the alkaline phosphatase family
ES969_05325	COG1388	LysM domain
ES969_05325	COG0791	NLP P60 protein
ES969_05330	COG0583	DNA-binding transcription factor activity
ES969_05335	COG0372	Belongs to the citrate synthase family
ES969_05340	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_05350	COG0733	neurotransmitter:sodium symporter activity
ES969_05355	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES969_05360	COG0456	acetyltransferase
ES969_05375	COG1595	DNA-templated transcription, initiation
ES969_05380	COG0667	Aldo Keto reductase
ES969_05385	COG0204	Acyl-transferase
ES969_05390	COG1253	flavin adenine dinucleotide binding
ES969_05395	COG0789	Transcriptional regulator
ES969_05400	COG0436	Aminotransferase
ES969_05405	COG1253	flavin adenine dinucleotide binding
ES969_05410	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ES969_05415	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ES969_05420	COG0584	glycerophosphoryl diester phosphodiesterase
ES969_05430	COG0668	transmembrane transport
ES969_05435	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ES969_05440	COG0726	polysaccharide deacetylase
ES969_05445	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES969_05450	COG1757	Na H antiporter
ES969_05455	COG0589	response to stress
ES969_05465	COG1132	(ABC) transporter
ES969_05470	COG1132	(ABC) transporter
ES969_05475	COG0702	epimerase
ES969_05495	COG0189	ligase activity
ES969_05500	COG0189	ligase activity
ES969_05505	COG4399	Belongs to the UPF0754 family
ES969_05510	COG3679	Belongs to the UPF0342 family
ES969_05515	COG4335	DNA alkylation repair
ES969_05520	COG0561	phosphatase activity
ES969_05525	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ES969_05530	COG0475	glutathione-regulated potassium exporter activity
ES969_05535	COG0490	domain, Protein
ES969_05545	COG1024	Enoyl-CoA hydratase
ES969_05555	COG4152	abc transporter atp-binding protein
ES969_05560	COG1668	transmembrane transport
ES969_05565	COG0420	3'-5' exonuclease activity
ES969_05570	COG4717	serine-type aminopeptidase activity
ES969_05575	COG3481	metal-dependent phosphohydrolase, HD sub domain
ES969_05585	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ES969_05615	COG1846	Transcriptional regulator
ES969_05620	COG4980	gas vesicle protein
ES969_05635	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ES969_05640	COG0537	adenosine 5'-monophosphoramidase activity
ES969_05645	COG1131	(ABC) transporter
ES969_05650	COG4473	ABC transporter
ES969_05660	COG1473	amidohydrolase
ES969_05665	COG3069	C4-dicarboxylate transmembrane transporter activity
ES969_05675	COG2329	Antibiotic biosynthesis monooxygenase
ES969_05680	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES969_05685	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ES969_05700	COG1309	transcriptional regulator
ES969_05705	COG1511	domain protein
ES969_05710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES969_05715	COG4377	Putative membrane peptidase family (DUF2324)
ES969_05725	COG1363	Peptidase, m42
ES969_05730	COG4405	Protein conserved in bacteria
ES969_05735	COG1301	dicarboxylic acid transport
ES969_05745	COG1234	tRNA 3'-trailer cleavage
ES969_05750	COG0095	Lipoate-protein ligase
ES969_05755	COG0702	epimerase
ES969_05760	COG0318	PFAM AMP-dependent synthetase and ligase
ES969_05770	COG0501	Belongs to the peptidase M48B family
ES969_05775	COG1404	Belongs to the peptidase S8 family
ES969_05780	COG0456	acetyltransferase
ES969_05785	COG0604	alcohol dehydrogenase
ES969_05790	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ES969_05795	COG0406	alpha-ribazole phosphatase activity
ES969_05800	COG0183	Belongs to the thiolase family
ES969_05805	COG0318	PFAM AMP-dependent synthetase and ligase
ES969_05810	COG1268	BioY protein
ES969_05815	COG0840	transmembrane signaling receptor activity
ES969_05825	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_05835	COG4903	ComK protein
ES969_05840	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_05850	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES969_05865	COG0398	Pfam SNARE associated Golgi protein
ES969_05870	COG0681	Belongs to the peptidase S26 family
ES969_05875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ES969_05880	COG1846	Transcriptional regulator
ES969_05890	COG0738	Major facilitator superfamily
ES969_05895	COG0673	inositol 2-dehydrogenase activity
ES969_05900	COG0561	phosphatase activity
ES969_05905	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES969_05910	COG1609	Transcriptional regulator
ES969_05915	COG3180	Ammonia monooxygenase
ES969_05920	COG0477	Major facilitator Superfamily
ES969_05920	COG2814	Major facilitator Superfamily
ES969_05925	COG4533	DNA binding
ES969_05935	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ES969_05940	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ES969_05945	COG1074	ATP-dependent DNA helicase activity
ES969_05950	COG0420	3'-5' exonuclease activity
ES969_05955	COG0419	ATPase involved in DNA repair
ES969_05960	COG1403	HNH endonuclease
ES969_06000	COG5337	Spore coat protein CotH
ES969_06005	COG0179	Fumarylacetoacetate (FAA) hydrolase
ES969_06015	COG1404	Belongs to the peptidase S8 family
ES969_06025	COG0367	asparagine synthase
ES969_06030	COG1562	ergosterol biosynthetic process
ES969_06035	COG0534	Mate efflux family protein
ES969_06040	COG2207	Transcriptional regulator
ES969_06040	COG1917	Cupin 2, conserved barrel domain protein
ES969_06045	COG1609	Transcriptional regulator
ES969_06050	COG0673	inositol 2-dehydrogenase activity
ES969_06055	COG2318	DinB family
ES969_06060	COG1279	arginine transmembrane transporter activity
ES969_06065	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES969_06070	COG1357	PFAM Pentapeptide repeats (8 copies)
ES969_06075	COG2267	carboxylic ester hydrolase activity
ES969_06085	COG2153	protein acetylation
ES969_06090	COG0646	methionine synthase
ES969_06090	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ES969_06095	COG1666	GTP binding
ES969_06100	COG2996	Protein conserved in bacteria
ES969_06110	COG1307	EDD domain protein, DegV family
ES969_06115	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES969_06130	COG0561	phosphatase activity
ES969_06135	COG1073	alpha beta
ES969_06140	COG2151	metal-sulfur cluster biosynthetic enzyme
ES969_06150	COG0277	FAD linked oxidase domain protein
ES969_06155	COG2271	Major facilitator Superfamily
ES969_06160	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ES969_06175	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ES969_06180	COG0505	Belongs to the CarA family
ES969_06185	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ES969_06190	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ES969_06210	COG2267	carboxylic ester hydrolase activity
ES969_06220	COG1744	ABC transporter substrate-binding protein PnrA-like
ES969_06235	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES969_06240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ES969_06245	COG5504	Zn-dependent protease
ES969_06250	COG0444	Belongs to the ABC transporter superfamily
ES969_06255	COG4608	Belongs to the ABC transporter superfamily
ES969_06265	COG0601	transmembrane transport
ES969_06270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES969_06280	COG0180	Tryptophanyl-tRNA synthetase
ES969_06285	COG4166	transmembrane transport
ES969_06290	COG0601	transmembrane transport
ES969_06295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES969_06300	COG0444	Belongs to the ABC transporter superfamily
ES969_06305	COG4608	Belongs to the ABC transporter superfamily
ES969_06310	COG2814	Major facilitator Superfamily
ES969_06315	COG0456	acetyltransferase
ES969_06320	COG1393	Belongs to the ArsC family
ES969_06325	COG0861	Integral membrane protein TerC family
ES969_06335	COG4862	establishment of competence for transformation
ES969_06345	COG4469	Competence protein
ES969_06350	COG1164	Oligoendopeptidase f
ES969_06370	COG2346	COG2346, Truncated hemoglobins
ES969_06375	COG0741	lytic transglycosylase activity
ES969_06380	COG4116	CYTH
ES969_06390	COG2357	RelA SpoT domain protein
ES969_06395	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ES969_06400	COG0564	pseudouridine synthase activity
ES969_06405	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ES969_06410	COG0475	glutathione-regulated potassium exporter activity
ES969_06410	COG0569	domain protein
ES969_06415	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ES969_06420	COG0352	thiamine-phosphate diphosphorylase activity
ES969_06425	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ES969_06430	COG2104	thiamine diphosphate biosynthetic process
ES969_06435	COG2022	thiamine diphosphate biosynthetic process
ES969_06440	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ES969_06445	COG0351	phosphomethylpyrimidine kinase
ES969_06450	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ES969_06505	COG0210	DNA helicase
ES969_06515	COG2153	protein acetylation
ES969_06520	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ES969_06525	COG2382	esterase
ES969_06530	COG0626	cystathionine gamma-synthase activity
ES969_06535	COG0626	cystathionine gamma-synthase activity
ES969_06540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES969_06545	COG5505	Protein of unknown function (DUF819)
ES969_06580	COG1396	sequence-specific DNA binding
ES969_06640	COG0457	Tetratricopeptide repeat
ES969_06645	COG5444	nuclease activity
ES969_06660	COG3328	transposase activity
ES969_06665	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES969_06675	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ES969_06695	COG0109	protoheme IX farnesyltransferase activity
ES969_06705	COG0726	polysaccharide deacetylase
ES969_06720	COG5504	Zn-dependent protease
ES969_06725	COG2205	protein histidine kinase activity
ES969_06740	COG2427	Protein of unknown function (DUF1641)
ES969_06750	COG1051	belongs to the nudix hydrolase family
ES969_06760	COG2124	cytochrome p450
ES969_06765	COG1819	glycosyl
ES969_06775	COG1587	Uroporphyrinogen-III synthase
ES969_06780	COG0390	transport system, permease component
ES969_06785	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES969_06790	COG0697	spore germination
ES969_06805	COG1252	NADH dehydrogenase
ES969_06810	COG1904	glucuronate isomerase
ES969_06820	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
ES969_06825	COG1063	alcohol dehydrogenase
ES969_06830	COG1312	Catalyzes the dehydration of D-mannonate
ES969_06835	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_06840	COG2271	Major facilitator Superfamily
ES969_06845	COG1609	Transcriptional regulator
ES969_06850	COG0246	Mannitol dehydrogenase
ES969_06855	COG2721	sulfolactate sulfo-lyase activity
ES969_06860	COG0730	response to heat
ES969_06865	COG2318	DinB family
ES969_06885	COG0457	Tetratricopeptide repeat
ES969_06900	COG1388	LysM domain
ES969_06900	COG3409	Peptidoglycan-binding domain 1 protein
ES969_06900	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES969_06910	COG4195	phage-related replication protein
ES969_06915	COG3546	catalase activity
ES969_06920	COG2856	Zn peptidase
ES969_06925	COG1396	sequence-specific DNA binding
ES969_06935	COG1522	sequence-specific DNA binding
ES969_06940	COG1484	DNA-dependent DNA replication
ES969_06960	COG1595	DNA-templated transcription, initiation
ES969_06965	COG5484	DNA packaging
ES969_06965	COG3728	DNA packaging
ES969_06970	COG1783	phage Terminase large subunit
ES969_06975	COG5518	Phage portal protein
ES969_06980	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ES969_06985	COG4653	Phage capsid family
ES969_07035	COG5412	phage tail tape measure protein
ES969_07035	COG3953	SLT domain
ES969_07035	COG5412	phage tail tape measure protein
ES969_07035	COG3953	SLT domain
ES969_07035	COG5412	phage tail tape measure protein
ES969_07035	COG3953	SLT domain
ES969_07040	COG1652	LysM domain
ES969_07045	COG4193	domain, Protein
ES969_07055	COG3628	GPW Gp25 family protein
ES969_07060	COG3299	homolog of phage Mu protein gp47
ES969_07065	COG3778	Protein conserved in bacteria
ES969_07105	COG3409	Peptidoglycan-binding domain 1 protein
ES969_07105	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES969_07125	COG0306	phosphate transporter
ES969_07130	COG1392	Phosphate transport regulator
ES969_07135	COG0531	amino acid
ES969_07140	COG0346	lactoylglutathione lyase activity
ES969_07145	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ES969_07150	COG0463	Glycosyl transferase, family 2
ES969_07155	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES969_07160	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES969_07165	COG2362	D-Aminopeptidase
ES969_07170	COG0601	transmembrane transport
ES969_07175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES969_07180	COG0444	Belongs to the ABC transporter superfamily
ES969_07185	COG4166	transmembrane transport
ES969_07190	COG1619	proteins homologs of microcin C7 resistance protein MccF
ES969_07195	COG4948	Mandelate Racemase Muconate Lactonizing
ES969_07200	COG0791	NLP P60 protein
ES969_07205	COG4608	Belongs to the ABC transporter superfamily
ES969_07210	COG2706	6-phosphogluconolactonase activity
ES969_07220	COG1607	acyl-coa hydrolase
ES969_07225	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ES969_07225	COG1017	nitric oxide dioxygenase activity
ES969_07235	COG2323	membrane
ES969_07240	COG2318	DinB family
ES969_07250	COG2076	Multidrug Resistance protein
ES969_07255	COG2076	Multidrug Resistance protein
ES969_07260	COG0788	formyltetrahydrofolate deformylase activity
ES969_07265	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ES969_07270	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ES969_07275	COG1764	response to oxidative stress
ES969_07280	COG1846	Transcriptional regulator
ES969_07285	COG1764	response to oxidative stress
ES969_07295	COG0590	tRNA wobble adenosine to inosine editing
ES969_07300	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ES969_07305	COG1404	Belongs to the peptidase S8 family
ES969_07310	COG1366	Belongs to the anti-sigma-factor antagonist family
ES969_07315	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ES969_07320	COG1122	ATPase activity
ES969_07325	COG4721	ABC-type cobalt transport system, permease component
ES969_07335	COG0745	RESPONSE REGULATOR receiver
ES969_07340	COG5002	protein histidine kinase activity
ES969_07340	COG3850	Histidine kinase
ES969_07350	COG3212	peptidase
ES969_07365	COG2239	Acts as a magnesium transporter
ES969_07370	COG0789	Transcriptional regulator
ES969_07385	COG1846	Transcriptional regulator
ES969_07395	COG0726	polysaccharide deacetylase
ES969_07400	COG1408	metallophosphoesterase
ES969_07410	COG0463	Glycosyl transferase, family 2
ES969_07415	COG1793	dna ligase
ES969_07415	COG3285	dna ligase
ES969_07420	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ES969_07425	COG5001	Diguanylate cyclase
ES969_07425	COG3300	MHYT domain
ES969_07430	COG0586	Pfam SNARE associated Golgi protein
ES969_07435	COG0861	Integral membrane protein TerC family
ES969_07440	COG1191	sigma factor activity
ES969_07460	COG0501	Belongs to the peptidase M48B family
ES969_07465	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ES969_07480	COG3594	Acyltransferase
ES969_07485	COG5002	protein histidine kinase activity
ES969_07490	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ES969_07500	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ES969_07505	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
ES969_07510	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ES969_07515	COG0436	Aminotransferase
ES969_07520	COG1850	ribulose-bisphosphate carboxylase activity
ES969_07525	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ES969_07530	COG0235	Class ii aldolase
ES969_07535	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ES969_07540	COG3339	Conserved Protein
ES969_07555	COG3852	Histidine kinase
ES969_07565	COG1846	Transcriptional regulator
ES969_07570	COG1360	Flagellar Motor Protein
ES969_07575	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ES969_07585	COG0542	response to heat
ES969_07590	COG3949	Membrane
ES969_07595	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ES969_07600	COG0720	synthase
ES969_07605	COG0602	queuosine metabolic process
ES969_07610	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ES969_07620	COG4873	Protein conserved in bacteria
ES969_07630	COG3773	Cell wall hydrolase
ES969_07635	COG2244	polysaccharide biosynthetic process
ES969_07640	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES969_07645	COG2217	Heavy metal translocating P-type atpase
ES969_07655	COG0006	proline dipeptidase activity
ES969_07660	COG1609	Transcriptional regulator
ES969_07665	COG3711	transcriptional antiterminator
ES969_07670	COG2190	(PTS) system
ES969_07670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES969_07670	COG1263	PTS System
ES969_07675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES969_07680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ES969_07690	COG1533	DNA photolyase activity
ES969_07695	COG0456	acetyltransferase
ES969_07700	COG0840	transmembrane signaling receptor activity
ES969_07705	COG2084	Dehydrogenase
ES969_07710	COG3328	transposase activity
ES969_07720	COG2340	Cysteine-rich secretory protein family
ES969_07725	COG0768	penicillin binding
ES969_07730	COG4191	Histidine kinase
ES969_07735	COG0436	Aminotransferase
ES969_07745	COG0784	Response regulator, receiver
ES969_07745	COG0835	chemotaxis
ES969_07755	COG2814	Major facilitator Superfamily
ES969_07760	COG1376	ErfK ybiS ycfS ynhG family protein
ES969_07765	COG1408	metallophosphoesterase
ES969_07770	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_07775	COG2200	EAL domain
ES969_07780	COG4703	Protein of unknown function (DUF1797)
ES969_07785	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
ES969_07795	COG0517	IMP dehydrogenase activity
ES969_07800	COG0583	DNA-binding transcription factor activity
ES969_07805	COG0716	FMN binding
ES969_07815	COG0716	FMN binding
ES969_07820	COG2171	N-acyltransferase activity
ES969_07825	COG1473	amidohydrolase
ES969_07835	COG0668	transmembrane transport
ES969_07840	COG0450	alkyl hydroperoxide reductase
ES969_07845	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES969_07865	COG0746	molybdenum cofactor guanylyltransferase activity
ES969_07870	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ES969_07875	COG0303	'Molybdopterin
ES969_07880	COG1763	Mo-molybdopterin cofactor biosynthetic process
ES969_07885	COG0314	molybdopterin synthase activity
ES969_07890	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ES969_07895	COG1132	(ABC) transporter
ES969_07900	COG1132	(ABC) transporter
ES969_07910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ES969_07915	COG1136	(ABC) transporter
ES969_07920	COG0577	efflux transmembrane transporter activity
ES969_07925	COG1349	DNA-binding transcription factor activity
ES969_07930	COG1105	Belongs to the carbohydrate kinase PfkB family
ES969_07935	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES969_07935	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES969_07935	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES969_07940	COG0681	Belongs to the peptidase S26 family
ES969_07950	COG0488	(ABC) transporter
ES969_07955	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ES969_07960	COG2309	aminopeptidase activity
ES969_07970	COG1077	Cell shape determining protein MreB Mrl
ES969_07975	COG2002	toxin-antitoxin pair type II binding
ES969_07980	COG3852	Histidine kinase
ES969_07985	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
ES969_07985	COG2105	PFAM AIG2 family protein
ES969_07990	COG0569	domain protein
ES969_07995	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ES969_08000	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ES969_08010	COG0561	phosphatase activity
ES969_08015	COG0242	peptide deformylase activity
ES969_08025	COG0497	DNA recombination
ES969_08030	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES969_08035	COG0022	dehydrogenase e1 component
ES969_08040	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES969_08045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES969_08050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES969_08060	COG1982	Orn Lys Arg decarboxylase major
ES969_08065	COG4476	Belongs to the UPF0223 family
ES969_08070	COG4493	Belongs to the UPF0637 family
ES969_08080	COG0483	inositol monophosphate 1-phosphatase activity
ES969_08090	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ES969_08140	COG4896	Protein conserved in bacteria
ES969_08150	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ES969_08155	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ES969_08160	COG2066	Belongs to the glutaminase family
ES969_08165	COG4838	Belongs to the UPF0358 family
ES969_08170	COG0772	Belongs to the SEDS family
ES969_08175	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ES969_08185	COG1612	heme a metabolic process
ES969_08190	COG0109	protoheme IX farnesyltransferase activity
ES969_08195	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ES969_08195	COG2010	Cytochrome c
ES969_08200	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ES969_08205	COG1845	cytochrome c oxidase, subunit III
ES969_08210	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ES969_08215	COG3336	cytochrome c oxidase
ES969_08225	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ES969_08230	COG2340	Cysteine-rich secretory protein family
ES969_08245	COG3679	Belongs to the UPF0342 family
ES969_08250	COG4471	UPF0298 protein
ES969_08255	COG0742	ribosomal rna small subunit methyltransferase
ES969_08260	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ES969_08265	COG3314	Sporulation integral membrane protein YlbJ
ES969_08270	COG1752	Esterase of the alpha-beta hydrolase superfamily
ES969_08275	COG3480	Lon protease (S16) C-terminal proteolytic domain
ES969_08280	COG1323	Belongs to the UPF0348 family
ES969_08290	COG1399	metal-binding, possibly nucleic acid-binding protein
ES969_08295	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ES969_08305	COG0454	-acetyltransferase
ES969_08310	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ES969_08315	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ES969_08320	COG2001	Belongs to the MraZ family
ES969_08325	COG0275	rRNA processing
ES969_08330	COG4839	cell division protein FtsL
ES969_08340	COG0768	penicillin binding
ES969_08345	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ES969_08350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ES969_08355	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ES969_08360	COG0772	Belongs to the SEDS family
ES969_08365	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ES969_08370	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ES969_08375	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ES969_08380	COG3879	Bacterial protein of unknown function (DUF881)
ES969_08385	COG3879	Bacterial protein of unknown function (DUF881)
ES969_08390	COG3856	small basic protein
ES969_08395	COG0849	cell division
ES969_08400	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ES969_08405	COG4412	M6 family metalloprotease domain protein
ES969_08405	COG1404	Belongs to the peptidase S8 family
ES969_08415	COG1191	sigma factor activity
ES969_08420	COG1191	sigma factor activity
ES969_08425	COG1119	ATPase activity
ES969_08430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES969_08435	COG1873	PFAM PRC-barrel domain
ES969_08445	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ES969_08450	COG1799	cell septum assembly
ES969_08455	COG0762	integral membrane protein
ES969_08460	COG2302	S4 RNA-binding domain
ES969_08465	COG3599	regulation of cell shape
ES969_08470	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ES969_08475	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES969_08480	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ES969_08485	COG0564	pseudouridine synthase activity
ES969_08490	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ES969_08495	COG2233	PERMEase
ES969_08500	COG0540	Belongs to the ATCase OTCase family
ES969_08505	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ES969_08510	COG0505	Belongs to the CarA family
ES969_08515	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ES969_08520	COG0543	2 iron, 2 sulfur cluster binding
ES969_08525	COG0167	dihydroorotate dehydrogenase activity
ES969_08530	COG0284	orotidine-5'-phosphate decarboxylase activity
ES969_08535	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ES969_08540	COG0175	sulfate reduction
ES969_08545	COG0306	phosphate transporter
ES969_08550	COG2046	Belongs to the sulfate adenylyltransferase family
ES969_08555	COG0529	Catalyzes the synthesis of activated sulfate
ES969_08560	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ES969_08565	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
ES969_08570	COG1648	precorrin-2 dehydrogenase activity
ES969_08580	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ES969_08585	COG1561	YicC-like family, N-terminal region
ES969_08590	COG2052	Domain of unknown function (DUF370)
ES969_08595	COG0194	GDP metabolic process
ES969_08600	COG1758	RNA polymerase activity
ES969_08605	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ES969_08610	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ES969_08615	COG0242	peptide deformylase activity
ES969_08620	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ES969_08625	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ES969_08625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ES969_08630	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ES969_08635	COG0631	protein serine/threonine phosphatase activity
ES969_08640	COG0515	serine threonine protein kinase
ES969_08640	COG2815	serine threonine protein kinase
ES969_08645	COG1162	GTPase activity
ES969_08650	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ES969_08655	COG1564	THIamine pyrophosphokinase
ES969_08665	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ES969_08670	COG1302	Protein conserved in bacteria
ES969_08675	COG1461	Dihydroxyacetone kinase
ES969_08680	COG1760	l-serine dehydratase
ES969_08685	COG1760	l-serine dehydratase
ES969_08690	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ES969_08695	COG2050	protein possibly involved in aromatic compounds catabolism
ES969_08695	COG1349	DNA-binding transcription factor activity
ES969_08700	COG0416	fatty acid biosynthetic process
ES969_08705	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ES969_08710	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_08715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES969_08720	COG0571	ribonuclease III activity
ES969_08725	COG1196	nuclear chromosome segregation
ES969_08730	COG0552	protein localization to endoplasmic reticulum
ES969_08740	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ES969_08745	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ES969_08750	COG0228	four-way junction DNA binding
ES969_08755	COG1837	Belongs to the UPF0109 family
ES969_08765	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ES969_08770	COG0336	Belongs to the RNA methyltransferase TrmD family
ES969_08775	COG0335	large ribosomal subunit rRNA binding
ES969_08780	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ES969_08785	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ES969_08795	COG2257	FlhB HrpN YscU SpaS Family
ES969_08800	COG0045	succinate-CoA ligase (ADP-forming) activity
ES969_08805	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ES969_08810	COG0758	DNA mediated transformation
ES969_08815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ES969_08820	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ES969_08825	COG4974	Belongs to the 'phage' integrase family
ES969_08830	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ES969_08835	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ES969_08840	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ES969_08845	COG1815	bacterial-type flagellum-dependent cell motility
ES969_08850	COG1558	bacterial-type flagellum-dependent cell motility
ES969_08855	COG1677	Flagellar hook-basal body complex protein FliE
ES969_08860	COG1766	The M ring may be actively involved in energy transduction
ES969_08865	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES969_08870	COG1317	bacterial-type flagellum organization
ES969_08875	COG1157	protein secretion by the type III secretion system
ES969_08880	COG2882	bacterial-type flagellum organization
ES969_08885	COG3334	PFAM MgtE intracellular
ES969_08890	COG3144	bacterial-type flagellum assembly
ES969_08895	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ES969_08900	COG4786	Flagellar basal body rod
ES969_08905	COG1582	Flagellar protein (FlbD)
ES969_08910	COG1580	Controls the rotational direction of flagella during chemotaxis
ES969_08915	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES969_08920	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES969_08920	COG1776	CheC inhibitor of MCP methylation
ES969_08925	COG2201	protein-glutamate methylesterase activity
ES969_08930	COG3190	flagellar
ES969_08935	COG1338	Plays a role in the flagellum-specific transport system
ES969_08940	COG1987	bacterial-type flagellum assembly
ES969_08945	COG1684	flagellar biosynthetic protein fliR
ES969_08950	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ES969_08955	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ES969_08960	COG1419	protein localization to endoplasmic reticulum
ES969_08965	COG0455	bacterial-type flagellum organization
ES969_08970	COG2201	protein-glutamate methylesterase activity
ES969_08975	COG2198	Histidine kinase
ES969_08975	COG0643	Histidine kinase
ES969_08980	COG0835	chemotaxis
ES969_08985	COG1776	CheC inhibitor of MCP methylation
ES969_08990	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ES969_08995	COG1191	sigma factor activity
ES969_09005	COG0052	Belongs to the universal ribosomal protein uS2 family
ES969_09010	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ES969_09015	COG0528	UMP kinase activity
ES969_09020	COG0233	cytoplasmic translational termination
ES969_09025	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ES969_09030	COG4589	Belongs to the CDS family
ES969_09035	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ES969_09040	COG0750	zinc metalloprotease
ES969_09045	COG0442	prolyl-tRNA aminoacylation
ES969_09050	COG2176	DNA-directed DNA polymerase activity
ES969_09055	COG0779	Required for maturation of 30S ribosomal subunits
ES969_09060	COG0195	Participates in both transcription termination and antitermination
ES969_09065	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ES969_09070	COG1358	cellular component organization or biogenesis
ES969_09075	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ES969_09080	COG1550	Protein conserved in bacteria
ES969_09085	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ES969_09090	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ES969_09095	COG0196	riboflavin kinase activity
ES969_09100	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ES969_09105	COG1185	polyribonucleotide nucleotidyltransferase activity
ES969_09110	COG0726	polysaccharide deacetylase
ES969_09115	COG0612	Peptidase, M16
ES969_09120	COG1873	PFAM PRC-barrel domain
ES969_09125	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ES969_09130	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ES969_09135	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ES969_09140	COG0527	aspartate kinase activity
ES969_09145	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ES969_09150	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ES969_09155	COG0740	serine-type endopeptidase activity
ES969_09165	COG1674	ftsk spoiiie
ES969_09165	COG4980	gas vesicle protein
ES969_09170	COG2188	Transcriptional regulator
ES969_09175	COG2814	Major facilitator Superfamily
ES969_09180	COG0612	Peptidase, M16
ES969_09185	COG0612	Peptidase, M16
ES969_09190	COG0300	oxidoreductase activity
ES969_09205	COG1426	Protein conserved in bacteria
ES969_09210	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ES969_09215	COG1546	Belongs to the CinA family
ES969_09215	COG1058	Belongs to the CinA family
ES969_09220	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ES969_09225	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ES969_09230	COG1418	mRNA catabolic process
ES969_09235	COG1692	metallophosphoesterase
ES969_09240	COG2359	stage V sporulation protein S
ES969_09245	COG1063	alcohol dehydrogenase
ES969_09250	COG0156	8-amino-7-oxononanoate synthase activity
ES969_09255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ES969_09260	COG4550	Control of competence regulator ComK, YlbF/YmcA
ES969_09270	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ES969_09275	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ES969_09345	COG3328	transposase activity
ES969_09365	COG3226	Transcriptional regulator
ES969_09375	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES969_09380	COG1404	Belongs to the peptidase S8 family
ES969_09390	COG4195	phage-related replication protein
ES969_09395	COG1764	response to oxidative stress
ES969_09400	COG2076	Multidrug Resistance protein
ES969_09405	COG2076	Multidrug Resistance protein
ES969_09420	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ES969_09425	COG1923	regulation of RNA biosynthetic process
ES969_09440	COG1780	Probably involved in ribonucleotide reductase function
ES969_09445	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES969_09450	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES969_09455	COG4112	unkown
ES969_09460	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES969_09470	COG0464	growth
ES969_09475	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ES969_09480	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ES969_09485	COG0789	Transcriptional regulator
ES969_09490	COG0174	glutamine synthetase
ES969_09495	COG4974	Belongs to the 'phage' integrase family
ES969_09515	COG3646	Phage regulatory protein
ES969_09515	COG3645	SOS response
ES969_09680	COG5412	phage tail tape measure protein
ES969_09680	COG3953	SLT domain
ES969_09725	COG1388	LysM domain
ES969_09725	COG3409	Peptidoglycan-binding domain 1 protein
ES969_09725	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES969_09735	COG5444	nuclease activity
ES969_09790	COG4282	regulation of fungal-type cell wall biogenesis
ES969_09810	COG1525	nuclease
ES969_09815	COG2814	Major facilitator Superfamily
ES969_09820	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ES969_09835	COG0756	dUTP diphosphatase activity
ES969_09875	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ES969_09885	COG3832	glyoxalase III activity
ES969_09930	COG4195	phage-related replication protein
ES969_09940	COG0346	lactoylglutathione lyase activity
ES969_09950	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ES969_09955	COG1388	LysM domain
ES969_09960	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ES969_09965	COG4224	UPF0291 protein
ES969_09970	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ES969_09980	COG3763	UPF0154 protein
ES969_09990	COG0785	Cytochrome C biogenesis protein
ES969_09995	COG2201	protein-glutamate methylesterase activity
ES969_10000	COG4846	Membrane protein involved in cytochrome C biogenesis
ES969_10010	COG0071	Belongs to the small heat shock protein (HSP20) family
ES969_10025	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ES969_10030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES969_10050	COG0824	Thioesterase
ES969_10060	COG4841	protein insertion into membrane
ES969_10065	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ES969_10070	COG1832	CoA-binding protein
ES969_10075	COG0187	DNA topoisomerase II activity
ES969_10080	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ES969_10090	COG1115	amino acid carrier protein
ES969_10095	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ES969_10105	COG5520	Belongs to the glycosyl hydrolase 30 family
ES969_10115	COG2246	polysaccharide biosynthetic process
ES969_10125	COG0586	Pfam SNARE associated Golgi protein
ES969_10130	COG2404	hydrolase activity, acting on ester bonds
ES969_10135	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ES969_10140	COG1024	Enoyl-CoA hydratase
ES969_10145	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ES969_10150	COG0511	ligase activity, forming carbon-carbon bonds
ES969_10155	COG0439	Biotin carboxylase
ES969_10160	COG0318	PFAM AMP-dependent synthetase and ligase
ES969_10165	COG1960	acyl-CoA dehydrogenase activity
ES969_10175	COG1649	PFAM Uncharacterised BCR, COG1649
ES969_10185	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
ES969_10185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES969_10195	COG2027	D-alanyl-D-alanine carboxypeptidase
ES969_10200	COG2017	converts alpha-aldose to the beta-anomer
ES969_10205	COG0534	Mate efflux family protein
ES969_10220	COG0582	viral genome integration into host DNA
ES969_10225	COG0166	Belongs to the GPI family
ES969_10230	COG0405	Gamma-glutamyltransferase
ES969_10235	COG0583	DNA-binding transcription factor activity
ES969_10240	COG0604	alcohol dehydrogenase
ES969_10245	COG0493	'glutamate synthase
ES969_10250	COG0067	glutamate synthase
ES969_10250	COG0070	glutamate synthase
ES969_10250	COG0069	glutamate synthase activity
ES969_10255	COG0583	DNA-binding transcription factor activity
ES969_10285	COG0300	oxidoreductase activity
ES969_10290	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ES969_10300	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES969_10315	COG1131	(ABC) transporter
ES969_10325	COG2814	Major facilitator Superfamily
ES969_10335	COG2323	membrane
ES969_10340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES969_10350	COG2323	membrane
ES969_10365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES969_10400	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES969_10415	COG5278	phosphoserine phosphatase activity
ES969_10415	COG0840	transmembrane signaling receptor activity
ES969_10420	COG2368	4-hydroxyphenylacetate
ES969_10430	COG3619	membrane
ES969_10450	COG2140	Oxalate decarboxylase
ES969_10480	COG2720	vancomycin resistance protein
ES969_10490	COG3655	Transcriptional regulator
ES969_10495	COG3739	integral membrane protein
ES969_10500	COG0583	DNA-binding transcription factor activity
ES969_10505	COG0697	spore germination
ES969_10515	COG0693	protein deglycase activity
ES969_10520	COG2367	Beta-lactamase
ES969_10545	COG3848	Pyruvate phosphate dikinase
ES969_10545	COG0574	Belongs to the PEP-utilizing enzyme family
ES969_10550	COG0726	polysaccharide deacetylase
ES969_10560	COG2314	TM2 domain
ES969_10565	COG1396	sequence-specific DNA binding
ES969_10640	COG3655	Transcriptional regulator
ES969_10685	COG0457	Tetratricopeptide repeat
ES969_10690	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES969_10700	COG3328	transposase activity
ES969_10725	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ES969_10730	COG2226	methyltransferase
ES969_10735	COG2211	Major facilitator Superfamily
ES969_10740	COG3328	transposase activity
ES969_10785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES969_10805	COG5444	nuclease activity
ES969_10810	COG4282	regulation of fungal-type cell wall biogenesis
ES969_10815	COG1231	oxidoreductase activity
ES969_10820	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES969_10825	COG0662	Cupin 2, conserved barrel domain protein
ES969_10825	COG2207	Transcriptional regulator
ES969_10830	COG0456	acetyltransferase
ES969_10835	COG1309	transcriptional regulator
ES969_10840	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES969_10845	COG3708	Transcriptional regulator
ES969_10850	COG2378	regulation of single-species biofilm formation
ES969_10860	COG0640	Transcriptional regulator
ES969_10865	COG0741	lytic transglycosylase activity
ES969_10870	COG2322	membrane
ES969_10885	COG1619	proteins homologs of microcin C7 resistance protein MccF
ES969_10890	COG3239	Fatty acid desaturase
ES969_10895	COG4585	Histidine kinase
ES969_10900	COG2197	response regulator
ES969_10905	COG1388	LysM domain
ES969_10905	COG3584	3D domain protein
ES969_10910	COG0514	ATP-dependent DNA helicase (RecQ)
ES969_10925	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ES969_10930	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES969_10945	COG0071	Belongs to the small heat shock protein (HSP20) family
ES969_10970	COG1012	belongs to the aldehyde dehydrogenase family
ES969_10975	COG1657	PFAM Prenyltransferase squalene oxidase
ES969_10980	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ES969_10985	COG0733	neurotransmitter:sodium symporter activity
ES969_10990	COG0385	Bile acid
ES969_10995	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES969_11000	COG0567	Dehydrogenase, E1 component
ES969_11005	COG4548	von Willebrand factor, type A
ES969_11010	COG0714	Associated with various cellular activities
ES969_11015	COG2032	superoxide dismutase activity
ES969_11020	COG1388	LysM domain
ES969_11020	COG0791	NLP P60 protein
ES969_11025	COG1819	glycosyl
ES969_11030	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ES969_11035	COG0534	Mate efflux family protein
ES969_11040	COG1366	Belongs to the anti-sigma-factor antagonist family
ES969_11045	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES969_11050	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES969_11060	COG2962	Rard protein
ES969_11080	COG1942	4-Oxalocrotonate Tautomerase
ES969_11085	COG1733	regulation of RNA biosynthetic process
ES969_11090	COG0778	Nitroreductase
ES969_11095	COG0400	carboxylic ester hydrolase activity
ES969_11100	COG0346	lactoylglutathione lyase activity
ES969_11110	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES969_11120	COG3409	Peptidoglycan-binding domain 1 protein
ES969_11120	COG0793	Belongs to the peptidase S41A family
ES969_11125	COG2226	methyltransferase
ES969_11135	COG1876	peptidase activity
ES969_11140	COG0813	purine-nucleoside phosphorylase activity
ES969_11155	COG0671	phosphoesterase, PA-phosphatase related
ES969_11180	COG4479	Belongs to the UPF0346 family
ES969_11190	COG1509	lysine 2,3-aminomutase activity
ES969_11195	COG0456	acetyltransferase
ES969_11200	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES969_11205	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ES969_11210	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ES969_11215	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES969_11230	COG0456	acetyltransferase
ES969_11235	COG0463	Glycosyl transferase, family 2
ES969_11250	COG4641	Protein conserved in bacteria
ES969_11255	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
ES969_11260	COG1086	Polysaccharide biosynthesis protein
ES969_11265	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ES969_11270	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ES969_11275	COG1846	Transcriptional regulator
ES969_11280	COG0534	Mate efflux family protein
ES969_11290	COG4698	Protein conserved in bacteria
ES969_11295	COG2755	lipolytic protein G-D-S-L family
ES969_11300	COG1999	signal sequence binding
ES969_11310	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ES969_11315	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ES969_11320	COG1272	protein, Hemolysin III
ES969_11325	COG0204	Acyl-transferase
ES969_11330	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ES969_11335	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ES969_11345	COG2136	Putative SAM-dependent methyltransferase
ES969_11345	COG2521	methyltransferase
ES969_11355	COG0129	dihydroxy-acid dehydratase activity
ES969_11360	COG1413	lyase activity
ES969_11365	COG1418	mRNA catabolic process
ES969_11370	COG0386	Belongs to the glutathione peroxidase family
ES969_11375	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ES969_11380	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ES969_11390	COG1278	Cold shock
ES969_11410	COG0328	RNA-DNA hybrid ribonuclease activity
ES969_11415	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ES969_11420	COG0328	RNA-DNA hybrid ribonuclease activity
ES969_11430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES969_11445	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ES969_11455	COG1755	Isoprenylcysteine carboxyl methyltransferase
ES969_11465	COG2233	PERMEase
ES969_11470	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ES969_11475	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ES969_11485	COG0800	Aldolase
ES969_11490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES969_11495	COG1609	Transcriptional regulator
ES969_11500	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ES969_11505	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_11510	COG1199	ATP-dependent helicase activity
ES969_11525	COG0116	Belongs to the methyltransferase superfamily
ES969_11540	COG4474	Belongs to the UPF0398 family
ES969_11555	COG3359	exonuclease
ES969_11560	COG1111	helicase
ES969_11560	COG1205	dead DEAH box helicase
ES969_11565	COG2190	(PTS) system
ES969_11570	COG0071	Belongs to the small heat shock protein (HSP20) family
ES969_11605	COG3331	DNA recombination
ES969_11610	COG4499	WXG100 protein secretion system (Wss), protein YukC
ES969_11610	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES969_11620	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ES969_11625	COG3935	DnaD domain protein
ES969_11630	COG0017	Asparaginyl-tRNA synthetase
ES969_11635	COG0436	Aminotransferase
ES969_11640	COG5353	protein conserved in bacteria
ES969_11650	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ES969_11650	COG1199	ATP-dependent helicase activity
ES969_11655	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ES969_11660	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ES969_11665	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ES969_11670	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ES969_11670	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ES969_11675	COG0617	tRNA 3'-terminal CCA addition
ES969_11680	COG0438	transferase activity, transferring glycosyl groups
ES969_11685	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES969_11690	COG1803	Methylglyoxal synthase
ES969_11695	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ES969_11700	COG1694	Mazg nucleotide pyrophosphohydrolase
ES969_11705	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES969_11715	COG4347	Protein of unknown function (DUF1405)
ES969_11720	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ES969_11720	COG2010	Cytochrome c
ES969_11725	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ES969_11730	COG0723	plastoquinol--plastocyanin reductase activity
ES969_11740	COG5582	Belongs to the UPF0302 family
ES969_11745	COG0457	Tetratricopeptide repeat
ES969_11750	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ES969_11755	COG0287	Prephenate dehydrogenase
ES969_11770	COG0133	tryptophan synthase activity
ES969_11775	COG0135	phosphoribosylanthranilate isomerase activity
ES969_11785	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ES969_11790	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ES969_11795	COG4401	Chorismate mutase type I
ES969_11800	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ES969_11805	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ES969_11810	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ES969_11815	COG0105	UTP biosynthetic process
ES969_11820	COG0142	geranyltranstransferase activity
ES969_11825	COG2226	methyltransferase
ES969_11830	COG0142	geranyltranstransferase activity
ES969_11840	COG0302	gtp cyclohydrolase
ES969_11845	COG0776	regulation of translation
ES969_11850	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ES969_11865	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ES969_11870	COG1160	GTP binding
ES969_11900	COG1304	FMN binding
ES969_11905	COG0539	negative regulation of cytoplasmic translation
ES969_11910	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ES969_11920	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
ES969_11925	COG2959	enzyme of heme biosynthesis
ES969_11930	COG3409	Peptidoglycan-binding domain 1 protein
ES969_11930	COG3773	Cell wall hydrolase
ES969_11935	COG2339	peptidase activity
ES969_11940	COG0492	ferredoxin-NADP+ reductase activity
ES969_11945	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES969_11950	COG4862	establishment of competence for transformation
ES969_11955	COG1408	metallophosphoesterase
ES969_11965	COG1388	LysM domain
ES969_11970	COG1266	CAAX protease self-immunity
ES969_11975	COG0514	ATP-dependent DNA helicase (RecQ)
ES969_11980	COG4955	Helix-turn-helix domain
ES969_11985	COG1141	Ferredoxin
ES969_11990	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ES969_11995	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ES969_12000	COG0710	3-dehydroquinate dehydratase activity
ES969_12010	COG1595	DNA-templated transcription, initiation
ES969_12015	COG5002	protein histidine kinase activity
ES969_12020	COG0745	RESPONSE REGULATOR receiver
ES969_12025	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ES969_12030	COG1333	cytochrome c biogenesis protein
ES969_12035	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES969_12040	COG1187	pseudouridine synthase activity
ES969_12045	COG0700	Nucleoside recognition
ES969_12050	COG2715	membrane protein required for spore maturation
ES969_12055	COG1686	Belongs to the peptidase S11 family
ES969_12065	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ES969_12070	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ES969_12075	COG1547	Domain of unknown function (DUF309)
ES969_12080	COG0456	acetyltransferase
ES969_12085	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ES969_12090	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ES969_12090	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ES969_12095	COG0307	riboflavin synthase, alpha
ES969_12100	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ES969_12100	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ES969_12110	COG0681	Belongs to the peptidase S26 family
ES969_12115	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
ES969_12165	COG3328	transposase activity
ES969_12175	COG3012	SEC-C Motif Domain Protein
ES969_12185	COG0457	Tetratricopeptide repeat
ES969_12195	COG3328	transposase activity
ES969_12250	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ES969_12265	COG4086	secreted protein
ES969_12270	COG0019	diaminopimelate decarboxylase activity
ES969_12275	COG0697	spore germination
ES969_12290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES969_12310	COG1191	sigma factor activity
ES969_12315	COG2172	sigma factor antagonist activity
ES969_12320	COG1366	Belongs to the anti-sigma-factor antagonist family
ES969_12325	COG1686	Belongs to the peptidase S11 family
ES969_12330	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ES969_12335	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ES969_12340	COG4974	Belongs to the 'phage' integrase family
ES969_12350	COG0735	belongs to the Fur family
ES969_12355	COG1300	Membrane
ES969_12365	COG0281	malic enzyme
ES969_12370	COG1757	Na H antiporter
ES969_12375	COG1027	Aspartate ammonia-lyase
ES969_12380	COG0252	asparaginase activity
ES969_12385	COG1396	sequence-specific DNA binding
ES969_12390	COG1379	DNA repair
ES969_12395	COG0494	nUDIX hydrolase
ES969_12405	COG0667	Aldo Keto reductase
ES969_12415	COG1073	alpha beta
ES969_12425	COG4918	Iron-sulphur cluster biosynthesis
ES969_12430	COG0456	acetyltransferase
ES969_12430	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ES969_12435	COG2329	Antibiotic biosynthesis monooxygenase
ES969_12440	COG0456	acetyltransferase
ES969_12450	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ES969_12460	COG2211	Major facilitator Superfamily
ES969_12465	COG0346	lactoylglutathione lyase activity
ES969_12470	COG1072	(Pantothenic acid kinase))
ES969_12475	COG3048	D-serine ammonia-lyase activity
ES969_12480	COG0300	oxidoreductase activity
ES969_12485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES969_12490	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES969_12495	COG4187	Peptidase family M20/M25/M40
ES969_12500	COG1902	pentaerythritol trinitrate reductase activity
ES969_12505	COG0596	Alpha beta hydrolase
ES969_12515	COG1234	tRNA 3'-trailer cleavage
ES969_12520	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ES969_12525	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ES969_12530	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ES969_12540	COG0706	membrane insertase activity
ES969_12545	COG3361	conserved protein (COG2071)
ES969_12550	COG2195	Cleaves the N-terminal amino acid of tripeptides
ES969_12555	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ES969_12560	COG0346	lactoylglutathione lyase activity
ES969_12565	COG1376	ErfK ybiS ycfS ynhG family protein
ES969_12570	COG4129	membrane
ES969_12575	COG1126	abc transporter atp-binding protein
ES969_12580	COG0765	amino acid transport
ES969_12585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES969_12595	COG1597	lipid kinase activity
ES969_12605	COG4978	Transcriptional regulator
ES969_12605	COG0789	Transcriptional regulator
ES969_12610	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES969_12615	COG0022	dehydrogenase e1 component
ES969_12620	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES969_12625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES969_12630	COG3426	butyrate kinase activity
ES969_12635	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES969_12640	COG0280	phosphate acetyltransferase
ES969_12645	COG3290	protein histidine kinase activity
ES969_12645	COG3829	transcription factor binding
ES969_12655	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ES969_12660	COG2079	MmgE PrpD family protein
ES969_12665	COG0372	Belongs to the citrate synthase family
ES969_12675	COG1250	3-hydroxyacyl-CoA dehydrogenase
ES969_12680	COG0183	Belongs to the thiolase family
ES969_12685	COG0584	glycerophosphoryl diester phosphodiesterase
ES969_12690	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES969_12705	COG1902	pentaerythritol trinitrate reductase activity
ES969_12710	COG0745	RESPONSE REGULATOR receiver
ES969_12720	COG0750	zinc metalloprotease
ES969_12725	COG0497	DNA recombination
ES969_12730	COG1438	arginine binding
ES969_12735	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ES969_12740	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ES969_12745	COG0142	geranyltranstransferase activity
ES969_12750	COG1722	exodeoxyribonuclease VII activity
ES969_12755	COG1570	exodeoxyribonuclease VII activity
ES969_12760	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ES969_12765	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ES969_12770	COG1302	Protein conserved in bacteria
ES969_12775	COG0439	Biotin carboxylase
ES969_12780	COG0511	ligase activity, forming carbon-carbon bonds
ES969_12820	COG3854	ATPases associated with a variety of cellular activities
ES969_12830	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ES969_12835	COG0006	proline dipeptidase activity
ES969_12840	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ES969_12850	COG3872	metal-dependent enzyme
ES969_12860	COG1752	Esterase of the alpha-beta hydrolase superfamily
ES969_12865	COG1321	iron dependent repressor
ES969_12870	COG0095	Lipoate-protein ligase
ES969_12875	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ES969_12880	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ES969_12885	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ES969_12890	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ES969_12895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ES969_12910	COG1396	sequence-specific DNA binding
ES969_12920	COG0681	Belongs to the peptidase S26 family
ES969_12945	COG4940	Competence protein ComGF
ES969_12955	COG4970	Tfp pilus assembly protein FimT
ES969_12960	COG4537	Required for transformation and DNA binding
ES969_12965	COG1459	type II secretion system
ES969_12970	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ES969_12975	COG0517	IMP dehydrogenase activity
ES969_12980	COG0598	Magnesium transport protein CorA
ES969_12985	COG1253	flavin adenine dinucleotide binding
ES969_12990	COG1366	Belongs to the anti-sigma-factor antagonist family
ES969_13000	COG1393	Belongs to the ArsC family
ES969_13010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES969_13020	COG0011	TIGRFAM Protein of
ES969_13030	COG2866	Carboxypeptidase
ES969_13035	COG1368	sulfuric ester hydrolase activity
ES969_13040	COG1940	carbohydrate kinase activity
ES969_13045	COG4483	Protein conserved in bacteria
ES969_13050	COG0457	Tetratricopeptide repeat
ES969_13050	COG0705	Rhomboid family
ES969_13060	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ES969_13065	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ES969_13070	COG0438	transferase activity, transferring glycosyl groups
ES969_13085	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ES969_13090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES969_13095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES969_13100	COG0581	inorganic phosphate transmembrane transporter activity
ES969_13105	COG0573	inorganic phosphate transmembrane transporter activity
ES969_13110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ES969_13120	COG0477	Major facilitator Superfamily
ES969_13125	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ES969_13130	COG2839	Protein conserved in bacteria
ES969_13135	COG5521	maltodextrose utilization protein MalA
ES969_13140	COG1388	LysM domain
ES969_13145	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ES969_13150	COG4709	membrane
ES969_13155	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
ES969_13160	COG0735	belongs to the Fur family
ES969_13165	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES969_13175	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ES969_13180	COG0513	Belongs to the DEAD box helicase family
ES969_13190	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ES969_13195	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ES969_13200	COG2384	SAM-dependent methyltransferase
ES969_13205	COG2010	Cytochrome c
ES969_13215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ES969_13220	COG0358	DNA primase activity
ES969_13225	COG1671	Belongs to the UPF0178 family
ES969_13230	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ES969_13235	COG0517	IMP dehydrogenase activity
ES969_13240	COG0751	glycine-tRNA ligase activity
ES969_13245	COG0752	glycyl-tRNA synthetase alpha subunit
ES969_13250	COG1381	Involved in DNA repair and RecF pathway recombination
ES969_13260	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ES969_13265	COG0295	cytidine deaminase activity
ES969_13270	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ES969_13275	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ES969_13280	COG1480	7TM receptor with intracellular HD hydrolase
ES969_13285	COG1702	phosphate starvation-inducible protein PhoH
ES969_13290	COG0561	phosphatase activity
ES969_13305	COG4864	UPF0365 protein
ES969_13310	COG1030	water channel activity
ES969_13315	COG1610	YqeY-like protein
ES969_13320	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ES969_13325	COG1283	sodium-dependent phosphate transmembrane transporter activity
ES969_13330	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ES969_13335	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ES969_13340	COG2264	protein methyltransferase activity
ES969_13345	COG0484	heat shock protein binding
ES969_13350	COG0443	Heat shock 70 kDa protein
ES969_13355	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ES969_13360	COG1420	regulation of RNA biosynthetic process
ES969_13365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ES969_13370	COG0481	GTPase activity
ES969_13380	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES969_13385	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ES969_13390	COG0268	Binds directly to 16S ribosomal RNA
ES969_13395	COG1466	dna polymerase III delta subunit
ES969_13410	COG2333	competence protein COMEC
ES969_13410	COG0658	competence protein
ES969_13415	COG2131	deaminase
ES969_13420	COG1555	photosystem II stabilization
ES969_13420	COG1596	polysaccharide export
ES969_13425	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES969_13430	COG2226	methyltransferase
ES969_13435	COG0799	negative regulation of ribosome biogenesis
ES969_13440	COG1713	HD superfamily hydrolase involved in NAD metabolism
ES969_13445	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ES969_13450	COG1534	Rna-binding protein
ES969_13455	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ES969_13460	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ES969_13465	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ES969_13475	COG2755	lipolytic protein G-D-S-L family
ES969_13480	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES969_13480	COG3409	Peptidoglycan-binding domain 1 protein
ES969_13490	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ES969_13500	COG3209	COG3209 Rhs family protein
ES969_13520	COG0114	fumarate hydratase activity
ES969_13525	COG0583	DNA-binding transcription factor activity
ES969_13540	COG0457	Tetratricopeptide repeat
ES969_13665	COG4978	Transcriptional regulator
ES969_13665	COG0789	Transcriptional regulator
ES969_13670	COG2814	Major facilitator Superfamily
ES969_13675	COG0456	acetyltransferase
ES969_13680	COG3328	transposase activity
ES969_13690	COG1253	flavin adenine dinucleotide binding
ES969_13700	COG0697	spore germination
ES969_13705	COG0583	DNA-binding transcription factor activity
ES969_13710	COG2072	flavoprotein involved in K transport
ES969_13715	COG1230	cation diffusion facilitator family transporter
ES969_13725	COG1114	Component of the transport system for branched-chain amino acids
ES969_13730	COG1687	branched-chain amino acid
ES969_13735	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ES969_13740	COG1522	sequence-specific DNA binding
ES969_13745	COG2732	(Barnase) inhibitor
ES969_13750	COG2124	cytochrome p450
ES969_13760	COG1335	isochorismatase
ES969_13775	COG2318	DinB family
ES969_13785	COG2070	2-Nitropropane dioxygenase
ES969_13800	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ES969_13820	COG3443	Belongs to the bacterial solute-binding protein 9 family
ES969_13830	COG0667	Aldo Keto reductase
ES969_13835	COG3409	Peptidoglycan-binding domain 1 protein
ES969_13840	COG5566	PFAM Mor transcription activator
ES969_13845	COG0596	Alpha beta hydrolase
ES969_13850	COG4991	sh3 domain protein
ES969_13855	COG4991	sh3 domain protein
ES969_13865	COG0346	lactoylglutathione lyase activity
ES969_13875	COG5577	PFAM Coat F domain
ES969_13880	COG1063	alcohol dehydrogenase
ES969_13890	COG5577	PFAM Coat F domain
ES969_13895	COG0789	Transcriptional regulator
ES969_13905	COG1064	alcohol dehydrogenase
ES969_13910	COG0693	protein deglycase activity
ES969_13915	COG1621	beta-fructofuranosidase activity
ES969_13920	COG3716	PTS system mannose fructose sorbose family IID component
ES969_13925	COG3715	PTS system
ES969_13930	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES969_13935	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES969_13940	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ES969_13940	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ES969_13950	COG1113	amino acid transport
ES969_13955	COG1280	lysine exporter protein (LysE YggA)
ES969_13960	COG1378	Sugar-specific transcriptional regulator TrmB
ES969_13965	COG1595	DNA-templated transcription, initiation
ES969_13975	COG2755	lipolytic protein G-D-S-L family
ES969_13975	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ES969_13985	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ES969_13985	COG2124	cytochrome p450
ES969_13990	COG1309	transcriptional regulator
ES969_13995	COG2226	methyltransferase
ES969_14010	COG2116	formate transmembrane transporter activity
ES969_14015	COG5609	conserved protein (DUF2294)
ES969_14020	COG3383	formate dehydrogenase (NAD+) activity
ES969_14025	COG2427	Protein of unknown function (DUF1641)
ES969_14035	COG0626	cystathionine gamma-synthase activity
ES969_14040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES969_14045	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ES969_14050	COG2226	methyltransferase
ES969_14065	COG0768	penicillin binding
ES969_14070	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ES969_14075	COG0572	uridine kinase
ES969_14095	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ES969_14100	COG3906	Belongs to the UPF0473 family
ES969_14105	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ES969_14110	COG4472	Bacterial protein of unknown function (DUF965)
ES969_14115	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ES969_14120	COG0628	permease
ES969_14125	COG1126	abc transporter atp-binding protein
ES969_14130	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES969_14135	COG0765	amino acid transport
ES969_14140	COG0765	amino acid transport
ES969_14155	COG3881	PFAM PRC-barrel domain
ES969_14160	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ES969_14165	COG0457	Tetratricopeptide repeat
ES969_14170	COG0482	sulfurtransferase activity
ES969_14175	COG1104	cysteine desulfurase activity
ES969_14180	COG1959	2 iron, 2 sulfur cluster binding
ES969_14185	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ES969_14190	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ES969_14200	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ES969_14205	COG0124	histidyl-tRNA synthetase
ES969_14215	COG3103	Sh3 type 3 domain protein
ES969_14215	COG4991	sh3 domain protein
ES969_14215	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES969_14220	COG1490	D-aminoacyl-tRNA deacylase activity
ES969_14225	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ES969_14230	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ES969_14235	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ES969_14235	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ES969_14240	COG5416	Lipopolysaccharide assembly protein A domain
ES969_14245	COG0490	domain, Protein
ES969_14250	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ES969_14250	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ES969_14260	COG2244	polysaccharide biosynthetic process
ES969_14265	COG2323	membrane
ES969_14275	COG1862	Preprotein translocase
ES969_14280	COG0343	queuine tRNA-ribosyltransferase activity
ES969_14285	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ES969_14295	COG2255	four-way junction helicase activity
ES969_14300	COG0632	four-way junction helicase activity
ES969_14310	COG2814	Major facilitator Superfamily
ES969_14315	COG0673	inositol 2-dehydrogenase activity
ES969_14320	COG2112	serine threonine protein kinase
ES969_14340	COG1115	amino acid carrier protein
ES969_14345	COG0217	transcriptional regulatory protein
ES969_14355	COG1388	LysM domain
ES969_14360	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ES969_14365	COG0157	Belongs to the NadC ModD family
ES969_14370	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ES969_14375	COG1104	cysteine desulfurase activity
ES969_14380	COG1827	regulation of RNA biosynthetic process
ES969_14385	COG0077	Prephenate dehydratase
ES969_14390	COG4492	Belongs to the UPF0735 family
ES969_14395	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ES969_14400	COG3290	protein histidine kinase activity
ES969_14410	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ES969_14415	COG2868	ribosomal protein
ES969_14420	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ES969_14425	COG1994	Peptidase M50
ES969_14430	COG0739	heme binding
ES969_14435	COG2894	cell division
ES969_14440	COG0850	regulation of cytokinetic process
ES969_14445	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ES969_14450	COG1792	Involved in formation and maintenance of cell shape
ES969_14455	COG1077	Cell shape determining protein MreB Mrl
ES969_14460	COG2003	Belongs to the UPF0758 family
ES969_14465	COG0424	maF-like protein
ES969_14475	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ES969_14480	COG0285	dihydrofolate synthase activity
ES969_14485	COG0525	valine-tRNA ligase activity
ES969_14495	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES969_14500	COG1388	LysM domain
ES969_14505	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ES969_14510	COG0113	porphobilinogen synthase activity
ES969_14515	COG1587	Uroporphyrinogen-III synthase
ES969_14520	COG0181	hydroxymethylbilane synthase activity
ES969_14525	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ES969_14530	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ES969_14540	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ES969_14545	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ES969_14550	COG1067	ATP-dependent peptidase activity
ES969_14550	COG0470	DNA polymerase III
ES969_14555	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ES969_14560	COG0544	peptidyl-prolyl cis-trans isomerase activity
ES969_14565	COG1477	protein flavinylation
ES969_14565	COG0457	Tetratricopeptide repeat
ES969_14570	COG0066	3-isopropylmalate dehydratase activity
ES969_14575	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ES969_14580	COG0473	3-isopropylmalate dehydrogenase activity
ES969_14585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ES969_14590	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ES969_14595	COG0440	acetolactate synthase activity
ES969_14600	COG0028	Belongs to the TPP enzyme family
ES969_14615	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
ES969_14625	COG0622	Phosphoesterase
ES969_14630	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ES969_14635	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ES969_14640	COG5401	PFAM Sporulation and spore germination
ES969_14645	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ES969_14650	COG1846	Transcriptional regulator
ES969_14655	COG2197	response regulator
ES969_14660	COG0824	Thioesterase
ES969_14665	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ES969_14670	COG1053	succinate dehydrogenase
ES969_14675	COG2009	succinate dehydrogenase
ES969_14680	COG1719	4-vinyl reductase, 4VR
ES969_14685	COG0527	aspartate kinase activity
ES969_14695	COG0322	excinuclease ABC activity
ES969_14700	COG3118	belongs to the thioredoxin family
ES969_14705	COG3534	alpha-L-arabinofuranosidase
ES969_14710	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ES969_14715	COG2086	electron transfer activity
ES969_14720	COG1024	Enoyl-CoA hydratase
ES969_14725	COG1309	transcriptional regulator
ES969_14730	COG0318	PFAM AMP-dependent synthetase and ligase
ES969_14735	COG3766	membrane
ES969_14740	COG1193	negative regulation of DNA recombination
ES969_14745	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ES969_14745	COG1796	DNA polymerase
ES969_14750	COG1286	toxin biosynthetic process
ES969_14755	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ES969_14760	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ES969_14765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES969_14765	COG0072	phenylalanine-tRNA ligase activity
ES969_14770	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ES969_14780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ES969_14790	COG3835	regulator
ES969_14795	COG0277	FAD linked oxidase domain protein
ES969_14800	COG0247	lactate metabolic process
ES969_14805	COG0346	lactoylglutathione lyase activity
ES969_14815	COG3534	alpha-L-arabinofuranosidase
ES969_14820	COG0395	ABC-type sugar transport system, permease component
ES969_14825	COG1175	transmembrane transport
ES969_14830	COG1653	transport
ES969_14835	COG0371	Dehydrogenase
ES969_14840	COG0647	UMP catabolic process
ES969_14845	COG0235	Class ii aldolase
ES969_14850	COG1069	ribulokinase activity
ES969_14855	COG2160	L-arabinose isomerase activity
ES969_14860	COG3507	Belongs to the glycosyl hydrolase 43 family
ES969_14865	COG1363	Peptidase, m42
ES969_14875	COG3326	Membrane
ES969_14880	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ES969_14885	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ES969_14890	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ES969_14900	COG1346	cytolysis
ES969_14905	COG1380	Effector of murein hydrolase LrgA
ES969_14910	COG3279	Response regulator of the LytR AlgR family
ES969_14915	COG3275	phosphorelay sensor kinase activity
ES969_14925	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ES969_14935	COG0398	Pfam SNARE associated Golgi protein
ES969_14940	COG1484	DNA-dependent DNA replication
ES969_14945	COG3611	Membrane attachment protein
ES969_14950	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ES969_14955	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ES969_14960	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ES969_14965	COG1733	regulation of RNA biosynthetic process
ES969_14970	COG2814	Major facilitator Superfamily
ES969_14975	COG0656	L-ascorbic acid biosynthetic process
ES969_14980	COG0237	dephospho-CoA kinase activity
ES969_14985	COG1971	Probably functions as a manganese efflux pump
ES969_14990	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ES969_14995	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES969_14995	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES969_15000	COG5002	protein histidine kinase activity
ES969_15005	COG0745	RESPONSE REGULATOR receiver
ES969_15010	COG0039	L-malate dehydrogenase activity
ES969_15015	COG0538	isocitrate dehydrogenase activity
ES969_15020	COG0372	Belongs to the citrate synthase family
ES969_15025	COG2707	UPF0756 membrane protein
ES969_15030	COG0628	permease
ES969_15035	COG3030	protein affecting phage T7 exclusion by the F plasmid
ES969_15040	COG0469	pyruvate kinase activity
ES969_15045	COG0205	6-phosphofructokinase activity
ES969_15050	COG0825	malonyl-CoA metabolic process
ES969_15055	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ES969_15060	COG0281	malic enzyme
ES969_15065	COG0587	DNA-directed DNA polymerase activity
ES969_15085	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ES969_15095	COG4109	DRTGG domain
ES969_15100	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ES969_15105	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_15115	COG0165	Argininosuccinate lyase
ES969_15120	COG0137	argininosuccinate synthase activity
ES969_15125	COG0521	Mo-molybdopterin cofactor biosynthetic process
ES969_15130	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ES969_15140	COG0827	DNA restriction-modification system
ES969_15145	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ES969_15150	COG3874	Sporulation protein YtfJ
ES969_15160	COG1714	RDD family
ES969_15165	COG0616	signal peptide processing
ES969_15170	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ES969_15175	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ES969_15180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ES969_15190	COG0301	tRNA thio-modification
ES969_15195	COG1104	cysteine desulfurase activity
ES969_15200	COG1114	Component of the transport system for branched-chain amino acids
ES969_15205	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ES969_15210	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ES969_15215	COG1309	transcriptional regulator
ES969_15220	COG1956	GAF domain-containing protein
ES969_15225	COG2203	Gaf domain
ES969_15225	COG2199	diguanylate cyclase activity
ES969_15235	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ES969_15240	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ES969_15250	COG0454	-acetyltransferase
ES969_15255	COG0517	IMP dehydrogenase activity
ES969_15260	COG0123	including yeast histone deacetylase and acetoin utilization protein
ES969_15265	COG1360	Flagellar Motor Protein
ES969_15270	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ES969_15275	COG1609	Transcriptional regulator
ES969_15280	COG1605	Chorismate mutase
ES969_15280	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ES969_15285	COG3118	belongs to the thioredoxin family
ES969_15290	COG4980	gas vesicle protein
ES969_15295	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ES969_15300	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ES969_15305	COG1674	ftsk spoiiie
ES969_15310	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES969_15315	COG4848	Belongs to the UPF0354 family
ES969_15320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES969_15335	COG1363	Peptidase, m42
ES969_15340	COG5584	Small secreted protein
ES969_15345	COG0281	malic enzyme
ES969_15350	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES969_15355	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ES969_15365	COG0510	thiamine kinase activity
ES969_15370	COG1523	belongs to the glycosyl hydrolase 13 family
ES969_15375	COG1597	lipid kinase activity
ES969_15385	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ES969_15390	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES969_15395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES969_15400	COG2252	PERMEase
ES969_15405	COG4473	ABC transporter
ES969_15410	COG1131	(ABC) transporter
ES969_15415	COG1349	DNA-binding transcription factor activity
ES969_15420	COG1187	pseudouridine synthase activity
ES969_15425	COG2244	polysaccharide biosynthetic process
ES969_15430	COG2081	HI0933 family
ES969_15435	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ES969_15455	COG1653	transport
ES969_15460	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ES969_15465	COG4209	transmembrane transport
ES969_15475	COG1653	transport
ES969_15480	COG0395	ABC-type sugar transport system, permease component
ES969_15485	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES969_15490	COG2124	cytochrome p450
ES969_15510	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES969_15520	COG1073	alpha beta
ES969_15545	COG1486	melibiose metabolic process
ES969_15550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ES969_15555	COG0495	leucyl-tRNA aminoacylation
ES969_15565	COG1366	Belongs to the anti-sigma-factor antagonist family
ES969_15565	COG2202	Pas domain
ES969_15570	COG2814	Major facilitator Superfamily
ES969_15575	COG2433	Pfam Transposase IS66
ES969_15585	COG0577	efflux transmembrane transporter activity
ES969_15590	COG1136	(ABC) transporter
ES969_15595	COG2205	protein histidine kinase activity
ES969_15600	COG0745	RESPONSE REGULATOR receiver
ES969_15605	COG0577	efflux transmembrane transporter activity
ES969_15610	COG1136	(ABC) transporter
ES969_15625	COG1131	(ABC) transporter
ES969_15630	COG1725	Transcriptional regulator
ES969_15645	COG1242	4 iron, 4 sulfur cluster binding
ES969_15650	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ES969_15660	COG2267	carboxylic ester hydrolase activity
ES969_15665	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ES969_15670	COG1113	amino acid transport
ES969_15675	COG0367	asparagine synthase
ES969_15680	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ES969_15685	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ES969_15695	COG1506	peptidase
ES969_15700	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ES969_15705	COG1116	anion transmembrane transporter activity
ES969_15710	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ES969_15715	COG0494	nUDIX hydrolase
ES969_15720	COG4824	toxin secretion phage lysis holin
ES969_15725	COG0783	Belongs to the Dps family
ES969_15740	COG1854	S-ribosylhomocysteine lyase activity
ES969_15745	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ES969_15750	COG0288	reversible hydration of carbon dioxide
ES969_15755	COG0254	rRNA binding
ES969_15760	COG1271	oxidase subunit
ES969_15765	COG1294	oxidase, subunit
ES969_15775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES969_15780	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES969_15780	COG1321	iron dependent repressor
ES969_15785	COG1121	(ABC) transporter
ES969_15790	COG0803	Belongs to the bacterial solute-binding protein 9 family
ES969_15795	COG4948	Mandelate Racemase Muconate Lactonizing
ES969_15800	COG0318	PFAM AMP-dependent synthetase and ligase
ES969_15805	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ES969_15810	COG0596	Alpha beta hydrolase
ES969_15815	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ES969_15820	COG1169	isochorismate synthase
ES969_15830	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES969_15835	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ES969_15840	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ES969_15845	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES969_15850	COG0438	transferase activity, transferring glycosyl groups
ES969_15860	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES969_15865	COG0438	transferase activity, transferring glycosyl groups
ES969_15870	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES969_15875	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ES969_15880	COG0058	SHG alpha-glucan phosphorylase activity
ES969_15885	COG0297	glycogen (starch) synthase activity
ES969_15890	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ES969_15895	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ES969_15900	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ES969_16025	COG3859	Proton-coupled thiamine transporter YuaJ
ES969_16030	COG1247	-acetyltransferase
ES969_16035	COG2268	Band 7 protein
ES969_16040	COG1585	Membrane protein implicated in regulation of membrane protease activity
ES969_16045	COG2318	DinB family
ES969_16055	COG1454	alcohol dehydrogenase
ES969_16065	COG1510	regulation of RNA biosynthetic process
ES969_16075	COG0569	domain protein
ES969_16080	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ES969_16085	COG4682	membrane
ES969_16090	COG1705	Flagellar rod assembly protein muramidase FlgJ
ES969_16095	COG0477	Major facilitator Superfamily
ES969_16100	COG5553	Cysteine dioxygenase type I
ES969_16110	COG1968	undecaprenyl-diphosphatase activity
ES969_16115	COG0628	permease
ES969_16120	COG0673	inositol 2-dehydrogenase activity
ES969_16125	COG4806	L-rhamnose isomerase
ES969_16130	COG3254	rhamnose metabolic process
ES969_16135	COG1070	Carbohydrate kinase
ES969_16140	COG1349	DNA-binding transcription factor activity
ES969_16145	COG3347	Dehydrogenase
ES969_16145	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_16160	COG0840	transmembrane signaling receptor activity
ES969_16165	COG0840	transmembrane signaling receptor activity
ES969_16170	COG0840	transmembrane signaling receptor activity
ES969_16185	COG0432	Pfam Uncharacterised protein family UPF0047
ES969_16195	COG0366	Alpha amylase catalytic
ES969_16200	COG1253	flavin adenine dinucleotide binding
ES969_16205	COG2738	Putative neutral zinc metallopeptidase
ES969_16220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ES969_16235	COG0166	Belongs to the GPI family
ES969_16240	COG1979	alcohol dehydrogenase
ES969_16245	COG1979	alcohol dehydrogenase
ES969_16250	COG2155	Conserved Protein
ES969_16255	COG1098	S1 RNA binding domain
ES969_16260	COG0436	Aminotransferase
ES969_16265	COG1522	sequence-specific DNA binding
ES969_16270	COG2267	carboxylic ester hydrolase activity
ES969_16280	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ES969_16285	COG2205	protein histidine kinase activity
ES969_16295	COG5018	Exonuclease
ES969_16305	COG2814	Major facilitator Superfamily
ES969_16310	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES969_16315	COG3011	Protein conserved in bacteria
ES969_16325	COG3290	protein histidine kinase activity
ES969_16330	COG4565	transcriptional regulatory protein
ES969_16355	COG3493	citrate carrier protein
ES969_16365	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ES969_16365	COG2111	Na H antiporter
ES969_16370	COG2111	Na H antiporter
ES969_16375	COG1006	Multisubunit Na H antiporter MnhC subunit
ES969_16380	COG0651	ATP synthesis coupled electron transport
ES969_16385	COG1863	multisubunit Na H antiporter MnhE subunit
ES969_16390	COG2212	antiporter activity
ES969_16395	COG1320	monovalent cation:proton antiporter activity
ES969_16400	COG2050	protein possibly involved in aromatic compounds catabolism
ES969_16405	COG2197	response regulator
ES969_16410	COG4585	Histidine kinase
ES969_16420	COG0142	geranyltranstransferase activity
ES969_16440	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ES969_16445	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ES969_16450	COG1335	isochorismatase
ES969_16455	COG5506	Protein of unknown function (DUF1694)
ES969_16470	COG0628	permease
ES969_16485	COG1418	mRNA catabolic process
ES969_16490	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_16500	COG1511	domain protein
ES969_16505	COG1674	ftsk spoiiie
ES969_16505	COG0433	COG0433 Predicted ATPase
ES969_16510	COG4499	WXG100 protein secretion system (Wss), protein YukC
ES969_16515	COG5417	Belongs to the EsaB family
ES969_16520	COG4842	Belongs to the WXG100 family
ES969_16530	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ES969_16530	COG2508	Transcriptional regulator
ES969_16535	COG0686	Belongs to the AlaDH PNT family
ES969_16540	COG5634	Uncharacterized conserved protein (DUF2278)
ES969_16545	COG3251	PFAM MbtH domain protein
ES969_16550	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES969_16555	COG1535	isochorismatase
ES969_16555	COG3433	isochorismatase activity
ES969_16560	COG1021	2,3-dihydroxybenzoate-AMP ligase
ES969_16565	COG1169	isochorismate synthase
ES969_16570	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_16575	COG2819	hydrolase of the alpha beta superfamily
ES969_16580	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ES969_16585	COG1268	BioY protein
ES969_16590	COG2056	Na+-H+ antiporter family
ES969_16595	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ES969_16600	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
ES969_16610	COG3584	3D domain protein
ES969_16625	COG1252	NADH dehydrogenase
ES969_16630	COG0492	ferredoxin-NADP+ reductase activity
ES969_16640	COG0516	GMP reductase activity
ES969_16655	COG0316	Belongs to the HesB IscA family
ES969_16660	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ES969_16665	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES969_16670	COG4844	belongs to the
ES969_16675	COG1252	NADH dehydrogenase
ES969_16680	COG4837	Protein of unknown function (DUF1462)
ES969_16685	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ES969_16690	COG0823	Involved in the tonB-independent uptake of proteins
ES969_16690	COG1506	peptidase
ES969_16690	COG4946	Tricorn protease homolog
ES969_16695	COG0083	homoserine kinase activity
ES969_16700	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ES969_16705	COG0460	homoserine dehydrogenase
ES969_16710	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES969_16715	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ES969_16720	COG0647	UMP catabolic process
ES969_16725	COG2445	Protein of unknown function DUF86
ES969_16730	COG4470	Protein conserved in bacteria
ES969_16740	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ES969_16745	COG0739	heme binding
ES969_16755	COG3377	Domain of unknown function (DUF1805)
ES969_16760	COG0737	Belongs to the 5'-nucleotidase family
ES969_16765	COG0730	response to heat
ES969_16770	COG1801	Protein of unknown function DUF72
ES969_16780	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ES969_16785	COG2508	Transcriptional regulator
ES969_16790	COG2233	PERMEase
ES969_16795	COG2233	PERMEase
ES969_16800	COG3648	Uricase
ES969_16800	COG3195	allantoin biosynthetic process
ES969_16805	COG2351	hydroxyisourate hydrolase activity
ES969_16820	COG2080	2 iron, 2 sulfur cluster binding
ES969_16825	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ES969_16830	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ES969_16840	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ES969_16845	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ES969_16850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES969_16860	COG2356	endonuclease I
ES969_16865	COG3842	ATPase activity
ES969_16870	COG2188	Transcriptional regulator
ES969_16875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES969_16880	COG0395	ABC-type sugar transport system, permease component
ES969_16885	COG1175	transmembrane transport
ES969_16890	COG1653	transport
ES969_16895	COG2222	sugar isomerase
ES969_16900	COG0322	excinuclease ABC activity
ES969_16905	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ES969_16920	COG0346	lactoylglutathione lyase activity
ES969_16925	COG0640	Transcriptional regulator
ES969_16930	COG0719	Fe-S assembly protein
ES969_16935	COG0822	iron-sulfur transferase activity
ES969_16940	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ES969_16945	COG0719	Fe-S assembly protein
ES969_16950	COG0396	ATPase activity
ES969_16965	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ES969_16970	COG1464	Belongs to the NlpA lipoprotein family
ES969_16975	COG2011	ABC-type metal ion transport system permease component
ES969_16980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ES969_16990	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES969_16995	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ES969_17005	COG0509	glycine decarboxylation via glycine cleavage system
ES969_17010	COG1393	Belongs to the ArsC family
ES969_17015	COG1960	acyl-CoA dehydrogenase activity
ES969_17020	COG0183	Belongs to the thiolase family
ES969_17025	COG1024	Enoyl-CoA hydratase
ES969_17025	COG1250	3-hydroxyacyl-CoA dehydrogenase
ES969_17035	COG0506	proline dehydrogenase activity
ES969_17045	COG5577	PFAM Coat F domain
ES969_17050	COG1846	Transcriptional regulator
ES969_17055	COG0477	Major facilitator Superfamily
ES969_17060	COG1942	4-Oxalocrotonate Tautomerase
ES969_17065	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_17070	COG0583	DNA-binding transcription factor activity
ES969_17080	COG1120	ATPase activity
ES969_17100	COG1131	(ABC) transporter
ES969_17145	COG0783	Belongs to the Dps family
ES969_17150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES969_17155	COG0745	RESPONSE REGULATOR receiver
ES969_17160	COG2770	Histidine kinase
ES969_17160	COG2205	protein histidine kinase activity
ES969_17170	COG1309	transcriptional regulator
ES969_17175	COG0114	fumarate hydratase activity
ES969_17185	COG0697	spore germination
ES969_17190	COG0814	amino acid
ES969_17200	COG2197	response regulator
ES969_17205	COG4585	Histidine kinase
ES969_17210	COG4758	membrane
ES969_17215	COG3595	metallopeptidase activity
ES969_17220	COG1842	Phage shock protein A
ES969_17225	COG4758	membrane
ES969_17230	COG2814	Major facilitator Superfamily
ES969_17235	COG2096	Adenosyltransferase
ES969_17240	COG1120	ATPase activity
ES969_17245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES969_17250	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES969_17255	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_17260	COG3386	PFAM SMP-30 Gluconolaconase
ES969_17265	COG2205	protein histidine kinase activity
ES969_17270	COG0745	RESPONSE REGULATOR receiver
ES969_17280	COG1191	sigma factor activity
ES969_17290	COG2140	Oxalate decarboxylase
ES969_17300	COG0577	efflux transmembrane transporter activity
ES969_17305	COG1136	(ABC) transporter
ES969_17310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ES969_17315	COG1120	ATPase activity
ES969_17320	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES969_17325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES969_17330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES969_17340	COG0531	amino acid
ES969_17355	COG1988	membrane-bound metal-dependent
ES969_17360	COG1368	sulfuric ester hydrolase activity
ES969_17365	COG1910	domain protein
ES969_17370	COG0725	ABC transporter, periplasmic molybdate-binding protein
ES969_17375	COG4149	molybdate abc transporter
ES969_17380	COG0656	L-ascorbic acid biosynthetic process
ES969_17390	COG0025	NhaP-type Na H and K H
ES969_17395	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ES969_17400	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ES969_17405	COG3973	AAA domain
ES969_17415	COG2860	membrane
ES969_17420	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ES969_17425	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ES969_17430	COG2217	Heavy metal translocating P-type atpase
ES969_17435	COG2217	Heavy metal translocating P-type atpase
ES969_17440	COG2608	mercury ion transmembrane transporter activity
ES969_17445	COG1937	Protein conserved in bacteria
ES969_17450	COG0673	inositol 2-dehydrogenase activity
ES969_17460	COG1289	transmembrane transporter activity
ES969_17470	COG2076	Multidrug Resistance protein
ES969_17475	COG1309	transcriptional regulator
ES969_17480	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_17490	COG5444	nuclease activity
ES969_17505	COG3409	Peptidoglycan-binding domain 1 protein
ES969_17505	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES969_17510	COG4824	toxin secretion phage lysis holin
ES969_17535	COG1705	Flagellar rod assembly protein muramidase FlgJ
ES969_17535	COG3942	CHAP domain
ES969_17760	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ES969_17765	COG0557	exoribonuclease II activity
ES969_17770	COG1647	Serine aminopeptidase, S33
ES969_17775	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ES969_17780	COG0596	Alpha beta hydrolase
ES969_17785	COG1476	TRANSCRIPTIONal
ES969_17790	COG1396	sequence-specific DNA binding
ES969_17795	COG1396	sequence-specific DNA binding
ES969_17800	COG1733	regulation of RNA biosynthetic process
ES969_17805	COG0840	transmembrane signaling receptor activity
ES969_17810	COG1174	glycine betaine transport
ES969_17815	COG1732	Glycine betaine
ES969_17820	COG1174	glycine betaine transport
ES969_17825	COG1125	glycine betaine transport
ES969_17825	COG0517	IMP dehydrogenase activity
ES969_17830	COG1510	regulation of RNA biosynthetic process
ES969_17835	COG1174	glycine betaine transport
ES969_17840	COG1732	Glycine betaine
ES969_17845	COG1174	glycine betaine transport
ES969_17850	COG1125	glycine betaine transport
ES969_17850	COG0517	IMP dehydrogenase activity
ES969_17855	COG1510	regulation of RNA biosynthetic process
ES969_17860	COG2095	MarC family integral membrane protein
ES969_17870	COG3064	Membrane
ES969_17875	COG4640	response to antibiotic
ES969_17880	COG0456	acetyltransferase
ES969_17885	COG0148	phosphopyruvate hydratase activity
ES969_17890	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ES969_17895	COG0149	triose-phosphate isomerase activity
ES969_17900	COG0126	phosphoglycerate kinase activity
ES969_17905	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ES969_17910	COG2390	Transcriptional regulator
ES969_17915	COG2814	Major facilitator Superfamily
ES969_17920	COG1609	Transcriptional regulator
ES969_17925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES969_17935	COG0583	DNA-binding transcription factor activity
ES969_17940	COG0697	spore germination
ES969_17950	COG1113	amino acid transport
ES969_17960	COG1556	Lactate utilization protein
ES969_17965	COG1139	Iron-sulfur cluster binding protein
ES969_17970	COG0247	lactate metabolic process
ES969_17975	COG2197	response regulator
ES969_17980	COG4585	Histidine kinase
ES969_17985	COG0842	Transport permease protein
ES969_17990	COG1131	(ABC) transporter
ES969_17995	COG0596	Alpha beta hydrolase
ES969_18000	COG2208	phosphoserine phosphatase activity
ES969_18005	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ES969_18010	COG1874	Beta-galactosidase
ES969_18015	COG3833	ABC-type maltose transport systems, permease component
ES969_18020	COG1175	transmembrane transport
ES969_18025	COG2182	Extracellular solute-binding protein
ES969_18030	COG1609	Transcriptional regulator
ES969_18035	COG2186	Transcriptional regulator
ES969_18040	COG1620	l-lactate permease
ES969_18045	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ES969_18055	COG5039	Polysaccharide pyruvyl transferase
ES969_18060	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES969_18065	COG0110	maltose O-acetyltransferase activity
ES969_18070	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ES969_18075	COG2244	polysaccharide biosynthetic process
ES969_18080	COG1216	Glycosyl transferase, family 2
ES969_18085	COG5039	Polysaccharide pyruvyl transferase
ES969_18090	COG1216	Glycosyl transferase, family 2
ES969_18100	COG0438	transferase activity, transferring glycosyl groups
ES969_18105	COG1215	transferase activity, transferring glycosyl groups
ES969_18110	COG0438	transferase activity, transferring glycosyl groups
ES969_18115	COG1086	Polysaccharide biosynthesis protein
ES969_18120	COG0489	protein tyrosine kinase activity
ES969_18125	COG3944	biosynthesis protein
ES969_18130	COG1396	sequence-specific DNA binding
ES969_18135	COG2272	Belongs to the type-B carboxylesterase lipase family
ES969_18145	COG3479	Phenolic acid decarboxylase
ES969_18160	COG1794	racemase activity, acting on amino acids and derivatives
ES969_18170	COG1621	beta-fructofuranosidase activity
ES969_18175	COG1621	beta-fructofuranosidase activity
ES969_18180	COG0531	amino acid
ES969_18185	COG1309	transcriptional regulator
ES969_18190	COG2076	Multidrug Resistance protein
ES969_18195	COG2076	Multidrug Resistance protein
ES969_18210	COG0740	serine-type endopeptidase activity
ES969_18215	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ES969_18220	COG0366	Alpha amylase catalytic
ES969_18225	COG1554	hydrolase, family 65, central catalytic
ES969_18230	COG5521	maltodextrose utilization protein MalA
ES969_18235	COG3833	ABC-type maltose transport systems, permease component
ES969_18240	COG1175	transmembrane transport
ES969_18255	COG1609	Transcriptional regulator
ES969_18260	COG1611	Belongs to the LOG family
ES969_18270	COG0659	secondary active sulfate transmembrane transporter activity
ES969_18275	COG0288	reversible hydration of carbon dioxide
ES969_18280	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ES969_18285	COG0577	efflux transmembrane transporter activity
ES969_18290	COG1136	(ABC) transporter
ES969_18295	COG5002	protein histidine kinase activity
ES969_18300	COG0745	RESPONSE REGULATOR receiver
ES969_18310	COG2162	N-hydroxyarylamine O-acetyltransferase activity
ES969_18315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES969_18320	COG1481	regulation of sporulation
ES969_18325	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ES969_18330	COG1660	Displays ATPase and GTPase activities
ES969_18335	COG1051	belongs to the nudix hydrolase family
ES969_18340	COG0492	ferredoxin-NADP+ reductase activity
ES969_18345	COG3883	PFAM NLP P60 protein
ES969_18345	COG0791	NLP P60 protein
ES969_18350	COG0457	Tetratricopeptide repeat
ES969_18355	COG1132	(ABC) transporter
ES969_18375	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ES969_18375	COG0140	phosphoribosyl-ATP diphosphatase activity
ES969_18380	COG0107	imidazoleglycerol-phosphate synthase activity
ES969_18385	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ES969_18390	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ES969_18395	COG0131	Imidazoleglycerol-phosphate dehydratase
ES969_18400	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ES969_18405	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ES969_18410	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ES969_18415	COG4990	cell redox homeostasis
ES969_18420	COG5297	Belongs to the glycosyl hydrolase family 6
ES969_18425	COG0110	maltose O-acetyltransferase activity
ES969_18430	COG0546	phosphoglycolate phosphatase activity
ES969_18435	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ES969_18440	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ES969_18445	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ES969_18450	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ES969_18455	COG0363	glucosamine-6-phosphate deaminase activity
ES969_18465	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ES969_18470	COG1950	PFAM Membrane protein of
ES969_18475	COG1983	PspC domain protein
ES969_18480	COG3595	metallopeptidase activity
ES969_18495	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ES969_18500	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ES969_18505	COG0556	nucleotide-excision repair
ES969_18510	COG4897	Protein conserved in bacteria
ES969_18515	COG3848	Pyruvate phosphate dikinase
ES969_18515	COG0574	Belongs to the PEP-utilizing enzyme family
ES969_18525	COG2814	Major facilitator Superfamily
ES969_18530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES969_18540	COG3409	Peptidoglycan-binding domain 1 protein
ES969_18540	COG0793	Belongs to the peptidase S41A family
ES969_18545	COG2177	Part of the ABC transporter FtsEX involved in
ES969_18550	COG2884	Cell division ATP-binding protein ftsE
ES969_18555	COG2010	Cytochrome c
ES969_18560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES969_18570	COG0653	protein targeting
ES969_18580	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ES969_18595	COG1516	flagellar protein fliS
ES969_18600	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ES969_18605	COG1334	flagellar protein FlaG
ES969_18610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ES969_18615	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ES969_18620	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ES969_18630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ES969_18635	COG1256	bacterial-type flagellum assembly
ES969_18635	COG4786	Flagellar basal body rod
ES969_18640	COG3418	PFAM FlgN family protein
ES969_18645	COG2747	anti-sigma28 factor FlgM
ES969_18655	COG1040	competence protein
ES969_18665	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ES969_18670	COG1307	EDD domain protein, DegV family
ES969_18675	COG2197	response regulator
ES969_18680	COG4585	Histidine kinase
ES969_18685	COG1739	Uncharacterized protein family UPF0029
ES969_18690	COG1316	TRANSCRIPTIONal
ES969_18725	COG1131	(ABC) transporter
ES969_18735	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ES969_18740	COG0438	transferase activity, transferring glycosyl groups
ES969_18745	COG1215	transferase activity, transferring glycosyl groups
ES969_18750	COG3206	protein involved in exopolysaccharide biosynthesis
ES969_18755	COG3307	-O-antigen
ES969_18765	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ES969_18770	COG0297	glycogen (starch) synthase activity
ES969_18770	COG0438	transferase activity, transferring glycosyl groups
ES969_18775	COG2244	polysaccharide biosynthetic process
ES969_18785	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES969_18785	COG2247	cell wall binding repeat
ES969_18790	COG2247	cell wall binding repeat
ES969_18790	COG2385	sporulation resulting in formation of a cellular spore
ES969_18805	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ES969_18810	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ES969_18820	COG1134	teichoic acid transport
ES969_18825	COG1682	transport, permease protein
ES969_18840	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES969_18840	COG0463	Glycosyl transferase, family 2
ES969_18845	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES969_18850	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ES969_18855	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ES969_18860	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES969_18865	COG4193	domain, Protein
ES969_18870	COG1482	cell wall glycoprotein biosynthetic process
ES969_18875	COG0697	spore germination
ES969_18880	COG0814	amino acid
ES969_18895	COG1316	TRANSCRIPTIONal
ES969_18900	COG0561	phosphatase activity
ES969_18905	COG0791	NLP P60 protein
ES969_18915	COG2843	Capsule synthesis protein
ES969_18925	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ES969_18930	COG1609	Transcriptional regulator
ES969_18935	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES969_18940	COG1869	D-ribose catabolic process
ES969_18945	COG1129	ABC transporter
ES969_18950	COG1172	Belongs to the binding-protein-dependent transport system permease family
ES969_18955	COG1879	ABC-type sugar transport system periplasmic component
ES969_18960	COG3103	Sh3 type 3 domain protein
ES969_18970	COG2249	NAD(P)H dehydrogenase (quinone) activity
ES969_18975	COG3527	Alpha-acetolactate decarboxylase
ES969_18980	COG0028	Belongs to the TPP enzyme family
ES969_18985	COG0583	DNA-binding transcription factor activity
ES969_18990	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ES969_19005	COG5337	Spore coat protein CotH
ES969_19015	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ES969_19025	COG0405	Gamma-glutamyltransferase
ES969_19030	COG1522	sequence-specific DNA binding
ES969_19035	COG2059	Chromate
ES969_19040	COG2059	Chromate
ES969_19050	COG0655	NAD(P)H dehydrogenase (quinone) activity
ES969_19085	COG5444	nuclease activity
ES969_19110	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ES969_19115	COG4464	protein tyrosine phosphatase activity
ES969_19120	COG0489	protein tyrosine kinase activity
ES969_19125	COG3944	biosynthesis protein
ES969_19135	COG4715	Zinc finger, swim domain protein
ES969_19140	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ES969_19145	COG0561	phosphatase activity
ES969_19150	COG1349	DNA-binding transcription factor activity
ES969_19155	COG0629	single-stranded DNA binding
ES969_19170	COG3764	Sortase (surface protein transpeptidase)
ES969_19185	COG1970	mechanosensitive ion channel activity
ES969_19190	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ES969_19195	COG0457	Tetratricopeptide repeat
ES969_19200	COG4786	Flagellar basal body rod
ES969_19205	COG4786	Flagellar basal body rod
ES969_19210	COG1077	Cell shape determining protein MreB Mrl
ES969_19215	COG1609	Transcriptional regulator
ES969_19225	COG1846	Transcriptional regulator
ES969_19230	COG2814	Major facilitator Superfamily
ES969_19235	COG3420	alginic acid biosynthetic process
ES969_19240	COG1953	Uracil, thiamine, allantoin
ES969_19245	COG0477	Major facilitator Superfamily
ES969_19250	COG1335	isochorismatase
ES969_19260	COG0004	ammonium transporteR
ES969_19265	COG0347	Belongs to the P(II) protein family
ES969_19270	COG0671	phosphoesterase, PA-phosphatase related
ES969_19280	COG0739	heme binding
ES969_19285	COG1247	-acetyltransferase
ES969_19295	COG2089	acid synthase
ES969_19305	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES969_19310	COG0789	Transcriptional regulator
ES969_19320	COG2910	NAD(P)H-binding
ES969_19325	COG1959	2 iron, 2 sulfur cluster binding
ES969_19330	COG0804	urea catabolic process
ES969_19335	COG0832	Belongs to the urease beta subunit family
ES969_19340	COG0831	urea catabolic process
ES969_19355	COG3237	CsbD-like
ES969_19360	COG1994	Peptidase M50
ES969_19365	COG0457	Tetratricopeptide repeat
ES969_19370	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ES969_19375	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ES969_19385	COG2304	oxidoreductase activity
ES969_19395	COG2304	oxidoreductase activity
ES969_19400	COG2385	sporulation resulting in formation of a cellular spore
ES969_19405	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ES969_19415	COG4836	Membrane
ES969_19425	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ES969_19430	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ES969_19435	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ES969_19440	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ES969_19445	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ES969_19450	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ES969_19455	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ES969_19460	COG0356	it plays a direct role in the translocation of protons across the membrane
ES969_19470	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ES969_19475	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ES969_19480	COG4475	Protein of unknown function (DUF436)
ES969_19485	COG0698	ribose 5-phosphate isomerase
ES969_19490	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ES969_19495	COG1971	Probably functions as a manganese efflux pump
ES969_19500	COG0009	L-threonylcarbamoyladenylate synthase
ES969_19505	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ES969_19525	COG2890	protein-(glutamine-N5) methyltransferase activity
ES969_19530	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ES969_19535	COG0346	lactoylglutathione lyase activity
ES969_19540	COG0789	Transcriptional regulator
ES969_19545	COG0679	Auxin Efflux Carrier
ES969_19550	COG0281	malic enzyme
ES969_19555	COG1435	thymidine kinase activity
ES969_19560	COG0254	rRNA binding
ES969_19565	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ES969_19575	COG1494	fructose-1,6-bisphosphatase
ES969_19580	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ES969_19585	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ES969_19590	COG0191	fructose-bisphosphate aldolase activity
ES969_19595	COG2204	response regulator
ES969_19610	COG0504	CTP synthase activity
ES969_19615	COG3343	RNA polymerase activity
ES969_19620	COG1960	acyl-CoA dehydrogenase activity
ES969_19625	COG2181	nitrate reductase activity
ES969_19625	COG0247	lactate metabolic process
ES969_19630	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES969_19635	COG4294	response to UV
ES969_19650	COG0018	arginyl-trna synthetase
ES969_19655	COG4506	Protein conserved in bacteria
ES969_19670	COG0535	radical SAM domain protein
ES969_19680	COG1131	(ABC) transporter
ES969_19685	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ES969_19690	COG0612	Peptidase, M16
ES969_19695	COG0612	Peptidase, M16
ES969_19705	COG3391	amine dehydrogenase activity
ES969_19720	COG0457	Tetratricopeptide repeat
ES969_19735	COG0010	Belongs to the arginase family
ES969_19740	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ES969_19745	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES969_19760	COG1994	Peptidase M50
ES969_19765	COG1942	4-Oxalocrotonate Tautomerase
ES969_19770	COG1846	Transcriptional regulator
ES969_19775	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ES969_19785	COG0477	Major facilitator Superfamily
ES969_19790	COG1959	2 iron, 2 sulfur cluster binding
ES969_19795	COG3465	dGTPase activity
ES969_19800	COG1078	dGTPase activity
ES969_19805	COG4844	belongs to the
ES969_19815	COG0697	spore germination
ES969_19820	COG0095	Lipoate-protein ligase
ES969_19825	COG0583	DNA-binding transcription factor activity
ES969_19830	COG0280	phosphate acetyltransferase
ES969_19840	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_19845	COG0436	Aminotransferase
ES969_19850	COG2814	Major facilitator Superfamily
ES969_19855	COG0151	Belongs to the GarS family
ES969_19860	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_19865	COG1917	Cupin 2, conserved barrel domain protein
ES969_19870	COG0077	Prephenate dehydratase
ES969_19875	COG2814	Major facilitator Superfamily
ES969_19880	COG0833	amino acid
ES969_19885	COG4187	Peptidase family M20/M25/M40
ES969_19890	COG1012	belongs to the aldehyde dehydrogenase family
ES969_19895	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES969_19905	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ES969_19910	COG1091	dTDP-4-dehydrorhamnose reductase activity
ES969_19915	COG1088	dTDP-glucose 4,6-dehydratase activity
ES969_19920	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ES969_19925	COG3980	spore coat polysaccharide biosynthesis protein
ES969_19930	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
ES969_19935	COG2089	acid synthase
ES969_19940	COG0456	acetyltransferase
ES969_19945	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES969_19950	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES969_19955	COG0463	Glycosyl transferase, family 2
ES969_19970	COG2363	Small membrane protein
ES969_19975	COG2233	PERMEase
ES969_19985	COG1012	belongs to the aldehyde dehydrogenase family
ES969_19990	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ES969_19995	COG1216	Glycosyl transferase, family 2
ES969_20000	COG0351	phosphomethylpyrimidine kinase
ES969_20010	COG1621	beta-fructofuranosidase activity
ES969_20015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES969_20015	COG1263	PTS System
ES969_20020	COG2116	formate transmembrane transporter activity
ES969_20025	COG3711	transcriptional antiterminator
ES969_20035	COG1404	Belongs to the peptidase S8 family
ES969_20040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES969_20045	COG0778	Nitroreductase
ES969_20050	COG0772	Belongs to the SEDS family
ES969_20065	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ES969_20070	COG1845	cytochrome c oxidase, subunit III
ES969_20075	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ES969_20080	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ES969_20085	COG2261	transglycosylase associated protein
ES969_20090	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ES969_20095	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ES969_20100	COG2246	polysaccharide biosynthetic process
ES969_20105	COG1309	transcriptional regulator
ES969_20115	COG3162	membrane
ES969_20120	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES969_20125	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ES969_20130	COG2837	iron assimilation
ES969_20135	COG2822	iron ion transport
ES969_20140	COG0672	)-iron permease
ES969_20145	COG0352	thiamine-phosphate diphosphorylase activity
ES969_20150	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ES969_20155	COG0583	DNA-binding transcription factor activity
ES969_20160	COG1380	Effector of murein hydrolase LrgA
ES969_20165	COG1346	cytolysis
ES969_20170	COG2814	Major facilitator Superfamily
ES969_20175	COG4895	conserved protein (DUF2196)
ES969_20180	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ES969_20185	COG0346	lactoylglutathione lyase activity
ES969_20195	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES969_20200	COG1404	Belongs to the peptidase S8 family
ES969_20205	COG1263	PTS System
ES969_20205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES969_20210	COG3711	transcriptional antiterminator
ES969_20215	COG1442	glycosyl transferase family 8
ES969_20220	COG5522	Integral membrane protein (intg_mem_TP0381)
ES969_20225	COG1846	Transcriptional regulator
ES969_20230	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ES969_20235	COG2234	aminopeptidase activity
ES969_20240	COG2357	RelA SpoT domain protein
ES969_20250	COG1575	Belongs to the MenA family. Type 1 subfamily
ES969_20270	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES969_20275	COG1696	Membrane protein involved in D-alanine export
ES969_20280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES969_20285	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ES969_20295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES969_20300	COG1486	melibiose metabolic process
ES969_20305	COG1447	Phosphotransferase system cellobiose-specific component IIA
ES969_20310	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES969_20315	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES969_20320	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES969_20320	COG3711	transcriptional antiterminator
ES969_20330	COG2094	Belongs to the DNA glycosylase MPG family
ES969_20335	COG0753	catalase activity
ES969_20345	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES969_20350	COG1131	(ABC) transporter
ES969_20370	COG1595	DNA-templated transcription, initiation
ES969_20375	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ES969_20380	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ES969_20385	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ES969_20390	COG4988	ABC transporter
ES969_20395	COG1294	oxidase, subunit
ES969_20400	COG1271	oxidase subunit
ES969_20405	COG3493	citrate carrier protein
ES969_20410	COG0501	Belongs to the peptidase M48B family
ES969_20420	COG0726	polysaccharide deacetylase
ES969_20425	COG3842	ATPase activity
ES969_20430	COG2508	Transcriptional regulator
ES969_20435	COG1012	belongs to the aldehyde dehydrogenase family
ES969_20440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES969_20445	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ES969_20455	COG4585	Histidine kinase
ES969_20460	COG2197	response regulator
ES969_20465	COG2195	Cleaves the N-terminal amino acid of tripeptides
ES969_20475	COG4894	glucomannan catabolic process
ES969_20480	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ES969_20485	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ES969_20490	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_20495	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ES969_20505	COG2610	gluconate transmembrane transporter activity
ES969_20510	COG0500	methyltransferase
ES969_20515	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES969_20530	COG0753	catalase activity
ES969_20530	COG0693	protein deglycase activity
ES969_20535	COG2851	Citrate transporter
ES969_20540	COG2273	Hydrolase Family 16
ES969_20545	COG3711	transcriptional antiterminator
ES969_20560	COG2270	Major facilitator Superfamily
ES969_20565	COG0513	Belongs to the DEAD box helicase family
ES969_20570	COG2755	lipolytic protein G-D-S-L family
ES969_20570	COG3401	FG-GAP repeat protein
ES969_20700	COG0589	response to stress
ES969_20720	COG5444	nuclease activity
ES969_20735	COG3507	Belongs to the glycosyl hydrolase 43 family
ES969_20750	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ES969_20755	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES969_20760	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ES969_20765	COG2390	Transcriptional regulator
ES969_20775	COG3192	ethanolamine utilization protein
ES969_20780	COG2079	MmgE PrpD family protein
ES969_20790	COG1126	abc transporter atp-binding protein
ES969_20795	COG0765	amino acid transport
ES969_20800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES969_20815	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
ES969_20820	COG0561	phosphatase activity
ES969_20850	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES969_20855	COG5294	Protein conserved in bacteria
ES969_20860	COG0577	efflux transmembrane transporter activity
ES969_20865	COG1136	(ABC) transporter
ES969_20870	COG2205	protein histidine kinase activity
ES969_20880	COG0191	fructose-bisphosphate aldolase activity
ES969_20885	COG1082	Xylose isomerase domain protein TIM barrel
ES969_20890	COG1082	Xylose isomerase domain protein TIM barrel
ES969_20895	COG0673	inositol 2-dehydrogenase activity
ES969_20900	COG2814	Major facilitator Superfamily
ES969_20905	COG1082	Xylose isomerase domain protein TIM barrel
ES969_20910	COG3962	Belongs to the TPP enzyme family
ES969_20915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES969_20930	COG1349	DNA-binding transcription factor activity
ES969_20935	COG0667	Aldo Keto reductase
ES969_20960	COG2814	Major facilitator Superfamily
ES969_20965	COG0326	Molecular chaperone. Has ATPase activity
ES969_20980	COG1309	transcriptional regulator
ES969_20985	COG1012	belongs to the aldehyde dehydrogenase family
ES969_20990	COG1714	RDD family
ES969_21000	COG1714	RDD family
ES969_21005	COG2311	Membrane
ES969_21010	COG1917	Cupin 2, conserved barrel domain protein
ES969_21015	COG1309	transcriptional regulator
ES969_21020	COG1028	Short-chain dehydrogenase reductase Sdr
ES969_21025	COG1846	Transcriptional regulator
ES969_21030	COG1380	Effector of murein hydrolase LrgA
ES969_21035	COG1346	cytolysis
ES969_21040	COG5039	Polysaccharide pyruvyl transferase
ES969_21045	COG1929	Belongs to the glycerate kinase type-1 family
ES969_21050	COG1802	Transcriptional regulator
ES969_21055	COG1070	Carbohydrate kinase
ES969_21060	COG2610	gluconate transmembrane transporter activity
ES969_21065	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ES969_21070	COG0450	alkyl hydroperoxide reductase
ES969_21075	COG3634	alkyl hydroperoxide reductase activity
ES969_21080	COG2723	6-phospho-beta-galactosidase activity
ES969_21095	COG2188	Transcriptional regulator
ES969_21105	COG1131	(ABC) transporter
ES969_21110	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
ES969_21115	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ES969_21140	COG1401	restriction endodeoxyribonuclease activity
ES969_21170	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
ES969_21175	COG0456	acetyltransferase
ES969_21180	COG0457	Tetratricopeptide repeat
ES969_21190	COG0010	Belongs to the arginase family
ES969_21195	COG0833	amino acid
ES969_21200	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ES969_21220	COG5658	integral membrane protein
ES969_21225	COG0640	Transcriptional regulator
ES969_21230	COG3829	transcription factor binding
ES969_21245	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES969_21250	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ES969_21255	COG4853	Protein conserved in bacteria
ES969_21260	COG4863	YycH protein
ES969_21265	COG5002	protein histidine kinase activity
ES969_21270	COG0745	RESPONSE REGULATOR receiver
ES969_21300	COG0346	lactoylglutathione lyase activity
ES969_21305	COG0305	Participates in initiation and elongation during chromosome replication
ES969_21320	COG3093	addiction module antidote protein HigA
ES969_21325	COG2807	transmembrane transport
ES969_21330	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ES969_21335	COG0359	binds to the 23S rRNA
ES969_21340	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ES969_21345	COG4241	membrane
ES969_21360	COG1733	regulation of RNA biosynthetic process
ES969_21365	COG1227	inorganic diphosphatase activity
ES969_21380	COG2271	Major facilitator Superfamily
ES969_21385	COG0789	Transcriptional regulator
ES969_21385	COG4978	Transcriptional regulator
ES969_21395	COG4319	ketosteroid isomerase
ES969_21400	COG1357	PFAM Pentapeptide repeats (8 copies)
ES969_21415	COG1846	Transcriptional regulator
ES969_21420	COG2153	protein acetylation
ES969_21425	COG2364	Membrane
ES969_21430	COG0456	acetyltransferase
ES969_21440	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ES969_21450	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ES969_21455	COG1331	Highly conserved protein containing a thioredoxin domain
ES969_21460	COG1266	CAAX protease self-immunity
ES969_21465	COG0477	Major facilitator Superfamily
ES969_21465	COG2814	Major facilitator Superfamily
ES969_21470	COG0346	lactoylglutathione lyase activity
ES969_21475	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ES969_21480	COG0542	response to heat
ES969_21495	COG0708	Exodeoxyribonuclease III
ES969_21500	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ES969_21505	COG0629	single-stranded DNA binding
ES969_21510	COG0360	Binds together with S18 to 16S ribosomal RNA
ES969_21515	COG0012	GTP binding
ES969_21520	COG0243	molybdopterin cofactor binding
ES969_21525	COG4481	Protein conserved in bacteria
ES969_21530	COG3949	Membrane
ES969_21540	COG1475	DNA binding
ES969_21545	COG1192	Involved in chromosome partitioning
ES969_21555	COG1475	DNA binding
ES969_21560	COG0357	Ribosomal RNA small subunit methyltransferase G
ES969_21565	COG0445	tRNA wobble uridine modification
ES969_21570	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ES969_21575	COG1847	R3H domain protein
ES969_21580	COG0706	membrane insertase activity
ES969_21585	COG0594	ribonuclease P activity
ES969_21590	COG0230	Belongs to the bacterial ribosomal protein bL34 family