locus-tag class description ES963_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) ES963_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) ES963_00015 ENOG410848D S4 domain protein YaaA ES963_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ES963_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ES963_00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) ES963_00080 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) ES963_00085 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) ES963_00090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) ES963_00100 ENOG4105ZMH deoxynucleoside kinase ES963_00110 ENOG4105VRS hydrolase family 18 ES963_00115 ENOG4105GTG Isochorismatase ES963_00120 ENOG4108Z6B deaminase ES963_00130 ENOG4105C6E dna polymerase iii ES963_00135 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) ES963_00140 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) ES963_00150 ENOG41067KS pro-sigma K processing ES963_00190 ENOG4105CDW Resistance protein ES963_00195 ENOG4105CXN decarboxylase ES963_00200 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) ES963_00205 ENOG4105X0R protein from nitrogen regulatory protein P-II ES963_00210 ENOG4105XVJ Protein of unknown function (DUF327) ES963_00215 ENOG4105FA2 dna polymerase iii ES963_00220 ENOG4105MA4 psp1 domain protein ES963_00225 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) ES963_00230 ENOG41060K3 Methyltransferase ES963_00235 ENOG4105VC4 domain protein ES963_00240 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) ES963_00245 ENOG4105KRN Transcriptional regulator, abrb family ES963_00250 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) ES963_00255 ENOG4105F8V Hydrolase, tatD family ES963_00260 ENOG41069ER domain protein ES963_00270 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) ES963_00275 ENOG4105XFA sporulation peptidase YabG ES963_00280 ENOG4105W42 Veg protein ES963_00285 ENOG4105XEW small acid-soluble spore protein ES963_00290 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) ES963_00295 ENOG4105DFT pur operon repressor ES963_00300 ENOG4105KME endoribonuclease L-psp ES963_00305 ENOG4105K4W Could be involved in septation (By similarity) ES963_00310 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) ES963_00315 ENOG4105C5T Phosphoribosyl pyrophosphate synthase ES963_00320 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) ES963_00325 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) ES963_00335 ENOG4108JA2 transcriptioN-repair coupling factor ES963_00340 ENOG4108M14 stage v sporulation protein t ES963_00350 ENOG4108IY2 MazG family ES963_00355 ENOG41082I2 s4 domain protein ES963_00360 ENOG4105VYY sporulation protein yabp ES963_00375 ENOG41060GV RNA binding s1 domain protein ES963_00405 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) ES963_00410 ENOG4108UGV hypoxanthine phosphoribosyltransferase ES963_00415 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ES963_00425 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) ES963_00430 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase ES963_00435 ENOG4105C6T cysteine synthase ES963_00440 ENOG4105CRQ synthase (Component I) ES963_00445 ENOG4105DDQ anthranilate synthase ES963_00450 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 ES963_00455 ENOG4105EEI dihydropteroate synthase ES963_00460 ENOG4105KRF dihydroneopterin aldolase ES963_00465 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ES963_00475 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) ES963_00480 ENOG4105CRK lysyL-tRNA synthetase ES963_00565 ENOG4108Z0C Uvrb UvrC protein ES963_00570 ENOG41066A3 ATP guanido phosphotransferase ES963_00580 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) ES963_00585 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) ES963_00590 ENOG4105CTP PilT protein domain protein ES963_00595 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) ES963_00600 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) ES963_00605 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) ES963_00615 ENOG4105D7W serine acetyltransferase ES963_00620 ENOG4105C8N cysteinyl-tRNA synthetase ES963_00625 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) ES963_00630 ENOG4105C2N RNA methyltransferase TrmH family group 3 ES963_00635 ENOG4105M0M Tetracycline resistance protein ES963_00655 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) ES963_00660 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) ES963_00670 ENOG4108VZM 50s ribosomal protein L10 ES963_00675 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) ES963_00680 ENOG4107Y49 methyltransferase ES963_00685 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ES963_00690 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ES963_00695 ENOG4105XPM ribosomal protein ES963_00700 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) ES963_00705 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) ES963_00710 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) ES963_00715 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) ES963_00720 ENOG4107SKW Inherit from COG: Alpha beta hydrolase ES963_00725 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) ES963_00730 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) ES963_00735 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) ES963_00740 ENOG41080UE One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) ES963_00745 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity ES963_00750 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) ES963_00755 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) ES963_00760 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) ES963_00765 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) ES963_00770 ENOG41082SA 50s ribosomal protein l29 ES963_00775 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal ES963_00780 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) ES963_00790 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits ES963_00800 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) ES963_00805 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) ES963_00810 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) ES963_00815 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) ES963_00820 ENOG4105VPB 50S ribosomal protein L30 ES963_00825 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) ES963_00830 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) ES963_00840 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) ES963_00850 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) ES963_00860 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits ES963_00865 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) ES963_00870 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ES963_00875 ENOG4108ZT0 50S ribosomal protein l17 ES963_00880 ENOG4108JJB ABC transporter ES963_00885 ENOG4108JJB ABC transporter ES963_00890 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) ES963_00895 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) ES963_00900 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) ES963_00905 ENOG4108UJD 30S ribosomal protein S9 ES963_00910 ENOG4108I0C methyltransferase ES963_00925 ENOG4105D1F ATP-binding protein ES963_00940 ENOG4108NMV polysaccharide deacetylase ES963_01025 ENOG4105CHH sulfate transporter ES963_01035 ENOG4108SA1 esterase ES963_01055 ENOG410874W AraC family transcriptional regulator ES963_01060 ENOG4105EHZ conserved protein UCP016719 ES963_01065 ENOG4105D17 glycoside hydrolase, family 3 domain protein ES963_01085 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate ES963_01095 ENOG4105EWC Purine nucleoside phosphorylase ES963_01125 ENOG4105EMN RNA polymerase sigma factor ES963_01135 ENOG4105C8B TIGR00159 family ES963_01140 ENOG4107U5W ybbr family ES963_01145 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) ES963_01150 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) ES963_01160 ENOG4105D03 DNA-3-methyladenine glycosylase II ES963_01170 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ES963_01175 ENOG4108TWJ NADH dehydrogenase subunit 5 ES963_01195 ENOG4105GPN Uncharacterized conserved protein (DUF2294) ES963_01200 ENOG4105WAB arsR family transcriptional regulator ES963_01210 ENOG4108RWP Major Facilitator Superfamily protein ES963_01245 ENOG4105G0J serine threonine protein kinase ES963_01255 ENOG4106K80 ES963_01265 ENOG4106DDH Sporulation-specific SASP protein ES963_01275 ENOG4108HWY Beta-lactamase ES963_01280 ENOG4107E6A Cytochrome p-450 ES963_01290 ENOG4107QTZ amino acid ES963_01295 ENOG4107VXM glycerophosphoryl diester phosphodiesterase ES963_01300 ENOG4105CXY transporter ES963_01315 ENOG410645S MarR family Transcriptional regulator ES963_01320 ENOG4105DCM major facilitator superfamily ES963_01325 ENOG410631K Membrane ES963_01330 ENOG4106AXJ AraC family transcriptional regulator ES963_01350 ENOG4105GIG ES963_01355 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR ES963_01360 ENOG4108TCS Glutamyl endopeptidase ES963_01370 ENOG4108WC5 Alpha Beta Hydrolase Fold protein ES963_01375 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase ES963_01380 ENOG4107ZTW SNARE associated Golgi ES963_01405 ENOG4105C72 UPF0176 protein ES963_01415 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane ES963_01420 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) ES963_01425 ENOG4108X79 transcriptional regulator ES963_01435 ENOG4105CM2 brancheD-chain amino acid aminotransferase ES963_01440 ENOG4108IQI permease ES963_01445 ENOG4108J5H Homocysteine s-methyltransferase ES963_01460 ENOG4105CSV Glutaminase ES963_01480 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase ES963_01485 ENOG4105C26 Dehydrogenase ES963_01490 ENOG4105DJB Major Facilitator Superfamily ES963_01495 ENOG4105EQX glucarate dehydratase ES963_01500 ENOG41073TP transcriptional regulator ES963_01505 ENOG4105CTX dehydratase ES963_01525 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ES963_01560 ENOG4105MUA Resistance protein ES963_01570 ENOG4105DGI Alkaline phosphatase ES963_01575 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) ES963_01580 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) ES963_01585 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) ES963_01590 ENOG4107EPV Aminotransferase class V ES963_01595 ENOG4105C0R drug resistance transporter emrb qaca subfamily ES963_01600 ENOG4105J7D transcriptional regulator ES963_01605 ENOG4107RB3 L-asparaginase ES963_01620 ENOG41060AI SEC-C motif ES963_01630 ENOG4107Y7X LytTR ES963_01635 ENOG4108IUW ABC transporter ES963_01640 ENOG4108SDH ABC, transporter ES963_01645 ENOG4107SET aldo keto reductase ES963_01680 ENOG4105H9W Short-chain dehydrogenase reductase Sdr ES963_01690 ENOG4105DSE periplasmic solute binding protein ES963_01695 ENOG4105DIK (ABC) transporter ES963_01705 ENOG4105DEN Luciferase family ES963_01710 ENOG4108N0M stress protein ES963_01715 ENOG4106FN3 tellurium resistance protein ES963_01720 ENOG4106FN3 tellurium resistance protein ES963_01725 ENOG4107TS3 membrane protein, TerC ES963_01730 ENOG4108TTB tellurium resistance protein ES963_01740 ENOG41079KZ Major Facilitator Superfamily ES963_01750 ENOG4107XZQ multidrug resistance protein ES963_01755 ENOG4108A65 Transcriptional regulator ES963_01760 ENOG4108IJ7 Glycine betaine ES963_01765 ENOG4107SQ8 Glycine betaine ES963_01795 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) ES963_01830 ENOG4105EIG urea carboxylase-associated protein 1 ES963_01835 ENOG4107RA1 nh(3)-dependent nad( ) synthetase ES963_01840 ENOG4105I1F Resistance protein ES963_01845 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) ES963_01850 ENOG41089UC methyltransferase, type 11 ES963_01855 ENOG4105C5Q Transcriptional regulator ES963_01860 ENOG4105I82 acetyl xylan esterase ES963_01865 ENOG410756H nucleotidyltransferase ES963_01875 ENOG4105C26 Dehydrogenase ES963_01880 ENOG4105CK7 Sodium proline symporter ES963_01885 ENOG4107YHD transcriptional regulator ES963_01895 ENOG4108PJD permease ES963_01900 ENOG4105U6C Alpha beta hydrolase fold protein ES963_01910 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) ES963_01915 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit ES963_01920 ENOG4108IFG nitrite reductase, (NAD(P)H) ES963_01925 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ES963_01945 ENOG4105S7A ErfK ybiS ycfS ynhG family protein ES963_01955 ENOG4105CKI cobalamin synthesis protein ES963_01960 ENOG4105E5Q amino acid AbC transporter ES963_01965 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein ES963_01975 ENOG4105HHM rdd domain containing protein ES963_01985 ENOG4105K56 Transcriptional regulator ES963_01995 ENOG4108VEN abc transporter atp-binding protein ES963_02000 ENOG4105CS2 ec 3.2.1.21 ES963_02015 ENOG4105C8Q Methyl-accepting chemotaxis ES963_02020 ENOG41080HJ 6-phospho 3-hexuloisomerase ES963_02025 ENOG4108VA3 3-hexulose-6-phosphate synthase ES963_02030 ENOG4105KVH Transcriptional regulator ES963_02035 ENOG4105CEY Amp-dependent synthetase and ligase ES963_02065 ENOG4105SX7 Transporter ES963_02075 ENOG4105W8Z 4'-phosphopantetheinyl transferase ES963_02085 ENOG4105CDA abc transporter atp-binding protein ES963_02090 ENOG4105DRP amino acid AbC transporter ES963_02100 ENOG4106P55 Transcriptional regulator ES963_02105 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase ES963_02110 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) ES963_02115 ENOG41069ZX ES963_02120 ENOG41069ZX ES963_02130 ENOG4105DUX Transporter ES963_02145 ENOG4105E1K spore germination protein ES963_02165 ENOG4107WD8 ABC transporter, permease ES963_02170 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ES963_02175 ENOG4105BZU Histidine kinase ES963_02200 ENOG4105CFH Aspartokinase ES963_02205 ENOG4105DHS permease protein ES963_02210 ENOG4105CM4 permease protein ES963_02215 ENOG4108IPW abc transporter atp-binding protein ES963_02235 ENOG4105R8C Transcriptional regulator ES963_02240 ENOG4108DBC nitroreductase ES963_02245 ENOG41067V3 Antibiotic biosynthesis monooxygenase ES963_02250 ENOG4105YVS arsR family transcriptional regulator ES963_02260 ENOG4108JPW Aminotransferase ES963_02265 ENOG4105C26 Dehydrogenase ES963_02275 ENOG4105H9W Short-chain dehydrogenase reductase Sdr ES963_02280 ENOG4105KTB nuclear export factor GLE1 ES963_02285 ENOG4108T5E Copper resistance protein ES963_02290 ENOG4108ZYE Transcriptional regulator ES963_02315 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) ES963_02320 ENOG4108ZX0 Signal peptidase I ES963_02345 ENOG4105E7W lamb ycsf family protein ES963_02350 ENOG4105C5A transporter ES963_02355 ENOG4105CFM UPF0317 protein ES963_02360 ENOG4105P4J Allophanate hydrolase, subunit 1 ES963_02370 ENOG4107258 Transcriptional regulator ES963_02375 ENOG4105XJB lipolytic protein G-D-S-L family ES963_02385 ENOG41061CK Antibiotic biosynthesis monooxygenase ES963_02390 ENOG4107RVG penicillin-binding protein ES963_02395 ENOG4107QM2 Aldo Keto reductase ES963_02400 ENOG4105ETD TRANSCRIPTIONal ES963_02410 ENOG4105HMZ Methyltransferase ES963_02415 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ES963_02430 ENOG410606W general stress protein ES963_02440 ENOG4105VCH membrane ES963_02450 ENOG4105C9U ATP-dependent DNA helicase RecQ ES963_02465 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) ES963_02470 ENOG4107R8N Glycosyl transferase, family 2 ES963_02480 ENOG4105C0X amino acid ES963_02520 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) ES963_02530 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) ES963_02535 ENOG4105EU9 ES963_02540 ENOG4105QVS general stress protein ES963_02545 ENOG41082W1 Cupin 2, conserved barrel domain protein ES963_02560 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit ES963_02565 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism ES963_02570 ENOG4108MRH transcriptional regulatory protein ES963_02575 ENOG4107QJT sodium dicarboxylate symporter ES963_02580 ENOG4106F5Q Membrane ES963_02585 ENOG4105CJ1 ABC, transporter ES963_02600 ENOG4105FDT acyl-CoA dehydrogenase ES963_02620 ENOG4105SZ6 Thioredoxin ES963_02625 ENOG4105CPF Cell wall formation (By similarity) ES963_02630 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) ES963_02640 ENOG4105C1J atp-dependent rna helicase ES963_02645 ENOG410905X membrane-flanked domain protein ES963_02650 ENOG4105CKV Membrane ES963_02660 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) ES963_02665 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein ES963_02670 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ES963_02680 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) ES963_02685 ENOG4107MMM Anti-sigma-factor antagonist ES963_02690 ENOG4105FUA antagonist ES963_02695 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase ES963_02700 ENOG4107SGM protein serine threonine phosphatase ES963_02705 ENOG4105WN5 stage II sporulation protein ES963_02710 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) ES963_02720 ENOG41064BQ Phosphatase ES963_02785 ENOG4107V2S Transcriptional regulator ES963_02800 ENOG4106BHF ES963_02810 ENOG4105VZ8 Transcriptional regulator ES963_02835 ENOG4108V4B ThiJ pfpI ES963_02840 ENOG4105VEQ Cold shock protein ES963_02845 ENOG4108VJ1 Transcriptional regulator (CarD family ES963_02860 ENOG4108MCI Transcriptional regulator, ARAC family ES963_02865 ENOG4108UZ3 Transporter ES963_02870 ENOG41086D8 Transcriptional regulator ES963_02875 ENOG4107U9B transcriptional regulator ES963_02890 ENOG4105CZ9 Domain of unknown function (DU1801) ES963_02895 ENOG4105GIG ES963_02905 ENOG4105KRI phosphocarrier protein (HPr ES963_02910 ENOG4105ST3 Transcriptional regulator ES963_02915 ENOG4105T38 integral membrane protein ES963_02920 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ES963_02925 ENOG4108ZMQ domain protein ES963_02930 ENOG4105MJ9 esterase ES963_02935 ENOG4107Z6X Transcriptional regulator ES963_02945 ENOG4105KVH Transcriptional regulator ES963_02950 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein ES963_02955 ENOG4105EQ0 Major Facilitator superfamily ES963_02960 ENOG4108JGH Tetr family transcriptional regulator ES963_02965 ENOG41082YX Transcriptional regulator, arsr family ES963_02970 ENOG4107R5R arsenical pump membrane protein ES963_02980 ENOG4105Z7P Acetyltransferase (GNAT) family ES963_02985 ENOG4107Y9U Membrane ES963_02995 ENOG4105DY8 decarboxylase ES963_03000 ENOG4108SQ9 flavin reductase domain protein, FMN-binding ES963_03005 ENOG4108ZHR arsR family transcriptional regulator ES963_03010 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) ES963_03025 ENOG4105ENE Histidine kinase ES963_03030 ENOG4108VB1 regulatoR ES963_03035 ENOG4105EYF MMPL domain protein ES963_03040 ENOG4108UQV Membrane ES963_03045 ENOG4108Z5V transcriptional regulator, merr family ES963_03050 ENOG41076HS cation diffusion facilitator family transporter ES963_03055 ENOG4108TVJ Nitroreductase ES963_03060 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase ES963_03065 ENOG4108VGI doxx family ES963_03070 ENOG4105XXY Thioredoxin ES963_03085 ENOG410900G Protein of unknown function (DUF421) ES963_03090 ENOG4108QY0 Membrane ES963_03110 ENOG4105PF9 Transcriptional regulator ES963_03120 ENOG4105WQG acetyltransferase ES963_03130 ENOG4105C85 amino acid ES963_03140 ENOG41062A4 Transcriptional regulator ES963_03145 ENOG4105EYF MMPL domain protein ES963_03150 ENOG4108TVJ Nitroreductase ES963_03155 ENOG4105FS7 Transcriptional regulator ES963_03160 ENOG4105C2C drug resistance transporter, Bcr CflA ES963_03170 ENOG4105DRR Transcriptional regulator, GntR family ES963_03175 ENOG4105VRS hydrolase family 18 ES963_03190 ENOG4105G6Z alkaline phosphatase ES963_03195 ENOG4108ZMX Domain of unknown function (DU1801) ES963_03205 ENOG4108YM7 Gcn5-related n-acetyltransferase ES963_03210 ENOG4107TVP HD domain protein ES963_03215 ENOG41090UD (LipO)protein ES963_03220 ENOG4105F27 Major Facilitator ES963_03225 ENOG4105VZJ PTS System ES963_03230 ENOG4105VCP PTS System ES963_03235 ENOG4105CK1 PTS System ES963_03240 ENOG4105CS2 ec 3.2.1.21 ES963_03245 ENOG4108TZY GntR Family Transcriptional Regulator ES963_03250 ENOG4105EVU fructokinase ES963_03255 ENOG4105DG6 mannose-6-phosphate isomerase ES963_03260 ENOG4105D3P Mannan endo-1,4-beta-mannosidase ES963_03305 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) ES963_03310 ENOG4105K8N protein family UPF0079, ATPase ES963_03315 ENOG41072GX Peptidase M22 Glycoprotease ES963_03320 ENOG410801F ribosomal-protein-alanine acetyltransferase ES963_03325 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ES963_03330 ENOG4105C5H ABC transporter ES963_03335 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) ES963_03340 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) ES963_03345 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) ES963_03350 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) ES963_03365 ENOG4108TYN CAAX amino terminal protease family protein ES963_03370 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) ES963_03375 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) ES963_03390 ENOG4105PGZ NB-ARC domain ES963_03395 ENOG4105CPQ Dehydrogenase ES963_03400 ENOG4105CT4 transporter ES963_03415 ENOG4105DQX Zinc finger domain ES963_03420 ENOG4108WV1 Pfam:DUF477 ES963_03430 ENOG4108ZMR Ion transport 2 domain-containing protein ES963_03435 ENOG4107QNK )-transporter ES963_03465 ENOG4107YUH hydrolase ES963_03475 ENOG4107STQ Multicopper oxidase ES963_03480 ENOG4105C85 amino acid ES963_03495 ENOG4105C7R Atpase associated with various cellular activities aaa_3 ES963_03525 ENOG4105C7N Xanthine uracil vitamin C permease ES963_03550 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) ES963_03555 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit ES963_03560 ENOG4105C83 adenylosuccinate lyase ES963_03565 ENOG4105C8V SAICAR synthetase ES963_03570 ENOG4105VR9 phosphoribosylformylglycinamidine synthase ES963_03575 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I ES963_03580 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii ES963_03590 ENOG4105CXB phosphoribosylaminoimidazole synthetase ES963_03595 ENOG4108V3E phosphoribosylglycinamide formyltransferase ES963_03600 ENOG4105DC1 bifunctional purine biosynthesis protein purh ES963_03605 ENOG4105C12 Phosphoribosylglycinamide synthetase ES963_03615 ENOG4105DVH amino acid ES963_03630 ENOG4108R5T secreted protein ES963_03635 ENOG4105KGF protein, YerC YecD ES963_03645 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) ES963_03650 ENOG4105C4R Atp-dependent dna helicase ES963_03655 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) ES963_03665 ENOG4105CRN Aminoglycoside phosphotransferase ES963_03670 ENOG4105KT7 mgtC SapB transporter ES963_03675 ENOG4105CK7 Sodium proline symporter ES963_03680 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) ES963_03685 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) ES963_03690 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) ES963_03695 ENOG4108IG5 Transcriptional regulator ES963_03705 ENOG4105CBD Diacylglycerol kinase ES963_03710 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) ES963_03785 ENOG4108HFV ES963_03805 ENOG4105CDY transcriptional regulatory protein ES963_03815 ENOG4105M4P Tetr family transcriptional regulator ES963_03820 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein ES963_03825 ENOG4107S9F NmrA family ES963_03840 ENOG4105WEF catalase ES963_03845 ENOG4105M18 -acetyltransferase ES963_03860 ENOG4105C2F Histidine kinase ES963_03865 ENOG4105EQD regulatoR ES963_03870 ENOG410769Z extracellular solute-binding protein family 1 ES963_03875 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component ES963_03880 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component ES963_03885 ENOG4105F5H Glycosyl Hydrolase Family 88 ES963_03890 ENOG41075H3 AraC family transcriptional regulator ES963_03895 ENOG4107TDE lipolytic protein G-D-S-L family ES963_03910 ENOG4105CX8 fg-gap repeat protein ES963_03915 ENOG4105CX8 fg-gap repeat protein ES963_03920 ENOG4107TDE lipolytic protein G-D-S-L family ES963_03930 ENOG4105EKC ES963_03945 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component ES963_03955 ENOG4105H67 Protein of unknown function (DUF421) ES963_03960 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) ES963_03965 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily ES963_03985 ENOG4106I4J membrane ES963_03990 ENOG4108PCN EamA-like transporter family ES963_03995 ENOG41082F9 transcriptional regulator ES963_04000 ENOG41061H0 Monooxygenase ES963_04005 ENOG4108R1P ES963_04010 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) ES963_04015 ENOG4105E0M Sulfatase ES963_04020 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase ES963_04035 ENOG4107R51 Glycosyl transferase, family 2 ES963_04040 ENOG41090R9 glycosyltransferase ES963_04045 ENOG4105EU0 Major facilitator Superfamily ES963_04055 ENOG4105CUB amino acid ES963_04060 ENOG4105C26 Dehydrogenase ES963_04065 ENOG4105FKZ Methyl-accepting chemotaxis ES963_04070 ENOG4105C5H ABC transporter ES963_04085 ENOG4105DXB Major Facilitator superfamily ES963_04100 ENOG4105C5H ABC transporter ES963_04105 ENOG4105FDU atp-dependent rna helicase ES963_04115 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein ES963_04120 ENOG4105E0A ABC, transporter ES963_04125 ENOG4108U1V ABC transporter, permease ES963_04130 ENOG4105DQ5 transport system permease protein ES963_04135 ENOG4108HUF Transporter ES963_04150 ENOG4108J20 pectate lyase ES963_04155 ENOG4107QPK )-transporter ES963_04165 ENOG4108MRH transcriptional regulatory protein ES963_04190 ENOG410855V Acylphosphatase ES963_04195 ENOG4108RPX mosc domain containing protein ES963_04215 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) ES963_04245 ENOG4105E1K spore germination protein ES963_04250 ENOG4105E1K spore germination protein ES963_04255 ENOG4105C5Y PTS System ES963_04260 ENOG4105CG3 alpha amylase, catalytic region ES963_04265 ENOG4107414 GntR family transcriptional regulator ES963_04270 ENOG4108RCM Nitroreductase ES963_04275 ENOG4105CGH 5'-nucleotidase ES963_04280 ENOG4107RKG DJ-1/PfpI family ES963_04295 ENOG4105KJF protein tyrosine phosphatase ES963_04310 ENOG4108ISG Major Facilitator ES963_04315 ENOG4105UPD Calcium Proton ES963_04325 ENOG4105D8X mechanosensitive ion channel ES963_04345 ENOG4106KE4 Dehydrogenase ES963_04350 ENOG4105D7N magnesium and cobalt transport protein CorA ES963_04360 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) ES963_04385 ENOG4107RUY (E1 component), alpha subunit ES963_04395 ENOG4107QKR Dehydrogenase ES963_04405 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family ES963_04410 ENOG41069DP small acid-soluble spore protein ES963_04415 ENOG4105KK4 UPF0060 membrane protein ES963_04445 ENOG4105F8D glycoside hydrolase family 4 ES963_04450 ENOG4108Q3X Transcriptional regulator ES963_04455 ENOG4105CI1 PTS System ES963_04465 ENOG4105BZ1 (ABC) transporter ES963_04470 ENOG4105BZ1 (ABC) transporter ES963_04480 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase ES963_04485 ENOG4105BZU Histidine kinase ES963_04490 ENOG4105WH1 Two component transcriptional regulator luxr family ES963_04500 ENOG4105CJ1 ABC, transporter ES963_04505 ENOG41090VJ ABC-2 type transporter ES963_04510 ENOG4108KYE ABC-2 type transporter ES963_04515 ENOG4105U3E Transcriptional regulator ES963_04520 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold ES963_04525 ENOG4105H93 Acyltransferase family ES963_04530 ENOG4105YA8 Transcriptional regulator ES963_04535 ENOG4107Y80 Major Facilitator superfamily ES963_04540 ENOG4108YYS metal-dependent hydrolase (By similarity) ES963_04545 ENOG4105C0R drug resistance transporter emrb qaca subfamily ES963_04550 ENOG410834F Transcriptional regulator ES963_04560 ENOG4108MES Periplasmic binding protein ES963_04565 ENOG4105DQ5 transport system permease protein ES963_04570 ENOG4108IHU transport system permease protein ES963_04575 ENOG4105JAB phenazine biosynthesis protein, phzf family ES963_04580 ENOG4107Y03 Nitroreductase ES963_04595 ENOG4105ECP epimerase ES963_04610 ENOG4105F27 Major Facilitator ES963_04630 ENOG4106AKJ ES963_04635 ENOG4105D74 hydrolase ES963_04640 ENOG4105CKK Glycosyl transferase, family 2 ES963_04645 ENOG4105EJV Membrane ES963_04650 ENOG41067AE Membrane-bound metal-dependent hydrolase ES963_04655 ENOG4105CEN a g-specific adenine glycosylase ES963_04660 ENOG4106BXE ES963_04665 ENOG4105CAN Short-chain dehydrogenase reductase Sdr ES963_04680 ENOG4105EVI UPF0374 protein ES963_04685 ENOG4105BZ1 (ABC) transporter ES963_04690 ENOG4107NBY Membrane ES963_04700 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ES963_04705 ENOG4105G5W regulator Fur family ES963_04815 ENOG4108N23 SpoOM-related protein ES963_04830 ENOG4105EC3 peptidase S51, dipeptidase E ES963_04835 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) ES963_04850 ENOG4105E2Y ABC, transporter ES963_04855 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein ES963_04860 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component ES963_04865 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) ES963_04875 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) ES963_04880 ENOG4107D63 ES963_04885 ENOG4105VZ8 Transcriptional regulator ES963_04900 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) ES963_04910 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) ES963_04930 ENOG4105CYN Serine protein kinase ES963_04935 ENOG4106AKX UPF0229 protein ES963_04940 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes ES963_04945 ENOG4105CW7 secretion protein, HlyD family ES963_04950 ENOG4105C0R drug resistance transporter emrb qaca subfamily ES963_04955 ENOG4105CS1 NAD(P)H quinone oxidoreductase ES963_04975 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family ES963_04980 ENOG4105CZV ABC transporter ES963_04985 ENOG4105CJ1 ABC, transporter ES963_04990 ENOG4108TU7 Inherit from COG: (ABC) transporter ES963_04995 ENOG4105VEQ Cold shock protein ES963_05045 ENOG4105EYG tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site (By similarity) ES963_05050 ENOG4106128 DNA-binding helix-turn-helix protein ES963_05095 ENOG4105P1M Domain of unknown function (DUF1874) ES963_05105 ENOG4105K4H Nlp p60 protein ES963_05170 ENOG4108YBP pseudouridine synthase ES963_05180 ENOG41080XP Cbs domain ES963_05185 ENOG4107YBY Hydrolase ES963_05190 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase ES963_05195 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ES963_05200 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator ES963_05210 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) ES963_05215 ENOG4105C6V Glycerol-3-phosphate dehydrogenase ES963_05225 ENOG4105BZU Histidine kinase ES963_05230 ENOG4105WH1 Two component transcriptional regulator luxr family ES963_05265 ENOG4105ED1 spovr family ES963_05270 ENOG4105G6Z alkaline phosphatase ES963_05285 ENOG4105BZN citrate synthase ES963_05290 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ES963_05295 ENOG4105CUB amino acid ES963_05300 ENOG4105C8J )-transporter ES963_05305 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ES963_05320 ENOG4105J37 ES963_05325 ENOG4108AEY RNA polymerase sigma factor ES963_05330 ENOG4108FN7 Aldo keto reductase ES963_05335 ENOG4105F6E Acyl-transferase ES963_05340 ENOG4105C37 (CBS) domain ES963_05350 ENOG4105CHM Aminotransferase ES963_05355 ENOG4105C37 (CBS) domain ES963_05365 ENOG4105WMR Protein CrcB homolog ES963_05370 ENOG4108QXE glycerophosphoryl diester phosphodiesterase ES963_05380 ENOG4105D64 Mechanosensitive ion channel ES963_05385 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) ES963_05390 ENOG4107VMI polysaccharide deacetylase ES963_05395 ENOG4105F0I Aminotransferase ES963_05415 ENOG4105BZ1 (ABC) transporter ES963_05420 ENOG4105BZ1 (ABC) transporter ES963_05445 ENOG410839P ES963_05455 ENOG4106MP8 UPF0754 membrane protein ES963_05460 ENOG4105WZB UPF0342 protein ES963_05465 ENOG4105F1N DNA alkylation repair ES963_05475 ENOG4105D4P Coproporphyrinogen iii oxidase ES963_05480 ENOG4107S91 Sodium hydrogen exchanger ES963_05485 ENOG4105NCW Trka-c domain protein ES963_05495 ENOG4105CGU Enoyl-CoA hydratase ES963_05505 ENOG4108IUX (ABC) transporter ES963_05510 ENOG4105RHA ABC transporter, permease ES963_05515 ENOG4107VRP DNA repair exonuclease ES963_05520 ENOG4106D4I domain protein ES963_05525 ENOG4105EQI Metal Dependent Phosphohydrolase ES963_05535 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) ES963_05580 ENOG4105NBU tryptophan transport protein ES963_05585 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) ES963_05590 ENOG4105K59 histidine triad (HIT) protein ES963_05625 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation ES963_05630 ENOG4105BZ4 penicillin-binding protein ES963_05635 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) ES963_05640 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) ES963_05645 ENOG4105C1Q protoporphyrinogen oxidase ES963_05655 ENOG4105ECB domain protein ES963_05665 ENOG41090T1 Membrane ES963_05675 ENOG4105DER m42 family ES963_05690 ENOG4106AXD ES963_05695 ENOG4108RQ5 Beta-lactamase domain-containing protein ES963_05700 ENOG4105DF9 Lipoate-protein, ligase ES963_05710 ENOG4105CEY Amp-dependent synthetase and ligase ES963_05720 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 ES963_05730 ENOG4105KD7 acetyltransferase ES963_05740 ENOG4108HUF Transporter ES963_05745 ENOG4107TB6 phosphoglycerate mutase ES963_05755 ENOG4107F3J Amp-dependent synthetase and ligase ES963_05760 ENOG4107ZYJ bioY protein ES963_05765 ENOG4106YBV Methyl-accepting chemotaxis ES963_05785 ENOG4105XVF Competence transcription factor ES963_05790 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ES963_05795 ENOG4105X3H Excalibur domain protein ES963_05800 ENOG4105E1V na solute symporter ES963_05805 ENOG4106CAD Protein of unknown function (DUF3311) ES963_05810 ENOG41060YP ES963_05825 ENOG4107SCK Monooxygenase ES963_05830 ENOG4108INS Transcriptional regulator ES963_05850 ENOG4105TRI Hydrolase ES963_05865 ENOG4108KK1 membrane protein AbrB duplication ES963_05870 ENOG4106K7D Major facilitator family transporter ES963_05875 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) ES963_05880 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding ES963_05895 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation ES963_05905 ENOG4105EYH Exonuclease ES963_05955 ENOG4105ERH Fumarylacetoacetate hydrolase ES963_05965 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin ES963_05975 ENOG4105CAQ asparagine synthetase ES963_05985 ENOG4105UQX Mate efflux family protein ES963_05990 ENOG4106HBX Transcriptional Regulator AraC Family ES963_05995 ENOG4105ETE Transcriptional regulator (LacI family ES963_06000 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) ES963_06005 ENOG4105SF0 DinB family ES963_06010 ENOG4108ZUB Lysine exporter protein (Lyse ygga) ES963_06015 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ES963_06020 ENOG4105MYW Pentapeptide repeat protein ES963_06025 ENOG4107S9D Alpha beta hydrolase ES963_06030 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) ES963_06035 ENOG4107RIQ Sulfate adenylate transferase ES963_06040 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) ES963_06045 ENOG4108N5B 2-phosphosulfolactate phosphatase ES963_06050 ENOG41061P3 phosphosulfolactate synthase ES963_06060 ENOG4105DIA mandelate racemase muconate lactonizing ES963_06065 ENOG4107RCC Major Facilitator Superfamily ES963_06070 ENOG4108SZE gCN5-related N-acetyltransferase ES963_06075 ENOG4105MA6 gCN5-related N-acetyltransferase ES963_06085 ENOG4108VPT UPF0234 protein ES963_06090 ENOG4105QNR S1 RNA binding domain protein ES963_06110 ENOG4105K7K Transcriptional regulator ES963_06120 ENOG410751J ES963_06125 ENOG4105D4Y metalloprotease ES963_06130 ENOG4105EPR degv family ES963_06135 ENOG4107AYK membrAne ES963_06145 ENOG41073B9 ES963_06150 ENOG4108KP7 hydrolase ES963_06155 ENOG4108MXZ Esterase ES963_06160 ENOG4105VG1 fes assembly suf system protein ES963_06170 ENOG4105IQ5 FAD linked oxidase domain protein ES963_06180 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase ES963_06195 ENOG4105C8Y Acetylornithine aminotransferase ES963_06200 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain ES963_06210 ENOG4105DBV ornithine carbamoyltransferase ES963_06235 ENOG4107RMD Basic membrane lipoprotein ES963_06250 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) ES963_06255 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ES963_06265 ENOG4105C3U ABC transporter ES963_06270 ENOG4108JQ7 (ABC) transporter ES963_06285 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ES963_06295 ENOG4105C31 Tryptophanyl-tRNA synthetase ES963_06300 ENOG4108J59 Extracellular solute-binding protein, family 5 ES963_06305 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ES963_06310 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ES963_06320 ENOG4108JQ7 (ABC) transporter ES963_06335 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) ES963_06340 ENOG4108ZCF integral membrane protein ES963_06350 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis ES963_06365 ENOG4105DPN Oligoendopeptidase f ES963_06380 ENOG4105T58 Dithiol-disulfide isomerase ES963_06385 ENOG4108Z18 K06886 hemoglobin ES963_06390 ENOG4105E4C Lytic transglycosylase catalytic ES963_06395 ENOG4105MIX Adenylate cyclase ES963_06410 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) ES963_06415 ENOG4105EMS pseudouridine synthase ES963_06430 ENOG4105ETU transcriptional activator (TenA ES963_06435 ENOG4108VEU Thiamine monophosphate synthase ES963_06450 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) ES963_06455 ENOG4105D06 uba thif-type nad fad binding protein ES963_06460 ENOG4105DWF phosphomethylpyrimidine kinase ES963_06465 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH ES963_06470 ENOG4107A88 ES963_06520 ENOG4105ENA helicase ES963_06535 ENOG4108ZMI UPF0477 protein ES963_06545 ENOG4105C28 cystathionine ES963_06550 ENOG4105C28 cystathionine ES963_06555 ENOG4105D9U N-acetyltransferase ES963_06560 ENOG4105JHY Membrane ES963_06620 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) ES963_06655 ENOG410780I phosphoprotein phosphatase activity ES963_06660 ENOG4106BHF ES963_06665 ENOG4106ANW SMI1_KNR4 ES963_06735 ENOG4105DM4 PTS System ES963_06740 ENOG4105DG6 mannose-6-phosphate isomerase ES963_06745 ENOG4105G7B Protein of unknown function (DUF2992) ES963_06750 ENOG4105VMI -acetyltransferase ES963_06760 ENOG4108Z66 YbaK ebsC protein ES963_06780 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) ES963_06790 ENOG4108ZJ4 polysaccharide deacetylase ES963_06795 ENOG4107CUJ Protein of unknown function (DUF2690) ES963_06820 ENOG4108IEG Formate dehydrogenase Alpha subunit ES963_06845 ENOG4106A3M Cytochrome p-450 ES963_06850 ENOG41087PP glycosyltransferase MGT family ES963_06860 ENOG4105EXQ uroporphyrinogen iii synthase hem4 ES963_06865 ENOG4105C4B ABC transporter, permease ES963_06870 ENOG4108IXI (ABC) transporter ES963_06880 ENOG4105Q95 Cupin 2, conserved barrel domain protein ES963_06895 ENOG4105D2H Uronic isomerase ES963_06900 ENOG4105CT4 transporter ES963_06905 ENOG4105DG4 malate L-lactate dehydrogenase ES963_06910 ENOG4105CPQ Dehydrogenase ES963_06915 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) ES963_06920 ENOG4105DMW Dehydrogenase reductase ES963_06925 ENOG4108I5G Major Facilitator superfamily ES963_06930 ENOG4107KJX Transcriptional regulator ES963_06935 ENOG4107QZW Altronate oxidoreductase ES963_06940 ENOG4105CTX dehydratase ES963_06945 ENOG4107TSN permease ES963_06955 ENOG4105JD4 ATPase yjob ES963_06970 ENOG41068K0 YCII-related domain ES963_06975 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase ES963_06980 ENOG4105KWG Pfam:DUF1696 ES963_06985 ENOG4105K7W phage-related replication protein ES963_06990 ENOG4105WEF catalase ES963_06995 ENOG410635T phage-like element pbsx protein ES963_07040 ENOG4108TFU terminase (Small subunit) ES963_07045 ENOG4105IG6 Phage terminase, large subunit ES963_07050 ENOG4108MDF Phage Portal Protein ES963_07075 ENOG41060SN ES963_07090 ENOG4105PQS phage protein ES963_07095 ENOG4105FR7 XkdM protein, phage-like element PBSX ES963_07100 ENOG4105MTC XkdN-like protein ES963_07110 ENOG4108FKH Transglycosylase SLT domain ES963_07110 ENOG4108FKH Transglycosylase SLT domain ES963_07110 ENOG4108FKH Transglycosylase SLT domain ES963_07115 ENOG4108WZM domain protein ES963_07120 ENOG4105X7F ES963_07130 ENOG4105MFU Protein of unknown function (DUF2634) ES963_07135 ENOG41066EA baseplate J family protein ES963_07140 ENOG410906S phage-like element pbsx protein xkdt ES963_07150 ENOG41068G1 ES963_07180 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase ES963_07200 ENOG4105CJ3 phosphate transporter ES963_07205 ENOG4107GRR phosphate transport regulator ES963_07210 ENOG4107R7I amino acid ES963_07220 ENOG4105EDW glycosyl transferase, family 39 ES963_07225 ENOG4105CKK Glycosyl transferase, family 2 ES963_07230 ENOG4105C0H protease ES963_07240 ENOG4108ME1 Peptidase M55 D-aminopeptidase ES963_07245 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ES963_07250 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ES963_07255 ENOG4105C3U ABC transporter ES963_07265 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A ES963_07270 ENOG4105DTQ mandelate racemase muconate lactonizing ES963_07275 ENOG4107SN7 NLP P60 protein ES963_07280 ENOG4108JQ7 (ABC) transporter ES963_07285 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) ES963_07290 ENOG4107TUM Amidinotransferase ES963_07295 ENOG4108S4H thioesterase Superfamily protein ES963_07300 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ES963_07320 ENOG4108428 Inherit from COG: -acetyltransferase ES963_07330 ENOG41080TC multidrug resistance protein ES963_07335 ENOG4105CIY formyltetrahydrofolate deformylase ES963_07340 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) ES963_07355 ENOG4105K56 Transcriptional regulator ES963_07360 ENOG4108ZHJ Organic hydroperoxide resistance protein ES963_07370 ENOG4107Y2X deaminase ES963_07375 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) ES963_07380 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin ES963_07390 ENOG4108W7F transporter, permease ES963_07395 ENOG4108JJB ABC transporter ES963_07400 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein ES963_07405 ENOG4108X43 YKOF domain protein ES963_07410 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ES963_07415 ENOG41062D9 Histidine kinase ES963_07425 ENOG4106849 propeptide, pepSY amd peptidase M4 ES963_07440 ENOG4105CJW magnesium transporter ES963_07445 ENOG4105V75 Transcriptional regulator ES963_07490 ENOG4105DQE DNA ligase ES963_07495 ENOG4105FDF Could be involved in DNA repair (By similarity) ES963_07500 ENOG4105BZU Histidine kinase ES963_07505 ENOG4107T5V SNARE associated Golgi ES963_07510 ENOG4107TS3 membrane protein, TerC ES963_07515 ENOG4108WZW RNA polymerase sigma ES963_07525 ENOG410681C small acid-soluble spore protein ES963_07535 ENOG4105D0M Protease HtpX homolog ES963_07555 ENOG4108TGC Acyltransferase ES963_07560 ENOG4105BZU Histidine kinase ES963_07565 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ES963_07575 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) ES963_07580 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) ES963_07585 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase ES963_07595 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit ES963_07600 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) ES963_07605 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) ES963_07610 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) ES963_07630 ENOG4105BZU Histidine kinase ES963_07635 ENOG41090MY MarR family Transcriptional regulator ES963_07640 ENOG4105ER2 Ompa motb domain protein ES963_07645 ENOG4105E14 MotA TolQ exbB proton channel ES963_07655 ENOG4108K88 Membrane ES963_07660 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) ES963_07665 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase ES963_07670 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) ES963_07675 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) ES963_07685 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr ES963_07745 ENOG4107RRE RNA-directed DNA polymerase ES963_07770 ENOG4105F0V Cell wall hydrolase ES963_07785 ENOG4105C59 p-type ATPase ES963_07795 ENOG4105DC7 peptidase M24 ES963_07805 ENOG4105CID antiterminator ES963_07815 ENOG4105KRI phosphocarrier protein (HPr ES963_07820 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) ES963_07830 ENOG4105F6S Spore photoproduct lyase ES963_07840 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer ES963_07845 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ES963_07850 ENOG4105K4I Scp-like extracellular ES963_07860 ENOG4105BZU Histidine kinase ES963_07865 ENOG4105CHM Aminotransferase ES963_07875 ENOG4107R88 Chemotaxis protein (CheV) ES963_07880 ENOG4105UIN ES963_07890 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein ES963_07900 ENOG4105K6S Short-chain dehydrogenase reductase Sdr ES963_07905 ENOG4105EPM Diguanylate phosphodiesterase ES963_07910 ENOG4107IN1 Protein of unknown function (DUF1797) ES963_07915 ENOG4108XRC Protein of unknown function (DUF458) ES963_07945 ENOG4105NQC Flavodoxin ES963_07955 ENOG4105CH2 amidohydrolase ES963_07965 ENOG4105D8X mechanosensitive ion channel ES963_07970 ENOG4105D3R alkyl hydroperoxide reductase ES963_07975 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ES963_07990 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) ES963_07995 ENOG4105D06 uba thif-type nad fad binding protein ES963_08000 ENOG4105CVM Molybdenum cofactor synthesis domain protein ES963_08005 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein ES963_08010 ENOG4108ZAF Molybdopterin ES963_08015 ENOG41067WU Molybdopterin converting factor (Subunit 1) ES963_08020 ENOG4105BZ1 (ABC) transporter ES963_08025 ENOG4105BZ1 (ABC) transporter ES963_08035 ENOG4107X8C Efflux transporter RND family MFP subunit ES963_08040 ENOG4105C19 ABC transporter ES963_08045 ENOG4107RBB ABC transporter, permease ES963_08050 ENOG4105E98 transcriptional regulator DeoR family ES963_08055 ENOG4105DE4 1-phosphofructokinase ES963_08060 ENOG4105DM4 PTS System ES963_08065 ENOG4105C3F Signal peptidase i ES963_08075 ENOG4105C5H ABC transporter ES963_08080 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) ES963_08105 ENOG4105BZU Histidine kinase ES963_08115 ENOG4107ZYR domain protein ES963_08125 ENOG4105CN5 Metallo-Beta-Lactamase ES963_08135 ENOG4108X4Q Hydrolase ES963_08140 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ES963_08160 ENOG4105CPP Dehydrogenase, E1 component ES963_08165 ENOG4105C7S Dehydrogenase ES963_08170 ENOG4107QN2 dihydrolipoyl dehydrogenase ES963_08185 ENOG4105CXN decarboxylase ES963_08190 ENOG4105WBI UPF0223 protein ES963_08205 ENOG4105ECY inositol monophosphatase ES963_08215 ENOG4105JQZ Methyltransferase ES963_08255 ENOG4105CI3 gtp-binding protein typa ES963_08260 ENOG4105QA2 ES963_08275 ENOG4108IAB Phoh family ES963_08285 ENOG4105CSV Glutaminase ES963_08290 ENOG4105ZPI UPF0358 protein ES963_08295 ENOG4105CNI cell division protein FtsW ES963_08300 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) ES963_08310 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) ES963_08320 ENOG4105BZ9 Cytochrome C oxidase, subunit I ES963_08325 ENOG4105CCU oxidase (Subunit III) ES963_08330 ENOG41064X9 cytochrome C oxidase subunit IV ES963_08345 ENOG41080XQ Signal transduction protein with cbs domains ES963_08350 ENOG4106UY4 Inherit from COG: Scp-like extracellular ES963_08370 ENOG4105WUC UPF0298 protein ES963_08375 ENOG4106H78 methyltransferase ES963_08380 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) ES963_08385 ENOG4105H20 Sporulation integral membrane protein YlbJ ES963_08390 ENOG4105D78 K07001 NTE family protein ES963_08395 ENOG41063PX domain protein ES963_08400 ENOG4105CDE UPF0348 protein ES963_08410 ENOG4105KNH Nucleic acid-binding protein ES963_08415 ENOG41067VY 50S ribosomal protein L32 ES963_08440 ENOG4108V6E Cell division protein mraZ ES963_08445 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) ES963_08455 ENOG4105CJN penicillin-binding protein ES963_08460 ENOG4105CJN penicillin-binding protein ES963_08465 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) ES963_08470 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) ES963_08475 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) ES963_08480 ENOG4105CNI cell division protein FtsW ES963_08485 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) ES963_08490 ENOG4105D4A Cell wall formation (By similarity) ES963_08495 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) ES963_08500 ENOG4108R2U division initiation protein ES963_08510 ENOG4105K67 small basic protein ES963_08515 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) ES963_08520 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) ES963_08530 ENOG4105FFI sigma-e processing peptidase spoiiga ES963_08535 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ES963_08545 ENOG4105DKW ABC transporter ES963_08555 ENOG4105WR5 sporulation protein, YlmC YmxH family ES963_08560 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase ES963_08565 ENOG4105DFA alanine racemase domain protein ES963_08570 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) ES963_08575 ENOG41067XK integral membrane protein ES963_08580 ENOG4105DBK s4 domain protein ES963_08590 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) ES963_08600 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) ES963_08605 ENOG4105C34 Pseudouridine synthase ES963_08610 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) ES963_08620 ENOG4105CXT aspartate transcarbamylase ES963_08630 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain ES963_08635 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain ES963_08640 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) ES963_08645 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) ES963_08650 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) ES963_08655 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) ES963_08660 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) ES963_08670 ENOG4107S4M Sulfate adenylate transferase ES963_08675 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) ES963_08680 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) ES963_08685 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein ES963_08690 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein ES963_08695 ENOG4105F23 Fibronectin-binding protein ES963_08705 ENOG4105DSJ YicC domain protein ES963_08710 ENOG4105KC4 UPF0296 protein ES963_08715 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) ES963_08725 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase ES963_08730 ENOG4105C25 Primosomal protein n' ES963_08735 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) ES963_08740 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) ES963_08745 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B ES963_08750 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs ES963_08755 ENOG4108ZF3 Phosphatase ES963_08760 ENOG4105D9P serine threonine protein kinase ES963_08765 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) ES963_08770 ENOG4105DJV ribulose-phosphate 3-epimerase ES963_08775 ENOG4105FJ0 thiamine ES963_08785 ENOG4105VB9 50S ribosomal protein l28 ES963_08790 ENOG4108ZAA Alkaline-shock protein ES963_08795 ENOG4105DP4 dak2 domain fusion protein ylov ES963_08805 ENOG4105EJQ L-serine dehydratase ES963_08810 ENOG4105CB5 ATP-dependent DNA helicase recG ES963_08815 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) ES963_08825 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase ES963_08830 ENOG4105CHR reductase ES963_08835 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) ES963_08840 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) ES963_08845 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) ES963_08850 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ES963_08860 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) ES963_08870 ENOG4105K5M 30s ribosomal protein S16 ES963_08875 ENOG4108BW8 UPF0109 protein ES963_08885 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) ES963_08890 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) ES963_08895 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) ES963_08900 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) ES963_08905 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ES963_08915 ENOG4105VM1 flagellar ES963_08920 ENOG4105CMV Succinyl-CoA synthetase subunit beta ES963_08925 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha ES963_08930 ENOG4105C79 DNA protecting protein DprA ES963_08935 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) ES963_08940 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) ES963_08945 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ES963_08950 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) ES963_08955 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) ES963_08965 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) ES963_08970 ENOG4108ZC9 flagellar basal-body rod protein flgc ES963_08975 ENOG4105VQ0 flagellar hook-basal body complex protein fliE ES963_08980 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) ES963_08985 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) ES963_09000 ENOG4106YF4 Flagellar biosynthesis chaperone ES963_09010 ENOG410696Y Flagellar hook-length control protein ES963_09015 ENOG410822I Flagellar hook capping protein ES963_09020 ENOG4108JQA flagellar ES963_09025 ENOG41068WV flagellar FlbD family protein ES963_09035 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) ES963_09040 ENOG4105DD5 Flagellar motor switch protein ES963_09045 ENOG4107YTP response regulator receiver protein ES963_09055 ENOG4105CN7 Flagellar biosynthetic protein FliP ES963_09060 ENOG4105VS8 Flagellar biosynthetic protein fliq ES963_09065 ENOG4105D19 Role in flagellar biosynthesis (By similarity) ES963_09070 ENOG4105D00 flagellar biosynthetic protein flhB ES963_09075 ENOG4105D7B Flagellar biosynthesis protein flha ES963_09080 ENOG4105FZW flagellar biosynthesis regulator FlhF ES963_09090 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) ES963_09095 ENOG4105CBS Chea signal transduction histidine kinase ES963_09100 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis ES963_09115 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ES963_09125 ENOG4105CE9 30S ribosomal protein S2 ES963_09130 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) ES963_09140 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) ES963_09145 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) ES963_09150 ENOG4105KNE Phosphatidate cytidylyltransferase ES963_09160 ENOG4105DZP Membrane-associated zinc metalloprotease ES963_09165 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) ES963_09170 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) ES963_09175 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) ES963_09180 ENOG4105CHV Transcription elongation factor NusA ES963_09185 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination ES963_09190 ENOG4105VHM ribosomal protein ES963_09195 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) ES963_09200 ENOG4105W7A Protein of unknown function (DUF503) ES963_09205 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) ES963_09210 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) ES963_09215 ENOG4105DTN riboflavin biosynthesis protein ribF ES963_09220 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) ES963_09225 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) ES963_09235 ENOG4105C1V Peptidase, M16 ES963_09245 ENOG4105E35 Dipicolinate synthase subunit A ES963_09250 ENOG4108S0H Dipicolinic acid synthetase, b subunit ES963_09255 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) ES963_09265 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ES963_09275 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit ES963_09285 ENOG4105CNU cell division protein FtsK ES963_09290 ENOG4105FDP GntR family transcriptional regulator ES963_09310 ENOG4108RKS Short-chain dehydrogenase reductase Sdr ES963_09315 ENOG4105XZV Protein of unknown function (DUF3243) ES963_09330 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase ES963_09335 ENOG4105CEV competence damage-inducible protein ES963_09345 ENOG4108A04 Beta-lactamase ES963_09350 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) ES963_09355 ENOG4105D48 metallophosphoesterase ES963_09360 ENOG4105MCT stage V sporulation protein S ES963_09370 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) ES963_09375 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) ES963_09390 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) ES963_09395 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) ES963_09470 ENOG4105IIP Membrane ES963_09475 ENOG4105W1N transcriptional regulator ES963_09490 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin ES963_09495 ENOG4105K7W phage-related replication protein ES963_09500 ENOG4108X3M OsmC Ohr family protein ES963_09505 ENOG410814C multidrug resistance protein ES963_09525 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) ES963_09530 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) ES963_09545 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) ES963_09550 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ES963_09555 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ES963_09560 ENOG4105U6W MutT NUDIX family protein ES963_09565 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase ES963_09575 ENOG4106F1P AAA ATPase, central domain protein ES963_09580 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) ES963_09585 ENOG4105CXI aluminum resistance protein ES963_09590 ENOG4105KV4 Transcriptional regulator ES963_09595 ENOG4105C5F glutamine synthetase ES963_09600 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ES963_09620 ENOG4108ZUE Phage regulatory protein rha ES963_09755 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ES963_09800 ENOG4108FKH Transglycosylase SLT domain ES963_09810 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj ES963_09820 ENOG41068G1 ES963_09840 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase ES963_09850 ENOG4106BHF ES963_09855 ENOG410780I phosphoprotein phosphatase activity ES963_09870 ENOG41079P0 ES963_09915 ENOG4107NTZ ES963_09940 ENOG410907G ES963_09945 ENOG4105CT4 transporter ES963_09950 ENOG4105DSG hydrolase family 43 ES963_09955 ENOG4105E2R ROK family ES963_09960 ENOG4105C93 Xylose Isomerase ES963_09965 ENOG4105CMG Carbohydrate kinase ES963_09975 ENOG4107Y9E nuclease ES963_09980 ENOG4105C54 Major Facilitator superfamily ES963_09985 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ES963_09995 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) ES963_10080 ENOG4105FVX ES963_10090 ENOG4105K7W phage-related replication protein ES963_10100 ENOG4105I9P Metallothiol transferase which confers resistance to fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin. L-cysteine is probably the physiological thiol donor (By similarity) ES963_10110 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) ES963_10120 ENOG4108SVB resolvase ES963_10125 ENOG4105VPS UPF0291 protein ES963_10130 ENOG4105CV1 Transketolase (EC 2.2.1.1) ES963_10150 ENOG4107QIV Cytochrome c biogenesis protein ES963_10175 ENOG4107DZX Small, acid-soluble spore protein P ES963_10185 ENOG4108I0Z Aconitate hydratase ES963_10190 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ES963_10205 ENOG41067CD Small, acid-soluble spore protein Tlp ES963_10215 ENOG4105MI2 ES963_10220 ENOG4105W8X HesB YadR YfhF-family protein ES963_10225 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) ES963_10230 ENOG4105K4P CoA-binding domain protein ES963_10235 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ES963_10255 ENOG4107QWR cellulase (EC 3.2.1.4) ES963_10265 ENOG4108MYR Secreted protein ES963_10285 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase ES963_10290 ENOG4107T5V SNARE associated Golgi ES963_10300 ENOG4107QX3 carboxylase ES963_10305 ENOG4105E39 Enoyl-CoA hydratase ES963_10310 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase ES963_10315 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit ES963_10320 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase ES963_10325 ENOG4105CEY Amp-dependent synthetase and ligase ES963_10330 ENOG4105C1G acyl-Coa dehydrogenase ES963_10345 ENOG4105F32 YngK protein ES963_10350 ENOG4106U2H Protein of unknown function (DUF1360) ES963_10360 ENOG4105CEY Amp-dependent synthetase and ligase ES963_10365 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family ES963_10370 ENOG4108N2V aldose 1-epimerase ES963_10375 ENOG4107QJQ Mate efflux family protein ES963_10400 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) ES963_10405 ENOG4105SKE transcriptional Regulator LysR family ES963_10410 ENOG4105CB2 alcohol dehydrogenase ES963_10415 ENOG4105BZ8 glutamate synthase ES963_10420 ENOG4105CBC glutamate synthase ES963_10425 ENOG4105C5Q Transcriptional regulator ES963_10430 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) ES963_10435 ENOG4105II7 pyrroline-5-carboxylate reductase ES963_10455 ENOG4108UB7 ES963_10460 ENOG41068WN ES963_10465 ENOG4105IE8 Alpha-ketoglutarate permease ES963_10470 ENOG4107U6E carbohydrate kinase FGGY ES963_10475 ENOG4108M3J Dehydrogenase ES963_10480 ENOG4108J2R molybdopterin oxidoreductase ES963_10490 ENOG4107QNK )-transporter ES963_10495 ENOG4105CIB oxidoreductase Domain protein ES963_10500 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) ES963_10505 ENOG4105ETE Transcriptional regulator (LacI family ES963_10525 ENOG4105EC8 Methyl-accepting chemotaxis ES963_10540 ENOG4105XPP Protein of unknown function (DUF1275) ES963_10545 ENOG4108NR7 pectate lyase ES963_10550 ENOG4108RAV Conserved protein ES963_10560 ENOG4105F0F Oxalate decarboxylase ES963_10585 ENOG41073R8 VanW family ES963_10600 ENOG4105NX3 Membrane ES963_10610 ENOG4108Q5Y Membrane ES963_10620 ENOG4108V4B ThiJ pfpI ES963_10625 ENOG4108J4B Beta-lactamase ES963_10655 ENOG4107T94 Endo-14-beta-xylanase ES963_10665 ENOG4105YB8 TM2 domain containing protein ES963_10785 ENOG4105D9U N-acetyltransferase ES963_10795 ENOG4105D06 uba thif-type nad fad binding protein ES963_10800 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ES963_10850 ENOG4106ANW SMI1_KNR4 ES963_10855 ENOG4106BHF ES963_10870 ENOG4108Z7R Chaperone CsaA ES963_10875 ENOG4105FTV AraC Family Transcriptional Regulator ES963_10880 ENOG4108HJF gCN5-related N-acetyltransferase ES963_10890 ENOG4108W8B Beta-lactamase domain protein ES963_10900 ENOG4105D29 Helix-turn-helix type 11 domain protein ES963_10910 ENOG4105KTU Transcriptional regulator, arsr family ES963_10920 ENOG4108SJC Membrane ES963_10940 ENOG4105ECK Fatty Acid Desaturase ES963_10945 ENOG4108ZGX Histidine kinase ES963_10950 ENOG4108S01 response regulator ES963_10955 ENOG41069ER domain protein ES963_10960 ENOG4105C9U ATP-dependent DNA helicase RecQ ES963_10975 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) ES963_10980 ENOG4105SCY DNAK suppressor ES963_11020 ENOG4105C26 Dehydrogenase ES963_11025 ENOG4105EWU Squalene--hopene cyclase ES963_11030 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ES963_11035 ENOG4105C8J )-transporter ES963_11040 ENOG4105C09 Bile acid ES963_11045 ENOG4105C7S Dehydrogenase ES963_11055 ENOG4107T89 von Willebrand factor, type A ES963_11060 ENOG4105GMT ATPase associated with various cellular activities aaa_5 ES963_11070 ENOG4105K4H Nlp p60 protein ES963_11075 ENOG41087PP glycosyltransferase MGT family ES963_11085 ENOG4107QMU Mate efflux family protein ES963_11090 ENOG4106SCS STAS domain ES963_11110 ENOG4105FR1 rard protein ES963_11130 ENOG41090U3 tautomerase ES963_11145 ENOG4105FBA Phospholipase Carboxylesterase ES963_11160 ENOG4105E1V na solute symporter ES963_11180 ENOG4108VXD carboxy-peptidase ES963_11185 ENOG4105D3A purine nucleoside phosphorylase DeoD-type ES963_11195 ENOG4106Z5R ES963_11200 ENOG410841Q phosphoesterase PA-phosphatase related protein ES963_11235 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein ES963_11240 ENOG4108TSC N-acetyltransferase ES963_11245 ENOG4107S4Y M20 DapE family protein YgeY ES963_11260 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ES963_11300 ENOG4107T32 3-phytase (EC 3.1.3.8) ES963_11305 ENOG4105C5E polysaccharide biosynthesis protein ES963_11310 ENOG4105E0X reductase ES963_11315 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) ES963_11335 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) ES963_11340 ENOG41090WU lipolytic protein G-D-S-L family ES963_11345 ENOG4108KF3 Electron transport protein SCO1 SenC ES963_11355 ENOG4105C7B Threonine dehydratase ES963_11365 ENOG4108UT2 hemolysin iii ES963_11375 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) ES963_11390 ENOG4107YX5 Pfam:DUF548 ES963_11395 ENOG4108Y6J UPF0403 protein ES963_11400 ENOG4105C01 Dihydroxy-acid dehydratase ES963_11415 ENOG4108V06 Glutathione peroxidase ES963_11420 ENOG4105CVG Homoserine O-transsuccinylase ES963_11465 ENOG41081VK Ribonuclease ES963_11490 ENOG410890F Dynamin family ES963_11505 ENOG41065KQ synthase ES963_11510 ENOG4105C2W permease ES963_11515 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) ES963_11520 ENOG4105CTD carboxy-peptidase ES963_11525 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) ES963_11530 ENOG4108UHU Aldolase ES963_11535 ENOG4105D7K pfkb domain protein ES963_11540 ENOG4108M60 Transcriptional regulator ES963_11550 ENOG4105CHR reductase ES963_11555 ENOG4105DVT helicase ES963_11570 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) ES963_11585 ENOG4108UKS UPF0398 protein ES963_11600 ENOG4107X2U Inherit from COG: Exonuclease-like protein ES963_11605 ENOG4108I5C dEAD DEAH box helicase ES963_11655 ENOG4105BZ4 penicillin-binding protein ES963_11665 ENOG4105CSM endonuclease III ES963_11675 ENOG4105C5S asparaginyl-tRNA synthetase ES963_11680 ENOG4105CHM Aminotransferase ES963_11690 ENOG4105YAC ES963_11695 ENOG4105DVT helicase ES963_11700 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) ES963_11705 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) ES963_11710 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) ES963_11715 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase ES963_11720 ENOG4105DJ0 Poly(A) Polymerase ES963_11725 ENOG4105CPK Glycosyl transferase (Group 1 ES963_11730 ENOG4105FJR Lmbe family ES963_11735 ENOG4108Z5K methylglyoxal synthase ES963_11740 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) ES963_11745 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase ES963_11750 ENOG4108JYZ YitT family ES963_11770 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) ES963_11790 ENOG41068YB TPR repeat-containing protein ES963_11795 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase ES963_11815 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) ES963_11820 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase ES963_11830 ENOG4108I0Q anthranilate phosphoribosyltransferase ES963_11835 ENOG4105CRQ synthase (Component I) ES963_11840 ENOG4105KHN chorismate mutase ES963_11845 ENOG4105D49 3-dehydroquinate synthase ES963_11850 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase ES963_11855 ENOG4105BZU Histidine kinase ES963_11860 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) ES963_11865 ENOG4105EAH synthase ES963_11870 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) ES963_11875 ENOG4105XXQ heptaprenyl diphosphate synthase component I ES963_11885 ENOG4105EUJ GTP cyclohydrolase i ES963_11890 ENOG4105K70 DNA-binding protein ES963_11895 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) ES963_11910 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase ES963_11915 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) ES963_11920 ENOG41065D1 ES963_11925 ENOG4105S2F ES963_11940 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) ES963_11945 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) ES963_11950 ENOG4105CAT Cytidine monophosphate kinase ES963_11965 ENOG4105MSI germination protein ypeb ES963_11975 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) ES963_11980 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase ES963_11995 ENOG4107RGJ metallophosphoesterase ES963_12010 ENOG4105I7S Abortive infection protein ES963_12015 ENOG4105C9U ATP-dependent DNA helicase RecQ ES963_12020 ENOG4105T7X ES963_12030 ENOG4108SAX Membrane ES963_12035 ENOG4108JQ1 Dehydrogenase ES963_12040 ENOG4105FF2 Type I DHQase ES963_12055 ENOG4105BZU Histidine kinase ES963_12060 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ES963_12065 ENOG4105CRE cytochrome C ES963_12070 ENOG4107TWT Cytochrome c biogenesis protein ES963_12080 ENOG4105FE9 pseudouridine synthase ES963_12090 ENOG4108JIC nucleoside recognition domain protein ES963_12095 ENOG4105DZ1 carboxypeptidase ES963_12105 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) ES963_12110 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) ES963_12125 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) ES963_12130 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) ES963_12135 ENOG4108R6K riboflavin synthase, subunit alpha ES963_12140 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) ES963_12150 ENOG4105C3F Signal peptidase i ES963_12155 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) ES963_12190 ENOG4107ZE5 PPIases accelerate the folding of proteins ES963_12200 ENOG4105PTM secreted protein ES963_12205 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) ES963_12215 ENOG4105G6R Stage v sporulation protein ae ES963_12225 ENOG4105CZ3 stage V sporulation protein ad ES963_12230 ENOG41090VF Stage v sporulation protein ac ES963_12245 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ES963_12250 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) ES963_12255 ENOG41082AN stage II sporulation protein ES963_12260 ENOG4105DZ1 carboxypeptidase ES963_12265 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) ES963_12270 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) ES963_12275 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ES963_12285 ENOG4105I3K Ferric uptake regulator, Fur family ES963_12290 ENOG4105MZ9 stage II sporulation protein m ES963_12305 ENOG4105DFD Na H antiporter ES963_12310 ENOG4108IJ0 Aspartate ammonia-lyase ES963_12315 ENOG4105HDK L-asparaginase ES963_12320 ENOG4108IMY Transcriptional regulator ES963_12330 ENOG4108YZ4 nudix hydrolase ES963_12340 ENOG4105CPC Aldo Keto reductase ES963_12360 ENOG4106HZJ ES963_12365 ENOG4105RHY Pfam:UPF0157 ES963_12370 ENOG4105KAC Antibiotic biosynthesis monooxygenase ES963_12375 ENOG4108XET gCN5-related N-acetyltransferase ES963_12385 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) ES963_12395 ENOG4105E5W Transporter ES963_12400 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase ES963_12415 ENOG4108IXY short-chain dehydrogenase reductase ES963_12420 ENOG41069FQ Metallo-beta-lactamase superfamily ES963_12425 ENOG4105II7 pyrroline-5-carboxylate reductase ES963_12435 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ES963_12445 ENOG410861F 50S ribosomal protein L33 ES963_12450 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) ES963_12455 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase ES963_12460 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) ES963_12465 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) ES963_12475 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) ES963_12480 ENOG4108NA0 Uncharacterized conserved protein (COG2071) ES963_12485 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) ES963_12490 ENOG4108HNZ carboxyl transferase ES963_12495 ENOG4108ZVT methylmalonyl-coA epimerase ES963_12500 ENOG4108VZI ErfK ybiS ycfS ynhG family protein ES963_12505 ENOG4108QEG Membrane ES963_12510 ENOG4105CDA abc transporter atp-binding protein ES963_12515 ENOG4105E5Q amino acid AbC transporter ES963_12520 ENOG4108HW3 (ABC) transporter ES963_12525 ENOG4108Y6J UPF0403 protein ES963_12530 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) ES963_12545 ENOG4105C7S Dehydrogenase ES963_12550 ENOG4105CPP Dehydrogenase, E1 component ES963_12565 ENOG4105CKM Branched-chain carboxylic acid kinase ES963_12570 ENOG4107RDP Dehydrogenase ES963_12580 ENOG4108JUB Transcriptional regulator ES963_12585 ENOG4106CCJ Protein of unknown function (DUF2627) ES963_12590 ENOG4105CR4 methylisocitrate lyase ES963_12595 ENOG4105DXD 2-methylcitrate dehydratase ES963_12605 ENOG4105C1G acyl-Coa dehydrogenase ES963_12610 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ES963_12620 ENOG4108QXE glycerophosphoryl diester phosphodiesterase ES963_12625 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase ES963_12640 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ES963_12645 ENOG4107QQR Sporulation ES963_12655 ENOG4105S1Z Stage IV sporulation protein B ES963_12660 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) ES963_12665 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) ES963_12670 ENOG4105DX0 Hemolysin A ES963_12680 ENOG4105CTB Polyprenyl synthetase ES963_12685 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) ES963_12690 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) ES963_12695 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) ES963_12700 ENOG4105M7K Involved in the transcription termination process (By similarity) ES963_12705 ENOG4108ZSR alkaline shock protein ES963_12710 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase ES963_12730 ENOG410644B Stage III sporulation protein af ES963_12740 ENOG4105KQ4 Stage iii sporulation protein ad ES963_12745 ENOG4108CQH stage III sporulation protein AC ES963_12750 ENOG4105KR5 Stage iii sporulation protein ES963_12755 ENOG4105CD2 stage iii sporulation protein aa ES963_12765 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) ES963_12770 ENOG4105DC7 peptidase M24 ES963_12775 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) ES963_12785 ENOG4105CBJ Metal-dependent enzyme ES963_12800 ENOG4105KST dependent repressor ES963_12805 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) ES963_12810 ENOG4105WZW rhodanese family ES963_12815 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor ES963_12820 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor ES963_12825 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) ES963_12830 ENOG4105C0D helicase ES963_12845 ENOG4108IMY Transcriptional regulator ES963_12855 ENOG4105VFR signal peptidase ES963_12910 ENOG41080XP Cbs domain ES963_12920 ENOG4105C37 (CBS) domain ES963_12945 ENOG4105C5X domain protein ES963_12970 ENOG4105E0M Sulfatase ES963_12985 ENOG4107ZXI Rhomboid family ES963_12995 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase ES963_13000 ENOG4105WDJ 50S ribosomal protein L33 ES963_13020 ENOG41068DG YceG-like family ES963_13025 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) ES963_13030 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) ES963_13035 ENOG4105E2Z phosphate ABC transporter (Permease ES963_13040 ENOG4105C8U phosphate abc transporter ES963_13045 ENOG4105CVA phosphate ES963_13050 ENOG4107RF6 penicillin-binding protein ES963_13060 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ES963_13065 ENOG4105SXS Protein of unknown function (DUF456) ES963_13080 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) ES963_13085 ENOG41063Y9 ES963_13090 ENOG4108U5J '-nucleotidase ES963_13095 ENOG4105N80 Ferric uptake regulator, Fur family ES963_13100 ENOG4108JYZ YitT family ES963_13105 ENOG41069ZM Protein of unknown function (DUF2624) ES963_13110 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) ES963_13125 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) ES963_13130 ENOG4105EGD dinuclear metal center protein, YbgI family ES963_13150 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ES963_13155 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) ES963_13160 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 ES963_13165 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) ES963_13175 ENOG4105C38 Glycyl-tRNA synthetase beta subunit ES963_13180 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit ES963_13185 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) ES963_13195 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) ES963_13200 ENOG4105KG3 cytidine deaminase ES963_13205 ENOG4107YR5 Diacylglycerol kinase ES963_13210 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) ES963_13215 ENOG4105CTJ Metal Dependent Phosphohydrolase ES963_13220 ENOG4105C9A Phoh family ES963_13225 ENOG4105EI1 sporulation protein yqfd ES963_13230 ENOG41068P3 sporulation protein YqfC ES963_13240 ENOG4105DI5 UPF0365 protein ES963_13245 ENOG4105F7J membrane-bound serine protease ES963_13250 ENOG4105KTH gatB Yqey ES963_13265 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) ES963_13270 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) ES963_13275 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) ES963_13285 ENOG4105CFG Acts as a chaperone (By similarity) ES963_13290 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ ES963_13295 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) ES963_13300 ENOG4105CSA Coproporphyrinogen iii oxidase ES963_13305 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) ES963_13315 ENOG4108ZRV stage ii sporulation protein p ES963_13320 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) ES963_13325 ENOG41082YS Binds directly to 16S ribosomal RNA ES963_13330 ENOG4105TQK DNA polymerase iii, delta' subunit ES963_13345 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 ES963_13350 ENOG4108UK2 deaminase ES963_13355 ENOG4105KQC Competence protein ES963_13365 ENOG4108D32 Methyltransferase ES963_13375 ENOG4108WF2 Metal Dependent Phosphohydrolase ES963_13380 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) ES963_13385 ENOG410812S Rna-binding protein ES963_13390 ENOG4105E2X shikimate dehydrogenase ES963_13395 ENOG4105CQW ribosome biogenesis GTPase YqeH ES963_13400 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase ES963_13415 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase ES963_13420 ENOG41080BT SNARE associated Golgi ES963_13435 ENOG4105WFK nuclease ES963_13440 ENOG4105DMD Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ES963_13455 ENOG4105C9Q fumarate hydratase class II ES963_13600 ENOG41090E6 transcriptional regulator MERR family ES963_13615 ENOG4105C37 (CBS) domain ES963_13630 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family ES963_13635 ENOG4105H3G oxidoreductase ES963_13640 ENOG4105PGM cation diffusion facilitator family transporter ES963_13655 ENOG4105KMT branched-chain amino acid ES963_13660 ENOG4108UMN azlc family ES963_13665 ENOG4108ZRZ Transcriptional regulator (AsnC family) ES963_13670 ENOG41067XF inhibitor ES963_13690 ENOG41064BW Protein of unknown function (DUF2568) ES963_13705 ENOG41075D4 Aminoglycoside 6-adenylyltransferase ES963_13710 ENOG4105EA8 2-Nitropropane dioxygenase ES963_13725 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) ES963_13745 ENOG4108MEK Metal-binding protein YodA ES963_13750 ENOG410904A RNA polymerase ES963_13755 ENOG4105CPC Aldo Keto reductase ES963_13765 ENOG4108KAM Transcriptional regulator ES963_13770 ENOG4105C7F AcnD-accessory protein PrpF ES963_13775 ENOG41083Q9 chitosanase ES963_13780 ENOG4105X5K response regulator receiver protein ES963_13785 ENOG4108VQT Alpha beta hydrolase fold protein ES963_13790 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein ES963_13795 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein ES963_13805 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase ES963_13815 ENOG4105PGS Spore coat protein ES963_13820 ENOG4105E2A Dehydrogenase ES963_13835 ENOG4105VUF Transcriptional regulator ES963_13845 ENOG4105DQ4 alcohol dehydrogenase ES963_13850 ENOG4108Z0Z intracellular protease Pfpi family ES963_13855 ENOG4108HKT sucrose-6-phosphate hydrolase ES963_13860 ENOG4105F3R pts system mannose fructose sorbose family iid ES963_13865 ENOG4105ETZ PTS System ES963_13870 ENOG4108IQ3 PTS system ES963_13875 ENOG4105YHU PTS system ES963_13880 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ES963_13890 ENOG4105C85 amino acid ES963_13895 ENOG4105N14 lysine exporter protein LysE YggA ES963_13900 ENOG4108NGU Transcriptional regulator ES963_13905 ENOG4105JVQ RNA Polymerase ES963_13910 ENOG4108P49 AntiSigma factor ES963_13915 ENOG4105EXC Acyl-transferase ES963_13920 ENOG4105WDR ES963_13925 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) ES963_13930 ENOG41082JN Transcriptional regulator ES963_13950 ENOG4105TMB Formate nitrite transporter ES963_13955 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) ES963_13960 ENOG4108JB9 formate dehydrogenase ES963_13975 ENOG4105C28 cystathionine ES963_13990 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) ES963_14005 ENOG4107XRG penicillin-binding protein ES963_14010 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) ES963_14015 ENOG4105DBI uridine monophosphokinase ES963_14020 ENOG4105CFP Peptidase U32 ES963_14025 ENOG4105XYU peptidase (U32 family) ES963_14030 ENOG4108VQJ O-methyltransferase ES963_14035 ENOG4105HHA aminodeoxychorismate lyase ES963_14040 ENOG4105VPH UPF0473 protein ES963_14045 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) ES963_14050 ENOG4105VBH UPF0297 protein ES963_14055 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) ES963_14060 ENOG4105C02 permease ES963_14065 ENOG4105CDA abc transporter atp-binding protein ES963_14070 ENOG4105CT1 (ABC) transporter ES963_14075 ENOG4105EAD ABC transporter ES963_14080 ENOG4105DRP amino acid AbC transporter ES963_14090 ENOG41060CR ES963_14100 ENOG4105C7H Helicase, RecD TraA family ES963_14110 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) ES963_14115 ENOG4105C3J Cysteine desulfurase ES963_14125 ENOG4105D1H recombination factor protein RarA ES963_14130 ENOG4105CUZ uba thif-type nad fad binding protein ES963_14140 ENOG4105C9M aspartyl-trna synthetase ES963_14145 ENOG4105CUT histidyl-tRNA synthetase ES963_14155 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase ES963_14165 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ES963_14170 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) ES963_14175 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) ES963_14180 ENOG41067VP Protein of unknown function (DUF1049) ES963_14185 ENOG4105NCW Trka-c domain protein ES963_14190 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ES963_14200 ENOG4105CKP Polysaccharide Biosynthesis Protein ES963_14205 ENOG4108QG2 Membrane ES963_14210 ENOG4105NAP ES963_14215 ENOG4105VIE preprotein translocase, subunit YajC ES963_14220 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) ES963_14225 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) ES963_14230 ENOG41061AI Protein of unknown function (DUF2905) ES963_14235 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) ES963_14240 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) ES963_14250 ENOG4105IE8 Alpha-ketoglutarate permease ES963_14255 ENOG4105CK5 oxidoreductase ES963_14280 ENOG4105BZG amino acid carrier protein ES963_14285 ENOG4105CDY transcriptional regulatory protein ES963_14295 ENOG4106678 morphogenetic protein associated with SpoVID ES963_14300 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) ES963_14305 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase ES963_14310 ENOG4108IYU L-aspartate oxidase ES963_14325 ENOG4105CQC Prephenate dehydratase ES963_14330 ENOG41090I5 UPF0735 ACT domain-containing protein ES963_14335 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control ES963_14350 ENOG4105K46 50S ribosomal protein l27 ES963_14355 ENOG4105X36 (ribosomal) protein ES963_14360 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) ES963_14375 ENOG4107QMS site-determining protein ES963_14380 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) ES963_14385 ENOG4105YHC Rod shape-determining protein MreD ES963_14390 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) ES963_14395 ENOG4105DFF Rod shape-determining protein mreb ES963_14400 ENOG4105W5Q DNA repair protein (RadC ES963_14405 ENOG4108Z03 MAF-like protein ES963_14415 ENOG4106A3R peptidase ES963_14420 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase ES963_14425 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) ES963_14435 ENOG4106AR7 Spore coat protein ES963_14440 ENOG41068KH stage VI sporulation protein D ES963_14445 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase ES963_14450 ENOG4105D52 delta-aminolevulinic acid dehydratase ES963_14460 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) ES963_14470 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) ES963_14480 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) ES963_14485 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) ES963_14490 ENOG4108IUQ atp-dependent protease ES963_14495 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) ES963_14500 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation ES963_14510 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ES963_14515 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) ES963_14520 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) ES963_14525 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) ES963_14530 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase ES963_14535 ENOG4108ZP8 Acetolactate synthase small subunit ES963_14540 ENOG4105C7K acetolactate synthase ES963_14550 ENOG4105I4A GCN5-related N-acetyltransferase ES963_14555 ENOG4107KM7 Heat induced stress protein YflT ES963_14565 ENOG4105M59 Phosphodiesterase, mj0936 family ES963_14570 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) ES963_14575 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) ES963_14580 ENOG4108XJQ germination protein ES963_14585 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) ES963_14590 ENOG41067TZ transcriptional regulator, MarR family ES963_14595 ENOG4105PFC Transcriptional regulator ES963_14605 ENOG4105E33 succinate dehydrogenase ES963_14615 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit ES963_14625 ENOG4105CFH Aspartokinase ES963_14635 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) ES963_14640 ENOG4105K63 Thioredoxin ES963_14650 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) ES963_14655 ENOG4105C10 Electron transfer flavoprotein ES963_14660 ENOG4105BZJ Electron transfer flavoprotein ES963_14665 ENOG41060WC Enoyl-CoA hydratase ES963_14670 ENOG4107Z3H Transcriptional regulator, TetR family ES963_14675 ENOG4105CEY Amp-dependent synthetase and ligase ES963_14685 ENOG4105C98 muts2 protein ES963_14690 ENOG4105DCG PHP domain protein ES963_14705 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) ES963_14710 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) ES963_14715 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) ES963_14725 ENOG4108RWN rrna methyltransferase ES963_14730 ENOG41067MF small acid-soluble spore protein ES963_14740 ENOG4105CQB FAD linked oxidase domain protein ES963_14745 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) ES963_14765 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) ES963_14770 ENOG4105DRS transport system, permease ES963_14785 ENOG4108MDK Dehydrogenase ES963_14795 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase ES963_14800 ENOG4105EF1 ribulokinase ES963_14810 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase ES963_14815 ENOG4105CN9 Peptidase m42 family protein ES963_14825 ENOG410696E Membrane ES963_14830 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) ES963_14835 ENOG4105VJV 50s ribosomal protein L35 ES963_14840 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) ES963_14850 ENOG41067MG lrgb family ES963_14860 ENOG4105DY9 regulatoR ES963_14865 ENOG4108HRK Histidine kinase ES963_14870 ENOG4105U0R haloacid dehalogenase-like hydrolase ES963_14875 ENOG4105C22 threonyL-tRNA synthetase ES963_14880 ENOG4108TDW sporulation protein YtxC ES963_14900 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) ES963_14905 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) ES963_14910 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ES963_14925 ENOG4105CV8 reductase ES963_14930 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) ES963_14940 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) ES963_14945 ENOG4105C2M dna polymerase I ES963_14950 ENOG4105BZU Histidine kinase ES963_14955 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ES963_14960 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) ES963_14965 ENOG4108HMX isocitrate dehydrogenase (NADP) ES963_14970 ENOG4105BZN citrate synthase ES963_14980 ENOG4108REF Sporulation integral membrane protein ytvi ES963_14985 ENOG4105FS0 cytoplasmic membrane protein ES963_14990 ENOG4105CA9 Pyruvate kinase ES963_14995 ENOG4105CTQ phosphohexokinase ES963_15005 ENOG4108IEY Carboxyl transferase domain ES963_15010 ENOG4105C6K Malic enzyme ES963_15015 ENOG4105C0B DNA polymerase III (alpha subunit) ES963_15020 ENOG4105VV2 ES963_15030 ENOG4106EVM ES963_15035 ENOG4105SFS phosphoesterase RecJ domain protein ES963_15050 ENOG4105E8R UPF0173 metal-dependent hydrolase ES963_15065 ENOG4105CH7 arginosuccinase ES963_15070 ENOG4105CDH Citrulline--aspartate ligase ES963_15075 ENOG4105EPU Molybdenum cofactor synthesis domain protein ES963_15080 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) ES963_15095 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) ES963_15100 ENOG4105KBJ sporulation protein ytfj ES963_15110 ENOG4105VK3 rdd domain containing protein ES963_15115 ENOG4105D07 Signal peptide peptidase, SppA ES963_15120 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) ES963_15125 ENOG4105EFZ amidohydrolase ES963_15130 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ES963_15165 ENOG4105U5Y Transcriptional regulator ES963_15175 ENOG4105BZU Histidine kinase ES963_15185 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) ES963_15190 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) ES963_15200 ENOG4105F1V Acetoin utilization protein ES963_15205 ENOG4105W87 Cbs domain ES963_15210 ENOG4105DGU Histone deacetylase ES963_15215 ENOG4105ER2 Ompa motb domain protein ES963_15220 ENOG4107R0U MotA TolQ exbB proton channel ES963_15225 ENOG4105ETE Transcriptional regulator (LacI family ES963_15230 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase ES963_15250 ENOG4105DFU Cell wall formation (By similarity) ES963_15260 ENOG4108VDD TRNA binding domain protein ES963_15280 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ ES963_15295 ENOG4105C6K Malic enzyme ES963_15300 ENOG4105C8F Beta-lactamase domain protein ES963_15305 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) ES963_15315 ENOG4108V15 phosphotransferase enzyme family ES963_15320 ENOG4108IUM Glycogen debranching enzyme ES963_15335 ENOG4107F58 2'-5' rna ligase ES963_15340 ENOG4105C6T cysteine synthase ES963_15345 ENOG4107QSE Dipeptidase ES963_15350 ENOG4105C7N Xanthine uracil vitamin C permease ES963_15365 ENOG4105YW5 deoR family transcriptional regulator ES963_15380 ENOG4105CBX hi0933 family ES963_15385 ENOG4105C94 Transporter ES963_15395 ENOG4105MU9 integral membrane protein ES963_15400 ENOG4105DDC Oxidoreductase domain protein ES963_15410 ENOG4105F5H Glycosyl Hydrolase Family 88 ES963_15420 ENOG41075H3 AraC family transcriptional regulator ES963_15430 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component ES963_15445 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) ES963_15455 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) ES963_15460 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ES963_15470 ENOG4105NTD Inherit from COG: Hydrolase ES963_15485 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component ES963_15490 ENOG4105I1K ABC transporter ES963_15500 ENOG41085GJ domain protein ES963_15505 ENOG4105C8T Leucyl-tRNA synthetase ES963_15515 ENOG4105BZU Histidine kinase ES963_15520 ENOG410605W Major Facilitator ES963_15525 ENOG4106UBQ ES963_15535 ENOG4105C19 ABC transporter ES963_15540 ENOG4105EWM Histidine kinase ES963_15550 ENOG4107R34 abc transporter permease protein ES963_15555 ENOG4105C19 ABC transporter ES963_15570 ENOG4105DVE abc transporter atp-binding protein ES963_15575 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family ES963_15590 ENOG4105N5T Radical SAM Protein ES963_15605 ENOG4105E8V Alpha Beta Hydrolase Fold protein ES963_15610 ENOG4108Z0R Transferase ES963_15615 ENOG4105C85 amino acid ES963_15620 ENOG4105CAQ asparagine synthetase ES963_15625 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP ES963_15630 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase ES963_15645 ENOG4105D2X ABC transporter substrate-binding protein ES963_15655 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component ES963_15670 ENOG4108RMU ferritin dps family protein ES963_15685 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) ES963_15690 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) ES963_15695 ENOG4108V2W Carbonate dehydratase ES963_15720 ENOG4105CC5 ABC transporter ES963_15725 ENOG4105CC5 ABC transporter ES963_15730 ENOG4105DIK (ABC) transporter ES963_15735 ENOG4105DSE periplasmic solute binding protein ES963_15740 ENOG4105DTQ mandelate racemase muconate lactonizing ES963_15745 ENOG4105CEY Amp-dependent synthetase and ligase ES963_15750 ENOG4108IPT Naphthoate synthase ES963_15755 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) ES963_15760 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) ES963_15765 ENOG4105E4F Isochorismate synthase ES963_15790 ENOG4108IAJ Nad-dependent epimerase dehydratase ES963_15795 ENOG4107SBE Glycosyl transferase (Group 1 ES963_15810 ENOG4107SBE Glycosyl transferase (Group 1 ES963_15815 ENOG4108KS4 Spore coat protein ES963_15830 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) ES963_15840 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) ES963_15970 ENOG4105N67 Proton-coupled thiamine transporter YuaJ ES963_15975 ENOG4105VRR gCN5-related N-acetyltransferase ES963_15980 ENOG4105DZ6 Band 7 protein ES963_15990 ENOG4106DF1 ES963_15995 ENOG4108VNY MOSC domain protein ES963_16000 ENOG4108JB8 alcohol dehydrogenase ES963_16005 ENOG4105C26 Dehydrogenase ES963_16010 ENOG4105TRT Transcriptional regulator ES963_16025 ENOG4105CZN Potassium uptake protein ES963_16030 ENOG4107I77 yiaA/B two helix domain ES963_16035 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj ES963_16065 ENOG4107QZI cell division protein FtsK ES963_16095 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase ES963_16135 ENOG4108FKH Transglycosylase SLT domain ES963_16180 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ES963_16270 ENOG4105XEZ This methylase recognizes the double-stranded sequence TCGA, causes specific methylation on A-4 on both strands and protects the DNA from cleavage by the ES963_16295 ENOG41069ER domain protein ES963_16300 ENOG41087GE Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity) ES963_16315 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ES963_16335 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) ES963_16490 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ES963_16500 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) ES963_16510 ENOG4105EE0 oxidoreductase ES963_16515 ENOG4105DKG l-rhamnose isomerase ES963_16520 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) ES963_16525 ENOG4105DET Rhamnulokinase ES963_16530 ENOG4105E98 transcriptional regulator DeoR family ES963_16545 ENOG4105C8Q Methyl-accepting chemotaxis ES963_16550 ENOG4105C8Q Methyl-accepting chemotaxis ES963_16555 ENOG4105C8Q Methyl-accepting chemotaxis ES963_16560 ENOG4105C8Q Methyl-accepting chemotaxis ES963_16575 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme ES963_16590 ENOG4105C37 (CBS) domain ES963_16605 ENOG4107PBV potassium channel ES963_16610 ENOG4107PBV potassium channel ES963_16625 ENOG4107QYV phosphohexose isomerase ES963_16635 ENOG4107QW4 alcohol dehydrogenase ES963_16640 ENOG4105WG9 Conserved Protein ES963_16650 ENOG4105CHM Aminotransferase ES963_16655 ENOG4108ZB6 transcriptional regulator AsnC family ES963_16660 ENOG4108MUZ hydrolase ES963_16670 ENOG4105C87 Aminotransferase class I and II ES963_16675 ENOG4108HGU Histidine kinase ES963_16680 ENOG4105Y38 Kinase-associated protein B ES963_16700 ENOG4105BZ4 penicillin-binding protein ES963_16705 ENOG4105KIR Thiol-disulfide oxidoreductase dcc ES963_16720 ENOG4108MRH transcriptional regulatory protein ES963_16725 ENOG4105DIH basic membrane ES963_16730 ENOG4108JQ9 ABC transporter ES963_16735 ENOG4105UIB (ABC) transporter ES963_16755 ENOG4105D65 subunit l ES963_16760 ENOG4105HC0 Na H antiporter ES963_16765 ENOG4108ZE9 Monovalent cation H antiporter subunit C ES963_16770 ENOG4108JPZ Monovalent cation H antiporter subunit D ES963_16775 ENOG4105SC1 monovalent cation H antiporter subunit E ES963_16785 ENOG4105KJM monovalent cation h antiporter subunit g ES963_16790 ENOG4105KA0 thioesterase Superfamily protein ES963_16800 ENOG4105BZU Histidine kinase ES963_16830 ENOG4105D58 Diguanylate phosphodiesterase ES963_16835 ENOG4105DAP Nicotinate phosphoribosyltransferase ES963_16860 ENOG4105C02 permease ES963_16880 ENOG410904N short-chain dehydrogenase reductase ES963_16920 ENOG4108K8K Transcriptional regulator ES963_16925 ENOG4105DCF alanine dehydrogenase ES963_16935 ENOG4105WQT MbtH domain protein ES963_16940 ENOG4105CEY Amp-dependent synthetase and ligase ES963_16945 ENOG4105WQI isochorismatase ES963_16950 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase ES963_16955 ENOG4105E4F Isochorismate synthase ES963_16960 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase ES963_16965 ENOG4105NIV Esterase ES963_16985 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) ES963_16995 ENOG41069ER domain protein ES963_17010 ENOG4105CEP NADH dehydrogenase ES963_17015 ENOG4105CAY ferredoxin--nadp reductase ES963_17035 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 ES963_17040 ENOG4108YX9 iron--sulfur cluster insertion protein erpA ES963_17055 ENOG4105ZKE UPF0349 protein ES963_17070 ENOG41083MR nifu domain-containing protein ES963_17075 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein ES963_17080 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) ES963_17085 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) ES963_17090 ENOG4105D6E homoserine dehydrogenase ES963_17100 ENOG4108W5N phosphatidylglycerophosphatase a ES963_17105 ENOG4105D4U had-superfamily hydrolase, subfamily iia ES963_17115 ENOG4105MMD transcriptional regulator ES963_17120 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) ES963_17125 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) ES963_17130 ENOG4105FAA peptidase M23 ES963_17135 ENOG4108YTE sporulation protein YunB ES963_17140 ENOG4105KZD Domain of unknown function (DUF1805) ES963_17145 ENOG4107R8B 5'-nucleotidase ES963_17155 ENOG4105I3N Conserved Protein ES963_17165 ENOG4105CD3 dihydroorotase ES963_17170 ENOG4105G9B Transcriptional regulator ES963_17185 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) ES963_17190 ENOG4105VT2 5-hydroxyisourate hydrolase ES963_17200 ENOG4107YV9 domain protein ES963_17205 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding ES963_17220 ENOG4105XRQ Xanthine dehydrogenase accessory factor ES963_17225 ENOG4105C5R Aminotransferase ES963_17240 ENOG4108K8S endonuclease I ES963_17245 ENOG4108IJ9 (ABC) transporter ES963_17250 ENOG4105FDP GntR family transcriptional regulator ES963_17255 ENOG4108KPW sugar kinase ES963_17260 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component ES963_17265 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component ES963_17270 ENOG4105XN3 extracellular solute-binding protein family 1 ES963_17275 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine ES963_17280 ENOG4105PKS Excinuclease abc c subunit domain protein ES963_17285 ENOG4107VFR oxidoreductase ES963_17300 ENOG41090KQ Glyoxalase Bleomycin resistance protein (Dioxygenase ES963_17305 ENOG4105NPE arsR family transcriptional regulator ES963_17310 ENOG4105DIW FeS assembly protein SUFB ES963_17315 ENOG4108UNV SUF system FeS assembly protein, NifU family ES963_17320 ENOG4105C9B Cysteine desulfurase ES963_17325 ENOG4105JRK feS assembly protein SufD ES963_17330 ENOG4105C3K feS assembly ATPase SufC ES963_17350 ENOG4105D01 (LipO)protein ES963_17355 ENOG4108UMI ABC transporter, permease ES963_17360 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) ES963_17385 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) ES963_17390 ENOG41080E8 Transcriptional regulator, Spx MgsR family ES963_17395 ENOG4105C1G acyl-Coa dehydrogenase ES963_17400 ENOG4105CHU acetyl-coa acetyltransferase ES963_17430 ENOG41067TZ transcriptional regulator, MarR family ES963_17435 ENOG4105C0R drug resistance transporter emrb qaca subfamily ES963_17440 ENOG4105MDS 4-oxalocrotonate tautomerase ES963_17450 ENOG4105EGI Transcriptional regulator ES963_17460 ENOG4105E0A ABC, transporter ES963_17525 ENOG4105HUF DNA protection during starvation protein ES963_17530 ENOG4105C0H protease ES963_17540 ENOG4105F3H Histidine kinase ES963_17550 ENOG41067SE Tetr family transcriptional regulator ES963_17555 ENOG4105C9Q fumarate hydratase class II ES963_17580 ENOG4105WH1 Two component transcriptional regulator luxr family ES963_17585 ENOG4105ENE Histidine kinase ES963_17600 ENOG41087YS Phage shock protein A ES963_17615 ENOG4108WBT adenosyltransferase ES963_17620 ENOG4105E0A ABC, transporter ES963_17625 ENOG4105EHG Permease protein ES963_17630 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) ES963_17635 ENOG4105EWI Short-chain dehydrogenase reductase Sdr ES963_17640 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein ES963_17650 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ES963_17660 ENOG4106DF4 Sigma-70, region 4 ES963_17670 ENOG4105F0F Oxalate decarboxylase ES963_17680 ENOG4107RBB ABC transporter, permease ES963_17685 ENOG4105C19 ABC transporter ES963_17690 ENOG4108WMK Efflux transporter RND family MFP subunit ES963_17695 ENOG4105E0A ABC, transporter ES963_17700 ENOG4105EHG Permease protein ES963_17705 ENOG4105DQ5 transport system permease protein ES963_17720 ENOG4105D5Q Arginine ornithine antiporter ES963_17735 ENOG4107K5X Membrane-bound metal-dependent hydrolase ES963_17740 ENOG4107QZ2 Sulfatase ES963_17745 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family ES963_17750 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein ES963_17755 ENOG4105E0C molybdate abc transporter ES963_17770 ENOG4105EEQ Na H antiporter ES963_17775 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) ES963_17780 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) ES963_17785 ENOG4105EEM helicase ES963_17795 ENOG4105EN6 Membrane ES963_17805 ENOG4107ZQN disulfide bond ES963_17810 ENOG4105C59 p-type ATPase ES963_17815 ENOG4105C59 p-type ATPase ES963_17820 ENOG410681U heavy metal transport detoxification protein ES963_17825 ENOG4105VPX protein, conserved in bacteria ES963_17830 ENOG4105D9R oxidoreductase ES963_17835 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) ES963_17840 ENOG4105ME7 Membrane ES963_17845 ENOG4105RXJ ES963_17850 ENOG4105KPY Small multidrug resistance protein ES963_17855 ENOG4105KBX Transcriptional regulator, TetR family ES963_17860 ENOG4105EWI Short-chain dehydrogenase reductase Sdr ES963_17870 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) ES963_17875 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) ES963_17885 ENOG4105XZU Preprotein translocase, subunit SecG ES963_17910 ENOG4105KVH Transcriptional regulator ES963_17915 ENOG4105C8Q Methyl-accepting chemotaxis ES963_17920 ENOG4105R40 Glycine betaine carnitine choline ES963_17925 ENOG4108HQR Glycine betaine ES963_17930 ENOG4105E90 ABC transporter ES963_17935 ENOG4108IJ8 ABC transporter ES963_17940 ENOG4107HG4 Transcriptional regulator ES963_17945 ENOG4105R40 Glycine betaine carnitine choline ES963_17950 ENOG4108HQR Glycine betaine ES963_17955 ENOG4105E90 ABC transporter ES963_17960 ENOG4108IJ8 ABC transporter ES963_17965 ENOG4107HG4 Transcriptional regulator ES963_17970 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein ES963_17975 ENOG4108QCI YvbH-like oligomerisation region ES963_17985 ENOG4105T65 Membrane-associated protein ES963_17990 ENOG4108W0I acetyltransferase ES963_17995 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) ES963_18000 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) ES963_18005 ENOG4105CP7 Triose-phosphate isomerase ES963_18010 ENOG4105BZA Phosphoglycerate kinase ES963_18015 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ES963_18030 ENOG4105CMD Transcriptional regulator, GntR family ES963_18035 ENOG4105DEN Luciferase family ES963_18045 ENOG4105GZI Transcriptional regulator ES963_18050 ENOG4107RT3 EamA-like transporter family ES963_18060 ENOG4105VRS hydrolase family 18 ES963_18065 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) ES963_18070 ENOG4107QR9 Iron-sulfur cluster binding protein ES963_18075 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) ES963_18085 ENOG4105BZU Histidine kinase ES963_18090 ENOG4105KCT ABC transporter ES963_18095 ENOG4108M15 ABC transporter ES963_18100 ENOG4107R6F Alpha Beta Hydrolase Fold protein ES963_18105 ENOG4108MJI response regulator ES963_18120 ENOG4105EG2 ABC transporter, permease ES963_18130 ENOG4107FKK extracellular solute-binding protein family 1 ES963_18140 ENOG4105JXH GntR family transcriptional regulator ES963_18145 ENOG4105DAA L-lactate ES963_18150 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ES963_18160 ENOG4108ZPC Polysaccharide pyruvyl transferase ES963_18165 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase ES963_18170 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family ES963_18175 ENOG4105D3Q Sugar transferase ES963_18185 ENOG4105K64 Glycosyl transferase, family 2 ES963_18195 ENOG4107QRS glycosyltransferase group 2 family protein ES963_18200 ENOG41068W6 Capsular polysaccharide biosynthesis protein ES963_18205 ENOG4108KMV Glycosyl transferase (Group 1 ES963_18210 ENOG4105K64 Glycosyl transferase, family 2 ES963_18215 ENOG4108PQP glycosyl transferase group 1 ES963_18225 ENOG4108QV3 biosynthesis protein ES963_18230 ENOG4105HTX biosynthesis protein ES963_18240 ENOG4105EBR Carboxylesterase ES963_18255 ENOG4105NI3 Protein of unknown function (DUF3237) ES963_18265 ENOG4105FQP Beta-lactamase ES963_18270 ENOG4105EDQ levansucrase EC 2.4.1.10 ES963_18275 ENOG4108HKT sucrose-6-phosphate hydrolase ES963_18280 ENOG4107QTZ amino acid ES963_18315 ENOG4105EC2 ftsk spoIIIe ES963_18335 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase ES963_18370 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj ES963_18530 ENOG4108I7H Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ES963_18535 ENOG4108J9Q DNA ligase ES963_18555 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ES963_18565 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) ES963_18570 ENOG4107URF beta-phospho-glucomutase ES963_18575 ENOG4105CG3 alpha amylase, catalytic region ES963_18590 ENOG4105EG2 ABC transporter, permease ES963_18595 ENOG4105D56 permease protein ES963_18600 ENOG4107FKK extracellular solute-binding protein family 1 ES963_18605 ENOG4108IUK alpha amylase, catalytic ES963_18610 ENOG4105FKQ transcriptional regulator ES963_18615 ENOG4108URH decarboxylase ES963_18620 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain ES963_18625 ENOG4105CHH sulfate transporter ES963_18630 ENOG4108V2W Carbonate dehydratase ES963_18635 ENOG4105C5I Dehydrogenase ES963_18645 ENOG4105C19 ABC transporter ES963_18650 ENOG4105EWM Histidine kinase ES963_18660 ENOG4107A6P ES963_18665 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase ES963_18670 ENOG4105KRI phosphocarrier protein (HPr ES963_18675 ENOG4105CIE May be required for sporulation (By similarity) ES963_18680 ENOG4105CHW UPF0052 protein ES963_18685 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) ES963_18690 ENOG4108Z4K mutator MutT protein ES963_18695 ENOG4105C3M thioredoxin reductase ES963_18710 ENOG4105BZ1 (ABC) transporter ES963_18720 ENOG4106FGC ES963_18730 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase ES963_18735 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) ES963_18740 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase ES963_18745 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) ES963_18750 ENOG4105ECC imidazole-glycerol-phosphate dehydratase ES963_18755 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) ES963_18760 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) ES963_18765 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) ES963_18775 ENOG4108E16 pectate lyase ES963_18780 ENOG4108S4C acetyltransferase ES963_18785 ENOG4107XGZ Hydrolase ES963_18790 ENOG4105HKU nucleoside recognition domain-containing protein ES963_18795 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) ES963_18800 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) ES963_18805 ENOG4105CE4 GlcNAc 6-P deacetylase ES963_18810 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) ES963_18815 ENOG4105FDP GntR family transcriptional regulator ES963_18820 ENOG41088CQ domain protein ES963_18830 ENOG4106A3M Cytochrome p-450 ES963_18835 ENOG410625E ES963_18850 ENOG41086DT Membrane protein of unknown function ES963_18855 ENOG41067S9 phage shock protein C, PspC ES963_18860 ENOG4108PY7 ES963_18875 ENOG4105I03 Flagellin ES963_18880 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) ES963_18885 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) ES963_18900 ENOG4105MKU Transcriptional regulator ES963_18920 ENOG4105CN1 protease ES963_18925 ENOG4105CRP Part of the ABC transporter FtsEX involved in ES963_18930 ENOG4105CAK Cell division ATP-binding protein ftsE ES963_18955 ENOG4105MS2 ribosomal subunit Interface protein ES963_18970 ENOG4105MQ3 flagellar protein FliS ES963_18975 ENOG4107RT6 flagellar hook-associated ES963_18980 ENOG41083S7 flagellar protein FlaG ES963_18985 ENOG4105I03 Flagellin ES963_18990 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) ES963_18995 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) ES963_19000 ENOG4105MKD ES963_19005 ENOG4105DTJ flagellar hook-associated protein ES963_19010 ENOG4105E1Q flagellar hook-associated protein ES963_19025 ENOG4105RU3 ES963_19030 ENOG41081UC Inherit from COG: Competence protein ES963_19050 ENOG4105WH1 Two component transcriptional regulator luxr family ES963_19055 ENOG4105BZU Histidine kinase ES963_19060 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein ES963_19065 ENOG4108KGH TRANSCRIPTIONal ES963_19100 ENOG4108RDQ ABC transporter ES963_19110 ENOG4105ESV Glycosyl transferase, family 4 ES963_19115 ENOG4107EF8 Glycosyl transferase (Group 1 ES963_19130 ENOG4105QZI O-Antigen Polymerase ES963_19140 ENOG4105C6Y Udp-glucose 6-dehydrogenase ES963_19145 ENOG4107RA4 Glycosyl transferase (Group 1 ES963_19150 ENOG4105PSV Polysaccharide Biosynthesis Protein ES963_19155 ENOG4105D3Q Sugar transferase ES963_19160 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase ES963_19165 ENOG4105JFG SpoIID LytB domain protein ES963_19180 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase ES963_19185 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase ES963_19195 ENOG4105EY8 ABC transporter ES963_19215 ENOG4107SJB teichoic acid biosynthesis ES963_19220 ENOG4107SJB teichoic acid biosynthesis ES963_19225 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase ES963_19235 ENOG4107RZX Teichoic acid biosynthesis protein ES963_19245 ENOG4105DG6 mannose-6-phosphate isomerase ES963_19260 ENOG4108NHD germination protein ES963_19265 ENOG4105C54 Major Facilitator superfamily ES963_19270 ENOG4108KGH TRANSCRIPTIONal ES963_19275 ENOG4105J7I hydrolase ES963_19280 ENOG4105K4H Nlp p60 protein ES963_19290 ENOG4105PNM synthesis protein ES963_19300 ENOG4105N98 Capsule biosynthesis protein capB ES963_19305 ENOG4105ETE Transcriptional regulator (LacI family ES963_19310 ENOG4108RVA ribokinase ES963_19315 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) ES963_19320 ENOG4105C2J ABC transporter ES963_19325 ENOG4105CNN ABC, transporter ES963_19330 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator ES963_19345 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein ES963_19350 ENOG4107FQX Alpha-acetolactate decarboxylase ES963_19360 ENOG4107RSM transcriptional regulator ES963_19375 ENOG4106UIA ES963_19390 ENOG4107XC4 flavin reductase domain protein, FMN-binding ES963_19400 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) ES963_19410 ENOG4105CAH Chromate ES963_19415 ENOG4105FGV Chromate ES963_19425 ENOG4108WS4 fmn reductase ES963_19430 ENOG4107V2S Transcriptional regulator ES963_19480 ENOG4108XI2 Domain of unknown function (DUF1963) ES963_19485 ENOG4105C6Y Udp-glucose 6-dehydrogenase ES963_19490 ENOG4108RB3 Capsular polysaccharide biosynthesis protein ES963_19495 ENOG4107YJ4 chain length determinant protein ES963_19500 ENOG4105HTX biosynthesis protein ES963_19510 ENOG4105KBK Zinc finger, swim domain protein ES963_19515 ENOG4105C0D helicase ES963_19520 ENOG410667J hydrolase ES963_19525 ENOG4105E98 transcriptional regulator DeoR family ES963_19530 ENOG4105Z8H single-stranded DNA-binding protein ES963_19560 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) ES963_19565 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) ES963_19575 ENOG4105CGA flagellar basal-body rod protein FlgG ES963_19585 ENOG4105DFF Rod shape-determining protein mreb ES963_19590 ENOG4105MT0 Sporulation transcriptional regulator spoiiid ES963_19600 ENOG4107MII Sugar-specific transcriptional regulator TrmB ES963_19605 ENOG4105CZM Major Facilitator ES963_19610 ENOG4108M26 parallel beta-helix repeat protein ES963_19615 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease ES963_19620 ENOG41080V3 Major Facilitator superfamily ES963_19625 ENOG4105D3W isochorismatase ES963_19630 ENOG4107P26 ES963_19635 ENOG4105BZU Histidine kinase ES963_19645 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase ES963_19655 ENOG4105FRN stage II sporulation protein ES963_19660 ENOG4107TCE N-acetyltransferase ES963_19680 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) ES963_19685 ENOG4107TXC Transcriptional regulator ES963_19690 ENOG4106BRK ES963_19695 ENOG4108RYK Nad-dependent epimerase dehydratase ES963_19700 ENOG4108Z40 Transcriptional regulator ES963_19705 ENOG4105CQM Urea amidohydrolase subunit alpha ES963_19710 ENOG4105KI2 Urea amidohydrolase subunit beta ES963_19715 ENOG4108YZ9 Urea amidohydrolase subunit gamma ES963_19750 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) ES963_19760 ENOG4108TF4 von Willebrand factor, type A ES963_19775 ENOG4105JFG SpoIID LytB domain protein ES963_19780 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) ES963_19790 ENOG4106778 Protein of unknown function (DUF1146) ES963_19800 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) ES963_19805 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) ES963_19810 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) ES963_19815 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) ES963_19835 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) ES963_19845 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) ES963_19850 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) ES963_19855 ENOG4108UIC UPF0340 protein ES963_19860 ENOG4108YZG isomerase ES963_19865 ENOG4107WAU Protein tyrosine phosphatase ES963_19870 ENOG410815N Probably functions as a manganese efflux pump (By similarity) ES963_19875 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ES963_19885 ENOG4108ZXQ stage ii sporulation protein r ES963_19900 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) ES963_19905 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) ES963_19910 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase ES963_19920 ENOG4107TT2 Auxin Efflux Carrier ES963_19925 ENOG4105C6K Malic enzyme ES963_19930 ENOG4107104 thymidine kinase ES963_19935 ENOG41082DI 50s ribosomal protein l31 ES963_19940 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) ES963_19950 ENOG4105CBT Fructose-1,6-bisphosphatase ES963_19955 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) ES963_19960 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway ES963_19965 ENOG4105D2N Aldolase ES963_19970 ENOG410812K response regulator receiver protein ES963_19980 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) ES963_19990 ENOG4105C1G acyl-Coa dehydrogenase ES963_19995 ENOG4105DF6 Fe-S oxidoreductase ES963_20005 ENOG4105E5J UV damage endonuclease ES963_20015 ENOG4105NAE bifunctional deaminase-reductase domain protein ES963_20020 ENOG4105BZ1 (ABC) transporter ES963_20025 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) ES963_20040 ENOG4105R3A Nitrate reductase ES963_20045 ENOG4108IUE nitrate reductase beta subunit ES963_20065 ENOG4107V6Q Cyclic nucleotide-binding domain ES963_20075 ENOG4105C75 arginyL-tRNA synthetase ES963_20080 ENOG410684U Domain of unknown function (DUF1934) ES963_20095 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E ES963_20145 ENOG4107JM4 Tetratricopeptide repeat ES963_20160 ENOG4108UIN ybak prolyl-trna synthetase associated region ES963_20165 ENOG4105CYW agmatinase ES963_20170 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) ES963_20175 ENOG4105BZ4 penicillin-binding protein ES963_20185 ENOG4108XFG YwhD family ES963_20190 ENOG4108Z4T Peptidase M50 ES963_20195 ENOG41069HH 4-oxalocrotonate tautomerase ES963_20200 ENOG41067TZ transcriptional regulator, MarR family ES963_20205 ENOG4105C22 threonyL-tRNA synthetase ES963_20215 ENOG4105C57 major facilitator superfamily ES963_20220 ENOG41062ES Transcriptional regulator ES963_20230 ENOG4105DCI Phosphohydrolase ES963_20240 ENOG4108VCI transcription factor, rsfa family ES963_20245 ENOG4108RNG Permease of the drug metabolite transporter ES963_20250 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) ES963_20255 ENOG4105DUM transcriptional regulator, lysR family ES963_20260 ENOG4108IJ2 phosphate acetyltransferase ES963_20275 ENOG4105CHM Aminotransferase ES963_20285 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase ES963_20290 ENOG4105CHR reductase ES963_20295 ENOG4106CHD Bacilysin biosynthesis protein bacB ES963_20300 ENOG41061WN bacilysin biosynthesis protein ES963_20305 ENOG4105FCW Major Facilitator superfamily ES963_20320 ENOG4105C26 Dehydrogenase ES963_20325 ENOG4105D82 Glutamate dehydrogenase ES963_20335 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase ES963_20340 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase ES963_20345 ENOG4105C1B dTDP-glucose 4-6-dehydratase ES963_20350 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) ES963_20355 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG ES963_20360 ENOG4107TY6 Acylneuraminate cytidylyltransferase ES963_20370 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD ES963_20375 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase ES963_20415 ENOG4105C26 Dehydrogenase ES963_20420 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) ES963_20425 ENOG4108RJ9 Glycosyl transferase, family 2 ES963_20430 ENOG4105DWF phosphomethylpyrimidine kinase ES963_20445 ENOG4105C5Y PTS System ES963_20450 ENOG4108QTI )-transporter ES963_20465 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin ES963_20470 ENOG4105DEN Luciferase family ES963_20475 ENOG4108DBC nitroreductase ES963_20495 ENOG41060D1 Quinol oxidase ES963_20500 ENOG4105CCU oxidase (Subunit III) ES963_20505 ENOG4105BZ9 Cytochrome C oxidase, subunit I ES963_20510 ENOG4105E2S oxidase) subunit II ES963_20515 ENOG4107BMA Transglycosylase associated protein ES963_20525 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) ES963_20530 ENOG4105WH5 Teichoic acid glycosylation protein ES963_20555 ENOG4107ZXU DSBA oxidoreductase ES963_20560 ENOG4105DBE peroxidase ES963_20565 ENOG410650H (LipO)protein ES963_20570 ENOG4107SJW iron permease, FTR1 ES963_20575 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) ES963_20585 ENOG4105CMU LysR family (Transcriptional regulator ES963_20590 ENOG4105VAW lrga family ES963_20595 ENOG41067MG lrgb family ES963_20600 ENOG4105D8G Major Facilitator superfamily ES963_20610 ENOG4105DR4 Methyltransferase ES963_20620 ENOG4108YV3 Protein of unknown function (DUF2711) ES963_20625 ENOG4105CK1 PTS System ES963_20630 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin ES963_20645 ENOG4105X1N Glycosyl transferase family 8 ES963_20655 ENOG4105GVJ transcriptional regulator ES963_20660 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) ES963_20665 ENOG4105IIU Aminopeptidase ES963_20680 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase ES963_20700 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) ES963_20705 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein ES963_20715 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD ES963_20720 ENOG4108VHC Short-chain dehydrogenase reductase Sdr ES963_20725 ENOG4105CM2 brancheD-chain amino acid aminotransferase ES963_20730 ENOG4105F8D glycoside hydrolase family 4 ES963_20735 ENOG4105VCP PTS System ES963_20740 ENOG4105CK1 PTS System ES963_20745 ENOG4105VZJ PTS System ES963_20750 ENOG4105EMD TRANSCRIPTIONal ES963_20760 ENOG4108VX5 3-methyladenine DNA glycosylase ES963_20765 ENOG4105CH6 catalase ES963_20780 ENOG4105DA5 (ABC) transporter ES963_20785 ENOG41069JR ES963_20805 ENOG4105ETS cytosine purines uracil thiamine allantoin ES963_20810 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) ES963_20815 ENOG4108JJ8 (ABC) transporter ES963_20820 ENOG4108JJ9 ABC, transporter ES963_20825 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ES963_20830 ENOG4105C4M (Ubiquinol oxidase) subunit I ES963_20835 ENOG4105D2K citrate carrier protein ES963_20850 ENOG4107BJW polysaccharide deacetylase ES963_20870 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) ES963_20880 ENOG4105CMR udp-glucose 4-epimerase ES963_20890 ENOG4105BZU Histidine kinase ES963_20895 ENOG4105WH1 Two component transcriptional regulator luxr family ES963_20900 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) ES963_20925 ENOG4105DTD Dehydrogenase ES963_20930 ENOG4108IIH CoA-transferase subunit B ES963_20935 ENOG4105D6N CoA-transferase, subunit a ES963_20940 ENOG4105CY2 Citrate transporter ES963_20945 ENOG4105DHI Methyltransferase ES963_20965 ENOG4105CH6 catalase ES963_20970 ENOG4105D4T Citrate transporter ES963_20975 ENOG4108RZ2 Glycoside hydrolase family 16 ES963_20980 ENOG4105CID antiterminator ES963_20990 ENOG4105DEU major facilitator superfamily ES963_20995 ENOG4105C1J atp-dependent rna helicase ES963_21000 ENOG4107TDE lipolytic protein G-D-S-L family ES963_21135 ENOG4107YZX Universal stress protein ES963_21140 ENOG4105CS2 ec 3.2.1.21 ES963_21145 ENOG4105C5Y PTS System ES963_21155 ENOG4107EV6 Inherit from COG: YD repeat protein ES963_21165 ENOG4107EV6 Inherit from COG: YD repeat protein ES963_21180 ENOG4106Z5D Glycoside Hydrolase Family 43 ES963_21195 ENOG4105C84 Histidine ammonia-lyase ES963_21200 ENOG4105CGP Urocanate hydratase ES963_21205 ENOG4105CI2 imidazolone-5-propionate hydrolase ES963_21210 ENOG4107W25 arginase agmatinase formiminoglutamase ES963_21220 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) ES963_21225 ENOG4105D9N nucleoside ES963_21235 ENOG4107RHR regulatoR ES963_21240 ENOG4108TM9 integral membrane protein ES963_21245 ENOG4105ENY Ethanolamine utilization protein eutH ES963_21250 ENOG4108PGP mmge prpd family protein ES963_21255 ENOG4105CH2 amidohydrolase ES963_21265 ENOG4108HW4 amino acid AbC transporter ES963_21270 ENOG4105EAB amino acid AbC transporter ES963_21275 ENOG4108XSB acetyltransferase, (GNAT) family ES963_21280 ENOG4105CPU Monooxygenase ES963_21285 ENOG4107QHE Choloylglycine hydrolase ES963_21290 ENOG410667J hydrolase ES963_21320 ENOG4108V5C ABC transporter ES963_21350 ENOG4105D2N Aldolase ES963_21355 ENOG4107TRN Xylose isomerase domain protein TIM barrel ES963_21360 ENOG4105F0H myo-inositol catabolism protein ES963_21365 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) ES963_21375 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) ES963_21380 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) ES963_21385 ENOG4105D7K pfkb domain protein ES963_21395 ENOG4105C26 Dehydrogenase ES963_21405 ENOG4105CPC Aldo Keto reductase ES963_21420 ENOG4107QNK )-transporter ES963_21425 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) ES963_21435 ENOG41061TZ Short-chain dehydrogenase reductase Sdr ES963_21440 ENOG4105ST3 Transcriptional regulator ES963_21445 ENOG4105C26 Dehydrogenase ES963_21450 ENOG41085PJ rdd domain containing protein ES963_21460 ENOG41085PJ rdd domain containing protein ES963_21475 ENOG4105J7D transcriptional regulator ES963_21480 ENOG4107JEE Short-chain dehydrogenase reductase Sdr ES963_21485 ENOG41061AU MarR family Transcriptional regulator ES963_21495 ENOG41067MG lrgb family ES963_21505 ENOG4105BZW Glycerate kinase ES963_21510 ENOG4105G3Z GntR family transcriptional regulator ES963_21515 ENOG4105CMG Carbohydrate kinase ES963_21520 ENOG4105C6Z Gluconate ES963_21525 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) ES963_21530 ENOG4105D3R alkyl hydroperoxide reductase ES963_21535 ENOG4108JU3 Alkyl hydroperoxide reductase ES963_21540 ENOG4105CS2 ec 3.2.1.21 ES963_21555 ENOG4108S3Y transcriptional regulator ES963_21560 ENOG4107QKA exodeoxyribonuclease V beta ES963_21565 ENOG4105D0M Protease HtpX homolog ES963_21585 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 ES963_21595 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) ES963_21610 ENOG4105E2A Dehydrogenase ES963_21630 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) ES963_21635 ENOG4105WQG acetyltransferase ES963_21640 ENOG410780I phosphoprotein phosphatase activity ES963_21650 ENOG41066UZ arginase EC 3.5.3.1 ES963_21655 ENOG4108IQI permease ES963_21660 ENOG4105C8Y Acetylornithine aminotransferase ES963_21685 ENOG41082BM Transcriptional regulator, arsr family ES963_21690 ENOG4108JUB Transcriptional regulator ES963_21705 ENOG4105C0H protease ES963_21710 ENOG4105Q2H domain protein ES963_21725 ENOG4105BZU Histidine kinase ES963_21730 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ES963_21755 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis ES963_21765 ENOG4105CDU Replicative dna helicase ES963_21785 ENOG4105DJ2 Major Facilitator Superfamily ES963_21790 ENOG4105EDW glycosyl transferase, family 39 ES963_21795 ENOG4105K9Q Binds to the 23S rRNA (By similarity) ES963_21800 ENOG4105BZR domain protein ES963_21805 ENOG4108XMW Membrane ES963_21820 ENOG4105KVH Transcriptional regulator ES963_21825 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase ES963_21840 ENOG41090E6 transcriptional regulator MERR family ES963_21850 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein ES963_21855 ENOG4105DDN Pentapeptide repeat-containing protein ES963_21860 ENOG4105D94 Major Facilitator Superfamily ES963_21865 ENOG4107RSM transcriptional regulator ES963_21870 ENOG41082BV acetyltransferase ES963_21875 ENOG41081I9 integral membrane protein ES963_21890 ENOG4108U05 Transcriptional regulator ES963_21895 ENOG41082BV acetyltransferase ES963_21905 ENOG4108U7W acetyltransferase ES963_21910 ENOG4105UNS Pfam:DUF419 ES963_21915 ENOG4105NAE bifunctional deaminase-reductase domain protein ES963_21920 ENOG4105C7Z Conserved Protein ES963_21925 ENOG4107FCW Abortive infection protein ES963_21935 ENOG4108UW5 maltose o-acetyltransferase ES963_21940 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase ES963_21950 ENOG4105CGK Exodeoxyribonuclease III ES963_21955 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) ES963_21960 ENOG4108UUM single-stranded DNA-binding protein ES963_21965 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) ES963_21970 ENOG4105C3G gtp-binding protein ES963_21975 ENOG4108J2R molybdopterin oxidoreductase ES963_21980 ENOG4105VDK protein, conserved in bacteria ES963_21990 ENOG4108ZDA Sporulation protein YyaC ES963_21995 ENOG4105FA0 parb-like partition protein ES963_22000 ENOG4107QJE Chromosome Partitioning Protein ES963_22015 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) ES963_22020 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) ES963_22025 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) ES963_22040 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)