locus-tag	class	description
ES963_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ES963_00010	COG0592	DNA-directed DNA polymerase activity
ES963_00015	COG2501	S4 domain
ES963_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ES963_00030	COG0187	DNA topoisomerase II activity
ES963_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ES963_00070	COG0516	GMP reductase activity
ES963_00070	COG0517	IMP dehydrogenase activity
ES963_00075	COG1686	Belongs to the peptidase S11 family
ES963_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ES963_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ES963_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ES963_00100	COG1428	Deoxynucleoside kinase
ES963_00105	COG1428	Deoxynucleoside kinase
ES963_00110	COG1388	LysM domain
ES963_00110	COG3858	chitin binding
ES963_00115	COG1335	isochorismatase
ES963_00120	COG0590	tRNA wobble adenosine to inosine editing
ES963_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ES963_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ES963_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ES963_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
ES963_00190	COG3853	Toxic anion resistance protein (TelA)
ES963_00195	COG1982	Orn Lys Arg decarboxylase major
ES963_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ES963_00205	COG3870	Protein conserved in bacteria
ES963_00210	COG1728	Protein conserved in bacteria
ES963_00215	COG0470	DNA polymerase III
ES963_00220	COG1774	PSP1 C-terminal conserved region
ES963_00225	COG4467	Involved in initiation control of chromosome replication
ES963_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ES963_00235	COG2827	Endonuclease containing a URI domain
ES963_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ES963_00245	COG2002	toxin-antitoxin pair type II binding
ES963_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES963_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES963_00255	COG0084	hydrolase, TatD family'
ES963_00260	COG3584	3D domain protein
ES963_00260	COG3583	domain protein
ES963_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ES963_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ES963_00280	COG4466	Protein conserved in bacteria
ES963_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ES963_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ES963_00300	COG0251	oxidation-reduction process
ES963_00305	COG2088	sporulation resulting in formation of a cellular spore
ES963_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ES963_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ES963_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ES963_00325	COG0193	aminoacyl-tRNA hydrolase activity
ES963_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ES963_00340	COG2002	toxin-antitoxin pair type II binding
ES963_00345	COG2244	polysaccharide biosynthetic process
ES963_00350	COG3956	TIGRFAM MazG family protein
ES963_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ES963_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ES963_00375	COG1098	S1 RNA binding domain
ES963_00390	COG2208	phosphoserine phosphatase activity
ES963_00395	COG2304	oxidoreductase activity
ES963_00400	COG0515	serine threonine protein kinase
ES963_00405	COG0037	tRNA processing
ES963_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ES963_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ES963_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ES963_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ES963_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES963_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ES963_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
ES963_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES963_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ES963_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ES963_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ES963_00470	COG1396	sequence-specific DNA binding
ES963_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ES963_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ES963_00560	COG4463	regulation of RNA biosynthetic process
ES963_00565	COG3880	PFAM UvrB UvrC protein
ES963_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
ES963_00575	COG0542	response to heat
ES963_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ES963_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ES963_00590	COG4956	integral membrane protein (PIN domain superfamily)
ES963_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ES963_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ES963_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ES963_00615	COG1045	serine acetyltransferase
ES963_00620	COG0215	cysteine-tRNA ligase activity
ES963_00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ES963_00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ES963_00635	COG3688	RNA-binding protein containing a PIN domain
ES963_00640	COG1595	DNA-templated transcription, initiation
ES963_00645	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ES963_00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ES963_00655	COG0250	Participates in transcription elongation, termination and antitermination
ES963_00660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ES963_00665	COG0081	regulation of translation
ES963_00670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ES963_00675	COG0222	ribosome binding
ES963_00680	COG2813	Specifically methylates the guanine in position
ES963_00685	COG0085	RNA polymerase activity
ES963_00690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ES963_00695	COG1358	cellular component organization or biogenesis
ES963_00700	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ES963_00705	COG0049	tRNA binding
ES963_00710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ES963_00715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ES963_00720	COG0596	Alpha beta hydrolase
ES963_00725	COG0051	transcription antitermination factor activity, RNA binding
ES963_00730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ES963_00735	COG0088	Forms part of the polypeptide exit tunnel
ES963_00740	COG0089	rRNA binding
ES963_00745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ES963_00750	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ES963_00755	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ES963_00760	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ES963_00765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ES963_00770	COG0255	Belongs to the universal ribosomal protein uL29 family
ES963_00775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ES963_00780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ES963_00790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ES963_00800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ES963_00805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ES963_00810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ES963_00815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ES963_00820	COG1841	ribosomal large subunit assembly
ES963_00825	COG0200	Binds to the 23S rRNA
ES963_00830	COG0201	protein transport
ES963_00835	COG0563	adenylate kinase activity
ES963_00840	COG0024	Methionine aminopeptidase
ES963_00845	COG2163	COG2163 Ribosomal protein L14E L6E L27E
ES963_00850	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ES963_00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ES963_00860	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ES963_00865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ES963_00870	COG0202	RNA polymerase activity
ES963_00875	COG0203	ribosomal protein L17
ES963_00880	COG1122	ATPase activity
ES963_00885	COG1122	ATPase activity
ES963_00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ES963_00895	COG0101	tRNA pseudouridine synthase activity
ES963_00900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ES963_00905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ES963_00910	COG2226	methyltransferase
ES963_00920	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES963_00925	COG0489	protein tyrosine kinase activity
ES963_00935	COG2194	sulfuric ester hydrolase activity
ES963_00940	COG0726	polysaccharide deacetylase
ES963_01025	COG0659	secondary active sulfate transmembrane transporter activity
ES963_01030	COG0385	Bile acid
ES963_01035	COG2819	hydrolase of the alpha beta superfamily
ES963_01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES963_01045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES963_01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES963_01055	COG2207	Transcriptional regulator
ES963_01055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES963_01060	COG3876	Protein conserved in bacteria
ES963_01065	COG1472	Belongs to the glycosyl hydrolase 3 family
ES963_01070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ES963_01075	COG1263	PTS System
ES963_01075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES963_01080	COG1737	Transcriptional regulator
ES963_01085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ES963_01090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES963_01095	COG1683	Conserved Protein
ES963_01125	COG1595	DNA-templated transcription, initiation
ES963_01130	COG5662	AntiSigma factor
ES963_01135	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ES963_01140	COG4856	YbbR-like protein
ES963_01145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ES963_01150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ES963_01160	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ES963_01165	COG2169	Transcriptional regulator
ES963_01170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ES963_01175	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ES963_01180	COG3002	Belongs to the UPF0753 family
ES963_01185	COG0288	reversible hydration of carbon dioxide
ES963_01195	COG5609	conserved protein (DUF2294)
ES963_01200	COG0640	Transcriptional regulator
ES963_01210	COG2814	Major facilitator Superfamily
ES963_01225	COG0596	Alpha beta hydrolase
ES963_01230	COG0745	RESPONSE REGULATOR receiver
ES963_01235	COG0642	Histidine kinase
ES963_01245	COG0515	serine threonine protein kinase
ES963_01260	COG1113	amino acid transport
ES963_01275	COG2602	Beta-lactamase
ES963_01280	COG2124	cytochrome p450
ES963_01290	COG0531	amino acid
ES963_01295	COG0584	glycerophosphoryl diester phosphodiesterase
ES963_01300	COG2271	Major facilitator Superfamily
ES963_01315	COG1846	Transcriptional regulator
ES963_01315	COG0456	acetyltransferase
ES963_01320	COG2271	Major facilitator Superfamily
ES963_01325	COG0697	spore germination
ES963_01330	COG1917	Cupin 2, conserved barrel domain protein
ES963_01330	COG2207	Transcriptional regulator
ES963_01355	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ES963_01360	COG3591	Belongs to the peptidase S1B family
ES963_01370	COG0596	Alpha beta hydrolase
ES963_01375	COG1183	phosphatidylcholine synthase activity
ES963_01380	COG0586	Pfam SNARE associated Golgi protein
ES963_01385	COG0688	phosphatidylethanolamine metabolic process
ES963_01395	COG2312	Erythromycin esterase
ES963_01400	COG2207	Transcriptional regulator
ES963_01410	COG1301	dicarboxylic acid transport
ES963_01415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES963_01415	COG2190	(PTS) system
ES963_01415	COG1263	PTS System
ES963_01420	COG0363	glucosamine-6-phosphate deaminase activity
ES963_01435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES963_01440	COG0833	amino acid
ES963_01445	COG2040	homocysteine
ES963_01455	COG1115	amino acid carrier protein
ES963_01460	COG2066	Belongs to the glutaminase family
ES963_01465	COG4191	Histidine kinase
ES963_01470	COG0784	Response regulator, receiver
ES963_01480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ES963_01485	COG1012	belongs to the aldehyde dehydrogenase family
ES963_01490	COG2271	Major facilitator Superfamily
ES963_01495	COG4948	Mandelate Racemase Muconate Lactonizing
ES963_01500	COG2186	Transcriptional regulator
ES963_01505	COG2721	sulfolactate sulfo-lyase activity
ES963_01510	COG3173	Aminoglycoside phosphotransferase
ES963_01525	COG0745	RESPONSE REGULATOR receiver
ES963_01530	COG2205	protein histidine kinase activity
ES963_01535	COG1131	(ABC) transporter
ES963_01555	COG3773	Cell wall hydrolase
ES963_01560	COG2304	oxidoreductase activity
ES963_01570	COG3540	Alkaline phosphatase
ES963_01575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ES963_01580	COG0805	protein transport
ES963_01585	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ES963_01590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ES963_01595	COG0477	Major facilitator Superfamily
ES963_01600	COG1309	transcriptional regulator
ES963_01605	COG0252	asparaginase activity
ES963_01615	COG1714	RDD family
ES963_01620	COG3012	SEC-C Motif Domain Protein
ES963_01620	COG1405	negative regulation of cell septum assembly
ES963_01625	COG3290	protein histidine kinase activity
ES963_01630	COG3279	Response regulator of the LytR AlgR family
ES963_01635	COG4555	ABC transporter
ES963_01640	COG1668	transmembrane transport
ES963_01645	COG0667	Aldo Keto reductase
ES963_01660	COG1595	DNA-templated transcription, initiation
ES963_01665	COG1595	DNA-templated transcription, initiation
ES963_01670	COG1876	peptidase activity
ES963_01675	COG0457	Tetratricopeptide repeat
ES963_01680	COG1028	Short-chain dehydrogenase reductase Sdr
ES963_01685	COG0366	Alpha amylase catalytic
ES963_01690	COG0803	Belongs to the bacterial solute-binding protein 9 family
ES963_01695	COG1121	(ABC) transporter
ES963_01700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES963_01705	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES963_01710	COG2310	stress, protein
ES963_01715	COG2310	stress, protein
ES963_01720	COG2310	stress, protein
ES963_01725	COG0861	Integral membrane protein TerC family
ES963_01735	COG3853	Toxic anion resistance protein (TelA)
ES963_01740	COG0477	Major facilitator Superfamily
ES963_01750	COG2814	Major facilitator Superfamily
ES963_01755	COG0640	Transcriptional regulator
ES963_01760	COG0517	IMP dehydrogenase activity
ES963_01760	COG4175	Glycine betaine
ES963_01765	COG4176	ABC-type proline glycine betaine transport system permease component
ES963_01770	COG2113	Glycine betaine
ES963_01775	COG1473	amidohydrolase
ES963_01780	COG1288	antiporter activity
ES963_01790	COG0366	Alpha amylase catalytic
ES963_01795	COG0039	L-malate dehydrogenase activity
ES963_01800	COG1620	l-lactate permease
ES963_01805	COG2814	Major facilitator Superfamily
ES963_01810	COG1846	Transcriptional regulator
ES963_01815	COG1280	lysine exporter protein (LysE YggA)
ES963_01820	COG3403	YqcI/YcgG family
ES963_01825	COG1113	amino acid transport
ES963_01830	COG3665	Urea carboxylase-associated protein
ES963_01835	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ES963_01840	COG1660	Displays ATPase and GTPase activities
ES963_01845	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ES963_01850	COG2226	methyltransferase
ES963_01855	COG0583	DNA-binding transcription factor activity
ES963_01860	COG3458	cephalosporin-C deacetylase activity
ES963_01865	COG3541	Predicted nucleotidyltransferase
ES963_01870	COG0506	proline dehydrogenase activity
ES963_01875	COG1012	belongs to the aldehyde dehydrogenase family
ES963_01880	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES963_01885	COG2508	Transcriptional regulator
ES963_01890	COG3689	TIGRFAM TIGR03943 family protein
ES963_01895	COG0701	Predicted permease
ES963_01900	COG2267	carboxylic ester hydrolase activity
ES963_01905	COG0492	ferredoxin-NADP+ reductase activity
ES963_01910	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ES963_01910	COG1587	Uroporphyrinogen-III synthase
ES963_01915	COG2146	nitrite reductase [NAD(P)H] activity
ES963_01920	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ES963_01925	COG0243	molybdopterin cofactor binding
ES963_01930	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ES963_01935	COG2223	nitrite transmembrane transporter activity
ES963_01940	COG1469	GTP cyclohydrolase I activity
ES963_01945	COG1376	ErfK ybiS ycfS ynhG family protein
ES963_01955	COG0523	cobalamin synthesis protein
ES963_01960	COG0765	amino acid transport
ES963_01965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES963_01975	COG1714	RDD family
ES963_01985	COG1846	Transcriptional regulator
ES963_01995	COG3842	ATPase activity
ES963_02000	COG2723	6-phospho-beta-galactosidase activity
ES963_02010	COG3209	COG3209 Rhs family protein
ES963_02015	COG3290	protein histidine kinase activity
ES963_02015	COG0840	transmembrane signaling receptor activity
ES963_02020	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ES963_02025	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ES963_02030	COG1733	regulation of RNA biosynthetic process
ES963_02035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES963_02040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES963_02045	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES963_02050	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
ES963_02055	COG2814	Major facilitator Superfamily
ES963_02065	COG0697	spore germination
ES963_02070	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES963_02080	COG2364	Membrane
ES963_02085	COG1126	abc transporter atp-binding protein
ES963_02090	COG0765	amino acid transport
ES963_02095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES963_02100	COG0583	DNA-binding transcription factor activity
ES963_02105	COG0163	prenyltransferase activity
ES963_02110	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ES963_02125	COG0596	Alpha beta hydrolase
ES963_02130	COG3104	oligopeptide transport
ES963_02135	COG5434	Belongs to the glycosyl hydrolase 28 family
ES963_02145	COG0697	spore germination
ES963_02155	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ES963_02160	COG1136	(ABC) transporter
ES963_02165	COG0577	efflux transmembrane transporter activity
ES963_02170	COG0745	RESPONSE REGULATOR receiver
ES963_02175	COG3850	Histidine kinase
ES963_02175	COG5002	protein histidine kinase activity
ES963_02180	COG0457	Tetratricopeptide repeat
ES963_02200	COG0527	aspartate kinase activity
ES963_02205	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES963_02210	COG4605	iron ion homeostasis
ES963_02215	COG4604	ABC transporter, ATP-binding protein
ES963_02220	COG4607	ABC-type enterochelin transport system periplasmic component
ES963_02230	COG2814	Major facilitator Superfamily
ES963_02235	COG1309	transcriptional regulator
ES963_02240	COG0778	Nitroreductase
ES963_02245	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ES963_02250	COG0640	Transcriptional regulator
ES963_02255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES963_02260	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ES963_02265	COG1012	belongs to the aldehyde dehydrogenase family
ES963_02270	COG4975	Glucose uptake
ES963_02275	COG1028	Short-chain dehydrogenase reductase Sdr
ES963_02280	COG4549	nuclear export factor GLE1
ES963_02285	COG2372	response to copper ion
ES963_02285	COG1276	copper resistance
ES963_02290	COG1349	DNA-binding transcription factor activity
ES963_02300	COG2213	PTS system mannitol-specific
ES963_02305	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES963_02310	COG0246	Mannitol dehydrogenase
ES963_02315	COG0473	3-isopropylmalate dehydrogenase activity
ES963_02320	COG0681	Belongs to the peptidase S26 family
ES963_02330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ES963_02340	COG0561	phosphatase activity
ES963_02345	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ES963_02350	COG1914	H( )-stimulated, divalent metal cation uptake system
ES963_02355	COG4336	lyase activity
ES963_02360	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ES963_02365	COG1984	allophanate hydrolase subunit 2
ES963_02370	COG1414	Transcriptional regulator
ES963_02375	COG2755	lipolytic protein G-D-S-L family
ES963_02385	COG2329	Antibiotic biosynthesis monooxygenase
ES963_02390	COG0768	penicillin binding
ES963_02395	COG4989	oxidoreductase activity
ES963_02400	COG3711	transcriptional antiterminator
ES963_02405	COG0318	PFAM AMP-dependent synthetase and ligase
ES963_02410	COG2226	methyltransferase
ES963_02415	COG1028	Short-chain dehydrogenase reductase Sdr
ES963_02420	COG1917	Cupin 2, conserved barrel domain protein
ES963_02425	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES963_02430	COG3871	stress protein (general stress protein 26)
ES963_02440	COG2814	Major facilitator Superfamily
ES963_02445	COG1522	sequence-specific DNA binding
ES963_02450	COG0551	DNA topoisomerase type I activity
ES963_02450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ES963_02455	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ES963_02460	COG3706	GGDEF domain
ES963_02465	COG5298	Protein conserved in bacteria
ES963_02470	COG1215	transferase activity, transferring glycosyl groups
ES963_02480	COG0531	amino acid
ES963_02485	COG0494	nUDIX hydrolase
ES963_02490	COG0028	Belongs to the TPP enzyme family
ES963_02520	COG1914	H( )-stimulated, divalent metal cation uptake system
ES963_02525	COG2261	transglycosylase associated protein
ES963_02530	COG4876	unkown
ES963_02535	COG2217	Heavy metal translocating P-type atpase
ES963_02540	COG3729	General stress protein
ES963_02545	COG0662	Cupin 2, conserved barrel domain protein
ES963_02550	COG2329	Antibiotic biosynthesis monooxygenase
ES963_02555	COG3546	catalase activity
ES963_02560	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ES963_02565	COG3290	protein histidine kinase activity
ES963_02570	COG4565	transcriptional regulatory protein
ES963_02575	COG1301	dicarboxylic acid transport
ES963_02580	COG0628	permease
ES963_02585	COG1131	(ABC) transporter
ES963_02590	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES963_02600	COG1960	acyl-CoA dehydrogenase activity
ES963_02615	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES963_02620	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES963_02625	COG1181	Belongs to the D-alanine--D-alanine ligase family
ES963_02630	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ES963_02640	COG0513	Belongs to the DEAD box helicase family
ES963_02645	COG3402	PFAM membrane-flanked domain
ES963_02650	COG3428	Bacterial PH domain
ES963_02655	COG0705	Rhomboid family
ES963_02660	COG0736	holo-[acyl-carrier-protein] synthase activity
ES963_02665	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ES963_02670	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ES963_02675	COG0864	Transcriptional regulator
ES963_02680	COG2337	Toxic component of a toxin-antitoxin (TA) module
ES963_02685	COG1366	Belongs to the anti-sigma-factor antagonist family
ES963_02690	COG1366	Belongs to the anti-sigma-factor antagonist family
ES963_02695	COG2172	sigma factor antagonist activity
ES963_02700	COG2208	phosphoserine phosphatase activity
ES963_02705	COG1366	Belongs to the anti-sigma-factor antagonist family
ES963_02710	COG2172	sigma factor antagonist activity
ES963_02715	COG1191	sigma factor activity
ES963_02720	COG2208	phosphoserine phosphatase activity
ES963_02725	COG2183	response to ionizing radiation
ES963_02735	COG3091	SprT-like family
ES963_02785	COG0583	DNA-binding transcription factor activity
ES963_02790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES963_02800	COG5444	nuclease activity
ES963_02810	COG1476	TRANSCRIPTIONal
ES963_02835	COG0693	protein deglycase activity
ES963_02840	COG1278	Cold shock
ES963_02845	COG1329	Transcriptional regulator
ES963_02855	COG0697	spore germination
ES963_02860	COG1917	Cupin 2, conserved barrel domain protein
ES963_02860	COG2207	Transcriptional regulator
ES963_02865	COG0697	spore germination
ES963_02870	COG2207	Transcriptional regulator
ES963_02870	COG3708	Transcriptional regulator
ES963_02875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES963_02890	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
ES963_02905	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES963_02910	COG1309	transcriptional regulator
ES963_02915	COG0697	spore germination
ES963_02920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES963_02925	COG2030	dehydratase
ES963_02930	COG3545	Serine hydrolase
ES963_02935	COG1733	regulation of RNA biosynthetic process
ES963_02940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES963_02945	COG1733	regulation of RNA biosynthetic process
ES963_02950	COG2249	NAD(P)H dehydrogenase (quinone) activity
ES963_02955	COG2814	Major facilitator Superfamily
ES963_02960	COG1309	transcriptional regulator
ES963_02965	COG0640	Transcriptional regulator
ES963_02970	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ES963_02980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES963_02985	COG0697	spore germination
ES963_02990	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES963_02995	COG0076	glutamate decarboxylase activity
ES963_03000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ES963_03005	COG0640	Transcriptional regulator
ES963_03010	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ES963_03025	COG4585	Histidine kinase
ES963_03030	COG2197	response regulator
ES963_03035	COG2409	Drug exporters of the RND superfamily
ES963_03040	COG1811	Na channel or pump
ES963_03045	COG4978	Transcriptional regulator
ES963_03045	COG0789	Transcriptional regulator
ES963_03050	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES963_03055	COG0778	Nitroreductase
ES963_03060	COG0346	lactoylglutathione lyase activity
ES963_03065	COG2259	Doxx family
ES963_03070	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES963_03085	COG2323	membrane
ES963_03090	COG2323	membrane
ES963_03095	COG0071	Belongs to the small heat shock protein (HSP20) family
ES963_03110	COG1309	transcriptional regulator
ES963_03120	COG0456	acetyltransferase
ES963_03130	COG1113	amino acid transport
ES963_03135	COG2318	DinB family
ES963_03140	COG1846	Transcriptional regulator
ES963_03145	COG2409	Drug exporters of the RND superfamily
ES963_03145	COG1033	growth of symbiont in host cell
ES963_03150	COG0778	Nitroreductase
ES963_03155	COG1846	Transcriptional regulator
ES963_03160	COG2814	Major facilitator Superfamily
ES963_03165	COG0730	response to heat
ES963_03170	COG1802	Transcriptional regulator
ES963_03175	COG1388	LysM domain
ES963_03175	COG3858	chitin binding
ES963_03180	COG1819	glycosyl
ES963_03190	COG1785	Belongs to the alkaline phosphatase family
ES963_03195	COG5646	InterPro IPR014922
ES963_03205	COG0454	-acetyltransferase
ES963_03210	COG1078	dGTPase activity
ES963_03215	COG1388	LysM domain
ES963_03220	COG2814	Major facilitator Superfamily
ES963_03225	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES963_03230	COG1447	Phosphotransferase system cellobiose-specific component IIA
ES963_03235	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES963_03240	COG2723	6-phospho-beta-galactosidase activity
ES963_03245	COG2188	Transcriptional regulator
ES963_03250	COG1940	carbohydrate kinase activity
ES963_03255	COG1482	cell wall glycoprotein biosynthetic process
ES963_03260	COG4124	Belongs to the glycosyl hydrolase 26 family
ES963_03305	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ES963_03310	COG0802	atpase or kinase
ES963_03315	COG1214	PFAM Peptidase M22, glycoprotease
ES963_03320	COG0456	acetyltransferase
ES963_03325	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ES963_03330	COG0488	(ABC) transporter
ES963_03335	COG0315	cyclic pyranopterin monophosphate synthase activity
ES963_03340	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ES963_03345	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ES963_03350	COG0805	protein transport
ES963_03365	COG1266	CAAX protease self-immunity
ES963_03370	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ES963_03375	COG0459	protein refolding
ES963_03385	COG1073	alpha beta
ES963_03390	COG0457	Tetratricopeptide repeat
ES963_03395	COG1063	alcohol dehydrogenase
ES963_03400	COG2211	Major facilitator Superfamily
ES963_03405	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES963_03415	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ES963_03420	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ES963_03425	COG4260	virion core protein, lumpy skin disease virus
ES963_03435	COG2814	Major facilitator Superfamily
ES963_03440	COG1063	alcohol dehydrogenase
ES963_03445	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ES963_03450	COG0823	Involved in the tonB-independent uptake of proteins
ES963_03465	COG2267	carboxylic ester hydrolase activity
ES963_03475	COG2132	Multicopper oxidase
ES963_03480	COG1113	amino acid transport
ES963_03490	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES963_03495	COG0714	Associated with various cellular activities
ES963_03500	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
ES963_03505	COG1305	Transglutaminase-like
ES963_03510	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ES963_03510	COG0519	Catalyzes the synthesis of GMP from XMP
ES963_03525	COG2252	PERMEase
ES963_03530	COG3064	Membrane
ES963_03540	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
ES963_03550	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ES963_03555	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ES963_03560	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ES963_03565	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ES963_03570	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ES963_03575	COG0047	phosphoribosylformylglycinamidine synthase activity
ES963_03580	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ES963_03585	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ES963_03590	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ES963_03595	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ES963_03600	COG0138	bifunctional purine biosynthesis protein purh
ES963_03605	COG0151	Belongs to the GarS family
ES963_03610	COG1522	sequence-specific DNA binding
ES963_03615	COG0531	amino acid
ES963_03625	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ES963_03630	COG1470	cell adhesion involved in biofilm formation
ES963_03635	COG4496	protein, YerC YecD
ES963_03645	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ES963_03650	COG0210	DNA helicase
ES963_03655	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ES963_03660	COG4851	CamS sex pheromone cAM373 precursor
ES963_03665	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES963_03670	COG1285	pathogenesis
ES963_03675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES963_03680	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ES963_03685	COG0154	amidase activity
ES963_03690	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ES963_03695	COG1309	transcriptional regulator
ES963_03700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ES963_03705	COG1597	lipid kinase activity
ES963_03710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ES963_03775	COG5444	nuclease activity
ES963_03785	COG3586	endonuclease activity
ES963_03795	COG0457	Tetratricopeptide repeat
ES963_03805	COG0217	transcriptional regulatory protein
ES963_03815	COG1309	transcriptional regulator
ES963_03820	COG3631	Ketosteroid isomerase-related protein
ES963_03825	COG0702	epimerase
ES963_03840	COG3546	catalase activity
ES963_03845	COG0454	-acetyltransferase
ES963_03855	COG5578	integral membrane protein
ES963_03860	COG2972	Histidine kinase
ES963_03865	COG4753	response regulator
ES963_03865	COG2207	Transcriptional regulator
ES963_03870	COG1653	transport
ES963_03875	COG1175	transmembrane transport
ES963_03880	COG0395	ABC-type sugar transport system, permease component
ES963_03885	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ES963_03890	COG2207	Transcriptional regulator
ES963_03895	COG2755	lipolytic protein G-D-S-L family
ES963_03905	COG5578	integral membrane protein
ES963_03910	COG3401	FG-GAP repeat protein
ES963_03915	COG3401	FG-GAP repeat protein
ES963_03920	COG2755	lipolytic protein G-D-S-L family
ES963_03925	COG1874	Beta-galactosidase
ES963_03940	COG4209	transmembrane transport
ES963_03945	COG0395	ABC-type sugar transport system, permease component
ES963_03955	COG2323	membrane
ES963_03960	COG2329	Antibiotic biosynthesis monooxygenase
ES963_03965	COG0346	lactoylglutathione lyase activity
ES963_03980	COG5583	Uncharacterized small protein (DUF2292)
ES963_03985	COG0670	Belongs to the BI1 family
ES963_03990	COG0697	spore germination
ES963_03995	COG1846	Transcriptional regulator
ES963_04000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ES963_04010	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ES963_04010	COG2124	cytochrome p450
ES963_04015	COG1368	sulfuric ester hydrolase activity
ES963_04020	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ES963_04025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES963_04035	COG1216	Glycosyl transferase, family 2
ES963_04040	COG1442	glycosyl transferase family 8
ES963_04045	COG2223	nitrite transmembrane transporter activity
ES963_04050	COG1011	Hydrolase
ES963_04055	COG0531	amino acid
ES963_04060	COG1012	belongs to the aldehyde dehydrogenase family
ES963_04065	COG0840	transmembrane signaling receptor activity
ES963_04070	COG0488	(ABC) transporter
ES963_04085	COG2814	Major facilitator Superfamily
ES963_04100	COG0488	(ABC) transporter
ES963_04105	COG0513	Belongs to the DEAD box helicase family
ES963_04110	COG0456	acetyltransferase
ES963_04115	COG2130	NADP-dependent
ES963_04120	COG1120	ATPase activity
ES963_04125	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES963_04130	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES963_04135	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ES963_04150	COG3866	Pectate lyase
ES963_04155	COG0471	metal ion transport
ES963_04160	COG3290	protein histidine kinase activity
ES963_04165	COG4565	transcriptional regulatory protein
ES963_04170	COG3181	Tripartite tricarboxylate transporter family receptor
ES963_04175	COG2851	Citrate transporter
ES963_04180	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES963_04185	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
ES963_04190	COG1254	Belongs to the acylphosphatase family
ES963_04195	COG2258	MOSC domain
ES963_04215	COG0024	Methionine aminopeptidase
ES963_04220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES963_04220	COG1263	PTS System
ES963_04240	COG1115	amino acid carrier protein
ES963_04245	COG0697	spore germination
ES963_04250	COG0697	spore germination
ES963_04255	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES963_04255	COG1263	PTS System
ES963_04260	COG0366	Alpha amylase catalytic
ES963_04265	COG2188	Transcriptional regulator
ES963_04270	COG0778	Nitroreductase
ES963_04275	COG0737	Belongs to the 5'-nucleotidase family
ES963_04280	COG0693	protein deglycase activity
ES963_04285	COG2814	Major facilitator Superfamily
ES963_04290	COG4840	Belongs to the UPF0435 family
ES963_04295	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ES963_04300	COG4980	gas vesicle protein
ES963_04310	COG0477	Major facilitator Superfamily
ES963_04315	COG0387	Pfam Sodium calcium exchanger
ES963_04325	COG0668	transmembrane transport
ES963_04330	COG0535	radical SAM domain protein
ES963_04340	COG0726	polysaccharide deacetylase
ES963_04345	COG2084	Dehydrogenase
ES963_04350	COG0598	Magnesium transport protein CorA
ES963_04355	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ES963_04360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ES963_04370	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ES963_04375	COG4637	Psort location Cytoplasmic, score
ES963_04385	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES963_04390	COG0022	dehydrogenase e1 component
ES963_04395	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES963_04400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES963_04405	COG3284	Transcriptional regulator
ES963_04415	COG1742	UPF0060 membrane protein
ES963_04440	COG4842	Belongs to the WXG100 family
ES963_04445	COG1486	melibiose metabolic process
ES963_04450	COG1737	Transcriptional regulator
ES963_04455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES963_04455	COG1263	PTS System
ES963_04460	COG5434	Belongs to the glycosyl hydrolase 28 family
ES963_04465	COG1132	(ABC) transporter
ES963_04470	COG1132	(ABC) transporter
ES963_04475	COG2259	Doxx family
ES963_04480	COG2514	catechol 2,3-dioxygenase activity
ES963_04485	COG4585	Histidine kinase
ES963_04490	COG2197	response regulator
ES963_04500	COG1131	(ABC) transporter
ES963_04505	COG1511	domain protein
ES963_04505	COG0842	Transport permease protein
ES963_04510	COG0842	Transport permease protein
ES963_04515	COG1695	Transcriptional regulator
ES963_04520	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ES963_04525	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
ES963_04530	COG1309	transcriptional regulator
ES963_04535	COG2814	Major facilitator Superfamily
ES963_04540	COG2318	DinB family
ES963_04545	COG2814	Major facilitator Superfamily
ES963_04550	COG1846	Transcriptional regulator
ES963_04555	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ES963_04555	COG0392	lysyltransferase activity
ES963_04560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES963_04565	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES963_04570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES963_04575	COG0384	phenazine biosynthesis protein PhzF
ES963_04580	COG0778	Nitroreductase
ES963_04595	COG1090	epimerase
ES963_04600	COG2137	regulation of response to DNA damage stimulus
ES963_04610	COG2814	Major facilitator Superfamily
ES963_04625	COG3103	Sh3 type 3 domain protein
ES963_04630	COG5658	integral membrane protein
ES963_04635	COG0596	Alpha beta hydrolase
ES963_04640	COG0463	Glycosyl transferase, family 2
ES963_04645	COG4485	Bacterial membrane protein, YfhO
ES963_04650	COG1988	membrane-bound metal-dependent
ES963_04655	COG1194	a g-specific adenine glycosylase
ES963_04665	COG1028	Short-chain dehydrogenase reductase Sdr
ES963_04680	COG3557	Belongs to the UPF0374 family
ES963_04685	COG1132	(ABC) transporter
ES963_04690	COG4129	membrane
ES963_04695	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ES963_04700	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ES963_04705	COG0735	belongs to the Fur family
ES963_04815	COG4326	sporulation control protein
ES963_04825	COG5577	PFAM Coat F domain
ES963_04830	COG3340	Belongs to the peptidase S51 family
ES963_04835	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ES963_04845	COG0753	catalase activity
ES963_04850	COG1116	anion transmembrane transporter activity
ES963_04855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ES963_04860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ES963_04865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES963_04875	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ES963_04885	COG1476	TRANSCRIPTIONal
ES963_04895	COG3382	B3 4 domain protein
ES963_04900	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ES963_04910	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ES963_04915	COG0789	Transcriptional regulator
ES963_04920	COG1664	Polymer-forming cytoskeletal
ES963_04925	COG1664	Polymer-forming cytoskeletal
ES963_04930	COG2766	serine protein kinase
ES963_04935	COG2718	Belongs to the UPF0229 family
ES963_04940	COG1846	Transcriptional regulator
ES963_04945	COG1566	PFAM secretion protein HlyD family protein
ES963_04950	COG2814	Major facilitator Superfamily
ES963_04955	COG0655	NAD(P)H dehydrogenase (quinone) activity
ES963_04975	COG1725	Transcriptional regulator
ES963_04980	COG1131	(ABC) transporter
ES963_04985	COG1131	(ABC) transporter
ES963_04990	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES963_04995	COG1278	Cold shock
ES963_05005	COG1464	Belongs to the NlpA lipoprotein family
ES963_05015	COG1823	symporter activity
ES963_05020	COG5444	nuclease activity
ES963_05045	COG0582	viral genome integration into host DNA
ES963_05050	COG2946	Replication initiation factor
ES963_05090	COG0433	COG0433 Predicted ATPase
ES963_05100	COG5644	endopeptidase inhibitor activity
ES963_05105	COG0741	lytic transglycosylase activity
ES963_05105	COG0791	NLP P60 protein
ES963_05135	COG0457	Tetratricopeptide repeat
ES963_05155	COG5577	PFAM Coat F domain
ES963_05160	COG1525	nuclease
ES963_05160	COG0737	Belongs to the 5'-nucleotidase family
ES963_05160	COG4085	toxin activity
ES963_05165	COG3764	Sortase (surface protein transpeptidase)
ES963_05170	COG0564	pseudouridine synthase activity
ES963_05180	COG0517	IMP dehydrogenase activity
ES963_05185	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ES963_05190	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ES963_05190	COG3153	acetyltransferase
ES963_05195	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES963_05200	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ES963_05205	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ES963_05210	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ES963_05215	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ES963_05220	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ES963_05225	COG4585	Histidine kinase
ES963_05225	COG2203	Gaf domain
ES963_05230	COG2197	response regulator
ES963_05235	COG0431	NADPH-dependent FMN reductase
ES963_05250	COG1388	LysM domain
ES963_05250	COG0791	NLP P60 protein
ES963_05255	COG1959	2 iron, 2 sulfur cluster binding
ES963_05260	COG0668	transmembrane transport
ES963_05265	COG2719	SpoVR family
ES963_05270	COG1785	Belongs to the alkaline phosphatase family
ES963_05275	COG1388	LysM domain
ES963_05275	COG0791	NLP P60 protein
ES963_05280	COG0583	DNA-binding transcription factor activity
ES963_05285	COG0372	Belongs to the citrate synthase family
ES963_05290	COG1028	Short-chain dehydrogenase reductase Sdr
ES963_05295	COG0531	amino acid
ES963_05300	COG0733	neurotransmitter:sodium symporter activity
ES963_05305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES963_05310	COG0456	acetyltransferase
ES963_05325	COG1595	DNA-templated transcription, initiation
ES963_05330	COG0667	Aldo Keto reductase
ES963_05335	COG0204	Acyl-transferase
ES963_05340	COG1253	flavin adenine dinucleotide binding
ES963_05345	COG0789	Transcriptional regulator
ES963_05350	COG0436	Aminotransferase
ES963_05355	COG1253	flavin adenine dinucleotide binding
ES963_05360	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ES963_05365	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ES963_05370	COG0584	glycerophosphoryl diester phosphodiesterase
ES963_05380	COG0668	transmembrane transport
ES963_05385	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ES963_05390	COG0726	polysaccharide deacetylase
ES963_05395	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES963_05400	COG1757	Na H antiporter
ES963_05405	COG0589	response to stress
ES963_05415	COG1132	(ABC) transporter
ES963_05420	COG1132	(ABC) transporter
ES963_05425	COG0702	epimerase
ES963_05445	COG0189	ligase activity
ES963_05450	COG0189	ligase activity
ES963_05455	COG4399	Belongs to the UPF0754 family
ES963_05460	COG3679	Belongs to the UPF0342 family
ES963_05465	COG4335	DNA alkylation repair
ES963_05470	COG0561	phosphatase activity
ES963_05475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ES963_05480	COG0475	glutathione-regulated potassium exporter activity
ES963_05485	COG0490	domain, Protein
ES963_05495	COG1024	Enoyl-CoA hydratase
ES963_05505	COG4152	abc transporter atp-binding protein
ES963_05510	COG1668	transmembrane transport
ES963_05515	COG0420	3'-5' exonuclease activity
ES963_05520	COG4717	serine-type aminopeptidase activity
ES963_05525	COG3481	metal-dependent phosphohydrolase, HD sub domain
ES963_05535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ES963_05565	COG1846	Transcriptional regulator
ES963_05570	COG4980	gas vesicle protein
ES963_05585	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ES963_05590	COG0537	adenosine 5'-monophosphoramidase activity
ES963_05595	COG1131	(ABC) transporter
ES963_05600	COG4473	ABC transporter
ES963_05610	COG1473	amidohydrolase
ES963_05615	COG3069	C4-dicarboxylate transmembrane transporter activity
ES963_05625	COG2329	Antibiotic biosynthesis monooxygenase
ES963_05630	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES963_05635	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ES963_05650	COG1309	transcriptional regulator
ES963_05655	COG1511	domain protein
ES963_05660	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES963_05665	COG4377	Putative membrane peptidase family (DUF2324)
ES963_05675	COG1363	Peptidase, m42
ES963_05680	COG4405	Protein conserved in bacteria
ES963_05685	COG1301	dicarboxylic acid transport
ES963_05695	COG1234	tRNA 3'-trailer cleavage
ES963_05700	COG0095	Lipoate-protein ligase
ES963_05705	COG0702	epimerase
ES963_05710	COG0318	PFAM AMP-dependent synthetase and ligase
ES963_05720	COG0501	Belongs to the peptidase M48B family
ES963_05730	COG0456	acetyltransferase
ES963_05735	COG0604	alcohol dehydrogenase
ES963_05740	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ES963_05745	COG0406	alpha-ribazole phosphatase activity
ES963_05750	COG0183	Belongs to the thiolase family
ES963_05755	COG0318	PFAM AMP-dependent synthetase and ligase
ES963_05760	COG1268	BioY protein
ES963_05765	COG0840	transmembrane signaling receptor activity
ES963_05770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ES963_05770	COG0723	plastoquinol--plastocyanin reductase activity
ES963_05775	COG1028	Short-chain dehydrogenase reductase Sdr
ES963_05785	COG4903	ComK protein
ES963_05790	COG1028	Short-chain dehydrogenase reductase Sdr
ES963_05800	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES963_05815	COG0398	Pfam SNARE associated Golgi protein
ES963_05820	COG0681	Belongs to the peptidase S26 family
ES963_05825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ES963_05830	COG1846	Transcriptional regulator
ES963_05840	COG0738	Major facilitator superfamily
ES963_05845	COG0673	inositol 2-dehydrogenase activity
ES963_05850	COG0561	phosphatase activity
ES963_05855	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES963_05860	COG1609	Transcriptional regulator
ES963_05865	COG3180	Ammonia monooxygenase
ES963_05870	COG0477	Major facilitator Superfamily
ES963_05870	COG2814	Major facilitator Superfamily
ES963_05875	COG4533	DNA binding
ES963_05885	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ES963_05890	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ES963_05895	COG1074	ATP-dependent DNA helicase activity
ES963_05900	COG0420	3'-5' exonuclease activity
ES963_05905	COG0419	ATPase involved in DNA repair
ES963_05910	COG1403	HNH endonuclease
ES963_05950	COG5337	Spore coat protein CotH
ES963_05955	COG0179	Fumarylacetoacetate (FAA) hydrolase
ES963_05965	COG1404	Belongs to the peptidase S8 family
ES963_05975	COG0367	asparagine synthase
ES963_05980	COG1562	ergosterol biosynthetic process
ES963_05985	COG0534	Mate efflux family protein
ES963_05990	COG1917	Cupin 2, conserved barrel domain protein
ES963_05990	COG2207	Transcriptional regulator
ES963_05995	COG1609	Transcriptional regulator
ES963_06000	COG0673	inositol 2-dehydrogenase activity
ES963_06005	COG2318	DinB family
ES963_06010	COG1279	arginine transmembrane transporter activity
ES963_06015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES963_06020	COG1357	PFAM Pentapeptide repeats (8 copies)
ES963_06025	COG2267	carboxylic ester hydrolase activity
ES963_06030	COG0529	Catalyzes the synthesis of activated sulfate
ES963_06035	COG2046	Belongs to the sulfate adenylyltransferase family
ES963_06040	COG0175	sulfate reduction
ES963_06045	COG2045	Belongs to the ComB family
ES963_06050	COG1809	phosphosulfolactate synthase activity
ES963_06055	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES963_06060	COG4948	Mandelate Racemase Muconate Lactonizing
ES963_06065	COG2814	Major facilitator Superfamily
ES963_06070	COG0454	-acetyltransferase
ES963_06075	COG2153	protein acetylation
ES963_06080	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ES963_06080	COG0646	methionine synthase
ES963_06085	COG1666	GTP binding
ES963_06090	COG2996	Protein conserved in bacteria
ES963_06110	COG1695	Transcriptional regulator
ES963_06125	COG3227	Zinc metalloprotease (Elastase)
ES963_06130	COG1307	EDD domain protein, DegV family
ES963_06135	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES963_06150	COG0561	phosphatase activity
ES963_06155	COG1073	alpha beta
ES963_06160	COG2151	metal-sulfur cluster biosynthetic enzyme
ES963_06170	COG0277	FAD linked oxidase domain protein
ES963_06180	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ES963_06195	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ES963_06200	COG0505	Belongs to the CarA family
ES963_06205	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ES963_06210	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ES963_06225	COG2267	carboxylic ester hydrolase activity
ES963_06235	COG1744	ABC transporter substrate-binding protein PnrA-like
ES963_06250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES963_06255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ES963_06260	COG5504	Zn-dependent protease
ES963_06265	COG0444	Belongs to the ABC transporter superfamily
ES963_06270	COG4608	Belongs to the ABC transporter superfamily
ES963_06280	COG0601	transmembrane transport
ES963_06285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES963_06295	COG0180	Tryptophanyl-tRNA synthetase
ES963_06300	COG4166	transmembrane transport
ES963_06305	COG0601	transmembrane transport
ES963_06310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES963_06315	COG0444	Belongs to the ABC transporter superfamily
ES963_06320	COG4608	Belongs to the ABC transporter superfamily
ES963_06325	COG2814	Major facilitator Superfamily
ES963_06330	COG0456	acetyltransferase
ES963_06335	COG1393	Belongs to the ArsC family
ES963_06340	COG0861	Integral membrane protein TerC family
ES963_06350	COG4862	establishment of competence for transformation
ES963_06360	COG4469	Competence protein
ES963_06365	COG1164	Oligoendopeptidase f
ES963_06385	COG2346	COG2346, Truncated hemoglobins
ES963_06390	COG0741	lytic transglycosylase activity
ES963_06395	COG4116	CYTH
ES963_06405	COG2357	RelA SpoT domain protein
ES963_06410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ES963_06415	COG0564	pseudouridine synthase activity
ES963_06420	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ES963_06425	COG0569	domain protein
ES963_06425	COG0475	glutathione-regulated potassium exporter activity
ES963_06430	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ES963_06435	COG0352	thiamine-phosphate diphosphorylase activity
ES963_06440	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ES963_06445	COG2104	thiamine diphosphate biosynthetic process
ES963_06450	COG2022	thiamine diphosphate biosynthetic process
ES963_06455	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ES963_06460	COG0351	phosphomethylpyrimidine kinase
ES963_06465	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ES963_06520	COG0210	DNA helicase
ES963_06530	COG2153	protein acetylation
ES963_06535	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ES963_06540	COG2382	esterase
ES963_06545	COG0626	cystathionine gamma-synthase activity
ES963_06550	COG0626	cystathionine gamma-synthase activity
ES963_06555	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES963_06560	COG5505	Protein of unknown function (DUF819)
ES963_06590	COG1396	sequence-specific DNA binding
ES963_06655	COG0457	Tetratricopeptide repeat
ES963_06660	COG5444	nuclease activity
ES963_06720	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ES963_06730	COG3711	transcriptional antiterminator
ES963_06730	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES963_06735	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES963_06735	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES963_06735	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES963_06740	COG1482	cell wall glycoprotein biosynthetic process
ES963_06750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES963_06760	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ES963_06780	COG0109	protoheme IX farnesyltransferase activity
ES963_06790	COG0726	polysaccharide deacetylase
ES963_06805	COG5504	Zn-dependent protease
ES963_06810	COG2205	protein histidine kinase activity
ES963_06820	COG3383	formate dehydrogenase (NAD+) activity
ES963_06825	COG2427	Protein of unknown function (DUF1641)
ES963_06835	COG1051	belongs to the nudix hydrolase family
ES963_06845	COG2124	cytochrome p450
ES963_06850	COG1819	glycosyl
ES963_06860	COG1587	Uroporphyrinogen-III synthase
ES963_06865	COG0390	transport system, permease component
ES963_06870	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES963_06875	COG0697	spore germination
ES963_06880	COG4297	protein containing double-stranded beta helix domain
ES963_06890	COG1252	NADH dehydrogenase
ES963_06895	COG1904	glucuronate isomerase
ES963_06900	COG2211	Major facilitator Superfamily
ES963_06905	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
ES963_06910	COG1063	alcohol dehydrogenase
ES963_06915	COG1312	Catalyzes the dehydration of D-mannonate
ES963_06920	COG1028	Short-chain dehydrogenase reductase Sdr
ES963_06925	COG2271	Major facilitator Superfamily
ES963_06930	COG1609	Transcriptional regulator
ES963_06935	COG0246	Mannitol dehydrogenase
ES963_06940	COG2721	sulfolactate sulfo-lyase activity
ES963_06945	COG0730	response to heat
ES963_06950	COG2318	DinB family
ES963_06955	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ES963_06960	COG0457	Tetratricopeptide repeat
ES963_06970	COG2350	Protein conserved in bacteria
ES963_06975	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES963_06975	COG1388	LysM domain
ES963_06975	COG3409	Peptidoglycan-binding domain 1 protein
ES963_06985	COG4195	phage-related replication protein
ES963_06990	COG3546	catalase activity
ES963_06995	COG2856	Zn peptidase
ES963_07000	COG1396	sequence-specific DNA binding
ES963_07010	COG1522	sequence-specific DNA binding
ES963_07015	COG1484	DNA-dependent DNA replication
ES963_07035	COG1595	DNA-templated transcription, initiation
ES963_07040	COG3728	DNA packaging
ES963_07040	COG5484	DNA packaging
ES963_07045	COG1783	phage Terminase large subunit
ES963_07050	COG5518	Phage portal protein
ES963_07055	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ES963_07060	COG4653	Phage capsid family
ES963_07110	COG5412	phage tail tape measure protein
ES963_07110	COG5412	phage tail tape measure protein
ES963_07110	COG3953	SLT domain
ES963_07110	COG5412	phage tail tape measure protein
ES963_07110	COG3953	SLT domain
ES963_07110	COG3953	SLT domain
ES963_07115	COG1652	LysM domain
ES963_07120	COG4193	domain, Protein
ES963_07130	COG3628	GPW Gp25 family protein
ES963_07135	COG3299	homolog of phage Mu protein gp47
ES963_07140	COG3778	Protein conserved in bacteria
ES963_07180	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES963_07180	COG3409	Peptidoglycan-binding domain 1 protein
ES963_07200	COG0306	phosphate transporter
ES963_07205	COG1392	Phosphate transport regulator
ES963_07210	COG0531	amino acid
ES963_07215	COG0346	lactoylglutathione lyase activity
ES963_07220	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ES963_07225	COG0463	Glycosyl transferase, family 2
ES963_07230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES963_07235	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES963_07240	COG2362	D-Aminopeptidase
ES963_07245	COG0601	transmembrane transport
ES963_07250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES963_07255	COG0444	Belongs to the ABC transporter superfamily
ES963_07260	COG4166	transmembrane transport
ES963_07265	COG1619	proteins homologs of microcin C7 resistance protein MccF
ES963_07270	COG4948	Mandelate Racemase Muconate Lactonizing
ES963_07275	COG0791	NLP P60 protein
ES963_07280	COG4608	Belongs to the ABC transporter superfamily
ES963_07285	COG2706	6-phosphogluconolactonase activity
ES963_07290	COG1834	amidinotransferase
ES963_07295	COG1607	acyl-coa hydrolase
ES963_07300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ES963_07300	COG1017	nitric oxide dioxygenase activity
ES963_07310	COG2323	membrane
ES963_07315	COG2318	DinB family
ES963_07320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES963_07325	COG2076	Multidrug Resistance protein
ES963_07330	COG2076	Multidrug Resistance protein
ES963_07335	COG0788	formyltetrahydrofolate deformylase activity
ES963_07340	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ES963_07345	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ES963_07350	COG1764	response to oxidative stress
ES963_07355	COG1846	Transcriptional regulator
ES963_07360	COG1764	response to oxidative stress
ES963_07370	COG0590	tRNA wobble adenosine to inosine editing
ES963_07375	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ES963_07380	COG1404	Belongs to the peptidase S8 family
ES963_07385	COG1366	Belongs to the anti-sigma-factor antagonist family
ES963_07390	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ES963_07395	COG1122	ATPase activity
ES963_07400	COG4721	ABC-type cobalt transport system, permease component
ES963_07410	COG0745	RESPONSE REGULATOR receiver
ES963_07415	COG5002	protein histidine kinase activity
ES963_07415	COG3850	Histidine kinase
ES963_07420	COG3212	peptidase
ES963_07425	COG3212	peptidase
ES963_07440	COG2239	Acts as a magnesium transporter
ES963_07445	COG0789	Transcriptional regulator
ES963_07460	COG1846	Transcriptional regulator
ES963_07465	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ES963_07470	COG0726	polysaccharide deacetylase
ES963_07475	COG1408	metallophosphoesterase
ES963_07485	COG0463	Glycosyl transferase, family 2
ES963_07490	COG3285	dna ligase
ES963_07490	COG1793	dna ligase
ES963_07495	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ES963_07500	COG3300	MHYT domain
ES963_07500	COG5001	Diguanylate cyclase
ES963_07505	COG0586	Pfam SNARE associated Golgi protein
ES963_07510	COG0861	Integral membrane protein TerC family
ES963_07515	COG1191	sigma factor activity
ES963_07535	COG0501	Belongs to the peptidase M48B family
ES963_07540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ES963_07555	COG3594	Acyltransferase
ES963_07560	COG5002	protein histidine kinase activity
ES963_07565	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ES963_07575	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ES963_07580	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
ES963_07585	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ES963_07590	COG0436	Aminotransferase
ES963_07595	COG1850	ribulose-bisphosphate carboxylase activity
ES963_07600	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ES963_07605	COG0235	Class ii aldolase
ES963_07610	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ES963_07615	COG3339	Conserved Protein
ES963_07630	COG3852	Histidine kinase
ES963_07635	COG1846	Transcriptional regulator
ES963_07640	COG1360	Flagellar Motor Protein
ES963_07645	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ES963_07650	COG0542	response to heat
ES963_07655	COG3949	Membrane
ES963_07660	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ES963_07665	COG0720	synthase
ES963_07670	COG0602	queuosine metabolic process
ES963_07675	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ES963_07680	COG1733	regulation of RNA biosynthetic process
ES963_07685	COG1028	Short-chain dehydrogenase reductase Sdr
ES963_07760	COG4873	Protein conserved in bacteria
ES963_07770	COG3773	Cell wall hydrolase
ES963_07775	COG2244	polysaccharide biosynthetic process
ES963_07780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES963_07785	COG2217	Heavy metal translocating P-type atpase
ES963_07795	COG0006	proline dipeptidase activity
ES963_07800	COG1609	Transcriptional regulator
ES963_07805	COG3711	transcriptional antiterminator
ES963_07810	COG1263	PTS System
ES963_07810	COG2190	(PTS) system
ES963_07810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES963_07815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES963_07820	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ES963_07830	COG1533	DNA photolyase activity
ES963_07835	COG0456	acetyltransferase
ES963_07840	COG0840	transmembrane signaling receptor activity
ES963_07845	COG2084	Dehydrogenase
ES963_07850	COG2340	Cysteine-rich secretory protein family
ES963_07855	COG0768	penicillin binding
ES963_07860	COG4191	Histidine kinase
ES963_07865	COG0436	Aminotransferase
ES963_07875	COG0835	chemotaxis
ES963_07875	COG0784	Response regulator, receiver
ES963_07885	COG2814	Major facilitator Superfamily
ES963_07890	COG1376	ErfK ybiS ycfS ynhG family protein
ES963_07895	COG1408	metallophosphoesterase
ES963_07900	COG1028	Short-chain dehydrogenase reductase Sdr
ES963_07905	COG2200	EAL domain
ES963_07910	COG4703	Protein of unknown function (DUF1797)
ES963_07915	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
ES963_07925	COG0517	IMP dehydrogenase activity
ES963_07930	COG0583	DNA-binding transcription factor activity
ES963_07935	COG0716	FMN binding
ES963_07945	COG0716	FMN binding
ES963_07950	COG2171	N-acyltransferase activity
ES963_07955	COG1473	amidohydrolase
ES963_07965	COG0668	transmembrane transport
ES963_07970	COG0450	alkyl hydroperoxide reductase
ES963_07975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES963_07990	COG0746	molybdenum cofactor guanylyltransferase activity
ES963_07995	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ES963_08000	COG0303	'Molybdopterin
ES963_08005	COG1763	Mo-molybdopterin cofactor biosynthetic process
ES963_08010	COG0314	molybdopterin synthase activity
ES963_08015	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ES963_08020	COG1132	(ABC) transporter
ES963_08025	COG1132	(ABC) transporter
ES963_08035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ES963_08040	COG1136	(ABC) transporter
ES963_08045	COG0577	efflux transmembrane transporter activity
ES963_08050	COG1349	DNA-binding transcription factor activity
ES963_08055	COG1105	Belongs to the carbohydrate kinase PfkB family
ES963_08060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES963_08060	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES963_08060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES963_08065	COG0681	Belongs to the peptidase S26 family
ES963_08075	COG0488	(ABC) transporter
ES963_08080	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ES963_08085	COG2309	aminopeptidase activity
ES963_08095	COG1077	Cell shape determining protein MreB Mrl
ES963_08100	COG2002	toxin-antitoxin pair type II binding
ES963_08105	COG3852	Histidine kinase
ES963_08110	COG2105	PFAM AIG2 family protein
ES963_08110	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
ES963_08115	COG0569	domain protein
ES963_08120	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ES963_08125	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ES963_08135	COG0561	phosphatase activity
ES963_08140	COG0242	peptide deformylase activity
ES963_08155	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES963_08160	COG0022	dehydrogenase e1 component
ES963_08165	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES963_08170	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES963_08175	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES963_08185	COG1982	Orn Lys Arg decarboxylase major
ES963_08190	COG4476	Belongs to the UPF0223 family
ES963_08195	COG4493	Belongs to the UPF0637 family
ES963_08205	COG0483	inositol monophosphate 1-phosphatase activity
ES963_08215	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ES963_08235	COG1595	DNA-templated transcription, initiation
ES963_08265	COG4896	Protein conserved in bacteria
ES963_08275	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ES963_08280	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ES963_08285	COG2066	Belongs to the glutaminase family
ES963_08290	COG4838	Belongs to the UPF0358 family
ES963_08295	COG0772	Belongs to the SEDS family
ES963_08300	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ES963_08305	COG1612	heme a metabolic process
ES963_08310	COG0109	protoheme IX farnesyltransferase activity
ES963_08315	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ES963_08315	COG2010	Cytochrome c
ES963_08320	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ES963_08325	COG1845	cytochrome c oxidase, subunit III
ES963_08330	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ES963_08335	COG3336	cytochrome c oxidase
ES963_08345	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ES963_08350	COG2340	Cysteine-rich secretory protein family
ES963_08365	COG3679	Belongs to the UPF0342 family
ES963_08370	COG4471	UPF0298 protein
ES963_08375	COG0742	ribosomal rna small subunit methyltransferase
ES963_08380	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ES963_08385	COG3314	Sporulation integral membrane protein YlbJ
ES963_08390	COG1752	Esterase of the alpha-beta hydrolase superfamily
ES963_08395	COG3480	Lon protease (S16) C-terminal proteolytic domain
ES963_08400	COG1323	Belongs to the UPF0348 family
ES963_08410	COG1399	metal-binding, possibly nucleic acid-binding protein
ES963_08415	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ES963_08425	COG0454	-acetyltransferase
ES963_08430	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ES963_08435	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ES963_08440	COG2001	Belongs to the MraZ family
ES963_08445	COG0275	rRNA processing
ES963_08450	COG4839	cell division protein FtsL
ES963_08460	COG0768	penicillin binding
ES963_08465	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ES963_08470	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ES963_08475	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ES963_08480	COG0772	Belongs to the SEDS family
ES963_08485	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ES963_08490	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ES963_08495	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ES963_08500	COG3879	Bacterial protein of unknown function (DUF881)
ES963_08505	COG3879	Bacterial protein of unknown function (DUF881)
ES963_08510	COG3856	small basic protein
ES963_08515	COG0849	cell division
ES963_08520	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ES963_08525	COG1404	Belongs to the peptidase S8 family
ES963_08525	COG4412	M6 family metalloprotease domain protein
ES963_08535	COG1191	sigma factor activity
ES963_08540	COG1191	sigma factor activity
ES963_08545	COG1119	ATPase activity
ES963_08555	COG1873	PFAM PRC-barrel domain
ES963_08565	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ES963_08570	COG1799	cell septum assembly
ES963_08575	COG0762	integral membrane protein
ES963_08580	COG2302	S4 RNA-binding domain
ES963_08585	COG3599	regulation of cell shape
ES963_08590	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ES963_08595	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES963_08600	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ES963_08605	COG0564	pseudouridine synthase activity
ES963_08610	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ES963_08615	COG2233	PERMEase
ES963_08620	COG0540	Belongs to the ATCase OTCase family
ES963_08625	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ES963_08630	COG0505	Belongs to the CarA family
ES963_08635	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ES963_08640	COG0543	2 iron, 2 sulfur cluster binding
ES963_08645	COG0167	dihydroorotate dehydrogenase activity
ES963_08650	COG0284	orotidine-5'-phosphate decarboxylase activity
ES963_08655	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ES963_08660	COG0175	sulfate reduction
ES963_08665	COG0306	phosphate transporter
ES963_08670	COG2046	Belongs to the sulfate adenylyltransferase family
ES963_08675	COG0529	Catalyzes the synthesis of activated sulfate
ES963_08680	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ES963_08685	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
ES963_08690	COG1648	precorrin-2 dehydrogenase activity
ES963_08700	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ES963_08705	COG1561	YicC-like family, N-terminal region
ES963_08710	COG2052	Domain of unknown function (DUF370)
ES963_08715	COG0194	GDP metabolic process
ES963_08720	COG1758	RNA polymerase activity
ES963_08725	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ES963_08730	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ES963_08735	COG0242	peptide deformylase activity
ES963_08740	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ES963_08745	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ES963_08745	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ES963_08750	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ES963_08755	COG0631	protein serine/threonine phosphatase activity
ES963_08760	COG0515	serine threonine protein kinase
ES963_08760	COG2815	serine threonine protein kinase
ES963_08765	COG1162	GTPase activity
ES963_08770	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ES963_08775	COG1564	THIamine pyrophosphokinase
ES963_08785	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ES963_08790	COG1302	Protein conserved in bacteria
ES963_08795	COG1461	Dihydroxyacetone kinase
ES963_08800	COG1760	l-serine dehydratase
ES963_08805	COG1760	l-serine dehydratase
ES963_08810	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ES963_08815	COG2050	protein possibly involved in aromatic compounds catabolism
ES963_08815	COG1349	DNA-binding transcription factor activity
ES963_08820	COG0416	fatty acid biosynthetic process
ES963_08825	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ES963_08830	COG1028	Short-chain dehydrogenase reductase Sdr
ES963_08835	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES963_08840	COG0571	ribonuclease III activity
ES963_08845	COG1196	nuclear chromosome segregation
ES963_08850	COG0552	protein localization to endoplasmic reticulum
ES963_08860	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ES963_08865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ES963_08870	COG0228	four-way junction DNA binding
ES963_08875	COG1837	Belongs to the UPF0109 family
ES963_08885	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ES963_08890	COG0336	Belongs to the RNA methyltransferase TrmD family
ES963_08895	COG0335	large ribosomal subunit rRNA binding
ES963_08900	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ES963_08905	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ES963_08915	COG2257	FlhB HrpN YscU SpaS Family
ES963_08920	COG0045	succinate-CoA ligase (ADP-forming) activity
ES963_08925	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ES963_08930	COG0758	DNA mediated transformation
ES963_08935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ES963_08940	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ES963_08945	COG4974	Belongs to the 'phage' integrase family
ES963_08950	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ES963_08955	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ES963_08960	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ES963_08965	COG1815	bacterial-type flagellum-dependent cell motility
ES963_08970	COG1558	bacterial-type flagellum-dependent cell motility
ES963_08975	COG1677	Flagellar hook-basal body complex protein FliE
ES963_08980	COG1766	The M ring may be actively involved in energy transduction
ES963_08985	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES963_08990	COG1317	bacterial-type flagellum organization
ES963_08995	COG1157	protein secretion by the type III secretion system
ES963_09000	COG2882	bacterial-type flagellum organization
ES963_09005	COG3334	PFAM MgtE intracellular
ES963_09010	COG3144	bacterial-type flagellum assembly
ES963_09015	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ES963_09020	COG4786	Flagellar basal body rod
ES963_09025	COG1582	Flagellar protein (FlbD)
ES963_09030	COG1580	Controls the rotational direction of flagella during chemotaxis
ES963_09035	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES963_09040	COG1776	CheC inhibitor of MCP methylation
ES963_09040	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES963_09045	COG2201	protein-glutamate methylesterase activity
ES963_09050	COG3190	flagellar
ES963_09055	COG1338	Plays a role in the flagellum-specific transport system
ES963_09060	COG1987	bacterial-type flagellum assembly
ES963_09065	COG1684	flagellar biosynthetic protein fliR
ES963_09070	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ES963_09075	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ES963_09080	COG1419	protein localization to endoplasmic reticulum
ES963_09085	COG0455	bacterial-type flagellum organization
ES963_09090	COG2201	protein-glutamate methylesterase activity
ES963_09095	COG0643	Histidine kinase
ES963_09095	COG2198	Histidine kinase
ES963_09100	COG0835	chemotaxis
ES963_09105	COG1776	CheC inhibitor of MCP methylation
ES963_09110	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ES963_09115	COG1191	sigma factor activity
ES963_09125	COG0052	Belongs to the universal ribosomal protein uS2 family
ES963_09130	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ES963_09135	COG0528	UMP kinase activity
ES963_09140	COG0233	cytoplasmic translational termination
ES963_09145	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ES963_09150	COG4589	Belongs to the CDS family
ES963_09155	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ES963_09160	COG0750	zinc metalloprotease
ES963_09165	COG0442	prolyl-tRNA aminoacylation
ES963_09170	COG2176	DNA-directed DNA polymerase activity
ES963_09175	COG0779	Required for maturation of 30S ribosomal subunits
ES963_09180	COG0195	Participates in both transcription termination and antitermination
ES963_09185	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ES963_09190	COG1358	cellular component organization or biogenesis
ES963_09195	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ES963_09200	COG1550	Protein conserved in bacteria
ES963_09205	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ES963_09210	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ES963_09215	COG0196	riboflavin kinase activity
ES963_09220	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ES963_09225	COG1185	polyribonucleotide nucleotidyltransferase activity
ES963_09230	COG0726	polysaccharide deacetylase
ES963_09235	COG0612	Peptidase, M16
ES963_09240	COG1873	PFAM PRC-barrel domain
ES963_09245	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ES963_09250	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ES963_09255	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ES963_09260	COG0527	aspartate kinase activity
ES963_09265	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ES963_09270	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ES963_09275	COG0740	serine-type endopeptidase activity
ES963_09285	COG4980	gas vesicle protein
ES963_09285	COG1674	ftsk spoiiie
ES963_09290	COG2188	Transcriptional regulator
ES963_09295	COG2814	Major facilitator Superfamily
ES963_09300	COG0612	Peptidase, M16
ES963_09305	COG0612	Peptidase, M16
ES963_09310	COG0300	oxidoreductase activity
ES963_09325	COG1426	Protein conserved in bacteria
ES963_09330	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ES963_09335	COG1546	Belongs to the CinA family
ES963_09335	COG1058	Belongs to the CinA family
ES963_09340	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ES963_09345	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ES963_09350	COG1418	mRNA catabolic process
ES963_09355	COG1692	metallophosphoesterase
ES963_09360	COG2359	stage V sporulation protein S
ES963_09365	COG1063	alcohol dehydrogenase
ES963_09370	COG0156	8-amino-7-oxononanoate synthase activity
ES963_09375	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ES963_09380	COG4550	Control of competence regulator ComK, YlbF/YmcA
ES963_09390	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ES963_09395	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ES963_09475	COG3226	Transcriptional regulator
ES963_09485	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES963_09490	COG1404	Belongs to the peptidase S8 family
ES963_09495	COG4195	phage-related replication protein
ES963_09500	COG1764	response to oxidative stress
ES963_09505	COG2076	Multidrug Resistance protein
ES963_09510	COG2076	Multidrug Resistance protein
ES963_09525	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ES963_09530	COG1923	regulation of RNA biosynthetic process
ES963_09545	COG1780	Probably involved in ribonucleotide reductase function
ES963_09550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES963_09555	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES963_09560	COG4112	unkown
ES963_09565	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES963_09575	COG0464	growth
ES963_09580	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ES963_09585	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ES963_09590	COG0789	Transcriptional regulator
ES963_09595	COG0174	glutamine synthetase
ES963_09600	COG4974	Belongs to the 'phage' integrase family
ES963_09620	COG3645	SOS response
ES963_09620	COG3646	Phage regulatory protein
ES963_09800	COG5280	Phage tail tape measure protein TP901
ES963_09800	COG3953	SLT domain
ES963_09810	COG1705	Flagellar rod assembly protein muramidase FlgJ
ES963_09835	COG4824	toxin secretion phage lysis holin
ES963_09840	COG3409	Peptidoglycan-binding domain 1 protein
ES963_09840	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES963_09850	COG5444	nuclease activity
ES963_09855	COG0457	Tetratricopeptide repeat
ES963_09885	COG4282	regulation of fungal-type cell wall biogenesis
ES963_09900	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES963_09915	COG3655	Transcriptional regulator
ES963_09940	COG0135	phosphoribosylanthranilate isomerase activity
ES963_09945	COG2211	Major facilitator Superfamily
ES963_09950	COG3507	Belongs to the glycosyl hydrolase 43 family
ES963_09955	COG1940	carbohydrate kinase activity
ES963_09960	COG2115	Belongs to the xylose isomerase family
ES963_09965	COG1070	Carbohydrate kinase
ES963_09975	COG1525	nuclease
ES963_09980	COG2814	Major facilitator Superfamily
ES963_09985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ES963_09995	COG0756	dUTP diphosphatase activity
ES963_10035	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ES963_10045	COG3832	glyoxalase III activity
ES963_10090	COG4195	phage-related replication protein
ES963_10100	COG0346	lactoylglutathione lyase activity
ES963_10110	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ES963_10115	COG1388	LysM domain
ES963_10120	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ES963_10125	COG4224	UPF0291 protein
ES963_10130	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ES963_10140	COG3763	UPF0154 protein
ES963_10150	COG0785	Cytochrome C biogenesis protein
ES963_10155	COG2201	protein-glutamate methylesterase activity
ES963_10160	COG4846	Membrane protein involved in cytochrome C biogenesis
ES963_10170	COG0071	Belongs to the small heat shock protein (HSP20) family
ES963_10185	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ES963_10190	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES963_10210	COG0824	Thioesterase
ES963_10220	COG4841	protein insertion into membrane
ES963_10225	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ES963_10230	COG1832	CoA-binding protein
ES963_10235	COG0187	DNA topoisomerase II activity
ES963_10240	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ES963_10250	COG1115	amino acid carrier protein
ES963_10255	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ES963_10265	COG5520	Belongs to the glycosyl hydrolase 30 family
ES963_10275	COG2246	polysaccharide biosynthetic process
ES963_10285	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ES963_10290	COG0586	Pfam SNARE associated Golgi protein
ES963_10295	COG2404	hydrolase activity, acting on ester bonds
ES963_10300	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ES963_10305	COG1024	Enoyl-CoA hydratase
ES963_10310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ES963_10315	COG0511	ligase activity, forming carbon-carbon bonds
ES963_10320	COG0439	Biotin carboxylase
ES963_10325	COG0318	PFAM AMP-dependent synthetase and ligase
ES963_10330	COG1960	acyl-CoA dehydrogenase activity
ES963_10345	COG1649	PFAM Uncharacterised BCR, COG1649
ES963_10355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES963_10355	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
ES963_10360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES963_10365	COG2027	D-alanyl-D-alanine carboxypeptidase
ES963_10370	COG2017	converts alpha-aldose to the beta-anomer
ES963_10375	COG0534	Mate efflux family protein
ES963_10390	COG0582	viral genome integration into host DNA
ES963_10395	COG0166	Belongs to the GPI family
ES963_10400	COG0405	Gamma-glutamyltransferase
ES963_10405	COG0583	DNA-binding transcription factor activity
ES963_10410	COG0604	alcohol dehydrogenase
ES963_10415	COG0493	'glutamate synthase
ES963_10420	COG0070	glutamate synthase
ES963_10420	COG0069	glutamate synthase activity
ES963_10420	COG0067	glutamate synthase
ES963_10425	COG0583	DNA-binding transcription factor activity
ES963_10430	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ES963_10435	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES963_10445	COG0300	oxidoreductase activity
ES963_10450	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ES963_10460	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES963_10465	COG2814	Major facilitator Superfamily
ES963_10470	COG1070	Carbohydrate kinase
ES963_10475	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ES963_10480	COG0243	molybdopterin cofactor binding
ES963_10490	COG2814	Major facilitator Superfamily
ES963_10495	COG0673	inositol 2-dehydrogenase activity
ES963_10500	COG1082	Xylose isomerase domain protein TIM barrel
ES963_10505	COG1609	Transcriptional regulator
ES963_10525	COG0840	transmembrane signaling receptor activity
ES963_10525	COG5278	phosphoserine phosphatase activity
ES963_10530	COG2368	4-hydroxyphenylacetate
ES963_10540	COG3619	membrane
ES963_10545	COG3866	Pectate lyase
ES963_10550	COG2135	peptidase activity
ES963_10560	COG2140	Oxalate decarboxylase
ES963_10585	COG2720	vancomycin resistance protein
ES963_10600	COG3739	integral membrane protein
ES963_10605	COG0583	DNA-binding transcription factor activity
ES963_10610	COG0697	spore germination
ES963_10620	COG0693	protein deglycase activity
ES963_10625	COG2367	Beta-lactamase
ES963_10655	COG0726	polysaccharide deacetylase
ES963_10665	COG2314	TM2 domain
ES963_10780	COG0457	Tetratricopeptide repeat
ES963_10785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES963_10795	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ES963_10800	COG2226	methyltransferase
ES963_10805	COG2211	Major facilitator Superfamily
ES963_10855	COG5444	nuclease activity
ES963_10860	COG4282	regulation of fungal-type cell wall biogenesis
ES963_10865	COG1231	oxidoreductase activity
ES963_10870	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES963_10875	COG0662	Cupin 2, conserved barrel domain protein
ES963_10875	COG2207	Transcriptional regulator
ES963_10880	COG0456	acetyltransferase
ES963_10885	COG1309	transcriptional regulator
ES963_10890	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES963_10895	COG3708	Transcriptional regulator
ES963_10900	COG2378	regulation of single-species biofilm formation
ES963_10910	COG0640	Transcriptional regulator
ES963_10915	COG0741	lytic transglycosylase activity
ES963_10920	COG2322	membrane
ES963_10935	COG1619	proteins homologs of microcin C7 resistance protein MccF
ES963_10940	COG3239	Fatty acid desaturase
ES963_10945	COG4585	Histidine kinase
ES963_10950	COG2197	response regulator
ES963_10955	COG3584	3D domain protein
ES963_10955	COG1388	LysM domain
ES963_10960	COG0514	ATP-dependent DNA helicase (RecQ)
ES963_10975	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ES963_10980	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES963_10995	COG0071	Belongs to the small heat shock protein (HSP20) family
ES963_11020	COG1012	belongs to the aldehyde dehydrogenase family
ES963_11025	COG1657	PFAM Prenyltransferase squalene oxidase
ES963_11030	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ES963_11035	COG0733	neurotransmitter:sodium symporter activity
ES963_11040	COG0385	Bile acid
ES963_11045	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES963_11050	COG0567	Dehydrogenase, E1 component
ES963_11055	COG4548	von Willebrand factor, type A
ES963_11060	COG0714	Associated with various cellular activities
ES963_11065	COG2032	superoxide dismutase activity
ES963_11070	COG1388	LysM domain
ES963_11070	COG0791	NLP P60 protein
ES963_11075	COG1819	glycosyl
ES963_11080	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ES963_11085	COG0534	Mate efflux family protein
ES963_11090	COG1366	Belongs to the anti-sigma-factor antagonist family
ES963_11095	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES963_11100	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES963_11110	COG2962	Rard protein
ES963_11130	COG1942	4-Oxalocrotonate Tautomerase
ES963_11135	COG1733	regulation of RNA biosynthetic process
ES963_11140	COG0778	Nitroreductase
ES963_11145	COG0400	carboxylic ester hydrolase activity
ES963_11150	COG0346	lactoylglutathione lyase activity
ES963_11160	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES963_11165	COG0793	Belongs to the peptidase S41A family
ES963_11165	COG3409	Peptidoglycan-binding domain 1 protein
ES963_11170	COG2226	methyltransferase
ES963_11180	COG1876	peptidase activity
ES963_11185	COG0813	purine-nucleoside phosphorylase activity
ES963_11200	COG0671	phosphoesterase, PA-phosphatase related
ES963_11225	COG4479	Belongs to the UPF0346 family
ES963_11235	COG1509	lysine 2,3-aminomutase activity
ES963_11240	COG0456	acetyltransferase
ES963_11245	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES963_11250	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ES963_11255	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ES963_11260	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES963_11275	COG0456	acetyltransferase
ES963_11280	COG0463	Glycosyl transferase, family 2
ES963_11295	COG4641	Protein conserved in bacteria
ES963_11300	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
ES963_11305	COG1086	Polysaccharide biosynthesis protein
ES963_11310	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ES963_11315	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ES963_11320	COG1846	Transcriptional regulator
ES963_11325	COG0534	Mate efflux family protein
ES963_11335	COG4698	Protein conserved in bacteria
ES963_11340	COG2755	lipolytic protein G-D-S-L family
ES963_11345	COG1999	signal sequence binding
ES963_11355	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ES963_11360	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ES963_11365	COG1272	protein, Hemolysin III
ES963_11370	COG0204	Acyl-transferase
ES963_11375	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ES963_11380	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ES963_11390	COG2521	methyltransferase
ES963_11390	COG2136	Putative SAM-dependent methyltransferase
ES963_11400	COG0129	dihydroxy-acid dehydratase activity
ES963_11405	COG1413	lyase activity
ES963_11410	COG1418	mRNA catabolic process
ES963_11415	COG0386	Belongs to the glutathione peroxidase family
ES963_11420	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ES963_11425	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ES963_11435	COG1278	Cold shock
ES963_11455	COG0328	RNA-DNA hybrid ribonuclease activity
ES963_11460	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ES963_11465	COG0328	RNA-DNA hybrid ribonuclease activity
ES963_11475	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES963_11490	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ES963_11500	COG1755	Isoprenylcysteine carboxyl methyltransferase
ES963_11505	COG3424	synthase
ES963_11510	COG2233	PERMEase
ES963_11515	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ES963_11520	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ES963_11530	COG0800	Aldolase
ES963_11535	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES963_11540	COG1609	Transcriptional regulator
ES963_11545	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ES963_11550	COG1028	Short-chain dehydrogenase reductase Sdr
ES963_11555	COG1199	ATP-dependent helicase activity
ES963_11570	COG0116	Belongs to the methyltransferase superfamily
ES963_11585	COG4474	Belongs to the UPF0398 family
ES963_11600	COG3359	exonuclease
ES963_11605	COG1205	dead DEAH box helicase
ES963_11605	COG1111	helicase
ES963_11610	COG2190	(PTS) system
ES963_11615	COG0071	Belongs to the small heat shock protein (HSP20) family
ES963_11650	COG3331	DNA recombination
ES963_11655	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES963_11655	COG4499	WXG100 protein secretion system (Wss), protein YukC
ES963_11665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ES963_11670	COG3935	DnaD domain protein
ES963_11675	COG0017	Asparaginyl-tRNA synthetase
ES963_11680	COG0436	Aminotransferase
ES963_11685	COG5353	protein conserved in bacteria
ES963_11695	COG1199	ATP-dependent helicase activity
ES963_11695	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ES963_11700	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ES963_11705	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ES963_11710	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ES963_11715	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ES963_11715	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ES963_11720	COG0617	tRNA 3'-terminal CCA addition
ES963_11725	COG0438	transferase activity, transferring glycosyl groups
ES963_11730	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES963_11735	COG1803	Methylglyoxal synthase
ES963_11740	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ES963_11745	COG1694	Mazg nucleotide pyrophosphohydrolase
ES963_11750	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES963_11760	COG4347	Protein of unknown function (DUF1405)
ES963_11765	COG2010	Cytochrome c
ES963_11765	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ES963_11770	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ES963_11775	COG0723	plastoquinol--plastocyanin reductase activity
ES963_11785	COG5582	Belongs to the UPF0302 family
ES963_11790	COG0457	Tetratricopeptide repeat
ES963_11795	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ES963_11800	COG0287	Prephenate dehydrogenase
ES963_11810	COG0159	tryptophan synthase activity
ES963_11815	COG0133	tryptophan synthase activity
ES963_11820	COG0135	phosphoribosylanthranilate isomerase activity
ES963_11830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ES963_11835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ES963_11840	COG4401	Chorismate mutase type I
ES963_11845	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ES963_11850	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ES963_11855	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ES963_11860	COG0105	UTP biosynthetic process
ES963_11865	COG0142	geranyltranstransferase activity
ES963_11870	COG2226	methyltransferase
ES963_11875	COG0142	geranyltranstransferase activity
ES963_11885	COG0302	gtp cyclohydrolase
ES963_11890	COG0776	regulation of translation
ES963_11895	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ES963_11910	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ES963_11915	COG1160	GTP binding
ES963_11940	COG1304	FMN binding
ES963_11945	COG0539	negative regulation of cytoplasmic translation
ES963_11950	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ES963_11960	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
ES963_11965	COG2959	enzyme of heme biosynthesis
ES963_11970	COG3409	Peptidoglycan-binding domain 1 protein
ES963_11970	COG3773	Cell wall hydrolase
ES963_11975	COG2339	peptidase activity
ES963_11980	COG0492	ferredoxin-NADP+ reductase activity
ES963_11985	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES963_11990	COG4862	establishment of competence for transformation
ES963_11995	COG1408	metallophosphoesterase
ES963_12005	COG1388	LysM domain
ES963_12010	COG1266	CAAX protease self-immunity
ES963_12015	COG0514	ATP-dependent DNA helicase (RecQ)
ES963_12020	COG4955	Helix-turn-helix domain
ES963_12025	COG1141	Ferredoxin
ES963_12030	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ES963_12035	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ES963_12040	COG0710	3-dehydroquinate dehydratase activity
ES963_12050	COG1595	DNA-templated transcription, initiation
ES963_12055	COG5002	protein histidine kinase activity
ES963_12060	COG0745	RESPONSE REGULATOR receiver
ES963_12065	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ES963_12070	COG1333	cytochrome c biogenesis protein
ES963_12075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES963_12080	COG1187	pseudouridine synthase activity
ES963_12085	COG0700	Nucleoside recognition
ES963_12090	COG2715	membrane protein required for spore maturation
ES963_12095	COG1686	Belongs to the peptidase S11 family
ES963_12105	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ES963_12110	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ES963_12115	COG1547	Domain of unknown function (DUF309)
ES963_12120	COG0456	acetyltransferase
ES963_12125	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ES963_12130	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ES963_12130	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ES963_12135	COG0307	riboflavin synthase, alpha
ES963_12140	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ES963_12140	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ES963_12150	COG0681	Belongs to the peptidase S26 family
ES963_12155	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
ES963_12190	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ES963_12200	COG4086	secreted protein
ES963_12205	COG0019	diaminopimelate decarboxylase activity
ES963_12210	COG0697	spore germination
ES963_12225	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES963_12245	COG1191	sigma factor activity
ES963_12250	COG2172	sigma factor antagonist activity
ES963_12255	COG1366	Belongs to the anti-sigma-factor antagonist family
ES963_12260	COG1686	Belongs to the peptidase S11 family
ES963_12265	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ES963_12270	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ES963_12275	COG4974	Belongs to the 'phage' integrase family
ES963_12285	COG0735	belongs to the Fur family
ES963_12290	COG1300	Membrane
ES963_12300	COG0281	malic enzyme
ES963_12305	COG1757	Na H antiporter
ES963_12310	COG1027	Aspartate ammonia-lyase
ES963_12315	COG0252	asparaginase activity
ES963_12320	COG1396	sequence-specific DNA binding
ES963_12325	COG1379	DNA repair
ES963_12330	COG0494	nUDIX hydrolase
ES963_12340	COG0667	Aldo Keto reductase
ES963_12350	COG1073	alpha beta
ES963_12360	COG4918	Iron-sulphur cluster biosynthesis
ES963_12365	COG0456	acetyltransferase
ES963_12365	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ES963_12370	COG2329	Antibiotic biosynthesis monooxygenase
ES963_12375	COG0456	acetyltransferase
ES963_12385	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ES963_12395	COG2211	Major facilitator Superfamily
ES963_12400	COG0346	lactoylglutathione lyase activity
ES963_12405	COG1072	(Pantothenic acid kinase))
ES963_12410	COG3048	D-serine ammonia-lyase activity
ES963_12415	COG0300	oxidoreductase activity
ES963_12420	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES963_12425	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES963_12430	COG4187	Peptidase family M20/M25/M40
ES963_12435	COG1902	pentaerythritol trinitrate reductase activity
ES963_12440	COG0596	Alpha beta hydrolase
ES963_12450	COG1234	tRNA 3'-trailer cleavage
ES963_12455	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ES963_12460	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ES963_12465	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ES963_12475	COG0706	membrane insertase activity
ES963_12480	COG3361	conserved protein (COG2071)
ES963_12485	COG2195	Cleaves the N-terminal amino acid of tripeptides
ES963_12490	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ES963_12495	COG0346	lactoylglutathione lyase activity
ES963_12500	COG1376	ErfK ybiS ycfS ynhG family protein
ES963_12505	COG4129	membrane
ES963_12510	COG1126	abc transporter atp-binding protein
ES963_12515	COG0765	amino acid transport
ES963_12520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES963_12530	COG1597	lipid kinase activity
ES963_12535	COG2814	Major facilitator Superfamily
ES963_12540	COG4978	Transcriptional regulator
ES963_12540	COG0789	Transcriptional regulator
ES963_12545	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES963_12550	COG0022	dehydrogenase e1 component
ES963_12555	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES963_12560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES963_12565	COG3426	butyrate kinase activity
ES963_12570	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES963_12575	COG0280	phosphate acetyltransferase
ES963_12580	COG3290	protein histidine kinase activity
ES963_12580	COG3829	transcription factor binding
ES963_12590	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ES963_12595	COG2079	MmgE PrpD family protein
ES963_12600	COG0372	Belongs to the citrate synthase family
ES963_12605	COG1960	acyl-CoA dehydrogenase activity
ES963_12610	COG1250	3-hydroxyacyl-CoA dehydrogenase
ES963_12615	COG0183	Belongs to the thiolase family
ES963_12620	COG0584	glycerophosphoryl diester phosphodiesterase
ES963_12625	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES963_12640	COG1902	pentaerythritol trinitrate reductase activity
ES963_12645	COG0745	RESPONSE REGULATOR receiver
ES963_12655	COG0750	zinc metalloprotease
ES963_12660	COG0497	DNA recombination
ES963_12665	COG1438	arginine binding
ES963_12670	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ES963_12675	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ES963_12680	COG0142	geranyltranstransferase activity
ES963_12685	COG1722	exodeoxyribonuclease VII activity
ES963_12690	COG1570	exodeoxyribonuclease VII activity
ES963_12695	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ES963_12700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ES963_12705	COG1302	Protein conserved in bacteria
ES963_12710	COG0439	Biotin carboxylase
ES963_12715	COG0511	ligase activity, forming carbon-carbon bonds
ES963_12755	COG3854	ATPases associated with a variety of cellular activities
ES963_12765	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ES963_12770	COG0006	proline dipeptidase activity
ES963_12775	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ES963_12785	COG3872	metal-dependent enzyme
ES963_12795	COG1752	Esterase of the alpha-beta hydrolase superfamily
ES963_12800	COG1321	iron dependent repressor
ES963_12805	COG0095	Lipoate-protein ligase
ES963_12810	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ES963_12815	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ES963_12820	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ES963_12825	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ES963_12830	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ES963_12845	COG1396	sequence-specific DNA binding
ES963_12855	COG0681	Belongs to the peptidase S26 family
ES963_12880	COG4940	Competence protein ComGF
ES963_12890	COG4970	Tfp pilus assembly protein FimT
ES963_12895	COG4537	Required for transformation and DNA binding
ES963_12900	COG1459	type II secretion system
ES963_12905	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ES963_12910	COG0517	IMP dehydrogenase activity
ES963_12915	COG0598	Magnesium transport protein CorA
ES963_12920	COG1253	flavin adenine dinucleotide binding
ES963_12925	COG1366	Belongs to the anti-sigma-factor antagonist family
ES963_12935	COG1393	Belongs to the ArsC family
ES963_12945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES963_12955	COG0011	TIGRFAM Protein of
ES963_12965	COG2866	Carboxypeptidase
ES963_12970	COG1368	sulfuric ester hydrolase activity
ES963_12975	COG1940	carbohydrate kinase activity
ES963_12980	COG4483	Protein conserved in bacteria
ES963_12985	COG0705	Rhomboid family
ES963_12985	COG0457	Tetratricopeptide repeat
ES963_12995	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ES963_13000	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ES963_13005	COG0438	transferase activity, transferring glycosyl groups
ES963_13020	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ES963_13025	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES963_13030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES963_13035	COG0581	inorganic phosphate transmembrane transporter activity
ES963_13040	COG0573	inorganic phosphate transmembrane transporter activity
ES963_13045	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ES963_13055	COG0477	Major facilitator Superfamily
ES963_13060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ES963_13065	COG2839	Protein conserved in bacteria
ES963_13070	COG5521	maltodextrose utilization protein MalA
ES963_13075	COG1388	LysM domain
ES963_13080	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ES963_13085	COG4709	membrane
ES963_13090	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
ES963_13095	COG0735	belongs to the Fur family
ES963_13100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES963_13110	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ES963_13115	COG0513	Belongs to the DEAD box helicase family
ES963_13125	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ES963_13130	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ES963_13135	COG2384	SAM-dependent methyltransferase
ES963_13140	COG2010	Cytochrome c
ES963_13150	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ES963_13155	COG0358	DNA primase activity
ES963_13160	COG1671	Belongs to the UPF0178 family
ES963_13165	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ES963_13170	COG0517	IMP dehydrogenase activity
ES963_13175	COG0751	glycine-tRNA ligase activity
ES963_13180	COG0752	glycyl-tRNA synthetase alpha subunit
ES963_13185	COG1381	Involved in DNA repair and RecF pathway recombination
ES963_13195	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ES963_13200	COG0295	cytidine deaminase activity
ES963_13205	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ES963_13210	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ES963_13215	COG1480	7TM receptor with intracellular HD hydrolase
ES963_13220	COG1702	phosphate starvation-inducible protein PhoH
ES963_13225	COG0561	phosphatase activity
ES963_13240	COG4864	UPF0365 protein
ES963_13245	COG1030	water channel activity
ES963_13250	COG1610	YqeY-like protein
ES963_13255	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ES963_13260	COG1283	sodium-dependent phosphate transmembrane transporter activity
ES963_13265	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ES963_13270	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ES963_13275	COG2264	protein methyltransferase activity
ES963_13280	COG0484	heat shock protein binding
ES963_13285	COG0443	Heat shock 70 kDa protein
ES963_13290	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ES963_13295	COG1420	regulation of RNA biosynthetic process
ES963_13300	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ES963_13305	COG0481	GTPase activity
ES963_13315	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES963_13320	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ES963_13325	COG0268	Binds directly to 16S ribosomal RNA
ES963_13330	COG1466	dna polymerase III delta subunit
ES963_13345	COG2333	competence protein COMEC
ES963_13345	COG0658	competence protein
ES963_13350	COG2131	deaminase
ES963_13355	COG1555	photosystem II stabilization
ES963_13355	COG1596	polysaccharide export
ES963_13360	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES963_13365	COG2226	methyltransferase
ES963_13370	COG0799	negative regulation of ribosome biogenesis
ES963_13375	COG1713	HD superfamily hydrolase involved in NAD metabolism
ES963_13380	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ES963_13385	COG1534	Rna-binding protein
ES963_13390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ES963_13395	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ES963_13400	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ES963_13410	COG2755	lipolytic protein G-D-S-L family
ES963_13415	COG3409	Peptidoglycan-binding domain 1 protein
ES963_13415	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES963_13420	COG0398	Pfam SNARE associated Golgi protein
ES963_13425	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ES963_13435	COG3209	COG3209 Rhs family protein
ES963_13455	COG0114	fumarate hydratase activity
ES963_13475	COG0457	Tetratricopeptide repeat
ES963_13600	COG0789	Transcriptional regulator
ES963_13600	COG4978	Transcriptional regulator
ES963_13605	COG2814	Major facilitator Superfamily
ES963_13610	COG0456	acetyltransferase
ES963_13615	COG1253	flavin adenine dinucleotide binding
ES963_13625	COG0697	spore germination
ES963_13630	COG0583	DNA-binding transcription factor activity
ES963_13635	COG2072	flavoprotein involved in K transport
ES963_13640	COG1230	cation diffusion facilitator family transporter
ES963_13650	COG1114	Component of the transport system for branched-chain amino acids
ES963_13655	COG1687	branched-chain amino acid
ES963_13660	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ES963_13665	COG1522	sequence-specific DNA binding
ES963_13670	COG2732	(Barnase) inhibitor
ES963_13675	COG2124	cytochrome p450
ES963_13685	COG1335	isochorismatase
ES963_13700	COG2318	DinB family
ES963_13710	COG2070	2-Nitropropane dioxygenase
ES963_13725	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ES963_13745	COG3443	Belongs to the bacterial solute-binding protein 9 family
ES963_13750	COG1595	DNA-templated transcription, initiation
ES963_13755	COG0667	Aldo Keto reductase
ES963_13760	COG2851	Citrate transporter
ES963_13765	COG0583	DNA-binding transcription factor activity
ES963_13770	COG2828	Protein conserved in bacteria
ES963_13775	COG3409	Peptidoglycan-binding domain 1 protein
ES963_13780	COG5566	PFAM Mor transcription activator
ES963_13785	COG0596	Alpha beta hydrolase
ES963_13790	COG4991	sh3 domain protein
ES963_13795	COG4991	sh3 domain protein
ES963_13805	COG0346	lactoylglutathione lyase activity
ES963_13815	COG5577	PFAM Coat F domain
ES963_13820	COG1063	alcohol dehydrogenase
ES963_13830	COG5577	PFAM Coat F domain
ES963_13835	COG0789	Transcriptional regulator
ES963_13845	COG1064	alcohol dehydrogenase
ES963_13850	COG0693	protein deglycase activity
ES963_13855	COG1621	beta-fructofuranosidase activity
ES963_13860	COG3716	PTS system mannose fructose sorbose family IID component
ES963_13865	COG3715	PTS system
ES963_13870	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES963_13875	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES963_13880	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ES963_13880	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ES963_13890	COG1113	amino acid transport
ES963_13895	COG1280	lysine exporter protein (LysE YggA)
ES963_13900	COG1378	Sugar-specific transcriptional regulator TrmB
ES963_13905	COG1595	DNA-templated transcription, initiation
ES963_13915	COG2755	lipolytic protein G-D-S-L family
ES963_13915	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ES963_13925	COG2124	cytochrome p450
ES963_13925	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ES963_13930	COG1309	transcriptional regulator
ES963_13935	COG2226	methyltransferase
ES963_13950	COG2116	formate transmembrane transporter activity
ES963_13955	COG5609	conserved protein (DUF2294)
ES963_13960	COG3383	formate dehydrogenase (NAD+) activity
ES963_13965	COG2427	Protein of unknown function (DUF1641)
ES963_13975	COG0626	cystathionine gamma-synthase activity
ES963_13980	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES963_13985	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ES963_13990	COG2226	methyltransferase
ES963_14005	COG0768	penicillin binding
ES963_14010	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ES963_14015	COG0572	uridine kinase
ES963_14035	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ES963_14040	COG3906	Belongs to the UPF0473 family
ES963_14045	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ES963_14050	COG4472	Bacterial protein of unknown function (DUF965)
ES963_14055	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ES963_14060	COG0628	permease
ES963_14065	COG1126	abc transporter atp-binding protein
ES963_14070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES963_14075	COG0765	amino acid transport
ES963_14080	COG0765	amino acid transport
ES963_14095	COG3881	PFAM PRC-barrel domain
ES963_14100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ES963_14105	COG0457	Tetratricopeptide repeat
ES963_14110	COG0482	sulfurtransferase activity
ES963_14115	COG1104	cysteine desulfurase activity
ES963_14120	COG1959	2 iron, 2 sulfur cluster binding
ES963_14125	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ES963_14130	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ES963_14140	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ES963_14145	COG0124	histidyl-tRNA synthetase
ES963_14155	COG4991	sh3 domain protein
ES963_14155	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES963_14155	COG3103	Sh3 type 3 domain protein
ES963_14160	COG1490	D-aminoacyl-tRNA deacylase activity
ES963_14165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ES963_14170	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ES963_14175	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ES963_14175	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ES963_14180	COG5416	Lipopolysaccharide assembly protein A domain
ES963_14185	COG0490	domain, Protein
ES963_14190	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ES963_14190	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ES963_14200	COG2244	polysaccharide biosynthetic process
ES963_14205	COG2323	membrane
ES963_14215	COG1862	Preprotein translocase
ES963_14220	COG0343	queuine tRNA-ribosyltransferase activity
ES963_14225	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ES963_14235	COG2255	four-way junction helicase activity
ES963_14240	COG0632	four-way junction helicase activity
ES963_14250	COG2814	Major facilitator Superfamily
ES963_14255	COG0673	inositol 2-dehydrogenase activity
ES963_14260	COG2112	serine threonine protein kinase
ES963_14280	COG1115	amino acid carrier protein
ES963_14285	COG0217	transcriptional regulatory protein
ES963_14295	COG1388	LysM domain
ES963_14300	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ES963_14305	COG0157	Belongs to the NadC ModD family
ES963_14310	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ES963_14315	COG1104	cysteine desulfurase activity
ES963_14320	COG1827	regulation of RNA biosynthetic process
ES963_14325	COG0077	Prephenate dehydratase
ES963_14330	COG4492	Belongs to the UPF0735 family
ES963_14335	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ES963_14340	COG3290	protein histidine kinase activity
ES963_14350	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ES963_14355	COG2868	ribosomal protein
ES963_14360	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ES963_14365	COG1994	Peptidase M50
ES963_14370	COG0739	heme binding
ES963_14375	COG2894	cell division
ES963_14380	COG0850	regulation of cytokinetic process
ES963_14385	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ES963_14390	COG1792	Involved in formation and maintenance of cell shape
ES963_14395	COG1077	Cell shape determining protein MreB Mrl
ES963_14400	COG2003	Belongs to the UPF0758 family
ES963_14405	COG0424	maF-like protein
ES963_14415	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ES963_14420	COG0285	dihydrofolate synthase activity
ES963_14425	COG0525	valine-tRNA ligase activity
ES963_14435	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES963_14440	COG1388	LysM domain
ES963_14445	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ES963_14450	COG0113	porphobilinogen synthase activity
ES963_14455	COG1587	Uroporphyrinogen-III synthase
ES963_14460	COG0181	hydroxymethylbilane synthase activity
ES963_14465	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ES963_14470	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ES963_14480	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ES963_14485	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ES963_14490	COG1067	ATP-dependent peptidase activity
ES963_14490	COG0470	DNA polymerase III
ES963_14495	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ES963_14500	COG0544	peptidyl-prolyl cis-trans isomerase activity
ES963_14505	COG0457	Tetratricopeptide repeat
ES963_14505	COG1477	protein flavinylation
ES963_14510	COG0066	3-isopropylmalate dehydratase activity
ES963_14515	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ES963_14520	COG0473	3-isopropylmalate dehydrogenase activity
ES963_14525	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ES963_14530	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ES963_14535	COG0440	acetolactate synthase activity
ES963_14540	COG0028	Belongs to the TPP enzyme family
ES963_14550	COG0454	-acetyltransferase
ES963_14555	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
ES963_14565	COG0622	Phosphoesterase
ES963_14570	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ES963_14575	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ES963_14580	COG5401	PFAM Sporulation and spore germination
ES963_14585	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ES963_14590	COG1846	Transcriptional regulator
ES963_14595	COG2197	response regulator
ES963_14600	COG0824	Thioesterase
ES963_14605	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ES963_14610	COG1053	succinate dehydrogenase
ES963_14615	COG2009	succinate dehydrogenase
ES963_14620	COG1719	4-vinyl reductase, 4VR
ES963_14625	COG0527	aspartate kinase activity
ES963_14635	COG0322	excinuclease ABC activity
ES963_14640	COG3118	belongs to the thioredoxin family
ES963_14650	COG3534	alpha-L-arabinofuranosidase
ES963_14655	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ES963_14660	COG2086	electron transfer activity
ES963_14665	COG1024	Enoyl-CoA hydratase
ES963_14670	COG1309	transcriptional regulator
ES963_14675	COG0318	PFAM AMP-dependent synthetase and ligase
ES963_14680	COG3766	membrane
ES963_14685	COG1193	negative regulation of DNA recombination
ES963_14690	COG1796	DNA polymerase
ES963_14690	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ES963_14695	COG1286	toxin biosynthetic process
ES963_14700	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ES963_14705	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ES963_14710	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES963_14710	COG0072	phenylalanine-tRNA ligase activity
ES963_14715	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ES963_14725	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ES963_14735	COG3835	regulator
ES963_14740	COG0277	FAD linked oxidase domain protein
ES963_14745	COG0247	lactate metabolic process
ES963_14750	COG0346	lactoylglutathione lyase activity
ES963_14760	COG1966	Carbon starvation protein
ES963_14765	COG3534	alpha-L-arabinofuranosidase
ES963_14770	COG0395	ABC-type sugar transport system, permease component
ES963_14775	COG1175	transmembrane transport
ES963_14780	COG1653	transport
ES963_14785	COG0371	Dehydrogenase
ES963_14790	COG0647	UMP catabolic process
ES963_14795	COG0235	Class ii aldolase
ES963_14800	COG1069	ribulokinase activity
ES963_14805	COG2160	L-arabinose isomerase activity
ES963_14810	COG3507	Belongs to the glycosyl hydrolase 43 family
ES963_14815	COG1363	Peptidase, m42
ES963_14825	COG3326	Membrane
ES963_14830	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ES963_14835	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ES963_14840	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ES963_14850	COG1346	cytolysis
ES963_14855	COG1380	Effector of murein hydrolase LrgA
ES963_14860	COG3279	Response regulator of the LytR AlgR family
ES963_14865	COG3275	phosphorelay sensor kinase activity
ES963_14875	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ES963_14885	COG0398	Pfam SNARE associated Golgi protein
ES963_14890	COG1484	DNA-dependent DNA replication
ES963_14895	COG3611	Membrane attachment protein
ES963_14900	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ES963_14905	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ES963_14910	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ES963_14925	COG0656	L-ascorbic acid biosynthetic process
ES963_14930	COG0237	dephospho-CoA kinase activity
ES963_14935	COG1971	Probably functions as a manganese efflux pump
ES963_14940	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ES963_14945	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES963_14945	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES963_14950	COG5002	protein histidine kinase activity
ES963_14955	COG0745	RESPONSE REGULATOR receiver
ES963_14960	COG0039	L-malate dehydrogenase activity
ES963_14965	COG0538	isocitrate dehydrogenase activity
ES963_14970	COG0372	Belongs to the citrate synthase family
ES963_14975	COG2707	UPF0756 membrane protein
ES963_14980	COG0628	permease
ES963_14985	COG3030	protein affecting phage T7 exclusion by the F plasmid
ES963_14990	COG0469	pyruvate kinase activity
ES963_14995	COG0205	6-phosphofructokinase activity
ES963_15000	COG0825	malonyl-CoA metabolic process
ES963_15005	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ES963_15010	COG0281	malic enzyme
ES963_15015	COG0587	DNA-directed DNA polymerase activity
ES963_15035	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ES963_15045	COG4109	DRTGG domain
ES963_15050	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ES963_15055	COG1028	Short-chain dehydrogenase reductase Sdr
ES963_15065	COG0165	Argininosuccinate lyase
ES963_15070	COG0137	argininosuccinate synthase activity
ES963_15075	COG0521	Mo-molybdopterin cofactor biosynthetic process
ES963_15080	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ES963_15090	COG0827	DNA restriction-modification system
ES963_15095	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ES963_15100	COG3874	Sporulation protein YtfJ
ES963_15110	COG1714	RDD family
ES963_15115	COG0616	signal peptide processing
ES963_15120	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ES963_15125	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ES963_15130	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ES963_15140	COG0301	tRNA thio-modification
ES963_15145	COG1104	cysteine desulfurase activity
ES963_15150	COG1114	Component of the transport system for branched-chain amino acids
ES963_15155	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ES963_15160	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ES963_15165	COG1309	transcriptional regulator
ES963_15170	COG1956	GAF domain-containing protein
ES963_15175	COG2199	diguanylate cyclase activity
ES963_15175	COG2203	Gaf domain
ES963_15185	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ES963_15190	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ES963_15195	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ES963_15200	COG0454	-acetyltransferase
ES963_15205	COG0517	IMP dehydrogenase activity
ES963_15210	COG0123	including yeast histone deacetylase and acetoin utilization protein
ES963_15215	COG1360	Flagellar Motor Protein
ES963_15220	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ES963_15225	COG1609	Transcriptional regulator
ES963_15230	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ES963_15230	COG1605	Chorismate mutase
ES963_15235	COG3118	belongs to the thioredoxin family
ES963_15240	COG4980	gas vesicle protein
ES963_15245	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ES963_15250	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ES963_15255	COG1674	ftsk spoiiie
ES963_15260	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES963_15265	COG4848	Belongs to the UPF0354 family
ES963_15270	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES963_15285	COG1363	Peptidase, m42
ES963_15290	COG5584	Small secreted protein
ES963_15295	COG0281	malic enzyme
ES963_15300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES963_15305	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ES963_15315	COG0510	thiamine kinase activity
ES963_15320	COG1523	belongs to the glycosyl hydrolase 13 family
ES963_15325	COG1597	lipid kinase activity
ES963_15335	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ES963_15340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES963_15345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES963_15350	COG2252	PERMEase
ES963_15355	COG4473	ABC transporter
ES963_15360	COG1131	(ABC) transporter
ES963_15365	COG1349	DNA-binding transcription factor activity
ES963_15370	COG1187	pseudouridine synthase activity
ES963_15375	COG2244	polysaccharide biosynthetic process
ES963_15380	COG2081	HI0933 family
ES963_15385	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ES963_15395	COG5578	integral membrane protein
ES963_15400	COG0673	inositol 2-dehydrogenase activity
ES963_15405	COG1653	transport
ES963_15410	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ES963_15415	COG4209	transmembrane transport
ES963_15420	COG2207	Transcriptional regulator
ES963_15425	COG1653	transport
ES963_15430	COG0395	ABC-type sugar transport system, permease component
ES963_15435	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES963_15445	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ES963_15455	COG0156	8-amino-7-oxononanoate synthase activity
ES963_15460	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES963_15470	COG1073	alpha beta
ES963_15495	COG1486	melibiose metabolic process
ES963_15500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ES963_15505	COG0495	leucyl-tRNA aminoacylation
ES963_15515	COG1366	Belongs to the anti-sigma-factor antagonist family
ES963_15515	COG2202	Pas domain
ES963_15520	COG2814	Major facilitator Superfamily
ES963_15525	COG2433	Pfam Transposase IS66
ES963_15530	COG0577	efflux transmembrane transporter activity
ES963_15535	COG1136	(ABC) transporter
ES963_15540	COG2205	protein histidine kinase activity
ES963_15545	COG0745	RESPONSE REGULATOR receiver
ES963_15550	COG0577	efflux transmembrane transporter activity
ES963_15555	COG1136	(ABC) transporter
ES963_15570	COG1131	(ABC) transporter
ES963_15575	COG1725	Transcriptional regulator
ES963_15590	COG1242	4 iron, 4 sulfur cluster binding
ES963_15595	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ES963_15605	COG2267	carboxylic ester hydrolase activity
ES963_15610	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ES963_15615	COG1113	amino acid transport
ES963_15620	COG0367	asparagine synthase
ES963_15625	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ES963_15630	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ES963_15640	COG1506	peptidase
ES963_15645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ES963_15650	COG1116	anion transmembrane transporter activity
ES963_15655	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ES963_15660	COG0494	nUDIX hydrolase
ES963_15665	COG4824	toxin secretion phage lysis holin
ES963_15670	COG0783	Belongs to the Dps family
ES963_15685	COG1854	S-ribosylhomocysteine lyase activity
ES963_15690	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ES963_15695	COG0288	reversible hydration of carbon dioxide
ES963_15700	COG0254	rRNA binding
ES963_15705	COG1271	oxidase subunit
ES963_15710	COG1294	oxidase, subunit
ES963_15720	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES963_15725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES963_15725	COG1321	iron dependent repressor
ES963_15730	COG1121	(ABC) transporter
ES963_15735	COG0803	Belongs to the bacterial solute-binding protein 9 family
ES963_15740	COG4948	Mandelate Racemase Muconate Lactonizing
ES963_15745	COG0318	PFAM AMP-dependent synthetase and ligase
ES963_15750	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ES963_15755	COG0596	Alpha beta hydrolase
ES963_15760	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ES963_15765	COG1169	isochorismate synthase
ES963_15775	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES963_15780	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ES963_15785	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ES963_15790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES963_15795	COG0438	transferase activity, transferring glycosyl groups
ES963_15805	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES963_15810	COG0438	transferase activity, transferring glycosyl groups
ES963_15815	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES963_15820	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ES963_15825	COG0058	SHG alpha-glucan phosphorylase activity
ES963_15830	COG0297	glycogen (starch) synthase activity
ES963_15835	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ES963_15840	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ES963_15845	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ES963_15970	COG3859	Proton-coupled thiamine transporter YuaJ
ES963_15975	COG1247	-acetyltransferase
ES963_15980	COG2268	Band 7 protein
ES963_15985	COG1585	Membrane protein implicated in regulation of membrane protease activity
ES963_15990	COG2318	DinB family
ES963_16000	COG1454	alcohol dehydrogenase
ES963_16010	COG1510	regulation of RNA biosynthetic process
ES963_16020	COG0569	domain protein
ES963_16025	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ES963_16030	COG4682	membrane
ES963_16035	COG1705	Flagellar rod assembly protein muramidase FlgJ
ES963_16040	COG0477	Major facilitator Superfamily
ES963_16045	COG5553	Cysteine dioxygenase type I
ES963_16065	COG1674	ftsk spoiiie
ES963_16095	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES963_16095	COG3409	Peptidoglycan-binding domain 1 protein
ES963_16095	COG1388	LysM domain
ES963_16135	COG3953	SLT domain
ES963_16135	COG5280	Phage tail tape measure protein TP901
ES963_16180	COG0740	serine-type endopeptidase activity
ES963_16225	COG1216	Glycosyl transferase, family 2
ES963_16225	COG1442	glycosyl transferase family 8
ES963_16295	COG1388	LysM domain
ES963_16295	COG3584	3D domain protein
ES963_16300	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
ES963_16315	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES963_16335	COG1780	Probably involved in ribonucleotide reductase function
ES963_16370	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES963_16370	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES963_16440	COG1484	DNA-dependent DNA replication
ES963_16490	COG4974	Belongs to the 'phage' integrase family
ES963_16500	COG1968	undecaprenyl-diphosphatase activity
ES963_16505	COG0628	permease
ES963_16510	COG0673	inositol 2-dehydrogenase activity
ES963_16515	COG4806	L-rhamnose isomerase
ES963_16520	COG3254	rhamnose metabolic process
ES963_16525	COG1070	Carbohydrate kinase
ES963_16530	COG1349	DNA-binding transcription factor activity
ES963_16535	COG3347	Dehydrogenase
ES963_16535	COG1028	Short-chain dehydrogenase reductase Sdr
ES963_16545	COG0840	transmembrane signaling receptor activity
ES963_16550	COG0840	transmembrane signaling receptor activity
ES963_16555	COG0840	transmembrane signaling receptor activity
ES963_16560	COG0840	transmembrane signaling receptor activity
ES963_16575	COG0432	Pfam Uncharacterised protein family UPF0047
ES963_16585	COG0366	Alpha amylase catalytic
ES963_16590	COG1253	flavin adenine dinucleotide binding
ES963_16595	COG2738	Putative neutral zinc metallopeptidase
ES963_16610	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ES963_16625	COG0166	Belongs to the GPI family
ES963_16630	COG1979	alcohol dehydrogenase
ES963_16635	COG1979	alcohol dehydrogenase
ES963_16640	COG2155	Conserved Protein
ES963_16645	COG1098	S1 RNA binding domain
ES963_16650	COG0436	Aminotransferase
ES963_16655	COG1522	sequence-specific DNA binding
ES963_16660	COG2267	carboxylic ester hydrolase activity
ES963_16670	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ES963_16675	COG2205	protein histidine kinase activity
ES963_16685	COG5018	Exonuclease
ES963_16695	COG2814	Major facilitator Superfamily
ES963_16700	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES963_16705	COG3011	Protein conserved in bacteria
ES963_16715	COG3290	protein histidine kinase activity
ES963_16720	COG4565	transcriptional regulatory protein
ES963_16745	COG3493	citrate carrier protein
ES963_16755	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ES963_16755	COG2111	Na H antiporter
ES963_16760	COG2111	Na H antiporter
ES963_16765	COG1006	Multisubunit Na H antiporter MnhC subunit
ES963_16770	COG0651	ATP synthesis coupled electron transport
ES963_16775	COG1863	multisubunit Na H antiporter MnhE subunit
ES963_16780	COG2212	antiporter activity
ES963_16785	COG1320	monovalent cation:proton antiporter activity
ES963_16790	COG2050	protein possibly involved in aromatic compounds catabolism
ES963_16795	COG2197	response regulator
ES963_16800	COG4585	Histidine kinase
ES963_16810	COG0142	geranyltranstransferase activity
ES963_16830	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ES963_16835	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ES963_16840	COG1335	isochorismatase
ES963_16845	COG5506	Protein of unknown function (DUF1694)
ES963_16860	COG0628	permease
ES963_16875	COG1418	mRNA catabolic process
ES963_16880	COG1028	Short-chain dehydrogenase reductase Sdr
ES963_16890	COG1511	domain protein
ES963_16895	COG0433	COG0433 Predicted ATPase
ES963_16895	COG1674	ftsk spoiiie
ES963_16900	COG4499	WXG100 protein secretion system (Wss), protein YukC
ES963_16905	COG5417	Belongs to the EsaB family
ES963_16910	COG4842	Belongs to the WXG100 family
ES963_16920	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ES963_16920	COG2508	Transcriptional regulator
ES963_16925	COG0686	Belongs to the AlaDH PNT family
ES963_16930	COG5634	Uncharacterized conserved protein (DUF2278)
ES963_16935	COG3251	PFAM MbtH domain protein
ES963_16940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES963_16945	COG3433	isochorismatase activity
ES963_16945	COG1535	isochorismatase
ES963_16950	COG1021	2,3-dihydroxybenzoate-AMP ligase
ES963_16955	COG1169	isochorismate synthase
ES963_16960	COG1028	Short-chain dehydrogenase reductase Sdr
ES963_16965	COG2819	hydrolase of the alpha beta superfamily
ES963_16970	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ES963_16975	COG1268	BioY protein
ES963_16980	COG2056	Na+-H+ antiporter family
ES963_16985	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ES963_16990	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
ES963_16995	COG3584	3D domain protein
ES963_17010	COG1252	NADH dehydrogenase
ES963_17015	COG0492	ferredoxin-NADP+ reductase activity
ES963_17025	COG0516	GMP reductase activity
ES963_17030	COG2808	Putative FMN-binding domain
ES963_17035	COG0456	acetyltransferase
ES963_17040	COG0316	Belongs to the HesB IscA family
ES963_17045	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ES963_17050	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES963_17055	COG4844	belongs to the
ES963_17060	COG1252	NADH dehydrogenase
ES963_17065	COG4837	Protein of unknown function (DUF1462)
ES963_17070	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ES963_17075	COG0823	Involved in the tonB-independent uptake of proteins
ES963_17075	COG1506	peptidase
ES963_17075	COG4946	Tricorn protease homolog
ES963_17080	COG0083	homoserine kinase activity
ES963_17085	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ES963_17090	COG0460	homoserine dehydrogenase
ES963_17095	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES963_17100	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ES963_17105	COG0647	UMP catabolic process
ES963_17110	COG2445	Protein of unknown function DUF86
ES963_17115	COG4470	Protein conserved in bacteria
ES963_17125	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ES963_17130	COG0739	heme binding
ES963_17140	COG3377	Domain of unknown function (DUF1805)
ES963_17145	COG0737	Belongs to the 5'-nucleotidase family
ES963_17150	COG0730	response to heat
ES963_17155	COG1801	Protein of unknown function DUF72
ES963_17165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ES963_17170	COG2508	Transcriptional regulator
ES963_17175	COG2233	PERMEase
ES963_17180	COG2233	PERMEase
ES963_17185	COG3648	Uricase
ES963_17185	COG3195	allantoin biosynthetic process
ES963_17190	COG2351	hydroxyisourate hydrolase activity
ES963_17200	COG2080	2 iron, 2 sulfur cluster binding
ES963_17205	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ES963_17210	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ES963_17215	COG2068	MobA-Related Protein
ES963_17220	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ES963_17225	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ES963_17230	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES963_17240	COG2356	endonuclease I
ES963_17245	COG3842	ATPase activity
ES963_17250	COG2188	Transcriptional regulator
ES963_17255	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES963_17260	COG0395	ABC-type sugar transport system, permease component
ES963_17265	COG1175	transmembrane transport
ES963_17270	COG1653	transport
ES963_17275	COG2222	sugar isomerase
ES963_17280	COG0322	excinuclease ABC activity
ES963_17285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ES963_17300	COG0346	lactoylglutathione lyase activity
ES963_17305	COG0640	Transcriptional regulator
ES963_17310	COG0719	Fe-S assembly protein
ES963_17315	COG0822	iron-sulfur transferase activity
ES963_17320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ES963_17325	COG0719	Fe-S assembly protein
ES963_17330	COG0396	ATPase activity
ES963_17345	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ES963_17350	COG1464	Belongs to the NlpA lipoprotein family
ES963_17355	COG2011	ABC-type metal ion transport system permease component
ES963_17360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ES963_17370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES963_17375	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ES963_17385	COG0509	glycine decarboxylation via glycine cleavage system
ES963_17390	COG1393	Belongs to the ArsC family
ES963_17395	COG1960	acyl-CoA dehydrogenase activity
ES963_17400	COG0183	Belongs to the thiolase family
ES963_17405	COG1024	Enoyl-CoA hydratase
ES963_17405	COG1250	3-hydroxyacyl-CoA dehydrogenase
ES963_17415	COG0506	proline dehydrogenase activity
ES963_17425	COG5577	PFAM Coat F domain
ES963_17430	COG1846	Transcriptional regulator
ES963_17435	COG0477	Major facilitator Superfamily
ES963_17440	COG1942	4-Oxalocrotonate Tautomerase
ES963_17445	COG1028	Short-chain dehydrogenase reductase Sdr
ES963_17450	COG0583	DNA-binding transcription factor activity
ES963_17460	COG1120	ATPase activity
ES963_17480	COG1131	(ABC) transporter
ES963_17525	COG0783	Belongs to the Dps family
ES963_17530	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES963_17535	COG0745	RESPONSE REGULATOR receiver
ES963_17540	COG2205	protein histidine kinase activity
ES963_17540	COG2770	Histidine kinase
ES963_17550	COG1309	transcriptional regulator
ES963_17555	COG0114	fumarate hydratase activity
ES963_17565	COG0697	spore germination
ES963_17570	COG0814	amino acid
ES963_17580	COG2197	response regulator
ES963_17585	COG4585	Histidine kinase
ES963_17590	COG4758	membrane
ES963_17595	COG3595	metallopeptidase activity
ES963_17600	COG1842	Phage shock protein A
ES963_17605	COG4758	membrane
ES963_17610	COG2814	Major facilitator Superfamily
ES963_17615	COG2096	Adenosyltransferase
ES963_17620	COG1120	ATPase activity
ES963_17625	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES963_17630	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES963_17635	COG1028	Short-chain dehydrogenase reductase Sdr
ES963_17640	COG3386	PFAM SMP-30 Gluconolaconase
ES963_17645	COG2205	protein histidine kinase activity
ES963_17650	COG0745	RESPONSE REGULATOR receiver
ES963_17660	COG1191	sigma factor activity
ES963_17670	COG2140	Oxalate decarboxylase
ES963_17680	COG0577	efflux transmembrane transporter activity
ES963_17685	COG1136	(ABC) transporter
ES963_17690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ES963_17695	COG1120	ATPase activity
ES963_17700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES963_17705	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES963_17710	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES963_17720	COG0531	amino acid
ES963_17735	COG1988	membrane-bound metal-dependent
ES963_17740	COG1368	sulfuric ester hydrolase activity
ES963_17745	COG1910	domain protein
ES963_17750	COG0725	ABC transporter, periplasmic molybdate-binding protein
ES963_17755	COG4149	molybdate abc transporter
ES963_17760	COG0656	L-ascorbic acid biosynthetic process
ES963_17770	COG0025	NhaP-type Na H and K H
ES963_17775	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ES963_17780	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ES963_17785	COG3973	AAA domain
ES963_17795	COG2860	membrane
ES963_17800	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ES963_17805	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ES963_17810	COG2217	Heavy metal translocating P-type atpase
ES963_17815	COG2217	Heavy metal translocating P-type atpase
ES963_17820	COG2608	mercury ion transmembrane transporter activity
ES963_17825	COG1937	Protein conserved in bacteria
ES963_17830	COG0673	inositol 2-dehydrogenase activity
ES963_17835	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ES963_17840	COG1289	transmembrane transporter activity
ES963_17850	COG2076	Multidrug Resistance protein
ES963_17855	COG1309	transcriptional regulator
ES963_17860	COG1028	Short-chain dehydrogenase reductase Sdr
ES963_17870	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ES963_17875	COG0557	exoribonuclease II activity
ES963_17880	COG1647	Serine aminopeptidase, S33
ES963_17885	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ES963_17890	COG0596	Alpha beta hydrolase
ES963_17895	COG1476	TRANSCRIPTIONal
ES963_17900	COG1396	sequence-specific DNA binding
ES963_17905	COG1396	sequence-specific DNA binding
ES963_17910	COG1733	regulation of RNA biosynthetic process
ES963_17915	COG0840	transmembrane signaling receptor activity
ES963_17920	COG1174	glycine betaine transport
ES963_17925	COG1732	Glycine betaine
ES963_17930	COG1174	glycine betaine transport
ES963_17935	COG0517	IMP dehydrogenase activity
ES963_17935	COG1125	glycine betaine transport
ES963_17940	COG1510	regulation of RNA biosynthetic process
ES963_17945	COG1174	glycine betaine transport
ES963_17950	COG1732	Glycine betaine
ES963_17955	COG1174	glycine betaine transport
ES963_17960	COG0517	IMP dehydrogenase activity
ES963_17960	COG1125	glycine betaine transport
ES963_17965	COG1510	regulation of RNA biosynthetic process
ES963_17970	COG2095	MarC family integral membrane protein
ES963_17980	COG3064	Membrane
ES963_17985	COG4640	response to antibiotic
ES963_17990	COG0456	acetyltransferase
ES963_17995	COG0148	phosphopyruvate hydratase activity
ES963_18000	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ES963_18005	COG0149	triose-phosphate isomerase activity
ES963_18010	COG0126	phosphoglycerate kinase activity
ES963_18015	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ES963_18020	COG2390	Transcriptional regulator
ES963_18025	COG2814	Major facilitator Superfamily
ES963_18030	COG1609	Transcriptional regulator
ES963_18035	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES963_18045	COG0583	DNA-binding transcription factor activity
ES963_18050	COG0697	spore germination
ES963_18055	COG1113	amino acid transport
ES963_18060	COG3858	chitin binding
ES963_18065	COG1556	Lactate utilization protein
ES963_18070	COG1139	Iron-sulfur cluster binding protein
ES963_18075	COG0247	lactate metabolic process
ES963_18085	COG4585	Histidine kinase
ES963_18090	COG0842	Transport permease protein
ES963_18095	COG1131	(ABC) transporter
ES963_18100	COG0596	Alpha beta hydrolase
ES963_18105	COG2208	phosphoserine phosphatase activity
ES963_18115	COG1874	Beta-galactosidase
ES963_18120	COG3833	ABC-type maltose transport systems, permease component
ES963_18125	COG1175	transmembrane transport
ES963_18130	COG2182	Extracellular solute-binding protein
ES963_18135	COG1609	Transcriptional regulator
ES963_18140	COG2186	Transcriptional regulator
ES963_18145	COG1620	l-lactate permease
ES963_18150	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ES963_18160	COG5039	Polysaccharide pyruvyl transferase
ES963_18165	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES963_18170	COG0110	maltose O-acetyltransferase activity
ES963_18175	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ES963_18180	COG2244	polysaccharide biosynthetic process
ES963_18185	COG1216	Glycosyl transferase, family 2
ES963_18190	COG5039	Polysaccharide pyruvyl transferase
ES963_18195	COG1216	Glycosyl transferase, family 2
ES963_18205	COG0438	transferase activity, transferring glycosyl groups
ES963_18210	COG1215	transferase activity, transferring glycosyl groups
ES963_18215	COG0438	transferase activity, transferring glycosyl groups
ES963_18220	COG1086	Polysaccharide biosynthesis protein
ES963_18225	COG0489	protein tyrosine kinase activity
ES963_18230	COG3944	biosynthesis protein
ES963_18235	COG1396	sequence-specific DNA binding
ES963_18240	COG2272	Belongs to the type-B carboxylesterase lipase family
ES963_18260	COG1794	racemase activity, acting on amino acids and derivatives
ES963_18265	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ES963_18270	COG1621	beta-fructofuranosidase activity
ES963_18275	COG1621	beta-fructofuranosidase activity
ES963_18280	COG0531	amino acid
ES963_18285	COG1309	transcriptional regulator
ES963_18290	COG2076	Multidrug Resistance protein
ES963_18295	COG2076	Multidrug Resistance protein
ES963_18315	COG1674	ftsk spoiiie
ES963_18335	COG1388	LysM domain
ES963_18335	COG3409	Peptidoglycan-binding domain 1 protein
ES963_18335	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES963_18370	COG1705	Flagellar rod assembly protein muramidase FlgJ
ES963_18450	COG0582	viral genome integration into host DNA
ES963_18530	COG4974	Belongs to the 'phage' integrase family
ES963_18535	COG1793	dna ligase
ES963_18555	COG4974	Belongs to the 'phage' integrase family
ES963_18565	COG0740	serine-type endopeptidase activity
ES963_18570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ES963_18575	COG0366	Alpha amylase catalytic
ES963_18580	COG1554	hydrolase, family 65, central catalytic
ES963_18585	COG5521	maltodextrose utilization protein MalA
ES963_18590	COG3833	ABC-type maltose transport systems, permease component
ES963_18595	COG1175	transmembrane transport
ES963_18600	COG2182	Extracellular solute-binding protein
ES963_18605	COG0366	Alpha amylase catalytic
ES963_18610	COG1609	Transcriptional regulator
ES963_18615	COG1611	Belongs to the LOG family
ES963_18620	COG1694	Mazg nucleotide pyrophosphohydrolase
ES963_18625	COG0659	secondary active sulfate transmembrane transporter activity
ES963_18630	COG0288	reversible hydration of carbon dioxide
ES963_18635	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ES963_18640	COG0577	efflux transmembrane transporter activity
ES963_18645	COG1136	(ABC) transporter
ES963_18650	COG5002	protein histidine kinase activity
ES963_18655	COG0745	RESPONSE REGULATOR receiver
ES963_18665	COG2162	N-hydroxyarylamine O-acetyltransferase activity
ES963_18670	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES963_18675	COG1481	regulation of sporulation
ES963_18680	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ES963_18685	COG1660	Displays ATPase and GTPase activities
ES963_18690	COG1051	belongs to the nudix hydrolase family
ES963_18695	COG0492	ferredoxin-NADP+ reductase activity
ES963_18700	COG0791	NLP P60 protein
ES963_18700	COG3883	PFAM NLP P60 protein
ES963_18705	COG0457	Tetratricopeptide repeat
ES963_18710	COG1132	(ABC) transporter
ES963_18730	COG0140	phosphoribosyl-ATP diphosphatase activity
ES963_18730	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ES963_18735	COG0107	imidazoleglycerol-phosphate synthase activity
ES963_18740	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ES963_18745	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ES963_18750	COG0131	Imidazoleglycerol-phosphate dehydratase
ES963_18755	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ES963_18760	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ES963_18765	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ES963_18770	COG4990	cell redox homeostasis
ES963_18775	COG5297	Belongs to the glycosyl hydrolase family 6
ES963_18780	COG0110	maltose O-acetyltransferase activity
ES963_18785	COG0546	phosphoglycolate phosphatase activity
ES963_18790	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ES963_18795	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ES963_18800	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ES963_18805	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ES963_18810	COG0363	glucosamine-6-phosphate deaminase activity
ES963_18820	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ES963_18825	COG1846	Transcriptional regulator
ES963_18830	COG2124	cytochrome p450
ES963_18840	COG1846	Transcriptional regulator
ES963_18845	COG2814	Major facilitator Superfamily
ES963_18850	COG1950	PFAM Membrane protein of
ES963_18855	COG1983	PspC domain protein
ES963_18860	COG3595	metallopeptidase activity
ES963_18875	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ES963_18880	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ES963_18885	COG0556	nucleotide-excision repair
ES963_18890	COG4897	Protein conserved in bacteria
ES963_18895	COG3848	Pyruvate phosphate dikinase
ES963_18895	COG0574	Belongs to the PEP-utilizing enzyme family
ES963_18900	COG1309	transcriptional regulator
ES963_18905	COG2814	Major facilitator Superfamily
ES963_18910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES963_18920	COG3409	Peptidoglycan-binding domain 1 protein
ES963_18920	COG0793	Belongs to the peptidase S41A family
ES963_18925	COG2177	Part of the ABC transporter FtsEX involved in
ES963_18930	COG2884	Cell division ATP-binding protein ftsE
ES963_18935	COG2010	Cytochrome c
ES963_18940	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES963_18950	COG0653	protein targeting
ES963_18955	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ES963_18970	COG1516	flagellar protein fliS
ES963_18975	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ES963_18980	COG1334	flagellar protein FlaG
ES963_18985	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ES963_18990	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ES963_18995	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ES963_19005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ES963_19010	COG1256	bacterial-type flagellum assembly
ES963_19010	COG4786	Flagellar basal body rod
ES963_19015	COG3418	PFAM FlgN family protein
ES963_19020	COG2747	anti-sigma28 factor FlgM
ES963_19030	COG1040	competence protein
ES963_19040	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ES963_19045	COG1307	EDD domain protein, DegV family
ES963_19050	COG2197	response regulator
ES963_19055	COG4585	Histidine kinase
ES963_19060	COG1739	Uncharacterized protein family UPF0029
ES963_19065	COG1316	TRANSCRIPTIONal
ES963_19100	COG1131	(ABC) transporter
ES963_19110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ES963_19115	COG0438	transferase activity, transferring glycosyl groups
ES963_19120	COG1215	transferase activity, transferring glycosyl groups
ES963_19125	COG3206	protein involved in exopolysaccharide biosynthesis
ES963_19130	COG3307	-O-antigen
ES963_19140	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ES963_19145	COG0297	glycogen (starch) synthase activity
ES963_19145	COG0438	transferase activity, transferring glycosyl groups
ES963_19150	COG2244	polysaccharide biosynthetic process
ES963_19160	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES963_19160	COG2247	cell wall binding repeat
ES963_19165	COG2385	sporulation resulting in formation of a cellular spore
ES963_19165	COG2247	cell wall binding repeat
ES963_19180	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ES963_19185	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ES963_19195	COG1134	teichoic acid transport
ES963_19200	COG1682	transport, permease protein
ES963_19215	COG0463	Glycosyl transferase, family 2
ES963_19215	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES963_19220	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES963_19225	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ES963_19230	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ES963_19235	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES963_19240	COG4193	domain, Protein
ES963_19245	COG1482	cell wall glycoprotein biosynthetic process
ES963_19250	COG0697	spore germination
ES963_19255	COG0814	amino acid
ES963_19265	COG2814	Major facilitator Superfamily
ES963_19270	COG1316	TRANSCRIPTIONal
ES963_19275	COG0561	phosphatase activity
ES963_19280	COG0791	NLP P60 protein
ES963_19290	COG2843	Capsule synthesis protein
ES963_19300	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ES963_19305	COG1609	Transcriptional regulator
ES963_19310	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES963_19315	COG1869	D-ribose catabolic process
ES963_19320	COG1129	ABC transporter
ES963_19325	COG1172	Belongs to the binding-protein-dependent transport system permease family
ES963_19330	COG1879	ABC-type sugar transport system periplasmic component
ES963_19335	COG3103	Sh3 type 3 domain protein
ES963_19345	COG2249	NAD(P)H dehydrogenase (quinone) activity
ES963_19350	COG3527	Alpha-acetolactate decarboxylase
ES963_19355	COG0028	Belongs to the TPP enzyme family
ES963_19360	COG0583	DNA-binding transcription factor activity
ES963_19365	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ES963_19380	COG5337	Spore coat protein CotH
ES963_19390	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ES963_19400	COG0405	Gamma-glutamyltransferase
ES963_19405	COG1522	sequence-specific DNA binding
ES963_19410	COG2059	Chromate
ES963_19415	COG2059	Chromate
ES963_19425	COG0655	NAD(P)H dehydrogenase (quinone) activity
ES963_19430	COG0583	DNA-binding transcription factor activity
ES963_19460	COG5444	nuclease activity
ES963_19480	COG3878	Protein conserved in bacteria
ES963_19485	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ES963_19490	COG4464	protein tyrosine phosphatase activity
ES963_19495	COG0489	protein tyrosine kinase activity
ES963_19500	COG3944	biosynthesis protein
ES963_19510	COG4715	Zinc finger, swim domain protein
ES963_19515	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ES963_19520	COG0561	phosphatase activity
ES963_19525	COG1349	DNA-binding transcription factor activity
ES963_19530	COG0629	single-stranded DNA binding
ES963_19560	COG1970	mechanosensitive ion channel activity
ES963_19565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ES963_19570	COG0457	Tetratricopeptide repeat
ES963_19575	COG4786	Flagellar basal body rod
ES963_19580	COG4786	Flagellar basal body rod
ES963_19585	COG1077	Cell shape determining protein MreB Mrl
ES963_19590	COG1609	Transcriptional regulator
ES963_19600	COG1846	Transcriptional regulator
ES963_19605	COG2814	Major facilitator Superfamily
ES963_19610	COG3420	alginic acid biosynthetic process
ES963_19615	COG1953	Uracil, thiamine, allantoin
ES963_19620	COG0477	Major facilitator Superfamily
ES963_19625	COG1335	isochorismatase
ES963_19635	COG0004	ammonium transporteR
ES963_19640	COG0347	Belongs to the P(II) protein family
ES963_19645	COG0671	phosphoesterase, PA-phosphatase related
ES963_19655	COG0739	heme binding
ES963_19660	COG1247	-acetyltransferase
ES963_19670	COG2089	acid synthase
ES963_19680	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES963_19685	COG0789	Transcriptional regulator
ES963_19695	COG2910	NAD(P)H-binding
ES963_19700	COG1959	2 iron, 2 sulfur cluster binding
ES963_19705	COG0804	urea catabolic process
ES963_19710	COG0832	Belongs to the urease beta subunit family
ES963_19715	COG0831	urea catabolic process
ES963_19730	COG3237	CsbD-like
ES963_19735	COG1994	Peptidase M50
ES963_19740	COG0457	Tetratricopeptide repeat
ES963_19745	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ES963_19750	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ES963_19760	COG2304	oxidoreductase activity
ES963_19770	COG2304	oxidoreductase activity
ES963_19775	COG2385	sporulation resulting in formation of a cellular spore
ES963_19780	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ES963_19790	COG4836	Membrane
ES963_19800	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ES963_19805	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ES963_19810	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ES963_19815	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ES963_19820	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ES963_19825	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ES963_19830	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ES963_19835	COG0356	it plays a direct role in the translocation of protons across the membrane
ES963_19845	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ES963_19850	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ES963_19855	COG4475	Protein of unknown function (DUF436)
ES963_19860	COG0698	ribose 5-phosphate isomerase
ES963_19865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ES963_19870	COG1971	Probably functions as a manganese efflux pump
ES963_19875	COG0009	L-threonylcarbamoyladenylate synthase
ES963_19880	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ES963_19900	COG2890	protein-(glutamine-N5) methyltransferase activity
ES963_19905	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ES963_19910	COG0346	lactoylglutathione lyase activity
ES963_19915	COG0789	Transcriptional regulator
ES963_19920	COG0679	Auxin Efflux Carrier
ES963_19925	COG0281	malic enzyme
ES963_19930	COG1435	thymidine kinase activity
ES963_19935	COG0254	rRNA binding
ES963_19940	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ES963_19950	COG1494	fructose-1,6-bisphosphatase
ES963_19955	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ES963_19960	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ES963_19965	COG0191	fructose-bisphosphate aldolase activity
ES963_19970	COG2204	response regulator
ES963_19975	COG4821	SIS domain
ES963_19980	COG0504	CTP synthase activity
ES963_19985	COG3343	RNA polymerase activity
ES963_19990	COG1960	acyl-CoA dehydrogenase activity
ES963_19995	COG2181	nitrate reductase activity
ES963_19995	COG0247	lactate metabolic process
ES963_20000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES963_20005	COG4294	response to UV
ES963_20015	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ES963_20020	COG1132	(ABC) transporter
ES963_20025	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES963_20035	COG2181	nitrate reductase activity
ES963_20040	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ES963_20045	COG1140	nitrate reductase beta subunit
ES963_20050	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ES963_20055	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ES963_20065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ES963_20070	COG2223	nitrite transmembrane transporter activity
ES963_20075	COG0018	arginyl-trna synthetase
ES963_20080	COG4506	Protein conserved in bacteria
ES963_20095	COG0535	radical SAM domain protein
ES963_20105	COG1131	(ABC) transporter
ES963_20110	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ES963_20115	COG0612	Peptidase, M16
ES963_20120	COG0612	Peptidase, M16
ES963_20130	COG3391	amine dehydrogenase activity
ES963_20135	COG3391	amine dehydrogenase activity
ES963_20145	COG0457	Tetratricopeptide repeat
ES963_20160	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ES963_20165	COG0010	Belongs to the arginase family
ES963_20170	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ES963_20175	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES963_20190	COG1994	Peptidase M50
ES963_20195	COG1942	4-Oxalocrotonate Tautomerase
ES963_20200	COG1846	Transcriptional regulator
ES963_20205	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ES963_20215	COG0477	Major facilitator Superfamily
ES963_20220	COG1959	2 iron, 2 sulfur cluster binding
ES963_20225	COG3465	dGTPase activity
ES963_20230	COG1078	dGTPase activity
ES963_20235	COG4844	belongs to the
ES963_20245	COG0697	spore germination
ES963_20250	COG0095	Lipoate-protein ligase
ES963_20255	COG0583	DNA-binding transcription factor activity
ES963_20260	COG0280	phosphate acetyltransferase
ES963_20270	COG1028	Short-chain dehydrogenase reductase Sdr
ES963_20275	COG0436	Aminotransferase
ES963_20280	COG2814	Major facilitator Superfamily
ES963_20285	COG0151	Belongs to the GarS family
ES963_20290	COG1028	Short-chain dehydrogenase reductase Sdr
ES963_20295	COG1917	Cupin 2, conserved barrel domain protein
ES963_20300	COG0077	Prephenate dehydratase
ES963_20305	COG2814	Major facilitator Superfamily
ES963_20310	COG0833	amino acid
ES963_20315	COG4187	Peptidase family M20/M25/M40
ES963_20320	COG1012	belongs to the aldehyde dehydrogenase family
ES963_20325	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES963_20335	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ES963_20340	COG1091	dTDP-4-dehydrorhamnose reductase activity
ES963_20345	COG1088	dTDP-glucose 4,6-dehydratase activity
ES963_20350	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ES963_20355	COG3980	spore coat polysaccharide biosynthesis protein
ES963_20360	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
ES963_20365	COG2089	acid synthase
ES963_20370	COG0456	acetyltransferase
ES963_20375	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES963_20380	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES963_20385	COG0463	Glycosyl transferase, family 2
ES963_20400	COG2363	Small membrane protein
ES963_20405	COG2233	PERMEase
ES963_20415	COG1012	belongs to the aldehyde dehydrogenase family
ES963_20420	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ES963_20425	COG1216	Glycosyl transferase, family 2
ES963_20430	COG0351	phosphomethylpyrimidine kinase
ES963_20440	COG1621	beta-fructofuranosidase activity
ES963_20445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES963_20445	COG1263	PTS System
ES963_20450	COG2116	formate transmembrane transporter activity
ES963_20455	COG3711	transcriptional antiterminator
ES963_20465	COG1404	Belongs to the peptidase S8 family
ES963_20470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES963_20475	COG0778	Nitroreductase
ES963_20480	COG0772	Belongs to the SEDS family
ES963_20495	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ES963_20500	COG1845	cytochrome c oxidase, subunit III
ES963_20505	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ES963_20510	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ES963_20515	COG2261	transglycosylase associated protein
ES963_20520	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ES963_20525	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ES963_20530	COG2246	polysaccharide biosynthetic process
ES963_20535	COG1309	transcriptional regulator
ES963_20545	COG3162	membrane
ES963_20550	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES963_20555	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ES963_20560	COG2837	iron assimilation
ES963_20565	COG2822	iron ion transport
ES963_20570	COG0672	)-iron permease
ES963_20575	COG0352	thiamine-phosphate diphosphorylase activity
ES963_20580	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ES963_20585	COG0583	DNA-binding transcription factor activity
ES963_20590	COG1380	Effector of murein hydrolase LrgA
ES963_20595	COG1346	cytolysis
ES963_20600	COG2814	Major facilitator Superfamily
ES963_20605	COG4895	conserved protein (DUF2196)
ES963_20610	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ES963_20615	COG0346	lactoylglutathione lyase activity
ES963_20625	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES963_20630	COG1404	Belongs to the peptidase S8 family
ES963_20635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES963_20635	COG1263	PTS System
ES963_20640	COG3711	transcriptional antiterminator
ES963_20645	COG1442	glycosyl transferase family 8
ES963_20650	COG5522	Integral membrane protein (intg_mem_TP0381)
ES963_20655	COG1846	Transcriptional regulator
ES963_20660	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ES963_20665	COG2234	aminopeptidase activity
ES963_20670	COG2357	RelA SpoT domain protein
ES963_20680	COG1575	Belongs to the MenA family. Type 1 subfamily
ES963_20700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES963_20705	COG1696	Membrane protein involved in D-alanine export
ES963_20710	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES963_20715	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ES963_20720	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
ES963_20725	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES963_20730	COG1486	melibiose metabolic process
ES963_20735	COG1447	Phosphotransferase system cellobiose-specific component IIA
ES963_20740	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES963_20745	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES963_20750	COG3711	transcriptional antiterminator
ES963_20750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES963_20760	COG2094	Belongs to the DNA glycosylase MPG family
ES963_20765	COG0753	catalase activity
ES963_20770	COG2814	Major facilitator Superfamily
ES963_20775	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES963_20780	COG1131	(ABC) transporter
ES963_20800	COG1595	DNA-templated transcription, initiation
ES963_20805	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ES963_20810	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ES963_20815	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ES963_20820	COG4988	ABC transporter
ES963_20825	COG1294	oxidase, subunit
ES963_20830	COG1271	oxidase subunit
ES963_20835	COG3493	citrate carrier protein
ES963_20840	COG0501	Belongs to the peptidase M48B family
ES963_20850	COG0726	polysaccharide deacetylase
ES963_20855	COG3842	ATPase activity
ES963_20860	COG2508	Transcriptional regulator
ES963_20865	COG1012	belongs to the aldehyde dehydrogenase family
ES963_20870	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES963_20880	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ES963_20890	COG4585	Histidine kinase
ES963_20895	COG2197	response regulator
ES963_20900	COG2195	Cleaves the N-terminal amino acid of tripeptides
ES963_20910	COG4894	glucomannan catabolic process
ES963_20915	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ES963_20920	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ES963_20925	COG1028	Short-chain dehydrogenase reductase Sdr
ES963_20930	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ES963_20935	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ES963_20940	COG2610	gluconate transmembrane transporter activity
ES963_20945	COG0500	methyltransferase
ES963_20950	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES963_20965	COG0693	protein deglycase activity
ES963_20965	COG0753	catalase activity
ES963_20970	COG2851	Citrate transporter
ES963_20975	COG2273	Hydrolase Family 16
ES963_20980	COG3711	transcriptional antiterminator
ES963_20990	COG2270	Major facilitator Superfamily
ES963_20995	COG0513	Belongs to the DEAD box helicase family
ES963_21000	COG3401	FG-GAP repeat protein
ES963_21000	COG2755	lipolytic protein G-D-S-L family
ES963_21130	COG0697	spore germination
ES963_21135	COG0589	response to stress
ES963_21140	COG2723	6-phospho-beta-galactosidase activity
ES963_21145	COG1263	PTS System
ES963_21145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES963_21145	COG2190	(PTS) system
ES963_21155	COG5444	nuclease activity
ES963_21165	COG5444	nuclease activity
ES963_21180	COG3507	Belongs to the glycosyl hydrolase 43 family
ES963_21195	COG2986	histidine ammonia-lyase
ES963_21200	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ES963_21205	COG1228	amidohydrolase
ES963_21210	COG0010	Belongs to the arginase family
ES963_21215	COG0833	amino acid
ES963_21220	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ES963_21225	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES963_21230	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ES963_21235	COG2390	Transcriptional regulator
ES963_21245	COG3192	ethanolamine utilization protein
ES963_21250	COG2079	MmgE PrpD family protein
ES963_21260	COG1126	abc transporter atp-binding protein
ES963_21265	COG0765	amino acid transport
ES963_21270	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES963_21285	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
ES963_21290	COG0561	phosphatase activity
ES963_21320	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES963_21325	COG5294	Protein conserved in bacteria
ES963_21330	COG0577	efflux transmembrane transporter activity
ES963_21335	COG1136	(ABC) transporter
ES963_21340	COG2205	protein histidine kinase activity
ES963_21345	COG0745	RESPONSE REGULATOR receiver
ES963_21350	COG0191	fructose-bisphosphate aldolase activity
ES963_21355	COG1082	Xylose isomerase domain protein TIM barrel
ES963_21360	COG1082	Xylose isomerase domain protein TIM barrel
ES963_21365	COG0673	inositol 2-dehydrogenase activity
ES963_21370	COG2814	Major facilitator Superfamily
ES963_21375	COG1082	Xylose isomerase domain protein TIM barrel
ES963_21380	COG3962	Belongs to the TPP enzyme family
ES963_21385	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES963_21395	COG1012	belongs to the aldehyde dehydrogenase family
ES963_21400	COG1349	DNA-binding transcription factor activity
ES963_21405	COG0667	Aldo Keto reductase
ES963_21420	COG2814	Major facilitator Superfamily
ES963_21425	COG0326	Molecular chaperone. Has ATPase activity
ES963_21435	COG1028	Short-chain dehydrogenase reductase Sdr
ES963_21440	COG1309	transcriptional regulator
ES963_21445	COG1012	belongs to the aldehyde dehydrogenase family
ES963_21450	COG1714	RDD family
ES963_21460	COG1714	RDD family
ES963_21465	COG2311	Membrane
ES963_21470	COG1917	Cupin 2, conserved barrel domain protein
ES963_21475	COG1309	transcriptional regulator
ES963_21480	COG1028	Short-chain dehydrogenase reductase Sdr
ES963_21485	COG1846	Transcriptional regulator
ES963_21490	COG1380	Effector of murein hydrolase LrgA
ES963_21495	COG1346	cytolysis
ES963_21500	COG5039	Polysaccharide pyruvyl transferase
ES963_21505	COG1929	Belongs to the glycerate kinase type-1 family
ES963_21510	COG1802	Transcriptional regulator
ES963_21515	COG1070	Carbohydrate kinase
ES963_21520	COG2610	gluconate transmembrane transporter activity
ES963_21525	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ES963_21530	COG0450	alkyl hydroperoxide reductase
ES963_21535	COG3634	alkyl hydroperoxide reductase activity
ES963_21540	COG2723	6-phospho-beta-galactosidase activity
ES963_21555	COG2188	Transcriptional regulator
ES963_21560	COG1074	ATP-dependent DNA helicase activity
ES963_21565	COG0501	Belongs to the peptidase M48B family
ES963_21585	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
ES963_21595	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ES963_21610	COG1063	alcohol dehydrogenase
ES963_21630	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
ES963_21635	COG0456	acetyltransferase
ES963_21640	COG0457	Tetratricopeptide repeat
ES963_21650	COG0010	Belongs to the arginase family
ES963_21655	COG0833	amino acid
ES963_21660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ES963_21680	COG5658	integral membrane protein
ES963_21685	COG0640	Transcriptional regulator
ES963_21690	COG3829	transcription factor binding
ES963_21705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES963_21710	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ES963_21715	COG4853	Protein conserved in bacteria
ES963_21720	COG4863	YycH protein
ES963_21725	COG5002	protein histidine kinase activity
ES963_21730	COG0745	RESPONSE REGULATOR receiver
ES963_21765	COG0305	Participates in initiation and elongation during chromosome replication
ES963_21780	COG3093	addiction module antidote protein HigA
ES963_21785	COG2807	transmembrane transport
ES963_21790	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ES963_21795	COG0359	binds to the 23S rRNA
ES963_21800	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ES963_21805	COG4241	membrane
ES963_21815	COG5577	PFAM Coat F domain
ES963_21820	COG1733	regulation of RNA biosynthetic process
ES963_21825	COG1227	inorganic diphosphatase activity
ES963_21835	COG2271	Major facilitator Superfamily
ES963_21840	COG4978	Transcriptional regulator
ES963_21840	COG0789	Transcriptional regulator
ES963_21850	COG4319	ketosteroid isomerase
ES963_21855	COG1357	PFAM Pentapeptide repeats (8 copies)
ES963_21860	COG2814	Major facilitator Superfamily
ES963_21865	COG0583	DNA-binding transcription factor activity
ES963_21870	COG2153	protein acetylation
ES963_21885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES963_21890	COG1846	Transcriptional regulator
ES963_21895	COG2153	protein acetylation
ES963_21900	COG2364	Membrane
ES963_21905	COG0456	acetyltransferase
ES963_21910	COG2315	Protein conserved in bacteria
ES963_21915	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ES963_21920	COG1331	Highly conserved protein containing a thioredoxin domain
ES963_21925	COG1266	CAAX protease self-immunity
ES963_21930	COG0477	Major facilitator Superfamily
ES963_21930	COG2814	Major facilitator Superfamily
ES963_21935	COG0110	maltose O-acetyltransferase activity
ES963_21940	COG0346	lactoylglutathione lyase activity
ES963_21945	COG1609	Transcriptional regulator
ES963_21950	COG0708	Exodeoxyribonuclease III
ES963_21955	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ES963_21960	COG0629	single-stranded DNA binding
ES963_21965	COG0360	Binds together with S18 to 16S ribosomal RNA
ES963_21970	COG0012	GTP binding
ES963_21975	COG0243	molybdopterin cofactor binding
ES963_21980	COG4481	Protein conserved in bacteria
ES963_21985	COG3949	Membrane
ES963_21995	COG1475	DNA binding
ES963_22000	COG1192	Involved in chromosome partitioning
ES963_22010	COG1475	DNA binding
ES963_22015	COG0357	Ribosomal RNA small subunit methyltransferase G
ES963_22020	COG0445	tRNA wobble uridine modification
ES963_22025	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ES963_22030	COG1847	R3H domain protein
ES963_22035	COG0706	membrane insertase activity
ES963_22040	COG0594	ribonuclease P activity
ES963_22045	COG0230	Belongs to the bacterial ribosomal protein bL34 family