locus-tag	class	description
ES965_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ES965_00010	COG0592	DNA-directed DNA polymerase activity
ES965_00015	COG2501	S4 domain
ES965_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ES965_00030	COG0187	DNA topoisomerase II activity
ES965_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ES965_00070	COG0516	GMP reductase activity
ES965_00070	COG0517	IMP dehydrogenase activity
ES965_00075	COG1686	Belongs to the peptidase S11 family
ES965_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ES965_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ES965_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ES965_00100	COG1428	Deoxynucleoside kinase
ES965_00105	COG1428	Deoxynucleoside kinase
ES965_00110	COG3858	chitin binding
ES965_00110	COG1388	LysM domain
ES965_00115	COG1335	isochorismatase
ES965_00120	COG0590	tRNA wobble adenosine to inosine editing
ES965_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ES965_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ES965_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ES965_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
ES965_00190	COG3853	Toxic anion resistance protein (TelA)
ES965_00195	COG1982	Orn Lys Arg decarboxylase major
ES965_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ES965_00205	COG3870	Protein conserved in bacteria
ES965_00210	COG1728	Protein conserved in bacteria
ES965_00215	COG0470	DNA polymerase III
ES965_00220	COG1774	PSP1 C-terminal conserved region
ES965_00225	COG4467	Involved in initiation control of chromosome replication
ES965_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ES965_00235	COG2827	Endonuclease containing a URI domain
ES965_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ES965_00245	COG2002	toxin-antitoxin pair type II binding
ES965_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES965_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES965_00255	COG0084	hydrolase, TatD family'
ES965_00260	COG3584	3D domain protein
ES965_00260	COG3583	domain protein
ES965_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ES965_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ES965_00280	COG4466	Protein conserved in bacteria
ES965_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ES965_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ES965_00300	COG0251	oxidation-reduction process
ES965_00305	COG2088	sporulation resulting in formation of a cellular spore
ES965_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ES965_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ES965_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ES965_00325	COG0193	aminoacyl-tRNA hydrolase activity
ES965_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ES965_00340	COG2002	toxin-antitoxin pair type II binding
ES965_00345	COG2244	polysaccharide biosynthetic process
ES965_00350	COG3956	TIGRFAM MazG family protein
ES965_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ES965_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ES965_00375	COG1098	S1 RNA binding domain
ES965_00390	COG2208	phosphoserine phosphatase activity
ES965_00395	COG2304	oxidoreductase activity
ES965_00400	COG0515	serine threonine protein kinase
ES965_00405	COG0037	tRNA processing
ES965_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ES965_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ES965_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ES965_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ES965_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES965_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ES965_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
ES965_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES965_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ES965_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ES965_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ES965_00470	COG1396	sequence-specific DNA binding
ES965_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ES965_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ES965_00560	COG4463	regulation of RNA biosynthetic process
ES965_00565	COG3880	PFAM UvrB UvrC protein
ES965_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
ES965_00575	COG0542	response to heat
ES965_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ES965_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ES965_00590	COG4956	integral membrane protein (PIN domain superfamily)
ES965_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ES965_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ES965_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ES965_00615	COG1045	serine acetyltransferase
ES965_00620	COG0215	cysteine-tRNA ligase activity
ES965_00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ES965_00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ES965_00635	COG3688	RNA-binding protein containing a PIN domain
ES965_00640	COG1595	DNA-templated transcription, initiation
ES965_00645	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ES965_00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ES965_00655	COG0250	Participates in transcription elongation, termination and antitermination
ES965_00660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ES965_00665	COG0081	regulation of translation
ES965_00670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ES965_00675	COG0222	ribosome binding
ES965_00680	COG2813	Specifically methylates the guanine in position
ES965_00685	COG0085	RNA polymerase activity
ES965_00690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ES965_00695	COG1358	cellular component organization or biogenesis
ES965_00700	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ES965_00705	COG0049	tRNA binding
ES965_00710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ES965_00715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ES965_00720	COG0596	Alpha beta hydrolase
ES965_00725	COG0051	transcription antitermination factor activity, RNA binding
ES965_00730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ES965_00735	COG0088	Forms part of the polypeptide exit tunnel
ES965_00740	COG0089	rRNA binding
ES965_00745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ES965_00750	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ES965_00755	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ES965_00760	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ES965_00765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ES965_00770	COG0255	Belongs to the universal ribosomal protein uL29 family
ES965_00775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ES965_00780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ES965_00790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ES965_00800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ES965_00805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ES965_00810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ES965_00815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ES965_00820	COG1841	ribosomal large subunit assembly
ES965_00825	COG0200	Binds to the 23S rRNA
ES965_00830	COG0201	protein transport
ES965_00835	COG0563	adenylate kinase activity
ES965_00840	COG0024	Methionine aminopeptidase
ES965_00845	COG2163	COG2163 Ribosomal protein L14E L6E L27E
ES965_00850	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ES965_00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ES965_00860	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ES965_00865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ES965_00870	COG0202	RNA polymerase activity
ES965_00875	COG0203	ribosomal protein L17
ES965_00880	COG1122	ATPase activity
ES965_00885	COG1122	ATPase activity
ES965_00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ES965_00895	COG0101	tRNA pseudouridine synthase activity
ES965_00900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ES965_00905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ES965_00910	COG2226	methyltransferase
ES965_00920	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES965_00925	COG0489	protein tyrosine kinase activity
ES965_00935	COG2194	sulfuric ester hydrolase activity
ES965_00940	COG0726	polysaccharide deacetylase
ES965_01025	COG0659	secondary active sulfate transmembrane transporter activity
ES965_01030	COG0385	Bile acid
ES965_01035	COG2819	hydrolase of the alpha beta superfamily
ES965_01040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES965_01045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES965_01050	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES965_01055	COG2207	Transcriptional regulator
ES965_01055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES965_01060	COG3876	Protein conserved in bacteria
ES965_01065	COG1472	Belongs to the glycosyl hydrolase 3 family
ES965_01070	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ES965_01075	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES965_01075	COG1263	PTS System
ES965_01080	COG1737	Transcriptional regulator
ES965_01085	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ES965_01090	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES965_01095	COG1683	Conserved Protein
ES965_01125	COG1595	DNA-templated transcription, initiation
ES965_01130	COG5662	AntiSigma factor
ES965_01135	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ES965_01140	COG4856	YbbR-like protein
ES965_01145	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ES965_01150	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ES965_01160	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ES965_01165	COG2169	Transcriptional regulator
ES965_01170	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ES965_01175	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ES965_01180	COG3002	Belongs to the UPF0753 family
ES965_01185	COG0288	reversible hydration of carbon dioxide
ES965_01195	COG5609	conserved protein (DUF2294)
ES965_01200	COG0640	Transcriptional regulator
ES965_01205	COG2814	Major facilitator Superfamily
ES965_01220	COG0596	Alpha beta hydrolase
ES965_01225	COG0745	RESPONSE REGULATOR receiver
ES965_01230	COG0642	Histidine kinase
ES965_01240	COG0515	serine threonine protein kinase
ES965_01255	COG1113	amino acid transport
ES965_01275	COG2124	cytochrome p450
ES965_01285	COG0531	amino acid
ES965_01290	COG0584	glycerophosphoryl diester phosphodiesterase
ES965_01295	COG2271	Major facilitator Superfamily
ES965_01310	COG1846	Transcriptional regulator
ES965_01310	COG0456	acetyltransferase
ES965_01315	COG2271	Major facilitator Superfamily
ES965_01325	COG3409	Peptidoglycan-binding domain 1 protein
ES965_01330	COG0697	spore germination
ES965_01335	COG1917	Cupin 2, conserved barrel domain protein
ES965_01335	COG2207	Transcriptional regulator
ES965_01340	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ES965_01345	COG3591	Belongs to the peptidase S1B family
ES965_01355	COG0596	Alpha beta hydrolase
ES965_01360	COG1183	phosphatidylcholine synthase activity
ES965_01365	COG0586	Pfam SNARE associated Golgi protein
ES965_01370	COG0688	phosphatidylethanolamine metabolic process
ES965_01380	COG2312	Erythromycin esterase
ES965_01390	COG1301	dicarboxylic acid transport
ES965_01395	COG1263	PTS System
ES965_01395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES965_01395	COG2190	(PTS) system
ES965_01400	COG0363	glucosamine-6-phosphate deaminase activity
ES965_01415	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES965_01420	COG0833	amino acid
ES965_01425	COG2040	homocysteine
ES965_01435	COG1115	amino acid carrier protein
ES965_01440	COG2066	Belongs to the glutaminase family
ES965_01445	COG4191	Histidine kinase
ES965_01450	COG0784	Response regulator, receiver
ES965_01460	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ES965_01465	COG1012	belongs to the aldehyde dehydrogenase family
ES965_01470	COG2271	Major facilitator Superfamily
ES965_01475	COG4948	Mandelate Racemase Muconate Lactonizing
ES965_01480	COG2186	Transcriptional regulator
ES965_01485	COG2721	sulfolactate sulfo-lyase activity
ES965_01490	COG3173	Aminoglycoside phosphotransferase
ES965_01505	COG0745	RESPONSE REGULATOR receiver
ES965_01510	COG2205	protein histidine kinase activity
ES965_01515	COG1131	(ABC) transporter
ES965_01535	COG3773	Cell wall hydrolase
ES965_01540	COG2304	oxidoreductase activity
ES965_01550	COG3540	Alkaline phosphatase
ES965_01555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ES965_01560	COG0805	protein transport
ES965_01565	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ES965_01570	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ES965_01575	COG0477	Major facilitator Superfamily
ES965_01580	COG1309	transcriptional regulator
ES965_01585	COG0252	asparaginase activity
ES965_01595	COG1714	RDD family
ES965_01600	COG1405	negative regulation of cell septum assembly
ES965_01600	COG3012	SEC-C Motif Domain Protein
ES965_01605	COG3290	protein histidine kinase activity
ES965_01610	COG3279	Response regulator of the LytR AlgR family
ES965_01615	COG4555	ABC transporter
ES965_01620	COG1668	transmembrane transport
ES965_01625	COG0667	Aldo Keto reductase
ES965_01640	COG1595	DNA-templated transcription, initiation
ES965_01645	COG1595	DNA-templated transcription, initiation
ES965_01650	COG1876	peptidase activity
ES965_01655	COG0457	Tetratricopeptide repeat
ES965_01660	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_01665	COG0366	Alpha amylase catalytic
ES965_01670	COG0803	Belongs to the bacterial solute-binding protein 9 family
ES965_01675	COG1121	(ABC) transporter
ES965_01680	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES965_01685	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES965_01690	COG2310	stress, protein
ES965_01695	COG2310	stress, protein
ES965_01700	COG2310	stress, protein
ES965_01705	COG0861	Integral membrane protein TerC family
ES965_01715	COG3853	Toxic anion resistance protein (TelA)
ES965_01720	COG0477	Major facilitator Superfamily
ES965_01730	COG2814	Major facilitator Superfamily
ES965_01735	COG0640	Transcriptional regulator
ES965_01740	COG0517	IMP dehydrogenase activity
ES965_01740	COG4175	Glycine betaine
ES965_01745	COG4176	ABC-type proline glycine betaine transport system permease component
ES965_01750	COG2113	Glycine betaine
ES965_01755	COG1473	amidohydrolase
ES965_01760	COG1288	antiporter activity
ES965_01770	COG0366	Alpha amylase catalytic
ES965_01775	COG0039	L-malate dehydrogenase activity
ES965_01780	COG1620	l-lactate permease
ES965_01785	COG2814	Major facilitator Superfamily
ES965_01790	COG1846	Transcriptional regulator
ES965_01795	COG1280	lysine exporter protein (LysE YggA)
ES965_01800	COG3403	YqcI/YcgG family
ES965_01805	COG1113	amino acid transport
ES965_01810	COG3665	Urea carboxylase-associated protein
ES965_01815	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ES965_01820	COG1660	Displays ATPase and GTPase activities
ES965_01825	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ES965_01830	COG2226	methyltransferase
ES965_01835	COG0583	DNA-binding transcription factor activity
ES965_01840	COG3458	cephalosporin-C deacetylase activity
ES965_01845	COG3541	Predicted nucleotidyltransferase
ES965_01850	COG0506	proline dehydrogenase activity
ES965_01855	COG1012	belongs to the aldehyde dehydrogenase family
ES965_01860	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES965_01865	COG2508	Transcriptional regulator
ES965_01870	COG3689	TIGRFAM TIGR03943 family protein
ES965_01875	COG0701	Predicted permease
ES965_01880	COG2267	carboxylic ester hydrolase activity
ES965_01885	COG0492	ferredoxin-NADP+ reductase activity
ES965_01890	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ES965_01890	COG1587	Uroporphyrinogen-III synthase
ES965_01895	COG2146	nitrite reductase [NAD(P)H] activity
ES965_01900	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ES965_01905	COG0243	molybdopterin cofactor binding
ES965_01910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ES965_01915	COG2223	nitrite transmembrane transporter activity
ES965_01920	COG1469	GTP cyclohydrolase I activity
ES965_01925	COG1376	ErfK ybiS ycfS ynhG family protein
ES965_01935	COG0523	cobalamin synthesis protein
ES965_01940	COG0765	amino acid transport
ES965_01945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES965_01955	COG1714	RDD family
ES965_01965	COG2723	6-phospho-beta-galactosidase activity
ES965_01975	COG3209	COG3209 Rhs family protein
ES965_01980	COG3290	protein histidine kinase activity
ES965_01980	COG0840	transmembrane signaling receptor activity
ES965_01985	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ES965_01990	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ES965_01995	COG1733	regulation of RNA biosynthetic process
ES965_02000	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_02005	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_02010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_02015	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
ES965_02020	COG2814	Major facilitator Superfamily
ES965_02030	COG0697	spore germination
ES965_02035	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES965_02045	COG2364	Membrane
ES965_02050	COG1126	abc transporter atp-binding protein
ES965_02055	COG0765	amino acid transport
ES965_02060	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES965_02065	COG0583	DNA-binding transcription factor activity
ES965_02070	COG0163	prenyltransferase activity
ES965_02075	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
ES965_02090	COG0596	Alpha beta hydrolase
ES965_02095	COG3104	oligopeptide transport
ES965_02100	COG5434	Belongs to the glycosyl hydrolase 28 family
ES965_02110	COG0697	spore germination
ES965_02120	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ES965_02125	COG1136	(ABC) transporter
ES965_02130	COG0577	efflux transmembrane transporter activity
ES965_02135	COG0745	RESPONSE REGULATOR receiver
ES965_02140	COG3850	Histidine kinase
ES965_02140	COG5002	protein histidine kinase activity
ES965_02145	COG0457	Tetratricopeptide repeat
ES965_02165	COG0527	aspartate kinase activity
ES965_02170	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES965_02175	COG4605	iron ion homeostasis
ES965_02180	COG4604	ABC transporter, ATP-binding protein
ES965_02185	COG4607	ABC-type enterochelin transport system periplasmic component
ES965_02190	COG2814	Major facilitator Superfamily
ES965_02195	COG1309	transcriptional regulator
ES965_02200	COG0778	Nitroreductase
ES965_02205	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ES965_02210	COG0640	Transcriptional regulator
ES965_02215	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES965_02220	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ES965_02225	COG1012	belongs to the aldehyde dehydrogenase family
ES965_02230	COG4975	Glucose uptake
ES965_02235	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_02240	COG4549	nuclear export factor GLE1
ES965_02245	COG2372	response to copper ion
ES965_02245	COG1276	copper resistance
ES965_02250	COG1349	DNA-binding transcription factor activity
ES965_02260	COG2213	PTS system mannitol-specific
ES965_02265	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES965_02270	COG0246	Mannitol dehydrogenase
ES965_02275	COG0473	3-isopropylmalate dehydrogenase activity
ES965_02280	COG0681	Belongs to the peptidase S26 family
ES965_02285	COG0412	Dienelactone hydrolase
ES965_02290	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ES965_02300	COG0561	phosphatase activity
ES965_02305	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ES965_02310	COG1914	H( )-stimulated, divalent metal cation uptake system
ES965_02315	COG4336	lyase activity
ES965_02320	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ES965_02325	COG1984	allophanate hydrolase subunit 2
ES965_02330	COG1414	Transcriptional regulator
ES965_02335	COG2755	lipolytic protein G-D-S-L family
ES965_02345	COG2329	Antibiotic biosynthesis monooxygenase
ES965_02350	COG0768	penicillin binding
ES965_02355	COG4989	oxidoreductase activity
ES965_02360	COG3711	transcriptional antiterminator
ES965_02365	COG0318	PFAM AMP-dependent synthetase and ligase
ES965_02370	COG2226	methyltransferase
ES965_02375	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_02380	COG1917	Cupin 2, conserved barrel domain protein
ES965_02385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES965_02390	COG3871	stress protein (general stress protein 26)
ES965_02400	COG2814	Major facilitator Superfamily
ES965_02405	COG1522	sequence-specific DNA binding
ES965_02410	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ES965_02410	COG0551	DNA topoisomerase type I activity
ES965_02415	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
ES965_02420	COG3706	GGDEF domain
ES965_02425	COG5298	Protein conserved in bacteria
ES965_02430	COG1215	transferase activity, transferring glycosyl groups
ES965_02440	COG0531	amino acid
ES965_02445	COG0494	nUDIX hydrolase
ES965_02450	COG0028	Belongs to the TPP enzyme family
ES965_02465	COG1914	H( )-stimulated, divalent metal cation uptake system
ES965_02470	COG2261	transglycosylase associated protein
ES965_02475	COG4876	unkown
ES965_02480	COG2217	Heavy metal translocating P-type atpase
ES965_02485	COG3729	General stress protein
ES965_02490	COG0662	Cupin 2, conserved barrel domain protein
ES965_02495	COG2329	Antibiotic biosynthesis monooxygenase
ES965_02500	COG3546	catalase activity
ES965_02505	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ES965_02510	COG3290	protein histidine kinase activity
ES965_02515	COG4565	transcriptional regulatory protein
ES965_02520	COG1301	dicarboxylic acid transport
ES965_02525	COG0628	permease
ES965_02530	COG1131	(ABC) transporter
ES965_02535	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES965_02545	COG1960	acyl-CoA dehydrogenase activity
ES965_02560	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES965_02565	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES965_02570	COG1181	Belongs to the D-alanine--D-alanine ligase family
ES965_02575	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ES965_02585	COG0513	Belongs to the DEAD box helicase family
ES965_02590	COG3402	PFAM membrane-flanked domain
ES965_02595	COG3428	Bacterial PH domain
ES965_02600	COG0705	Rhomboid family
ES965_02605	COG0736	holo-[acyl-carrier-protein] synthase activity
ES965_02610	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ES965_02615	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ES965_02620	COG0864	Transcriptional regulator
ES965_02625	COG2337	Toxic component of a toxin-antitoxin (TA) module
ES965_02630	COG1366	Belongs to the anti-sigma-factor antagonist family
ES965_02635	COG1366	Belongs to the anti-sigma-factor antagonist family
ES965_02640	COG2172	sigma factor antagonist activity
ES965_02645	COG2208	phosphoserine phosphatase activity
ES965_02650	COG1366	Belongs to the anti-sigma-factor antagonist family
ES965_02655	COG2172	sigma factor antagonist activity
ES965_02660	COG1191	sigma factor activity
ES965_02665	COG2208	phosphoserine phosphatase activity
ES965_02670	COG2183	response to ionizing radiation
ES965_02680	COG3091	SprT-like family
ES965_02730	COG0515	serine threonine protein kinase
ES965_02735	COG0515	serine threonine protein kinase
ES965_02740	COG1132	(ABC) transporter
ES965_02755	COG1476	TRANSCRIPTIONal
ES965_02765	COG3239	Fatty acid desaturase
ES965_02775	COG1278	Cold shock
ES965_02780	COG1329	Transcriptional regulator
ES965_02790	COG0697	spore germination
ES965_02795	COG1917	Cupin 2, conserved barrel domain protein
ES965_02795	COG2207	Transcriptional regulator
ES965_02800	COG0697	spore germination
ES965_02805	COG2207	Transcriptional regulator
ES965_02805	COG3708	Transcriptional regulator
ES965_02810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES965_02815	COG0477	Major facilitator Superfamily
ES965_02825	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
ES965_02845	COG1309	transcriptional regulator
ES965_02850	COG0697	spore germination
ES965_02855	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES965_02860	COG2030	dehydratase
ES965_02865	COG3545	Serine hydrolase
ES965_02870	COG1733	regulation of RNA biosynthetic process
ES965_02875	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES965_02880	COG1733	regulation of RNA biosynthetic process
ES965_02885	COG2249	NAD(P)H dehydrogenase (quinone) activity
ES965_02890	COG2814	Major facilitator Superfamily
ES965_02895	COG1309	transcriptional regulator
ES965_02900	COG0640	Transcriptional regulator
ES965_02905	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ES965_02915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES965_02925	COG0726	polysaccharide deacetylase
ES965_02935	COG5002	protein histidine kinase activity
ES965_02940	COG0745	RESPONSE REGULATOR receiver
ES965_02945	COG0697	spore germination
ES965_02950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES965_02955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ES965_02960	COG0640	Transcriptional regulator
ES965_02965	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ES965_02980	COG4585	Histidine kinase
ES965_02985	COG2197	response regulator
ES965_02990	COG2409	Drug exporters of the RND superfamily
ES965_02995	COG0596	Alpha beta hydrolase
ES965_03000	COG1811	Na channel or pump
ES965_03005	COG4978	Transcriptional regulator
ES965_03005	COG0789	Transcriptional regulator
ES965_03010	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES965_03020	COG0346	lactoylglutathione lyase activity
ES965_03025	COG2259	Doxx family
ES965_03030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES965_03045	COG2323	membrane
ES965_03050	COG2323	membrane
ES965_03055	COG0071	Belongs to the small heat shock protein (HSP20) family
ES965_03070	COG1309	transcriptional regulator
ES965_03080	COG0456	acetyltransferase
ES965_03090	COG1113	amino acid transport
ES965_03095	COG2318	DinB family
ES965_03100	COG1846	Transcriptional regulator
ES965_03105	COG1033	growth of symbiont in host cell
ES965_03105	COG2409	Drug exporters of the RND superfamily
ES965_03110	COG0778	Nitroreductase
ES965_03115	COG1846	Transcriptional regulator
ES965_03120	COG2814	Major facilitator Superfamily
ES965_03125	COG0730	response to heat
ES965_03130	COG1802	Transcriptional regulator
ES965_03135	COG1388	LysM domain
ES965_03135	COG3858	chitin binding
ES965_03140	COG1819	glycosyl
ES965_03150	COG1785	Belongs to the alkaline phosphatase family
ES965_03155	COG5646	InterPro IPR014922
ES965_03165	COG0454	-acetyltransferase
ES965_03170	COG1078	dGTPase activity
ES965_03175	COG1388	LysM domain
ES965_03180	COG2814	Major facilitator Superfamily
ES965_03185	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES965_03190	COG1447	Phosphotransferase system cellobiose-specific component IIA
ES965_03195	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES965_03200	COG2723	6-phospho-beta-galactosidase activity
ES965_03205	COG2188	Transcriptional regulator
ES965_03210	COG1940	carbohydrate kinase activity
ES965_03215	COG1482	cell wall glycoprotein biosynthetic process
ES965_03220	COG4124	Belongs to the glycosyl hydrolase 26 family
ES965_03265	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ES965_03270	COG0802	atpase or kinase
ES965_03275	COG1214	PFAM Peptidase M22, glycoprotease
ES965_03280	COG0456	acetyltransferase
ES965_03285	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ES965_03290	COG0488	(ABC) transporter
ES965_03295	COG0315	cyclic pyranopterin monophosphate synthase activity
ES965_03300	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ES965_03305	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ES965_03310	COG0805	protein transport
ES965_03325	COG1266	CAAX protease self-immunity
ES965_03330	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ES965_03335	COG0459	protein refolding
ES965_03360	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ES965_03365	COG0457	Tetratricopeptide repeat
ES965_03370	COG1063	alcohol dehydrogenase
ES965_03375	COG2211	Major facilitator Superfamily
ES965_03380	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES965_03385	COG1842	Phage shock protein A
ES965_03390	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ES965_03395	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ES965_03400	COG4260	virion core protein, lumpy skin disease virus
ES965_03410	COG2814	Major facilitator Superfamily
ES965_03415	COG1063	alcohol dehydrogenase
ES965_03420	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ES965_03425	COG0823	Involved in the tonB-independent uptake of proteins
ES965_03440	COG2267	carboxylic ester hydrolase activity
ES965_03450	COG2132	Multicopper oxidase
ES965_03455	COG1113	amino acid transport
ES965_03465	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES965_03470	COG0714	Associated with various cellular activities
ES965_03475	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
ES965_03480	COG1305	Transglutaminase-like
ES965_03485	COG0519	Catalyzes the synthesis of GMP from XMP
ES965_03485	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ES965_03500	COG2252	PERMEase
ES965_03505	COG3064	Membrane
ES965_03515	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
ES965_03525	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ES965_03530	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ES965_03535	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ES965_03540	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ES965_03545	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ES965_03550	COG0047	phosphoribosylformylglycinamidine synthase activity
ES965_03555	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ES965_03560	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ES965_03565	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ES965_03570	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ES965_03575	COG0138	bifunctional purine biosynthesis protein purh
ES965_03580	COG0151	Belongs to the GarS family
ES965_03585	COG1522	sequence-specific DNA binding
ES965_03590	COG0531	amino acid
ES965_03600	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ES965_03605	COG1470	cell adhesion involved in biofilm formation
ES965_03610	COG4496	protein, YerC YecD
ES965_03615	COG0069	glutamate synthase activity
ES965_03620	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ES965_03625	COG0210	DNA helicase
ES965_03630	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ES965_03635	COG4851	CamS sex pheromone cAM373 precursor
ES965_03640	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES965_03645	COG1285	pathogenesis
ES965_03650	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES965_03655	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ES965_03660	COG0154	amidase activity
ES965_03665	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ES965_03670	COG1309	transcriptional regulator
ES965_03675	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ES965_03680	COG1597	lipid kinase activity
ES965_03685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ES965_03710	COG0457	Tetratricopeptide repeat
ES965_03725	COG5444	nuclease activity
ES965_03730	COG3391	amine dehydrogenase activity
ES965_03740	COG0457	Tetratricopeptide repeat
ES965_03750	COG0217	transcriptional regulatory protein
ES965_03760	COG1309	transcriptional regulator
ES965_03765	COG3631	Ketosteroid isomerase-related protein
ES965_03785	COG3546	catalase activity
ES965_03790	COG0454	-acetyltransferase
ES965_03800	COG5578	integral membrane protein
ES965_03805	COG2972	Histidine kinase
ES965_03810	COG4753	response regulator
ES965_03810	COG2207	Transcriptional regulator
ES965_03815	COG1653	transport
ES965_03820	COG1175	transmembrane transport
ES965_03825	COG0395	ABC-type sugar transport system, permease component
ES965_03830	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ES965_03835	COG2207	Transcriptional regulator
ES965_03840	COG2755	lipolytic protein G-D-S-L family
ES965_03850	COG5578	integral membrane protein
ES965_03855	COG3401	FG-GAP repeat protein
ES965_03860	COG3401	FG-GAP repeat protein
ES965_03865	COG2755	lipolytic protein G-D-S-L family
ES965_03870	COG1874	Beta-galactosidase
ES965_03880	COG1653	transport
ES965_03885	COG4209	transmembrane transport
ES965_03890	COG0395	ABC-type sugar transport system, permease component
ES965_03895	COG1486	melibiose metabolic process
ES965_03900	COG2323	membrane
ES965_03905	COG2329	Antibiotic biosynthesis monooxygenase
ES965_03910	COG0346	lactoylglutathione lyase activity
ES965_03925	COG5583	Uncharacterized small protein (DUF2292)
ES965_03930	COG0670	Belongs to the BI1 family
ES965_03945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ES965_03955	COG2124	cytochrome p450
ES965_03955	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ES965_03970	COG1368	sulfuric ester hydrolase activity
ES965_03975	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ES965_03980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES965_03985	COG1442	glycosyl transferase family 8
ES965_03990	COG1216	Glycosyl transferase, family 2
ES965_03995	COG1442	glycosyl transferase family 8
ES965_04000	COG2223	nitrite transmembrane transporter activity
ES965_04010	COG0531	amino acid
ES965_04015	COG1012	belongs to the aldehyde dehydrogenase family
ES965_04020	COG0840	transmembrane signaling receptor activity
ES965_04025	COG0488	(ABC) transporter
ES965_04035	COG0789	Transcriptional regulator
ES965_04040	COG2814	Major facilitator Superfamily
ES965_04055	COG0488	(ABC) transporter
ES965_04060	COG0513	Belongs to the DEAD box helicase family
ES965_04065	COG0456	acetyltransferase
ES965_04070	COG2130	NADP-dependent
ES965_04075	COG1120	ATPase activity
ES965_04080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES965_04085	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES965_04090	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ES965_04110	COG3866	Pectate lyase
ES965_04115	COG0471	metal ion transport
ES965_04120	COG3290	protein histidine kinase activity
ES965_04125	COG4565	transcriptional regulatory protein
ES965_04130	COG3181	Tripartite tricarboxylate transporter family receptor
ES965_04135	COG2851	Citrate transporter
ES965_04140	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES965_04145	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
ES965_04150	COG1254	Belongs to the acylphosphatase family
ES965_04155	COG2258	MOSC domain
ES965_04175	COG0024	Methionine aminopeptidase
ES965_04180	COG1263	PTS System
ES965_04180	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES965_04185	COG1368	sulfuric ester hydrolase activity
ES965_04200	COG1115	amino acid carrier protein
ES965_04215	COG0697	spore germination
ES965_04220	COG1263	PTS System
ES965_04220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES965_04225	COG0366	Alpha amylase catalytic
ES965_04230	COG2188	Transcriptional regulator
ES965_04235	COG0778	Nitroreductase
ES965_04240	COG0737	Belongs to the 5'-nucleotidase family
ES965_04245	COG0693	protein deglycase activity
ES965_04250	COG2814	Major facilitator Superfamily
ES965_04255	COG4840	Belongs to the UPF0435 family
ES965_04260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ES965_04265	COG4980	gas vesicle protein
ES965_04270	COG1295	ribonuclease BN
ES965_04275	COG0477	Major facilitator Superfamily
ES965_04280	COG0387	Pfam Sodium calcium exchanger
ES965_04290	COG0668	transmembrane transport
ES965_04295	COG0535	radical SAM domain protein
ES965_04305	COG0726	polysaccharide deacetylase
ES965_04310	COG2084	Dehydrogenase
ES965_04315	COG0598	Magnesium transport protein CorA
ES965_04320	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ES965_04325	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ES965_04340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ES965_04345	COG4637	Psort location Cytoplasmic, score
ES965_04355	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES965_04360	COG0022	dehydrogenase e1 component
ES965_04365	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES965_04370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES965_04375	COG3284	Transcriptional regulator
ES965_04385	COG1742	UPF0060 membrane protein
ES965_04405	COG4842	Belongs to the WXG100 family
ES965_04410	COG1486	melibiose metabolic process
ES965_04415	COG1737	Transcriptional regulator
ES965_04420	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES965_04420	COG1263	PTS System
ES965_04425	COG5434	Belongs to the glycosyl hydrolase 28 family
ES965_04430	COG1132	(ABC) transporter
ES965_04435	COG1132	(ABC) transporter
ES965_04440	COG2259	Doxx family
ES965_04445	COG2514	catechol 2,3-dioxygenase activity
ES965_04450	COG4977	sequence-specific DNA binding
ES965_04450	COG1917	Cupin 2, conserved barrel domain protein
ES965_04460	COG1082	Xylose isomerase domain protein TIM barrel
ES965_04465	COG0673	inositol 2-dehydrogenase activity
ES965_04470	COG4585	Histidine kinase
ES965_04475	COG2197	response regulator
ES965_04480	COG1131	(ABC) transporter
ES965_04485	COG0842	Transport permease protein
ES965_04485	COG1511	domain protein
ES965_04490	COG0842	Transport permease protein
ES965_04500	COG1695	Transcriptional regulator
ES965_04505	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ES965_04510	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
ES965_04515	COG1309	transcriptional regulator
ES965_04520	COG2814	Major facilitator Superfamily
ES965_04525	COG2318	DinB family
ES965_04530	COG2814	Major facilitator Superfamily
ES965_04535	COG1846	Transcriptional regulator
ES965_04540	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ES965_04540	COG0392	lysyltransferase activity
ES965_04545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES965_04550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES965_04555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES965_04560	COG0384	phenazine biosynthesis protein PhzF
ES965_04565	COG0778	Nitroreductase
ES965_04580	COG1090	epimerase
ES965_04585	COG2137	regulation of response to DNA damage stimulus
ES965_04600	COG2814	Major facilitator Superfamily
ES965_04615	COG3103	Sh3 type 3 domain protein
ES965_04620	COG5658	integral membrane protein
ES965_04625	COG0596	Alpha beta hydrolase
ES965_04630	COG0463	Glycosyl transferase, family 2
ES965_04635	COG4485	Bacterial membrane protein, YfhO
ES965_04640	COG1988	membrane-bound metal-dependent
ES965_04645	COG1194	a g-specific adenine glycosylase
ES965_04655	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_04670	COG3557	Belongs to the UPF0374 family
ES965_04675	COG1132	(ABC) transporter
ES965_04680	COG4129	membrane
ES965_04685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ES965_04690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ES965_04695	COG0735	belongs to the Fur family
ES965_04805	COG4326	sporulation control protein
ES965_04815	COG5577	PFAM Coat F domain
ES965_04820	COG3340	Belongs to the peptidase S51 family
ES965_04825	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ES965_04830	COG0277	FAD linked oxidase domain protein
ES965_04840	COG0753	catalase activity
ES965_04845	COG1116	anion transmembrane transporter activity
ES965_04850	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ES965_04855	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ES965_04860	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES965_04870	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ES965_04880	COG1476	TRANSCRIPTIONal
ES965_04890	COG3382	B3 4 domain protein
ES965_04895	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ES965_04905	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ES965_04910	COG0789	Transcriptional regulator
ES965_04915	COG1664	Polymer-forming cytoskeletal
ES965_04920	COG1664	Polymer-forming cytoskeletal
ES965_04925	COG2766	serine protein kinase
ES965_04930	COG2718	Belongs to the UPF0229 family
ES965_04935	COG1846	Transcriptional regulator
ES965_04940	COG1566	PFAM secretion protein HlyD family protein
ES965_04945	COG2814	Major facilitator Superfamily
ES965_04950	COG0655	NAD(P)H dehydrogenase (quinone) activity
ES965_04970	COG1725	Transcriptional regulator
ES965_04975	COG1131	(ABC) transporter
ES965_04980	COG1131	(ABC) transporter
ES965_04985	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES965_04990	COG1278	Cold shock
ES965_05000	COG1464	Belongs to the NlpA lipoprotein family
ES965_05005	COG3706	GGDEF domain
ES965_05010	COG1823	symporter activity
ES965_05030	COG5577	PFAM Coat F domain
ES965_05035	COG4085	toxin activity
ES965_05035	COG0737	Belongs to the 5'-nucleotidase family
ES965_05035	COG1525	nuclease
ES965_05040	COG3764	Sortase (surface protein transpeptidase)
ES965_05045	COG0564	pseudouridine synthase activity
ES965_05055	COG0517	IMP dehydrogenase activity
ES965_05060	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ES965_05065	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ES965_05065	COG3153	acetyltransferase
ES965_05070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES965_05075	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ES965_05080	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ES965_05085	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ES965_05090	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ES965_05095	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ES965_05100	COG2203	Gaf domain
ES965_05100	COG4585	Histidine kinase
ES965_05105	COG2197	response regulator
ES965_05110	COG0431	NADPH-dependent FMN reductase
ES965_05125	COG1388	LysM domain
ES965_05125	COG0791	NLP P60 protein
ES965_05130	COG1959	2 iron, 2 sulfur cluster binding
ES965_05135	COG0668	transmembrane transport
ES965_05140	COG2719	SpoVR family
ES965_05145	COG1785	Belongs to the alkaline phosphatase family
ES965_05150	COG1388	LysM domain
ES965_05150	COG0791	NLP P60 protein
ES965_05155	COG0583	DNA-binding transcription factor activity
ES965_05160	COG0372	Belongs to the citrate synthase family
ES965_05165	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_05170	COG0531	amino acid
ES965_05175	COG0733	neurotransmitter:sodium symporter activity
ES965_05180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES965_05185	COG0456	acetyltransferase
ES965_05200	COG1595	DNA-templated transcription, initiation
ES965_05205	COG0667	Aldo Keto reductase
ES965_05210	COG0204	Acyl-transferase
ES965_05215	COG1253	flavin adenine dinucleotide binding
ES965_05220	COG0789	Transcriptional regulator
ES965_05225	COG0436	Aminotransferase
ES965_05230	COG1253	flavin adenine dinucleotide binding
ES965_05235	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ES965_05240	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ES965_05245	COG0584	glycerophosphoryl diester phosphodiesterase
ES965_05255	COG0668	transmembrane transport
ES965_05260	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ES965_05265	COG0726	polysaccharide deacetylase
ES965_05270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES965_05275	COG1757	Na H antiporter
ES965_05280	COG0589	response to stress
ES965_05290	COG1132	(ABC) transporter
ES965_05295	COG1132	(ABC) transporter
ES965_05300	COG0702	epimerase
ES965_05320	COG0189	ligase activity
ES965_05325	COG0189	ligase activity
ES965_05330	COG4399	Belongs to the UPF0754 family
ES965_05335	COG3679	Belongs to the UPF0342 family
ES965_05340	COG4335	DNA alkylation repair
ES965_05345	COG0561	phosphatase activity
ES965_05350	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ES965_05355	COG0475	glutathione-regulated potassium exporter activity
ES965_05360	COG0490	domain, Protein
ES965_05370	COG1024	Enoyl-CoA hydratase
ES965_05380	COG4152	abc transporter atp-binding protein
ES965_05385	COG1668	transmembrane transport
ES965_05390	COG0420	3'-5' exonuclease activity
ES965_05395	COG4717	serine-type aminopeptidase activity
ES965_05400	COG3481	metal-dependent phosphohydrolase, HD sub domain
ES965_05410	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ES965_05440	COG1846	Transcriptional regulator
ES965_05445	COG4980	gas vesicle protein
ES965_05460	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ES965_05465	COG0537	adenosine 5'-monophosphoramidase activity
ES965_05470	COG1131	(ABC) transporter
ES965_05475	COG4473	ABC transporter
ES965_05485	COG1473	amidohydrolase
ES965_05490	COG3069	C4-dicarboxylate transmembrane transporter activity
ES965_05500	COG2329	Antibiotic biosynthesis monooxygenase
ES965_05505	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES965_05510	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ES965_05525	COG1309	transcriptional regulator
ES965_05530	COG1511	domain protein
ES965_05535	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES965_05540	COG4377	Putative membrane peptidase family (DUF2324)
ES965_05550	COG1363	Peptidase, m42
ES965_05555	COG4405	Protein conserved in bacteria
ES965_05560	COG1301	dicarboxylic acid transport
ES965_05570	COG1234	tRNA 3'-trailer cleavage
ES965_05575	COG0095	Lipoate-protein ligase
ES965_05580	COG0702	epimerase
ES965_05585	COG0318	PFAM AMP-dependent synthetase and ligase
ES965_05595	COG0501	Belongs to the peptidase M48B family
ES965_05600	COG1404	Belongs to the peptidase S8 family
ES965_05605	COG0456	acetyltransferase
ES965_05610	COG0604	alcohol dehydrogenase
ES965_05615	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ES965_05620	COG0406	alpha-ribazole phosphatase activity
ES965_05625	COG0183	Belongs to the thiolase family
ES965_05630	COG0318	PFAM AMP-dependent synthetase and ligase
ES965_05635	COG1268	BioY protein
ES965_05640	COG0840	transmembrane signaling receptor activity
ES965_05645	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ES965_05645	COG0723	plastoquinol--plastocyanin reductase activity
ES965_05650	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_05660	COG4903	ComK protein
ES965_05665	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_05675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES965_05690	COG0398	Pfam SNARE associated Golgi protein
ES965_05695	COG0681	Belongs to the peptidase S26 family
ES965_05700	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ES965_05705	COG1846	Transcriptional regulator
ES965_05715	COG0738	Major facilitator superfamily
ES965_05720	COG0673	inositol 2-dehydrogenase activity
ES965_05725	COG0561	phosphatase activity
ES965_05730	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES965_05735	COG1609	Transcriptional regulator
ES965_05740	COG3180	Ammonia monooxygenase
ES965_05745	COG0477	Major facilitator Superfamily
ES965_05745	COG2814	Major facilitator Superfamily
ES965_05750	COG4533	DNA binding
ES965_05760	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ES965_05765	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ES965_05770	COG1074	ATP-dependent DNA helicase activity
ES965_05775	COG0420	3'-5' exonuclease activity
ES965_05780	COG0419	ATPase involved in DNA repair
ES965_05785	COG1403	HNH endonuclease
ES965_05825	COG5337	Spore coat protein CotH
ES965_05830	COG0179	Fumarylacetoacetate (FAA) hydrolase
ES965_05840	COG1404	Belongs to the peptidase S8 family
ES965_05850	COG0367	asparagine synthase
ES965_05855	COG1562	ergosterol biosynthetic process
ES965_05860	COG0534	Mate efflux family protein
ES965_05865	COG2207	Transcriptional regulator
ES965_05865	COG1917	Cupin 2, conserved barrel domain protein
ES965_05870	COG1609	Transcriptional regulator
ES965_05875	COG0673	inositol 2-dehydrogenase activity
ES965_05880	COG2318	DinB family
ES965_05885	COG1279	arginine transmembrane transporter activity
ES965_05890	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES965_05895	COG1357	PFAM Pentapeptide repeats (8 copies)
ES965_05900	COG2267	carboxylic ester hydrolase activity
ES965_05905	COG0529	Catalyzes the synthesis of activated sulfate
ES965_05910	COG2046	Belongs to the sulfate adenylyltransferase family
ES965_05915	COG0175	sulfate reduction
ES965_05920	COG2045	Belongs to the ComB family
ES965_05925	COG1809	phosphosulfolactate synthase activity
ES965_05930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES965_05935	COG4948	Mandelate Racemase Muconate Lactonizing
ES965_05940	COG2814	Major facilitator Superfamily
ES965_05945	COG0454	-acetyltransferase
ES965_05950	COG2153	protein acetylation
ES965_05955	COG0646	methionine synthase
ES965_05955	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ES965_05960	COG1666	GTP binding
ES965_05965	COG2996	Protein conserved in bacteria
ES965_05985	COG1695	Transcriptional regulator
ES965_06000	COG3227	Zinc metalloprotease (Elastase)
ES965_06005	COG1307	EDD domain protein, DegV family
ES965_06010	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES965_06025	COG0561	phosphatase activity
ES965_06030	COG1073	alpha beta
ES965_06035	COG2151	metal-sulfur cluster biosynthetic enzyme
ES965_06045	COG0277	FAD linked oxidase domain protein
ES965_06050	COG2271	Major facilitator Superfamily
ES965_06055	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ES965_06070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ES965_06075	COG0505	Belongs to the CarA family
ES965_06080	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ES965_06085	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ES965_06100	COG2267	carboxylic ester hydrolase activity
ES965_06110	COG1744	ABC transporter substrate-binding protein PnrA-like
ES965_06125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES965_06130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ES965_06135	COG5504	Zn-dependent protease
ES965_06140	COG0444	Belongs to the ABC transporter superfamily
ES965_06145	COG4608	Belongs to the ABC transporter superfamily
ES965_06155	COG0601	transmembrane transport
ES965_06160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES965_06170	COG0180	Tryptophanyl-tRNA synthetase
ES965_06175	COG4166	transmembrane transport
ES965_06180	COG0601	transmembrane transport
ES965_06185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES965_06190	COG0444	Belongs to the ABC transporter superfamily
ES965_06195	COG4608	Belongs to the ABC transporter superfamily
ES965_06200	COG2814	Major facilitator Superfamily
ES965_06205	COG0456	acetyltransferase
ES965_06210	COG1393	Belongs to the ArsC family
ES965_06215	COG0861	Integral membrane protein TerC family
ES965_06225	COG4862	establishment of competence for transformation
ES965_06235	COG4469	Competence protein
ES965_06240	COG1164	Oligoendopeptidase f
ES965_06260	COG2346	COG2346, Truncated hemoglobins
ES965_06265	COG0741	lytic transglycosylase activity
ES965_06270	COG4116	CYTH
ES965_06280	COG2357	RelA SpoT domain protein
ES965_06285	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ES965_06290	COG0564	pseudouridine synthase activity
ES965_06295	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ES965_06300	COG0475	glutathione-regulated potassium exporter activity
ES965_06300	COG0569	domain protein
ES965_06305	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ES965_06310	COG0352	thiamine-phosphate diphosphorylase activity
ES965_06315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ES965_06320	COG2104	thiamine diphosphate biosynthetic process
ES965_06325	COG2022	thiamine diphosphate biosynthetic process
ES965_06330	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ES965_06335	COG0351	phosphomethylpyrimidine kinase
ES965_06340	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ES965_06395	COG0210	DNA helicase
ES965_06425	COG2153	protein acetylation
ES965_06430	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ES965_06435	COG2382	esterase
ES965_06440	COG0626	cystathionine gamma-synthase activity
ES965_06445	COG0626	cystathionine gamma-synthase activity
ES965_06450	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES965_06455	COG5505	Protein of unknown function (DUF819)
ES965_06480	COG0515	serine threonine protein kinase
ES965_06480	COG2815	serine threonine protein kinase
ES965_06490	COG0457	Tetratricopeptide repeat
ES965_06495	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ES965_06500	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_06510	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES965_06510	COG3711	transcriptional antiterminator
ES965_06515	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES965_06515	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES965_06515	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES965_06520	COG1482	cell wall glycoprotein biosynthetic process
ES965_06530	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES965_06540	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ES965_06560	COG0109	protoheme IX farnesyltransferase activity
ES965_06570	COG0726	polysaccharide deacetylase
ES965_06585	COG5504	Zn-dependent protease
ES965_06590	COG2205	protein histidine kinase activity
ES965_06600	COG3383	formate dehydrogenase (NAD+) activity
ES965_06605	COG2427	Protein of unknown function (DUF1641)
ES965_06615	COG1051	belongs to the nudix hydrolase family
ES965_06625	COG2124	cytochrome p450
ES965_06630	COG1819	glycosyl
ES965_06640	COG1587	Uroporphyrinogen-III synthase
ES965_06645	COG0390	transport system, permease component
ES965_06650	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES965_06660	COG4297	protein containing double-stranded beta helix domain
ES965_06670	COG1252	NADH dehydrogenase
ES965_06675	COG1904	glucuronate isomerase
ES965_06680	COG2211	Major facilitator Superfamily
ES965_06685	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
ES965_06690	COG1063	alcohol dehydrogenase
ES965_06695	COG1312	Catalyzes the dehydration of D-mannonate
ES965_06700	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_06705	COG2271	Major facilitator Superfamily
ES965_06710	COG1609	Transcriptional regulator
ES965_06715	COG0246	Mannitol dehydrogenase
ES965_06720	COG2721	sulfolactate sulfo-lyase activity
ES965_06725	COG0730	response to heat
ES965_06730	COG2318	DinB family
ES965_06735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ES965_06740	COG0457	Tetratricopeptide repeat
ES965_06750	COG2350	Protein conserved in bacteria
ES965_06755	COG1388	LysM domain
ES965_06755	COG3409	Peptidoglycan-binding domain 1 protein
ES965_06755	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES965_06765	COG4195	phage-related replication protein
ES965_06770	COG3546	catalase activity
ES965_06775	COG2856	Zn peptidase
ES965_06780	COG1396	sequence-specific DNA binding
ES965_06790	COG1522	sequence-specific DNA binding
ES965_06795	COG1484	DNA-dependent DNA replication
ES965_06815	COG1595	DNA-templated transcription, initiation
ES965_06820	COG3728	DNA packaging
ES965_06820	COG5484	DNA packaging
ES965_06825	COG1783	phage Terminase large subunit
ES965_06830	COG5518	Phage portal protein
ES965_06835	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ES965_06840	COG4653	Phage capsid family
ES965_06890	COG3953	SLT domain
ES965_06890	COG5412	phage tail tape measure protein
ES965_06890	COG3953	SLT domain
ES965_06890	COG5412	phage tail tape measure protein
ES965_06895	COG1652	LysM domain
ES965_06900	COG4193	domain, Protein
ES965_06910	COG3628	GPW Gp25 family protein
ES965_06915	COG3299	homolog of phage Mu protein gp47
ES965_06920	COG3778	Protein conserved in bacteria
ES965_06960	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES965_06960	COG3409	Peptidoglycan-binding domain 1 protein
ES965_06980	COG0306	phosphate transporter
ES965_06985	COG1392	Phosphate transport regulator
ES965_06990	COG0531	amino acid
ES965_06995	COG0346	lactoylglutathione lyase activity
ES965_07005	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ES965_07010	COG0463	Glycosyl transferase, family 2
ES965_07015	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES965_07020	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES965_07025	COG2362	D-Aminopeptidase
ES965_07030	COG0601	transmembrane transport
ES965_07035	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES965_07040	COG0444	Belongs to the ABC transporter superfamily
ES965_07045	COG4166	transmembrane transport
ES965_07050	COG1619	proteins homologs of microcin C7 resistance protein MccF
ES965_07055	COG4948	Mandelate Racemase Muconate Lactonizing
ES965_07060	COG0791	NLP P60 protein
ES965_07065	COG4608	Belongs to the ABC transporter superfamily
ES965_07070	COG2706	6-phosphogluconolactonase activity
ES965_07075	COG1834	amidinotransferase
ES965_07080	COG1607	acyl-coa hydrolase
ES965_07085	COG1017	nitric oxide dioxygenase activity
ES965_07085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ES965_07095	COG2323	membrane
ES965_07100	COG2318	DinB family
ES965_07105	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES965_07110	COG2076	Multidrug Resistance protein
ES965_07115	COG2076	Multidrug Resistance protein
ES965_07120	COG0788	formyltetrahydrofolate deformylase activity
ES965_07125	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ES965_07130	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ES965_07135	COG1764	response to oxidative stress
ES965_07140	COG1846	Transcriptional regulator
ES965_07145	COG1764	response to oxidative stress
ES965_07150	COG0590	tRNA wobble adenosine to inosine editing
ES965_07155	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ES965_07160	COG1404	Belongs to the peptidase S8 family
ES965_07165	COG1366	Belongs to the anti-sigma-factor antagonist family
ES965_07170	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ES965_07175	COG1122	ATPase activity
ES965_07180	COG4721	ABC-type cobalt transport system, permease component
ES965_07190	COG0745	RESPONSE REGULATOR receiver
ES965_07195	COG3850	Histidine kinase
ES965_07195	COG5002	protein histidine kinase activity
ES965_07200	COG3212	peptidase
ES965_07205	COG3212	peptidase
ES965_07220	COG2239	Acts as a magnesium transporter
ES965_07225	COG0789	Transcriptional regulator
ES965_07240	COG1846	Transcriptional regulator
ES965_07245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ES965_07250	COG0726	polysaccharide deacetylase
ES965_07255	COG1408	metallophosphoesterase
ES965_07265	COG0463	Glycosyl transferase, family 2
ES965_07270	COG1793	dna ligase
ES965_07270	COG3285	dna ligase
ES965_07275	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ES965_07280	COG3300	MHYT domain
ES965_07280	COG5001	Diguanylate cyclase
ES965_07285	COG0586	Pfam SNARE associated Golgi protein
ES965_07290	COG0861	Integral membrane protein TerC family
ES965_07295	COG1191	sigma factor activity
ES965_07315	COG0501	Belongs to the peptidase M48B family
ES965_07320	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ES965_07335	COG3594	Acyltransferase
ES965_07340	COG5002	protein histidine kinase activity
ES965_07345	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ES965_07355	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ES965_07360	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
ES965_07365	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ES965_07370	COG0436	Aminotransferase
ES965_07375	COG1850	ribulose-bisphosphate carboxylase activity
ES965_07380	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ES965_07385	COG0235	Class ii aldolase
ES965_07390	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ES965_07395	COG3339	Conserved Protein
ES965_07410	COG3852	Histidine kinase
ES965_07415	COG1846	Transcriptional regulator
ES965_07420	COG1360	Flagellar Motor Protein
ES965_07425	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ES965_07435	COG0542	response to heat
ES965_07440	COG3949	Membrane
ES965_07445	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ES965_07450	COG0720	synthase
ES965_07455	COG0602	queuosine metabolic process
ES965_07460	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ES965_07465	COG1733	regulation of RNA biosynthetic process
ES965_07470	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_07475	COG1388	LysM domain
ES965_07475	COG4641	Protein conserved in bacteria
ES965_07480	COG1388	LysM domain
ES965_07485	COG3858	chitin binding
ES965_07495	COG4873	Protein conserved in bacteria
ES965_07505	COG3773	Cell wall hydrolase
ES965_07510	COG2244	polysaccharide biosynthetic process
ES965_07515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES965_07520	COG2217	Heavy metal translocating P-type atpase
ES965_07530	COG0006	proline dipeptidase activity
ES965_07535	COG1609	Transcriptional regulator
ES965_07540	COG3711	transcriptional antiterminator
ES965_07545	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES965_07545	COG2190	(PTS) system
ES965_07545	COG1263	PTS System
ES965_07550	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES965_07555	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ES965_07565	COG1533	DNA photolyase activity
ES965_07570	COG0456	acetyltransferase
ES965_07575	COG0840	transmembrane signaling receptor activity
ES965_07580	COG2084	Dehydrogenase
ES965_07585	COG4257	antibiotic catabolic process
ES965_07590	COG2340	Cysteine-rich secretory protein family
ES965_07595	COG0768	penicillin binding
ES965_07600	COG4191	Histidine kinase
ES965_07605	COG0436	Aminotransferase
ES965_07615	COG0784	Response regulator, receiver
ES965_07615	COG0835	chemotaxis
ES965_07625	COG2814	Major facilitator Superfamily
ES965_07630	COG1376	ErfK ybiS ycfS ynhG family protein
ES965_07635	COG1408	metallophosphoesterase
ES965_07640	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_07645	COG2200	EAL domain
ES965_07650	COG4703	Protein of unknown function (DUF1797)
ES965_07655	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
ES965_07665	COG0517	IMP dehydrogenase activity
ES965_07670	COG0583	DNA-binding transcription factor activity
ES965_07675	COG0716	FMN binding
ES965_07685	COG0716	FMN binding
ES965_07690	COG2171	N-acyltransferase activity
ES965_07695	COG1473	amidohydrolase
ES965_07705	COG0668	transmembrane transport
ES965_07710	COG0450	alkyl hydroperoxide reductase
ES965_07715	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES965_07730	COG0746	molybdenum cofactor guanylyltransferase activity
ES965_07735	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ES965_07740	COG0303	'Molybdopterin
ES965_07745	COG1763	Mo-molybdopterin cofactor biosynthetic process
ES965_07750	COG0314	molybdopterin synthase activity
ES965_07755	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ES965_07760	COG1132	(ABC) transporter
ES965_07765	COG1132	(ABC) transporter
ES965_07775	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ES965_07780	COG1136	(ABC) transporter
ES965_07785	COG0577	efflux transmembrane transporter activity
ES965_07790	COG1349	DNA-binding transcription factor activity
ES965_07795	COG1105	Belongs to the carbohydrate kinase PfkB family
ES965_07800	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES965_07800	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES965_07800	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES965_07805	COG0681	Belongs to the peptidase S26 family
ES965_07815	COG0488	(ABC) transporter
ES965_07820	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ES965_07825	COG2309	aminopeptidase activity
ES965_07835	COG1077	Cell shape determining protein MreB Mrl
ES965_07840	COG2002	toxin-antitoxin pair type II binding
ES965_07845	COG3852	Histidine kinase
ES965_07850	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
ES965_07850	COG2105	PFAM AIG2 family protein
ES965_07855	COG0569	domain protein
ES965_07860	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ES965_07865	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ES965_07875	COG0561	phosphatase activity
ES965_07880	COG0242	peptide deformylase activity
ES965_07890	COG0497	DNA recombination
ES965_07895	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES965_07900	COG0022	dehydrogenase e1 component
ES965_07905	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES965_07910	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES965_07915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES965_07925	COG1982	Orn Lys Arg decarboxylase major
ES965_07930	COG4476	Belongs to the UPF0223 family
ES965_07935	COG4493	Belongs to the UPF0637 family
ES965_07945	COG0483	inositol monophosphate 1-phosphatase activity
ES965_07955	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ES965_07975	COG1595	DNA-templated transcription, initiation
ES965_08005	COG4896	Protein conserved in bacteria
ES965_08015	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ES965_08020	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ES965_08025	COG2066	Belongs to the glutaminase family
ES965_08030	COG4838	Belongs to the UPF0358 family
ES965_08035	COG0772	Belongs to the SEDS family
ES965_08040	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ES965_08045	COG1612	heme a metabolic process
ES965_08050	COG0109	protoheme IX farnesyltransferase activity
ES965_08055	COG2010	Cytochrome c
ES965_08055	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ES965_08060	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ES965_08065	COG1845	cytochrome c oxidase, subunit III
ES965_08070	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ES965_08075	COG3336	cytochrome c oxidase
ES965_08085	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ES965_08090	COG2340	Cysteine-rich secretory protein family
ES965_08105	COG3679	Belongs to the UPF0342 family
ES965_08110	COG4471	UPF0298 protein
ES965_08115	COG0742	ribosomal rna small subunit methyltransferase
ES965_08120	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ES965_08125	COG3314	Sporulation integral membrane protein YlbJ
ES965_08130	COG1752	Esterase of the alpha-beta hydrolase superfamily
ES965_08135	COG3480	Lon protease (S16) C-terminal proteolytic domain
ES965_08140	COG1323	Belongs to the UPF0348 family
ES965_08150	COG1399	metal-binding, possibly nucleic acid-binding protein
ES965_08155	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ES965_08165	COG0454	-acetyltransferase
ES965_08170	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ES965_08175	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ES965_08180	COG2001	Belongs to the MraZ family
ES965_08185	COG0275	rRNA processing
ES965_08190	COG4839	cell division protein FtsL
ES965_08200	COG0768	penicillin binding
ES965_08205	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ES965_08210	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ES965_08215	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ES965_08220	COG0772	Belongs to the SEDS family
ES965_08225	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ES965_08230	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ES965_08235	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ES965_08240	COG3879	Bacterial protein of unknown function (DUF881)
ES965_08245	COG3879	Bacterial protein of unknown function (DUF881)
ES965_08250	COG3856	small basic protein
ES965_08255	COG0849	cell division
ES965_08260	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ES965_08265	COG1404	Belongs to the peptidase S8 family
ES965_08265	COG4412	M6 family metalloprotease domain protein
ES965_08275	COG1191	sigma factor activity
ES965_08280	COG1191	sigma factor activity
ES965_08285	COG1119	ATPase activity
ES965_08290	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES965_08295	COG1873	PFAM PRC-barrel domain
ES965_08305	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ES965_08310	COG1799	cell septum assembly
ES965_08315	COG0762	integral membrane protein
ES965_08320	COG2302	S4 RNA-binding domain
ES965_08325	COG3599	regulation of cell shape
ES965_08330	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ES965_08335	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES965_08340	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ES965_08345	COG0564	pseudouridine synthase activity
ES965_08350	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ES965_08355	COG2233	PERMEase
ES965_08360	COG0540	Belongs to the ATCase OTCase family
ES965_08365	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ES965_08370	COG0505	Belongs to the CarA family
ES965_08375	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ES965_08380	COG0543	2 iron, 2 sulfur cluster binding
ES965_08385	COG0167	dihydroorotate dehydrogenase activity
ES965_08390	COG0284	orotidine-5'-phosphate decarboxylase activity
ES965_08395	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ES965_08400	COG0175	sulfate reduction
ES965_08405	COG0306	phosphate transporter
ES965_08410	COG2046	Belongs to the sulfate adenylyltransferase family
ES965_08415	COG0529	Catalyzes the synthesis of activated sulfate
ES965_08420	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ES965_08425	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
ES965_08430	COG1648	precorrin-2 dehydrogenase activity
ES965_08440	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ES965_08445	COG1561	YicC-like family, N-terminal region
ES965_08450	COG2052	Domain of unknown function (DUF370)
ES965_08455	COG0194	GDP metabolic process
ES965_08460	COG1758	RNA polymerase activity
ES965_08465	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ES965_08470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ES965_08475	COG0242	peptide deformylase activity
ES965_08480	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ES965_08485	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ES965_08485	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ES965_08490	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ES965_08495	COG0631	protein serine/threonine phosphatase activity
ES965_08500	COG0515	serine threonine protein kinase
ES965_08500	COG2815	serine threonine protein kinase
ES965_08505	COG1162	GTPase activity
ES965_08510	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ES965_08515	COG1564	THIamine pyrophosphokinase
ES965_08525	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ES965_08530	COG1302	Protein conserved in bacteria
ES965_08535	COG1461	Dihydroxyacetone kinase
ES965_08540	COG1760	l-serine dehydratase
ES965_08545	COG1760	l-serine dehydratase
ES965_08550	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ES965_08555	COG1349	DNA-binding transcription factor activity
ES965_08555	COG2050	protein possibly involved in aromatic compounds catabolism
ES965_08560	COG0416	fatty acid biosynthetic process
ES965_08565	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ES965_08570	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_08575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES965_08580	COG0571	ribonuclease III activity
ES965_08585	COG1196	nuclear chromosome segregation
ES965_08590	COG0552	protein localization to endoplasmic reticulum
ES965_08600	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ES965_08605	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ES965_08610	COG0228	four-way junction DNA binding
ES965_08615	COG1837	Belongs to the UPF0109 family
ES965_08625	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ES965_08630	COG0336	Belongs to the RNA methyltransferase TrmD family
ES965_08635	COG0335	large ribosomal subunit rRNA binding
ES965_08640	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ES965_08645	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ES965_08655	COG2257	FlhB HrpN YscU SpaS Family
ES965_08660	COG0045	succinate-CoA ligase (ADP-forming) activity
ES965_08665	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ES965_08670	COG0758	DNA mediated transformation
ES965_08675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ES965_08680	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ES965_08685	COG4974	Belongs to the 'phage' integrase family
ES965_08690	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ES965_08695	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ES965_08700	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ES965_08705	COG1815	bacterial-type flagellum-dependent cell motility
ES965_08710	COG1558	bacterial-type flagellum-dependent cell motility
ES965_08715	COG1677	Flagellar hook-basal body complex protein FliE
ES965_08720	COG1766	The M ring may be actively involved in energy transduction
ES965_08725	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES965_08730	COG1317	bacterial-type flagellum organization
ES965_08735	COG1157	protein secretion by the type III secretion system
ES965_08740	COG2882	bacterial-type flagellum organization
ES965_08745	COG3334	PFAM MgtE intracellular
ES965_08750	COG3144	bacterial-type flagellum assembly
ES965_08755	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ES965_08760	COG4786	Flagellar basal body rod
ES965_08765	COG1582	Flagellar protein (FlbD)
ES965_08770	COG1580	Controls the rotational direction of flagella during chemotaxis
ES965_08775	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES965_08780	COG1776	CheC inhibitor of MCP methylation
ES965_08780	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES965_08785	COG2201	protein-glutamate methylesterase activity
ES965_08790	COG3190	flagellar
ES965_08795	COG1338	Plays a role in the flagellum-specific transport system
ES965_08800	COG1987	bacterial-type flagellum assembly
ES965_08805	COG1684	flagellar biosynthetic protein fliR
ES965_08810	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ES965_08815	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ES965_08820	COG1419	protein localization to endoplasmic reticulum
ES965_08825	COG0455	bacterial-type flagellum organization
ES965_08830	COG2201	protein-glutamate methylesterase activity
ES965_08835	COG0643	Histidine kinase
ES965_08835	COG2198	Histidine kinase
ES965_08840	COG0835	chemotaxis
ES965_08845	COG1776	CheC inhibitor of MCP methylation
ES965_08850	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ES965_08855	COG1191	sigma factor activity
ES965_08865	COG0052	Belongs to the universal ribosomal protein uS2 family
ES965_08870	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ES965_08875	COG0528	UMP kinase activity
ES965_08880	COG0233	cytoplasmic translational termination
ES965_08885	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ES965_08890	COG4589	Belongs to the CDS family
ES965_08895	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ES965_08900	COG0750	zinc metalloprotease
ES965_08905	COG0442	prolyl-tRNA aminoacylation
ES965_08910	COG2176	DNA-directed DNA polymerase activity
ES965_08915	COG0779	Required for maturation of 30S ribosomal subunits
ES965_08920	COG0195	Participates in both transcription termination and antitermination
ES965_08925	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ES965_08930	COG1358	cellular component organization or biogenesis
ES965_08935	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ES965_08940	COG1550	Protein conserved in bacteria
ES965_08945	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ES965_08950	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ES965_08955	COG0196	riboflavin kinase activity
ES965_08960	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ES965_08965	COG1185	polyribonucleotide nucleotidyltransferase activity
ES965_08970	COG0726	polysaccharide deacetylase
ES965_08975	COG0612	Peptidase, M16
ES965_08980	COG1873	PFAM PRC-barrel domain
ES965_08985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ES965_08990	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ES965_08995	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ES965_09000	COG0527	aspartate kinase activity
ES965_09005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ES965_09010	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ES965_09015	COG0740	serine-type endopeptidase activity
ES965_09025	COG4980	gas vesicle protein
ES965_09025	COG1674	ftsk spoiiie
ES965_09030	COG2188	Transcriptional regulator
ES965_09035	COG2814	Major facilitator Superfamily
ES965_09040	COG0612	Peptidase, M16
ES965_09045	COG0612	Peptidase, M16
ES965_09050	COG0300	oxidoreductase activity
ES965_09065	COG1426	Protein conserved in bacteria
ES965_09070	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ES965_09075	COG1546	Belongs to the CinA family
ES965_09075	COG1058	Belongs to the CinA family
ES965_09080	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ES965_09085	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ES965_09090	COG1418	mRNA catabolic process
ES965_09095	COG1692	metallophosphoesterase
ES965_09100	COG2359	stage V sporulation protein S
ES965_09105	COG1063	alcohol dehydrogenase
ES965_09110	COG0156	8-amino-7-oxononanoate synthase activity
ES965_09115	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ES965_09120	COG4550	Control of competence regulator ComK, YlbF/YmcA
ES965_09130	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ES965_09135	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ES965_09150	COG3226	Transcriptional regulator
ES965_09155	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES965_09165	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ES965_09170	COG3321	synthase
ES965_09175	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ES965_09175	COG2070	2-Nitropropane dioxygenase
ES965_09180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES965_09185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ES965_09190	COG3425	synthase
ES965_09195	COG1024	Enoyl-CoA hydratase
ES965_09200	COG1024	Enoyl-CoA hydratase
ES965_09205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_09205	COG3321	synthase
ES965_09205	COG0318	PFAM AMP-dependent synthetase and ligase
ES965_09205	COG0300	oxidoreductase activity
ES965_09205	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_09210	COG3321	synthase
ES965_09210	COG0300	oxidoreductase activity
ES965_09210	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES965_09210	COG4221	oxidoreductase activity
ES965_09215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES965_09215	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES965_09215	COG3321	synthase
ES965_09215	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_09215	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_09220	COG4221	oxidoreductase activity
ES965_09220	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_09220	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_09220	COG3321	synthase
ES965_09225	COG3321	synthase
ES965_09225	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
ES965_09225	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
ES965_09225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES965_09230	COG2124	cytochrome p450
ES965_09240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES965_09245	COG1404	Belongs to the peptidase S8 family
ES965_09255	COG4195	phage-related replication protein
ES965_09260	COG1764	response to oxidative stress
ES965_09265	COG2076	Multidrug Resistance protein
ES965_09270	COG2076	Multidrug Resistance protein
ES965_09285	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ES965_09290	COG1923	regulation of RNA biosynthetic process
ES965_09305	COG1780	Probably involved in ribonucleotide reductase function
ES965_09310	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES965_09315	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES965_09320	COG4112	unkown
ES965_09325	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES965_09335	COG0464	growth
ES965_09340	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ES965_09345	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ES965_09350	COG0789	Transcriptional regulator
ES965_09355	COG0174	glutamine synthetase
ES965_09450	COG4282	regulation of fungal-type cell wall biogenesis
ES965_09465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES965_09495	COG0135	phosphoribosylanthranilate isomerase activity
ES965_09500	COG2211	Major facilitator Superfamily
ES965_09505	COG3507	Belongs to the glycosyl hydrolase 43 family
ES965_09510	COG1940	carbohydrate kinase activity
ES965_09515	COG2115	Belongs to the xylose isomerase family
ES965_09520	COG1070	Carbohydrate kinase
ES965_09530	COG1525	nuclease
ES965_09535	COG2814	Major facilitator Superfamily
ES965_09540	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ES965_09555	COG0756	dUTP diphosphatase activity
ES965_09595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ES965_09605	COG3832	glyoxalase III activity
ES965_09620	COG0697	spore germination
ES965_09625	COG0531	amino acid
ES965_09655	COG4195	phage-related replication protein
ES965_09665	COG0346	lactoylglutathione lyase activity
ES965_09675	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ES965_09680	COG1388	LysM domain
ES965_09685	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ES965_09690	COG4224	UPF0291 protein
ES965_09695	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ES965_09705	COG3763	UPF0154 protein
ES965_09715	COG0785	Cytochrome C biogenesis protein
ES965_09720	COG2201	protein-glutamate methylesterase activity
ES965_09725	COG4846	Membrane protein involved in cytochrome C biogenesis
ES965_09735	COG0071	Belongs to the small heat shock protein (HSP20) family
ES965_09750	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ES965_09755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES965_09775	COG0824	Thioesterase
ES965_09785	COG4841	protein insertion into membrane
ES965_09790	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ES965_09795	COG1832	CoA-binding protein
ES965_09800	COG0187	DNA topoisomerase II activity
ES965_09805	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ES965_09815	COG1115	amino acid carrier protein
ES965_09820	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ES965_09830	COG5520	Belongs to the glycosyl hydrolase 30 family
ES965_09835	COG3507	Belongs to the glycosyl hydrolase 43 family
ES965_09840	COG2246	polysaccharide biosynthetic process
ES965_09845	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ES965_09850	COG0586	Pfam SNARE associated Golgi protein
ES965_09855	COG2404	hydrolase activity, acting on ester bonds
ES965_09860	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ES965_09865	COG1024	Enoyl-CoA hydratase
ES965_09870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ES965_09875	COG0511	ligase activity, forming carbon-carbon bonds
ES965_09880	COG0439	Biotin carboxylase
ES965_09885	COG0318	PFAM AMP-dependent synthetase and ligase
ES965_09890	COG1960	acyl-CoA dehydrogenase activity
ES965_09905	COG1649	PFAM Uncharacterised BCR, COG1649
ES965_09915	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
ES965_09915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_09920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_09925	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_09930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_09935	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_09940	COG2027	D-alanyl-D-alanine carboxypeptidase
ES965_09945	COG2017	converts alpha-aldose to the beta-anomer
ES965_09950	COG0534	Mate efflux family protein
ES965_09965	COG0582	viral genome integration into host DNA
ES965_09970	COG0166	Belongs to the GPI family
ES965_09975	COG0405	Gamma-glutamyltransferase
ES965_09980	COG0583	DNA-binding transcription factor activity
ES965_09985	COG0604	alcohol dehydrogenase
ES965_09990	COG0493	'glutamate synthase
ES965_09995	COG0070	glutamate synthase
ES965_09995	COG0069	glutamate synthase activity
ES965_09995	COG0067	glutamate synthase
ES965_10000	COG0583	DNA-binding transcription factor activity
ES965_10005	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ES965_10010	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES965_10020	COG0300	oxidoreductase activity
ES965_10025	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ES965_10035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES965_10040	COG2814	Major facilitator Superfamily
ES965_10045	COG1070	Carbohydrate kinase
ES965_10050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ES965_10055	COG0243	molybdopterin cofactor binding
ES965_10080	COG5278	phosphoserine phosphatase activity
ES965_10080	COG0840	transmembrane signaling receptor activity
ES965_10085	COG2368	4-hydroxyphenylacetate
ES965_10090	COG4305	rare lipoprotein A
ES965_10095	COG3619	membrane
ES965_10100	COG3866	Pectate lyase
ES965_10105	COG2135	peptidase activity
ES965_10115	COG2140	Oxalate decarboxylase
ES965_10140	COG2720	vancomycin resistance protein
ES965_10155	COG3739	integral membrane protein
ES965_10160	COG0583	DNA-binding transcription factor activity
ES965_10165	COG0697	spore germination
ES965_10175	COG0693	protein deglycase activity
ES965_10180	COG2367	Beta-lactamase
ES965_10205	COG3848	Pyruvate phosphate dikinase
ES965_10205	COG0574	Belongs to the PEP-utilizing enzyme family
ES965_10210	COG0726	polysaccharide deacetylase
ES965_10305	COG3655	Transcriptional regulator
ES965_10330	COG1404	Belongs to the peptidase S8 family
ES965_10360	COG0457	Tetratricopeptide repeat
ES965_10370	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ES965_10380	COG4282	regulation of fungal-type cell wall biogenesis
ES965_10385	COG1231	oxidoreductase activity
ES965_10390	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES965_10395	COG0662	Cupin 2, conserved barrel domain protein
ES965_10395	COG2207	Transcriptional regulator
ES965_10400	COG0456	acetyltransferase
ES965_10405	COG1309	transcriptional regulator
ES965_10410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES965_10415	COG3708	Transcriptional regulator
ES965_10420	COG2378	regulation of single-species biofilm formation
ES965_10430	COG0640	Transcriptional regulator
ES965_10435	COG0741	lytic transglycosylase activity
ES965_10440	COG2322	membrane
ES965_10455	COG1619	proteins homologs of microcin C7 resistance protein MccF
ES965_10460	COG3239	Fatty acid desaturase
ES965_10465	COG4585	Histidine kinase
ES965_10470	COG2197	response regulator
ES965_10475	COG3584	3D domain protein
ES965_10475	COG1388	LysM domain
ES965_10480	COG0514	ATP-dependent DNA helicase (RecQ)
ES965_10495	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ES965_10500	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES965_10515	COG0071	Belongs to the small heat shock protein (HSP20) family
ES965_10540	COG1012	belongs to the aldehyde dehydrogenase family
ES965_10545	COG1657	PFAM Prenyltransferase squalene oxidase
ES965_10550	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ES965_10555	COG0733	neurotransmitter:sodium symporter activity
ES965_10560	COG0385	Bile acid
ES965_10565	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES965_10570	COG0567	Dehydrogenase, E1 component
ES965_10575	COG4548	von Willebrand factor, type A
ES965_10580	COG0714	Associated with various cellular activities
ES965_10585	COG2032	superoxide dismutase activity
ES965_10590	COG0791	NLP P60 protein
ES965_10590	COG1388	LysM domain
ES965_10595	COG1819	glycosyl
ES965_10600	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ES965_10605	COG0534	Mate efflux family protein
ES965_10610	COG1366	Belongs to the anti-sigma-factor antagonist family
ES965_10615	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES965_10620	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES965_10630	COG2962	Rard protein
ES965_10645	COG2610	gluconate transmembrane transporter activity
ES965_10650	COG1942	4-Oxalocrotonate Tautomerase
ES965_10655	COG1733	regulation of RNA biosynthetic process
ES965_10660	COG0778	Nitroreductase
ES965_10665	COG0400	carboxylic ester hydrolase activity
ES965_10670	COG0346	lactoylglutathione lyase activity
ES965_10680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES965_10685	COG3409	Peptidoglycan-binding domain 1 protein
ES965_10685	COG0793	Belongs to the peptidase S41A family
ES965_10690	COG2226	methyltransferase
ES965_10700	COG1876	peptidase activity
ES965_10705	COG0813	purine-nucleoside phosphorylase activity
ES965_10720	COG0671	phosphoesterase, PA-phosphatase related
ES965_10745	COG4479	Belongs to the UPF0346 family
ES965_10755	COG1509	lysine 2,3-aminomutase activity
ES965_10760	COG0456	acetyltransferase
ES965_10765	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES965_10770	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ES965_10775	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ES965_10780	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES965_10795	COG0456	acetyltransferase
ES965_10800	COG0463	Glycosyl transferase, family 2
ES965_10815	COG4641	Protein conserved in bacteria
ES965_10820	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
ES965_10825	COG1086	Polysaccharide biosynthesis protein
ES965_10830	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ES965_10835	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ES965_10840	COG1846	Transcriptional regulator
ES965_10845	COG0534	Mate efflux family protein
ES965_10855	COG4698	Protein conserved in bacteria
ES965_10860	COG2755	lipolytic protein G-D-S-L family
ES965_10865	COG1999	signal sequence binding
ES965_10875	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ES965_10880	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ES965_10885	COG1272	protein, Hemolysin III
ES965_10890	COG0204	Acyl-transferase
ES965_10895	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ES965_10900	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
ES965_10905	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ES965_10915	COG2521	methyltransferase
ES965_10915	COG2136	Putative SAM-dependent methyltransferase
ES965_10925	COG0129	dihydroxy-acid dehydratase activity
ES965_10930	COG1413	lyase activity
ES965_10935	COG1418	mRNA catabolic process
ES965_10940	COG0386	Belongs to the glutathione peroxidase family
ES965_10945	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ES965_10950	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ES965_10960	COG1278	Cold shock
ES965_10980	COG0328	RNA-DNA hybrid ribonuclease activity
ES965_10985	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ES965_10990	COG0328	RNA-DNA hybrid ribonuclease activity
ES965_11000	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES965_11015	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ES965_11025	COG1755	Isoprenylcysteine carboxyl methyltransferase
ES965_11030	COG3424	synthase
ES965_11035	COG2233	PERMEase
ES965_11040	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ES965_11045	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ES965_11055	COG0800	Aldolase
ES965_11060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES965_11065	COG1609	Transcriptional regulator
ES965_11070	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ES965_11075	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_11080	COG1199	ATP-dependent helicase activity
ES965_11095	COG0116	Belongs to the methyltransferase superfamily
ES965_11110	COG4474	Belongs to the UPF0398 family
ES965_11125	COG3359	exonuclease
ES965_11130	COG1111	helicase
ES965_11130	COG1205	dead DEAH box helicase
ES965_11135	COG2190	(PTS) system
ES965_11140	COG0071	Belongs to the small heat shock protein (HSP20) family
ES965_11175	COG3331	DNA recombination
ES965_11180	COG4499	WXG100 protein secretion system (Wss), protein YukC
ES965_11180	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES965_11190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ES965_11195	COG3935	DnaD domain protein
ES965_11200	COG0017	Asparaginyl-tRNA synthetase
ES965_11205	COG0436	Aminotransferase
ES965_11210	COG5353	protein conserved in bacteria
ES965_11220	COG1199	ATP-dependent helicase activity
ES965_11220	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ES965_11225	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ES965_11230	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ES965_11235	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ES965_11240	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ES965_11240	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ES965_11245	COG0617	tRNA 3'-terminal CCA addition
ES965_11250	COG0438	transferase activity, transferring glycosyl groups
ES965_11255	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES965_11260	COG1803	Methylglyoxal synthase
ES965_11265	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ES965_11270	COG1694	Mazg nucleotide pyrophosphohydrolase
ES965_11275	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES965_11285	COG4347	Protein of unknown function (DUF1405)
ES965_11290	COG2010	Cytochrome c
ES965_11290	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ES965_11295	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ES965_11300	COG0723	plastoquinol--plastocyanin reductase activity
ES965_11310	COG5582	Belongs to the UPF0302 family
ES965_11315	COG0457	Tetratricopeptide repeat
ES965_11320	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ES965_11325	COG0287	Prephenate dehydrogenase
ES965_11330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ES965_11335	COG0159	tryptophan synthase activity
ES965_11340	COG0133	tryptophan synthase activity
ES965_11345	COG0135	phosphoribosylanthranilate isomerase activity
ES965_11355	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ES965_11360	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ES965_11365	COG4401	Chorismate mutase type I
ES965_11370	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ES965_11375	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ES965_11380	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ES965_11385	COG0105	UTP biosynthetic process
ES965_11390	COG0142	geranyltranstransferase activity
ES965_11395	COG2226	methyltransferase
ES965_11400	COG0142	geranyltranstransferase activity
ES965_11410	COG0302	gtp cyclohydrolase
ES965_11415	COG0776	regulation of translation
ES965_11420	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ES965_11435	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ES965_11440	COG1160	GTP binding
ES965_11465	COG1304	FMN binding
ES965_11470	COG0539	negative regulation of cytoplasmic translation
ES965_11475	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ES965_11485	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
ES965_11490	COG2959	enzyme of heme biosynthesis
ES965_11495	COG3773	Cell wall hydrolase
ES965_11495	COG3409	Peptidoglycan-binding domain 1 protein
ES965_11500	COG2339	peptidase activity
ES965_11505	COG0492	ferredoxin-NADP+ reductase activity
ES965_11510	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES965_11515	COG4862	establishment of competence for transformation
ES965_11520	COG1408	metallophosphoesterase
ES965_11530	COG1388	LysM domain
ES965_11535	COG1266	CAAX protease self-immunity
ES965_11540	COG0514	ATP-dependent DNA helicase (RecQ)
ES965_11545	COG4955	Helix-turn-helix domain
ES965_11550	COG1141	Ferredoxin
ES965_11555	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ES965_11560	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ES965_11565	COG0710	3-dehydroquinate dehydratase activity
ES965_11575	COG1595	DNA-templated transcription, initiation
ES965_11580	COG5002	protein histidine kinase activity
ES965_11585	COG0745	RESPONSE REGULATOR receiver
ES965_11590	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ES965_11595	COG1333	cytochrome c biogenesis protein
ES965_11600	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES965_11605	COG1187	pseudouridine synthase activity
ES965_11610	COG0700	Nucleoside recognition
ES965_11615	COG2715	membrane protein required for spore maturation
ES965_11620	COG1686	Belongs to the peptidase S11 family
ES965_11630	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ES965_11635	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ES965_11640	COG1547	Domain of unknown function (DUF309)
ES965_11645	COG0456	acetyltransferase
ES965_11650	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ES965_11655	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ES965_11655	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ES965_11660	COG0307	riboflavin synthase, alpha
ES965_11665	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ES965_11665	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ES965_11675	COG0681	Belongs to the peptidase S26 family
ES965_11685	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
ES965_11715	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ES965_11725	COG4086	secreted protein
ES965_11730	COG0019	diaminopimelate decarboxylase activity
ES965_11735	COG0697	spore germination
ES965_11750	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES965_11770	COG1191	sigma factor activity
ES965_11775	COG2172	sigma factor antagonist activity
ES965_11780	COG1366	Belongs to the anti-sigma-factor antagonist family
ES965_11785	COG1686	Belongs to the peptidase S11 family
ES965_11790	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ES965_11795	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ES965_11800	COG4974	Belongs to the 'phage' integrase family
ES965_11810	COG0735	belongs to the Fur family
ES965_11815	COG1300	Membrane
ES965_11825	COG0281	malic enzyme
ES965_11830	COG1757	Na H antiporter
ES965_11835	COG1027	Aspartate ammonia-lyase
ES965_11840	COG0252	asparaginase activity
ES965_11845	COG1396	sequence-specific DNA binding
ES965_11850	COG1379	DNA repair
ES965_11855	COG0494	nUDIX hydrolase
ES965_11865	COG0667	Aldo Keto reductase
ES965_11875	COG1073	alpha beta
ES965_11885	COG4918	Iron-sulphur cluster biosynthesis
ES965_11890	COG0456	acetyltransferase
ES965_11890	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ES965_11895	COG2329	Antibiotic biosynthesis monooxygenase
ES965_11900	COG0456	acetyltransferase
ES965_11910	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ES965_11920	COG2211	Major facilitator Superfamily
ES965_11925	COG0346	lactoylglutathione lyase activity
ES965_11930	COG1072	(Pantothenic acid kinase))
ES965_11935	COG3048	D-serine ammonia-lyase activity
ES965_11940	COG0300	oxidoreductase activity
ES965_11945	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES965_11950	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES965_11955	COG4187	Peptidase family M20/M25/M40
ES965_11960	COG1902	pentaerythritol trinitrate reductase activity
ES965_11965	COG0596	Alpha beta hydrolase
ES965_11975	COG1234	tRNA 3'-trailer cleavage
ES965_11980	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ES965_11985	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ES965_11990	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ES965_12000	COG0706	membrane insertase activity
ES965_12005	COG3361	conserved protein (COG2071)
ES965_12010	COG2195	Cleaves the N-terminal amino acid of tripeptides
ES965_12015	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ES965_12020	COG0346	lactoylglutathione lyase activity
ES965_12025	COG1376	ErfK ybiS ycfS ynhG family protein
ES965_12030	COG4129	membrane
ES965_12035	COG1126	abc transporter atp-binding protein
ES965_12040	COG0765	amino acid transport
ES965_12045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES965_12055	COG1597	lipid kinase activity
ES965_12060	COG2814	Major facilitator Superfamily
ES965_12065	COG0789	Transcriptional regulator
ES965_12065	COG4978	Transcriptional regulator
ES965_12070	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES965_12075	COG0022	dehydrogenase e1 component
ES965_12080	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES965_12085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES965_12090	COG3426	butyrate kinase activity
ES965_12095	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES965_12100	COG0280	phosphate acetyltransferase
ES965_12105	COG3290	protein histidine kinase activity
ES965_12105	COG3829	transcription factor binding
ES965_12115	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ES965_12120	COG2079	MmgE PrpD family protein
ES965_12125	COG0372	Belongs to the citrate synthase family
ES965_12130	COG1960	acyl-CoA dehydrogenase activity
ES965_12135	COG1250	3-hydroxyacyl-CoA dehydrogenase
ES965_12140	COG0183	Belongs to the thiolase family
ES965_12145	COG0584	glycerophosphoryl diester phosphodiesterase
ES965_12150	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES965_12165	COG1902	pentaerythritol trinitrate reductase activity
ES965_12170	COG0745	RESPONSE REGULATOR receiver
ES965_12175	COG0750	zinc metalloprotease
ES965_12180	COG0497	DNA recombination
ES965_12185	COG1438	arginine binding
ES965_12190	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ES965_12195	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ES965_12200	COG0142	geranyltranstransferase activity
ES965_12205	COG1722	exodeoxyribonuclease VII activity
ES965_12210	COG1570	exodeoxyribonuclease VII activity
ES965_12215	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ES965_12220	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ES965_12225	COG1302	Protein conserved in bacteria
ES965_12230	COG0439	Biotin carboxylase
ES965_12235	COG0511	ligase activity, forming carbon-carbon bonds
ES965_12275	COG3854	ATPases associated with a variety of cellular activities
ES965_12285	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ES965_12290	COG0006	proline dipeptidase activity
ES965_12295	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ES965_12305	COG3872	metal-dependent enzyme
ES965_12315	COG1752	Esterase of the alpha-beta hydrolase superfamily
ES965_12320	COG1321	iron dependent repressor
ES965_12325	COG0095	Lipoate-protein ligase
ES965_12330	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ES965_12335	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ES965_12340	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ES965_12345	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ES965_12350	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ES965_12365	COG1396	sequence-specific DNA binding
ES965_12375	COG0681	Belongs to the peptidase S26 family
ES965_12400	COG4940	Competence protein ComGF
ES965_12410	COG4970	Tfp pilus assembly protein FimT
ES965_12415	COG4537	Required for transformation and DNA binding
ES965_12420	COG1459	type II secretion system
ES965_12425	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ES965_12430	COG0517	IMP dehydrogenase activity
ES965_12435	COG0598	Magnesium transport protein CorA
ES965_12440	COG1253	flavin adenine dinucleotide binding
ES965_12445	COG1366	Belongs to the anti-sigma-factor antagonist family
ES965_12455	COG1393	Belongs to the ArsC family
ES965_12465	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES965_12475	COG0011	TIGRFAM Protein of
ES965_12485	COG2866	Carboxypeptidase
ES965_12490	COG1368	sulfuric ester hydrolase activity
ES965_12495	COG1940	carbohydrate kinase activity
ES965_12500	COG4483	Protein conserved in bacteria
ES965_12505	COG0457	Tetratricopeptide repeat
ES965_12505	COG0705	Rhomboid family
ES965_12515	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ES965_12520	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ES965_12525	COG0438	transferase activity, transferring glycosyl groups
ES965_12540	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ES965_12545	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES965_12550	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES965_12555	COG0581	inorganic phosphate transmembrane transporter activity
ES965_12560	COG0573	inorganic phosphate transmembrane transporter activity
ES965_12565	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ES965_12575	COG0477	Major facilitator Superfamily
ES965_12580	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ES965_12585	COG2839	Protein conserved in bacteria
ES965_12590	COG5521	maltodextrose utilization protein MalA
ES965_12595	COG1388	LysM domain
ES965_12600	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ES965_12605	COG4709	membrane
ES965_12610	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
ES965_12615	COG0735	belongs to the Fur family
ES965_12620	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES965_12630	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ES965_12635	COG0513	Belongs to the DEAD box helicase family
ES965_12645	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ES965_12650	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ES965_12655	COG2384	SAM-dependent methyltransferase
ES965_12660	COG2010	Cytochrome c
ES965_12665	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ES965_12670	COG0358	DNA primase activity
ES965_12675	COG1671	Belongs to the UPF0178 family
ES965_12680	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ES965_12685	COG0517	IMP dehydrogenase activity
ES965_12690	COG0751	glycine-tRNA ligase activity
ES965_12695	COG0752	glycyl-tRNA synthetase alpha subunit
ES965_12700	COG1381	Involved in DNA repair and RecF pathway recombination
ES965_12710	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ES965_12715	COG0295	cytidine deaminase activity
ES965_12720	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ES965_12725	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ES965_12730	COG1480	7TM receptor with intracellular HD hydrolase
ES965_12735	COG1702	phosphate starvation-inducible protein PhoH
ES965_12740	COG0561	phosphatase activity
ES965_12755	COG4864	UPF0365 protein
ES965_12760	COG1030	water channel activity
ES965_12765	COG1610	YqeY-like protein
ES965_12770	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ES965_12775	COG1283	sodium-dependent phosphate transmembrane transporter activity
ES965_12780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ES965_12785	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ES965_12790	COG2264	protein methyltransferase activity
ES965_12795	COG0484	heat shock protein binding
ES965_12800	COG0443	Heat shock 70 kDa protein
ES965_12805	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ES965_12810	COG1420	regulation of RNA biosynthetic process
ES965_12815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ES965_12820	COG0481	GTPase activity
ES965_12830	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES965_12835	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ES965_12840	COG0268	Binds directly to 16S ribosomal RNA
ES965_12845	COG1466	dna polymerase III delta subunit
ES965_12860	COG0658	competence protein
ES965_12860	COG2333	competence protein COMEC
ES965_12865	COG2131	deaminase
ES965_12870	COG1555	photosystem II stabilization
ES965_12870	COG1596	polysaccharide export
ES965_12875	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES965_12880	COG2226	methyltransferase
ES965_12885	COG0799	negative regulation of ribosome biogenesis
ES965_12890	COG1713	HD superfamily hydrolase involved in NAD metabolism
ES965_12895	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ES965_12900	COG1534	Rna-binding protein
ES965_12905	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ES965_12910	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ES965_12915	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ES965_12925	COG2755	lipolytic protein G-D-S-L family
ES965_12930	COG3409	Peptidoglycan-binding domain 1 protein
ES965_12930	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES965_12935	COG0398	Pfam SNARE associated Golgi protein
ES965_12940	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ES965_12950	COG3209	COG3209 Rhs family protein
ES965_12965	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ES965_12975	COG2249	NAD(P)H dehydrogenase (quinone) activity
ES965_12985	COG0697	spore germination
ES965_12990	COG1802	Transcriptional regulator
ES965_12995	COG0730	response to heat
ES965_13000	COG0425	Belongs to the sulfur carrier protein TusA family
ES965_13005	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ES965_13005	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES965_13015	COG0425	Belongs to the sulfur carrier protein TusA family
ES965_13015	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ES965_13025	COG2210	Belongs to the sulfur carrier protein TusA family
ES965_13030	COG1937	Protein conserved in bacteria
ES965_13045	COG0662	Cupin 2, conserved barrel domain protein
ES965_13060	COG4978	Transcriptional regulator
ES965_13060	COG0789	Transcriptional regulator
ES965_13065	COG2814	Major facilitator Superfamily
ES965_13070	COG0456	acetyltransferase
ES965_13075	COG1253	flavin adenine dinucleotide binding
ES965_13085	COG0697	spore germination
ES965_13090	COG0583	DNA-binding transcription factor activity
ES965_13095	COG2072	flavoprotein involved in K transport
ES965_13100	COG1230	cation diffusion facilitator family transporter
ES965_13105	COG1942	4-Oxalocrotonate Tautomerase
ES965_13110	COG0583	DNA-binding transcription factor activity
ES965_13120	COG1114	Component of the transport system for branched-chain amino acids
ES965_13125	COG1687	branched-chain amino acid
ES965_13130	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ES965_13135	COG1522	sequence-specific DNA binding
ES965_13140	COG2732	(Barnase) inhibitor
ES965_13145	COG2124	cytochrome p450
ES965_13160	COG1609	Transcriptional regulator
ES965_13170	COG1175	transmembrane transport
ES965_13175	COG0395	ABC-type sugar transport system, permease component
ES965_13195	COG0110	maltose O-acetyltransferase activity
ES965_13205	COG1335	isochorismatase
ES965_13220	COG2318	DinB family
ES965_13230	COG2070	2-Nitropropane dioxygenase
ES965_13245	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ES965_13275	COG4978	Transcriptional regulator
ES965_13275	COG0789	Transcriptional regulator
ES965_13280	COG2315	Protein conserved in bacteria
ES965_13290	COG3443	Belongs to the bacterial solute-binding protein 9 family
ES965_13295	COG1595	DNA-templated transcription, initiation
ES965_13300	COG0667	Aldo Keto reductase
ES965_13305	COG3409	Peptidoglycan-binding domain 1 protein
ES965_13310	COG5566	PFAM Mor transcription activator
ES965_13315	COG0596	Alpha beta hydrolase
ES965_13320	COG4991	sh3 domain protein
ES965_13325	COG4991	sh3 domain protein
ES965_13330	COG0346	lactoylglutathione lyase activity
ES965_13340	COG5577	PFAM Coat F domain
ES965_13345	COG1063	alcohol dehydrogenase
ES965_13355	COG5577	PFAM Coat F domain
ES965_13360	COG0789	Transcriptional regulator
ES965_13370	COG1064	alcohol dehydrogenase
ES965_13375	COG0693	protein deglycase activity
ES965_13380	COG1621	beta-fructofuranosidase activity
ES965_13385	COG3716	PTS system mannose fructose sorbose family IID component
ES965_13390	COG3715	PTS system
ES965_13395	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES965_13400	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES965_13405	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ES965_13405	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ES965_13415	COG1113	amino acid transport
ES965_13420	COG1280	lysine exporter protein (LysE YggA)
ES965_13425	COG1378	Sugar-specific transcriptional regulator TrmB
ES965_13430	COG1595	DNA-templated transcription, initiation
ES965_13440	COG2755	lipolytic protein G-D-S-L family
ES965_13440	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ES965_13450	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ES965_13450	COG2124	cytochrome p450
ES965_13455	COG1309	transcriptional regulator
ES965_13460	COG2226	methyltransferase
ES965_13475	COG2116	formate transmembrane transporter activity
ES965_13480	COG5609	conserved protein (DUF2294)
ES965_13485	COG3383	formate dehydrogenase (NAD+) activity
ES965_13490	COG2427	Protein of unknown function (DUF1641)
ES965_13500	COG0626	cystathionine gamma-synthase activity
ES965_13505	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES965_13510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ES965_13515	COG2226	methyltransferase
ES965_13530	COG0768	penicillin binding
ES965_13535	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ES965_13540	COG0572	uridine kinase
ES965_13560	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ES965_13565	COG3906	Belongs to the UPF0473 family
ES965_13570	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ES965_13575	COG4472	Bacterial protein of unknown function (DUF965)
ES965_13580	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ES965_13585	COG0628	permease
ES965_13590	COG1126	abc transporter atp-binding protein
ES965_13595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES965_13600	COG0765	amino acid transport
ES965_13605	COG0765	amino acid transport
ES965_13620	COG3881	PFAM PRC-barrel domain
ES965_13625	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ES965_13630	COG0457	Tetratricopeptide repeat
ES965_13635	COG0482	sulfurtransferase activity
ES965_13640	COG1104	cysteine desulfurase activity
ES965_13645	COG1959	2 iron, 2 sulfur cluster binding
ES965_13650	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ES965_13655	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ES965_13665	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ES965_13670	COG0124	histidyl-tRNA synthetase
ES965_13680	COG4991	sh3 domain protein
ES965_13680	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES965_13680	COG3103	Sh3 type 3 domain protein
ES965_13685	COG1490	D-aminoacyl-tRNA deacylase activity
ES965_13690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ES965_13695	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ES965_13700	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ES965_13700	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ES965_13705	COG5416	Lipopolysaccharide assembly protein A domain
ES965_13710	COG0490	domain, Protein
ES965_13715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ES965_13715	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ES965_13725	COG2244	polysaccharide biosynthetic process
ES965_13730	COG2323	membrane
ES965_13745	COG1862	Preprotein translocase
ES965_13750	COG0343	queuine tRNA-ribosyltransferase activity
ES965_13755	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ES965_13765	COG2255	four-way junction helicase activity
ES965_13770	COG0632	four-way junction helicase activity
ES965_13780	COG2814	Major facilitator Superfamily
ES965_13785	COG0673	inositol 2-dehydrogenase activity
ES965_13790	COG2112	serine threonine protein kinase
ES965_13810	COG1115	amino acid carrier protein
ES965_13815	COG0217	transcriptional regulatory protein
ES965_13825	COG1388	LysM domain
ES965_13830	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ES965_13835	COG0157	Belongs to the NadC ModD family
ES965_13840	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ES965_13845	COG1104	cysteine desulfurase activity
ES965_13850	COG1827	regulation of RNA biosynthetic process
ES965_13855	COG0077	Prephenate dehydratase
ES965_13860	COG4492	Belongs to the UPF0735 family
ES965_13865	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ES965_13870	COG3290	protein histidine kinase activity
ES965_13880	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ES965_13885	COG2868	ribosomal protein
ES965_13890	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ES965_13895	COG1994	Peptidase M50
ES965_13900	COG0739	heme binding
ES965_13905	COG2894	cell division
ES965_13910	COG0850	regulation of cytokinetic process
ES965_13915	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ES965_13920	COG1792	Involved in formation and maintenance of cell shape
ES965_13925	COG1077	Cell shape determining protein MreB Mrl
ES965_13930	COG2003	Belongs to the UPF0758 family
ES965_13935	COG0424	maF-like protein
ES965_13945	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ES965_13950	COG0285	dihydrofolate synthase activity
ES965_13955	COG0525	valine-tRNA ligase activity
ES965_13965	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES965_13970	COG1388	LysM domain
ES965_13975	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ES965_13980	COG0113	porphobilinogen synthase activity
ES965_13985	COG1587	Uroporphyrinogen-III synthase
ES965_13990	COG0181	hydroxymethylbilane synthase activity
ES965_13995	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ES965_14000	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ES965_14010	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ES965_14015	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ES965_14020	COG0470	DNA polymerase III
ES965_14020	COG1067	ATP-dependent peptidase activity
ES965_14025	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ES965_14030	COG0544	peptidyl-prolyl cis-trans isomerase activity
ES965_14035	COG1477	protein flavinylation
ES965_14035	COG0457	Tetratricopeptide repeat
ES965_14040	COG0066	3-isopropylmalate dehydratase activity
ES965_14045	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ES965_14050	COG0473	3-isopropylmalate dehydrogenase activity
ES965_14055	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ES965_14060	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ES965_14065	COG0440	acetolactate synthase activity
ES965_14070	COG0028	Belongs to the TPP enzyme family
ES965_14080	COG0454	-acetyltransferase
ES965_14090	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
ES965_14115	COG1674	ftsk spoiiie
ES965_14145	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES965_14145	COG3409	Peptidoglycan-binding domain 1 protein
ES965_14145	COG1388	LysM domain
ES965_14180	COG5280	Phage tail tape measure protein TP901
ES965_14180	COG3953	SLT domain
ES965_14225	COG0740	serine-type endopeptidase activity
ES965_14275	COG0322	excinuclease ABC activity
ES965_14280	COG1216	Glycosyl transferase, family 2
ES965_14290	COG4195	phage-related replication protein
ES965_14295	COG5434	Belongs to the glycosyl hydrolase 28 family
ES965_14295	COG3420	alginic acid biosynthetic process
ES965_14360	COG1388	LysM domain
ES965_14360	COG3584	3D domain protein
ES965_14365	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
ES965_14370	COG0756	dUTP diphosphatase activity
ES965_14375	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES965_14385	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES965_14390	COG1780	Probably involved in ribonucleotide reductase function
ES965_14430	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES965_14430	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES965_14490	COG1484	DNA-dependent DNA replication
ES965_14540	COG0622	Phosphoesterase
ES965_14545	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ES965_14550	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ES965_14555	COG5401	PFAM Sporulation and spore germination
ES965_14560	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ES965_14565	COG1846	Transcriptional regulator
ES965_14570	COG2197	response regulator
ES965_14575	COG0824	Thioesterase
ES965_14580	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ES965_14585	COG1053	succinate dehydrogenase
ES965_14590	COG2009	succinate dehydrogenase
ES965_14595	COG1719	4-vinyl reductase, 4VR
ES965_14600	COG0527	aspartate kinase activity
ES965_14610	COG0322	excinuclease ABC activity
ES965_14615	COG3118	belongs to the thioredoxin family
ES965_14625	COG3534	alpha-L-arabinofuranosidase
ES965_14630	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ES965_14635	COG2086	electron transfer activity
ES965_14640	COG1024	Enoyl-CoA hydratase
ES965_14645	COG1309	transcriptional regulator
ES965_14650	COG0318	PFAM AMP-dependent synthetase and ligase
ES965_14655	COG3766	membrane
ES965_14660	COG1193	negative regulation of DNA recombination
ES965_14665	COG1796	DNA polymerase
ES965_14665	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ES965_14670	COG1286	toxin biosynthetic process
ES965_14675	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ES965_14680	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ES965_14685	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES965_14685	COG0072	phenylalanine-tRNA ligase activity
ES965_14690	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ES965_14700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ES965_14710	COG3835	regulator
ES965_14715	COG0277	FAD linked oxidase domain protein
ES965_14720	COG0247	lactate metabolic process
ES965_14725	COG0346	lactoylglutathione lyase activity
ES965_14735	COG1966	Carbon starvation protein
ES965_14740	COG3534	alpha-L-arabinofuranosidase
ES965_14745	COG0395	ABC-type sugar transport system, permease component
ES965_14750	COG1175	transmembrane transport
ES965_14755	COG1653	transport
ES965_14760	COG0371	Dehydrogenase
ES965_14765	COG0647	UMP catabolic process
ES965_14770	COG0235	Class ii aldolase
ES965_14775	COG1069	ribulokinase activity
ES965_14780	COG2160	L-arabinose isomerase activity
ES965_14785	COG3507	Belongs to the glycosyl hydrolase 43 family
ES965_14790	COG1363	Peptidase, m42
ES965_14800	COG3326	Membrane
ES965_14805	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ES965_14810	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ES965_14815	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ES965_14825	COG1346	cytolysis
ES965_14830	COG1380	Effector of murein hydrolase LrgA
ES965_14835	COG3279	Response regulator of the LytR AlgR family
ES965_14840	COG3275	phosphorelay sensor kinase activity
ES965_14850	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ES965_14860	COG0398	Pfam SNARE associated Golgi protein
ES965_14865	COG1484	DNA-dependent DNA replication
ES965_14870	COG3611	Membrane attachment protein
ES965_14875	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ES965_14880	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ES965_14885	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ES965_14890	COG1733	regulation of RNA biosynthetic process
ES965_14895	COG2814	Major facilitator Superfamily
ES965_14900	COG0656	L-ascorbic acid biosynthetic process
ES965_14905	COG0237	dephospho-CoA kinase activity
ES965_14910	COG1971	Probably functions as a manganese efflux pump
ES965_14915	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ES965_14920	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES965_14920	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES965_14925	COG5002	protein histidine kinase activity
ES965_14930	COG0745	RESPONSE REGULATOR receiver
ES965_14935	COG0039	L-malate dehydrogenase activity
ES965_14940	COG0538	isocitrate dehydrogenase activity
ES965_14945	COG0372	Belongs to the citrate synthase family
ES965_14950	COG2707	UPF0756 membrane protein
ES965_14955	COG0628	permease
ES965_14960	COG3030	protein affecting phage T7 exclusion by the F plasmid
ES965_14965	COG0469	pyruvate kinase activity
ES965_14970	COG0205	6-phosphofructokinase activity
ES965_14975	COG0825	malonyl-CoA metabolic process
ES965_14980	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ES965_14985	COG0281	malic enzyme
ES965_14990	COG0587	DNA-directed DNA polymerase activity
ES965_15010	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ES965_15020	COG4109	DRTGG domain
ES965_15025	COG0730	response to heat
ES965_15030	COG1473	amidohydrolase
ES965_15035	COG0196	riboflavin kinase activity
ES965_15040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES965_15045	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
ES965_15050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES965_15055	COG1126	abc transporter atp-binding protein
ES965_15060	COG0765	amino acid transport
ES965_15065	COG0765	amino acid transport
ES965_15070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES965_15075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES965_15080	COG0454	-acetyltransferase
ES965_15085	COG0583	DNA-binding transcription factor activity
ES965_15090	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ES965_15095	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_15105	COG0165	Argininosuccinate lyase
ES965_15110	COG0137	argininosuccinate synthase activity
ES965_15115	COG0521	Mo-molybdopterin cofactor biosynthetic process
ES965_15120	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ES965_15130	COG0827	DNA restriction-modification system
ES965_15135	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ES965_15140	COG3874	Sporulation protein YtfJ
ES965_15150	COG1714	RDD family
ES965_15155	COG0616	signal peptide processing
ES965_15160	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ES965_15165	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ES965_15170	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ES965_15180	COG0301	tRNA thio-modification
ES965_15185	COG1104	cysteine desulfurase activity
ES965_15190	COG1114	Component of the transport system for branched-chain amino acids
ES965_15195	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ES965_15200	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ES965_15205	COG1309	transcriptional regulator
ES965_15210	COG1956	GAF domain-containing protein
ES965_15215	COG2203	Gaf domain
ES965_15215	COG2199	diguanylate cyclase activity
ES965_15225	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ES965_15230	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ES965_15235	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ES965_15240	COG0454	-acetyltransferase
ES965_15245	COG0517	IMP dehydrogenase activity
ES965_15250	COG0123	including yeast histone deacetylase and acetoin utilization protein
ES965_15255	COG1360	Flagellar Motor Protein
ES965_15260	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ES965_15265	COG1609	Transcriptional regulator
ES965_15270	COG1605	Chorismate mutase
ES965_15270	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ES965_15275	COG3118	belongs to the thioredoxin family
ES965_15280	COG4980	gas vesicle protein
ES965_15285	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ES965_15290	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ES965_15295	COG1674	ftsk spoiiie
ES965_15300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES965_15305	COG4848	Belongs to the UPF0354 family
ES965_15310	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES965_15325	COG1363	Peptidase, m42
ES965_15330	COG5584	Small secreted protein
ES965_15335	COG0281	malic enzyme
ES965_15340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES965_15345	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ES965_15355	COG0510	thiamine kinase activity
ES965_15360	COG1523	belongs to the glycosyl hydrolase 13 family
ES965_15365	COG1597	lipid kinase activity
ES965_15375	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ES965_15380	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES965_15385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES965_15390	COG2252	PERMEase
ES965_15395	COG4473	ABC transporter
ES965_15400	COG1131	(ABC) transporter
ES965_15405	COG1349	DNA-binding transcription factor activity
ES965_15410	COG1187	pseudouridine synthase activity
ES965_15415	COG2244	polysaccharide biosynthetic process
ES965_15420	COG2081	HI0933 family
ES965_15425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ES965_15435	COG5578	integral membrane protein
ES965_15440	COG0673	inositol 2-dehydrogenase activity
ES965_15445	COG1653	transport
ES965_15450	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ES965_15455	COG4209	transmembrane transport
ES965_15460	COG2207	Transcriptional regulator
ES965_15465	COG1653	transport
ES965_15470	COG0395	ABC-type sugar transport system, permease component
ES965_15475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES965_15480	COG2124	cytochrome p450
ES965_15485	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ES965_15495	COG0156	8-amino-7-oxononanoate synthase activity
ES965_15500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES965_15505	COG1424	Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP
ES965_15510	COG1073	alpha beta
ES965_15535	COG1486	melibiose metabolic process
ES965_15540	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ES965_15545	COG0495	leucyl-tRNA aminoacylation
ES965_15555	COG1366	Belongs to the anti-sigma-factor antagonist family
ES965_15555	COG2202	Pas domain
ES965_15560	COG2814	Major facilitator Superfamily
ES965_15565	COG2433	Pfam Transposase IS66
ES965_15570	COG0577	efflux transmembrane transporter activity
ES965_15575	COG1136	(ABC) transporter
ES965_15580	COG2205	protein histidine kinase activity
ES965_15585	COG0745	RESPONSE REGULATOR receiver
ES965_15590	COG0577	efflux transmembrane transporter activity
ES965_15595	COG1136	(ABC) transporter
ES965_15610	COG1131	(ABC) transporter
ES965_15615	COG1725	Transcriptional regulator
ES965_15630	COG1242	4 iron, 4 sulfur cluster binding
ES965_15635	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ES965_15645	COG2267	carboxylic ester hydrolase activity
ES965_15650	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ES965_15655	COG1113	amino acid transport
ES965_15660	COG0367	asparagine synthase
ES965_15665	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ES965_15670	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ES965_15680	COG1506	peptidase
ES965_15685	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ES965_15690	COG1116	anion transmembrane transporter activity
ES965_15695	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ES965_15700	COG0494	nUDIX hydrolase
ES965_15705	COG4824	toxin secretion phage lysis holin
ES965_15710	COG0783	Belongs to the Dps family
ES965_15725	COG1854	S-ribosylhomocysteine lyase activity
ES965_15730	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ES965_15735	COG0288	reversible hydration of carbon dioxide
ES965_15740	COG0254	rRNA binding
ES965_15745	COG1271	oxidase subunit
ES965_15750	COG1294	oxidase, subunit
ES965_15760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES965_15765	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES965_15765	COG1321	iron dependent repressor
ES965_15770	COG1121	(ABC) transporter
ES965_15775	COG0803	Belongs to the bacterial solute-binding protein 9 family
ES965_15780	COG4948	Mandelate Racemase Muconate Lactonizing
ES965_15785	COG0318	PFAM AMP-dependent synthetase and ligase
ES965_15790	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ES965_15795	COG0596	Alpha beta hydrolase
ES965_15800	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ES965_15805	COG1169	isochorismate synthase
ES965_15815	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES965_15820	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ES965_15825	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ES965_15830	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES965_15835	COG0438	transferase activity, transferring glycosyl groups
ES965_15845	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES965_15850	COG0438	transferase activity, transferring glycosyl groups
ES965_15855	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES965_15860	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ES965_15865	COG0058	SHG alpha-glucan phosphorylase activity
ES965_15870	COG0297	glycogen (starch) synthase activity
ES965_15875	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ES965_15880	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ES965_15885	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ES965_16010	COG3859	Proton-coupled thiamine transporter YuaJ
ES965_16015	COG1247	-acetyltransferase
ES965_16020	COG2268	Band 7 protein
ES965_16025	COG1585	Membrane protein implicated in regulation of membrane protease activity
ES965_16030	COG2318	DinB family
ES965_16040	COG1454	alcohol dehydrogenase
ES965_16050	COG1510	regulation of RNA biosynthetic process
ES965_16060	COG0569	domain protein
ES965_16065	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ES965_16070	COG4682	membrane
ES965_16075	COG1705	Flagellar rod assembly protein muramidase FlgJ
ES965_16080	COG0477	Major facilitator Superfamily
ES965_16085	COG5553	Cysteine dioxygenase type I
ES965_16095	COG1968	undecaprenyl-diphosphatase activity
ES965_16100	COG0628	permease
ES965_16105	COG0673	inositol 2-dehydrogenase activity
ES965_16110	COG4806	L-rhamnose isomerase
ES965_16115	COG3254	rhamnose metabolic process
ES965_16120	COG1070	Carbohydrate kinase
ES965_16125	COG1349	DNA-binding transcription factor activity
ES965_16130	COG3347	Dehydrogenase
ES965_16130	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_16140	COG0840	transmembrane signaling receptor activity
ES965_16145	COG0840	transmembrane signaling receptor activity
ES965_16150	COG0840	transmembrane signaling receptor activity
ES965_16155	COG0840	transmembrane signaling receptor activity
ES965_16170	COG0432	Pfam Uncharacterised protein family UPF0047
ES965_16180	COG0366	Alpha amylase catalytic
ES965_16185	COG1253	flavin adenine dinucleotide binding
ES965_16190	COG2738	Putative neutral zinc metallopeptidase
ES965_16205	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ES965_16220	COG0166	Belongs to the GPI family
ES965_16225	COG1979	alcohol dehydrogenase
ES965_16230	COG1979	alcohol dehydrogenase
ES965_16235	COG2155	Conserved Protein
ES965_16240	COG1098	S1 RNA binding domain
ES965_16245	COG0436	Aminotransferase
ES965_16250	COG1522	sequence-specific DNA binding
ES965_16255	COG2267	carboxylic ester hydrolase activity
ES965_16265	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ES965_16270	COG2205	protein histidine kinase activity
ES965_16280	COG5018	Exonuclease
ES965_16290	COG2814	Major facilitator Superfamily
ES965_16295	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES965_16300	COG3011	Protein conserved in bacteria
ES965_16310	COG3290	protein histidine kinase activity
ES965_16315	COG4565	transcriptional regulatory protein
ES965_16340	COG3493	citrate carrier protein
ES965_16350	COG2111	Na H antiporter
ES965_16350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ES965_16355	COG2111	Na H antiporter
ES965_16360	COG1006	Multisubunit Na H antiporter MnhC subunit
ES965_16365	COG0651	ATP synthesis coupled electron transport
ES965_16370	COG1863	multisubunit Na H antiporter MnhE subunit
ES965_16375	COG2212	antiporter activity
ES965_16380	COG1320	monovalent cation:proton antiporter activity
ES965_16385	COG2050	protein possibly involved in aromatic compounds catabolism
ES965_16390	COG2197	response regulator
ES965_16395	COG4585	Histidine kinase
ES965_16405	COG0142	geranyltranstransferase activity
ES965_16420	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ES965_16425	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ES965_16430	COG1335	isochorismatase
ES965_16435	COG5506	Protein of unknown function (DUF1694)
ES965_16450	COG0628	permease
ES965_16465	COG1418	mRNA catabolic process
ES965_16470	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_16480	COG1511	domain protein
ES965_16485	COG1674	ftsk spoiiie
ES965_16485	COG0433	COG0433 Predicted ATPase
ES965_16490	COG4499	WXG100 protein secretion system (Wss), protein YukC
ES965_16495	COG5417	Belongs to the EsaB family
ES965_16500	COG4842	Belongs to the WXG100 family
ES965_16510	COG2508	Transcriptional regulator
ES965_16510	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ES965_16515	COG0686	Belongs to the AlaDH PNT family
ES965_16520	COG5634	Uncharacterized conserved protein (DUF2278)
ES965_16525	COG3251	PFAM MbtH domain protein
ES965_16530	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_16535	COG3433	isochorismatase activity
ES965_16535	COG1535	isochorismatase
ES965_16540	COG1021	2,3-dihydroxybenzoate-AMP ligase
ES965_16545	COG1169	isochorismate synthase
ES965_16550	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_16555	COG2819	hydrolase of the alpha beta superfamily
ES965_16560	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ES965_16565	COG1268	BioY protein
ES965_16570	COG2056	Na+-H+ antiporter family
ES965_16575	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ES965_16580	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
ES965_16585	COG3584	3D domain protein
ES965_16600	COG1252	NADH dehydrogenase
ES965_16605	COG0492	ferredoxin-NADP+ reductase activity
ES965_16615	COG0516	GMP reductase activity
ES965_16620	COG2808	Putative FMN-binding domain
ES965_16625	COG0456	acetyltransferase
ES965_16630	COG0316	Belongs to the HesB IscA family
ES965_16635	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ES965_16640	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES965_16645	COG4844	belongs to the
ES965_16650	COG1252	NADH dehydrogenase
ES965_16655	COG4837	Protein of unknown function (DUF1462)
ES965_16660	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ES965_16665	COG1506	peptidase
ES965_16665	COG4946	Tricorn protease homolog
ES965_16665	COG0823	Involved in the tonB-independent uptake of proteins
ES965_16670	COG0083	homoserine kinase activity
ES965_16675	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ES965_16680	COG0460	homoserine dehydrogenase
ES965_16685	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES965_16690	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ES965_16695	COG0647	UMP catabolic process
ES965_16700	COG2445	Protein of unknown function DUF86
ES965_16705	COG4470	Protein conserved in bacteria
ES965_16715	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ES965_16720	COG0739	heme binding
ES965_16730	COG3377	Domain of unknown function (DUF1805)
ES965_16735	COG0737	Belongs to the 5'-nucleotidase family
ES965_16740	COG0730	response to heat
ES965_16745	COG1801	Protein of unknown function DUF72
ES965_16755	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ES965_16760	COG2508	Transcriptional regulator
ES965_16765	COG2233	PERMEase
ES965_16770	COG2233	PERMEase
ES965_16775	COG3195	allantoin biosynthetic process
ES965_16775	COG3648	Uricase
ES965_16780	COG2351	hydroxyisourate hydrolase activity
ES965_16790	COG2080	2 iron, 2 sulfur cluster binding
ES965_16795	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ES965_16800	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ES965_16805	COG2068	MobA-Related Protein
ES965_16810	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ES965_16815	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ES965_16820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES965_16830	COG2356	endonuclease I
ES965_16835	COG3842	ATPase activity
ES965_16840	COG2188	Transcriptional regulator
ES965_16845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES965_16850	COG0395	ABC-type sugar transport system, permease component
ES965_16855	COG1175	transmembrane transport
ES965_16860	COG1653	transport
ES965_16865	COG2222	sugar isomerase
ES965_16870	COG0322	excinuclease ABC activity
ES965_16875	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ES965_16890	COG0346	lactoylglutathione lyase activity
ES965_16895	COG0640	Transcriptional regulator
ES965_16900	COG0719	Fe-S assembly protein
ES965_16905	COG0822	iron-sulfur transferase activity
ES965_16910	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ES965_16915	COG0719	Fe-S assembly protein
ES965_16920	COG0396	ATPase activity
ES965_16935	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ES965_16940	COG1464	Belongs to the NlpA lipoprotein family
ES965_16945	COG2011	ABC-type metal ion transport system permease component
ES965_16950	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ES965_16960	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES965_16965	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ES965_16975	COG0509	glycine decarboxylation via glycine cleavage system
ES965_16980	COG1393	Belongs to the ArsC family
ES965_16985	COG1960	acyl-CoA dehydrogenase activity
ES965_16990	COG0183	Belongs to the thiolase family
ES965_16995	COG1024	Enoyl-CoA hydratase
ES965_16995	COG1250	3-hydroxyacyl-CoA dehydrogenase
ES965_17005	COG0506	proline dehydrogenase activity
ES965_17015	COG5577	PFAM Coat F domain
ES965_17025	COG0477	Major facilitator Superfamily
ES965_17030	COG1942	4-Oxalocrotonate Tautomerase
ES965_17035	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_17040	COG0583	DNA-binding transcription factor activity
ES965_17050	COG1120	ATPase activity
ES965_17065	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_17070	COG0783	Belongs to the Dps family
ES965_17075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES965_17080	COG0745	RESPONSE REGULATOR receiver
ES965_17085	COG2770	Histidine kinase
ES965_17085	COG2205	protein histidine kinase activity
ES965_17095	COG1309	transcriptional regulator
ES965_17100	COG0114	fumarate hydratase activity
ES965_17110	COG0697	spore germination
ES965_17115	COG0814	amino acid
ES965_17125	COG2197	response regulator
ES965_17130	COG4585	Histidine kinase
ES965_17135	COG4758	membrane
ES965_17140	COG3595	metallopeptidase activity
ES965_17145	COG1842	Phage shock protein A
ES965_17150	COG4758	membrane
ES965_17155	COG2814	Major facilitator Superfamily
ES965_17160	COG2096	Adenosyltransferase
ES965_17165	COG1120	ATPase activity
ES965_17170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES965_17175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES965_17180	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_17185	COG3386	PFAM SMP-30 Gluconolaconase
ES965_17190	COG2205	protein histidine kinase activity
ES965_17195	COG0745	RESPONSE REGULATOR receiver
ES965_17205	COG1191	sigma factor activity
ES965_17215	COG2140	Oxalate decarboxylase
ES965_17225	COG0577	efflux transmembrane transporter activity
ES965_17230	COG1136	(ABC) transporter
ES965_17235	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ES965_17240	COG1120	ATPase activity
ES965_17245	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES965_17250	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES965_17255	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES965_17260	COG0531	amino acid
ES965_17275	COG1988	membrane-bound metal-dependent
ES965_17280	COG1368	sulfuric ester hydrolase activity
ES965_17285	COG1910	domain protein
ES965_17290	COG0725	ABC transporter, periplasmic molybdate-binding protein
ES965_17295	COG4149	molybdate abc transporter
ES965_17300	COG0656	L-ascorbic acid biosynthetic process
ES965_17310	COG0025	NhaP-type Na H and K H
ES965_17315	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ES965_17320	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ES965_17325	COG3973	AAA domain
ES965_17335	COG2860	membrane
ES965_17340	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ES965_17345	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ES965_17350	COG2217	Heavy metal translocating P-type atpase
ES965_17355	COG2217	Heavy metal translocating P-type atpase
ES965_17360	COG2608	mercury ion transmembrane transporter activity
ES965_17365	COG1937	Protein conserved in bacteria
ES965_17370	COG0673	inositol 2-dehydrogenase activity
ES965_17375	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ES965_17380	COG1289	transmembrane transporter activity
ES965_17390	COG2076	Multidrug Resistance protein
ES965_17395	COG1309	transcriptional regulator
ES965_17400	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_17410	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ES965_17415	COG0557	exoribonuclease II activity
ES965_17420	COG1647	Serine aminopeptidase, S33
ES965_17425	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ES965_17430	COG0596	Alpha beta hydrolase
ES965_17435	COG1476	TRANSCRIPTIONal
ES965_17440	COG1396	sequence-specific DNA binding
ES965_17445	COG1396	sequence-specific DNA binding
ES965_17450	COG1733	regulation of RNA biosynthetic process
ES965_17475	COG1174	glycine betaine transport
ES965_17480	COG1732	Glycine betaine
ES965_17485	COG1174	glycine betaine transport
ES965_17490	COG1125	glycine betaine transport
ES965_17490	COG0517	IMP dehydrogenase activity
ES965_17495	COG1510	regulation of RNA biosynthetic process
ES965_17500	COG1174	glycine betaine transport
ES965_17505	COG1732	Glycine betaine
ES965_17510	COG1174	glycine betaine transport
ES965_17515	COG1125	glycine betaine transport
ES965_17515	COG0517	IMP dehydrogenase activity
ES965_17520	COG1510	regulation of RNA biosynthetic process
ES965_17525	COG2095	MarC family integral membrane protein
ES965_17535	COG3064	Membrane
ES965_17540	COG4640	response to antibiotic
ES965_17545	COG0456	acetyltransferase
ES965_17550	COG0148	phosphopyruvate hydratase activity
ES965_17555	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ES965_17560	COG0149	triose-phosphate isomerase activity
ES965_17565	COG0126	phosphoglycerate kinase activity
ES965_17570	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ES965_17575	COG2390	Transcriptional regulator
ES965_17580	COG2814	Major facilitator Superfamily
ES965_17585	COG1609	Transcriptional regulator
ES965_17590	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES965_17600	COG0583	DNA-binding transcription factor activity
ES965_17605	COG0697	spore germination
ES965_17610	COG1113	amino acid transport
ES965_17615	COG3858	chitin binding
ES965_17620	COG1556	Lactate utilization protein
ES965_17625	COG1139	Iron-sulfur cluster binding protein
ES965_17630	COG0247	lactate metabolic process
ES965_17635	COG2197	response regulator
ES965_17640	COG4585	Histidine kinase
ES965_17645	COG0842	Transport permease protein
ES965_17650	COG1131	(ABC) transporter
ES965_17655	COG0596	Alpha beta hydrolase
ES965_17660	COG2208	phosphoserine phosphatase activity
ES965_17665	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ES965_17670	COG1874	Beta-galactosidase
ES965_17675	COG3833	ABC-type maltose transport systems, permease component
ES965_17680	COG1175	transmembrane transport
ES965_17685	COG2182	Extracellular solute-binding protein
ES965_17690	COG1609	Transcriptional regulator
ES965_17695	COG2186	Transcriptional regulator
ES965_17700	COG1620	l-lactate permease
ES965_17705	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ES965_17715	COG5039	Polysaccharide pyruvyl transferase
ES965_17720	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES965_17725	COG0110	maltose O-acetyltransferase activity
ES965_17730	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ES965_17735	COG2244	polysaccharide biosynthetic process
ES965_17740	COG1216	Glycosyl transferase, family 2
ES965_17745	COG5039	Polysaccharide pyruvyl transferase
ES965_17750	COG1216	Glycosyl transferase, family 2
ES965_17760	COG0438	transferase activity, transferring glycosyl groups
ES965_17765	COG1215	transferase activity, transferring glycosyl groups
ES965_17770	COG0438	transferase activity, transferring glycosyl groups
ES965_17775	COG1086	Polysaccharide biosynthesis protein
ES965_17780	COG0489	protein tyrosine kinase activity
ES965_17785	COG3944	biosynthesis protein
ES965_17790	COG1396	sequence-specific DNA binding
ES965_17795	COG2272	Belongs to the type-B carboxylesterase lipase family
ES965_17805	COG3479	Phenolic acid decarboxylase
ES965_17815	COG1794	racemase activity, acting on amino acids and derivatives
ES965_17820	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ES965_17830	COG1621	beta-fructofuranosidase activity
ES965_17835	COG1621	beta-fructofuranosidase activity
ES965_17840	COG0531	amino acid
ES965_17845	COG1309	transcriptional regulator
ES965_17850	COG2076	Multidrug Resistance protein
ES965_17855	COG2076	Multidrug Resistance protein
ES965_17865	COG3621	Patatin-like phospholipase
ES965_17875	COG0740	serine-type endopeptidase activity
ES965_17880	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ES965_17885	COG0366	Alpha amylase catalytic
ES965_17890	COG1554	hydrolase, family 65, central catalytic
ES965_17895	COG5521	maltodextrose utilization protein MalA
ES965_17900	COG3833	ABC-type maltose transport systems, permease component
ES965_17905	COG1175	transmembrane transport
ES965_17910	COG2182	Extracellular solute-binding protein
ES965_17915	COG0366	Alpha amylase catalytic
ES965_17920	COG1609	Transcriptional regulator
ES965_17925	COG1611	Belongs to the LOG family
ES965_17930	COG1694	Mazg nucleotide pyrophosphohydrolase
ES965_17935	COG0659	secondary active sulfate transmembrane transporter activity
ES965_17940	COG0288	reversible hydration of carbon dioxide
ES965_17945	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ES965_17950	COG0577	efflux transmembrane transporter activity
ES965_17955	COG1136	(ABC) transporter
ES965_17960	COG5002	protein histidine kinase activity
ES965_17965	COG0745	RESPONSE REGULATOR receiver
ES965_17975	COG2162	N-hydroxyarylamine O-acetyltransferase activity
ES965_17980	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES965_17985	COG1481	regulation of sporulation
ES965_17990	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ES965_17995	COG1660	Displays ATPase and GTPase activities
ES965_18000	COG1051	belongs to the nudix hydrolase family
ES965_18005	COG0492	ferredoxin-NADP+ reductase activity
ES965_18010	COG3883	PFAM NLP P60 protein
ES965_18010	COG0791	NLP P60 protein
ES965_18015	COG0457	Tetratricopeptide repeat
ES965_18020	COG1132	(ABC) transporter
ES965_18040	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ES965_18040	COG0140	phosphoribosyl-ATP diphosphatase activity
ES965_18045	COG0107	imidazoleglycerol-phosphate synthase activity
ES965_18050	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ES965_18055	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ES965_18060	COG0131	Imidazoleglycerol-phosphate dehydratase
ES965_18065	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ES965_18070	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ES965_18075	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ES965_18080	COG4990	cell redox homeostasis
ES965_18085	COG5297	Belongs to the glycosyl hydrolase family 6
ES965_18090	COG0110	maltose O-acetyltransferase activity
ES965_18095	COG0546	phosphoglycolate phosphatase activity
ES965_18100	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ES965_18105	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ES965_18110	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ES965_18115	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ES965_18120	COG0363	glucosamine-6-phosphate deaminase activity
ES965_18130	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ES965_18135	COG1950	PFAM Membrane protein of
ES965_18140	COG1983	PspC domain protein
ES965_18145	COG3595	metallopeptidase activity
ES965_18160	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ES965_18165	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ES965_18170	COG0556	nucleotide-excision repair
ES965_18175	COG4897	Protein conserved in bacteria
ES965_18180	COG3848	Pyruvate phosphate dikinase
ES965_18180	COG0574	Belongs to the PEP-utilizing enzyme family
ES965_18185	COG1309	transcriptional regulator
ES965_18190	COG2814	Major facilitator Superfamily
ES965_18195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES965_18205	COG0793	Belongs to the peptidase S41A family
ES965_18205	COG3409	Peptidoglycan-binding domain 1 protein
ES965_18210	COG2177	Part of the ABC transporter FtsEX involved in
ES965_18215	COG2884	Cell division ATP-binding protein ftsE
ES965_18220	COG2010	Cytochrome c
ES965_18225	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES965_18235	COG0653	protein targeting
ES965_18240	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ES965_18255	COG1516	flagellar protein fliS
ES965_18260	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ES965_18265	COG1334	flagellar protein FlaG
ES965_18270	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ES965_18275	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ES965_18280	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ES965_18290	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ES965_18295	COG1256	bacterial-type flagellum assembly
ES965_18295	COG4786	Flagellar basal body rod
ES965_18300	COG3418	PFAM FlgN family protein
ES965_18305	COG2747	anti-sigma28 factor FlgM
ES965_18315	COG1040	competence protein
ES965_18325	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ES965_18330	COG1307	EDD domain protein, DegV family
ES965_18335	COG2197	response regulator
ES965_18340	COG4585	Histidine kinase
ES965_18345	COG1739	Uncharacterized protein family UPF0029
ES965_18350	COG1316	TRANSCRIPTIONal
ES965_18355	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ES965_18360	COG0438	transferase activity, transferring glycosyl groups
ES965_18365	COG1215	transferase activity, transferring glycosyl groups
ES965_18370	COG3206	protein involved in exopolysaccharide biosynthesis
ES965_18375	COG3307	-O-antigen
ES965_18380	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ES965_18385	COG0297	glycogen (starch) synthase activity
ES965_18385	COG0438	transferase activity, transferring glycosyl groups
ES965_18390	COG2244	polysaccharide biosynthetic process
ES965_18405	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES965_18405	COG2247	cell wall binding repeat
ES965_18410	COG2247	cell wall binding repeat
ES965_18410	COG2385	sporulation resulting in formation of a cellular spore
ES965_18420	COG1316	TRANSCRIPTIONal
ES965_18425	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ES965_18445	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ES965_18450	COG1134	teichoic acid transport
ES965_18455	COG1682	transport, permease protein
ES965_18470	COG1215	transferase activity, transferring glycosyl groups
ES965_18470	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES965_18475	COG0463	Glycosyl transferase, family 2
ES965_18520	COG4193	domain, Protein
ES965_18525	COG1482	cell wall glycoprotein biosynthetic process
ES965_18530	COG0697	spore germination
ES965_18535	COG0814	amino acid
ES965_18545	COG2814	Major facilitator Superfamily
ES965_18550	COG1316	TRANSCRIPTIONal
ES965_18555	COG0561	phosphatase activity
ES965_18560	COG0791	NLP P60 protein
ES965_18570	COG2843	Capsule synthesis protein
ES965_18580	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ES965_18585	COG1609	Transcriptional regulator
ES965_18590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES965_18595	COG1869	D-ribose catabolic process
ES965_18600	COG1129	ABC transporter
ES965_18605	COG1172	Belongs to the binding-protein-dependent transport system permease family
ES965_18610	COG1879	ABC-type sugar transport system periplasmic component
ES965_18615	COG3103	Sh3 type 3 domain protein
ES965_18625	COG2249	NAD(P)H dehydrogenase (quinone) activity
ES965_18630	COG3527	Alpha-acetolactate decarboxylase
ES965_18635	COG0028	Belongs to the TPP enzyme family
ES965_18640	COG0583	DNA-binding transcription factor activity
ES965_18645	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ES965_18660	COG5337	Spore coat protein CotH
ES965_18670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ES965_18680	COG0405	Gamma-glutamyltransferase
ES965_18685	COG1522	sequence-specific DNA binding
ES965_18690	COG2059	Chromate
ES965_18695	COG2059	Chromate
ES965_18705	COG0655	NAD(P)H dehydrogenase (quinone) activity
ES965_18710	COG0583	DNA-binding transcription factor activity
ES965_18740	COG5444	nuclease activity
ES965_18755	COG3878	Protein conserved in bacteria
ES965_18760	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ES965_18765	COG4464	protein tyrosine phosphatase activity
ES965_18770	COG0489	protein tyrosine kinase activity
ES965_18775	COG3944	biosynthesis protein
ES965_18785	COG4715	Zinc finger, swim domain protein
ES965_18790	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ES965_18795	COG0561	phosphatase activity
ES965_18800	COG1349	DNA-binding transcription factor activity
ES965_18805	COG0629	single-stranded DNA binding
ES965_18820	COG3764	Sortase (surface protein transpeptidase)
ES965_18830	COG3279	Response regulator of the LytR AlgR family
ES965_18835	COG0745	RESPONSE REGULATOR receiver
ES965_18835	COG2972	Histidine kinase
ES965_18840	COG1970	mechanosensitive ion channel activity
ES965_18845	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ES965_18850	COG0457	Tetratricopeptide repeat
ES965_18855	COG4786	Flagellar basal body rod
ES965_18860	COG4786	Flagellar basal body rod
ES965_18865	COG1077	Cell shape determining protein MreB Mrl
ES965_18870	COG1609	Transcriptional regulator
ES965_18880	COG1846	Transcriptional regulator
ES965_18885	COG2814	Major facilitator Superfamily
ES965_18895	COG3420	alginic acid biosynthetic process
ES965_18900	COG1953	Uracil, thiamine, allantoin
ES965_18905	COG0477	Major facilitator Superfamily
ES965_18910	COG1335	isochorismatase
ES965_18920	COG0004	ammonium transporteR
ES965_18925	COG0347	Belongs to the P(II) protein family
ES965_18930	COG0671	phosphoesterase, PA-phosphatase related
ES965_18940	COG0739	heme binding
ES965_18945	COG1247	-acetyltransferase
ES965_18965	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES965_18970	COG0789	Transcriptional regulator
ES965_18980	COG2910	NAD(P)H-binding
ES965_18985	COG1959	2 iron, 2 sulfur cluster binding
ES965_18990	COG0804	urea catabolic process
ES965_18995	COG0832	Belongs to the urease beta subunit family
ES965_19000	COG0831	urea catabolic process
ES965_19015	COG3237	CsbD-like
ES965_19020	COG1994	Peptidase M50
ES965_19025	COG0457	Tetratricopeptide repeat
ES965_19030	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ES965_19035	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ES965_19045	COG2304	oxidoreductase activity
ES965_19055	COG2304	oxidoreductase activity
ES965_19060	COG2385	sporulation resulting in formation of a cellular spore
ES965_19065	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ES965_19075	COG4836	Membrane
ES965_19085	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ES965_19090	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ES965_19095	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ES965_19100	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ES965_19105	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ES965_19110	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ES965_19115	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ES965_19120	COG0356	it plays a direct role in the translocation of protons across the membrane
ES965_19130	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ES965_19135	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ES965_19140	COG4475	Protein of unknown function (DUF436)
ES965_19145	COG0698	ribose 5-phosphate isomerase
ES965_19150	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ES965_19155	COG1971	Probably functions as a manganese efflux pump
ES965_19160	COG0009	L-threonylcarbamoyladenylate synthase
ES965_19165	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ES965_19185	COG2890	protein-(glutamine-N5) methyltransferase activity
ES965_19190	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ES965_19195	COG0346	lactoylglutathione lyase activity
ES965_19200	COG0789	Transcriptional regulator
ES965_19205	COG0679	Auxin Efflux Carrier
ES965_19210	COG0281	malic enzyme
ES965_19215	COG1435	thymidine kinase activity
ES965_19220	COG0254	rRNA binding
ES965_19225	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ES965_19235	COG1494	fructose-1,6-bisphosphatase
ES965_19240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ES965_19245	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ES965_19250	COG0191	fructose-bisphosphate aldolase activity
ES965_19255	COG2204	response regulator
ES965_19260	COG4821	SIS domain
ES965_19265	COG0504	CTP synthase activity
ES965_19270	COG3343	RNA polymerase activity
ES965_19275	COG1960	acyl-CoA dehydrogenase activity
ES965_19280	COG0247	lactate metabolic process
ES965_19280	COG2181	nitrate reductase activity
ES965_19285	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES965_19290	COG4294	response to UV
ES965_19300	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ES965_19305	COG1132	(ABC) transporter
ES965_19310	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES965_19320	COG2181	nitrate reductase activity
ES965_19325	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ES965_19330	COG1140	nitrate reductase beta subunit
ES965_19335	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ES965_19340	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ES965_19350	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ES965_19355	COG2223	nitrite transmembrane transporter activity
ES965_19360	COG0018	arginyl-trna synthetase
ES965_19365	COG4506	Protein conserved in bacteria
ES965_19380	COG0535	radical SAM domain protein
ES965_19390	COG1131	(ABC) transporter
ES965_19395	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ES965_19400	COG0612	Peptidase, M16
ES965_19405	COG0612	Peptidase, M16
ES965_19415	COG3391	amine dehydrogenase activity
ES965_19420	COG3391	amine dehydrogenase activity
ES965_19430	COG0457	Tetratricopeptide repeat
ES965_19460	COG1131	(ABC) transporter
ES965_19470	COG0010	Belongs to the arginase family
ES965_19475	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ES965_19480	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES965_19495	COG1994	Peptidase M50
ES965_19500	COG1942	4-Oxalocrotonate Tautomerase
ES965_19505	COG1846	Transcriptional regulator
ES965_19510	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ES965_19520	COG0477	Major facilitator Superfamily
ES965_19525	COG1959	2 iron, 2 sulfur cluster binding
ES965_19530	COG3465	dGTPase activity
ES965_19535	COG1078	dGTPase activity
ES965_19540	COG4844	belongs to the
ES965_19550	COG0697	spore germination
ES965_19555	COG0095	Lipoate-protein ligase
ES965_19560	COG0583	DNA-binding transcription factor activity
ES965_19565	COG0280	phosphate acetyltransferase
ES965_19575	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_19580	COG0436	Aminotransferase
ES965_19585	COG2814	Major facilitator Superfamily
ES965_19590	COG0151	Belongs to the GarS family
ES965_19595	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_19600	COG1917	Cupin 2, conserved barrel domain protein
ES965_19605	COG0077	Prephenate dehydratase
ES965_19610	COG2814	Major facilitator Superfamily
ES965_19615	COG0833	amino acid
ES965_19620	COG4187	Peptidase family M20/M25/M40
ES965_19625	COG1012	belongs to the aldehyde dehydrogenase family
ES965_19630	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES965_19640	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ES965_19645	COG1091	dTDP-4-dehydrorhamnose reductase activity
ES965_19650	COG1088	dTDP-glucose 4,6-dehydratase activity
ES965_19655	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ES965_19660	COG3980	spore coat polysaccharide biosynthesis protein
ES965_19665	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
ES965_19670	COG2089	acid synthase
ES965_19675	COG0456	acetyltransferase
ES965_19680	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES965_19685	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES965_19690	COG0463	Glycosyl transferase, family 2
ES965_19705	COG2363	Small membrane protein
ES965_19710	COG2233	PERMEase
ES965_19720	COG1012	belongs to the aldehyde dehydrogenase family
ES965_19725	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ES965_19730	COG1216	Glycosyl transferase, family 2
ES965_19735	COG0351	phosphomethylpyrimidine kinase
ES965_19745	COG1621	beta-fructofuranosidase activity
ES965_19750	COG1263	PTS System
ES965_19750	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES965_19755	COG2116	formate transmembrane transporter activity
ES965_19760	COG3711	transcriptional antiterminator
ES965_19770	COG1404	Belongs to the peptidase S8 family
ES965_19775	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES965_19780	COG0778	Nitroreductase
ES965_19785	COG0772	Belongs to the SEDS family
ES965_19795	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ES965_19800	COG1845	cytochrome c oxidase, subunit III
ES965_19805	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ES965_19810	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ES965_19815	COG2261	transglycosylase associated protein
ES965_19820	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ES965_19825	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ES965_19830	COG2246	polysaccharide biosynthetic process
ES965_19835	COG1309	transcriptional regulator
ES965_19845	COG3162	membrane
ES965_19850	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES965_19855	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ES965_19860	COG2837	iron assimilation
ES965_19865	COG2822	iron ion transport
ES965_19870	COG0672	)-iron permease
ES965_19875	COG0352	thiamine-phosphate diphosphorylase activity
ES965_19880	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ES965_19885	COG0583	DNA-binding transcription factor activity
ES965_19890	COG1380	Effector of murein hydrolase LrgA
ES965_19895	COG1346	cytolysis
ES965_19900	COG2814	Major facilitator Superfamily
ES965_19905	COG4895	conserved protein (DUF2196)
ES965_19910	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ES965_19915	COG0346	lactoylglutathione lyase activity
ES965_19925	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES965_19930	COG1404	Belongs to the peptidase S8 family
ES965_19935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES965_19935	COG1263	PTS System
ES965_19940	COG3711	transcriptional antiterminator
ES965_19945	COG1442	glycosyl transferase family 8
ES965_19950	COG5522	Integral membrane protein (intg_mem_TP0381)
ES965_19955	COG1846	Transcriptional regulator
ES965_19960	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ES965_19965	COG2234	aminopeptidase activity
ES965_19980	COG2814	Major facilitator Superfamily
ES965_19985	COG2357	RelA SpoT domain protein
ES965_19990	COG1575	Belongs to the MenA family. Type 1 subfamily
ES965_20010	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES965_20015	COG1696	Membrane protein involved in D-alanine export
ES965_20020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES965_20025	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ES965_20030	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
ES965_20035	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES965_20040	COG1486	melibiose metabolic process
ES965_20045	COG1447	Phosphotransferase system cellobiose-specific component IIA
ES965_20050	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES965_20055	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES965_20060	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES965_20060	COG3711	transcriptional antiterminator
ES965_20070	COG2094	Belongs to the DNA glycosylase MPG family
ES965_20075	COG0753	catalase activity
ES965_20080	COG2814	Major facilitator Superfamily
ES965_20085	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES965_20090	COG1131	(ABC) transporter
ES965_20110	COG1595	DNA-templated transcription, initiation
ES965_20115	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ES965_20120	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
ES965_20125	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ES965_20130	COG4988	ABC transporter
ES965_20135	COG1294	oxidase, subunit
ES965_20140	COG1271	oxidase subunit
ES965_20145	COG3493	citrate carrier protein
ES965_20150	COG0501	Belongs to the peptidase M48B family
ES965_20160	COG0726	polysaccharide deacetylase
ES965_20165	COG3842	ATPase activity
ES965_20170	COG2508	Transcriptional regulator
ES965_20175	COG1012	belongs to the aldehyde dehydrogenase family
ES965_20180	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES965_20190	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ES965_20200	COG4585	Histidine kinase
ES965_20205	COG2197	response regulator
ES965_20210	COG2195	Cleaves the N-terminal amino acid of tripeptides
ES965_20220	COG4894	glucomannan catabolic process
ES965_20225	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ES965_20230	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ES965_20235	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_20240	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ES965_20245	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ES965_20250	COG2610	gluconate transmembrane transporter activity
ES965_20255	COG0500	methyltransferase
ES965_20260	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES965_20275	COG0753	catalase activity
ES965_20275	COG0693	protein deglycase activity
ES965_20280	COG2851	Citrate transporter
ES965_20285	COG2273	Hydrolase Family 16
ES965_20290	COG3711	transcriptional antiterminator
ES965_20300	COG2270	Major facilitator Superfamily
ES965_20305	COG0513	Belongs to the DEAD box helicase family
ES965_20310	COG2755	lipolytic protein G-D-S-L family
ES965_20310	COG3401	FG-GAP repeat protein
ES965_20345	COG0697	spore germination
ES965_20350	COG0589	response to stress
ES965_20355	COG2723	6-phospho-beta-galactosidase activity
ES965_20360	COG1263	PTS System
ES965_20360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES965_20360	COG2190	(PTS) system
ES965_20370	COG5444	nuclease activity
ES965_20405	COG3507	Belongs to the glycosyl hydrolase 43 family
ES965_20430	COG2986	histidine ammonia-lyase
ES965_20435	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
ES965_20440	COG1228	amidohydrolase
ES965_20445	COG0010	Belongs to the arginase family
ES965_20450	COG0833	amino acid
ES965_20455	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ES965_20460	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES965_20465	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ES965_20470	COG2390	Transcriptional regulator
ES965_20480	COG3192	ethanolamine utilization protein
ES965_20485	COG2079	MmgE PrpD family protein
ES965_20495	COG1126	abc transporter atp-binding protein
ES965_20500	COG0765	amino acid transport
ES965_20505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES965_20525	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
ES965_20530	COG0561	phosphatase activity
ES965_20560	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES965_20565	COG5294	Protein conserved in bacteria
ES965_20570	COG0577	efflux transmembrane transporter activity
ES965_20575	COG1136	(ABC) transporter
ES965_20580	COG2205	protein histidine kinase activity
ES965_20585	COG0745	RESPONSE REGULATOR receiver
ES965_20590	COG0191	fructose-bisphosphate aldolase activity
ES965_20595	COG1082	Xylose isomerase domain protein TIM barrel
ES965_20600	COG1082	Xylose isomerase domain protein TIM barrel
ES965_20605	COG0673	inositol 2-dehydrogenase activity
ES965_20610	COG2814	Major facilitator Superfamily
ES965_20615	COG1082	Xylose isomerase domain protein TIM barrel
ES965_20620	COG3962	Belongs to the TPP enzyme family
ES965_20625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES965_20635	COG1012	belongs to the aldehyde dehydrogenase family
ES965_20640	COG1349	DNA-binding transcription factor activity
ES965_20645	COG0667	Aldo Keto reductase
ES965_20670	COG2814	Major facilitator Superfamily
ES965_20675	COG0326	Molecular chaperone. Has ATPase activity
ES965_20685	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_20690	COG1309	transcriptional regulator
ES965_20695	COG1012	belongs to the aldehyde dehydrogenase family
ES965_20705	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
ES965_20715	COG1714	RDD family
ES965_20720	COG2311	Membrane
ES965_20725	COG1917	Cupin 2, conserved barrel domain protein
ES965_20730	COG1309	transcriptional regulator
ES965_20735	COG1028	Short-chain dehydrogenase reductase Sdr
ES965_20740	COG1846	Transcriptional regulator
ES965_20745	COG1380	Effector of murein hydrolase LrgA
ES965_20750	COG1346	cytolysis
ES965_20755	COG5039	Polysaccharide pyruvyl transferase
ES965_20760	COG1929	Belongs to the glycerate kinase type-1 family
ES965_20765	COG1802	Transcriptional regulator
ES965_20770	COG1070	Carbohydrate kinase
ES965_20775	COG2610	gluconate transmembrane transporter activity
ES965_20780	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ES965_20785	COG0450	alkyl hydroperoxide reductase
ES965_20790	COG3634	alkyl hydroperoxide reductase activity
ES965_20800	COG2723	6-phospho-beta-galactosidase activity
ES965_20805	COG2190	(PTS) system
ES965_20810	COG1263	PTS System
ES965_20810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES965_20815	COG2188	Transcriptional regulator
ES965_20830	COG1131	(ABC) transporter
ES965_20835	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
ES965_20850	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ES965_20865	COG1063	alcohol dehydrogenase
ES965_20885	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
ES965_20890	COG0456	acetyltransferase
ES965_20895	COG0457	Tetratricopeptide repeat
ES965_20905	COG0010	Belongs to the arginase family
ES965_20910	COG0833	amino acid
ES965_20915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ES965_20920	COG3829	transcription factor binding
ES965_20925	COG5002	protein histidine kinase activity
ES965_20950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES965_20955	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ES965_20960	COG4853	Protein conserved in bacteria
ES965_20965	COG4863	YycH protein
ES965_20970	COG5002	protein histidine kinase activity
ES965_20975	COG0745	RESPONSE REGULATOR receiver
ES965_21005	COG0346	lactoylglutathione lyase activity
ES965_21010	COG0305	Participates in initiation and elongation during chromosome replication
ES965_21025	COG3093	addiction module antidote protein HigA
ES965_21030	COG2807	transmembrane transport
ES965_21035	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ES965_21040	COG0359	binds to the 23S rRNA
ES965_21045	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ES965_21050	COG4241	membrane
ES965_21060	COG5577	PFAM Coat F domain
ES965_21065	COG1733	regulation of RNA biosynthetic process
ES965_21070	COG1227	inorganic diphosphatase activity
ES965_21080	COG2271	Major facilitator Superfamily
ES965_21085	COG4978	Transcriptional regulator
ES965_21085	COG0789	Transcriptional regulator
ES965_21095	COG4319	ketosteroid isomerase
ES965_21100	COG1357	PFAM Pentapeptide repeats (8 copies)
ES965_21105	COG2814	Major facilitator Superfamily
ES965_21110	COG0583	DNA-binding transcription factor activity
ES965_21115	COG2153	protein acetylation
ES965_21130	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES965_21135	COG1846	Transcriptional regulator
ES965_21140	COG2153	protein acetylation
ES965_21145	COG2364	Membrane
ES965_21155	COG1331	Highly conserved protein containing a thioredoxin domain
ES965_21170	COG0640	Transcriptional regulator
ES965_21180	COG0789	Transcriptional regulator
ES965_21185	COG0697	spore germination
ES965_21190	COG1331	Highly conserved protein containing a thioredoxin domain
ES965_21195	COG1266	CAAX protease self-immunity
ES965_21200	COG2814	Major facilitator Superfamily
ES965_21200	COG0477	Major facilitator Superfamily
ES965_21205	COG0110	maltose O-acetyltransferase activity
ES965_21210	COG0346	lactoylglutathione lyase activity
ES965_21215	COG1609	Transcriptional regulator
ES965_21220	COG0708	Exodeoxyribonuclease III
ES965_21225	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ES965_21230	COG0629	single-stranded DNA binding
ES965_21235	COG0360	Binds together with S18 to 16S ribosomal RNA
ES965_21240	COG0012	GTP binding
ES965_21245	COG0243	molybdopterin cofactor binding
ES965_21250	COG4481	Protein conserved in bacteria
ES965_21255	COG3949	Membrane
ES965_21265	COG1475	DNA binding
ES965_21270	COG1192	Involved in chromosome partitioning
ES965_21280	COG1475	DNA binding
ES965_21285	COG0357	Ribosomal RNA small subunit methyltransferase G
ES965_21290	COG0445	tRNA wobble uridine modification
ES965_21295	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ES965_21300	COG1847	R3H domain protein
ES965_21305	COG0706	membrane insertase activity
ES965_21310	COG0594	ribonuclease P activity
ES965_21315	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ES965_21330	COG3953	SLT domain
ES965_21330	COG5280	Phage tail tape measure protein TP901
ES965_21365	COG3409	Peptidoglycan-binding domain 1 protein
ES965_21365	COG1388	LysM domain
ES965_21365	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES965_21395	COG1674	ftsk spoiiie
ES965_21460	COG1484	DNA-dependent DNA replication