locus-tag	class	description
ES968_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
ES968_00010	COG0592	DNA-directed DNA polymerase activity
ES968_00015	COG2501	S4 domain
ES968_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ES968_00030	COG0187	DNA topoisomerase II activity
ES968_00035	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ES968_00070	COG0517	IMP dehydrogenase activity
ES968_00070	COG0516	GMP reductase activity
ES968_00075	COG1686	Belongs to the peptidase S11 family
ES968_00080	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
ES968_00085	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
ES968_00090	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
ES968_00100	COG1428	Deoxynucleoside kinase
ES968_00105	COG1428	Deoxynucleoside kinase
ES968_00110	COG1388	LysM domain
ES968_00110	COG3858	chitin binding
ES968_00115	COG1335	isochorismatase
ES968_00120	COG0590	tRNA wobble adenosine to inosine editing
ES968_00130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
ES968_00135	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
ES968_00140	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
ES968_00185	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
ES968_00190	COG3853	Toxic anion resistance protein (TelA)
ES968_00195	COG1982	Orn Lys Arg decarboxylase major
ES968_00200	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
ES968_00205	COG3870	Protein conserved in bacteria
ES968_00210	COG1728	Protein conserved in bacteria
ES968_00215	COG0470	DNA polymerase III
ES968_00220	COG1774	PSP1 C-terminal conserved region
ES968_00225	COG4467	Involved in initiation control of chromosome replication
ES968_00230	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
ES968_00235	COG2827	Endonuclease containing a URI domain
ES968_00240	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
ES968_00245	COG2002	toxin-antitoxin pair type II binding
ES968_00250	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES968_00250	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES968_00255	COG0084	hydrolase, TatD family'
ES968_00260	COG3584	3D domain protein
ES968_00260	COG3583	domain protein
ES968_00265	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ES968_00270	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
ES968_00280	COG4466	Protein conserved in bacteria
ES968_00290	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
ES968_00295	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ES968_00300	COG0251	oxidation-reduction process
ES968_00305	COG2088	sporulation resulting in formation of a cellular spore
ES968_00310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
ES968_00315	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
ES968_00320	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
ES968_00325	COG0193	aminoacyl-tRNA hydrolase activity
ES968_00335	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
ES968_00340	COG2002	toxin-antitoxin pair type II binding
ES968_00345	COG2244	polysaccharide biosynthetic process
ES968_00350	COG3956	TIGRFAM MazG family protein
ES968_00355	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
ES968_00370	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
ES968_00375	COG1098	S1 RNA binding domain
ES968_00390	COG2208	phosphoserine phosphatase activity
ES968_00395	COG2304	oxidoreductase activity
ES968_00400	COG0515	serine threonine protein kinase
ES968_00405	COG0037	tRNA processing
ES968_00415	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
ES968_00420	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
ES968_00425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
ES968_00430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ES968_00435	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES968_00440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ES968_00445	COG0512	Glutamine amidotransferase of anthranilate synthase
ES968_00450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES968_00455	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
ES968_00460	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
ES968_00465	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
ES968_00470	COG1396	sequence-specific DNA binding
ES968_00475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ES968_00480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
ES968_00560	COG4463	regulation of RNA biosynthetic process
ES968_00565	COG3880	PFAM UvrB UvrC protein
ES968_00570	COG3869	Catalyzes the specific phosphorylation of arginine residues in
ES968_00575	COG0542	response to heat
ES968_00580	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
ES968_00585	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
ES968_00590	COG4956	integral membrane protein (PIN domain superfamily)
ES968_00595	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
ES968_00600	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
ES968_00605	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
ES968_00615	COG1045	serine acetyltransferase
ES968_00620	COG0215	cysteine-tRNA ligase activity
ES968_00625	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
ES968_00630	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ES968_00635	COG3688	RNA-binding protein containing a PIN domain
ES968_00640	COG1595	DNA-templated transcription, initiation
ES968_00645	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ES968_00650	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ES968_00655	COG0250	Participates in transcription elongation, termination and antitermination
ES968_00660	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
ES968_00665	COG0081	regulation of translation
ES968_00670	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
ES968_00675	COG0222	ribosome binding
ES968_00680	COG2813	Specifically methylates the guanine in position
ES968_00685	COG0085	RNA polymerase activity
ES968_00690	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
ES968_00695	COG1358	cellular component organization or biogenesis
ES968_00700	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
ES968_00705	COG0049	tRNA binding
ES968_00710	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
ES968_00715	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
ES968_00720	COG0596	Alpha beta hydrolase
ES968_00725	COG0051	transcription antitermination factor activity, RNA binding
ES968_00730	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
ES968_00735	COG0088	Forms part of the polypeptide exit tunnel
ES968_00740	COG0089	rRNA binding
ES968_00745	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
ES968_00750	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
ES968_00755	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
ES968_00760	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
ES968_00765	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
ES968_00770	COG0255	Belongs to the universal ribosomal protein uL29 family
ES968_00775	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
ES968_00780	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
ES968_00790	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
ES968_00800	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
ES968_00805	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
ES968_00810	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
ES968_00815	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
ES968_00820	COG1841	ribosomal large subunit assembly
ES968_00825	COG0200	Binds to the 23S rRNA
ES968_00830	COG0201	protein transport
ES968_00835	COG0563	adenylate kinase activity
ES968_00840	COG0024	Methionine aminopeptidase
ES968_00845	COG2163	COG2163 Ribosomal protein L14E L6E L27E
ES968_00850	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
ES968_00855	COG0257	Belongs to the bacterial ribosomal protein bL36 family
ES968_00860	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
ES968_00865	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
ES968_00870	COG0202	RNA polymerase activity
ES968_00875	COG0203	ribosomal protein L17
ES968_00880	COG1122	ATPase activity
ES968_00885	COG1122	ATPase activity
ES968_00890	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ES968_00895	COG0101	tRNA pseudouridine synthase activity
ES968_00900	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
ES968_00905	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
ES968_00910	COG2226	methyltransferase
ES968_00920	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES968_00925	COG0489	protein tyrosine kinase activity
ES968_00935	COG2194	sulfuric ester hydrolase activity
ES968_00940	COG0726	polysaccharide deacetylase
ES968_01025	COG0659	secondary active sulfate transmembrane transporter activity
ES968_01035	COG0385	Bile acid
ES968_01040	COG2819	hydrolase of the alpha beta superfamily
ES968_01045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES968_01050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES968_01055	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES968_01060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES968_01060	COG2207	Transcriptional regulator
ES968_01065	COG3876	Protein conserved in bacteria
ES968_01070	COG1472	Belongs to the glycosyl hydrolase 3 family
ES968_01075	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ES968_01080	COG1263	PTS System
ES968_01080	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES968_01085	COG1737	Transcriptional regulator
ES968_01090	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
ES968_01095	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES968_01100	COG1683	Conserved Protein
ES968_01130	COG1595	DNA-templated transcription, initiation
ES968_01135	COG5662	AntiSigma factor
ES968_01140	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ES968_01145	COG4856	YbbR-like protein
ES968_01150	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ES968_01155	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
ES968_01190	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ES968_01195	COG3002	Belongs to the UPF0753 family
ES968_01200	COG0288	reversible hydration of carbon dioxide
ES968_01210	COG5609	conserved protein (DUF2294)
ES968_01230	COG0515	serine threonine protein kinase
ES968_01245	COG1113	amino acid transport
ES968_01260	COG2602	Beta-lactamase
ES968_01265	COG2124	cytochrome p450
ES968_01275	COG0531	amino acid
ES968_01280	COG0584	glycerophosphoryl diester phosphodiesterase
ES968_01285	COG2271	Major facilitator Superfamily
ES968_01300	COG1846	Transcriptional regulator
ES968_01300	COG0456	acetyltransferase
ES968_01320	COG3409	Peptidoglycan-binding domain 1 protein
ES968_01325	COG0697	spore germination
ES968_01330	COG2207	Transcriptional regulator
ES968_01330	COG1917	Cupin 2, conserved barrel domain protein
ES968_01355	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
ES968_01360	COG3591	Belongs to the peptidase S1B family
ES968_01370	COG0596	Alpha beta hydrolase
ES968_01375	COG1183	phosphatidylcholine synthase activity
ES968_01380	COG0586	Pfam SNARE associated Golgi protein
ES968_01385	COG0688	phosphatidylethanolamine metabolic process
ES968_01395	COG2312	Erythromycin esterase
ES968_01400	COG2207	Transcriptional regulator
ES968_01410	COG1301	dicarboxylic acid transport
ES968_01415	COG2190	(PTS) system
ES968_01415	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES968_01415	COG1263	PTS System
ES968_01420	COG0363	glucosamine-6-phosphate deaminase activity
ES968_01435	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES968_01440	COG0833	amino acid
ES968_01445	COG2040	homocysteine
ES968_01455	COG1115	amino acid carrier protein
ES968_01460	COG2066	Belongs to the glutaminase family
ES968_01465	COG4191	Histidine kinase
ES968_01470	COG0784	Response regulator, receiver
ES968_01480	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ES968_01485	COG1012	belongs to the aldehyde dehydrogenase family
ES968_01490	COG2271	Major facilitator Superfamily
ES968_01495	COG4948	Mandelate Racemase Muconate Lactonizing
ES968_01500	COG2186	Transcriptional regulator
ES968_01520	COG0697	spore germination
ES968_01525	COG0745	RESPONSE REGULATOR receiver
ES968_01530	COG2205	protein histidine kinase activity
ES968_01535	COG1131	(ABC) transporter
ES968_01555	COG3773	Cell wall hydrolase
ES968_01560	COG2304	oxidoreductase activity
ES968_01570	COG3540	Alkaline phosphatase
ES968_01575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ES968_01580	COG0805	protein transport
ES968_01585	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
ES968_01590	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ES968_01595	COG0477	Major facilitator Superfamily
ES968_01600	COG1309	transcriptional regulator
ES968_01605	COG0252	asparaginase activity
ES968_01610	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ES968_01615	COG1714	RDD family
ES968_01620	COG1405	negative regulation of cell septum assembly
ES968_01620	COG3012	SEC-C Motif Domain Protein
ES968_01635	COG3279	Response regulator of the LytR AlgR family
ES968_01640	COG4555	ABC transporter
ES968_01645	COG1668	transmembrane transport
ES968_01650	COG0667	Aldo Keto reductase
ES968_01665	COG1595	DNA-templated transcription, initiation
ES968_01670	COG1595	DNA-templated transcription, initiation
ES968_01675	COG1876	peptidase activity
ES968_01680	COG0457	Tetratricopeptide repeat
ES968_01685	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_01690	COG0366	Alpha amylase catalytic
ES968_01695	COG0803	Belongs to the bacterial solute-binding protein 9 family
ES968_01700	COG1121	(ABC) transporter
ES968_01705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES968_01710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES968_01715	COG2310	stress, protein
ES968_01720	COG2310	stress, protein
ES968_01725	COG2310	stress, protein
ES968_01730	COG0861	Integral membrane protein TerC family
ES968_01740	COG3853	Toxic anion resistance protein (TelA)
ES968_01745	COG0477	Major facilitator Superfamily
ES968_01750	COG2814	Major facilitator Superfamily
ES968_01755	COG0640	Transcriptional regulator
ES968_01760	COG0517	IMP dehydrogenase activity
ES968_01760	COG4175	Glycine betaine
ES968_01765	COG4176	ABC-type proline glycine betaine transport system permease component
ES968_01770	COG2113	Glycine betaine
ES968_01775	COG1473	amidohydrolase
ES968_01780	COG1288	antiporter activity
ES968_01790	COG0366	Alpha amylase catalytic
ES968_01795	COG0039	L-malate dehydrogenase activity
ES968_01810	COG3403	YqcI/YcgG family
ES968_01820	COG3665	Urea carboxylase-associated protein
ES968_01825	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
ES968_01830	COG1660	Displays ATPase and GTPase activities
ES968_01840	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
ES968_01845	COG2226	methyltransferase
ES968_01850	COG0583	DNA-binding transcription factor activity
ES968_01855	COG3458	cephalosporin-C deacetylase activity
ES968_01860	COG3541	Predicted nucleotidyltransferase
ES968_01865	COG0506	proline dehydrogenase activity
ES968_01870	COG1012	belongs to the aldehyde dehydrogenase family
ES968_01875	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES968_01880	COG2508	Transcriptional regulator
ES968_01885	COG3689	TIGRFAM TIGR03943 family protein
ES968_01890	COG0701	Predicted permease
ES968_01895	COG2267	carboxylic ester hydrolase activity
ES968_01900	COG0492	ferredoxin-NADP+ reductase activity
ES968_01905	COG1587	Uroporphyrinogen-III synthase
ES968_01905	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ES968_01910	COG2146	nitrite reductase [NAD(P)H] activity
ES968_01915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ES968_01920	COG0243	molybdopterin cofactor binding
ES968_01925	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ES968_01930	COG2223	nitrite transmembrane transporter activity
ES968_01935	COG1469	GTP cyclohydrolase I activity
ES968_01940	COG1376	ErfK ybiS ycfS ynhG family protein
ES968_01950	COG0523	cobalamin synthesis protein
ES968_01955	COG0765	amino acid transport
ES968_01960	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES968_01980	COG1846	Transcriptional regulator
ES968_01990	COG3842	ATPase activity
ES968_01995	COG2723	6-phospho-beta-galactosidase activity
ES968_02005	COG3209	COG3209 Rhs family protein
ES968_02015	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
ES968_02020	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
ES968_02025	COG1733	regulation of RNA biosynthetic process
ES968_02030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES968_02035	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES968_02040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES968_02045	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
ES968_02050	COG2814	Major facilitator Superfamily
ES968_02060	COG0697	spore germination
ES968_02080	COG2364	Membrane
ES968_02085	COG1126	abc transporter atp-binding protein
ES968_02090	COG0765	amino acid transport
ES968_02095	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES968_02100	COG0583	DNA-binding transcription factor activity
ES968_02110	COG0596	Alpha beta hydrolase
ES968_02115	COG3104	oligopeptide transport
ES968_02120	COG5434	Belongs to the glycosyl hydrolase 28 family
ES968_02130	COG0697	spore germination
ES968_02140	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ES968_02145	COG1136	(ABC) transporter
ES968_02150	COG0577	efflux transmembrane transporter activity
ES968_02155	COG0745	RESPONSE REGULATOR receiver
ES968_02160	COG3850	Histidine kinase
ES968_02160	COG5002	protein histidine kinase activity
ES968_02165	COG0457	Tetratricopeptide repeat
ES968_02185	COG0527	aspartate kinase activity
ES968_02190	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES968_02195	COG4605	iron ion homeostasis
ES968_02200	COG4604	ABC transporter, ATP-binding protein
ES968_02205	COG4607	ABC-type enterochelin transport system periplasmic component
ES968_02215	COG2814	Major facilitator Superfamily
ES968_02220	COG1309	transcriptional regulator
ES968_02225	COG0778	Nitroreductase
ES968_02230	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
ES968_02235	COG0640	Transcriptional regulator
ES968_02240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES968_02245	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
ES968_02250	COG1012	belongs to the aldehyde dehydrogenase family
ES968_02255	COG4975	Glucose uptake
ES968_02260	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_02265	COG4549	nuclear export factor GLE1
ES968_02270	COG1276	copper resistance
ES968_02270	COG2372	response to copper ion
ES968_02275	COG1349	DNA-binding transcription factor activity
ES968_02285	COG2213	PTS system mannitol-specific
ES968_02290	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES968_02295	COG0246	Mannitol dehydrogenase
ES968_02300	COG0473	3-isopropylmalate dehydrogenase activity
ES968_02305	COG0681	Belongs to the peptidase S26 family
ES968_02315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ES968_02325	COG0561	phosphatase activity
ES968_02330	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
ES968_02335	COG1914	H( )-stimulated, divalent metal cation uptake system
ES968_02340	COG4336	lyase activity
ES968_02345	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
ES968_02350	COG1984	allophanate hydrolase subunit 2
ES968_02355	COG1414	Transcriptional regulator
ES968_02360	COG2755	lipolytic protein G-D-S-L family
ES968_02370	COG2329	Antibiotic biosynthesis monooxygenase
ES968_02375	COG0768	penicillin binding
ES968_02380	COG4989	oxidoreductase activity
ES968_02385	COG3711	transcriptional antiterminator
ES968_02390	COG0318	PFAM AMP-dependent synthetase and ligase
ES968_02395	COG2226	methyltransferase
ES968_02400	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_02405	COG1917	Cupin 2, conserved barrel domain protein
ES968_02410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES968_02415	COG3871	stress protein (general stress protein 26)
ES968_02425	COG2814	Major facilitator Superfamily
ES968_02430	COG1522	sequence-specific DNA binding
ES968_02435	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ES968_02435	COG0551	DNA topoisomerase type I activity
ES968_02440	COG0494	nUDIX hydrolase
ES968_02445	COG0028	Belongs to the TPP enzyme family
ES968_02475	COG1914	H( )-stimulated, divalent metal cation uptake system
ES968_02480	COG2261	transglycosylase associated protein
ES968_02485	COG4876	unkown
ES968_02490	COG2217	Heavy metal translocating P-type atpase
ES968_02495	COG3729	General stress protein
ES968_02500	COG0662	Cupin 2, conserved barrel domain protein
ES968_02505	COG2329	Antibiotic biosynthesis monooxygenase
ES968_02515	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
ES968_02520	COG3290	protein histidine kinase activity
ES968_02525	COG4565	transcriptional regulatory protein
ES968_02530	COG1301	dicarboxylic acid transport
ES968_02535	COG0628	permease
ES968_02540	COG1131	(ABC) transporter
ES968_02545	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES968_02555	COG1960	acyl-CoA dehydrogenase activity
ES968_02570	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES968_02575	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES968_02580	COG1181	Belongs to the D-alanine--D-alanine ligase family
ES968_02585	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
ES968_02595	COG0513	Belongs to the DEAD box helicase family
ES968_02600	COG3402	PFAM membrane-flanked domain
ES968_02605	COG3428	Bacterial PH domain
ES968_02610	COG0705	Rhomboid family
ES968_02615	COG0736	holo-[acyl-carrier-protein] synthase activity
ES968_02620	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
ES968_02625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ES968_02630	COG0864	Transcriptional regulator
ES968_02635	COG2337	Toxic component of a toxin-antitoxin (TA) module
ES968_02640	COG1366	Belongs to the anti-sigma-factor antagonist family
ES968_02645	COG1366	Belongs to the anti-sigma-factor antagonist family
ES968_02650	COG2172	sigma factor antagonist activity
ES968_02655	COG2208	phosphoserine phosphatase activity
ES968_02660	COG1366	Belongs to the anti-sigma-factor antagonist family
ES968_02665	COG2172	sigma factor antagonist activity
ES968_02670	COG1191	sigma factor activity
ES968_02675	COG2208	phosphoserine phosphatase activity
ES968_02680	COG2183	response to ionizing radiation
ES968_02690	COG3091	SprT-like family
ES968_02740	COG0583	DNA-binding transcription factor activity
ES968_02745	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES968_02755	COG5444	nuclease activity
ES968_02765	COG1476	TRANSCRIPTIONal
ES968_02790	COG0693	protein deglycase activity
ES968_02795	COG1278	Cold shock
ES968_02800	COG1329	Transcriptional regulator
ES968_02810	COG0697	spore germination
ES968_02815	COG1917	Cupin 2, conserved barrel domain protein
ES968_02815	COG2207	Transcriptional regulator
ES968_02820	COG0697	spore germination
ES968_02825	COG2207	Transcriptional regulator
ES968_02825	COG3708	Transcriptional regulator
ES968_02830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES968_02835	COG0477	Major facilitator Superfamily
ES968_02845	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
ES968_02860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES968_02865	COG1309	transcriptional regulator
ES968_02870	COG0697	spore germination
ES968_02875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES968_02880	COG2030	dehydratase
ES968_02885	COG3545	Serine hydrolase
ES968_02890	COG1733	regulation of RNA biosynthetic process
ES968_02895	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES968_02900	COG0640	Transcriptional regulator
ES968_02905	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ES968_02915	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES968_02920	COG0697	spore germination
ES968_02925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES968_02930	COG0076	glutamate decarboxylase activity
ES968_02935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ES968_02940	COG0640	Transcriptional regulator
ES968_02945	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ES968_02960	COG4585	Histidine kinase
ES968_02965	COG2197	response regulator
ES968_02970	COG2409	Drug exporters of the RND superfamily
ES968_02975	COG0596	Alpha beta hydrolase
ES968_02980	COG1811	Na channel or pump
ES968_02985	COG0789	Transcriptional regulator
ES968_02985	COG4978	Transcriptional regulator
ES968_02990	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES968_02995	COG0778	Nitroreductase
ES968_03000	COG0346	lactoylglutathione lyase activity
ES968_03005	COG2259	Doxx family
ES968_03010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES968_03025	COG2323	membrane
ES968_03030	COG2323	membrane
ES968_03035	COG0071	Belongs to the small heat shock protein (HSP20) family
ES968_03050	COG1309	transcriptional regulator
ES968_03060	COG0456	acetyltransferase
ES968_03070	COG1113	amino acid transport
ES968_03075	COG2318	DinB family
ES968_03080	COG1846	Transcriptional regulator
ES968_03085	COG2409	Drug exporters of the RND superfamily
ES968_03085	COG1033	growth of symbiont in host cell
ES968_03090	COG0778	Nitroreductase
ES968_03095	COG1846	Transcriptional regulator
ES968_03100	COG2814	Major facilitator Superfamily
ES968_03105	COG0730	response to heat
ES968_03110	COG1802	Transcriptional regulator
ES968_03115	COG3858	chitin binding
ES968_03115	COG1388	LysM domain
ES968_03120	COG1819	glycosyl
ES968_03130	COG1785	Belongs to the alkaline phosphatase family
ES968_03135	COG5646	InterPro IPR014922
ES968_03145	COG0454	-acetyltransferase
ES968_03150	COG1078	dGTPase activity
ES968_03155	COG1388	LysM domain
ES968_03160	COG2814	Major facilitator Superfamily
ES968_03165	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES968_03170	COG1447	Phosphotransferase system cellobiose-specific component IIA
ES968_03180	COG2723	6-phospho-beta-galactosidase activity
ES968_03185	COG2188	Transcriptional regulator
ES968_03190	COG1940	carbohydrate kinase activity
ES968_03195	COG1482	cell wall glycoprotein biosynthetic process
ES968_03200	COG4124	Belongs to the glycosyl hydrolase 26 family
ES968_03245	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
ES968_03250	COG0802	atpase or kinase
ES968_03255	COG1214	PFAM Peptidase M22, glycoprotease
ES968_03260	COG0456	acetyltransferase
ES968_03265	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
ES968_03275	COG0488	(ABC) transporter
ES968_03280	COG0315	cyclic pyranopterin monophosphate synthase activity
ES968_03285	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
ES968_03290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ES968_03295	COG0805	protein transport
ES968_03310	COG1266	CAAX protease self-immunity
ES968_03315	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
ES968_03320	COG0459	protein refolding
ES968_03335	COG0457	Tetratricopeptide repeat
ES968_03340	COG1063	alcohol dehydrogenase
ES968_03345	COG2211	Major facilitator Superfamily
ES968_03350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES968_03355	COG1842	Phage shock protein A
ES968_03360	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ES968_03365	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
ES968_03370	COG4260	virion core protein, lumpy skin disease virus
ES968_03380	COG2814	Major facilitator Superfamily
ES968_03385	COG1063	alcohol dehydrogenase
ES968_03390	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
ES968_03395	COG0823	Involved in the tonB-independent uptake of proteins
ES968_03415	COG2267	carboxylic ester hydrolase activity
ES968_03425	COG2132	Multicopper oxidase
ES968_03430	COG1113	amino acid transport
ES968_03440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
ES968_03445	COG0714	Associated with various cellular activities
ES968_03450	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
ES968_03455	COG1305	Transglutaminase-like
ES968_03460	COG0518	GMP synthase (glutamine-hydrolyzing) activity
ES968_03460	COG0519	Catalyzes the synthesis of GMP from XMP
ES968_03475	COG2252	PERMEase
ES968_03480	COG3064	Membrane
ES968_03490	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
ES968_03500	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
ES968_03505	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
ES968_03510	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
ES968_03515	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
ES968_03520	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ES968_03525	COG0047	phosphoribosylformylglycinamidine synthase activity
ES968_03530	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
ES968_03535	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
ES968_03540	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
ES968_03545	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
ES968_03550	COG0138	bifunctional purine biosynthesis protein purh
ES968_03555	COG0151	Belongs to the GarS family
ES968_03560	COG1522	sequence-specific DNA binding
ES968_03565	COG0531	amino acid
ES968_03575	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ES968_03580	COG1470	cell adhesion involved in biofilm formation
ES968_03585	COG4496	protein, YerC YecD
ES968_03590	COG0069	glutamate synthase activity
ES968_03595	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
ES968_03600	COG0210	DNA helicase
ES968_03605	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
ES968_03610	COG4851	CamS sex pheromone cAM373 precursor
ES968_03620	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES968_03625	COG1285	pathogenesis
ES968_03630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES968_03635	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ES968_03640	COG0154	amidase activity
ES968_03645	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
ES968_03650	COG1309	transcriptional regulator
ES968_03655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
ES968_03660	COG1597	lipid kinase activity
ES968_03665	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ES968_03730	COG5444	nuclease activity
ES968_03740	COG3586	endonuclease activity
ES968_03750	COG0457	Tetratricopeptide repeat
ES968_03760	COG0217	transcriptional regulatory protein
ES968_03770	COG1309	transcriptional regulator
ES968_03775	COG3631	Ketosteroid isomerase-related protein
ES968_03780	COG0702	epimerase
ES968_03795	COG3546	catalase activity
ES968_03800	COG0454	-acetyltransferase
ES968_03810	COG5578	integral membrane protein
ES968_03815	COG2972	Histidine kinase
ES968_03825	COG1653	transport
ES968_03830	COG1175	transmembrane transport
ES968_03835	COG0395	ABC-type sugar transport system, permease component
ES968_03840	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ES968_03845	COG2207	Transcriptional regulator
ES968_03850	COG2755	lipolytic protein G-D-S-L family
ES968_03860	COG5578	integral membrane protein
ES968_03870	COG3401	FG-GAP repeat protein
ES968_03875	COG2755	lipolytic protein G-D-S-L family
ES968_03890	COG1653	transport
ES968_03895	COG4209	transmembrane transport
ES968_03900	COG0395	ABC-type sugar transport system, permease component
ES968_03905	COG1486	melibiose metabolic process
ES968_03910	COG2323	membrane
ES968_03915	COG2329	Antibiotic biosynthesis monooxygenase
ES968_03920	COG0346	lactoylglutathione lyase activity
ES968_03935	COG5583	Uncharacterized small protein (DUF2292)
ES968_03940	COG0670	Belongs to the BI1 family
ES968_03945	COG0697	spore germination
ES968_03950	COG1846	Transcriptional regulator
ES968_03955	COG1846	Transcriptional regulator
ES968_03975	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ES968_03975	COG2124	cytochrome p450
ES968_03980	COG1368	sulfuric ester hydrolase activity
ES968_03985	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
ES968_03990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES968_03995	COG1442	glycosyl transferase family 8
ES968_04000	COG1216	Glycosyl transferase, family 2
ES968_04005	COG1442	glycosyl transferase family 8
ES968_04010	COG2223	nitrite transmembrane transporter activity
ES968_04015	COG1011	Hydrolase
ES968_04025	COG1012	belongs to the aldehyde dehydrogenase family
ES968_04030	COG0840	transmembrane signaling receptor activity
ES968_04035	COG0488	(ABC) transporter
ES968_04045	COG0789	Transcriptional regulator
ES968_04050	COG2814	Major facilitator Superfamily
ES968_04065	COG0488	(ABC) transporter
ES968_04070	COG0513	Belongs to the DEAD box helicase family
ES968_04075	COG0456	acetyltransferase
ES968_04080	COG2130	NADP-dependent
ES968_04085	COG1120	ATPase activity
ES968_04090	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES968_04095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES968_04100	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ES968_04115	COG3866	Pectate lyase
ES968_04120	COG0471	metal ion transport
ES968_04125	COG3290	protein histidine kinase activity
ES968_04130	COG4565	transcriptional regulatory protein
ES968_04135	COG3181	Tripartite tricarboxylate transporter family receptor
ES968_04140	COG2851	Citrate transporter
ES968_04145	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES968_04150	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
ES968_04155	COG1254	Belongs to the acylphosphatase family
ES968_04160	COG2258	MOSC domain
ES968_04180	COG0024	Methionine aminopeptidase
ES968_04185	COG1263	PTS System
ES968_04185	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES968_04190	COG1368	sulfuric ester hydrolase activity
ES968_04205	COG1115	amino acid carrier protein
ES968_04220	COG0697	spore germination
ES968_04230	COG0366	Alpha amylase catalytic
ES968_04235	COG2188	Transcriptional regulator
ES968_04240	COG0778	Nitroreductase
ES968_04245	COG0737	Belongs to the 5'-nucleotidase family
ES968_04250	COG0693	protein deglycase activity
ES968_04255	COG2814	Major facilitator Superfamily
ES968_04260	COG4840	Belongs to the UPF0435 family
ES968_04265	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ES968_04270	COG4980	gas vesicle protein
ES968_04275	COG1295	ribonuclease BN
ES968_04280	COG0477	Major facilitator Superfamily
ES968_04285	COG0387	Pfam Sodium calcium exchanger
ES968_04295	COG0668	transmembrane transport
ES968_04300	COG0535	radical SAM domain protein
ES968_04310	COG0726	polysaccharide deacetylase
ES968_04315	COG2084	Dehydrogenase
ES968_04320	COG0598	Magnesium transport protein CorA
ES968_04325	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
ES968_04330	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
ES968_04340	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
ES968_04345	COG4637	Psort location Cytoplasmic, score
ES968_04355	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES968_04360	COG0022	dehydrogenase e1 component
ES968_04365	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES968_04370	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES968_04375	COG3284	Transcriptional regulator
ES968_04385	COG1742	UPF0060 membrane protein
ES968_04410	COG4842	Belongs to the WXG100 family
ES968_04415	COG1486	melibiose metabolic process
ES968_04420	COG1737	Transcriptional regulator
ES968_04425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES968_04425	COG1263	PTS System
ES968_04430	COG5434	Belongs to the glycosyl hydrolase 28 family
ES968_04435	COG1132	(ABC) transporter
ES968_04440	COG1132	(ABC) transporter
ES968_04445	COG2259	Doxx family
ES968_04450	COG2514	catechol 2,3-dioxygenase activity
ES968_04455	COG4977	sequence-specific DNA binding
ES968_04455	COG1917	Cupin 2, conserved barrel domain protein
ES968_04460	COG2814	Major facilitator Superfamily
ES968_04465	COG1082	Xylose isomerase domain protein TIM barrel
ES968_04475	COG4585	Histidine kinase
ES968_04480	COG2197	response regulator
ES968_04485	COG1131	(ABC) transporter
ES968_04490	COG0842	Transport permease protein
ES968_04490	COG1511	domain protein
ES968_04495	COG0842	Transport permease protein
ES968_04500	COG1695	Transcriptional regulator
ES968_04505	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
ES968_04510	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
ES968_04515	COG1309	transcriptional regulator
ES968_04520	COG2814	Major facilitator Superfamily
ES968_04525	COG2318	DinB family
ES968_04535	COG1846	Transcriptional regulator
ES968_04540	COG0392	lysyltransferase activity
ES968_04540	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
ES968_04545	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES968_04555	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES968_04560	COG0384	phenazine biosynthesis protein PhzF
ES968_04565	COG0778	Nitroreductase
ES968_04580	COG1090	epimerase
ES968_04585	COG2137	regulation of response to DNA damage stimulus
ES968_04595	COG2814	Major facilitator Superfamily
ES968_04615	COG3103	Sh3 type 3 domain protein
ES968_04620	COG5658	integral membrane protein
ES968_04625	COG0596	Alpha beta hydrolase
ES968_04630	COG0463	Glycosyl transferase, family 2
ES968_04635	COG4485	Bacterial membrane protein, YfhO
ES968_04640	COG1988	membrane-bound metal-dependent
ES968_04645	COG1194	a g-specific adenine glycosylase
ES968_04655	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_04670	COG3557	Belongs to the UPF0374 family
ES968_04675	COG1132	(ABC) transporter
ES968_04680	COG4129	membrane
ES968_04685	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ES968_04690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
ES968_04695	COG0735	belongs to the Fur family
ES968_04810	COG4326	sporulation control protein
ES968_04820	COG5577	PFAM Coat F domain
ES968_04825	COG3340	Belongs to the peptidase S51 family
ES968_04830	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
ES968_04845	COG0753	catalase activity
ES968_04850	COG1116	anion transmembrane transporter activity
ES968_04855	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ES968_04860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ES968_04865	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES968_04875	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
ES968_04885	COG1476	TRANSCRIPTIONal
ES968_04895	COG3382	B3 4 domain protein
ES968_04900	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
ES968_04910	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
ES968_04920	COG0789	Transcriptional regulator
ES968_04925	COG1664	Polymer-forming cytoskeletal
ES968_04930	COG1664	Polymer-forming cytoskeletal
ES968_04935	COG2766	serine protein kinase
ES968_04940	COG2718	Belongs to the UPF0229 family
ES968_04945	COG1846	Transcriptional regulator
ES968_04950	COG1566	PFAM secretion protein HlyD family protein
ES968_04955	COG2814	Major facilitator Superfamily
ES968_04960	COG0655	NAD(P)H dehydrogenase (quinone) activity
ES968_04980	COG1725	Transcriptional regulator
ES968_04985	COG1131	(ABC) transporter
ES968_04990	COG1131	(ABC) transporter
ES968_04995	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES968_05000	COG1278	Cold shock
ES968_05010	COG1464	Belongs to the NlpA lipoprotein family
ES968_05015	COG3706	GGDEF domain
ES968_05020	COG1823	symporter activity
ES968_05025	COG5444	nuclease activity
ES968_05050	COG0582	viral genome integration into host DNA
ES968_05055	COG2946	Replication initiation factor
ES968_05105	COG5644	endopeptidase inhibitor activity
ES968_05110	COG0791	NLP P60 protein
ES968_05110	COG0741	lytic transglycosylase activity
ES968_05140	COG0457	Tetratricopeptide repeat
ES968_05160	COG5577	PFAM Coat F domain
ES968_05165	COG0737	Belongs to the 5'-nucleotidase family
ES968_05165	COG4085	toxin activity
ES968_05165	COG1525	nuclease
ES968_05170	COG3764	Sortase (surface protein transpeptidase)
ES968_05175	COG0564	pseudouridine synthase activity
ES968_05185	COG0517	IMP dehydrogenase activity
ES968_05190	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ES968_05195	COG3153	acetyltransferase
ES968_05195	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ES968_05200	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES968_05205	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
ES968_05210	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
ES968_05215	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
ES968_05220	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
ES968_05225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
ES968_05230	COG2203	Gaf domain
ES968_05230	COG4585	Histidine kinase
ES968_05235	COG2197	response regulator
ES968_05240	COG0431	NADPH-dependent FMN reductase
ES968_05255	COG0791	NLP P60 protein
ES968_05255	COG1388	LysM domain
ES968_05260	COG1959	2 iron, 2 sulfur cluster binding
ES968_05265	COG0668	transmembrane transport
ES968_05270	COG2719	SpoVR family
ES968_05275	COG1785	Belongs to the alkaline phosphatase family
ES968_05280	COG1388	LysM domain
ES968_05280	COG0791	NLP P60 protein
ES968_05285	COG0583	DNA-binding transcription factor activity
ES968_05290	COG0372	Belongs to the citrate synthase family
ES968_05295	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_05300	COG0531	amino acid
ES968_05305	COG0733	neurotransmitter:sodium symporter activity
ES968_05310	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES968_05315	COG0456	acetyltransferase
ES968_05330	COG1595	DNA-templated transcription, initiation
ES968_05335	COG0667	Aldo Keto reductase
ES968_05340	COG0204	Acyl-transferase
ES968_05345	COG1253	flavin adenine dinucleotide binding
ES968_05350	COG0789	Transcriptional regulator
ES968_05360	COG1253	flavin adenine dinucleotide binding
ES968_05365	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ES968_05370	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
ES968_05375	COG0584	glycerophosphoryl diester phosphodiesterase
ES968_05385	COG0668	transmembrane transport
ES968_05390	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
ES968_05395	COG0726	polysaccharide deacetylase
ES968_05400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES968_05405	COG1757	Na H antiporter
ES968_05410	COG0589	response to stress
ES968_05420	COG1132	(ABC) transporter
ES968_05425	COG1132	(ABC) transporter
ES968_05430	COG0702	epimerase
ES968_05450	COG0189	ligase activity
ES968_05455	COG0189	ligase activity
ES968_05460	COG4399	Belongs to the UPF0754 family
ES968_05465	COG3679	Belongs to the UPF0342 family
ES968_05470	COG4335	DNA alkylation repair
ES968_05475	COG0561	phosphatase activity
ES968_05480	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ES968_05485	COG0475	glutathione-regulated potassium exporter activity
ES968_05490	COG0490	domain, Protein
ES968_05500	COG1024	Enoyl-CoA hydratase
ES968_05510	COG4152	abc transporter atp-binding protein
ES968_05515	COG1668	transmembrane transport
ES968_05520	COG0420	3'-5' exonuclease activity
ES968_05525	COG4717	serine-type aminopeptidase activity
ES968_05530	COG3481	metal-dependent phosphohydrolase, HD sub domain
ES968_05540	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
ES968_05570	COG1846	Transcriptional regulator
ES968_05575	COG4980	gas vesicle protein
ES968_05590	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
ES968_05595	COG0537	adenosine 5'-monophosphoramidase activity
ES968_05600	COG1131	(ABC) transporter
ES968_05605	COG4473	ABC transporter
ES968_05615	COG1473	amidohydrolase
ES968_05620	COG3069	C4-dicarboxylate transmembrane transporter activity
ES968_05630	COG2329	Antibiotic biosynthesis monooxygenase
ES968_05635	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES968_05640	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
ES968_05655	COG1309	transcriptional regulator
ES968_05660	COG1511	domain protein
ES968_05665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES968_05670	COG4377	Putative membrane peptidase family (DUF2324)
ES968_05680	COG1363	Peptidase, m42
ES968_05685	COG4405	Protein conserved in bacteria
ES968_05690	COG1301	dicarboxylic acid transport
ES968_05700	COG1234	tRNA 3'-trailer cleavage
ES968_05705	COG0095	Lipoate-protein ligase
ES968_05710	COG0702	epimerase
ES968_05715	COG0318	PFAM AMP-dependent synthetase and ligase
ES968_05725	COG0501	Belongs to the peptidase M48B family
ES968_05735	COG0456	acetyltransferase
ES968_05740	COG0604	alcohol dehydrogenase
ES968_05745	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
ES968_05750	COG0406	alpha-ribazole phosphatase activity
ES968_05755	COG0183	Belongs to the thiolase family
ES968_05760	COG0318	PFAM AMP-dependent synthetase and ligase
ES968_05765	COG1268	BioY protein
ES968_05770	COG0840	transmembrane signaling receptor activity
ES968_05780	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_05790	COG4903	ComK protein
ES968_05795	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_05805	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES968_05820	COG0398	Pfam SNARE associated Golgi protein
ES968_05825	COG0681	Belongs to the peptidase S26 family
ES968_05830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
ES968_05835	COG1846	Transcriptional regulator
ES968_05845	COG0738	Major facilitator superfamily
ES968_05850	COG0673	inositol 2-dehydrogenase activity
ES968_05855	COG0561	phosphatase activity
ES968_05860	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES968_05865	COG1609	Transcriptional regulator
ES968_05870	COG3180	Ammonia monooxygenase
ES968_05875	COG0477	Major facilitator Superfamily
ES968_05875	COG2814	Major facilitator Superfamily
ES968_05880	COG4533	DNA binding
ES968_05890	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
ES968_05895	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
ES968_05900	COG1074	ATP-dependent DNA helicase activity
ES968_05905	COG0420	3'-5' exonuclease activity
ES968_05910	COG0419	ATPase involved in DNA repair
ES968_05915	COG1403	HNH endonuclease
ES968_05955	COG5337	Spore coat protein CotH
ES968_05960	COG0179	Fumarylacetoacetate (FAA) hydrolase
ES968_05970	COG1404	Belongs to the peptidase S8 family
ES968_05980	COG0367	asparagine synthase
ES968_05985	COG1562	ergosterol biosynthetic process
ES968_05990	COG0534	Mate efflux family protein
ES968_05995	COG2207	Transcriptional regulator
ES968_05995	COG1917	Cupin 2, conserved barrel domain protein
ES968_06000	COG1609	Transcriptional regulator
ES968_06005	COG0673	inositol 2-dehydrogenase activity
ES968_06010	COG2318	DinB family
ES968_06015	COG1279	arginine transmembrane transporter activity
ES968_06020	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
ES968_06025	COG1357	PFAM Pentapeptide repeats (8 copies)
ES968_06030	COG2267	carboxylic ester hydrolase activity
ES968_06040	COG2153	protein acetylation
ES968_06045	COG0646	methionine synthase
ES968_06045	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
ES968_06050	COG1666	GTP binding
ES968_06055	COG2996	Protein conserved in bacteria
ES968_06065	COG1307	EDD domain protein, DegV family
ES968_06070	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES968_06085	COG0561	phosphatase activity
ES968_06090	COG1073	alpha beta
ES968_06095	COG2151	metal-sulfur cluster biosynthetic enzyme
ES968_06105	COG0277	FAD linked oxidase domain protein
ES968_06110	COG2271	Major facilitator Superfamily
ES968_06115	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
ES968_06130	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ES968_06135	COG0505	Belongs to the CarA family
ES968_06140	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ES968_06145	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
ES968_06165	COG2267	carboxylic ester hydrolase activity
ES968_06175	COG1744	ABC transporter substrate-binding protein PnrA-like
ES968_06190	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES968_06195	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
ES968_06200	COG5504	Zn-dependent protease
ES968_06205	COG0444	Belongs to the ABC transporter superfamily
ES968_06210	COG4608	Belongs to the ABC transporter superfamily
ES968_06220	COG0601	transmembrane transport
ES968_06225	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES968_06235	COG0180	Tryptophanyl-tRNA synthetase
ES968_06240	COG4166	transmembrane transport
ES968_06245	COG0601	transmembrane transport
ES968_06250	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES968_06255	COG0444	Belongs to the ABC transporter superfamily
ES968_06260	COG4608	Belongs to the ABC transporter superfamily
ES968_06265	COG2814	Major facilitator Superfamily
ES968_06270	COG0456	acetyltransferase
ES968_06275	COG1393	Belongs to the ArsC family
ES968_06280	COG0861	Integral membrane protein TerC family
ES968_06290	COG4862	establishment of competence for transformation
ES968_06300	COG4469	Competence protein
ES968_06305	COG1164	Oligoendopeptidase f
ES968_06325	COG2346	COG2346, Truncated hemoglobins
ES968_06330	COG0741	lytic transglycosylase activity
ES968_06335	COG4116	CYTH
ES968_06345	COG2357	RelA SpoT domain protein
ES968_06350	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ES968_06355	COG0564	pseudouridine synthase activity
ES968_06360	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
ES968_06365	COG0475	glutathione-regulated potassium exporter activity
ES968_06365	COG0569	domain protein
ES968_06370	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
ES968_06375	COG0352	thiamine-phosphate diphosphorylase activity
ES968_06380	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ES968_06385	COG2104	thiamine diphosphate biosynthetic process
ES968_06390	COG2022	thiamine diphosphate biosynthetic process
ES968_06395	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ES968_06400	COG0351	phosphomethylpyrimidine kinase
ES968_06405	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
ES968_06460	COG0210	DNA helicase
ES968_06470	COG2153	protein acetylation
ES968_06475	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ES968_06480	COG2382	esterase
ES968_06485	COG0626	cystathionine gamma-synthase activity
ES968_06490	COG0626	cystathionine gamma-synthase activity
ES968_06495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES968_06500	COG5505	Protein of unknown function (DUF819)
ES968_06545	COG1396	sequence-specific DNA binding
ES968_06605	COG0457	Tetratricopeptide repeat
ES968_06610	COG5444	nuclease activity
ES968_06625	COG3328	transposase activity
ES968_06630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES968_06640	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
ES968_06660	COG0109	protoheme IX farnesyltransferase activity
ES968_06670	COG0726	polysaccharide deacetylase
ES968_06685	COG5504	Zn-dependent protease
ES968_06690	COG2205	protein histidine kinase activity
ES968_06705	COG2427	Protein of unknown function (DUF1641)
ES968_06715	COG1051	belongs to the nudix hydrolase family
ES968_06725	COG2124	cytochrome p450
ES968_06730	COG1819	glycosyl
ES968_06740	COG1587	Uroporphyrinogen-III synthase
ES968_06745	COG0390	transport system, permease component
ES968_06750	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES968_06755	COG0697	spore germination
ES968_06760	COG4297	protein containing double-stranded beta helix domain
ES968_06770	COG1252	NADH dehydrogenase
ES968_06775	COG1904	glucuronate isomerase
ES968_06780	COG2211	Major facilitator Superfamily
ES968_06785	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
ES968_06790	COG1063	alcohol dehydrogenase
ES968_06795	COG1312	Catalyzes the dehydration of D-mannonate
ES968_06800	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_06805	COG2271	Major facilitator Superfamily
ES968_06810	COG1609	Transcriptional regulator
ES968_06815	COG0246	Mannitol dehydrogenase
ES968_06820	COG2721	sulfolactate sulfo-lyase activity
ES968_06825	COG0730	response to heat
ES968_06830	COG2318	DinB family
ES968_06850	COG0457	Tetratricopeptide repeat
ES968_06865	COG3409	Peptidoglycan-binding domain 1 protein
ES968_06865	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES968_06865	COG1388	LysM domain
ES968_06875	COG4195	phage-related replication protein
ES968_06880	COG3546	catalase activity
ES968_06885	COG2856	Zn peptidase
ES968_06890	COG1396	sequence-specific DNA binding
ES968_06900	COG1522	sequence-specific DNA binding
ES968_06905	COG1484	DNA-dependent DNA replication
ES968_06925	COG1595	DNA-templated transcription, initiation
ES968_06930	COG3728	DNA packaging
ES968_06930	COG5484	DNA packaging
ES968_06935	COG1783	phage Terminase large subunit
ES968_06940	COG5518	Phage portal protein
ES968_06945	COG0338	D12 class N6 adenine-specific DNA methyltransferase
ES968_06950	COG4653	Phage capsid family
ES968_07000	COG3953	SLT domain
ES968_07000	COG5412	phage tail tape measure protein
ES968_07000	COG3953	SLT domain
ES968_07000	COG5412	phage tail tape measure protein
ES968_07000	COG5412	phage tail tape measure protein
ES968_07000	COG3953	SLT domain
ES968_07005	COG1652	LysM domain
ES968_07010	COG4193	domain, Protein
ES968_07020	COG3628	GPW Gp25 family protein
ES968_07025	COG3299	homolog of phage Mu protein gp47
ES968_07030	COG3778	Protein conserved in bacteria
ES968_07070	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES968_07070	COG3409	Peptidoglycan-binding domain 1 protein
ES968_07090	COG0306	phosphate transporter
ES968_07095	COG1392	Phosphate transport regulator
ES968_07100	COG0531	amino acid
ES968_07105	COG0346	lactoylglutathione lyase activity
ES968_07110	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ES968_07115	COG0463	Glycosyl transferase, family 2
ES968_07120	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES968_07125	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES968_07130	COG2362	D-Aminopeptidase
ES968_07135	COG0601	transmembrane transport
ES968_07140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
ES968_07145	COG0444	Belongs to the ABC transporter superfamily
ES968_07150	COG4166	transmembrane transport
ES968_07155	COG1619	proteins homologs of microcin C7 resistance protein MccF
ES968_07160	COG4948	Mandelate Racemase Muconate Lactonizing
ES968_07165	COG0791	NLP P60 protein
ES968_07170	COG4608	Belongs to the ABC transporter superfamily
ES968_07175	COG2706	6-phosphogluconolactonase activity
ES968_07180	COG1834	amidinotransferase
ES968_07185	COG1607	acyl-coa hydrolase
ES968_07190	COG1017	nitric oxide dioxygenase activity
ES968_07190	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
ES968_07200	COG2323	membrane
ES968_07205	COG2318	DinB family
ES968_07210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES968_07215	COG2076	Multidrug Resistance protein
ES968_07220	COG2076	Multidrug Resistance protein
ES968_07225	COG0788	formyltetrahydrofolate deformylase activity
ES968_07230	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ES968_07235	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
ES968_07240	COG1764	response to oxidative stress
ES968_07245	COG1846	Transcriptional regulator
ES968_07250	COG1764	response to oxidative stress
ES968_07260	COG0590	tRNA wobble adenosine to inosine editing
ES968_07265	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ES968_07270	COG1404	Belongs to the peptidase S8 family
ES968_07275	COG1366	Belongs to the anti-sigma-factor antagonist family
ES968_07280	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
ES968_07285	COG1122	ATPase activity
ES968_07290	COG4721	ABC-type cobalt transport system, permease component
ES968_07300	COG0745	RESPONSE REGULATOR receiver
ES968_07305	COG3850	Histidine kinase
ES968_07305	COG5002	protein histidine kinase activity
ES968_07315	COG3212	peptidase
ES968_07330	COG2239	Acts as a magnesium transporter
ES968_07335	COG0789	Transcriptional regulator
ES968_07350	COG1846	Transcriptional regulator
ES968_07355	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ES968_07360	COG0726	polysaccharide deacetylase
ES968_07365	COG1408	metallophosphoesterase
ES968_07375	COG0463	Glycosyl transferase, family 2
ES968_07380	COG1793	dna ligase
ES968_07380	COG3285	dna ligase
ES968_07385	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
ES968_07390	COG3300	MHYT domain
ES968_07390	COG5001	Diguanylate cyclase
ES968_07395	COG0586	Pfam SNARE associated Golgi protein
ES968_07400	COG0861	Integral membrane protein TerC family
ES968_07405	COG1191	sigma factor activity
ES968_07425	COG0501	Belongs to the peptidase M48B family
ES968_07430	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ES968_07445	COG3594	Acyltransferase
ES968_07450	COG5002	protein histidine kinase activity
ES968_07455	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
ES968_07465	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
ES968_07470	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
ES968_07475	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
ES968_07480	COG0436	Aminotransferase
ES968_07485	COG1850	ribulose-bisphosphate carboxylase activity
ES968_07490	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
ES968_07495	COG0235	Class ii aldolase
ES968_07500	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
ES968_07505	COG3339	Conserved Protein
ES968_07520	COG3852	Histidine kinase
ES968_07530	COG1846	Transcriptional regulator
ES968_07535	COG1360	Flagellar Motor Protein
ES968_07540	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ES968_07550	COG0542	response to heat
ES968_07555	COG3949	Membrane
ES968_07560	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
ES968_07565	COG0720	synthase
ES968_07570	COG0602	queuosine metabolic process
ES968_07575	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
ES968_07580	COG1733	regulation of RNA biosynthetic process
ES968_07585	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_07660	COG4873	Protein conserved in bacteria
ES968_07670	COG3773	Cell wall hydrolase
ES968_07675	COG2244	polysaccharide biosynthetic process
ES968_07680	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES968_07685	COG2217	Heavy metal translocating P-type atpase
ES968_07695	COG0006	proline dipeptidase activity
ES968_07700	COG1609	Transcriptional regulator
ES968_07705	COG3711	transcriptional antiterminator
ES968_07710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES968_07710	COG2190	(PTS) system
ES968_07710	COG1263	PTS System
ES968_07715	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES968_07720	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
ES968_07730	COG1533	DNA photolyase activity
ES968_07735	COG0456	acetyltransferase
ES968_07740	COG0840	transmembrane signaling receptor activity
ES968_07745	COG2084	Dehydrogenase
ES968_07750	COG3328	transposase activity
ES968_07755	COG2340	Cysteine-rich secretory protein family
ES968_07760	COG0768	penicillin binding
ES968_07765	COG4191	Histidine kinase
ES968_07770	COG0436	Aminotransferase
ES968_07780	COG0835	chemotaxis
ES968_07780	COG0784	Response regulator, receiver
ES968_07790	COG2814	Major facilitator Superfamily
ES968_07795	COG1376	ErfK ybiS ycfS ynhG family protein
ES968_07800	COG1408	metallophosphoesterase
ES968_07805	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_07810	COG2200	EAL domain
ES968_07815	COG4703	Protein of unknown function (DUF1797)
ES968_07820	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
ES968_07830	COG0517	IMP dehydrogenase activity
ES968_07835	COG0583	DNA-binding transcription factor activity
ES968_07840	COG0716	FMN binding
ES968_07850	COG0716	FMN binding
ES968_07855	COG2171	N-acyltransferase activity
ES968_07860	COG1473	amidohydrolase
ES968_07870	COG0668	transmembrane transport
ES968_07875	COG0450	alkyl hydroperoxide reductase
ES968_07880	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES968_07900	COG0746	molybdenum cofactor guanylyltransferase activity
ES968_07905	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ES968_07910	COG0303	'Molybdopterin
ES968_07915	COG1763	Mo-molybdopterin cofactor biosynthetic process
ES968_07920	COG0314	molybdopterin synthase activity
ES968_07925	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
ES968_07930	COG1132	(ABC) transporter
ES968_07935	COG1132	(ABC) transporter
ES968_07945	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ES968_07950	COG1136	(ABC) transporter
ES968_07955	COG0577	efflux transmembrane transporter activity
ES968_07960	COG1349	DNA-binding transcription factor activity
ES968_07965	COG1105	Belongs to the carbohydrate kinase PfkB family
ES968_07970	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES968_07970	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
ES968_07970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES968_07975	COG0681	Belongs to the peptidase S26 family
ES968_07985	COG0488	(ABC) transporter
ES968_07990	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ES968_07995	COG2309	aminopeptidase activity
ES968_08005	COG1077	Cell shape determining protein MreB Mrl
ES968_08010	COG2002	toxin-antitoxin pair type II binding
ES968_08015	COG3852	Histidine kinase
ES968_08025	COG0569	domain protein
ES968_08030	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
ES968_08035	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ES968_08045	COG0561	phosphatase activity
ES968_08050	COG0242	peptide deformylase activity
ES968_08060	COG0497	DNA recombination
ES968_08065	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES968_08070	COG0022	dehydrogenase e1 component
ES968_08075	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES968_08080	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES968_08085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES968_08095	COG1982	Orn Lys Arg decarboxylase major
ES968_08100	COG4476	Belongs to the UPF0223 family
ES968_08105	COG4493	Belongs to the UPF0637 family
ES968_08115	COG0483	inositol monophosphate 1-phosphatase activity
ES968_08125	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
ES968_08175	COG4896	Protein conserved in bacteria
ES968_08185	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
ES968_08190	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ES968_08195	COG2066	Belongs to the glutaminase family
ES968_08200	COG4838	Belongs to the UPF0358 family
ES968_08205	COG0772	Belongs to the SEDS family
ES968_08210	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
ES968_08215	COG1612	heme a metabolic process
ES968_08220	COG0109	protoheme IX farnesyltransferase activity
ES968_08225	COG2010	Cytochrome c
ES968_08225	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ES968_08230	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ES968_08235	COG1845	cytochrome c oxidase, subunit III
ES968_08240	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ES968_08245	COG3336	cytochrome c oxidase
ES968_08255	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
ES968_08260	COG2340	Cysteine-rich secretory protein family
ES968_08275	COG3679	Belongs to the UPF0342 family
ES968_08280	COG4471	UPF0298 protein
ES968_08285	COG0742	ribosomal rna small subunit methyltransferase
ES968_08290	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
ES968_08295	COG3314	Sporulation integral membrane protein YlbJ
ES968_08300	COG1752	Esterase of the alpha-beta hydrolase superfamily
ES968_08305	COG3480	Lon protease (S16) C-terminal proteolytic domain
ES968_08310	COG1323	Belongs to the UPF0348 family
ES968_08320	COG1399	metal-binding, possibly nucleic acid-binding protein
ES968_08325	COG0333	Belongs to the bacterial ribosomal protein bL32 family
ES968_08335	COG0454	-acetyltransferase
ES968_08340	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
ES968_08345	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
ES968_08350	COG2001	Belongs to the MraZ family
ES968_08355	COG0275	rRNA processing
ES968_08360	COG4839	cell division protein FtsL
ES968_08370	COG0768	penicillin binding
ES968_08375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
ES968_08380	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ES968_08385	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ES968_08390	COG0772	Belongs to the SEDS family
ES968_08395	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ES968_08400	COG0812	UDP-N-acetylmuramate dehydrogenase activity
ES968_08405	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
ES968_08410	COG3879	Bacterial protein of unknown function (DUF881)
ES968_08415	COG3879	Bacterial protein of unknown function (DUF881)
ES968_08420	COG3856	small basic protein
ES968_08425	COG0849	cell division
ES968_08430	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
ES968_08435	COG1404	Belongs to the peptidase S8 family
ES968_08435	COG4412	M6 family metalloprotease domain protein
ES968_08445	COG1191	sigma factor activity
ES968_08450	COG1191	sigma factor activity
ES968_08455	COG1119	ATPase activity
ES968_08460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES968_08465	COG1873	PFAM PRC-barrel domain
ES968_08475	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
ES968_08480	COG1799	cell septum assembly
ES968_08485	COG0762	integral membrane protein
ES968_08490	COG2302	S4 RNA-binding domain
ES968_08495	COG3599	regulation of cell shape
ES968_08500	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
ES968_08510	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES968_08515	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
ES968_08520	COG0564	pseudouridine synthase activity
ES968_08525	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
ES968_08530	COG2233	PERMEase
ES968_08535	COG0540	Belongs to the ATCase OTCase family
ES968_08540	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ES968_08545	COG0505	Belongs to the CarA family
ES968_08550	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
ES968_08555	COG0543	2 iron, 2 sulfur cluster binding
ES968_08560	COG0167	dihydroorotate dehydrogenase activity
ES968_08565	COG0284	orotidine-5'-phosphate decarboxylase activity
ES968_08570	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
ES968_08575	COG0175	sulfate reduction
ES968_08580	COG0306	phosphate transporter
ES968_08585	COG2046	Belongs to the sulfate adenylyltransferase family
ES968_08590	COG0529	Catalyzes the synthesis of activated sulfate
ES968_08595	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
ES968_08600	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
ES968_08605	COG1648	precorrin-2 dehydrogenase activity
ES968_08615	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ES968_08620	COG1561	YicC-like family, N-terminal region
ES968_08625	COG2052	Domain of unknown function (DUF370)
ES968_08630	COG0194	GDP metabolic process
ES968_08635	COG1758	RNA polymerase activity
ES968_08640	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ES968_08645	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
ES968_08650	COG0242	peptide deformylase activity
ES968_08655	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
ES968_08660	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ES968_08660	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
ES968_08665	COG0820	rRNA (adenine-C2-)-methyltransferase activity
ES968_08670	COG0631	protein serine/threonine phosphatase activity
ES968_08675	COG0515	serine threonine protein kinase
ES968_08675	COG2815	serine threonine protein kinase
ES968_08680	COG1162	GTPase activity
ES968_08685	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
ES968_08690	COG1564	THIamine pyrophosphokinase
ES968_08700	COG0227	Belongs to the bacterial ribosomal protein bL28 family
ES968_08705	COG1302	Protein conserved in bacteria
ES968_08710	COG1461	Dihydroxyacetone kinase
ES968_08715	COG1760	l-serine dehydratase
ES968_08720	COG1760	l-serine dehydratase
ES968_08725	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
ES968_08730	COG1349	DNA-binding transcription factor activity
ES968_08730	COG2050	protein possibly involved in aromatic compounds catabolism
ES968_08735	COG0416	fatty acid biosynthetic process
ES968_08740	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
ES968_08745	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_08750	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES968_08755	COG0571	ribonuclease III activity
ES968_08760	COG1196	nuclear chromosome segregation
ES968_08765	COG0552	protein localization to endoplasmic reticulum
ES968_08775	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
ES968_08780	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
ES968_08785	COG0228	four-way junction DNA binding
ES968_08790	COG1837	Belongs to the UPF0109 family
ES968_08800	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
ES968_08805	COG0336	Belongs to the RNA methyltransferase TrmD family
ES968_08810	COG0335	large ribosomal subunit rRNA binding
ES968_08815	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ES968_08820	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ES968_08830	COG2257	FlhB HrpN YscU SpaS Family
ES968_08835	COG0045	succinate-CoA ligase (ADP-forming) activity
ES968_08840	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
ES968_08845	COG0758	DNA mediated transformation
ES968_08850	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
ES968_08855	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
ES968_08860	COG4974	Belongs to the 'phage' integrase family
ES968_08865	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
ES968_08870	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
ES968_08875	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ES968_08880	COG1815	bacterial-type flagellum-dependent cell motility
ES968_08885	COG1558	bacterial-type flagellum-dependent cell motility
ES968_08890	COG1677	Flagellar hook-basal body complex protein FliE
ES968_08895	COG1766	The M ring may be actively involved in energy transduction
ES968_08900	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES968_08905	COG1317	bacterial-type flagellum organization
ES968_08910	COG1157	protein secretion by the type III secretion system
ES968_08915	COG2882	bacterial-type flagellum organization
ES968_08920	COG3334	PFAM MgtE intracellular
ES968_08925	COG3144	bacterial-type flagellum assembly
ES968_08930	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
ES968_08935	COG4786	Flagellar basal body rod
ES968_08940	COG1582	Flagellar protein (FlbD)
ES968_08945	COG1580	Controls the rotational direction of flagella during chemotaxis
ES968_08950	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES968_08955	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
ES968_08955	COG1776	CheC inhibitor of MCP methylation
ES968_08960	COG2201	protein-glutamate methylesterase activity
ES968_08965	COG3190	flagellar
ES968_08970	COG1338	Plays a role in the flagellum-specific transport system
ES968_08975	COG1987	bacterial-type flagellum assembly
ES968_08980	COG1684	flagellar biosynthetic protein fliR
ES968_08985	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ES968_08990	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
ES968_08995	COG1419	protein localization to endoplasmic reticulum
ES968_09000	COG0455	bacterial-type flagellum organization
ES968_09005	COG2201	protein-glutamate methylesterase activity
ES968_09010	COG2198	Histidine kinase
ES968_09010	COG0643	Histidine kinase
ES968_09015	COG0835	chemotaxis
ES968_09020	COG1776	CheC inhibitor of MCP methylation
ES968_09025	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
ES968_09030	COG1191	sigma factor activity
ES968_09040	COG0052	Belongs to the universal ribosomal protein uS2 family
ES968_09045	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
ES968_09050	COG0528	UMP kinase activity
ES968_09055	COG0233	cytoplasmic translational termination
ES968_09060	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
ES968_09065	COG4589	Belongs to the CDS family
ES968_09070	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
ES968_09075	COG0750	zinc metalloprotease
ES968_09080	COG0442	prolyl-tRNA aminoacylation
ES968_09085	COG2176	DNA-directed DNA polymerase activity
ES968_09090	COG0779	Required for maturation of 30S ribosomal subunits
ES968_09095	COG0195	Participates in both transcription termination and antitermination
ES968_09100	COG2740	Nucleic-acid-binding protein implicated in transcription termination
ES968_09105	COG1358	cellular component organization or biogenesis
ES968_09110	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
ES968_09115	COG1550	Protein conserved in bacteria
ES968_09120	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
ES968_09125	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
ES968_09130	COG0196	riboflavin kinase activity
ES968_09135	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
ES968_09140	COG1185	polyribonucleotide nucleotidyltransferase activity
ES968_09145	COG0726	polysaccharide deacetylase
ES968_09150	COG0612	Peptidase, M16
ES968_09155	COG1873	PFAM PRC-barrel domain
ES968_09160	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ES968_09165	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
ES968_09170	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
ES968_09175	COG0527	aspartate kinase activity
ES968_09180	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
ES968_09185	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
ES968_09190	COG0740	serine-type endopeptidase activity
ES968_09200	COG1674	ftsk spoiiie
ES968_09200	COG4980	gas vesicle protein
ES968_09205	COG2188	Transcriptional regulator
ES968_09210	COG2814	Major facilitator Superfamily
ES968_09215	COG0612	Peptidase, M16
ES968_09220	COG0612	Peptidase, M16
ES968_09225	COG0300	oxidoreductase activity
ES968_09240	COG1426	Protein conserved in bacteria
ES968_09245	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
ES968_09250	COG1058	Belongs to the CinA family
ES968_09250	COG1546	Belongs to the CinA family
ES968_09255	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
ES968_09260	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
ES968_09265	COG1418	mRNA catabolic process
ES968_09270	COG1692	metallophosphoesterase
ES968_09275	COG2359	stage V sporulation protein S
ES968_09280	COG1063	alcohol dehydrogenase
ES968_09285	COG0156	8-amino-7-oxononanoate synthase activity
ES968_09290	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ES968_09295	COG4550	Control of competence regulator ComK, YlbF/YmcA
ES968_09305	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
ES968_09310	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
ES968_09380	COG3328	transposase activity
ES968_09400	COG3226	Transcriptional regulator
ES968_09410	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES968_09415	COG1404	Belongs to the peptidase S8 family
ES968_09425	COG4195	phage-related replication protein
ES968_09430	COG1764	response to oxidative stress
ES968_09435	COG2076	Multidrug Resistance protein
ES968_09440	COG2076	Multidrug Resistance protein
ES968_09455	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
ES968_09460	COG1923	regulation of RNA biosynthetic process
ES968_09475	COG1780	Probably involved in ribonucleotide reductase function
ES968_09480	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES968_09485	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
ES968_09490	COG4112	unkown
ES968_09495	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES968_09505	COG0464	growth
ES968_09510	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
ES968_09515	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
ES968_09520	COG0789	Transcriptional regulator
ES968_09525	COG0174	glutamine synthetase
ES968_09535	COG3328	transposase activity
ES968_09550	COG5444	nuclease activity
ES968_09590	COG4282	regulation of fungal-type cell wall biogenesis
ES968_09605	COG3328	transposase activity
ES968_09615	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES968_09630	COG3655	Transcriptional regulator
ES968_09655	COG0135	phosphoribosylanthranilate isomerase activity
ES968_09660	COG2211	Major facilitator Superfamily
ES968_09665	COG3507	Belongs to the glycosyl hydrolase 43 family
ES968_09670	COG1940	carbohydrate kinase activity
ES968_09675	COG2115	Belongs to the xylose isomerase family
ES968_09680	COG1070	Carbohydrate kinase
ES968_09690	COG1525	nuclease
ES968_09695	COG2814	Major facilitator Superfamily
ES968_09700	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
ES968_09715	COG0756	dUTP diphosphatase activity
ES968_09755	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
ES968_09765	COG3832	glyoxalase III activity
ES968_09810	COG4195	phage-related replication protein
ES968_09820	COG0346	lactoylglutathione lyase activity
ES968_09830	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
ES968_09835	COG1388	LysM domain
ES968_09840	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
ES968_09845	COG4224	UPF0291 protein
ES968_09850	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
ES968_09860	COG3763	UPF0154 protein
ES968_09870	COG0785	Cytochrome C biogenesis protein
ES968_09875	COG2201	protein-glutamate methylesterase activity
ES968_09880	COG4846	Membrane protein involved in cytochrome C biogenesis
ES968_09890	COG0071	Belongs to the small heat shock protein (HSP20) family
ES968_09905	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
ES968_09910	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES968_09930	COG0824	Thioesterase
ES968_09940	COG4841	protein insertion into membrane
ES968_09945	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
ES968_09950	COG1832	CoA-binding protein
ES968_09955	COG0187	DNA topoisomerase II activity
ES968_09960	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
ES968_09970	COG1115	amino acid carrier protein
ES968_09975	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
ES968_09985	COG5520	Belongs to the glycosyl hydrolase 30 family
ES968_09995	COG2246	polysaccharide biosynthetic process
ES968_10000	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ES968_10005	COG0586	Pfam SNARE associated Golgi protein
ES968_10010	COG2404	hydrolase activity, acting on ester bonds
ES968_10015	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ES968_10020	COG1024	Enoyl-CoA hydratase
ES968_10025	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ES968_10030	COG0511	ligase activity, forming carbon-carbon bonds
ES968_10035	COG0439	Biotin carboxylase
ES968_10040	COG0318	PFAM AMP-dependent synthetase and ligase
ES968_10045	COG1960	acyl-CoA dehydrogenase activity
ES968_10055	COG1649	PFAM Uncharacterised BCR, COG1649
ES968_10065	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES968_10065	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
ES968_10070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES968_10075	COG2027	D-alanyl-D-alanine carboxypeptidase
ES968_10080	COG2017	converts alpha-aldose to the beta-anomer
ES968_10085	COG0534	Mate efflux family protein
ES968_10100	COG0582	viral genome integration into host DNA
ES968_10105	COG0166	Belongs to the GPI family
ES968_10110	COG0405	Gamma-glutamyltransferase
ES968_10115	COG0583	DNA-binding transcription factor activity
ES968_10120	COG0604	alcohol dehydrogenase
ES968_10125	COG0493	'glutamate synthase
ES968_10130	COG0067	glutamate synthase
ES968_10130	COG0069	glutamate synthase activity
ES968_10130	COG0070	glutamate synthase
ES968_10135	COG0583	DNA-binding transcription factor activity
ES968_10140	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
ES968_10145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES968_10155	COG0300	oxidoreductase activity
ES968_10160	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ES968_10170	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES968_10185	COG1131	(ABC) transporter
ES968_10195	COG2814	Major facilitator Superfamily
ES968_10205	COG3328	transposase activity
ES968_10285	COG3655	Transcriptional regulator
ES968_10330	COG0457	Tetratricopeptide repeat
ES968_10335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES968_10345	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
ES968_10370	COG2211	Major facilitator Superfamily
ES968_10375	COG3328	transposase activity
ES968_10405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
ES968_10425	COG5444	nuclease activity
ES968_10430	COG4282	regulation of fungal-type cell wall biogenesis
ES968_10435	COG1231	oxidoreductase activity
ES968_10440	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES968_10445	COG0662	Cupin 2, conserved barrel domain protein
ES968_10445	COG2207	Transcriptional regulator
ES968_10450	COG0456	acetyltransferase
ES968_10455	COG1309	transcriptional regulator
ES968_10460	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES968_10465	COG3708	Transcriptional regulator
ES968_10470	COG2378	regulation of single-species biofilm formation
ES968_10480	COG0640	Transcriptional regulator
ES968_10485	COG0741	lytic transglycosylase activity
ES968_10490	COG2322	membrane
ES968_10505	COG1619	proteins homologs of microcin C7 resistance protein MccF
ES968_10510	COG3239	Fatty acid desaturase
ES968_10515	COG4585	Histidine kinase
ES968_10520	COG2197	response regulator
ES968_10525	COG3584	3D domain protein
ES968_10525	COG1388	LysM domain
ES968_10530	COG0514	ATP-dependent DNA helicase (RecQ)
ES968_10540	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ES968_10545	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES968_10560	COG0071	Belongs to the small heat shock protein (HSP20) family
ES968_10585	COG1012	belongs to the aldehyde dehydrogenase family
ES968_10590	COG1657	PFAM Prenyltransferase squalene oxidase
ES968_10600	COG0733	neurotransmitter:sodium symporter activity
ES968_10605	COG0385	Bile acid
ES968_10610	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES968_10615	COG0567	Dehydrogenase, E1 component
ES968_10620	COG4548	von Willebrand factor, type A
ES968_10625	COG0714	Associated with various cellular activities
ES968_10630	COG2032	superoxide dismutase activity
ES968_10635	COG0791	NLP P60 protein
ES968_10635	COG1388	LysM domain
ES968_10640	COG1819	glycosyl
ES968_10645	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
ES968_10650	COG0534	Mate efflux family protein
ES968_10655	COG1366	Belongs to the anti-sigma-factor antagonist family
ES968_10660	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES968_10665	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES968_10695	COG1942	4-Oxalocrotonate Tautomerase
ES968_10700	COG1733	regulation of RNA biosynthetic process
ES968_10705	COG0778	Nitroreductase
ES968_10715	COG0400	carboxylic ester hydrolase activity
ES968_10720	COG0346	lactoylglutathione lyase activity
ES968_10730	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES968_10735	COG3409	Peptidoglycan-binding domain 1 protein
ES968_10735	COG0793	Belongs to the peptidase S41A family
ES968_10740	COG2226	methyltransferase
ES968_10750	COG1876	peptidase activity
ES968_10755	COG0813	purine-nucleoside phosphorylase activity
ES968_10770	COG0671	phosphoesterase, PA-phosphatase related
ES968_10795	COG4479	Belongs to the UPF0346 family
ES968_10805	COG1509	lysine 2,3-aminomutase activity
ES968_10810	COG0456	acetyltransferase
ES968_10815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES968_10820	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ES968_10825	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ES968_10830	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES968_10845	COG0456	acetyltransferase
ES968_10850	COG0463	Glycosyl transferase, family 2
ES968_10865	COG4641	Protein conserved in bacteria
ES968_10870	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
ES968_10875	COG1086	Polysaccharide biosynthesis protein
ES968_10880	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ES968_10885	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
ES968_10890	COG1846	Transcriptional regulator
ES968_10895	COG0534	Mate efflux family protein
ES968_10905	COG4698	Protein conserved in bacteria
ES968_10910	COG2755	lipolytic protein G-D-S-L family
ES968_10915	COG1999	signal sequence binding
ES968_10925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
ES968_10930	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ES968_10935	COG1272	protein, Hemolysin III
ES968_10940	COG0204	Acyl-transferase
ES968_10945	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ES968_10950	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ES968_10960	COG2136	Putative SAM-dependent methyltransferase
ES968_10960	COG2521	methyltransferase
ES968_10970	COG0129	dihydroxy-acid dehydratase activity
ES968_10975	COG1413	lyase activity
ES968_10980	COG1418	mRNA catabolic process
ES968_10985	COG0386	Belongs to the glutathione peroxidase family
ES968_10990	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
ES968_10995	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
ES968_11005	COG1278	Cold shock
ES968_11025	COG0328	RNA-DNA hybrid ribonuclease activity
ES968_11030	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
ES968_11035	COG0328	RNA-DNA hybrid ribonuclease activity
ES968_11045	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES968_11060	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ES968_11070	COG1755	Isoprenylcysteine carboxyl methyltransferase
ES968_11080	COG2233	PERMEase
ES968_11085	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ES968_11090	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
ES968_11100	COG0800	Aldolase
ES968_11105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES968_11110	COG1609	Transcriptional regulator
ES968_11115	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
ES968_11120	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_11125	COG1199	ATP-dependent helicase activity
ES968_11140	COG0116	Belongs to the methyltransferase superfamily
ES968_11155	COG4474	Belongs to the UPF0398 family
ES968_11170	COG3359	exonuclease
ES968_11175	COG1111	helicase
ES968_11175	COG1205	dead DEAH box helicase
ES968_11180	COG2190	(PTS) system
ES968_11185	COG0071	Belongs to the small heat shock protein (HSP20) family
ES968_11220	COG3331	DNA recombination
ES968_11225	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES968_11225	COG4499	WXG100 protein secretion system (Wss), protein YukC
ES968_11235	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
ES968_11240	COG3935	DnaD domain protein
ES968_11245	COG0017	Asparaginyl-tRNA synthetase
ES968_11250	COG0436	Aminotransferase
ES968_11255	COG5353	protein conserved in bacteria
ES968_11265	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
ES968_11265	COG1199	ATP-dependent helicase activity
ES968_11270	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
ES968_11275	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
ES968_11280	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
ES968_11285	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
ES968_11285	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
ES968_11290	COG0617	tRNA 3'-terminal CCA addition
ES968_11295	COG0438	transferase activity, transferring glycosyl groups
ES968_11300	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
ES968_11305	COG1803	Methylglyoxal synthase
ES968_11310	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
ES968_11315	COG1694	Mazg nucleotide pyrophosphohydrolase
ES968_11320	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES968_11330	COG4347	Protein of unknown function (DUF1405)
ES968_11335	COG2010	Cytochrome c
ES968_11335	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ES968_11340	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
ES968_11345	COG0723	plastoquinol--plastocyanin reductase activity
ES968_11355	COG5582	Belongs to the UPF0302 family
ES968_11360	COG0457	Tetratricopeptide repeat
ES968_11365	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
ES968_11370	COG0287	Prephenate dehydrogenase
ES968_11375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
ES968_11385	COG0133	tryptophan synthase activity
ES968_11390	COG0135	phosphoribosylanthranilate isomerase activity
ES968_11400	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
ES968_11405	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
ES968_11410	COG4401	Chorismate mutase type I
ES968_11415	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
ES968_11420	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
ES968_11425	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
ES968_11430	COG0105	UTP biosynthetic process
ES968_11435	COG0142	geranyltranstransferase activity
ES968_11440	COG2226	methyltransferase
ES968_11445	COG0142	geranyltranstransferase activity
ES968_11455	COG0302	gtp cyclohydrolase
ES968_11460	COG0776	regulation of translation
ES968_11465	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
ES968_11480	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
ES968_11485	COG1160	GTP binding
ES968_11510	COG1304	FMN binding
ES968_11515	COG0539	negative regulation of cytoplasmic translation
ES968_11520	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
ES968_11530	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
ES968_11535	COG2959	enzyme of heme biosynthesis
ES968_11540	COG3409	Peptidoglycan-binding domain 1 protein
ES968_11540	COG3773	Cell wall hydrolase
ES968_11545	COG2339	peptidase activity
ES968_11550	COG0492	ferredoxin-NADP+ reductase activity
ES968_11555	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES968_11560	COG4862	establishment of competence for transformation
ES968_11565	COG1408	metallophosphoesterase
ES968_11575	COG1388	LysM domain
ES968_11580	COG1266	CAAX protease self-immunity
ES968_11585	COG0514	ATP-dependent DNA helicase (RecQ)
ES968_11590	COG4955	Helix-turn-helix domain
ES968_11595	COG1141	Ferredoxin
ES968_11600	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
ES968_11605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
ES968_11610	COG0710	3-dehydroquinate dehydratase activity
ES968_11620	COG1595	DNA-templated transcription, initiation
ES968_11625	COG5002	protein histidine kinase activity
ES968_11630	COG0745	RESPONSE REGULATOR receiver
ES968_11635	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ES968_11640	COG1333	cytochrome c biogenesis protein
ES968_11645	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES968_11650	COG1187	pseudouridine synthase activity
ES968_11655	COG0700	Nucleoside recognition
ES968_11660	COG2715	membrane protein required for spore maturation
ES968_11665	COG1686	Belongs to the peptidase S11 family
ES968_11675	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
ES968_11680	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
ES968_11685	COG1547	Domain of unknown function (DUF309)
ES968_11690	COG0456	acetyltransferase
ES968_11695	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
ES968_11700	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ES968_11700	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
ES968_11705	COG0307	riboflavin synthase, alpha
ES968_11710	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ES968_11710	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
ES968_11720	COG0681	Belongs to the peptidase S26 family
ES968_11730	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
ES968_11780	COG3328	transposase activity
ES968_11785	COG3012	SEC-C Motif Domain Protein
ES968_11795	COG0457	Tetratricopeptide repeat
ES968_11850	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
ES968_11860	COG4086	secreted protein
ES968_11865	COG0019	diaminopimelate decarboxylase activity
ES968_11870	COG0697	spore germination
ES968_11885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
ES968_11905	COG1191	sigma factor activity
ES968_11910	COG2172	sigma factor antagonist activity
ES968_11915	COG1366	Belongs to the anti-sigma-factor antagonist family
ES968_11920	COG1686	Belongs to the peptidase S11 family
ES968_11925	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
ES968_11930	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
ES968_11935	COG4974	Belongs to the 'phage' integrase family
ES968_11945	COG0735	belongs to the Fur family
ES968_11950	COG1300	Membrane
ES968_11960	COG0281	malic enzyme
ES968_11965	COG1757	Na H antiporter
ES968_11970	COG1027	Aspartate ammonia-lyase
ES968_11975	COG0252	asparaginase activity
ES968_11980	COG1396	sequence-specific DNA binding
ES968_11985	COG1379	DNA repair
ES968_11990	COG0494	nUDIX hydrolase
ES968_12000	COG0667	Aldo Keto reductase
ES968_12010	COG1073	alpha beta
ES968_12020	COG4918	Iron-sulphur cluster biosynthesis
ES968_12025	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
ES968_12025	COG0456	acetyltransferase
ES968_12030	COG2329	Antibiotic biosynthesis monooxygenase
ES968_12035	COG0456	acetyltransferase
ES968_12045	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ES968_12055	COG2211	Major facilitator Superfamily
ES968_12060	COG0346	lactoylglutathione lyase activity
ES968_12065	COG1072	(Pantothenic acid kinase))
ES968_12070	COG3048	D-serine ammonia-lyase activity
ES968_12075	COG0300	oxidoreductase activity
ES968_12080	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES968_12085	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES968_12090	COG4187	Peptidase family M20/M25/M40
ES968_12095	COG1902	pentaerythritol trinitrate reductase activity
ES968_12100	COG0596	Alpha beta hydrolase
ES968_12110	COG1234	tRNA 3'-trailer cleavage
ES968_12115	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
ES968_12120	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ES968_12125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ES968_12135	COG0706	membrane insertase activity
ES968_12140	COG3361	conserved protein (COG2071)
ES968_12145	COG2195	Cleaves the N-terminal amino acid of tripeptides
ES968_12150	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
ES968_12155	COG0346	lactoylglutathione lyase activity
ES968_12160	COG1376	ErfK ybiS ycfS ynhG family protein
ES968_12165	COG4129	membrane
ES968_12170	COG1126	abc transporter atp-binding protein
ES968_12175	COG0765	amino acid transport
ES968_12180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES968_12190	COG1597	lipid kinase activity
ES968_12200	COG0789	Transcriptional regulator
ES968_12200	COG4978	Transcriptional regulator
ES968_12205	COG0508	dehydrogenase complex catalyzes the overall conversion of
ES968_12210	COG0022	dehydrogenase e1 component
ES968_12215	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
ES968_12220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
ES968_12225	COG3426	butyrate kinase activity
ES968_12230	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES968_12235	COG0280	phosphate acetyltransferase
ES968_12240	COG3829	transcription factor binding
ES968_12240	COG3290	protein histidine kinase activity
ES968_12250	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
ES968_12255	COG2079	MmgE PrpD family protein
ES968_12260	COG0372	Belongs to the citrate synthase family
ES968_12265	COG1960	acyl-CoA dehydrogenase activity
ES968_12270	COG1250	3-hydroxyacyl-CoA dehydrogenase
ES968_12275	COG0183	Belongs to the thiolase family
ES968_12280	COG0584	glycerophosphoryl diester phosphodiesterase
ES968_12285	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES968_12300	COG1902	pentaerythritol trinitrate reductase activity
ES968_12305	COG0745	RESPONSE REGULATOR receiver
ES968_12315	COG0750	zinc metalloprotease
ES968_12320	COG0497	DNA recombination
ES968_12325	COG1438	arginine binding
ES968_12330	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
ES968_12335	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
ES968_12340	COG0142	geranyltranstransferase activity
ES968_12345	COG1722	exodeoxyribonuclease VII activity
ES968_12350	COG1570	exodeoxyribonuclease VII activity
ES968_12355	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
ES968_12360	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
ES968_12365	COG1302	Protein conserved in bacteria
ES968_12370	COG0439	Biotin carboxylase
ES968_12375	COG0511	ligase activity, forming carbon-carbon bonds
ES968_12415	COG3854	ATPases associated with a variety of cellular activities
ES968_12425	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
ES968_12430	COG0006	proline dipeptidase activity
ES968_12435	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
ES968_12445	COG3872	metal-dependent enzyme
ES968_12455	COG1752	Esterase of the alpha-beta hydrolase superfamily
ES968_12460	COG1321	iron dependent repressor
ES968_12465	COG0095	Lipoate-protein ligase
ES968_12470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ES968_12475	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ES968_12480	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
ES968_12485	COG0404	The glycine cleavage system catalyzes the degradation of glycine
ES968_12490	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ES968_12505	COG1396	sequence-specific DNA binding
ES968_12515	COG0681	Belongs to the peptidase S26 family
ES968_12540	COG4940	Competence protein ComGF
ES968_12550	COG4970	Tfp pilus assembly protein FimT
ES968_12555	COG4537	Required for transformation and DNA binding
ES968_12560	COG1459	type II secretion system
ES968_12565	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
ES968_12570	COG0517	IMP dehydrogenase activity
ES968_12575	COG0598	Magnesium transport protein CorA
ES968_12580	COG1253	flavin adenine dinucleotide binding
ES968_12585	COG1366	Belongs to the anti-sigma-factor antagonist family
ES968_12595	COG1393	Belongs to the ArsC family
ES968_12605	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES968_12615	COG0011	TIGRFAM Protein of
ES968_12625	COG2866	Carboxypeptidase
ES968_12630	COG1368	sulfuric ester hydrolase activity
ES968_12635	COG1940	carbohydrate kinase activity
ES968_12640	COG4483	Protein conserved in bacteria
ES968_12645	COG0457	Tetratricopeptide repeat
ES968_12645	COG0705	Rhomboid family
ES968_12655	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
ES968_12660	COG0267	Belongs to the bacterial ribosomal protein bL33 family
ES968_12665	COG0438	transferase activity, transferring glycosyl groups
ES968_12680	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ES968_12685	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES968_12690	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
ES968_12695	COG0581	inorganic phosphate transmembrane transporter activity
ES968_12700	COG0573	inorganic phosphate transmembrane transporter activity
ES968_12705	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
ES968_12715	COG0477	Major facilitator Superfamily
ES968_12720	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
ES968_12725	COG2839	Protein conserved in bacteria
ES968_12730	COG5521	maltodextrose utilization protein MalA
ES968_12735	COG1388	LysM domain
ES968_12740	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
ES968_12745	COG4709	membrane
ES968_12750	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
ES968_12755	COG0735	belongs to the Fur family
ES968_12760	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES968_12770	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
ES968_12775	COG0513	Belongs to the DEAD box helicase family
ES968_12785	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
ES968_12790	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
ES968_12795	COG2384	SAM-dependent methyltransferase
ES968_12800	COG2010	Cytochrome c
ES968_12810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
ES968_12815	COG0358	DNA primase activity
ES968_12820	COG1671	Belongs to the UPF0178 family
ES968_12825	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
ES968_12830	COG0517	IMP dehydrogenase activity
ES968_12835	COG0751	glycine-tRNA ligase activity
ES968_12840	COG0752	glycyl-tRNA synthetase alpha subunit
ES968_12845	COG1381	Involved in DNA repair and RecF pathway recombination
ES968_12855	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
ES968_12860	COG0295	cytidine deaminase activity
ES968_12865	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
ES968_12870	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
ES968_12875	COG1480	7TM receptor with intracellular HD hydrolase
ES968_12880	COG1702	phosphate starvation-inducible protein PhoH
ES968_12885	COG0561	phosphatase activity
ES968_12900	COG4864	UPF0365 protein
ES968_12905	COG1030	water channel activity
ES968_12910	COG1610	YqeY-like protein
ES968_12915	COG0828	Belongs to the bacterial ribosomal protein bS21 family
ES968_12920	COG1283	sodium-dependent phosphate transmembrane transporter activity
ES968_12925	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
ES968_12930	COG1385	rRNA (uridine-N3-)-methyltransferase activity
ES968_12935	COG2264	protein methyltransferase activity
ES968_12940	COG0484	heat shock protein binding
ES968_12945	COG0443	Heat shock 70 kDa protein
ES968_12950	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
ES968_12955	COG1420	regulation of RNA biosynthetic process
ES968_12960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
ES968_12965	COG0481	GTPase activity
ES968_12975	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES968_12980	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
ES968_12985	COG0268	Binds directly to 16S ribosomal RNA
ES968_12990	COG1466	dna polymerase III delta subunit
ES968_13005	COG0658	competence protein
ES968_13005	COG2333	competence protein COMEC
ES968_13010	COG2131	deaminase
ES968_13015	COG1555	photosystem II stabilization
ES968_13015	COG1596	polysaccharide export
ES968_13020	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
ES968_13025	COG2226	methyltransferase
ES968_13030	COG0799	negative regulation of ribosome biogenesis
ES968_13035	COG1713	HD superfamily hydrolase involved in NAD metabolism
ES968_13040	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
ES968_13045	COG1534	Rna-binding protein
ES968_13050	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
ES968_13055	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
ES968_13060	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
ES968_13070	COG2755	lipolytic protein G-D-S-L family
ES968_13075	COG3409	Peptidoglycan-binding domain 1 protein
ES968_13075	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES968_13080	COG0398	Pfam SNARE associated Golgi protein
ES968_13085	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
ES968_13095	COG3209	COG3209 Rhs family protein
ES968_13115	COG0114	fumarate hydratase activity
ES968_13120	COG0583	DNA-binding transcription factor activity
ES968_13135	COG0457	Tetratricopeptide repeat
ES968_13270	COG4978	Transcriptional regulator
ES968_13270	COG0789	Transcriptional regulator
ES968_13275	COG2814	Major facilitator Superfamily
ES968_13280	COG0456	acetyltransferase
ES968_13285	COG3328	transposase activity
ES968_13295	COG1253	flavin adenine dinucleotide binding
ES968_13305	COG0697	spore germination
ES968_13310	COG0583	DNA-binding transcription factor activity
ES968_13315	COG2072	flavoprotein involved in K transport
ES968_13320	COG1230	cation diffusion facilitator family transporter
ES968_13330	COG1114	Component of the transport system for branched-chain amino acids
ES968_13335	COG1687	branched-chain amino acid
ES968_13340	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
ES968_13345	COG1522	sequence-specific DNA binding
ES968_13350	COG2732	(Barnase) inhibitor
ES968_13360	COG1335	isochorismatase
ES968_13375	COG2318	DinB family
ES968_13385	COG2070	2-Nitropropane dioxygenase
ES968_13400	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ES968_13420	COG3443	Belongs to the bacterial solute-binding protein 9 family
ES968_13425	COG1595	DNA-templated transcription, initiation
ES968_13435	COG3409	Peptidoglycan-binding domain 1 protein
ES968_13440	COG5566	PFAM Mor transcription activator
ES968_13445	COG0596	Alpha beta hydrolase
ES968_13450	COG4991	sh3 domain protein
ES968_13455	COG4991	sh3 domain protein
ES968_13465	COG0346	lactoylglutathione lyase activity
ES968_13475	COG5577	PFAM Coat F domain
ES968_13480	COG1063	alcohol dehydrogenase
ES968_13490	COG5577	PFAM Coat F domain
ES968_13495	COG0789	Transcriptional regulator
ES968_13505	COG1064	alcohol dehydrogenase
ES968_13510	COG0693	protein deglycase activity
ES968_13515	COG1621	beta-fructofuranosidase activity
ES968_13520	COG3716	PTS system mannose fructose sorbose family IID component
ES968_13525	COG3715	PTS system
ES968_13530	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES968_13535	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES968_13540	COG3933	PFAM sigma-54 factor interaction domain-containing protein
ES968_13540	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
ES968_13550	COG1113	amino acid transport
ES968_13555	COG1280	lysine exporter protein (LysE YggA)
ES968_13560	COG1378	Sugar-specific transcriptional regulator TrmB
ES968_13575	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
ES968_13575	COG2755	lipolytic protein G-D-S-L family
ES968_13585	COG2124	cytochrome p450
ES968_13585	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ES968_13590	COG1309	transcriptional regulator
ES968_13595	COG2226	methyltransferase
ES968_13610	COG2116	formate transmembrane transporter activity
ES968_13615	COG5609	conserved protein (DUF2294)
ES968_13620	COG3383	formate dehydrogenase (NAD+) activity
ES968_13625	COG2427	Protein of unknown function (DUF1641)
ES968_13635	COG0626	cystathionine gamma-synthase activity
ES968_13640	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES968_13645	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
ES968_13650	COG2226	methyltransferase
ES968_13665	COG0768	penicillin binding
ES968_13670	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
ES968_13675	COG0572	uridine kinase
ES968_13695	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
ES968_13700	COG3906	Belongs to the UPF0473 family
ES968_13705	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
ES968_13710	COG4472	Bacterial protein of unknown function (DUF965)
ES968_13715	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
ES968_13720	COG0628	permease
ES968_13725	COG1126	abc transporter atp-binding protein
ES968_13730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES968_13735	COG0765	amino acid transport
ES968_13740	COG0765	amino acid transport
ES968_13755	COG3881	PFAM PRC-barrel domain
ES968_13760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
ES968_13765	COG0457	Tetratricopeptide repeat
ES968_13770	COG0482	sulfurtransferase activity
ES968_13775	COG1104	cysteine desulfurase activity
ES968_13780	COG1959	2 iron, 2 sulfur cluster binding
ES968_13785	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
ES968_13790	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
ES968_13800	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
ES968_13805	COG0124	histidyl-tRNA synthetase
ES968_13815	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES968_13815	COG4991	sh3 domain protein
ES968_13815	COG3103	Sh3 type 3 domain protein
ES968_13820	COG1490	D-aminoacyl-tRNA deacylase activity
ES968_13825	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
ES968_13830	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
ES968_13835	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
ES968_13835	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
ES968_13840	COG5416	Lipopolysaccharide assembly protein A domain
ES968_13845	COG0490	domain, Protein
ES968_13850	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ES968_13850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
ES968_13860	COG2244	polysaccharide biosynthetic process
ES968_13865	COG2323	membrane
ES968_13875	COG1862	Preprotein translocase
ES968_13880	COG0343	queuine tRNA-ribosyltransferase activity
ES968_13885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
ES968_13895	COG2255	four-way junction helicase activity
ES968_13900	COG0632	four-way junction helicase activity
ES968_13910	COG2814	Major facilitator Superfamily
ES968_13915	COG0673	inositol 2-dehydrogenase activity
ES968_13920	COG2112	serine threonine protein kinase
ES968_13940	COG1115	amino acid carrier protein
ES968_13945	COG0217	transcriptional regulatory protein
ES968_13955	COG1388	LysM domain
ES968_13960	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
ES968_13965	COG0157	Belongs to the NadC ModD family
ES968_13970	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
ES968_13975	COG1104	cysteine desulfurase activity
ES968_13980	COG1827	regulation of RNA biosynthetic process
ES968_13985	COG0077	Prephenate dehydratase
ES968_13990	COG4492	Belongs to the UPF0735 family
ES968_13995	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
ES968_14000	COG3290	protein histidine kinase activity
ES968_14010	COG0211	Belongs to the bacterial ribosomal protein bL27 family
ES968_14015	COG2868	ribosomal protein
ES968_14020	COG0261	This protein binds to 23S rRNA in the presence of protein L20
ES968_14025	COG1994	Peptidase M50
ES968_14030	COG0739	heme binding
ES968_14035	COG2894	cell division
ES968_14040	COG0850	regulation of cytokinetic process
ES968_14045	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
ES968_14050	COG1792	Involved in formation and maintenance of cell shape
ES968_14055	COG1077	Cell shape determining protein MreB Mrl
ES968_14060	COG2003	Belongs to the UPF0758 family
ES968_14065	COG0424	maF-like protein
ES968_14075	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
ES968_14080	COG0285	dihydrofolate synthase activity
ES968_14085	COG0525	valine-tRNA ligase activity
ES968_14095	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES968_14100	COG1388	LysM domain
ES968_14105	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
ES968_14110	COG0113	porphobilinogen synthase activity
ES968_14115	COG1587	Uroporphyrinogen-III synthase
ES968_14120	COG0181	hydroxymethylbilane synthase activity
ES968_14125	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
ES968_14130	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
ES968_14140	COG0218	Necessary for normal cell division and for the maintenance of normal septation
ES968_14145	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
ES968_14150	COG0470	DNA polymerase III
ES968_14150	COG1067	ATP-dependent peptidase activity
ES968_14155	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
ES968_14160	COG0544	peptidyl-prolyl cis-trans isomerase activity
ES968_14165	COG1477	protein flavinylation
ES968_14165	COG0457	Tetratricopeptide repeat
ES968_14170	COG0066	3-isopropylmalate dehydratase activity
ES968_14175	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
ES968_14180	COG0473	3-isopropylmalate dehydrogenase activity
ES968_14185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
ES968_14190	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
ES968_14195	COG0440	acetolactate synthase activity
ES968_14200	COG0028	Belongs to the TPP enzyme family
ES968_14215	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
ES968_14240	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
ES968_14265	COG0622	Phosphoesterase
ES968_14270	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
ES968_14275	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
ES968_14280	COG5401	PFAM Sporulation and spore germination
ES968_14285	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
ES968_14290	COG1846	Transcriptional regulator
ES968_14295	COG2197	response regulator
ES968_14300	COG0824	Thioesterase
ES968_14305	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
ES968_14310	COG1053	succinate dehydrogenase
ES968_14315	COG2009	succinate dehydrogenase
ES968_14320	COG1719	4-vinyl reductase, 4VR
ES968_14325	COG0527	aspartate kinase activity
ES968_14335	COG0322	excinuclease ABC activity
ES968_14340	COG3118	belongs to the thioredoxin family
ES968_14350	COG3534	alpha-L-arabinofuranosidase
ES968_14355	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
ES968_14360	COG2086	electron transfer activity
ES968_14365	COG1024	Enoyl-CoA hydratase
ES968_14370	COG1309	transcriptional regulator
ES968_14375	COG0318	PFAM AMP-dependent synthetase and ligase
ES968_14380	COG3766	membrane
ES968_14385	COG1193	negative regulation of DNA recombination
ES968_14390	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ES968_14390	COG1796	DNA polymerase
ES968_14395	COG1286	toxin biosynthetic process
ES968_14400	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
ES968_14405	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
ES968_14410	COG0072	phenylalanine-tRNA ligase activity
ES968_14410	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES968_14415	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
ES968_14425	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
ES968_14435	COG3835	regulator
ES968_14440	COG0277	FAD linked oxidase domain protein
ES968_14445	COG0247	lactate metabolic process
ES968_14450	COG0346	lactoylglutathione lyase activity
ES968_14460	COG1966	Carbon starvation protein
ES968_14465	COG3534	alpha-L-arabinofuranosidase
ES968_14470	COG0395	ABC-type sugar transport system, permease component
ES968_14475	COG1175	transmembrane transport
ES968_14480	COG1653	transport
ES968_14485	COG0371	Dehydrogenase
ES968_14490	COG0647	UMP catabolic process
ES968_14495	COG0235	Class ii aldolase
ES968_14500	COG1069	ribulokinase activity
ES968_14505	COG2160	L-arabinose isomerase activity
ES968_14515	COG1363	Peptidase, m42
ES968_14525	COG3326	Membrane
ES968_14530	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
ES968_14535	COG0291	Belongs to the bacterial ribosomal protein bL35 family
ES968_14540	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
ES968_14550	COG1346	cytolysis
ES968_14555	COG1380	Effector of murein hydrolase LrgA
ES968_14560	COG3279	Response regulator of the LytR AlgR family
ES968_14565	COG3275	phosphorelay sensor kinase activity
ES968_14575	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ES968_14585	COG0398	Pfam SNARE associated Golgi protein
ES968_14590	COG1484	DNA-dependent DNA replication
ES968_14595	COG3611	Membrane attachment protein
ES968_14600	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
ES968_14605	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
ES968_14610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ES968_14615	COG1733	regulation of RNA biosynthetic process
ES968_14620	COG2814	Major facilitator Superfamily
ES968_14625	COG0656	L-ascorbic acid biosynthetic process
ES968_14630	COG0237	dephospho-CoA kinase activity
ES968_14635	COG1971	Probably functions as a manganese efflux pump
ES968_14640	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
ES968_14645	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES968_14645	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
ES968_14650	COG5002	protein histidine kinase activity
ES968_14655	COG0745	RESPONSE REGULATOR receiver
ES968_14660	COG0039	L-malate dehydrogenase activity
ES968_14665	COG0538	isocitrate dehydrogenase activity
ES968_14670	COG0372	Belongs to the citrate synthase family
ES968_14675	COG2707	UPF0756 membrane protein
ES968_14680	COG0628	permease
ES968_14685	COG3030	protein affecting phage T7 exclusion by the F plasmid
ES968_14690	COG0469	pyruvate kinase activity
ES968_14695	COG0205	6-phosphofructokinase activity
ES968_14700	COG0825	malonyl-CoA metabolic process
ES968_14705	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
ES968_14710	COG0281	malic enzyme
ES968_14715	COG0587	DNA-directed DNA polymerase activity
ES968_14735	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
ES968_14745	COG4109	DRTGG domain
ES968_14750	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
ES968_14755	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_14765	COG0165	Argininosuccinate lyase
ES968_14770	COG0137	argininosuccinate synthase activity
ES968_14775	COG0521	Mo-molybdopterin cofactor biosynthetic process
ES968_14780	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
ES968_14790	COG0827	DNA restriction-modification system
ES968_14795	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
ES968_14800	COG3874	Sporulation protein YtfJ
ES968_14810	COG1714	RDD family
ES968_14815	COG0616	signal peptide processing
ES968_14820	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
ES968_14825	COG1574	metal-dependent hydrolase with the TIM-barrel fold
ES968_14830	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ES968_14840	COG0301	tRNA thio-modification
ES968_14845	COG1104	cysteine desulfurase activity
ES968_14850	COG1114	Component of the transport system for branched-chain amino acids
ES968_14855	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
ES968_14860	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
ES968_14865	COG1309	transcriptional regulator
ES968_14870	COG1956	GAF domain-containing protein
ES968_14875	COG2199	diguanylate cyclase activity
ES968_14875	COG2203	Gaf domain
ES968_14885	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
ES968_14890	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ES968_14895	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
ES968_14900	COG0454	-acetyltransferase
ES968_14905	COG0517	IMP dehydrogenase activity
ES968_14910	COG0123	including yeast histone deacetylase and acetoin utilization protein
ES968_14915	COG1360	Flagellar Motor Protein
ES968_14920	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
ES968_14925	COG1609	Transcriptional regulator
ES968_14930	COG1605	Chorismate mutase
ES968_14930	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
ES968_14935	COG3118	belongs to the thioredoxin family
ES968_14940	COG4980	gas vesicle protein
ES968_14945	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
ES968_14950	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
ES968_14955	COG1674	ftsk spoiiie
ES968_14960	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
ES968_14965	COG4848	Belongs to the UPF0354 family
ES968_14970	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES968_14985	COG1363	Peptidase, m42
ES968_14990	COG5584	Small secreted protein
ES968_14995	COG0281	malic enzyme
ES968_15000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
ES968_15005	COG0220	tRNA (guanine-N7-)-methyltransferase activity
ES968_15015	COG0510	thiamine kinase activity
ES968_15020	COG1523	belongs to the glycosyl hydrolase 13 family
ES968_15025	COG1597	lipid kinase activity
ES968_15035	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
ES968_15040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
ES968_15045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES968_15050	COG2252	PERMEase
ES968_15055	COG4473	ABC transporter
ES968_15060	COG1131	(ABC) transporter
ES968_15065	COG1349	DNA-binding transcription factor activity
ES968_15070	COG1187	pseudouridine synthase activity
ES968_15075	COG2244	polysaccharide biosynthetic process
ES968_15080	COG2081	HI0933 family
ES968_15085	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
ES968_15105	COG1653	transport
ES968_15110	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
ES968_15115	COG4209	transmembrane transport
ES968_15125	COG1653	transport
ES968_15130	COG0395	ABC-type sugar transport system, permease component
ES968_15135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES968_15140	COG2124	cytochrome p450
ES968_15145	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
ES968_15160	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
ES968_15170	COG1073	alpha beta
ES968_15195	COG1486	melibiose metabolic process
ES968_15200	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
ES968_15205	COG0495	leucyl-tRNA aminoacylation
ES968_15215	COG1366	Belongs to the anti-sigma-factor antagonist family
ES968_15215	COG2202	Pas domain
ES968_15220	COG2814	Major facilitator Superfamily
ES968_15225	COG2433	Pfam Transposase IS66
ES968_15230	COG0577	efflux transmembrane transporter activity
ES968_15235	COG1136	(ABC) transporter
ES968_15240	COG2205	protein histidine kinase activity
ES968_15245	COG0745	RESPONSE REGULATOR receiver
ES968_15250	COG0577	efflux transmembrane transporter activity
ES968_15255	COG1136	(ABC) transporter
ES968_15270	COG1131	(ABC) transporter
ES968_15275	COG1725	Transcriptional regulator
ES968_15290	COG1242	4 iron, 4 sulfur cluster binding
ES968_15295	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
ES968_15305	COG2267	carboxylic ester hydrolase activity
ES968_15310	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
ES968_15315	COG1113	amino acid transport
ES968_15320	COG0367	asparagine synthase
ES968_15325	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
ES968_15330	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
ES968_15340	COG1506	peptidase
ES968_15345	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
ES968_15350	COG1116	anion transmembrane transporter activity
ES968_15355	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
ES968_15360	COG0494	nUDIX hydrolase
ES968_15365	COG4824	toxin secretion phage lysis holin
ES968_15370	COG0783	Belongs to the Dps family
ES968_15385	COG1854	S-ribosylhomocysteine lyase activity
ES968_15390	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
ES968_15395	COG0288	reversible hydration of carbon dioxide
ES968_15400	COG0254	rRNA binding
ES968_15405	COG1271	oxidase subunit
ES968_15410	COG1294	oxidase, subunit
ES968_15420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES968_15425	COG1108	ABC-type Mn2 Zn2 transport systems permease components
ES968_15425	COG1321	iron dependent repressor
ES968_15430	COG1121	(ABC) transporter
ES968_15435	COG0803	Belongs to the bacterial solute-binding protein 9 family
ES968_15440	COG4948	Mandelate Racemase Muconate Lactonizing
ES968_15445	COG0318	PFAM AMP-dependent synthetase and ligase
ES968_15450	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
ES968_15455	COG0596	Alpha beta hydrolase
ES968_15460	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
ES968_15465	COG1169	isochorismate synthase
ES968_15475	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
ES968_15480	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ES968_15485	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ES968_15490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
ES968_15495	COG0438	transferase activity, transferring glycosyl groups
ES968_15505	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES968_15510	COG0438	transferase activity, transferring glycosyl groups
ES968_15515	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES968_15520	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
ES968_15530	COG0058	SHG alpha-glucan phosphorylase activity
ES968_15535	COG0297	glycogen (starch) synthase activity
ES968_15540	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ES968_15545	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
ES968_15550	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
ES968_15675	COG3859	Proton-coupled thiamine transporter YuaJ
ES968_15680	COG1247	-acetyltransferase
ES968_15685	COG2268	Band 7 protein
ES968_15690	COG1585	Membrane protein implicated in regulation of membrane protease activity
ES968_15705	COG1454	alcohol dehydrogenase
ES968_15715	COG1510	regulation of RNA biosynthetic process
ES968_15725	COG0569	domain protein
ES968_15730	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
ES968_15735	COG4682	membrane
ES968_15740	COG1705	Flagellar rod assembly protein muramidase FlgJ
ES968_15745	COG0477	Major facilitator Superfamily
ES968_15750	COG5553	Cysteine dioxygenase type I
ES968_15760	COG1968	undecaprenyl-diphosphatase activity
ES968_15765	COG0628	permease
ES968_15770	COG0673	inositol 2-dehydrogenase activity
ES968_15780	COG3254	rhamnose metabolic process
ES968_15785	COG1070	Carbohydrate kinase
ES968_15790	COG1349	DNA-binding transcription factor activity
ES968_15795	COG3347	Dehydrogenase
ES968_15795	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_15805	COG0840	transmembrane signaling receptor activity
ES968_15810	COG0840	transmembrane signaling receptor activity
ES968_15820	COG0840	transmembrane signaling receptor activity
ES968_15835	COG0432	Pfam Uncharacterised protein family UPF0047
ES968_15845	COG0366	Alpha amylase catalytic
ES968_15850	COG1253	flavin adenine dinucleotide binding
ES968_15855	COG2738	Putative neutral zinc metallopeptidase
ES968_15870	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
ES968_15885	COG0166	Belongs to the GPI family
ES968_15890	COG1979	alcohol dehydrogenase
ES968_15895	COG1979	alcohol dehydrogenase
ES968_15900	COG2155	Conserved Protein
ES968_15905	COG1098	S1 RNA binding domain
ES968_15910	COG0436	Aminotransferase
ES968_15915	COG1522	sequence-specific DNA binding
ES968_15920	COG2267	carboxylic ester hydrolase activity
ES968_15930	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
ES968_15935	COG2205	protein histidine kinase activity
ES968_15945	COG5018	Exonuclease
ES968_15955	COG2814	Major facilitator Superfamily
ES968_15960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES968_15965	COG3011	Protein conserved in bacteria
ES968_15975	COG3290	protein histidine kinase activity
ES968_15980	COG4565	transcriptional regulatory protein
ES968_16005	COG3493	citrate carrier protein
ES968_16015	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
ES968_16015	COG2111	Na H antiporter
ES968_16020	COG2111	Na H antiporter
ES968_16025	COG1006	Multisubunit Na H antiporter MnhC subunit
ES968_16030	COG0651	ATP synthesis coupled electron transport
ES968_16035	COG1863	multisubunit Na H antiporter MnhE subunit
ES968_16040	COG2212	antiporter activity
ES968_16045	COG1320	monovalent cation:proton antiporter activity
ES968_16050	COG2050	protein possibly involved in aromatic compounds catabolism
ES968_16055	COG2197	response regulator
ES968_16060	COG4585	Histidine kinase
ES968_16070	COG0142	geranyltranstransferase activity
ES968_16090	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
ES968_16095	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
ES968_16100	COG1335	isochorismatase
ES968_16105	COG5506	Protein of unknown function (DUF1694)
ES968_16120	COG0628	permease
ES968_16135	COG1418	mRNA catabolic process
ES968_16140	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_16150	COG1511	domain protein
ES968_16155	COG0433	COG0433 Predicted ATPase
ES968_16155	COG1674	ftsk spoiiie
ES968_16160	COG4499	WXG100 protein secretion system (Wss), protein YukC
ES968_16165	COG5417	Belongs to the EsaB family
ES968_16170	COG4842	Belongs to the WXG100 family
ES968_16180	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
ES968_16180	COG2508	Transcriptional regulator
ES968_16185	COG0686	Belongs to the AlaDH PNT family
ES968_16190	COG5634	Uncharacterized conserved protein (DUF2278)
ES968_16195	COG3251	PFAM MbtH domain protein
ES968_16200	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES968_16205	COG3433	isochorismatase activity
ES968_16205	COG1535	isochorismatase
ES968_16210	COG1021	2,3-dihydroxybenzoate-AMP ligase
ES968_16215	COG1169	isochorismate synthase
ES968_16220	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_16225	COG2819	hydrolase of the alpha beta superfamily
ES968_16230	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
ES968_16235	COG1268	BioY protein
ES968_16240	COG2056	Na+-H+ antiporter family
ES968_16245	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
ES968_16250	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
ES968_16255	COG3584	3D domain protein
ES968_16270	COG1252	NADH dehydrogenase
ES968_16275	COG0492	ferredoxin-NADP+ reductase activity
ES968_16285	COG0516	GMP reductase activity
ES968_16290	COG2808	Putative FMN-binding domain
ES968_16295	COG0456	acetyltransferase
ES968_16395	COG0582	viral genome integration into host DNA
ES968_16405	COG4974	Belongs to the 'phage' integrase family
ES968_16410	COG0316	Belongs to the HesB IscA family
ES968_16415	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
ES968_16420	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES968_16425	COG4844	belongs to the
ES968_16430	COG1252	NADH dehydrogenase
ES968_16435	COG4837	Protein of unknown function (DUF1462)
ES968_16440	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
ES968_16445	COG1506	peptidase
ES968_16445	COG4946	Tricorn protease homolog
ES968_16445	COG0823	Involved in the tonB-independent uptake of proteins
ES968_16450	COG0083	homoserine kinase activity
ES968_16455	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
ES968_16460	COG0460	homoserine dehydrogenase
ES968_16465	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
ES968_16470	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
ES968_16475	COG0647	UMP catabolic process
ES968_16480	COG2445	Protein of unknown function DUF86
ES968_16485	COG4470	Protein conserved in bacteria
ES968_16495	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
ES968_16500	COG0739	heme binding
ES968_16510	COG3377	Domain of unknown function (DUF1805)
ES968_16515	COG0737	Belongs to the 5'-nucleotidase family
ES968_16520	COG0730	response to heat
ES968_16525	COG1801	Protein of unknown function DUF72
ES968_16535	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
ES968_16540	COG2508	Transcriptional regulator
ES968_16545	COG2233	PERMEase
ES968_16550	COG2233	PERMEase
ES968_16555	COG3648	Uricase
ES968_16555	COG3195	allantoin biosynthetic process
ES968_16560	COG2351	hydroxyisourate hydrolase activity
ES968_16570	COG2080	2 iron, 2 sulfur cluster binding
ES968_16575	COG1529	Aldehyde oxidase and xanthine dehydrogenase
ES968_16580	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
ES968_16585	COG2068	MobA-Related Protein
ES968_16590	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
ES968_16595	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
ES968_16600	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
ES968_16610	COG2356	endonuclease I
ES968_16615	COG3842	ATPase activity
ES968_16620	COG2188	Transcriptional regulator
ES968_16625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES968_16630	COG0395	ABC-type sugar transport system, permease component
ES968_16635	COG1175	transmembrane transport
ES968_16640	COG1653	transport
ES968_16645	COG2222	sugar isomerase
ES968_16650	COG0322	excinuclease ABC activity
ES968_16655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
ES968_16675	COG0346	lactoylglutathione lyase activity
ES968_16680	COG0640	Transcriptional regulator
ES968_16690	COG5444	nuclease activity
ES968_16700	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES968_16700	COG3409	Peptidoglycan-binding domain 1 protein
ES968_16705	COG4824	toxin secretion phage lysis holin
ES968_16740	COG3953	SLT domain
ES968_16740	COG5412	phage tail tape measure protein
ES968_16835	COG0582	viral genome integration into host DNA
ES968_16915	COG3800	Transcriptional regulator
ES968_16915	COG1396	sequence-specific DNA binding
ES968_16935	COG0719	Fe-S assembly protein
ES968_16940	COG0822	iron-sulfur transferase activity
ES968_16945	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
ES968_16950	COG0719	Fe-S assembly protein
ES968_16955	COG0396	ATPase activity
ES968_16970	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
ES968_16975	COG1464	Belongs to the NlpA lipoprotein family
ES968_16980	COG2011	ABC-type metal ion transport system permease component
ES968_16985	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
ES968_16995	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
ES968_17000	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
ES968_17010	COG0509	glycine decarboxylation via glycine cleavage system
ES968_17015	COG1393	Belongs to the ArsC family
ES968_17020	COG1960	acyl-CoA dehydrogenase activity
ES968_17025	COG0183	Belongs to the thiolase family
ES968_17030	COG1024	Enoyl-CoA hydratase
ES968_17030	COG1250	3-hydroxyacyl-CoA dehydrogenase
ES968_17040	COG0506	proline dehydrogenase activity
ES968_17050	COG5577	PFAM Coat F domain
ES968_17055	COG1846	Transcriptional regulator
ES968_17060	COG0477	Major facilitator Superfamily
ES968_17065	COG1942	4-Oxalocrotonate Tautomerase
ES968_17070	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_17075	COG0583	DNA-binding transcription factor activity
ES968_17085	COG1120	ATPase activity
ES968_17120	COG1131	(ABC) transporter
ES968_17165	COG0783	Belongs to the Dps family
ES968_17170	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES968_17175	COG0745	RESPONSE REGULATOR receiver
ES968_17180	COG2770	Histidine kinase
ES968_17180	COG2205	protein histidine kinase activity
ES968_17190	COG1309	transcriptional regulator
ES968_17195	COG0114	fumarate hydratase activity
ES968_17205	COG0697	spore germination
ES968_17210	COG0814	amino acid
ES968_17220	COG2197	response regulator
ES968_17225	COG4585	Histidine kinase
ES968_17230	COG4758	membrane
ES968_17235	COG3595	metallopeptidase activity
ES968_17240	COG1842	Phage shock protein A
ES968_17245	COG4758	membrane
ES968_17250	COG2814	Major facilitator Superfamily
ES968_17255	COG2096	Adenosyltransferase
ES968_17260	COG1120	ATPase activity
ES968_17265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES968_17270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES968_17280	COG3386	PFAM SMP-30 Gluconolaconase
ES968_17285	COG2205	protein histidine kinase activity
ES968_17290	COG0745	RESPONSE REGULATOR receiver
ES968_17300	COG1191	sigma factor activity
ES968_17310	COG2140	Oxalate decarboxylase
ES968_17320	COG0577	efflux transmembrane transporter activity
ES968_17325	COG1136	(ABC) transporter
ES968_17330	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
ES968_17335	COG1120	ATPase activity
ES968_17340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES968_17345	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
ES968_17350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES968_17360	COG0531	amino acid
ES968_17375	COG1988	membrane-bound metal-dependent
ES968_17380	COG1368	sulfuric ester hydrolase activity
ES968_17385	COG1910	domain protein
ES968_17390	COG0725	ABC transporter, periplasmic molybdate-binding protein
ES968_17395	COG4149	molybdate abc transporter
ES968_17400	COG0656	L-ascorbic acid biosynthetic process
ES968_17410	COG0025	NhaP-type Na H and K H
ES968_17415	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
ES968_17420	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
ES968_17425	COG3973	AAA domain
ES968_17435	COG2860	membrane
ES968_17440	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
ES968_17445	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
ES968_17450	COG2217	Heavy metal translocating P-type atpase
ES968_17455	COG2217	Heavy metal translocating P-type atpase
ES968_17460	COG2608	mercury ion transmembrane transporter activity
ES968_17465	COG1937	Protein conserved in bacteria
ES968_17470	COG0673	inositol 2-dehydrogenase activity
ES968_17475	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
ES968_17480	COG1289	transmembrane transporter activity
ES968_17490	COG2076	Multidrug Resistance protein
ES968_17495	COG1309	transcriptional regulator
ES968_17500	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_17510	COG5444	nuclease activity
ES968_17525	COG3409	Peptidoglycan-binding domain 1 protein
ES968_17525	COG5632	N-Acetylmuramoyl-L-alanine amidase
ES968_17530	COG4824	toxin secretion phage lysis holin
ES968_17555	COG1705	Flagellar rod assembly protein muramidase FlgJ
ES968_17555	COG3942	CHAP domain
ES968_17780	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
ES968_17785	COG0557	exoribonuclease II activity
ES968_17790	COG1647	Serine aminopeptidase, S33
ES968_17795	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
ES968_17800	COG0596	Alpha beta hydrolase
ES968_17805	COG1476	TRANSCRIPTIONal
ES968_17810	COG1396	sequence-specific DNA binding
ES968_17815	COG1396	sequence-specific DNA binding
ES968_17820	COG1733	regulation of RNA biosynthetic process
ES968_17825	COG0840	transmembrane signaling receptor activity
ES968_17830	COG1174	glycine betaine transport
ES968_17835	COG1732	Glycine betaine
ES968_17840	COG1174	glycine betaine transport
ES968_17845	COG0517	IMP dehydrogenase activity
ES968_17845	COG1125	glycine betaine transport
ES968_17850	COG1510	regulation of RNA biosynthetic process
ES968_17855	COG1174	glycine betaine transport
ES968_17860	COG1732	Glycine betaine
ES968_17865	COG1174	glycine betaine transport
ES968_17870	COG0517	IMP dehydrogenase activity
ES968_17870	COG1125	glycine betaine transport
ES968_17875	COG1510	regulation of RNA biosynthetic process
ES968_17880	COG2095	MarC family integral membrane protein
ES968_17890	COG3064	Membrane
ES968_17895	COG4640	response to antibiotic
ES968_17900	COG0456	acetyltransferase
ES968_17905	COG0148	phosphopyruvate hydratase activity
ES968_17910	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
ES968_17915	COG0149	triose-phosphate isomerase activity
ES968_17920	COG0126	phosphoglycerate kinase activity
ES968_17925	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
ES968_17930	COG2390	Transcriptional regulator
ES968_17935	COG2814	Major facilitator Superfamily
ES968_17940	COG1609	Transcriptional regulator
ES968_17945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES968_17955	COG0583	DNA-binding transcription factor activity
ES968_17960	COG0697	spore germination
ES968_17965	COG1113	amino acid transport
ES968_17975	COG1556	Lactate utilization protein
ES968_17980	COG1139	Iron-sulfur cluster binding protein
ES968_17985	COG0247	lactate metabolic process
ES968_18000	COG2197	response regulator
ES968_18005	COG4585	Histidine kinase
ES968_18010	COG0842	Transport permease protein
ES968_18015	COG1131	(ABC) transporter
ES968_18020	COG0596	Alpha beta hydrolase
ES968_18025	COG2208	phosphoserine phosphatase activity
ES968_18030	COG3867	Arabinogalactan endo-beta-1,4-galactanase
ES968_18035	COG1874	Beta-galactosidase
ES968_18040	COG3833	ABC-type maltose transport systems, permease component
ES968_18045	COG1175	transmembrane transport
ES968_18050	COG2182	Extracellular solute-binding protein
ES968_18055	COG1609	Transcriptional regulator
ES968_18060	COG2186	Transcriptional regulator
ES968_18065	COG1620	l-lactate permease
ES968_18070	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
ES968_18080	COG5039	Polysaccharide pyruvyl transferase
ES968_18085	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES968_18090	COG0110	maltose O-acetyltransferase activity
ES968_18095	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
ES968_18100	COG2244	polysaccharide biosynthetic process
ES968_18105	COG1216	Glycosyl transferase, family 2
ES968_18110	COG5039	Polysaccharide pyruvyl transferase
ES968_18115	COG1216	Glycosyl transferase, family 2
ES968_18125	COG0438	transferase activity, transferring glycosyl groups
ES968_18130	COG1215	transferase activity, transferring glycosyl groups
ES968_18135	COG0438	transferase activity, transferring glycosyl groups
ES968_18140	COG1086	Polysaccharide biosynthesis protein
ES968_18145	COG0489	protein tyrosine kinase activity
ES968_18150	COG3944	biosynthesis protein
ES968_18155	COG1396	sequence-specific DNA binding
ES968_18160	COG2272	Belongs to the type-B carboxylesterase lipase family
ES968_18170	COG3479	Phenolic acid decarboxylase
ES968_18185	COG1794	racemase activity, acting on amino acids and derivatives
ES968_18195	COG1621	beta-fructofuranosidase activity
ES968_18200	COG1621	beta-fructofuranosidase activity
ES968_18205	COG0531	amino acid
ES968_18210	COG1309	transcriptional regulator
ES968_18215	COG2076	Multidrug Resistance protein
ES968_18220	COG2076	Multidrug Resistance protein
ES968_18235	COG0740	serine-type endopeptidase activity
ES968_18240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
ES968_18245	COG0366	Alpha amylase catalytic
ES968_18250	COG1554	hydrolase, family 65, central catalytic
ES968_18260	COG3833	ABC-type maltose transport systems, permease component
ES968_18265	COG1175	transmembrane transport
ES968_18275	COG0366	Alpha amylase catalytic
ES968_18280	COG1609	Transcriptional regulator
ES968_18285	COG1611	Belongs to the LOG family
ES968_18295	COG0659	secondary active sulfate transmembrane transporter activity
ES968_18300	COG0288	reversible hydration of carbon dioxide
ES968_18305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
ES968_18310	COG0577	efflux transmembrane transporter activity
ES968_18315	COG1136	(ABC) transporter
ES968_18320	COG5002	protein histidine kinase activity
ES968_18325	COG0745	RESPONSE REGULATOR receiver
ES968_18335	COG2162	N-hydroxyarylamine O-acetyltransferase activity
ES968_18340	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES968_18345	COG1481	regulation of sporulation
ES968_18350	COG0391	Required for morphogenesis under gluconeogenic growth conditions
ES968_18355	COG1660	Displays ATPase and GTPase activities
ES968_18360	COG1051	belongs to the nudix hydrolase family
ES968_18365	COG0492	ferredoxin-NADP+ reductase activity
ES968_18370	COG3883	PFAM NLP P60 protein
ES968_18370	COG0791	NLP P60 protein
ES968_18375	COG0457	Tetratricopeptide repeat
ES968_18380	COG1132	(ABC) transporter
ES968_18400	COG0140	phosphoribosyl-ATP diphosphatase activity
ES968_18400	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
ES968_18405	COG0107	imidazoleglycerol-phosphate synthase activity
ES968_18410	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
ES968_18415	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
ES968_18420	COG0131	Imidazoleglycerol-phosphate dehydratase
ES968_18425	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
ES968_18430	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
ES968_18435	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
ES968_18440	COG4990	cell redox homeostasis
ES968_18445	COG5297	Belongs to the glycosyl hydrolase family 6
ES968_18450	COG0110	maltose O-acetyltransferase activity
ES968_18455	COG0546	phosphoglycolate phosphatase activity
ES968_18460	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
ES968_18465	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
ES968_18470	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
ES968_18475	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
ES968_18480	COG0363	glucosamine-6-phosphate deaminase activity
ES968_18490	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
ES968_18495	COG1950	PFAM Membrane protein of
ES968_18500	COG1983	PspC domain protein
ES968_18505	COG3595	metallopeptidase activity
ES968_18520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ES968_18525	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
ES968_18530	COG0556	nucleotide-excision repair
ES968_18535	COG4897	Protein conserved in bacteria
ES968_18540	COG3848	Pyruvate phosphate dikinase
ES968_18540	COG0574	Belongs to the PEP-utilizing enzyme family
ES968_18545	COG1309	transcriptional regulator
ES968_18550	COG2814	Major facilitator Superfamily
ES968_18555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES968_18565	COG3409	Peptidoglycan-binding domain 1 protein
ES968_18565	COG0793	Belongs to the peptidase S41A family
ES968_18570	COG2177	Part of the ABC transporter FtsEX involved in
ES968_18575	COG2884	Cell division ATP-binding protein ftsE
ES968_18580	COG2010	Cytochrome c
ES968_18585	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES968_18595	COG0653	protein targeting
ES968_18600	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
ES968_18615	COG1516	flagellar protein fliS
ES968_18620	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
ES968_18625	COG1334	flagellar protein FlaG
ES968_18630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ES968_18635	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
ES968_18640	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
ES968_18650	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
ES968_18655	COG1256	bacterial-type flagellum assembly
ES968_18655	COG4786	Flagellar basal body rod
ES968_18660	COG3418	PFAM FlgN family protein
ES968_18665	COG2747	anti-sigma28 factor FlgM
ES968_18675	COG1040	competence protein
ES968_18685	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
ES968_18690	COG1307	EDD domain protein, DegV family
ES968_18695	COG2197	response regulator
ES968_18700	COG4585	Histidine kinase
ES968_18705	COG1739	Uncharacterized protein family UPF0029
ES968_18710	COG1316	TRANSCRIPTIONal
ES968_18745	COG1131	(ABC) transporter
ES968_18755	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
ES968_18760	COG0438	transferase activity, transferring glycosyl groups
ES968_18765	COG1215	transferase activity, transferring glycosyl groups
ES968_18770	COG3206	protein involved in exopolysaccharide biosynthesis
ES968_18775	COG3307	-O-antigen
ES968_18785	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ES968_18790	COG0438	transferase activity, transferring glycosyl groups
ES968_18790	COG0297	glycogen (starch) synthase activity
ES968_18795	COG2244	polysaccharide biosynthetic process
ES968_18805	COG0860	N-Acetylmuramoyl-L-alanine amidase
ES968_18805	COG2247	cell wall binding repeat
ES968_18810	COG2385	sporulation resulting in formation of a cellular spore
ES968_18810	COG2247	cell wall binding repeat
ES968_18825	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
ES968_18830	COG1210	Utp--glucose-1-phosphate uridylyltransferase
ES968_18840	COG1134	teichoic acid transport
ES968_18845	COG1682	transport, permease protein
ES968_18860	COG0463	Glycosyl transferase, family 2
ES968_18860	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES968_18865	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES968_18870	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ES968_18875	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
ES968_18880	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES968_18885	COG4193	domain, Protein
ES968_18890	COG1482	cell wall glycoprotein biosynthetic process
ES968_18895	COG0697	spore germination
ES968_18900	COG0814	amino acid
ES968_18915	COG1316	TRANSCRIPTIONal
ES968_18920	COG0561	phosphatase activity
ES968_18925	COG0791	NLP P60 protein
ES968_18935	COG2843	Capsule synthesis protein
ES968_18945	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
ES968_18950	COG1609	Transcriptional regulator
ES968_18955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES968_18960	COG1869	D-ribose catabolic process
ES968_18965	COG1129	ABC transporter
ES968_18970	COG1172	Belongs to the binding-protein-dependent transport system permease family
ES968_18975	COG1879	ABC-type sugar transport system periplasmic component
ES968_18980	COG3103	Sh3 type 3 domain protein
ES968_18990	COG2249	NAD(P)H dehydrogenase (quinone) activity
ES968_18995	COG3527	Alpha-acetolactate decarboxylase
ES968_19000	COG0028	Belongs to the TPP enzyme family
ES968_19005	COG0583	DNA-binding transcription factor activity
ES968_19010	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
ES968_19025	COG5337	Spore coat protein CotH
ES968_19035	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
ES968_19045	COG0405	Gamma-glutamyltransferase
ES968_19050	COG1522	sequence-specific DNA binding
ES968_19055	COG2059	Chromate
ES968_19060	COG2059	Chromate
ES968_19070	COG0655	NAD(P)H dehydrogenase (quinone) activity
ES968_19075	COG0583	DNA-binding transcription factor activity
ES968_19105	COG5444	nuclease activity
ES968_19125	COG3878	Protein conserved in bacteria
ES968_19130	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
ES968_19135	COG4464	protein tyrosine phosphatase activity
ES968_19140	COG0489	protein tyrosine kinase activity
ES968_19145	COG3944	biosynthesis protein
ES968_19155	COG4715	Zinc finger, swim domain protein
ES968_19160	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
ES968_19170	COG0561	phosphatase activity
ES968_19175	COG1349	DNA-binding transcription factor activity
ES968_19180	COG0629	single-stranded DNA binding
ES968_19195	COG3764	Sortase (surface protein transpeptidase)
ES968_19205	COG2972	Histidine kinase
ES968_19205	COG0745	RESPONSE REGULATOR receiver
ES968_19210	COG1970	mechanosensitive ion channel activity
ES968_19215	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
ES968_19220	COG0457	Tetratricopeptide repeat
ES968_19225	COG4786	Flagellar basal body rod
ES968_19230	COG4786	Flagellar basal body rod
ES968_19235	COG1077	Cell shape determining protein MreB Mrl
ES968_19240	COG1609	Transcriptional regulator
ES968_19250	COG1846	Transcriptional regulator
ES968_19255	COG2814	Major facilitator Superfamily
ES968_19265	COG1953	Uracil, thiamine, allantoin
ES968_19270	COG0477	Major facilitator Superfamily
ES968_19275	COG1335	isochorismatase
ES968_19285	COG0004	ammonium transporteR
ES968_19290	COG0347	Belongs to the P(II) protein family
ES968_19295	COG0671	phosphoesterase, PA-phosphatase related
ES968_19305	COG0739	heme binding
ES968_19310	COG1247	-acetyltransferase
ES968_19320	COG2089	acid synthase
ES968_19330	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES968_19335	COG0789	Transcriptional regulator
ES968_19350	COG1959	2 iron, 2 sulfur cluster binding
ES968_19355	COG0804	urea catabolic process
ES968_19360	COG0832	Belongs to the urease beta subunit family
ES968_19365	COG0831	urea catabolic process
ES968_19380	COG3237	CsbD-like
ES968_19385	COG1994	Peptidase M50
ES968_19390	COG0457	Tetratricopeptide repeat
ES968_19395	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
ES968_19400	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
ES968_19410	COG2304	oxidoreductase activity
ES968_19420	COG2304	oxidoreductase activity
ES968_19425	COG2385	sporulation resulting in formation of a cellular spore
ES968_19430	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ES968_19440	COG4836	Membrane
ES968_19450	COG0355	proton-transporting ATP synthase activity, rotational mechanism
ES968_19455	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
ES968_19460	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
ES968_19465	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
ES968_19470	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ES968_19475	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
ES968_19480	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
ES968_19485	COG0356	it plays a direct role in the translocation of protons across the membrane
ES968_19495	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
ES968_19500	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
ES968_19505	COG4475	Protein of unknown function (DUF436)
ES968_19510	COG0698	ribose 5-phosphate isomerase
ES968_19515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
ES968_19520	COG1971	Probably functions as a manganese efflux pump
ES968_19525	COG0009	L-threonylcarbamoyladenylate synthase
ES968_19530	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
ES968_19550	COG2890	protein-(glutamine-N5) methyltransferase activity
ES968_19555	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
ES968_19560	COG0346	lactoylglutathione lyase activity
ES968_19565	COG0789	Transcriptional regulator
ES968_19570	COG0679	Auxin Efflux Carrier
ES968_19575	COG0281	malic enzyme
ES968_19580	COG1435	thymidine kinase activity
ES968_19585	COG0254	rRNA binding
ES968_19590	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
ES968_19600	COG1494	fructose-1,6-bisphosphatase
ES968_19605	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
ES968_19610	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
ES968_19615	COG0191	fructose-bisphosphate aldolase activity
ES968_19620	COG2204	response regulator
ES968_19625	COG4821	SIS domain
ES968_19630	COG0504	CTP synthase activity
ES968_19635	COG3343	RNA polymerase activity
ES968_19640	COG1960	acyl-CoA dehydrogenase activity
ES968_19645	COG0247	lactate metabolic process
ES968_19645	COG2181	nitrate reductase activity
ES968_19650	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES968_19655	COG4294	response to UV
ES968_19665	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ES968_19670	COG1132	(ABC) transporter
ES968_19675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
ES968_19685	COG2181	nitrate reductase activity
ES968_19690	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
ES968_19695	COG1140	nitrate reductase beta subunit
ES968_19700	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
ES968_19710	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ES968_19720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
ES968_19725	COG2223	nitrite transmembrane transporter activity
ES968_19730	COG0018	arginyl-trna synthetase
ES968_19735	COG4506	Protein conserved in bacteria
ES968_19750	COG0535	radical SAM domain protein
ES968_19760	COG1131	(ABC) transporter
ES968_19765	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
ES968_19770	COG0612	Peptidase, M16
ES968_19775	COG0612	Peptidase, M16
ES968_19785	COG3391	amine dehydrogenase activity
ES968_19790	COG3391	amine dehydrogenase activity
ES968_19800	COG0457	Tetratricopeptide repeat
ES968_19815	COG0010	Belongs to the arginase family
ES968_19820	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
ES968_19825	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
ES968_19840	COG1994	Peptidase M50
ES968_19845	COG1942	4-Oxalocrotonate Tautomerase
ES968_19850	COG1846	Transcriptional regulator
ES968_19855	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
ES968_19865	COG0477	Major facilitator Superfamily
ES968_19870	COG1959	2 iron, 2 sulfur cluster binding
ES968_19875	COG3465	dGTPase activity
ES968_19880	COG1078	dGTPase activity
ES968_19885	COG4844	belongs to the
ES968_19895	COG0697	spore germination
ES968_19900	COG0095	Lipoate-protein ligase
ES968_19905	COG0583	DNA-binding transcription factor activity
ES968_19910	COG0280	phosphate acetyltransferase
ES968_19925	COG0436	Aminotransferase
ES968_19930	COG2814	Major facilitator Superfamily
ES968_19935	COG0151	Belongs to the GarS family
ES968_19940	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_19950	COG0077	Prephenate dehydratase
ES968_19955	COG2814	Major facilitator Superfamily
ES968_19960	COG0833	amino acid
ES968_19965	COG4187	Peptidase family M20/M25/M40
ES968_19970	COG1012	belongs to the aldehyde dehydrogenase family
ES968_19975	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
ES968_19985	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
ES968_19990	COG1091	dTDP-4-dehydrorhamnose reductase activity
ES968_19995	COG1088	dTDP-glucose 4,6-dehydratase activity
ES968_20000	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
ES968_20005	COG3980	spore coat polysaccharide biosynthesis protein
ES968_20010	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
ES968_20015	COG2089	acid synthase
ES968_20020	COG0456	acetyltransferase
ES968_20025	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
ES968_20030	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
ES968_20035	COG0463	Glycosyl transferase, family 2
ES968_20045	COG2363	Small membrane protein
ES968_20050	COG2233	PERMEase
ES968_20060	COG1012	belongs to the aldehyde dehydrogenase family
ES968_20065	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
ES968_20070	COG1216	Glycosyl transferase, family 2
ES968_20085	COG1695	Transcriptional regulator
ES968_20090	COG0351	phosphomethylpyrimidine kinase
ES968_20100	COG1621	beta-fructofuranosidase activity
ES968_20105	COG1263	PTS System
ES968_20105	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES968_20110	COG2116	formate transmembrane transporter activity
ES968_20115	COG3711	transcriptional antiterminator
ES968_20125	COG1404	Belongs to the peptidase S8 family
ES968_20130	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
ES968_20135	COG0778	Nitroreductase
ES968_20145	COG0772	Belongs to the SEDS family
ES968_20160	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
ES968_20165	COG1845	cytochrome c oxidase, subunit III
ES968_20170	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
ES968_20175	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
ES968_20180	COG2261	transglycosylase associated protein
ES968_20185	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
ES968_20190	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
ES968_20195	COG2246	polysaccharide biosynthetic process
ES968_20200	COG1309	transcriptional regulator
ES968_20210	COG3162	membrane
ES968_20215	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
ES968_20220	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
ES968_20225	COG2837	iron assimilation
ES968_20230	COG2822	iron ion transport
ES968_20235	COG0672	)-iron permease
ES968_20240	COG0352	thiamine-phosphate diphosphorylase activity
ES968_20245	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
ES968_20250	COG0583	DNA-binding transcription factor activity
ES968_20255	COG1380	Effector of murein hydrolase LrgA
ES968_20260	COG1346	cytolysis
ES968_20265	COG2814	Major facilitator Superfamily
ES968_20270	COG4895	conserved protein (DUF2196)
ES968_20275	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
ES968_20280	COG0346	lactoylglutathione lyase activity
ES968_20290	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES968_20295	COG1404	Belongs to the peptidase S8 family
ES968_20300	COG1263	PTS System
ES968_20300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
ES968_20305	COG3711	transcriptional antiterminator
ES968_20310	COG1442	glycosyl transferase family 8
ES968_20315	COG5522	Integral membrane protein (intg_mem_TP0381)
ES968_20320	COG1846	Transcriptional regulator
ES968_20325	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
ES968_20330	COG2234	aminopeptidase activity
ES968_20335	COG2357	RelA SpoT domain protein
ES968_20340	COG1575	Belongs to the MenA family. Type 1 subfamily
ES968_20360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
ES968_20365	COG1696	Membrane protein involved in D-alanine export
ES968_20370	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
ES968_20375	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
ES968_20385	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
ES968_20390	COG1486	melibiose metabolic process
ES968_20395	COG1447	Phosphotransferase system cellobiose-specific component IIA
ES968_20400	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES968_20405	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
ES968_20410	COG3711	transcriptional antiterminator
ES968_20410	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
ES968_20420	COG2094	Belongs to the DNA glycosylase MPG family
ES968_20425	COG0753	catalase activity
ES968_20430	COG2814	Major facilitator Superfamily
ES968_20435	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
ES968_20440	COG1131	(ABC) transporter
ES968_20460	COG1595	DNA-templated transcription, initiation
ES968_20465	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
ES968_20475	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
ES968_20480	COG4988	ABC transporter
ES968_20485	COG1294	oxidase, subunit
ES968_20490	COG1271	oxidase subunit
ES968_20495	COG3493	citrate carrier protein
ES968_20500	COG0501	Belongs to the peptidase M48B family
ES968_20510	COG0726	polysaccharide deacetylase
ES968_20515	COG3842	ATPase activity
ES968_20520	COG2508	Transcriptional regulator
ES968_20530	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
ES968_20535	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
ES968_20545	COG4585	Histidine kinase
ES968_20550	COG2197	response regulator
ES968_20555	COG2195	Cleaves the N-terminal amino acid of tripeptides
ES968_20565	COG4894	glucomannan catabolic process
ES968_20570	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ES968_20575	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
ES968_20580	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_20585	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
ES968_20590	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
ES968_20595	COG2610	gluconate transmembrane transporter activity
ES968_20600	COG0500	methyltransferase
ES968_20605	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES968_20620	COG0753	catalase activity
ES968_20620	COG0693	protein deglycase activity
ES968_20625	COG2851	Citrate transporter
ES968_20630	COG2273	Hydrolase Family 16
ES968_20635	COG3711	transcriptional antiterminator
ES968_20645	COG2270	Major facilitator Superfamily
ES968_20650	COG0513	Belongs to the DEAD box helicase family
ES968_20655	COG3401	FG-GAP repeat protein
ES968_20655	COG2755	lipolytic protein G-D-S-L family
ES968_20775	COG0697	spore germination
ES968_20790	COG0589	response to stress
ES968_20820	COG5444	nuclease activity
ES968_20835	COG3507	Belongs to the glycosyl hydrolase 43 family
ES968_20850	COG2986	histidine ammonia-lyase
ES968_20865	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
ES968_20870	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
ES968_20875	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
ES968_20880	COG2390	Transcriptional regulator
ES968_20890	COG3192	ethanolamine utilization protein
ES968_20895	COG2079	MmgE PrpD family protein
ES968_20905	COG1126	abc transporter atp-binding protein
ES968_20910	COG0765	amino acid transport
ES968_20915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
ES968_20930	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
ES968_20935	COG0561	phosphatase activity
ES968_20965	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
ES968_20970	COG5294	Protein conserved in bacteria
ES968_20975	COG0577	efflux transmembrane transporter activity
ES968_20980	COG1136	(ABC) transporter
ES968_20985	COG2205	protein histidine kinase activity
ES968_20990	COG0745	RESPONSE REGULATOR receiver
ES968_20995	COG0191	fructose-bisphosphate aldolase activity
ES968_21000	COG1082	Xylose isomerase domain protein TIM barrel
ES968_21005	COG1082	Xylose isomerase domain protein TIM barrel
ES968_21010	COG0673	inositol 2-dehydrogenase activity
ES968_21015	COG2814	Major facilitator Superfamily
ES968_21020	COG1082	Xylose isomerase domain protein TIM barrel
ES968_21025	COG3962	Belongs to the TPP enzyme family
ES968_21030	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
ES968_21040	COG1012	belongs to the aldehyde dehydrogenase family
ES968_21045	COG1349	DNA-binding transcription factor activity
ES968_21050	COG0667	Aldo Keto reductase
ES968_21070	COG0326	Molecular chaperone. Has ATPase activity
ES968_21085	COG1309	transcriptional regulator
ES968_21090	COG1012	belongs to the aldehyde dehydrogenase family
ES968_21095	COG1714	RDD family
ES968_21105	COG1714	RDD family
ES968_21110	COG2311	Membrane
ES968_21115	COG1917	Cupin 2, conserved barrel domain protein
ES968_21120	COG1309	transcriptional regulator
ES968_21125	COG1028	Short-chain dehydrogenase reductase Sdr
ES968_21130	COG1846	Transcriptional regulator
ES968_21135	COG1380	Effector of murein hydrolase LrgA
ES968_21140	COG1346	cytolysis
ES968_21145	COG5039	Polysaccharide pyruvyl transferase
ES968_21150	COG1929	Belongs to the glycerate kinase type-1 family
ES968_21155	COG1802	Transcriptional regulator
ES968_21160	COG1070	Carbohydrate kinase
ES968_21165	COG2610	gluconate transmembrane transporter activity
ES968_21170	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
ES968_21175	COG0450	alkyl hydroperoxide reductase
ES968_21180	COG3634	alkyl hydroperoxide reductase activity
ES968_21185	COG2723	6-phospho-beta-galactosidase activity
ES968_21200	COG2188	Transcriptional regulator
ES968_21215	COG1131	(ABC) transporter
ES968_21220	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
ES968_21235	COG0071	Belongs to the small heat shock protein (HSP20) family
ES968_21270	COG0210	DNA helicase
ES968_21315	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
ES968_21350	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
ES968_21355	COG0456	acetyltransferase
ES968_21360	COG0457	Tetratricopeptide repeat
ES968_21370	COG0010	Belongs to the arginase family
ES968_21375	COG0833	amino acid
ES968_21380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
ES968_21400	COG5658	integral membrane protein
ES968_21405	COG0640	Transcriptional regulator
ES968_21410	COG3829	transcription factor binding
ES968_21425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
ES968_21430	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
ES968_21435	COG4853	Protein conserved in bacteria
ES968_21440	COG4863	YycH protein
ES968_21445	COG5002	protein histidine kinase activity
ES968_21450	COG0745	RESPONSE REGULATOR receiver
ES968_21480	COG0346	lactoylglutathione lyase activity
ES968_21485	COG0305	Participates in initiation and elongation during chromosome replication
ES968_21500	COG3093	addiction module antidote protein HigA
ES968_21505	COG2807	transmembrane transport
ES968_21510	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
ES968_21515	COG0359	binds to the 23S rRNA
ES968_21520	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
ES968_21540	COG1733	regulation of RNA biosynthetic process
ES968_21545	COG1227	inorganic diphosphatase activity
ES968_21565	COG0789	Transcriptional regulator
ES968_21565	COG4978	Transcriptional regulator
ES968_21575	COG4319	ketosteroid isomerase
ES968_21580	COG1357	PFAM Pentapeptide repeats (8 copies)
ES968_21595	COG1846	Transcriptional regulator
ES968_21600	COG2153	protein acetylation
ES968_21605	COG2364	Membrane
ES968_21610	COG0456	acetyltransferase
ES968_21620	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
ES968_21630	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
ES968_21635	COG1331	Highly conserved protein containing a thioredoxin domain
ES968_21640	COG1266	CAAX protease self-immunity
ES968_21645	COG0477	Major facilitator Superfamily
ES968_21645	COG2814	Major facilitator Superfamily
ES968_21650	COG0110	maltose O-acetyltransferase activity
ES968_21655	COG0346	lactoylglutathione lyase activity
ES968_21660	COG1609	Transcriptional regulator
ES968_21665	COG0708	Exodeoxyribonuclease III
ES968_21670	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
ES968_21675	COG0629	single-stranded DNA binding
ES968_21680	COG0360	Binds together with S18 to 16S ribosomal RNA
ES968_21685	COG0012	GTP binding
ES968_21690	COG0243	molybdopterin cofactor binding
ES968_21695	COG4481	Protein conserved in bacteria
ES968_21700	COG3949	Membrane
ES968_21710	COG1475	DNA binding
ES968_21715	COG1192	Involved in chromosome partitioning
ES968_21725	COG1475	DNA binding
ES968_21730	COG0357	Ribosomal RNA small subunit methyltransferase G
ES968_21735	COG0445	tRNA wobble uridine modification
ES968_21740	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
ES968_21745	COG1847	R3H domain protein
ES968_21750	COG0706	membrane insertase activity
ES968_21755	COG0594	ribonuclease P activity
ES968_21760	COG0230	Belongs to the bacterial ribosomal protein bL34 family
ES968_21775	COG1073	alpha beta
ES968_21780	COG4191	Histidine kinase
ES968_21790	COG1476	TRANSCRIPTIONal
ES968_21875	COG0741	lytic transglycosylase activity
ES968_21875	COG0791	NLP P60 protein
ES968_21940	COG1793	dna ligase
ES968_22100	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
ES968_22115	COG4974	Belongs to the 'phage' integrase family
ES968_22125	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
ES968_22170	COG0582	viral genome integration into host DNA