locus-tag	class	description
PF977_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PF977_00015	COG0594	ribonuclease P activity
PF977_00020	COG0706	membrane insertase activity
PF977_00025	COG1847	R3H domain protein
PF977_00030	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PF977_00035	COG0445	tRNA wobble uridine modification
PF977_00040	COG0357	Ribosomal RNA small subunit methyltransferase G
PF977_00045	COG1475	DNA binding
PF977_00055	COG1192	Involved in chromosome partitioning
PF977_00060	COG1475	DNA binding
PF977_00070	COG3949	Membrane
PF977_00075	COG4481	Protein conserved in bacteria
PF977_00080	COG0243	molybdopterin cofactor binding
PF977_00085	COG0012	GTP binding
PF977_00090	COG0360	Binds together with S18 to 16S ribosomal RNA
PF977_00095	COG0629	single-stranded DNA binding
PF977_00100	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PF977_00105	COG0708	Exodeoxyribonuclease III
PF977_00110	COG1609	Transcriptional regulator
PF977_00115	COG0346	lactoylglutathione lyase activity
PF977_00120	COG0110	maltose O-acetyltransferase activity
PF977_00125	COG0477	Major facilitator Superfamily
PF977_00125	COG2814	Major facilitator Superfamily
PF977_00130	COG1266	CAAX protease self-immunity
PF977_00135	COG1331	Highly conserved protein containing a thioredoxin domain
PF977_00140	COG0697	spore germination
PF977_00145	COG0789	Transcriptional regulator
PF977_00150	COG1331	Highly conserved protein containing a thioredoxin domain
PF977_00155	COG2814	Major facilitator Superfamily
PF977_00165	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PF977_00170	COG2315	Protein conserved in bacteria
PF977_00175	COG0456	acetyltransferase
PF977_00180	COG2364	Membrane
PF977_00185	COG2153	protein acetylation
PF977_00190	COG1846	Transcriptional regulator
PF977_00195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF977_00210	COG2153	protein acetylation
PF977_00215	COG0583	DNA-binding transcription factor activity
PF977_00220	COG2814	Major facilitator Superfamily
PF977_00225	COG1357	PFAM Pentapeptide repeats (8 copies)
PF977_00230	COG4319	ketosteroid isomerase
PF977_00240	COG0789	Transcriptional regulator
PF977_00240	COG4978	Transcriptional regulator
PF977_00245	COG2271	Major facilitator Superfamily
PF977_00260	COG1227	inorganic diphosphatase activity
PF977_00265	COG1733	regulation of RNA biosynthetic process
PF977_00270	COG5577	PFAM Coat F domain
PF977_00280	COG4241	membrane
PF977_00285	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
PF977_00290	COG0359	binds to the 23S rRNA
PF977_00295	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PF977_00300	COG2807	transmembrane transport
PF977_00305	COG3093	addiction module antidote protein HigA
PF977_00320	COG0305	Participates in initiation and elongation during chromosome replication
PF977_00325	COG0346	lactoylglutathione lyase activity
PF977_00355	COG0745	RESPONSE REGULATOR receiver
PF977_00360	COG5002	protein histidine kinase activity
PF977_00365	COG4863	YycH protein
PF977_00370	COG4853	Protein conserved in bacteria
PF977_00375	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
PF977_00380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF977_00395	COG3829	transcription factor binding
PF977_00400	COG0640	Transcriptional regulator
PF977_00405	COG5658	integral membrane protein
PF977_00425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PF977_00430	COG0833	amino acid
PF977_00435	COG0010	Belongs to the arginase family
PF977_00445	COG0457	Tetratricopeptide repeat
PF977_00450	COG0456	acetyltransferase
PF977_00455	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
PF977_00475	COG1063	alcohol dehydrogenase
PF977_00490	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PF977_00505	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
PF977_00520	COG3634	alkyl hydroperoxide reductase activity
PF977_00525	COG0450	alkyl hydroperoxide reductase
PF977_00530	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
PF977_00535	COG2610	gluconate transmembrane transporter activity
PF977_00540	COG1070	Carbohydrate kinase
PF977_00545	COG1802	Transcriptional regulator
PF977_00550	COG1929	Belongs to the glycerate kinase type-1 family
PF977_00555	COG5039	Polysaccharide pyruvyl transferase
PF977_00560	COG1346	cytolysis
PF977_00565	COG1380	Effector of murein hydrolase LrgA
PF977_00570	COG1846	Transcriptional regulator
PF977_00575	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_00580	COG1309	transcriptional regulator
PF977_00585	COG1917	Cupin 2, conserved barrel domain protein
PF977_00590	COG2311	Membrane
PF977_00595	COG1714	RDD family
PF977_00605	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PF977_00610	COG1714	RDD family
PF977_00615	COG1012	belongs to the aldehyde dehydrogenase family
PF977_00620	COG1309	transcriptional regulator
PF977_00625	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_00635	COG0326	Molecular chaperone. Has ATPase activity
PF977_00640	COG2814	Major facilitator Superfamily
PF977_00655	COG0667	Aldo Keto reductase
PF977_00660	COG1349	DNA-binding transcription factor activity
PF977_00665	COG1012	belongs to the aldehyde dehydrogenase family
PF977_00675	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PF977_00680	COG3962	Belongs to the TPP enzyme family
PF977_00685	COG1082	Xylose isomerase domain protein TIM barrel
PF977_00690	COG2814	Major facilitator Superfamily
PF977_00695	COG0673	inositol 2-dehydrogenase activity
PF977_00700	COG1082	Xylose isomerase domain protein TIM barrel
PF977_00705	COG1082	Xylose isomerase domain protein TIM barrel
PF977_00710	COG0191	fructose-bisphosphate aldolase activity
PF977_00715	COG0745	RESPONSE REGULATOR receiver
PF977_00720	COG2205	protein histidine kinase activity
PF977_00725	COG1136	(ABC) transporter
PF977_00730	COG0577	efflux transmembrane transporter activity
PF977_00735	COG5294	Protein conserved in bacteria
PF977_00740	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PF977_00770	COG0561	phosphatase activity
PF977_00775	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
PF977_00780	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF977_00785	COG0456	acetyltransferase
PF977_00790	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF977_00795	COG0765	amino acid transport
PF977_00800	COG1126	abc transporter atp-binding protein
PF977_00805	COG1473	amidohydrolase
PF977_00810	COG2079	MmgE PrpD family protein
PF977_00815	COG3192	ethanolamine utilization protein
PF977_00825	COG2390	Transcriptional regulator
PF977_00830	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
PF977_00835	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PF977_00840	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
PF977_00845	COG0833	amino acid
PF977_00850	COG0010	Belongs to the arginase family
PF977_00855	COG1228	amidohydrolase
PF977_00860	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
PF977_00865	COG2986	histidine ammonia-lyase
PF977_00880	COG3507	Belongs to the glycosyl hydrolase 43 family
PF977_00930	COG1263	PTS System
PF977_00930	COG2190	(PTS) system
PF977_00930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF977_00935	COG2723	6-phospho-beta-galactosidase activity
PF977_00940	COG0589	response to stress
PF977_00945	COG0697	spore germination
PF977_00950	COG3209	COG3209 Rhs family protein
PF977_01010	COG2755	lipolytic protein G-D-S-L family
PF977_01010	COG3401	FG-GAP repeat protein
PF977_01015	COG0513	Belongs to the DEAD box helicase family
PF977_01020	COG2270	Major facilitator Superfamily
PF977_01030	COG3711	transcriptional antiterminator
PF977_01035	COG2273	Hydrolase Family 16
PF977_01040	COG2851	Citrate transporter
PF977_01045	COG0753	catalase activity
PF977_01045	COG0693	protein deglycase activity
PF977_01060	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PF977_01065	COG0500	methyltransferase
PF977_01070	COG2610	gluconate transmembrane transporter activity
PF977_01075	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PF977_01080	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PF977_01085	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_01090	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PF977_01095	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PF977_01100	COG4894	glucomannan catabolic process
PF977_01115	COG2195	Cleaves the N-terminal amino acid of tripeptides
PF977_01120	COG2197	response regulator
PF977_01125	COG4585	Histidine kinase
PF977_01135	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PF977_01145	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF977_01150	COG1012	belongs to the aldehyde dehydrogenase family
PF977_01155	COG2508	Transcriptional regulator
PF977_01160	COG3842	ATPase activity
PF977_01165	COG0726	polysaccharide deacetylase
PF977_01175	COG0501	Belongs to the peptidase M48B family
PF977_01180	COG3493	citrate carrier protein
PF977_01185	COG1271	oxidase subunit
PF977_01190	COG1294	oxidase, subunit
PF977_01195	COG4988	ABC transporter
PF977_01200	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
PF977_01205	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PF977_01210	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PF977_01215	COG1595	DNA-templated transcription, initiation
PF977_01235	COG1131	(ABC) transporter
PF977_01240	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
PF977_01245	COG2814	Major facilitator Superfamily
PF977_01250	COG0753	catalase activity
PF977_01255	COG2094	Belongs to the DNA glycosylase MPG family
PF977_01265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF977_01265	COG3711	transcriptional antiterminator
PF977_01270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PF977_01275	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PF977_01280	COG1447	Phosphotransferase system cellobiose-specific component IIA
PF977_01285	COG1486	melibiose metabolic process
PF977_01290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PF977_01295	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
PF977_01300	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
PF977_01305	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF977_01310	COG1696	Membrane protein involved in D-alanine export
PF977_01315	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_01330	COG1575	Belongs to the MenA family. Type 1 subfamily
PF977_01335	COG2357	RelA SpoT domain protein
PF977_01340	COG2814	Major facilitator Superfamily
PF977_01355	COG2234	aminopeptidase activity
PF977_01360	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PF977_01365	COG1846	Transcriptional regulator
PF977_01370	COG5522	Integral membrane protein (intg_mem_TP0381)
PF977_01375	COG1442	glycosyl transferase family 8
PF977_01380	COG3711	transcriptional antiterminator
PF977_01385	COG1263	PTS System
PF977_01385	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF977_01390	COG1404	Belongs to the peptidase S8 family
PF977_01410	COG0346	lactoylglutathione lyase activity
PF977_01415	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
PF977_01420	COG4895	conserved protein (DUF2196)
PF977_01425	COG2814	Major facilitator Superfamily
PF977_01430	COG1346	cytolysis
PF977_01435	COG1380	Effector of murein hydrolase LrgA
PF977_01440	COG0583	DNA-binding transcription factor activity
PF977_01445	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
PF977_01450	COG0352	thiamine-phosphate diphosphorylase activity
PF977_01455	COG0672	)-iron permease
PF977_01460	COG2822	iron ion transport
PF977_01465	COG2837	iron assimilation
PF977_01470	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
PF977_01475	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF977_01480	COG3162	membrane
PF977_01490	COG1309	transcriptional regulator
PF977_01495	COG2246	polysaccharide biosynthetic process
PF977_01500	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
PF977_01505	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
PF977_01510	COG2261	transglycosylase associated protein
PF977_01515	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PF977_01520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PF977_01525	COG1845	cytochrome c oxidase, subunit III
PF977_01530	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
PF977_01540	COG0772	Belongs to the SEDS family
PF977_01545	COG0778	Nitroreductase
PF977_01550	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF977_01555	COG1404	Belongs to the peptidase S8 family
PF977_01565	COG3711	transcriptional antiterminator
PF977_01570	COG2116	formate transmembrane transporter activity
PF977_01575	COG1263	PTS System
PF977_01575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF977_01580	COG1621	beta-fructofuranosidase activity
PF977_01590	COG0351	phosphomethylpyrimidine kinase
PF977_01595	COG1216	Glycosyl transferase, family 2
PF977_01600	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PF977_01605	COG1012	belongs to the aldehyde dehydrogenase family
PF977_01615	COG2233	PERMEase
PF977_01620	COG2363	Small membrane protein
PF977_01630	COG0463	Glycosyl transferase, family 2
PF977_01635	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
PF977_01640	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PF977_01645	COG0456	acetyltransferase
PF977_01650	COG2089	acid synthase
PF977_01655	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
PF977_01660	COG3980	spore coat polysaccharide biosynthesis protein
PF977_01665	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
PF977_01670	COG1088	dTDP-glucose 4,6-dehydratase activity
PF977_01675	COG1091	dTDP-4-dehydrorhamnose reductase activity
PF977_01680	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
PF977_01690	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PF977_01695	COG1012	belongs to the aldehyde dehydrogenase family
PF977_01700	COG4187	Peptidase family M20/M25/M40
PF977_01705	COG0833	amino acid
PF977_01710	COG2814	Major facilitator Superfamily
PF977_01715	COG0077	Prephenate dehydratase
PF977_01720	COG1917	Cupin 2, conserved barrel domain protein
PF977_01725	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_01730	COG0151	Belongs to the GarS family
PF977_01735	COG2814	Major facilitator Superfamily
PF977_01740	COG0436	Aminotransferase
PF977_01745	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_01750	COG3253	May function as heme-dependent peroxidase
PF977_01755	COG0280	phosphate acetyltransferase
PF977_01760	COG0583	DNA-binding transcription factor activity
PF977_01765	COG0095	Lipoate-protein ligase
PF977_01770	COG0697	spore germination
PF977_01780	COG4844	belongs to the
PF977_01785	COG1078	dGTPase activity
PF977_01790	COG3465	dGTPase activity
PF977_01795	COG1959	2 iron, 2 sulfur cluster binding
PF977_01800	COG0477	Major facilitator Superfamily
PF977_01805	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PF977_01810	COG1846	Transcriptional regulator
PF977_01815	COG1942	4-Oxalocrotonate Tautomerase
PF977_01820	COG1994	Peptidase M50
PF977_01830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PF977_01835	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
PF977_01840	COG0010	Belongs to the arginase family
PF977_01850	COG1131	(ABC) transporter
PF977_01880	COG0457	Tetratricopeptide repeat
PF977_01885	COG3391	amine dehydrogenase activity
PF977_01890	COG3391	amine dehydrogenase activity
PF977_01900	COG0612	Peptidase, M16
PF977_01905	COG0612	Peptidase, M16
PF977_01910	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PF977_01915	COG1131	(ABC) transporter
PF977_01925	COG0535	radical SAM domain protein
PF977_01940	COG4506	Protein conserved in bacteria
PF977_01945	COG0018	arginyl-trna synthetase
PF977_01950	COG2223	nitrite transmembrane transporter activity
PF977_01955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PF977_01965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
PF977_01970	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
PF977_01975	COG1140	nitrate reductase beta subunit
PF977_01980	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
PF977_01985	COG2181	nitrate reductase activity
PF977_01995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF977_02000	COG1132	(ABC) transporter
PF977_02015	COG4294	response to UV
PF977_02020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF977_02025	COG2181	nitrate reductase activity
PF977_02025	COG0247	lactate metabolic process
PF977_02030	COG1960	acyl-CoA dehydrogenase activity
PF977_02035	COG3343	RNA polymerase activity
PF977_02040	COG0504	CTP synthase activity
PF977_02045	COG4821	SIS domain
PF977_02050	COG2204	response regulator
PF977_02055	COG0191	fructose-bisphosphate aldolase activity
PF977_02060	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
PF977_02065	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PF977_02070	COG1494	fructose-1,6-bisphosphatase
PF977_02080	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PF977_02090	COG1435	thymidine kinase activity
PF977_02095	COG0281	malic enzyme
PF977_02100	COG0679	Auxin Efflux Carrier
PF977_02105	COG0789	Transcriptional regulator
PF977_02110	COG0346	lactoylglutathione lyase activity
PF977_02115	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PF977_02120	COG2890	protein-(glutamine-N5) methyltransferase activity
PF977_02140	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
PF977_02145	COG0009	L-threonylcarbamoyladenylate synthase
PF977_02150	COG1971	Probably functions as a manganese efflux pump
PF977_02155	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PF977_02160	COG0698	ribose 5-phosphate isomerase
PF977_02165	COG4475	Protein of unknown function (DUF436)
PF977_02170	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PF977_02175	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PF977_02185	COG0356	it plays a direct role in the translocation of protons across the membrane
PF977_02195	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PF977_02200	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PF977_02205	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
PF977_02210	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PF977_02215	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PF977_02220	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PF977_02230	COG4836	Membrane
PF977_02240	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
PF977_02245	COG2385	sporulation resulting in formation of a cellular spore
PF977_02250	COG2304	oxidoreductase activity
PF977_02260	COG2304	oxidoreductase activity
PF977_02270	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PF977_02275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PF977_02280	COG0457	Tetratricopeptide repeat
PF977_02285	COG1994	Peptidase M50
PF977_02290	COG3237	CsbD-like
PF977_02305	COG0831	urea catabolic process
PF977_02310	COG0832	Belongs to the urease beta subunit family
PF977_02315	COG0804	urea catabolic process
PF977_02320	COG1959	2 iron, 2 sulfur cluster binding
PF977_02325	COG2910	NAD(P)H-binding
PF977_02335	COG0789	Transcriptional regulator
PF977_02340	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
PF977_02360	COG1247	-acetyltransferase
PF977_02365	COG0739	heme binding
PF977_02375	COG0671	phosphoesterase, PA-phosphatase related
PF977_02380	COG0347	Belongs to the P(II) protein family
PF977_02385	COG0004	ammonium transporteR
PF977_02395	COG1335	isochorismatase
PF977_02400	COG0477	Major facilitator Superfamily
PF977_02405	COG1953	Uracil, thiamine, allantoin
PF977_02410	COG3420	alginic acid biosynthetic process
PF977_02415	COG2814	Major facilitator Superfamily
PF977_02420	COG1846	Transcriptional regulator
PF977_02430	COG1609	Transcriptional regulator
PF977_02435	COG1077	Cell shape determining protein MreB Mrl
PF977_02440	COG4786	Flagellar basal body rod
PF977_02445	COG4786	Flagellar basal body rod
PF977_02450	COG0457	Tetratricopeptide repeat
PF977_02455	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PF977_02460	COG1970	mechanosensitive ion channel activity
PF977_02465	COG2972	Histidine kinase
PF977_02465	COG0745	RESPONSE REGULATOR receiver
PF977_02485	COG0629	single-stranded DNA binding
PF977_02490	COG1349	DNA-binding transcription factor activity
PF977_02495	COG0561	phosphatase activity
PF977_02500	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PF977_02505	COG4715	Zinc finger, swim domain protein
PF977_02515	COG3944	biosynthesis protein
PF977_02520	COG0489	protein tyrosine kinase activity
PF977_02525	COG4464	protein tyrosine phosphatase activity
PF977_02530	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PF977_02535	COG3878	Protein conserved in bacteria
PF977_02555	COG5444	nuclease activity
PF977_02570	COG0583	DNA-binding transcription factor activity
PF977_02575	COG0655	NAD(P)H dehydrogenase (quinone) activity
PF977_02585	COG2059	Chromate
PF977_02590	COG2059	Chromate
PF977_02595	COG1522	sequence-specific DNA binding
PF977_02600	COG0405	Gamma-glutamyltransferase
PF977_02610	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF977_02620	COG5337	Spore coat protein CotH
PF977_02635	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
PF977_02640	COG0583	DNA-binding transcription factor activity
PF977_02645	COG0028	Belongs to the TPP enzyme family
PF977_02650	COG3527	Alpha-acetolactate decarboxylase
PF977_02655	COG2249	NAD(P)H dehydrogenase (quinone) activity
PF977_02665	COG3103	Sh3 type 3 domain protein
PF977_02670	COG1879	ABC-type sugar transport system periplasmic component
PF977_02675	COG1172	Belongs to the binding-protein-dependent transport system permease family
PF977_02680	COG1129	ABC transporter
PF977_02685	COG1869	D-ribose catabolic process
PF977_02690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PF977_02695	COG1609	Transcriptional regulator
PF977_02700	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PF977_02710	COG2843	Capsule synthesis protein
PF977_02720	COG0791	NLP P60 protein
PF977_02725	COG0561	phosphatase activity
PF977_02730	COG1316	TRANSCRIPTIONal
PF977_02735	COG2814	Major facilitator Superfamily
PF977_02745	COG0814	amino acid
PF977_02750	COG0697	spore germination
PF977_02755	COG1482	cell wall glycoprotein biosynthetic process
PF977_02760	COG4193	domain, Protein
PF977_02770	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
PF977_02775	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
PF977_02780	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PF977_02785	COG0438	transferase activity, transferring glycosyl groups
PF977_02790	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
PF977_02795	COG1682	transport, permease protein
PF977_02800	COG1134	teichoic acid transport
PF977_02805	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PF977_02810	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
PF977_02815	COG1316	TRANSCRIPTIONal
PF977_02825	COG2385	sporulation resulting in formation of a cellular spore
PF977_02825	COG2247	cell wall binding repeat
PF977_02830	COG2247	cell wall binding repeat
PF977_02830	COG0860	N-Acetylmuramoyl-L-alanine amidase
PF977_02840	COG2244	polysaccharide biosynthetic process
PF977_02845	COG0297	glycogen (starch) synthase activity
PF977_02845	COG0438	transferase activity, transferring glycosyl groups
PF977_02850	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PF977_02855	COG3307	-O-antigen
PF977_02860	COG3206	protein involved in exopolysaccharide biosynthesis
PF977_02865	COG1215	transferase activity, transferring glycosyl groups
PF977_02870	COG0438	transferase activity, transferring glycosyl groups
PF977_02875	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PF977_02880	COG1316	TRANSCRIPTIONal
PF977_02885	COG1739	Uncharacterized protein family UPF0029
PF977_02890	COG4585	Histidine kinase
PF977_02895	COG2197	response regulator
PF977_02900	COG1307	EDD domain protein, DegV family
PF977_02905	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
PF977_02915	COG1040	competence protein
PF977_02925	COG2747	anti-sigma28 factor FlgM
PF977_02930	COG3418	PFAM FlgN family protein
PF977_02935	COG4786	Flagellar basal body rod
PF977_02935	COG1256	bacterial-type flagellum assembly
PF977_02940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PF977_02950	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
PF977_02955	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
PF977_02960	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PF977_02965	COG1334	flagellar protein FlaG
PF977_02970	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
PF977_02975	COG1516	flagellar protein fliS
PF977_02990	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
PF977_02995	COG0653	protein targeting
PF977_03005	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF977_03010	COG2010	Cytochrome c
PF977_03015	COG2884	Cell division ATP-binding protein ftsE
PF977_03020	COG2177	Part of the ABC transporter FtsEX involved in
PF977_03025	COG3409	Peptidoglycan-binding domain 1 protein
PF977_03025	COG0793	Belongs to the peptidase S41A family
PF977_03035	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF977_03040	COG2814	Major facilitator Superfamily
PF977_03045	COG1309	transcriptional regulator
PF977_03050	COG0574	Belongs to the PEP-utilizing enzyme family
PF977_03050	COG3848	Pyruvate phosphate dikinase
PF977_03055	COG4897	Protein conserved in bacteria
PF977_03060	COG0556	nucleotide-excision repair
PF977_03065	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PF977_03085	COG3595	metallopeptidase activity
PF977_03090	COG1983	PspC domain protein
PF977_03095	COG1950	PFAM Membrane protein of
PF977_03100	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PF977_03105	COG2188	Transcriptional regulator
PF977_03110	COG0363	glucosamine-6-phosphate deaminase activity
PF977_03115	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
PF977_03120	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
PF977_03125	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
PF977_03130	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
PF977_03135	COG0546	phosphoglycolate phosphatase activity
PF977_03140	COG0110	maltose O-acetyltransferase activity
PF977_03145	COG5297	Belongs to the glycosyl hydrolase family 6
PF977_03150	COG4990	cell redox homeostasis
PF977_03155	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
PF977_03160	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
PF977_03165	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PF977_03170	COG0131	Imidazoleglycerol-phosphate dehydratase
PF977_03175	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PF977_03180	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PF977_03185	COG0107	imidazoleglycerol-phosphate synthase activity
PF977_03190	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PF977_03190	COG0140	phosphoribosyl-ATP diphosphatase activity
PF977_03210	COG1132	(ABC) transporter
PF977_03215	COG0457	Tetratricopeptide repeat
PF977_03220	COG3883	PFAM NLP P60 protein
PF977_03220	COG0791	NLP P60 protein
PF977_03225	COG0492	ferredoxin-NADP+ reductase activity
PF977_03230	COG1051	belongs to the nudix hydrolase family
PF977_03235	COG1660	Displays ATPase and GTPase activities
PF977_03240	COG0391	Required for morphogenesis under gluconeogenic growth conditions
PF977_03245	COG1481	regulation of sporulation
PF977_03250	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF977_03255	COG2162	N-hydroxyarylamine O-acetyltransferase activity
PF977_03265	COG0745	RESPONSE REGULATOR receiver
PF977_03270	COG5002	protein histidine kinase activity
PF977_03275	COG1136	(ABC) transporter
PF977_03280	COG0577	efflux transmembrane transporter activity
PF977_03285	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PF977_03290	COG0288	reversible hydration of carbon dioxide
PF977_03295	COG0659	secondary active sulfate transmembrane transporter activity
PF977_03300	COG1694	Mazg nucleotide pyrophosphohydrolase
PF977_03305	COG1611	Belongs to the LOG family
PF977_03310	COG1609	Transcriptional regulator
PF977_03315	COG0366	Alpha amylase catalytic
PF977_03320	COG2182	Extracellular solute-binding protein
PF977_03325	COG1175	transmembrane transport
PF977_03330	COG3833	ABC-type maltose transport systems, permease component
PF977_03335	COG5521	maltodextrose utilization protein MalA
PF977_03340	COG1554	hydrolase, family 65, central catalytic
PF977_03345	COG0366	Alpha amylase catalytic
PF977_03350	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PF977_03355	COG0740	serine-type endopeptidase activity
PF977_03365	COG3621	Patatin-like phospholipase
PF977_03370	COG0277	FAD linked oxidase domain protein
PF977_03380	COG2076	Multidrug Resistance protein
PF977_03385	COG2076	Multidrug Resistance protein
PF977_03390	COG1309	transcriptional regulator
PF977_03395	COG0531	amino acid
PF977_03400	COG1621	beta-fructofuranosidase activity
PF977_03405	COG1621	beta-fructofuranosidase activity
PF977_03410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PF977_03425	COG3479	Phenolic acid decarboxylase
PF977_03435	COG2272	Belongs to the type-B carboxylesterase lipase family
PF977_03440	COG1396	sequence-specific DNA binding
PF977_03445	COG3944	biosynthesis protein
PF977_03450	COG0489	protein tyrosine kinase activity
PF977_03455	COG1086	Polysaccharide biosynthesis protein
PF977_03460	COG0438	transferase activity, transferring glycosyl groups
PF977_03465	COG1215	transferase activity, transferring glycosyl groups
PF977_03470	COG0438	transferase activity, transferring glycosyl groups
PF977_03480	COG1216	Glycosyl transferase, family 2
PF977_03485	COG5039	Polysaccharide pyruvyl transferase
PF977_03490	COG1216	Glycosyl transferase, family 2
PF977_03495	COG2244	polysaccharide biosynthetic process
PF977_03500	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PF977_03505	COG0110	maltose O-acetyltransferase activity
PF977_03510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PF977_03515	COG5039	Polysaccharide pyruvyl transferase
PF977_03525	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
PF977_03530	COG1620	l-lactate permease
PF977_03535	COG2186	Transcriptional regulator
PF977_03540	COG1609	Transcriptional regulator
PF977_03545	COG2182	Extracellular solute-binding protein
PF977_03550	COG1175	transmembrane transport
PF977_03555	COG3833	ABC-type maltose transport systems, permease component
PF977_03560	COG1874	Beta-galactosidase
PF977_03565	COG3867	Arabinogalactan endo-beta-1,4-galactanase
PF977_03570	COG2208	phosphoserine phosphatase activity
PF977_03575	COG0596	Alpha beta hydrolase
PF977_03580	COG1131	(ABC) transporter
PF977_03585	COG0842	Transport permease protein
PF977_03590	COG4585	Histidine kinase
PF977_03595	COG2197	response regulator
PF977_03600	COG0247	lactate metabolic process
PF977_03605	COG1139	Iron-sulfur cluster binding protein
PF977_03610	COG1556	Lactate utilization protein
PF977_03615	COG3858	chitin binding
PF977_03620	COG1113	amino acid transport
PF977_03625	COG0697	spore germination
PF977_03630	COG0583	DNA-binding transcription factor activity
PF977_03635	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF977_03640	COG1609	Transcriptional regulator
PF977_03645	COG2814	Major facilitator Superfamily
PF977_03650	COG2390	Transcriptional regulator
PF977_03655	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PF977_03660	COG0126	phosphoglycerate kinase activity
PF977_03665	COG0149	triose-phosphate isomerase activity
PF977_03670	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PF977_03675	COG0148	phosphopyruvate hydratase activity
PF977_03680	COG2234	aminopeptidase activity
PF977_03690	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PF977_03695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF977_03715	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PF977_03730	COG0456	acetyltransferase
PF977_03735	COG4640	response to antibiotic
PF977_03740	COG3064	Membrane
PF977_03750	COG2095	MarC family integral membrane protein
PF977_03755	COG1510	regulation of RNA biosynthetic process
PF977_03760	COG1125	glycine betaine transport
PF977_03760	COG0517	IMP dehydrogenase activity
PF977_03765	COG1174	glycine betaine transport
PF977_03770	COG1732	Glycine betaine
PF977_03775	COG1174	glycine betaine transport
PF977_03780	COG1510	regulation of RNA biosynthetic process
PF977_03785	COG1125	glycine betaine transport
PF977_03785	COG0517	IMP dehydrogenase activity
PF977_03790	COG1174	glycine betaine transport
PF977_03795	COG1732	Glycine betaine
PF977_03800	COG1174	glycine betaine transport
PF977_03805	COG0840	transmembrane signaling receptor activity
PF977_03810	COG1733	regulation of RNA biosynthetic process
PF977_03815	COG1396	sequence-specific DNA binding
PF977_03820	COG1396	sequence-specific DNA binding
PF977_03825	COG1476	TRANSCRIPTIONal
PF977_03830	COG0596	Alpha beta hydrolase
PF977_03835	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PF977_03840	COG1647	Serine aminopeptidase, S33
PF977_03845	COG0557	exoribonuclease II activity
PF977_03850	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PF977_03860	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_03865	COG1309	transcriptional regulator
PF977_03870	COG2076	Multidrug Resistance protein
PF977_03880	COG1289	transmembrane transporter activity
PF977_03885	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PF977_03890	COG0673	inositol 2-dehydrogenase activity
PF977_03895	COG1937	Protein conserved in bacteria
PF977_03900	COG2608	mercury ion transmembrane transporter activity
PF977_03905	COG2217	Heavy metal translocating P-type atpase
PF977_03910	COG2217	Heavy metal translocating P-type atpase
PF977_03915	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
PF977_03920	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PF977_03925	COG2860	membrane
PF977_03930	COG3973	AAA domain
PF977_03935	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PF977_03940	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF977_03945	COG0025	NhaP-type Na H and K H
PF977_03955	COG0656	L-ascorbic acid biosynthetic process
PF977_03960	COG4149	molybdate abc transporter
PF977_03965	COG0725	ABC transporter, periplasmic molybdate-binding protein
PF977_03970	COG1910	domain protein
PF977_03975	COG1368	sulfuric ester hydrolase activity
PF977_03980	COG1988	membrane-bound metal-dependent
PF977_03990	COG0531	amino acid
PF977_03995	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PF977_04000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF977_04005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF977_04010	COG1120	ATPase activity
PF977_04015	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF977_04020	COG1136	(ABC) transporter
PF977_04025	COG0577	efflux transmembrane transporter activity
PF977_04035	COG2140	Oxalate decarboxylase
PF977_04045	COG1191	sigma factor activity
PF977_04055	COG0745	RESPONSE REGULATOR receiver
PF977_04060	COG2205	protein histidine kinase activity
PF977_04065	COG3386	PFAM SMP-30 Gluconolaconase
PF977_04070	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_04075	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PF977_04080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF977_04085	COG1120	ATPase activity
PF977_04090	COG2096	Adenosyltransferase
PF977_04095	COG2814	Major facilitator Superfamily
PF977_04100	COG4758	membrane
PF977_04105	COG1842	Phage shock protein A
PF977_04110	COG3595	metallopeptidase activity
PF977_04115	COG4758	membrane
PF977_04120	COG4585	Histidine kinase
PF977_04125	COG2197	response regulator
PF977_04135	COG0814	amino acid
PF977_04140	COG0697	spore germination
PF977_04150	COG0114	fumarate hydratase activity
PF977_04155	COG1309	transcriptional regulator
PF977_04165	COG2770	Histidine kinase
PF977_04165	COG2205	protein histidine kinase activity
PF977_04170	COG0745	RESPONSE REGULATOR receiver
PF977_04175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF977_04180	COG0783	Belongs to the Dps family
PF977_04185	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_04200	COG1120	ATPase activity
PF977_04210	COG0583	DNA-binding transcription factor activity
PF977_04215	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_04220	COG1942	4-Oxalocrotonate Tautomerase
PF977_04225	COG0477	Major facilitator Superfamily
PF977_04230	COG1846	Transcriptional regulator
PF977_04235	COG5577	PFAM Coat F domain
PF977_04245	COG0506	proline dehydrogenase activity
PF977_04255	COG1250	3-hydroxyacyl-CoA dehydrogenase
PF977_04255	COG1024	Enoyl-CoA hydratase
PF977_04260	COG0183	Belongs to the thiolase family
PF977_04265	COG1960	acyl-CoA dehydrogenase activity
PF977_04270	COG1393	Belongs to the ArsC family
PF977_04275	COG0509	glycine decarboxylation via glycine cleavage system
PF977_04285	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
PF977_04290	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF977_04300	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PF977_04305	COG2011	ABC-type metal ion transport system permease component
PF977_04310	COG1464	Belongs to the NlpA lipoprotein family
PF977_04315	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PF977_04325	COG0396	ATPase activity
PF977_04330	COG0719	Fe-S assembly protein
PF977_04335	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PF977_04340	COG0822	iron-sulfur transferase activity
PF977_04345	COG0719	Fe-S assembly protein
PF977_04360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF977_04365	COG0322	excinuclease ABC activity
PF977_04370	COG2222	sugar isomerase
PF977_04375	COG1653	transport
PF977_04380	COG1175	transmembrane transport
PF977_04385	COG0395	ABC-type sugar transport system, permease component
PF977_04390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PF977_04395	COG2188	Transcriptional regulator
PF977_04400	COG3842	ATPase activity
PF977_04405	COG2356	endonuclease I
PF977_04415	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PF977_04420	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
PF977_04425	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
PF977_04430	COG2068	MobA-Related Protein
PF977_04435	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
PF977_04440	COG1529	Aldehyde oxidase and xanthine dehydrogenase
PF977_04445	COG2080	2 iron, 2 sulfur cluster binding
PF977_04455	COG2351	hydroxyisourate hydrolase activity
PF977_04460	COG3648	Uricase
PF977_04460	COG3195	allantoin biosynthetic process
PF977_04465	COG2233	PERMEase
PF977_04470	COG2233	PERMEase
PF977_04475	COG2508	Transcriptional regulator
PF977_04480	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PF977_04490	COG1801	Protein of unknown function DUF72
PF977_04495	COG0730	response to heat
PF977_04500	COG0737	Belongs to the 5'-nucleotidase family
PF977_04505	COG3377	Domain of unknown function (DUF1805)
PF977_04515	COG0739	heme binding
PF977_04520	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
PF977_04530	COG4470	Protein conserved in bacteria
PF977_04535	COG2445	Protein of unknown function DUF86
PF977_04540	COG0647	UMP catabolic process
PF977_04545	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PF977_04550	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PF977_04555	COG0460	homoserine dehydrogenase
PF977_04560	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PF977_04565	COG0083	homoserine kinase activity
PF977_04570	COG4946	Tricorn protease homolog
PF977_04570	COG1506	peptidase
PF977_04570	COG0823	Involved in the tonB-independent uptake of proteins
PF977_04575	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
PF977_04580	COG4837	Protein of unknown function (DUF1462)
PF977_04585	COG1252	NADH dehydrogenase
PF977_04590	COG4844	belongs to the
PF977_04595	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
PF977_04600	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
PF977_04605	COG0316	Belongs to the HesB IscA family
PF977_04610	COG0456	acetyltransferase
PF977_04615	COG2808	Putative FMN-binding domain
PF977_04620	COG0516	GMP reductase activity
PF977_04630	COG0492	ferredoxin-NADP+ reductase activity
PF977_04635	COG1252	NADH dehydrogenase
PF977_04650	COG3584	3D domain protein
PF977_04655	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
PF977_04660	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PF977_04665	COG2056	Na+-H+ antiporter family
PF977_04670	COG1268	BioY protein
PF977_04675	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PF977_04680	COG2819	hydrolase of the alpha beta superfamily
PF977_04685	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_04690	COG1169	isochorismate synthase
PF977_04695	COG1021	2,3-dihydroxybenzoate-AMP ligase
PF977_04700	COG1535	isochorismatase
PF977_04700	COG3433	isochorismatase activity
PF977_04705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_04710	COG3251	PFAM MbtH domain protein
PF977_04715	COG5634	Uncharacterized conserved protein (DUF2278)
PF977_04720	COG0686	Belongs to the AlaDH PNT family
PF977_04725	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
PF977_04725	COG2508	Transcriptional regulator
PF977_04730	COG4842	Belongs to the WXG100 family
PF977_04735	COG5417	Belongs to the EsaB family
PF977_04740	COG4499	WXG100 protein secretion system (Wss), protein YukC
PF977_04745	COG0433	COG0433 Predicted ATPase
PF977_04745	COG1674	ftsk spoiiie
PF977_04750	COG1511	domain protein
PF977_04760	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_04765	COG1418	mRNA catabolic process
PF977_04780	COG0628	permease
PF977_04795	COG5506	Protein of unknown function (DUF1694)
PF977_04800	COG1335	isochorismatase
PF977_04805	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
PF977_04810	COG3434	signal transduction protein containing EAL and modified HD-GYP domains
PF977_04830	COG0142	geranyltranstransferase activity
PF977_04840	COG4585	Histidine kinase
PF977_04845	COG2197	response regulator
PF977_04850	COG2050	protein possibly involved in aromatic compounds catabolism
PF977_04855	COG1320	monovalent cation:proton antiporter activity
PF977_04860	COG2212	antiporter activity
PF977_04865	COG1863	multisubunit Na H antiporter MnhE subunit
PF977_04870	COG0651	ATP synthesis coupled electron transport
PF977_04875	COG1006	Multisubunit Na H antiporter MnhC subunit
PF977_04880	COG2111	Na H antiporter
PF977_04885	COG2111	Na H antiporter
PF977_04885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PF977_04895	COG3493	citrate carrier protein
PF977_04900	COG1079	Belongs to the binding-protein-dependent transport system permease family
PF977_04905	COG4603	Belongs to the binding-protein-dependent transport system permease family
PF977_04910	COG3845	ABC transporter
PF977_04915	COG1744	ABC transporter substrate-binding protein PnrA-like
PF977_04920	COG4565	transcriptional regulatory protein
PF977_04925	COG3290	protein histidine kinase activity
PF977_04935	COG3011	Protein conserved in bacteria
PF977_04940	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PF977_04945	COG2814	Major facilitator Superfamily
PF977_04955	COG5018	Exonuclease
PF977_04965	COG2205	protein histidine kinase activity
PF977_04970	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
PF977_04980	COG2267	carboxylic ester hydrolase activity
PF977_04985	COG1522	sequence-specific DNA binding
PF977_04990	COG0436	Aminotransferase
PF977_04995	COG1098	S1 RNA binding domain
PF977_05000	COG2155	Conserved Protein
PF977_05005	COG1979	alcohol dehydrogenase
PF977_05010	COG1979	alcohol dehydrogenase
PF977_05015	COG0166	Belongs to the GPI family
PF977_05030	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PF977_05045	COG2738	Putative neutral zinc metallopeptidase
PF977_05050	COG1253	flavin adenine dinucleotide binding
PF977_05055	COG0366	Alpha amylase catalytic
PF977_05065	COG0432	Pfam Uncharacterised protein family UPF0047
PF977_05080	COG0840	transmembrane signaling receptor activity
PF977_05085	COG0840	transmembrane signaling receptor activity
PF977_05090	COG0840	transmembrane signaling receptor activity
PF977_05095	COG0840	transmembrane signaling receptor activity
PF977_05100	COG3347	Dehydrogenase
PF977_05100	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_05105	COG1349	DNA-binding transcription factor activity
PF977_05110	COG1070	Carbohydrate kinase
PF977_05115	COG3254	rhamnose metabolic process
PF977_05120	COG4806	L-rhamnose isomerase
PF977_05125	COG0673	inositol 2-dehydrogenase activity
PF977_05130	COG0628	permease
PF977_05135	COG1968	undecaprenyl-diphosphatase activity
PF977_05145	COG5553	Cysteine dioxygenase type I
PF977_05150	COG0477	Major facilitator Superfamily
PF977_05155	COG1705	Flagellar rod assembly protein muramidase FlgJ
PF977_05160	COG4682	membrane
PF977_05165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PF977_05170	COG0569	domain protein
PF977_05180	COG1510	regulation of RNA biosynthetic process
PF977_05185	COG1012	belongs to the aldehyde dehydrogenase family
PF977_05190	COG1454	alcohol dehydrogenase
PF977_05200	COG2318	DinB family
PF977_05205	COG1585	Membrane protein implicated in regulation of membrane protease activity
PF977_05210	COG2268	Band 7 protein
PF977_05215	COG1247	-acetyltransferase
PF977_05220	COG3859	Proton-coupled thiamine transporter YuaJ
PF977_05345	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
PF977_05350	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PF977_05355	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
PF977_05360	COG0297	glycogen (starch) synthase activity
PF977_05365	COG0058	SHG alpha-glucan phosphorylase activity
PF977_05370	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
PF977_05375	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PF977_05380	COG0438	transferase activity, transferring glycosyl groups
PF977_05385	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PF977_05395	COG0438	transferase activity, transferring glycosyl groups
PF977_05400	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF977_05405	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
PF977_05410	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PF977_05415	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PF977_05420	COG1169	isochorismate synthase
PF977_05425	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
PF977_05430	COG0596	Alpha beta hydrolase
PF977_05435	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
PF977_05440	COG0318	PFAM AMP-dependent synthetase and ligase
PF977_05445	COG4948	Mandelate Racemase Muconate Lactonizing
PF977_05450	COG0803	Belongs to the bacterial solute-binding protein 9 family
PF977_05455	COG1121	(ABC) transporter
PF977_05460	COG1321	iron dependent repressor
PF977_05460	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PF977_05465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PF977_05475	COG1294	oxidase, subunit
PF977_05480	COG1271	oxidase subunit
PF977_05485	COG0254	rRNA binding
PF977_05490	COG0288	reversible hydration of carbon dioxide
PF977_05495	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PF977_05500	COG1854	S-ribosylhomocysteine lyase activity
PF977_05515	COG0783	Belongs to the Dps family
PF977_05520	COG4824	toxin secretion phage lysis holin
PF977_05525	COG0494	nUDIX hydrolase
PF977_05530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF977_05535	COG1116	anion transmembrane transporter activity
PF977_05540	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF977_05545	COG1506	peptidase
PF977_05555	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
PF977_05560	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PF977_05565	COG0367	asparagine synthase
PF977_05570	COG1113	amino acid transport
PF977_05575	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
PF977_05580	COG2267	carboxylic ester hydrolase activity
PF977_05590	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
PF977_05595	COG1242	4 iron, 4 sulfur cluster binding
PF977_05610	COG1725	Transcriptional regulator
PF977_05615	COG1131	(ABC) transporter
PF977_05630	COG1136	(ABC) transporter
PF977_05635	COG0577	efflux transmembrane transporter activity
PF977_05640	COG0745	RESPONSE REGULATOR receiver
PF977_05645	COG2205	protein histidine kinase activity
PF977_05650	COG1136	(ABC) transporter
PF977_05655	COG0577	efflux transmembrane transporter activity
PF977_05660	COG2433	Pfam Transposase IS66
PF977_05665	COG2814	Major facilitator Superfamily
PF977_05670	COG2202	Pas domain
PF977_05670	COG1366	Belongs to the anti-sigma-factor antagonist family
PF977_05680	COG0495	leucyl-tRNA aminoacylation
PF977_05685	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PF977_05690	COG1486	melibiose metabolic process
PF977_05695	COG0395	ABC-type sugar transport system, permease component
PF977_05700	COG1175	transmembrane transport
PF977_05705	COG1653	transport
PF977_05710	COG1609	Transcriptional regulator
PF977_05715	COG1073	alpha beta
PF977_05725	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PF977_05730	COG0156	8-amino-7-oxononanoate synthase activity
PF977_05740	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PF977_05745	COG2124	cytochrome p450
PF977_05750	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF977_05755	COG0395	ABC-type sugar transport system, permease component
PF977_05760	COG1653	transport
PF977_05765	COG2207	Transcriptional regulator
PF977_05770	COG4209	transmembrane transport
PF977_05775	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
PF977_05780	COG1653	transport
PF977_05785	COG0673	inositol 2-dehydrogenase activity
PF977_05790	COG5578	integral membrane protein
PF977_05800	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
PF977_05805	COG2081	HI0933 family
PF977_05810	COG2244	polysaccharide biosynthetic process
PF977_05815	COG1187	pseudouridine synthase activity
PF977_05820	COG1349	DNA-binding transcription factor activity
PF977_05825	COG1131	(ABC) transporter
PF977_05830	COG4473	ABC transporter
PF977_05835	COG2252	PERMEase
PF977_05840	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PF977_05845	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PF977_05850	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
PF977_05860	COG1597	lipid kinase activity
PF977_05865	COG1523	belongs to the glycosyl hydrolase 13 family
PF977_05870	COG0510	thiamine kinase activity
PF977_05880	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PF977_05885	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF977_05890	COG0281	malic enzyme
PF977_05895	COG5584	Small secreted protein
PF977_05900	COG1363	Peptidase, m42
PF977_05915	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF977_05920	COG4848	Belongs to the UPF0354 family
PF977_05925	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF977_05930	COG1674	ftsk spoiiie
PF977_05935	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
PF977_05940	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
PF977_05945	COG4980	gas vesicle protein
PF977_05950	COG3118	belongs to the thioredoxin family
PF977_05955	COG1605	Chorismate mutase
PF977_05955	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
PF977_05960	COG1609	Transcriptional regulator
PF977_05965	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PF977_05970	COG1360	Flagellar Motor Protein
PF977_05975	COG0123	including yeast histone deacetylase and acetoin utilization protein
PF977_05980	COG0517	IMP dehydrogenase activity
PF977_05985	COG0454	-acetyltransferase
PF977_05990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF977_05995	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PF977_06005	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PF977_06010	COG2203	Gaf domain
PF977_06010	COG2199	diguanylate cyclase activity
PF977_06015	COG1956	GAF domain-containing protein
PF977_06020	COG1309	transcriptional regulator
PF977_06025	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
PF977_06030	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
PF977_06035	COG1114	Component of the transport system for branched-chain amino acids
PF977_06040	COG1104	cysteine desulfurase activity
PF977_06045	COG0301	tRNA thio-modification
PF977_06055	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PF977_06060	COG1574	metal-dependent hydrolase with the TIM-barrel fold
PF977_06065	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PF977_06070	COG0616	signal peptide processing
PF977_06075	COG1714	RDD family
PF977_06085	COG3874	Sporulation protein YtfJ
PF977_06090	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
PF977_06095	COG0827	DNA restriction-modification system
PF977_06105	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
PF977_06110	COG0521	Mo-molybdopterin cofactor biosynthetic process
PF977_06115	COG0137	argininosuccinate synthase activity
PF977_06120	COG0165	Argininosuccinate lyase
PF977_06130	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_06135	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
PF977_06140	COG0583	DNA-binding transcription factor activity
PF977_06145	COG0454	-acetyltransferase
PF977_06150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF977_06155	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF977_06160	COG0765	amino acid transport
PF977_06165	COG0765	amino acid transport
PF977_06170	COG1126	abc transporter atp-binding protein
PF977_06175	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF977_06180	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
PF977_06185	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF977_06190	COG0196	riboflavin kinase activity
PF977_06195	COG1473	amidohydrolase
PF977_06200	COG0730	response to heat
PF977_06205	COG4109	DRTGG domain
PF977_06215	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
PF977_06235	COG0587	DNA-directed DNA polymerase activity
PF977_06240	COG0281	malic enzyme
PF977_06245	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PF977_06250	COG0825	malonyl-CoA metabolic process
PF977_06255	COG0205	6-phosphofructokinase activity
PF977_06260	COG0469	pyruvate kinase activity
PF977_06265	COG3030	protein affecting phage T7 exclusion by the F plasmid
PF977_06270	COG0628	permease
PF977_06275	COG2707	UPF0756 membrane protein
PF977_06280	COG0372	Belongs to the citrate synthase family
PF977_06285	COG0538	isocitrate dehydrogenase activity
PF977_06290	COG0039	L-malate dehydrogenase activity
PF977_06295	COG0745	RESPONSE REGULATOR receiver
PF977_06300	COG5002	protein histidine kinase activity
PF977_06305	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PF977_06305	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PF977_06310	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
PF977_06315	COG1971	Probably functions as a manganese efflux pump
PF977_06320	COG0237	dephospho-CoA kinase activity
PF977_06325	COG0656	L-ascorbic acid biosynthetic process
PF977_06330	COG2814	Major facilitator Superfamily
PF977_06335	COG1733	regulation of RNA biosynthetic process
PF977_06340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PF977_06345	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
PF977_06350	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
PF977_06355	COG3611	Membrane attachment protein
PF977_06360	COG1484	DNA-dependent DNA replication
PF977_06365	COG0398	Pfam SNARE associated Golgi protein
PF977_06375	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PF977_06380	COG1011	Hydrolase
PF977_06385	COG3275	phosphorelay sensor kinase activity
PF977_06390	COG3279	Response regulator of the LytR AlgR family
PF977_06395	COG1380	Effector of murein hydrolase LrgA
PF977_06400	COG1346	cytolysis
PF977_06410	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PF977_06415	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PF977_06420	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PF977_06425	COG3326	Membrane
PF977_06435	COG1363	Peptidase, m42
PF977_06440	COG3507	Belongs to the glycosyl hydrolase 43 family
PF977_06445	COG2160	L-arabinose isomerase activity
PF977_06450	COG1069	ribulokinase activity
PF977_06455	COG0235	Class ii aldolase
PF977_06460	COG0647	UMP catabolic process
PF977_06465	COG0371	Dehydrogenase
PF977_06470	COG1653	transport
PF977_06475	COG1175	transmembrane transport
PF977_06480	COG0395	ABC-type sugar transport system, permease component
PF977_06485	COG3534	alpha-L-arabinofuranosidase
PF977_06490	COG1966	Carbon starvation protein
PF977_06500	COG0346	lactoylglutathione lyase activity
PF977_06505	COG0247	lactate metabolic process
PF977_06510	COG0277	FAD linked oxidase domain protein
PF977_06515	COG3835	regulator
PF977_06525	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PF977_06535	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PF977_06540	COG0072	phenylalanine-tRNA ligase activity
PF977_06540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF977_06545	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PF977_06550	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
PF977_06555	COG1286	toxin biosynthetic process
PF977_06560	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
PF977_06560	COG1796	DNA polymerase
PF977_06565	COG1193	negative regulation of DNA recombination
PF977_06570	COG3766	membrane
PF977_06575	COG0318	PFAM AMP-dependent synthetase and ligase
PF977_06580	COG1309	transcriptional regulator
PF977_06585	COG1024	Enoyl-CoA hydratase
PF977_06590	COG2086	electron transfer activity
PF977_06595	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
PF977_06600	COG3534	alpha-L-arabinofuranosidase
PF977_06605	COG3118	belongs to the thioredoxin family
PF977_06610	COG0322	excinuclease ABC activity
PF977_06615	COG0527	aspartate kinase activity
PF977_06620	COG1719	4-vinyl reductase, 4VR
PF977_06625	COG2009	succinate dehydrogenase
PF977_06630	COG1053	succinate dehydrogenase
PF977_06635	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PF977_06640	COG0824	Thioesterase
PF977_06645	COG2197	response regulator
PF977_06650	COG1846	Transcriptional regulator
PF977_06655	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PF977_06660	COG5401	PFAM Sporulation and spore germination
PF977_06665	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
PF977_06670	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PF977_06675	COG0622	Phosphoesterase
PF977_06685	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
PF977_06690	COG0454	-acetyltransferase
PF977_06700	COG0028	Belongs to the TPP enzyme family
PF977_06705	COG0440	acetolactate synthase activity
PF977_06710	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PF977_06715	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PF977_06720	COG0473	3-isopropylmalate dehydrogenase activity
PF977_06725	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
PF977_06730	COG0066	3-isopropylmalate dehydratase activity
PF977_06735	COG1477	protein flavinylation
PF977_06735	COG0457	Tetratricopeptide repeat
PF977_06740	COG0544	peptidyl-prolyl cis-trans isomerase activity
PF977_06745	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PF977_06750	COG0470	DNA polymerase III
PF977_06750	COG1067	ATP-dependent peptidase activity
PF977_06755	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PF977_06760	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PF977_06770	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PF977_06775	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PF977_06780	COG0181	hydroxymethylbilane synthase activity
PF977_06785	COG1587	Uroporphyrinogen-III synthase
PF977_06790	COG0113	porphobilinogen synthase activity
PF977_06795	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PF977_06800	COG1388	LysM domain
PF977_06805	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PF977_06815	COG0525	valine-tRNA ligase activity
PF977_06820	COG0285	dihydrofolate synthase activity
PF977_06825	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
PF977_06835	COG0424	maF-like protein
PF977_06840	COG2003	Belongs to the UPF0758 family
PF977_06845	COG1077	Cell shape determining protein MreB Mrl
PF977_06855	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
PF977_06860	COG0850	regulation of cytokinetic process
PF977_06865	COG2894	cell division
PF977_06870	COG0739	heme binding
PF977_06875	COG1994	Peptidase M50
PF977_06880	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PF977_06885	COG2868	ribosomal protein
PF977_06890	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PF977_06900	COG3290	protein histidine kinase activity
PF977_06905	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PF977_06910	COG4492	Belongs to the UPF0735 family
PF977_06915	COG0077	Prephenate dehydratase
PF977_06920	COG1827	regulation of RNA biosynthetic process
PF977_06925	COG1104	cysteine desulfurase activity
PF977_06930	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
PF977_06935	COG0157	Belongs to the NadC ModD family
PF977_06940	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
PF977_06945	COG1388	LysM domain
PF977_06955	COG0217	transcriptional regulatory protein
PF977_06960	COG1115	amino acid carrier protein
PF977_06985	COG2112	serine threonine protein kinase
PF977_06990	COG0673	inositol 2-dehydrogenase activity
PF977_06995	COG2814	Major facilitator Superfamily
PF977_07005	COG0632	four-way junction helicase activity
PF977_07010	COG2255	four-way junction helicase activity
PF977_07020	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PF977_07025	COG0343	queuine tRNA-ribosyltransferase activity
PF977_07030	COG1862	Preprotein translocase
PF977_07040	COG2323	membrane
PF977_07045	COG2244	polysaccharide biosynthetic process
PF977_07055	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PF977_07055	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PF977_07060	COG0490	domain, Protein
PF977_07065	COG5416	Lipopolysaccharide assembly protein A domain
PF977_07070	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PF977_07070	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
PF977_07075	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PF977_07080	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PF977_07085	COG1490	D-aminoacyl-tRNA deacylase activity
PF977_07090	COG0860	N-Acetylmuramoyl-L-alanine amidase
PF977_07090	COG3103	Sh3 type 3 domain protein
PF977_07090	COG4991	sh3 domain protein
PF977_07100	COG0124	histidyl-tRNA synthetase
PF977_07105	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PF977_07115	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
PF977_07120	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PF977_07125	COG1959	2 iron, 2 sulfur cluster binding
PF977_07130	COG1104	cysteine desulfurase activity
PF977_07135	COG0482	sulfurtransferase activity
PF977_07140	COG0457	Tetratricopeptide repeat
PF977_07145	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PF977_07150	COG3881	PFAM PRC-barrel domain
PF977_07165	COG0765	amino acid transport
PF977_07170	COG0765	amino acid transport
PF977_07175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF977_07180	COG1126	abc transporter atp-binding protein
PF977_07185	COG0628	permease
PF977_07190	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PF977_07195	COG4472	Bacterial protein of unknown function (DUF965)
PF977_07200	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
PF977_07205	COG3906	Belongs to the UPF0473 family
PF977_07210	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PF977_07215	COG4122	O-methyltransferase activity
PF977_07220	COG0826	peptidase U32
PF977_07225	COG0826	peptidase U32
PF977_07230	COG0572	uridine kinase
PF977_07235	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
PF977_07240	COG0768	penicillin binding
PF977_07255	COG2226	methyltransferase
PF977_07260	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PF977_07265	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PF977_07270	COG0626	cystathionine gamma-synthase activity
PF977_07280	COG2427	Protein of unknown function (DUF1641)
PF977_07285	COG3383	formate dehydrogenase (NAD+) activity
PF977_07290	COG5609	conserved protein (DUF2294)
PF977_07295	COG2116	formate transmembrane transporter activity
PF977_07310	COG2226	methyltransferase
PF977_07315	COG1309	transcriptional regulator
PF977_07320	COG2124	cytochrome p450
PF977_07320	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PF977_07330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF977_07335	COG1131	(ABC) transporter
PF977_07355	COG2084	Dehydrogenase
PF977_07360	COG2986	histidine ammonia-lyase
PF977_07365	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PF977_07370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PF977_07410	COG1378	Sugar-specific transcriptional regulator TrmB
PF977_07415	COG1280	lysine exporter protein (LysE YggA)
PF977_07420	COG1113	amino acid transport
PF977_07430	COG3933	PFAM sigma-54 factor interaction domain-containing protein
PF977_07430	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
PF977_07435	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF977_07440	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF977_07445	COG3715	PTS system
PF977_07450	COG3716	PTS system mannose fructose sorbose family IID component
PF977_07460	COG1621	beta-fructofuranosidase activity
PF977_07465	COG0693	protein deglycase activity
PF977_07470	COG1064	alcohol dehydrogenase
PF977_07480	COG0789	Transcriptional regulator
PF977_07485	COG5577	PFAM Coat F domain
PF977_07495	COG1063	alcohol dehydrogenase
PF977_07500	COG5577	PFAM Coat F domain
PF977_07510	COG0346	lactoylglutathione lyase activity
PF977_07520	COG4991	sh3 domain protein
PF977_07525	COG4991	sh3 domain protein
PF977_07530	COG0596	Alpha beta hydrolase
PF977_07535	COG5566	PFAM Mor transcription activator
PF977_07540	COG3409	Peptidoglycan-binding domain 1 protein
PF977_07545	COG2828	Protein conserved in bacteria
PF977_07550	COG0583	DNA-binding transcription factor activity
PF977_07555	COG2851	Citrate transporter
PF977_07560	COG0667	Aldo Keto reductase
PF977_07565	COG1595	DNA-templated transcription, initiation
PF977_07570	COG3443	Belongs to the bacterial solute-binding protein 9 family
PF977_07585	COG2315	Protein conserved in bacteria
PF977_07590	COG4978	Transcriptional regulator
PF977_07590	COG0789	Transcriptional regulator
PF977_07600	COG3959	Transketolase, thiamine diphosphate binding domain
PF977_07605	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PF977_07610	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_07625	COG2186	Transcriptional regulator
PF977_07635	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PF977_07645	COG2070	2-Nitropropane dioxygenase
PF977_07655	COG2318	DinB family
PF977_07670	COG1335	isochorismatase
PF977_07680	COG2124	cytochrome p450
PF977_07690	COG1522	sequence-specific DNA binding
PF977_07695	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
PF977_07700	COG1687	branched-chain amino acid
PF977_07705	COG1114	Component of the transport system for branched-chain amino acids
PF977_07715	COG0583	DNA-binding transcription factor activity
PF977_07720	COG1942	4-Oxalocrotonate Tautomerase
PF977_07725	COG1230	cation diffusion facilitator family transporter
PF977_07730	COG2072	flavoprotein involved in K transport
PF977_07735	COG0583	DNA-binding transcription factor activity
PF977_07740	COG0697	spore germination
PF977_07750	COG1253	flavin adenine dinucleotide binding
PF977_07755	COG0456	acetyltransferase
PF977_07760	COG2814	Major facilitator Superfamily
PF977_07765	COG4978	Transcriptional regulator
PF977_07765	COG0789	Transcriptional regulator
PF977_07780	COG0662	Cupin 2, conserved barrel domain protein
PF977_07790	COG1937	Protein conserved in bacteria
PF977_07795	COG2210	Belongs to the sulfur carrier protein TusA family
PF977_07800	COG0425	Belongs to the sulfur carrier protein TusA family
PF977_07800	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PF977_07815	COG0425	Belongs to the sulfur carrier protein TusA family
PF977_07820	COG0730	response to heat
PF977_07825	COG4124	Belongs to the glycosyl hydrolase 26 family
PF977_07845	COG2856	Zn peptidase
PF977_07850	COG0563	adenylate kinase activity
PF977_07860	COG3620	sequence-specific DNA binding
PF977_07865	COG1476	TRANSCRIPTIONal
PF977_07895	COG5377	YqaJ viral recombinase family
PF977_07900	COG3723	Recombinational DNA repair protein, rece pathway
PF977_07905	COG3935	DnaD domain protein
PF977_07910	COG1484	DNA-dependent DNA replication
PF977_07920	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
PF977_07940	COG3677	Transposase
PF977_07955	COG5484	DNA packaging
PF977_07960	COG1783	phage Terminase large subunit
PF977_07965	COG5518	Phage portal protein
PF977_07970	COG2369	cell adhesion
PF977_07980	COG0338	D12 class N6 adenine-specific DNA methyltransferase
PF977_07985	COG4653	Phage capsid family
PF977_08045	COG5280	Phage tail tape measure protein TP901
PF977_08045	COG3953	SLT domain
PF977_08050	COG1652	LysM domain
PF977_08055	COG4193	domain, Protein
PF977_08065	COG3628	GPW Gp25 family protein
PF977_08075	COG3778	Protein conserved in bacteria
PF977_08105	COG4824	toxin secretion phage lysis holin
PF977_08110	COG5632	N-Acetylmuramoyl-L-alanine amidase
PF977_08110	COG3409	Peptidoglycan-binding domain 1 protein
PF977_08135	COG5444	nuclease activity
PF977_08150	COG0457	Tetratricopeptide repeat
PF977_08170	COG1331	Highly conserved protein containing a thioredoxin domain
PF977_08175	COG0604	alcohol dehydrogenase
PF977_08195	COG3403	YqcI/YcgG family
PF977_08200	COG0640	Transcriptional regulator
PF977_08205	COG0346	lactoylglutathione lyase activity
PF977_08210	COG0798	PFAM Bile acid sodium symporter
PF977_08215	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PF977_08225	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PF977_08235	COG3209	COG3209 Rhs family protein
PF977_08245	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
PF977_08250	COG0398	Pfam SNARE associated Golgi protein
PF977_08255	COG5632	N-Acetylmuramoyl-L-alanine amidase
PF977_08255	COG3409	Peptidoglycan-binding domain 1 protein
PF977_08260	COG2755	lipolytic protein G-D-S-L family
PF977_08270	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
PF977_08275	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
PF977_08280	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PF977_08285	COG1534	Rna-binding protein
PF977_08290	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
PF977_08295	COG1713	HD superfamily hydrolase involved in NAD metabolism
PF977_08300	COG0799	negative regulation of ribosome biogenesis
PF977_08305	COG2226	methyltransferase
PF977_08310	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PF977_08315	COG1596	polysaccharide export
PF977_08315	COG1555	photosystem II stabilization
PF977_08320	COG2131	deaminase
PF977_08325	COG0658	competence protein
PF977_08325	COG2333	competence protein COMEC
PF977_08340	COG1466	dna polymerase III delta subunit
PF977_08345	COG0268	Binds directly to 16S ribosomal RNA
PF977_08350	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
PF977_08355	COG0860	N-Acetylmuramoyl-L-alanine amidase
PF977_08365	COG0481	GTPase activity
PF977_08370	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PF977_08375	COG1420	regulation of RNA biosynthetic process
PF977_08380	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PF977_08385	COG0443	Heat shock 70 kDa protein
PF977_08390	COG0484	heat shock protein binding
PF977_08395	COG2264	protein methyltransferase activity
PF977_08400	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PF977_08405	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PF977_08410	COG1283	sodium-dependent phosphate transmembrane transporter activity
PF977_08420	COG1610	YqeY-like protein
PF977_08425	COG1030	water channel activity
PF977_08430	COG4864	UPF0365 protein
PF977_08445	COG0561	phosphatase activity
PF977_08450	COG1702	phosphate starvation-inducible protein PhoH
PF977_08455	COG1480	7TM receptor with intracellular HD hydrolase
PF977_08460	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
PF977_08465	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
PF977_08470	COG0295	cytidine deaminase activity
PF977_08475	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PF977_08485	COG1381	Involved in DNA repair and RecF pathway recombination
PF977_08490	COG0752	glycyl-tRNA synthetase alpha subunit
PF977_08495	COG0751	glycine-tRNA ligase activity
PF977_08500	COG0517	IMP dehydrogenase activity
PF977_08505	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
PF977_08510	COG1671	Belongs to the UPF0178 family
PF977_08515	COG0358	DNA primase activity
PF977_08520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PF977_08525	COG2010	Cytochrome c
PF977_08530	COG2384	SAM-dependent methyltransferase
PF977_08535	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PF977_08540	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PF977_08550	COG0513	Belongs to the DEAD box helicase family
PF977_08555	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
PF977_08565	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF977_08570	COG0735	belongs to the Fur family
PF977_08575	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
PF977_08580	COG4709	membrane
PF977_08585	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PF977_08590	COG1388	LysM domain
PF977_08595	COG5521	maltodextrose utilization protein MalA
PF977_08600	COG2839	Protein conserved in bacteria
PF977_08605	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PF977_08610	COG0477	Major facilitator Superfamily
PF977_08615	COG0768	penicillin binding
PF977_08620	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PF977_08625	COG0573	inorganic phosphate transmembrane transporter activity
PF977_08630	COG0581	inorganic phosphate transmembrane transporter activity
PF977_08635	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PF977_08640	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PF977_08645	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
PF977_08660	COG0438	transferase activity, transferring glycosyl groups
PF977_08670	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
PF977_08680	COG0457	Tetratricopeptide repeat
PF977_08680	COG0705	Rhomboid family
PF977_08685	COG4483	Protein conserved in bacteria
PF977_08690	COG1940	carbohydrate kinase activity
PF977_08695	COG1368	sulfuric ester hydrolase activity
PF977_08700	COG2866	Carboxypeptidase
PF977_08710	COG0011	TIGRFAM Protein of
PF977_08720	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF977_08730	COG1393	Belongs to the ArsC family
PF977_08740	COG1366	Belongs to the anti-sigma-factor antagonist family
PF977_08745	COG1253	flavin adenine dinucleotide binding
PF977_08750	COG0598	Magnesium transport protein CorA
PF977_08755	COG0517	IMP dehydrogenase activity
PF977_08760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PF977_08765	COG1459	type II secretion system
PF977_08770	COG4537	Required for transformation and DNA binding
PF977_08775	COG4970	Tfp pilus assembly protein FimT
PF977_08785	COG4940	Competence protein ComGF
PF977_08810	COG0681	Belongs to the peptidase S26 family
PF977_08820	COG1396	sequence-specific DNA binding
PF977_08835	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
PF977_08840	COG0404	The glycine cleavage system catalyzes the degradation of glycine
PF977_08845	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PF977_08850	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
PF977_08855	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PF977_08860	COG0095	Lipoate-protein ligase
PF977_08865	COG1321	iron dependent repressor
PF977_08870	COG1752	Esterase of the alpha-beta hydrolase superfamily
PF977_08880	COG3872	metal-dependent enzyme
PF977_08890	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PF977_08895	COG0006	proline dipeptidase activity
PF977_08900	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PF977_08910	COG3854	ATPases associated with a variety of cellular activities
PF977_08950	COG0511	ligase activity, forming carbon-carbon bonds
PF977_08955	COG0439	Biotin carboxylase
PF977_08960	COG1302	Protein conserved in bacteria
PF977_08965	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PF977_08970	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
PF977_08975	COG1570	exodeoxyribonuclease VII activity
PF977_08980	COG1722	exodeoxyribonuclease VII activity
PF977_08985	COG0142	geranyltranstransferase activity
PF977_08990	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PF977_08995	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
PF977_09000	COG1438	arginine binding
PF977_09005	COG0497	DNA recombination
PF977_09010	COG0750	zinc metalloprotease
PF977_09015	COG0745	RESPONSE REGULATOR receiver
PF977_09020	COG1902	pentaerythritol trinitrate reductase activity
PF977_09035	COG0860	N-Acetylmuramoyl-L-alanine amidase
PF977_09040	COG0584	glycerophosphoryl diester phosphodiesterase
PF977_09045	COG0183	Belongs to the thiolase family
PF977_09050	COG1250	3-hydroxyacyl-CoA dehydrogenase
PF977_09055	COG1960	acyl-CoA dehydrogenase activity
PF977_09060	COG0372	Belongs to the citrate synthase family
PF977_09065	COG2079	MmgE PrpD family protein
PF977_09070	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
PF977_09080	COG3290	protein histidine kinase activity
PF977_09080	COG3829	transcription factor binding
PF977_09085	COG0280	phosphate acetyltransferase
PF977_09090	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PF977_09095	COG3426	butyrate kinase activity
PF977_09100	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF977_09105	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PF977_09110	COG0022	dehydrogenase e1 component
PF977_09115	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF977_09120	COG0789	Transcriptional regulator
PF977_09120	COG4978	Transcriptional regulator
PF977_09125	COG2814	Major facilitator Superfamily
PF977_09130	COG1597	lipid kinase activity
PF977_09140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF977_09145	COG0765	amino acid transport
PF977_09150	COG1126	abc transporter atp-binding protein
PF977_09155	COG4129	membrane
PF977_09160	COG1376	ErfK ybiS ycfS ynhG family protein
PF977_09170	COG0346	lactoylglutathione lyase activity
PF977_09175	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PF977_09180	COG2195	Cleaves the N-terminal amino acid of tripeptides
PF977_09185	COG3361	conserved protein (COG2071)
PF977_09190	COG0706	membrane insertase activity
PF977_09200	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PF977_09205	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
PF977_09210	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
PF977_09215	COG1234	tRNA 3'-trailer cleavage
PF977_09225	COG0596	Alpha beta hydrolase
PF977_09230	COG1902	pentaerythritol trinitrate reductase activity
PF977_09235	COG4187	Peptidase family M20/M25/M40
PF977_09240	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PF977_09245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF977_09250	COG0300	oxidoreductase activity
PF977_09255	COG3048	D-serine ammonia-lyase activity
PF977_09260	COG1072	(Pantothenic acid kinase))
PF977_09265	COG0346	lactoylglutathione lyase activity
PF977_09275	COG2211	Major facilitator Superfamily
PF977_09285	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PF977_09295	COG0456	acetyltransferase
PF977_09300	COG2329	Antibiotic biosynthesis monooxygenase
PF977_09305	COG0456	acetyltransferase
PF977_09305	COG2320	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A
PF977_09310	COG4918	Iron-sulphur cluster biosynthesis
PF977_09320	COG1073	alpha beta
PF977_09330	COG0667	Aldo Keto reductase
PF977_09340	COG0494	nUDIX hydrolase
PF977_09345	COG1379	DNA repair
PF977_09350	COG1396	sequence-specific DNA binding
PF977_09355	COG0252	asparaginase activity
PF977_09360	COG1027	Aspartate ammonia-lyase
PF977_09365	COG1757	Na H antiporter
PF977_09370	COG0281	malic enzyme
PF977_09380	COG1300	Membrane
PF977_09385	COG0735	belongs to the Fur family
PF977_09395	COG4974	Belongs to the 'phage' integrase family
PF977_09400	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
PF977_09405	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
PF977_09410	COG1686	Belongs to the peptidase S11 family
PF977_09415	COG1366	Belongs to the anti-sigma-factor antagonist family
PF977_09420	COG2172	sigma factor antagonist activity
PF977_09425	COG1191	sigma factor activity
PF977_09445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PF977_09460	COG0697	spore germination
PF977_09465	COG0019	diaminopimelate decarboxylase activity
PF977_09470	COG4086	secreted protein
PF977_09475	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PF977_09495	COG2433	Pfam Transposase IS66
PF977_09510	COG3478	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082)
PF977_09520	COG0681	Belongs to the peptidase S26 family
PF977_09530	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PF977_09530	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PF977_09535	COG0307	riboflavin synthase, alpha
PF977_09540	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PF977_09540	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PF977_09545	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PF977_09550	COG0456	acetyltransferase
PF977_09555	COG1547	Domain of unknown function (DUF309)
PF977_09560	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
PF977_09565	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
PF977_09575	COG1686	Belongs to the peptidase S11 family
PF977_09580	COG2715	membrane protein required for spore maturation
PF977_09585	COG0700	Nucleoside recognition
PF977_09590	COG1187	pseudouridine synthase activity
PF977_09595	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF977_09600	COG1333	cytochrome c biogenesis protein
PF977_09605	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PF977_09610	COG0745	RESPONSE REGULATOR receiver
PF977_09615	COG5002	protein histidine kinase activity
PF977_09620	COG1595	DNA-templated transcription, initiation
PF977_09630	COG0710	3-dehydroquinate dehydratase activity
PF977_09635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PF977_09640	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
PF977_09645	COG1141	Ferredoxin
PF977_09650	COG4955	Helix-turn-helix domain
PF977_09655	COG0514	ATP-dependent DNA helicase (RecQ)
PF977_09660	COG1266	CAAX protease self-immunity
PF977_09665	COG1388	LysM domain
PF977_09675	COG1408	metallophosphoesterase
PF977_09680	COG4862	establishment of competence for transformation
PF977_09685	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
PF977_09690	COG0492	ferredoxin-NADP+ reductase activity
PF977_09695	COG2339	peptidase activity
PF977_09700	COG3773	Cell wall hydrolase
PF977_09700	COG3409	Peptidoglycan-binding domain 1 protein
PF977_09705	COG2959	enzyme of heme biosynthesis
PF977_09710	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
PF977_09720	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
PF977_09725	COG0539	negative regulation of cytoplasmic translation
PF977_09730	COG1304	FMN binding
PF977_09755	COG1160	GTP binding
PF977_09760	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
PF977_09775	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
PF977_09780	COG0776	regulation of translation
PF977_09785	COG0302	gtp cyclohydrolase
PF977_09795	COG0142	geranyltranstransferase activity
PF977_09800	COG2226	methyltransferase
PF977_09805	COG0142	geranyltranstransferase activity
PF977_09810	COG0105	UTP biosynthetic process
PF977_09815	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PF977_09820	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PF977_09825	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
PF977_09830	COG4401	Chorismate mutase type I
PF977_09835	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PF977_09840	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PF977_09850	COG0135	phosphoribosylanthranilate isomerase activity
PF977_09855	COG0133	tryptophan synthase activity
PF977_09860	COG0159	tryptophan synthase activity
PF977_09865	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PF977_09870	COG0287	Prephenate dehydrogenase
PF977_09875	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PF977_09880	COG0457	Tetratricopeptide repeat
PF977_09885	COG5582	Belongs to the UPF0302 family
PF977_09895	COG0723	plastoquinol--plastocyanin reductase activity
PF977_09900	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PF977_09905	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PF977_09905	COG2010	Cytochrome c
PF977_09910	COG4347	Protein of unknown function (DUF1405)
PF977_09920	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF977_09925	COG1694	Mazg nucleotide pyrophosphohydrolase
PF977_09930	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PF977_09935	COG1803	Methylglyoxal synthase
PF977_09940	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PF977_09945	COG0438	transferase activity, transferring glycosyl groups
PF977_09950	COG0617	tRNA 3'-terminal CCA addition
PF977_09955	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
PF977_09955	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
PF977_09960	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
PF977_09965	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
PF977_09970	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
PF977_09975	COG1199	ATP-dependent helicase activity
PF977_09975	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
PF977_09985	COG5353	protein conserved in bacteria
PF977_09990	COG0436	Aminotransferase
PF977_09995	COG0017	Asparaginyl-tRNA synthetase
PF977_10000	COG3935	DnaD domain protein
PF977_10005	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PF977_10015	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PF977_10015	COG4499	WXG100 protein secretion system (Wss), protein YukC
PF977_10020	COG3331	DNA recombination
PF977_10055	COG0071	Belongs to the small heat shock protein (HSP20) family
PF977_10060	COG2190	(PTS) system
PF977_10065	COG1111	helicase
PF977_10065	COG1205	dead DEAH box helicase
PF977_10070	COG3359	exonuclease
PF977_10085	COG4474	Belongs to the UPF0398 family
PF977_10100	COG0116	Belongs to the methyltransferase superfamily
PF977_10115	COG1199	ATP-dependent helicase activity
PF977_10120	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_10125	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
PF977_10130	COG1609	Transcriptional regulator
PF977_10135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PF977_10140	COG0800	Aldolase
PF977_10150	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
PF977_10155	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PF977_10160	COG2233	PERMEase
PF977_10165	COG3424	synthase
PF977_10170	COG1755	Isoprenylcysteine carboxyl methyltransferase
PF977_10180	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
PF977_10195	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
PF977_10205	COG0328	RNA-DNA hybrid ribonuclease activity
PF977_10210	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
PF977_10215	COG0328	RNA-DNA hybrid ribonuclease activity
PF977_10235	COG1278	Cold shock
PF977_10245	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PF977_10250	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
PF977_10255	COG0386	Belongs to the glutathione peroxidase family
PF977_10260	COG1418	mRNA catabolic process
PF977_10265	COG1413	lyase activity
PF977_10270	COG0129	dihydroxy-acid dehydratase activity
PF977_10280	COG2136	Putative SAM-dependent methyltransferase
PF977_10280	COG2521	methyltransferase
PF977_10290	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PF977_10295	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PF977_10300	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PF977_10305	COG0204	Acyl-transferase
PF977_10310	COG1272	protein, Hemolysin III
PF977_10315	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
PF977_10320	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PF977_10330	COG1999	signal sequence binding
PF977_10335	COG2755	lipolytic protein G-D-S-L family
PF977_10340	COG4698	Protein conserved in bacteria
PF977_10350	COG0534	Mate efflux family protein
PF977_10355	COG1846	Transcriptional regulator
PF977_10360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PF977_10365	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PF977_10370	COG1086	Polysaccharide biosynthesis protein
PF977_10375	COG4247	3-phytase (myo-inositol-hexaphosphate 3-phosphohydrolase)
PF977_10380	COG4641	Protein conserved in bacteria
PF977_10395	COG0463	Glycosyl transferase, family 2
PF977_10400	COG0456	acetyltransferase
PF977_10415	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PF977_10420	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
PF977_10425	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
PF977_10430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PF977_10435	COG0456	acetyltransferase
PF977_10440	COG1509	lysine 2,3-aminomutase activity
PF977_10450	COG4479	Belongs to the UPF0346 family
PF977_10470	COG0671	phosphoesterase, PA-phosphatase related
PF977_10485	COG0813	purine-nucleoside phosphorylase activity
PF977_10490	COG1876	peptidase activity
PF977_10500	COG2226	methyltransferase
PF977_10505	COG3409	Peptidoglycan-binding domain 1 protein
PF977_10505	COG0793	Belongs to the peptidase S41A family
PF977_10510	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF977_10520	COG0346	lactoylglutathione lyase activity
PF977_10525	COG0400	carboxylic ester hydrolase activity
PF977_10530	COG0778	Nitroreductase
PF977_10535	COG1733	regulation of RNA biosynthetic process
PF977_10540	COG1942	4-Oxalocrotonate Tautomerase
PF977_10545	COG2610	gluconate transmembrane transporter activity
PF977_10560	COG2962	Rard protein
PF977_10570	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PF977_10575	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
PF977_10580	COG1366	Belongs to the anti-sigma-factor antagonist family
PF977_10585	COG0534	Mate efflux family protein
PF977_10590	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
PF977_10595	COG1819	glycosyl
PF977_10600	COG0791	NLP P60 protein
PF977_10600	COG1388	LysM domain
PF977_10605	COG2032	superoxide dismutase activity
PF977_10610	COG0714	Associated with various cellular activities
PF977_10615	COG4548	von Willebrand factor, type A
PF977_10620	COG0567	Dehydrogenase, E1 component
PF977_10625	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF977_10630	COG0385	Bile acid
PF977_10635	COG0733	neurotransmitter:sodium symporter activity
PF977_10640	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PF977_10645	COG1657	PFAM Prenyltransferase squalene oxidase
PF977_10650	COG1012	belongs to the aldehyde dehydrogenase family
PF977_10675	COG0071	Belongs to the small heat shock protein (HSP20) family
PF977_10690	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PF977_10695	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
PF977_10705	COG0514	ATP-dependent DNA helicase (RecQ)
PF977_10710	COG1388	LysM domain
PF977_10710	COG3584	3D domain protein
PF977_10715	COG2197	response regulator
PF977_10720	COG4585	Histidine kinase
PF977_10725	COG3239	Fatty acid desaturase
PF977_10730	COG1619	proteins homologs of microcin C7 resistance protein MccF
PF977_10745	COG2322	membrane
PF977_10750	COG0741	lytic transglycosylase activity
PF977_10755	COG0640	Transcriptional regulator
PF977_10765	COG2378	regulation of single-species biofilm formation
PF977_10770	COG3708	Transcriptional regulator
PF977_10775	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF977_10780	COG1309	transcriptional regulator
PF977_10785	COG0456	acetyltransferase
PF977_10790	COG2207	Transcriptional regulator
PF977_10790	COG0662	Cupin 2, conserved barrel domain protein
PF977_10795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF977_10805	COG3646	Phage regulatory protein
PF977_10805	COG3645	SOS response
PF977_10930	COG5280	Phage tail tape measure protein TP901
PF977_10930	COG3953	SLT domain
PF977_10945	COG5434	Belongs to the glycosyl hydrolase 28 family
PF977_10965	COG4824	toxin secretion phage lysis holin
PF977_10970	COG5632	N-Acetylmuramoyl-L-alanine amidase
PF977_11010	COG0582	viral genome integration into host DNA
PF977_11015	COG5434	Belongs to the glycosyl hydrolase 28 family
PF977_11020	COG1231	oxidoreductase activity
PF977_11025	COG4282	regulation of fungal-type cell wall biogenesis
PF977_11060	COG2314	TM2 domain
PF977_11065	COG0726	polysaccharide deacetylase
PF977_11070	COG0574	Belongs to the PEP-utilizing enzyme family
PF977_11070	COG3848	Pyruvate phosphate dikinase
PF977_11095	COG2367	Beta-lactamase
PF977_11100	COG0693	protein deglycase activity
PF977_11110	COG0697	spore germination
PF977_11115	COG0583	DNA-binding transcription factor activity
PF977_11120	COG3739	integral membrane protein
PF977_11125	COG3655	Transcriptional regulator
PF977_11135	COG2720	vancomycin resistance protein
PF977_11155	COG0456	acetyltransferase
PF977_11165	COG2140	Oxalate decarboxylase
PF977_11175	COG2135	peptidase activity
PF977_11180	COG3866	Pectate lyase
PF977_11185	COG3619	membrane
PF977_11190	COG4305	rare lipoprotein A
PF977_11195	COG2368	4-hydroxyphenylacetate
PF977_11200	COG5278	phosphoserine phosphatase activity
PF977_11200	COG0840	transmembrane signaling receptor activity
PF977_11230	COG0243	molybdopterin cofactor binding
PF977_11235	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PF977_11240	COG1070	Carbohydrate kinase
PF977_11245	COG2814	Major facilitator Superfamily
PF977_11260	COG4768	protein containing a divergent version of the methyl-accepting chemotaxis-like domain
PF977_11265	COG0300	oxidoreductase activity
PF977_11275	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PF977_11280	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PF977_11285	COG0583	DNA-binding transcription factor activity
PF977_11290	COG0070	glutamate synthase
PF977_11290	COG0069	glutamate synthase activity
PF977_11290	COG0067	glutamate synthase
PF977_11295	COG0493	'glutamate synthase
PF977_11300	COG0604	alcohol dehydrogenase
PF977_11305	COG0583	DNA-binding transcription factor activity
PF977_11310	COG0405	Gamma-glutamyltransferase
PF977_11315	COG0166	Belongs to the GPI family
PF977_11320	COG0582	viral genome integration into host DNA
PF977_11335	COG0534	Mate efflux family protein
PF977_11340	COG2017	converts alpha-aldose to the beta-anomer
PF977_11345	COG2027	D-alanyl-D-alanine carboxypeptidase
PF977_11350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_11355	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_11360	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_11365	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_11370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_11370	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
PF977_11380	COG1649	PFAM Uncharacterised BCR, COG1649
PF977_11395	COG1960	acyl-CoA dehydrogenase activity
PF977_11400	COG0318	PFAM AMP-dependent synthetase and ligase
PF977_11405	COG0439	Biotin carboxylase
PF977_11410	COG0511	ligase activity, forming carbon-carbon bonds
PF977_11415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PF977_11420	COG1024	Enoyl-CoA hydratase
PF977_11425	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
PF977_11430	COG2404	hydrolase activity, acting on ester bonds
PF977_11435	COG0586	Pfam SNARE associated Golgi protein
PF977_11440	COG1210	Utp--glucose-1-phosphate uridylyltransferase
PF977_11445	COG2246	polysaccharide biosynthetic process
PF977_11450	COG3507	Belongs to the glycosyl hydrolase 43 family
PF977_11455	COG5520	Belongs to the glycosyl hydrolase 30 family
PF977_11470	COG1115	amino acid carrier protein
PF977_11485	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PF977_11490	COG0187	DNA topoisomerase II activity
PF977_11495	COG1832	CoA-binding protein
PF977_11500	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
PF977_11505	COG4841	protein insertion into membrane
PF977_11515	COG0824	Thioesterase
PF977_11535	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF977_11540	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
PF977_11555	COG0071	Belongs to the small heat shock protein (HSP20) family
PF977_11565	COG4846	Membrane protein involved in cytochrome C biogenesis
PF977_11570	COG2201	protein-glutamate methylesterase activity
PF977_11575	COG0785	Cytochrome C biogenesis protein
PF977_11585	COG3763	UPF0154 protein
PF977_11595	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PF977_11600	COG4224	UPF0291 protein
PF977_11605	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
PF977_11610	COG1388	LysM domain
PF977_11615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
PF977_11635	COG4195	phage-related replication protein
PF977_11670	COG0697	spore germination
PF977_11685	COG3832	glyoxalase III activity
PF977_11700	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PF977_11740	COG0756	dUTP diphosphatase activity
PF977_11750	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PF977_11755	COG2814	Major facilitator Superfamily
PF977_11760	COG1525	nuclease
PF977_11770	COG1070	Carbohydrate kinase
PF977_11775	COG2115	Belongs to the xylose isomerase family
PF977_11780	COG1940	carbohydrate kinase activity
PF977_11785	COG3507	Belongs to the glycosyl hydrolase 43 family
PF977_11790	COG2211	Major facilitator Superfamily
PF977_11805	COG0135	phosphoribosylanthranilate isomerase activity
PF977_11820	COG3655	Transcriptional regulator
PF977_11835	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PF977_11855	COG0463	Glycosyl transferase, family 2
PF977_11900	COG1388	LysM domain
PF977_11900	COG3409	Peptidoglycan-binding domain 1 protein
PF977_11900	COG5632	N-Acetylmuramoyl-L-alanine amidase
PF977_11905	COG4824	toxin secretion phage lysis holin
PF977_11925	COG5434	Belongs to the glycosyl hydrolase 28 family
PF977_11940	COG3953	SLT domain
PF977_11940	COG5412	phage tail tape measure protein
PF977_12100	COG3645	SOS response
PF977_12100	COG3646	Phage regulatory protein
PF977_12120	COG4974	Belongs to the 'phage' integrase family
PF977_12125	COG0174	glutamine synthetase
PF977_12130	COG0789	Transcriptional regulator
PF977_12135	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
PF977_12140	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
PF977_12160	COG3331	DNA recombination
PF977_12210	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
PF977_12240	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
PF977_12245	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
PF977_12270	COG0756	dUTP diphosphatase activity
PF977_12275	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF977_12310	COG1780	Probably involved in ribonucleotide reductase function
PF977_12395	COG0270	DNA (cytosine-5-)-methyltransferase activity
PF977_12410	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PF977_12435	COG3584	3D domain protein
PF977_12440	COG0587	DNA-directed DNA polymerase activity
PF977_12445	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
PF977_12450	COG0358	DNA primase activity
PF977_12455	COG0305	Participates in initiation and elongation during chromosome replication
PF977_12465	COG2887	Belongs to the helicase family. UvrD subfamily
PF977_12510	COG2135	peptidase activity
PF977_12515	COG1793	dna ligase
PF977_12525	COG5484	DNA packaging
PF977_12525	COG3728	DNA packaging
PF977_12655	COG3655	Transcriptional regulator
PF977_12670	COG0582	viral genome integration into host DNA
PF977_12760	COG3655	Transcriptional regulator
PF977_12830	COG1395	domain, Protein
PF977_12845	COG0776	regulation of translation
PF977_12970	COG0584	glycerophosphoryl diester phosphodiesterase
PF977_12985	COG0582	viral genome integration into host DNA
PF977_13025	COG0739	heme binding
PF977_13025	COG0741	lytic transglycosylase activity
PF977_13025	COG1196	nuclear chromosome segregation
PF977_13035	COG2433	Pfam Transposase IS66
PF977_13045	COG5434	Belongs to the glycosyl hydrolase 28 family
PF977_13050	COG5632	N-Acetylmuramoyl-L-alanine amidase
PF977_13050	COG3409	Peptidoglycan-binding domain 1 protein
PF977_13065	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PF977_13070	COG0463	Glycosyl transferase, family 2
PF977_13075	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF977_13080	COG3271	cysteine-type peptidase activity
PF977_13080	COG2274	protein secretion by the type I secretion system
PF977_13095	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
PF977_13115	COG0457	Tetratricopeptide repeat
PF977_13135	COG5444	nuclease activity
PF977_13140	COG4282	regulation of fungal-type cell wall biogenesis
PF977_13150	COG1525	nuclease
PF977_13170	COG0860	N-Acetylmuramoyl-L-alanine amidase
PF977_13175	COG4112	unkown
PF977_13180	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PF977_13185	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PF977_13190	COG1780	Probably involved in ribonucleotide reductase function
PF977_13205	COG1923	regulation of RNA biosynthetic process
PF977_13210	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
PF977_13225	COG2076	Multidrug Resistance protein
PF977_13230	COG2076	Multidrug Resistance protein
PF977_13235	COG1764	response to oxidative stress
PF977_13240	COG4195	phage-related replication protein
PF977_13250	COG1404	Belongs to the peptidase S8 family
PF977_13255	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF977_13265	COG2124	cytochrome p450
PF977_13270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF977_13270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
PF977_13270	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
PF977_13270	COG3321	synthase
PF977_13275	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_13275	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_13275	COG3321	synthase
PF977_13275	COG4221	oxidoreductase activity
PF977_13280	COG3321	synthase
PF977_13280	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_13280	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF977_13280	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF977_13280	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_13285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF977_13285	COG0300	oxidoreductase activity
PF977_13285	COG3321	synthase
PF977_13285	COG4221	oxidoreductase activity
PF977_13290	COG0300	oxidoreductase activity
PF977_13290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_13290	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_13290	COG3321	synthase
PF977_13290	COG0318	PFAM AMP-dependent synthetase and ligase
PF977_13295	COG1024	Enoyl-CoA hydratase
PF977_13300	COG1024	Enoyl-CoA hydratase
PF977_13305	COG3425	synthase
PF977_13310	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PF977_13315	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PF977_13320	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PF977_13320	COG2070	2-Nitropropane dioxygenase
PF977_13325	COG3321	synthase
PF977_13330	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PF977_13340	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF977_13345	COG3226	Transcriptional regulator
PF977_13360	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
PF977_13365	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
PF977_13375	COG4550	Control of competence regulator ComK, YlbF/YmcA
PF977_13380	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PF977_13385	COG0156	8-amino-7-oxononanoate synthase activity
PF977_13390	COG1063	alcohol dehydrogenase
PF977_13395	COG2359	stage V sporulation protein S
PF977_13400	COG1692	metallophosphoesterase
PF977_13405	COG1418	mRNA catabolic process
PF977_13410	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PF977_13415	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PF977_13420	COG1546	Belongs to the CinA family
PF977_13420	COG1058	Belongs to the CinA family
PF977_13425	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
PF977_13430	COG1426	Protein conserved in bacteria
PF977_13445	COG0300	oxidoreductase activity
PF977_13450	COG0612	Peptidase, M16
PF977_13455	COG0612	Peptidase, M16
PF977_13460	COG2814	Major facilitator Superfamily
PF977_13465	COG2188	Transcriptional regulator
PF977_13470	COG1674	ftsk spoiiie
PF977_13470	COG4980	gas vesicle protein
PF977_13480	COG0740	serine-type endopeptidase activity
PF977_13485	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
PF977_13490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF977_13495	COG0527	aspartate kinase activity
PF977_13500	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PF977_13505	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PF977_13510	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PF977_13515	COG1873	PFAM PRC-barrel domain
PF977_13520	COG0612	Peptidase, M16
PF977_13525	COG0726	polysaccharide deacetylase
PF977_13530	COG1185	polyribonucleotide nucleotidyltransferase activity
PF977_13535	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PF977_13540	COG0196	riboflavin kinase activity
PF977_13545	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
PF977_13550	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
PF977_13555	COG1550	Protein conserved in bacteria
PF977_13560	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
PF977_13565	COG1358	cellular component organization or biogenesis
PF977_13570	COG2740	Nucleic-acid-binding protein implicated in transcription termination
PF977_13575	COG0195	Participates in both transcription termination and antitermination
PF977_13580	COG0779	Required for maturation of 30S ribosomal subunits
PF977_13585	COG2176	DNA-directed DNA polymerase activity
PF977_13590	COG0442	prolyl-tRNA aminoacylation
PF977_13595	COG0750	zinc metalloprotease
PF977_13600	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PF977_13605	COG4589	Belongs to the CDS family
PF977_13610	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
PF977_13615	COG0233	cytoplasmic translational termination
PF977_13620	COG0528	UMP kinase activity
PF977_13625	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PF977_13630	COG0052	Belongs to the universal ribosomal protein uS2 family
PF977_13640	COG1191	sigma factor activity
PF977_13645	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
PF977_13650	COG1776	CheC inhibitor of MCP methylation
PF977_13655	COG0835	chemotaxis
PF977_13660	COG2198	Histidine kinase
PF977_13660	COG0643	Histidine kinase
PF977_13665	COG2201	protein-glutamate methylesterase activity
PF977_13670	COG0455	bacterial-type flagellum organization
PF977_13675	COG1419	protein localization to endoplasmic reticulum
PF977_13680	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PF977_13685	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PF977_13690	COG1684	flagellar biosynthetic protein fliR
PF977_13695	COG1987	bacterial-type flagellum assembly
PF977_13700	COG1338	Plays a role in the flagellum-specific transport system
PF977_13705	COG3190	flagellar
PF977_13710	COG2201	protein-glutamate methylesterase activity
PF977_13715	COG1776	CheC inhibitor of MCP methylation
PF977_13715	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PF977_13720	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PF977_13725	COG1580	Controls the rotational direction of flagella during chemotaxis
PF977_13730	COG1582	Flagellar protein (FlbD)
PF977_13735	COG4786	Flagellar basal body rod
PF977_13740	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
PF977_13745	COG3144	bacterial-type flagellum assembly
PF977_13750	COG3334	PFAM MgtE intracellular
PF977_13755	COG2882	bacterial-type flagellum organization
PF977_13760	COG1157	protein secretion by the type III secretion system
PF977_13765	COG1317	bacterial-type flagellum organization
PF977_13770	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PF977_13775	COG1766	The M ring may be actively involved in energy transduction
PF977_13780	COG1677	Flagellar hook-basal body complex protein FliE
PF977_13785	COG1558	bacterial-type flagellum-dependent cell motility
PF977_13790	COG1815	bacterial-type flagellum-dependent cell motility
PF977_13795	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
PF977_13800	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PF977_13805	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PF977_13810	COG4974	Belongs to the 'phage' integrase family
PF977_13815	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
PF977_13820	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PF977_13825	COG0758	DNA mediated transformation
PF977_13830	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PF977_13835	COG0045	succinate-CoA ligase (ADP-forming) activity
PF977_13840	COG2257	FlhB HrpN YscU SpaS Family
PF977_13850	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PF977_13855	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
PF977_13860	COG0335	large ribosomal subunit rRNA binding
PF977_13865	COG0336	Belongs to the RNA methyltransferase TrmD family
PF977_13870	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PF977_13880	COG1837	Belongs to the UPF0109 family
PF977_13885	COG0228	four-way junction DNA binding
PF977_13890	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PF977_13895	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
PF977_13905	COG0552	protein localization to endoplasmic reticulum
PF977_13910	COG1196	nuclear chromosome segregation
PF977_13915	COG0571	ribonuclease III activity
PF977_13925	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_13930	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PF977_13935	COG0416	fatty acid biosynthetic process
PF977_13940	COG2050	protein possibly involved in aromatic compounds catabolism
PF977_13940	COG1349	DNA-binding transcription factor activity
PF977_13945	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PF977_13950	COG1760	l-serine dehydratase
PF977_13955	COG1760	l-serine dehydratase
PF977_13960	COG1461	Dihydroxyacetone kinase
PF977_13965	COG1302	Protein conserved in bacteria
PF977_13970	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PF977_13980	COG1564	THIamine pyrophosphokinase
PF977_13985	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PF977_13990	COG1162	GTPase activity
PF977_13995	COG2815	serine threonine protein kinase
PF977_13995	COG0515	serine threonine protein kinase
PF977_14000	COG0631	protein serine/threonine phosphatase activity
PF977_14005	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PF977_14010	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
PF977_14010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
PF977_14015	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PF977_14020	COG0242	peptide deformylase activity
PF977_14025	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PF977_14030	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
PF977_14035	COG1758	RNA polymerase activity
PF977_14040	COG0194	GDP metabolic process
PF977_14050	COG1561	YicC-like family, N-terminal region
PF977_14055	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
PF977_14060	COG1293	RNA-binding protein homologous to eukaryotic snRNP
PF977_14065	COG1648	precorrin-2 dehydrogenase activity
PF977_14070	COG2138	Cobalamin (vitamin B12) biosynthesis CbiX protein
PF977_14075	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PF977_14080	COG0529	Catalyzes the synthesis of activated sulfate
PF977_14085	COG2046	Belongs to the sulfate adenylyltransferase family
PF977_14090	COG0306	phosphate transporter
PF977_14095	COG0175	sulfate reduction
PF977_14100	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PF977_14105	COG0284	orotidine-5'-phosphate decarboxylase activity
PF977_14110	COG0167	dihydroorotate dehydrogenase activity
PF977_14115	COG0543	2 iron, 2 sulfur cluster binding
PF977_14120	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PF977_14125	COG0505	Belongs to the CarA family
PF977_14130	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PF977_14135	COG0540	Belongs to the ATCase OTCase family
PF977_14140	COG2233	PERMEase
PF977_14145	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
PF977_14150	COG0564	pseudouridine synthase activity
PF977_14155	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PF977_14160	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PF977_14165	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
PF977_14170	COG3599	regulation of cell shape
PF977_14175	COG2302	S4 RNA-binding domain
PF977_14180	COG0762	integral membrane protein
PF977_14185	COG1799	cell septum assembly
PF977_14190	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PF977_14195	COG1496	oxidoreductase activity
PF977_14200	COG1873	PFAM PRC-barrel domain
PF977_14205	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PF977_14210	COG1119	ATPase activity
PF977_14215	COG1191	sigma factor activity
PF977_14220	COG1191	sigma factor activity
PF977_14230	COG4412	M6 family metalloprotease domain protein
PF977_14230	COG1404	Belongs to the peptidase S8 family
PF977_14235	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PF977_14240	COG0849	cell division
PF977_14245	COG3856	small basic protein
PF977_14250	COG3879	Bacterial protein of unknown function (DUF881)
PF977_14255	COG3879	Bacterial protein of unknown function (DUF881)
PF977_14260	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
PF977_14265	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PF977_14270	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PF977_14275	COG0772	Belongs to the SEDS family
PF977_14280	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PF977_14285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PF977_14290	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PF977_14295	COG0768	penicillin binding
PF977_14300	COG0768	penicillin binding
PF977_14305	COG4839	cell division protein FtsL
PF977_14310	COG0275	rRNA processing
PF977_14315	COG2001	Belongs to the MraZ family
PF977_14320	COG4365	Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH
PF977_14325	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PF977_14330	COG0454	-acetyltransferase
PF977_14345	COG1399	metal-binding, possibly nucleic acid-binding protein
PF977_14355	COG1323	Belongs to the UPF0348 family
PF977_14360	COG3480	Lon protease (S16) C-terminal proteolytic domain
PF977_14365	COG1752	Esterase of the alpha-beta hydrolase superfamily
PF977_14370	COG3314	Sporulation integral membrane protein YlbJ
PF977_14375	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PF977_14380	COG0742	ribosomal rna small subunit methyltransferase
PF977_14385	COG4471	UPF0298 protein
PF977_14390	COG3679	Belongs to the UPF0342 family
PF977_14405	COG2340	Cysteine-rich secretory protein family
PF977_14410	COG2905	signal-transduction protein containing cAMP-binding and CBS domains
PF977_14420	COG3336	cytochrome c oxidase
PF977_14425	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
PF977_14430	COG1845	cytochrome c oxidase, subunit III
PF977_14435	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
PF977_14440	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
PF977_14440	COG2010	Cytochrome c
PF977_14445	COG0109	protoheme IX farnesyltransferase activity
PF977_14450	COG1612	heme a metabolic process
PF977_14455	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
PF977_14460	COG0772	Belongs to the SEDS family
PF977_14465	COG4838	Belongs to the UPF0358 family
PF977_14470	COG2066	Belongs to the glutaminase family
PF977_14475	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PF977_14480	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
PF977_14490	COG4896	Protein conserved in bacteria
PF977_14500	COG1217	gtp-binding protein TYPA
PF977_14540	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
PF977_14550	COG0483	inositol monophosphate 1-phosphatase activity
PF977_14560	COG4493	Belongs to the UPF0637 family
PF977_14565	COG4476	Belongs to the UPF0223 family
PF977_14570	COG1982	Orn Lys Arg decarboxylase major
PF977_14580	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF977_14585	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF977_14590	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF977_14595	COG0022	dehydrogenase e1 component
PF977_14600	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PF977_14605	COG0497	DNA recombination
PF977_14615	COG0242	peptide deformylase activity
PF977_14620	COG0561	phosphatase activity
PF977_14625	COG5503	Protein of unknown function (DUF1447)
PF977_14630	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
PF977_14635	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
PF977_14640	COG0569	domain protein
PF977_14645	COG2105	PFAM AIG2 family protein
PF977_14645	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
PF977_14650	COG3852	Histidine kinase
PF977_14655	COG2002	toxin-antitoxin pair type II binding
PF977_14660	COG1077	Cell shape determining protein MreB Mrl
PF977_14670	COG2309	aminopeptidase activity
PF977_14675	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
PF977_14680	COG0488	(ABC) transporter
PF977_14690	COG0681	Belongs to the peptidase S26 family
PF977_14695	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF977_14695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF977_14695	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF977_14700	COG1105	Belongs to the carbohydrate kinase PfkB family
PF977_14705	COG1349	DNA-binding transcription factor activity
PF977_14710	COG0577	efflux transmembrane transporter activity
PF977_14715	COG1136	(ABC) transporter
PF977_14720	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PF977_14730	COG1132	(ABC) transporter
PF977_14735	COG1132	(ABC) transporter
PF977_14740	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
PF977_14745	COG0314	molybdopterin synthase activity
PF977_14750	COG1763	Mo-molybdopterin cofactor biosynthetic process
PF977_14755	COG0303	'Molybdopterin
PF977_14760	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PF977_14765	COG0746	molybdenum cofactor guanylyltransferase activity
PF977_14780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF977_14785	COG0450	alkyl hydroperoxide reductase
PF977_14790	COG0668	transmembrane transport
PF977_14800	COG1473	amidohydrolase
PF977_14805	COG2171	N-acyltransferase activity
PF977_14810	COG0716	FMN binding
PF977_14820	COG0716	FMN binding
PF977_14825	COG0583	DNA-binding transcription factor activity
PF977_14830	COG0517	IMP dehydrogenase activity
PF977_14840	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
PF977_14845	COG4703	Protein of unknown function (DUF1797)
PF977_14850	COG2200	EAL domain
PF977_14855	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_14860	COG1408	metallophosphoesterase
PF977_14865	COG1376	ErfK ybiS ycfS ynhG family protein
PF977_14870	COG2814	Major facilitator Superfamily
PF977_14880	COG0835	chemotaxis
PF977_14880	COG0784	Response regulator, receiver
PF977_14890	COG0436	Aminotransferase
PF977_14895	COG4191	Histidine kinase
PF977_14900	COG0768	penicillin binding
PF977_14905	COG2340	Cysteine-rich secretory protein family
PF977_14910	COG2084	Dehydrogenase
PF977_14915	COG0840	transmembrane signaling receptor activity
PF977_14920	COG0456	acetyltransferase
PF977_14925	COG1533	DNA photolyase activity
PF977_14935	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
PF977_14940	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF977_14945	COG1263	PTS System
PF977_14945	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF977_14945	COG2190	(PTS) system
PF977_14950	COG3711	transcriptional antiterminator
PF977_14955	COG1609	Transcriptional regulator
PF977_14960	COG0006	proline dipeptidase activity
PF977_14970	COG2217	Heavy metal translocating P-type atpase
PF977_14975	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF977_14980	COG2244	polysaccharide biosynthetic process
PF977_14985	COG3773	Cell wall hydrolase
PF977_14995	COG4873	Protein conserved in bacteria
PF977_15005	COG3858	chitin binding
PF977_15010	COG1388	LysM domain
PF977_15015	COG4641	Protein conserved in bacteria
PF977_15015	COG1388	LysM domain
PF977_15020	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_15025	COG1733	regulation of RNA biosynthetic process
PF977_15030	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PF977_15035	COG0602	queuosine metabolic process
PF977_15040	COG0720	synthase
PF977_15045	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PF977_15050	COG3949	Membrane
PF977_15055	COG0542	response to heat
PF977_15060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PF977_15065	COG1360	Flagellar Motor Protein
PF977_15070	COG1846	Transcriptional regulator
PF977_15075	COG3852	Histidine kinase
PF977_15090	COG3339	Conserved Protein
PF977_15095	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
PF977_15100	COG0235	Class ii aldolase
PF977_15105	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
PF977_15110	COG1850	ribulose-bisphosphate carboxylase activity
PF977_15115	COG0436	Aminotransferase
PF977_15120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PF977_15125	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
PF977_15130	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
PF977_15140	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PF977_15145	COG5002	protein histidine kinase activity
PF977_15150	COG3594	Acyltransferase
PF977_15165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PF977_15170	COG0501	Belongs to the peptidase M48B family
PF977_15190	COG1191	sigma factor activity
PF977_15195	COG0861	Integral membrane protein TerC family
PF977_15200	COG0586	Pfam SNARE associated Golgi protein
PF977_15205	COG3300	MHYT domain
PF977_15205	COG5001	Diguanylate cyclase
PF977_15210	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
PF977_15215	COG1793	dna ligase
PF977_15215	COG3285	dna ligase
PF977_15220	COG0463	Glycosyl transferase, family 2
PF977_15230	COG1408	metallophosphoesterase
PF977_15235	COG0726	polysaccharide deacetylase
PF977_15240	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
PF977_15245	COG1846	Transcriptional regulator
PF977_15260	COG0789	Transcriptional regulator
PF977_15265	COG2239	Acts as a magnesium transporter
PF977_15280	COG3212	peptidase
PF977_15285	COG3212	peptidase
PF977_15290	COG3850	Histidine kinase
PF977_15290	COG5002	protein histidine kinase activity
PF977_15295	COG0745	RESPONSE REGULATOR receiver
PF977_15305	COG4721	ABC-type cobalt transport system, permease component
PF977_15310	COG1122	ATPase activity
PF977_15315	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
PF977_15320	COG1366	Belongs to the anti-sigma-factor antagonist family
PF977_15325	COG1404	Belongs to the peptidase S8 family
PF977_15330	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
PF977_15335	COG0590	tRNA wobble adenosine to inosine editing
PF977_15345	COG1764	response to oxidative stress
PF977_15350	COG1846	Transcriptional regulator
PF977_15355	COG1764	response to oxidative stress
PF977_15360	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PF977_15365	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
PF977_15370	COG0788	formyltetrahydrofolate deformylase activity
PF977_15375	COG2076	Multidrug Resistance protein
PF977_15380	COG2076	Multidrug Resistance protein
PF977_15385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PF977_15390	COG2318	DinB family
PF977_15395	COG2323	membrane
PF977_15405	COG1017	nitric oxide dioxygenase activity
PF977_15405	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
PF977_15410	COG1607	acyl-coa hydrolase
PF977_15415	COG1834	amidinotransferase
PF977_15420	COG2706	6-phosphogluconolactonase activity
PF977_15425	COG4608	Belongs to the ABC transporter superfamily
PF977_15430	COG0791	NLP P60 protein
PF977_15435	COG4948	Mandelate Racemase Muconate Lactonizing
PF977_15440	COG1619	proteins homologs of microcin C7 resistance protein MccF
PF977_15445	COG4166	transmembrane transport
PF977_15450	COG0444	Belongs to the ABC transporter superfamily
PF977_15455	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PF977_15460	COG0601	transmembrane transport
PF977_15465	COG2362	D-Aminopeptidase
PF977_15470	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PF977_15475	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PF977_15485	COG0463	Glycosyl transferase, family 2
PF977_15490	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
PF977_15500	COG0346	lactoylglutathione lyase activity
PF977_15505	COG0531	amino acid
PF977_15510	COG1392	Phosphate transport regulator
PF977_15515	COG0306	phosphate transporter
PF977_15535	COG3409	Peptidoglycan-binding domain 1 protein
PF977_15535	COG5632	N-Acetylmuramoyl-L-alanine amidase
PF977_15575	COG3778	Protein conserved in bacteria
PF977_15580	COG3299	homolog of phage Mu protein gp47
PF977_15585	COG3628	GPW Gp25 family protein
PF977_15595	COG4193	domain, Protein
PF977_15600	COG1652	LysM domain
PF977_15605	COG3953	SLT domain
PF977_15605	COG5412	phage tail tape measure protein
PF977_15605	COG3953	SLT domain
PF977_15605	COG5412	phage tail tape measure protein
PF977_15655	COG4653	Phage capsid family
PF977_15660	COG0338	D12 class N6 adenine-specific DNA methyltransferase
PF977_15665	COG5518	Phage portal protein
PF977_15670	COG1783	phage Terminase large subunit
PF977_15675	COG3728	DNA packaging
PF977_15675	COG5484	DNA packaging
PF977_15680	COG1595	DNA-templated transcription, initiation
PF977_15700	COG1484	DNA-dependent DNA replication
PF977_15705	COG1522	sequence-specific DNA binding
PF977_15715	COG1396	sequence-specific DNA binding
PF977_15720	COG2856	Zn peptidase
PF977_15725	COG3546	catalase activity
PF977_15730	COG4195	phage-related replication protein
PF977_15740	COG1388	LysM domain
PF977_15740	COG3409	Peptidoglycan-binding domain 1 protein
PF977_15740	COG5632	N-Acetylmuramoyl-L-alanine amidase
PF977_15745	COG2350	Protein conserved in bacteria
PF977_15755	COG0457	Tetratricopeptide repeat
PF977_15760	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PF977_15765	COG2318	DinB family
PF977_15770	COG0730	response to heat
PF977_15775	COG2721	sulfolactate sulfo-lyase activity
PF977_15780	COG0246	Mannitol dehydrogenase
PF977_15785	COG1609	Transcriptional regulator
PF977_15790	COG2271	Major facilitator Superfamily
PF977_15795	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_15800	COG1312	Catalyzes the dehydration of D-mannonate
PF977_15805	COG1063	alcohol dehydrogenase
PF977_15810	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
PF977_15815	COG2211	Major facilitator Superfamily
PF977_15820	COG1904	glucuronate isomerase
PF977_15825	COG1252	NADH dehydrogenase
PF977_15835	COG4297	protein containing double-stranded beta helix domain
PF977_15840	COG0697	spore germination
PF977_15845	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
PF977_15850	COG0390	transport system, permease component
PF977_15855	COG1587	Uroporphyrinogen-III synthase
PF977_15865	COG1819	glycosyl
PF977_15870	COG2124	cytochrome p450
PF977_15880	COG1051	belongs to the nudix hydrolase family
PF977_15890	COG2427	Protein of unknown function (DUF1641)
PF977_15895	COG3383	formate dehydrogenase (NAD+) activity
PF977_15905	COG2205	protein histidine kinase activity
PF977_15910	COG5504	Zn-dependent protease
PF977_15925	COG0726	polysaccharide deacetylase
PF977_15935	COG0109	protoheme IX farnesyltransferase activity
PF977_15950	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
PF977_15960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PF977_15970	COG1482	cell wall glycoprotein biosynthetic process
PF977_15975	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF977_15975	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
PF977_15975	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF977_15980	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF977_15980	COG3711	transcriptional antiterminator
PF977_15990	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_15995	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
PF977_16045	COG5444	nuclease activity
PF977_16060	COG5505	Protein of unknown function (DUF819)
PF977_16065	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PF977_16070	COG0626	cystathionine gamma-synthase activity
PF977_16075	COG0626	cystathionine gamma-synthase activity
PF977_16080	COG2382	esterase
PF977_16085	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
PF977_16090	COG2153	protein acetylation
PF977_16100	COG0210	DNA helicase
PF977_16155	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PF977_16160	COG0351	phosphomethylpyrimidine kinase
PF977_16165	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
PF977_16170	COG2022	thiamine diphosphate biosynthetic process
PF977_16175	COG2104	thiamine diphosphate biosynthetic process
PF977_16180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF977_16185	COG0352	thiamine-phosphate diphosphorylase activity
PF977_16190	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PF977_16195	COG0569	domain protein
PF977_16195	COG0475	glutathione-regulated potassium exporter activity
PF977_16200	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
PF977_16205	COG0564	pseudouridine synthase activity
PF977_16210	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PF977_16215	COG2357	RelA SpoT domain protein
PF977_16225	COG4116	CYTH
PF977_16230	COG0741	lytic transglycosylase activity
PF977_16235	COG2346	COG2346, Truncated hemoglobins
PF977_16240	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
PF977_16250	COG1164	Oligoendopeptidase f
PF977_16255	COG4469	Competence protein
PF977_16265	COG4862	establishment of competence for transformation
PF977_16275	COG0861	Integral membrane protein TerC family
PF977_16280	COG1393	Belongs to the ArsC family
PF977_16285	COG0456	acetyltransferase
PF977_16290	COG2814	Major facilitator Superfamily
PF977_16295	COG4608	Belongs to the ABC transporter superfamily
PF977_16300	COG0444	Belongs to the ABC transporter superfamily
PF977_16305	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PF977_16310	COG0601	transmembrane transport
PF977_16315	COG4166	transmembrane transport
PF977_16320	COG0180	Tryptophanyl-tRNA synthetase
PF977_16330	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PF977_16335	COG0601	transmembrane transport
PF977_16345	COG4608	Belongs to the ABC transporter superfamily
PF977_16350	COG0444	Belongs to the ABC transporter superfamily
PF977_16355	COG5504	Zn-dependent protease
PF977_16360	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PF977_16365	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PF977_16380	COG1744	ABC transporter substrate-binding protein PnrA-like
PF977_16390	COG2267	carboxylic ester hydrolase activity
PF977_16405	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PF977_16410	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PF977_16415	COG0505	Belongs to the CarA family
PF977_16420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PF977_16430	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
PF977_16435	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PF977_16440	COG2271	Major facilitator Superfamily
PF977_16445	COG0277	FAD linked oxidase domain protein
PF977_16455	COG2151	metal-sulfur cluster biosynthetic enzyme
PF977_16460	COG1073	alpha beta
PF977_16465	COG0561	phosphatase activity
PF977_16485	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF977_16490	COG1307	EDD domain protein, DegV family
PF977_16495	COG3227	Zinc metalloprotease (Elastase)
PF977_16510	COG1695	Transcriptional regulator
PF977_16530	COG2996	Protein conserved in bacteria
PF977_16535	COG1666	GTP binding
PF977_16540	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PF977_16540	COG0646	methionine synthase
PF977_16545	COG2153	protein acetylation
PF977_16550	COG0454	-acetyltransferase
PF977_16555	COG2814	Major facilitator Superfamily
PF977_16560	COG4948	Mandelate Racemase Muconate Lactonizing
PF977_16565	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF977_16570	COG1809	phosphosulfolactate synthase activity
PF977_16575	COG2045	Belongs to the ComB family
PF977_16580	COG0175	sulfate reduction
PF977_16585	COG2046	Belongs to the sulfate adenylyltransferase family
PF977_16590	COG0529	Catalyzes the synthesis of activated sulfate
PF977_16595	COG2267	carboxylic ester hydrolase activity
PF977_16600	COG1357	PFAM Pentapeptide repeats (8 copies)
PF977_16605	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF977_16615	COG2318	DinB family
PF977_16620	COG0673	inositol 2-dehydrogenase activity
PF977_16625	COG1609	Transcriptional regulator
PF977_16630	COG1917	Cupin 2, conserved barrel domain protein
PF977_16630	COG2207	Transcriptional regulator
PF977_16635	COG0534	Mate efflux family protein
PF977_16640	COG1562	ergosterol biosynthetic process
PF977_16645	COG2318	DinB family
PF977_16650	COG0367	asparagine synthase
PF977_16660	COG1404	Belongs to the peptidase S8 family
PF977_16670	COG0179	Fumarylacetoacetate (FAA) hydrolase
PF977_16675	COG5337	Spore coat protein CotH
PF977_16715	COG1403	HNH endonuclease
PF977_16720	COG0419	ATPase involved in DNA repair
PF977_16725	COG0420	3'-5' exonuclease activity
PF977_16730	COG1074	ATP-dependent DNA helicase activity
PF977_16735	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
PF977_16740	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
PF977_16750	COG4533	DNA binding
PF977_16755	COG2814	Major facilitator Superfamily
PF977_16755	COG0477	Major facilitator Superfamily
PF977_16760	COG3180	Ammonia monooxygenase
PF977_16765	COG1609	Transcriptional regulator
PF977_16770	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PF977_16775	COG0561	phosphatase activity
PF977_16780	COG0673	inositol 2-dehydrogenase activity
PF977_16785	COG0738	Major facilitator superfamily
PF977_16790	COG1846	Transcriptional regulator
PF977_16795	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF977_16800	COG0681	Belongs to the peptidase S26 family
PF977_16805	COG0398	Pfam SNARE associated Golgi protein
PF977_16820	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF977_16830	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_16835	COG4903	ComK protein
PF977_16845	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_16850	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PF977_16850	COG0723	plastoquinol--plastocyanin reductase activity
PF977_16855	COG0840	transmembrane signaling receptor activity
PF977_16860	COG1268	BioY protein
PF977_16865	COG0318	PFAM AMP-dependent synthetase and ligase
PF977_16870	COG0183	Belongs to the thiolase family
PF977_16875	COG0406	alpha-ribazole phosphatase activity
PF977_16880	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
PF977_16885	COG0604	alcohol dehydrogenase
PF977_16890	COG0456	acetyltransferase
PF977_16895	COG1404	Belongs to the peptidase S8 family
PF977_16900	COG0501	Belongs to the peptidase M48B family
PF977_16910	COG0318	PFAM AMP-dependent synthetase and ligase
PF977_16915	COG0702	epimerase
PF977_16920	COG0095	Lipoate-protein ligase
PF977_16925	COG1234	tRNA 3'-trailer cleavage
PF977_16935	COG1301	dicarboxylic acid transport
PF977_16940	COG4405	Protein conserved in bacteria
PF977_16945	COG1363	Peptidase, m42
PF977_16955	COG4377	Putative membrane peptidase family (DUF2324)
PF977_16960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PF977_16965	COG1511	domain protein
PF977_16970	COG1309	transcriptional regulator
PF977_16975	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
PF977_16980	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PF977_16985	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PF977_16990	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
PF977_16995	COG2329	Antibiotic biosynthesis monooxygenase
PF977_17005	COG3069	C4-dicarboxylate transmembrane transporter activity
PF977_17010	COG1473	amidohydrolase
PF977_17020	COG4473	ABC transporter
PF977_17025	COG1131	(ABC) transporter
PF977_17030	COG0537	adenosine 5'-monophosphoramidase activity
PF977_17035	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PF977_17050	COG4980	gas vesicle protein
PF977_17055	COG1846	Transcriptional regulator
PF977_17085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PF977_17095	COG3481	metal-dependent phosphohydrolase, HD sub domain
PF977_17100	COG4717	serine-type aminopeptidase activity
PF977_17105	COG0420	3'-5' exonuclease activity
PF977_17110	COG1668	transmembrane transport
PF977_17115	COG4152	abc transporter atp-binding protein
PF977_17125	COG1024	Enoyl-CoA hydratase
PF977_17135	COG0490	domain, Protein
PF977_17140	COG0475	glutathione-regulated potassium exporter activity
PF977_17145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PF977_17150	COG0561	phosphatase activity
PF977_17155	COG4335	DNA alkylation repair
PF977_17160	COG3679	Belongs to the UPF0342 family
PF977_17165	COG4399	Belongs to the UPF0754 family
PF977_17170	COG0189	ligase activity
PF977_17175	COG0189	ligase activity
PF977_17195	COG0702	epimerase
PF977_17200	COG1132	(ABC) transporter
PF977_17205	COG1132	(ABC) transporter
PF977_17215	COG0589	response to stress
PF977_17220	COG1757	Na H antiporter
PF977_17225	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PF977_17230	COG0726	polysaccharide deacetylase
PF977_17235	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
PF977_17240	COG0668	transmembrane transport
PF977_17250	COG0584	glycerophosphoryl diester phosphodiesterase
PF977_17255	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PF977_17260	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PF977_17265	COG1253	flavin adenine dinucleotide binding
PF977_17270	COG0436	Aminotransferase
PF977_17275	COG0789	Transcriptional regulator
PF977_17280	COG1253	flavin adenine dinucleotide binding
PF977_17285	COG0204	Acyl-transferase
PF977_17290	COG0667	Aldo Keto reductase
PF977_17295	COG1595	DNA-templated transcription, initiation
PF977_17310	COG0456	acetyltransferase
PF977_17315	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF977_17320	COG0733	neurotransmitter:sodium symporter activity
PF977_17325	COG0531	amino acid
PF977_17330	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_17335	COG0372	Belongs to the citrate synthase family
PF977_17340	COG0583	DNA-binding transcription factor activity
PF977_17345	COG1388	LysM domain
PF977_17345	COG0791	NLP P60 protein
PF977_17350	COG1785	Belongs to the alkaline phosphatase family
PF977_17355	COG2719	SpoVR family
PF977_17360	COG0668	transmembrane transport
PF977_17365	COG1959	2 iron, 2 sulfur cluster binding
PF977_17370	COG0791	NLP P60 protein
PF977_17370	COG1388	LysM domain
PF977_17385	COG0431	NADPH-dependent FMN reductase
PF977_17390	COG2197	response regulator
PF977_17395	COG2203	Gaf domain
PF977_17395	COG4585	Histidine kinase
PF977_17400	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PF977_17405	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
PF977_17410	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
PF977_17415	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
PF977_17420	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
PF977_17425	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PF977_17430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
PF977_17430	COG3153	acetyltransferase
PF977_17435	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PF977_17440	COG0517	IMP dehydrogenase activity
PF977_17450	COG0564	pseudouridine synthase activity
PF977_17455	COG3764	Sortase (surface protein transpeptidase)
PF977_17460	COG4085	toxin activity
PF977_17460	COG1525	nuclease
PF977_17460	COG0737	Belongs to the 5'-nucleotidase family
PF977_17465	COG5577	PFAM Coat F domain
PF977_17485	COG1823	symporter activity
PF977_17490	COG3706	GGDEF domain
PF977_17495	COG1464	Belongs to the NlpA lipoprotein family
PF977_17500	COG1278	Cold shock
PF977_17505	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
PF977_17510	COG1131	(ABC) transporter
PF977_17515	COG1131	(ABC) transporter
PF977_17520	COG1725	Transcriptional regulator
PF977_17540	COG0655	NAD(P)H dehydrogenase (quinone) activity
PF977_17545	COG2814	Major facilitator Superfamily
PF977_17550	COG1566	PFAM secretion protein HlyD family protein
PF977_17555	COG1846	Transcriptional regulator
PF977_17560	COG2718	Belongs to the UPF0229 family
PF977_17565	COG2766	serine protein kinase
PF977_17570	COG1664	Polymer-forming cytoskeletal
PF977_17575	COG1664	Polymer-forming cytoskeletal
PF977_17580	COG0789	Transcriptional regulator
PF977_17585	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PF977_17595	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PF977_17600	COG3382	B3 4 domain protein
PF977_17610	COG1476	TRANSCRIPTIONal
PF977_17620	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PF977_17630	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF977_17635	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
PF977_17640	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
PF977_17645	COG1116	anion transmembrane transporter activity
PF977_17650	COG0753	catalase activity
PF977_17660	COG0277	FAD linked oxidase domain protein
PF977_17665	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PF977_17670	COG3340	Belongs to the peptidase S51 family
PF977_17675	COG5577	PFAM Coat F domain
PF977_17685	COG4326	sporulation control protein
PF977_17795	COG0735	belongs to the Fur family
PF977_17800	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PF977_17805	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
PF977_17810	COG4129	membrane
PF977_17815	COG1132	(ABC) transporter
PF977_17820	COG3557	Belongs to the UPF0374 family
PF977_17835	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_17845	COG1194	a g-specific adenine glycosylase
PF977_17850	COG1988	membrane-bound metal-dependent
PF977_17855	COG4485	Bacterial membrane protein, YfhO
PF977_17860	COG0463	Glycosyl transferase, family 2
PF977_17865	COG0596	Alpha beta hydrolase
PF977_17870	COG5658	integral membrane protein
PF977_17875	COG3103	Sh3 type 3 domain protein
PF977_17890	COG2814	Major facilitator Superfamily
PF977_17900	COG2137	regulation of response to DNA damage stimulus
PF977_17905	COG1090	epimerase
PF977_17920	COG0778	Nitroreductase
PF977_17925	COG0384	phenazine biosynthesis protein PhzF
PF977_17930	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF977_17935	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF977_17940	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PF977_17945	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
PF977_17945	COG0392	lysyltransferase activity
PF977_17950	COG1846	Transcriptional regulator
PF977_17955	COG2814	Major facilitator Superfamily
PF977_17960	COG2318	DinB family
PF977_17965	COG3936	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis biofilm formation
PF977_17970	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
PF977_17975	COG1695	Transcriptional regulator
PF977_17980	COG0842	Transport permease protein
PF977_17985	COG0842	Transport permease protein
PF977_17985	COG1511	domain protein
PF977_17990	COG1131	(ABC) transporter
PF977_17995	COG2197	response regulator
PF977_18000	COG4585	Histidine kinase
PF977_18005	COG2514	catechol 2,3-dioxygenase activity
PF977_18010	COG2259	Doxx family
PF977_18015	COG1132	(ABC) transporter
PF977_18020	COG1132	(ABC) transporter
PF977_18025	COG1263	PTS System
PF977_18025	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF977_18030	COG1737	Transcriptional regulator
PF977_18035	COG1486	melibiose metabolic process
PF977_18040	COG4842	Belongs to the WXG100 family
PF977_18060	COG1742	UPF0060 membrane protein
PF977_18070	COG3284	Transcriptional regulator
PF977_18075	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PF977_18080	COG0508	dehydrogenase complex catalyzes the overall conversion of
PF977_18085	COG0022	dehydrogenase e1 component
PF977_18090	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
PF977_18100	COG4637	Psort location Cytoplasmic, score
PF977_18105	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PF977_18115	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PF977_18120	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
PF977_18125	COG0598	Magnesium transport protein CorA
PF977_18130	COG2084	Dehydrogenase
PF977_18135	COG0726	polysaccharide deacetylase
PF977_18145	COG0535	radical SAM domain protein
PF977_18150	COG0668	transmembrane transport
PF977_18160	COG0387	Pfam Sodium calcium exchanger
PF977_18165	COG0477	Major facilitator Superfamily
PF977_18170	COG1295	ribonuclease BN
PF977_18175	COG4980	gas vesicle protein
PF977_18180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PF977_18185	COG4840	Belongs to the UPF0435 family
PF977_18190	COG2814	Major facilitator Superfamily
PF977_18195	COG0693	protein deglycase activity
PF977_18200	COG0737	Belongs to the 5'-nucleotidase family
PF977_18205	COG0778	Nitroreductase
PF977_18210	COG2188	Transcriptional regulator
PF977_18215	COG0366	Alpha amylase catalytic
PF977_18220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF977_18220	COG1263	PTS System
PF977_18225	COG0697	spore germination
PF977_18240	COG0531	amino acid
PF977_18245	COG1115	amino acid carrier protein
PF977_18260	COG1368	sulfuric ester hydrolase activity
PF977_18265	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF977_18265	COG1263	PTS System
PF977_18270	COG0024	Methionine aminopeptidase
PF977_18290	COG2258	MOSC domain
PF977_18295	COG1254	Belongs to the acylphosphatase family
PF977_18300	COG4362	Belongs to the NOS family. Bacterial NOS oxygenase subfamily
PF977_18305	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
PF977_18310	COG2851	Citrate transporter
PF977_18320	COG3181	Tripartite tricarboxylate transporter family receptor
PF977_18325	COG4565	transcriptional regulatory protein
PF977_18330	COG3290	protein histidine kinase activity
PF977_18335	COG0471	metal ion transport
PF977_18340	COG3866	Pectate lyase
PF977_18355	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
PF977_18360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF977_18365	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF977_18370	COG1120	ATPase activity
PF977_18375	COG1262	PFAM Formylglycine-generating sulfatase enzyme
PF977_18380	COG2211	Major facilitator Superfamily
PF977_18385	COG2130	NADP-dependent
PF977_18390	COG0456	acetyltransferase
PF977_18395	COG0513	Belongs to the DEAD box helicase family
PF977_18400	COG0488	(ABC) transporter
PF977_18410	COG2814	Major facilitator Superfamily
PF977_18415	COG0789	Transcriptional regulator
PF977_18425	COG0488	(ABC) transporter
PF977_18430	COG0840	transmembrane signaling receptor activity
PF977_18435	COG1012	belongs to the aldehyde dehydrogenase family
PF977_18440	COG0531	amino acid
PF977_18445	COG1011	Hydrolase
PF977_18450	COG2223	nitrite transmembrane transporter activity
PF977_18455	COG1442	glycosyl transferase family 8
PF977_18460	COG1216	Glycosyl transferase, family 2
PF977_18465	COG1442	glycosyl transferase family 8
PF977_18470	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PF977_18475	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PF977_18480	COG1368	sulfuric ester hydrolase activity
PF977_18485	COG2124	cytochrome p450
PF977_18485	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
PF977_18500	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
PF977_18505	COG1846	Transcriptional regulator
PF977_18510	COG0697	spore germination
PF977_18515	COG0670	Belongs to the BI1 family
PF977_18520	COG5583	Uncharacterized small protein (DUF2292)
PF977_18535	COG0346	lactoylglutathione lyase activity
PF977_18540	COG2329	Antibiotic biosynthesis monooxygenase
PF977_18545	COG2323	membrane
PF977_18550	COG1486	melibiose metabolic process
PF977_18555	COG0395	ABC-type sugar transport system, permease component
PF977_18560	COG4209	transmembrane transport
PF977_18565	COG1653	transport
PF977_18575	COG1874	Beta-galactosidase
PF977_18580	COG2755	lipolytic protein G-D-S-L family
PF977_18585	COG3401	FG-GAP repeat protein
PF977_18590	COG3401	FG-GAP repeat protein
PF977_18595	COG5578	integral membrane protein
PF977_18605	COG2755	lipolytic protein G-D-S-L family
PF977_18610	COG2207	Transcriptional regulator
PF977_18615	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
PF977_18620	COG0395	ABC-type sugar transport system, permease component
PF977_18625	COG1175	transmembrane transport
PF977_18630	COG1653	transport
PF977_18635	COG2207	Transcriptional regulator
PF977_18635	COG4753	response regulator
PF977_18640	COG2972	Histidine kinase
PF977_18645	COG5578	integral membrane protein
PF977_18655	COG0454	-acetyltransferase
PF977_18660	COG3546	catalase activity
PF977_18680	COG3631	Ketosteroid isomerase-related protein
PF977_18685	COG1309	transcriptional regulator
PF977_18695	COG0217	transcriptional regulatory protein
PF977_18705	COG0457	Tetratricopeptide repeat
PF977_18715	COG3391	amine dehydrogenase activity
PF977_18720	COG5444	nuclease activity
PF977_18735	COG0457	Tetratricopeptide repeat
PF977_18745	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PF977_18750	COG1597	lipid kinase activity
PF977_18755	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
PF977_18765	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PF977_18770	COG0154	amidase activity
PF977_18775	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PF977_18780	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF977_18785	COG1285	pathogenesis
PF977_18790	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
PF977_18795	COG4851	CamS sex pheromone cAM373 precursor
PF977_18800	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PF977_18805	COG0210	DNA helicase
PF977_18810	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
PF977_18815	COG0069	glutamate synthase activity
PF977_18820	COG4496	protein, YerC YecD
PF977_18825	COG1470	cell adhesion involved in biofilm formation
PF977_18830	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
PF977_18840	COG0531	amino acid
PF977_18845	COG1522	sequence-specific DNA binding
PF977_18850	COG0151	Belongs to the GarS family
PF977_18855	COG0138	bifunctional purine biosynthesis protein purh
PF977_18860	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PF977_18865	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PF977_18870	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PF977_18875	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PF977_18880	COG0047	phosphoribosylformylglycinamidine synthase activity
PF977_18885	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PF977_18890	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PF977_18895	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PF977_18900	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
PF977_18905	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PF977_18915	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
PF977_18925	COG3064	Membrane
PF977_18930	COG2252	PERMEase
PF977_18945	COG0519	Catalyzes the synthesis of GMP from XMP
PF977_18945	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PF977_18950	COG1305	Transglutaminase-like
PF977_18955	COG1721	protein (some members contain a von Willebrand factor type A (vWA) domain
PF977_18960	COG0714	Associated with various cellular activities
PF977_18965	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PF977_18975	COG1113	amino acid transport
PF977_18980	COG2132	Multicopper oxidase
PF977_18990	COG2267	carboxylic ester hydrolase activity
PF977_19005	COG0823	Involved in the tonB-independent uptake of proteins
PF977_19010	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PF977_19015	COG1063	alcohol dehydrogenase
PF977_19020	COG2814	Major facilitator Superfamily
PF977_19030	COG4260	virion core protein, lumpy skin disease virus
PF977_19035	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
PF977_19040	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PF977_19045	COG1842	Phage shock protein A
PF977_19050	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
PF977_19055	COG2211	Major facilitator Superfamily
PF977_19060	COG1063	alcohol dehydrogenase
PF977_19065	COG0457	Tetratricopeptide repeat
PF977_19070	COG1073	alpha beta
PF977_19115	COG3409	Peptidoglycan-binding domain 1 protein
PF977_19115	COG5632	N-Acetylmuramoyl-L-alanine amidase
PF977_19180	COG0791	NLP P60 protein
PF977_19180	COG1388	LysM domain
PF977_19185	COG5280	Phage tail tape measure protein TP901
PF977_19185	COG3953	SLT domain
PF977_19255	COG5484	DNA packaging
PF977_19280	COG1595	DNA-templated transcription, initiation
PF977_19350	COG1484	DNA-dependent DNA replication
PF977_19355	COG3935	DnaD domain protein
PF977_19405	COG1396	sequence-specific DNA binding
PF977_19415	COG2856	Zn peptidase
PF977_19420	COG4974	Belongs to the 'phage' integrase family
PF977_19425	COG0459	protein refolding
PF977_19435	COG1266	CAAX protease self-immunity
PF977_19445	COG0805	protein transport
PF977_19450	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PF977_19455	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
PF977_19460	COG0315	cyclic pyranopterin monophosphate synthase activity
PF977_19465	COG0488	(ABC) transporter
PF977_19470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PF977_19475	COG0456	acetyltransferase
PF977_19480	COG1214	PFAM Peptidase M22, glycoprotease
PF977_19485	COG0802	atpase or kinase
PF977_19490	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PF977_19535	COG4124	Belongs to the glycosyl hydrolase 26 family
PF977_19540	COG1482	cell wall glycoprotein biosynthetic process
PF977_19545	COG1940	carbohydrate kinase activity
PF977_19550	COG2188	Transcriptional regulator
PF977_19555	COG2723	6-phospho-beta-galactosidase activity
PF977_19560	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PF977_19565	COG1447	Phosphotransferase system cellobiose-specific component IIA
PF977_19570	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
PF977_19575	COG2814	Major facilitator Superfamily
PF977_19580	COG1388	LysM domain
PF977_19585	COG1078	dGTPase activity
PF977_19590	COG0454	-acetyltransferase
PF977_19600	COG5646	InterPro IPR014922
PF977_19605	COG1785	Belongs to the alkaline phosphatase family
PF977_19615	COG1819	glycosyl
PF977_19620	COG3858	chitin binding
PF977_19620	COG1388	LysM domain
PF977_19625	COG1802	Transcriptional regulator
PF977_19630	COG0730	response to heat
PF977_19635	COG2814	Major facilitator Superfamily
PF977_19640	COG1846	Transcriptional regulator
PF977_19645	COG0778	Nitroreductase
PF977_19650	COG2409	Drug exporters of the RND superfamily
PF977_19650	COG1033	growth of symbiont in host cell
PF977_19655	COG1846	Transcriptional regulator
PF977_19660	COG2318	DinB family
PF977_19665	COG1113	amino acid transport
PF977_19670	COG0488	(ABC) transporter
PF977_19675	COG0456	acetyltransferase
PF977_19685	COG1309	transcriptional regulator
PF977_19700	COG0071	Belongs to the small heat shock protein (HSP20) family
PF977_19705	COG2323	membrane
PF977_19710	COG2323	membrane
PF977_19730	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF977_19735	COG2259	Doxx family
PF977_19740	COG0346	lactoylglutathione lyase activity
PF977_19745	COG0778	Nitroreductase
PF977_19750	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PF977_19755	COG0789	Transcriptional regulator
PF977_19755	COG4978	Transcriptional regulator
PF977_19760	COG1811	Na channel or pump
PF977_19765	COG0596	Alpha beta hydrolase
PF977_19770	COG2409	Drug exporters of the RND superfamily
PF977_19775	COG2197	response regulator
PF977_19780	COG4585	Histidine kinase
PF977_19795	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
PF977_19800	COG0640	Transcriptional regulator
PF977_19805	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
PF977_19810	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF977_19815	COG0697	spore germination
PF977_19820	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PF977_19830	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
PF977_19835	COG0640	Transcriptional regulator
PF977_19845	COG1309	transcriptional regulator
PF977_19850	COG2814	Major facilitator Superfamily
PF977_19855	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
PF977_19860	COG1733	regulation of RNA biosynthetic process
PF977_19865	COG3545	Serine hydrolase
PF977_19870	COG2030	dehydratase
PF977_19875	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF977_19880	COG0697	spore germination
PF977_19885	COG1309	transcriptional regulator
PF977_19890	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF977_19900	COG4430	Bacteriocin-protection, YdeI or OmpD-Associated
PF977_19910	COG0477	Major facilitator Superfamily
PF977_19915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF977_19920	COG2207	Transcriptional regulator
PF977_19920	COG3708	Transcriptional regulator
PF977_19925	COG0697	spore germination
PF977_19930	COG1917	Cupin 2, conserved barrel domain protein
PF977_19930	COG2207	Transcriptional regulator
PF977_19935	COG0697	spore germination
PF977_19940	COG0457	Tetratricopeptide repeat
PF977_19945	COG1329	Transcriptional regulator
PF977_19950	COG1278	Cold shock
PF977_19955	COG0693	protein deglycase activity
PF977_19980	COG1476	TRANSCRIPTIONal
PF977_20030	COG3091	SprT-like family
PF977_20040	COG2183	response to ionizing radiation
PF977_20045	COG2208	phosphoserine phosphatase activity
PF977_20050	COG1191	sigma factor activity
PF977_20055	COG2172	sigma factor antagonist activity
PF977_20060	COG1366	Belongs to the anti-sigma-factor antagonist family
PF977_20065	COG2208	phosphoserine phosphatase activity
PF977_20070	COG2172	sigma factor antagonist activity
PF977_20075	COG1366	Belongs to the anti-sigma-factor antagonist family
PF977_20080	COG1366	Belongs to the anti-sigma-factor antagonist family
PF977_20085	COG2337	Toxic component of a toxin-antitoxin (TA) module
PF977_20090	COG0864	Transcriptional regulator
PF977_20095	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PF977_20100	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PF977_20105	COG0736	holo-[acyl-carrier-protein] synthase activity
PF977_20110	COG0705	Rhomboid family
PF977_20115	COG3428	Bacterial PH domain
PF977_20120	COG3402	PFAM membrane-flanked domain
PF977_20125	COG0513	Belongs to the DEAD box helicase family
PF977_20130	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
PF977_20135	COG1181	Belongs to the D-alanine--D-alanine ligase family
PF977_20140	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
PF977_20145	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PF977_20160	COG1960	acyl-CoA dehydrogenase activity
PF977_20170	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
PF977_20175	COG1131	(ABC) transporter
PF977_20180	COG0628	permease
PF977_20185	COG1301	dicarboxylic acid transport
PF977_20190	COG4565	transcriptional regulatory protein
PF977_20195	COG3290	protein histidine kinase activity
PF977_20200	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
PF977_20205	COG3546	catalase activity
PF977_20210	COG2329	Antibiotic biosynthesis monooxygenase
PF977_20215	COG0662	Cupin 2, conserved barrel domain protein
PF977_20220	COG3729	General stress protein
PF977_20225	COG2217	Heavy metal translocating P-type atpase
PF977_20230	COG4876	unkown
PF977_20235	COG2261	transglycosylase associated protein
PF977_20240	COG1914	H( )-stimulated, divalent metal cation uptake system
PF977_20255	COG0028	Belongs to the TPP enzyme family
PF977_20260	COG0494	nUDIX hydrolase
PF977_20265	COG0531	amino acid
PF977_20275	COG1215	transferase activity, transferring glycosyl groups
PF977_20285	COG3706	GGDEF domain
PF977_20290	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
PF977_20295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PF977_20295	COG0551	DNA topoisomerase type I activity
PF977_20300	COG1522	sequence-specific DNA binding
PF977_20305	COG2814	Major facilitator Superfamily
PF977_20315	COG3871	stress protein (general stress protein 26)
PF977_20320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PF977_20325	COG1917	Cupin 2, conserved barrel domain protein
PF977_20330	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_20335	COG2226	methyltransferase
PF977_20340	COG0318	PFAM AMP-dependent synthetase and ligase
PF977_20345	COG3711	transcriptional antiterminator
PF977_20350	COG4989	oxidoreductase activity
PF977_20355	COG0768	penicillin binding
PF977_20360	COG2329	Antibiotic biosynthesis monooxygenase
PF977_20370	COG2755	lipolytic protein G-D-S-L family
PF977_20375	COG1414	Transcriptional regulator
PF977_20380	COG1984	allophanate hydrolase subunit 2
PF977_20385	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
PF977_20390	COG4336	lyase activity
PF977_20395	COG1914	H( )-stimulated, divalent metal cation uptake system
PF977_20400	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
PF977_20405	COG0561	phosphatase activity
PF977_20415	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PF977_20420	COG0412	Dienelactone hydrolase
PF977_20425	COG0681	Belongs to the peptidase S26 family
PF977_20430	COG0473	3-isopropylmalate dehydrogenase activity
PF977_20435	COG0246	Mannitol dehydrogenase
PF977_20440	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
PF977_20445	COG2213	PTS system mannitol-specific
PF977_20455	COG1349	DNA-binding transcription factor activity
PF977_20460	COG1276	copper resistance
PF977_20460	COG2372	response to copper ion
PF977_20465	COG4549	nuclear export factor GLE1
PF977_20470	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_20475	COG4975	Glucose uptake
PF977_20480	COG1012	belongs to the aldehyde dehydrogenase family
PF977_20485	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
PF977_20490	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF977_20495	COG0640	Transcriptional regulator
PF977_20500	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
PF977_20505	COG0778	Nitroreductase
PF977_20510	COG1309	transcriptional regulator
PF977_20515	COG2814	Major facilitator Superfamily
PF977_20520	COG4607	ABC-type enterochelin transport system periplasmic component
PF977_20525	COG4604	ABC transporter, ATP-binding protein
PF977_20530	COG4605	iron ion homeostasis
PF977_20535	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF977_20540	COG0527	aspartate kinase activity
PF977_20560	COG0457	Tetratricopeptide repeat
PF977_20565	COG3850	Histidine kinase
PF977_20565	COG5002	protein histidine kinase activity
PF977_20570	COG0745	RESPONSE REGULATOR receiver
PF977_20575	COG0577	efflux transmembrane transporter activity
PF977_20580	COG1136	(ABC) transporter
PF977_20585	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
PF977_20595	COG0697	spore germination
PF977_20605	COG5434	Belongs to the glycosyl hydrolase 28 family
PF977_20610	COG3104	oligopeptide transport
PF977_20615	COG0596	Alpha beta hydrolase
PF977_20630	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PF977_20635	COG0163	prenyltransferase activity
PF977_20640	COG0583	DNA-binding transcription factor activity
PF977_20645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF977_20650	COG0765	amino acid transport
PF977_20655	COG1126	abc transporter atp-binding protein
PF977_20660	COG2364	Membrane
PF977_20670	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
PF977_20675	COG0697	spore germination
PF977_20685	COG2814	Major facilitator Superfamily
PF977_20690	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
PF977_20695	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_20700	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_20720	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
PF977_20725	COG1733	regulation of RNA biosynthetic process
PF977_20730	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
PF977_20735	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PF977_20740	COG3290	protein histidine kinase activity
PF977_20740	COG0840	transmembrane signaling receptor activity
PF977_20745	COG3209	COG3209 Rhs family protein
PF977_20755	COG2723	6-phospho-beta-galactosidase activity
PF977_20775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PF977_20780	COG0765	amino acid transport
PF977_20785	COG0523	cobalamin synthesis protein
PF977_20795	COG1376	ErfK ybiS ycfS ynhG family protein
PF977_20800	COG1469	GTP cyclohydrolase I activity
PF977_20805	COG2223	nitrite transmembrane transporter activity
PF977_20810	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF977_20815	COG0243	molybdopterin cofactor binding
PF977_20820	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
PF977_20825	COG2146	nitrite reductase [NAD(P)H] activity
PF977_20830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
PF977_20830	COG1587	Uroporphyrinogen-III synthase
PF977_20835	COG0492	ferredoxin-NADP+ reductase activity
PF977_20840	COG2267	carboxylic ester hydrolase activity
PF977_20845	COG0701	Predicted permease
PF977_20850	COG3689	TIGRFAM TIGR03943 family protein
PF977_20855	COG2508	Transcriptional regulator
PF977_20860	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PF977_20865	COG1012	belongs to the aldehyde dehydrogenase family
PF977_20870	COG0506	proline dehydrogenase activity
PF977_20875	COG3541	Predicted nucleotidyltransferase
PF977_20880	COG3458	cephalosporin-C deacetylase activity
PF977_20890	COG2226	methyltransferase
PF977_20895	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
PF977_20900	COG1660	Displays ATPase and GTPase activities
PF977_20905	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PF977_20910	COG3665	Urea carboxylase-associated protein
PF977_20915	COG1113	amino acid transport
PF977_20920	COG3403	YqcI/YcgG family
PF977_20925	COG1280	lysine exporter protein (LysE YggA)
PF977_20930	COG1846	Transcriptional regulator
PF977_20935	COG2814	Major facilitator Superfamily
PF977_20940	COG1620	l-lactate permease
PF977_20945	COG0039	L-malate dehydrogenase activity
PF977_20950	COG0366	Alpha amylase catalytic
PF977_20960	COG1288	antiporter activity
PF977_20965	COG1473	amidohydrolase
PF977_20970	COG2113	Glycine betaine
PF977_20975	COG4176	ABC-type proline glycine betaine transport system permease component
PF977_20980	COG4175	Glycine betaine
PF977_20980	COG0517	IMP dehydrogenase activity
PF977_20985	COG0640	Transcriptional regulator
PF977_20995	COG0477	Major facilitator Superfamily
PF977_21000	COG3853	Toxic anion resistance protein (TelA)
PF977_21010	COG0861	Integral membrane protein TerC family
PF977_21015	COG2310	stress, protein
PF977_21020	COG2310	stress, protein
PF977_21025	COG2310	stress, protein
PF977_21030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
PF977_21035	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PF977_21040	COG1121	(ABC) transporter
PF977_21045	COG0803	Belongs to the bacterial solute-binding protein 9 family
PF977_21050	COG0366	Alpha amylase catalytic
PF977_21055	COG1028	Short-chain dehydrogenase reductase Sdr
PF977_21060	COG0457	Tetratricopeptide repeat
PF977_21065	COG1876	peptidase activity
PF977_21070	COG1595	DNA-templated transcription, initiation
PF977_21075	COG1595	DNA-templated transcription, initiation
PF977_21090	COG0667	Aldo Keto reductase
PF977_21095	COG1668	transmembrane transport
PF977_21100	COG4555	ABC transporter
PF977_21105	COG3279	Response regulator of the LytR AlgR family
PF977_21110	COG3290	protein histidine kinase activity
PF977_21115	COG3012	SEC-C Motif Domain Protein
PF977_21115	COG1405	negative regulation of cell septum assembly
PF977_21120	COG1714	RDD family
PF977_21125	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
PF977_21130	COG0252	asparaginase activity
PF977_21135	COG1309	transcriptional regulator
PF977_21140	COG0477	Major facilitator Superfamily
PF977_21150	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
PF977_21155	COG0805	protein transport
PF977_21160	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PF977_21165	COG3540	Alkaline phosphatase
PF977_21175	COG2304	oxidoreductase activity
PF977_21180	COG3773	Cell wall hydrolase
PF977_21200	COG1131	(ABC) transporter
PF977_21205	COG2205	protein histidine kinase activity
PF977_21210	COG0745	RESPONSE REGULATOR receiver
PF977_21215	COG0697	spore germination
PF977_21225	COG3173	Aminoglycoside phosphotransferase
PF977_21230	COG2721	sulfolactate sulfo-lyase activity
PF977_21235	COG2186	Transcriptional regulator
PF977_21240	COG4948	Mandelate Racemase Muconate Lactonizing
PF977_21245	COG2271	Major facilitator Superfamily
PF977_21250	COG1012	belongs to the aldehyde dehydrogenase family
PF977_21255	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PF977_21260	COG0784	Response regulator, receiver
PF977_21265	COG4191	Histidine kinase
PF977_21270	COG2066	Belongs to the glutaminase family
PF977_21275	COG1115	amino acid carrier protein
PF977_21280	COG2040	homocysteine
PF977_21285	COG0833	amino acid
PF977_21290	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PF977_21300	COG2188	Transcriptional regulator
PF977_21305	COG0363	glucosamine-6-phosphate deaminase activity
PF977_21310	COG1263	PTS System
PF977_21310	COG2190	(PTS) system
PF977_21310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF977_21315	COG1301	dicarboxylic acid transport
PF977_21320	COG1054	Belongs to the UPF0176 family
PF977_21325	COG2312	Erythromycin esterase
PF977_21335	COG0688	phosphatidylethanolamine metabolic process
PF977_21340	COG0586	Pfam SNARE associated Golgi protein
PF977_21345	COG1183	phosphatidylcholine synthase activity
PF977_21350	COG0596	Alpha beta hydrolase
PF977_21360	COG3591	Belongs to the peptidase S1B family
PF977_21365	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
PF977_21370	COG1917	Cupin 2, conserved barrel domain protein
PF977_21370	COG2207	Transcriptional regulator
PF977_21375	COG0697	spore germination
PF977_21380	COG2271	Major facilitator Superfamily
PF977_21385	COG1846	Transcriptional regulator
PF977_21385	COG0456	acetyltransferase
PF977_21395	COG2271	Major facilitator Superfamily
PF977_21400	COG0584	glycerophosphoryl diester phosphodiesterase
PF977_21410	COG0531	amino acid
PF977_21420	COG2124	cytochrome p450
PF977_21425	COG2602	Beta-lactamase
PF977_21440	COG1113	amino acid transport
PF977_21455	COG0515	serine threonine protein kinase
PF977_21465	COG0642	Histidine kinase
PF977_21470	COG0745	RESPONSE REGULATOR receiver
PF977_21475	COG0596	Alpha beta hydrolase
PF977_21480	COG1132	(ABC) transporter
PF977_21500	COG1404	Belongs to the peptidase S8 family
PF977_21515	COG2814	Major facilitator Superfamily
PF977_21520	COG0640	Transcriptional regulator
PF977_21525	COG5609	conserved protein (DUF2294)
PF977_21535	COG0288	reversible hydration of carbon dioxide
PF977_21540	COG3002	Belongs to the UPF0753 family
PF977_21545	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PF977_21550	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PF977_21555	COG2169	Transcriptional regulator
PF977_21560	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
PF977_21570	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PF977_21575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PF977_21580	COG4856	YbbR-like protein
PF977_21585	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
PF977_21590	COG5662	AntiSigma factor
PF977_21595	COG1595	DNA-templated transcription, initiation
PF977_21630	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PF977_21635	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
PF977_21640	COG1737	Transcriptional regulator
PF977_21645	COG1263	PTS System
PF977_21645	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
PF977_21650	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
PF977_21655	COG1472	Belongs to the glycosyl hydrolase 3 family
PF977_21660	COG3876	Protein conserved in bacteria
PF977_21665	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PF977_21665	COG2207	Transcriptional regulator
PF977_21670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PF977_21675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF977_21680	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PF977_21685	COG2819	hydrolase of the alpha beta superfamily
PF977_21690	COG0385	Bile acid
PF977_21695	COG0659	secondary active sulfate transmembrane transporter activity
PF977_21780	COG0726	polysaccharide deacetylase
PF977_21785	COG2194	sulfuric ester hydrolase activity
PF977_21795	COG0489	protein tyrosine kinase activity
PF977_21800	COG0860	N-Acetylmuramoyl-L-alanine amidase
PF977_21810	COG2226	methyltransferase
PF977_21815	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PF977_21820	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PF977_21825	COG0101	tRNA pseudouridine synthase activity
PF977_21830	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
PF977_21835	COG1122	ATPase activity
PF977_21840	COG1122	ATPase activity
PF977_21845	COG0203	ribosomal protein L17
PF977_21850	COG0202	RNA polymerase activity
PF977_21855	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PF977_21860	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
PF977_21865	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PF977_21875	COG2163	COG2163 Ribosomal protein L14E L6E L27E
PF977_21880	COG0024	Methionine aminopeptidase
PF977_21885	COG0563	adenylate kinase activity
PF977_21890	COG0201	protein transport
PF977_21895	COG0200	Binds to the 23S rRNA
PF977_21905	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PF977_21910	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PF977_21915	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PF977_21920	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PF977_21930	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PF977_21940	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PF977_21945	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PF977_21955	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PF977_21960	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PF977_21975	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
PF977_21985	COG0088	Forms part of the polypeptide exit tunnel
PF977_21990	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PF977_22000	COG0596	Alpha beta hydrolase
PF977_22005	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PF977_22010	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
PF977_22015	COG0049	tRNA binding
PF977_22020	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PF977_22025	COG1358	cellular component organization or biogenesis
PF977_22030	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PF977_22035	COG0085	RNA polymerase activity
PF977_22040	COG2813	Specifically methylates the guanine in position
PF977_22050	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PF977_22055	COG0081	regulation of translation
PF977_22065	COG0250	Participates in transcription elongation, termination and antitermination
PF977_22070	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PF977_22080	COG1595	DNA-templated transcription, initiation
PF977_22085	COG3688	RNA-binding protein containing a PIN domain
PF977_22090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PF977_22095	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
PF977_22100	COG0215	cysteine-tRNA ligase activity
PF977_22105	COG1045	serine acetyltransferase
PF977_22110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PF977_22115	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PF977_22120	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PF977_22125	COG4956	integral membrane protein (PIN domain superfamily)
PF977_22130	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
PF977_22135	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
PF977_22140	COG0542	response to heat
PF977_22145	COG3869	Catalyzes the specific phosphorylation of arginine residues in
PF977_22150	COG3880	PFAM UvrB UvrC protein
PF977_22155	COG4463	regulation of RNA biosynthetic process
PF977_22235	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PF977_22240	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PF977_22245	COG1396	sequence-specific DNA binding
PF977_22250	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PF977_22255	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
PF977_22260	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PF977_22265	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
PF977_22270	COG0512	Glutamine amidotransferase of anthranilate synthase
PF977_22275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PF977_22280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PF977_22285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PF977_22290	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
PF977_22295	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PF977_22300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PF977_22305	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
PF977_22310	COG0037	tRNA processing
PF977_22315	COG0515	serine threonine protein kinase
PF977_22320	COG2304	oxidoreductase activity
PF977_22325	COG2208	phosphoserine phosphatase activity
PF977_22340	COG1098	S1 RNA binding domain
PF977_22345	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
PF977_22360	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PF977_22365	COG3956	TIGRFAM MazG family protein
PF977_22370	COG2244	polysaccharide biosynthetic process
PF977_22375	COG2002	toxin-antitoxin pair type II binding
PF977_22380	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PF977_22390	COG0193	aminoacyl-tRNA hydrolase activity
PF977_22395	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
PF977_22400	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PF977_22405	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PF977_22410	COG2088	sporulation resulting in formation of a cellular spore
PF977_22415	COG0251	oxidation-reduction process
PF977_22420	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PF977_22425	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
PF977_22435	COG4466	Protein conserved in bacteria
PF977_22445	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
PF977_22450	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
PF977_22455	COG3583	domain protein
PF977_22455	COG3584	3D domain protein
PF977_22460	COG0084	hydrolase, TatD family'
PF977_22465	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF977_22465	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PF977_22470	COG2002	toxin-antitoxin pair type II binding
PF977_22475	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PF977_22480	COG2827	Endonuclease containing a URI domain
PF977_22485	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
PF977_22490	COG4467	Involved in initiation control of chromosome replication
PF977_22495	COG1774	PSP1 C-terminal conserved region
PF977_22500	COG0470	DNA polymerase III
PF977_22505	COG1728	Protein conserved in bacteria
PF977_22510	COG3870	Protein conserved in bacteria
PF977_22515	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
PF977_22520	COG1982	Orn Lys Arg decarboxylase major
PF977_22525	COG3853	Toxic anion resistance protein (TelA)
PF977_22530	COG4915	5-bromo-4-chloroindolyl phosphate hydrolysis protein
PF977_22575	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PF977_22580	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PF977_22585	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PF977_22595	COG0590	tRNA wobble adenosine to inosine editing
PF977_22600	COG1335	isochorismatase
PF977_22605	COG1388	LysM domain
PF977_22605	COG3858	chitin binding
PF977_22610	COG1428	Deoxynucleoside kinase
PF977_22615	COG1428	Deoxynucleoside kinase
PF977_22625	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PF977_22630	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
PF977_22635	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
PF977_22640	COG1686	Belongs to the peptidase S11 family
PF977_22645	COG0516	GMP reductase activity
PF977_22645	COG0517	IMP dehydrogenase activity
PF977_22680	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PF977_22685	COG0187	DNA topoisomerase II activity
PF977_22695	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
PF977_22700	COG2501	S4 domain
PF977_22705	COG0592	DNA-directed DNA polymerase activity