locus-tag class description G4G26_00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) G4G26_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) G4G26_00015 ENOG410848D S4 domain protein YaaA G4G26_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G4G26_00035 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G4G26_00070 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G4G26_00080 ENOG4105CD9 Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity) G4G26_00085 ENOG4108UHX Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity) G4G26_00090 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) G4G26_00100 ENOG4105ZMH deoxynucleoside kinase G4G26_00110 ENOG4105VRS hydrolase family 18 G4G26_00115 ENOG4105GTG Isochorismatase G4G26_00120 ENOG4108Z6B deaminase G4G26_00130 ENOG4105C6E dna polymerase iii G4G26_00135 ENOG410816I Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) G4G26_00140 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) G4G26_00150 ENOG41067KS pro-sigma K processing G4G26_00190 ENOG4105CDW Resistance protein G4G26_00195 ENOG4105CXN decarboxylase G4G26_00200 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) G4G26_00205 ENOG4105X0R protein from nitrogen regulatory protein P-II G4G26_00210 ENOG4105XVJ Protein of unknown function (DUF327) G4G26_00215 ENOG4105FA2 dna polymerase iii G4G26_00220 ENOG4105MA4 psp1 domain protein G4G26_00225 ENOG4105QD5 Involved in initiation control of chromosome replication (By similarity) G4G26_00230 ENOG41060K3 Methyltransferase G4G26_00235 ENOG4105VC4 domain protein G4G26_00240 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) G4G26_00245 ENOG4105KRN Transcriptional regulator, abrb family G4G26_00250 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) G4G26_00255 ENOG4105F8V Hydrolase, tatD family G4G26_00260 ENOG41069ER domain protein G4G26_00270 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) G4G26_00275 ENOG4105XFA sporulation peptidase YabG G4G26_00280 ENOG4105W42 Veg protein G4G26_00285 ENOG4105XEW small acid-soluble spore protein G4G26_00290 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) G4G26_00295 ENOG4105DFT pur operon repressor G4G26_00300 ENOG4105KME endoribonuclease L-psp G4G26_00305 ENOG4105K4W Could be involved in septation (By similarity) G4G26_00310 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) G4G26_00315 ENOG4105C5T Phosphoribosyl pyrophosphate synthase G4G26_00320 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) G4G26_00325 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) G4G26_00335 ENOG4108JA2 transcriptioN-repair coupling factor G4G26_00340 ENOG4108M14 stage v sporulation protein t G4G26_00350 ENOG4108IY2 MazG family G4G26_00355 ENOG41082I2 s4 domain protein G4G26_00360 ENOG4105VYY sporulation protein yabp G4G26_00375 ENOG41060GV RNA binding s1 domain protein G4G26_00405 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) G4G26_00410 ENOG4108UGV hypoxanthine phosphoribosyltransferase G4G26_00415 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G4G26_00425 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) G4G26_00430 ENOG4107U48 ppic-type peptidyL-prolyl cis-trans isomerase G4G26_00435 ENOG4105C6T cysteine synthase G4G26_00440 ENOG4105CRQ synthase (Component I) G4G26_00445 ENOG4105DDQ anthranilate synthase G4G26_00450 ENOG41082R7 4-amino-4-deoxychorismate lyase EC 4.1.3.38 G4G26_00455 ENOG4105EEI dihydropteroate synthase G4G26_00460 ENOG4105KRF dihydroneopterin aldolase G4G26_00465 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase G4G26_00475 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) G4G26_00480 ENOG4105CRK lysyL-tRNA synthetase G4G26_00565 ENOG4108Z0C Uvrb UvrC protein G4G26_00570 ENOG41066A3 ATP guanido phosphotransferase G4G26_00580 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) G4G26_00585 ENOG4105E59 Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity) G4G26_00590 ENOG4105CTP PilT protein domain protein G4G26_00595 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) G4G26_00600 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) G4G26_00605 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) G4G26_00610 ENOG4105D7W serine acetyltransferase G4G26_00615 ENOG4105C8N cysteinyl-tRNA synthetase G4G26_00620 ENOG4105KEB Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc) G4G26_00625 ENOG4105C2N RNA methyltransferase TrmH family group 3 G4G26_00630 ENOG4105M0M Tetracycline resistance protein G4G26_00650 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) G4G26_00665 ENOG4108VZM 50s ribosomal protein L10 G4G26_00675 ENOG4107Y49 methyltransferase G4G26_00680 ENOG4108IIJ DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G4G26_00685 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G4G26_00690 ENOG4105XPM ribosomal protein G4G26_00695 ENOG4108UKE Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity) G4G26_00700 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) G4G26_00705 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) G4G26_00710 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) G4G26_00715 ENOG4107SKW Inherit from COG: Alpha beta hydrolase G4G26_00720 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) G4G26_00725 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) G4G26_00730 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) G4G26_00740 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity G4G26_00755 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) G4G26_00760 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) G4G26_00770 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal G4G26_00775 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) G4G26_00785 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits G4G26_00795 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) G4G26_00800 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) G4G26_00805 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) G4G26_00810 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) G4G26_00820 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) G4G26_00825 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) G4G26_00835 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) G4G26_00850 ENOG41067V7 50S ribosomal protein L36 G4G26_00855 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits G4G26_00860 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) G4G26_00865 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) G4G26_00870 ENOG4108ZT0 50S ribosomal protein l17 G4G26_00875 ENOG4108JJB ABC transporter G4G26_00880 ENOG4108JJB ABC transporter G4G26_00885 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) G4G26_00890 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) G4G26_00895 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) G4G26_00900 ENOG4108UJD 30S ribosomal protein S9 G4G26_00905 ENOG4108I0C methyltransferase G4G26_00920 ENOG4105D1F ATP-binding protein G4G26_00935 ENOG4108NMV polysaccharide deacetylase G4G26_01020 ENOG4105CHH sulfate transporter G4G26_01030 ENOG4108SA1 esterase G4G26_01050 ENOG410874W AraC family transcriptional regulator G4G26_01055 ENOG4105EHZ conserved protein UCP016719 G4G26_01060 ENOG4105D17 glycoside hydrolase, family 3 domain protein G4G26_01080 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate G4G26_01120 ENOG4105EMN RNA polymerase sigma factor G4G26_01130 ENOG4105C8B TIGR00159 family G4G26_01135 ENOG4107U5W ybbr family G4G26_01140 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) G4G26_01145 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) G4G26_01155 ENOG4105D03 DNA-3-methyladenine glycosylase II G4G26_01165 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G4G26_01170 ENOG4108TWJ NADH dehydrogenase subunit 5 G4G26_01190 ENOG4105GPN Uncharacterized conserved protein (DUF2294) G4G26_01195 ENOG4105WAB arsR family transcriptional regulator G4G26_01200 ENOG4108RWP Major Facilitator Superfamily protein G4G26_01215 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin G4G26_01235 ENOG4105BZ1 (ABC) transporter G4G26_01260 ENOG4105G0J serine threonine protein kinase G4G26_01270 ENOG4106K80 G4G26_01280 ENOG4106DDH Sporulation-specific SASP protein G4G26_01290 ENOG4108HWY Beta-lactamase G4G26_01295 ENOG4107E6A Cytochrome p-450 G4G26_01305 ENOG4107QTZ amino acid G4G26_01310 ENOG4107VXM glycerophosphoryl diester phosphodiesterase G4G26_01315 ENOG4105CXY transporter G4G26_01325 ENOG410645S MarR family Transcriptional regulator G4G26_01330 ENOG4105DCM major facilitator superfamily G4G26_01345 ENOG410631K Membrane G4G26_01350 ENOG4106AXJ AraC family transcriptional regulator G4G26_01355 ENOG41065RQ ADP-ribosylation crystallin J1 G4G26_01360 ENOG4106BHF G4G26_01365 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR G4G26_01370 ENOG4108TCS Glutamyl endopeptidase G4G26_01380 ENOG4108WC5 Alpha Beta Hydrolase Fold protein G4G26_01385 ENOG4106PT6 cdpdiacylglycerol-serine O-phosphatidyltransferase G4G26_01390 ENOG4107ZTW SNARE associated Golgi G4G26_01410 ENOG4105C72 UPF0176 protein G4G26_01420 ENOG4108IIZ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane G4G26_01425 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) G4G26_01440 ENOG4105CM2 brancheD-chain amino acid aminotransferase G4G26_01445 ENOG4108IQI permease G4G26_01450 ENOG4108J5H Homocysteine s-methyltransferase G4G26_01465 ENOG4105CSV Glutaminase G4G26_01480 ENOG4105UVJ 5-dehydro-4-deoxyglucarate dehydratase G4G26_01485 ENOG4105C26 Dehydrogenase G4G26_01490 ENOG4105DJB Major Facilitator Superfamily G4G26_01495 ENOG4105EQX glucarate dehydratase G4G26_01500 ENOG41073TP transcriptional regulator G4G26_01505 ENOG4105CTX dehydratase G4G26_01520 ENOG4106UX7 integral membrane protein G4G26_01525 ENOG4105DPZ Two component transcriptional regulator (Winged helix family G4G26_01560 ENOG4105MUA Resistance protein G4G26_01570 ENOG4105DGI Alkaline phosphatase G4G26_01575 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) G4G26_01580 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) G4G26_01585 ENOG4108KN7 Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity) G4G26_01590 ENOG4107EPV Aminotransferase class V G4G26_01595 ENOG4105C0R drug resistance transporter emrb qaca subfamily G4G26_01600 ENOG4105J7D transcriptional regulator G4G26_01605 ENOG4107RB3 L-asparaginase G4G26_01610 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold G4G26_01620 ENOG41060AI SEC-C motif G4G26_01630 ENOG4107Y7X LytTR G4G26_01635 ENOG4108IUW ABC transporter G4G26_01640 ENOG4108SDH ABC, transporter G4G26_01645 ENOG4107SET aldo keto reductase G4G26_01680 ENOG4105H9W Short-chain dehydrogenase reductase Sdr G4G26_01690 ENOG4105DSE periplasmic solute binding protein G4G26_01695 ENOG4105DIK (ABC) transporter G4G26_01705 ENOG4105DEN Luciferase family G4G26_01710 ENOG4108N0M stress protein G4G26_01715 ENOG4106FN3 tellurium resistance protein G4G26_01720 ENOG4106FN3 tellurium resistance protein G4G26_01725 ENOG4107TS3 membrane protein, TerC G4G26_01730 ENOG4108TTB tellurium resistance protein G4G26_01740 ENOG41079KZ Major Facilitator Superfamily G4G26_01750 ENOG4108A65 Transcriptional regulator G4G26_01755 ENOG4108IJ7 Glycine betaine G4G26_01760 ENOG4107SQ8 Glycine betaine G4G26_01790 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) G4G26_01825 ENOG4105EIG urea carboxylase-associated protein 1 G4G26_01830 ENOG4107RA1 nh(3)-dependent nad( ) synthetase G4G26_01835 ENOG4105I1F Resistance protein G4G26_01840 ENOG4107Z3Y Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) G4G26_01845 ENOG41089UC methyltransferase, type 11 G4G26_01850 ENOG4105C5Q Transcriptional regulator G4G26_01855 ENOG4105I82 acetyl xylan esterase G4G26_01860 ENOG410756H nucleotidyltransferase G4G26_01870 ENOG4105C26 Dehydrogenase G4G26_01875 ENOG4105CK7 Sodium proline symporter G4G26_01880 ENOG4107YHD transcriptional regulator G4G26_01890 ENOG4108PJD permease G4G26_01895 ENOG4105U6C Alpha beta hydrolase fold protein G4G26_01905 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G4G26_01910 ENOG4105KH3 nitrite reductase (NAD(P)h) small subunit G4G26_01915 ENOG4108IFG nitrite reductase, (NAD(P)H) G4G26_01920 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) G4G26_01940 ENOG4105S7A ErfK ybiS ycfS ynhG family protein G4G26_01950 ENOG4105CKI cobalamin synthesis protein G4G26_01955 ENOG4105E5Q amino acid AbC transporter G4G26_01960 ENOG4107XKZ Amino acid ABC superfamily ATP binding cassette transporter binding protein G4G26_01980 ENOG4105CS2 ec 3.2.1.21 G4G26_01995 ENOG4105C8Q Methyl-accepting chemotaxis G4G26_02000 ENOG41080HJ 6-phospho 3-hexuloisomerase G4G26_02005 ENOG4108VA3 3-hexulose-6-phosphate synthase G4G26_02010 ENOG4105KVH Transcriptional regulator G4G26_02015 ENOG4105CEY Amp-dependent synthetase and ligase G4G26_02045 ENOG4105SX7 Transporter G4G26_02055 ENOG4105W8Z 4'-phosphopantetheinyl transferase G4G26_02065 ENOG4105CDA abc transporter atp-binding protein G4G26_02070 ENOG4105DRP amino acid AbC transporter G4G26_02080 ENOG4106P55 Transcriptional regulator G4G26_02085 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase G4G26_02090 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) G4G26_02095 ENOG41069ZX G4G26_02100 ENOG41069ZX G4G26_02110 ENOG4105DUX Transporter G4G26_02125 ENOG4105E1K spore germination protein G4G26_02145 ENOG4107WD8 ABC transporter, permease G4G26_02150 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G4G26_02155 ENOG4105BZU Histidine kinase G4G26_02180 ENOG4105CFH Aspartokinase G4G26_02185 ENOG4105DHS permease protein G4G26_02190 ENOG4105CM4 permease protein G4G26_02195 ENOG4108IPW abc transporter atp-binding protein G4G26_02210 ENOG4105R8C Transcriptional regulator G4G26_02215 ENOG4108DBC nitroreductase G4G26_02220 ENOG41067V3 Antibiotic biosynthesis monooxygenase G4G26_02225 ENOG4105YVS arsR family transcriptional regulator G4G26_02235 ENOG4108JPW Aminotransferase G4G26_02240 ENOG4105C26 Dehydrogenase G4G26_02250 ENOG4105H9W Short-chain dehydrogenase reductase Sdr G4G26_02255 ENOG4105KTB nuclear export factor GLE1 G4G26_02260 ENOG4108T5E Copper resistance protein G4G26_02265 ENOG4108ZYE Transcriptional regulator G4G26_02290 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G4G26_02295 ENOG4108ZX0 Signal peptidase I G4G26_02320 ENOG4105E7W lamb ycsf family protein G4G26_02325 ENOG4105C5A transporter G4G26_02330 ENOG4105CFM UPF0317 protein G4G26_02335 ENOG4105P4J Allophanate hydrolase, subunit 1 G4G26_02345 ENOG4107258 Transcriptional regulator G4G26_02350 ENOG4105XJB lipolytic protein G-D-S-L family G4G26_02360 ENOG41061CK Antibiotic biosynthesis monooxygenase G4G26_02365 ENOG4107RVG penicillin-binding protein G4G26_02370 ENOG4107QM2 Aldo Keto reductase G4G26_02375 ENOG4105ETD TRANSCRIPTIONal G4G26_02385 ENOG4105HMZ Methyltransferase G4G26_02390 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G4G26_02405 ENOG410606W general stress protein G4G26_02415 ENOG4105VCH membrane G4G26_02425 ENOG4105C9U ATP-dependent DNA helicase RecQ G4G26_02440 ENOG4105I5R Uncharacterized protein conserved in bacteria (DUF2334) G4G26_02445 ENOG4107R8N Glycosyl transferase, family 2 G4G26_02455 ENOG4105C0X amino acid G4G26_02480 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) G4G26_02490 ENOG4105NRR Uncharacterized protein conserved in bacteria (DUF2188) G4G26_02495 ENOG4105EU9 G4G26_02500 ENOG4105QVS general stress protein G4G26_02505 ENOG41082W1 Cupin 2, conserved barrel domain protein G4G26_02520 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit G4G26_02525 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism G4G26_02530 ENOG4108MRH transcriptional regulatory protein G4G26_02535 ENOG4107QJT sodium dicarboxylate symporter G4G26_02540 ENOG4106F5Q Membrane G4G26_02545 ENOG4105CJ1 ABC, transporter G4G26_02560 ENOG4105FDT acyl-CoA dehydrogenase G4G26_02580 ENOG4105SZ6 Thioredoxin G4G26_02585 ENOG4105CPF Cell wall formation (By similarity) G4G26_02590 ENOG4107EES Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide the precursor of murein (By similarity) G4G26_02595 ENOG4105C1J atp-dependent rna helicase G4G26_02600 ENOG410905X membrane-flanked domain protein G4G26_02605 ENOG4105CKV Membrane G4G26_02615 ENOG41082V8 Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) G4G26_02620 ENOG4108SGW outer membrane lipoprotein-sorting protein-like protein G4G26_02625 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) G4G26_02635 ENOG4108YZM Toxic component of a toxin-antitoxin (TA) module (By similarity) G4G26_02640 ENOG4107MMM Anti-sigma-factor antagonist G4G26_02645 ENOG4105FUA antagonist G4G26_02650 ENOG4105QD0 anti-sigma regulatory factor serine threonine protein kinase G4G26_02655 ENOG4107SGM protein serine threonine phosphatase G4G26_02660 ENOG4105WN5 stage II sporulation protein G4G26_02665 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) G4G26_02675 ENOG41064BQ Phosphatase G4G26_02740 ENOG4105VZ8 Transcriptional regulator G4G26_02765 ENOG4108V4B ThiJ pfpI G4G26_02770 ENOG4105VEQ Cold shock protein G4G26_02775 ENOG4108VJ1 Transcriptional regulator (CarD family G4G26_02785 ENOG4108MCI Transcriptional regulator, ARAC family G4G26_02790 ENOG4108UZ3 Transporter G4G26_02795 ENOG41086D8 Transcriptional regulator G4G26_02800 ENOG4107U9B transcriptional regulator G4G26_02805 ENOG4105DXI Major Facilitator superfamily G4G26_02815 ENOG4105CZ9 Domain of unknown function (DU1801) G4G26_02820 ENOG4105GIG G4G26_02825 ENOG4105KRI phosphocarrier protein (HPr G4G26_02830 ENOG4105ST3 Transcriptional regulator G4G26_02835 ENOG4105T38 integral membrane protein G4G26_02840 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G4G26_02845 ENOG4108ZMQ domain protein G4G26_02850 ENOG4105MJ9 esterase G4G26_02855 ENOG4107Z6X Transcriptional regulator G4G26_02865 ENOG4105EQ0 Major Facilitator superfamily G4G26_02870 ENOG4108JGH Tetr family transcriptional regulator G4G26_02880 ENOG41082YX Transcriptional regulator, arsr family G4G26_02885 ENOG4107R5R arsenical pump membrane protein G4G26_02895 ENOG4105Z7P Acetyltransferase (GNAT) family G4G26_02900 ENOG4107Y9U Membrane G4G26_02910 ENOG4108SQ9 flavin reductase domain protein, FMN-binding G4G26_02915 ENOG4108ZHR arsR family transcriptional regulator G4G26_02920 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G4G26_02935 ENOG4105ENE Histidine kinase G4G26_02940 ENOG4108VB1 regulatoR G4G26_02945 ENOG4105EYF MMPL domain protein G4G26_02950 ENOG4108WC5 Alpha Beta Hydrolase Fold protein G4G26_02955 ENOG4108UQV Membrane G4G26_02960 ENOG4108Z5V transcriptional regulator, merr family G4G26_02965 ENOG41076HS cation diffusion facilitator family transporter G4G26_02970 ENOG4108TVJ Nitroreductase G4G26_02975 ENOG4105DA2 glyoxalase bleomycin resistance protein dioxygenase G4G26_02980 ENOG4108VGI doxx family G4G26_02985 ENOG4105XXY Thioredoxin G4G26_03005 ENOG410900G Protein of unknown function (DUF421) G4G26_03010 ENOG4108QY0 Membrane G4G26_03030 ENOG4105PF9 Transcriptional regulator G4G26_03040 ENOG4105WQG acetyltransferase G4G26_03050 ENOG4105C85 amino acid G4G26_03060 ENOG41062A4 Transcriptional regulator G4G26_03065 ENOG4105EYF MMPL domain protein G4G26_03070 ENOG4108TVJ Nitroreductase G4G26_03075 ENOG4105FS7 Transcriptional regulator G4G26_03080 ENOG4105C2C drug resistance transporter, Bcr CflA G4G26_03090 ENOG4105DRR Transcriptional regulator, GntR family G4G26_03095 ENOG4105VRS hydrolase family 18 G4G26_03110 ENOG4105G6Z alkaline phosphatase G4G26_03115 ENOG4108ZMX Domain of unknown function (DU1801) G4G26_03125 ENOG4108YM7 Gcn5-related n-acetyltransferase G4G26_03130 ENOG4107TVP HD domain protein G4G26_03135 ENOG41090UD (LipO)protein G4G26_03140 ENOG4105F27 Major Facilitator G4G26_03145 ENOG4105VZJ PTS System G4G26_03150 ENOG4105VCP PTS System G4G26_03155 ENOG4105CK1 PTS System G4G26_03160 ENOG4105CS2 ec 3.2.1.21 G4G26_03165 ENOG4108TZY GntR Family Transcriptional Regulator G4G26_03170 ENOG4105EVU fructokinase G4G26_03175 ENOG4105DG6 mannose-6-phosphate isomerase G4G26_03180 ENOG4105D3P Mannan endo-1,4-beta-mannosidase G4G26_03225 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) G4G26_03230 ENOG4105K8N protein family UPF0079, ATPase G4G26_03235 ENOG41072GX Peptidase M22 Glycoprotease G4G26_03240 ENOG410801F ribosomal-protein-alanine acetyltransferase G4G26_03245 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) G4G26_03250 ENOG4105C5H ABC transporter G4G26_03255 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) G4G26_03260 ENOG4105FF6 Modulates transcription in response to changes in cellular NADH NAD( ) redox state (By similarity) G4G26_03265 ENOG41067S4 Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) G4G26_03270 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) G4G26_03280 ENOG4108TYN CAAX amino terminal protease family protein G4G26_03290 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) G4G26_03305 ENOG4105PGZ NB-ARC domain G4G26_03310 ENOG4105CPQ Dehydrogenase G4G26_03315 ENOG4105CT4 transporter G4G26_03325 ENOG41087YS Phage shock protein A G4G26_03330 ENOG4105DQX Zinc finger domain G4G26_03335 ENOG4108WV1 Pfam:DUF477 G4G26_03345 ENOG4108ZMR Ion transport 2 domain-containing protein G4G26_03350 ENOG4107QNK )-transporter G4G26_03380 ENOG4107YUH hydrolase G4G26_03390 ENOG4107STQ Multicopper oxidase G4G26_03395 ENOG4105C85 amino acid G4G26_03410 ENOG4105C7R Atpase associated with various cellular activities aaa_3 G4G26_03440 ENOG4105C7N Xanthine uracil vitamin C permease G4G26_03465 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) G4G26_03470 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit G4G26_03475 ENOG4105C83 adenylosuccinate lyase G4G26_03480 ENOG4105C8V SAICAR synthetase G4G26_03485 ENOG4105VR9 phosphoribosylformylglycinamidine synthase G4G26_03490 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I G4G26_03495 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii G4G26_03505 ENOG4105CXB phosphoribosylaminoimidazole synthetase G4G26_03510 ENOG4108V3E phosphoribosylglycinamide formyltransferase G4G26_03515 ENOG4105DC1 bifunctional purine biosynthesis protein purh G4G26_03520 ENOG4105C12 Phosphoribosylglycinamide synthetase G4G26_03530 ENOG4105DVH amino acid G4G26_03545 ENOG4108R5T secreted protein G4G26_03550 ENOG4105KGF protein, YerC YecD G4G26_03555 ENOG4105CBC glutamate synthase G4G26_03560 ENOG4108RTE 35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales (By similarity) G4G26_03565 ENOG4105C4R Atp-dependent dna helicase G4G26_03570 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) G4G26_03580 ENOG4105CRN Aminoglycoside phosphotransferase G4G26_03585 ENOG4105KT7 mgtC SapB transporter G4G26_03590 ENOG4105CK7 Sodium proline symporter G4G26_03595 ENOG4105VB5 Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) G4G26_03600 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G4G26_03605 ENOG4105CHT Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity) G4G26_03610 ENOG4108IG5 Transcriptional regulator G4G26_03620 ENOG4105CBD Diacylglycerol kinase G4G26_03625 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) G4G26_03675 ENOG4105CDY transcriptional regulatory protein G4G26_03685 ENOG4105M4P Tetr family transcriptional regulator G4G26_03690 ENOG41062KD Inherit from COG: ketosteroid isomerase-like protein G4G26_03695 ENOG4107S9F NmrA family G4G26_03710 ENOG4105WEF catalase G4G26_03715 ENOG4105M18 -acetyltransferase G4G26_03730 ENOG4105C2F Histidine kinase G4G26_03735 ENOG4105EQD regulatoR G4G26_03740 ENOG410769Z extracellular solute-binding protein family 1 G4G26_03745 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component G4G26_03750 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component G4G26_03755 ENOG4105F5H Glycosyl Hydrolase Family 88 G4G26_03760 ENOG41075H3 AraC family transcriptional regulator G4G26_03765 ENOG4107TDE lipolytic protein G-D-S-L family G4G26_03780 ENOG4105CX8 fg-gap repeat protein G4G26_03785 ENOG4105CX8 fg-gap repeat protein G4G26_03790 ENOG4107TDE lipolytic protein G-D-S-L family G4G26_03800 ENOG4105EKC G4G26_03805 ENOG4105E0S extracellular solute-binding protein family 1 G4G26_03815 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component G4G26_03820 ENOG4105F8D glycoside hydrolase family 4 G4G26_03825 ENOG4105H67 Protein of unknown function (DUF421) G4G26_03830 ENOG4105Z26 Allows bacterial pathogens to use the host heme as an iron source. Catalyzes the oxidative degradation of the heme macrocyclic porphyrin ring to the oxo-bilirubin chromophore staphylobilin (a mixture of the linear tetrapyrroles 5-oxo-delta- bilirubin and 15-oxo-beta-bilirubin) in the presence of a suitable electron donor such as ascorbate or NADPH--cytochrome P450 reductase, with subsequent release of free iron (By similarity) G4G26_03835 ENOG41083WA Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily G4G26_03855 ENOG4106I4J membrane G4G26_03860 ENOG4108PCN EamA-like transporter family G4G26_03865 ENOG41082F9 transcriptional regulator G4G26_03870 ENOG41061H0 Monooxygenase G4G26_03880 ENOG4108R1P G4G26_03885 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G4G26_03890 ENOG4105E0M Sulfatase G4G26_03895 ENOG4105EJZ Glucose-1-phosphate cytidylyltransferase G4G26_03905 ENOG41090R9 glycosyltransferase G4G26_03910 ENOG4107R51 Glycosyl transferase, family 2 G4G26_03915 ENOG41090R9 glycosyltransferase G4G26_03920 ENOG4105EU0 Major facilitator Superfamily G4G26_03930 ENOG4105CUB amino acid G4G26_03935 ENOG4105C26 Dehydrogenase G4G26_03940 ENOG4105FKZ Methyl-accepting chemotaxis G4G26_03945 ENOG4105C5H ABC transporter G4G26_03955 ENOG4107SWG transcriptional regulator MERR family G4G26_03960 ENOG4105DXB Major Facilitator superfamily G4G26_03970 ENOG4105C5H ABC transporter G4G26_03975 ENOG4105FDU atp-dependent rna helicase G4G26_03985 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein G4G26_03995 ENOG4105E6M Sulphatase-modifying factor protein G4G26_04000 ENOG4105E0A ABC, transporter G4G26_04005 ENOG4108U1V ABC transporter, permease G4G26_04010 ENOG4105DQ5 transport system permease protein G4G26_04015 ENOG4108HUF Transporter G4G26_04030 ENOG4108J20 pectate lyase G4G26_04035 ENOG4107QPK )-transporter G4G26_04045 ENOG4108MRH transcriptional regulatory protein G4G26_04070 ENOG410855V Acylphosphatase G4G26_04075 ENOG4108RPX mosc domain containing protein G4G26_04095 ENOG4106A4F Removes the N-terminal methionine from nascent proteins (By similarity) G4G26_04125 ENOG4105GEU Spore germination protein G4G26_04135 ENOG4108Q5U germination protein, ger(x)c family G4G26_04145 ENOG4105C5Y PTS System G4G26_04150 ENOG4105CG3 alpha amylase, catalytic region G4G26_04155 ENOG4107414 GntR family transcriptional regulator G4G26_04160 ENOG4108RCM Nitroreductase G4G26_04165 ENOG4105CGH 5'-nucleotidase G4G26_04170 ENOG4107RKG DJ-1/PfpI family G4G26_04185 ENOG4105KJF protein tyrosine phosphatase G4G26_04195 ENOG4107U9T Pfam:Ribonuclease_BN G4G26_04200 ENOG4108ISG Major Facilitator G4G26_04205 ENOG4105UPD Calcium Proton G4G26_04215 ENOG4105D8X mechanosensitive ion channel G4G26_04235 ENOG4106KE4 Dehydrogenase G4G26_04240 ENOG4105D7N magnesium and cobalt transport protein CorA G4G26_04250 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) G4G26_04270 ENOG4107RUY (E1 component), alpha subunit G4G26_04280 ENOG4107QKR Dehydrogenase G4G26_04290 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family G4G26_04295 ENOG41069DP small acid-soluble spore protein G4G26_04300 ENOG4105KK4 UPF0060 membrane protein G4G26_04325 ENOG4105F8D glycoside hydrolase family 4 G4G26_04330 ENOG4108Q3X Transcriptional regulator G4G26_04335 ENOG4105CI1 PTS System G4G26_04340 ENOG4105BZ1 (ABC) transporter G4G26_04345 ENOG4105BZ1 (ABC) transporter G4G26_04355 ENOG4108TKW Glyoxalase Bleomycin resistance protein (Dioxygenase G4G26_04360 ENOG4105BZU Histidine kinase G4G26_04365 ENOG4105WH1 Two component transcriptional regulator luxr family G4G26_04370 ENOG4105CJ1 ABC, transporter G4G26_04375 ENOG41090VJ ABC-2 type transporter G4G26_04380 ENOG4108KYE ABC-2 type transporter G4G26_04385 ENOG4105U3E Transcriptional regulator G4G26_04390 ENOG4108KTS Acetyltransferase and hydrolase with the alpha beta hydrolase fold G4G26_04395 ENOG4105H93 Acyltransferase family G4G26_04400 ENOG4108YYS metal-dependent hydrolase (By similarity) G4G26_04405 ENOG4105C0R drug resistance transporter emrb qaca subfamily G4G26_04410 ENOG410834F Transcriptional regulator G4G26_04420 ENOG4108MES Periplasmic binding protein G4G26_04425 ENOG4105DQ5 transport system permease protein G4G26_04430 ENOG4108IHU transport system permease protein G4G26_04435 ENOG4105JAB phenazine biosynthesis protein, phzf family G4G26_04440 ENOG4107Y03 Nitroreductase G4G26_04455 ENOG4105ECP epimerase G4G26_04470 ENOG4105F27 Major Facilitator G4G26_04490 ENOG4106AKJ G4G26_04495 ENOG4105D74 hydrolase G4G26_04500 ENOG4105CKK Glycosyl transferase, family 2 G4G26_04505 ENOG4105EJV Membrane G4G26_04510 ENOG41067AE Membrane-bound metal-dependent hydrolase G4G26_04515 ENOG4105CEN a g-specific adenine glycosylase G4G26_04520 ENOG4106BXE G4G26_04525 ENOG4105CAN Short-chain dehydrogenase reductase Sdr G4G26_04540 ENOG4105EVI UPF0374 protein G4G26_04545 ENOG4105BZ1 (ABC) transporter G4G26_04550 ENOG4107NBY Membrane G4G26_04560 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G4G26_04565 ENOG4105G5W regulator Fur family G4G26_04675 ENOG4108N23 SpoOM-related protein G4G26_04690 ENOG4105EC3 peptidase S51, dipeptidase E G4G26_04695 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) G4G26_04700 ENOG4105DNP FAD linked oxidase domain protein G4G26_04715 ENOG4105E2Y ABC, transporter G4G26_04720 ENOG4108J8Z aliphatic sulfonates family ABC transporter periplasmic ligand-binding protein G4G26_04725 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G4G26_04730 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) G4G26_04740 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) G4G26_04745 ENOG4107D63 G4G26_04750 ENOG4105VZ8 Transcriptional regulator G4G26_04765 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) G4G26_04775 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) G4G26_04795 ENOG4105CYN Serine protein kinase G4G26_04800 ENOG4106AKX UPF0229 protein G4G26_04805 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes G4G26_04810 ENOG4105CW7 secretion protein, HlyD family G4G26_04815 ENOG4105C0R drug resistance transporter emrb qaca subfamily G4G26_04820 ENOG4105CS1 NAD(P)H quinone oxidoreductase G4G26_04840 ENOG4105W8V TRANSCRIPTIONAl REGULATOR GntR family G4G26_04845 ENOG4105CZV ABC transporter G4G26_04850 ENOG4105CJ1 ABC, transporter G4G26_04855 ENOG4108TU7 Inherit from COG: (ABC) transporter G4G26_04860 ENOG4105VEQ Cold shock protein G4G26_04870 ENOG4105BZU Histidine kinase G4G26_04910 ENOG4108YBP pseudouridine synthase G4G26_04920 ENOG41080XP Cbs domain G4G26_04925 ENOG4107YBY Hydrolase G4G26_04930 ENOG4105DGM nitrilase cyanide hydratase and apolipoprotein n-acyltransferase G4G26_04935 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G4G26_04940 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator G4G26_04950 ENOG4108HMR Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) G4G26_04955 ENOG4105C6V Glycerol-3-phosphate dehydrogenase G4G26_04965 ENOG4105BZU Histidine kinase G4G26_04970 ENOG4105WH1 Two component transcriptional regulator luxr family G4G26_05005 ENOG4105ED1 spovr family G4G26_05010 ENOG4105G6Z alkaline phosphatase G4G26_05025 ENOG4105BZN citrate synthase G4G26_05030 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G4G26_05035 ENOG4105CUB amino acid G4G26_05040 ENOG4105C8J )-transporter G4G26_05045 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G4G26_05060 ENOG4105J37 G4G26_05065 ENOG4108AEY RNA polymerase sigma factor G4G26_05070 ENOG4108FN7 Aldo keto reductase G4G26_05075 ENOG4105F6E Acyl-transferase G4G26_05080 ENOG4105C37 (CBS) domain G4G26_05090 ENOG4105CHM Aminotransferase G4G26_05095 ENOG4105C37 (CBS) domain G4G26_05105 ENOG4105WMR Protein CrcB homolog G4G26_05110 ENOG4108QXE glycerophosphoryl diester phosphodiesterase G4G26_05120 ENOG4105D64 Mechanosensitive ion channel G4G26_05125 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) G4G26_05130 ENOG4107VMI polysaccharide deacetylase G4G26_05135 ENOG4105F0I Aminotransferase G4G26_05155 ENOG4105BZ1 (ABC) transporter G4G26_05160 ENOG4105BZ1 (ABC) transporter G4G26_05185 ENOG410839P G4G26_05195 ENOG4106MP8 UPF0754 membrane protein G4G26_05200 ENOG4105WZB UPF0342 protein G4G26_05205 ENOG4105F1N DNA alkylation repair G4G26_05215 ENOG4105D4P Coproporphyrinogen iii oxidase G4G26_05220 ENOG4107S91 Sodium hydrogen exchanger G4G26_05225 ENOG4105NCW Trka-c domain protein G4G26_05235 ENOG4105CGU Enoyl-CoA hydratase G4G26_05245 ENOG4108IUX (ABC) transporter G4G26_05250 ENOG4105RHA ABC transporter, permease G4G26_05255 ENOG4107VRP DNA repair exonuclease G4G26_05260 ENOG4106D4I domain protein G4G26_05265 ENOG4105EQI Metal Dependent Phosphohydrolase G4G26_05275 ENOG4107UUG Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins (By similarity) G4G26_05320 ENOG4105NBU tryptophan transport protein G4G26_05325 ENOG4105DXJ Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) G4G26_05330 ENOG4105K59 histidine triad (HIT) protein G4G26_05365 ENOG4105Q24 Signal transduction protein, which is a major regulator of staphylococcal pathogenesis. Phosphorylated TRAP leads to the activation of agr system and consequent RNAIII synthesis resulting in the expression of several virulence factors. Upregulates the expression of most toxins and genes known to be necessary for biofilm formation G4G26_05370 ENOG4105BZ4 penicillin-binding protein G4G26_05375 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) G4G26_05380 ENOG4107TTW Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) G4G26_05385 ENOG4105C1Q protoporphyrinogen oxidase G4G26_05395 ENOG4105ECB domain protein G4G26_05405 ENOG41090T1 Membrane G4G26_05415 ENOG4105DER m42 family G4G26_05430 ENOG4106AXD G4G26_05435 ENOG4108RQ5 Beta-lactamase domain-containing protein G4G26_05440 ENOG4105DF9 Lipoate-protein, ligase G4G26_05450 ENOG4105CEY Amp-dependent synthetase and ligase G4G26_05460 ENOG4105C2Y STE24 endopeptidase EC 3.4.24.84 G4G26_05470 ENOG4105KD7 acetyltransferase G4G26_05480 ENOG4108HUF Transporter G4G26_05485 ENOG4107TB6 phosphoglycerate mutase G4G26_05495 ENOG4107F3J Amp-dependent synthetase and ligase G4G26_05500 ENOG4107ZYJ bioY protein G4G26_05505 ENOG4106YBV Methyl-accepting chemotaxis G4G26_05525 ENOG4105XVF Competence transcription factor G4G26_05530 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G4G26_05535 ENOG4105X3H Excalibur domain protein G4G26_05540 ENOG4105E1V na solute symporter G4G26_05545 ENOG4106CAD Protein of unknown function (DUF3311) G4G26_05550 ENOG41060YP G4G26_05565 ENOG4107SCK Monooxygenase G4G26_05570 ENOG4108INS Transcriptional regulator G4G26_05590 ENOG4105TRI Hydrolase G4G26_05605 ENOG4108KK1 membrane protein AbrB duplication G4G26_05610 ENOG4106K7D Major facilitator family transporter G4G26_05615 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) G4G26_05620 ENOG4105VWP Inherit from COG: 4Fe-4S ferredoxin, iron-sulfur binding G4G26_05635 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation G4G26_05645 ENOG4105EYH Exonuclease G4G26_05695 ENOG4105ERH Fumarylacetoacetate hydrolase G4G26_05705 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin G4G26_05715 ENOG4105CAQ asparagine synthetase G4G26_05730 ENOG4105UQX Mate efflux family protein G4G26_05735 ENOG4106HBX Transcriptional Regulator AraC Family G4G26_05740 ENOG4105ETE Transcriptional regulator (LacI family G4G26_05745 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) G4G26_05750 ENOG4105SF0 DinB family G4G26_05755 ENOG4108ZUB Lysine exporter protein (Lyse ygga) G4G26_05760 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G4G26_05765 ENOG4105MYW Pentapeptide repeat protein G4G26_05770 ENOG4107S9D Alpha beta hydrolase G4G26_05775 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) G4G26_05780 ENOG4107RIQ Sulfate adenylate transferase G4G26_05785 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) G4G26_05790 ENOG4108N5B 2-phosphosulfolactate phosphatase G4G26_05795 ENOG41061P3 phosphosulfolactate synthase G4G26_05805 ENOG4105DIA mandelate racemase muconate lactonizing G4G26_05810 ENOG4107RCC Major Facilitator Superfamily G4G26_05815 ENOG4108SZE gCN5-related N-acetyltransferase G4G26_05820 ENOG4105MA6 gCN5-related N-acetyltransferase G4G26_05830 ENOG4108VPT UPF0234 protein G4G26_05835 ENOG4105QNR S1 RNA binding domain protein G4G26_05855 ENOG4105K7K Transcriptional regulator G4G26_05865 ENOG410751J G4G26_05870 ENOG4105D4Y metalloprotease G4G26_05875 ENOG4105EPR degv family G4G26_05880 ENOG4107AYK membrAne G4G26_05890 ENOG41073B9 G4G26_05900 ENOG4108KP7 hydrolase G4G26_05905 ENOG4108MXZ Esterase G4G26_05910 ENOG4105VG1 fes assembly suf system protein G4G26_05920 ENOG4105IQ5 FAD linked oxidase domain protein G4G26_05930 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase G4G26_05935 ENOG4105C5V Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity) G4G26_05945 ENOG4105C8Y Acetylornithine aminotransferase G4G26_05950 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain G4G26_05960 ENOG4105DBV ornithine carbamoyltransferase G4G26_05985 ENOG4107RMD Basic membrane lipoprotein G4G26_06000 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G4G26_06005 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G4G26_06015 ENOG4105C3U ABC transporter G4G26_06020 ENOG4108JQ7 (ABC) transporter G4G26_06035 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G4G26_06045 ENOG4105C31 Tryptophanyl-tRNA synthetase G4G26_06050 ENOG4108J59 Extracellular solute-binding protein, family 5 G4G26_06055 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G4G26_06060 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G4G26_06070 ENOG4108JQ7 (ABC) transporter G4G26_06085 ENOG41090SU Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity) G4G26_06090 ENOG4108ZCF integral membrane protein G4G26_06100 ENOG4108SQ7 Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis G4G26_06115 ENOG4105DPN Oligoendopeptidase f G4G26_06125 ENOG4105T58 Dithiol-disulfide isomerase G4G26_06130 ENOG4108Z18 K06886 hemoglobin G4G26_06135 ENOG4105E4C Lytic transglycosylase catalytic G4G26_06140 ENOG4105MIX Adenylate cyclase G4G26_06155 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) G4G26_06160 ENOG4105EMS pseudouridine synthase G4G26_06175 ENOG4105ETU transcriptional activator (TenA G4G26_06180 ENOG4108VEU Thiamine monophosphate synthase G4G26_06195 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) G4G26_06200 ENOG4105D06 uba thif-type nad fad binding protein G4G26_06205 ENOG4105DWF phosphomethylpyrimidine kinase G4G26_06210 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH G4G26_06215 ENOG4107A88 G4G26_06265 ENOG4105ENA helicase G4G26_06280 ENOG4108ZMI UPF0477 protein G4G26_06290 ENOG4105C28 cystathionine G4G26_06295 ENOG4105C28 cystathionine G4G26_06300 ENOG4105D9U N-acetyltransferase G4G26_06305 ENOG4105JHY Membrane G4G26_06325 ENOG4106BHF G4G26_06380 ENOG4108PSK reductase G4G26_06395 ENOG4105DM4 PTS System G4G26_06400 ENOG4105DG6 mannose-6-phosphate isomerase G4G26_06405 ENOG4105G7B Protein of unknown function (DUF2992) G4G26_06410 ENOG4105VMI -acetyltransferase G4G26_06420 ENOG4108Z66 YbaK ebsC protein G4G26_06435 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) G4G26_06445 ENOG4108ZJ4 polysaccharide deacetylase G4G26_06450 ENOG4107CUJ Protein of unknown function (DUF2690) G4G26_06475 ENOG4108IEG Formate dehydrogenase Alpha subunit G4G26_06500 ENOG4106A3M Cytochrome p-450 G4G26_06505 ENOG41087PP glycosyltransferase MGT family G4G26_06515 ENOG4105EXQ uroporphyrinogen iii synthase hem4 G4G26_06520 ENOG4105C4B ABC transporter, permease G4G26_06525 ENOG4108IXI (ABC) transporter G4G26_06535 ENOG4105Q95 Cupin 2, conserved barrel domain protein G4G26_06550 ENOG4105D2H Uronic isomerase G4G26_06555 ENOG4105CT4 transporter G4G26_06560 ENOG4105DG4 malate L-lactate dehydrogenase G4G26_06565 ENOG4105CPQ Dehydrogenase G4G26_06570 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) G4G26_06575 ENOG4105DMW Dehydrogenase reductase G4G26_06580 ENOG4108I5G Major Facilitator superfamily G4G26_06585 ENOG4107KJX Transcriptional regulator G4G26_06590 ENOG4107QZW Altronate oxidoreductase G4G26_06595 ENOG4105CTX dehydratase G4G26_06600 ENOG4107TSN permease G4G26_06610 ENOG4105JD4 ATPase yjob G4G26_06625 ENOG41068K0 YCII-related domain G4G26_06630 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase G4G26_06635 ENOG4105KWG Pfam:DUF1696 G4G26_06640 ENOG4105K7W phage-related replication protein G4G26_06645 ENOG4105WEF catalase G4G26_06650 ENOG410635T phage-like element pbsx protein G4G26_06695 ENOG4108TFU terminase (Small subunit) G4G26_06700 ENOG4105IG6 Phage terminase, large subunit G4G26_06705 ENOG4108MDF Phage Portal Protein G4G26_06730 ENOG41060SN G4G26_06745 ENOG4105PQS phage protein G4G26_06750 ENOG4105FR7 XkdM protein, phage-like element PBSX G4G26_06755 ENOG4105MTC XkdN-like protein G4G26_06765 ENOG4108FKH Transglycosylase SLT domain G4G26_06765 ENOG4108FKH Transglycosylase SLT domain G4G26_06770 ENOG4108WZM domain protein G4G26_06775 ENOG4105X7F G4G26_06785 ENOG4105MFU Protein of unknown function (DUF2634) G4G26_06790 ENOG41066EA baseplate J family protein G4G26_06795 ENOG410906S phage-like element pbsx protein xkdt G4G26_06805 ENOG41068G1 G4G26_06835 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase G4G26_06855 ENOG4105CJ3 phosphate transporter G4G26_06860 ENOG4107GRR phosphate transport regulator G4G26_06865 ENOG4107R7I amino acid G4G26_06880 ENOG4105EDW glycosyl transferase, family 39 G4G26_06885 ENOG4105CKK Glycosyl transferase, family 2 G4G26_06890 ENOG4105C0H protease G4G26_06900 ENOG4108ME1 Peptidase M55 D-aminopeptidase G4G26_06905 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G4G26_06910 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G4G26_06915 ENOG4105C3U ABC transporter G4G26_06925 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A G4G26_06930 ENOG4105DTQ mandelate racemase muconate lactonizing G4G26_06935 ENOG4107SN7 NLP P60 protein G4G26_06940 ENOG4108JQ7 (ABC) transporter G4G26_06945 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) G4G26_06950 ENOG4107TUM Amidinotransferase G4G26_06955 ENOG4108S4H thioesterase Superfamily protein G4G26_06960 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G4G26_06980 ENOG4108428 Inherit from COG: -acetyltransferase G4G26_06990 ENOG41080TC multidrug resistance protein G4G26_06995 ENOG4105CIY formyltetrahydrofolate deformylase G4G26_07000 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) G4G26_07015 ENOG4105K56 Transcriptional regulator G4G26_07020 ENOG4108ZHJ Organic hydroperoxide resistance protein G4G26_07030 ENOG4107Y2X deaminase G4G26_07035 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) G4G26_07040 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin G4G26_07050 ENOG4108W7F transporter, permease G4G26_07055 ENOG4108JJB ABC transporter G4G26_07060 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein G4G26_07065 ENOG4108X43 YKOF domain protein G4G26_07070 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G4G26_07075 ENOG41062D9 Histidine kinase G4G26_07085 ENOG4106849 propeptide, pepSY amd peptidase M4 G4G26_07095 ENOG4105CJW magnesium transporter G4G26_07100 ENOG4105V75 Transcriptional regulator G4G26_07145 ENOG4105DQE DNA ligase G4G26_07150 ENOG4105FDF Could be involved in DNA repair (By similarity) G4G26_07155 ENOG4105BZU Histidine kinase G4G26_07160 ENOG4107T5V SNARE associated Golgi G4G26_07165 ENOG4107TS3 membrane protein, TerC G4G26_07170 ENOG4108WZW RNA polymerase sigma G4G26_07180 ENOG410681C small acid-soluble spore protein G4G26_07190 ENOG4105D0M Protease HtpX homolog G4G26_07210 ENOG4108TGC Acyltransferase G4G26_07215 ENOG4105BZU Histidine kinase G4G26_07220 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G4G26_07230 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) G4G26_07235 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) G4G26_07240 ENOG4105CQP nitrilase cyanide hydratase and apolipoprotein n-acyltransferase G4G26_07250 ENOG4107T6J Ribulose-1,5-bisphosphate carboxylase oxygenase large subunit G4G26_07255 ENOG4105JAS Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene) (By similarity) G4G26_07260 ENOG4107V49 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) G4G26_07265 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) G4G26_07285 ENOG4105BZU Histidine kinase G4G26_07290 ENOG41090MY MarR family Transcriptional regulator G4G26_07295 ENOG4105ER2 Ompa motb domain protein G4G26_07300 ENOG4105E14 MotA TolQ exbB proton channel G4G26_07310 ENOG4108K88 Membrane G4G26_07315 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) G4G26_07320 ENOG4107ZAE 6-carboxy-5,6,7,8-tetrahydropterin synthase G4G26_07325 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) G4G26_07330 ENOG4105CSD Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) G4G26_07340 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr G4G26_07345 ENOG4105FEA Spore maturation protein G4G26_07375 ENOG4105F0V Cell wall hydrolase G4G26_07390 ENOG4105C59 p-type ATPase G4G26_07400 ENOG4105DC7 peptidase M24 G4G26_07410 ENOG4105CID antiterminator G4G26_07420 ENOG4105KRI phosphocarrier protein (HPr G4G26_07425 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) G4G26_07435 ENOG4105F6S Spore photoproduct lyase G4G26_07445 ENOG4107WTJ Methyl-accepting chemotaxis sensory transducer G4G26_07450 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G4G26_07455 ENOG4105K4I Scp-like extracellular G4G26_07465 ENOG4105BZU Histidine kinase G4G26_07470 ENOG4105CHM Aminotransferase G4G26_07480 ENOG4107R88 Chemotaxis protein (CheV) G4G26_07485 ENOG4105UIN G4G26_07495 ENOG4107Y2H ErfK ybiS ycfS ynhG family protein G4G26_07505 ENOG4105K6S Short-chain dehydrogenase reductase Sdr G4G26_07510 ENOG4105EPM Diguanylate phosphodiesterase G4G26_07515 ENOG4107IN1 Protein of unknown function (DUF1797) G4G26_07520 ENOG4108XRC Protein of unknown function (DUF458) G4G26_07550 ENOG4105NQC Flavodoxin G4G26_07560 ENOG4105CH2 amidohydrolase G4G26_07570 ENOG4105D8X mechanosensitive ion channel G4G26_07575 ENOG4105D3R alkyl hydroperoxide reductase G4G26_07580 ENOG4107R19 alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G4G26_07595 ENOG41082CS Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) G4G26_07600 ENOG4105D06 uba thif-type nad fad binding protein G4G26_07605 ENOG4105CVM Molybdenum cofactor synthesis domain protein G4G26_07610 ENOG4108129 molybdopterin-guanine dinucleotide biosynthesis protein G4G26_07615 ENOG4108ZAF Molybdopterin G4G26_07620 ENOG41067WU Molybdopterin converting factor (Subunit 1) G4G26_07625 ENOG4105BZ1 (ABC) transporter G4G26_07630 ENOG4105BZ1 (ABC) transporter G4G26_07640 ENOG4107X8C Efflux transporter RND family MFP subunit G4G26_07645 ENOG4105C19 ABC transporter G4G26_07650 ENOG4107RBB ABC transporter, permease G4G26_07655 ENOG4105E98 transcriptional regulator DeoR family G4G26_07660 ENOG4105DE4 1-phosphofructokinase G4G26_07665 ENOG4105DM4 PTS System G4G26_07670 ENOG4105C3F Signal peptidase i G4G26_07680 ENOG4105C5H ABC transporter G4G26_07685 ENOG41063V1 Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) G4G26_07710 ENOG4105BZU Histidine kinase G4G26_07720 ENOG4107ZYR domain protein G4G26_07730 ENOG4105CN5 Metallo-Beta-Lactamase G4G26_07740 ENOG4108X4Q Hydrolase G4G26_07745 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) G4G26_07765 ENOG4105CPP Dehydrogenase, E1 component G4G26_07770 ENOG4105C7S Dehydrogenase G4G26_07775 ENOG4107QN2 dihydrolipoyl dehydrogenase G4G26_07790 ENOG4105CXN decarboxylase G4G26_07795 ENOG4105WBI UPF0223 protein G4G26_07810 ENOG4105ECY inositol monophosphatase G4G26_07820 ENOG4105JQZ Methyltransferase G4G26_07860 ENOG4105CI3 gtp-binding protein typa G4G26_07865 ENOG4105QA2 G4G26_07880 ENOG4108IAB Phoh family G4G26_07890 ENOG4105CSV Glutaminase G4G26_07895 ENOG4105ZPI UPF0358 protein G4G26_07900 ENOG4105CNI cell division protein FtsW G4G26_07905 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) G4G26_07915 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) G4G26_07925 ENOG4105BZ9 Cytochrome C oxidase, subunit I G4G26_07930 ENOG4105CCU oxidase (Subunit III) G4G26_07935 ENOG41064X9 cytochrome C oxidase subunit IV G4G26_07950 ENOG41080XQ Signal transduction protein with cbs domains G4G26_07955 ENOG4106UY4 Inherit from COG: Scp-like extracellular G4G26_07975 ENOG4105WUC UPF0298 protein G4G26_07980 ENOG4106H78 methyltransferase G4G26_07985 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) G4G26_07990 ENOG4105H20 Sporulation integral membrane protein YlbJ G4G26_07995 ENOG4105D78 K07001 NTE family protein G4G26_08000 ENOG41063PX domain protein G4G26_08005 ENOG4105CDE UPF0348 protein G4G26_08015 ENOG4105KNH Nucleic acid-binding protein G4G26_08045 ENOG4108V6E Cell division protein mraZ G4G26_08050 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) G4G26_08060 ENOG4105CJN penicillin-binding protein G4G26_08065 ENOG4105CJN penicillin-binding protein G4G26_08070 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) G4G26_08075 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) G4G26_08080 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) G4G26_08085 ENOG4105CNI cell division protein FtsW G4G26_08090 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) G4G26_08095 ENOG4105D4A Cell wall formation (By similarity) G4G26_08100 ENOG4108W8M Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex (By similarity) G4G26_08105 ENOG4108R2U division initiation protein G4G26_08115 ENOG4105K67 small basic protein G4G26_08120 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) G4G26_08125 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) G4G26_08135 ENOG4105FFI sigma-e processing peptidase spoiiga G4G26_08140 ENOG4105DAV Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G4G26_08150 ENOG4105DKW ABC transporter G4G26_08160 ENOG4105WR5 sporulation protein, YlmC YmxH family G4G26_08165 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase G4G26_08170 ENOG4105DFA alanine racemase domain protein G4G26_08175 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) G4G26_08180 ENOG41067XK integral membrane protein G4G26_08185 ENOG4105DBK s4 domain protein G4G26_08195 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) G4G26_08205 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) G4G26_08210 ENOG4105C34 Pseudouridine synthase G4G26_08215 ENOG4108UK1 Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity) G4G26_08225 ENOG4105CXT aspartate transcarbamylase G4G26_08235 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain G4G26_08240 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain G4G26_08245 ENOG4105DF0 Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( ) (By similarity) G4G26_08250 ENOG4107RY0 Catalyzes the conversion of dihydroorotate to orotate (By similarity) G4G26_08255 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) G4G26_08260 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) G4G26_08265 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) G4G26_08275 ENOG4107S4M Sulfate adenylate transferase G4G26_08280 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) G4G26_08285 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) G4G26_08290 ENOG4105DAT cobalamin (vitamin b12) biosynthesis cbix protein G4G26_08295 ENOG41087GM Siroheme synthase (Precorrin-2 oxidase ferrochelatase domain)-like protein G4G26_08310 ENOG4105DSJ YicC domain protein G4G26_08315 ENOG4105KC4 UPF0296 protein G4G26_08320 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) G4G26_08330 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase G4G26_08335 ENOG4105C25 Primosomal protein n' G4G26_08340 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) G4G26_08345 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) G4G26_08350 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B G4G26_08355 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs G4G26_08360 ENOG4108ZF3 Phosphatase G4G26_08365 ENOG4105D9P serine threonine protein kinase G4G26_08370 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) G4G26_08375 ENOG4105DJV ribulose-phosphate 3-epimerase G4G26_08380 ENOG4105FJ0 thiamine G4G26_08390 ENOG4105VB9 50S ribosomal protein l28 G4G26_08395 ENOG4108ZAA Alkaline-shock protein G4G26_08400 ENOG4105DP4 dak2 domain fusion protein ylov G4G26_08410 ENOG4105EJQ L-serine dehydratase G4G26_08415 ENOG4105CB5 ATP-dependent DNA helicase recG G4G26_08420 ENOG4108VVV Transcriptional factor involved in regulation of membrane lipid biosynthesis by repressing genes involved in fatty acid and phospholipid metabolism (By similarity) G4G26_08430 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase G4G26_08435 ENOG4105CHR reductase G4G26_08445 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) G4G26_08450 ENOG4105CDB Required for chromosome condensation and partitioning (By similarity) G4G26_08455 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) G4G26_08465 ENOG4105VBN Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity) G4G26_08475 ENOG4105K5M 30s ribosomal protein S16 G4G26_08480 ENOG4108BW8 UPF0109 protein G4G26_08490 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) G4G26_08495 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) G4G26_08500 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) G4G26_08505 ENOG4105C9W Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity) G4G26_08510 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G4G26_08520 ENOG4105VM1 flagellar G4G26_08525 ENOG4105CMV Succinyl-CoA synthetase subunit beta G4G26_08530 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha G4G26_08535 ENOG4105C79 DNA protecting protein DprA G4G26_08540 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) G4G26_08545 ENOG4107QXI Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity) G4G26_08550 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G4G26_08555 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) G4G26_08560 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) G4G26_08570 ENOG4105Q75 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) G4G26_08575 ENOG4108ZC9 flagellar basal-body rod protein flgc G4G26_08580 ENOG4105VQ0 flagellar hook-basal body complex protein fliE G4G26_08585 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) G4G26_08590 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) G4G26_08605 ENOG4106YF4 Flagellar biosynthesis chaperone G4G26_08615 ENOG410696Y Flagellar hook-length control protein G4G26_08620 ENOG410822I Flagellar hook capping protein G4G26_08625 ENOG4108JQA flagellar G4G26_08630 ENOG41068WV flagellar FlbD family protein G4G26_08640 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) G4G26_08645 ENOG4105DD5 Flagellar motor switch protein G4G26_08650 ENOG4107YTP response regulator receiver protein G4G26_08660 ENOG4105CN7 Flagellar biosynthetic protein FliP G4G26_08665 ENOG4105VS8 Flagellar biosynthetic protein fliq G4G26_08670 ENOG4105D19 Role in flagellar biosynthesis (By similarity) G4G26_08675 ENOG4105D00 flagellar biosynthetic protein flhB G4G26_08680 ENOG4105D7B Flagellar biosynthesis protein flha G4G26_08685 ENOG4105FZW flagellar biosynthesis regulator FlhF G4G26_08695 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) G4G26_08700 ENOG4105CBS Chea signal transduction histidine kinase G4G26_08705 ENOG410807Z Modulation of CheA activity in response to attractants (Chemotaxis G4G26_08720 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G4G26_08730 ENOG4105CE9 30S ribosomal protein S2 G4G26_08735 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) G4G26_08745 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) G4G26_08750 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) G4G26_08755 ENOG4105KNE Phosphatidate cytidylyltransferase G4G26_08765 ENOG4105DZP Membrane-associated zinc metalloprotease G4G26_08770 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) G4G26_08775 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) G4G26_08780 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) G4G26_08785 ENOG4105CHV Transcription elongation factor NusA G4G26_08790 ENOG4105VZN Nucleic-acid-binding protein implicated in transcription termination G4G26_08795 ENOG4105VHM ribosomal protein G4G26_08800 ENOG4107EEM One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) G4G26_08805 ENOG4105W7A Protein of unknown function (DUF503) G4G26_08810 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) G4G26_08815 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) G4G26_08820 ENOG4105DTN riboflavin biosynthesis protein ribF G4G26_08825 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) G4G26_08830 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) G4G26_08840 ENOG4105C1V Peptidase, M16 G4G26_08850 ENOG4105E35 Dipicolinate synthase subunit A G4G26_08855 ENOG4108S0H Dipicolinic acid synthetase, b subunit G4G26_08860 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) G4G26_08870 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G4G26_08880 ENOG4105CVQ ATP-dependent Clp protease, proteolytic subunit G4G26_08890 ENOG4105CNU cell division protein FtsK G4G26_08895 ENOG4105FDP GntR family transcriptional regulator G4G26_08915 ENOG4108RKS Short-chain dehydrogenase reductase Sdr G4G26_08920 ENOG4105XZV Protein of unknown function (DUF3243) G4G26_08935 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase G4G26_08940 ENOG4105CEV competence damage-inducible protein G4G26_08950 ENOG4108A04 Beta-lactamase G4G26_08955 ENOG4105E4Y Endoribonuclease that initiates mRNA decay (By similarity) G4G26_08960 ENOG4105D48 metallophosphoesterase G4G26_08965 ENOG4105MCT stage V sporulation protein S G4G26_08975 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) G4G26_08980 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) G4G26_08995 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) G4G26_09000 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) G4G26_09010 ENOG4105IIP Membrane G4G26_09015 ENOG4105W1N transcriptional regulator G4G26_09020 ENOG4108151 Beta-lactamase domain protein G4G26_09030 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase G4G26_09040 ENOG4107QKG PfaD family G4G26_09045 ENOG41062T2 Acyl carrier protein G4G26_09050 ENOG4108MH3 Polyketide beta-ketoacyl acyl carrier protein synthase G4G26_09055 ENOG4105F99 Hydroxymethylglutaryl-CoA synthase G4G26_09060 ENOG4108MGH Enoyl-CoA hydratase G4G26_09065 ENOG4108KQ6 Enoyl-CoA hydratase G4G26_09070 ENOG4105C0W non-ribosomal peptide synthetase G4G26_09075 ENOG4107SQU synthase G4G26_09085 ENOG4105C0W non-ribosomal peptide synthetase G4G26_09095 ENOG4106A3M Cytochrome p-450 G4G26_09110 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin G4G26_09120 ENOG4105K7W phage-related replication protein G4G26_09125 ENOG4108X3M OsmC Ohr family protein G4G26_09130 ENOG410814C multidrug resistance protein G4G26_09150 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) G4G26_09155 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) G4G26_09170 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) G4G26_09175 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G4G26_09180 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G4G26_09185 ENOG4105U6W MutT NUDIX family protein G4G26_09190 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase G4G26_09195 ENOG4106F1P AAA ATPase, central domain protein G4G26_09200 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) G4G26_09205 ENOG4105CXI aluminum resistance protein G4G26_09210 ENOG4105KV4 Transcriptional regulator G4G26_09215 ENOG4105C5F glutamine synthetase G4G26_09400 ENOG4108FKH Transglycosylase SLT domain G4G26_09410 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj G4G26_09420 ENOG41068G1 G4G26_09445 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase G4G26_09450 ENOG4106ANW SMI1_KNR4 G4G26_09455 ENOG4106BHF G4G26_09460 ENOG410780I phosphoprotein phosphatase activity G4G26_09470 ENOG41079P0 G4G26_09500 ENOG4106WTF Glycosyl transferase, family 2 G4G26_09505 ENOG4107RGC Glycosyl transferase, family 2 G4G26_09535 ENOG4107NTZ G4G26_09550 ENOG410907G G4G26_09565 ENOG4105CT4 transporter G4G26_09570 ENOG4105DSG hydrolase family 43 G4G26_09575 ENOG4105E2R ROK family G4G26_09580 ENOG4105C93 Xylose Isomerase G4G26_09585 ENOG4105CMG Carbohydrate kinase G4G26_09595 ENOG4107Y9E nuclease G4G26_09600 ENOG4105C54 Major Facilitator superfamily G4G26_09605 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) G4G26_09615 ENOG4107YUK This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) G4G26_09680 ENOG4108Q8B Spore germination protein G4G26_09685 ENOG4108NHD germination protein G4G26_09700 ENOG4105FVX G4G26_09710 ENOG4105K7W phage-related replication protein G4G26_09725 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) G4G26_09735 ENOG4108SVB resolvase G4G26_09740 ENOG4105VPS UPF0291 protein G4G26_09745 ENOG4105CV1 Transketolase (EC 2.2.1.1) G4G26_09765 ENOG4107QIV Cytochrome c biogenesis protein G4G26_09790 ENOG4107DZX Small, acid-soluble spore protein P G4G26_09800 ENOG4108I0Z Aconitate hydratase G4G26_09805 ENOG4107QXG alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G4G26_09820 ENOG41067CD Small, acid-soluble spore protein Tlp G4G26_09830 ENOG4105MI2 G4G26_09835 ENOG4105W8X HesB YadR YfhF-family protein G4G26_09840 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) G4G26_09845 ENOG4105K4P CoA-binding domain protein G4G26_09850 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G4G26_09870 ENOG4107QWR cellulase (EC 3.2.1.4) G4G26_09880 ENOG4108MYR Secreted protein G4G26_09885 ENOG4107SYN Glycosyl hydrolases family 43 G4G26_09895 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G4G26_09900 ENOG4107T5V SNARE associated Golgi G4G26_09910 ENOG4107QX3 carboxylase G4G26_09915 ENOG4105E39 Enoyl-CoA hydratase G4G26_09920 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase G4G26_09925 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit G4G26_09930 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G4G26_09935 ENOG4105CEY Amp-dependent synthetase and ligase G4G26_09940 ENOG4105C1G acyl-Coa dehydrogenase G4G26_09955 ENOG4105F32 YngK protein G4G26_09960 ENOG4106U2H Protein of unknown function (DUF1360) G4G26_09970 ENOG4105CEY Amp-dependent synthetase and ligase G4G26_09975 ENOG4105C0W non-ribosomal peptide synthetase G4G26_09985 ENOG4105C0W non-ribosomal peptide synthetase G4G26_09990 ENOG4107RVU D-Ala-D-Ala carboxypeptidase 3 (S13) family G4G26_09995 ENOG4108N2V aldose 1-epimerase G4G26_10000 ENOG4107QJQ Mate efflux family protein G4G26_10025 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G4G26_10030 ENOG4105SKE transcriptional Regulator LysR family G4G26_10035 ENOG4105CB2 alcohol dehydrogenase G4G26_10040 ENOG4105BZ8 glutamate synthase G4G26_10045 ENOG4105CBC glutamate synthase G4G26_10050 ENOG4105C5Q Transcriptional regulator G4G26_10055 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) G4G26_10060 ENOG4105II7 pyrroline-5-carboxylate reductase G4G26_10080 ENOG4108UB7 G4G26_10090 ENOG4105IE8 Alpha-ketoglutarate permease G4G26_10095 ENOG4107U6E carbohydrate kinase FGGY G4G26_10100 ENOG4108M3J Dehydrogenase G4G26_10105 ENOG4108J2R molybdopterin oxidoreductase G4G26_10135 ENOG4105EC8 Methyl-accepting chemotaxis G4G26_10145 ENOG4108YQE rare lipoprotein a G4G26_10150 ENOG4105XPP Protein of unknown function (DUF1275) G4G26_10155 ENOG4108NR7 pectate lyase G4G26_10160 ENOG4108RAV Conserved protein G4G26_10170 ENOG4105F0F Oxalate decarboxylase G4G26_10180 ENOG4105EPI acetyltransferase, (GNAT) family G4G26_10200 ENOG41073R8 VanW family G4G26_10210 ENOG4105VMP Transcriptional regulator G4G26_10215 ENOG4105NX3 Membrane G4G26_10225 ENOG4108Q5Y Membrane G4G26_10235 ENOG4108V4B ThiJ pfpI G4G26_10240 ENOG4108J4B Beta-lactamase G4G26_10260 ENOG4107R95 Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) G4G26_10265 ENOG4107T94 Endo-14-beta-xylanase G4G26_10270 ENOG4105YB8 TM2 domain containing protein G4G26_10315 ENOG4108Z7R Chaperone CsaA G4G26_10320 ENOG4105FTV AraC Family Transcriptional Regulator G4G26_10325 ENOG4108HJF gCN5-related N-acetyltransferase G4G26_10335 ENOG4108W8B Beta-lactamase domain protein G4G26_10345 ENOG4105D29 Helix-turn-helix type 11 domain protein G4G26_10355 ENOG4105KTU Transcriptional regulator, arsr family G4G26_10365 ENOG4108SJC Membrane G4G26_10385 ENOG4105ECK Fatty Acid Desaturase G4G26_10390 ENOG4108ZGX Histidine kinase G4G26_10395 ENOG4108S01 response regulator G4G26_10400 ENOG41069ER domain protein G4G26_10405 ENOG4105C9U ATP-dependent DNA helicase RecQ G4G26_10415 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) G4G26_10420 ENOG4105SCY DNAK suppressor G4G26_10460 ENOG4105C26 Dehydrogenase G4G26_10465 ENOG4105EWU Squalene--hopene cyclase G4G26_10470 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G4G26_10475 ENOG4105C8J )-transporter G4G26_10480 ENOG4105C09 Bile acid G4G26_10485 ENOG4105C7S Dehydrogenase G4G26_10495 ENOG4107T89 von Willebrand factor, type A G4G26_10500 ENOG4105GMT ATPase associated with various cellular activities aaa_5 G4G26_10510 ENOG4105K4H Nlp p60 protein G4G26_10515 ENOG41087PP glycosyltransferase MGT family G4G26_10525 ENOG4107QMU Mate efflux family protein G4G26_10530 ENOG4106SCS STAS domain G4G26_10550 ENOG4105FR1 rard protein G4G26_10565 ENOG4105C6Z Gluconate G4G26_10570 ENOG41090U3 tautomerase G4G26_10585 ENOG4105FBA Phospholipase Carboxylesterase G4G26_10600 ENOG4105E1V na solute symporter G4G26_10620 ENOG4108VXD carboxy-peptidase G4G26_10625 ENOG4105D3A purine nucleoside phosphorylase DeoD-type G4G26_10635 ENOG4106Z5R G4G26_10640 ENOG410841Q phosphoesterase PA-phosphatase related protein G4G26_10670 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein G4G26_10675 ENOG4108TSC N-acetyltransferase G4G26_10680 ENOG4107S4Y M20 DapE family protein YgeY G4G26_10695 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G4G26_10735 ENOG4107T32 3-phytase (EC 3.1.3.8) G4G26_10740 ENOG4105C5E polysaccharide biosynthesis protein G4G26_10745 ENOG4105E0X reductase G4G26_10750 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) G4G26_10770 ENOG4105QZP Uncharacterized protein conserved in bacteria (DUF2140) G4G26_10775 ENOG41090WU lipolytic protein G-D-S-L family G4G26_10780 ENOG4108KF3 Electron transport protein SCO1 SenC G4G26_10790 ENOG4105C7B Threonine dehydratase G4G26_10800 ENOG4108UT2 hemolysin iii G4G26_10810 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) G4G26_10815 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) G4G26_10830 ENOG4107YX5 Pfam:DUF548 G4G26_10835 ENOG4108Y6J UPF0403 protein G4G26_10840 ENOG4105C01 Dihydroxy-acid dehydratase G4G26_10855 ENOG4108V06 Glutathione peroxidase G4G26_10860 ENOG4105CVG Homoserine O-transsuccinylase G4G26_10905 ENOG41081VK Ribonuclease G4G26_10930 ENOG410890F Dynamin family G4G26_10945 ENOG41065KQ synthase G4G26_10950 ENOG4105C2W permease G4G26_10955 ENOG4108UPS Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis (By similarity) G4G26_10960 ENOG4105CTD carboxy-peptidase G4G26_10965 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) G4G26_10970 ENOG4108UHU Aldolase G4G26_10975 ENOG4105D7K pfkb domain protein G4G26_10980 ENOG4108M60 Transcriptional regulator G4G26_10990 ENOG4105CHR reductase G4G26_10995 ENOG4105DVT helicase G4G26_11010 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) G4G26_11025 ENOG4108UKS UPF0398 protein G4G26_11040 ENOG4107X2U Inherit from COG: Exonuclease-like protein G4G26_11045 ENOG4108I5C dEAD DEAH box helicase G4G26_11095 ENOG4105BZ4 penicillin-binding protein G4G26_11105 ENOG4105CSM endonuclease III G4G26_11115 ENOG4105C5S asparaginyl-tRNA synthetase G4G26_11120 ENOG4105CHM Aminotransferase G4G26_11130 ENOG4105YAC G4G26_11135 ENOG4105DVT helicase G4G26_11140 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) G4G26_11145 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) G4G26_11150 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) G4G26_11155 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase G4G26_11160 ENOG4105DJ0 Poly(A) Polymerase G4G26_11165 ENOG4105CPK Glycosyl transferase (Group 1 G4G26_11170 ENOG4105FJR Lmbe family G4G26_11175 ENOG4108Z5K methylglyoxal synthase G4G26_11180 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) G4G26_11185 ENOG4108ZPQ MazG nucleotide pyrophosphohydrolase G4G26_11190 ENOG4108JYZ YitT family G4G26_11210 ENOG4105DJ5 Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity) G4G26_11230 ENOG41068YB TPR repeat-containing protein G4G26_11235 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase G4G26_11245 ENOG4105CIH Imidazole acetol-phosphate transaminase G4G26_11255 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) G4G26_11260 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase G4G26_11270 ENOG4108I0Q anthranilate phosphoribosyltransferase G4G26_11275 ENOG4105CRQ synthase (Component I) G4G26_11280 ENOG4105KHN chorismate mutase G4G26_11285 ENOG4105D49 3-dehydroquinate synthase G4G26_11290 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase G4G26_11295 ENOG4105BZU Histidine kinase G4G26_11300 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) G4G26_11305 ENOG4105EAH synthase G4G26_11310 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) G4G26_11315 ENOG4105XXQ heptaprenyl diphosphate synthase component I G4G26_11325 ENOG4105EUJ GTP cyclohydrolase i G4G26_11330 ENOG4105K70 DNA-binding protein G4G26_11335 ENOG4105DXU ATPase. Has a role at an early stage in the morphogenesis of the spore coat (By similarity) G4G26_11350 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase G4G26_11355 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) G4G26_11360 ENOG41065D1 G4G26_11365 ENOG4105S2F G4G26_11380 ENOG4106UJV Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) G4G26_11385 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) G4G26_11390 ENOG4105CAT Cytidine monophosphate kinase G4G26_11405 ENOG4105MSI germination protein ypeb G4G26_11415 ENOG4108PNU Involved in the degradation of specific anti-sigma factors (By similarity) G4G26_11420 ENOG4105E4T pyridine nucleotide-disulfide oxidoreductase G4G26_11435 ENOG4107RGJ metallophosphoesterase G4G26_11450 ENOG4105I7S Abortive infection protein G4G26_11455 ENOG4105C9U ATP-dependent DNA helicase RecQ G4G26_11460 ENOG4105T7X G4G26_11470 ENOG4108SAX Membrane G4G26_11475 ENOG4108JQ1 Dehydrogenase G4G26_11480 ENOG4105FF2 Type I DHQase G4G26_11495 ENOG4105BZU Histidine kinase G4G26_11500 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G4G26_11505 ENOG4105CRE cytochrome C G4G26_11510 ENOG4107TWT Cytochrome c biogenesis protein G4G26_11520 ENOG4105FE9 pseudouridine synthase G4G26_11530 ENOG4108JIC nucleoside recognition domain protein G4G26_11535 ENOG4105DZ1 carboxypeptidase G4G26_11545 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) G4G26_11550 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) G4G26_11565 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) G4G26_11570 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) G4G26_11575 ENOG4108R6K riboflavin synthase, subunit alpha G4G26_11580 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) G4G26_11590 ENOG4105C3F Signal peptidase i G4G26_11600 ENOG4105VES Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) G4G26_11635 ENOG4107ZE5 PPIases accelerate the folding of proteins G4G26_11640 ENOG4105PTM secreted protein G4G26_11645 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) G4G26_11655 ENOG4105G6R Stage v sporulation protein ae G4G26_11665 ENOG4105CZ3 stage V sporulation protein ad G4G26_11670 ENOG41090VF Stage v sporulation protein ac G4G26_11685 ENOG4105CT2 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G4G26_11690 ENOG4108ZBE Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition (By similarity) G4G26_11695 ENOG41082AN stage II sporulation protein G4G26_11700 ENOG4105DZ1 carboxypeptidase G4G26_11705 ENOG4105CB1 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) G4G26_11710 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) G4G26_11715 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G4G26_11725 ENOG4105I3K Ferric uptake regulator, Fur family G4G26_11730 ENOG4105MZ9 stage II sporulation protein m G4G26_11745 ENOG4105DFD Na H antiporter G4G26_11750 ENOG4108IJ0 Aspartate ammonia-lyase G4G26_11755 ENOG4105HDK L-asparaginase G4G26_11760 ENOG4108IMY Transcriptional regulator G4G26_11770 ENOG4108YZ4 nudix hydrolase G4G26_11780 ENOG4105CPC Aldo Keto reductase G4G26_11800 ENOG4106HZJ G4G26_11805 ENOG4105RHY Pfam:UPF0157 G4G26_11810 ENOG4105KAC Antibiotic biosynthesis monooxygenase G4G26_11815 ENOG4108XET gCN5-related N-acetyltransferase G4G26_11825 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G4G26_11835 ENOG4105E5W Transporter G4G26_11845 ENOG4105HRU Glyoxalase Bleomycin resistance protein (Dioxygenase G4G26_11860 ENOG4108IXY short-chain dehydrogenase reductase G4G26_11865 ENOG41069FQ Metallo-beta-lactamase superfamily G4G26_11870 ENOG4105II7 pyrroline-5-carboxylate reductase G4G26_11880 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G4G26_11890 ENOG410861F 50S ribosomal protein L33 G4G26_11895 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) G4G26_11900 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase G4G26_11905 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) G4G26_11910 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G4G26_11920 ENOG4107XQC Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity) G4G26_11925 ENOG4108NA0 Uncharacterized conserved protein (COG2071) G4G26_11930 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) G4G26_11935 ENOG4108HNZ carboxyl transferase G4G26_11940 ENOG4108ZVT methylmalonyl-coA epimerase G4G26_11950 ENOG4108VZI ErfK ybiS ycfS ynhG family protein G4G26_11955 ENOG4108QEG Membrane G4G26_11960 ENOG4105CDA abc transporter atp-binding protein G4G26_11965 ENOG4105E5Q amino acid AbC transporter G4G26_11970 ENOG4108HW3 (ABC) transporter G4G26_11975 ENOG4108Y6J UPF0403 protein G4G26_11980 ENOG4109050 May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG) G4G26_11995 ENOG4105C7S Dehydrogenase G4G26_12000 ENOG4105CPP Dehydrogenase, E1 component G4G26_12015 ENOG4105CKM Branched-chain carboxylic acid kinase G4G26_12020 ENOG4107RDP Dehydrogenase G4G26_12030 ENOG4108JUB Transcriptional regulator G4G26_12035 ENOG4106CCJ Protein of unknown function (DUF2627) G4G26_12040 ENOG4105CR4 methylisocitrate lyase G4G26_12045 ENOG4105DXD 2-methylcitrate dehydratase G4G26_12055 ENOG4105C1G acyl-Coa dehydrogenase G4G26_12060 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G4G26_12070 ENOG4108QXE glycerophosphoryl diester phosphodiesterase G4G26_12075 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase G4G26_12090 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G4G26_12095 ENOG4107QQR Sporulation G4G26_12100 ENOG4105S1Z Stage IV sporulation protein B G4G26_12105 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) G4G26_12110 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) G4G26_12115 ENOG4105DX0 Hemolysin A G4G26_12125 ENOG4105CTB Polyprenyl synthetase G4G26_12130 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G4G26_12135 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G4G26_12140 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) G4G26_12145 ENOG4105M7K Involved in the transcription termination process (By similarity) G4G26_12150 ENOG4108ZSR alkaline shock protein G4G26_12155 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G4G26_12175 ENOG410644B Stage III sporulation protein af G4G26_12185 ENOG4105KQ4 Stage iii sporulation protein ad G4G26_12190 ENOG4108CQH stage III sporulation protein AC G4G26_12195 ENOG4105KR5 Stage iii sporulation protein G4G26_12200 ENOG4105CD2 stage iii sporulation protein aa G4G26_12210 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) G4G26_12215 ENOG4105DC7 peptidase M24 G4G26_12220 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) G4G26_12230 ENOG4105CBJ Metal-dependent enzyme G4G26_12245 ENOG4105KST dependent repressor G4G26_12250 ENOG4107S5Z Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domain of GcvH, an intermediate carrier during protein lipoylation (By similarity) G4G26_12255 ENOG4105WZW rhodanese family G4G26_12260 ENOG4107RGW The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor G4G26_12265 ENOG4107QK8 The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor G4G26_12270 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) G4G26_12275 ENOG4105C0D helicase G4G26_12290 ENOG4108IMY Transcriptional regulator G4G26_12300 ENOG4105VFR signal peptidase G4G26_12355 ENOG41080XP Cbs domain G4G26_12365 ENOG4105C37 (CBS) domain G4G26_12390 ENOG4105C5X domain protein G4G26_12415 ENOG4105E0M Sulfatase G4G26_12430 ENOG4107ZXI Rhomboid family G4G26_12440 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase G4G26_12465 ENOG41068DG YceG-like family G4G26_12470 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) G4G26_12475 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) G4G26_12480 ENOG4105E2Z phosphate ABC transporter (Permease G4G26_12485 ENOG4105C8U phosphate abc transporter G4G26_12490 ENOG4105CVA phosphate G4G26_12495 ENOG4107RF6 penicillin-binding protein G4G26_12505 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G4G26_12510 ENOG4105SXS Protein of unknown function (DUF456) G4G26_12525 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) G4G26_12530 ENOG41063Y9 G4G26_12535 ENOG4108U5J '-nucleotidase G4G26_12540 ENOG4105N80 Ferric uptake regulator, Fur family G4G26_12545 ENOG4108JYZ YitT family G4G26_12550 ENOG41069ZM Protein of unknown function (DUF2624) G4G26_12555 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) G4G26_12570 ENOG4108IUH Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) G4G26_12575 ENOG4105EGD dinuclear metal center protein, YbgI family G4G26_12590 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G4G26_12595 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) G4G26_12600 ENOG41082VT Uncharacterized BCR, YaiI/YqxD family COG1671 G4G26_12605 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) G4G26_12615 ENOG4105C38 Glycyl-tRNA synthetase beta subunit G4G26_12620 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit G4G26_12625 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) G4G26_12635 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) G4G26_12640 ENOG4105KG3 cytidine deaminase G4G26_12645 ENOG4107YR5 Diacylglycerol kinase G4G26_12650 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) G4G26_12655 ENOG4105CTJ Metal Dependent Phosphohydrolase G4G26_12660 ENOG4105C9A Phoh family G4G26_12665 ENOG4105EI1 sporulation protein yqfd G4G26_12670 ENOG41068P3 sporulation protein YqfC G4G26_12680 ENOG4105DI5 UPF0365 protein G4G26_12685 ENOG4105F7J membrane-bound serine protease G4G26_12690 ENOG4105KTH gatB Yqey G4G26_12705 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) G4G26_12710 ENOG4107TVK Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) G4G26_12715 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) G4G26_12725 ENOG4105CFG Acts as a chaperone (By similarity) G4G26_12730 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ G4G26_12735 ENOG4105CI8 Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity) G4G26_12740 ENOG4105CSA Coproporphyrinogen iii oxidase G4G26_12745 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) G4G26_12755 ENOG4108ZRV stage ii sporulation protein p G4G26_12760 ENOG4105CEF Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity) G4G26_12765 ENOG41082YS Binds directly to 16S ribosomal RNA G4G26_12770 ENOG4105TQK DNA polymerase iii, delta' subunit G4G26_12785 ENOG4105EGY DNA internalization-related competence protein ComEC Rec2 G4G26_12790 ENOG4108UK2 deaminase G4G26_12795 ENOG4105KQC Competence protein G4G26_12805 ENOG4108D32 Methyltransferase G4G26_12815 ENOG4108WF2 Metal Dependent Phosphohydrolase G4G26_12820 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) G4G26_12825 ENOG410812S Rna-binding protein G4G26_12830 ENOG4105E2X shikimate dehydrogenase G4G26_12835 ENOG4105CQW ribosome biogenesis GTPase YqeH G4G26_12840 ENOG4108WJV had superfamily (subfamily IIIa) phosphatase G4G26_12855 ENOG4108VPC n-acetylmuramoyl-l-alanine amidase G4G26_12860 ENOG41080BT SNARE associated Golgi G4G26_12875 ENOG4105WFK nuclease G4G26_12885 ENOG4107Y5K Resolvase G4G26_12890 ENOG4108UXE Protein tyrosine phosphatase G4G26_12895 ENOG4105D6J arsenicaL-resistance protein G4G26_12900 ENOG4108YZ3 Glyoxalase Bleomycin resistance protein (Dioxygenase G4G26_12905 ENOG41085FC arsR family transcriptional regulator G4G26_12975 ENOG41064HX Suppressor of fused protein (SUFU) G4G26_12995 ENOG4105T4X n-acetylmuramoyl-l-alanine amidase G4G26_13030 ENOG410906S phage-like element pbsx protein xkdt G4G26_13035 ENOG41066EA baseplate J family protein G4G26_13040 ENOG4105MFU Protein of unknown function (DUF2634) G4G26_13050 ENOG4105X7F G4G26_13060 ENOG4108FKH Transglycosylase SLT domain G4G26_13070 ENOG4105MTC XkdN-like protein G4G26_13080 ENOG4105FR7 XkdM protein, phage-like element PBSX G4G26_13085 ENOG4105PQS phage protein G4G26_13100 ENOG41060SN G4G26_13135 ENOG4106CGH Phage Mu protein F like protein G4G26_13140 ENOG4108MDF Phage Portal Protein G4G26_13145 ENOG4105IG6 Phage terminase, large subunit G4G26_13175 ENOG4105QBX endodeoxyribonuclease RusA G4G26_13195 ENOG4108PNI recT protein G4G26_13200 ENOG4108NF7 phage-type endonuclease G4G26_13230 ENOG4106A7E Transcriptional regulator G4G26_13235 ENOG41067QW Transcriptional regulator G4G26_13245 ENOG4105KR8 Inherit from COG: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) G4G26_13270 ENOG4105D3P Mannan endo-1,4-beta-mannosidase G4G26_13275 ENOG41087NI Sulfite exporter TauE/SafE G4G26_13280 ENOG4105VFE sira family G4G26_13285 ENOG4107TPS domain protein G4G26_13295 ENOG4105VFE sira family G4G26_13300 ENOG4105HF9 Inherit from COG: pyridine nucleotide-disulfide oxidoreductase G4G26_13305 ENOG4105XTG Pfam:DUF156 G4G26_13310 ENOG4108VK3 Cupin 2 Conserved Barrel Domain Protein G4G26_13320 ENOG41090E6 transcriptional regulator MERR family G4G26_13335 ENOG4105C37 (CBS) domain G4G26_13350 ENOG410825D TRANSCRIPTIONal REGULATOR, LysR family G4G26_13355 ENOG4105H3G oxidoreductase G4G26_13360 ENOG4105PGM cation diffusion facilitator family transporter G4G26_13375 ENOG4105KMT branched-chain amino acid G4G26_13380 ENOG4108UMN azlc family G4G26_13385 ENOG4108ZRZ Transcriptional regulator (AsnC family) G4G26_13405 ENOG41064BW Protein of unknown function (DUF2568) G4G26_13420 ENOG41075D4 Aminoglycoside 6-adenylyltransferase G4G26_13425 ENOG4105EA8 2-Nitropropane dioxygenase G4G26_13435 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) G4G26_13445 ENOG4107YCY Transcriptional regulator G4G26_13465 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) G4G26_13470 ENOG4108HHA Transketolase G4G26_13485 ENOG4105UNS Pfam:DUF419 G4G26_13495 ENOG4108MEK Metal-binding protein YodA G4G26_13500 ENOG410904A RNA polymerase G4G26_13505 ENOG4105CPC Aldo Keto reductase G4G26_13515 ENOG4108KAM Transcriptional regulator G4G26_13520 ENOG4105C7F AcnD-accessory protein PrpF G4G26_13525 ENOG41083Q9 chitosanase G4G26_13530 ENOG4105X5K response regulator receiver protein G4G26_13535 ENOG4108VQT Alpha beta hydrolase fold protein G4G26_13540 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein G4G26_13545 ENOG4106H77 Inherit from COG: SH3 type 3 domain-containing protein G4G26_13555 ENOG4105Z0X Glyoxalase Bleomycin resistance protein (Dioxygenase G4G26_13565 ENOG4105PGS Spore coat protein G4G26_13570 ENOG4105E2A Dehydrogenase G4G26_13585 ENOG4105VUF Transcriptional regulator G4G26_13595 ENOG4105DQ4 alcohol dehydrogenase G4G26_13600 ENOG4108Z0Z intracellular protease Pfpi family G4G26_13605 ENOG4108HKT sucrose-6-phosphate hydrolase G4G26_13610 ENOG4105F3R pts system mannose fructose sorbose family iid G4G26_13615 ENOG4105ETZ PTS System G4G26_13620 ENOG4108IQ3 PTS system G4G26_13625 ENOG4105YHU PTS system G4G26_13630 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G4G26_13640 ENOG4105C85 amino acid G4G26_13645 ENOG4105N14 lysine exporter protein LysE YggA G4G26_13650 ENOG4108NGU Transcriptional regulator G4G26_13655 ENOG4105JVQ RNA Polymerase G4G26_13660 ENOG4108P49 AntiSigma factor G4G26_13665 ENOG4105EXC Acyl-transferase G4G26_13670 ENOG4105WDR G4G26_13675 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G4G26_13680 ENOG41082JN Transcriptional regulator G4G26_13700 ENOG4105TMB Formate nitrite transporter G4G26_13705 ENOG4108ZSU Uncharacterized conserved protein (DUF2294) G4G26_13710 ENOG4108JB9 formate dehydrogenase G4G26_13725 ENOG4105C28 cystathionine G4G26_13740 ENOG4108WVK Could be a S-adenosyl-L-methionine-dependent methyltransferase (By similarity) G4G26_13755 ENOG4107XRG penicillin-binding protein G4G26_13760 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) G4G26_13765 ENOG4105DBI uridine monophosphokinase G4G26_13770 ENOG4105CFP Peptidase U32 G4G26_13775 ENOG4105XYU peptidase (U32 family) G4G26_13785 ENOG4105HHA aminodeoxychorismate lyase G4G26_13790 ENOG4105VPH UPF0473 protein G4G26_13795 ENOG4108Z08 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) G4G26_13800 ENOG4105VBH UPF0297 protein G4G26_13805 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) G4G26_13810 ENOG4105C02 permease G4G26_13815 ENOG4105CDA abc transporter atp-binding protein G4G26_13820 ENOG4105CT1 (ABC) transporter G4G26_13825 ENOG4105EAD ABC transporter G4G26_13830 ENOG4105DRP amino acid AbC transporter G4G26_13840 ENOG41060CR G4G26_13850 ENOG4105C7H Helicase, RecD TraA family G4G26_13860 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) G4G26_13865 ENOG4105C3J Cysteine desulfurase G4G26_13875 ENOG4105D1H recombination factor protein RarA G4G26_13880 ENOG4105CUZ uba thif-type nad fad binding protein G4G26_13890 ENOG4105C9M aspartyl-trna synthetase G4G26_13895 ENOG4105CUT histidyl-tRNA synthetase G4G26_13905 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase G4G26_13915 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G4G26_13920 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) G4G26_13925 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) G4G26_13930 ENOG41067VP Protein of unknown function (DUF1049) G4G26_13935 ENOG4105NCW Trka-c domain protein G4G26_13940 ENOG4105C3D Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G4G26_13950 ENOG4105CKP Polysaccharide Biosynthesis Protein G4G26_13955 ENOG4108QG2 Membrane G4G26_13960 ENOG4105NAP G4G26_13965 ENOG4105VIE preprotein translocase, subunit YajC G4G26_13970 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) G4G26_13975 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) G4G26_13980 ENOG41061AI Protein of unknown function (DUF2905) G4G26_13985 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) G4G26_13990 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) G4G26_14000 ENOG4105IE8 Alpha-ketoglutarate permease G4G26_14005 ENOG4105CK5 oxidoreductase G4G26_14030 ENOG4105BZG amino acid carrier protein G4G26_14035 ENOG4105CDY transcriptional regulatory protein G4G26_14045 ENOG4106678 morphogenetic protein associated with SpoVID G4G26_14050 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) G4G26_14055 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase G4G26_14060 ENOG4108IYU L-aspartate oxidase G4G26_14075 ENOG4105CQC Prephenate dehydratase G4G26_14080 ENOG41090I5 UPF0735 ACT domain-containing protein G4G26_14085 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control G4G26_14100 ENOG4105K46 50S ribosomal protein l27 G4G26_14105 ENOG4105X36 (ribosomal) protein G4G26_14110 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) G4G26_14125 ENOG4107QMS site-determining protein G4G26_14130 ENOG4107YDG Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) G4G26_14135 ENOG4105YHC Rod shape-determining protein MreD G4G26_14145 ENOG4105DFF Rod shape-determining protein mreb G4G26_14150 ENOG4105W5Q DNA repair protein (RadC G4G26_14155 ENOG4108Z03 MAF-like protein G4G26_14165 ENOG4106A3R peptidase G4G26_14170 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase G4G26_14175 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) G4G26_14185 ENOG4106AR7 Spore coat protein G4G26_14190 ENOG41068KH stage VI sporulation protein D G4G26_14195 ENOG4105CDM Glutamate-1-semialdehyde aminotransferase G4G26_14200 ENOG4105D52 delta-aminolevulinic acid dehydratase G4G26_14210 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) G4G26_14220 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) G4G26_14230 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) G4G26_14235 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) G4G26_14240 ENOG4108IUQ atp-dependent protease G4G26_14245 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) G4G26_14250 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation G4G26_14260 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G4G26_14265 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) G4G26_14270 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G4G26_14275 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) G4G26_14280 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase G4G26_14285 ENOG4108ZP8 Acetolactate synthase small subunit G4G26_14290 ENOG4105C7K acetolactate synthase G4G26_14300 ENOG4105I4A GCN5-related N-acetyltransferase G4G26_14305 ENOG4107KM7 Heat induced stress protein YflT G4G26_14315 ENOG4105M59 Phosphodiesterase, mj0936 family G4G26_14320 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) G4G26_14325 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) G4G26_14330 ENOG4108XJQ germination protein G4G26_14335 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) G4G26_14340 ENOG41067TZ transcriptional regulator, MarR family G4G26_14345 ENOG4105PFC Transcriptional regulator G4G26_14355 ENOG4105E33 succinate dehydrogenase G4G26_14365 ENOG4108NU2 Succinate dehydrogenase cytochrome b558 subunit G4G26_14375 ENOG4105CFH Aspartokinase G4G26_14380 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) G4G26_14385 ENOG4105K63 Thioredoxin G4G26_14390 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) G4G26_14395 ENOG4105C10 Electron transfer flavoprotein G4G26_14400 ENOG4105BZJ Electron transfer flavoprotein G4G26_14405 ENOG41060WC Enoyl-CoA hydratase G4G26_14410 ENOG4107Z3H Transcriptional regulator, TetR family G4G26_14415 ENOG4105CEY Amp-dependent synthetase and ligase G4G26_14425 ENOG4105C98 muts2 protein G4G26_14430 ENOG4105DCG PHP domain protein G4G26_14445 ENOG4107FSS Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G4G26_14450 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) G4G26_14455 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) G4G26_14465 ENOG4108RWN rrna methyltransferase G4G26_14470 ENOG41067MF small acid-soluble spore protein G4G26_14480 ENOG4105CQB FAD linked oxidase domain protein G4G26_14485 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) G4G26_14505 ENOG4105CZZ Alpha-N-arabinofuranosidase (EC 3.2.1.55) G4G26_14510 ENOG4105DRS transport system, permease G4G26_14525 ENOG4108MDK Dehydrogenase G4G26_14535 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase G4G26_14540 ENOG4105EF1 ribulokinase G4G26_14550 ENOG4107PMW Arabinan endo-1,5-alpha-L-arabinosidase G4G26_14555 ENOG4105CN9 Peptidase m42 family protein G4G26_14565 ENOG410696E Membrane G4G26_14570 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) G4G26_14575 ENOG4105VJV 50s ribosomal protein L35 G4G26_14580 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) G4G26_14590 ENOG41067MG lrgb family G4G26_14600 ENOG4105DY9 regulatoR G4G26_14605 ENOG4108HRK Histidine kinase G4G26_14615 ENOG4105C22 threonyL-tRNA synthetase G4G26_14620 ENOG4108TDW sporulation protein YtxC G4G26_14640 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) G4G26_14645 ENOG4105X3E Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) G4G26_14650 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G4G26_14655 ENOG4105KVH Transcriptional regulator G4G26_14660 ENOG4105F27 Major Facilitator G4G26_14665 ENOG4105CV8 reductase G4G26_14670 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) G4G26_14680 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) G4G26_14685 ENOG4105C2M dna polymerase I G4G26_14690 ENOG4105BZU Histidine kinase G4G26_14695 ENOG4105DPZ Two component transcriptional regulator (Winged helix family G4G26_14700 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) G4G26_14705 ENOG4108HMX isocitrate dehydrogenase (NADP) G4G26_14710 ENOG4105BZN citrate synthase G4G26_14720 ENOG4108REF Sporulation integral membrane protein ytvi G4G26_14725 ENOG4105FS0 cytoplasmic membrane protein G4G26_14730 ENOG4105CA9 Pyruvate kinase G4G26_14735 ENOG4105CTQ phosphohexokinase G4G26_14745 ENOG4108IEY Carboxyl transferase domain G4G26_14750 ENOG4105C6K Malic enzyme G4G26_14755 ENOG4105C0B DNA polymerase III (alpha subunit) G4G26_14760 ENOG4105VV2 G4G26_14770 ENOG4106EVM G4G26_14775 ENOG4105SFS phosphoesterase RecJ domain protein G4G26_14790 ENOG4105E8R UPF0173 metal-dependent hydrolase G4G26_14805 ENOG4105CH7 arginosuccinase G4G26_14810 ENOG4105CDH Citrulline--aspartate ligase G4G26_14815 ENOG4105EPU Molybdenum cofactor synthesis domain protein G4G26_14820 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) G4G26_14835 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) G4G26_14840 ENOG4105KBJ sporulation protein ytfj G4G26_14850 ENOG4105VK3 rdd domain containing protein G4G26_14855 ENOG4105D07 Signal peptide peptidase, SppA G4G26_14860 ENOG4108KKH Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) G4G26_14865 ENOG4105EFZ amidohydrolase G4G26_14870 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G4G26_14905 ENOG4105U5Y Transcriptional regulator G4G26_14915 ENOG4105BZU Histidine kinase G4G26_14925 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) G4G26_14930 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) G4G26_14940 ENOG4105F1V Acetoin utilization protein G4G26_14945 ENOG4105W87 Cbs domain G4G26_14950 ENOG4105DGU Histone deacetylase G4G26_14955 ENOG4105ER2 Ompa motb domain protein G4G26_14960 ENOG4107R0U MotA TolQ exbB proton channel G4G26_14965 ENOG4105ETE Transcriptional regulator (LacI family G4G26_14970 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase G4G26_14990 ENOG4105DFU Cell wall formation (By similarity) G4G26_15000 ENOG4108VDD TRNA binding domain protein G4G26_15020 ENOG4108V0E nucleoside 2-deoxyribosyltransferase YtoQ G4G26_15035 ENOG4105C6K Malic enzyme G4G26_15040 ENOG4105C8F Beta-lactamase domain protein G4G26_15045 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) G4G26_15055 ENOG4108V15 phosphotransferase enzyme family G4G26_15060 ENOG4108IUM Glycogen debranching enzyme G4G26_15075 ENOG4107F58 2'-5' rna ligase G4G26_15080 ENOG4105C6T cysteine synthase G4G26_15085 ENOG4107QSE Dipeptidase G4G26_15090 ENOG4105C7N Xanthine uracil vitamin C permease G4G26_15105 ENOG4105YW5 deoR family transcriptional regulator G4G26_15120 ENOG4105CBX hi0933 family G4G26_15125 ENOG4105C94 Transporter G4G26_15135 ENOG4105MU9 integral membrane protein G4G26_15140 ENOG4105DDC Oxidoreductase domain protein G4G26_15150 ENOG4105F5H Glycosyl Hydrolase Family 88 G4G26_15160 ENOG41075H3 AraC family transcriptional regulator G4G26_15170 ENOG4105C50 Binding-protein-dependent transport systems, inner membrane component G4G26_15180 ENOG4106A3M Cytochrome p-450 G4G26_15185 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) G4G26_15195 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) G4G26_15200 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G4G26_15210 ENOG4105NTD Inherit from COG: Hydrolase G4G26_15240 ENOG41085GJ domain protein G4G26_15245 ENOG4105C8T Leucyl-tRNA synthetase G4G26_15255 ENOG4105BZU Histidine kinase G4G26_15260 ENOG410605W Major Facilitator G4G26_15265 ENOG4106UBQ G4G26_15275 ENOG4105C19 ABC transporter G4G26_15280 ENOG4105EWM Histidine kinase G4G26_15290 ENOG4107R34 abc transporter permease protein G4G26_15295 ENOG4105C19 ABC transporter G4G26_15310 ENOG4105DVE abc transporter atp-binding protein G4G26_15315 ENOG410811P TRANSCRIPTIONAl REGULATOR GntR family G4G26_15330 ENOG4105N5T Radical SAM Protein G4G26_15345 ENOG4105E8V Alpha Beta Hydrolase Fold protein G4G26_15350 ENOG4108Z0R Transferase G4G26_15355 ENOG4105C85 amino acid G4G26_15360 ENOG4105CAQ asparagine synthetase G4G26_15365 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP G4G26_15370 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase G4G26_15385 ENOG4105D2X ABC transporter substrate-binding protein G4G26_15395 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component G4G26_15410 ENOG4108RMU ferritin dps family protein G4G26_15425 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) G4G26_15430 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) G4G26_15435 ENOG4108V2W Carbonate dehydratase G4G26_15460 ENOG4105CC5 ABC transporter G4G26_15465 ENOG4105CC5 ABC transporter G4G26_15470 ENOG4105DIK (ABC) transporter G4G26_15475 ENOG4105DSE periplasmic solute binding protein G4G26_15480 ENOG4105DTQ mandelate racemase muconate lactonizing G4G26_15485 ENOG4105CEY Amp-dependent synthetase and ligase G4G26_15490 ENOG4108IPT Naphthoate synthase G4G26_15495 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) G4G26_15500 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) G4G26_15505 ENOG4105E4F Isochorismate synthase G4G26_15525 ENOG4108IAJ Nad-dependent epimerase dehydratase G4G26_15530 ENOG4107SBE Glycosyl transferase (Group 1 G4G26_15545 ENOG4107SBE Glycosyl transferase (Group 1 G4G26_15550 ENOG4108KS4 Spore coat protein G4G26_15565 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) G4G26_15575 ENOG4105CNB Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) G4G26_15705 ENOG4105N67 Proton-coupled thiamine transporter YuaJ G4G26_15710 ENOG4105VRR gCN5-related N-acetyltransferase G4G26_15715 ENOG4105DZ6 Band 7 protein G4G26_15725 ENOG4106DF1 G4G26_15730 ENOG4108VNY MOSC domain protein G4G26_15735 ENOG4108JB8 alcohol dehydrogenase G4G26_15745 ENOG4105TRT Transcriptional regulator G4G26_15760 ENOG4105CZN Potassium uptake protein G4G26_15765 ENOG4107I77 yiaA/B two helix domain G4G26_15770 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj G4G26_15790 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) G4G26_15800 ENOG4105EE0 oxidoreductase G4G26_15805 ENOG4105DKG l-rhamnose isomerase G4G26_15810 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) G4G26_15815 ENOG4105DET Rhamnulokinase G4G26_15820 ENOG4105E98 transcriptional regulator DeoR family G4G26_15830 ENOG4105C8Q Methyl-accepting chemotaxis G4G26_15835 ENOG4105C8Q Methyl-accepting chemotaxis G4G26_15840 ENOG4105C8Q Methyl-accepting chemotaxis G4G26_15845 ENOG4105C8Q Methyl-accepting chemotaxis G4G26_15860 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme G4G26_15875 ENOG4105C37 (CBS) domain G4G26_15890 ENOG4107PBV potassium channel G4G26_15895 ENOG4107PBV potassium channel G4G26_15910 ENOG4107QYV phosphohexose isomerase G4G26_15920 ENOG4107QW4 alcohol dehydrogenase G4G26_15925 ENOG4105WG9 Conserved Protein G4G26_15935 ENOG4105CHM Aminotransferase G4G26_15940 ENOG4108ZB6 transcriptional regulator AsnC family G4G26_15945 ENOG4108MUZ hydrolase G4G26_15955 ENOG4105C87 Aminotransferase class I and II G4G26_15960 ENOG4108HGU Histidine kinase G4G26_15965 ENOG4105Y38 Kinase-associated protein B G4G26_15985 ENOG4105BZ4 penicillin-binding protein G4G26_15990 ENOG4105KIR Thiol-disulfide oxidoreductase dcc G4G26_16005 ENOG4108MRH transcriptional regulatory protein G4G26_16010 ENOG4105DIH basic membrane G4G26_16015 ENOG4108JQ9 ABC transporter G4G26_16020 ENOG4105UIB (ABC) transporter G4G26_16040 ENOG4105D65 subunit l G4G26_16045 ENOG4105HC0 Na H antiporter G4G26_16050 ENOG4108ZE9 Monovalent cation H antiporter subunit C G4G26_16055 ENOG4108JPZ Monovalent cation H antiporter subunit D G4G26_16060 ENOG4105SC1 monovalent cation H antiporter subunit E G4G26_16070 ENOG4105KJM monovalent cation h antiporter subunit g G4G26_16075 ENOG4105KA0 thioesterase Superfamily protein G4G26_16085 ENOG4105BZU Histidine kinase G4G26_16115 ENOG4105D58 Diguanylate phosphodiesterase G4G26_16120 ENOG4105DAP Nicotinate phosphoribosyltransferase G4G26_16145 ENOG4105C02 permease G4G26_16165 ENOG410904N short-chain dehydrogenase reductase G4G26_16200 ENOG4108K8K Transcriptional regulator G4G26_16205 ENOG4105DCF alanine dehydrogenase G4G26_16215 ENOG4105WQT MbtH domain protein G4G26_16220 ENOG4105CEY Amp-dependent synthetase and ligase G4G26_16225 ENOG4105WQI isochorismatase G4G26_16230 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase G4G26_16235 ENOG4105E4F Isochorismate synthase G4G26_16240 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase G4G26_16245 ENOG4105NIV Esterase G4G26_16265 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) G4G26_16275 ENOG41069ER domain protein G4G26_16290 ENOG4105CEP NADH dehydrogenase G4G26_16295 ENOG4105CAY ferredoxin--nadp reductase G4G26_16315 ENOG41090PH Protease synthase and sporulation negative regulatory protein pai 1 G4G26_16320 ENOG4108YX9 iron--sulfur cluster insertion protein erpA G4G26_16335 ENOG4105ZKE UPF0349 protein G4G26_16350 ENOG41083MR nifu domain-containing protein G4G26_16355 ENOG4105DRY peptidase s9 prolyl oligopeptidase active site domain protein G4G26_16360 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) G4G26_16365 ENOG4108IYI Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity) G4G26_16370 ENOG4105D6E homoserine dehydrogenase G4G26_16380 ENOG4108W5N phosphatidylglycerophosphatase a G4G26_16385 ENOG4105D4U had-superfamily hydrolase, subfamily iia G4G26_16395 ENOG4105MMD transcriptional regulator G4G26_16400 ENOG4106EGE Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) G4G26_16405 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) G4G26_16410 ENOG4105FAA peptidase M23 G4G26_16415 ENOG4108YTE sporulation protein YunB G4G26_16420 ENOG4105KZD Domain of unknown function (DUF1805) G4G26_16425 ENOG4107R8B 5'-nucleotidase G4G26_16435 ENOG4105I3N Conserved Protein G4G26_16445 ENOG4105CD3 dihydroorotase G4G26_16450 ENOG4105G9B Transcriptional regulator G4G26_16465 ENOG4105FFA Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity) G4G26_16470 ENOG4105VT2 5-hydroxyisourate hydrolase G4G26_16480 ENOG4107YV9 domain protein G4G26_16485 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding G4G26_16500 ENOG4105XRQ Xanthine dehydrogenase accessory factor G4G26_16505 ENOG4105C5R Aminotransferase G4G26_16520 ENOG4108K8S endonuclease I G4G26_16525 ENOG4108IJ9 (ABC) transporter G4G26_16530 ENOG4105FDP GntR family transcriptional regulator G4G26_16535 ENOG4108KPW sugar kinase G4G26_16540 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component G4G26_16545 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component G4G26_16550 ENOG4105XN3 extracellular solute-binding protein family 1 G4G26_16555 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine G4G26_16560 ENOG4105PKS Excinuclease abc c subunit domain protein G4G26_16565 ENOG4107VFR oxidoreductase G4G26_16580 ENOG4105DIW FeS assembly protein SUFB G4G26_16585 ENOG4108UNV SUF system FeS assembly protein, NifU family G4G26_16590 ENOG4105C9B Cysteine desulfurase G4G26_16595 ENOG4105JRK feS assembly protein SufD G4G26_16600 ENOG4105C3K feS assembly ATPase SufC G4G26_16615 ENOG4105D01 (LipO)protein G4G26_16620 ENOG4108UMI ABC transporter, permease G4G26_16625 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) G4G26_16650 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) G4G26_16655 ENOG41080E8 Transcriptional regulator, Spx MgsR family G4G26_16660 ENOG4105C1G acyl-Coa dehydrogenase G4G26_16665 ENOG4105CHU acetyl-coa acetyltransferase G4G26_16695 ENOG41067TZ transcriptional regulator, MarR family G4G26_16700 ENOG4105C0R drug resistance transporter emrb qaca subfamily G4G26_16705 ENOG4105MDS 4-oxalocrotonate tautomerase G4G26_16715 ENOG4105EGI Transcriptional regulator G4G26_16725 ENOG4105E0A ABC, transporter G4G26_16740 ENOG4105E1F short-chain dehydrogenase reductase G4G26_16745 ENOG4105HUF DNA protection during starvation protein G4G26_16750 ENOG4105C0H protease G4G26_16760 ENOG4105F3H Histidine kinase G4G26_16770 ENOG41067SE Tetr family transcriptional regulator G4G26_16775 ENOG4105C9Q fumarate hydratase class II G4G26_16800 ENOG4105WH1 Two component transcriptional regulator luxr family G4G26_16805 ENOG4105ENE Histidine kinase G4G26_16820 ENOG41087YS Phage shock protein A G4G26_16835 ENOG4108WBT adenosyltransferase G4G26_16840 ENOG4105E0A ABC, transporter G4G26_16845 ENOG4105EHG Permease protein G4G26_16850 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) G4G26_16855 ENOG4105EWI Short-chain dehydrogenase reductase Sdr G4G26_16860 ENOG4105CYF SMP-30 gluconolaconase LRE domain protein G4G26_16870 ENOG4105DPZ Two component transcriptional regulator (Winged helix family G4G26_16880 ENOG4106DF4 Sigma-70, region 4 G4G26_16890 ENOG4105F0F Oxalate decarboxylase G4G26_16900 ENOG4107RBB ABC transporter, permease G4G26_16905 ENOG4105C19 ABC transporter G4G26_16910 ENOG4108WMK Efflux transporter RND family MFP subunit G4G26_16915 ENOG4105E0A ABC, transporter G4G26_16920 ENOG4105EHG Permease protein G4G26_16925 ENOG4105DQ5 transport system permease protein G4G26_16935 ENOG4105D5Q Arginine ornithine antiporter G4G26_16945 ENOG4107K5X Membrane-bound metal-dependent hydrolase G4G26_16950 ENOG4107QZ2 Sulfatase G4G26_16955 ENOG4105HD0 Transcriptional regulator of molybdate metabolism, LysR family G4G26_16960 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein G4G26_16965 ENOG4105E0C molybdate abc transporter G4G26_16980 ENOG4105EEQ Na H antiporter G4G26_16985 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) G4G26_16990 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G4G26_16995 ENOG4105EEM helicase G4G26_17000 ENOG4105EN6 Membrane G4G26_17010 ENOG4107ZQN disulfide bond G4G26_17015 ENOG4105C59 p-type ATPase G4G26_17020 ENOG4105C59 p-type ATPase G4G26_17025 ENOG410681U heavy metal transport detoxification protein G4G26_17030 ENOG4105VPX protein, conserved in bacteria G4G26_17035 ENOG4105D9R oxidoreductase G4G26_17040 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) G4G26_17045 ENOG4105ME7 Membrane G4G26_17050 ENOG4105RXJ G4G26_17055 ENOG4105KPY Small multidrug resistance protein G4G26_17060 ENOG4105KBX Transcriptional regulator, TetR family G4G26_17065 ENOG4105EWI Short-chain dehydrogenase reductase Sdr G4G26_17075 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) G4G26_17080 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) G4G26_17090 ENOG4105XZU Preprotein translocase, subunit SecG G4G26_17115 ENOG4105KVH Transcriptional regulator G4G26_17120 ENOG4105C8Q Methyl-accepting chemotaxis G4G26_17125 ENOG4105R40 Glycine betaine carnitine choline G4G26_17130 ENOG4108HQR Glycine betaine G4G26_17135 ENOG4105E90 ABC transporter G4G26_17140 ENOG4108IJ8 ABC transporter G4G26_17145 ENOG4107HG4 Transcriptional regulator G4G26_17150 ENOG4105R40 Glycine betaine carnitine choline G4G26_17155 ENOG4108HQR Glycine betaine G4G26_17160 ENOG4105E90 ABC transporter G4G26_17165 ENOG4108IJ8 ABC transporter G4G26_17170 ENOG4107HG4 Transcriptional regulator G4G26_17180 ENOG4108QCI YvbH-like oligomerisation region G4G26_17190 ENOG4105T65 Membrane-associated protein G4G26_17195 ENOG4108W0I acetyltransferase G4G26_17210 ENOG4105FJR Lmbe family G4G26_17230 ENOG4108IAJ Nad-dependent epimerase dehydratase G4G26_17235 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G4G26_17240 ENOG4107QQG Dehydrogenase G4G26_17245 ENOG4105IIU Aminopeptidase G4G26_17250 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) G4G26_17255 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) G4G26_17260 ENOG4105CP7 Triose-phosphate isomerase G4G26_17265 ENOG4105BZA Phosphoglycerate kinase G4G26_17270 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G4G26_17285 ENOG4105CMD Transcriptional regulator, GntR family G4G26_17290 ENOG4105DEN Luciferase family G4G26_17295 ENOG4105GZI Transcriptional regulator G4G26_17300 ENOG4107RT3 EamA-like transporter family G4G26_17310 ENOG4105VRS hydrolase family 18 G4G26_17315 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) G4G26_17320 ENOG4107QR9 Iron-sulfur cluster binding protein G4G26_17325 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) G4G26_17335 ENOG4105BZU Histidine kinase G4G26_17340 ENOG4105KCT ABC transporter G4G26_17345 ENOG4108M15 ABC transporter G4G26_17350 ENOG4107R6F Alpha Beta Hydrolase Fold protein G4G26_17355 ENOG4108MJI response regulator G4G26_17370 ENOG4105EG2 ABC transporter, permease G4G26_17380 ENOG4107FKK extracellular solute-binding protein family 1 G4G26_17390 ENOG4105JXH GntR family transcriptional regulator G4G26_17395 ENOG4105DAA L-lactate G4G26_17400 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G4G26_17410 ENOG4108ZPC Polysaccharide pyruvyl transferase G4G26_17415 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G4G26_17420 ENOG4105MME Sugar o-acyltransferase, sialic acid o-acetyltransferase neud family G4G26_17425 ENOG4105D3Q Sugar transferase G4G26_17435 ENOG4105K64 Glycosyl transferase, family 2 G4G26_17445 ENOG4107QRS glycosyltransferase group 2 family protein G4G26_17450 ENOG41068W6 Capsular polysaccharide biosynthesis protein G4G26_17455 ENOG4108KMV Glycosyl transferase (Group 1 G4G26_17460 ENOG4105K64 Glycosyl transferase, family 2 G4G26_17465 ENOG4108PQP glycosyl transferase group 1 G4G26_17475 ENOG4108QV3 biosynthesis protein G4G26_17480 ENOG4105HTX biosynthesis protein G4G26_17490 ENOG4105EBR Carboxylesterase G4G26_17500 ENOG4105PY6 Phenolic acid decarboxylase G4G26_17505 ENOG4105NI3 Protein of unknown function (DUF3237) G4G26_17515 ENOG4105FQP Beta-lactamase G4G26_17520 ENOG4105EDQ levansucrase EC 2.4.1.10 G4G26_17525 ENOG4108HKT sucrose-6-phosphate hydrolase G4G26_17530 ENOG4107QTZ amino acid G4G26_17555 ENOG4105DNP FAD linked oxidase domain protein G4G26_17560 ENOG4105IRW patatin-like phospholipase family protein G4G26_17570 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) G4G26_17575 ENOG4107URF beta-phospho-glucomutase G4G26_17580 ENOG4105CG3 alpha amylase, catalytic region G4G26_17595 ENOG4105EG2 ABC transporter, permease G4G26_17600 ENOG4105D56 permease protein G4G26_17605 ENOG4107FKK extracellular solute-binding protein family 1 G4G26_17610 ENOG4108IUK alpha amylase, catalytic G4G26_17615 ENOG4105FKQ transcriptional regulator G4G26_17620 ENOG4108URH decarboxylase G4G26_17625 ENOG4105TPC MazG nucleotide pyrophosphohydrolase domain G4G26_17630 ENOG4105CHH sulfate transporter G4G26_17635 ENOG4108V2W Carbonate dehydratase G4G26_17640 ENOG4105C5I Dehydrogenase G4G26_17650 ENOG4105C19 ABC transporter G4G26_17655 ENOG4105EWM Histidine kinase G4G26_17665 ENOG4107A6P G4G26_17670 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase G4G26_17675 ENOG4105KRI phosphocarrier protein (HPr G4G26_17680 ENOG4105CIE May be required for sporulation (By similarity) G4G26_17685 ENOG4105CHW UPF0052 protein G4G26_17690 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) G4G26_17695 ENOG4108Z4K mutator MutT protein G4G26_17700 ENOG4105C3M thioredoxin reductase G4G26_17715 ENOG4105BZ1 (ABC) transporter G4G26_17725 ENOG4106FGC G4G26_17735 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase G4G26_17740 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) G4G26_17745 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase G4G26_17750 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) G4G26_17755 ENOG4105ECC imidazole-glycerol-phosphate dehydratase G4G26_17760 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) G4G26_17765 ENOG4107RN8 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) G4G26_17770 ENOG4105C49 Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity) G4G26_17780 ENOG4108E16 pectate lyase G4G26_17785 ENOG4108S4C acetyltransferase G4G26_17790 ENOG4107XGZ Hydrolase G4G26_17795 ENOG4105HKU nucleoside recognition domain-containing protein G4G26_17800 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) G4G26_17805 ENOG4105D1C Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity) G4G26_17810 ENOG4105CE4 GlcNAc 6-P deacetylase G4G26_17815 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) G4G26_17825 ENOG41088CQ domain protein G4G26_17830 ENOG41086DT Membrane protein of unknown function G4G26_17835 ENOG41067S9 phage shock protein C, PspC G4G26_17840 ENOG4108PY7 G4G26_17860 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) G4G26_17865 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) G4G26_17880 ENOG4105MKU Transcriptional regulator G4G26_17900 ENOG4105CN1 protease G4G26_17905 ENOG4105CRP Part of the ABC transporter FtsEX involved in G4G26_17910 ENOG4105CAK Cell division ATP-binding protein ftsE G4G26_17935 ENOG4105MS2 ribosomal subunit Interface protein G4G26_17950 ENOG4105MQ3 flagellar protein FliS G4G26_17955 ENOG4107RT6 flagellar hook-associated G4G26_17960 ENOG41083S7 flagellar protein FlaG G4G26_17965 ENOG4105I03 Flagellin G4G26_17970 ENOG41085Y9 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) G4G26_17975 ENOG4105W5T Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity) G4G26_17980 ENOG4105MKD G4G26_17985 ENOG4105DTJ flagellar hook-associated protein G4G26_17990 ENOG4105E1Q flagellar hook-associated protein G4G26_18005 ENOG4105RU3 G4G26_18010 ENOG41081UC Inherit from COG: Competence protein G4G26_18030 ENOG4105WH1 Two component transcriptional regulator luxr family G4G26_18035 ENOG4105BZU Histidine kinase G4G26_18040 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein G4G26_18045 ENOG4108KGH TRANSCRIPTIONal G4G26_18050 ENOG4105ESV Glycosyl transferase, family 4 G4G26_18055 ENOG4107EF8 Glycosyl transferase (Group 1 G4G26_18070 ENOG4105QZI O-Antigen Polymerase G4G26_18075 ENOG4105C6Y Udp-glucose 6-dehydrogenase G4G26_18080 ENOG4107RA4 Glycosyl transferase (Group 1 G4G26_18085 ENOG4105PSV Polysaccharide Biosynthesis Protein G4G26_18090 ENOG4105D3Q Sugar transferase G4G26_18095 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase G4G26_18100 ENOG4105JFG SpoIID LytB domain protein G4G26_18115 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase G4G26_18120 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G4G26_18130 ENOG4107VDP teichoic acid biosynthesis G4G26_18135 ENOG41088M2 Glycosyl transferase family 2 G4G26_18150 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G4G26_18155 ENOG4105EY8 ABC transporter G4G26_18165 ENOG4107SJB teichoic acid biosynthesis G4G26_18170 ENOG4108NMT An N-acetylglucosaminyl transferase that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon (By similarity) G4G26_18175 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase G4G26_18185 ENOG4107RZX Teichoic acid biosynthesis protein G4G26_18200 ENOG4105DG6 mannose-6-phosphate isomerase G4G26_18215 ENOG4108NHD germination protein G4G26_18220 ENOG4105C54 Major Facilitator superfamily G4G26_18225 ENOG4108KGH TRANSCRIPTIONal G4G26_18230 ENOG4105J7I hydrolase G4G26_18235 ENOG4105K4H Nlp p60 protein G4G26_18245 ENOG4105PNM synthesis protein G4G26_18255 ENOG4105N98 Capsule biosynthesis protein capB G4G26_18260 ENOG4105ETE Transcriptional regulator (LacI family G4G26_18265 ENOG4108RVA ribokinase G4G26_18270 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) G4G26_18275 ENOG4105C2J ABC transporter G4G26_18280 ENOG4105CNN ABC, transporter G4G26_18285 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator G4G26_18300 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein G4G26_18305 ENOG4107FQX Alpha-acetolactate decarboxylase G4G26_18315 ENOG4107RSM transcriptional regulator G4G26_18330 ENOG4106UIA G4G26_18345 ENOG4107XC4 flavin reductase domain protein, FMN-binding G4G26_18355 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G4G26_18365 ENOG4105CAH Chromate G4G26_18370 ENOG4105FGV Chromate G4G26_18380 ENOG4108WS4 fmn reductase G4G26_18385 ENOG4107V2S Transcriptional regulator G4G26_18390 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) G4G26_18420 ENOG4108XI2 Domain of unknown function (DUF1963) G4G26_18425 ENOG4105C6Y Udp-glucose 6-dehydrogenase G4G26_18430 ENOG4108RB3 Capsular polysaccharide biosynthesis protein G4G26_18435 ENOG4107YJ4 chain length determinant protein G4G26_18440 ENOG4105HTX biosynthesis protein G4G26_18450 ENOG4105KBK Zinc finger, swim domain protein G4G26_18455 ENOG4105C0D helicase G4G26_18460 ENOG410667J hydrolase G4G26_18465 ENOG4105E98 transcriptional regulator DeoR family G4G26_18470 ENOG4105Z8H single-stranded DNA-binding protein G4G26_18495 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) G4G26_18500 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) G4G26_18510 ENOG4105CGA flagellar basal-body rod protein FlgG G4G26_18520 ENOG4105DFF Rod shape-determining protein mreb G4G26_18525 ENOG4105MT0 Sporulation transcriptional regulator spoiiid G4G26_18535 ENOG4107MII Sugar-specific transcriptional regulator TrmB G4G26_18540 ENOG4105CZM Major Facilitator G4G26_18545 ENOG4108M26 parallel beta-helix repeat protein G4G26_18550 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease G4G26_18555 ENOG41080V3 Major Facilitator superfamily G4G26_18560 ENOG4105D3W isochorismatase G4G26_18565 ENOG4107P26 G4G26_18570 ENOG4105BZU Histidine kinase G4G26_18580 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase G4G26_18590 ENOG4105FRN stage II sporulation protein G4G26_18595 ENOG4107TCE N-acetyltransferase G4G26_18615 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) G4G26_18620 ENOG4107TXC Transcriptional regulator G4G26_18625 ENOG4106BRK G4G26_18635 ENOG4108Z40 Transcriptional regulator G4G26_18640 ENOG4105CQM Urea amidohydrolase subunit alpha G4G26_18645 ENOG4105KI2 Urea amidohydrolase subunit beta G4G26_18650 ENOG4108YZ9 Urea amidohydrolase subunit gamma G4G26_18685 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) G4G26_18695 ENOG4108TF4 von Willebrand factor, type A G4G26_18710 ENOG4105JFG SpoIID LytB domain protein G4G26_18715 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) G4G26_18725 ENOG4106778 Protein of unknown function (DUF1146) G4G26_18735 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) G4G26_18740 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) G4G26_18745 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) G4G26_18750 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) G4G26_18770 ENOG4107RB6 it plays a direct role in the translocation of protons across the membrane (By similarity) G4G26_18780 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) G4G26_18785 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) G4G26_18790 ENOG4108UIC UPF0340 protein G4G26_18795 ENOG4108YZG isomerase G4G26_18800 ENOG4107WAU Protein tyrosine phosphatase G4G26_18805 ENOG410815N Probably functions as a manganese efflux pump (By similarity) G4G26_18810 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) G4G26_18820 ENOG4108ZXQ stage ii sporulation protein r G4G26_18835 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G4G26_18840 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) G4G26_18845 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase G4G26_18855 ENOG4107TT2 Auxin Efflux Carrier G4G26_18860 ENOG4105C6K Malic enzyme G4G26_18865 ENOG4107104 thymidine kinase G4G26_18875 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) G4G26_18885 ENOG4105CBT Fructose-1,6-bisphosphatase G4G26_18890 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) G4G26_18895 ENOG4107XMI Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway G4G26_18900 ENOG4105D2N Aldolase G4G26_18905 ENOG410812K response regulator receiver protein G4G26_18915 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) G4G26_18925 ENOG4105C1G acyl-Coa dehydrogenase G4G26_18930 ENOG4105DF6 Fe-S oxidoreductase G4G26_18940 ENOG4105E5J UV damage endonuclease G4G26_18950 ENOG4105NAE bifunctional deaminase-reductase domain protein G4G26_18955 ENOG4105BZ1 (ABC) transporter G4G26_18960 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) G4G26_18975 ENOG4105R3A Nitrate reductase G4G26_18980 ENOG4108IUE nitrate reductase beta subunit G4G26_19000 ENOG4107V6Q Cyclic nucleotide-binding domain G4G26_19010 ENOG4105C75 arginyL-tRNA synthetase G4G26_19015 ENOG410684U Domain of unknown function (DUF1934) G4G26_19030 ENOG4105EZY Pyrroloquinoline quinone biosynthesis protein E G4G26_19080 ENOG4107JM4 Tetratricopeptide repeat G4G26_19110 ENOG4108RDQ ABC transporter G4G26_19120 ENOG4105CYW agmatinase G4G26_19125 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) G4G26_19130 ENOG4105BZ4 penicillin-binding protein G4G26_19135 ENOG4108XFG YwhD family G4G26_19140 ENOG4108Z4T Peptidase M50 G4G26_19145 ENOG41069HH 4-oxalocrotonate tautomerase G4G26_19150 ENOG41067TZ transcriptional regulator, MarR family G4G26_19155 ENOG4105C22 threonyL-tRNA synthetase G4G26_19160 ENOG4105C57 major facilitator superfamily G4G26_19165 ENOG41062ES Transcriptional regulator G4G26_19175 ENOG4105DCI Phosphohydrolase G4G26_19185 ENOG4108VCI transcription factor, rsfa family G4G26_19190 ENOG4108RNG Permease of the drug metabolite transporter G4G26_19195 ENOG4105JGI Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes (By similarity) G4G26_19200 ENOG4105DUM transcriptional regulator, lysR family G4G26_19205 ENOG4108IJ2 phosphate acetyltransferase G4G26_19220 ENOG4105CHM Aminotransferase G4G26_19230 ENOG4108V3M Inherit from COG: acetyl-CoA carboxylase biotin carboxylase G4G26_19235 ENOG4105CHR reductase G4G26_19240 ENOG4106CHD Bacilysin biosynthesis protein bacB G4G26_19245 ENOG41061WN bacilysin biosynthesis protein G4G26_19250 ENOG4105FCW Major Facilitator superfamily G4G26_19265 ENOG4105C26 Dehydrogenase G4G26_19270 ENOG4105D82 Glutamate dehydrogenase G4G26_19280 ENOG4107ZIM Dtdp-4-dehydrorhamnose 3,5-epimerase G4G26_19285 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase G4G26_19290 ENOG4105C1B dTDP-glucose 4-6-dehydratase G4G26_19295 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) G4G26_19300 ENOG4107P9E Inherit from COG: pseudaminic acid biosynthesis-associated protein PseG G4G26_19305 ENOG4107TY6 Acylneuraminate cytidylyltransferase G4G26_19315 ENOG41067MN Spore coat polysaccharide biosynthesis protein spsD G4G26_19320 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G4G26_19355 ENOG4105C26 Dehydrogenase G4G26_19360 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) G4G26_19365 ENOG4108RJ9 Glycosyl transferase, family 2 G4G26_19370 ENOG4105DWF phosphomethylpyrimidine kinase G4G26_19385 ENOG4105C5Y PTS System G4G26_19390 ENOG4108QTI )-transporter G4G26_19405 ENOG4105EY9 peptidase S8 and S53, subtilisin, kexin, sedolisin G4G26_19410 ENOG4105DEN Luciferase family G4G26_19415 ENOG4108DBC nitroreductase G4G26_19430 ENOG41060D1 Quinol oxidase G4G26_19435 ENOG4105CCU oxidase (Subunit III) G4G26_19440 ENOG4105BZ9 Cytochrome C oxidase, subunit I G4G26_19445 ENOG4105E2S oxidase) subunit II G4G26_19450 ENOG4107BMA Transglycosylase associated protein G4G26_19460 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) G4G26_19465 ENOG4105WH5 Teichoic acid glycosylation protein G4G26_19490 ENOG4107ZXU DSBA oxidoreductase G4G26_19495 ENOG4105DBE peroxidase G4G26_19500 ENOG410650H (LipO)protein G4G26_19505 ENOG4107SJW iron permease, FTR1 G4G26_19510 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) G4G26_19520 ENOG4105CMU LysR family (Transcriptional regulator G4G26_19525 ENOG4105VAW lrga family G4G26_19530 ENOG41067MG lrgb family G4G26_19535 ENOG4105D8G Major Facilitator superfamily G4G26_19545 ENOG4105DR4 Methyltransferase G4G26_19560 ENOG4108YV3 Protein of unknown function (DUF2711) G4G26_19565 ENOG4105CK1 PTS System G4G26_19570 ENOG4105J8Z peptidase S8 and S53, subtilisin, kexin, sedolisin G4G26_19585 ENOG4105X1N Glycosyl transferase family 8 G4G26_19595 ENOG4105GVJ transcriptional regulator G4G26_19600 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) G4G26_19605 ENOG4105IIU Aminopeptidase G4G26_19630 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase G4G26_19645 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) G4G26_19650 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein G4G26_19660 ENOG4108M4D D-alanyl-lipoteichoic acid biosynthesis protein DltD G4G26_19665 ENOG4108VHC Short-chain dehydrogenase reductase Sdr G4G26_19670 ENOG4105CM2 brancheD-chain amino acid aminotransferase G4G26_19675 ENOG4105F8D glycoside hydrolase family 4 G4G26_19680 ENOG4105VCP PTS System G4G26_19685 ENOG4105CK1 PTS System G4G26_19690 ENOG4105VZJ PTS System G4G26_19695 ENOG4105EMD TRANSCRIPTIONal G4G26_19705 ENOG4108VX5 3-methyladenine DNA glycosylase G4G26_19710 ENOG4105CH6 catalase G4G26_19725 ENOG4105DA5 (ABC) transporter G4G26_19730 ENOG41069JR G4G26_19750 ENOG4105ETS cytosine purines uracil thiamine allantoin G4G26_19755 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) G4G26_19760 ENOG4108JJ8 (ABC) transporter G4G26_19765 ENOG4108JJ9 ABC, transporter G4G26_19770 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G4G26_19775 ENOG4105C4M (Ubiquinol oxidase) subunit I G4G26_19780 ENOG4105D2K citrate carrier protein G4G26_19795 ENOG4107BJW polysaccharide deacetylase G4G26_19815 ENOG410749K Uncharacterized protein conserved in bacteria (DUF2179) G4G26_19825 ENOG4105CMR udp-glucose 4-epimerase G4G26_19835 ENOG4105BZU Histidine kinase G4G26_19840 ENOG4105WH1 Two component transcriptional regulator luxr family G4G26_19845 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) G4G26_19870 ENOG4105DTD Dehydrogenase G4G26_19875 ENOG4108IIH CoA-transferase subunit B G4G26_19880 ENOG4105D6N CoA-transferase, subunit a G4G26_19885 ENOG4105CY2 Citrate transporter G4G26_19890 ENOG4105DHI Methyltransferase G4G26_19910 ENOG4105CH6 catalase G4G26_19915 ENOG4105D4T Citrate transporter G4G26_19920 ENOG4108RZ2 Glycoside hydrolase family 16 G4G26_19925 ENOG4105CID antiterminator G4G26_19935 ENOG4105DEU major facilitator superfamily G4G26_19940 ENOG4105C1J atp-dependent rna helicase G4G26_19945 ENOG4107TDE lipolytic protein G-D-S-L family G4G26_20005 ENOG4107YZX Universal stress protein G4G26_20010 ENOG4105CS2 ec 3.2.1.21 G4G26_20015 ENOG4105C5Y PTS System G4G26_20030 ENOG4107EV6 Inherit from COG: YD repeat protein G4G26_20045 ENOG4106Z5D Glycoside Hydrolase Family 43 G4G26_20060 ENOG4105C84 Histidine ammonia-lyase G4G26_20065 ENOG4105CGP Urocanate hydratase G4G26_20070 ENOG4105CI2 imidazolone-5-propionate hydrolase G4G26_20075 ENOG4107W25 arginase agmatinase formiminoglutamase G4G26_20085 ENOG4105CMW The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity) G4G26_20090 ENOG4105D9N nucleoside G4G26_20100 ENOG4107RHR regulatoR G4G26_20105 ENOG4108TM9 integral membrane protein G4G26_20110 ENOG4105ENY Ethanolamine utilization protein eutH G4G26_20115 ENOG4108PGP mmge prpd family protein G4G26_20130 ENOG4108HW4 amino acid AbC transporter G4G26_20135 ENOG4105EAB amino acid AbC transporter G4G26_20150 ENOG4107QHE Choloylglycine hydrolase G4G26_20155 ENOG410667J hydrolase G4G26_20185 ENOG4108V5C ABC transporter G4G26_20215 ENOG4105D2N Aldolase G4G26_20220 ENOG4107TRN Xylose isomerase domain protein TIM barrel G4G26_20225 ENOG4105F0H myo-inositol catabolism protein G4G26_20230 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) G4G26_20240 ENOG4105CJK Catalyzes the dehydration of inosose (2-keto-myo- inositol, 2KMI or 2,4,6 3,5-pentahydroxycyclohexanone) to 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (D-2,3-diketo-4-deoxy-epi- inositol) (By similarity) G4G26_20245 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) G4G26_20250 ENOG4105D7K pfkb domain protein G4G26_20260 ENOG4105C26 Dehydrogenase G4G26_20270 ENOG4105CPC Aldo Keto reductase G4G26_20285 ENOG4107QNK )-transporter G4G26_20290 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) G4G26_20300 ENOG41061TZ Short-chain dehydrogenase reductase Sdr G4G26_20305 ENOG4105ST3 Transcriptional regulator G4G26_20310 ENOG4105C26 Dehydrogenase G4G26_20315 ENOG41085PJ rdd domain containing protein G4G26_20320 ENOG4108ITS PQQ enzyme repeat G4G26_20330 ENOG41085PJ rdd domain containing protein G4G26_20345 ENOG4105J7D transcriptional regulator G4G26_20350 ENOG4107JEE Short-chain dehydrogenase reductase Sdr G4G26_20355 ENOG41061AU MarR family Transcriptional regulator G4G26_20365 ENOG41067MG lrgb family G4G26_20375 ENOG4105BZW Glycerate kinase G4G26_20380 ENOG4105G3Z GntR family transcriptional regulator G4G26_20385 ENOG4105CMG Carbohydrate kinase G4G26_20390 ENOG4105C6Z Gluconate G4G26_20395 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) G4G26_20400 ENOG4105D3R alkyl hydroperoxide reductase G4G26_20405 ENOG4108JU3 Alkyl hydroperoxide reductase G4G26_20420 ENOG4105DMC D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3 G4G26_20435 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) G4G26_20450 ENOG4105E2A Dehydrogenase G4G26_20470 ENOG4105NUN Orthopoxvirus protein of unknown function (DUF830) G4G26_20475 ENOG4105WQG acetyltransferase G4G26_20480 ENOG410780I phosphoprotein phosphatase activity G4G26_20490 ENOG41066UZ arginase EC 3.5.3.1 G4G26_20495 ENOG4108IQI permease G4G26_20500 ENOG4105C8Y Acetylornithine aminotransferase G4G26_20525 ENOG41082BM Transcriptional regulator, arsr family G4G26_20530 ENOG4108JUB Transcriptional regulator G4G26_20545 ENOG4105C0H protease G4G26_20550 ENOG4105Q2H domain protein G4G26_20565 ENOG4105BZU Histidine kinase G4G26_20570 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G4G26_20595 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis G4G26_20600 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase G4G26_20605 ENOG4105CDU Replicative dna helicase G4G26_20625 ENOG4105DJ2 Major Facilitator Superfamily G4G26_20630 ENOG4105EDW glycosyl transferase, family 39 G4G26_20635 ENOG4105K9Q Binds to the 23S rRNA (By similarity) G4G26_20640 ENOG4105BZR domain protein G4G26_20645 ENOG4108XMW Membrane G4G26_20660 ENOG4105KVH Transcriptional regulator G4G26_20665 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase G4G26_20680 ENOG41090E6 transcriptional regulator MERR family G4G26_20690 ENOG4108VSZ Inherit from COG: ketosteroid isomerase-like protein G4G26_20695 ENOG4105DDN Pentapeptide repeat-containing protein G4G26_20700 ENOG4105D94 Major Facilitator Superfamily G4G26_20705 ENOG4107RSM transcriptional regulator G4G26_20710 ENOG41082BV acetyltransferase G4G26_20715 ENOG41081I9 integral membrane protein G4G26_20730 ENOG4108U05 Transcriptional regulator G4G26_20735 ENOG41082BV acetyltransferase G4G26_20745 ENOG4108U7W acetyltransferase G4G26_20750 ENOG4105UNS Pfam:DUF419 G4G26_20755 ENOG4105NAE bifunctional deaminase-reductase domain protein G4G26_20765 ENOG4108J8C transporter major facilitator family protein G4G26_20785 ENOG4108IPJ Membrane G4G26_20790 ENOG4105C7Z Conserved Protein G4G26_20795 ENOG4107FCW Abortive infection protein G4G26_20805 ENOG4108UW5 maltose o-acetyltransferase G4G26_20810 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase G4G26_20820 ENOG4105CGK Exodeoxyribonuclease III G4G26_20825 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) G4G26_20830 ENOG4108UUM single-stranded DNA-binding protein G4G26_20835 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) G4G26_20840 ENOG4105C3G gtp-binding protein G4G26_20845 ENOG4108J2R molybdopterin oxidoreductase G4G26_20850 ENOG4105VDK protein, conserved in bacteria G4G26_20860 ENOG4108ZDA Sporulation protein YyaC G4G26_20865 ENOG4105FA0 parb-like partition protein G4G26_20870 ENOG4107QJE Chromosome Partitioning Protein G4G26_20885 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) G4G26_20890 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) G4G26_20895 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) G4G26_20910 ENOG4105M7T RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)